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Network neighborhood for query Sequence : SHAN2_MOUSE

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SHAN2_MOUSE
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SHAN2_HUMAN
θ value	0 (rank : 1)	NC score	0.910335 (rank : 2)
Query Neighborhood Hits	446	Target Neighborhood Hits	346	Shared Neighborhood Hits	223
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

SHAN2_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	446	Target Neighborhood Hits	446	Shared Neighborhood Hits	446
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SHAN1_HUMAN
θ value	1.17455e-116 (rank : 3)	NC score	0.505642 (rank : 3)
Query Neighborhood Hits	446	Target Neighborhood Hits	1041	Shared Neighborhood Hits	305
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

DGKD_HUMAN
θ value	2.28291e-11 (rank : 4)	NC score	0.242552 (rank : 56)
Query Neighborhood Hits	446	Target Neighborhood Hits	231	Shared Neighborhood Hits	59
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

DGKH_HUMAN
θ value	1.47974e-10 (rank : 5)	NC score	0.232467 (rank : 81)
Query Neighborhood Hits	446	Target Neighborhood Hits	255	Shared Neighborhood Hits	64
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

PDZD1_HUMAN
θ value	3.41135e-07 (rank : 6)	NC score	0.408980 (rank : 6)
Query Neighborhood Hits	446	Target Neighborhood Hits	190	Shared Neighborhood Hits	119
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

NHERF_HUMAN
θ value	9.92553e-07 (rank : 7)	NC score	0.415913 (rank : 4)
Query Neighborhood Hits	446	Target Neighborhood Hits	190	Shared Neighborhood Hits	119
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHERF_MOUSE
θ value	1.29631e-06 (rank : 8)	NC score	0.415336 (rank : 5)
Query Neighborhood Hits	446	Target Neighborhood Hits	195	Shared Neighborhood Hits	119
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

ARHGC_MOUSE
θ value	2.88788e-06 (rank : 9)	NC score	0.302406 (rank : 25)
Query Neighborhood Hits	446	Target Neighborhood Hits	344	Shared Neighborhood Hits	134
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

SAM14_HUMAN
θ value	3.77169e-06 (rank : 10)	NC score	0.289840 (rank : 36)
Query Neighborhood Hits	446	Target Neighborhood Hits	81	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IZD0, Q8N2X0	Gene names	SAMD14
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 14.

ARHGC_HUMAN
θ value	6.43352e-06 (rank : 11)	NC score	0.302814 (rank : 24)
Query Neighborhood Hits	446	Target Neighborhood Hits	351	Shared Neighborhood Hits	134
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

SAMD9_HUMAN
θ value	6.43352e-06 (rank : 12)	NC score	0.210563 (rank : 111)
Query Neighborhood Hits	446	Target Neighborhood Hits	79	Shared Neighborhood Hits	15
SwissProt Accessions	Q5K651, Q6P080, Q75N21, Q8IVG6, Q9NXS8	Gene names	SAMD9, KIAA2004, OEF1
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 9.

ARHG7_HUMAN
θ value	1.87187e-05 (rank : 13)	NC score	0.268206 (rank : 44)
Query Neighborhood Hits	446	Target Neighborhood Hits	347	Shared Neighborhood Hits	122
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

PDZD1_MOUSE
θ value	1.87187e-05 (rank : 14)	NC score	0.398591 (rank : 7)
Query Neighborhood Hits	446	Target Neighborhood Hits	191	Shared Neighborhood Hits	116
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

ARHG7_MOUSE
θ value	3.19293e-05 (rank : 15)	NC score	0.265041 (rank : 49)
Query Neighborhood Hits	446	Target Neighborhood Hits	396	Shared Neighborhood Hits	120
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHGB_HUMAN
θ value	3.19293e-05 (rank : 16)	NC score	0.302165 (rank : 26)
Query Neighborhood Hits	446	Target Neighborhood Hits	375	Shared Neighborhood Hits	143
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHG6_MOUSE
θ value	4.1701e-05 (rank : 17)	NC score	0.267338 (rank : 45)
Query Neighborhood Hits	446	Target Neighborhood Hits	394	Shared Neighborhood Hits	115
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG6_HUMAN
θ value	5.44631e-05 (rank : 18)	NC score	0.268327 (rank : 43)
Query Neighborhood Hits	446	Target Neighborhood Hits	376	Shared Neighborhood Hits	113
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

SH3K1_HUMAN
θ value	5.44631e-05 (rank : 19)	NC score	0.288990 (rank : 37)
Query Neighborhood Hits	446	Target Neighborhood Hits	341	Shared Neighborhood Hits	128
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

GRASP_HUMAN
θ value	7.1131e-05 (rank : 20)	NC score	0.378479 (rank : 11)
Query Neighborhood Hits	446	Target Neighborhood Hits	147	Shared Neighborhood Hits	98
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

MAGI1_HUMAN
θ value	9.29e-05 (rank : 21)	NC score	0.314176 (rank : 19)
Query Neighborhood Hits	446	Target Neighborhood Hits	388	Shared Neighborhood Hits	134
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

GRASP_MOUSE
θ value	0.000158464 (rank : 22)	NC score	0.372971 (rank : 13)
Query Neighborhood Hits	446	Target Neighborhood Hits	131	Shared Neighborhood Hits	95
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

MAGI2_MOUSE
θ value	0.000158464 (rank : 23)	NC score	0.303447 (rank : 23)
Query Neighborhood Hits	446	Target Neighborhood Hits	370	Shared Neighborhood Hits	135
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

MAST3_HUMAN
θ value	0.000158464 (rank : 24)	NC score	0.095020 (rank : 329)
Query Neighborhood Hits	446	Target Neighborhood Hits	1128	Shared Neighborhood Hits	177
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

PDZD3_MOUSE
θ value	0.000158464 (rank : 25)	NC score	0.382597 (rank : 10)
Query Neighborhood Hits	446	Target Neighborhood Hits	171	Shared Neighborhood Hits	115
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

VAV_MOUSE
θ value	0.000158464 (rank : 26)	NC score	0.244952 (rank : 55)
Query Neighborhood Hits	446	Target Neighborhood Hits	430	Shared Neighborhood Hits	116
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

NHRF2_HUMAN
θ value	0.00020696 (rank : 27)	NC score	0.393998 (rank : 8)
Query Neighborhood Hits	446	Target Neighborhood Hits	197	Shared Neighborhood Hits	119
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

SAM14_MOUSE
θ value	0.00020696 (rank : 28)	NC score	0.254824 (rank : 52)
Query Neighborhood Hits	446	Target Neighborhood Hits	91	Shared Neighborhood Hits	38
SwissProt Accessions	Q8K070, Q5SWB7, Q8BHE2, Q8C8N5	Gene names	Samd14
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 14.

CNKR2_HUMAN
θ value	0.000270298 (rank : 29)	NC score	0.227306 (rank : 89)
Query Neighborhood Hits	446	Target Neighborhood Hits	197	Shared Neighborhood Hits	73
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	0.000270298 (rank : 30)	NC score	0.227423 (rank : 88)
Query Neighborhood Hits	446	Target Neighborhood Hits	197	Shared Neighborhood Hits	73
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

LAP4_MOUSE
θ value	0.000270298 (rank : 31)	NC score	0.191998 (rank : 137)
Query Neighborhood Hits	446	Target Neighborhood Hits	590	Shared Neighborhood Hits	145
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

MAGI2_HUMAN
θ value	0.000270298 (rank : 32)	NC score	0.306888 (rank : 21)
Query Neighborhood Hits	446	Target Neighborhood Hits	373	Shared Neighborhood Hits	136
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

PDZD3_HUMAN
θ value	0.000270298 (rank : 33)	NC score	0.375656 (rank : 12)
Query Neighborhood Hits	446	Target Neighborhood Hits	180	Shared Neighborhood Hits	119
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

PSCBP_HUMAN
θ value	0.000270298 (rank : 34)	NC score	0.353845 (rank : 15)
Query Neighborhood Hits	446	Target Neighborhood Hits	123	Shared Neighborhood Hits	94
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

RHPN1_MOUSE
θ value	0.000270298 (rank : 35)	NC score	0.252087 (rank : 53)
Query Neighborhood Hits	446	Target Neighborhood Hits	154	Shared Neighborhood Hits	98
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

STAC_MOUSE
θ value	0.000461057 (rank : 36)	NC score	0.238631 (rank : 63)
Query Neighborhood Hits	446	Target Neighborhood Hits	268	Shared Neighborhood Hits	115
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

MY18A_MOUSE
θ value	0.000602161 (rank : 37)	NC score	0.082665 (rank : 385)
Query Neighborhood Hits	446	Target Neighborhood Hits	1989	Shared Neighborhood Hits	154
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

NHRF2_MOUSE
θ value	0.000602161 (rank : 38)	NC score	0.384219 (rank : 9)
Query Neighborhood Hits	446	Target Neighborhood Hits	194	Shared Neighborhood Hits	118
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

SAMH1_MOUSE
θ value	0.000602161 (rank : 39)	NC score	0.137543 (rank : 210)
Query Neighborhood Hits	446	Target Neighborhood Hits	19	Shared Neighborhood Hits	9
SwissProt Accessions	Q60710, Q91VK8	Gene names	Samhd1, Mg11
Domain Architecture
Description	SAM domain and HD domain-containing protein 1 (Interferon-gamma- inducible protein Mg11).

VAV2_MOUSE
θ value	0.000602161 (rank : 40)	NC score	0.235891 (rank : 70)
Query Neighborhood Hits	446	Target Neighborhood Hits	456	Shared Neighborhood Hits	112
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV_HUMAN
θ value	0.000602161 (rank : 41)	NC score	0.241822 (rank : 57)
Query Neighborhood Hits	446	Target Neighborhood Hits	452	Shared Neighborhood Hits	115
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

EPHA5_HUMAN
θ value	0.000786445 (rank : 42)	NC score	0.091380 (rank : 339)
Query Neighborhood Hits	446	Target Neighborhood Hits	1009	Shared Neighborhood Hits	73
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

LAP4_HUMAN
θ value	0.000786445 (rank : 43)	NC score	0.197767 (rank : 125)
Query Neighborhood Hits	446	Target Neighborhood Hits	608	Shared Neighborhood Hits	147
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

MAST2_MOUSE
θ value	0.000786445 (rank : 44)	NC score	0.093085 (rank : 334)
Query Neighborhood Hits	446	Target Neighborhood Hits	1110	Shared Neighborhood Hits	167
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

VAV2_HUMAN
θ value	0.000786445 (rank : 45)	NC score	0.239210 (rank : 61)
Query Neighborhood Hits	446	Target Neighborhood Hits	453	Shared Neighborhood Hits	112
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

MAST2_HUMAN
θ value	0.00102713 (rank : 46)	NC score	0.094729 (rank : 330)
Query Neighborhood Hits	446	Target Neighborhood Hits	1189	Shared Neighborhood Hits	178
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MLTK_MOUSE
θ value	0.00102713 (rank : 47)	NC score	0.078271 (rank : 426)
Query Neighborhood Hits	446	Target Neighborhood Hits	874	Shared Neighborhood Hits	63
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

GOPC_HUMAN
θ value	0.00134147 (rank : 48)	NC score	0.290819 (rank : 35)
Query Neighborhood Hits	446	Target Neighborhood Hits	377	Shared Neighborhood Hits	116
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

GOPC_MOUSE
θ value	0.00134147 (rank : 49)	NC score	0.292957 (rank : 31)
Query Neighborhood Hits	446	Target Neighborhood Hits	323	Shared Neighborhood Hits	110
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

M3K11_HUMAN
θ value	0.00134147 (rank : 50)	NC score	0.110628 (rank : 265)
Query Neighborhood Hits	446	Target Neighborhood Hits	1136	Shared Neighborhood Hits	170
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

MAGI1_MOUSE
θ value	0.00134147 (rank : 51)	NC score	0.306251 (rank : 22)
Query Neighborhood Hits	446	Target Neighborhood Hits	403	Shared Neighborhood Hits	132
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MAST1_HUMAN
θ value	0.00134147 (rank : 52)	NC score	0.094237 (rank : 332)
Query Neighborhood Hits	446	Target Neighborhood Hits	1146	Shared Neighborhood Hits	169
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MLTK_HUMAN
θ value	0.00134147 (rank : 53)	NC score	0.078643 (rank : 422)
Query Neighborhood Hits	446	Target Neighborhood Hits	911	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

PSCBP_MOUSE
θ value	0.00134147 (rank : 54)	NC score	0.356978 (rank : 14)
Query Neighborhood Hits	446	Target Neighborhood Hits	118	Shared Neighborhood Hits	97
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

FRK_HUMAN
θ value	0.00175202 (rank : 55)	NC score	0.095046 (rank : 327)
Query Neighborhood Hits	446	Target Neighborhood Hits	1058	Shared Neighborhood Hits	142
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

NCK2_HUMAN
θ value	0.00175202 (rank : 56)	NC score	0.238912 (rank : 62)
Query Neighborhood Hits	446	Target Neighborhood Hits	310	Shared Neighborhood Hits	112
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

PRGR_MOUSE
θ value	0.00175202 (rank : 57)	NC score	0.039664 (rank : 756)
Query Neighborhood Hits	446	Target Neighborhood Hits	286	Shared Neighborhood Hits	27
SwissProt Accessions	Q00175	Gene names	Pgr, Nr3c3, Pr
Domain Architecture
Description	Progesterone receptor (PR).

SH3K1_MOUSE
θ value	0.00175202 (rank : 58)	NC score	0.280473 (rank : 40)
Query Neighborhood Hits	446	Target Neighborhood Hits	332	Shared Neighborhood Hits	130
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

GRB2_HUMAN
θ value	0.00228821 (rank : 59)	NC score	0.228967 (rank : 83)
Query Neighborhood Hits	446	Target Neighborhood Hits	310	Shared Neighborhood Hits	118
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	0.00228821 (rank : 60)	NC score	0.228942 (rank : 84)
Query Neighborhood Hits	446	Target Neighborhood Hits	312	Shared Neighborhood Hits	118
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

WHRN_HUMAN
θ value	0.00228821 (rank : 61)	NC score	0.321981 (rank : 16)
Query Neighborhood Hits	446	Target Neighborhood Hits	325	Shared Neighborhood Hits	135
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

WHRN_MOUSE
θ value	0.00228821 (rank : 62)	NC score	0.321419 (rank : 17)
Query Neighborhood Hits	446	Target Neighborhood Hits	412	Shared Neighborhood Hits	140
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

DLG2_MOUSE
θ value	0.00298849 (rank : 63)	NC score	0.233062 (rank : 79)
Query Neighborhood Hits	446	Target Neighborhood Hits	271	Shared Neighborhood Hits	149
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DNMBP_HUMAN
θ value	0.00298849 (rank : 64)	NC score	0.227913 (rank : 87)
Query Neighborhood Hits	446	Target Neighborhood Hits	413	Shared Neighborhood Hits	118
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

LIPB1_HUMAN
θ value	0.00298849 (rank : 65)	NC score	0.128102 (rank : 234)
Query Neighborhood Hits	446	Target Neighborhood Hits	640	Shared Neighborhood Hits	46
SwissProt Accessions	Q86W92, O75336, Q86X70, Q9NY03, Q9ULJ0	Gene names	PPFIBP1, KIAA1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2).

LIPB1_MOUSE
θ value	0.00298849 (rank : 66)	NC score	0.126941 (rank : 236)
Query Neighborhood Hits	446	Target Neighborhood Hits	727	Shared Neighborhood Hits	55
SwissProt Accessions	Q8C8U0, Q69ZN5, Q6GQV3, Q80VB4, Q9CUT7	Gene names	Ppfibp1, Kiaa1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1).

LNX1_HUMAN
θ value	0.00298849 (rank : 67)	NC score	0.239567 (rank : 59)
Query Neighborhood Hits	446	Target Neighborhood Hits	379	Shared Neighborhood Hits	102
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

NCK1_HUMAN
θ value	0.00298849 (rank : 68)	NC score	0.239458 (rank : 60)
Query Neighborhood Hits	446	Target Neighborhood Hits	312	Shared Neighborhood Hits	119
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

VAV3_MOUSE
θ value	0.00298849 (rank : 69)	NC score	0.235014 (rank : 72)
Query Neighborhood Hits	446	Target Neighborhood Hits	404	Shared Neighborhood Hits	116
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

EPHB3_MOUSE
θ value	0.00390308 (rank : 70)	NC score	0.089413 (rank : 348)
Query Neighborhood Hits	446	Target Neighborhood Hits	996	Shared Neighborhood Hits	76
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

M3K10_HUMAN
θ value	0.00390308 (rank : 71)	NC score	0.099955 (rank : 308)
Query Neighborhood Hits	446	Target Neighborhood Hits	1071	Shared Neighborhood Hits	145
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

MAST1_MOUSE
θ value	0.00390308 (rank : 72)	NC score	0.092550 (rank : 335)
Query Neighborhood Hits	446	Target Neighborhood Hits	1123	Shared Neighborhood Hits	166
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

FYN_HUMAN
θ value	0.00509761 (rank : 73)	NC score	0.108529 (rank : 276)
Query Neighborhood Hits	446	Target Neighborhood Hits	1078	Shared Neighborhood Hits	142
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	0.00509761 (rank : 74)	NC score	0.109536 (rank : 269)
Query Neighborhood Hits	446	Target Neighborhood Hits	1073	Shared Neighborhood Hits	143
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

LIPB2_HUMAN
θ value	0.00509761 (rank : 75)	NC score	0.129790 (rank : 229)
Query Neighborhood Hits	446	Target Neighborhood Hits	599	Shared Neighborhood Hits	43
SwissProt Accessions	Q8ND30, O75337, Q8WW26	Gene names	PPFIBP2
Domain Architecture
Description	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2).

LIPB2_MOUSE
θ value	0.00509761 (rank : 76)	NC score	0.131553 (rank : 225)
Query Neighborhood Hits	446	Target Neighborhood Hits	570	Shared Neighborhood Hits	46
SwissProt Accessions	O35711, Q7TMG4, Q8CBS6, Q99KX6	Gene names	Ppfibp2, Cclp1
Domain Architecture
Description	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) (Coiled-coil-like protein 1).

MY18A_HUMAN
θ value	0.00509761 (rank : 77)	NC score	0.076707 (rank : 434)
Query Neighborhood Hits	446	Target Neighborhood Hits	1929	Shared Neighborhood Hits	148
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

PDZD2_HUMAN
θ value	0.00509761 (rank : 78)	NC score	0.265826 (rank : 48)
Query Neighborhood Hits	446	Target Neighborhood Hits	772	Shared Neighborhood Hits	169
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

SH3G2_HUMAN
θ value	0.00509761 (rank : 79)	NC score	0.214827 (rank : 107)
Query Neighborhood Hits	446	Target Neighborhood Hits	324	Shared Neighborhood Hits	107
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

VAV3_HUMAN
θ value	0.00509761 (rank : 80)	NC score	0.235999 (rank : 69)
Query Neighborhood Hits	446	Target Neighborhood Hits	398	Shared Neighborhood Hits	115
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

M3KL4_HUMAN
θ value	0.00665767 (rank : 81)	NC score	0.108814 (rank : 274)
Query Neighborhood Hits	446	Target Neighborhood Hits	1087	Shared Neighborhood Hits	146
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

MAST4_HUMAN
θ value	0.00665767 (rank : 82)	NC score	0.098770 (rank : 314)
Query Neighborhood Hits	446	Target Neighborhood Hits	1804	Shared Neighborhood Hits	216
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

STAC_HUMAN
θ value	0.00665767 (rank : 83)	NC score	0.233115 (rank : 78)
Query Neighborhood Hits	446	Target Neighborhood Hits	276	Shared Neighborhood Hits	110
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ITSN1_MOUSE
θ value	0.00869519 (rank : 84)	NC score	0.183725 (rank : 146)
Query Neighborhood Hits	446	Target Neighborhood Hits	1669	Shared Neighborhood Hits	178
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

SI1L3_HUMAN
θ value	0.00869519 (rank : 85)	NC score	0.139095 (rank : 208)
Query Neighborhood Hits	446	Target Neighborhood Hits	305	Shared Neighborhood Hits	67
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

EPHB3_HUMAN
θ value	0.0113563 (rank : 86)	NC score	0.088429 (rank : 351)
Query Neighborhood Hits	446	Target Neighborhood Hits	996	Shared Neighborhood Hits	74
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

SH3G2_MOUSE
θ value	0.0113563 (rank : 87)	NC score	0.212386 (rank : 110)
Query Neighborhood Hits	446	Target Neighborhood Hits	319	Shared Neighborhood Hits	107
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

CD2AP_MOUSE
θ value	0.0148317 (rank : 88)	NC score	0.264108 (rank : 50)
Query Neighborhood Hits	446	Target Neighborhood Hits	336	Shared Neighborhood Hits	134
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

DLG2_HUMAN
θ value	0.0148317 (rank : 89)	NC score	0.235686 (rank : 71)
Query Neighborhood Hits	446	Target Neighborhood Hits	279	Shared Neighborhood Hits	153
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

EPHB2_HUMAN
θ value	0.0148317 (rank : 90)	NC score	0.086101 (rank : 362)
Query Neighborhood Hits	446	Target Neighborhood Hits	983	Shared Neighborhood Hits	71
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	0.0148317 (rank : 91)	NC score	0.085653 (rank : 363)
Query Neighborhood Hits	446	Target Neighborhood Hits	982	Shared Neighborhood Hits	71
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

RPGF2_HUMAN
θ value	0.0148317 (rank : 92)	NC score	0.187640 (rank : 141)
Query Neighborhood Hits	446	Target Neighborhood Hits	242	Shared Neighborhood Hits	108
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

SI1L1_HUMAN
θ value	0.0148317 (rank : 93)	NC score	0.131771 (rank : 223)
Query Neighborhood Hits	446	Target Neighborhood Hits	162	Shared Neighborhood Hits	41
SwissProt Accessions	O43166, O95321, Q9UDU4, Q9UNU4	Gene names	SIPA1L1, E6TP1, KIAA0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1 (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6- targeted protein 1).

SI1L1_MOUSE
θ value	0.0148317 (rank : 94)	NC score	0.133426 (rank : 218)
Query Neighborhood Hits	446	Target Neighborhood Hits	189	Shared Neighborhood Hits	42
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

STIM2_MOUSE
θ value	0.0148317 (rank : 95)	NC score	0.083725 (rank : 378)
Query Neighborhood Hits	446	Target Neighborhood Hits	403	Shared Neighborhood Hits	19
SwissProt Accessions	P83093, Q69ZI3, Q80VF4	Gene names	Stim2, Kiaa1482
Domain Architecture	No domain graphic available
Description	Stromal interaction molecule 2 precursor.

CSKI2_MOUSE
θ value	0.0193708 (rank : 96)	NC score	0.118215 (rank : 250)
Query Neighborhood Hits	446	Target Neighborhood Hits	812	Shared Neighborhood Hits	134
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

EPHA5_MOUSE
θ value	0.0193708 (rank : 97)	NC score	0.082924 (rank : 384)
Query Neighborhood Hits	446	Target Neighborhood Hits	950	Shared Neighborhood Hits	70
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

INADL_MOUSE
θ value	0.0193708 (rank : 98)	NC score	0.274730 (rank : 41)
Query Neighborhood Hits	446	Target Neighborhood Hits	290	Shared Neighborhood Hits	122
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

ITSN2_HUMAN
θ value	0.0193708 (rank : 99)	NC score	0.193278 (rank : 134)
Query Neighborhood Hits	446	Target Neighborhood Hits	1173	Shared Neighborhood Hits	152
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

LNX1_MOUSE
θ value	0.0193708 (rank : 100)	NC score	0.234492 (rank : 75)
Query Neighborhood Hits	446	Target Neighborhood Hits	377	Shared Neighborhood Hits	106
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

STIM2_HUMAN
θ value	0.0193708 (rank : 101)	NC score	0.082499 (rank : 387)
Query Neighborhood Hits	446	Target Neighborhood Hits	420	Shared Neighborhood Hits	21
SwissProt Accessions	Q9P246, Q96BF1, Q9BQH2, Q9H8R1	Gene names	STIM2, KIAA1482
Domain Architecture
Description	Stromal interaction molecule 2 precursor.

DLG3_HUMAN
θ value	0.0252991 (rank : 102)	NC score	0.236596 (rank : 68)
Query Neighborhood Hits	446	Target Neighborhood Hits	269	Shared Neighborhood Hits	148
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG3_MOUSE
θ value	0.0252991 (rank : 103)	NC score	0.237322 (rank : 66)
Query Neighborhood Hits	446	Target Neighborhood Hits	274	Shared Neighborhood Hits	150
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

ITSN2_MOUSE
θ value	0.0252991 (rank : 104)	NC score	0.185946 (rank : 144)
Query Neighborhood Hits	446	Target Neighborhood Hits	1371	Shared Neighborhood Hits	154
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

NEB1_HUMAN
θ value	0.0252991 (rank : 105)	NC score	0.187689 (rank : 140)
Query Neighborhood Hits	446	Target Neighborhood Hits	829	Shared Neighborhood Hits	120
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

INADL_HUMAN
θ value	0.0330416 (rank : 106)	NC score	0.272964 (rank : 42)
Query Neighborhood Hits	446	Target Neighborhood Hits	260	Shared Neighborhood Hits	118
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

LIN7B_HUMAN
θ value	0.0330416 (rank : 107)	NC score	0.294881 (rank : 28)
Query Neighborhood Hits	446	Target Neighborhood Hits	200	Shared Neighborhood Hits	115
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

LIN7B_MOUSE
θ value	0.0330416 (rank : 108)	NC score	0.293284 (rank : 30)
Query Neighborhood Hits	446	Target Neighborhood Hits	200	Shared Neighborhood Hits	115
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

NCF1_HUMAN
θ value	0.0330416 (rank : 109)	NC score	0.228516 (rank : 86)
Query Neighborhood Hits	446	Target Neighborhood Hits	198	Shared Neighborhood Hits	102
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

RIMB2_MOUSE
θ value	0.0330416 (rank : 110)	NC score	0.171419 (rank : 169)
Query Neighborhood Hits	446	Target Neighborhood Hits	246	Shared Neighborhood Hits	80
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

PDZD7_HUMAN
θ value	0.0431538 (rank : 111)	NC score	0.321107 (rank : 18)
Query Neighborhood Hits	446	Target Neighborhood Hits	181	Shared Neighborhood Hits	114
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

RIMB2_HUMAN
θ value	0.0431538 (rank : 112)	NC score	0.169007 (rank : 173)
Query Neighborhood Hits	446	Target Neighborhood Hits	263	Shared Neighborhood Hits	85
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SI1L2_HUMAN
θ value	0.0431538 (rank : 113)	NC score	0.134808 (rank : 215)
Query Neighborhood Hits	446	Target Neighborhood Hits	131	Shared Neighborhood Hits	43
SwissProt Accessions	Q9P2F8, Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6	Gene names	SIPA1L2, KIAA1389
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

YES_HUMAN
θ value	0.0431538 (rank : 114)	NC score	0.104463 (rank : 293)
Query Neighborhood Hits	446	Target Neighborhood Hits	1059	Shared Neighborhood Hits	145
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

APBA1_HUMAN
θ value	0.0563607 (rank : 115)	NC score	0.225851 (rank : 93)
Query Neighborhood Hits	446	Target Neighborhood Hits	325	Shared Neighborhood Hits	115
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

CD2AP_HUMAN
θ value	0.0563607 (rank : 116)	NC score	0.260107 (rank : 51)
Query Neighborhood Hits	446	Target Neighborhood Hits	315	Shared Neighborhood Hits	126
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CNKR1_HUMAN
θ value	0.0563607 (rank : 117)	NC score	0.140965 (rank : 207)
Query Neighborhood Hits	446	Target Neighborhood Hits	154	Shared Neighborhood Hits	32
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CSKI1_HUMAN
θ value	0.0563607 (rank : 118)	NC score	0.111506 (rank : 262)
Query Neighborhood Hits	446	Target Neighborhood Hits	997	Shared Neighborhood Hits	148
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

DLG1_HUMAN
θ value	0.0563607 (rank : 119)	NC score	0.233615 (rank : 77)
Query Neighborhood Hits	446	Target Neighborhood Hits	290	Shared Neighborhood Hits	152
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

HCLS1_MOUSE
θ value	0.0563607 (rank : 120)	NC score	0.222839 (rank : 101)
Query Neighborhood Hits	446	Target Neighborhood Hits	329	Shared Neighborhood Hits	121
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

ITSN1_HUMAN
θ value	0.0563607 (rank : 121)	NC score	0.180733 (rank : 152)
Query Neighborhood Hits	446	Target Neighborhood Hits	1757	Shared Neighborhood Hits	176
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

MLL3_HUMAN
θ value	0.0563607 (rank : 122)	NC score	0.062072 (rank : 547)
Query Neighborhood Hits	446	Target Neighborhood Hits	1644	Shared Neighborhood Hits	118
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

RIMB1_HUMAN
θ value	0.0563607 (rank : 123)	NC score	0.122025 (rank : 243)
Query Neighborhood Hits	446	Target Neighborhood Hits	1479	Shared Neighborhood Hits	167
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RPGF6_HUMAN
θ value	0.0563607 (rank : 124)	NC score	0.198702 (rank : 123)
Query Neighborhood Hits	446	Target Neighborhood Hits	266	Shared Neighborhood Hits	113
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

APBA2_HUMAN
θ value	0.0736092 (rank : 125)	NC score	0.223702 (rank : 98)
Query Neighborhood Hits	446	Target Neighborhood Hits	220	Shared Neighborhood Hits	108
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_MOUSE
θ value	0.0736092 (rank : 126)	NC score	0.224275 (rank : 95)
Query Neighborhood Hits	446	Target Neighborhood Hits	219	Shared Neighborhood Hits	109
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA3_HUMAN
θ value	0.0736092 (rank : 127)	NC score	0.234012 (rank : 76)
Query Neighborhood Hits	446	Target Neighborhood Hits	201	Shared Neighborhood Hits	110
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

CSKI1_MOUSE
θ value	0.0736092 (rank : 128)	NC score	0.112205 (rank : 261)
Query Neighborhood Hits	446	Target Neighborhood Hits	1031	Shared Neighborhood Hits	146
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI2_HUMAN
θ value	0.0736092 (rank : 129)	NC score	0.120451 (rank : 247)
Query Neighborhood Hits	446	Target Neighborhood Hits	747	Shared Neighborhood Hits	134
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

DLG1_MOUSE
θ value	0.0736092 (rank : 130)	NC score	0.229772 (rank : 82)
Query Neighborhood Hits	446	Target Neighborhood Hits	285	Shared Neighborhood Hits	147
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

LIN7A_HUMAN
θ value	0.0736092 (rank : 131)	NC score	0.291959 (rank : 32)
Query Neighborhood Hits	446	Target Neighborhood Hits	193	Shared Neighborhood Hits	117
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7A_MOUSE
θ value	0.0736092 (rank : 132)	NC score	0.293936 (rank : 29)
Query Neighborhood Hits	446	Target Neighborhood Hits	193	Shared Neighborhood Hits	117
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

MUC1_HUMAN
θ value	0.0736092 (rank : 133)	NC score	0.081420 (rank : 397)
Query Neighborhood Hits	446	Target Neighborhood Hits	975	Shared Neighborhood Hits	95
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

OSTF1_HUMAN
θ value	0.0736092 (rank : 134)	NC score	0.197141 (rank : 127)
Query Neighborhood Hits	446	Target Neighborhood Hits	466	Shared Neighborhood Hits	125
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

PO6F1_MOUSE
θ value	0.0736092 (rank : 135)	NC score	0.023373 (rank : 795)
Query Neighborhood Hits	446	Target Neighborhood Hits	581	Shared Neighborhood Hits	32
SwissProt Accessions	Q07916, Q91XK3	Gene names	Pou6f1, Emb
Domain Architecture
Description	POU domain, class 6, transcription factor 1 (Octamer-binding transcription factor EMB) (Transcription regulatory protein MCP-1).

SARM1_HUMAN
θ value	0.0736092 (rank : 136)	NC score	0.135687 (rank : 212)
Query Neighborhood Hits	446	Target Neighborhood Hits	58	Shared Neighborhood Hits	28
SwissProt Accessions	Q6SZW1, O60277, Q7LGG3, Q9NXY5	Gene names	SARM1, KIAA0524, SARM
Domain Architecture	No domain graphic available
Description	Sterile alpha and TIR motif-containing protein 1 (Sterile alpha and Armadillo repeat protein) (Tir-1 homolog).

SEPT9_HUMAN
θ value	0.0736092 (rank : 137)	NC score	0.037037 (rank : 764)
Query Neighborhood Hits	446	Target Neighborhood Hits	706	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

SH3G1_HUMAN
θ value	0.0736092 (rank : 138)	NC score	0.199337 (rank : 122)
Query Neighborhood Hits	446	Target Neighborhood Hits	307	Shared Neighborhood Hits	108
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SI1L2_MOUSE
θ value	0.0736092 (rank : 139)	NC score	0.131793 (rank : 222)
Query Neighborhood Hits	446	Target Neighborhood Hits	124	Shared Neighborhood Hits	43
SwissProt Accessions	Q80TE4, Q6PDY1	Gene names	Sipa1l2, Kiaa0545
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

USH1C_HUMAN
θ value	0.0736092 (rank : 140)	NC score	0.308157 (rank : 20)
Query Neighborhood Hits	446	Target Neighborhood Hits	327	Shared Neighborhood Hits	128
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

USH1C_MOUSE
θ value	0.0736092 (rank : 141)	NC score	0.300019 (rank : 27)
Query Neighborhood Hits	446	Target Neighborhood Hits	557	Shared Neighborhood Hits	144
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

VINEX_MOUSE
θ value	0.0736092 (rank : 142)	NC score	0.222336 (rank : 102)
Query Neighborhood Hits	446	Target Neighborhood Hits	286	Shared Neighborhood Hits	111
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

EFS_MOUSE
θ value	0.0961366 (rank : 143)	NC score	0.150981 (rank : 191)
Query Neighborhood Hits	446	Target Neighborhood Hits	389	Shared Neighborhood Hits	125
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

LIN7C_HUMAN
θ value	0.0961366 (rank : 144)	NC score	0.287563 (rank : 38)
Query Neighborhood Hits	446	Target Neighborhood Hits	198	Shared Neighborhood Hits	115
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
θ value	0.0961366 (rank : 145)	NC score	0.287563 (rank : 39)
Query Neighborhood Hits	446	Target Neighborhood Hits	198	Shared Neighborhood Hits	115
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

OSTF1_MOUSE
θ value	0.0961366 (rank : 146)	NC score	0.194033 (rank : 132)
Query Neighborhood Hits	446	Target Neighborhood Hits	467	Shared Neighborhood Hits	123
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

SARM1_MOUSE
θ value	0.0961366 (rank : 147)	NC score	0.148266 (rank : 198)
Query Neighborhood Hits	446	Target Neighborhood Hits	54	Shared Neighborhood Hits	33
SwissProt Accessions	Q6PDS3, Q5SYG5, Q5SYG6, Q6A054, Q6SZW0, Q8BRI9	Gene names	Sarm1, Kiaa0524
Domain Architecture	No domain graphic available
Description	Sterile alpha and TIR motif-containing protein 1 (Tir-1 homolog).

SRC8_HUMAN
θ value	0.0961366 (rank : 148)	NC score	0.224329 (rank : 94)
Query Neighborhood Hits	446	Target Neighborhood Hits	269	Shared Neighborhood Hits	109
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	0.0961366 (rank : 149)	NC score	0.223421 (rank : 99)
Query Neighborhood Hits	446	Target Neighborhood Hits	292	Shared Neighborhood Hits	114
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SYP2L_HUMAN
θ value	0.0961366 (rank : 150)	NC score	0.216906 (rank : 105)
Query Neighborhood Hits	446	Target Neighborhood Hits	400	Shared Neighborhood Hits	139
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

TXND2_HUMAN
θ value	0.0961366 (rank : 151)	NC score	0.064293 (rank : 526)
Query Neighborhood Hits	446	Target Neighborhood Hits	793	Shared Neighborhood Hits	73
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

AHI1_MOUSE
θ value	0.125558 (rank : 152)	NC score	0.142037 (rank : 206)
Query Neighborhood Hits	446	Target Neighborhood Hits	496	Shared Neighborhood Hits	109
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ANKS1_HUMAN
θ value	0.125558 (rank : 153)	NC score	0.086731 (rank : 357)
Query Neighborhood Hits	446	Target Neighborhood Hits	438	Shared Neighborhood Hits	62
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

ARHG5_HUMAN
θ value	0.125558 (rank : 154)	NC score	0.134567 (rank : 217)
Query Neighborhood Hits	446	Target Neighborhood Hits	172	Shared Neighborhood Hits	76
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

PDLI7_HUMAN
θ value	0.125558 (rank : 155)	NC score	0.115924 (rank : 253)
Query Neighborhood Hits	446	Target Neighborhood Hits	547	Shared Neighborhood Hits	115
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PDLI7_MOUSE
θ value	0.125558 (rank : 156)	NC score	0.112859 (rank : 259)
Query Neighborhood Hits	446	Target Neighborhood Hits	279	Shared Neighborhood Hits	85
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PPIP1_HUMAN
θ value	0.125558 (rank : 157)	NC score	0.175658 (rank : 160)
Query Neighborhood Hits	446	Target Neighborhood Hits	389	Shared Neighborhood Hits	113
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

TCGAP_MOUSE
θ value	0.125558 (rank : 158)	NC score	0.113417 (rank : 258)
Query Neighborhood Hits	446	Target Neighborhood Hits	409	Shared Neighborhood Hits	112
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ANR11_HUMAN
θ value	0.163984 (rank : 159)	NC score	0.066555 (rank : 513)
Query Neighborhood Hits	446	Target Neighborhood Hits	1289	Shared Neighborhood Hits	104
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

BLNK_MOUSE
θ value	0.163984 (rank : 160)	NC score	0.103188 (rank : 296)
Query Neighborhood Hits	446	Target Neighborhood Hits	296	Shared Neighborhood Hits	63
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

DNMBP_MOUSE
θ value	0.163984 (rank : 161)	NC score	0.223051 (rank : 100)
Query Neighborhood Hits	446	Target Neighborhood Hits	435	Shared Neighborhood Hits	128
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

GRAP_MOUSE
θ value	0.163984 (rank : 162)	NC score	0.223820 (rank : 97)
Query Neighborhood Hits	446	Target Neighborhood Hits	309	Shared Neighborhood Hits	123
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

LPP_HUMAN
θ value	0.163984 (rank : 163)	NC score	0.051116 (rank : 710)
Query Neighborhood Hits	446	Target Neighborhood Hits	775	Shared Neighborhood Hits	73
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

SAM10_MOUSE
θ value	0.163984 (rank : 164)	NC score	0.135071 (rank : 214)
Query Neighborhood Hits	446	Target Neighborhood Hits	23	Shared Neighborhood Hits	17
SwissProt Accessions	Q7TST3	Gene names	Samd10
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 10.

SELPL_MOUSE
θ value	0.163984 (rank : 165)	NC score	0.081279 (rank : 398)
Query Neighborhood Hits	446	Target Neighborhood Hits	588	Shared Neighborhood Hits	72
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

SNTG1_MOUSE
θ value	0.163984 (rank : 166)	NC score	0.237602 (rank : 64)
Query Neighborhood Hits	446	Target Neighborhood Hits	179	Shared Neighborhood Hits	109
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNX27_HUMAN
θ value	0.163984 (rank : 167)	NC score	0.080717 (rank : 406)
Query Neighborhood Hits	446	Target Neighborhood Hits	54	Shared Neighborhood Hits	13
SwissProt Accessions	Q96L92	Gene names	SNX27
Domain Architecture
Description	Sorting nexin-27.

TCGAP_HUMAN
θ value	0.163984 (rank : 168)	NC score	0.109209 (rank : 271)
Query Neighborhood Hits	446	Target Neighborhood Hits	872	Shared Neighborhood Hits	135
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

BCAS1_MOUSE
θ value	0.21417 (rank : 169)	NC score	0.054808 (rank : 646)
Query Neighborhood Hits	446	Target Neighborhood Hits	215	Shared Neighborhood Hits	30
SwissProt Accessions	Q80YN3, Q9CVA1	Gene names	Bcas1, Nabc1
Domain Architecture	No domain graphic available
Description	Breast carcinoma amplified sequence 1 homolog (Novel amplified in breast cancer 1 homolog).

DCC_MOUSE
θ value	0.21417 (rank : 170)	NC score	0.026177 (rank : 784)
Query Neighborhood Hits	446	Target Neighborhood Hits	896	Shared Neighborhood Hits	68
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

GRAP_HUMAN
θ value	0.21417 (rank : 171)	NC score	0.219904 (rank : 104)
Query Neighborhood Hits	446	Target Neighborhood Hits	307	Shared Neighborhood Hits	123
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

HCLS1_HUMAN
θ value	0.21417 (rank : 172)	NC score	0.214474 (rank : 109)
Query Neighborhood Hits	446	Target Neighborhood Hits	358	Shared Neighborhood Hits	120
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

MPDZ_HUMAN
θ value	0.21417 (rank : 173)	NC score	0.266389 (rank : 47)
Query Neighborhood Hits	446	Target Neighborhood Hits	261	Shared Neighborhood Hits	124
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

MPDZ_MOUSE
θ value	0.21417 (rank : 174)	NC score	0.267205 (rank : 46)
Query Neighborhood Hits	446	Target Neighborhood Hits	298	Shared Neighborhood Hits	124
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

NACAM_MOUSE
θ value	0.21417 (rank : 175)	NC score	0.105537 (rank : 286)
Query Neighborhood Hits	446	Target Neighborhood Hits	1866	Shared Neighborhood Hits	166
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

PZRN3_MOUSE
θ value	0.21417 (rank : 176)	NC score	0.187112 (rank : 142)
Query Neighborhood Hits	446	Target Neighborhood Hits	447	Shared Neighborhood Hits	104
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

SAPS1_HUMAN
θ value	0.21417 (rank : 177)	NC score	0.061081 (rank : 558)
Query Neighborhood Hits	446	Target Neighborhood Hits	704	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

SNTG1_HUMAN
θ value	0.21417 (rank : 178)	NC score	0.237055 (rank : 67)
Query Neighborhood Hits	446	Target Neighborhood Hits	181	Shared Neighborhood Hits	109
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

TENX_HUMAN
θ value	0.21417 (rank : 179)	NC score	0.015623 (rank : 821)
Query Neighborhood Hits	446	Target Neighborhood Hits	789	Shared Neighborhood Hits	45
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

TX1B3_HUMAN
θ value	0.21417 (rank : 180)	NC score	0.291319 (rank : 34)
Query Neighborhood Hits	446	Target Neighborhood Hits	161	Shared Neighborhood Hits	105
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
θ value	0.21417 (rank : 181)	NC score	0.291343 (rank : 33)
Query Neighborhood Hits	446	Target Neighborhood Hits	158	Shared Neighborhood Hits	105
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

AMBN_HUMAN
θ value	0.279714 (rank : 182)	NC score	0.043254 (rank : 748)
Query Neighborhood Hits	446	Target Neighborhood Hits	107	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NP70, Q9H2X1, Q9H4L1	Gene names	AMBN
Domain Architecture
Description	Ameloblastin precursor.

APBA3_MOUSE
θ value	0.279714 (rank : 183)	NC score	0.220679 (rank : 103)
Query Neighborhood Hits	446	Target Neighborhood Hits	174	Shared Neighborhood Hits	105
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

C1QR1_HUMAN
θ value	0.279714 (rank : 184)	NC score	0.009353 (rank : 836)
Query Neighborhood Hits	446	Target Neighborhood Hits	493	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NPY3, O00274	Gene names	CD93, C1QR1, MXRA4
Domain Architecture
Description	Complement component C1q receptor precursor (Complement component 1 q subcomponent receptor 1) (C1qR) (C1qRp) (C1qR(p)) (C1q/MBL/SPA receptor) (CD93 antigen) (CDw93).

EPHA6_MOUSE
θ value	0.279714 (rank : 185)	NC score	0.082585 (rank : 386)
Query Neighborhood Hits	446	Target Neighborhood Hits	946	Shared Neighborhood Hits	67
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA7_MOUSE
θ value	0.279714 (rank : 186)	NC score	0.080868 (rank : 403)
Query Neighborhood Hits	446	Target Neighborhood Hits	1025	Shared Neighborhood Hits	71
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHB4_HUMAN
θ value	0.279714 (rank : 187)	NC score	0.081457 (rank : 396)
Query Neighborhood Hits	446	Target Neighborhood Hits	1056	Shared Neighborhood Hits	73
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

MYCB2_HUMAN
θ value	0.279714 (rank : 188)	NC score	0.032971 (rank : 774)
Query Neighborhood Hits	446	Target Neighborhood Hits	390	Shared Neighborhood Hits	34
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

SAM10_HUMAN
θ value	0.279714 (rank : 189)	NC score	0.133316 (rank : 220)
Query Neighborhood Hits	446	Target Neighborhood Hits	20	Shared Neighborhood Hits	17
SwissProt Accessions	Q9BYL1	Gene names	SAMD10, C20orf136
Domain Architecture
Description	Sterile alpha motif domain-containing protein 10.

SRC_HUMAN
θ value	0.279714 (rank : 190)	NC score	0.102243 (rank : 300)
Query Neighborhood Hits	446	Target Neighborhood Hits	1058	Shared Neighborhood Hits	145
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

CAC1G_HUMAN
θ value	0.365318 (rank : 191)	NC score	0.033074 (rank : 773)
Query Neighborhood Hits	446	Target Neighborhood Hits	587	Shared Neighborhood Hits	61
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

EPHA6_HUMAN
θ value	0.365318 (rank : 192)	NC score	0.086205 (rank : 360)
Query Neighborhood Hits	446	Target Neighborhood Hits	959	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA7_HUMAN
θ value	0.365318 (rank : 193)	NC score	0.080655 (rank : 407)
Query Neighborhood Hits	446	Target Neighborhood Hits	1053	Shared Neighborhood Hits	75
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

NCOA6_HUMAN
θ value	0.365318 (rank : 194)	NC score	0.084681 (rank : 371)
Query Neighborhood Hits	446	Target Neighborhood Hits	1202	Shared Neighborhood Hits	115
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

PARD3_HUMAN
θ value	0.365318 (rank : 195)	NC score	0.240219 (rank : 58)
Query Neighborhood Hits	446	Target Neighborhood Hits	312	Shared Neighborhood Hits	110
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

PRRT3_MOUSE
θ value	0.365318 (rank : 196)	NC score	0.078305 (rank : 425)
Query Neighborhood Hits	446	Target Neighborhood Hits	162	Shared Neighborhood Hits	25
SwissProt Accessions	Q6PE13	Gene names	Prrt3
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

REPS2_MOUSE
θ value	0.365318 (rank : 197)	NC score	0.079809 (rank : 413)
Query Neighborhood Hits	446	Target Neighborhood Hits	102	Shared Neighborhood Hits	21
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

AHI1_HUMAN
θ value	0.47712 (rank : 198)	NC score	0.142208 (rank : 205)
Query Neighborhood Hits	446	Target Neighborhood Hits	537	Shared Neighborhood Hits	109
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

K1802_HUMAN
θ value	0.47712 (rank : 199)	NC score	0.055177 (rank : 638)
Query Neighborhood Hits	446	Target Neighborhood Hits	1378	Shared Neighborhood Hits	108
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

OGFR_HUMAN
θ value	0.47712 (rank : 200)	NC score	0.074607 (rank : 452)
Query Neighborhood Hits	446	Target Neighborhood Hits	1582	Shared Neighborhood Hits	118
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

PF21A_HUMAN
θ value	0.47712 (rank : 201)	NC score	0.043407 (rank : 747)
Query Neighborhood Hits	446	Target Neighborhood Hits	303	Shared Neighborhood Hits	20
SwissProt Accessions	Q96BD5, Q6AWA2, Q9C0G7, Q9H8V9, Q9HAK6, Q9NZE9	Gene names	PHF21A, BHC80, KIAA1696
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (BHC80a).

PLXB1_MOUSE
θ value	0.47712 (rank : 202)	NC score	0.019514 (rank : 803)
Query Neighborhood Hits	446	Target Neighborhood Hits	259	Shared Neighborhood Hits	28
SwissProt Accessions	Q8CJH3, Q6ZQC3, Q80ZZ1	Gene names	Plxnb1, Kiaa0407
Domain Architecture	No domain graphic available
Description	Plexin-B1 precursor.

PZRN3_HUMAN
θ value	0.47712 (rank : 203)	NC score	0.181216 (rank : 151)
Query Neighborhood Hits	446	Target Neighborhood Hits	461	Shared Neighborhood Hits	103
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

RTP3_MOUSE
θ value	0.47712 (rank : 204)	NC score	0.082437 (rank : 389)
Query Neighborhood Hits	446	Target Neighborhood Hits	374	Shared Neighborhood Hits	52
SwissProt Accessions	Q5QGU6, Q8VDC2	Gene names	Rtp3, Tmem7
Domain Architecture	No domain graphic available
Description	Receptor-transporting protein 3 (Transmembrane protein 7).

SH3G3_MOUSE
θ value	0.47712 (rank : 205)	NC score	0.202224 (rank : 118)
Query Neighborhood Hits	446	Target Neighborhood Hits	236	Shared Neighborhood Hits	102
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

TCOF_HUMAN
θ value	0.47712 (rank : 206)	NC score	0.074178 (rank : 458)
Query Neighborhood Hits	446	Target Neighborhood Hits	543	Shared Neighborhood Hits	68
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

ANK2_HUMAN
θ value	0.62314 (rank : 207)	NC score	0.062017 (rank : 548)
Query Neighborhood Hits	446	Target Neighborhood Hits	1615	Shared Neighborhood Hits	135
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

ARHG9_HUMAN
θ value	0.62314 (rank : 208)	NC score	0.182223 (rank : 148)
Query Neighborhood Hits	446	Target Neighborhood Hits	235	Shared Neighborhood Hits	107
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

BLNK_HUMAN
θ value	0.62314 (rank : 209)	NC score	0.087610 (rank : 353)
Query Neighborhood Hits	446	Target Neighborhood Hits	228	Shared Neighborhood Hits	45
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

CEND3_HUMAN
θ value	0.62314 (rank : 210)	NC score	0.056202 (rank : 621)
Query Neighborhood Hits	446	Target Neighborhood Hits	275	Shared Neighborhood Hits	58
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

EPHB4_MOUSE
θ value	0.62314 (rank : 211)	NC score	0.080306 (rank : 408)
Query Neighborhood Hits	446	Target Neighborhood Hits	1013	Shared Neighborhood Hits	71
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

K1802_MOUSE
θ value	0.62314 (rank : 212)	NC score	0.056138 (rank : 622)
Query Neighborhood Hits	446	Target Neighborhood Hits	1596	Shared Neighborhood Hits	112
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MAML2_HUMAN
θ value	0.62314 (rank : 213)	NC score	0.042931 (rank : 749)
Query Neighborhood Hits	446	Target Neighborhood Hits	360	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IZL2, Q6AI23, Q6Y3A3, Q8IUL3, Q96JK6	Gene names	MAML2, KIAA1819
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 2 (Mam-2).

NMDE3_MOUSE
θ value	0.62314 (rank : 214)	NC score	0.015526 (rank : 822)
Query Neighborhood Hits	446	Target Neighborhood Hits	86	Shared Neighborhood Hits	12
SwissProt Accessions	Q01098	Gene names	Grin2c
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 3 precursor (N-methyl D- aspartate receptor subtype 2C) (NR2C) (NMDAR2C).

NOL1_HUMAN
θ value	0.62314 (rank : 215)	NC score	0.044652 (rank : 745)
Query Neighborhood Hits	446	Target Neighborhood Hits	74	Shared Neighborhood Hits	10
SwissProt Accessions	P46087	Gene names	NOL1
Domain Architecture
Description	Proliferating-cell nucleolar antigen p120 (Proliferation-associated nucleolar protein p120).

PLCG2_HUMAN
θ value	0.62314 (rank : 216)	NC score	0.154251 (rank : 188)
Query Neighborhood Hits	446	Target Neighborhood Hits	280	Shared Neighborhood Hits	98
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP1_MOUSE
θ value	0.62314 (rank : 217)	NC score	0.174127 (rank : 164)
Query Neighborhood Hits	446	Target Neighborhood Hits	377	Shared Neighborhood Hits	119
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

RGS12_HUMAN
θ value	0.62314 (rank : 218)	NC score	0.156586 (rank : 184)
Query Neighborhood Hits	446	Target Neighborhood Hits	333	Shared Neighborhood Hits	119
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

SH3G1_MOUSE
θ value	0.62314 (rank : 219)	NC score	0.194732 (rank : 130)
Query Neighborhood Hits	446	Target Neighborhood Hits	291	Shared Neighborhood Hits	108
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SNTA1_HUMAN
θ value	0.62314 (rank : 220)	NC score	0.200819 (rank : 120)
Query Neighborhood Hits	446	Target Neighborhood Hits	186	Shared Neighborhood Hits	107
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

YES_MOUSE
θ value	0.62314 (rank : 221)	NC score	0.103805 (rank : 294)
Query Neighborhood Hits	446	Target Neighborhood Hits	1052	Shared Neighborhood Hits	144
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

CEND3_MOUSE
θ value	0.813845 (rank : 222)	NC score	0.050588 (rank : 720)
Query Neighborhood Hits	446	Target Neighborhood Hits	228	Shared Neighborhood Hits	49
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

EPHB1_HUMAN
θ value	0.813845 (rank : 223)	NC score	0.080726 (rank : 405)
Query Neighborhood Hits	446	Target Neighborhood Hits	988	Shared Neighborhood Hits	72
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

LCK_HUMAN
θ value	0.813845 (rank : 224)	NC score	0.084890 (rank : 370)
Query Neighborhood Hits	446	Target Neighborhood Hits	987	Shared Neighborhood Hits	106
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

M3K9_HUMAN
θ value	0.813845 (rank : 225)	NC score	0.100278 (rank : 305)
Query Neighborhood Hits	446	Target Neighborhood Hits	1123	Shared Neighborhood Hits	144
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

NCF1_MOUSE
θ value	0.813845 (rank : 226)	NC score	0.210419 (rank : 112)
Query Neighborhood Hits	446	Target Neighborhood Hits	198	Shared Neighborhood Hits	102
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NUCL_HUMAN
θ value	0.813845 (rank : 227)	NC score	0.021272 (rank : 799)
Query Neighborhood Hits	446	Target Neighborhood Hits	415	Shared Neighborhood Hits	25
SwissProt Accessions	P19338, Q53SK1, Q8NB06	Gene names	NCL
Domain Architecture
Description	Nucleolin (Protein C23).

PRR12_HUMAN
θ value	0.813845 (rank : 228)	NC score	0.089340 (rank : 349)
Query Neighborhood Hits	446	Target Neighborhood Hits	460	Shared Neighborhood Hits	87
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

RHPN1_HUMAN
θ value	0.813845 (rank : 229)	NC score	0.200690 (rank : 121)
Query Neighborhood Hits	446	Target Neighborhood Hits	158	Shared Neighborhood Hits	96
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

SH22A_MOUSE
θ value	0.813845 (rank : 230)	NC score	0.063769 (rank : 532)
Query Neighborhood Hits	446	Target Neighborhood Hits	179	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SNTG2_HUMAN
θ value	0.813845 (rank : 231)	NC score	0.226846 (rank : 90)
Query Neighborhood Hits	446	Target Neighborhood Hits	191	Shared Neighborhood Hits	115
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

VINEX_HUMAN
θ value	0.813845 (rank : 232)	NC score	0.216195 (rank : 106)
Query Neighborhood Hits	446	Target Neighborhood Hits	270	Shared Neighborhood Hits	111
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

ABL1_HUMAN
θ value	1.06291 (rank : 233)	NC score	0.090586 (rank : 342)
Query Neighborhood Hits	446	Target Neighborhood Hits	1220	Shared Neighborhood Hits	145
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	1.06291 (rank : 234)	NC score	0.091826 (rank : 337)
Query Neighborhood Hits	446	Target Neighborhood Hits	1178	Shared Neighborhood Hits	149
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
θ value	1.06291 (rank : 235)	NC score	0.087402 (rank : 354)
Query Neighborhood Hits	446	Target Neighborhood Hits	1045	Shared Neighborhood Hits	112
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

AIM1_HUMAN
θ value	1.06291 (rank : 236)	NC score	0.034667 (rank : 766)
Query Neighborhood Hits	446	Target Neighborhood Hits	247	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y4K1, O00296, Q5VWJ2	Gene names	AIM1
Domain Architecture
Description	Absent in melanoma 1 protein.

ARHG9_MOUSE
θ value	1.06291 (rank : 237)	NC score	0.182189 (rank : 149)
Query Neighborhood Hits	446	Target Neighborhood Hits	234	Shared Neighborhood Hits	105
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

FGR_HUMAN
θ value	1.06291 (rank : 238)	NC score	0.104953 (rank : 290)
Query Neighborhood Hits	446	Target Neighborhood Hits	1067	Shared Neighborhood Hits	143
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

K1543_HUMAN
θ value	1.06291 (rank : 239)	NC score	0.052651 (rank : 683)
Query Neighborhood Hits	446	Target Neighborhood Hits	435	Shared Neighborhood Hits	56
SwissProt Accessions	Q9P1Y5, Q8NDF1	Gene names	KIAA1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

NUAK1_HUMAN
θ value	1.06291 (rank : 240)	NC score	0.037355 (rank : 763)
Query Neighborhood Hits	446	Target Neighborhood Hits	874	Shared Neighborhood Hits	54
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

PARD3_MOUSE
θ value	1.06291 (rank : 241)	NC score	0.237484 (rank : 65)
Query Neighborhood Hits	446	Target Neighborhood Hits	290	Shared Neighborhood Hits	108
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

PRRT3_HUMAN
θ value	1.06291 (rank : 242)	NC score	0.093554 (rank : 333)
Query Neighborhood Hits	446	Target Neighborhood Hits	998	Shared Neighborhood Hits	104
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

SDCB2_MOUSE
θ value	1.06291 (rank : 243)	NC score	0.174619 (rank : 163)
Query Neighborhood Hits	446	Target Neighborhood Hits	118	Shared Neighborhood Hits	82
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

SNTA1_MOUSE
θ value	1.06291 (rank : 244)	NC score	0.195856 (rank : 129)
Query Neighborhood Hits	446	Target Neighborhood Hits	170	Shared Neighborhood Hits	104
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

TNKS1_HUMAN
θ value	1.06291 (rank : 245)	NC score	0.053768 (rank : 661)
Query Neighborhood Hits	446	Target Neighborhood Hits	477	Shared Neighborhood Hits	54
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

ANKS1_MOUSE
θ value	1.38821 (rank : 246)	NC score	0.082087 (rank : 390)
Query Neighborhood Hits	446	Target Neighborhood Hits	453	Shared Neighborhood Hits	65
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

BCL9_HUMAN
θ value	1.38821 (rank : 247)	NC score	0.061859 (rank : 552)
Query Neighborhood Hits	446	Target Neighborhood Hits	1008	Shared Neighborhood Hits	102
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

BRE1B_HUMAN
θ value	1.38821 (rank : 248)	NC score	0.024490 (rank : 791)
Query Neighborhood Hits	446	Target Neighborhood Hits	1040	Shared Neighborhood Hits	38
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

CRK_MOUSE
θ value	1.38821 (rank : 249)	NC score	0.181375 (rank : 150)
Query Neighborhood Hits	446	Target Neighborhood Hits	314	Shared Neighborhood Hits	118
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

FUT8_MOUSE
θ value	1.38821 (rank : 250)	NC score	0.057426 (rank : 600)
Query Neighborhood Hits	446	Target Neighborhood Hits	115	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WTS2, Q921U1	Gene names	Fut8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

GCNL2_MOUSE
θ value	1.38821 (rank : 251)	NC score	0.024878 (rank : 789)
Query Neighborhood Hits	446	Target Neighborhood Hits	146	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JHD2	Gene names	Gcn5l2
Domain Architecture
Description	General control of amino acid synthesis protein 5-like 2 (EC 2.3.1.48) (Histone acetyltransferase GCN5) (mmGCN5).

GPTC8_HUMAN
θ value	1.38821 (rank : 252)	NC score	0.038546 (rank : 759)
Query Neighborhood Hits	446	Target Neighborhood Hits	366	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UKJ3, O60300	Gene names	GPATC8, KIAA0553
Domain Architecture	No domain graphic available
Description	G patch domain-containing protein 8.

GRAP2_HUMAN
θ value	1.38821 (rank : 253)	NC score	0.197424 (rank : 126)
Query Neighborhood Hits	446	Target Neighborhood Hits	304	Shared Neighborhood Hits	117
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

K0319_HUMAN
θ value	1.38821 (rank : 254)	NC score	0.037564 (rank : 762)
Query Neighborhood Hits	446	Target Neighborhood Hits	154	Shared Neighborhood Hits	21
SwissProt Accessions	Q5VV43, Q9UJC8, Q9Y4G7	Gene names	KIAA0319
Domain Architecture	No domain graphic available
Description	Protein KIAA0319 precursor.

K1849_HUMAN
θ value	1.38821 (rank : 255)	NC score	0.196330 (rank : 128)
Query Neighborhood Hits	446	Target Neighborhood Hits	220	Shared Neighborhood Hits	102
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

MDC1_HUMAN
θ value	1.38821 (rank : 256)	NC score	0.084469 (rank : 373)
Query Neighborhood Hits	446	Target Neighborhood Hits	1446	Shared Neighborhood Hits	135
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

PAK3_MOUSE
θ value	1.38821 (rank : 257)	NC score	0.034264 (rank : 767)
Query Neighborhood Hits	446	Target Neighborhood Hits	874	Shared Neighborhood Hits	53
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

PC11X_HUMAN
θ value	1.38821 (rank : 258)	NC score	0.000862 (rank : 848)
Query Neighborhood Hits	446	Target Neighborhood Hits	199	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BZA7, Q2TJH0, Q2TJH1, Q2TJH3, Q5JVZ0, Q70LR8, Q70LS7, Q70LS8, Q70LS9, Q70LT7, Q70LT8, Q70LT9, Q70LU0, Q70LU1, Q96RV4, Q96RW0, Q9BZA6, Q9H4E0, Q9P2M0, Q9P2X5	Gene names	PCDH11X, PCDH11, PCDHX
Domain Architecture	No domain graphic available
Description	Protocadherin-11 X-linked precursor (Protocadherin-11) (Protocadherin on the X chromosome) (PCDH-X) (Protocadherin-S).

PHC1_HUMAN
θ value	1.38821 (rank : 259)	NC score	0.057517 (rank : 597)
Query Neighborhood Hits	446	Target Neighborhood Hits	227	Shared Neighborhood Hits	38
SwissProt Accessions	P78364, Q8WVM3, Q9BU63	Gene names	PHC1, EDR1, PH1
Domain Architecture
Description	Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1).

PTCD1_HUMAN
θ value	1.38821 (rank : 260)	NC score	0.026771 (rank : 783)
Query Neighborhood Hits	446	Target Neighborhood Hits	52	Shared Neighborhood Hits	7
SwissProt Accessions	O75127, Q66K60, Q9UDV2	Gene names	PTCD1, KIAA0632
Domain Architecture	No domain graphic available
Description	Pentatricopeptide repeat protein 1.

REST_MOUSE
θ value	1.38821 (rank : 261)	NC score	0.017811 (rank : 813)
Query Neighborhood Hits	446	Target Neighborhood Hits	1506	Shared Neighborhood Hits	56
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

RGS3_MOUSE
θ value	1.38821 (rank : 262)	NC score	0.100470 (rank : 304)
Query Neighborhood Hits	446	Target Neighborhood Hits	1621	Shared Neighborhood Hits	180
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

SDCB2_HUMAN
θ value	1.38821 (rank : 263)	NC score	0.172800 (rank : 166)
Query Neighborhood Hits	446	Target Neighborhood Hits	121	Shared Neighborhood Hits	86
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

SEN34_MOUSE
θ value	1.38821 (rank : 264)	NC score	0.030976 (rank : 777)
Query Neighborhood Hits	446	Target Neighborhood Hits	158	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BMZ5, Q58EU2, Q99LV6, Q9CYW1	Gene names	Tsen34, Leng5, Sen34
Domain Architecture	No domain graphic available
Description	tRNA-splicing endonuclease subunit Sen34 (EC 3.1.27.9) (tRNA-intron endonuclease Sen34) (Leukocyte receptor cluster member 5 homolog).

TIAM1_HUMAN
θ value	1.38821 (rank : 265)	NC score	0.159990 (rank : 182)
Query Neighborhood Hits	446	Target Neighborhood Hits	225	Shared Neighborhood Hits	81
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	1.38821 (rank : 266)	NC score	0.149242 (rank : 196)
Query Neighborhood Hits	446	Target Neighborhood Hits	205	Shared Neighborhood Hits	61
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ZO2_HUMAN
θ value	1.38821 (rank : 267)	NC score	0.165666 (rank : 176)
Query Neighborhood Hits	446	Target Neighborhood Hits	289	Shared Neighborhood Hits	118
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ATF4_HUMAN
θ value	1.81305 (rank : 268)	NC score	0.024888 (rank : 788)
Query Neighborhood Hits	446	Target Neighborhood Hits	110	Shared Neighborhood Hits	6
SwissProt Accessions	P18848, Q9UH31	Gene names	ATF4
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-4 (Activating transcription factor 4) (DNA-binding protein TAXREB67) (Cyclic AMP response element-binding protein 2) (CREB2).

BIN1_MOUSE
θ value	1.81305 (rank : 269)	NC score	0.073241 (rank : 463)
Query Neighborhood Hits	446	Target Neighborhood Hits	283	Shared Neighborhood Hits	69
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

CE016_MOUSE
θ value	1.81305 (rank : 270)	NC score	0.026896 (rank : 782)
Query Neighborhood Hits	446	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BRJ3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C5orf16 homolog.

CRK_HUMAN
θ value	1.81305 (rank : 271)	NC score	0.177056 (rank : 157)
Query Neighborhood Hits	446	Target Neighborhood Hits	308	Shared Neighborhood Hits	119
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

ECM1_MOUSE
θ value	1.81305 (rank : 272)	NC score	0.032110 (rank : 775)
Query Neighborhood Hits	446	Target Neighborhood Hits	105	Shared Neighborhood Hits	15
SwissProt Accessions	Q61508	Gene names	Ecm1
Domain Architecture
Description	Extracellular matrix protein 1 precursor (Secretory component p85).

EFS_HUMAN
θ value	1.81305 (rank : 273)	NC score	0.150062 (rank : 194)
Query Neighborhood Hits	446	Target Neighborhood Hits	348	Shared Neighborhood Hits	126
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

GAB1_HUMAN
θ value	1.81305 (rank : 274)	NC score	0.038913 (rank : 758)
Query Neighborhood Hits	446	Target Neighborhood Hits	279	Shared Neighborhood Hits	35
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GRIP1_HUMAN
θ value	1.81305 (rank : 275)	NC score	0.233050 (rank : 80)
Query Neighborhood Hits	446	Target Neighborhood Hits	231	Shared Neighborhood Hits	116
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

IWS1_HUMAN
θ value	1.81305 (rank : 276)	NC score	0.040311 (rank : 752)
Query Neighborhood Hits	446	Target Neighborhood Hits	1241	Shared Neighborhood Hits	80
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

JPH2_HUMAN
θ value	1.81305 (rank : 277)	NC score	0.029401 (rank : 778)
Query Neighborhood Hits	446	Target Neighborhood Hits	639	Shared Neighborhood Hits	55
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

LIPA3_HUMAN
θ value	1.81305 (rank : 278)	NC score	0.058172 (rank : 584)
Query Neighborhood Hits	446	Target Neighborhood Hits	828	Shared Neighborhood Hits	50
SwissProt Accessions	O75145, Q9H8B5, Q9UEW4	Gene names	PPFIA3, KIAA0654
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

LIPA3_MOUSE
θ value	1.81305 (rank : 279)	NC score	0.062992 (rank : 541)
Query Neighborhood Hits	446	Target Neighborhood Hits	636	Shared Neighborhood Hits	45
SwissProt Accessions	P60469	Gene names	Ppfia3
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

MPP4_HUMAN
θ value	1.81305 (rank : 280)	NC score	0.170749 (rank : 170)
Query Neighborhood Hits	446	Target Neighborhood Hits	205	Shared Neighborhood Hits	124
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

NOLC1_HUMAN
θ value	1.81305 (rank : 281)	NC score	0.076152 (rank : 440)
Query Neighborhood Hits	446	Target Neighborhood Hits	452	Shared Neighborhood Hits	59
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

NUCL_MOUSE
θ value	1.81305 (rank : 282)	NC score	0.019527 (rank : 802)
Query Neighborhood Hits	446	Target Neighborhood Hits	425	Shared Neighborhood Hits	20
SwissProt Accessions	P09405, Q548M9, Q61991, Q99K50	Gene names	Ncl, Nuc
Domain Architecture
Description	Nucleolin (Protein C23).

PDLI2_MOUSE
θ value	1.81305 (rank : 283)	NC score	0.177056 (rank : 156)
Query Neighborhood Hits	446	Target Neighborhood Hits	220	Shared Neighborhood Hits	94
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

PER2_HUMAN
θ value	1.81305 (rank : 284)	NC score	0.019143 (rank : 808)
Query Neighborhood Hits	446	Target Neighborhood Hits	170	Shared Neighborhood Hits	24
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

PTN13_HUMAN
θ value	1.81305 (rank : 285)	NC score	0.138113 (rank : 209)
Query Neighborhood Hits	446	Target Neighborhood Hits	471	Shared Neighborhood Hits	122
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

RPB1_MOUSE
θ value	1.81305 (rank : 286)	NC score	0.052142 (rank : 693)
Query Neighborhood Hits	446	Target Neighborhood Hits	363	Shared Neighborhood Hits	52
SwissProt Accessions	P08775	Gene names	Polr2a, Rpii215, Rpo2-1
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

SON_HUMAN
θ value	1.81305 (rank : 287)	NC score	0.072951 (rank : 466)
Query Neighborhood Hits	446	Target Neighborhood Hits	1568	Shared Neighborhood Hits	128
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

ST14_MOUSE
θ value	1.81305 (rank : 288)	NC score	0.000340 (rank : 849)
Query Neighborhood Hits	446	Target Neighborhood Hits	419	Shared Neighborhood Hits	6
SwissProt Accessions	P56677	Gene names	St14, Prss14
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Epithin).

STAM1_HUMAN
θ value	1.81305 (rank : 289)	NC score	0.186861 (rank : 143)
Query Neighborhood Hits	446	Target Neighborhood Hits	271	Shared Neighborhood Hits	117
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	1.81305 (rank : 290)	NC score	0.189246 (rank : 139)
Query Neighborhood Hits	446	Target Neighborhood Hits	273	Shared Neighborhood Hits	121
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ABI2_HUMAN
θ value	2.36792 (rank : 291)	NC score	0.203562 (rank : 116)
Query Neighborhood Hits	446	Target Neighborhood Hits	350	Shared Neighborhood Hits	149
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	2.36792 (rank : 292)	NC score	0.193253 (rank : 135)
Query Neighborhood Hits	446	Target Neighborhood Hits	266	Shared Neighborhood Hits	126
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

CCDC9_MOUSE
θ value	2.36792 (rank : 293)	NC score	0.034092 (rank : 768)
Query Neighborhood Hits	446	Target Neighborhood Hits	196	Shared Neighborhood Hits	24
SwissProt Accessions	Q8VC31	Gene names	Ccdc9
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 9.

ECM2_HUMAN
θ value	2.36792 (rank : 294)	NC score	0.008772 (rank : 839)
Query Neighborhood Hits	446	Target Neighborhood Hits	402	Shared Neighborhood Hits	9
SwissProt Accessions	O94769	Gene names	ECM2
Domain Architecture
Description	Extracellular matrix protein 2 precursor (Matrix glycoprotein SC1/ECM2).

EKI1_HUMAN
θ value	2.36792 (rank : 295)	NC score	0.019018 (rank : 809)
Query Neighborhood Hits	446	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HBU6	Gene names	ETNK1, EKI1
Domain Architecture
Description	Ethanolamine kinase 1 (EC 2.7.1.82) (EKI 1).

LCK_MOUSE
θ value	2.36792 (rank : 296)	NC score	0.084252 (rank : 376)
Query Neighborhood Hits	446	Target Neighborhood Hits	981	Shared Neighborhood Hits	105
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LMBL3_HUMAN
θ value	2.36792 (rank : 297)	NC score	0.040201 (rank : 754)
Query Neighborhood Hits	446	Target Neighborhood Hits	88	Shared Neighborhood Hits	16
SwissProt Accessions	Q96JM7, Q5VUM9, Q6P9B5	Gene names	L3MBTL3, KIAA1798
Domain Architecture	No domain graphic available
Description	Lethal(3)malignant brain tumor-like 3 protein (L(3)mbt-like 3 protein) (H-l(3)mbt-like protein).

LMBL3_MOUSE
θ value	2.36792 (rank : 298)	NC score	0.046651 (rank : 742)
Query Neighborhood Hits	446	Target Neighborhood Hits	212	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BLB7, Q641L7, Q6ZPI2, Q8C0G4	Gene names	L3mbtl3
Domain Architecture	No domain graphic available
Description	Lethal(3)malignant brain tumor-like 3 protein (L(3)mbt-like 3 protein).

MTF1_HUMAN
θ value	2.36792 (rank : 299)	NC score	-0.006843 (rank : 853)
Query Neighborhood Hits	446	Target Neighborhood Hits	814	Shared Neighborhood Hits	23
SwissProt Accessions	Q14872, Q96CB1	Gene names	MTF1
Domain Architecture	No domain graphic available
Description	Metal-regulatory transcription factor 1 (Transcription factor MTF-1) (MRE-binding transcription factor).

MYO1F_MOUSE
θ value	2.36792 (rank : 300)	NC score	0.089590 (rank : 346)
Query Neighborhood Hits	446	Target Neighborhood Hits	262	Shared Neighborhood Hits	104
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

NFH_HUMAN
θ value	2.36792 (rank : 301)	NC score	0.028523 (rank : 779)
Query Neighborhood Hits	446	Target Neighborhood Hits	1242	Shared Neighborhood Hits	89
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

NFIP2_HUMAN
θ value	2.36792 (rank : 302)	NC score	0.035603 (rank : 765)
Query Neighborhood Hits	446	Target Neighborhood Hits	72	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NV92, Q7Z2H3, Q7Z428, Q8TAR3, Q9ULQ5	Gene names	NDFIP2, KIAA1165, N4WBP5A
Domain Architecture	No domain graphic available
Description	NEDD4 family-interacting protein 2 (NEDD4 WW domain-binding protein 5A) (Putative MAPK-activating protein PM04/PM05/PM06/PM07) (Putative NF-kappa-B-activating protein 413).

PDLI2_HUMAN
θ value	2.36792 (rank : 303)	NC score	0.173376 (rank : 165)
Query Neighborhood Hits	446	Target Neighborhood Hits	245	Shared Neighborhood Hits	98
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

PSD4_HUMAN
θ value	2.36792 (rank : 304)	NC score	0.023875 (rank : 792)
Query Neighborhood Hits	446	Target Neighborhood Hits	178	Shared Neighborhood Hits	32
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

SH3G3_HUMAN
θ value	2.36792 (rank : 305)	NC score	0.192185 (rank : 136)
Query Neighborhood Hits	446	Target Neighborhood Hits	222	Shared Neighborhood Hits	99
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SYP2L_MOUSE
θ value	2.36792 (rank : 306)	NC score	0.162234 (rank : 179)
Query Neighborhood Hits	446	Target Neighborhood Hits	289	Shared Neighborhood Hits	111
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

TARA_HUMAN
θ value	2.36792 (rank : 307)	NC score	0.063490 (rank : 535)
Query Neighborhood Hits	446	Target Neighborhood Hits	1626	Shared Neighborhood Hits	127
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TARSH_HUMAN
θ value	2.36792 (rank : 308)	NC score	0.078094 (rank : 427)
Query Neighborhood Hits	446	Target Neighborhood Hits	768	Shared Neighborhood Hits	92
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

ACINU_MOUSE
θ value	3.0926 (rank : 309)	NC score	0.044379 (rank : 746)
Query Neighborhood Hits	446	Target Neighborhood Hits	712	Shared Neighborhood Hits	64
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

BIN1_HUMAN
θ value	3.0926 (rank : 310)	NC score	0.068639 (rank : 499)
Query Neighborhood Hits	446	Target Neighborhood Hits	335	Shared Neighborhood Hits	75
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

CAC1H_HUMAN
θ value	3.0926 (rank : 311)	NC score	0.017775 (rank : 814)
Query Neighborhood Hits	446	Target Neighborhood Hits	307	Shared Neighborhood Hits	33
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

DBNL_HUMAN
θ value	3.0926 (rank : 312)	NC score	0.150299 (rank : 193)
Query Neighborhood Hits	446	Target Neighborhood Hits	244	Shared Neighborhood Hits	91
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	3.0926 (rank : 313)	NC score	0.151027 (rank : 190)
Query Neighborhood Hits	446	Target Neighborhood Hits	306	Shared Neighborhood Hits	100
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DLG5_HUMAN
θ value	3.0926 (rank : 314)	NC score	0.150484 (rank : 192)
Query Neighborhood Hits	446	Target Neighborhood Hits	1088	Shared Neighborhood Hits	168
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

EPHA2_MOUSE
θ value	3.0926 (rank : 315)	NC score	0.076085 (rank : 441)
Query Neighborhood Hits	446	Target Neighborhood Hits	1020	Shared Neighborhood Hits	70
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

FGR_MOUSE
θ value	3.0926 (rank : 316)	NC score	0.100480 (rank : 303)
Query Neighborhood Hits	446	Target Neighborhood Hits	1069	Shared Neighborhood Hits	146
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

K1849_MOUSE
θ value	3.0926 (rank : 317)	NC score	0.178567 (rank : 153)
Query Neighborhood Hits	446	Target Neighborhood Hits	335	Shared Neighborhood Hits	108
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

LIPA2_HUMAN
θ value	3.0926 (rank : 318)	NC score	0.050509 (rank : 724)
Query Neighborhood Hits	446	Target Neighborhood Hits	1044	Shared Neighborhood Hits	48
SwissProt Accessions	O75334	Gene names	PPFIA2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

LIPA2_MOUSE
θ value	3.0926 (rank : 319)	NC score	0.047032 (rank : 741)
Query Neighborhood Hits	446	Target Neighborhood Hits	1282	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BSS9, Q8BN73	Gene names	Ppfia2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

LIPA4_HUMAN
θ value	3.0926 (rank : 320)	NC score	0.079639 (rank : 417)
Query Neighborhood Hits	446	Target Neighborhood Hits	56	Shared Neighborhood Hits	22
SwissProt Accessions	O75335, O94971	Gene names	PPFIA4, KIAA0897
Domain Architecture
Description	Liprin-alpha-4 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4) (PTPRF-interacting protein alpha-4).

MSX1_HUMAN
θ value	3.0926 (rank : 321)	NC score	0.001983 (rank : 846)
Query Neighborhood Hits	446	Target Neighborhood Hits	374	Shared Neighborhood Hits	8
SwissProt Accessions	P28360, Q96NY4	Gene names	MSX1, HOX7
Domain Architecture
Description	Homeobox protein MSX-1 (Msh homeobox 1-like protein) (Hox-7).

MYO1E_HUMAN
θ value	3.0926 (rank : 322)	NC score	0.089022 (rank : 350)
Query Neighborhood Hits	446	Target Neighborhood Hits	293	Shared Neighborhood Hits	107
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

MYO1F_HUMAN
θ value	3.0926 (rank : 323)	NC score	0.089502 (rank : 347)
Query Neighborhood Hits	446	Target Neighborhood Hits	275	Shared Neighborhood Hits	111
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

NBEA_MOUSE
θ value	3.0926 (rank : 324)	NC score	0.018355 (rank : 812)
Query Neighborhood Hits	446	Target Neighborhood Hits	225	Shared Neighborhood Hits	17
SwissProt Accessions	Q9EPN1, Q8C931, Q9EPM9, Q9EPN0, Q9WVM9	Gene names	Nbea, Lyst2
Domain Architecture
Description	Protein neurobeachin (Lysosomal-trafficking regulator 2).

NOXO1_MOUSE
θ value	3.0926 (rank : 325)	NC score	0.151594 (rank : 189)
Query Neighborhood Hits	446	Target Neighborhood Hits	114	Shared Neighborhood Hits	72
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

PCLO_HUMAN
θ value	3.0926 (rank : 326)	NC score	0.069162 (rank : 495)
Query Neighborhood Hits	446	Target Neighborhood Hits	2046	Shared Neighborhood Hits	165
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PGCA_HUMAN
θ value	3.0926 (rank : 327)	NC score	0.019207 (rank : 806)
Query Neighborhood Hits	446	Target Neighborhood Hits	821	Shared Neighborhood Hits	51
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

PHLPP_HUMAN
θ value	3.0926 (rank : 328)	NC score	0.021941 (rank : 797)
Query Neighborhood Hits	446	Target Neighborhood Hits	604	Shared Neighborhood Hits	45
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

RPB1_HUMAN
θ value	3.0926 (rank : 329)	NC score	0.050020 (rank : 738)
Query Neighborhood Hits	446	Target Neighborhood Hits	362	Shared Neighborhood Hits	52
SwissProt Accessions	P24928	Gene names	POLR2A
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

RPC62_MOUSE
θ value	3.0926 (rank : 330)	NC score	0.019227 (rank : 805)
Query Neighborhood Hits	446	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D483, Q8R0I2	Gene names	Polr3c, Rpc62
Domain Architecture
Description	DNA-directed RNA polymerase III 62 kDa polypeptide (EC 2.7.7.6) (RNA polymerase C subunit 3) (RPC3) (RNA polymerase III C62 subunit).

SIA7A_HUMAN
θ value	3.0926 (rank : 331)	NC score	0.025964 (rank : 785)
Query Neighborhood Hits	446	Target Neighborhood Hits	177	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NSC7, Q6UW90, Q9NSC6	Gene names	ST6GALNAC1, SIAT7A
Domain Architecture
Description	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC 2.4.99.3) (GalNAc alpha-2,6-sialyltransferase I) (ST6GalNAc I) (Sialyltransferase 7A).

SRBS1_HUMAN
θ value	3.0926 (rank : 332)	NC score	0.201640 (rank : 119)
Query Neighborhood Hits	446	Target Neighborhood Hits	396	Shared Neighborhood Hits	126
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

TERF2_HUMAN
θ value	3.0926 (rank : 333)	NC score	0.037900 (rank : 761)
Query Neighborhood Hits	446	Target Neighborhood Hits	102	Shared Neighborhood Hits	10
SwissProt Accessions	Q15554	Gene names	TERF2, TRF2
Domain Architecture
Description	Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein).

TSH2_HUMAN
θ value	3.0926 (rank : 334)	NC score	0.009765 (rank : 835)
Query Neighborhood Hits	446	Target Neighborhood Hits	479	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NRE2, Q4VXM4, Q6N003, Q8N260	Gene names	TSHZ2, C20orf17, TSH2, ZNF218
Domain Architecture	No domain graphic available
Description	Teashirt homolog 2 (Zinc finger protein 218) (Ovarian cancer-related protein 10-2) (OVC10-2).

BARH2_MOUSE
θ value	4.03905 (rank : 335)	NC score	0.001408 (rank : 847)
Query Neighborhood Hits	446	Target Neighborhood Hits	397	Shared Neighborhood Hits	16
SwissProt Accessions	Q8VIB5, Q66L43	Gene names	Barhl2, Barh1, Mbh1
Domain Architecture	No domain graphic available
Description	BarH-like 2 homeobox protein (Bar-class homeodomain protein MBH1) (Homeobox protein B-H1).

CDN1C_HUMAN
θ value	4.03905 (rank : 336)	NC score	0.056382 (rank : 618)
Query Neighborhood Hits	446	Target Neighborhood Hits	168	Shared Neighborhood Hits	41
SwissProt Accessions	P49918	Gene names	CDKN1C, KIP2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57KIP2).

CENPC_MOUSE
θ value	4.03905 (rank : 337)	NC score	0.020938 (rank : 800)
Query Neighborhood Hits	446	Target Neighborhood Hits	154	Shared Neighborhood Hits	15
SwissProt Accessions	P49452	Gene names	Cenpc1, Cenpc
Domain Architecture	No domain graphic available
Description	Centromere protein C 1 (CENP-C) (Centromere autoantigen C).

CT055_HUMAN
θ value	4.03905 (rank : 338)	NC score	0.028452 (rank : 780)
Query Neighborhood Hits	446	Target Neighborhood Hits	42	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BQ89	Gene names	C20orf55
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf55.

DGKK_HUMAN
θ value	4.03905 (rank : 339)	NC score	0.099969 (rank : 307)
Query Neighborhood Hits	446	Target Neighborhood Hits	378	Shared Neighborhood Hits	62
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

ERBB3_MOUSE
θ value	4.03905 (rank : 340)	NC score	0.056358 (rank : 620)
Query Neighborhood Hits	446	Target Neighborhood Hits	898	Shared Neighborhood Hits	52
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

K1688_HUMAN
θ value	4.03905 (rank : 341)	NC score	0.031919 (rank : 776)
Query Neighborhood Hits	446	Target Neighborhood Hits	217	Shared Neighborhood Hits	33
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

MAGE1_HUMAN
θ value	4.03905 (rank : 342)	NC score	0.056068 (rank : 623)
Query Neighborhood Hits	446	Target Neighborhood Hits	1389	Shared Neighborhood Hits	124
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MILK1_MOUSE
θ value	4.03905 (rank : 343)	NC score	0.044853 (rank : 744)
Query Neighborhood Hits	446	Target Neighborhood Hits	788	Shared Neighborhood Hits	91
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

NCOA6_MOUSE
θ value	4.03905 (rank : 344)	NC score	0.057548 (rank : 595)
Query Neighborhood Hits	446	Target Neighborhood Hits	1076	Shared Neighborhood Hits	99
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

NFH_MOUSE
θ value	4.03905 (rank : 345)	NC score	0.064626 (rank : 523)
Query Neighborhood Hits	446	Target Neighborhood Hits	2247	Shared Neighborhood Hits	165
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

PAK1_HUMAN
θ value	4.03905 (rank : 346)	NC score	0.033841 (rank : 769)
Query Neighborhood Hits	446	Target Neighborhood Hits	873	Shared Neighborhood Hits	52
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

PAK3_HUMAN
θ value	4.03905 (rank : 347)	NC score	0.033586 (rank : 771)
Query Neighborhood Hits	446	Target Neighborhood Hits	887	Shared Neighborhood Hits	53
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PCOC1_HUMAN
θ value	4.03905 (rank : 348)	NC score	0.012922 (rank : 824)
Query Neighborhood Hits	446	Target Neighborhood Hits	146	Shared Neighborhood Hits	14
SwissProt Accessions	Q15113, O14550	Gene names	PCOLCE, PCPE1
Domain Architecture
Description	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein).

PDLI5_HUMAN
θ value	4.03905 (rank : 349)	NC score	0.108989 (rank : 273)
Query Neighborhood Hits	446	Target Neighborhood Hits	322	Shared Neighborhood Hits	105
SwissProt Accessions	Q96HC4, O60705	Gene names	PDLIM5, ENH
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

RARA_HUMAN
θ value	4.03905 (rank : 350)	NC score	0.005363 (rank : 840)
Query Neighborhood Hits	446	Target Neighborhood Hits	118	Shared Neighborhood Hits	4
SwissProt Accessions	P10276, P78456, Q13440, Q13441, Q9NQS0	Gene names	RARA, NR1B1
Domain Architecture
Description	Retinoic acid receptor alpha (RAR-alpha).

RTN4_HUMAN
θ value	4.03905 (rank : 351)	NC score	0.038243 (rank : 760)
Query Neighborhood Hits	446	Target Neighborhood Hits	357	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NQC3, O94962, Q9BXG5, Q9H212, Q9H3I3, Q9UQ42, Q9Y293, Q9Y2Y7, Q9Y5U6	Gene names	RTN4, KIAA0886, NOGO
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) (Foocen) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5).

SON_MOUSE
θ value	4.03905 (rank : 352)	NC score	0.057935 (rank : 589)
Query Neighborhood Hits	446	Target Neighborhood Hits	957	Shared Neighborhood Hits	81
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

SRBS1_MOUSE
θ value	4.03905 (rank : 353)	NC score	0.207351 (rank : 114)
Query Neighborhood Hits	446	Target Neighborhood Hits	409	Shared Neighborhood Hits	120
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

TNR8_MOUSE
θ value	4.03905 (rank : 354)	NC score	0.016452 (rank : 816)
Query Neighborhood Hits	446	Target Neighborhood Hits	208	Shared Neighborhood Hits	12
SwissProt Accessions	Q60846	Gene names	Tnfrsf8
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 8 precursor (CD30L receptor) (Lymphocyte activation antigen CD30).

UBTD2_HUMAN
θ value	4.03905 (rank : 355)	NC score	0.018362 (rank : 811)
Query Neighborhood Hits	446	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WUN7, Q8TDQ3	Gene names	UBTD2, DCUBP
Domain Architecture	No domain graphic available
Description	Ubiquitin domain-containing protein 2 (Dendritic cell-derived ubiquitin-like protein) (DC-UbP) (Ubiquitin-like protein SB72).

ZO2_MOUSE
θ value	4.03905 (rank : 356)	NC score	0.156494 (rank : 185)
Query Neighborhood Hits	446	Target Neighborhood Hits	296	Shared Neighborhood Hits	120
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

AATK_HUMAN
θ value	5.27518 (rank : 357)	NC score	0.057391 (rank : 601)
Query Neighborhood Hits	446	Target Neighborhood Hits	1243	Shared Neighborhood Hits	101
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

ANM2_HUMAN
θ value	5.27518 (rank : 358)	NC score	0.108119 (rank : 279)
Query Neighborhood Hits	446	Target Neighborhood Hits	175	Shared Neighborhood Hits	91
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

CLR59_HUMAN
θ value	5.27518 (rank : 359)	NC score	0.025445 (rank : 786)
Query Neighborhood Hits	446	Target Neighborhood Hits	163	Shared Neighborhood Hits	15
SwissProt Accessions	Q96DZ5, Q8WWL1, Q96C99, Q9UFT7	Gene names	CLIPR59
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 170-related 59 kDa protein (CLIPR-59) (CLIP-170-related 59 kDa protein).

E2F2_MOUSE
θ value	5.27518 (rank : 360)	NC score	0.013912 (rank : 823)
Query Neighborhood Hits	446	Target Neighborhood Hits	42	Shared Neighborhood Hits	6
SwissProt Accessions	P56931, Q8BID0	Gene names	E2f2
Domain Architecture	No domain graphic available
Description	Transcription factor E2F2 (E2F-2).

GAK12_HUMAN
θ value	5.27518 (rank : 361)	NC score	0.011514 (rank : 829)
Query Neighborhood Hits	446	Target Neighborhood Hits	374	Shared Neighborhood Hits	24
SwissProt Accessions	P63130, Q9UKI0	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q22 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K102 Gag protein) (HERV-K(III) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

JIP1_MOUSE
θ value	5.27518 (rank : 362)	NC score	0.054594 (rank : 648)
Query Neighborhood Hits	446	Target Neighborhood Hits	259	Shared Neighborhood Hits	72
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

LCP2_MOUSE
θ value	5.27518 (rank : 363)	NC score	0.068448 (rank : 501)
Query Neighborhood Hits	446	Target Neighborhood Hits	177	Shared Neighborhood Hits	44
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LNX2_HUMAN
θ value	5.27518 (rank : 364)	NC score	0.209180 (rank : 113)
Query Neighborhood Hits	446	Target Neighborhood Hits	389	Shared Neighborhood Hits	112
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

LNX2_MOUSE
θ value	5.27518 (rank : 365)	NC score	0.205538 (rank : 115)
Query Neighborhood Hits	446	Target Neighborhood Hits	407	Shared Neighborhood Hits	115
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

LRC41_HUMAN
θ value	5.27518 (rank : 366)	NC score	0.015832 (rank : 817)
Query Neighborhood Hits	446	Target Neighborhood Hits	51	Shared Neighborhood Hits	9
SwissProt Accessions	Q15345, Q71RA8, Q9BSM0	Gene names	LRRC41, MUF1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 41 (Protein Muf1).

MINT_MOUSE
θ value	5.27518 (rank : 367)	NC score	0.056486 (rank : 614)
Query Neighborhood Hits	446	Target Neighborhood Hits	1514	Shared Neighborhood Hits	120
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

PAK1_MOUSE
θ value	5.27518 (rank : 368)	NC score	0.033718 (rank : 770)
Query Neighborhood Hits	446	Target Neighborhood Hits	878	Shared Neighborhood Hits	54
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

PDLI4_MOUSE
θ value	5.27518 (rank : 369)	NC score	0.114176 (rank : 257)
Query Neighborhood Hits	446	Target Neighborhood Hits	233	Shared Neighborhood Hits	89
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PDLI5_MOUSE
θ value	5.27518 (rank : 370)	NC score	0.100894 (rank : 302)
Query Neighborhood Hits	446	Target Neighborhood Hits	287	Shared Neighborhood Hits	98
SwissProt Accessions	Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2	Gene names	Pdlim5, Enh
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PDZ11_HUMAN
θ value	5.27518 (rank : 371)	NC score	0.247504 (rank : 54)
Query Neighborhood Hits	446	Target Neighborhood Hits	160	Shared Neighborhood Hits	100
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PRGC1_HUMAN
θ value	5.27518 (rank : 372)	NC score	0.015690 (rank : 820)
Query Neighborhood Hits	446	Target Neighborhood Hits	157	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UBK2, Q9UN32	Gene names	PPARGC1A, LEM6, PGC1, PGC1A, PPARGC1
Domain Architecture
Description	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPAR gamma coactivator 1-alpha) (PPARGC-1-alpha) (PGC-1-alpha) (Ligand effect modulator 6).

PTN13_MOUSE
θ value	5.27518 (rank : 373)	NC score	0.133132 (rank : 221)
Query Neighborhood Hits	446	Target Neighborhood Hits	426	Shared Neighborhood Hits	121
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

RARA_MOUSE
θ value	5.27518 (rank : 374)	NC score	0.004968 (rank : 842)
Query Neighborhood Hits	446	Target Neighborhood Hits	113	Shared Neighborhood Hits	4
SwissProt Accessions	P11416, P22603	Gene names	Rara, Nr1b1
Domain Architecture
Description	Retinoic acid receptor alpha (RAR-alpha).

SASH1_HUMAN
θ value	5.27518 (rank : 375)	NC score	0.086681 (rank : 358)
Query Neighborhood Hits	446	Target Neighborhood Hits	292	Shared Neighborhood Hits	104
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SASH1_MOUSE
θ value	5.27518 (rank : 376)	NC score	0.083634 (rank : 379)
Query Neighborhood Hits	446	Target Neighborhood Hits	263	Shared Neighborhood Hits	95
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SNTB2_HUMAN
θ value	5.27518 (rank : 377)	NC score	0.194040 (rank : 131)
Query Neighborhood Hits	446	Target Neighborhood Hits	180	Shared Neighborhood Hits	104
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

SNTB2_MOUSE
θ value	5.27518 (rank : 378)	NC score	0.193813 (rank : 133)
Query Neighborhood Hits	446	Target Neighborhood Hits	181	Shared Neighborhood Hits	101
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

SNTG2_MOUSE
θ value	5.27518 (rank : 379)	NC score	0.202543 (rank : 117)
Query Neighborhood Hits	446	Target Neighborhood Hits	176	Shared Neighborhood Hits	108
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SRRM2_MOUSE
θ value	5.27518 (rank : 380)	NC score	0.077705 (rank : 429)
Query Neighborhood Hits	446	Target Neighborhood Hits	1470	Shared Neighborhood Hits	153
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

ST14_HUMAN
θ value	5.27518 (rank : 381)	NC score	-0.000677 (rank : 851)
Query Neighborhood Hits	446	Target Neighborhood Hits	409	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y5Y6, Q9BS01, Q9H3S0, Q9HB36, Q9HCA3	Gene names	ST14, PRSS14, SNC19, TADG15
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein).

STAC3_MOUSE
θ value	5.27518 (rank : 382)	NC score	0.183486 (rank : 147)
Query Neighborhood Hits	446	Target Neighborhood Hits	232	Shared Neighborhood Hits	101
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

TGON1_MOUSE
θ value	5.27518 (rank : 383)	NC score	0.027438 (rank : 781)
Query Neighborhood Hits	446	Target Neighborhood Hits	243	Shared Neighborhood Hits	28
SwissProt Accessions	Q62313	Gene names	Tgoln1, Ttgn1
Domain Architecture	No domain graphic available
Description	Trans-Golgi network integral membrane protein 1 precursor (TGN38A).

TRFM_HUMAN
θ value	5.27518 (rank : 384)	NC score	0.009177 (rank : 837)
Query Neighborhood Hits	446	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	P08582, Q9BQE2	Gene names	MFI2, MAP97
Domain Architecture
Description	Melanotransferrin precursor (Melanoma-associated antigen p97) (CD228 antigen).

ZDHC8_MOUSE
θ value	5.27518 (rank : 385)	NC score	0.011740 (rank : 827)
Query Neighborhood Hits	446	Target Neighborhood Hits	243	Shared Neighborhood Hits	27
SwissProt Accessions	Q5Y5T5, Q7TNF7	Gene names	Zdhhc8
Domain Architecture	No domain graphic available
Description	Probable palmitoyltransferase ZDHHC8 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 8) (DHHC-8).

BRD8_HUMAN
θ value	6.88961 (rank : 386)	NC score	0.011014 (rank : 830)
Query Neighborhood Hits	446	Target Neighborhood Hits	292	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H0E9, O43178, Q15355, Q59GN0, Q969M9	Gene names	BRD8, SMAP
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8 (p120) (Skeletal muscle abundant protein) (Thyroid hormone receptor coactivating protein 120kDa) (TrCP120).

CI066_HUMAN
θ value	6.88961 (rank : 387)	NC score	0.019825 (rank : 801)
Query Neighborhood Hits	446	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	Q5T8R8, Q96NB0	Gene names	C9orf66
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf66.

CIC_HUMAN
θ value	6.88961 (rank : 388)	NC score	0.057270 (rank : 602)
Query Neighborhood Hits	446	Target Neighborhood Hits	992	Shared Neighborhood Hits	107
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

CO7A1_HUMAN
θ value	6.88961 (rank : 389)	NC score	0.019450 (rank : 804)
Query Neighborhood Hits	446	Target Neighborhood Hits	807	Shared Neighborhood Hits	70
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

CS007_MOUSE
θ value	6.88961 (rank : 390)	NC score	0.042268 (rank : 751)
Query Neighborhood Hits	446	Target Neighborhood Hits	464	Shared Neighborhood Hits	55
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

DCP1A_HUMAN
θ value	6.88961 (rank : 391)	NC score	0.024577 (rank : 790)
Query Neighborhood Hits	446	Target Neighborhood Hits	228	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NPI6	Gene names	DCP1A, SMIF
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 1A (EC 3.-.-.-) (Transcription factor SMIF) (Smad4-interacting transcriptional co-activator).

DLG4_MOUSE
θ value	6.88961 (rank : 392)	NC score	0.226213 (rank : 92)
Query Neighborhood Hits	446	Target Neighborhood Hits	282	Shared Neighborhood Hits	153
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DMXL2_HUMAN
θ value	6.88961 (rank : 393)	NC score	0.011740 (rank : 826)
Query Neighborhood Hits	446	Target Neighborhood Hits	374	Shared Neighborhood Hits	13
SwissProt Accessions	Q8TDJ6, O94938	Gene names	DMXL2, KIAA0856
Domain Architecture	No domain graphic available
Description	Protein DmX-like 2 (Rabconnectin-3).

DVL2_HUMAN
θ value	6.88961 (rank : 394)	NC score	0.089595 (rank : 345)
Query Neighborhood Hits	446	Target Neighborhood Hits	223	Shared Neighborhood Hits	79
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

EPHA2_HUMAN
θ value	6.88961 (rank : 395)	NC score	0.074881 (rank : 449)
Query Neighborhood Hits	446	Target Neighborhood Hits	1021	Shared Neighborhood Hits	70
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

GAK2_HUMAN
θ value	6.88961 (rank : 396)	NC score	0.010867 (rank : 831)
Query Neighborhood Hits	446	Target Neighborhood Hits	406	Shared Neighborhood Hits	26
SwissProt Accessions	Q7LDI9, Q9UKH5, Q9Y6I1, Q9YNA6, Q9YNB0	Gene names	ERVK6
Domain Architecture	No domain graphic available
Description	HERV-K_7p22.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K(C7) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GNAS1_MOUSE
θ value	6.88961 (rank : 397)	NC score	0.021593 (rank : 798)
Query Neighborhood Hits	446	Target Neighborhood Hits	651	Shared Neighborhood Hits	69
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

GRIN1_HUMAN
θ value	6.88961 (rank : 398)	NC score	0.054829 (rank : 644)
Query Neighborhood Hits	446	Target Neighborhood Hits	681	Shared Neighborhood Hits	72
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

GRIP1_MOUSE
θ value	6.88961 (rank : 399)	NC score	0.226343 (rank : 91)
Query Neighborhood Hits	446	Target Neighborhood Hits	241	Shared Neighborhood Hits	119
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

GRIP2_HUMAN
θ value	6.88961 (rank : 400)	NC score	0.234851 (rank : 73)
Query Neighborhood Hits	446	Target Neighborhood Hits	256	Shared Neighborhood Hits	123
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

LIPA1_HUMAN
θ value	6.88961 (rank : 401)	NC score	0.042818 (rank : 750)
Query Neighborhood Hits	446	Target Neighborhood Hits	1294	Shared Neighborhood Hits	57
SwissProt Accessions	Q13136, Q13135, Q14567, Q8N4I2	Gene names	PPFIA1, LIP1
Domain Architecture
Description	Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) (LAR-interacting protein 1) (LIP.1).

MDC1_MOUSE
θ value	6.88961 (rank : 402)	NC score	0.076557 (rank : 437)
Query Neighborhood Hits	446	Target Neighborhood Hits	998	Shared Neighborhood Hits	104
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MPP4_MOUSE
θ value	6.88961 (rank : 403)	NC score	0.145452 (rank : 203)
Query Neighborhood Hits	446	Target Neighborhood Hits	188	Shared Neighborhood Hits	113
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

NGEF_MOUSE
θ value	6.88961 (rank : 404)	NC score	0.116657 (rank : 251)
Query Neighborhood Hits	446	Target Neighborhood Hits	228	Shared Neighborhood Hits	71
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

RGS3_HUMAN
θ value	6.88961 (rank : 405)	NC score	0.079713 (rank : 416)
Query Neighborhood Hits	446	Target Neighborhood Hits	1375	Shared Neighborhood Hits	147
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

SALL1_MOUSE
θ value	6.88961 (rank : 406)	NC score	-0.006524 (rank : 852)
Query Neighborhood Hits	446	Target Neighborhood Hits	826	Shared Neighborhood Hits	16
SwissProt Accessions	Q9ER74, Q920R5	Gene names	Sall1, Sal3
Domain Architecture
Description	Sal-like protein 1 (Zinc finger protein Spalt-3) (Sal-3) (MSal-3).

SC6A5_MOUSE
θ value	6.88961 (rank : 407)	NC score	0.003221 (rank : 845)
Query Neighborhood Hits	446	Target Neighborhood Hits	135	Shared Neighborhood Hits	21
SwissProt Accessions	Q761V0, Q8CFM5, Q91ZQ2	Gene names	Slc6a5, Glyt2
Domain Architecture	No domain graphic available
Description	Sodium- and chloride-dependent glycine transporter 2 (GlyT2) (GlyT-2) (Solute carrier family 6 member 5).

SCML2_HUMAN
θ value	6.88961 (rank : 408)	NC score	0.015725 (rank : 819)
Query Neighborhood Hits	446	Target Neighborhood Hits	68	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UQR0, Q86U98, Q8IWD0, Q8NDP2, Q9UGC5	Gene names	SCML2
Domain Architecture
Description	Sex comb on midleg-like protein 2.

SDCB1_MOUSE
θ value	6.88961 (rank : 409)	NC score	0.185356 (rank : 145)
Query Neighborhood Hits	446	Target Neighborhood Hits	144	Shared Neighborhood Hits	99
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

STAM2_HUMAN
θ value	6.88961 (rank : 410)	NC score	0.172032 (rank : 167)
Query Neighborhood Hits	446	Target Neighborhood Hits	288	Shared Neighborhood Hits	115
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

SYNPO_HUMAN
θ value	6.88961 (rank : 411)	NC score	0.033192 (rank : 772)
Query Neighborhood Hits	446	Target Neighborhood Hits	281	Shared Neighborhood Hits	44
SwissProt Accessions	Q8N3V7, O15271, Q9UPX1	Gene names	SYNPO, KIAA1029
Domain Architecture	No domain graphic available
Description	Synaptopodin.

TAF4_HUMAN
θ value	6.88961 (rank : 412)	NC score	0.064361 (rank : 525)
Query Neighborhood Hits	446	Target Neighborhood Hits	687	Shared Neighborhood Hits	77
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

TBCD4_HUMAN
θ value	6.88961 (rank : 413)	NC score	0.010136 (rank : 834)
Query Neighborhood Hits	446	Target Neighborhood Hits	357	Shared Neighborhood Hits	16
SwissProt Accessions	O60343, Q5W0B9	Gene names	TBC1D4, KIAA0603
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160).

UBTD2_MOUSE
θ value	6.88961 (rank : 414)	NC score	0.015790 (rank : 818)
Query Neighborhood Hits	446	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PGH0, Q8C5Y1	Gene names	Ubtd2
Domain Architecture	No domain graphic available
Description	Ubiquitin domain-containing protein 2.

WNK4_MOUSE
θ value	6.88961 (rank : 415)	NC score	0.040155 (rank : 755)
Query Neighborhood Hits	446	Target Neighborhood Hits	961	Shared Neighborhood Hits	83
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

ABI1_HUMAN
θ value	8.99809 (rank : 416)	NC score	0.175275 (rank : 161)
Query Neighborhood Hits	446	Target Neighborhood Hits	257	Shared Neighborhood Hits	122
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	8.99809 (rank : 417)	NC score	0.176006 (rank : 158)
Query Neighborhood Hits	446	Target Neighborhood Hits	246	Shared Neighborhood Hits	117
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ANKS6_HUMAN
θ value	8.99809 (rank : 418)	NC score	0.045221 (rank : 743)
Query Neighborhood Hits	446	Target Neighborhood Hits	411	Shared Neighborhood Hits	40
SwissProt Accessions	Q68DC2, Q5VSL0, Q5VSL2, Q5VSL3, Q5VSL4, Q68DB8, Q6P2R2, Q8N9L6, Q96D62	Gene names	ANKS6, ANKRD14, SAMD6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6) (Ankyrin repeat domain-containing protein 14).

ANKS6_MOUSE
θ value	8.99809 (rank : 419)	NC score	0.047811 (rank : 740)
Query Neighborhood Hits	446	Target Neighborhood Hits	435	Shared Neighborhood Hits	48
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

ANM2_MOUSE
θ value	8.99809 (rank : 420)	NC score	0.099978 (rank : 306)
Query Neighborhood Hits	446	Target Neighborhood Hits	175	Shared Neighborhood Hits	87
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

CRKL_HUMAN
θ value	8.99809 (rank : 421)	NC score	0.178055 (rank : 154)
Query Neighborhood Hits	446	Target Neighborhood Hits	313	Shared Neighborhood Hits	117
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	8.99809 (rank : 422)	NC score	0.175928 (rank : 159)
Query Neighborhood Hits	446	Target Neighborhood Hits	307	Shared Neighborhood Hits	114
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

DAB2_HUMAN
θ value	8.99809 (rank : 423)	NC score	0.019204 (rank : 807)
Query Neighborhood Hits	446	Target Neighborhood Hits	197	Shared Neighborhood Hits	30
SwissProt Accessions	P98082, Q13598, Q9BTY0, Q9UK04	Gene names	DAB2, DOC2
Domain Architecture
Description	Disabled homolog 2 (Differentially expressed protein 2) (DOC-2).

EPHA1_MOUSE
θ value	8.99809 (rank : 424)	NC score	0.074725 (rank : 451)
Query Neighborhood Hits	446	Target Neighborhood Hits	958	Shared Neighborhood Hits	68
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPN2_HUMAN
θ value	8.99809 (rank : 425)	NC score	0.017430 (rank : 815)
Query Neighborhood Hits	446	Target Neighborhood Hits	156	Shared Neighborhood Hits	22
SwissProt Accessions	O95208, O95207, Q9H7Z2, Q9UPT7	Gene names	EPN2, KIAA1065
Domain Architecture
Description	Epsin-2 (EPS-15-interacting protein 2).

FUT8_HUMAN
θ value	8.99809 (rank : 426)	NC score	0.052972 (rank : 675)
Query Neighborhood Hits	446	Target Neighborhood Hits	67	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

GAK11_HUMAN
θ value	8.99809 (rank : 427)	NC score	0.010591 (rank : 833)
Query Neighborhood Hits	446	Target Neighborhood Hits	409	Shared Neighborhood Hits	26
SwissProt Accessions	P63145, Q9UKI1	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_22q11.21 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K101 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK4_HUMAN
θ value	8.99809 (rank : 428)	NC score	0.010605 (rank : 832)
Query Neighborhood Hits	446	Target Neighborhood Hits	415	Shared Neighborhood Hits	26
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

K1543_MOUSE
θ value	8.99809 (rank : 429)	NC score	0.061762 (rank : 553)
Query Neighborhood Hits	446	Target Neighborhood Hits	497	Shared Neighborhood Hits	76
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

K1688_MOUSE
θ value	8.99809 (rank : 430)	NC score	0.022228 (rank : 796)
Query Neighborhood Hits	446	Target Neighborhood Hits	188	Shared Neighborhood Hits	27
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

KCNH6_HUMAN
θ value	8.99809 (rank : 431)	NC score	0.011732 (rank : 828)
Query Neighborhood Hits	446	Target Neighborhood Hits	222	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

LAD1_MOUSE
θ value	8.99809 (rank : 432)	NC score	0.040223 (rank : 753)
Query Neighborhood Hits	446	Target Neighborhood Hits	391	Shared Neighborhood Hits	47
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

LPHN3_HUMAN
θ value	8.99809 (rank : 433)	NC score	-0.000024 (rank : 850)
Query Neighborhood Hits	446	Target Neighborhood Hits	139	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HAR2, O94867, Q9NWK5	Gene names	LPHN3, KIAA0768, LEC3
Domain Architecture
Description	Latrophilin-3 precursor (Calcium-independent alpha-latrotoxin receptor 3) (Lectomedin-3).

MUC15_HUMAN
θ value	8.99809 (rank : 434)	NC score	0.023834 (rank : 793)
Query Neighborhood Hits	446	Target Neighborhood Hits	61	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N387, Q6UWS3, Q8IXI8, Q8WW41	Gene names	MUC15
Domain Architecture	No domain graphic available
Description	Mucin-15 precursor.

MYLK_MOUSE
θ value	8.99809 (rank : 435)	NC score	0.039499 (rank : 757)
Query Neighborhood Hits	446	Target Neighborhood Hits	1489	Shared Neighborhood Hits	106
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

MYOM2_HUMAN
θ value	8.99809 (rank : 436)	NC score	0.024895 (rank : 787)
Query Neighborhood Hits	446	Target Neighborhood Hits	341	Shared Neighborhood Hits	20
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

NCOA1_MOUSE
θ value	8.99809 (rank : 437)	NC score	0.011943 (rank : 825)
Query Neighborhood Hits	446	Target Neighborhood Hits	196	Shared Neighborhood Hits	18
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NOG2_MOUSE
θ value	8.99809 (rank : 438)	NC score	0.009170 (rank : 838)
Query Neighborhood Hits	446	Target Neighborhood Hits	71	Shared Neighborhood Hits	7
SwissProt Accessions	Q99LH1, Q8BIF8	Gene names	Gnl2
Domain Architecture	No domain graphic available
Description	Nucleolar GTP-binding protein 2.

NPAS4_MOUSE
θ value	8.99809 (rank : 439)	NC score	0.023394 (rank : 794)
Query Neighborhood Hits	446	Target Neighborhood Hits	245	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

NSD1_MOUSE
θ value	8.99809 (rank : 440)	NC score	0.018740 (rank : 810)
Query Neighborhood Hits	446	Target Neighborhood Hits	472	Shared Neighborhood Hits	43
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

PLCG1_HUMAN
θ value	8.99809 (rank : 441)	NC score	0.145809 (rank : 202)
Query Neighborhood Hits	446	Target Neighborhood Hits	293	Shared Neighborhood Hits	98
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SRRM1_MOUSE
θ value	8.99809 (rank : 442)	NC score	0.079100 (rank : 420)
Query Neighborhood Hits	446	Target Neighborhood Hits	966	Shared Neighborhood Hits	107
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

TBX18_HUMAN
θ value	8.99809 (rank : 443)	NC score	0.005337 (rank : 841)
Query Neighborhood Hits	446	Target Neighborhood Hits	148	Shared Neighborhood Hits	11
SwissProt Accessions	O95935, Q7Z6U4, Q9UJI6	Gene names	TBX18
Domain Architecture
Description	T-box transcription factor TBX18 (T-box protein 18).

TRPV4_HUMAN
θ value	8.99809 (rank : 444)	NC score	0.004220 (rank : 844)
Query Neighborhood Hits	446	Target Neighborhood Hits	150	Shared Neighborhood Hits	8
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

WIRE_HUMAN
θ value	8.99809 (rank : 445)	NC score	0.070425 (rank : 487)
Query Neighborhood Hits	446	Target Neighborhood Hits	329	Shared Neighborhood Hits	65
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

ZDHC6_HUMAN
θ value	8.99809 (rank : 446)	NC score	0.004932 (rank : 843)
Query Neighborhood Hits	446	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H6R6, Q53G45, Q96IV7, Q9H605	Gene names	ZDHHC6, ZNF376
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC6 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 6) (DHHC-6) (Zinc finger protein 376) (Transmembrane protein H4).

AATK_MOUSE
θ value	θ > 10 (rank : 447)	NC score	0.055436 (rank : 631)
Query Neighborhood Hits	446	Target Neighborhood Hits	942	Shared Neighborhood Hits	83
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ABI3_HUMAN
θ value	θ > 10 (rank : 448)	NC score	0.148604 (rank : 197)
Query Neighborhood Hits	446	Target Neighborhood Hits	227	Shared Neighborhood Hits	116
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 449)	NC score	0.147439 (rank : 199)
Query Neighborhood Hits	446	Target Neighborhood Hits	227	Shared Neighborhood Hits	108
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ACK1_HUMAN
θ value	θ > 10 (rank : 450)	NC score	0.068226 (rank : 504)
Query Neighborhood Hits	446	Target Neighborhood Hits	1140	Shared Neighborhood Hits	131
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	θ > 10 (rank : 451)	NC score	0.067090 (rank : 509)
Query Neighborhood Hits	446	Target Neighborhood Hits	1080	Shared Neighborhood Hits	133
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

AFAD_HUMAN
θ value	θ > 10 (rank : 452)	NC score	0.144332 (rank : 204)
Query Neighborhood Hits	446	Target Neighborhood Hits	689	Shared Neighborhood Hits	125
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

ALK_HUMAN
θ value	θ > 10 (rank : 453)	NC score	0.056938 (rank : 608)
Query Neighborhood Hits	446	Target Neighborhood Hits	795	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_MOUSE
θ value	θ > 10 (rank : 454)	NC score	0.057488 (rank : 598)
Query Neighborhood Hits	446	Target Neighborhood Hits	811	Shared Neighborhood Hits	59
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

AMPH_HUMAN
θ value	θ > 10 (rank : 455)	NC score	0.070716 (rank : 482)
Query Neighborhood Hits	446	Target Neighborhood Hits	455	Shared Neighborhood Hits	91
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

AMPH_MOUSE
θ value	θ > 10 (rank : 456)	NC score	0.074181 (rank : 457)
Query Neighborhood Hits	446	Target Neighborhood Hits	291	Shared Neighborhood Hits	72
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

ANKK1_HUMAN
θ value	θ > 10 (rank : 457)	NC score	0.065398 (rank : 516)
Query Neighborhood Hits	446	Target Neighborhood Hits	1075	Shared Neighborhood Hits	66
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

ANKK1_MOUSE
θ value	θ > 10 (rank : 458)	NC score	0.064809 (rank : 521)
Query Neighborhood Hits	446	Target Neighborhood Hits	1072	Shared Neighborhood Hits	66
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

ANPRA_MOUSE
θ value	θ > 10 (rank : 459)	NC score	0.050270 (rank : 729)
Query Neighborhood Hits	446	Target Neighborhood Hits	600	Shared Neighborhood Hits	49
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

APS_HUMAN
θ value	θ > 10 (rank : 460)	NC score	0.057571 (rank : 593)
Query Neighborhood Hits	446	Target Neighborhood Hits	162	Shared Neighborhood Hits	47
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

APXL_HUMAN
θ value	θ > 10 (rank : 461)	NC score	0.122235 (rank : 241)
Query Neighborhood Hits	446	Target Neighborhood Hits	553	Shared Neighborhood Hits	107
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

ARAF_HUMAN
θ value	θ > 10 (rank : 462)	NC score	0.053999 (rank : 654)
Query Neighborhood Hits	446	Target Neighborhood Hits	924	Shared Neighborhood Hits	64
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ARAF_MOUSE
θ value	θ > 10 (rank : 463)	NC score	0.053824 (rank : 659)
Query Neighborhood Hits	446	Target Neighborhood Hits	874	Shared Neighborhood Hits	59
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

ARHG1_HUMAN
θ value	θ > 10 (rank : 464)	NC score	0.110071 (rank : 268)
Query Neighborhood Hits	446	Target Neighborhood Hits	176	Shared Neighborhood Hits	30
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 465)	NC score	0.108495 (rank : 277)
Query Neighborhood Hits	446	Target Neighborhood Hits	266	Shared Neighborhood Hits	40
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_HUMAN
θ value	θ > 10 (rank : 466)	NC score	0.087039 (rank : 355)
Query Neighborhood Hits	446	Target Neighborhood Hits	142	Shared Neighborhood Hits	30
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	θ > 10 (rank : 467)	NC score	0.085351 (rank : 366)
Query Neighborhood Hits	446	Target Neighborhood Hits	120	Shared Neighborhood Hits	30
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG3_HUMAN
θ value	θ > 10 (rank : 468)	NC score	0.107402 (rank : 281)
Query Neighborhood Hits	446	Target Neighborhood Hits	82	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 469)	NC score	0.107631 (rank : 280)
Query Neighborhood Hits	446	Target Neighborhood Hits	85	Shared Neighborhood Hits	25
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG4_HUMAN
θ value	θ > 10 (rank : 470)	NC score	0.170429 (rank : 171)
Query Neighborhood Hits	446	Target Neighborhood Hits	242	Shared Neighborhood Hits	108
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	θ > 10 (rank : 471)	NC score	0.157278 (rank : 183)
Query Neighborhood Hits	446	Target Neighborhood Hits	185	Shared Neighborhood Hits	90
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG8_HUMAN
θ value	θ > 10 (rank : 472)	NC score	0.095127 (rank : 326)
Query Neighborhood Hits	446	Target Neighborhood Hits	85	Shared Neighborhood Hits	25
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 473)	NC score	0.104665 (rank : 292)
Query Neighborhood Hits	446	Target Neighborhood Hits	79	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGA_HUMAN
θ value	θ > 10 (rank : 474)	NC score	0.079782 (rank : 415)
Query Neighborhood Hits	446	Target Neighborhood Hits	187	Shared Neighborhood Hits	30
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 475)	NC score	0.074805 (rank : 450)
Query Neighborhood Hits	446	Target Neighborhood Hits	125	Shared Neighborhood Hits	26
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGF_HUMAN
θ value	θ > 10 (rank : 476)	NC score	0.081550 (rank : 394)
Query Neighborhood Hits	446	Target Neighborhood Hits	214	Shared Neighborhood Hits	55
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGG_HUMAN
θ value	θ > 10 (rank : 477)	NC score	0.095027 (rank : 328)
Query Neighborhood Hits	446	Target Neighborhood Hits	129	Shared Neighborhood Hits	43
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 478)	NC score	0.101003 (rank : 301)
Query Neighborhood Hits	446	Target Neighborhood Hits	152	Shared Neighborhood Hits	51
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ASPP1_HUMAN
θ value	θ > 10 (rank : 479)	NC score	0.106942 (rank : 282)
Query Neighborhood Hits	446	Target Neighborhood Hits	956	Shared Neighborhood Hits	149
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_MOUSE
θ value	θ > 10 (rank : 480)	NC score	0.114585 (rank : 256)
Query Neighborhood Hits	446	Target Neighborhood Hits	1244	Shared Neighborhood Hits	178
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP2_HUMAN
θ value	θ > 10 (rank : 481)	NC score	0.090503 (rank : 343)
Query Neighborhood Hits	446	Target Neighborhood Hits	1156	Shared Neighborhood Hits	160
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

ATN1_HUMAN
θ value	θ > 10 (rank : 482)	NC score	0.053146 (rank : 673)
Query Neighborhood Hits	446	Target Neighborhood Hits	676	Shared Neighborhood Hits	72
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

BAG3_HUMAN
θ value	θ > 10 (rank : 483)	NC score	0.050209 (rank : 733)
Query Neighborhood Hits	446	Target Neighborhood Hits	314	Shared Neighborhood Hits	62
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

BAG3_MOUSE
θ value	θ > 10 (rank : 484)	NC score	0.052396 (rank : 686)
Query Neighborhood Hits	446	Target Neighborhood Hits	513	Shared Neighborhood Hits	75
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

BASP_MOUSE
θ value	θ > 10 (rank : 485)	NC score	0.053565 (rank : 664)
Query Neighborhood Hits	446	Target Neighborhood Hits	260	Shared Neighborhood Hits	42
SwissProt Accessions	Q91XV3	Gene names	Basp1, Nap22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

BAT2_HUMAN
θ value	θ > 10 (rank : 486)	NC score	0.084978 (rank : 369)
Query Neighborhood Hits	446	Target Neighborhood Hits	931	Shared Neighborhood Hits	112
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

BAT2_MOUSE
θ value	θ > 10 (rank : 487)	NC score	0.076445 (rank : 438)
Query Neighborhood Hits	446	Target Neighborhood Hits	947	Shared Neighborhood Hits	115
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

BCAR1_HUMAN
θ value	θ > 10 (rank : 488)	NC score	0.135925 (rank : 211)
Query Neighborhood Hits	446	Target Neighborhood Hits	554	Shared Neighborhood Hits	140
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	θ > 10 (rank : 489)	NC score	0.126817 (rank : 237)
Query Neighborhood Hits	446	Target Neighborhood Hits	438	Shared Neighborhood Hits	136
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BLK_HUMAN
θ value	θ > 10 (rank : 490)	NC score	0.082496 (rank : 388)
Query Neighborhood Hits	446	Target Neighborhood Hits	994	Shared Neighborhood Hits	106
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLK_MOUSE
θ value	θ > 10 (rank : 491)	NC score	0.083254 (rank : 382)
Query Neighborhood Hits	446	Target Neighborhood Hits	992	Shared Neighborhood Hits	109
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BMX_HUMAN
θ value	θ > 10 (rank : 492)	NC score	0.060564 (rank : 562)
Query Neighborhood Hits	446	Target Neighborhood Hits	942	Shared Neighborhood Hits	72
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
θ value	θ > 10 (rank : 493)	NC score	0.061279 (rank : 556)
Query Neighborhood Hits	446	Target Neighborhood Hits	912	Shared Neighborhood Hits	70
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BRAF1_HUMAN
θ value	θ > 10 (rank : 494)	NC score	0.053289 (rank : 669)
Query Neighborhood Hits	446	Target Neighborhood Hits	883	Shared Neighborhood Hits	63
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

BSN_HUMAN
θ value	θ > 10 (rank : 495)	NC score	0.069134 (rank : 497)
Query Neighborhood Hits	446	Target Neighborhood Hits	1537	Shared Neighborhood Hits	144
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

BSN_MOUSE
θ value	θ > 10 (rank : 496)	NC score	0.070672 (rank : 483)
Query Neighborhood Hits	446	Target Neighborhood Hits	2057	Shared Neighborhood Hits	167
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

BTK_HUMAN
θ value	θ > 10 (rank : 497)	NC score	0.086984 (rank : 356)
Query Neighborhood Hits	446	Target Neighborhood Hits	1026	Shared Neighborhood Hits	135
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
θ value	θ > 10 (rank : 498)	NC score	0.085362 (rank : 365)
Query Neighborhood Hits	446	Target Neighborhood Hits	1017	Shared Neighborhood Hits	131
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CASL_HUMAN
θ value	θ > 10 (rank : 499)	NC score	0.106108 (rank : 284)
Query Neighborhood Hits	446	Target Neighborhood Hits	259	Shared Neighborhood Hits	100
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	θ > 10 (rank : 500)	NC score	0.108628 (rank : 275)
Query Neighborhood Hits	446	Target Neighborhood Hits	225	Shared Neighborhood Hits	94
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CJ078_MOUSE
θ value	θ > 10 (rank : 501)	NC score	0.051587 (rank : 705)
Query Neighborhood Hits	446	Target Neighborhood Hits	559	Shared Neighborhood Hits	67
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

CK024_HUMAN
θ value	θ > 10 (rank : 502)	NC score	0.055018 (rank : 641)
Query Neighborhood Hits	446	Target Neighborhood Hits	408	Shared Neighborhood Hits	63
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

CN155_HUMAN
θ value	θ > 10 (rank : 503)	NC score	0.059791 (rank : 568)
Query Neighborhood Hits	446	Target Neighborhood Hits	385	Shared Neighborhood Hits	71
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

CS016_HUMAN
θ value	θ > 10 (rank : 504)	NC score	0.052120 (rank : 695)
Query Neighborhood Hits	446	Target Neighborhood Hits	310	Shared Neighborhood Hits	56
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

CSF1R_HUMAN
θ value	θ > 10 (rank : 505)	NC score	0.051193 (rank : 709)
Query Neighborhood Hits	446	Target Neighborhood Hits	943	Shared Neighborhood Hits	51
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CSF1R_MOUSE
θ value	θ > 10 (rank : 506)	NC score	0.050214 (rank : 732)
Query Neighborhood Hits	446	Target Neighborhood Hits	983	Shared Neighborhood Hits	50
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CSF1_HUMAN
θ value	θ > 10 (rank : 507)	NC score	0.050929 (rank : 715)
Query Neighborhood Hits	446	Target Neighborhood Hits	258	Shared Neighborhood Hits	45
SwissProt Accessions	P09603, Q13130, Q14086, Q14806, Q9UQR8	Gene names	CSF1
Domain Architecture
Description	Macrophage colony-stimulating factor 1 precursor (CSF-1) (MCSF) (M- CSF) (Lanimostim).

CSKP_HUMAN
θ value	θ > 10 (rank : 508)	NC score	0.068580 (rank : 500)
Query Neighborhood Hits	446	Target Neighborhood Hits	1022	Shared Neighborhood Hits	174
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKP_MOUSE
θ value	θ > 10 (rank : 509)	NC score	0.066676 (rank : 511)
Query Neighborhood Hits	446	Target Neighborhood Hits	1027	Shared Neighborhood Hits	177
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

CSK_HUMAN
θ value	θ > 10 (rank : 510)	NC score	0.081649 (rank : 393)
Query Neighborhood Hits	446	Target Neighborhood Hits	1009	Shared Neighborhood Hits	116
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	θ > 10 (rank : 511)	NC score	0.081227 (rank : 400)
Query Neighborhood Hits	446	Target Neighborhood Hits	1009	Shared Neighborhood Hits	116
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CT032_HUMAN
θ value	θ > 10 (rank : 512)	NC score	0.131021 (rank : 228)
Query Neighborhood Hits	446	Target Neighborhood Hits	235	Shared Neighborhood Hits	96
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DAPP1_HUMAN
θ value	θ > 10 (rank : 513)	NC score	0.075002 (rank : 448)
Query Neighborhood Hits	446	Target Neighborhood Hits	227	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 514)	NC score	0.074380 (rank : 455)
Query Neighborhood Hits	446	Target Neighborhood Hits	225	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DDEF1_MOUSE
θ value	θ > 10 (rank : 515)	NC score	0.095385 (rank : 325)
Query Neighborhood Hits	446	Target Neighborhood Hits	592	Shared Neighborhood Hits	131
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_HUMAN
θ value	θ > 10 (rank : 516)	NC score	0.084547 (rank : 372)
Query Neighborhood Hits	446	Target Neighborhood Hits	599	Shared Neighborhood Hits	127
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	θ > 10 (rank : 517)	NC score	0.084308 (rank : 375)
Query Neighborhood Hits	446	Target Neighborhood Hits	625	Shared Neighborhood Hits	127
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDR1_HUMAN
θ value	θ > 10 (rank : 518)	NC score	0.058154 (rank : 585)
Query Neighborhood Hits	446	Target Neighborhood Hits	819	Shared Neighborhood Hits	52
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

DDR1_MOUSE
θ value	θ > 10 (rank : 519)	NC score	0.057623 (rank : 591)
Query Neighborhood Hits	446	Target Neighborhood Hits	818	Shared Neighborhood Hits	52
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR2_HUMAN
θ value	θ > 10 (rank : 520)	NC score	0.057548 (rank : 596)
Query Neighborhood Hits	446	Target Neighborhood Hits	818	Shared Neighborhood Hits	52
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DDR2_MOUSE
θ value	θ > 10 (rank : 521)	NC score	0.057456 (rank : 599)
Query Neighborhood Hits	446	Target Neighborhood Hits	813	Shared Neighborhood Hits	51
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DLG4_HUMAN
θ value	θ > 10 (rank : 522)	NC score	0.223953 (rank : 96)
Query Neighborhood Hits	446	Target Neighborhood Hits	286	Shared Neighborhood Hits	151
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DOCK1_HUMAN
θ value	θ > 10 (rank : 523)	NC score	0.051555 (rank : 706)
Query Neighborhood Hits	446	Target Neighborhood Hits	191	Shared Neighborhood Hits	78
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

DOT1L_HUMAN
θ value	θ > 10 (rank : 524)	NC score	0.053350 (rank : 665)
Query Neighborhood Hits	446	Target Neighborhood Hits	660	Shared Neighborhood Hits	76
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

DUET_HUMAN
θ value	θ > 10 (rank : 525)	NC score	0.058507 (rank : 578)
Query Neighborhood Hits	446	Target Neighborhood Hits	1220	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

DVL1L_HUMAN
θ value	θ > 10 (rank : 526)	NC score	0.080730 (rank : 404)
Query Neighborhood Hits	446	Target Neighborhood Hits	146	Shared Neighborhood Hits	73
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

DVL1_HUMAN
θ value	θ > 10 (rank : 527)	NC score	0.085326 (rank : 367)
Query Neighborhood Hits	446	Target Neighborhood Hits	158	Shared Neighborhood Hits	76
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL1_MOUSE
θ value	θ > 10 (rank : 528)	NC score	0.081265 (rank : 399)
Query Neighborhood Hits	446	Target Neighborhood Hits	146	Shared Neighborhood Hits	72
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL2_MOUSE
θ value	θ > 10 (rank : 529)	NC score	0.081690 (rank : 392)
Query Neighborhood Hits	446	Target Neighborhood Hits	233	Shared Neighborhood Hits	80
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL3_HUMAN
θ value	θ > 10 (rank : 530)	NC score	0.083246 (rank : 383)
Query Neighborhood Hits	446	Target Neighborhood Hits	194	Shared Neighborhood Hits	71
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_MOUSE
θ value	θ > 10 (rank : 531)	NC score	0.083944 (rank : 377)
Query Neighborhood Hits	446	Target Neighborhood Hits	198	Shared Neighborhood Hits	74
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

ECT2_HUMAN
θ value	θ > 10 (rank : 532)	NC score	0.091055 (rank : 341)
Query Neighborhood Hits	446	Target Neighborhood Hits	98	Shared Neighborhood Hits	26
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 533)	NC score	0.094630 (rank : 331)
Query Neighborhood Hits	446	Target Neighborhood Hits	98	Shared Neighborhood Hits	26
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

EGFR_HUMAN
θ value	θ > 10 (rank : 534)	NC score	0.058351 (rank : 579)
Query Neighborhood Hits	446	Target Neighborhood Hits	939	Shared Neighborhood Hits	52
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EGFR_MOUSE
θ value	θ > 10 (rank : 535)	NC score	0.057603 (rank : 592)
Query Neighborhood Hits	446	Target Neighborhood Hits	927	Shared Neighborhood Hits	52
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EM55_HUMAN
θ value	θ > 10 (rank : 536)	NC score	0.134800 (rank : 216)
Query Neighborhood Hits	446	Target Neighborhood Hits	228	Shared Neighborhood Hits	144
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

EM55_MOUSE
θ value	θ > 10 (rank : 537)	NC score	0.128705 (rank : 231)
Query Neighborhood Hits	446	Target Neighborhood Hits	221	Shared Neighborhood Hits	143
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

ENAH_MOUSE
θ value	θ > 10 (rank : 538)	NC score	0.055357 (rank : 632)
Query Neighborhood Hits	446	Target Neighborhood Hits	919	Shared Neighborhood Hits	100
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

EPHA1_HUMAN
θ value	θ > 10 (rank : 539)	NC score	0.073168 (rank : 464)
Query Neighborhood Hits	446	Target Neighborhood Hits	997	Shared Neighborhood Hits	69
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHA3_HUMAN
θ value	θ > 10 (rank : 540)	NC score	0.070487 (rank : 486)
Query Neighborhood Hits	446	Target Neighborhood Hits	1005	Shared Neighborhood Hits	62
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA3_MOUSE
θ value	θ > 10 (rank : 541)	NC score	0.070606 (rank : 484)
Query Neighborhood Hits	446	Target Neighborhood Hits	1009	Shared Neighborhood Hits	62
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHA4_HUMAN
θ value	θ > 10 (rank : 542)	NC score	0.073977 (rank : 459)
Query Neighborhood Hits	446	Target Neighborhood Hits	975	Shared Neighborhood Hits	69
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
θ value	θ > 10 (rank : 543)	NC score	0.074357 (rank : 456)
Query Neighborhood Hits	446	Target Neighborhood Hits	982	Shared Neighborhood Hits	70
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA8_HUMAN
θ value	θ > 10 (rank : 544)	NC score	0.075107 (rank : 447)
Query Neighborhood Hits	446	Target Neighborhood Hits	956	Shared Neighborhood Hits	68
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHA8_MOUSE
θ value	θ > 10 (rank : 545)	NC score	0.075636 (rank : 444)
Query Neighborhood Hits	446	Target Neighborhood Hits	969	Shared Neighborhood Hits	72
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHAA_HUMAN
θ value	θ > 10 (rank : 546)	NC score	0.079374 (rank : 418)
Query Neighborhood Hits	446	Target Neighborhood Hits	960	Shared Neighborhood Hits	71
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHB6_HUMAN
θ value	θ > 10 (rank : 547)	NC score	0.079857 (rank : 412)
Query Neighborhood Hits	446	Target Neighborhood Hits	912	Shared Neighborhood Hits	70
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

EPHB6_MOUSE
θ value	θ > 10 (rank : 548)	NC score	0.081009 (rank : 402)
Query Neighborhood Hits	446	Target Neighborhood Hits	906	Shared Neighborhood Hits	74
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

EPS8_HUMAN
θ value	θ > 10 (rank : 549)	NC score	0.059678 (rank : 569)
Query Neighborhood Hits	446	Target Neighborhood Hits	151	Shared Neighborhood Hits	77
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_MOUSE
θ value	θ > 10 (rank : 550)	NC score	0.054758 (rank : 647)
Query Neighborhood Hits	446	Target Neighborhood Hits	157	Shared Neighborhood Hits	74
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ERBB2_HUMAN
θ value	θ > 10 (rank : 551)	NC score	0.061133 (rank : 557)
Query Neighborhood Hits	446	Target Neighborhood Hits	1073	Shared Neighborhood Hits	68
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB2_MOUSE
θ value	θ > 10 (rank : 552)	NC score	0.058958 (rank : 575)
Query Neighborhood Hits	446	Target Neighborhood Hits	918	Shared Neighborhood Hits	57
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB3_HUMAN
θ value	θ > 10 (rank : 553)	NC score	0.055746 (rank : 626)
Query Neighborhood Hits	446	Target Neighborhood Hits	918	Shared Neighborhood Hits	50
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB4_HUMAN
θ value	θ > 10 (rank : 554)	NC score	0.057166 (rank : 605)
Query Neighborhood Hits	446	Target Neighborhood Hits	910	Shared Neighborhood Hits	54
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

ES8L1_HUMAN
θ value	θ > 10 (rank : 555)	NC score	0.051008 (rank : 712)
Query Neighborhood Hits	446	Target Neighborhood Hits	162	Shared Neighborhood Hits	65
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L2_HUMAN
θ value	θ > 10 (rank : 556)	NC score	0.060724 (rank : 561)
Query Neighborhood Hits	446	Target Neighborhood Hits	193	Shared Neighborhood Hits	74
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_MOUSE
θ value	θ > 10 (rank : 557)	NC score	0.061915 (rank : 550)
Query Neighborhood Hits	446	Target Neighborhood Hits	169	Shared Neighborhood Hits	72
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L3_HUMAN
θ value	θ > 10 (rank : 558)	NC score	0.081510 (rank : 395)
Query Neighborhood Hits	446	Target Neighborhood Hits	206	Shared Neighborhood Hits	85
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L3_MOUSE
θ value	θ > 10 (rank : 559)	NC score	0.081213 (rank : 401)
Query Neighborhood Hits	446	Target Neighborhood Hits	168	Shared Neighborhood Hits	82
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FAK1_HUMAN
θ value	θ > 10 (rank : 560)	NC score	0.055260 (rank : 635)
Query Neighborhood Hits	446	Target Neighborhood Hits	850	Shared Neighborhood Hits	52
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
θ value	θ > 10 (rank : 561)	NC score	0.055296 (rank : 634)
Query Neighborhood Hits	446	Target Neighborhood Hits	850	Shared Neighborhood Hits	52
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK2_HUMAN
θ value	θ > 10 (rank : 562)	NC score	0.057246 (rank : 603)
Query Neighborhood Hits	446	Target Neighborhood Hits	847	Shared Neighborhood Hits	51
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_MOUSE
θ value	θ > 10 (rank : 563)	NC score	0.057164 (rank : 606)
Query Neighborhood Hits	446	Target Neighborhood Hits	851	Shared Neighborhood Hits	52
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FARP1_HUMAN
θ value	θ > 10 (rank : 564)	NC score	0.050012 (rank : 739)
Query Neighborhood Hits	446	Target Neighborhood Hits	241	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FARP2_MOUSE
θ value	θ > 10 (rank : 565)	NC score	0.055051 (rank : 640)
Query Neighborhood Hits	446	Target Neighborhood Hits	209	Shared Neighborhood Hits	39
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FER_HUMAN
θ value	θ > 10 (rank : 566)	NC score	0.063455 (rank : 536)
Query Neighborhood Hits	446	Target Neighborhood Hits	1278	Shared Neighborhood Hits	85
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FES_HUMAN
θ value	θ > 10 (rank : 567)	NC score	0.058346 (rank : 580)
Query Neighborhood Hits	446	Target Neighborhood Hits	978	Shared Neighborhood Hits	66
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_MOUSE
θ value	θ > 10 (rank : 568)	NC score	0.057561 (rank : 594)
Query Neighborhood Hits	446	Target Neighborhood Hits	980	Shared Neighborhood Hits	66
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGD1_HUMAN
θ value	θ > 10 (rank : 569)	NC score	0.071070 (rank : 479)
Query Neighborhood Hits	446	Target Neighborhood Hits	367	Shared Neighborhood Hits	71
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	θ > 10 (rank : 570)	NC score	0.071407 (rank : 475)
Query Neighborhood Hits	446	Target Neighborhood Hits	387	Shared Neighborhood Hits	69
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_HUMAN
θ value	θ > 10 (rank : 571)	NC score	0.063568 (rank : 533)
Query Neighborhood Hits	446	Target Neighborhood Hits	151	Shared Neighborhood Hits	27
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	θ > 10 (rank : 572)	NC score	0.064184 (rank : 528)
Query Neighborhood Hits	446	Target Neighborhood Hits	163	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
θ value	θ > 10 (rank : 573)	NC score	0.064781 (rank : 522)
Query Neighborhood Hits	446	Target Neighborhood Hits	249	Shared Neighborhood Hits	34
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	θ > 10 (rank : 574)	NC score	0.068190 (rank : 505)
Query Neighborhood Hits	446	Target Neighborhood Hits	257	Shared Neighborhood Hits	31
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD4_HUMAN
θ value	θ > 10 (rank : 575)	NC score	0.072523 (rank : 471)
Query Neighborhood Hits	446	Target Neighborhood Hits	219	Shared Neighborhood Hits	32
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	θ > 10 (rank : 576)	NC score	0.072660 (rank : 469)
Query Neighborhood Hits	446	Target Neighborhood Hits	227	Shared Neighborhood Hits	33
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD6_MOUSE
θ value	θ > 10 (rank : 577)	NC score	0.056610 (rank : 613)
Query Neighborhood Hits	446	Target Neighborhood Hits	282	Shared Neighborhood Hits	52
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FLT3_HUMAN
θ value	θ > 10 (rank : 578)	NC score	0.051814 (rank : 701)
Query Neighborhood Hits	446	Target Neighborhood Hits	843	Shared Neighborhood Hits	49
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

FLT3_MOUSE
θ value	θ > 10 (rank : 579)	NC score	0.051970 (rank : 699)
Query Neighborhood Hits	446	Target Neighborhood Hits	847	Shared Neighborhood Hits	50
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

FNBP2_HUMAN
θ value	θ > 10 (rank : 580)	NC score	0.077392 (rank : 433)
Query Neighborhood Hits	446	Target Neighborhood Hits	432	Shared Neighborhood Hits	101
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

GGN_HUMAN
θ value	θ > 10 (rank : 581)	NC score	0.050633 (rank : 719)
Query Neighborhood Hits	446	Target Neighborhood Hits	269	Shared Neighborhood Hits	58
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

GGN_MOUSE
θ value	θ > 10 (rank : 582)	NC score	0.050904 (rank : 716)
Query Neighborhood Hits	446	Target Neighborhood Hits	311	Shared Neighborhood Hits	60
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

GIPC1_HUMAN
θ value	θ > 10 (rank : 583)	NC score	0.062954 (rank : 542)
Query Neighborhood Hits	446	Target Neighborhood Hits	91	Shared Neighborhood Hits	60
SwissProt Accessions	O14908, Q9BTC9	Gene names	GIPC1, C19orf3, GIPC, RGS19IP1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Tax interaction protein 2) (TIP-2).

GIPC1_MOUSE
θ value	θ > 10 (rank : 584)	NC score	0.067434 (rank : 508)
Query Neighborhood Hits	446	Target Neighborhood Hits	92	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Z0G0	Gene names	Gipc1, Gipc, Rgs19ip1, Semcap1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Synectin) (SemaF cytoplasmic domain-associated protein 1) (SEMCAP-1).

GIPC2_HUMAN
θ value	θ > 10 (rank : 585)	NC score	0.053790 (rank : 660)
Query Neighborhood Hits	446	Target Neighborhood Hits	93	Shared Neighborhood Hits	58
SwissProt Accessions	Q8TF65, Q8IYD3, Q9NXS7	Gene names	GIPC2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2.

GNRP_HUMAN
θ value	θ > 10 (rank : 586)	NC score	0.063217 (rank : 539)
Query Neighborhood Hits	446	Target Neighborhood Hits	239	Shared Neighborhood Hits	29
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 587)	NC score	0.067524 (rank : 507)
Query Neighborhood Hits	446	Target Neighborhood Hits	191	Shared Neighborhood Hits	30
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GRAP2_MOUSE
θ value	θ > 10 (rank : 588)	NC score	0.191889 (rank : 138)
Query Neighborhood Hits	446	Target Neighborhood Hits	297	Shared Neighborhood Hits	116
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GSCR1_HUMAN
θ value	θ > 10 (rank : 589)	NC score	0.079785 (rank : 414)
Query Neighborhood Hits	446	Target Neighborhood Hits	674	Shared Neighborhood Hits	92
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

HAPIP_HUMAN
θ value	θ > 10 (rank : 590)	NC score	0.057239 (rank : 604)
Query Neighborhood Hits	446	Target Neighborhood Hits	350	Shared Neighborhood Hits	32
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

HCK_HUMAN
θ value	θ > 10 (rank : 591)	NC score	0.086239 (rank : 359)
Query Neighborhood Hits	446	Target Neighborhood Hits	1035	Shared Neighborhood Hits	128
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

HCK_MOUSE
θ value	θ > 10 (rank : 592)	NC score	0.086204 (rank : 361)
Query Neighborhood Hits	446	Target Neighborhood Hits	1029	Shared Neighborhood Hits	127
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

IASPP_HUMAN
θ value	θ > 10 (rank : 593)	NC score	0.115637 (rank : 254)
Query Neighborhood Hits	446	Target Neighborhood Hits	688	Shared Neighborhood Hits	151
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IASPP_MOUSE
θ value	θ > 10 (rank : 594)	NC score	0.110079 (rank : 267)
Query Neighborhood Hits	446	Target Neighborhood Hits	1024	Shared Neighborhood Hits	169
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IGF1R_HUMAN
θ value	θ > 10 (rank : 595)	NC score	0.052785 (rank : 681)
Query Neighborhood Hits	446	Target Neighborhood Hits	977	Shared Neighborhood Hits	53
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGF1R_MOUSE
θ value	θ > 10 (rank : 596)	NC score	0.053247 (rank : 671)
Query Neighborhood Hits	446	Target Neighborhood Hits	973	Shared Neighborhood Hits	52
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IL16_HUMAN
θ value	θ > 10 (rank : 597)	NC score	0.175004 (rank : 162)
Query Neighborhood Hits	446	Target Neighborhood Hits	207	Shared Neighborhood Hits	97
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

IL16_MOUSE
θ value	θ > 10 (rank : 598)	NC score	0.163972 (rank : 177)
Query Neighborhood Hits	446	Target Neighborhood Hits	189	Shared Neighborhood Hits	89
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

ILK1_HUMAN
θ value	θ > 10 (rank : 599)	NC score	0.069950 (rank : 490)
Query Neighborhood Hits	446	Target Neighborhood Hits	857	Shared Neighborhood Hits	59
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 600)	NC score	0.070365 (rank : 488)
Query Neighborhood Hits	446	Target Neighborhood Hits	848	Shared Neighborhood Hits	58
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 601)	NC score	0.070772 (rank : 481)
Query Neighborhood Hits	446	Target Neighborhood Hits	858	Shared Neighborhood Hits	59
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

INSRR_HUMAN
θ value	θ > 10 (rank : 602)	NC score	0.055784 (rank : 625)
Query Neighborhood Hits	446	Target Neighborhood Hits	950	Shared Neighborhood Hits	53
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSRR_MOUSE
θ value	θ > 10 (rank : 603)	NC score	0.054906 (rank : 642)
Query Neighborhood Hits	446	Target Neighborhood Hits	961	Shared Neighborhood Hits	56
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSR_HUMAN
θ value	θ > 10 (rank : 604)	NC score	0.054902 (rank : 643)
Query Neighborhood Hits	446	Target Neighborhood Hits	963	Shared Neighborhood Hits	52
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

INSR_MOUSE
θ value	θ > 10 (rank : 605)	NC score	0.055169 (rank : 639)
Query Neighborhood Hits	446	Target Neighborhood Hits	968	Shared Neighborhood Hits	55
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

IRAK1_HUMAN
θ value	θ > 10 (rank : 606)	NC score	0.050563 (rank : 722)
Query Neighborhood Hits	446	Target Neighborhood Hits	820	Shared Neighborhood Hits	64
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

IRAK3_HUMAN
θ value	θ > 10 (rank : 607)	NC score	0.061971 (rank : 549)
Query Neighborhood Hits	446	Target Neighborhood Hits	644	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK3_MOUSE
θ value	θ > 10 (rank : 608)	NC score	0.060518 (rank : 563)
Query Neighborhood Hits	446	Target Neighborhood Hits	628	Shared Neighborhood Hits	49
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

ITK_HUMAN
θ value	θ > 10 (rank : 609)	NC score	0.072141 (rank : 473)
Query Neighborhood Hits	446	Target Neighborhood Hits	1016	Shared Neighborhood Hits	115
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
θ value	θ > 10 (rank : 610)	NC score	0.069762 (rank : 491)
Query Neighborhood Hits	446	Target Neighborhood Hits	985	Shared Neighborhood Hits	105
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

JAK1_HUMAN
θ value	θ > 10 (rank : 611)	NC score	0.050050 (rank : 737)
Query Neighborhood Hits	446	Target Neighborhood Hits	858	Shared Neighborhood Hits	50
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

KGUA_HUMAN
θ value	θ > 10 (rank : 612)	NC score	0.052248 (rank : 691)
Query Neighborhood Hits	446	Target Neighborhood Hits	41	Shared Neighborhood Hits	14
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KGUA_MOUSE
θ value	θ > 10 (rank : 613)	NC score	0.052228 (rank : 692)
Query Neighborhood Hits	446	Target Neighborhood Hits	45	Shared Neighborhood Hits	14
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KIT_HUMAN
θ value	θ > 10 (rank : 614)	NC score	0.052412 (rank : 685)
Query Neighborhood Hits	446	Target Neighborhood Hits	953	Shared Neighborhood Hits	51
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KIT_MOUSE
θ value	θ > 10 (rank : 615)	NC score	0.052871 (rank : 677)
Query Neighborhood Hits	446	Target Neighborhood Hits	949	Shared Neighborhood Hits	51
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KSR1_HUMAN
θ value	θ > 10 (rank : 616)	NC score	0.052141 (rank : 694)
Query Neighborhood Hits	446	Target Neighborhood Hits	867	Shared Neighborhood Hits	62
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KSR1_MOUSE
θ value	θ > 10 (rank : 617)	NC score	0.052340 (rank : 688)
Query Neighborhood Hits	446	Target Neighborhood Hits	870	Shared Neighborhood Hits	62
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

KSYK_HUMAN
θ value	θ > 10 (rank : 618)	NC score	0.063563 (rank : 534)
Query Neighborhood Hits	446	Target Neighborhood Hits	901	Shared Neighborhood Hits	71
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 619)	NC score	0.064190 (rank : 527)
Query Neighborhood Hits	446	Target Neighborhood Hits	944	Shared Neighborhood Hits	77
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LAP2_HUMAN
θ value	θ > 10 (rank : 620)	NC score	0.068330 (rank : 503)
Query Neighborhood Hits	446	Target Neighborhood Hits	499	Shared Neighborhood Hits	89
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

LAP2_MOUSE
θ value	θ > 10 (rank : 621)	NC score	0.062895 (rank : 543)
Query Neighborhood Hits	446	Target Neighborhood Hits	482	Shared Neighborhood Hits	83
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

LASP1_HUMAN
θ value	θ > 10 (rank : 622)	NC score	0.131328 (rank : 226)
Query Neighborhood Hits	446	Target Neighborhood Hits	293	Shared Neighborhood Hits	100
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	θ > 10 (rank : 623)	NC score	0.131234 (rank : 227)
Query Neighborhood Hits	446	Target Neighborhood Hits	297	Shared Neighborhood Hits	101
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LBC_HUMAN
θ value	θ > 10 (rank : 624)	NC score	0.092291 (rank : 336)
Query Neighborhood Hits	446	Target Neighborhood Hits	90	Shared Neighborhood Hits	23
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

LCP2_HUMAN
θ value	θ > 10 (rank : 625)	NC score	0.077857 (rank : 428)
Query Neighborhood Hits	446	Target Neighborhood Hits	531	Shared Neighborhood Hits	77
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LDB3_HUMAN
θ value	θ > 10 (rank : 626)	NC score	0.097502 (rank : 318)
Query Neighborhood Hits	446	Target Neighborhood Hits	497	Shared Neighborhood Hits	117
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

LDB3_MOUSE
θ value	θ > 10 (rank : 627)	NC score	0.095968 (rank : 323)
Query Neighborhood Hits	446	Target Neighborhood Hits	510	Shared Neighborhood Hits	126
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

LIMK1_HUMAN
θ value	θ > 10 (rank : 628)	NC score	0.058619 (rank : 576)
Query Neighborhood Hits	446	Target Neighborhood Hits	1005	Shared Neighborhood Hits	103
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
θ value	θ > 10 (rank : 629)	NC score	0.058321 (rank : 581)
Query Neighborhood Hits	446	Target Neighborhood Hits	1008	Shared Neighborhood Hits	103
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

LIMK2_HUMAN
θ value	θ > 10 (rank : 630)	NC score	0.056728 (rank : 611)
Query Neighborhood Hits	446	Target Neighborhood Hits	986	Shared Neighborhood Hits	97
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK2_MOUSE
θ value	θ > 10 (rank : 631)	NC score	0.058172 (rank : 583)
Query Neighborhood Hits	446	Target Neighborhood Hits	998	Shared Neighborhood Hits	97
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LMO7_HUMAN
θ value	θ > 10 (rank : 632)	NC score	0.078731 (rank : 421)
Query Neighborhood Hits	446	Target Neighborhood Hits	507	Shared Neighborhood Hits	71
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

LRRC7_HUMAN
θ value	θ > 10 (rank : 633)	NC score	0.071219 (rank : 477)
Query Neighborhood Hits	446	Target Neighborhood Hits	423	Shared Neighborhood Hits	87
SwissProt Accessions	Q96NW7, Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2	Gene names	LRRC7, KIAA1365, LAP1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

LRRC7_MOUSE
θ value	θ > 10 (rank : 634)	NC score	0.070779 (rank : 480)
Query Neighborhood Hits	446	Target Neighborhood Hits	416	Shared Neighborhood Hits	89
SwissProt Accessions	Q80TE7	Gene names	Lrrc7, Kiaa1365, Lap1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

LRRK1_HUMAN
θ value	θ > 10 (rank : 635)	NC score	0.050461 (rank : 725)
Query Neighborhood Hits	446	Target Neighborhood Hits	1237	Shared Neighborhood Hits	67
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK1_MOUSE
θ value	θ > 10 (rank : 636)	NC score	0.050683 (rank : 718)
Query Neighborhood Hits	446	Target Neighborhood Hits	1267	Shared Neighborhood Hits	66
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LTK_HUMAN
θ value	θ > 10 (rank : 637)	NC score	0.058054 (rank : 587)
Query Neighborhood Hits	446	Target Neighborhood Hits	774	Shared Neighborhood Hits	50
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LTK_MOUSE
θ value	θ > 10 (rank : 638)	NC score	0.059490 (rank : 570)
Query Neighborhood Hits	446	Target Neighborhood Hits	770	Shared Neighborhood Hits	50
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

LYN_HUMAN
θ value	θ > 10 (rank : 639)	NC score	0.084426 (rank : 374)
Query Neighborhood Hits	446	Target Neighborhood Hits	1022	Shared Neighborhood Hits	127
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_MOUSE
θ value	θ > 10 (rank : 640)	NC score	0.083593 (rank : 380)
Query Neighborhood Hits	446	Target Neighborhood Hits	1023	Shared Neighborhood Hits	124
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

M3K12_HUMAN
θ value	θ > 10 (rank : 641)	NC score	0.051651 (rank : 704)
Query Neighborhood Hits	446	Target Neighborhood Hits	940	Shared Neighborhood Hits	62
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	θ > 10 (rank : 642)	NC score	0.051462 (rank : 708)
Query Neighborhood Hits	446	Target Neighborhood Hits	957	Shared Neighborhood Hits	61
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K13_HUMAN
θ value	θ > 10 (rank : 643)	NC score	0.051015 (rank : 711)
Query Neighborhood Hits	446	Target Neighborhood Hits	911	Shared Neighborhood Hits	52
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

M3K7_HUMAN
θ value	θ > 10 (rank : 644)	NC score	0.050171 (rank : 735)
Query Neighborhood Hits	446	Target Neighborhood Hits	892	Shared Neighborhood Hits	52
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_MOUSE
θ value	θ > 10 (rank : 645)	NC score	0.050242 (rank : 730)
Query Neighborhood Hits	446	Target Neighborhood Hits	892	Shared Neighborhood Hits	53
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

MATK_HUMAN
θ value	θ > 10 (rank : 646)	NC score	0.068821 (rank : 498)
Query Neighborhood Hits	446	Target Neighborhood Hits	954	Shared Neighborhood Hits	80
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	θ > 10 (rank : 647)	NC score	0.069504 (rank : 494)
Query Neighborhood Hits	446	Target Neighborhood Hits	952	Shared Neighborhood Hits	85
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MCF2L_MOUSE
θ value	θ > 10 (rank : 648)	NC score	0.088173 (rank : 352)
Query Neighborhood Hits	446	Target Neighborhood Hits	255	Shared Neighborhood Hits	40
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 649)	NC score	0.085523 (rank : 364)
Query Neighborhood Hits	446	Target Neighborhood Hits	166	Shared Neighborhood Hits	30
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MERTK_HUMAN
θ value	θ > 10 (rank : 650)	NC score	0.055315 (rank : 633)
Query Neighborhood Hits	446	Target Neighborhood Hits	988	Shared Neighborhood Hits	58
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MERTK_MOUSE
θ value	θ > 10 (rank : 651)	NC score	0.056371 (rank : 619)
Query Neighborhood Hits	446	Target Neighborhood Hits	974	Shared Neighborhood Hits	55
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MET_HUMAN
θ value	θ > 10 (rank : 652)	NC score	0.054583 (rank : 649)
Query Neighborhood Hits	446	Target Neighborhood Hits	831	Shared Neighborhood Hits	51
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MET_MOUSE
θ value	θ > 10 (rank : 653)	NC score	0.054490 (rank : 650)
Query Neighborhood Hits	446	Target Neighborhood Hits	844	Shared Neighborhood Hits	52
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MLKL_HUMAN
θ value	θ > 10 (rank : 654)	NC score	0.058570 (rank : 577)
Query Neighborhood Hits	446	Target Neighborhood Hits	600	Shared Neighborhood Hits	50
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLKL_MOUSE
θ value	θ > 10 (rank : 655)	NC score	0.056863 (rank : 609)
Query Neighborhood Hits	446	Target Neighborhood Hits	707	Shared Neighborhood Hits	50
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLL2_HUMAN
θ value	θ > 10 (rank : 656)	NC score	0.056786 (rank : 610)
Query Neighborhood Hits	446	Target Neighborhood Hits	1788	Shared Neighborhood Hits	131
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

MLL3_MOUSE
θ value	θ > 10 (rank : 657)	NC score	0.050203 (rank : 734)
Query Neighborhood Hits	446	Target Neighborhood Hits	1399	Shared Neighborhood Hits	93
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

MPP2_HUMAN
θ value	θ > 10 (rank : 658)	NC score	0.096367 (rank : 321)
Query Neighborhood Hits	446	Target Neighborhood Hits	173	Shared Neighborhood Hits	109
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

MPP2_MOUSE
θ value	θ > 10 (rank : 659)	NC score	0.097835 (rank : 316)
Query Neighborhood Hits	446	Target Neighborhood Hits	189	Shared Neighborhood Hits	112
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

MPP3_HUMAN
θ value	θ > 10 (rank : 660)	NC score	0.119255 (rank : 249)
Query Neighborhood Hits	446	Target Neighborhood Hits	171	Shared Neighborhood Hits	102
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

MPP3_MOUSE
θ value	θ > 10 (rank : 661)	NC score	0.122177 (rank : 242)
Query Neighborhood Hits	446	Target Neighborhood Hits	165	Shared Neighborhood Hits	101
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

MPP5_HUMAN
θ value	θ > 10 (rank : 662)	NC score	0.121395 (rank : 244)
Query Neighborhood Hits	446	Target Neighborhood Hits	231	Shared Neighborhood Hits	125
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	θ > 10 (rank : 663)	NC score	0.120684 (rank : 246)
Query Neighborhood Hits	446	Target Neighborhood Hits	226	Shared Neighborhood Hits	124
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

MPP6_HUMAN
θ value	θ > 10 (rank : 664)	NC score	0.102565 (rank : 299)
Query Neighborhood Hits	446	Target Neighborhood Hits	180	Shared Neighborhood Hits	110
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
θ value	θ > 10 (rank : 665)	NC score	0.102951 (rank : 297)
Query Neighborhood Hits	446	Target Neighborhood Hits	187	Shared Neighborhood Hits	113
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

MUC1_MOUSE
θ value	θ > 10 (rank : 666)	NC score	0.053590 (rank : 663)
Query Neighborhood Hits	446	Target Neighborhood Hits	388	Shared Neighborhood Hits	48
SwissProt Accessions	Q02496	Gene names	Muc1, Muc-1
Domain Architecture
Description	Mucin-1 precursor (Polymorphic epithelial mucin) (PEMT) (Episialin).

MUC7_HUMAN
θ value	θ > 10 (rank : 667)	NC score	0.075634 (rank : 445)
Query Neighborhood Hits	446	Target Neighborhood Hits	538	Shared Neighborhood Hits	84
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

MUSK_HUMAN
θ value	θ > 10 (rank : 668)	NC score	0.052362 (rank : 687)
Query Neighborhood Hits	446	Target Neighborhood Hits	1074	Shared Neighborhood Hits	53
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

MUSK_MOUSE
θ value	θ > 10 (rank : 669)	NC score	0.052652 (rank : 682)
Query Neighborhood Hits	446	Target Neighborhood Hits	1057	Shared Neighborhood Hits	51
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

NCF2_HUMAN
θ value	θ > 10 (rank : 670)	NC score	0.198595 (rank : 124)
Query Neighborhood Hits	446	Target Neighborhood Hits	229	Shared Neighborhood Hits	108
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 671)	NC score	0.147084 (rank : 200)
Query Neighborhood Hits	446	Target Neighborhood Hits	161	Shared Neighborhood Hits	83
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 672)	NC score	0.154387 (rank : 187)
Query Neighborhood Hits	446	Target Neighborhood Hits	177	Shared Neighborhood Hits	90
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NEB2_HUMAN
θ value	θ > 10 (rank : 673)	NC score	0.129512 (rank : 230)
Query Neighborhood Hits	446	Target Neighborhood Hits	883	Shared Neighborhood Hits	113
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEB2_MOUSE
θ value	θ > 10 (rank : 674)	NC score	0.128299 (rank : 233)
Query Neighborhood Hits	446	Target Neighborhood Hits	889	Shared Neighborhood Hits	105
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEBL_HUMAN
θ value	θ > 10 (rank : 675)	NC score	0.126088 (rank : 238)
Query Neighborhood Hits	446	Target Neighborhood Hits	457	Shared Neighborhood Hits	99
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NEBU_HUMAN
θ value	θ > 10 (rank : 676)	NC score	0.098135 (rank : 315)
Query Neighborhood Hits	446	Target Neighborhood Hits	420	Shared Neighborhood Hits	99
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

NGEF_HUMAN
θ value	θ > 10 (rank : 677)	NC score	0.108192 (rank : 278)
Query Neighborhood Hits	446	Target Neighborhood Hits	166	Shared Neighborhood Hits	61
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NOS1_HUMAN
θ value	θ > 10 (rank : 678)	NC score	0.090173 (rank : 344)
Query Neighborhood Hits	446	Target Neighborhood Hits	218	Shared Neighborhood Hits	94
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

NOS1_MOUSE
θ value	θ > 10 (rank : 679)	NC score	0.073526 (rank : 461)
Query Neighborhood Hits	446	Target Neighborhood Hits	155	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

NOXO1_HUMAN
θ value	θ > 10 (rank : 680)	NC score	0.115596 (rank : 255)
Query Neighborhood Hits	446	Target Neighborhood Hits	100	Shared Neighborhood Hits	64
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NPHP1_HUMAN
θ value	θ > 10 (rank : 681)	NC score	0.116258 (rank : 252)
Query Neighborhood Hits	446	Target Neighborhood Hits	288	Shared Neighborhood Hits	92
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 682)	NC score	0.124849 (rank : 239)
Query Neighborhood Hits	446	Target Neighborhood Hits	267	Shared Neighborhood Hits	106
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

NTRK1_HUMAN
θ value	θ > 10 (rank : 683)	NC score	0.055953 (rank : 624)
Query Neighborhood Hits	446	Target Neighborhood Hits	1023	Shared Neighborhood Hits	53
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

NTRK2_HUMAN
θ value	θ > 10 (rank : 684)	NC score	0.051885 (rank : 700)
Query Neighborhood Hits	446	Target Neighborhood Hits	1081	Shared Neighborhood Hits	52
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
θ value	θ > 10 (rank : 685)	NC score	0.051746 (rank : 703)
Query Neighborhood Hits	446	Target Neighborhood Hits	1088	Shared Neighborhood Hits	52
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

NTRK3_HUMAN
θ value	θ > 10 (rank : 686)	NC score	0.053604 (rank : 662)
Query Neighborhood Hits	446	Target Neighborhood Hits	1115	Shared Neighborhood Hits	52
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

NU214_HUMAN
θ value	θ > 10 (rank : 687)	NC score	0.066014 (rank : 514)
Query Neighborhood Hits	446	Target Neighborhood Hits	657	Shared Neighborhood Hits	78
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

P55G_HUMAN
θ value	θ > 10 (rank : 688)	NC score	0.051800 (rank : 702)
Query Neighborhood Hits	446	Target Neighborhood Hits	451	Shared Neighborhood Hits	45
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 689)	NC score	0.050367 (rank : 727)
Query Neighborhood Hits	446	Target Neighborhood Hits	401	Shared Neighborhood Hits	43
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85A_HUMAN
θ value	θ > 10 (rank : 690)	NC score	0.061450 (rank : 554)
Query Neighborhood Hits	446	Target Neighborhood Hits	479	Shared Neighborhood Hits	72
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 691)	NC score	0.064622 (rank : 524)
Query Neighborhood Hits	446	Target Neighborhood Hits	435	Shared Neighborhood Hits	79
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 692)	NC score	0.064060 (rank : 531)
Query Neighborhood Hits	446	Target Neighborhood Hits	543	Shared Neighborhood Hits	70
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 693)	NC score	0.061058 (rank : 559)
Query Neighborhood Hits	446	Target Neighborhood Hits	519	Shared Neighborhood Hits	59
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PACN1_HUMAN
θ value	θ > 10 (rank : 694)	NC score	0.135387 (rank : 213)
Query Neighborhood Hits	446	Target Neighborhood Hits	320	Shared Neighborhood Hits	109
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 695)	NC score	0.133402 (rank : 219)
Query Neighborhood Hits	446	Target Neighborhood Hits	283	Shared Neighborhood Hits	106
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 696)	NC score	0.128657 (rank : 232)
Query Neighborhood Hits	446	Target Neighborhood Hits	339	Shared Neighborhood Hits	106
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 697)	NC score	0.131569 (rank : 224)
Query Neighborhood Hits	446	Target Neighborhood Hits	382	Shared Neighborhood Hits	114
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 698)	NC score	0.119463 (rank : 248)
Query Neighborhood Hits	446	Target Neighborhood Hits	385	Shared Neighborhood Hits	105
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 699)	NC score	0.120875 (rank : 245)
Query Neighborhood Hits	446	Target Neighborhood Hits	380	Shared Neighborhood Hits	108
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PAR3L_HUMAN
θ value	θ > 10 (rank : 700)	NC score	0.214593 (rank : 108)
Query Neighborhood Hits	446	Target Neighborhood Hits	297	Shared Neighborhood Hits	98
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

PAR6A_HUMAN
θ value	θ > 10 (rank : 701)	NC score	0.099043 (rank : 311)
Query Neighborhood Hits	446	Target Neighborhood Hits	119	Shared Neighborhood Hits	79
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

PAR6A_MOUSE
θ value	θ > 10 (rank : 702)	NC score	0.098888 (rank : 313)
Query Neighborhood Hits	446	Target Neighborhood Hits	115	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

PAR6B_HUMAN
θ value	θ > 10 (rank : 703)	NC score	0.105050 (rank : 289)
Query Neighborhood Hits	446	Target Neighborhood Hits	126	Shared Neighborhood Hits	79
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6B_MOUSE
θ value	θ > 10 (rank : 704)	NC score	0.105273 (rank : 287)
Query Neighborhood Hits	446	Target Neighborhood Hits	128	Shared Neighborhood Hits	79
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6G_HUMAN
θ value	θ > 10 (rank : 705)	NC score	0.110984 (rank : 263)
Query Neighborhood Hits	446	Target Neighborhood Hits	159	Shared Neighborhood Hits	79
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

PAR6G_MOUSE
θ value	θ > 10 (rank : 706)	NC score	0.105106 (rank : 288)
Query Neighborhood Hits	446	Target Neighborhood Hits	121	Shared Neighborhood Hits	76
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

PCLO_MOUSE
θ value	θ > 10 (rank : 707)	NC score	0.099818 (rank : 310)
Query Neighborhood Hits	446	Target Neighborhood Hits	2275	Shared Neighborhood Hits	216
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PDLI1_HUMAN
θ value	θ > 10 (rank : 708)	NC score	0.104801 (rank : 291)
Query Neighborhood Hits	446	Target Neighborhood Hits	242	Shared Neighborhood Hits	80
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PDLI1_MOUSE
θ value	θ > 10 (rank : 709)	NC score	0.103585 (rank : 295)
Query Neighborhood Hits	446	Target Neighborhood Hits	213	Shared Neighborhood Hits	79
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PDLI3_HUMAN
θ value	θ > 10 (rank : 710)	NC score	0.102895 (rank : 298)
Query Neighborhood Hits	446	Target Neighborhood Hits	199	Shared Neighborhood Hits	81
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PDLI3_MOUSE
θ value	θ > 10 (rank : 711)	NC score	0.097426 (rank : 319)
Query Neighborhood Hits	446	Target Neighborhood Hits	197	Shared Neighborhood Hits	78
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PDLI4_HUMAN
θ value	θ > 10 (rank : 712)	NC score	0.109004 (rank : 272)
Query Neighborhood Hits	446	Target Neighborhood Hits	245	Shared Neighborhood Hits	92
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PDZ11_MOUSE
θ value	θ > 10 (rank : 713)	NC score	0.228697 (rank : 85)
Query Neighborhood Hits	446	Target Neighborhood Hits	154	Shared Neighborhood Hits	95
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZD8_HUMAN
θ value	θ > 10 (rank : 714)	NC score	0.073047 (rank : 465)
Query Neighborhood Hits	446	Target Neighborhood Hits	185	Shared Neighborhood Hits	55
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PDZK4_HUMAN
θ value	θ > 10 (rank : 715)	NC score	0.105975 (rank : 285)
Query Neighborhood Hits	446	Target Neighborhood Hits	165	Shared Neighborhood Hits	75
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PDZK4_MOUSE
θ value	θ > 10 (rank : 716)	NC score	0.106198 (rank : 283)
Query Neighborhood Hits	446	Target Neighborhood Hits	165	Shared Neighborhood Hits	76
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PELP1_MOUSE
θ value	θ > 10 (rank : 717)	NC score	0.050341 (rank : 728)
Query Neighborhood Hits	446	Target Neighborhood Hits	709	Shared Neighborhood Hits	77
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

PEX13_HUMAN
θ value	θ > 10 (rank : 718)	NC score	0.096016 (rank : 322)
Query Neighborhood Hits	446	Target Neighborhood Hits	128	Shared Neighborhood Hits	69
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 719)	NC score	0.095435 (rank : 324)
Query Neighborhood Hits	446	Target Neighborhood Hits	126	Shared Neighborhood Hits	70
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PGFRA_HUMAN
θ value	θ > 10 (rank : 720)	NC score	0.050586 (rank : 721)
Query Neighborhood Hits	446	Target Neighborhood Hits	980	Shared Neighborhood Hits	51
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRA_MOUSE
θ value	θ > 10 (rank : 721)	NC score	0.050959 (rank : 714)
Query Neighborhood Hits	446	Target Neighborhood Hits	975	Shared Neighborhood Hits	51
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRB_HUMAN
θ value	θ > 10 (rank : 722)	NC score	0.052314 (rank : 690)
Query Neighborhood Hits	446	Target Neighborhood Hits	962	Shared Neighborhood Hits	52
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PGFRB_MOUSE
θ value	θ > 10 (rank : 723)	NC score	0.052335 (rank : 689)
Query Neighborhood Hits	446	Target Neighborhood Hits	960	Shared Neighborhood Hits	50
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PICK1_HUMAN
θ value	θ > 10 (rank : 724)	NC score	0.110744 (rank : 264)
Query Neighborhood Hits	446	Target Neighborhood Hits	132	Shared Neighborhood Hits	74
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PICK1_MOUSE
θ value	θ > 10 (rank : 725)	NC score	0.110093 (rank : 266)
Query Neighborhood Hits	446	Target Neighborhood Hits	131	Shared Neighborhood Hits	74
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PKHG1_HUMAN
θ value	θ > 10 (rank : 726)	NC score	0.112438 (rank : 260)
Query Neighborhood Hits	446	Target Neighborhood Hits	174	Shared Neighborhood Hits	33
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PKHG4_HUMAN
θ value	θ > 10 (rank : 727)	NC score	0.056469 (rank : 615)
Query Neighborhood Hits	446	Target Neighborhood Hits	200	Shared Neighborhood Hits	28
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

PLCG1_MOUSE
θ value	θ > 10 (rank : 728)	NC score	0.146481 (rank : 201)
Query Neighborhood Hits	446	Target Neighborhood Hits	314	Shared Neighborhood Hits	101
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PRB3_HUMAN
θ value	θ > 10 (rank : 729)	NC score	0.057653 (rank : 590)
Query Neighborhood Hits	446	Target Neighborhood Hits	318	Shared Neighborhood Hits	54
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

PRB4S_HUMAN
θ value	θ > 10 (rank : 730)	NC score	0.059314 (rank : 572)
Query Neighborhood Hits	446	Target Neighborhood Hits	330	Shared Neighborhood Hits	57
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

PREX1_HUMAN
θ value	θ > 10 (rank : 731)	NC score	0.123201 (rank : 240)
Query Neighborhood Hits	446	Target Neighborhood Hits	177	Shared Neighborhood Hits	58
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PRG4_HUMAN
θ value	θ > 10 (rank : 732)	NC score	0.066592 (rank : 512)
Query Neighborhood Hits	446	Target Neighborhood Hits	764	Shared Neighborhood Hits	94
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PRG4_MOUSE
θ value	θ > 10 (rank : 733)	NC score	0.053882 (rank : 657)
Query Neighborhood Hits	446	Target Neighborhood Hits	624	Shared Neighborhood Hits	77
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PRP1_HUMAN
θ value	θ > 10 (rank : 734)	NC score	0.067953 (rank : 506)
Query Neighborhood Hits	446	Target Neighborhood Hits	385	Shared Neighborhood Hits	67
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

PRP2_MOUSE
θ value	θ > 10 (rank : 735)	NC score	0.064117 (rank : 530)
Query Neighborhood Hits	446	Target Neighborhood Hits	347	Shared Neighborhood Hits	60
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

PTK6_HUMAN
θ value	θ > 10 (rank : 736)	NC score	0.080236 (rank : 410)
Query Neighborhood Hits	446	Target Neighborhood Hits	1020	Shared Neighborhood Hits	126
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

PTK6_MOUSE
θ value	θ > 10 (rank : 737)	NC score	0.081802 (rank : 391)
Query Neighborhood Hits	446	Target Neighborhood Hits	1026	Shared Neighborhood Hits	127
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

PZRN4_HUMAN
θ value	θ > 10 (rank : 738)	NC score	0.163831 (rank : 178)
Query Neighborhood Hits	446	Target Neighborhood Hits	438	Shared Neighborhood Hits	99
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

RAF1_HUMAN
θ value	θ > 10 (rank : 739)	NC score	0.053224 (rank : 672)
Query Neighborhood Hits	446	Target Neighborhood Hits	886	Shared Neighborhood Hits	61
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAF1_MOUSE
θ value	θ > 10 (rank : 740)	NC score	0.053068 (rank : 674)
Query Neighborhood Hits	446	Target Neighborhood Hits	886	Shared Neighborhood Hits	61
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAPH1_HUMAN
θ value	θ > 10 (rank : 741)	NC score	0.071804 (rank : 474)
Query Neighborhood Hits	446	Target Neighborhood Hits	593	Shared Neighborhood Hits	93
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

RASA1_HUMAN
θ value	θ > 10 (rank : 742)	NC score	0.059436 (rank : 571)
Query Neighborhood Hits	446	Target Neighborhood Hits	258	Shared Neighborhood Hits	49
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RET_HUMAN
θ value	θ > 10 (rank : 743)	NC score	0.051508 (rank : 707)
Query Neighborhood Hits	446	Target Neighborhood Hits	873	Shared Neighborhood Hits	50
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RET_MOUSE
θ value	θ > 10 (rank : 744)	NC score	0.052095 (rank : 697)
Query Neighborhood Hits	446	Target Neighborhood Hits	884	Shared Neighborhood Hits	52
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RGNEF_MOUSE
θ value	θ > 10 (rank : 745)	NC score	0.091600 (rank : 338)
Query Neighborhood Hits	446	Target Neighborhood Hits	641	Shared Neighborhood Hits	59
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RGP2_HUMAN
θ value	θ > 10 (rank : 746)	NC score	0.053860 (rank : 658)
Query Neighborhood Hits	446	Target Neighborhood Hits	60	Shared Neighborhood Hits	11
SwissProt Accessions	P47736	Gene names	RAP1GAP, RAP1GA1
Domain Architecture
Description	Rap1 GTPase-activating protein 1 (Rap1GAP).

RHG04_HUMAN
θ value	θ > 10 (rank : 747)	NC score	0.097792 (rank : 317)
Query Neighborhood Hits	446	Target Neighborhood Hits	307	Shared Neighborhood Hits	109
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RHG26_HUMAN
θ value	θ > 10 (rank : 748)	NC score	0.080243 (rank : 409)
Query Neighborhood Hits	446	Target Neighborhood Hits	281	Shared Neighborhood Hits	87
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RHPN2_MOUSE
θ value	θ > 10 (rank : 749)	NC score	0.053971 (rank : 655)
Query Neighborhood Hits	446	Target Neighborhood Hits	60	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BWR8, Q9DBN2	Gene names	Rhpn2
Domain Architecture	No domain graphic available
Description	Rhophilin-2 (GTP-Rho-binding protein 2).

RIMB1_MOUSE
θ value	θ > 10 (rank : 750)	NC score	0.096675 (rank : 320)
Query Neighborhood Hits	446	Target Neighborhood Hits	1376	Shared Neighborhood Hits	144
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMS1_HUMAN
θ value	θ > 10 (rank : 751)	NC score	0.072931 (rank : 467)
Query Neighborhood Hits	446	Target Neighborhood Hits	437	Shared Neighborhood Hits	110
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

RIPK2_HUMAN
θ value	θ > 10 (rank : 752)	NC score	0.053252 (rank : 670)
Query Neighborhood Hits	446	Target Neighborhood Hits	774	Shared Neighborhood Hits	50
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RIPK2_MOUSE
θ value	θ > 10 (rank : 753)	NC score	0.052562 (rank : 684)
Query Neighborhood Hits	446	Target Neighborhood Hits	776	Shared Neighborhood Hits	50
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK3_HUMAN
θ value	θ > 10 (rank : 754)	NC score	0.050434 (rank : 726)
Query Neighborhood Hits	446	Target Neighborhood Hits	828	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

RIPK4_HUMAN
θ value	θ > 10 (rank : 755)	NC score	0.063328 (rank : 538)
Query Neighborhood Hits	446	Target Neighborhood Hits	1094	Shared Neighborhood Hits	67
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

RON_HUMAN
θ value	θ > 10 (rank : 756)	NC score	0.053338 (rank : 666)
Query Neighborhood Hits	446	Target Neighborhood Hits	842	Shared Neighborhood Hits	52
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

RON_MOUSE
θ value	θ > 10 (rank : 757)	NC score	0.054217 (rank : 651)
Query Neighborhood Hits	446	Target Neighborhood Hits	836	Shared Neighborhood Hits	52
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ROR1_HUMAN
θ value	θ > 10 (rank : 758)	NC score	0.055553 (rank : 629)
Query Neighborhood Hits	446	Target Neighborhood Hits	1018	Shared Neighborhood Hits	51
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

ROR1_MOUSE
θ value	θ > 10 (rank : 759)	NC score	0.055181 (rank : 637)
Query Neighborhood Hits	446	Target Neighborhood Hits	1025	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

ROR2_HUMAN
θ value	θ > 10 (rank : 760)	NC score	0.055513 (rank : 630)
Query Neighborhood Hits	446	Target Neighborhood Hits	1014	Shared Neighborhood Hits	52
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

ROR2_MOUSE
θ value	θ > 10 (rank : 761)	NC score	0.055596 (rank : 627)
Query Neighborhood Hits	446	Target Neighborhood Hits	1000	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

ROS_HUMAN
θ value	θ > 10 (rank : 762)	NC score	0.056454 (rank : 617)
Query Neighborhood Hits	446	Target Neighborhood Hits	907	Shared Neighborhood Hits	58
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

RUSC1_HUMAN
θ value	θ > 10 (rank : 763)	NC score	0.073302 (rank : 462)
Query Neighborhood Hits	446	Target Neighborhood Hits	226	Shared Neighborhood Hits	89
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

RUSC1_MOUSE
θ value	θ > 10 (rank : 764)	NC score	0.069582 (rank : 493)
Query Neighborhood Hits	446	Target Neighborhood Hits	206	Shared Neighborhood Hits	87
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

RUSC2_MOUSE
θ value	θ > 10 (rank : 765)	NC score	0.057022 (rank : 607)
Query Neighborhood Hits	446	Target Neighborhood Hits	305	Shared Neighborhood Hits	81
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

RYK_HUMAN
θ value	θ > 10 (rank : 766)	NC score	0.058291 (rank : 582)
Query Neighborhood Hits	446	Target Neighborhood Hits	701	Shared Neighborhood Hits	49
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
θ value	θ > 10 (rank : 767)	NC score	0.058120 (rank : 586)
Query Neighborhood Hits	446	Target Neighborhood Hits	715	Shared Neighborhood Hits	49
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

SDCB1_HUMAN
θ value	θ > 10 (rank : 768)	NC score	0.166845 (rank : 175)
Query Neighborhood Hits	446	Target Neighborhood Hits	150	Shared Neighborhood Hits	103
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

SH21B_HUMAN
θ value	θ > 10 (rank : 769)	NC score	0.050236 (rank : 731)
Query Neighborhood Hits	446	Target Neighborhood Hits	101	Shared Neighborhood Hits	25
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 770)	NC score	0.055572 (rank : 628)
Query Neighborhood Hits	446	Target Neighborhood Hits	101	Shared Neighborhood Hits	27
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SHB_HUMAN
θ value	θ > 10 (rank : 771)	NC score	0.052838 (rank : 679)
Query Neighborhood Hits	446	Target Neighborhood Hits	141	Shared Neighborhood Hits	34
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 772)	NC score	0.054827 (rank : 645)
Query Neighborhood Hits	446	Target Neighborhood Hits	137	Shared Neighborhood Hits	34
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 773)	NC score	0.061876 (rank : 551)
Query Neighborhood Hits	446	Target Neighborhood Hits	170	Shared Neighborhood Hits	50
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 774)	NC score	0.060201 (rank : 565)
Query Neighborhood Hits	446	Target Neighborhood Hits	180	Shared Neighborhood Hits	48
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 775)	NC score	0.056459 (rank : 616)
Query Neighborhood Hits	446	Target Neighborhood Hits	170	Shared Neighborhood Hits	47
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 776)	NC score	0.053295 (rank : 668)
Query Neighborhood Hits	446	Target Neighborhood Hits	144	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_HUMAN
θ value	θ > 10 (rank : 777)	NC score	0.062591 (rank : 545)
Query Neighborhood Hits	446	Target Neighborhood Hits	155	Shared Neighborhood Hits	46
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	θ > 10 (rank : 778)	NC score	0.064911 (rank : 520)
Query Neighborhood Hits	446	Target Neighborhood Hits	151	Shared Neighborhood Hits	45
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHD_HUMAN
θ value	θ > 10 (rank : 779)	NC score	0.056717 (rank : 612)
Query Neighborhood Hits	446	Target Neighborhood Hits	204	Shared Neighborhood Hits	41
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 780)	NC score	0.052815 (rank : 680)
Query Neighborhood Hits	446	Target Neighborhood Hits	137	Shared Neighborhood Hits	37
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 781)	NC score	0.053326 (rank : 667)
Query Neighborhood Hits	446	Target Neighborhood Hits	164	Shared Neighborhood Hits	37
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 782)	NC score	0.062108 (rank : 546)
Query Neighborhood Hits	446	Target Neighborhood Hits	169	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHLB1_HUMAN
θ value	θ > 10 (rank : 783)	NC score	0.077545 (rank : 431)
Query Neighborhood Hits	446	Target Neighborhood Hits	96	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB1_MOUSE
θ value	θ > 10 (rank : 784)	NC score	0.076593 (rank : 436)
Query Neighborhood Hits	446	Target Neighborhood Hits	101	Shared Neighborhood Hits	51
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SHLB2_HUMAN
θ value	θ > 10 (rank : 785)	NC score	0.065353 (rank : 517)
Query Neighborhood Hits	446	Target Neighborhood Hits	86	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	θ > 10 (rank : 786)	NC score	0.065632 (rank : 515)
Query Neighborhood Hits	446	Target Neighborhood Hits	88	Shared Neighborhood Hits	45
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SIPA1_HUMAN
θ value	θ > 10 (rank : 787)	NC score	0.073814 (rank : 460)
Query Neighborhood Hits	446	Target Neighborhood Hits	250	Shared Neighborhood Hits	39
SwissProt Accessions	Q96FS4, O14518, O60484, O60618	Gene names	SIPA1, SPA1
Domain Architecture
Description	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase- activating protein Spa-1) (p130 SPA-1).

SIPA1_MOUSE
θ value	θ > 10 (rank : 788)	NC score	0.063202 (rank : 540)
Query Neighborhood Hits	446	Target Neighborhood Hits	158	Shared Neighborhood Hits	24
SwissProt Accessions	P46062, P70204	Gene names	Sipa1, Spa-1, Spa1
Domain Architecture
Description	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase- activating protein Spa-1).

SLAP1_HUMAN
θ value	θ > 10 (rank : 789)	NC score	0.070555 (rank : 485)
Query Neighborhood Hits	446	Target Neighborhood Hits	113	Shared Neighborhood Hits	29
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 790)	NC score	0.069624 (rank : 492)
Query Neighborhood Hits	446	Target Neighborhood Hits	117	Shared Neighborhood Hits	29
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 791)	NC score	0.074486 (rank : 453)
Query Neighborhood Hits	446	Target Neighborhood Hits	139	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 792)	NC score	0.076198 (rank : 439)
Query Neighborhood Hits	446	Target Neighborhood Hits	136	Shared Neighborhood Hits	35
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SLY_HUMAN
θ value	θ > 10 (rank : 793)	NC score	0.071267 (rank : 476)
Query Neighborhood Hits	446	Target Neighborhood Hits	81	Shared Neighborhood Hits	57
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SLY_MOUSE
θ value	θ > 10 (rank : 794)	NC score	0.072564 (rank : 470)
Query Neighborhood Hits	446	Target Neighborhood Hits	108	Shared Neighborhood Hits	63
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SNTB1_HUMAN
θ value	θ > 10 (rank : 795)	NC score	0.160542 (rank : 180)
Query Neighborhood Hits	446	Target Neighborhood Hits	157	Shared Neighborhood Hits	95
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

SNTB1_MOUSE
θ value	θ > 10 (rank : 796)	NC score	0.160104 (rank : 181)
Query Neighborhood Hits	446	Target Neighborhood Hits	160	Shared Neighborhood Hits	95
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

SNX18_HUMAN
θ value	θ > 10 (rank : 797)	NC score	0.083491 (rank : 381)
Query Neighborhood Hits	446	Target Neighborhood Hits	207	Shared Neighborhood Hits	82
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_MOUSE
θ value	θ > 10 (rank : 798)	NC score	0.085057 (rank : 368)
Query Neighborhood Hits	446	Target Neighborhood Hits	198	Shared Neighborhood Hits	80
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX9_HUMAN
θ value	θ > 10 (rank : 799)	NC score	0.071159 (rank : 478)
Query Neighborhood Hits	446	Target Neighborhood Hits	148	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SNX9_MOUSE
θ value	θ > 10 (rank : 800)	NC score	0.060335 (rank : 564)
Query Neighborhood Hits	446	Target Neighborhood Hits	141	Shared Neighborhood Hits	62
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SPN90_HUMAN
θ value	θ > 10 (rank : 801)	NC score	0.061335 (rank : 555)
Query Neighborhood Hits	446	Target Neighborhood Hits	157	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 802)	NC score	0.052099 (rank : 696)
Query Neighborhood Hits	446	Target Neighborhood Hits	157	Shared Neighborhood Hits	54
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SPTA1_HUMAN
θ value	θ > 10 (rank : 803)	NC score	0.059025 (rank : 573)
Query Neighborhood Hits	446	Target Neighborhood Hits	748	Shared Neighborhood Hits	102
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA1_MOUSE
θ value	θ > 10 (rank : 804)	NC score	0.064177 (rank : 529)
Query Neighborhood Hits	446	Target Neighborhood Hits	675	Shared Neighborhood Hits	95
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
θ value	θ > 10 (rank : 805)	NC score	0.075534 (rank : 446)
Query Neighborhood Hits	446	Target Neighborhood Hits	888	Shared Neighborhood Hits	119
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SRC_MOUSE
θ value	θ > 10 (rank : 806)	NC score	0.091257 (rank : 340)
Query Neighborhood Hits	446	Target Neighborhood Hits	1033	Shared Neighborhood Hits	127
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SRGP1_HUMAN
θ value	θ > 10 (rank : 807)	NC score	0.075838 (rank : 443)
Query Neighborhood Hits	446	Target Neighborhood Hits	390	Shared Neighborhood Hits	101
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
θ value	θ > 10 (rank : 808)	NC score	0.077603 (rank : 430)
Query Neighborhood Hits	446	Target Neighborhood Hits	331	Shared Neighborhood Hits	101
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
θ value	θ > 10 (rank : 809)	NC score	0.078549 (rank : 423)
Query Neighborhood Hits	446	Target Neighborhood Hits	324	Shared Neighborhood Hits	102
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRMS_HUMAN
θ value	θ > 10 (rank : 810)	NC score	0.068424 (rank : 502)
Query Neighborhood Hits	446	Target Neighborhood Hits	946	Shared Neighborhood Hits	82
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SRMS_MOUSE
θ value	θ > 10 (rank : 811)	NC score	0.069159 (rank : 496)
Query Neighborhood Hits	446	Target Neighborhood Hits	964	Shared Neighborhood Hits	90
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

SRRM1_HUMAN
θ value	θ > 10 (rank : 812)	NC score	0.070024 (rank : 489)
Query Neighborhood Hits	446	Target Neighborhood Hits	690	Shared Neighborhood Hits	96
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

SRRM2_HUMAN
θ value	θ > 10 (rank : 813)	NC score	0.080222 (rank : 411)
Query Neighborhood Hits	446	Target Neighborhood Hits	1296	Shared Neighborhood Hits	142
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

STAC3_HUMAN
θ value	θ > 10 (rank : 814)	NC score	0.177450 (rank : 155)
Query Neighborhood Hits	446	Target Neighborhood Hits	228	Shared Neighborhood Hits	100
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAM2_MOUSE
θ value	θ > 10 (rank : 815)	NC score	0.171613 (rank : 168)
Query Neighborhood Hits	446	Target Neighborhood Hits	285	Shared Neighborhood Hits	112
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STS1_HUMAN
θ value	θ > 10 (rank : 816)	NC score	0.050145 (rank : 736)
Query Neighborhood Hits	446	Target Neighborhood Hits	106	Shared Neighborhood Hits	54
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
θ value	θ > 10 (rank : 817)	NC score	0.050963 (rank : 713)
Query Neighborhood Hits	446	Target Neighborhood Hits	104	Shared Neighborhood Hits	54
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS2_HUMAN
θ value	θ > 10 (rank : 818)	NC score	0.060177 (rank : 566)
Query Neighborhood Hits	446	Target Neighborhood Hits	108	Shared Neighborhood Hits	55
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

STXB4_HUMAN
θ value	θ > 10 (rank : 819)	NC score	0.098944 (rank : 312)
Query Neighborhood Hits	446	Target Neighborhood Hits	616	Shared Neighborhood Hits	78
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_MOUSE
θ value	θ > 10 (rank : 820)	NC score	0.099952 (rank : 309)
Query Neighborhood Hits	446	Target Neighborhood Hits	629	Shared Neighborhood Hits	79
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STYK1_HUMAN
θ value	θ > 10 (rank : 821)	NC score	0.052059 (rank : 698)
Query Neighborhood Hits	446	Target Neighborhood Hits	786	Shared Neighborhood Hits	49
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

STYK1_MOUSE
θ value	θ > 10 (rank : 822)	NC score	0.055222 (rank : 636)
Query Neighborhood Hits	446	Target Neighborhood Hits	779	Shared Neighborhood Hits	51
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

SYJ2B_HUMAN
θ value	θ > 10 (rank : 823)	NC score	0.234509 (rank : 74)
Query Neighborhood Hits	446	Target Neighborhood Hits	162	Shared Neighborhood Hits	98
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

SYNP2_HUMAN
θ value	θ > 10 (rank : 824)	NC score	0.109533 (rank : 270)
Query Neighborhood Hits	446	Target Neighborhood Hits	323	Shared Neighborhood Hits	96
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

SYNP2_MOUSE
θ value	θ > 10 (rank : 825)	NC score	0.127423 (rank : 235)
Query Neighborhood Hits	446	Target Neighborhood Hits	252	Shared Neighborhood Hits	108
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

TCOF_MOUSE
θ value	θ > 10 (rank : 826)	NC score	0.058045 (rank : 588)
Query Neighborhood Hits	446	Target Neighborhood Hits	471	Shared Neighborhood Hits	60
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

TEC_HUMAN
θ value	θ > 10 (rank : 827)	NC score	0.079239 (rank : 419)
Query Neighborhood Hits	446	Target Neighborhood Hits	1006	Shared Neighborhood Hits	122
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEC_MOUSE
θ value	θ > 10 (rank : 828)	NC score	0.075962 (rank : 442)
Query Neighborhood Hits	446	Target Neighborhood Hits	1006	Shared Neighborhood Hits	122
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEX14_HUMAN
θ value	θ > 10 (rank : 829)	NC score	0.076644 (rank : 435)
Query Neighborhood Hits	446	Target Neighborhood Hits	1103	Shared Neighborhood Hits	87
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
θ value	θ > 10 (rank : 830)	NC score	0.072163 (rank : 472)
Query Neighborhood Hits	446	Target Neighborhood Hits	1333	Shared Neighborhood Hits	90
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TIE2_HUMAN
θ value	θ > 10 (rank : 831)	NC score	0.050746 (rank : 717)
Query Neighborhood Hits	446	Target Neighborhood Hits	1192	Shared Neighborhood Hits	59
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE2_MOUSE
θ value	θ > 10 (rank : 832)	NC score	0.050551 (rank : 723)
Query Neighborhood Hits	446	Target Neighborhood Hits	1204	Shared Neighborhood Hits	56
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

TNI3K_HUMAN
θ value	θ > 10 (rank : 833)	NC score	0.062753 (rank : 544)
Query Neighborhood Hits	446	Target Neighborhood Hits	1084	Shared Neighborhood Hits	66
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNI3K_MOUSE
θ value	θ > 10 (rank : 834)	NC score	0.063449 (rank : 537)
Query Neighborhood Hits	446	Target Neighborhood Hits	1079	Shared Neighborhood Hits	66
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNK1_HUMAN
θ value	θ > 10 (rank : 835)	NC score	0.059900 (rank : 567)
Query Neighborhood Hits	446	Target Neighborhood Hits	815	Shared Neighborhood Hits	60
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TNK1_MOUSE
θ value	θ > 10 (rank : 836)	NC score	0.060863 (rank : 560)
Query Neighborhood Hits	446	Target Neighborhood Hits	806	Shared Neighborhood Hits	61
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

TRIO_HUMAN
θ value	θ > 10 (rank : 837)	NC score	0.058994 (rank : 574)
Query Neighborhood Hits	446	Target Neighborhood Hits	1580	Shared Neighborhood Hits	129
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

TXK_HUMAN
θ value	θ > 10 (rank : 838)	NC score	0.077478 (rank : 432)
Query Neighborhood Hits	446	Target Neighborhood Hits	971	Shared Neighborhood Hits	107
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TXK_MOUSE
θ value	θ > 10 (rank : 839)	NC score	0.078436 (rank : 424)
Query Neighborhood Hits	446	Target Neighborhood Hits	980	Shared Neighborhood Hits	114
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

TYRO3_HUMAN
θ value	θ > 10 (rank : 840)	NC score	0.052948 (rank : 676)
Query Neighborhood Hits	446	Target Neighborhood Hits	995	Shared Neighborhood Hits	53
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

TYRO3_MOUSE
θ value	θ > 10 (rank : 841)	NC score	0.054165 (rank : 653)
Query Neighborhood Hits	446	Target Neighborhood Hits	1007	Shared Neighborhood Hits	55
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

UFO_HUMAN
θ value	θ > 10 (rank : 842)	NC score	0.053891 (rank : 656)
Query Neighborhood Hits	446	Target Neighborhood Hits	981	Shared Neighborhood Hits	56
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

UFO_MOUSE
θ value	θ > 10 (rank : 843)	NC score	0.052840 (rank : 678)
Query Neighborhood Hits	446	Target Neighborhood Hits	988	Shared Neighborhood Hits	55
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

WASIP_HUMAN
θ value	θ > 10 (rank : 844)	NC score	0.074434 (rank : 454)
Query Neighborhood Hits	446	Target Neighborhood Hits	458	Shared Neighborhood Hits	79
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

WASIP_MOUSE
θ value	θ > 10 (rank : 845)	NC score	0.066922 (rank : 510)
Query Neighborhood Hits	446	Target Neighborhood Hits	392	Shared Neighborhood Hits	70
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

WIRE_MOUSE
θ value	θ > 10 (rank : 846)	NC score	0.072909 (rank : 468)
Query Neighborhood Hits	446	Target Neighborhood Hits	310	Shared Neighborhood Hits	62
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

WNK2_HUMAN
θ value	θ > 10 (rank : 847)	NC score	0.054187 (rank : 652)
Query Neighborhood Hits	446	Target Neighborhood Hits	1407	Shared Neighborhood Hits	138
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

ZAP70_HUMAN
θ value	θ > 10 (rank : 848)	NC score	0.065090 (rank : 519)
Query Neighborhood Hits	446	Target Neighborhood Hits	893	Shared Neighborhood Hits	73
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	θ > 10 (rank : 849)	NC score	0.065127 (rank : 518)
Query Neighborhood Hits	446	Target Neighborhood Hits	905	Shared Neighborhood Hits	72
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZO1_HUMAN
θ value	θ > 10 (rank : 850)	NC score	0.149561 (rank : 195)
Query Neighborhood Hits	446	Target Neighborhood Hits	474	Shared Neighborhood Hits	150
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZO1_MOUSE
θ value	θ > 10 (rank : 851)	NC score	0.155779 (rank : 186)
Query Neighborhood Hits	446	Target Neighborhood Hits	453	Shared Neighborhood Hits	154
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZO3_HUMAN
θ value	θ > 10 (rank : 852)	NC score	0.168922 (rank : 174)
Query Neighborhood Hits	446	Target Neighborhood Hits	219	Shared Neighborhood Hits	117
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

ZO3_MOUSE
θ value	θ > 10 (rank : 853)	NC score	0.169199 (rank : 172)
Query Neighborhood Hits	446	Target Neighborhood Hits	224	Shared Neighborhood Hits	113
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

Hits sorted by NC score

SHAN2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	446	Target Neighborhood Hits	446	Shared Neighborhood Hits	446
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SHAN2_HUMAN
NC score	0.910335 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	446	Target Neighborhood Hits	346	Shared Neighborhood Hits	223
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

SHAN1_HUMAN
NC score	0.505642 (rank : 3)	θ value	1.17455e-116 (rank : 3)
Query Neighborhood Hits	446	Target Neighborhood Hits	1041	Shared Neighborhood Hits	305
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

NHERF_HUMAN
NC score	0.415913 (rank : 4)	θ value	9.92553e-07 (rank : 7)
Query Neighborhood Hits	446	Target Neighborhood Hits	190	Shared Neighborhood Hits	119
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHERF_MOUSE
NC score	0.415336 (rank : 5)	θ value	1.29631e-06 (rank : 8)
Query Neighborhood Hits	446	Target Neighborhood Hits	195	Shared Neighborhood Hits	119
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

PDZD1_HUMAN
NC score	0.408980 (rank : 6)	θ value	3.41135e-07 (rank : 6)
Query Neighborhood Hits	446	Target Neighborhood Hits	190	Shared Neighborhood Hits	119
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PDZD1_MOUSE
NC score	0.398591 (rank : 7)	θ value	1.87187e-05 (rank : 14)
Query Neighborhood Hits	446	Target Neighborhood Hits	191	Shared Neighborhood Hits	116
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

NHRF2_HUMAN
NC score	0.393998 (rank : 8)	θ value	0.00020696 (rank : 27)
Query Neighborhood Hits	446	Target Neighborhood Hits	197	Shared Neighborhood Hits	119
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

NHRF2_MOUSE
NC score	0.384219 (rank : 9)	θ value	0.000602161 (rank : 38)
Query Neighborhood Hits	446	Target Neighborhood Hits	194	Shared Neighborhood Hits	118
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

PDZD3_MOUSE
NC score	0.382597 (rank : 10)	θ value	0.000158464 (rank : 25)
Query Neighborhood Hits	446	Target Neighborhood Hits	171	Shared Neighborhood Hits	115
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

GRASP_HUMAN
NC score	0.378479 (rank : 11)	θ value	7.1131e-05 (rank : 20)
Query Neighborhood Hits	446	Target Neighborhood Hits	147	Shared Neighborhood Hits	98
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

PDZD3_HUMAN
NC score	0.375656 (rank : 12)	θ value	0.000270298 (rank : 33)
Query Neighborhood Hits	446	Target Neighborhood Hits	180	Shared Neighborhood Hits	119
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

GRASP_MOUSE
NC score	0.372971 (rank : 13)	θ value	0.000158464 (rank : 22)
Query Neighborhood Hits	446	Target Neighborhood Hits	131	Shared Neighborhood Hits	95
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

PSCBP_MOUSE
NC score	0.356978 (rank : 14)	θ value	0.00134147 (rank : 54)
Query Neighborhood Hits	446	Target Neighborhood Hits	118	Shared Neighborhood Hits	97
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

PSCBP_HUMAN
NC score	0.353845 (rank : 15)	θ value	0.000270298 (rank : 34)
Query Neighborhood Hits	446	Target Neighborhood Hits	123	Shared Neighborhood Hits	94
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

WHRN_HUMAN
NC score	0.321981 (rank : 16)	θ value	0.00228821 (rank : 61)
Query Neighborhood Hits	446	Target Neighborhood Hits	325	Shared Neighborhood Hits	135
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

WHRN_MOUSE
NC score	0.321419 (rank : 17)	θ value	0.00228821 (rank : 62)
Query Neighborhood Hits	446	Target Neighborhood Hits	412	Shared Neighborhood Hits	140
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

PDZD7_HUMAN
NC score	0.321107 (rank : 18)	θ value	0.0431538 (rank : 111)
Query Neighborhood Hits	446	Target Neighborhood Hits	181	Shared Neighborhood Hits	114
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

MAGI1_HUMAN
NC score	0.314176 (rank : 19)	θ value	9.29e-05 (rank : 21)
Query Neighborhood Hits	446	Target Neighborhood Hits	388	Shared Neighborhood Hits	134
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

USH1C_HUMAN
NC score	0.308157 (rank : 20)	θ value	0.0736092 (rank : 140)
Query Neighborhood Hits	446	Target Neighborhood Hits	327	Shared Neighborhood Hits	128
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

MAGI2_HUMAN
NC score	0.306888 (rank : 21)	θ value	0.000270298 (rank : 32)
Query Neighborhood Hits	446	Target Neighborhood Hits	373	Shared Neighborhood Hits	136
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MAGI1_MOUSE
NC score	0.306251 (rank : 22)	θ value	0.00134147 (rank : 51)
Query Neighborhood Hits	446	Target Neighborhood Hits	403	Shared Neighborhood Hits	132
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MAGI2_MOUSE
NC score	0.303447 (rank : 23)	θ value	0.000158464 (rank : 23)
Query Neighborhood Hits	446	Target Neighborhood Hits	370	Shared Neighborhood Hits	135
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

ARHGC_HUMAN
NC score	0.302814 (rank : 24)	θ value	6.43352e-06 (rank : 11)
Query Neighborhood Hits	446	Target Neighborhood Hits	351	Shared Neighborhood Hits	134
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
NC score	0.302406 (rank : 25)	θ value	2.88788e-06 (rank : 9)
Query Neighborhood Hits	446	Target Neighborhood Hits	344	Shared Neighborhood Hits	134
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGB_HUMAN
NC score	0.302165 (rank : 26)	θ value	3.19293e-05 (rank : 16)
Query Neighborhood Hits	446	Target Neighborhood Hits	375	Shared Neighborhood Hits	143
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

USH1C_MOUSE
NC score	0.300019 (rank : 27)	θ value	0.0736092 (rank : 141)
Query Neighborhood Hits	446	Target Neighborhood Hits	557	Shared Neighborhood Hits	144
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

LIN7B_HUMAN
NC score	0.294881 (rank : 28)	θ value	0.0330416 (rank : 107)
Query Neighborhood Hits	446	Target Neighborhood Hits	200	Shared Neighborhood Hits	115
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

LIN7A_MOUSE
NC score	0.293936 (rank : 29)	θ value	0.0736092 (rank : 132)
Query Neighborhood Hits	446	Target Neighborhood Hits	193	Shared Neighborhood Hits	117
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

LIN7B_MOUSE
NC score	0.293284 (rank : 30)	θ value	0.0330416 (rank : 108)
Query Neighborhood Hits	446	Target Neighborhood Hits	200	Shared Neighborhood Hits	115
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

GOPC_MOUSE
NC score	0.292957 (rank : 31)	θ value	0.00134147 (rank : 49)
Query Neighborhood Hits	446	Target Neighborhood Hits	323	Shared Neighborhood Hits	110
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

LIN7A_HUMAN
NC score	0.291959 (rank : 32)	θ value	0.0736092 (rank : 131)
Query Neighborhood Hits	446	Target Neighborhood Hits	193	Shared Neighborhood Hits	117
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

TX1B3_MOUSE
NC score	0.291343 (rank : 33)	θ value	0.21417 (rank : 181)
Query Neighborhood Hits	446	Target Neighborhood Hits	158	Shared Neighborhood Hits	105
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

TX1B3_HUMAN
NC score	0.291319 (rank : 34)	θ value	0.21417 (rank : 180)
Query Neighborhood Hits	446	Target Neighborhood Hits	161	Shared Neighborhood Hits	105
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

GOPC_HUMAN
NC score	0.290819 (rank : 35)	θ value	0.00134147 (rank : 48)
Query Neighborhood Hits	446	Target Neighborhood Hits	377	Shared Neighborhood Hits	116
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

SAM14_HUMAN
NC score	0.289840 (rank : 36)	θ value	3.77169e-06 (rank : 10)
Query Neighborhood Hits	446	Target Neighborhood Hits	81	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IZD0, Q8N2X0	Gene names	SAMD14
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 14.

SH3K1_HUMAN
NC score	0.288990 (rank : 37)	θ value	5.44631e-05 (rank : 19)
Query Neighborhood Hits	446	Target Neighborhood Hits	341	Shared Neighborhood Hits	128
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

LIN7C_HUMAN
NC score	0.287563 (rank : 38)	θ value	0.0961366 (rank : 144)
Query Neighborhood Hits	446	Target Neighborhood Hits	198	Shared Neighborhood Hits	115
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
NC score	0.287563 (rank : 39)	θ value	0.0961366 (rank : 145)
Query Neighborhood Hits	446	Target Neighborhood Hits	198	Shared Neighborhood Hits	115
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

SH3K1_MOUSE
NC score	0.280473 (rank : 40)	θ value	0.00175202 (rank : 58)
Query Neighborhood Hits	446	Target Neighborhood Hits	332	Shared Neighborhood Hits	130
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

INADL_MOUSE
NC score	0.274730 (rank : 41)	θ value	0.0193708 (rank : 98)
Query Neighborhood Hits	446	Target Neighborhood Hits	290	Shared Neighborhood Hits	122
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

INADL_HUMAN
NC score	0.272964 (rank : 42)	θ value	0.0330416 (rank : 106)
Query Neighborhood Hits	446	Target Neighborhood Hits	260	Shared Neighborhood Hits	118
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

ARHG6_HUMAN
NC score	0.268327 (rank : 43)	θ value	5.44631e-05 (rank : 18)
Query Neighborhood Hits	446	Target Neighborhood Hits	376	Shared Neighborhood Hits	113
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG7_HUMAN
NC score	0.268206 (rank : 44)	θ value	1.87187e-05 (rank : 13)
Query Neighborhood Hits	446	Target Neighborhood Hits	347	Shared Neighborhood Hits	122
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG6_MOUSE
NC score	0.267338 (rank : 45)	θ value	4.1701e-05 (rank : 17)
Query Neighborhood Hits	446	Target Neighborhood Hits	394	Shared Neighborhood Hits	115
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

MPDZ_MOUSE
NC score	0.267205 (rank : 46)	θ value	0.21417 (rank : 174)
Query Neighborhood Hits	446	Target Neighborhood Hits	298	Shared Neighborhood Hits	124
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

MPDZ_HUMAN
NC score	0.266389 (rank : 47)	θ value	0.21417 (rank : 173)
Query Neighborhood Hits	446	Target Neighborhood Hits	261	Shared Neighborhood Hits	124
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

PDZD2_HUMAN
NC score	0.265826 (rank : 48)	θ value	0.00509761 (rank : 78)
Query Neighborhood Hits	446	Target Neighborhood Hits	772	Shared Neighborhood Hits	169
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

ARHG7_MOUSE
NC score	0.265041 (rank : 49)	θ value	3.19293e-05 (rank : 15)
Query Neighborhood Hits	446	Target Neighborhood Hits	396	Shared Neighborhood Hits	120
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

CD2AP_MOUSE
NC score	0.264108 (rank : 50)	θ value	0.0148317 (rank : 88)
Query Neighborhood Hits	446	Target Neighborhood Hits	336	Shared Neighborhood Hits	134
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CD2AP_HUMAN
NC score	0.260107 (rank : 51)	θ value	0.0563607 (rank : 116)
Query Neighborhood Hits	446	Target Neighborhood Hits	315	Shared Neighborhood Hits	126
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SAM14_MOUSE
NC score	0.254824 (rank : 52)	θ value	0.00020696 (rank : 28)
Query Neighborhood Hits	446	Target Neighborhood Hits	91	Shared Neighborhood Hits	38
SwissProt Accessions	Q8K070, Q5SWB7, Q8BHE2, Q8C8N5	Gene names	Samd14
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 14.

RHPN1_MOUSE
NC score	0.252087 (rank : 53)	θ value	0.000270298 (rank : 35)
Query Neighborhood Hits	446	Target Neighborhood Hits	154	Shared Neighborhood Hits	98
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

PDZ11_HUMAN
NC score	0.247504 (rank : 54)	θ value	5.27518 (rank : 371)
Query Neighborhood Hits	446	Target Neighborhood Hits	160	Shared Neighborhood Hits	100
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

VAV_MOUSE
NC score	0.244952 (rank : 55)	θ value	0.000158464 (rank : 26)
Query Neighborhood Hits	446	Target Neighborhood Hits	430	Shared Neighborhood Hits	116
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

DGKD_HUMAN
NC score	0.242552 (rank : 56)	θ value	2.28291e-11 (rank : 4)
Query Neighborhood Hits	446	Target Neighborhood Hits	231	Shared Neighborhood Hits	59
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

VAV_HUMAN
NC score	0.241822 (rank : 57)	θ value	0.000602161 (rank : 41)
Query Neighborhood Hits	446	Target Neighborhood Hits	452	Shared Neighborhood Hits	115
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

PARD3_HUMAN
NC score	0.240219 (rank : 58)	θ value	0.365318 (rank : 195)
Query Neighborhood Hits	446	Target Neighborhood Hits	312	Shared Neighborhood Hits	110
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

LNX1_HUMAN
NC score	0.239567 (rank : 59)	θ value	0.00298849 (rank : 67)
Query Neighborhood Hits	446	Target Neighborhood Hits	379	Shared Neighborhood Hits	102
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

NCK1_HUMAN
NC score	0.239458 (rank : 60)	θ value	0.00298849 (rank : 68)
Query Neighborhood Hits	446	Target Neighborhood Hits	312	Shared Neighborhood Hits	119
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

VAV2_HUMAN
NC score	0.239210 (rank : 61)	θ value	0.000786445 (rank : 45)
Query Neighborhood Hits	446	Target Neighborhood Hits	453	Shared Neighborhood Hits	112
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

NCK2_HUMAN
NC score	0.238912 (rank : 62)	θ value	0.00175202 (rank : 56)
Query Neighborhood Hits	446	Target Neighborhood Hits	310	Shared Neighborhood Hits	112
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

STAC_MOUSE
NC score	0.238631 (rank : 63)	θ value	0.000461057 (rank : 36)
Query Neighborhood Hits	446	Target Neighborhood Hits	268	Shared Neighborhood Hits	115
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SNTG1_MOUSE
NC score	0.237602 (rank : 64)	θ value	0.163984 (rank : 166)
Query Neighborhood Hits	446	Target Neighborhood Hits	179	Shared Neighborhood Hits	109
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

PARD3_MOUSE
NC score	0.237484 (rank : 65)	θ value	1.06291 (rank : 241)
Query Neighborhood Hits	446	Target Neighborhood Hits	290	Shared Neighborhood Hits	108
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

DLG3_MOUSE
NC score	0.237322 (rank : 66)	θ value	0.0252991 (rank : 103)
Query Neighborhood Hits	446	Target Neighborhood Hits	274	Shared Neighborhood Hits	150
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

SNTG1_HUMAN
NC score	0.237055 (rank : 67)	θ value	0.21417 (rank : 178)
Query Neighborhood Hits	446	Target Neighborhood Hits	181	Shared Neighborhood Hits	109
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

DLG3_HUMAN
NC score	0.236596 (rank : 68)	θ value	0.0252991 (rank : 102)
Query Neighborhood Hits	446	Target Neighborhood Hits	269	Shared Neighborhood Hits	148
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

VAV3_HUMAN
NC score	0.235999 (rank : 69)	θ value	0.00509761 (rank : 80)
Query Neighborhood Hits	446	Target Neighborhood Hits	398	Shared Neighborhood Hits	115
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV2_MOUSE
NC score	0.235891 (rank : 70)	θ value	0.000602161 (rank : 40)
Query Neighborhood Hits	446	Target Neighborhood Hits	456	Shared Neighborhood Hits	112
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

DLG2_HUMAN
NC score	0.235686 (rank : 71)	θ value	0.0148317 (rank : 89)
Query Neighborhood Hits	446	Target Neighborhood Hits	279	Shared Neighborhood Hits	153
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

VAV3_MOUSE
NC score	0.235014 (rank : 72)	θ value	0.00298849 (rank : 69)
Query Neighborhood Hits	446	Target Neighborhood Hits	404	Shared Neighborhood Hits	116
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

GRIP2_HUMAN
NC score	0.234851 (rank : 73)	θ value	6.88961 (rank : 400)
Query Neighborhood Hits	446	Target Neighborhood Hits	256	Shared Neighborhood Hits	123
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

SYJ2B_HUMAN
NC score	0.234509 (rank : 74)	θ value	θ > 10 (rank : 823)
Query Neighborhood Hits	446	Target Neighborhood Hits	162	Shared Neighborhood Hits	98
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

LNX1_MOUSE
NC score	0.234492 (rank : 75)	θ value	0.0193708 (rank : 100)
Query Neighborhood Hits	446	Target Neighborhood Hits	377	Shared Neighborhood Hits	106
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

APBA3_HUMAN
NC score	0.234012 (rank : 76)	θ value	0.0736092 (rank : 127)
Query Neighborhood Hits	446	Target Neighborhood Hits	201	Shared Neighborhood Hits	110
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

DLG1_HUMAN
NC score	0.233615 (rank : 77)	θ value	0.0563607 (rank : 119)
Query Neighborhood Hits	446	Target Neighborhood Hits	290	Shared Neighborhood Hits	152
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

STAC_HUMAN
NC score	0.233115 (rank : 78)	θ value	0.00665767 (rank : 83)
Query Neighborhood Hits	446	Target Neighborhood Hits	276	Shared Neighborhood Hits	110
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

DLG2_MOUSE
NC score	0.233062 (rank : 79)	θ value	0.00298849 (rank : 63)
Query Neighborhood Hits	446	Target Neighborhood Hits	271	Shared Neighborhood Hits	149
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

GRIP1_HUMAN
NC score	0.233050 (rank : 80)	θ value	1.81305 (rank : 275)
Query Neighborhood Hits	446	Target Neighborhood Hits	231	Shared Neighborhood Hits	116
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

DGKH_HUMAN
NC score	0.232467 (rank : 81)	θ value	1.47974e-10 (rank : 5)
Query Neighborhood Hits	446	Target Neighborhood Hits	255	Shared Neighborhood Hits	64
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

DLG1_MOUSE
NC score	0.229772 (rank : 82)	θ value	0.0736092 (rank : 130)
Query Neighborhood Hits	446	Target Neighborhood Hits	285	Shared Neighborhood Hits	147
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

GRB2_HUMAN
NC score	0.228967 (rank : 83)	θ value	0.00228821 (rank : 59)
Query Neighborhood Hits	446	Target Neighborhood Hits	310	Shared Neighborhood Hits	118
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.228942 (rank : 84)	θ value	0.00228821 (rank : 60)
Query Neighborhood Hits	446	Target Neighborhood Hits	312	Shared Neighborhood Hits	118
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

PDZ11_MOUSE
NC score	0.228697 (rank : 85)	θ value	θ > 10 (rank : 713)
Query Neighborhood Hits	446	Target Neighborhood Hits	154	Shared Neighborhood Hits	95
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

NCF1_HUMAN
NC score	0.228516 (rank : 86)	θ value	0.0330416 (rank : 109)
Query Neighborhood Hits	446	Target Neighborhood Hits	198	Shared Neighborhood Hits	102
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

DNMBP_HUMAN
NC score	0.227913 (rank : 87)	θ value	0.00298849 (rank : 64)
Query Neighborhood Hits	446	Target Neighborhood Hits	413	Shared Neighborhood Hits	118
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

CNKR2_MOUSE
NC score	0.227423 (rank : 88)	θ value	0.000270298 (rank : 30)
Query Neighborhood Hits	446	Target Neighborhood Hits	197	Shared Neighborhood Hits	73
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.227306 (rank : 89)	θ value	0.000270298 (rank : 29)
Query Neighborhood Hits	446	Target Neighborhood Hits	197	Shared Neighborhood Hits	73
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

SNTG2_HUMAN
NC score	0.226846 (rank : 90)	θ value	0.813845 (rank : 231)
Query Neighborhood Hits	446	Target Neighborhood Hits	191	Shared Neighborhood Hits	115
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

GRIP1_MOUSE
NC score	0.226343 (rank : 91)	θ value	6.88961 (rank : 399)
Query Neighborhood Hits	446	Target Neighborhood Hits	241	Shared Neighborhood Hits	119
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

DLG4_MOUSE
NC score	0.226213 (rank : 92)	θ value	6.88961 (rank : 392)
Query Neighborhood Hits	446	Target Neighborhood Hits	282	Shared Neighborhood Hits	153
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

APBA1_HUMAN
NC score	0.225851 (rank : 93)	θ value	0.0563607 (rank : 115)
Query Neighborhood Hits	446	Target Neighborhood Hits	325	Shared Neighborhood Hits	115
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

SRC8_HUMAN
NC score	0.224329 (rank : 94)	θ value	0.0961366 (rank : 148)
Query Neighborhood Hits	446	Target Neighborhood Hits	269	Shared Neighborhood Hits	109
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

APBA2_MOUSE
NC score	0.224275 (rank : 95)	θ value	0.0736092 (rank : 126)
Query Neighborhood Hits	446	Target Neighborhood Hits	219	Shared Neighborhood Hits	109
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

DLG4_HUMAN
NC score	0.223953 (rank : 96)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	446	Target Neighborhood Hits	286	Shared Neighborhood Hits	151
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

GRAP_MOUSE
NC score	0.223820 (rank : 97)	θ value	0.163984 (rank : 162)
Query Neighborhood Hits	446	Target Neighborhood Hits	309	Shared Neighborhood Hits	123
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

APBA2_HUMAN
NC score	0.223702 (rank : 98)	θ value	0.0736092 (rank : 125)
Query Neighborhood Hits	446	Target Neighborhood Hits	220	Shared Neighborhood Hits	108
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

SRC8_MOUSE
NC score	0.223421 (rank : 99)	θ value	0.0961366 (rank : 149)
Query Neighborhood Hits	446	Target Neighborhood Hits	292	Shared Neighborhood Hits	114
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

DNMBP_MOUSE
NC score	0.223051 (rank : 100)	θ value	0.163984 (rank : 161)
Query Neighborhood Hits	446	Target Neighborhood Hits	435	Shared Neighborhood Hits	128
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

HCLS1_MOUSE
NC score	0.222839 (rank : 101)	θ value	0.0563607 (rank : 120)
Query Neighborhood Hits	446	Target Neighborhood Hits	329	Shared Neighborhood Hits	121
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

VINEX_MOUSE
NC score	0.222336 (rank : 102)	θ value	0.0736092 (rank : 142)
Query Neighborhood Hits	446	Target Neighborhood Hits	286	Shared Neighborhood Hits	111
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

APBA3_MOUSE
NC score	0.220679 (rank : 103)	θ value	0.279714 (rank : 183)
Query Neighborhood Hits	446	Target Neighborhood Hits	174	Shared Neighborhood Hits	105
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

GRAP_HUMAN
NC score	0.219904 (rank : 104)	θ value	0.21417 (rank : 171)
Query Neighborhood Hits	446	Target Neighborhood Hits	307	Shared Neighborhood Hits	123
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

SYP2L_HUMAN
NC score	0.216906 (rank : 105)	θ value	0.0961366 (rank : 150)
Query Neighborhood Hits	446	Target Neighborhood Hits	400	Shared Neighborhood Hits	139
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

VINEX_HUMAN
NC score	0.216195 (rank : 106)	θ value	0.813845 (rank : 232)
Query Neighborhood Hits	446	Target Neighborhood Hits	270	Shared Neighborhood Hits	111
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

SH3G2_HUMAN
NC score	0.214827 (rank : 107)	θ value	0.00509761 (rank : 79)
Query Neighborhood Hits	446	Target Neighborhood Hits	324	Shared Neighborhood Hits	107
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

PAR3L_HUMAN
NC score	0.214593 (rank : 108)	θ value	θ > 10 (rank : 700)
Query Neighborhood Hits	446	Target Neighborhood Hits	297	Shared Neighborhood Hits	98
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

HCLS1_HUMAN
NC score	0.214474 (rank : 109)	θ value	0.21417 (rank : 172)
Query Neighborhood Hits	446	Target Neighborhood Hits	358	Shared Neighborhood Hits	120
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

SH3G2_MOUSE
NC score	0.212386 (rank : 110)	θ value	0.0113563 (rank : 87)
Query Neighborhood Hits	446	Target Neighborhood Hits	319	Shared Neighborhood Hits	107
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SAMD9_HUMAN
NC score	0.210563 (rank : 111)	θ value	6.43352e-06 (rank : 12)
Query Neighborhood Hits	446	Target Neighborhood Hits	79	Shared Neighborhood Hits	15
SwissProt Accessions	Q5K651, Q6P080, Q75N21, Q8IVG6, Q9NXS8	Gene names	SAMD9, KIAA2004, OEF1
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 9.

NCF1_MOUSE
NC score	0.210419 (rank : 112)	θ value	0.813845 (rank : 226)
Query Neighborhood Hits	446	Target Neighborhood Hits	198	Shared Neighborhood Hits	102
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

LNX2_HUMAN
NC score	0.209180 (rank : 113)	θ value	5.27518 (rank : 364)
Query Neighborhood Hits	446	Target Neighborhood Hits	389	Shared Neighborhood Hits	112
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

SRBS1_MOUSE
NC score	0.207351 (rank : 114)	θ value	4.03905 (rank : 353)
Query Neighborhood Hits	446	Target Neighborhood Hits	409	Shared Neighborhood Hits	120
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

LNX2_MOUSE
NC score	0.205538 (rank : 115)	θ value	5.27518 (rank : 365)
Query Neighborhood Hits	446	Target Neighborhood Hits	407	Shared Neighborhood Hits	115
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

ABI2_HUMAN
NC score	0.203562 (rank : 116)	θ value	2.36792 (rank : 291)
Query Neighborhood Hits	446	Target Neighborhood Hits	350	Shared Neighborhood Hits	149
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

SNTG2_MOUSE
NC score	0.202543 (rank : 117)	θ value	5.27518 (rank : 379)
Query Neighborhood Hits	446	Target Neighborhood Hits	176	Shared Neighborhood Hits	108
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SH3G3_MOUSE
NC score	0.202224 (rank : 118)	θ value	0.47712 (rank : 205)
Query Neighborhood Hits	446	Target Neighborhood Hits	236	Shared Neighborhood Hits	102
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SRBS1_HUMAN
NC score	0.201640 (rank : 119)	θ value	3.0926 (rank : 332)
Query Neighborhood Hits	446	Target Neighborhood Hits	396	Shared Neighborhood Hits	126
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SNTA1_HUMAN
NC score	0.200819 (rank : 120)	θ value	0.62314 (rank : 220)
Query Neighborhood Hits	446	Target Neighborhood Hits	186	Shared Neighborhood Hits	107
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

RHPN1_HUMAN
NC score	0.200690 (rank : 121)	θ value	0.813845 (rank : 229)
Query Neighborhood Hits	446	Target Neighborhood Hits	158	Shared Neighborhood Hits	96
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

SH3G1_HUMAN
NC score	0.199337 (rank : 122)	θ value	0.0736092 (rank : 138)
Query Neighborhood Hits	446	Target Neighborhood Hits	307	Shared Neighborhood Hits	108
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

RPGF6_HUMAN
NC score	0.198702 (rank : 123)	θ value	0.0563607 (rank : 124)
Query Neighborhood Hits	446	Target Neighborhood Hits	266	Shared Neighborhood Hits	113
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

NCF2_HUMAN
NC score	0.198595 (rank : 124)	θ value	θ > 10 (rank : 670)
Query Neighborhood Hits	446	Target Neighborhood Hits	229	Shared Neighborhood Hits	108
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

LAP4_HUMAN
NC score	0.197767 (rank : 125)	θ value	0.000786445 (rank : 43)
Query Neighborhood Hits	446	Target Neighborhood Hits	608	Shared Neighborhood Hits	147
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

GRAP2_HUMAN
NC score	0.197424 (rank : 126)	θ value	1.38821 (rank : 253)
Query Neighborhood Hits	446	Target Neighborhood Hits	304	Shared Neighborhood Hits	117
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

OSTF1_HUMAN
NC score	0.197141 (rank : 127)	θ value	0.0736092 (rank : 134)
Query Neighborhood Hits	446	Target Neighborhood Hits	466	Shared Neighborhood Hits	125
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

K1849_HUMAN
NC score	0.196330 (rank : 128)	θ value	1.38821 (rank : 255)
Query Neighborhood Hits	446	Target Neighborhood Hits	220	Shared Neighborhood Hits	102
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

SNTA1_MOUSE
NC score	0.195856 (rank : 129)	θ value	1.06291 (rank : 244)
Query Neighborhood Hits	446	Target Neighborhood Hits	170	Shared Neighborhood Hits	104
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

SH3G1_MOUSE
NC score	0.194732 (rank : 130)	θ value	0.62314 (rank : 219)
Query Neighborhood Hits	446	Target Neighborhood Hits	291	Shared Neighborhood Hits	108
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SNTB2_HUMAN
NC score	0.194040 (rank : 131)	θ value	5.27518 (rank : 377)
Query Neighborhood Hits	446	Target Neighborhood Hits	180	Shared Neighborhood Hits	104
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

OSTF1_MOUSE
NC score	0.194033 (rank : 132)	θ value	0.0961366 (rank : 146)
Query Neighborhood Hits	446	Target Neighborhood Hits	467	Shared Neighborhood Hits	123
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

SNTB2_MOUSE
NC score	0.193813 (rank : 133)	θ value	5.27518 (rank : 378)
Query Neighborhood Hits	446	Target Neighborhood Hits	181	Shared Neighborhood Hits	101
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

ITSN2_HUMAN
NC score	0.193278 (rank : 134)	θ value	0.0193708 (rank : 99)
Query Neighborhood Hits	446	Target Neighborhood Hits	1173	Shared Neighborhood Hits	152
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ABI2_MOUSE
NC score	0.193253 (rank : 135)	θ value	2.36792 (rank : 292)
Query Neighborhood Hits	446	Target Neighborhood Hits	266	Shared Neighborhood Hits	126
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

SH3G3_HUMAN
NC score	0.192185 (rank : 136)	θ value	2.36792 (rank : 305)
Query Neighborhood Hits	446	Target Neighborhood Hits	222	Shared Neighborhood Hits	99
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

LAP4_MOUSE
NC score	0.191998 (rank : 137)	θ value	0.000270298 (rank : 31)
Query Neighborhood Hits	446	Target Neighborhood Hits	590	Shared Neighborhood Hits	145
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

GRAP2_MOUSE
NC score	0.191889 (rank : 138)	θ value	θ > 10 (rank : 588)
Query Neighborhood Hits	446	Target Neighborhood Hits	297	Shared Neighborhood Hits	116
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

STAM1_MOUSE
NC score	0.189246 (rank : 139)	θ value	1.81305 (rank : 290)
Query Neighborhood Hits	446	Target Neighborhood Hits	273	Shared Neighborhood Hits	121
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

NEB1_HUMAN
NC score	0.187689 (rank : 140)	θ value	0.0252991 (rank : 105)
Query Neighborhood Hits	446	Target Neighborhood Hits	829	Shared Neighborhood Hits	120
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

RPGF2_HUMAN
NC score	0.187640 (rank : 141)	θ value	0.0148317 (rank : 92)
Query Neighborhood Hits	446	Target Neighborhood Hits	242	Shared Neighborhood Hits	108
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

PZRN3_MOUSE
NC score	0.187112 (rank : 142)	θ value	0.21417 (rank : 176)
Query Neighborhood Hits	446	Target Neighborhood Hits	447	Shared Neighborhood Hits	104
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

STAM1_HUMAN
NC score	0.186861 (rank : 143)	θ value	1.81305 (rank : 289)
Query Neighborhood Hits	446	Target Neighborhood Hits	271	Shared Neighborhood Hits	117
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ITSN2_MOUSE
NC score	0.185946 (rank : 144)	θ value	0.0252991 (rank : 104)
Query Neighborhood Hits	446	Target Neighborhood Hits	1371	Shared Neighborhood Hits	154
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

SDCB1_MOUSE
NC score	0.185356 (rank : 145)	θ value	6.88961 (rank : 409)
Query Neighborhood Hits	446	Target Neighborhood Hits	144	Shared Neighborhood Hits	99
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

ITSN1_MOUSE
NC score	0.183725 (rank : 146)	θ value	0.00869519 (rank : 84)
Query Neighborhood Hits	446	Target Neighborhood Hits	1669	Shared Neighborhood Hits	178
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

STAC3_MOUSE
NC score	0.183486 (rank : 147)	θ value	5.27518 (rank : 382)
Query Neighborhood Hits	446	Target Neighborhood Hits	232	Shared Neighborhood Hits	101
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ARHG9_HUMAN
NC score	0.182223 (rank : 148)	θ value	0.62314 (rank : 208)
Query Neighborhood Hits	446	Target Neighborhood Hits	235	Shared Neighborhood Hits	107
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.182189 (rank : 149)	θ value	1.06291 (rank : 237)
Query Neighborhood Hits	446	Target Neighborhood Hits	234	Shared Neighborhood Hits	105
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

CRK_MOUSE
NC score	0.181375 (rank : 150)	θ value	1.38821 (rank : 249)
Query Neighborhood Hits	446	Target Neighborhood Hits	314	Shared Neighborhood Hits	118
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

PZRN3_HUMAN
NC score	0.181216 (rank : 151)	θ value	0.47712 (rank : 203)
Query Neighborhood Hits	446	Target Neighborhood Hits	461	Shared Neighborhood Hits	103
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

ITSN1_HUMAN
NC score	0.180733 (rank : 152)	θ value	0.0563607 (rank : 121)
Query Neighborhood Hits	446	Target Neighborhood Hits	1757	Shared Neighborhood Hits	176
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

K1849_MOUSE
NC score	0.178567 (rank : 153)	θ value	3.0926 (rank : 317)
Query Neighborhood Hits	446	Target Neighborhood Hits	335	Shared Neighborhood Hits	108
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

CRKL_HUMAN
NC score	0.178055 (rank : 154)	θ value	8.99809 (rank : 421)
Query Neighborhood Hits	446	Target Neighborhood Hits	313	Shared Neighborhood Hits	117
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

STAC3_HUMAN
NC score	0.177450 (rank : 155)	θ value	θ > 10 (rank : 814)
Query Neighborhood Hits	446	Target Neighborhood Hits	228	Shared Neighborhood Hits	100
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

PDLI2_MOUSE
NC score	0.177056 (rank : 156)	θ value	1.81305 (rank : 283)
Query Neighborhood Hits	446	Target Neighborhood Hits	220	Shared Neighborhood Hits	94
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

CRK_HUMAN
NC score	0.177056 (rank : 157)	θ value	1.81305 (rank : 271)
Query Neighborhood Hits	446	Target Neighborhood Hits	308	Shared Neighborhood Hits	119
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

ABI1_MOUSE
NC score	0.176006 (rank : 158)	θ value	8.99809 (rank : 417)
Query Neighborhood Hits	446	Target Neighborhood Hits	246	Shared Neighborhood Hits	117
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

CRKL_MOUSE
NC score	0.175928 (rank : 159)	θ value	8.99809 (rank : 422)
Query Neighborhood Hits	446	Target Neighborhood Hits	307	Shared Neighborhood Hits	114
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

PPIP1_HUMAN
NC score	0.175658 (rank : 160)	θ value	0.125558 (rank : 157)
Query Neighborhood Hits	446	Target Neighborhood Hits	389	Shared Neighborhood Hits	113
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

ABI1_HUMAN
NC score	0.175275 (rank : 161)	θ value	8.99809 (rank : 416)
Query Neighborhood Hits	446	Target Neighborhood Hits	257	Shared Neighborhood Hits	122
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

IL16_HUMAN
NC score	0.175004 (rank : 162)	θ value	θ > 10 (rank : 597)
Query Neighborhood Hits	446	Target Neighborhood Hits	207	Shared Neighborhood Hits	97
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

SDCB2_MOUSE
NC score	0.174619 (rank : 163)	θ value	1.06291 (rank : 243)
Query Neighborhood Hits	446	Target Neighborhood Hits	118	Shared Neighborhood Hits	82
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

PPIP1_MOUSE
NC score	0.174127 (rank : 164)	θ value	0.62314 (rank : 217)
Query Neighborhood Hits	446	Target Neighborhood Hits	377	Shared Neighborhood Hits	119
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PDLI2_HUMAN
NC score	0.173376 (rank : 165)	θ value	2.36792 (rank : 303)
Query Neighborhood Hits	446	Target Neighborhood Hits	245	Shared Neighborhood Hits	98
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

SDCB2_HUMAN
NC score	0.172800 (rank : 166)	θ value	1.38821 (rank : 263)
Query Neighborhood Hits	446	Target Neighborhood Hits	121	Shared Neighborhood Hits	86
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

STAM2_HUMAN
NC score	0.172032 (rank : 167)	θ value	6.88961 (rank : 410)
Query Neighborhood Hits	446	Target Neighborhood Hits	288	Shared Neighborhood Hits	115
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
NC score	0.171613 (rank : 168)	θ value	θ > 10 (rank : 815)
Query Neighborhood Hits	446	Target Neighborhood Hits	285	Shared Neighborhood Hits	112
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

RIMB2_MOUSE
NC score	0.171419 (rank : 169)	θ value	0.0330416 (rank : 110)
Query Neighborhood Hits	446	Target Neighborhood Hits	246	Shared Neighborhood Hits	80
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

MPP4_HUMAN
NC score	0.170749 (rank : 170)	θ value	1.81305 (rank : 280)
Query Neighborhood Hits	446	Target Neighborhood Hits	205	Shared Neighborhood Hits	124
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

ARHG4_HUMAN
NC score	0.170429 (rank : 171)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	446	Target Neighborhood Hits	242	Shared Neighborhood Hits	108
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ZO3_MOUSE
NC score	0.169199 (rank : 172)	θ value	θ > 10 (rank : 853)
Query Neighborhood Hits	446	Target Neighborhood Hits	224	Shared Neighborhood Hits	113
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

RIMB2_HUMAN
NC score	0.169007 (rank : 173)	θ value	0.0431538 (rank : 112)
Query Neighborhood Hits	446	Target Neighborhood Hits	263	Shared Neighborhood Hits	85
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

ZO3_HUMAN
NC score	0.168922 (rank : 174)	θ value	θ > 10 (rank : 852)
Query Neighborhood Hits	446	Target Neighborhood Hits	219	Shared Neighborhood Hits	117
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

SDCB1_HUMAN
NC score	0.166845 (rank : 175)	θ value	θ > 10 (rank : 768)
Query Neighborhood Hits	446	Target Neighborhood Hits	150	Shared Neighborhood Hits	103
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

ZO2_HUMAN
NC score	0.165666 (rank : 176)	θ value	1.38821 (rank : 267)
Query Neighborhood Hits	446	Target Neighborhood Hits	289	Shared Neighborhood Hits	118
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

IL16_MOUSE
NC score	0.163972 (rank : 177)	θ value	θ > 10 (rank : 598)
Query Neighborhood Hits	446	Target Neighborhood Hits	189	Shared Neighborhood Hits	89
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

PZRN4_HUMAN
NC score	0.163831 (rank : 178)	θ value	θ > 10 (rank : 738)
Query Neighborhood Hits	446	Target Neighborhood Hits	438	Shared Neighborhood Hits	99
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

SYP2L_MOUSE
NC score	0.162234 (rank : 179)	θ value	2.36792 (rank : 306)
Query Neighborhood Hits	446	Target Neighborhood Hits	289	Shared Neighborhood Hits	111
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

SNTB1_HUMAN
NC score	0.160542 (rank : 180)	θ value	θ > 10 (rank : 795)
Query Neighborhood Hits	446	Target Neighborhood Hits	157	Shared Neighborhood Hits	95
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

SNTB1_MOUSE
NC score	0.160104 (rank : 181)	θ value	θ > 10 (rank : 796)
Query Neighborhood Hits	446	Target Neighborhood Hits	160	Shared Neighborhood Hits	95
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

TIAM1_HUMAN
NC score	0.159990 (rank : 182)	θ value	1.38821 (rank : 265)
Query Neighborhood Hits	446	Target Neighborhood Hits	225	Shared Neighborhood Hits	81
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG4_MOUSE
NC score	0.157278 (rank : 183)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	446	Target Neighborhood Hits	185	Shared Neighborhood Hits	90
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

RGS12_HUMAN
NC score	0.156586 (rank : 184)	θ value	0.62314 (rank : 218)
Query Neighborhood Hits	446	Target Neighborhood Hits	333	Shared Neighborhood Hits	119
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

ZO2_MOUSE
NC score	0.156494 (rank : 185)	θ value	4.03905 (rank : 356)
Query Neighborhood Hits	446	Target Neighborhood Hits	296	Shared Neighborhood Hits	120
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZO1_MOUSE
NC score	0.155779 (rank : 186)	θ value	θ > 10 (rank : 851)
Query Neighborhood Hits	446	Target Neighborhood Hits	453	Shared Neighborhood Hits	154
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

NCF4_MOUSE
NC score	0.154387 (rank : 187)	θ value	θ > 10 (rank : 672)
Query Neighborhood Hits	446	Target Neighborhood Hits	177	Shared Neighborhood Hits	90
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

PLCG2_HUMAN
NC score	0.154251 (rank : 188)	θ value	0.62314 (rank : 216)
Query Neighborhood Hits	446	Target Neighborhood Hits	280	Shared Neighborhood Hits	98
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

NOXO1_MOUSE
NC score	0.151594 (rank : 189)	θ value	3.0926 (rank : 325)
Query Neighborhood Hits	446	Target Neighborhood Hits	114	Shared Neighborhood Hits	72
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

DBNL_MOUSE
NC score	0.151027 (rank : 190)	θ value	3.0926 (rank : 313)
Query Neighborhood Hits	446	Target Neighborhood Hits	306	Shared Neighborhood Hits	100
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

EFS_MOUSE
NC score	0.150981 (rank : 191)	θ value	0.0961366 (rank : 143)
Query Neighborhood Hits	446	Target Neighborhood Hits	389	Shared Neighborhood Hits	125
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

DLG5_HUMAN
NC score	0.150484 (rank : 192)	θ value	3.0926 (rank : 314)
Query Neighborhood Hits	446	Target Neighborhood Hits	1088	Shared Neighborhood Hits	168
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

DBNL_HUMAN
NC score	0.150299 (rank : 193)	θ value	3.0926 (rank : 312)
Query Neighborhood Hits	446	Target Neighborhood Hits	244	Shared Neighborhood Hits	91
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

EFS_HUMAN
NC score	0.150062 (rank : 194)	θ value	1.81305 (rank : 273)
Query Neighborhood Hits	446	Target Neighborhood Hits	348	Shared Neighborhood Hits	126
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

ZO1_HUMAN
NC score	0.149561 (rank : 195)	θ value	θ > 10 (rank : 850)
Query Neighborhood Hits	446	Target Neighborhood Hits	474	Shared Neighborhood Hits	150
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

TIAM1_MOUSE
NC score	0.149242 (rank : 196)	θ value	1.38821 (rank : 266)
Query Neighborhood Hits	446	Target Neighborhood Hits	205	Shared Neighborhood Hits	61
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ABI3_HUMAN
NC score	0.148604 (rank : 197)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	446	Target Neighborhood Hits	227	Shared Neighborhood Hits	116
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

SARM1_MOUSE
NC score	0.148266 (rank : 198)	θ value	0.0961366 (rank : 147)
Query Neighborhood Hits	446	Target Neighborhood Hits	54	Shared Neighborhood Hits	33
SwissProt Accessions	Q6PDS3, Q5SYG5, Q5SYG6, Q6A054, Q6SZW0, Q8BRI9	Gene names	Sarm1, Kiaa0524
Domain Architecture	No domain graphic available
Description	Sterile alpha and TIR motif-containing protein 1 (Tir-1 homolog).

ABI3_MOUSE
NC score	0.147439 (rank : 199)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	446	Target Neighborhood Hits	227	Shared Neighborhood Hits	108
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

NCF4_HUMAN
NC score	0.147084 (rank : 200)	θ value	θ > 10 (rank : 671)
Query Neighborhood Hits	446	Target Neighborhood Hits	161	Shared Neighborhood Hits	83
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

PLCG1_MOUSE
NC score	0.146481 (rank : 201)	θ value	θ > 10 (rank : 728)
Query Neighborhood Hits	446	Target Neighborhood Hits	314	Shared Neighborhood Hits	101
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_HUMAN
NC score	0.145809 (rank : 202)	θ value	8.99809 (rank : 441)
Query Neighborhood Hits	446	Target Neighborhood Hits	293	Shared Neighborhood Hits	98
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

MPP4_MOUSE
NC score	0.145452 (rank : 203)	θ value	6.88961 (rank : 403)
Query Neighborhood Hits	446	Target Neighborhood Hits	188	Shared Neighborhood Hits	113
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

AFAD_HUMAN
NC score	0.144332 (rank : 204)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	446	Target Neighborhood Hits	689	Shared Neighborhood Hits	125
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

AHI1_HUMAN
NC score	0.142208 (rank : 205)	θ value	0.47712 (rank : 198)
Query Neighborhood Hits	446	Target Neighborhood Hits	537	Shared Neighborhood Hits	109
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
NC score	0.142037 (rank : 206)	θ value	0.125558 (rank : 152)
Query Neighborhood Hits	446	Target Neighborhood Hits	496	Shared Neighborhood Hits	109
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

CNKR1_HUMAN
NC score	0.140965 (rank : 207)	θ value	0.0563607 (rank : 117)
Query Neighborhood Hits	446	Target Neighborhood Hits	154	Shared Neighborhood Hits	32
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

SI1L3_HUMAN
NC score	0.139095 (rank : 208)	θ value	0.00869519 (rank : 85)
Query Neighborhood Hits	446	Target Neighborhood Hits	305	Shared Neighborhood Hits	67
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

PTN13_HUMAN
NC score	0.138113 (rank : 209)	θ value	1.81305 (rank : 285)
Query Neighborhood Hits	446	Target Neighborhood Hits	471	Shared Neighborhood Hits	122
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

SAMH1_MOUSE
NC score	0.137543 (rank : 210)	θ value	0.000602161 (rank : 39)
Query Neighborhood Hits	446	Target Neighborhood Hits	19	Shared Neighborhood Hits	9
SwissProt Accessions	Q60710, Q91VK8	Gene names	Samhd1, Mg11
Domain Architecture
Description	SAM domain and HD domain-containing protein 1 (Interferon-gamma- inducible protein Mg11).

BCAR1_HUMAN
NC score	0.135925 (rank : 211)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	446	Target Neighborhood Hits	554	Shared Neighborhood Hits	140
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

SARM1_HUMAN
NC score	0.135687 (rank : 212)	θ value	0.0736092 (rank : 136)
Query Neighborhood Hits	446	Target Neighborhood Hits	58	Shared Neighborhood Hits	28
SwissProt Accessions	Q6SZW1, O60277, Q7LGG3, Q9NXY5	Gene names	SARM1, KIAA0524, SARM
Domain Architecture	No domain graphic available
Description	Sterile alpha and TIR motif-containing protein 1 (Sterile alpha and Armadillo repeat protein) (Tir-1 homolog).

PACN1_HUMAN
NC score	0.135387 (rank : 213)	θ value	θ > 10 (rank : 694)
Query Neighborhood Hits	446	Target Neighborhood Hits	320	Shared Neighborhood Hits	109
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

SAM10_MOUSE
NC score	0.135071 (rank : 214)	θ value	0.163984 (rank : 164)
Query Neighborhood Hits	446	Target Neighborhood Hits	23	Shared Neighborhood Hits	17
SwissProt Accessions	Q7TST3	Gene names	Samd10
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 10.

SI1L2_HUMAN
NC score	0.134808 (rank : 215)	θ value	0.0431538 (rank : 113)
Query Neighborhood Hits	446	Target Neighborhood Hits	131	Shared Neighborhood Hits	43
SwissProt Accessions	Q9P2F8, Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6	Gene names	SIPA1L2, KIAA1389
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

EM55_HUMAN
NC score	0.134800 (rank : 216)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	446	Target Neighborhood Hits	228	Shared Neighborhood Hits	144
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

ARHG5_HUMAN
NC score	0.134567 (rank : 217)	θ value	0.125558 (rank : 154)
Query Neighborhood Hits	446	Target Neighborhood Hits	172	Shared Neighborhood Hits	76
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

SI1L1_MOUSE
NC score	0.133426 (rank : 218)	θ value	0.0148317 (rank : 94)
Query Neighborhood Hits	446	Target Neighborhood Hits	189	Shared Neighborhood Hits	42
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

PACN1_MOUSE
NC score	0.133402 (rank : 219)	θ value	θ > 10 (rank : 695)
Query Neighborhood Hits	446	Target Neighborhood Hits	283	Shared Neighborhood Hits	106
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

SAM10_HUMAN
NC score	0.133316 (rank : 220)	θ value	0.279714 (rank : 189)
Query Neighborhood Hits	446	Target Neighborhood Hits	20	Shared Neighborhood Hits	17
SwissProt Accessions	Q9BYL1	Gene names	SAMD10, C20orf136
Domain Architecture
Description	Sterile alpha motif domain-containing protein 10.

PTN13_MOUSE
NC score	0.133132 (rank : 221)	θ value	5.27518 (rank : 373)
Query Neighborhood Hits	446	Target Neighborhood Hits	426	Shared Neighborhood Hits	121
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

SI1L2_MOUSE
NC score	0.131793 (rank : 222)	θ value	0.0736092 (rank : 139)
Query Neighborhood Hits	446	Target Neighborhood Hits	124	Shared Neighborhood Hits	43
SwissProt Accessions	Q80TE4, Q6PDY1	Gene names	Sipa1l2, Kiaa0545
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

SI1L1_HUMAN
NC score	0.131771 (rank : 223)	θ value	0.0148317 (rank : 93)
Query Neighborhood Hits	446	Target Neighborhood Hits	162	Shared Neighborhood Hits	41
SwissProt Accessions	O43166, O95321, Q9UDU4, Q9UNU4	Gene names	SIPA1L1, E6TP1, KIAA0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1 (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6- targeted protein 1).

PACN2_MOUSE
NC score	0.131569 (rank : 224)	θ value	θ > 10 (rank : 697)
Query Neighborhood Hits	446	Target Neighborhood Hits	382	Shared Neighborhood Hits	114
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

LIPB2_MOUSE
NC score	0.131553 (rank : 225)	θ value	0.00509761 (rank : 76)
Query Neighborhood Hits	446	Target Neighborhood Hits	570	Shared Neighborhood Hits	46
SwissProt Accessions	O35711, Q7TMG4, Q8CBS6, Q99KX6	Gene names	Ppfibp2, Cclp1
Domain Architecture
Description	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) (Coiled-coil-like protein 1).

LASP1_HUMAN
NC score	0.131328 (rank : 226)	θ value	θ > 10 (rank : 622)
Query Neighborhood Hits	446	Target Neighborhood Hits	293	Shared Neighborhood Hits	100
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
NC score	0.131234 (rank : 227)	θ value	θ > 10 (rank : 623)
Query Neighborhood Hits	446	Target Neighborhood Hits	297	Shared Neighborhood Hits	101
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

CT032_HUMAN
NC score	0.131021 (rank : 228)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	446	Target Neighborhood Hits	235	Shared Neighborhood Hits	96
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

LIPB2_HUMAN
NC score	0.129790 (rank : 229)	θ value	0.00509761 (rank : 75)
Query Neighborhood Hits	446	Target Neighborhood Hits	599	Shared Neighborhood Hits	43
SwissProt Accessions	Q8ND30, O75337, Q8WW26	Gene names	PPFIBP2
Domain Architecture
Description	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2).

NEB2_HUMAN
NC score	0.129512 (rank : 230)	θ value	θ > 10 (rank : 673)
Query Neighborhood Hits	446	Target Neighborhood Hits	883	Shared Neighborhood Hits	113
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

EM55_MOUSE
NC score	0.128705 (rank : 231)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	446	Target Neighborhood Hits	221	Shared Neighborhood Hits	143
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

PACN2_HUMAN
NC score	0.128657 (rank : 232)	θ value	θ > 10 (rank : 696)
Query Neighborhood Hits	446	Target Neighborhood Hits	339	Shared Neighborhood Hits	106
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

NEB2_MOUSE
NC score	0.128299 (rank : 233)	θ value	θ > 10 (rank : 674)
Query Neighborhood Hits	446	Target Neighborhood Hits	889	Shared Neighborhood Hits	105
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

LIPB1_HUMAN
NC score	0.128102 (rank : 234)	θ value	0.00298849 (rank : 65)
Query Neighborhood Hits	446	Target Neighborhood Hits	640	Shared Neighborhood Hits	46
SwissProt Accessions	Q86W92, O75336, Q86X70, Q9NY03, Q9ULJ0	Gene names	PPFIBP1, KIAA1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2).

SYNP2_MOUSE
NC score	0.127423 (rank : 235)	θ value	θ > 10 (rank : 825)
Query Neighborhood Hits	446	Target Neighborhood Hits	252	Shared Neighborhood Hits	108
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

LIPB1_MOUSE
NC score	0.126941 (rank : 236)	θ value	0.00298849 (rank : 66)
Query Neighborhood Hits	446	Target Neighborhood Hits	727	Shared Neighborhood Hits	55
SwissProt Accessions	Q8C8U0, Q69ZN5, Q6GQV3, Q80VB4, Q9CUT7	Gene names	Ppfibp1, Kiaa1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1).

BCAR1_MOUSE
NC score	0.126817 (rank : 237)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	446	Target Neighborhood Hits	438	Shared Neighborhood Hits	136
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

NEBL_HUMAN
NC score	0.126088 (rank : 238)	θ value	θ > 10 (rank : 675)
Query Neighborhood Hits	446	Target Neighborhood Hits	457	Shared Neighborhood Hits	99
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NPHP1_MOUSE
NC score	0.124849 (rank : 239)	θ value	θ > 10 (rank : 682)
Query Neighborhood Hits	446	Target Neighborhood Hits	267	Shared Neighborhood Hits	106
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

PREX1_HUMAN
NC score	0.123201 (rank : 240)	θ value	θ > 10 (rank : 731)
Query Neighborhood Hits	446	Target Neighborhood Hits	177	Shared Neighborhood Hits	58
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

APXL_HUMAN
NC score	0.122235 (rank : 241)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	446	Target Neighborhood Hits	553	Shared Neighborhood Hits	107
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

MPP3_MOUSE
NC score	0.122177 (rank : 242)	θ value	θ > 10 (rank : 661)
Query Neighborhood Hits	446	Target Neighborhood Hits	165	Shared Neighborhood Hits	101
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

RIMB1_HUMAN
NC score	0.122025 (rank : 243)	θ value	0.0563607 (rank : 123)
Query Neighborhood Hits	446	Target Neighborhood Hits	1479	Shared Neighborhood Hits	167
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

MPP5_HUMAN
NC score	0.121395 (rank : 244)	θ value	θ > 10 (rank : 662)
Query Neighborhood Hits	446	Target Neighborhood Hits	231	Shared Neighborhood Hits	125
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

PACN3_MOUSE
NC score	0.120875 (rank : 245)	θ value	θ > 10 (rank : 699)
Query Neighborhood Hits	446	Target Neighborhood Hits	380	Shared Neighborhood Hits	108
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

MPP5_MOUSE
NC score	0.120684 (rank : 246)	θ value	θ > 10 (rank : 663)
Query Neighborhood Hits	446	Target Neighborhood Hits	226	Shared Neighborhood Hits	124
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

CSKI2_HUMAN
NC score	0.120451 (rank : 247)	θ value	0.0736092 (rank : 129)
Query Neighborhood Hits	446	Target Neighborhood Hits	747	Shared Neighborhood Hits	134
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

PACN3_HUMAN
NC score	0.119463 (rank : 248)	θ value	θ > 10 (rank : 698)
Query Neighborhood Hits	446	Target Neighborhood Hits	385	Shared Neighborhood Hits	105
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

MPP3_HUMAN
NC score	0.119255 (rank : 249)	θ value	θ > 10 (rank : 660)
Query Neighborhood Hits	446	Target Neighborhood Hits	171	Shared Neighborhood Hits	102
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

CSKI2_MOUSE
NC score	0.118215 (rank : 250)	θ value	0.0193708 (rank : 96)
Query Neighborhood Hits	446	Target Neighborhood Hits	812	Shared Neighborhood Hits	134
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

NGEF_MOUSE
NC score	0.116657 (rank : 251)	θ value	6.88961 (rank : 404)
Query Neighborhood Hits	446	Target Neighborhood Hits	228	Shared Neighborhood Hits	71
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NPHP1_HUMAN
NC score	0.116258 (rank : 252)	θ value	θ > 10 (rank : 681)
Query Neighborhood Hits	446	Target Neighborhood Hits	288	Shared Neighborhood Hits	92
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

PDLI7_HUMAN
NC score	0.115924 (rank : 253)	θ value	0.125558 (rank : 155)
Query Neighborhood Hits	446	Target Neighborhood Hits	547	Shared Neighborhood Hits	115
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

IASPP_HUMAN
NC score	0.115637 (rank : 254)	θ value	θ > 10 (rank : 593)
Query Neighborhood Hits	446	Target Neighborhood Hits	688	Shared Neighborhood Hits	151
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

NOXO1_HUMAN
NC score	0.115596 (rank : 255)	θ value	θ > 10 (rank : 680)
Query Neighborhood Hits	446	Target Neighborhood Hits	100	Shared Neighborhood Hits	64
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

ASPP1_MOUSE
NC score	0.114585 (rank : 256)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	446	Target Neighborhood Hits	1244	Shared Neighborhood Hits	178
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

PDLI4_MOUSE
NC score	0.114176 (rank : 257)	θ value	5.27518 (rank : 369)
Query Neighborhood Hits	446	Target Neighborhood Hits	233	Shared Neighborhood Hits	89
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

TCGAP_MOUSE
NC score	0.113417 (rank : 258)	θ value	0.125558 (rank : 158)
Query Neighborhood Hits	446	Target Neighborhood Hits	409	Shared Neighborhood Hits	112
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

PDLI7_MOUSE
NC score	0.112859 (rank : 259)	θ value	0.125558 (rank : 156)
Query Neighborhood Hits	446	Target Neighborhood Hits	279	Shared Neighborhood Hits	85
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PKHG1_HUMAN
NC score	0.112438 (rank : 260)	θ value	θ > 10 (rank : 726)
Query Neighborhood Hits	446	Target Neighborhood Hits	174	Shared Neighborhood Hits	33
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

CSKI1_MOUSE
NC score	0.112205 (rank : 261)	θ value	0.0736092 (rank : 128)
Query Neighborhood Hits	446	Target Neighborhood Hits	1031	Shared Neighborhood Hits	146
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI1_HUMAN
NC score	0.111506 (rank : 262)	θ value	0.0563607 (rank : 118)
Query Neighborhood Hits	446	Target Neighborhood Hits	997	Shared Neighborhood Hits	148
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

PAR6G_HUMAN
NC score	0.110984 (rank : 263)	θ value	θ > 10 (rank : 705)
Query Neighborhood Hits	446	Target Neighborhood Hits	159	Shared Neighborhood Hits	79
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

PICK1_HUMAN
NC score	0.110744 (rank : 264)	θ value	θ > 10 (rank : 724)
Query Neighborhood Hits	446	Target Neighborhood Hits	132	Shared Neighborhood Hits	74
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

M3K11_HUMAN
NC score	0.110628 (rank : 265)	θ value	0.00134147 (rank : 50)
Query Neighborhood Hits	446	Target Neighborhood Hits	1136	Shared Neighborhood Hits	170
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

PICK1_MOUSE
NC score	0.110093 (rank : 266)	θ value	θ > 10 (rank : 725)
Query Neighborhood Hits	446	Target Neighborhood Hits	131	Shared Neighborhood Hits	74
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

IASPP_MOUSE
NC score	0.110079 (rank : 267)	θ value	θ > 10 (rank : 594)
Query Neighborhood Hits	446	Target Neighborhood Hits	1024	Shared Neighborhood Hits	169
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ARHG1_HUMAN
NC score	0.110071 (rank : 268)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	446	Target Neighborhood Hits	176	Shared Neighborhood Hits	30
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

FYN_MOUSE
NC score	0.109536 (rank : 269)	θ value	0.00509761 (rank : 74)
Query Neighborhood Hits	446	Target Neighborhood Hits	1073	Shared Neighborhood Hits	143
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

SYNP2_HUMAN
NC score	0.109533 (rank : 270)	θ value	θ > 10 (rank : 824)
Query Neighborhood Hits	446	Target Neighborhood Hits	323	Shared Neighborhood Hits	96
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

TCGAP_HUMAN
NC score	0.109209 (rank : 271)	θ value	0.163984 (rank : 168)
Query Neighborhood Hits	446	Target Neighborhood Hits	872	Shared Neighborhood Hits	135
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

PDLI4_HUMAN
NC score	0.109004 (rank : 272)	θ value	θ > 10 (rank : 712)
Query Neighborhood Hits	446	Target Neighborhood Hits	245	Shared Neighborhood Hits	92
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PDLI5_HUMAN
NC score	0.108989 (rank : 273)	θ value	4.03905 (rank : 349)
Query Neighborhood Hits	446	Target Neighborhood Hits	322	Shared Neighborhood Hits	105
SwissProt Accessions	Q96HC4, O60705	Gene names	PDLIM5, ENH
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

M3KL4_HUMAN
NC score	0.108814 (rank : 274)	θ value	0.00665767 (rank : 81)
Query Neighborhood Hits	446	Target Neighborhood Hits	1087	Shared Neighborhood Hits	146
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

CASL_MOUSE
NC score	0.108628 (rank : 275)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	446	Target Neighborhood Hits	225	Shared Neighborhood Hits	94
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

FYN_HUMAN
NC score	0.108529 (rank : 276)	θ value	0.00509761 (rank : 73)
Query Neighborhood Hits	446	Target Neighborhood Hits	1078	Shared Neighborhood Hits	142
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

ARHG1_MOUSE
NC score	0.108495 (rank : 277)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	446	Target Neighborhood Hits	266	Shared Neighborhood Hits	40
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

NGEF_HUMAN
NC score	0.108192 (rank : 278)	θ value	θ > 10 (rank : 677)
Query Neighborhood Hits	446	Target Neighborhood Hits	166	Shared Neighborhood Hits	61
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ANM2_HUMAN
NC score	0.108119 (rank : 279)	θ value	5.27518 (rank : 358)
Query Neighborhood Hits	446	Target Neighborhood Hits	175	Shared Neighborhood Hits	91
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHG3_MOUSE
NC score	0.107631 (rank : 280)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	446	Target Neighborhood Hits	85	Shared Neighborhood Hits	25
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG3_HUMAN
NC score	0.107402 (rank : 281)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	446	Target Neighborhood Hits	82	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ASPP1_HUMAN
NC score	0.106942 (rank : 282)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	446	Target Neighborhood Hits	956	Shared Neighborhood Hits	149
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

PDZK4_MOUSE
NC score	0.106198 (rank : 283)	θ value	θ > 10 (rank : 716)
Query Neighborhood Hits	446	Target Neighborhood Hits	165	Shared Neighborhood Hits	76
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

CASL_HUMAN
NC score	0.106108 (rank : 284)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	446	Target Neighborhood Hits	259	Shared Neighborhood Hits	100
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

PDZK4_HUMAN
NC score	0.105975 (rank : 285)	θ value	θ > 10 (rank : 715)
Query Neighborhood Hits	446	Target Neighborhood Hits	165	Shared Neighborhood Hits	75
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

NACAM_MOUSE
NC score	0.105537 (rank : 286)	θ value	0.21417 (rank : 175)
Query Neighborhood Hits	446	Target Neighborhood Hits	1866	Shared Neighborhood Hits	166
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

PAR6B_MOUSE
NC score	0.105273 (rank : 287)	θ value	θ > 10 (rank : 704)
Query Neighborhood Hits	446	Target Neighborhood Hits	128	Shared Neighborhood Hits	79
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6G_MOUSE
NC score	0.105106 (rank : 288)	θ value	θ > 10 (rank : 706)
Query Neighborhood Hits	446	Target Neighborhood Hits	121	Shared Neighborhood Hits	76
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

PAR6B_HUMAN
NC score	0.105050 (rank : 289)	θ value	θ > 10 (rank : 703)
Query Neighborhood Hits	446	Target Neighborhood Hits	126	Shared Neighborhood Hits	79
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

FGR_HUMAN
NC score	0.104953 (rank : 290)	θ value	1.06291 (rank : 238)
Query Neighborhood Hits	446	Target Neighborhood Hits	1067	Shared Neighborhood Hits	143
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

PDLI1_HUMAN
NC score	0.104801 (rank : 291)	θ value	θ > 10 (rank : 708)
Query Neighborhood Hits	446	Target Neighborhood Hits	242	Shared Neighborhood Hits	80
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

ARHG8_MOUSE
NC score	0.104665 (rank : 292)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	446	Target Neighborhood Hits	79	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

YES_HUMAN
NC score	0.104463 (rank : 293)	θ value	0.0431538 (rank : 114)
Query Neighborhood Hits	446	Target Neighborhood Hits	1059	Shared Neighborhood Hits	145
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
NC score	0.103805 (rank : 294)	θ value	0.62314 (rank : 221)
Query Neighborhood Hits	446	Target Neighborhood Hits	1052	Shared Neighborhood Hits	144
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

PDLI1_MOUSE
NC score	0.103585 (rank : 295)	θ value	θ > 10 (rank : 709)
Query Neighborhood Hits	446	Target Neighborhood Hits	213	Shared Neighborhood Hits	79
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

BLNK_MOUSE
NC score	0.103188 (rank : 296)	θ value	0.163984 (rank : 160)
Query Neighborhood Hits	446	Target Neighborhood Hits	296	Shared Neighborhood Hits	63
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

MPP6_MOUSE
NC score	0.102951 (rank : 297)	θ value	θ > 10 (rank : 665)
Query Neighborhood Hits	446	Target Neighborhood Hits	187	Shared Neighborhood Hits	113
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

PDLI3_HUMAN
NC score	0.102895 (rank : 298)	θ value	θ > 10 (rank : 710)
Query Neighborhood Hits	446	Target Neighborhood Hits	199	Shared Neighborhood Hits	81
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

MPP6_HUMAN
NC score	0.102565 (rank : 299)	θ value	θ > 10 (rank : 664)
Query Neighborhood Hits	446	Target Neighborhood Hits	180	Shared Neighborhood Hits	110
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

SRC_HUMAN
NC score	0.102243 (rank : 300)	θ value	0.279714 (rank : 190)
Query Neighborhood Hits	446	Target Neighborhood Hits	1058	Shared Neighborhood Hits	145
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

ARHGG_MOUSE
NC score	0.101003 (rank : 301)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	446	Target Neighborhood Hits	152	Shared Neighborhood Hits	51
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

PDLI5_MOUSE
NC score	0.100894 (rank : 302)	θ value	5.27518 (rank : 370)
Query Neighborhood Hits	446	Target Neighborhood Hits	287	Shared Neighborhood Hits	98
SwissProt Accessions	Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2	Gene names	Pdlim5, Enh
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

FGR_MOUSE
NC score	0.100480 (rank : 303)	θ value	3.0926 (rank : 316)
Query Neighborhood Hits	446	Target Neighborhood Hits	1069	Shared Neighborhood Hits	146
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

RGS3_MOUSE
NC score	0.100470 (rank : 304)	θ value	1.38821 (rank : 262)
Query Neighborhood Hits	446	Target Neighborhood Hits	1621	Shared Neighborhood Hits	180
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

M3K9_HUMAN
NC score	0.100278 (rank : 305)	θ value	0.813845 (rank : 225)
Query Neighborhood Hits	446	Target Neighborhood Hits	1123	Shared Neighborhood Hits	144
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

ANM2_MOUSE
NC score	0.099978 (rank : 306)	θ value	8.99809 (rank : 420)
Query Neighborhood Hits	446	Target Neighborhood Hits	175	Shared Neighborhood Hits	87
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

DGKK_HUMAN
NC score	0.099969 (rank : 307)	θ value	4.03905 (rank : 339)
Query Neighborhood Hits	446	Target Neighborhood Hits	378	Shared Neighborhood Hits	62
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

M3K10_HUMAN
NC score	0.099955 (rank : 308)	θ value	0.00390308 (rank : 71)
Query Neighborhood Hits	446	Target Neighborhood Hits	1071	Shared Neighborhood Hits	145
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

STXB4_MOUSE
NC score	0.099952 (rank : 309)	θ value	θ > 10 (rank : 820)
Query Neighborhood Hits	446	Target Neighborhood Hits	629	Shared Neighborhood Hits	79
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

PCLO_MOUSE
NC score	0.099818 (rank : 310)	θ value	θ > 10 (rank : 707)
Query Neighborhood Hits	446	Target Neighborhood Hits	2275	Shared Neighborhood Hits	216
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PAR6A_HUMAN
NC score	0.099043 (rank : 311)	θ value	θ > 10 (rank : 701)
Query Neighborhood Hits	446	Target Neighborhood Hits	119	Shared Neighborhood Hits	79
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

STXB4_HUMAN
NC score	0.098944 (rank : 312)	θ value	θ > 10 (rank : 819)
Query Neighborhood Hits	446	Target Neighborhood Hits	616	Shared Neighborhood Hits	78
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

PAR6A_MOUSE
NC score	0.098888 (rank : 313)	θ value	θ > 10 (rank : 702)
Query Neighborhood Hits	446	Target Neighborhood Hits	115	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

MAST4_HUMAN
NC score	0.098770 (rank : 314)	θ value	0.00665767 (rank : 82)
Query Neighborhood Hits	446	Target Neighborhood Hits	1804	Shared Neighborhood Hits	216
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

NEBU_HUMAN
NC score	0.098135 (rank : 315)	θ value	θ > 10 (rank : 676)
Query Neighborhood Hits	446	Target Neighborhood Hits	420	Shared Neighborhood Hits	99
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

MPP2_MOUSE
NC score	0.097835 (rank : 316)	θ value	θ > 10 (rank : 659)
Query Neighborhood Hits	446	Target Neighborhood Hits	189	Shared Neighborhood Hits	112
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

RHG04_HUMAN
NC score	0.097792 (rank : 317)	θ value	θ > 10 (rank : 747)
Query Neighborhood Hits	446	Target Neighborhood Hits	307	Shared Neighborhood Hits	109
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

LDB3_HUMAN
NC score	0.097502 (rank : 318)	θ value	θ > 10 (rank : 626)
Query Neighborhood Hits	446	Target Neighborhood Hits	497	Shared Neighborhood Hits	117
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

PDLI3_MOUSE
NC score	0.097426 (rank : 319)	θ value	θ > 10 (rank : 711)
Query Neighborhood Hits	446	Target Neighborhood Hits	197	Shared Neighborhood Hits	78
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

RIMB1_MOUSE
NC score	0.096675 (rank : 320)	θ value	θ > 10 (rank : 750)
Query Neighborhood Hits	446	Target Neighborhood Hits	1376	Shared Neighborhood Hits	144
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

MPP2_HUMAN
NC score	0.096367 (rank : 321)	θ value	θ > 10 (rank : 658)
Query Neighborhood Hits	446	Target Neighborhood Hits	173	Shared Neighborhood Hits	109
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

PEX13_HUMAN
NC score	0.096016 (rank : 322)	θ value	θ > 10 (rank : 718)
Query Neighborhood Hits	446	Target Neighborhood Hits	128	Shared Neighborhood Hits	69
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

LDB3_MOUSE
NC score	0.095968 (rank : 323)	θ value	θ > 10 (rank : 627)
Query Neighborhood Hits	446	Target Neighborhood Hits	510	Shared Neighborhood Hits	126
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

PEX13_MOUSE
NC score	0.095435 (rank : 324)	θ value	θ > 10 (rank : 719)
Query Neighborhood Hits	446	Target Neighborhood Hits	126	Shared Neighborhood Hits	70
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

DDEF1_MOUSE
NC score	0.095385 (rank : 325)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	446	Target Neighborhood Hits	592	Shared Neighborhood Hits	131
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

ARHG8_HUMAN
NC score	0.095127 (rank : 326)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	446	Target Neighborhood Hits	85	Shared Neighborhood Hits	25
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

FRK_HUMAN
NC score	0.095046 (rank : 327)	θ value	0.00175202 (rank : 55)
Query Neighborhood Hits	446	Target Neighborhood Hits	1058	Shared Neighborhood Hits	142
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

ARHGG_HUMAN
NC score	0.095027 (rank : 328)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	446	Target Neighborhood Hits	129	Shared Neighborhood Hits	43
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

MAST3_HUMAN
NC score	0.095020 (rank : 329)	θ value	0.000158464 (rank : 24)
Query Neighborhood Hits	446	Target Neighborhood Hits	1128	Shared Neighborhood Hits	177
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MAST2_HUMAN
NC score	0.094729 (rank : 330)	θ value	0.00102713 (rank : 46)
Query Neighborhood Hits	446	Target Neighborhood Hits	1189	Shared Neighborhood Hits	178
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

ECT2_MOUSE
NC score	0.094630 (rank : 331)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	446	Target Neighborhood Hits	98	Shared Neighborhood Hits	26
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

MAST1_HUMAN
NC score	0.094237 (rank : 332)	θ value	0.00134147 (rank : 52)
Query Neighborhood Hits	446	Target Neighborhood Hits	1146	Shared Neighborhood Hits	169
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

PRRT3_HUMAN
NC score	0.093554 (rank : 333)	θ value	1.06291 (rank : 242)
Query Neighborhood Hits	446	Target Neighborhood Hits	998	Shared Neighborhood Hits	104
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

MAST2_MOUSE
NC score	0.093085 (rank : 334)	θ value	0.000786445 (rank : 44)
Query Neighborhood Hits	446	Target Neighborhood Hits	1110	Shared Neighborhood Hits	167
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST1_MOUSE
NC score	0.092550 (rank : 335)	θ value	0.00390308 (rank : 72)
Query Neighborhood Hits	446	Target Neighborhood Hits	1123	Shared Neighborhood Hits	166
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

LBC_HUMAN
NC score	0.092291 (rank : 336)	θ value	θ > 10 (rank : 624)
Query Neighborhood Hits	446	Target Neighborhood Hits	90	Shared Neighborhood Hits	23
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ABL1_MOUSE
NC score	0.091826 (rank : 337)	θ value	1.06291 (rank : 234)
Query Neighborhood Hits	446	Target Neighborhood Hits	1178	Shared Neighborhood Hits	149
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

RGNEF_MOUSE
NC score	0.091600 (rank : 338)	θ value	θ > 10 (rank : 745)
Query Neighborhood Hits	446	Target Neighborhood Hits	641	Shared Neighborhood Hits	59
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

EPHA5_HUMAN
NC score	0.091380 (rank : 339)	θ value	0.000786445 (rank : 42)
Query Neighborhood Hits	446	Target Neighborhood Hits	1009	Shared Neighborhood Hits	73
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

SRC_MOUSE
NC score	0.091257 (rank : 340)	θ value	θ > 10 (rank : 806)
Query Neighborhood Hits	446	Target Neighborhood Hits	1033	Shared Neighborhood Hits	127
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

ECT2_HUMAN
NC score	0.091055 (rank : 341)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	446	Target Neighborhood Hits	98	Shared Neighborhood Hits	26
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ABL1_HUMAN
NC score	0.090586 (rank : 342)	θ value	1.06291 (rank : 233)
Query Neighborhood Hits	446	Target Neighborhood Hits	1220	Shared Neighborhood Hits	145
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ASPP2_HUMAN
NC score	0.090503 (rank : 343)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	446	Target Neighborhood Hits	1156	Shared Neighborhood Hits	160
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

NOS1_HUMAN
NC score	0.090173 (rank : 344)	θ value	θ > 10 (rank : 678)
Query Neighborhood Hits	446	Target Neighborhood Hits	218	Shared Neighborhood Hits	94
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

DVL2_HUMAN
NC score	0.089595 (rank : 345)	θ value	6.88961 (rank : 394)
Query Neighborhood Hits	446	Target Neighborhood Hits	223	Shared Neighborhood Hits	79
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

MYO1F_MOUSE
NC score	0.089590 (rank : 346)	θ value	2.36792 (rank : 300)
Query Neighborhood Hits	446	Target Neighborhood Hits	262	Shared Neighborhood Hits	104
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

MYO1F_HUMAN
NC score	0.089502 (rank : 347)	θ value	3.0926 (rank : 323)
Query Neighborhood Hits	446	Target Neighborhood Hits	275	Shared Neighborhood Hits	111
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

EPHB3_MOUSE
NC score	0.089413 (rank : 348)	θ value	0.00390308 (rank : 70)
Query Neighborhood Hits	446	Target Neighborhood Hits	996	Shared Neighborhood Hits	76
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

PRR12_HUMAN
NC score	0.089340 (rank : 349)	θ value	0.813845 (rank : 228)
Query Neighborhood Hits	446	Target Neighborhood Hits	460	Shared Neighborhood Hits	87
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

MYO1E_HUMAN
NC score	0.089022 (rank : 350)	θ value	3.0926 (rank : 322)
Query Neighborhood Hits	446	Target Neighborhood Hits	293	Shared Neighborhood Hits	107
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

EPHB3_HUMAN
NC score	0.088429 (rank : 351)	θ value	0.0113563 (rank : 86)
Query Neighborhood Hits	446	Target Neighborhood Hits	996	Shared Neighborhood Hits	74
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

MCF2L_MOUSE
NC score	0.088173 (rank : 352)	θ value	θ > 10 (rank : 648)
Query Neighborhood Hits	446	Target Neighborhood Hits	255	Shared Neighborhood Hits	40
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

BLNK_HUMAN
NC score	0.087610 (rank : 353)	θ value	0.62314 (rank : 209)
Query Neighborhood Hits	446	Target Neighborhood Hits	228	Shared Neighborhood Hits	45
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

ABL2_HUMAN
NC score	0.087402 (rank : 354)	θ value	1.06291 (rank : 235)
Query Neighborhood Hits	446	Target Neighborhood Hits	1045	Shared Neighborhood Hits	112
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ARHG2_HUMAN
NC score	0.087039 (rank : 355)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	446	Target Neighborhood Hits	142	Shared Neighborhood Hits	30
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

BTK_HUMAN
NC score	0.086984 (rank : 356)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	446	Target Neighborhood Hits	1026	Shared Neighborhood Hits	135
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

ANKS1_HUMAN
NC score	0.086731 (rank : 357)	θ value	0.125558 (rank : 153)
Query Neighborhood Hits	446	Target Neighborhood Hits	438	Shared Neighborhood Hits	62
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

SASH1_HUMAN
NC score	0.086681 (rank : 358)	θ value	5.27518 (rank : 375)
Query Neighborhood Hits	446	Target Neighborhood Hits	292	Shared Neighborhood Hits	104
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

HCK_HUMAN
NC score	0.086239 (rank : 359)	θ value	θ > 10 (rank : 591)
Query Neighborhood Hits	446	Target Neighborhood Hits	1035	Shared Neighborhood Hits	128
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

EPHA6_HUMAN
NC score	0.086205 (rank : 360)	θ value	0.365318 (rank : 192)
Query Neighborhood Hits	446	Target Neighborhood Hits	959	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

HCK_MOUSE
NC score	0.086204 (rank : 361)	θ value	θ > 10 (rank : 592)
Query Neighborhood Hits	446	Target Neighborhood Hits	1029	Shared Neighborhood Hits	127
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

EPHB2_HUMAN
NC score	0.086101 (rank : 362)	θ value	0.0148317 (rank : 90)
Query Neighborhood Hits	446	Target Neighborhood Hits	983	Shared Neighborhood Hits	71
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
NC score	0.085653 (rank : 363)	θ value	0.0148317 (rank : 91)
Query Neighborhood Hits	446	Target Neighborhood Hits	982	Shared Neighborhood Hits	71
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

MCF2_HUMAN
NC score	0.085523 (rank : 364)	θ value	θ > 10 (rank : 649)
Query Neighborhood Hits	446	Target Neighborhood Hits	166	Shared Neighborhood Hits	30
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

BTK_MOUSE
NC score	0.085362 (rank : 365)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	446	Target Neighborhood Hits	1017	Shared Neighborhood Hits	131
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

ARHG2_MOUSE
NC score	0.085351 (rank : 366)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	446	Target Neighborhood Hits	120	Shared Neighborhood Hits	30
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

DVL1_HUMAN
NC score	0.085326 (rank : 367)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	446	Target Neighborhood Hits	158	Shared Neighborhood Hits	76
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

SNX18_MOUSE
NC score	0.085057 (rank : 368)	θ value	θ > 10 (rank : 798)
Query Neighborhood Hits	446	Target Neighborhood Hits	198	Shared Neighborhood Hits	80
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

BAT2_HUMAN
NC score	0.084978 (rank : 369)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	446	Target Neighborhood Hits	931	Shared Neighborhood Hits	112
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

LCK_HUMAN
NC score	0.084890 (rank : 370)	θ value	0.813845 (rank : 224)
Query Neighborhood Hits	446	Target Neighborhood Hits	987	Shared Neighborhood Hits	106
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

NCOA6_HUMAN
NC score	0.084681 (rank : 371)	θ value	0.365318 (rank : 194)
Query Neighborhood Hits	446	Target Neighborhood Hits	1202	Shared Neighborhood Hits	115
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

DDEF2_HUMAN
NC score	0.084547 (rank : 372)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	446	Target Neighborhood Hits	599	Shared Neighborhood Hits	127
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

MDC1_HUMAN
NC score	0.084469 (rank : 373)	θ value	1.38821 (rank : 256)
Query Neighborhood Hits	446	Target Neighborhood Hits	1446	Shared Neighborhood Hits	135
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

LYN_HUMAN
NC score	0.084426 (rank : 374)	θ value	θ > 10 (rank : 639)
Query Neighborhood Hits	446	Target Neighborhood Hits	1022	Shared Neighborhood Hits	127
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

DDEF2_MOUSE
NC score	0.084308 (rank : 375)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	446	Target Neighborhood Hits	625	Shared Neighborhood Hits	127
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

LCK_MOUSE
NC score	0.084252 (rank : 376)	θ value	2.36792 (rank : 296)
Query Neighborhood Hits	446	Target Neighborhood Hits	981	Shared Neighborhood Hits	105
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

DVL3_MOUSE
NC score	0.083944 (rank : 377)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	446	Target Neighborhood Hits	198	Shared Neighborhood Hits	74
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

STIM2_MOUSE
NC score	0.083725 (rank : 378)	θ value	0.0148317 (rank : 95)
Query Neighborhood Hits	446	Target Neighborhood Hits	403	Shared Neighborhood Hits	19
SwissProt Accessions	P83093, Q69ZI3, Q80VF4	Gene names	Stim2, Kiaa1482
Domain Architecture	No domain graphic available
Description	Stromal interaction molecule 2 precursor.

SASH1_MOUSE
NC score	0.083634 (rank : 379)	θ value	5.27518 (rank : 376)
Query Neighborhood Hits	446	Target Neighborhood Hits	263	Shared Neighborhood Hits	95
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

LYN_MOUSE
NC score	0.083593 (rank : 380)	θ value	θ > 10 (rank : 640)
Query Neighborhood Hits	446	Target Neighborhood Hits	1023	Shared Neighborhood Hits	124
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

SNX18_HUMAN
NC score	0.083491 (rank : 381)	θ value	θ > 10 (rank : 797)
Query Neighborhood Hits	446	Target Neighborhood Hits	207	Shared Neighborhood Hits	82
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

BLK_MOUSE
NC score	0.083254 (rank : 382)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	446	Target Neighborhood Hits	992	Shared Neighborhood Hits	109
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

DVL3_HUMAN
NC score	0.083246 (rank : 383)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	446	Target Neighborhood Hits	194	Shared Neighborhood Hits	71
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

EPHA5_MOUSE
NC score	0.082924 (rank : 384)	θ value	0.0193708 (rank : 97)
Query Neighborhood Hits	446	Target Neighborhood Hits	950	Shared Neighborhood Hits	70
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

MY18A_MOUSE
NC score	0.082665 (rank : 385)	θ value	0.000602161 (rank : 37)
Query Neighborhood Hits	446	Target Neighborhood Hits	1989	Shared Neighborhood Hits	154
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

EPHA6_MOUSE
NC score	0.082585 (rank : 386)	θ value	0.279714 (rank : 185)
Query Neighborhood Hits	446	Target Neighborhood Hits	946	Shared Neighborhood Hits	67
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

STIM2_HUMAN
NC score	0.082499 (rank : 387)	θ value	0.0193708 (rank : 101)
Query Neighborhood Hits	446	Target Neighborhood Hits	420	Shared Neighborhood Hits	21
SwissProt Accessions	Q9P246, Q96BF1, Q9BQH2, Q9H8R1	Gene names	STIM2, KIAA1482
Domain Architecture
Description	Stromal interaction molecule 2 precursor.

BLK_HUMAN
NC score	0.082496 (rank : 388)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	446	Target Neighborhood Hits	994	Shared Neighborhood Hits	106
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

RTP3_MOUSE
NC score	0.082437 (rank : 389)	θ value	0.47712 (rank : 204)
Query Neighborhood Hits	446	Target Neighborhood Hits	374	Shared Neighborhood Hits	52
SwissProt Accessions	Q5QGU6, Q8VDC2	Gene names	Rtp3, Tmem7
Domain Architecture	No domain graphic available
Description	Receptor-transporting protein 3 (Transmembrane protein 7).

ANKS1_MOUSE
NC score	0.082087 (rank : 390)	θ value	1.38821 (rank : 246)
Query Neighborhood Hits	446	Target Neighborhood Hits	453	Shared Neighborhood Hits	65
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

PTK6_MOUSE
NC score	0.081802 (rank : 391)	θ value	θ > 10 (rank : 737)
Query Neighborhood Hits	446	Target Neighborhood Hits	1026	Shared Neighborhood Hits	127
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

DVL2_MOUSE
NC score	0.081690 (rank : 392)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	446	Target Neighborhood Hits	233	Shared Neighborhood Hits	80
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

CSK_HUMAN
NC score	0.081649 (rank : 393)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	446	Target Neighborhood Hits	1009	Shared Neighborhood Hits	116
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

ARHGF_HUMAN
NC score	0.081550 (rank : 394)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	446	Target Neighborhood Hits	214	Shared Neighborhood Hits	55
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ES8L3_HUMAN
NC score	0.081510 (rank : 395)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	446	Target Neighborhood Hits	206	Shared Neighborhood Hits	85
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

EPHB4_HUMAN
NC score	0.081457 (rank : 396)	θ value	0.279714 (rank : 187)
Query Neighborhood Hits	446	Target Neighborhood Hits	1056	Shared Neighborhood Hits	73
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

MUC1_HUMAN
NC score	0.081420 (rank : 397)	θ value	0.0736092 (rank : 133)
Query Neighborhood Hits	446	Target Neighborhood Hits	975	Shared Neighborhood Hits	95
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

SELPL_MOUSE
NC score	0.081279 (rank : 398)	θ value	0.163984 (rank : 165)
Query Neighborhood Hits	446	Target Neighborhood Hits	588	Shared Neighborhood Hits	72
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

DVL1_MOUSE
NC score	0.081265 (rank : 399)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	446	Target Neighborhood Hits	146	Shared Neighborhood Hits	72
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

CSK_MOUSE
NC score	0.081227 (rank : 400)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	446	Target Neighborhood Hits	1009	Shared Neighborhood Hits	116
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

ES8L3_MOUSE
NC score	0.081213 (rank : 401)	θ value	θ > 10 (rank : 559)
Query Neighborhood Hits	446	Target Neighborhood Hits	168	Shared Neighborhood Hits	82
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

EPHB6_MOUSE
NC score	0.081009 (rank : 402)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	446	Target Neighborhood Hits	906	Shared Neighborhood Hits	74
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

EPHA7_MOUSE
NC score	0.080868 (rank : 403)	θ value	0.279714 (rank : 186)
Query Neighborhood Hits	446	Target Neighborhood Hits	1025	Shared Neighborhood Hits	71
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

DVL1L_HUMAN
NC score	0.080730 (rank : 404)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	446	Target Neighborhood Hits	146	Shared Neighborhood Hits	73
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

EPHB1_HUMAN
NC score	0.080726 (rank : 405)	θ value	0.813845 (rank : 223)
Query Neighborhood Hits	446	Target Neighborhood Hits	988	Shared Neighborhood Hits	72
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

SNX27_HUMAN
NC score	0.080717 (rank : 406)	θ value	0.163984 (rank : 167)
Query Neighborhood Hits	446	Target Neighborhood Hits	54	Shared Neighborhood Hits	13
SwissProt Accessions	Q96L92	Gene names	SNX27
Domain Architecture
Description	Sorting nexin-27.

EPHA7_HUMAN
NC score	0.080655 (rank : 407)	θ value	0.365318 (rank : 193)
Query Neighborhood Hits	446	Target Neighborhood Hits	1053	Shared Neighborhood Hits	75
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHB4_MOUSE
NC score	0.080306 (rank : 408)	θ value	0.62314 (rank : 211)
Query Neighborhood Hits	446	Target Neighborhood Hits	1013	Shared Neighborhood Hits	71
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

RHG26_HUMAN
NC score	0.080243 (rank : 409)	θ value	θ > 10 (rank : 748)
Query Neighborhood Hits	446	Target Neighborhood Hits	281	Shared Neighborhood Hits	87
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

PTK6_HUMAN
NC score	0.080236 (rank : 410)	θ value	θ > 10 (rank : 736)
Query Neighborhood Hits	446	Target Neighborhood Hits	1020	Shared Neighborhood Hits	126
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

SRRM2_HUMAN
NC score	0.080222 (rank : 411)	θ value	θ > 10 (rank : 813)
Query Neighborhood Hits	446	Target Neighborhood Hits	1296	Shared Neighborhood Hits	142
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

EPHB6_HUMAN
NC score	0.079857 (rank : 412)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	446	Target Neighborhood Hits	912	Shared Neighborhood Hits	70
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

REPS2_MOUSE
NC score	0.079809 (rank : 413)	θ value	0.365318 (rank : 197)
Query Neighborhood Hits	446	Target Neighborhood Hits	102	Shared Neighborhood Hits	21
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

GSCR1_HUMAN
NC score	0.079785 (rank : 414)	θ value	θ > 10 (rank : 589)
Query Neighborhood Hits	446	Target Neighborhood Hits	674	Shared Neighborhood Hits	92
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

ARHGA_HUMAN
NC score	0.079782 (rank : 415)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	446	Target Neighborhood Hits	187	Shared Neighborhood Hits	30
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

RGS3_HUMAN
NC score	0.079713 (rank : 416)	θ value	6.88961 (rank : 405)
Query Neighborhood Hits	446	Target Neighborhood Hits	1375	Shared Neighborhood Hits	147
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

LIPA4_HUMAN
NC score	0.079639 (rank : 417)	θ value	3.0926 (rank : 320)
Query Neighborhood Hits	446	Target Neighborhood Hits	56	Shared Neighborhood Hits	22
SwissProt Accessions	O75335, O94971	Gene names	PPFIA4, KIAA0897
Domain Architecture
Description	Liprin-alpha-4 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4) (PTPRF-interacting protein alpha-4).

EPHAA_HUMAN
NC score	0.079374 (rank : 418)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	446	Target Neighborhood Hits	960	Shared Neighborhood Hits	71
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

TEC_HUMAN
NC score	0.079239 (rank : 419)	θ value	θ > 10 (rank : 827)
Query Neighborhood Hits	446	Target Neighborhood Hits	1006	Shared Neighborhood Hits	122
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

SRRM1_MOUSE
NC score	0.079100 (rank : 420)	θ value	8.99809 (rank : 442)
Query Neighborhood Hits	446	Target Neighborhood Hits	966	Shared Neighborhood Hits	107
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

LMO7_HUMAN
NC score	0.078731 (rank : 421)	θ value	θ > 10 (rank : 632)
Query Neighborhood Hits	446	Target Neighborhood Hits	507	Shared Neighborhood Hits	71
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

MLTK_HUMAN
NC score	0.078643 (rank : 422)	θ value	0.00134147 (rank : 53)
Query Neighborhood Hits	446	Target Neighborhood Hits	911	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

SRGP2_MOUSE
NC score	0.078549 (rank : 423)	θ value	θ > 10 (rank : 809)
Query Neighborhood Hits	446	Target Neighborhood Hits	324	Shared Neighborhood Hits	102
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

TXK_MOUSE
NC score	0.078436 (rank : 424)	θ value	θ > 10 (rank : 839)
Query Neighborhood Hits	446	Target Neighborhood Hits	980	Shared Neighborhood Hits	114
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

PRRT3_MOUSE
NC score	0.078305 (rank : 425)	θ value	0.365318 (rank : 196)
Query Neighborhood Hits	446	Target Neighborhood Hits	162	Shared Neighborhood Hits	25
SwissProt Accessions	Q6PE13	Gene names	Prrt3
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

MLTK_MOUSE
NC score	0.078271 (rank : 426)	θ value	0.00102713 (rank : 47)
Query Neighborhood Hits	446	Target Neighborhood Hits	874	Shared Neighborhood Hits	63
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

TARSH_HUMAN
NC score	0.078094 (rank : 427)	θ value	2.36792 (rank : 308)
Query Neighborhood Hits	446	Target Neighborhood Hits	768	Shared Neighborhood Hits	92
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

LCP2_HUMAN
NC score	0.077857 (rank : 428)	θ value	θ > 10 (rank : 625)
Query Neighborhood Hits	446	Target Neighborhood Hits	531	Shared Neighborhood Hits	77
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

SRRM2_MOUSE
NC score	0.077705 (rank : 429)	θ value	5.27518 (rank : 380)
Query Neighborhood Hits	446	Target Neighborhood Hits	1470	Shared Neighborhood Hits	153
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

SRGP2_HUMAN
NC score	0.077603 (rank : 430)	θ value	θ > 10 (rank : 808)
Query Neighborhood Hits	446	Target Neighborhood Hits	331	Shared Neighborhood Hits	101
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SHLB1_HUMAN
NC score	0.077545 (rank : 431)	θ value	θ > 10 (rank : 783)
Query Neighborhood Hits	446	Target Neighborhood Hits	96	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

TXK_HUMAN
NC score	0.077478 (rank : 432)	θ value	θ > 10 (rank : 838)
Query Neighborhood Hits	446	Target Neighborhood Hits	971	Shared Neighborhood Hits	107
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

FNBP2_HUMAN
NC score	0.077392 (rank : 433)	θ value	θ > 10 (rank : 580)
Query Neighborhood Hits	446	Target Neighborhood Hits	432	Shared Neighborhood Hits	101
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

MY18A_HUMAN
NC score	0.076707 (rank : 434)	θ value	0.00509761 (rank : 77)
Query Neighborhood Hits	446	Target Neighborhood Hits	1929	Shared Neighborhood Hits	148
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

TEX14_HUMAN
NC score	0.076644 (rank : 435)	θ value	θ > 10 (rank : 829)
Query Neighborhood Hits	446	Target Neighborhood Hits	1103	Shared Neighborhood Hits	87
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

SHLB1_MOUSE
NC score	0.076593 (rank : 436)	θ value	θ > 10 (rank : 784)
Query Neighborhood Hits	446	Target Neighborhood Hits	101	Shared Neighborhood Hits	51
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

MDC1_MOUSE
NC score	0.076557 (rank : 437)	θ value	6.88961 (rank : 402)
Query Neighborhood Hits	446	Target Neighborhood Hits	998	Shared Neighborhood Hits	104
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

BAT2_MOUSE
NC score	0.076445 (rank : 438)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	446	Target Neighborhood Hits	947	Shared Neighborhood Hits	115
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

SLAP2_MOUSE
NC score	0.076198 (rank : 439)	θ value	θ > 10 (rank : 792)
Query Neighborhood Hits	446	Target Neighborhood Hits	136	Shared Neighborhood Hits	35
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

NOLC1_HUMAN
NC score	0.076152 (rank : 440)	θ value	1.81305 (rank : 281)
Query Neighborhood Hits	446	Target Neighborhood Hits	452	Shared Neighborhood Hits	59
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

EPHA2_MOUSE
NC score	0.076085 (rank : 441)	θ value	3.0926 (rank : 315)
Query Neighborhood Hits	446	Target Neighborhood Hits	1020	Shared Neighborhood Hits	70
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

TEC_MOUSE
NC score	0.075962 (rank : 442)	θ value	θ > 10 (rank : 828)
Query Neighborhood Hits	446	Target Neighborhood Hits	1006	Shared Neighborhood Hits	122
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

SRGP1_HUMAN
NC score	0.075838 (rank : 443)	θ value	θ > 10 (rank : 807)
Query Neighborhood Hits	446	Target Neighborhood Hits	390	Shared Neighborhood Hits	101
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

EPHA8_MOUSE
NC score	0.075636 (rank : 444)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	446	Target Neighborhood Hits	969	Shared Neighborhood Hits	72
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

MUC7_HUMAN
NC score	0.075634 (rank : 445)	θ value	θ > 10 (rank : 667)
Query Neighborhood Hits	446	Target Neighborhood Hits	538	Shared Neighborhood Hits	84
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

SPTA2_HUMAN
NC score	0.075534 (rank : 446)	θ value	θ > 10 (rank : 805)
Query Neighborhood Hits	446	Target Neighborhood Hits	888	Shared Neighborhood Hits	119
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

EPHA8_HUMAN
NC score	0.075107 (rank : 447)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	446	Target Neighborhood Hits	956	Shared Neighborhood Hits	68
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

DAPP1_HUMAN
NC score	0.075002 (rank : 448)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	446	Target Neighborhood Hits	227	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

EPHA2_HUMAN
NC score	0.074881 (rank : 449)	θ value	6.88961 (rank : 395)
Query Neighborhood Hits	446	Target Neighborhood Hits	1021	Shared Neighborhood Hits	70
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

ARHGA_MOUSE
NC score	0.074805 (rank : 450)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	446	Target Neighborhood Hits	125	Shared Neighborhood Hits	26
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

EPHA1_MOUSE
NC score	0.074725 (rank : 451)	θ value	8.99809 (rank : 424)
Query Neighborhood Hits	446	Target Neighborhood Hits	958	Shared Neighborhood Hits	68
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

OGFR_HUMAN
NC score	0.074607 (rank : 452)	θ value	0.47712 (rank : 200)
Query Neighborhood Hits	446	Target Neighborhood Hits	1582	Shared Neighborhood Hits	118
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

SLAP2_HUMAN
NC score	0.074486 (rank : 453)	θ value	θ > 10 (rank : 791)
Query Neighborhood Hits	446	Target Neighborhood Hits	139	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

WASIP_HUMAN
NC score	0.074434 (rank : 454)	θ value	θ > 10 (rank : 844)
Query Neighborhood Hits	446	Target Neighborhood Hits	458	Shared Neighborhood Hits	79
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

DAPP1_MOUSE
NC score	0.074380 (rank : 455)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	446	Target Neighborhood Hits	225	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

EPHA4_MOUSE
NC score	0.074357 (rank : 456)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	446	Target Neighborhood Hits	982	Shared Neighborhood Hits	70
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

AMPH_MOUSE
NC score	0.074181 (rank : 457)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	446	Target Neighborhood Hits	291	Shared Neighborhood Hits	72
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

TCOF_HUMAN
NC score	0.074178 (rank : 458)	θ value	0.47712 (rank : 206)
Query Neighborhood Hits	446	Target Neighborhood Hits	543	Shared Neighborhood Hits	68
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

EPHA4_HUMAN
NC score	0.073977 (rank : 459)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	446	Target Neighborhood Hits	975	Shared Neighborhood Hits	69
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

SIPA1_HUMAN
NC score	0.073814 (rank : 460)	θ value	θ > 10 (rank : 787)
Query Neighborhood Hits	446	Target Neighborhood Hits	250	Shared Neighborhood Hits	39
SwissProt Accessions	Q96FS4, O14518, O60484, O60618	Gene names	SIPA1, SPA1
Domain Architecture
Description	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase- activating protein Spa-1) (p130 SPA-1).

NOS1_MOUSE
NC score	0.073526 (rank : 461)	θ value	θ > 10 (rank : 679)
Query Neighborhood Hits	446	Target Neighborhood Hits	155	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

RUSC1_HUMAN
NC score	0.073302 (rank : 462)	θ value	θ > 10 (rank : 763)
Query Neighborhood Hits	446	Target Neighborhood Hits	226	Shared Neighborhood Hits	89
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

BIN1_MOUSE
NC score	0.073241 (rank : 463)	θ value	1.81305 (rank : 269)
Query Neighborhood Hits	446	Target Neighborhood Hits	283	Shared Neighborhood Hits	69
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

EPHA1_HUMAN
NC score	0.073168 (rank : 464)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	446	Target Neighborhood Hits	997	Shared Neighborhood Hits	69
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

PDZD8_HUMAN
NC score	0.073047 (rank : 465)	θ value	θ > 10 (rank : 714)
Query Neighborhood Hits	446	Target Neighborhood Hits	185	Shared Neighborhood Hits	55
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

SON_HUMAN
NC score	0.072951 (rank : 466)	θ value	1.81305 (rank : 287)
Query Neighborhood Hits	446	Target Neighborhood Hits	1568	Shared Neighborhood Hits	128
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

RIMS1_HUMAN
NC score	0.072931 (rank : 467)	θ value	θ > 10 (rank : 751)
Query Neighborhood Hits	446	Target Neighborhood Hits	437	Shared Neighborhood Hits	110
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

WIRE_MOUSE
NC score	0.072909 (rank : 468)	θ value	θ > 10 (rank : 846)
Query Neighborhood Hits	446	Target Neighborhood Hits	310	Shared Neighborhood Hits	62
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

FGD4_MOUSE
NC score	0.072660 (rank : 469)	θ value	θ > 10 (rank : 576)
Query Neighborhood Hits	446	Target Neighborhood Hits	227	Shared Neighborhood Hits	33
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

SLY_MOUSE
NC score	0.072564 (rank : 470)	θ value	θ > 10 (rank : 794)
Query Neighborhood Hits	446	Target Neighborhood Hits	108	Shared Neighborhood Hits	63
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

FGD4_HUMAN
NC score	0.072523 (rank : 471)	θ value	θ > 10 (rank : 575)
Query Neighborhood Hits	446	Target Neighborhood Hits	219	Shared Neighborhood Hits	32
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

TEX14_MOUSE
NC score	0.072163 (rank : 472)	θ value	θ > 10 (rank : 830)
Query Neighborhood Hits	446	Target Neighborhood Hits	1333	Shared Neighborhood Hits	90
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

ITK_HUMAN
NC score	0.072141 (rank : 473)	θ value	θ > 10 (rank : 609)
Query Neighborhood Hits	446	Target Neighborhood Hits	1016	Shared Neighborhood Hits	115
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

RAPH1_HUMAN
NC score	0.071804 (rank : 474)	θ value	θ > 10 (rank : 741)
Query Neighborhood Hits	446	Target Neighborhood Hits	593	Shared Neighborhood Hits	93
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

FGD1_MOUSE
NC score	0.071407 (rank : 475)	θ value	θ > 10 (rank : 570)
Query Neighborhood Hits	446	Target Neighborhood Hits	387	Shared Neighborhood Hits	69
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

SLY_HUMAN
NC score	0.071267 (rank : 476)	θ value	θ > 10 (rank : 793)
Query Neighborhood Hits	446	Target Neighborhood Hits	81	Shared Neighborhood Hits	57
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

LRRC7_HUMAN
NC score	0.071219 (rank : 477)	θ value	θ > 10 (rank : 633)
Query Neighborhood Hits	446	Target Neighborhood Hits	423	Shared Neighborhood Hits	87
SwissProt Accessions	Q96NW7, Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2	Gene names	LRRC7, KIAA1365, LAP1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

SNX9_HUMAN
NC score	0.071159 (rank : 478)	θ value	θ > 10 (rank : 799)
Query Neighborhood Hits	446	Target Neighborhood Hits	148	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

FGD1_HUMAN
NC score	0.071070 (rank : 479)	θ value	θ > 10 (rank : 569)
Query Neighborhood Hits	446	Target Neighborhood Hits	367	Shared Neighborhood Hits	71
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

LRRC7_MOUSE
NC score	0.070779 (rank : 480)	θ value	θ > 10 (rank : 634)
Query Neighborhood Hits	446	Target Neighborhood Hits	416	Shared Neighborhood Hits	89
SwissProt Accessions	Q80TE7	Gene names	Lrrc7, Kiaa1365, Lap1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

ILK_MOUSE
NC score	0.070772 (rank : 481)	θ value	θ > 10 (rank : 601)
Query Neighborhood Hits	446	Target Neighborhood Hits	858	Shared Neighborhood Hits	59
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

AMPH_HUMAN
NC score	0.070716 (rank : 482)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	446	Target Neighborhood Hits	455	Shared Neighborhood Hits	91
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

BSN_MOUSE
NC score	0.070672 (rank : 483)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	446	Target Neighborhood Hits	2057	Shared Neighborhood Hits	167
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

EPHA3_MOUSE
NC score	0.070606 (rank : 484)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	446	Target Neighborhood Hits	1009	Shared Neighborhood Hits	62
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

SLAP1_HUMAN
NC score	0.070555 (rank : 485)	θ value	θ > 10 (rank : 789)
Query Neighborhood Hits	446	Target Neighborhood Hits	113	Shared Neighborhood Hits	29
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

EPHA3_HUMAN
NC score	0.070487 (rank : 486)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	446	Target Neighborhood Hits	1005	Shared Neighborhood Hits	62
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

WIRE_HUMAN
NC score	0.070425 (rank : 487)	θ value	8.99809 (rank : 445)
Query Neighborhood Hits	446	Target Neighborhood Hits	329	Shared Neighborhood Hits	65
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

ILK2_HUMAN
NC score	0.070365 (rank : 488)	θ value	θ > 10 (rank : 600)
Query Neighborhood Hits	446	Target Neighborhood Hits	848	Shared Neighborhood Hits	58
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

SRRM1_HUMAN
NC score	0.070024 (rank : 489)	θ value	θ > 10 (rank : 812)
Query Neighborhood Hits	446	Target Neighborhood Hits	690	Shared Neighborhood Hits	96
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

ILK1_HUMAN
NC score	0.069950 (rank : 490)	θ value	θ > 10 (rank : 599)
Query Neighborhood Hits	446	Target Neighborhood Hits	857	Shared Neighborhood Hits	59
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ITK_MOUSE
NC score	0.069762 (rank : 491)	θ value	θ > 10 (rank : 610)
Query Neighborhood Hits	446	Target Neighborhood Hits	985	Shared Neighborhood Hits	105
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

SLAP1_MOUSE
NC score	0.069624 (rank : 492)	θ value	θ > 10 (rank : 790)
Query Neighborhood Hits	446	Target Neighborhood Hits	117	Shared Neighborhood Hits	29
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

RUSC1_MOUSE
NC score	0.069582 (rank : 493)	θ value	θ > 10 (rank : 764)
Query Neighborhood Hits	446	Target Neighborhood Hits	206	Shared Neighborhood Hits	87
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

MATK_MOUSE
NC score	0.069504 (rank : 494)	θ value	θ > 10 (rank : 647)
Query Neighborhood Hits	446	Target Neighborhood Hits	952	Shared Neighborhood Hits	85
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

PCLO_HUMAN
NC score	0.069162 (rank : 495)	θ value	3.0926 (rank : 326)
Query Neighborhood Hits	446	Target Neighborhood Hits	2046	Shared Neighborhood Hits	165
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

SRMS_MOUSE
NC score	0.069159 (rank : 496)	θ value	θ > 10 (rank : 811)
Query Neighborhood Hits	446	Target Neighborhood Hits	964	Shared Neighborhood Hits	90
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

BSN_HUMAN
NC score	0.069134 (rank : 497)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	446	Target Neighborhood Hits	1537	Shared Neighborhood Hits	144
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

MATK_HUMAN
NC score	0.068821 (rank : 498)	θ value	θ > 10 (rank : 646)
Query Neighborhood Hits	446	Target Neighborhood Hits	954	Shared Neighborhood Hits	80
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

BIN1_HUMAN
NC score	0.068639 (rank : 499)	θ value	3.0926 (rank : 310)
Query Neighborhood Hits	446	Target Neighborhood Hits	335	Shared Neighborhood Hits	75
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

CSKP_HUMAN
NC score	0.068580 (rank : 500)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	446	Target Neighborhood Hits	1022	Shared Neighborhood Hits	174
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

LCP2_MOUSE
NC score	0.068448 (rank : 501)	θ value	5.27518 (rank : 363)
Query Neighborhood Hits	446	Target Neighborhood Hits	177	Shared Neighborhood Hits	44
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

SRMS_HUMAN
NC score	0.068424 (rank : 502)	θ value	θ > 10 (rank : 810)
Query Neighborhood Hits	446	Target Neighborhood Hits	946	Shared Neighborhood Hits	82
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

LAP2_HUMAN
NC score	0.068330 (rank : 503)	θ value	θ > 10 (rank : 620)
Query Neighborhood Hits	446	Target Neighborhood Hits	499	Shared Neighborhood Hits	89
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

ACK1_HUMAN
NC score	0.068226 (rank : 504)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	446	Target Neighborhood Hits	1140	Shared Neighborhood Hits	131
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

FGD3_MOUSE
NC score	0.068190 (rank : 505)	θ value	θ > 10 (rank : 574)
Query Neighborhood Hits	446	Target Neighborhood Hits	257	Shared Neighborhood Hits	31
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

PRP1_HUMAN
NC score	0.067953 (rank : 506)	θ value	θ > 10 (rank : 734)
Query Neighborhood Hits	446	Target Neighborhood Hits	385	Shared Neighborhood Hits	67
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

GNRP_MOUSE
NC score	0.067524 (rank : 507)	θ value	θ > 10 (rank : 587)
Query Neighborhood Hits	446	Target Neighborhood Hits	191	Shared Neighborhood Hits	30
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GIPC1_MOUSE
NC score	0.067434 (rank : 508)	θ value	θ > 10 (rank : 584)
Query Neighborhood Hits	446	Target Neighborhood Hits	92	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Z0G0	Gene names	Gipc1, Gipc, Rgs19ip1, Semcap1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Synectin) (SemaF cytoplasmic domain-associated protein 1) (SEMCAP-1).

ACK1_MOUSE
NC score	0.067090 (rank : 509)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	446	Target Neighborhood Hits	1080	Shared Neighborhood Hits	133
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

WASIP_MOUSE
NC score	0.066922 (rank : 510)	θ value	θ > 10 (rank : 845)
Query Neighborhood Hits	446	Target Neighborhood Hits	392	Shared Neighborhood Hits	70
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

CSKP_MOUSE
NC score	0.066676 (rank : 511)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	446	Target Neighborhood Hits	1027	Shared Neighborhood Hits	177
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

PRG4_HUMAN
NC score	0.066592 (rank : 512)	θ value	θ > 10 (rank : 732)
Query Neighborhood Hits	446	Target Neighborhood Hits	764	Shared Neighborhood Hits	94
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

ANR11_HUMAN
NC score	0.066555 (rank : 513)	θ value	0.163984 (rank : 159)
Query Neighborhood Hits	446	Target Neighborhood Hits	1289	Shared Neighborhood Hits	104
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

NU214_HUMAN
NC score	0.066014 (rank : 514)	θ value	θ > 10 (rank : 687)
Query Neighborhood Hits	446	Target Neighborhood Hits	657	Shared Neighborhood Hits	78
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

SHLB2_MOUSE
NC score	0.065632 (rank : 515)	θ value	θ > 10 (rank : 786)
Query Neighborhood Hits	446	Target Neighborhood Hits	88	Shared Neighborhood Hits	45
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

ANKK1_HUMAN
NC score	0.065398 (rank : 516)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	446	Target Neighborhood Hits	1075	Shared Neighborhood Hits	66
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

SHLB2_HUMAN
NC score	0.065353 (rank : 517)	θ value	θ > 10 (rank : 785)
Query Neighborhood Hits	446	Target Neighborhood Hits	86	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

ZAP70_MOUSE
NC score	0.065127 (rank : 518)	θ value	θ > 10 (rank : 849)
Query Neighborhood Hits	446	Target Neighborhood Hits	905	Shared Neighborhood Hits	72
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_HUMAN
NC score	0.065090 (rank : 519)	θ value	θ > 10 (rank : 848)
Query Neighborhood Hits	446	Target Neighborhood Hits	893	Shared Neighborhood Hits	73
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

SHC3_MOUSE
NC score	0.064911 (rank : 520)	θ value	θ > 10 (rank : 778)
Query Neighborhood Hits	446	Target Neighborhood Hits	151	Shared Neighborhood Hits	45
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

ANKK1_MOUSE
NC score	0.064809 (rank : 521)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	446	Target Neighborhood Hits	1072	Shared Neighborhood Hits	66
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

FGD3_HUMAN
NC score	0.064781 (rank : 522)	θ value	θ > 10 (rank : 573)
Query Neighborhood Hits	446	Target Neighborhood Hits	249	Shared Neighborhood Hits	34
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

NFH_MOUSE
NC score	0.064626 (rank : 523)	θ value	4.03905 (rank : 345)
Query Neighborhood Hits	446	Target Neighborhood Hits	2247	Shared Neighborhood Hits	165
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

P85A_MOUSE
NC score	0.064622 (rank : 524)	θ value	θ > 10 (rank : 691)
Query Neighborhood Hits	446	Target Neighborhood Hits	435	Shared Neighborhood Hits	79
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

TAF4_HUMAN
NC score	0.064361 (rank : 525)	θ value	6.88961 (rank : 412)
Query Neighborhood Hits	446	Target Neighborhood Hits	687	Shared Neighborhood Hits	77
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

TXND2_HUMAN
NC score	0.064293 (rank : 526)	θ value	0.0961366 (rank : 151)
Query Neighborhood Hits	446	Target Neighborhood Hits	793	Shared Neighborhood Hits	73
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

KSYK_MOUSE
NC score	0.064190 (rank : 527)	θ value	θ > 10 (rank : 619)
Query Neighborhood Hits	446	Target Neighborhood Hits	944	Shared Neighborhood Hits	77
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

FGD2_MOUSE
NC score	0.064184 (rank : 528)	θ value	θ > 10 (rank : 572)
Query Neighborhood Hits	446	Target Neighborhood Hits	163	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

SPTA1_MOUSE
NC score	0.064177 (rank : 529)	θ value	θ > 10 (rank : 804)
Query Neighborhood Hits	446	Target Neighborhood Hits	675	Shared Neighborhood Hits	95
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

PRP2_MOUSE
NC score	0.064117 (rank : 530)	θ value	θ > 10 (rank : 735)
Query Neighborhood Hits	446	Target Neighborhood Hits	347	Shared Neighborhood Hits	60
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

P85B_HUMAN
NC score	0.064060 (rank : 531)	θ value	θ > 10 (rank : 692)
Query Neighborhood Hits	446	Target Neighborhood Hits	543	Shared Neighborhood Hits	70
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SH22A_MOUSE
NC score	0.063769 (rank : 532)	θ value	0.813845 (rank : 230)
Query Neighborhood Hits	446	Target Neighborhood Hits	179	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

FGD2_HUMAN
NC score	0.063568 (rank : 533)	θ value	θ > 10 (rank : 571)
Query Neighborhood Hits	446	Target Neighborhood Hits	151	Shared Neighborhood Hits	27
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

KSYK_HUMAN
NC score	0.063563 (rank : 534)	θ value	θ > 10 (rank : 618)
Query Neighborhood Hits	446	Target Neighborhood Hits	901	Shared Neighborhood Hits	71
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

TARA_HUMAN
NC score	0.063490 (rank : 535)	θ value	2.36792 (rank : 307)
Query Neighborhood Hits	446	Target Neighborhood Hits	1626	Shared Neighborhood Hits	127
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

FER_HUMAN
NC score	0.063455 (rank : 536)	θ value	θ > 10 (rank : 566)
Query Neighborhood Hits	446	Target Neighborhood Hits	1278	Shared Neighborhood Hits	85
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

TNI3K_MOUSE
NC score	0.063449 (rank : 537)	θ value	θ > 10 (rank : 834)
Query Neighborhood Hits	446	Target Neighborhood Hits	1079	Shared Neighborhood Hits	66
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

RIPK4_HUMAN
NC score	0.063328 (rank : 538)	θ value	θ > 10 (rank : 755)
Query Neighborhood Hits	446	Target Neighborhood Hits	1094	Shared Neighborhood Hits	67
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

GNRP_HUMAN
NC score	0.063217 (rank : 539)	θ value	θ > 10 (rank : 586)
Query Neighborhood Hits	446	Target Neighborhood Hits	239	Shared Neighborhood Hits	29
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

SIPA1_MOUSE
NC score	0.063202 (rank : 540)	θ value	θ > 10 (rank : 788)
Query Neighborhood Hits	446	Target Neighborhood Hits	158	Shared Neighborhood Hits	24
SwissProt Accessions	P46062, P70204	Gene names	Sipa1, Spa-1, Spa1
Domain Architecture
Description	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase- activating protein Spa-1).

LIPA3_MOUSE
NC score	0.062992 (rank : 541)	θ value	1.81305 (rank : 279)
Query Neighborhood Hits	446	Target Neighborhood Hits	636	Shared Neighborhood Hits	45
SwissProt Accessions	P60469	Gene names	Ppfia3
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

GIPC1_HUMAN
NC score	0.062954 (rank : 542)	θ value	θ > 10 (rank : 583)
Query Neighborhood Hits	446	Target Neighborhood Hits	91	Shared Neighborhood Hits	60
SwissProt Accessions	O14908, Q9BTC9	Gene names	GIPC1, C19orf3, GIPC, RGS19IP1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Tax interaction protein 2) (TIP-2).

LAP2_MOUSE
NC score	0.062895 (rank : 543)	θ value	θ > 10 (rank : 621)
Query Neighborhood Hits	446	Target Neighborhood Hits	482	Shared Neighborhood Hits	83
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

TNI3K_HUMAN
NC score	0.062753 (rank : 544)	θ value	θ > 10 (rank : 833)
Query Neighborhood Hits	446	Target Neighborhood Hits	1084	Shared Neighborhood Hits	66
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

SHC3_HUMAN
NC score	0.062591 (rank : 545)	θ value	θ > 10 (rank : 777)
Query Neighborhood Hits	446	Target Neighborhood Hits	155	Shared Neighborhood Hits	46
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHE_MOUSE
NC score	0.062108 (rank : 546)	θ value	θ > 10 (rank : 782)
Query Neighborhood Hits	446	Target Neighborhood Hits	169	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

MLL3_HUMAN
NC score	0.062072 (rank : 547)	θ value	0.0563607 (rank : 122)
Query Neighborhood Hits	446	Target Neighborhood Hits	1644	Shared Neighborhood Hits	118
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

ANK2_HUMAN
NC score	0.062017 (rank : 548)	θ value	0.62314 (rank : 207)
Query Neighborhood Hits	446	Target Neighborhood Hits	1615	Shared Neighborhood Hits	135
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

IRAK3_HUMAN
NC score	0.061971 (rank : 549)	θ value	θ > 10 (rank : 607)
Query Neighborhood Hits	446	Target Neighborhood Hits	644	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

ES8L2_MOUSE
NC score	0.061915 (rank : 550)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	446	Target Neighborhood Hits	169	Shared Neighborhood Hits	72
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

SHC1_HUMAN
NC score	0.061876 (rank : 551)	θ value	θ > 10 (rank : 773)
Query Neighborhood Hits	446	Target Neighborhood Hits	170	Shared Neighborhood Hits	50
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

BCL9_HUMAN
NC score	0.061859 (rank : 552)	θ value	1.38821 (rank : 247)
Query Neighborhood Hits	446	Target Neighborhood Hits	1008	Shared Neighborhood Hits	102
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

K1543_MOUSE
NC score	0.061762 (rank : 553)	θ value	8.99809 (rank : 429)
Query Neighborhood Hits	446	Target Neighborhood Hits	497	Shared Neighborhood Hits	76
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

P85A_HUMAN
NC score	0.061450 (rank : 554)	θ value	θ > 10 (rank : 690)
Query Neighborhood Hits	446	Target Neighborhood Hits	479	Shared Neighborhood Hits	72
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SPN90_HUMAN
NC score	0.061335 (rank : 555)	θ value	θ > 10 (rank : 801)
Query Neighborhood Hits	446	Target Neighborhood Hits	157	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

BMX_MOUSE
NC score	0.061279 (rank : 556)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	446	Target Neighborhood Hits	912	Shared Neighborhood Hits	70
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

ERBB2_HUMAN
NC score	0.061133 (rank : 557)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	446	Target Neighborhood Hits	1073	Shared Neighborhood Hits	68
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

SAPS1_HUMAN
NC score	0.061081 (rank : 558)	θ value	0.21417 (rank : 177)
Query Neighborhood Hits	446	Target Neighborhood Hits	704	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

P85B_MOUSE
NC score	0.061058 (rank : 559)	θ value	θ > 10 (rank : 693)
Query Neighborhood Hits	446	Target Neighborhood Hits	519	Shared Neighborhood Hits	59
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

TNK1_MOUSE
NC score	0.060863 (rank : 560)	θ value	θ > 10 (rank : 836)
Query Neighborhood Hits	446	Target Neighborhood Hits	806	Shared Neighborhood Hits	61
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

ES8L2_HUMAN
NC score	0.060724 (rank : 561)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	446	Target Neighborhood Hits	193	Shared Neighborhood Hits	74
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

BMX_HUMAN
NC score	0.060564 (rank : 562)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	446	Target Neighborhood Hits	942	Shared Neighborhood Hits	72
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

IRAK3_MOUSE
NC score	0.060518 (rank : 563)	θ value	θ > 10 (rank : 608)
Query Neighborhood Hits	446	Target Neighborhood Hits	628	Shared Neighborhood Hits	49
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

SNX9_MOUSE
NC score	0.060335 (rank : 564)	θ value	θ > 10 (rank : 800)
Query Neighborhood Hits	446	Target Neighborhood Hits	141	Shared Neighborhood Hits	62
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SHC1_MOUSE
NC score	0.060201 (rank : 565)	θ value	θ > 10 (rank : 774)
Query Neighborhood Hits	446	Target Neighborhood Hits	180	Shared Neighborhood Hits	48
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

STS2_HUMAN
NC score	0.060177 (rank : 566)	θ value	θ > 10 (rank : 818)
Query Neighborhood Hits	446	Target Neighborhood Hits	108	Shared Neighborhood Hits	55
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

TNK1_HUMAN
NC score	0.059900 (rank : 567)	θ value	θ > 10 (rank : 835)
Query Neighborhood Hits	446	Target Neighborhood Hits	815	Shared Neighborhood Hits	60
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

CN155_HUMAN
NC score	0.059791 (rank : 568)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	446	Target Neighborhood Hits	385	Shared Neighborhood Hits	71
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

EPS8_HUMAN
NC score	0.059678 (rank : 569)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	446	Target Neighborhood Hits	151	Shared Neighborhood Hits	77
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

LTK_MOUSE
NC score	0.059490 (rank : 570)	θ value	θ > 10 (rank : 638)
Query Neighborhood Hits	446	Target Neighborhood Hits	770	Shared Neighborhood Hits	50
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

RASA1_HUMAN
NC score	0.059436 (rank : 571)	θ value	θ > 10 (rank : 742)
Query Neighborhood Hits	446	Target Neighborhood Hits	258	Shared Neighborhood Hits	49
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

PRB4S_HUMAN
NC score	0.059314 (rank : 572)	θ value	θ > 10 (rank : 730)
Query Neighborhood Hits	446	Target Neighborhood Hits	330	Shared Neighborhood Hits	57
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

SPTA1_HUMAN
NC score	0.059025 (rank : 573)	θ value	θ > 10 (rank : 803)
Query Neighborhood Hits	446	Target Neighborhood Hits	748	Shared Neighborhood Hits	102
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

TRIO_HUMAN
NC score	0.058994 (rank : 574)	θ value	θ > 10 (rank : 837)
Query Neighborhood Hits	446	Target Neighborhood Hits	1580	Shared Neighborhood Hits	129
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

ERBB2_MOUSE
NC score	0.058958 (rank : 575)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	446	Target Neighborhood Hits	918	Shared Neighborhood Hits	57
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

LIMK1_HUMAN
NC score	0.058619 (rank : 576)	θ value	θ > 10 (rank : 628)
Query Neighborhood Hits	446	Target Neighborhood Hits	1005	Shared Neighborhood Hits	103
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

MLKL_HUMAN
NC score	0.058570 (rank : 577)	θ value	θ > 10 (rank : 654)
Query Neighborhood Hits	446	Target Neighborhood Hits	600	Shared Neighborhood Hits	50
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

DUET_HUMAN
NC score	0.058507 (rank : 578)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	446	Target Neighborhood Hits	1220	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

EGFR_HUMAN
NC score	0.058351 (rank : 579)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	446	Target Neighborhood Hits	939	Shared Neighborhood Hits	52
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

FES_HUMAN
NC score	0.058346 (rank : 580)	θ value	θ > 10 (rank : 567)
Query Neighborhood Hits	446	Target Neighborhood Hits	978	Shared Neighborhood Hits	66
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

LIMK1_MOUSE
NC score	0.058321 (rank : 581)	θ value	θ > 10 (rank : 629)
Query Neighborhood Hits	446	Target Neighborhood Hits	1008	Shared Neighborhood Hits	103
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

RYK_HUMAN
NC score	0.058291 (rank : 582)	θ value	θ > 10 (rank : 766)
Query Neighborhood Hits	446	Target Neighborhood Hits	701	Shared Neighborhood Hits	49
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

LIMK2_MOUSE
NC score	0.058172 (rank : 583)	θ value	θ > 10 (rank : 631)
Query Neighborhood Hits	446	Target Neighborhood Hits	998	Shared Neighborhood Hits	97
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIPA3_HUMAN
NC score	0.058172 (rank : 584)	θ value	1.81305 (rank : 278)
Query Neighborhood Hits	446	Target Neighborhood Hits	828	Shared Neighborhood Hits	50
SwissProt Accessions	O75145, Q9H8B5, Q9UEW4	Gene names	PPFIA3, KIAA0654
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

DDR1_HUMAN
NC score	0.058154 (rank : 585)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	446	Target Neighborhood Hits	819	Shared Neighborhood Hits	52
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

RYK_MOUSE
NC score	0.058120 (rank : 586)	θ value	θ > 10 (rank : 767)
Query Neighborhood Hits	446	Target Neighborhood Hits	715	Shared Neighborhood Hits	49
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

LTK_HUMAN
NC score	0.058054 (rank : 587)	θ value	θ > 10 (rank : 637)
Query Neighborhood Hits	446	Target Neighborhood Hits	774	Shared Neighborhood Hits	50
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

TCOF_MOUSE
NC score	0.058045 (rank : 588)	θ value	θ > 10 (rank : 826)
Query Neighborhood Hits	446	Target Neighborhood Hits	471	Shared Neighborhood Hits	60
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

SON_MOUSE
NC score	0.057935 (rank : 589)	θ value	4.03905 (rank : 352)
Query Neighborhood Hits	446	Target Neighborhood Hits	957	Shared Neighborhood Hits	81
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

PRB3_HUMAN
NC score	0.057653 (rank : 590)	θ value	θ > 10 (rank : 729)
Query Neighborhood Hits	446	Target Neighborhood Hits	318	Shared Neighborhood Hits	54
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

DDR1_MOUSE
NC score	0.057623 (rank : 591)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	446	Target Neighborhood Hits	818	Shared Neighborhood Hits	52
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

EGFR_MOUSE
NC score	0.057603 (rank : 592)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	446	Target Neighborhood Hits	927	Shared Neighborhood Hits	52
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

APS_HUMAN
NC score	0.057571 (rank : 593)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	446	Target Neighborhood Hits	162	Shared Neighborhood Hits	47
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

FES_MOUSE
NC score	0.057561 (rank : 594)	θ value	θ > 10 (rank : 568)
Query Neighborhood Hits	446	Target Neighborhood Hits	980	Shared Neighborhood Hits	66
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

NCOA6_MOUSE
NC score	0.057548 (rank : 595)	θ value	4.03905 (rank : 344)
Query Neighborhood Hits	446	Target Neighborhood Hits	1076	Shared Neighborhood Hits	99
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

DDR2_HUMAN
NC score	0.057548 (rank : 596)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	446	Target Neighborhood Hits	818	Shared Neighborhood Hits	52
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

PHC1_HUMAN
NC score	0.057517 (rank : 597)	θ value	1.38821 (rank : 259)
Query Neighborhood Hits	446	Target Neighborhood Hits	227	Shared Neighborhood Hits	38
SwissProt Accessions	P78364, Q8WVM3, Q9BU63	Gene names	PHC1, EDR1, PH1
Domain Architecture
Description	Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1).

ALK_MOUSE
NC score	0.057488 (rank : 598)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	446	Target Neighborhood Hits	811	Shared Neighborhood Hits	59
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

DDR2_MOUSE
NC score	0.057456 (rank : 599)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	446	Target Neighborhood Hits	813	Shared Neighborhood Hits	51
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

FUT8_MOUSE
NC score	0.057426 (rank : 600)	θ value	1.38821 (rank : 250)
Query Neighborhood Hits	446	Target Neighborhood Hits	115	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WTS2, Q921U1	Gene names	Fut8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

AATK_HUMAN
NC score	0.057391 (rank : 601)	θ value	5.27518 (rank : 357)
Query Neighborhood Hits	446	Target Neighborhood Hits	1243	Shared Neighborhood Hits	101
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

CIC_HUMAN
NC score	0.057270 (rank : 602)	θ value	6.88961 (rank : 388)
Query Neighborhood Hits	446	Target Neighborhood Hits	992	Shared Neighborhood Hits	107
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

FAK2_HUMAN
NC score	0.057246 (rank : 603)	θ value	θ > 10 (rank : 562)
Query Neighborhood Hits	446	Target Neighborhood Hits	847	Shared Neighborhood Hits	51
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

HAPIP_HUMAN
NC score	0.057239 (rank : 604)	θ value	θ > 10 (rank : 590)
Query Neighborhood Hits	446	Target Neighborhood Hits	350	Shared Neighborhood Hits	32
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ERBB4_HUMAN
NC score	0.057166 (rank : 605)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	446	Target Neighborhood Hits	910	Shared Neighborhood Hits	54
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

FAK2_MOUSE
NC score	0.057164 (rank : 606)	θ value	θ > 10 (rank : 563)
Query Neighborhood Hits	446	Target Neighborhood Hits	851	Shared Neighborhood Hits	52
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

RUSC2_MOUSE
NC score	0.057022 (rank : 607)	θ value	θ > 10 (rank : 765)
Query Neighborhood Hits	446	Target Neighborhood Hits	305	Shared Neighborhood Hits	81
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

ALK_HUMAN
NC score	0.056938 (rank : 608)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	446	Target Neighborhood Hits	795	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

MLKL_MOUSE
NC score	0.056863 (rank : 609)	θ value	θ > 10 (rank : 655)
Query Neighborhood Hits	446	Target Neighborhood Hits	707	Shared Neighborhood Hits	50
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLL2_HUMAN
NC score	0.056786 (rank : 610)	θ value	θ > 10 (rank : 656)
Query Neighborhood Hits	446	Target Neighborhood Hits	1788	Shared Neighborhood Hits	131
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

LIMK2_HUMAN
NC score	0.056728 (rank : 611)	θ value	θ > 10 (rank : 630)
Query Neighborhood Hits	446	Target Neighborhood Hits	986	Shared Neighborhood Hits	97
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

SHD_HUMAN
NC score	0.056717 (rank : 612)	θ value	θ > 10 (rank : 779)
Query Neighborhood Hits	446	Target Neighborhood Hits	204	Shared Neighborhood Hits	41
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

FGD6_MOUSE
NC score	0.056610 (rank : 613)	θ value	θ > 10 (rank : 577)
Query Neighborhood Hits	446	Target Neighborhood Hits	282	Shared Neighborhood Hits	52
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

MINT_MOUSE
NC score	0.056486 (rank : 614)	θ value	5.27518 (rank : 367)
Query Neighborhood Hits	446	Target Neighborhood Hits	1514	Shared Neighborhood Hits	120
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

PKHG4_HUMAN
NC score	0.056469 (rank : 615)	θ value	θ > 10 (rank : 727)
Query Neighborhood Hits	446	Target Neighborhood Hits	200	Shared Neighborhood Hits	28
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

SHC2_HUMAN
NC score	0.056459 (rank : 616)	θ value	θ > 10 (rank : 775)
Query Neighborhood Hits	446	Target Neighborhood Hits	170	Shared Neighborhood Hits	47
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

ROS_HUMAN
NC score	0.056454 (rank : 617)	θ value	θ > 10 (rank : 762)
Query Neighborhood Hits	446	Target Neighborhood Hits	907	Shared Neighborhood Hits	58
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

CDN1C_HUMAN
NC score	0.056382 (rank : 618)	θ value	4.03905 (rank : 336)
Query Neighborhood Hits	446	Target Neighborhood Hits	168	Shared Neighborhood Hits	41
SwissProt Accessions	P49918	Gene names	CDKN1C, KIP2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57KIP2).

MERTK_MOUSE
NC score	0.056371 (rank : 619)	θ value	θ > 10 (rank : 651)
Query Neighborhood Hits	446	Target Neighborhood Hits	974	Shared Neighborhood Hits	55
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

ERBB3_MOUSE
NC score	0.056358 (rank : 620)	θ value	4.03905 (rank : 340)
Query Neighborhood Hits	446	Target Neighborhood Hits	898	Shared Neighborhood Hits	52
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

CEND3_HUMAN
NC score	0.056202 (rank : 621)	θ value	0.62314 (rank : 210)
Query Neighborhood Hits	446	Target Neighborhood Hits	275	Shared Neighborhood Hits	58
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

K1802_MOUSE
NC score	0.056138 (rank : 622)	θ value	0.62314 (rank : 212)
Query Neighborhood Hits	446	Target Neighborhood Hits	1596	Shared Neighborhood Hits	112
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MAGE1_HUMAN
NC score	0.056068 (rank : 623)	θ value	4.03905 (rank : 342)
Query Neighborhood Hits	446	Target Neighborhood Hits	1389	Shared Neighborhood Hits	124
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

NTRK1_HUMAN
NC score	0.055953 (rank : 624)	θ value	θ > 10 (rank : 683)
Query Neighborhood Hits	446	Target Neighborhood Hits	1023	Shared Neighborhood Hits	53
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

INSRR_HUMAN
NC score	0.055784 (rank : 625)	θ value	θ > 10 (rank : 602)
Query Neighborhood Hits	446	Target Neighborhood Hits	950	Shared Neighborhood Hits	53
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

ERBB3_HUMAN
NC score	0.055746 (rank : 626)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	446	Target Neighborhood Hits	918	Shared Neighborhood Hits	50
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ROR2_MOUSE
NC score	0.055596 (rank : 627)	θ value	θ > 10 (rank : 761)
Query Neighborhood Hits	446	Target Neighborhood Hits	1000	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

SH21B_MOUSE
NC score	0.055572 (rank : 628)	θ value	θ > 10 (rank : 770)
Query Neighborhood Hits	446	Target Neighborhood Hits	101	Shared Neighborhood Hits	27
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

ROR1_HUMAN
NC score	0.055553 (rank : 629)	θ value	θ > 10 (rank : 758)
Query Neighborhood Hits	446	Target Neighborhood Hits	1018	Shared Neighborhood Hits	51
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

ROR2_HUMAN
NC score	0.055513 (rank : 630)	θ value	θ > 10 (rank : 760)
Query Neighborhood Hits	446	Target Neighborhood Hits	1014	Shared Neighborhood Hits	52
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

AATK_MOUSE
NC score	0.055436 (rank : 631)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	446	Target Neighborhood Hits	942	Shared Neighborhood Hits	83
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ENAH_MOUSE
NC score	0.055357 (rank : 632)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	446	Target Neighborhood Hits	919	Shared Neighborhood Hits	100
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

MERTK_HUMAN
NC score	0.055315 (rank : 633)	θ value	θ > 10 (rank : 650)
Query Neighborhood Hits	446	Target Neighborhood Hits	988	Shared Neighborhood Hits	58
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

FAK1_MOUSE
NC score	0.055296 (rank : 634)	θ value	θ > 10 (rank : 561)
Query Neighborhood Hits	446	Target Neighborhood Hits	850	Shared Neighborhood Hits	52
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK1_HUMAN
NC score	0.055260 (rank : 635)	θ value	θ > 10 (rank : 560)
Query Neighborhood Hits	446	Target Neighborhood Hits	850	Shared Neighborhood Hits	52
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

STYK1_MOUSE
NC score	0.055222 (rank : 636)	θ value	θ > 10 (rank : 822)
Query Neighborhood Hits	446	Target Neighborhood Hits	779	Shared Neighborhood Hits	51
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

ROR1_MOUSE
NC score	0.055181 (rank : 637)	θ value	θ > 10 (rank : 759)
Query Neighborhood Hits	446	Target Neighborhood Hits	1025	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

K1802_HUMAN
NC score	0.055177 (rank : 638)	θ value	0.47712 (rank : 199)
Query Neighborhood Hits	446	Target Neighborhood Hits	1378	Shared Neighborhood Hits	108
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

INSR_MOUSE
NC score	0.055169 (rank : 639)	θ value	θ > 10 (rank : 605)
Query Neighborhood Hits	446	Target Neighborhood Hits	968	Shared Neighborhood Hits	55
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

FARP2_MOUSE
NC score	0.055051 (rank : 640)	θ value	θ > 10 (rank : 565)
Query Neighborhood Hits	446	Target Neighborhood Hits	209	Shared Neighborhood Hits	39
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

CK024_HUMAN
NC score	0.055018 (rank : 641)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	446	Target Neighborhood Hits	408	Shared Neighborhood Hits	63
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

INSRR_MOUSE
NC score	0.054906 (rank : 642)	θ value	θ > 10 (rank : 603)
Query Neighborhood Hits	446	Target Neighborhood Hits	961	Shared Neighborhood Hits	56
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSR_HUMAN
NC score	0.054902 (rank : 643)	θ value	θ > 10 (rank : 604)
Query Neighborhood Hits	446	Target Neighborhood Hits	963	Shared Neighborhood Hits	52
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

GRIN1_HUMAN
NC score	0.054829 (rank : 644)	θ value	6.88961 (rank : 398)
Query Neighborhood Hits	446	Target Neighborhood Hits	681	Shared Neighborhood Hits	72
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

SHB_MOUSE
NC score	0.054827 (rank : 645)	θ value	θ > 10 (rank : 772)
Query Neighborhood Hits	446	Target Neighborhood Hits	137	Shared Neighborhood Hits	34
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

BCAS1_MOUSE
NC score	0.054808 (rank : 646)	θ value	0.21417 (rank : 169)
Query Neighborhood Hits	446	Target Neighborhood Hits	215	Shared Neighborhood Hits	30
SwissProt Accessions	Q80YN3, Q9CVA1	Gene names	Bcas1, Nabc1
Domain Architecture	No domain graphic available
Description	Breast carcinoma amplified sequence 1 homolog (Novel amplified in breast cancer 1 homolog).

EPS8_MOUSE
NC score	0.054758 (rank : 647)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	446	Target Neighborhood Hits	157	Shared Neighborhood Hits	74
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

JIP1_MOUSE
NC score	0.054594 (rank : 648)	θ value	5.27518 (rank : 362)
Query Neighborhood Hits	446	Target Neighborhood Hits	259	Shared Neighborhood Hits	72
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

MET_HUMAN
NC score	0.054583 (rank : 649)	θ value	θ > 10 (rank : 652)
Query Neighborhood Hits	446	Target Neighborhood Hits	831	Shared Neighborhood Hits	51
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MET_MOUSE
NC score	0.054490 (rank : 650)	θ value	θ > 10 (rank : 653)
Query Neighborhood Hits	446	Target Neighborhood Hits	844	Shared Neighborhood Hits	52
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

RON_MOUSE
NC score	0.054217 (rank : 651)	θ value	θ > 10 (rank : 757)
Query Neighborhood Hits	446	Target Neighborhood Hits	836	Shared Neighborhood Hits	52
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

WNK2_HUMAN
NC score	0.054187 (rank : 652)	θ value	θ > 10 (rank : 847)
Query Neighborhood Hits	446	Target Neighborhood Hits	1407	Shared Neighborhood Hits	138
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

TYRO3_MOUSE
NC score	0.054165 (rank : 653)	θ value	θ > 10 (rank : 841)
Query Neighborhood Hits	446	Target Neighborhood Hits	1007	Shared Neighborhood Hits	55
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

ARAF_HUMAN
NC score	0.053999 (rank : 654)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	446	Target Neighborhood Hits	924	Shared Neighborhood Hits	64
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

RHPN2_MOUSE
NC score	0.053971 (rank : 655)	θ value	θ > 10 (rank : 749)
Query Neighborhood Hits	446	Target Neighborhood Hits	60	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BWR8, Q9DBN2	Gene names	Rhpn2
Domain Architecture	No domain graphic available
Description	Rhophilin-2 (GTP-Rho-binding protein 2).

UFO_HUMAN
NC score	0.053891 (rank : 656)	θ value	θ > 10 (rank : 842)
Query Neighborhood Hits	446	Target Neighborhood Hits	981	Shared Neighborhood Hits	56
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

PRG4_MOUSE
NC score	0.053882 (rank : 657)	θ value	θ > 10 (rank : 733)
Query Neighborhood Hits	446	Target Neighborhood Hits	624	Shared Neighborhood Hits	77
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

RGP2_HUMAN
NC score	0.053860 (rank : 658)	θ value	θ > 10 (rank : 746)
Query Neighborhood Hits	446	Target Neighborhood Hits	60	Shared Neighborhood Hits	11
SwissProt Accessions	P47736	Gene names	RAP1GAP, RAP1GA1
Domain Architecture
Description	Rap1 GTPase-activating protein 1 (Rap1GAP).

ARAF_MOUSE
NC score	0.053824 (rank : 659)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	446	Target Neighborhood Hits	874	Shared Neighborhood Hits	59
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

GIPC2_HUMAN
NC score	0.053790 (rank : 660)	θ value	θ > 10 (rank : 585)
Query Neighborhood Hits	446	Target Neighborhood Hits	93	Shared Neighborhood Hits	58
SwissProt Accessions	Q8TF65, Q8IYD3, Q9NXS7	Gene names	GIPC2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2.

TNKS1_HUMAN
NC score	0.053768 (rank : 661)	θ value	1.06291 (rank : 245)
Query Neighborhood Hits	446	Target Neighborhood Hits	477	Shared Neighborhood Hits	54
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

NTRK3_HUMAN
NC score	0.053604 (rank : 662)	θ value	θ > 10 (rank : 686)
Query Neighborhood Hits	446	Target Neighborhood Hits	1115	Shared Neighborhood Hits	52
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

MUC1_MOUSE
NC score	0.053590 (rank : 663)	θ value	θ > 10 (rank : 666)
Query Neighborhood Hits	446	Target Neighborhood Hits	388	Shared Neighborhood Hits	48
SwissProt Accessions	Q02496	Gene names	Muc1, Muc-1
Domain Architecture
Description	Mucin-1 precursor (Polymorphic epithelial mucin) (PEMT) (Episialin).

BASP_MOUSE
NC score	0.053565 (rank : 664)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	446	Target Neighborhood Hits	260	Shared Neighborhood Hits	42
SwissProt Accessions	Q91XV3	Gene names	Basp1, Nap22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

DOT1L_HUMAN
NC score	0.053350 (rank : 665)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	446	Target Neighborhood Hits	660	Shared Neighborhood Hits	76
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

RON_HUMAN
NC score	0.053338 (rank : 666)	θ value	θ > 10 (rank : 756)
Query Neighborhood Hits	446	Target Neighborhood Hits	842	Shared Neighborhood Hits	52
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

SHE_HUMAN
NC score	0.053326 (rank : 667)	θ value	θ > 10 (rank : 781)
Query Neighborhood Hits	446	Target Neighborhood Hits	164	Shared Neighborhood Hits	37
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHC2_MOUSE
NC score	0.053295 (rank : 668)	θ value	θ > 10 (rank : 776)
Query Neighborhood Hits	446	Target Neighborhood Hits	144	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

BRAF1_HUMAN
NC score	0.053289 (rank : 669)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	446	Target Neighborhood Hits	883	Shared Neighborhood Hits	63
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

RIPK2_HUMAN
NC score	0.053252 (rank : 670)	θ value	θ > 10 (rank : 752)
Query Neighborhood Hits	446	Target Neighborhood Hits	774	Shared Neighborhood Hits	50
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

IGF1R_MOUSE
NC score	0.053247 (rank : 671)	θ value	θ > 10 (rank : 596)
Query Neighborhood Hits	446	Target Neighborhood Hits	973	Shared Neighborhood Hits	52
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

RAF1_HUMAN
NC score	0.053224 (rank : 672)	θ value	θ > 10 (rank : 739)
Query Neighborhood Hits	446	Target Neighborhood Hits	886	Shared Neighborhood Hits	61
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

ATN1_HUMAN
NC score	0.053146 (rank : 673)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	446	Target Neighborhood Hits	676	Shared Neighborhood Hits	72
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

RAF1_MOUSE
NC score	0.053068 (rank : 674)	θ value	θ > 10 (rank : 740)
Query Neighborhood Hits	446	Target Neighborhood Hits	886	Shared Neighborhood Hits	61
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

FUT8_HUMAN
NC score	0.052972 (rank : 675)	θ value	8.99809 (rank : 426)
Query Neighborhood Hits	446	Target Neighborhood Hits	67	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

TYRO3_HUMAN
NC score	0.052948 (rank : 676)	θ value	θ > 10 (rank : 840)
Query Neighborhood Hits	446	Target Neighborhood Hits	995	Shared Neighborhood Hits	53
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

KIT_MOUSE
NC score	0.052871 (rank : 677)	θ value	θ > 10 (rank : 615)
Query Neighborhood Hits	446	Target Neighborhood Hits	949	Shared Neighborhood Hits	51
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

UFO_MOUSE
NC score	0.052840 (rank : 678)	θ value	θ > 10 (rank : 843)
Query Neighborhood Hits	446	Target Neighborhood Hits	988	Shared Neighborhood Hits	55
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

SHB_HUMAN
NC score	0.052838 (rank : 679)	θ value	θ > 10 (rank : 771)
Query Neighborhood Hits	446	Target Neighborhood Hits	141	Shared Neighborhood Hits	34
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHD_MOUSE
NC score	0.052815 (rank : 680)	θ value	θ > 10 (rank : 780)
Query Neighborhood Hits	446	Target Neighborhood Hits	137	Shared Neighborhood Hits	37
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

IGF1R_HUMAN
NC score	0.052785 (rank : 681)	θ value	θ > 10 (rank : 595)
Query Neighborhood Hits	446	Target Neighborhood Hits	977	Shared Neighborhood Hits	53
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

MUSK_MOUSE
NC score	0.052652 (rank : 682)	θ value	θ > 10 (rank : 669)
Query Neighborhood Hits	446	Target Neighborhood Hits	1057	Shared Neighborhood Hits	51
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

K1543_HUMAN
NC score	0.052651 (rank : 683)	θ value	1.06291 (rank : 239)
Query Neighborhood Hits	446	Target Neighborhood Hits	435	Shared Neighborhood Hits	56
SwissProt Accessions	Q9P1Y5, Q8NDF1	Gene names	KIAA1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

RIPK2_MOUSE
NC score	0.052562 (rank : 684)	θ value	θ > 10 (rank : 753)
Query Neighborhood Hits	446	Target Neighborhood Hits	776	Shared Neighborhood Hits	50
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

KIT_HUMAN
NC score	0.052412 (rank : 685)	θ value	θ > 10 (rank : 614)
Query Neighborhood Hits	446	Target Neighborhood Hits	953	Shared Neighborhood Hits	51
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

BAG3_MOUSE
NC score	0.052396 (rank : 686)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	446	Target Neighborhood Hits	513	Shared Neighborhood Hits	75
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

MUSK_HUMAN
NC score	0.052362 (rank : 687)	θ value	θ > 10 (rank : 668)
Query Neighborhood Hits	446	Target Neighborhood Hits	1074	Shared Neighborhood Hits	53
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

KSR1_MOUSE
NC score	0.052340 (rank : 688)	θ value	θ > 10 (rank : 617)
Query Neighborhood Hits	446	Target Neighborhood Hits	870	Shared Neighborhood Hits	62
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

PGFRB_MOUSE
NC score	0.052335 (rank : 689)	θ value	θ > 10 (rank : 723)
Query Neighborhood Hits	446	Target Neighborhood Hits	960	Shared Neighborhood Hits	50
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PGFRB_HUMAN
NC score	0.052314 (rank : 690)	θ value	θ > 10 (rank : 722)
Query Neighborhood Hits	446	Target Neighborhood Hits	962	Shared Neighborhood Hits	52
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

KGUA_HUMAN
NC score	0.052248 (rank : 691)	θ value	θ > 10 (rank : 612)
Query Neighborhood Hits	446	Target Neighborhood Hits	41	Shared Neighborhood Hits	14
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KGUA_MOUSE
NC score	0.052228 (rank : 692)	θ value	θ > 10 (rank : 613)
Query Neighborhood Hits	446	Target Neighborhood Hits	45	Shared Neighborhood Hits	14
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

RPB1_MOUSE
NC score	0.052142 (rank : 693)	θ value	1.81305 (rank : 286)
Query Neighborhood Hits	446	Target Neighborhood Hits	363	Shared Neighborhood Hits	52
SwissProt Accessions	P08775	Gene names	Polr2a, Rpii215, Rpo2-1
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

KSR1_HUMAN
NC score	0.052141 (rank : 694)	θ value	θ > 10 (rank : 616)
Query Neighborhood Hits	446	Target Neighborhood Hits	867	Shared Neighborhood Hits	62
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

CS016_HUMAN
NC score	0.052120 (rank : 695)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	446	Target Neighborhood Hits	310	Shared Neighborhood Hits	56
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

SPN90_MOUSE
NC score	0.052099 (rank : 696)	θ value	θ > 10 (rank : 802)
Query Neighborhood Hits	446	Target Neighborhood Hits	157	Shared Neighborhood Hits	54
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

RET_MOUSE
NC score	0.052095 (rank : 697)	θ value	θ > 10 (rank : 744)
Query Neighborhood Hits	446	Target Neighborhood Hits	884	Shared Neighborhood Hits	52
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

STYK1_HUMAN
NC score	0.052059 (rank : 698)	θ value	θ > 10 (rank : 821)
Query Neighborhood Hits	446	Target Neighborhood Hits	786	Shared Neighborhood Hits	49
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

FLT3_MOUSE
NC score	0.051970 (rank : 699)	θ value	θ > 10 (rank : 579)
Query Neighborhood Hits	446	Target Neighborhood Hits	847	Shared Neighborhood Hits	50
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

NTRK2_HUMAN
NC score	0.051885 (rank : 700)	θ value	θ > 10 (rank : 684)
Query Neighborhood Hits	446	Target Neighborhood Hits	1081	Shared Neighborhood Hits	52
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

FLT3_HUMAN
NC score	0.051814 (rank : 701)	θ value	θ > 10 (rank : 578)
Query Neighborhood Hits	446	Target Neighborhood Hits	843	Shared Neighborhood Hits	49
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

P55G_HUMAN
NC score	0.051800 (rank : 702)	θ value	θ > 10 (rank : 688)
Query Neighborhood Hits	446	Target Neighborhood Hits	451	Shared Neighborhood Hits	45
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

NTRK2_MOUSE
NC score	0.051746 (rank : 703)	θ value	θ > 10 (rank : 685)
Query Neighborhood Hits	446	Target Neighborhood Hits	1088	Shared Neighborhood Hits	52
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

M3K12_HUMAN
NC score	0.051651 (rank : 704)	θ value	θ > 10 (rank : 641)
Query Neighborhood Hits	446	Target Neighborhood Hits	940	Shared Neighborhood Hits	62
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

CJ078_MOUSE
NC score	0.051587 (rank : 705)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	446	Target Neighborhood Hits	559	Shared Neighborhood Hits	67
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

DOCK1_HUMAN
NC score	0.051555 (rank : 706)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	446	Target Neighborhood Hits	191	Shared Neighborhood Hits	78
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

RET_HUMAN
NC score	0.051508 (rank : 707)	θ value	θ > 10 (rank : 743)
Query Neighborhood Hits	446	Target Neighborhood Hits	873	Shared Neighborhood Hits	50
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

M3K12_MOUSE
NC score	0.051462 (rank : 708)	θ value	θ > 10 (rank : 642)
Query Neighborhood Hits	446	Target Neighborhood Hits	957	Shared Neighborhood Hits	61
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

CSF1R_HUMAN
NC score	0.051193 (rank : 709)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	446	Target Neighborhood Hits	943	Shared Neighborhood Hits	51
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

LPP_HUMAN
NC score	0.051116 (rank : 710)	θ value	0.163984 (rank : 163)
Query Neighborhood Hits	446	Target Neighborhood Hits	775	Shared Neighborhood Hits	73
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

M3K13_HUMAN
NC score	0.051015 (rank : 711)	θ value	θ > 10 (rank : 643)
Query Neighborhood Hits	446	Target Neighborhood Hits	911	Shared Neighborhood Hits	52
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

ES8L1_HUMAN
NC score	0.051008 (rank : 712)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	446	Target Neighborhood Hits	162	Shared Neighborhood Hits	65
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

STS1_MOUSE
NC score	0.050963 (rank : 713)	θ value	θ > 10 (rank : 817)
Query Neighborhood Hits	446	Target Neighborhood Hits	104	Shared Neighborhood Hits	54
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

PGFRA_MOUSE
NC score	0.050959 (rank : 714)	θ value	θ > 10 (rank : 721)
Query Neighborhood Hits	446	Target Neighborhood Hits	975	Shared Neighborhood Hits	51
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

CSF1_HUMAN
NC score	0.050929 (rank : 715)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	446	Target Neighborhood Hits	258	Shared Neighborhood Hits	45
SwissProt Accessions	P09603, Q13130, Q14086, Q14806, Q9UQR8	Gene names	CSF1
Domain Architecture
Description	Macrophage colony-stimulating factor 1 precursor (CSF-1) (MCSF) (M- CSF) (Lanimostim).

GGN_MOUSE
NC score	0.050904 (rank : 716)	θ value	θ > 10 (rank : 582)
Query Neighborhood Hits	446	Target Neighborhood Hits	311	Shared Neighborhood Hits	60
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

TIE2_HUMAN
NC score	0.050746 (rank : 717)	θ value	θ > 10 (rank : 831)
Query Neighborhood Hits	446	Target Neighborhood Hits	1192	Shared Neighborhood Hits	59
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

LRRK1_MOUSE
NC score	0.050683 (rank : 718)	θ value	θ > 10 (rank : 636)
Query Neighborhood Hits	446	Target Neighborhood Hits	1267	Shared Neighborhood Hits	66
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

GGN_HUMAN
NC score	0.050633 (rank : 719)	θ value	θ > 10 (rank : 581)
Query Neighborhood Hits	446	Target Neighborhood Hits	269	Shared Neighborhood Hits	58
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

CEND3_MOUSE
NC score	0.050588 (rank : 720)	θ value	0.813845 (rank : 222)
Query Neighborhood Hits	446	Target Neighborhood Hits	228	Shared Neighborhood Hits	49
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

PGFRA_HUMAN
NC score	0.050586 (rank : 721)	θ value	θ > 10 (rank : 720)
Query Neighborhood Hits	446	Target Neighborhood Hits	980	Shared Neighborhood Hits	51
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

IRAK1_HUMAN
NC score	0.050563 (rank : 722)	θ value	θ > 10 (rank : 606)
Query Neighborhood Hits	446	Target Neighborhood Hits	820	Shared Neighborhood Hits	64
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

TIE2_MOUSE
NC score	0.050551 (rank : 723)	θ value	θ > 10 (rank : 832)
Query Neighborhood Hits	446	Target Neighborhood Hits	1204	Shared Neighborhood Hits	56
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

LIPA2_HUMAN
NC score	0.050509 (rank : 724)	θ value	3.0926 (rank : 318)
Query Neighborhood Hits	446	Target Neighborhood Hits	1044	Shared Neighborhood Hits	48
SwissProt Accessions	O75334	Gene names	PPFIA2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

LRRK1_HUMAN
NC score	0.050461 (rank : 725)	θ value	θ > 10 (rank : 635)
Query Neighborhood Hits	446	Target Neighborhood Hits	1237	Shared Neighborhood Hits	67
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

RIPK3_HUMAN
NC score	0.050434 (rank : 726)	θ value	θ > 10 (rank : 754)
Query Neighborhood Hits	446	Target Neighborhood Hits	828	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

P55G_MOUSE
NC score	0.050367 (rank : 727)	θ value	θ > 10 (rank : 689)
Query Neighborhood Hits	446	Target Neighborhood Hits	401	Shared Neighborhood Hits	43
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

PELP1_MOUSE
NC score	0.050341 (rank : 728)	θ value	θ > 10 (rank : 717)
Query Neighborhood Hits	446	Target Neighborhood Hits	709	Shared Neighborhood Hits	77
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

ANPRA_MOUSE
NC score	0.050270 (rank : 729)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	446	Target Neighborhood Hits	600	Shared Neighborhood Hits	49
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

M3K7_MOUSE
NC score	0.050242 (rank : 730)	θ value	θ > 10 (rank : 645)
Query Neighborhood Hits	446	Target Neighborhood Hits	892	Shared Neighborhood Hits	53
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

SH21B_HUMAN
NC score	0.050236 (rank : 731)	θ value	θ > 10 (rank : 769)
Query Neighborhood Hits	446	Target Neighborhood Hits	101	Shared Neighborhood Hits	25
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

CSF1R_MOUSE
NC score	0.050214 (rank : 732)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	446	Target Neighborhood Hits	983	Shared Neighborhood Hits	50
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

BAG3_HUMAN
NC score	0.050209 (rank : 733)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	446	Target Neighborhood Hits	314	Shared Neighborhood Hits	62
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

MLL3_MOUSE
NC score	0.050203 (rank : 734)	θ value	θ > 10 (rank : 657)
Query Neighborhood Hits	446	Target Neighborhood Hits	1399	Shared Neighborhood Hits	93
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

M3K7_HUMAN
NC score	0.050171 (rank : 735)	θ value	θ > 10 (rank : 644)
Query Neighborhood Hits	446	Target Neighborhood Hits	892	Shared Neighborhood Hits	52
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

STS1_HUMAN
NC score	0.050145 (rank : 736)	θ value	θ > 10 (rank : 816)
Query Neighborhood Hits	446	Target Neighborhood Hits	106	Shared Neighborhood Hits	54
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

JAK1_HUMAN
NC score	0.050050 (rank : 737)	θ value	θ > 10 (rank : 611)
Query Neighborhood Hits	446	Target Neighborhood Hits	858	Shared Neighborhood Hits	50
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

RPB1_HUMAN
NC score	0.050020 (rank : 738)	θ value	3.0926 (rank : 329)
Query Neighborhood Hits	446	Target Neighborhood Hits	362	Shared Neighborhood Hits	52
SwissProt Accessions	P24928	Gene names	POLR2A
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

FARP1_HUMAN
NC score	0.050012 (rank : 739)	θ value	θ > 10 (rank : 564)
Query Neighborhood Hits	446	Target Neighborhood Hits	241	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

ANKS6_MOUSE
NC score	0.047811 (rank : 740)	θ value	8.99809 (rank : 419)
Query Neighborhood Hits	446	Target Neighborhood Hits	435	Shared Neighborhood Hits	48
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

LIPA2_MOUSE
NC score	0.047032 (rank : 741)	θ value	3.0926 (rank : 319)
Query Neighborhood Hits	446	Target Neighborhood Hits	1282	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BSS9, Q8BN73	Gene names	Ppfia2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

LMBL3_MOUSE
NC score	0.046651 (rank : 742)	θ value	2.36792 (rank : 298)
Query Neighborhood Hits	446	Target Neighborhood Hits	212	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BLB7, Q641L7, Q6ZPI2, Q8C0G4	Gene names	L3mbtl3
Domain Architecture	No domain graphic available
Description	Lethal(3)malignant brain tumor-like 3 protein (L(3)mbt-like 3 protein).

ANKS6_HUMAN
NC score	0.045221 (rank : 743)	θ value	8.99809 (rank : 418)
Query Neighborhood Hits	446	Target Neighborhood Hits	411	Shared Neighborhood Hits	40
SwissProt Accessions	Q68DC2, Q5VSL0, Q5VSL2, Q5VSL3, Q5VSL4, Q68DB8, Q6P2R2, Q8N9L6, Q96D62	Gene names	ANKS6, ANKRD14, SAMD6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6) (Ankyrin repeat domain-containing protein 14).

MILK1_MOUSE
NC score	0.044853 (rank : 744)	θ value	4.03905 (rank : 343)
Query Neighborhood Hits	446	Target Neighborhood Hits	788	Shared Neighborhood Hits	91
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

NOL1_HUMAN
NC score	0.044652 (rank : 745)	θ value	0.62314 (rank : 215)
Query Neighborhood Hits	446	Target Neighborhood Hits	74	Shared Neighborhood Hits	10
SwissProt Accessions	P46087	Gene names	NOL1
Domain Architecture
Description	Proliferating-cell nucleolar antigen p120 (Proliferation-associated nucleolar protein p120).

ACINU_MOUSE
NC score	0.044379 (rank : 746)	θ value	3.0926 (rank : 309)
Query Neighborhood Hits	446	Target Neighborhood Hits	712	Shared Neighborhood Hits	64
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

PF21A_HUMAN
NC score	0.043407 (rank : 747)	θ value	0.47712 (rank : 201)
Query Neighborhood Hits	446	Target Neighborhood Hits	303	Shared Neighborhood Hits	20
SwissProt Accessions	Q96BD5, Q6AWA2, Q9C0G7, Q9H8V9, Q9HAK6, Q9NZE9	Gene names	PHF21A, BHC80, KIAA1696
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (BHC80a).

AMBN_HUMAN
NC score	0.043254 (rank : 748)	θ value	0.279714 (rank : 182)
Query Neighborhood Hits	446	Target Neighborhood Hits	107	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NP70, Q9H2X1, Q9H4L1	Gene names	AMBN
Domain Architecture
Description	Ameloblastin precursor.

MAML2_HUMAN
NC score	0.042931 (rank : 749)	θ value	0.62314 (rank : 213)
Query Neighborhood Hits	446	Target Neighborhood Hits	360	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IZL2, Q6AI23, Q6Y3A3, Q8IUL3, Q96JK6	Gene names	MAML2, KIAA1819
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 2 (Mam-2).

LIPA1_HUMAN
NC score	0.042818 (rank : 750)	θ value	6.88961 (rank : 401)
Query Neighborhood Hits	446	Target Neighborhood Hits	1294	Shared Neighborhood Hits	57
SwissProt Accessions	Q13136, Q13135, Q14567, Q8N4I2	Gene names	PPFIA1, LIP1
Domain Architecture
Description	Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) (LAR-interacting protein 1) (LIP.1).

CS007_MOUSE
NC score	0.042268 (rank : 751)	θ value	6.88961 (rank : 390)
Query Neighborhood Hits	446	Target Neighborhood Hits	464	Shared Neighborhood Hits	55
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

IWS1_HUMAN
NC score	0.040311 (rank : 752)	θ value	1.81305 (rank : 276)
Query Neighborhood Hits	446	Target Neighborhood Hits	1241	Shared Neighborhood Hits	80
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

LAD1_MOUSE
NC score	0.040223 (rank : 753)	θ value	8.99809 (rank : 432)
Query Neighborhood Hits	446	Target Neighborhood Hits	391	Shared Neighborhood Hits	47
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

LMBL3_HUMAN
NC score	0.040201 (rank : 754)	θ value	2.36792 (rank : 297)
Query Neighborhood Hits	446	Target Neighborhood Hits	88	Shared Neighborhood Hits	16
SwissProt Accessions	Q96JM7, Q5VUM9, Q6P9B5	Gene names	L3MBTL3, KIAA1798
Domain Architecture	No domain graphic available
Description	Lethal(3)malignant brain tumor-like 3 protein (L(3)mbt-like 3 protein) (H-l(3)mbt-like protein).

WNK4_MOUSE
NC score	0.040155 (rank : 755)	θ value	6.88961 (rank : 415)
Query Neighborhood Hits	446	Target Neighborhood Hits	961	Shared Neighborhood Hits	83
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

PRGR_MOUSE
NC score	0.039664 (rank : 756)	θ value	0.00175202 (rank : 57)
Query Neighborhood Hits	446	Target Neighborhood Hits	286	Shared Neighborhood Hits	27
SwissProt Accessions	Q00175	Gene names	Pgr, Nr3c3, Pr
Domain Architecture
Description	Progesterone receptor (PR).

MYLK_MOUSE
NC score	0.039499 (rank : 757)	θ value	8.99809 (rank : 435)
Query Neighborhood Hits	446	Target Neighborhood Hits	1489	Shared Neighborhood Hits	106
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

GAB1_HUMAN
NC score	0.038913 (rank : 758)	θ value	1.81305 (rank : 274)
Query Neighborhood Hits	446	Target Neighborhood Hits	279	Shared Neighborhood Hits	35
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GPTC8_HUMAN
NC score	0.038546 (rank : 759)	θ value	1.38821 (rank : 252)
Query Neighborhood Hits	446	Target Neighborhood Hits	366	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UKJ3, O60300	Gene names	GPATC8, KIAA0553
Domain Architecture	No domain graphic available
Description	G patch domain-containing protein 8.

RTN4_HUMAN
NC score	0.038243 (rank : 760)	θ value	4.03905 (rank : 351)
Query Neighborhood Hits	446	Target Neighborhood Hits	357	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NQC3, O94962, Q9BXG5, Q9H212, Q9H3I3, Q9UQ42, Q9Y293, Q9Y2Y7, Q9Y5U6	Gene names	RTN4, KIAA0886, NOGO
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) (Foocen) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5).

TERF2_HUMAN
NC score	0.037900 (rank : 761)	θ value	3.0926 (rank : 333)
Query Neighborhood Hits	446	Target Neighborhood Hits	102	Shared Neighborhood Hits	10
SwissProt Accessions	Q15554	Gene names	TERF2, TRF2
Domain Architecture
Description	Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein).

K0319_HUMAN
NC score	0.037564 (rank : 762)	θ value	1.38821 (rank : 254)
Query Neighborhood Hits	446	Target Neighborhood Hits	154	Shared Neighborhood Hits	21
SwissProt Accessions	Q5VV43, Q9UJC8, Q9Y4G7	Gene names	KIAA0319
Domain Architecture	No domain graphic available
Description	Protein KIAA0319 precursor.

NUAK1_HUMAN
NC score	0.037355 (rank : 763)	θ value	1.06291 (rank : 240)
Query Neighborhood Hits	446	Target Neighborhood Hits	874	Shared Neighborhood Hits	54
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

SEPT9_HUMAN
NC score	0.037037 (rank : 764)	θ value	0.0736092 (rank : 137)
Query Neighborhood Hits	446	Target Neighborhood Hits	706	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

NFIP2_HUMAN
NC score	0.035603 (rank : 765)	θ value	2.36792 (rank : 302)
Query Neighborhood Hits	446	Target Neighborhood Hits	72	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NV92, Q7Z2H3, Q7Z428, Q8TAR3, Q9ULQ5	Gene names	NDFIP2, KIAA1165, N4WBP5A
Domain Architecture	No domain graphic available
Description	NEDD4 family-interacting protein 2 (NEDD4 WW domain-binding protein 5A) (Putative MAPK-activating protein PM04/PM05/PM06/PM07) (Putative NF-kappa-B-activating protein 413).

AIM1_HUMAN
NC score	0.034667 (rank : 766)	θ value	1.06291 (rank : 236)
Query Neighborhood Hits	446	Target Neighborhood Hits	247	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y4K1, O00296, Q5VWJ2	Gene names	AIM1
Domain Architecture
Description	Absent in melanoma 1 protein.

PAK3_MOUSE
NC score	0.034264 (rank : 767)	θ value	1.38821 (rank : 257)
Query Neighborhood Hits	446	Target Neighborhood Hits	874	Shared Neighborhood Hits	53
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

CCDC9_MOUSE
NC score	0.034092 (rank : 768)	θ value	2.36792 (rank : 293)
Query Neighborhood Hits	446	Target Neighborhood Hits	196	Shared Neighborhood Hits	24
SwissProt Accessions	Q8VC31	Gene names	Ccdc9
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 9.

PAK1_HUMAN
NC score	0.033841 (rank : 769)	θ value	4.03905 (rank : 346)
Query Neighborhood Hits	446	Target Neighborhood Hits	873	Shared Neighborhood Hits	52
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

PAK1_MOUSE
NC score	0.033718 (rank : 770)	θ value	5.27518 (rank : 368)
Query Neighborhood Hits	446	Target Neighborhood Hits	878	Shared Neighborhood Hits	54
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

PAK3_HUMAN
NC score	0.033586 (rank : 771)	θ value	4.03905 (rank : 347)
Query Neighborhood Hits	446	Target Neighborhood Hits	887	Shared Neighborhood Hits	53
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

SYNPO_HUMAN
NC score	0.033192 (rank : 772)	θ value	6.88961 (rank : 411)
Query Neighborhood Hits	446	Target Neighborhood Hits	281	Shared Neighborhood Hits	44
SwissProt Accessions	Q8N3V7, O15271, Q9UPX1	Gene names	SYNPO, KIAA1029
Domain Architecture	No domain graphic available
Description	Synaptopodin.

CAC1G_HUMAN
NC score	0.033074 (rank : 773)	θ value	0.365318 (rank : 191)
Query Neighborhood Hits	446	Target Neighborhood Hits	587	Shared Neighborhood Hits	61
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

MYCB2_HUMAN
NC score	0.032971 (rank : 774)	θ value	0.279714 (rank : 188)
Query Neighborhood Hits	446	Target Neighborhood Hits	390	Shared Neighborhood Hits	34
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

ECM1_MOUSE
NC score	0.032110 (rank : 775)	θ value	1.81305 (rank : 272)
Query Neighborhood Hits	446	Target Neighborhood Hits	105	Shared Neighborhood Hits	15
SwissProt Accessions	Q61508	Gene names	Ecm1
Domain Architecture
Description	Extracellular matrix protein 1 precursor (Secretory component p85).

K1688_HUMAN
NC score	0.031919 (rank : 776)	θ value	4.03905 (rank : 341)
Query Neighborhood Hits	446	Target Neighborhood Hits	217	Shared Neighborhood Hits	33
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

SEN34_MOUSE
NC score	0.030976 (rank : 777)	θ value	1.38821 (rank : 264)
Query Neighborhood Hits	446	Target Neighborhood Hits	158	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BMZ5, Q58EU2, Q99LV6, Q9CYW1	Gene names	Tsen34, Leng5, Sen34
Domain Architecture	No domain graphic available
Description	tRNA-splicing endonuclease subunit Sen34 (EC 3.1.27.9) (tRNA-intron endonuclease Sen34) (Leukocyte receptor cluster member 5 homolog).

JPH2_HUMAN
NC score	0.029401 (rank : 778)	θ value	1.81305 (rank : 277)
Query Neighborhood Hits	446	Target Neighborhood Hits	639	Shared Neighborhood Hits	55
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

NFH_HUMAN
NC score	0.028523 (rank : 779)	θ value	2.36792 (rank : 301)
Query Neighborhood Hits	446	Target Neighborhood Hits	1242	Shared Neighborhood Hits	89
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

CT055_HUMAN
NC score	0.028452 (rank : 780)	θ value	4.03905 (rank : 338)
Query Neighborhood Hits	446	Target Neighborhood Hits	42	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BQ89	Gene names	C20orf55
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf55.

TGON1_MOUSE
NC score	0.027438 (rank : 781)	θ value	5.27518 (rank : 383)
Query Neighborhood Hits	446	Target Neighborhood Hits	243	Shared Neighborhood Hits	28
SwissProt Accessions	Q62313	Gene names	Tgoln1, Ttgn1
Domain Architecture	No domain graphic available
Description	Trans-Golgi network integral membrane protein 1 precursor (TGN38A).

CE016_MOUSE
NC score	0.026896 (rank : 782)	θ value	1.81305 (rank : 270)
Query Neighborhood Hits	446	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BRJ3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C5orf16 homolog.

PTCD1_HUMAN
NC score	0.026771 (rank : 783)	θ value	1.38821 (rank : 260)
Query Neighborhood Hits	446	Target Neighborhood Hits	52	Shared Neighborhood Hits	7
SwissProt Accessions	O75127, Q66K60, Q9UDV2	Gene names	PTCD1, KIAA0632
Domain Architecture	No domain graphic available
Description	Pentatricopeptide repeat protein 1.

DCC_MOUSE
NC score	0.026177 (rank : 784)	θ value	0.21417 (rank : 170)
Query Neighborhood Hits	446	Target Neighborhood Hits	896	Shared Neighborhood Hits	68
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

SIA7A_HUMAN
NC score	0.025964 (rank : 785)	θ value	3.0926 (rank : 331)
Query Neighborhood Hits	446	Target Neighborhood Hits	177	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NSC7, Q6UW90, Q9NSC6	Gene names	ST6GALNAC1, SIAT7A
Domain Architecture
Description	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC 2.4.99.3) (GalNAc alpha-2,6-sialyltransferase I) (ST6GalNAc I) (Sialyltransferase 7A).

CLR59_HUMAN
NC score	0.025445 (rank : 786)	θ value	5.27518 (rank : 359)
Query Neighborhood Hits	446	Target Neighborhood Hits	163	Shared Neighborhood Hits	15
SwissProt Accessions	Q96DZ5, Q8WWL1, Q96C99, Q9UFT7	Gene names	CLIPR59
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 170-related 59 kDa protein (CLIPR-59) (CLIP-170-related 59 kDa protein).

MYOM2_HUMAN
NC score	0.024895 (rank : 787)	θ value	8.99809 (rank : 436)
Query Neighborhood Hits	446	Target Neighborhood Hits	341	Shared Neighborhood Hits	20
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

ATF4_HUMAN
NC score	0.024888 (rank : 788)	θ value	1.81305 (rank : 268)
Query Neighborhood Hits	446	Target Neighborhood Hits	110	Shared Neighborhood Hits	6
SwissProt Accessions	P18848, Q9UH31	Gene names	ATF4
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-4 (Activating transcription factor 4) (DNA-binding protein TAXREB67) (Cyclic AMP response element-binding protein 2) (CREB2).

GCNL2_MOUSE
NC score	0.024878 (rank : 789)	θ value	1.38821 (rank : 251)
Query Neighborhood Hits	446	Target Neighborhood Hits	146	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JHD2	Gene names	Gcn5l2
Domain Architecture
Description	General control of amino acid synthesis protein 5-like 2 (EC 2.3.1.48) (Histone acetyltransferase GCN5) (mmGCN5).

DCP1A_HUMAN
NC score	0.024577 (rank : 790)	θ value	6.88961 (rank : 391)
Query Neighborhood Hits	446	Target Neighborhood Hits	228	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NPI6	Gene names	DCP1A, SMIF
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 1A (EC 3.-.-.-) (Transcription factor SMIF) (Smad4-interacting transcriptional co-activator).

BRE1B_HUMAN
NC score	0.024490 (rank : 791)	θ value	1.38821 (rank : 248)
Query Neighborhood Hits	446	Target Neighborhood Hits	1040	Shared Neighborhood Hits	38
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

PSD4_HUMAN
NC score	0.023875 (rank : 792)	θ value	2.36792 (rank : 304)
Query Neighborhood Hits	446	Target Neighborhood Hits	178	Shared Neighborhood Hits	32
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

MUC15_HUMAN
NC score	0.023834 (rank : 793)	θ value	8.99809 (rank : 434)
Query Neighborhood Hits	446	Target Neighborhood Hits	61	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N387, Q6UWS3, Q8IXI8, Q8WW41	Gene names	MUC15
Domain Architecture	No domain graphic available
Description	Mucin-15 precursor.

NPAS4_MOUSE
NC score	0.023394 (rank : 794)	θ value	8.99809 (rank : 439)
Query Neighborhood Hits	446	Target Neighborhood Hits	245	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

PO6F1_MOUSE
NC score	0.023373 (rank : 795)	θ value	0.0736092 (rank : 135)
Query Neighborhood Hits	446	Target Neighborhood Hits	581	Shared Neighborhood Hits	32
SwissProt Accessions	Q07916, Q91XK3	Gene names	Pou6f1, Emb
Domain Architecture
Description	POU domain, class 6, transcription factor 1 (Octamer-binding transcription factor EMB) (Transcription regulatory protein MCP-1).

K1688_MOUSE
NC score	0.022228 (rank : 796)	θ value	8.99809 (rank : 430)
Query Neighborhood Hits	446	Target Neighborhood Hits	188	Shared Neighborhood Hits	27
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

PHLPP_HUMAN
NC score	0.021941 (rank : 797)	θ value	3.0926 (rank : 328)
Query Neighborhood Hits	446	Target Neighborhood Hits	604	Shared Neighborhood Hits	45
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

GNAS1_MOUSE
NC score	0.021593 (rank : 798)	θ value	6.88961 (rank : 397)
Query Neighborhood Hits	446	Target Neighborhood Hits	651	Shared Neighborhood Hits	69
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

NUCL_HUMAN
NC score	0.021272 (rank : 799)	θ value	0.813845 (rank : 227)
Query Neighborhood Hits	446	Target Neighborhood Hits	415	Shared Neighborhood Hits	25
SwissProt Accessions	P19338, Q53SK1, Q8NB06	Gene names	NCL
Domain Architecture
Description	Nucleolin (Protein C23).

CENPC_MOUSE
NC score	0.020938 (rank : 800)	θ value	4.03905 (rank : 337)
Query Neighborhood Hits	446	Target Neighborhood Hits	154	Shared Neighborhood Hits	15
SwissProt Accessions	P49452	Gene names	Cenpc1, Cenpc
Domain Architecture	No domain graphic available
Description	Centromere protein C 1 (CENP-C) (Centromere autoantigen C).

CI066_HUMAN
NC score	0.019825 (rank : 801)	θ value	6.88961 (rank : 387)
Query Neighborhood Hits	446	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	Q5T8R8, Q96NB0	Gene names	C9orf66
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf66.

NUCL_MOUSE
NC score	0.019527 (rank : 802)	θ value	1.81305 (rank : 282)
Query Neighborhood Hits	446	Target Neighborhood Hits	425	Shared Neighborhood Hits	20
SwissProt Accessions	P09405, Q548M9, Q61991, Q99K50	Gene names	Ncl, Nuc
Domain Architecture
Description	Nucleolin (Protein C23).

PLXB1_MOUSE
NC score	0.019514 (rank : 803)	θ value	0.47712 (rank : 202)
Query Neighborhood Hits	446	Target Neighborhood Hits	259	Shared Neighborhood Hits	28
SwissProt Accessions	Q8CJH3, Q6ZQC3, Q80ZZ1	Gene names	Plxnb1, Kiaa0407
Domain Architecture	No domain graphic available
Description	Plexin-B1 precursor.

CO7A1_HUMAN
NC score	0.019450 (rank : 804)	θ value	6.88961 (rank : 389)
Query Neighborhood Hits	446	Target Neighborhood Hits	807	Shared Neighborhood Hits	70
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

RPC62_MOUSE
NC score	0.019227 (rank : 805)	θ value	3.0926 (rank : 330)
Query Neighborhood Hits	446	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D483, Q8R0I2	Gene names	Polr3c, Rpc62
Domain Architecture
Description	DNA-directed RNA polymerase III 62 kDa polypeptide (EC 2.7.7.6) (RNA polymerase C subunit 3) (RPC3) (RNA polymerase III C62 subunit).

PGCA_HUMAN
NC score	0.019207 (rank : 806)	θ value	3.0926 (rank : 327)
Query Neighborhood Hits	446	Target Neighborhood Hits	821	Shared Neighborhood Hits	51
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

DAB2_HUMAN
NC score	0.019204 (rank : 807)	θ value	8.99809 (rank : 423)
Query Neighborhood Hits	446	Target Neighborhood Hits	197	Shared Neighborhood Hits	30
SwissProt Accessions	P98082, Q13598, Q9BTY0, Q9UK04	Gene names	DAB2, DOC2
Domain Architecture
Description	Disabled homolog 2 (Differentially expressed protein 2) (DOC-2).

PER2_HUMAN
NC score	0.019143 (rank : 808)	θ value	1.81305 (rank : 284)
Query Neighborhood Hits	446	Target Neighborhood Hits	170	Shared Neighborhood Hits	24
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

EKI1_HUMAN
NC score	0.019018 (rank : 809)	θ value	2.36792 (rank : 295)
Query Neighborhood Hits	446	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HBU6	Gene names	ETNK1, EKI1
Domain Architecture
Description	Ethanolamine kinase 1 (EC 2.7.1.82) (EKI 1).

NSD1_MOUSE
NC score	0.018740 (rank : 810)	θ value	8.99809 (rank : 440)
Query Neighborhood Hits	446	Target Neighborhood Hits	472	Shared Neighborhood Hits	43
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

UBTD2_HUMAN
NC score	0.018362 (rank : 811)	θ value	4.03905 (rank : 355)
Query Neighborhood Hits	446	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WUN7, Q8TDQ3	Gene names	UBTD2, DCUBP
Domain Architecture	No domain graphic available
Description	Ubiquitin domain-containing protein 2 (Dendritic cell-derived ubiquitin-like protein) (DC-UbP) (Ubiquitin-like protein SB72).

NBEA_MOUSE
NC score	0.018355 (rank : 812)	θ value	3.0926 (rank : 324)
Query Neighborhood Hits	446	Target Neighborhood Hits	225	Shared Neighborhood Hits	17
SwissProt Accessions	Q9EPN1, Q8C931, Q9EPM9, Q9EPN0, Q9WVM9	Gene names	Nbea, Lyst2
Domain Architecture
Description	Protein neurobeachin (Lysosomal-trafficking regulator 2).

REST_MOUSE
NC score	0.017811 (rank : 813)	θ value	1.38821 (rank : 261)
Query Neighborhood Hits	446	Target Neighborhood Hits	1506	Shared Neighborhood Hits	56
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

CAC1H_HUMAN
NC score	0.017775 (rank : 814)	θ value	3.0926 (rank : 311)
Query Neighborhood Hits	446	Target Neighborhood Hits	307	Shared Neighborhood Hits	33
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

EPN2_HUMAN
NC score	0.017430 (rank : 815)	θ value	8.99809 (rank : 425)
Query Neighborhood Hits	446	Target Neighborhood Hits	156	Shared Neighborhood Hits	22
SwissProt Accessions	O95208, O95207, Q9H7Z2, Q9UPT7	Gene names	EPN2, KIAA1065
Domain Architecture
Description	Epsin-2 (EPS-15-interacting protein 2).

TNR8_MOUSE
NC score	0.016452 (rank : 816)	θ value	4.03905 (rank : 354)
Query Neighborhood Hits	446	Target Neighborhood Hits	208	Shared Neighborhood Hits	12
SwissProt Accessions	Q60846	Gene names	Tnfrsf8
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 8 precursor (CD30L receptor) (Lymphocyte activation antigen CD30).

LRC41_HUMAN
NC score	0.015832 (rank : 817)	θ value	5.27518 (rank : 366)
Query Neighborhood Hits	446	Target Neighborhood Hits	51	Shared Neighborhood Hits	9
SwissProt Accessions	Q15345, Q71RA8, Q9BSM0	Gene names	LRRC41, MUF1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 41 (Protein Muf1).

UBTD2_MOUSE
NC score	0.015790 (rank : 818)	θ value	6.88961 (rank : 414)
Query Neighborhood Hits	446	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PGH0, Q8C5Y1	Gene names	Ubtd2
Domain Architecture	No domain graphic available
Description	Ubiquitin domain-containing protein 2.

SCML2_HUMAN
NC score	0.015725 (rank : 819)	θ value	6.88961 (rank : 408)
Query Neighborhood Hits	446	Target Neighborhood Hits	68	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UQR0, Q86U98, Q8IWD0, Q8NDP2, Q9UGC5	Gene names	SCML2
Domain Architecture
Description	Sex comb on midleg-like protein 2.

PRGC1_HUMAN
NC score	0.015690 (rank : 820)	θ value	5.27518 (rank : 372)
Query Neighborhood Hits	446	Target Neighborhood Hits	157	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UBK2, Q9UN32	Gene names	PPARGC1A, LEM6, PGC1, PGC1A, PPARGC1
Domain Architecture
Description	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPAR gamma coactivator 1-alpha) (PPARGC-1-alpha) (PGC-1-alpha) (Ligand effect modulator 6).

TENX_HUMAN
NC score	0.015623 (rank : 821)	θ value	0.21417 (rank : 179)
Query Neighborhood Hits	446	Target Neighborhood Hits	789	Shared Neighborhood Hits	45
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

NMDE3_MOUSE
NC score	0.015526 (rank : 822)	θ value	0.62314 (rank : 214)
Query Neighborhood Hits	446	Target Neighborhood Hits	86	Shared Neighborhood Hits	12
SwissProt Accessions	Q01098	Gene names	Grin2c
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 3 precursor (N-methyl D- aspartate receptor subtype 2C) (NR2C) (NMDAR2C).

E2F2_MOUSE
NC score	0.013912 (rank : 823)	θ value	5.27518 (rank : 360)
Query Neighborhood Hits	446	Target Neighborhood Hits	42	Shared Neighborhood Hits	6
SwissProt Accessions	P56931, Q8BID0	Gene names	E2f2
Domain Architecture	No domain graphic available
Description	Transcription factor E2F2 (E2F-2).

PCOC1_HUMAN
NC score	0.012922 (rank : 824)	θ value	4.03905 (rank : 348)
Query Neighborhood Hits	446	Target Neighborhood Hits	146	Shared Neighborhood Hits	14
SwissProt Accessions	Q15113, O14550	Gene names	PCOLCE, PCPE1
Domain Architecture
Description	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein).

NCOA1_MOUSE
NC score	0.011943 (rank : 825)	θ value	8.99809 (rank : 437)
Query Neighborhood Hits	446	Target Neighborhood Hits	196	Shared Neighborhood Hits	18
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

DMXL2_HUMAN
NC score	0.011740 (rank : 826)	θ value	6.88961 (rank : 393)
Query Neighborhood Hits	446	Target Neighborhood Hits	374	Shared Neighborhood Hits	13
SwissProt Accessions	Q8TDJ6, O94938	Gene names	DMXL2, KIAA0856
Domain Architecture	No domain graphic available
Description	Protein DmX-like 2 (Rabconnectin-3).

ZDHC8_MOUSE
NC score	0.011740 (rank : 827)	θ value	5.27518 (rank : 385)
Query Neighborhood Hits	446	Target Neighborhood Hits	243	Shared Neighborhood Hits	27
SwissProt Accessions	Q5Y5T5, Q7TNF7	Gene names	Zdhhc8
Domain Architecture	No domain graphic available
Description	Probable palmitoyltransferase ZDHHC8 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 8) (DHHC-8).

KCNH6_HUMAN
NC score	0.011732 (rank : 828)	θ value	8.99809 (rank : 431)
Query Neighborhood Hits	446	Target Neighborhood Hits	222	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

GAK12_HUMAN
NC score	0.011514 (rank : 829)	θ value	5.27518 (rank : 361)
Query Neighborhood Hits	446	Target Neighborhood Hits	374	Shared Neighborhood Hits	24
SwissProt Accessions	P63130, Q9UKI0	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q22 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K102 Gag protein) (HERV-K(III) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

BRD8_HUMAN
NC score	0.011014 (rank : 830)	θ value	6.88961 (rank : 386)
Query Neighborhood Hits	446	Target Neighborhood Hits	292	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H0E9, O43178, Q15355, Q59GN0, Q969M9	Gene names	BRD8, SMAP
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8 (p120) (Skeletal muscle abundant protein) (Thyroid hormone receptor coactivating protein 120kDa) (TrCP120).

GAK2_HUMAN
NC score	0.010867 (rank : 831)	θ value	6.88961 (rank : 396)
Query Neighborhood Hits	446	Target Neighborhood Hits	406	Shared Neighborhood Hits	26
SwissProt Accessions	Q7LDI9, Q9UKH5, Q9Y6I1, Q9YNA6, Q9YNB0	Gene names	ERVK6
Domain Architecture	No domain graphic available
Description	HERV-K_7p22.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K(C7) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK4_HUMAN
NC score	0.010605 (rank : 832)	θ value	8.99809 (rank : 428)
Query Neighborhood Hits	446	Target Neighborhood Hits	415	Shared Neighborhood Hits	26
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK11_HUMAN
NC score	0.010591 (rank : 833)	θ value	8.99809 (rank : 427)
Query Neighborhood Hits	446	Target Neighborhood Hits	409	Shared Neighborhood Hits	26
SwissProt Accessions	P63145, Q9UKI1	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_22q11.21 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K101 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

TBCD4_HUMAN
NC score	0.010136 (rank : 834)	θ value	6.88961 (rank : 413)
Query Neighborhood Hits	446	Target Neighborhood Hits	357	Shared Neighborhood Hits	16
SwissProt Accessions	O60343, Q5W0B9	Gene names	TBC1D4, KIAA0603
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160).

TSH2_HUMAN
NC score	0.009765 (rank : 835)	θ value	3.0926 (rank : 334)
Query Neighborhood Hits	446	Target Neighborhood Hits	479	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NRE2, Q4VXM4, Q6N003, Q8N260	Gene names	TSHZ2, C20orf17, TSH2, ZNF218
Domain Architecture	No domain graphic available
Description	Teashirt homolog 2 (Zinc finger protein 218) (Ovarian cancer-related protein 10-2) (OVC10-2).

C1QR1_HUMAN
NC score	0.009353 (rank : 836)	θ value	0.279714 (rank : 184)
Query Neighborhood Hits	446	Target Neighborhood Hits	493	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NPY3, O00274	Gene names	CD93, C1QR1, MXRA4
Domain Architecture
Description	Complement component C1q receptor precursor (Complement component 1 q subcomponent receptor 1) (C1qR) (C1qRp) (C1qR(p)) (C1q/MBL/SPA receptor) (CD93 antigen) (CDw93).

TRFM_HUMAN
NC score	0.009177 (rank : 837)	θ value	5.27518 (rank : 384)
Query Neighborhood Hits	446	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	P08582, Q9BQE2	Gene names	MFI2, MAP97
Domain Architecture
Description	Melanotransferrin precursor (Melanoma-associated antigen p97) (CD228 antigen).

NOG2_MOUSE
NC score	0.009170 (rank : 838)	θ value	8.99809 (rank : 438)
Query Neighborhood Hits	446	Target Neighborhood Hits	71	Shared Neighborhood Hits	7
SwissProt Accessions	Q99LH1, Q8BIF8	Gene names	Gnl2
Domain Architecture	No domain graphic available
Description	Nucleolar GTP-binding protein 2.

ECM2_HUMAN
NC score	0.008772 (rank : 839)	θ value	2.36792 (rank : 294)
Query Neighborhood Hits	446	Target Neighborhood Hits	402	Shared Neighborhood Hits	9
SwissProt Accessions	O94769	Gene names	ECM2
Domain Architecture
Description	Extracellular matrix protein 2 precursor (Matrix glycoprotein SC1/ECM2).

RARA_HUMAN
NC score	0.005363 (rank : 840)	θ value	4.03905 (rank : 350)
Query Neighborhood Hits	446	Target Neighborhood Hits	118	Shared Neighborhood Hits	4
SwissProt Accessions	P10276, P78456, Q13440, Q13441, Q9NQS0	Gene names	RARA, NR1B1
Domain Architecture
Description	Retinoic acid receptor alpha (RAR-alpha).

TBX18_HUMAN
NC score	0.005337 (rank : 841)	θ value	8.99809 (rank : 443)
Query Neighborhood Hits	446	Target Neighborhood Hits	148	Shared Neighborhood Hits	11
SwissProt Accessions	O95935, Q7Z6U4, Q9UJI6	Gene names	TBX18
Domain Architecture
Description	T-box transcription factor TBX18 (T-box protein 18).

RARA_MOUSE
NC score	0.004968 (rank : 842)	θ value	5.27518 (rank : 374)
Query Neighborhood Hits	446	Target Neighborhood Hits	113	Shared Neighborhood Hits	4
SwissProt Accessions	P11416, P22603	Gene names	Rara, Nr1b1
Domain Architecture
Description	Retinoic acid receptor alpha (RAR-alpha).

ZDHC6_HUMAN
NC score	0.004932 (rank : 843)	θ value	8.99809 (rank : 446)
Query Neighborhood Hits	446	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H6R6, Q53G45, Q96IV7, Q9H605	Gene names	ZDHHC6, ZNF376
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC6 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 6) (DHHC-6) (Zinc finger protein 376) (Transmembrane protein H4).

TRPV4_HUMAN
NC score	0.004220 (rank : 844)	θ value	8.99809 (rank : 444)
Query Neighborhood Hits	446	Target Neighborhood Hits	150	Shared Neighborhood Hits	8
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

SC6A5_MOUSE
NC score	0.003221 (rank : 845)	θ value	6.88961 (rank : 407)
Query Neighborhood Hits	446	Target Neighborhood Hits	135	Shared Neighborhood Hits	21
SwissProt Accessions	Q761V0, Q8CFM5, Q91ZQ2	Gene names	Slc6a5, Glyt2
Domain Architecture	No domain graphic available
Description	Sodium- and chloride-dependent glycine transporter 2 (GlyT2) (GlyT-2) (Solute carrier family 6 member 5).

MSX1_HUMAN
NC score	0.001983 (rank : 846)	θ value	3.0926 (rank : 321)
Query Neighborhood Hits	446	Target Neighborhood Hits	374	Shared Neighborhood Hits	8
SwissProt Accessions	P28360, Q96NY4	Gene names	MSX1, HOX7
Domain Architecture
Description	Homeobox protein MSX-1 (Msh homeobox 1-like protein) (Hox-7).

BARH2_MOUSE
NC score	0.001408 (rank : 847)	θ value	4.03905 (rank : 335)
Query Neighborhood Hits	446	Target Neighborhood Hits	397	Shared Neighborhood Hits	16
SwissProt Accessions	Q8VIB5, Q66L43	Gene names	Barhl2, Barh1, Mbh1
Domain Architecture	No domain graphic available
Description	BarH-like 2 homeobox protein (Bar-class homeodomain protein MBH1) (Homeobox protein B-H1).

PC11X_HUMAN
NC score	0.000862 (rank : 848)	θ value	1.38821 (rank : 258)
Query Neighborhood Hits	446	Target Neighborhood Hits	199	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BZA7, Q2TJH0, Q2TJH1, Q2TJH3, Q5JVZ0, Q70LR8, Q70LS7, Q70LS8, Q70LS9, Q70LT7, Q70LT8, Q70LT9, Q70LU0, Q70LU1, Q96RV4, Q96RW0, Q9BZA6, Q9H4E0, Q9P2M0, Q9P2X5	Gene names	PCDH11X, PCDH11, PCDHX
Domain Architecture	No domain graphic available
Description	Protocadherin-11 X-linked precursor (Protocadherin-11) (Protocadherin on the X chromosome) (PCDH-X) (Protocadherin-S).

ST14_MOUSE
NC score	0.000340 (rank : 849)	θ value	1.81305 (rank : 288)
Query Neighborhood Hits	446	Target Neighborhood Hits	419	Shared Neighborhood Hits	6
SwissProt Accessions	P56677	Gene names	St14, Prss14
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Epithin).

LPHN3_HUMAN
NC score	-0.000024 (rank : 850)	θ value	8.99809 (rank : 433)
Query Neighborhood Hits	446	Target Neighborhood Hits	139	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HAR2, O94867, Q9NWK5	Gene names	LPHN3, KIAA0768, LEC3
Domain Architecture
Description	Latrophilin-3 precursor (Calcium-independent alpha-latrotoxin receptor 3) (Lectomedin-3).

ST14_HUMAN
NC score	-0.000677 (rank : 851)	θ value	5.27518 (rank : 381)
Query Neighborhood Hits	446	Target Neighborhood Hits	409	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y5Y6, Q9BS01, Q9H3S0, Q9HB36, Q9HCA3	Gene names	ST14, PRSS14, SNC19, TADG15
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein).

SALL1_MOUSE
NC score	-0.006524 (rank : 852)	θ value	6.88961 (rank : 406)
Query Neighborhood Hits	446	Target Neighborhood Hits	826	Shared Neighborhood Hits	16
SwissProt Accessions	Q9ER74, Q920R5	Gene names	Sall1, Sal3
Domain Architecture
Description	Sal-like protein 1 (Zinc finger protein Spalt-3) (Sal-3) (MSal-3).

MTF1_HUMAN
NC score	-0.006843 (rank : 853)	θ value	2.36792 (rank : 299)
Query Neighborhood Hits	446	Target Neighborhood Hits	814	Shared Neighborhood Hits	23
SwissProt Accessions	Q14872, Q96CB1	Gene names	MTF1
Domain Architecture	No domain graphic available
Description	Metal-regulatory transcription factor 1 (Transcription factor MTF-1) (MRE-binding transcription factor).