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Network neighborhood for query Sequence : PDZD8_HUMAN

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PDZD8_HUMAN
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PDZD8_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	185	Target Neighborhood Hits	185	Shared Neighborhood Hits	185
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

KPCE_HUMAN
θ value	0.00020696 (rank : 2)	NC score	0.178636 (rank : 29)
Query Neighborhood Hits	185	Target Neighborhood Hits	906	Shared Neighborhood Hits	72
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCE_MOUSE
θ value	0.00020696 (rank : 3)	NC score	0.178171 (rank : 30)
Query Neighborhood Hits	185	Target Neighborhood Hits	906	Shared Neighborhood Hits	70
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCL_HUMAN
θ value	0.000270298 (rank : 4)	NC score	0.177182 (rank : 31)
Query Neighborhood Hits	185	Target Neighborhood Hits	887	Shared Neighborhood Hits	70
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KPCL_MOUSE
θ value	0.000270298 (rank : 5)	NC score	0.174902 (rank : 34)
Query Neighborhood Hits	185	Target Neighborhood Hits	891	Shared Neighborhood Hits	71
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KPCD1_HUMAN
θ value	0.000461057 (rank : 6)	NC score	0.140726 (rank : 64)
Query Neighborhood Hits	185	Target Neighborhood Hits	901	Shared Neighborhood Hits	70
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

PDZD1_HUMAN
θ value	0.000602161 (rank : 7)	NC score	0.221349 (rank : 17)
Query Neighborhood Hits	185	Target Neighborhood Hits	190	Shared Neighborhood Hits	44
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

KPCB_HUMAN
θ value	0.000786445 (rank : 8)	NC score	0.175345 (rank : 32)
Query Neighborhood Hits	185	Target Neighborhood Hits	1121	Shared Neighborhood Hits	70
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_MOUSE
θ value	0.000786445 (rank : 9)	NC score	0.175017 (rank : 33)
Query Neighborhood Hits	185	Target Neighborhood Hits	1117	Shared Neighborhood Hits	70
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCT_HUMAN
θ value	0.000786445 (rank : 10)	NC score	0.170286 (rank : 43)
Query Neighborhood Hits	185	Target Neighborhood Hits	897	Shared Neighborhood Hits	69
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPCT_MOUSE
θ value	0.000786445 (rank : 11)	NC score	0.170553 (rank : 42)
Query Neighborhood Hits	185	Target Neighborhood Hits	895	Shared Neighborhood Hits	69
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

IWS1_MOUSE
θ value	0.00102713 (rank : 12)	NC score	0.086024 (rank : 317)
Query Neighborhood Hits	185	Target Neighborhood Hits	1258	Shared Neighborhood Hits	34
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

KPCD1_MOUSE
θ value	0.00102713 (rank : 13)	NC score	0.140124 (rank : 67)
Query Neighborhood Hits	185	Target Neighborhood Hits	891	Shared Neighborhood Hits	70
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

RASF1_MOUSE
θ value	0.00102713 (rank : 14)	NC score	0.337835 (rank : 2)
Query Neighborhood Hits	185	Target Neighborhood Hits	74	Shared Neighborhood Hits	52
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

KPCA_HUMAN
θ value	0.00134147 (rank : 15)	NC score	0.170704 (rank : 41)
Query Neighborhood Hits	185	Target Neighborhood Hits	1070	Shared Neighborhood Hits	72
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCA_MOUSE
θ value	0.00134147 (rank : 16)	NC score	0.170282 (rank : 44)
Query Neighborhood Hits	185	Target Neighborhood Hits	1067	Shared Neighborhood Hits	72
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCD3_HUMAN
θ value	0.00134147 (rank : 17)	NC score	0.145678 (rank : 58)
Query Neighborhood Hits	185	Target Neighborhood Hits	895	Shared Neighborhood Hits	71
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

KPCG_HUMAN
θ value	0.00134147 (rank : 18)	NC score	0.173716 (rank : 37)
Query Neighborhood Hits	185	Target Neighborhood Hits	1126	Shared Neighborhood Hits	72
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCG_MOUSE
θ value	0.00134147 (rank : 19)	NC score	0.173654 (rank : 38)
Query Neighborhood Hits	185	Target Neighborhood Hits	1123	Shared Neighborhood Hits	72
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCD3_MOUSE
θ value	0.00175202 (rank : 20)	NC score	0.142588 (rank : 59)
Query Neighborhood Hits	185	Target Neighborhood Hits	901	Shared Neighborhood Hits	73
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

KPCD_HUMAN
θ value	0.00175202 (rank : 21)	NC score	0.174040 (rank : 36)
Query Neighborhood Hits	185	Target Neighborhood Hits	900	Shared Neighborhood Hits	72
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

MYO9B_MOUSE
θ value	0.00175202 (rank : 22)	NC score	0.115087 (rank : 130)
Query Neighborhood Hits	185	Target Neighborhood Hits	311	Shared Neighborhood Hits	63
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

CHIN_HUMAN
θ value	0.00228821 (rank : 23)	NC score	0.269235 (rank : 10)
Query Neighborhood Hits	185	Target Neighborhood Hits	227	Shared Neighborhood Hits	57
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

KPCD_MOUSE
θ value	0.00228821 (rank : 24)	NC score	0.174119 (rank : 35)
Query Neighborhood Hits	185	Target Neighborhood Hits	888	Shared Neighborhood Hits	72
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

CHIN_MOUSE
θ value	0.00298849 (rank : 25)	NC score	0.268779 (rank : 11)
Query Neighborhood Hits	185	Target Neighborhood Hits	229	Shared Neighborhood Hits	57
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	0.00298849 (rank : 26)	NC score	0.273291 (rank : 9)
Query Neighborhood Hits	185	Target Neighborhood Hits	220	Shared Neighborhood Hits	57
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

GRP3_HUMAN
θ value	0.00298849 (rank : 27)	NC score	0.334899 (rank : 3)
Query Neighborhood Hits	185	Target Neighborhood Hits	131	Shared Neighborhood Hits	61
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

PDZD1_MOUSE
θ value	0.00298849 (rank : 28)	NC score	0.215900 (rank : 18)
Query Neighborhood Hits	185	Target Neighborhood Hits	191	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

CHIO_MOUSE
θ value	0.00665767 (rank : 29)	NC score	0.278954 (rank : 6)
Query Neighborhood Hits	185	Target Neighborhood Hits	130	Shared Neighborhood Hits	57
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

DGKG_MOUSE
θ value	0.00665767 (rank : 30)	NC score	0.211804 (rank : 19)
Query Neighborhood Hits	185	Target Neighborhood Hits	188	Shared Neighborhood Hits	54
SwissProt Accessions	Q91WG7	Gene names	Dgkg, Dagk3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma) (88 kDa diacylglycerol kinase).

3BP2_HUMAN
θ value	0.00869519 (rank : 31)	NC score	0.093056 (rank : 235)
Query Neighborhood Hits	185	Target Neighborhood Hits	296	Shared Neighborhood Hits	11
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

DLG3_HUMAN
θ value	0.00869519 (rank : 32)	NC score	0.150733 (rank : 54)
Query Neighborhood Hits	185	Target Neighborhood Hits	269	Shared Neighborhood Hits	45
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG3_MOUSE
θ value	0.00869519 (rank : 33)	NC score	0.151167 (rank : 53)
Query Neighborhood Hits	185	Target Neighborhood Hits	274	Shared Neighborhood Hits	45
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

DGKQ_HUMAN
θ value	0.0148317 (rank : 34)	NC score	0.264731 (rank : 12)
Query Neighborhood Hits	185	Target Neighborhood Hits	131	Shared Neighborhood Hits	60
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

KPCD2_HUMAN
θ value	0.0252991 (rank : 35)	NC score	0.136377 (rank : 72)
Query Neighborhood Hits	185	Target Neighborhood Hits	910	Shared Neighborhood Hits	70
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

DLG1_HUMAN
θ value	0.0330416 (rank : 36)	NC score	0.147306 (rank : 56)
Query Neighborhood Hits	185	Target Neighborhood Hits	290	Shared Neighborhood Hits	41
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

DLG1_MOUSE
θ value	0.0330416 (rank : 37)	NC score	0.148548 (rank : 55)
Query Neighborhood Hits	185	Target Neighborhood Hits	285	Shared Neighborhood Hits	42
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

UN13B_MOUSE
θ value	0.0330416 (rank : 38)	NC score	0.275824 (rank : 8)
Query Neighborhood Hits	185	Target Neighborhood Hits	210	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

MYO9B_HUMAN
θ value	0.0431538 (rank : 39)	NC score	0.111655 (rank : 156)
Query Neighborhood Hits	185	Target Neighborhood Hits	641	Shared Neighborhood Hits	79
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

NHRF2_HUMAN
θ value	0.0431538 (rank : 40)	NC score	0.191378 (rank : 23)
Query Neighborhood Hits	185	Target Neighborhood Hits	197	Shared Neighborhood Hits	46
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

NHRF2_MOUSE
θ value	0.0431538 (rank : 41)	NC score	0.188319 (rank : 26)
Query Neighborhood Hits	185	Target Neighborhood Hits	194	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

RASF5_MOUSE
θ value	0.0431538 (rank : 42)	NC score	0.203911 (rank : 20)
Query Neighborhood Hits	185	Target Neighborhood Hits	72	Shared Neighborhood Hits	46
SwissProt Accessions	Q5EBH1, O70407, Q6KAR0, Q8C2E8	Gene names	Rassf5, Nore1, Rapl
Domain Architecture	No domain graphic available
Description	Ras association domain-containing family protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL).

KPCZ_MOUSE
θ value	0.0563607 (rank : 43)	NC score	0.160392 (rank : 47)
Query Neighborhood Hits	185	Target Neighborhood Hits	882	Shared Neighborhood Hits	70
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

UN13A_HUMAN
θ value	0.0563607 (rank : 44)	NC score	0.284804 (rank : 5)
Query Neighborhood Hits	185	Target Neighborhood Hits	285	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

ARHGC_HUMAN
θ value	0.0736092 (rank : 45)	NC score	0.130443 (rank : 78)
Query Neighborhood Hits	185	Target Neighborhood Hits	351	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

IWS1_HUMAN
θ value	0.0736092 (rank : 46)	NC score	0.074625 (rank : 488)
Query Neighborhood Hits	185	Target Neighborhood Hits	1241	Shared Neighborhood Hits	33
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

KPCZ_HUMAN
θ value	0.0736092 (rank : 47)	NC score	0.160781 (rank : 46)
Query Neighborhood Hits	185	Target Neighborhood Hits	884	Shared Neighborhood Hits	71
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

ARHGB_HUMAN
θ value	0.0961366 (rank : 48)	NC score	0.127463 (rank : 84)
Query Neighborhood Hits	185	Target Neighborhood Hits	375	Shared Neighborhood Hits	55
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

STAC_HUMAN
θ value	0.0961366 (rank : 49)	NC score	0.226783 (rank : 16)
Query Neighborhood Hits	185	Target Neighborhood Hits	276	Shared Neighborhood Hits	56
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

UN13B_HUMAN
θ value	0.0961366 (rank : 50)	NC score	0.277327 (rank : 7)
Query Neighborhood Hits	185	Target Neighborhood Hits	217	Shared Neighborhood Hits	64
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

KPCI_HUMAN
θ value	0.125558 (rank : 51)	NC score	0.154034 (rank : 50)
Query Neighborhood Hits	185	Target Neighborhood Hits	885	Shared Neighborhood Hits	68
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

KPCI_MOUSE
θ value	0.125558 (rank : 52)	NC score	0.154320 (rank : 49)
Query Neighborhood Hits	185	Target Neighborhood Hits	888	Shared Neighborhood Hits	70
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

ARHGC_MOUSE
θ value	0.163984 (rank : 53)	NC score	0.125498 (rank : 86)
Query Neighborhood Hits	185	Target Neighborhood Hits	344	Shared Neighborhood Hits	54
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

DLG2_HUMAN
θ value	0.163984 (rank : 54)	NC score	0.142530 (rank : 60)
Query Neighborhood Hits	185	Target Neighborhood Hits	279	Shared Neighborhood Hits	45
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG2_MOUSE
θ value	0.163984 (rank : 55)	NC score	0.142387 (rank : 61)
Query Neighborhood Hits	185	Target Neighborhood Hits	271	Shared Neighborhood Hits	45
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

PDZD3_HUMAN
θ value	0.163984 (rank : 56)	NC score	0.190550 (rank : 24)
Query Neighborhood Hits	185	Target Neighborhood Hits	180	Shared Neighborhood Hits	43
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

RGS3_MOUSE
θ value	0.163984 (rank : 57)	NC score	0.060942 (rank : 731)
Query Neighborhood Hits	185	Target Neighborhood Hits	1621	Shared Neighborhood Hits	65
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

STAC_MOUSE
θ value	0.163984 (rank : 58)	NC score	0.232500 (rank : 13)
Query Neighborhood Hits	185	Target Neighborhood Hits	268	Shared Neighborhood Hits	61
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

WHRN_MOUSE
θ value	0.163984 (rank : 59)	NC score	0.152476 (rank : 52)
Query Neighborhood Hits	185	Target Neighborhood Hits	412	Shared Neighborhood Hits	54
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

DGKG_HUMAN
θ value	0.21417 (rank : 60)	NC score	0.202009 (rank : 21)
Query Neighborhood Hits	185	Target Neighborhood Hits	171	Shared Neighborhood Hits	56
SwissProt Accessions	P49619	Gene names	DGKG, DAGK3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma).

RASF1_HUMAN
θ value	0.21417 (rank : 61)	NC score	0.285358 (rank : 4)
Query Neighborhood Hits	185	Target Neighborhood Hits	62	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NS23, O14571, O60539, O60710, Q9HB04, Q9HB18, Q9NS22, Q9UND4, Q9UND5	Gene names	RASSF1, RDA32
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1.

SDCB1_MOUSE
θ value	0.21417 (rank : 62)	NC score	0.159847 (rank : 48)
Query Neighborhood Hits	185	Target Neighborhood Hits	144	Shared Neighborhood Hits	44
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

ASPP1_MOUSE
θ value	0.279714 (rank : 63)	NC score	0.046156 (rank : 907)
Query Neighborhood Hits	185	Target Neighborhood Hits	1244	Shared Neighborhood Hits	47
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

MAST1_HUMAN
θ value	0.279714 (rank : 64)	NC score	0.141644 (rank : 62)
Query Neighborhood Hits	185	Target Neighborhood Hits	1146	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST4_HUMAN
θ value	0.279714 (rank : 65)	NC score	0.141142 (rank : 63)
Query Neighborhood Hits	185	Target Neighborhood Hits	1804	Shared Neighborhood Hits	95
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MYF6_MOUSE
θ value	0.279714 (rank : 66)	NC score	0.048797 (rank : 906)
Query Neighborhood Hits	185	Target Neighborhood Hits	72	Shared Neighborhood Hits	2
SwissProt Accessions	P15375	Gene names	Myf6, Myf-6
Domain Architecture
Description	Myogenic factor 6 (Myf-6) (Herculin).

NFH_MOUSE
θ value	0.279714 (rank : 67)	NC score	0.028681 (rank : 926)
Query Neighborhood Hits	185	Target Neighborhood Hits	2247	Shared Neighborhood Hits	58
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

RASF5_HUMAN
θ value	0.279714 (rank : 68)	NC score	0.190341 (rank : 25)
Query Neighborhood Hits	185	Target Neighborhood Hits	79	Shared Neighborhood Hits	44
SwissProt Accessions	Q8WWW0, Q5SY32, Q8WWV9, Q8WXF4, Q9BT99	Gene names	RASSF5, NORE1, RAPL
Domain Architecture	No domain graphic available
Description	Ras association domain-containing family protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL).

ROCK2_MOUSE
θ value	0.279714 (rank : 69)	NC score	0.118772 (rank : 107)
Query Neighborhood Hits	185	Target Neighborhood Hits	2072	Shared Neighborhood Hits	72
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

SYTL2_MOUSE
θ value	0.279714 (rank : 70)	NC score	0.069042 (rank : 596)
Query Neighborhood Hits	185	Target Neighborhood Hits	253	Shared Neighborhood Hits	18
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

ZCH14_HUMAN
θ value	0.279714 (rank : 71)	NC score	0.058736 (rank : 775)
Query Neighborhood Hits	185	Target Neighborhood Hits	117	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WYQ9, O60324, Q9UFP0	Gene names	ZCCHC14, KIAA0579
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 14 (BDG-29).

CF152_HUMAN
θ value	0.365318 (rank : 72)	NC score	0.055522 (rank : 830)
Query Neighborhood Hits	185	Target Neighborhood Hits	704	Shared Neighborhood Hits	26
SwissProt Accessions	Q86VQ0, Q9BWX7	Gene names	C6orf152
Domain Architecture	No domain graphic available
Description	Protein C6orf152.

STAC3_HUMAN
θ value	0.365318 (rank : 73)	NC score	0.231302 (rank : 14)
Query Neighborhood Hits	185	Target Neighborhood Hits	228	Shared Neighborhood Hits	57
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ACK1_HUMAN
θ value	0.47712 (rank : 74)	NC score	0.060457 (rank : 743)
Query Neighborhood Hits	185	Target Neighborhood Hits	1140	Shared Neighborhood Hits	62
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

INADL_MOUSE
θ value	0.47712 (rank : 75)	NC score	0.129692 (rank : 79)
Query Neighborhood Hits	185	Target Neighborhood Hits	290	Shared Neighborhood Hits	48
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

MAST2_MOUSE
θ value	0.47712 (rank : 76)	NC score	0.138582 (rank : 70)
Query Neighborhood Hits	185	Target Neighborhood Hits	1110	Shared Neighborhood Hits	75
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MRCKB_MOUSE
θ value	0.47712 (rank : 77)	NC score	0.132241 (rank : 75)
Query Neighborhood Hits	185	Target Neighborhood Hits	2180	Shared Neighborhood Hits	95
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

PZRN3_MOUSE
θ value	0.47712 (rank : 78)	NC score	0.113279 (rank : 138)
Query Neighborhood Hits	185	Target Neighborhood Hits	447	Shared Neighborhood Hits	48
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

ROCK2_HUMAN
θ value	0.47712 (rank : 79)	NC score	0.118318 (rank : 109)
Query Neighborhood Hits	185	Target Neighborhood Hits	2073	Shared Neighborhood Hits	74
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

SDCB1_HUMAN
θ value	0.47712 (rank : 80)	NC score	0.152481 (rank : 51)
Query Neighborhood Hits	185	Target Neighborhood Hits	150	Shared Neighborhood Hits	44
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

LIPA1_HUMAN
θ value	0.62314 (rank : 81)	NC score	0.032846 (rank : 919)
Query Neighborhood Hits	185	Target Neighborhood Hits	1294	Shared Neighborhood Hits	33
SwissProt Accessions	Q13136, Q13135, Q14567, Q8N4I2	Gene names	PPFIA1, LIP1
Domain Architecture
Description	Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) (LAR-interacting protein 1) (LIP.1).

MAST3_HUMAN
θ value	0.62314 (rank : 82)	NC score	0.138644 (rank : 69)
Query Neighborhood Hits	185	Target Neighborhood Hits	1128	Shared Neighborhood Hits	83
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

PZRN3_HUMAN
θ value	0.62314 (rank : 83)	NC score	0.111972 (rank : 154)
Query Neighborhood Hits	185	Target Neighborhood Hits	461	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

SDCB2_HUMAN
θ value	0.62314 (rank : 84)	NC score	0.138275 (rank : 71)
Query Neighborhood Hits	185	Target Neighborhood Hits	121	Shared Neighborhood Hits	35
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

STAC3_MOUSE
θ value	0.62314 (rank : 85)	NC score	0.230589 (rank : 15)
Query Neighborhood Hits	185	Target Neighborhood Hits	232	Shared Neighborhood Hits	57
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ADA2A_MOUSE
θ value	0.813845 (rank : 86)	NC score	0.003762 (rank : 960)
Query Neighborhood Hits	185	Target Neighborhood Hits	900	Shared Neighborhood Hits	3
SwissProt Accessions	Q01338	Gene names	Adra2a
Domain Architecture
Description	Alpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2A adrenoreceptor) (Alpha-2AAR).

CF152_MOUSE
θ value	0.813845 (rank : 87)	NC score	0.055188 (rank : 835)
Query Neighborhood Hits	185	Target Neighborhood Hits	597	Shared Neighborhood Hits	25
SwissProt Accessions	Q80ST9, Q9CYM9, Q9D5J9	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf152 homolog.

LR37A_HUMAN
θ value	0.813845 (rank : 88)	NC score	0.035742 (rank : 912)
Query Neighborhood Hits	185	Target Neighborhood Hits	720	Shared Neighborhood Hits	27
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

MAST1_MOUSE
θ value	0.813845 (rank : 89)	NC score	0.140318 (rank : 66)
Query Neighborhood Hits	185	Target Neighborhood Hits	1123	Shared Neighborhood Hits	76
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST2_HUMAN
θ value	0.813845 (rank : 90)	NC score	0.139192 (rank : 68)
Query Neighborhood Hits	185	Target Neighborhood Hits	1189	Shared Neighborhood Hits	83
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MRCKB_HUMAN
θ value	0.813845 (rank : 91)	NC score	0.128833 (rank : 80)
Query Neighborhood Hits	185	Target Neighborhood Hits	2239	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

NCOA6_MOUSE
θ value	0.813845 (rank : 92)	NC score	0.050338 (rank : 898)
Query Neighborhood Hits	185	Target Neighborhood Hits	1076	Shared Neighborhood Hits	33
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

PDZK4_HUMAN
θ value	1.06291 (rank : 93)	NC score	0.095793 (rank : 226)
Query Neighborhood Hits	185	Target Neighborhood Hits	165	Shared Neighborhood Hits	36
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

WHRN_HUMAN
θ value	1.06291 (rank : 94)	NC score	0.140675 (rank : 65)
Query Neighborhood Hits	185	Target Neighborhood Hits	325	Shared Neighborhood Hits	48
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

CS007_MOUSE
θ value	1.38821 (rank : 95)	NC score	0.041471 (rank : 908)
Query Neighborhood Hits	185	Target Neighborhood Hits	464	Shared Neighborhood Hits	14
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

EP15R_MOUSE
θ value	1.38821 (rank : 96)	NC score	0.029628 (rank : 923)
Query Neighborhood Hits	185	Target Neighborhood Hits	1135	Shared Neighborhood Hits	35
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

HERC2_MOUSE
θ value	1.38821 (rank : 97)	NC score	0.024418 (rank : 934)
Query Neighborhood Hits	185	Target Neighborhood Hits	167	Shared Neighborhood Hits	6
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

SDCB2_MOUSE
θ value	1.38821 (rank : 98)	NC score	0.126655 (rank : 85)
Query Neighborhood Hits	185	Target Neighborhood Hits	118	Shared Neighborhood Hits	32
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

TMEPA_MOUSE
θ value	1.38821 (rank : 99)	NC score	0.067011 (rank : 636)
Query Neighborhood Hits	185	Target Neighborhood Hits	46	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D7R2, Q9EQH9	Gene names	Tmepai, N4wbp4
Domain Architecture	No domain graphic available
Description	Transmembrane prostate androgen-induced protein (NEDD4 WW domain- binding protein 4).

TPR_HUMAN
θ value	1.38821 (rank : 100)	NC score	0.025768 (rank : 931)
Query Neighborhood Hits	185	Target Neighborhood Hits	1921	Shared Neighborhood Hits	40
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

GRIP1_HUMAN
θ value	1.81305 (rank : 101)	NC score	0.110493 (rank : 161)
Query Neighborhood Hits	185	Target Neighborhood Hits	231	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

GRIP1_MOUSE
θ value	1.81305 (rank : 102)	NC score	0.111114 (rank : 158)
Query Neighborhood Hits	185	Target Neighborhood Hits	241	Shared Neighborhood Hits	47
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

HRX_HUMAN
θ value	1.81305 (rank : 103)	NC score	0.038579 (rank : 911)
Query Neighborhood Hits	185	Target Neighborhood Hits	825	Shared Neighborhood Hits	33
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

LTB1L_MOUSE
θ value	1.81305 (rank : 104)	NC score	0.013136 (rank : 955)
Query Neighborhood Hits	185	Target Neighborhood Hits	514	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CG19, O88349, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTB1S_MOUSE
θ value	1.81305 (rank : 105)	NC score	0.012965 (rank : 956)
Query Neighborhood Hits	185	Target Neighborhood Hits	479	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CG18, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

NCOA6_HUMAN
θ value	1.81305 (rank : 106)	NC score	0.049452 (rank : 904)
Query Neighborhood Hits	185	Target Neighborhood Hits	1202	Shared Neighborhood Hits	39
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

PARD3_MOUSE
θ value	1.81305 (rank : 107)	NC score	0.119653 (rank : 103)
Query Neighborhood Hits	185	Target Neighborhood Hits	290	Shared Neighborhood Hits	44
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

VAV_MOUSE
θ value	1.81305 (rank : 108)	NC score	0.110169 (rank : 163)
Query Neighborhood Hits	185	Target Neighborhood Hits	430	Shared Neighborhood Hits	54
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ZO1_HUMAN
θ value	1.81305 (rank : 109)	NC score	0.117505 (rank : 119)
Query Neighborhood Hits	185	Target Neighborhood Hits	474	Shared Neighborhood Hits	58
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZO1_MOUSE
θ value	1.81305 (rank : 110)	NC score	0.117052 (rank : 124)
Query Neighborhood Hits	185	Target Neighborhood Hits	453	Shared Neighborhood Hits	57
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

CR001_HUMAN
θ value	2.36792 (rank : 111)	NC score	0.057634 (rank : 802)
Query Neighborhood Hits	185	Target Neighborhood Hits	68	Shared Neighborhood Hits	5
SwissProt Accessions	O15165, O15166, O15167, O15168, Q6NXP3	Gene names	C18orf1
Domain Architecture
Description	Protein C18orf1.

CR001_MOUSE
θ value	2.36792 (rank : 112)	NC score	0.057515 (rank : 804)
Query Neighborhood Hits	185	Target Neighborhood Hits	67	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BWJ4	Gene names	D18Ertd653e
Domain Architecture	No domain graphic available
Description	Protein C18orf1 homolog.

DPOG1_HUMAN
θ value	2.36792 (rank : 113)	NC score	0.041157 (rank : 909)
Query Neighborhood Hits	185	Target Neighborhood Hits	28	Shared Neighborhood Hits	4
SwissProt Accessions	P54098, Q8NFM2, Q92515	Gene names	POLG, MDP1, POLG1, POLGA
Domain Architecture
Description	DNA polymerase subunit gamma 1 (EC 2.7.7.7) (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha).

GLIS1_HUMAN
θ value	2.36792 (rank : 114)	NC score	0.000951 (rank : 963)
Query Neighborhood Hits	185	Target Neighborhood Hits	748	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NBF1, Q8N9V9	Gene names	GLIS1
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS1 (GLI-similar 1).

MUC5B_HUMAN
θ value	2.36792 (rank : 115)	NC score	0.018739 (rank : 948)
Query Neighborhood Hits	185	Target Neighborhood Hits	1020	Shared Neighborhood Hits	17
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

NHERF_HUMAN
θ value	2.36792 (rank : 116)	NC score	0.172221 (rank : 40)
Query Neighborhood Hits	185	Target Neighborhood Hits	190	Shared Neighborhood Hits	45
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

RGNEF_MOUSE
θ value	2.36792 (rank : 117)	NC score	0.108118 (rank : 177)
Query Neighborhood Hits	185	Target Neighborhood Hits	641	Shared Neighborhood Hits	72
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

SDC3_MOUSE
θ value	2.36792 (rank : 118)	NC score	0.039724 (rank : 910)
Query Neighborhood Hits	185	Target Neighborhood Hits	107	Shared Neighborhood Hits	7
SwissProt Accessions	Q64519, Q3UDD9, Q6ZQA4, Q7TQD4	Gene names	Sdc3, Kiaa0468
Domain Architecture
Description	Syndecan-3 precursor (SYND3).

VAV_HUMAN
θ value	2.36792 (rank : 119)	NC score	0.112362 (rank : 149)
Query Neighborhood Hits	185	Target Neighborhood Hits	452	Shared Neighborhood Hits	57
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ZO3_MOUSE
θ value	2.36792 (rank : 120)	NC score	0.124650 (rank : 87)
Query Neighborhood Hits	185	Target Neighborhood Hits	224	Shared Neighborhood Hits	46
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

ACINU_MOUSE
θ value	3.0926 (rank : 121)	NC score	0.048933 (rank : 905)
Query Neighborhood Hits	185	Target Neighborhood Hits	712	Shared Neighborhood Hits	37
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

BRAF1_HUMAN
θ value	3.0926 (rank : 122)	NC score	0.079502 (rank : 403)
Query Neighborhood Hits	185	Target Neighborhood Hits	883	Shared Neighborhood Hits	64
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

DGKA_MOUSE
θ value	3.0926 (rank : 123)	NC score	0.118866 (rank : 106)
Query Neighborhood Hits	185	Target Neighborhood Hits	146	Shared Neighborhood Hits	37
SwissProt Accessions	O88673, Q922X2	Gene names	Dgka, Dagk1
Domain Architecture
Description	Diacylglycerol kinase alpha (EC 2.7.1.107) (Diglyceride kinase alpha) (DGK-alpha) (DAG kinase alpha) (80 kDa diacylglycerol kinase).

FA5_HUMAN
θ value	3.0926 (rank : 124)	NC score	0.016025 (rank : 951)
Query Neighborhood Hits	185	Target Neighborhood Hits	172	Shared Neighborhood Hits	4
SwissProt Accessions	P12259, Q14285, Q6UPU6	Gene names	F5
Domain Architecture
Description	Coagulation factor V precursor (Activated protein C cofactor) [Contains: Coagulation factor V heavy chain; Coagulation factor V light chain].

GAK4_HUMAN
θ value	3.0926 (rank : 125)	NC score	0.021978 (rank : 938)
Query Neighborhood Hits	185	Target Neighborhood Hits	415	Shared Neighborhood Hits	16
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

HIP1R_HUMAN
θ value	3.0926 (rank : 126)	NC score	0.033582 (rank : 915)
Query Neighborhood Hits	185	Target Neighborhood Hits	809	Shared Neighborhood Hits	28
SwissProt Accessions	O75146, Q9UED9	Gene names	HIP1R, HIP12, KIAA0655
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related) (Hip 12).

MYNN_HUMAN
θ value	3.0926 (rank : 127)	NC score	-0.002377 (rank : 964)
Query Neighborhood Hits	185	Target Neighborhood Hits	826	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NPC7, Q6QHA6, Q6QHA7, Q6R3G1, Q6R3G2, Q6R4A0, Q7Z716, Q7Z717, Q86Z11, Q86Z12, Q9NS01, Q9UIW8	Gene names	MYNN, OSZF, ZBTB31
Domain Architecture	No domain graphic available
Description	Myoneurin (Zinc finger and BTB domain-containing protein 31).

PDZD3_MOUSE
θ value	3.0926 (rank : 128)	NC score	0.172418 (rank : 39)
Query Neighborhood Hits	185	Target Neighborhood Hits	171	Shared Neighborhood Hits	42
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

TBC10_MOUSE
θ value	3.0926 (rank : 129)	NC score	0.021078 (rank : 939)
Query Neighborhood Hits	185	Target Neighborhood Hits	94	Shared Neighborhood Hits	4
SwissProt Accessions	P58802	Gene names	Tbc1d10a, Epi64, Tbc1d10
Domain Architecture
Description	TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein).

TMEPA_HUMAN
θ value	3.0926 (rank : 130)	NC score	0.060684 (rank : 741)
Query Neighborhood Hits	185	Target Neighborhood Hits	46	Shared Neighborhood Hits	5
SwissProt Accessions	Q969W9, Q5TDR6, Q96B72, Q9UJD3	Gene names	TMEPAI, PMEPA1, STAG1
Domain Architecture
Description	Transmembrane prostate androgen-induced protein (Solid tumor- associated 1 protein).

ARHG2_HUMAN
θ value	4.03905 (rank : 131)	NC score	0.100709 (rank : 212)
Query Neighborhood Hits	185	Target Neighborhood Hits	142	Shared Neighborhood Hits	33
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	4.03905 (rank : 132)	NC score	0.096417 (rank : 223)
Query Neighborhood Hits	185	Target Neighborhood Hits	120	Shared Neighborhood Hits	33
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

CEP63_HUMAN
θ value	4.03905 (rank : 133)	NC score	0.025482 (rank : 932)
Query Neighborhood Hits	185	Target Neighborhood Hits	1005	Shared Neighborhood Hits	28
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

DAB1_HUMAN
θ value	4.03905 (rank : 134)	NC score	0.023998 (rank : 935)
Query Neighborhood Hits	185	Target Neighborhood Hits	219	Shared Neighborhood Hits	10
SwissProt Accessions	O75553, Q9NYA8	Gene names	DAB1
Domain Architecture
Description	Disabled homolog 1.

GA2L2_HUMAN
θ value	4.03905 (rank : 135)	NC score	0.027771 (rank : 928)
Query Neighborhood Hits	185	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NHY3, Q8NHY4	Gene names	GAS2L2, GAR17
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2) (GAS2-related protein on chromosome 17) (GAR17 protein).

PARD3_HUMAN
θ value	4.03905 (rank : 136)	NC score	0.117593 (rank : 116)
Query Neighborhood Hits	185	Target Neighborhood Hits	312	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

PKCB1_HUMAN
θ value	4.03905 (rank : 137)	NC score	0.033955 (rank : 914)
Query Neighborhood Hits	185	Target Neighborhood Hits	488	Shared Neighborhood Hits	22
SwissProt Accessions	Q9ULU4, Q13517, Q4JJ94, Q4JJ95, Q5TH09, Q6MZM1, Q8WXC5, Q9H1F3, Q9H1F4, Q9H1F5, Q9H1L8, Q9H1L9, Q9H2G5, Q9NYN3, Q9UIX6	Gene names	PRKCBP1, KIAA1125, RACK7, ZMYND8
Domain Architecture
Description	Protein kinase C-binding protein 1 (Rack7) (Cutaneous T-cell lymphoma- associated antigen se14-3) (CTCL tumor antigen se14-3) (Zinc finger MYND domain-containing protein 8).

ROCK1_HUMAN
θ value	4.03905 (rank : 138)	NC score	0.114541 (rank : 131)
Query Neighborhood Hits	185	Target Neighborhood Hits	2000	Shared Neighborhood Hits	71
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

TRI62_HUMAN
θ value	4.03905 (rank : 139)	NC score	0.010801 (rank : 957)
Query Neighborhood Hits	185	Target Neighborhood Hits	584	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BVG3, Q9NVG0	Gene names	TRIM62
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 62.

CENPF_HUMAN
θ value	5.27518 (rank : 140)	NC score	0.022494 (rank : 937)
Query Neighborhood Hits	185	Target Neighborhood Hits	1932	Shared Neighborhood Hits	37
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

CKAP4_MOUSE
θ value	5.27518 (rank : 141)	NC score	0.032897 (rank : 918)
Query Neighborhood Hits	185	Target Neighborhood Hits	596	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BMK4, Q8BTK8, Q8R3F2	Gene names	Ckap4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

CT2NL_HUMAN
θ value	5.27518 (rank : 142)	NC score	0.023837 (rank : 936)
Query Neighborhood Hits	185	Target Neighborhood Hits	1059	Shared Neighborhood Hits	30
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

CTRO_HUMAN
θ value	5.27518 (rank : 143)	NC score	0.109502 (rank : 167)
Query Neighborhood Hits	185	Target Neighborhood Hits	2092	Shared Neighborhood Hits	71
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

CTRO_MOUSE
θ value	5.27518 (rank : 144)	NC score	0.105447 (rank : 185)
Query Neighborhood Hits	185	Target Neighborhood Hits	2344	Shared Neighborhood Hits	73
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

ECM1_HUMAN
θ value	5.27518 (rank : 145)	NC score	0.033350 (rank : 916)
Query Neighborhood Hits	185	Target Neighborhood Hits	182	Shared Neighborhood Hits	12
SwissProt Accessions	Q16610	Gene names	ECM1
Domain Architecture
Description	Extracellular matrix protein 1 precursor (Secretory component p85).

HIP1R_MOUSE
θ value	5.27518 (rank : 146)	NC score	0.032313 (rank : 920)
Query Neighborhood Hits	185	Target Neighborhood Hits	959	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JKY5	Gene names	Hip1r
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related).

LBXCO_HUMAN
θ value	5.27518 (rank : 147)	NC score	0.031128 (rank : 921)
Query Neighborhood Hits	185	Target Neighborhood Hits	167	Shared Neighborhood Hits	11
SwissProt Accessions	P84550	Gene names	LBXCOR1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1.

LBXCO_MOUSE
θ value	5.27518 (rank : 148)	NC score	0.030118 (rank : 922)
Query Neighborhood Hits	185	Target Neighborhood Hits	140	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BX46, Q3UYA4, Q5W8I2, Q8C0T2	Gene names	Lbxcor1, Corl1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1 (Transcriptional corepressor Corl1).

LIPA2_HUMAN
θ value	5.27518 (rank : 149)	NC score	0.029627 (rank : 924)
Query Neighborhood Hits	185	Target Neighborhood Hits	1044	Shared Neighborhood Hits	29
SwissProt Accessions	O75334	Gene names	PPFIA2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

PICK1_HUMAN
θ value	5.27518 (rank : 150)	NC score	0.068119 (rank : 615)
Query Neighborhood Hits	185	Target Neighborhood Hits	132	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PICK1_MOUSE
θ value	5.27518 (rank : 151)	NC score	0.067990 (rank : 617)
Query Neighborhood Hits	185	Target Neighborhood Hits	131	Shared Neighborhood Hits	32
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

YO11_MOUSE
θ value	5.27518 (rank : 152)	NC score	0.033276 (rank : 917)
Query Neighborhood Hits	185	Target Neighborhood Hits	272	Shared Neighborhood Hits	14
SwissProt Accessions	P11260	Gene names
Domain Architecture
Description	Hypothetical protein ORF-1137.

ZBT16_HUMAN
θ value	5.27518 (rank : 153)	NC score	-0.002806 (rank : 965)
Query Neighborhood Hits	185	Target Neighborhood Hits	1010	Shared Neighborhood Hits	7
SwissProt Accessions	Q05516, Q8TAL4	Gene names	ZBTB16, PLZF, ZNF145
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 16 (Zinc finger protein PLZF) (Promyelocytic leukemia zinc finger protein) (Zinc finger protein 145).

ZO2_HUMAN
θ value	5.27518 (rank : 154)	NC score	0.115446 (rank : 129)
Query Neighborhood Hits	185	Target Neighborhood Hits	289	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ARAF_MOUSE
θ value	6.88961 (rank : 155)	NC score	0.078193 (rank : 423)
Query Neighborhood Hits	185	Target Neighborhood Hits	874	Shared Neighborhood Hits	63
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

CCHCR_MOUSE
θ value	6.88961 (rank : 156)	NC score	0.024783 (rank : 933)
Query Neighborhood Hits	185	Target Neighborhood Hits	932	Shared Neighborhood Hits	30
SwissProt Accessions	Q8K2I2	Gene names	Cchcr1, Hcr
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein).

DDX11_HUMAN
θ value	6.88961 (rank : 157)	NC score	0.018869 (rank : 947)
Query Neighborhood Hits	185	Target Neighborhood Hits	124	Shared Neighborhood Hits	10
SwissProt Accessions	Q96FC9, Q13333, Q86VQ4, Q86W62, Q92498, Q92770, Q92998, Q92999	Gene names	DDX11, CHL1, CHLR1, KRG2
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX11 (EC 3.6.1.-) (DEAD/H box protein 11) (CHL1 homolog) (Keratinocyte growth factor-regulated gene 2 protein) (KRG-2).

DGKB_HUMAN
θ value	6.88961 (rank : 158)	NC score	0.192945 (rank : 22)
Query Neighborhood Hits	185	Target Neighborhood Hits	238	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y6T7, O75241, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29	Gene names	DGKB, DAGK2, KIAA0718
Domain Architecture
Description	Diacylglycerol kinase beta (EC 2.7.1.107) (Diglyceride kinase beta) (DGK-beta) (DAG kinase beta) (90 kDa diacylglycerol kinase).

DPOG1_MOUSE
θ value	6.88961 (rank : 159)	NC score	0.035037 (rank : 913)
Query Neighborhood Hits	185	Target Neighborhood Hits	26	Shared Neighborhood Hits	5
SwissProt Accessions	P54099, Q9JI28	Gene names	Polg, Polg1
Domain Architecture
Description	DNA polymerase subunit gamma 1 (EC 2.7.7.7) (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha).

GAK11_HUMAN
θ value	6.88961 (rank : 160)	NC score	0.019814 (rank : 941)
Query Neighborhood Hits	185	Target Neighborhood Hits	409	Shared Neighborhood Hits	16
SwissProt Accessions	P63145, Q9UKI1	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_22q11.21 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K101 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK2_HUMAN
θ value	6.88961 (rank : 161)	NC score	0.019475 (rank : 943)
Query Neighborhood Hits	185	Target Neighborhood Hits	406	Shared Neighborhood Hits	17
SwissProt Accessions	Q7LDI9, Q9UKH5, Q9Y6I1, Q9YNA6, Q9YNB0	Gene names	ERVK6
Domain Architecture	No domain graphic available
Description	HERV-K_7p22.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K(C7) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

HERC2_HUMAN
θ value	6.88961 (rank : 162)	NC score	0.019443 (rank : 944)
Query Neighborhood Hits	185	Target Neighborhood Hits	163	Shared Neighborhood Hits	4
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

K1802_HUMAN
θ value	6.88961 (rank : 163)	NC score	0.019737 (rank : 942)
Query Neighborhood Hits	185	Target Neighborhood Hits	1378	Shared Neighborhood Hits	37
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MYH10_MOUSE
θ value	6.88961 (rank : 164)	NC score	0.026880 (rank : 929)
Query Neighborhood Hits	185	Target Neighborhood Hits	1612	Shared Neighborhood Hits	35
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

RGAP1_HUMAN
θ value	6.88961 (rank : 165)	NC score	0.105914 (rank : 183)
Query Neighborhood Hits	185	Target Neighborhood Hits	189	Shared Neighborhood Hits	45
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RGAP1_MOUSE
θ value	6.88961 (rank : 166)	NC score	0.110267 (rank : 162)
Query Neighborhood Hits	185	Target Neighborhood Hits	185	Shared Neighborhood Hits	42
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

SC24C_HUMAN
θ value	6.88961 (rank : 167)	NC score	0.020192 (rank : 940)
Query Neighborhood Hits	185	Target Neighborhood Hits	662	Shared Neighborhood Hits	19
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

SETB1_MOUSE
θ value	6.88961 (rank : 168)	NC score	0.018709 (rank : 949)
Query Neighborhood Hits	185	Target Neighborhood Hits	150	Shared Neighborhood Hits	14
SwissProt Accessions	O88974, Q922K1	Gene names	Setdb1, Eset
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (SET domain bifurcated 1) (ERG-associated protein with SET domain) (ESET).

STAB2_MOUSE
θ value	6.88961 (rank : 169)	NC score	0.007297 (rank : 959)
Query Neighborhood Hits	185	Target Neighborhood Hits	528	Shared Neighborhood Hits	10
SwissProt Accessions	Q8R4U0, Q8BM87	Gene names	Stab2
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor [Contains: Short form stabilin-2].

USP9X_HUMAN
θ value	6.88961 (rank : 170)	NC score	0.013889 (rank : 954)
Query Neighborhood Hits	185	Target Neighborhood Hits	161	Shared Neighborhood Hits	6
SwissProt Accessions	Q93008, O75550, Q8WWT3, Q8WX12	Gene names	USP9X, DFFRX, USP9
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein-related, X- linked) (Ubiquitin-specific protease 9, X chromosome).

USP9X_MOUSE
θ value	6.88961 (rank : 171)	NC score	0.014037 (rank : 953)
Query Neighborhood Hits	185	Target Neighborhood Hits	171	Shared Neighborhood Hits	4
SwissProt Accessions	P70398, Q62497	Gene names	Usp9x, Fafl, Fam
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein-related, X- linked) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin carboxyl-terminal hydrolase FAM) (Fat facets homolog).

ARAF_HUMAN
θ value	8.99809 (rank : 172)	NC score	0.075931 (rank : 459)
Query Neighborhood Hits	185	Target Neighborhood Hits	924	Shared Neighborhood Hits	62
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

C1RA_MOUSE
θ value	8.99809 (rank : 173)	NC score	0.002918 (rank : 961)
Query Neighborhood Hits	185	Target Neighborhood Hits	379	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CG16, Q99KI6, Q9ET60	Gene names	C1ra, C1r
Domain Architecture
Description	Complement C1r-A subcomponent precursor (EC 3.4.21.41) (Complement component 1, r-A subcomponent) [Contains: Complement C1r-A subcomponent heavy chain; Complement C1r-A subcomponent light chain].

C1RB_MOUSE
θ value	8.99809 (rank : 174)	NC score	0.002811 (rank : 962)
Query Neighborhood Hits	185	Target Neighborhood Hits	380	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CFG9	Gene names	C1rb, C1r
Domain Architecture	No domain graphic available
Description	Complement C1r-B subcomponent precursor (EC 3.4.21.41) (Complement component 1, r-B subcomponent) [Contains: Complement C1r-B subcomponent heavy chain; Complement C1r-B subcomponent light chain].

ESAM_HUMAN
θ value	8.99809 (rank : 175)	NC score	0.008903 (rank : 958)
Query Neighborhood Hits	185	Target Neighborhood Hits	251	Shared Neighborhood Hits	3
SwissProt Accessions	Q96AP7, Q96T50	Gene names	ESAM
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

FA61B_MOUSE
θ value	8.99809 (rank : 176)	NC score	0.014496 (rank : 952)
Query Neighborhood Hits	185	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CGC4	Gene names	Fam61b
Domain Architecture	No domain graphic available
Description	Protein FAM61B.

GA2L2_MOUSE
θ value	8.99809 (rank : 177)	NC score	0.019367 (rank : 945)
Query Neighborhood Hits	185	Target Neighborhood Hits	395	Shared Neighborhood Hits	11
SwissProt Accessions	Q5SSG4	Gene names	Gas2l2
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2).

GAK5_HUMAN
θ value	8.99809 (rank : 178)	NC score	0.018918 (rank : 946)
Query Neighborhood Hits	185	Target Neighborhood Hits	429	Shared Neighborhood Hits	16
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GMIP_HUMAN
θ value	8.99809 (rank : 179)	NC score	0.098804 (rank : 219)
Query Neighborhood Hits	185	Target Neighborhood Hits	225	Shared Neighborhood Hits	41
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

MKL1_MOUSE
θ value	8.99809 (rank : 180)	NC score	0.017513 (rank : 950)
Query Neighborhood Hits	185	Target Neighborhood Hits	667	Shared Neighborhood Hits	20
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

MYH10_HUMAN
θ value	8.99809 (rank : 181)	NC score	0.026680 (rank : 930)
Query Neighborhood Hits	185	Target Neighborhood Hits	1620	Shared Neighborhood Hits	35
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

NHERF_MOUSE
θ value	8.99809 (rank : 182)	NC score	0.167553 (rank : 45)
Query Neighborhood Hits	185	Target Neighborhood Hits	195	Shared Neighborhood Hits	44
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

OSTP_HUMAN
θ value	8.99809 (rank : 183)	NC score	0.028207 (rank : 927)
Query Neighborhood Hits	185	Target Neighborhood Hits	36	Shared Neighborhood Hits	5
SwissProt Accessions	P10451, Q15681, Q15682, Q15683, Q8NBK2, Q96IZ1	Gene names	SPP1, OPN
Domain Architecture
Description	Osteopontin precursor (Bone sialoprotein-1) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Nephropontin) (Uropontin).

RGS3_HUMAN
θ value	8.99809 (rank : 184)	NC score	0.079941 (rank : 399)
Query Neighborhood Hits	185	Target Neighborhood Hits	1375	Shared Neighborhood Hits	64
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

TXLNB_HUMAN
θ value	8.99809 (rank : 185)	NC score	0.029332 (rank : 925)
Query Neighborhood Hits	185	Target Neighborhood Hits	912	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

3BP1_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.068154 (rank : 614)
Query Neighborhood Hits	185	Target Neighborhood Hits	376	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

3BP1_MOUSE
θ value	θ > 10 (rank : 187)	NC score	0.061305 (rank : 722)
Query Neighborhood Hits	185	Target Neighborhood Hits	238	Shared Neighborhood Hits	20
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

AAK1_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.062073 (rank : 713)
Query Neighborhood Hits	185	Target Neighborhood Hits	1077	Shared Neighborhood Hits	59
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

AAK1_MOUSE
θ value	θ > 10 (rank : 189)	NC score	0.058548 (rank : 781)
Query Neighborhood Hits	185	Target Neighborhood Hits	1051	Shared Neighborhood Hits	51
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

AAPK1_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.088228 (rank : 288)
Query Neighborhood Hits	185	Target Neighborhood Hits	842	Shared Neighborhood Hits	40
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK1_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.088699 (rank : 278)
Query Neighborhood Hits	185	Target Neighborhood Hits	843	Shared Neighborhood Hits	40
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK2_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.088895 (rank : 273)
Query Neighborhood Hits	185	Target Neighborhood Hits	843	Shared Neighborhood Hits	40
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

AATK_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.053094 (rank : 852)
Query Neighborhood Hits	185	Target Neighborhood Hits	1243	Shared Neighborhood Hits	53
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

AATK_MOUSE
θ value	θ > 10 (rank : 194)	NC score	0.055113 (rank : 836)
Query Neighborhood Hits	185	Target Neighborhood Hits	942	Shared Neighborhood Hits	49
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ABL1_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.060939 (rank : 732)
Query Neighborhood Hits	185	Target Neighborhood Hits	1220	Shared Neighborhood Hits	54
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	θ > 10 (rank : 196)	NC score	0.062644 (rank : 702)
Query Neighborhood Hits	185	Target Neighborhood Hits	1178	Shared Neighborhood Hits	62
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.060873 (rank : 737)
Query Neighborhood Hits	185	Target Neighborhood Hits	1045	Shared Neighborhood Hits	52
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ABR_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.059726 (rank : 761)
Query Neighborhood Hits	185	Target Neighborhood Hits	166	Shared Neighborhood Hits	20
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ACK1_MOUSE
θ value	θ > 10 (rank : 199)	NC score	0.053585 (rank : 850)
Query Neighborhood Hits	185	Target Neighborhood Hits	1080	Shared Neighborhood Hits	57
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

AFAD_HUMAN
θ value	θ > 10 (rank : 200)	NC score	0.081463 (rank : 393)
Query Neighborhood Hits	185	Target Neighborhood Hits	689	Shared Neighborhood Hits	69
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

AKT1_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.119642 (rank : 104)
Query Neighborhood Hits	185	Target Neighborhood Hits	885	Shared Neighborhood Hits	41
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

AKT1_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.119754 (rank : 102)
Query Neighborhood Hits	185	Target Neighborhood Hits	878	Shared Neighborhood Hits	40
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

AKT2_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.117990 (rank : 111)
Query Neighborhood Hits	185	Target Neighborhood Hits	878	Shared Neighborhood Hits	40
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT2_MOUSE
θ value	θ > 10 (rank : 204)	NC score	0.118006 (rank : 110)
Query Neighborhood Hits	185	Target Neighborhood Hits	875	Shared Neighborhood Hits	40
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT3_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.117865 (rank : 113)
Query Neighborhood Hits	185	Target Neighborhood Hits	872	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
θ value	θ > 10 (rank : 206)	NC score	0.117884 (rank : 112)
Query Neighborhood Hits	185	Target Neighborhood Hits	872	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

AL2S2_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.055397 (rank : 833)
Query Neighborhood Hits	185	Target Neighborhood Hits	727	Shared Neighborhood Hits	40
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

AL2S2_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.055036 (rank : 837)
Query Neighborhood Hits	185	Target Neighborhood Hits	709	Shared Neighborhood Hits	40
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

AL2S7_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.068872 (rank : 599)
Query Neighborhood Hits	185	Target Neighborhood Hits	831	Shared Neighborhood Hits	40
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

ANKK1_MOUSE
θ value	θ > 10 (rank : 210)	NC score	0.050651 (rank : 893)
Query Neighborhood Hits	185	Target Neighborhood Hits	1072	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

APBA1_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.068435 (rank : 609)
Query Neighborhood Hits	185	Target Neighborhood Hits	325	Shared Neighborhood Hits	46
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

APBA2_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.067577 (rank : 628)
Query Neighborhood Hits	185	Target Neighborhood Hits	220	Shared Neighborhood Hits	41
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.067685 (rank : 624)
Query Neighborhood Hits	185	Target Neighborhood Hits	219	Shared Neighborhood Hits	42
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA3_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.064775 (rank : 675)
Query Neighborhood Hits	185	Target Neighborhood Hits	201	Shared Neighborhood Hits	46
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

APBA3_MOUSE
θ value	θ > 10 (rank : 215)	NC score	0.054881 (rank : 839)
Query Neighborhood Hits	185	Target Neighborhood Hits	174	Shared Neighborhood Hits	41
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

ARBK1_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.114123 (rank : 133)
Query Neighborhood Hits	185	Target Neighborhood Hits	859	Shared Neighborhood Hits	43
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

ARBK1_MOUSE
θ value	θ > 10 (rank : 217)	NC score	0.113657 (rank : 135)
Query Neighborhood Hits	185	Target Neighborhood Hits	849	Shared Neighborhood Hits	41
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

ARBK2_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.113485 (rank : 137)
Query Neighborhood Hits	185	Target Neighborhood Hits	849	Shared Neighborhood Hits	40
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

ARHG1_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.050230 (rank : 899)
Query Neighborhood Hits	185	Target Neighborhood Hits	176	Shared Neighborhood Hits	10
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.050447 (rank : 897)
Query Neighborhood Hits	185	Target Neighborhood Hits	266	Shared Neighborhood Hits	12
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

AURKB_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.090295 (rank : 255)
Query Neighborhood Hits	185	Target Neighborhood Hits	847	Shared Neighborhood Hits	40
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

AURKB_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.091029 (rank : 247)
Query Neighborhood Hits	185	Target Neighborhood Hits	858	Shared Neighborhood Hits	40
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

AURKC_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.090742 (rank : 249)
Query Neighborhood Hits	185	Target Neighborhood Hits	847	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

AURKC_MOUSE
θ value	θ > 10 (rank : 224)	NC score	0.089671 (rank : 260)
Query Neighborhood Hits	185	Target Neighborhood Hits	844	Shared Neighborhood Hits	40
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

BAIP3_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.065320 (rank : 664)
Query Neighborhood Hits	185	Target Neighborhood Hits	108	Shared Neighborhood Hits	11
SwissProt Accessions	O94812, O94839, Q2M226, Q658J2, Q76N05, Q96RZ3, Q9UJK1	Gene names	BAIAP3, KIAA0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

BAIP3_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.058332 (rank : 789)
Query Neighborhood Hits	185	Target Neighborhood Hits	112	Shared Neighborhood Hits	10
SwissProt Accessions	Q80TT2, Q6RUT4	Gene names	Baiap3, Gm937, Kiaa0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

BCR_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.058461 (rank : 784)
Query Neighborhood Hits	185	Target Neighborhood Hits	204	Shared Neighborhood Hits	21
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

BLK_HUMAN
θ value	θ > 10 (rank : 228)	NC score	0.051239 (rank : 879)
Query Neighborhood Hits	185	Target Neighborhood Hits	994	Shared Neighborhood Hits	48
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BMP2K_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.061289 (rank : 723)
Query Neighborhood Hits	185	Target Neighborhood Hits	867	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

BMP2K_MOUSE
θ value	θ > 10 (rank : 230)	NC score	0.062941 (rank : 698)
Query Neighborhood Hits	185	Target Neighborhood Hits	874	Shared Neighborhood Hits	44
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

BMX_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.058334 (rank : 788)
Query Neighborhood Hits	185	Target Neighborhood Hits	942	Shared Neighborhood Hits	41
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
θ value	θ > 10 (rank : 232)	NC score	0.058390 (rank : 786)
Query Neighborhood Hits	185	Target Neighborhood Hits	912	Shared Neighborhood Hits	41
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BRSK1_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.086425 (rank : 309)
Query Neighborhood Hits	185	Target Neighborhood Hits	942	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

BRSK2_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.085170 (rank : 332)
Query Neighborhood Hits	185	Target Neighborhood Hits	897	Shared Neighborhood Hits	42
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

BTK_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.060891 (rank : 736)
Query Neighborhood Hits	185	Target Neighborhood Hits	1026	Shared Neighborhood Hits	47
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
θ value	θ > 10 (rank : 236)	NC score	0.060154 (rank : 751)
Query Neighborhood Hits	185	Target Neighborhood Hits	1017	Shared Neighborhood Hits	46
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

BUB1_MOUSE
θ value	θ > 10 (rank : 237)	NC score	0.050804 (rank : 892)
Query Neighborhood Hits	185	Target Neighborhood Hits	583	Shared Neighborhood Hits	38
SwissProt Accessions	O08901, O09007	Gene names	Bub1
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (MBUB1) (BUB1A).

CAMKV_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.085339 (rank : 329)
Query Neighborhood Hits	185	Target Neighborhood Hits	1084	Shared Neighborhood Hits	44
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CAMKV_MOUSE
θ value	θ > 10 (rank : 239)	NC score	0.086350 (rank : 312)
Query Neighborhood Hits	185	Target Neighborhood Hits	848	Shared Neighborhood Hits	44
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CCRK_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.065738 (rank : 653)
Query Neighborhood Hits	185	Target Neighborhood Hits	835	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

CCRK_MOUSE
θ value	θ > 10 (rank : 241)	NC score	0.066328 (rank : 644)
Query Neighborhood Hits	185	Target Neighborhood Hits	832	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

CD2L1_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.070155 (rank : 578)
Query Neighborhood Hits	185	Target Neighborhood Hits	1467	Shared Neighborhood Hits	61
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

CD2L1_MOUSE
θ value	θ > 10 (rank : 243)	NC score	0.070452 (rank : 572)
Query Neighborhood Hits	185	Target Neighborhood Hits	1463	Shared Neighborhood Hits	59
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

CD2L2_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.070322 (rank : 573)
Query Neighborhood Hits	185	Target Neighborhood Hits	1439	Shared Neighborhood Hits	64
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

CD2L5_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.061877 (rank : 716)
Query Neighborhood Hits	185	Target Neighborhood Hits	987	Shared Neighborhood Hits	45
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CD2L5_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.062674 (rank : 701)
Query Neighborhood Hits	185	Target Neighborhood Hits	1011	Shared Neighborhood Hits	47
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CD2L6_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.056404 (rank : 818)
Query Neighborhood Hits	185	Target Neighborhood Hits	844	Shared Neighborhood Hits	42
SwissProt Accessions	Q9BWU1, Q5JQZ7, Q5JR00, Q8TC78, Q9UPX2	Gene names	CDC2L6, CDK11, KIAA1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11).

CD2L6_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.056739 (rank : 814)
Query Neighborhood Hits	185	Target Neighborhood Hits	851	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BWD8, Q80TM1	Gene names	Cdc2l6, Kiaa1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6).

CD2L7_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.065919 (rank : 652)
Query Neighborhood Hits	185	Target Neighborhood Hits	1275	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

CDC2_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.068185 (rank : 612)
Query Neighborhood Hits	185	Target Neighborhood Hits	842	Shared Neighborhood Hits	40
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDC2_MOUSE
θ value	θ > 10 (rank : 251)	NC score	0.068162 (rank : 613)
Query Neighborhood Hits	185	Target Neighborhood Hits	838	Shared Neighborhood Hits	40
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDC7_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.062478 (rank : 705)
Query Neighborhood Hits	185	Target Neighborhood Hits	652	Shared Neighborhood Hits	36
SwissProt Accessions	O00311, O00558	Gene names	CDC7, CDC7L1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (HsCdc7) (huCdc7).

CDC7_MOUSE
θ value	θ > 10 (rank : 253)	NC score	0.073716 (rank : 501)
Query Neighborhood Hits	185	Target Neighborhood Hits	641	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Z0H0, Q9Z2Y7	Gene names	Cdc7, Cdc7l1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (muCdc7).

CDK10_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.063235 (rank : 693)
Query Neighborhood Hits	185	Target Neighborhood Hits	831	Shared Neighborhood Hits	40
SwissProt Accessions	Q15131, Q15130	Gene names	CDK10
Domain Architecture
Description	Cell division protein kinase 10 (EC 2.7.11.22) (Serine/threonine- protein kinase PISSLRE).

CDK2_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.070289 (rank : 575)
Query Neighborhood Hits	185	Target Neighborhood Hits	832	Shared Neighborhood Hits	40
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

CDK2_MOUSE
θ value	θ > 10 (rank : 256)	NC score	0.067983 (rank : 618)
Query Neighborhood Hits	185	Target Neighborhood Hits	828	Shared Neighborhood Hits	40
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

CDK3_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.066116 (rank : 648)
Query Neighborhood Hits	185	Target Neighborhood Hits	843	Shared Neighborhood Hits	40
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

CDK3_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.071295 (rank : 556)
Query Neighborhood Hits	185	Target Neighborhood Hits	829	Shared Neighborhood Hits	40
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

CDK4_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.062029 (rank : 714)
Query Neighborhood Hits	185	Target Neighborhood Hits	834	Shared Neighborhood Hits	40
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

CDK4_MOUSE
θ value	θ > 10 (rank : 260)	NC score	0.061540 (rank : 719)
Query Neighborhood Hits	185	Target Neighborhood Hits	838	Shared Neighborhood Hits	40
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

CDK5_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.065294 (rank : 666)
Query Neighborhood Hits	185	Target Neighborhood Hits	826	Shared Neighborhood Hits	40
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

CDK5_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.065280 (rank : 667)
Query Neighborhood Hits	185	Target Neighborhood Hits	826	Shared Neighborhood Hits	40
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

CDK6_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.065653 (rank : 655)
Query Neighborhood Hits	185	Target Neighborhood Hits	837	Shared Neighborhood Hits	40
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

CDK6_MOUSE
θ value	θ > 10 (rank : 264)	NC score	0.066378 (rank : 643)
Query Neighborhood Hits	185	Target Neighborhood Hits	837	Shared Neighborhood Hits	40
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

CDK7_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.065576 (rank : 658)
Query Neighborhood Hits	185	Target Neighborhood Hits	833	Shared Neighborhood Hits	40
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

CDK7_MOUSE
θ value	θ > 10 (rank : 266)	NC score	0.065717 (rank : 654)
Query Neighborhood Hits	185	Target Neighborhood Hits	835	Shared Neighborhood Hits	40
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

CDK8_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.055448 (rank : 832)
Query Neighborhood Hits	185	Target Neighborhood Hits	831	Shared Neighborhood Hits	41
SwissProt Accessions	P49336	Gene names	CDK8
Domain Architecture
Description	Cell division protein kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Protein kinase K35).

CDK9_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.054525 (rank : 843)
Query Neighborhood Hits	185	Target Neighborhood Hits	822	Shared Neighborhood Hits	40
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

CDK9_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.054672 (rank : 841)
Query Neighborhood Hits	185	Target Neighborhood Hits	822	Shared Neighborhood Hits	40
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

CDKL1_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.066238 (rank : 646)
Query Neighborhood Hits	185	Target Neighborhood Hits	830	Shared Neighborhood Hits	40
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

CDKL1_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.066649 (rank : 639)
Query Neighborhood Hits	185	Target Neighborhood Hits	829	Shared Neighborhood Hits	40
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

CDKL2_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.069156 (rank : 595)
Query Neighborhood Hits	185	Target Neighborhood Hits	838	Shared Neighborhood Hits	40
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

CDKL2_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.069697 (rank : 584)
Query Neighborhood Hits	185	Target Neighborhood Hits	854	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

CDKL3_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.068613 (rank : 606)
Query Neighborhood Hits	185	Target Neighborhood Hits	853	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

CDKL3_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.068911 (rank : 598)
Query Neighborhood Hits	185	Target Neighborhood Hits	857	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

CDKL4_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.067268 (rank : 631)
Query Neighborhood Hits	185	Target Neighborhood Hits	828	Shared Neighborhood Hits	40
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CDKL4_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.067865 (rank : 619)
Query Neighborhood Hits	185	Target Neighborhood Hits	833	Shared Neighborhood Hits	40
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CDKL5_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.075970 (rank : 457)
Query Neighborhood Hits	185	Target Neighborhood Hits	967	Shared Neighborhood Hits	42
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

CHK1_HUMAN
θ value	θ > 10 (rank : 279)	NC score	0.078707 (rank : 415)
Query Neighborhood Hits	185	Target Neighborhood Hits	843	Shared Neighborhood Hits	40
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

CHK1_MOUSE
θ value	θ > 10 (rank : 280)	NC score	0.078294 (rank : 420)
Query Neighborhood Hits	185	Target Neighborhood Hits	839	Shared Neighborhood Hits	40
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

CHK2_HUMAN
θ value	θ > 10 (rank : 281)	NC score	0.087202 (rank : 302)
Query Neighborhood Hits	185	Target Neighborhood Hits	859	Shared Neighborhood Hits	40
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

CHK2_MOUSE
θ value	θ > 10 (rank : 282)	NC score	0.087176 (rank : 303)
Query Neighborhood Hits	185	Target Neighborhood Hits	860	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

CI096_HUMAN
θ value	θ > 10 (rank : 283)	NC score	0.052164 (rank : 867)
Query Neighborhood Hits	185	Target Neighborhood Hits	821	Shared Neighborhood Hits	40
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

CLK1_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.058862 (rank : 774)
Query Neighborhood Hits	185	Target Neighborhood Hits	756	Shared Neighborhood Hits	40
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

CLK1_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.058451 (rank : 785)
Query Neighborhood Hits	185	Target Neighborhood Hits	760	Shared Neighborhood Hits	40
SwissProt Accessions	P22518	Gene names	Clk1, Clk, Sty
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY).

CLK2_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.057456 (rank : 805)
Query Neighborhood Hits	185	Target Neighborhood Hits	752	Shared Neighborhood Hits	40
SwissProt Accessions	P49760, Q96CQ0	Gene names	CLK2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

CLK2_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.054640 (rank : 842)
Query Neighborhood Hits	185	Target Neighborhood Hits	743	Shared Neighborhood Hits	40
SwissProt Accessions	O35491	Gene names	Clk2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

CLK3_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.055724 (rank : 826)
Query Neighborhood Hits	185	Target Neighborhood Hits	748	Shared Neighborhood Hits	39
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK3_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.055691 (rank : 827)
Query Neighborhood Hits	185	Target Neighborhood Hits	761	Shared Neighborhood Hits	39
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK4_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.052289 (rank : 865)
Query Neighborhood Hits	185	Target Neighborhood Hits	759	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HAZ1	Gene names	CLK4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

CLK4_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.052713 (rank : 857)
Query Neighborhood Hits	185	Target Neighborhood Hits	759	Shared Neighborhood Hits	40
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

CSK21_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.067781 (rank : 621)
Query Neighborhood Hits	185	Target Neighborhood Hits	772	Shared Neighborhood Hits	39
SwissProt Accessions	P68400, P19138, P20426, Q14013	Gene names	CSNK2A1, CK2A1
Domain Architecture	No domain graphic available
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

CSK21_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.068763 (rank : 601)
Query Neighborhood Hits	185	Target Neighborhood Hits	770	Shared Neighborhood Hits	39
SwissProt Accessions	Q60737	Gene names	Csnk2a1, Ckiia
Domain Architecture
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

CSK22_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.068859 (rank : 600)
Query Neighborhood Hits	185	Target Neighborhood Hits	758	Shared Neighborhood Hits	39
SwissProt Accessions	P19784	Gene names	CSNK2A2, CK2A2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

CSK22_MOUSE
θ value	θ > 10 (rank : 295)	NC score	0.068628 (rank : 605)
Query Neighborhood Hits	185	Target Neighborhood Hits	758	Shared Neighborhood Hits	39
SwissProt Accessions	O54833	Gene names	Csnk2a2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

CSKP_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.101420 (rank : 209)
Query Neighborhood Hits	185	Target Neighborhood Hits	1022	Shared Neighborhood Hits	64
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKP_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.100413 (rank : 213)
Query Neighborhood Hits	185	Target Neighborhood Hits	1027	Shared Neighborhood Hits	65
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

CSK_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.058579 (rank : 779)
Query Neighborhood Hits	185	Target Neighborhood Hits	1009	Shared Neighborhood Hits	50
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	θ > 10 (rank : 299)	NC score	0.059480 (rank : 768)
Query Neighborhood Hits	185	Target Neighborhood Hits	1009	Shared Neighborhood Hits	50
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

DAPK1_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.070294 (rank : 574)
Query Neighborhood Hits	185	Target Neighborhood Hits	1130	Shared Neighborhood Hits	41
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DAPK1_MOUSE
θ value	θ > 10 (rank : 301)	NC score	0.070275 (rank : 576)
Query Neighborhood Hits	185	Target Neighborhood Hits	1138	Shared Neighborhood Hits	41
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DAPK2_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.082752 (rank : 377)
Query Neighborhood Hits	185	Target Neighborhood Hits	832	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK2_MOUSE
θ value	θ > 10 (rank : 303)	NC score	0.083883 (rank : 351)
Query Neighborhood Hits	185	Target Neighborhood Hits	834	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK3_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.081459 (rank : 394)
Query Neighborhood Hits	185	Target Neighborhood Hits	945	Shared Neighborhood Hits	46
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DAPK3_MOUSE
θ value	θ > 10 (rank : 305)	NC score	0.080636 (rank : 397)
Query Neighborhood Hits	185	Target Neighborhood Hits	843	Shared Neighborhood Hits	41
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DCAK1_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.083254 (rank : 364)
Query Neighborhood Hits	185	Target Neighborhood Hits	877	Shared Neighborhood Hits	43
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DCAK1_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.082757 (rank : 375)
Query Neighborhood Hits	185	Target Neighborhood Hits	867	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DCAK2_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.085170 (rank : 331)
Query Neighborhood Hits	185	Target Neighborhood Hits	862	Shared Neighborhood Hits	40
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

DCAK2_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.084473 (rank : 346)
Query Neighborhood Hits	185	Target Neighborhood Hits	858	Shared Neighborhood Hits	40
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

DCAK3_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.091601 (rank : 241)
Query Neighborhood Hits	185	Target Neighborhood Hits	888	Shared Neighborhood Hits	41
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

DCAK3_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.090698 (rank : 251)
Query Neighborhood Hits	185	Target Neighborhood Hits	922	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

DGKA_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.146432 (rank : 57)
Query Neighborhood Hits	185	Target Neighborhood Hits	151	Shared Neighborhood Hits	51
SwissProt Accessions	P23743, O75481, O75482, O75483	Gene names	DGKA, DAGK, DAGK1
Domain Architecture
Description	Diacylglycerol kinase alpha (EC 2.7.1.107) (Diglyceride kinase alpha) (DGK-alpha) (DAG kinase alpha) (80 kDa diacylglycerol kinase).

DGKD_HUMAN
θ value	θ > 10 (rank : 313)	NC score	0.182719 (rank : 27)
Query Neighborhood Hits	185	Target Neighborhood Hits	231	Shared Neighborhood Hits	55
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

DGKE_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.068499 (rank : 608)
Query Neighborhood Hits	185	Target Neighborhood Hits	32	Shared Neighborhood Hits	13
SwissProt Accessions	P52429, Q9UKQ3	Gene names	DGKE, DAGK5
Domain Architecture
Description	Diacylglycerol kinase epsilon (EC 2.7.1.107) (Diglyceride kinase epsilon) (DGK-epsilon) (DAG kinase epsilon).

DGKE_MOUSE
θ value	θ > 10 (rank : 315)	NC score	0.062447 (rank : 706)
Query Neighborhood Hits	185	Target Neighborhood Hits	30	Shared Neighborhood Hits	13
SwissProt Accessions	Q9R1C6	Gene names	Dgke
Domain Architecture
Description	Diacylglycerol kinase epsilon (EC 2.7.1.107) (Diglyceride kinase epsilon) (DGK-epsilon) (DAG kinase epsilon).

DGKH_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.180906 (rank : 28)
Query Neighborhood Hits	185	Target Neighborhood Hits	255	Shared Neighborhood Hits	57
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

DGKK_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.104707 (rank : 189)
Query Neighborhood Hits	185	Target Neighborhood Hits	378	Shared Neighborhood Hits	42
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

DLG4_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.132394 (rank : 74)
Query Neighborhood Hits	185	Target Neighborhood Hits	286	Shared Neighborhood Hits	48
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_MOUSE
θ value	θ > 10 (rank : 319)	NC score	0.132416 (rank : 73)
Query Neighborhood Hits	185	Target Neighborhood Hits	282	Shared Neighborhood Hits	48
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG5_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.100288 (rank : 215)
Query Neighborhood Hits	185	Target Neighborhood Hits	1088	Shared Neighborhood Hits	68
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

DMPK_HUMAN
θ value	θ > 10 (rank : 321)	NC score	0.122383 (rank : 91)
Query Neighborhood Hits	185	Target Neighborhood Hits	944	Shared Neighborhood Hits	48
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

DMPK_MOUSE
θ value	θ > 10 (rank : 322)	NC score	0.122001 (rank : 95)
Query Neighborhood Hits	185	Target Neighborhood Hits	908	Shared Neighborhood Hits	46
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

DOC2B_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.052678 (rank : 859)
Query Neighborhood Hits	185	Target Neighborhood Hits	150	Shared Neighborhood Hits	15
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2B_MOUSE
θ value	θ > 10 (rank : 324)	NC score	0.052050 (rank : 869)
Query Neighborhood Hits	185	Target Neighborhood Hits	169	Shared Neighborhood Hits	16
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DUET_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.081879 (rank : 388)
Query Neighborhood Hits	185	Target Neighborhood Hits	1220	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

DYR1A_HUMAN
θ value	θ > 10 (rank : 326)	NC score	0.077971 (rank : 424)
Query Neighborhood Hits	185	Target Neighborhood Hits	764	Shared Neighborhood Hits	40
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

DYR1A_MOUSE
θ value	θ > 10 (rank : 327)	NC score	0.077959 (rank : 426)
Query Neighborhood Hits	185	Target Neighborhood Hits	762	Shared Neighborhood Hits	40
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

DYR1B_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.077769 (rank : 428)
Query Neighborhood Hits	185	Target Neighborhood Hits	831	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

DYR1B_MOUSE
θ value	θ > 10 (rank : 329)	NC score	0.076263 (rank : 451)
Query Neighborhood Hits	185	Target Neighborhood Hits	799	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

DYRK2_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.075839 (rank : 461)
Query Neighborhood Hits	185	Target Neighborhood Hits	799	Shared Neighborhood Hits	40
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

DYRK3_HUMAN
θ value	θ > 10 (rank : 331)	NC score	0.072085 (rank : 534)
Query Neighborhood Hits	185	Target Neighborhood Hits	798	Shared Neighborhood Hits	40
SwissProt Accessions	O43781	Gene names	DYRK3
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1).

DYRK4_HUMAN
θ value	θ > 10 (rank : 332)	NC score	0.065307 (rank : 665)
Query Neighborhood Hits	185	Target Neighborhood Hits	750	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NR20, Q8NEF2, Q92631	Gene names	DYRK4
Domain Architecture	No domain graphic available
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1).

E2AK1_HUMAN
θ value	θ > 10 (rank : 333)	NC score	0.063625 (rank : 688)
Query Neighborhood Hits	185	Target Neighborhood Hits	833	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

E2AK1_MOUSE
θ value	θ > 10 (rank : 334)	NC score	0.066978 (rank : 638)
Query Neighborhood Hits	185	Target Neighborhood Hits	821	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

E2AK2_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.073719 (rank : 499)
Query Neighborhood Hits	185	Target Neighborhood Hits	856	Shared Neighborhood Hits	40
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

E2AK2_MOUSE
θ value	θ > 10 (rank : 336)	NC score	0.079582 (rank : 402)
Query Neighborhood Hits	185	Target Neighborhood Hits	864	Shared Neighborhood Hits	40
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

E2AK3_HUMAN
θ value	θ > 10 (rank : 337)	NC score	0.062380 (rank : 708)
Query Neighborhood Hits	185	Target Neighborhood Hits	859	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

E2AK3_MOUSE
θ value	θ > 10 (rank : 338)	NC score	0.063008 (rank : 697)
Query Neighborhood Hits	185	Target Neighborhood Hits	851	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

E2AK4_HUMAN
θ value	θ > 10 (rank : 339)	NC score	0.072234 (rank : 531)
Query Neighborhood Hits	185	Target Neighborhood Hits	1012	Shared Neighborhood Hits	49
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

E2AK4_MOUSE
θ value	θ > 10 (rank : 340)	NC score	0.073474 (rank : 506)
Query Neighborhood Hits	185	Target Neighborhood Hits	984	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

EM55_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.062302 (rank : 709)
Query Neighborhood Hits	185	Target Neighborhood Hits	228	Shared Neighborhood Hits	31
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

EM55_MOUSE
θ value	θ > 10 (rank : 342)	NC score	0.062228 (rank : 711)
Query Neighborhood Hits	185	Target Neighborhood Hits	221	Shared Neighborhood Hits	30
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

ERN1_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.065556 (rank : 659)
Query Neighborhood Hits	185	Target Neighborhood Hits	829	Shared Neighborhood Hits	40
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

ERN1_MOUSE
θ value	θ > 10 (rank : 344)	NC score	0.066008 (rank : 650)
Query Neighborhood Hits	185	Target Neighborhood Hits	823	Shared Neighborhood Hits	40
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

ERN2_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.065634 (rank : 657)
Query Neighborhood Hits	185	Target Neighborhood Hits	844	Shared Neighborhood Hits	41
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

ERN2_MOUSE
θ value	θ > 10 (rank : 346)	NC score	0.071187 (rank : 557)
Query Neighborhood Hits	185	Target Neighborhood Hits	825	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

F5006_HUMAN
θ value	θ > 10 (rank : 347)	NC score	0.105046 (rank : 186)
Query Neighborhood Hits	185	Target Neighborhood Hits	794	Shared Neighborhood Hits	40
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

F5006_MOUSE
θ value	θ > 10 (rank : 348)	NC score	0.103694 (rank : 194)
Query Neighborhood Hits	185	Target Neighborhood Hits	793	Shared Neighborhood Hits	40
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

FA62A_HUMAN
θ value	θ > 10 (rank : 349)	NC score	0.053786 (rank : 848)
Query Neighborhood Hits	185	Target Neighborhood Hits	168	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

FAK2_HUMAN
θ value	θ > 10 (rank : 350)	NC score	0.050962 (rank : 885)
Query Neighborhood Hits	185	Target Neighborhood Hits	847	Shared Neighborhood Hits	40
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_MOUSE
θ value	θ > 10 (rank : 351)	NC score	0.051072 (rank : 882)
Query Neighborhood Hits	185	Target Neighborhood Hits	851	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FER_HUMAN
θ value	θ > 10 (rank : 352)	NC score	0.059733 (rank : 760)
Query Neighborhood Hits	185	Target Neighborhood Hits	1278	Shared Neighborhood Hits	57
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FES_HUMAN
θ value	θ > 10 (rank : 353)	NC score	0.056403 (rank : 819)
Query Neighborhood Hits	185	Target Neighborhood Hits	978	Shared Neighborhood Hits	44
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_MOUSE
θ value	θ > 10 (rank : 354)	NC score	0.056102 (rank : 823)
Query Neighborhood Hits	185	Target Neighborhood Hits	980	Shared Neighborhood Hits	44
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGR_HUMAN
θ value	θ > 10 (rank : 355)	NC score	0.052702 (rank : 858)
Query Neighborhood Hits	185	Target Neighborhood Hits	1067	Shared Neighborhood Hits	57
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FNBP2_HUMAN
θ value	θ > 10 (rank : 356)	NC score	0.050851 (rank : 887)
Query Neighborhood Hits	185	Target Neighborhood Hits	432	Shared Neighborhood Hits	33
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

FRK_HUMAN
θ value	θ > 10 (rank : 357)	NC score	0.059002 (rank : 773)
Query Neighborhood Hits	185	Target Neighborhood Hits	1058	Shared Neighborhood Hits	58
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

FYN_HUMAN
θ value	θ > 10 (rank : 358)	NC score	0.056937 (rank : 810)
Query Neighborhood Hits	185	Target Neighborhood Hits	1078	Shared Neighborhood Hits	56
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	θ > 10 (rank : 359)	NC score	0.054998 (rank : 838)
Query Neighborhood Hits	185	Target Neighborhood Hits	1073	Shared Neighborhood Hits	56
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

GAK_HUMAN
θ value	θ > 10 (rank : 360)	NC score	0.056165 (rank : 822)
Query Neighborhood Hits	185	Target Neighborhood Hits	1028	Shared Neighborhood Hits	42
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

GAK_MOUSE
θ value	θ > 10 (rank : 361)	NC score	0.058486 (rank : 782)
Query Neighborhood Hits	185	Target Neighborhood Hits	964	Shared Neighborhood Hits	43
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

GMIP_MOUSE
θ value	θ > 10 (rank : 362)	NC score	0.093598 (rank : 231)
Query Neighborhood Hits	185	Target Neighborhood Hits	202	Shared Neighborhood Hits	40
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

GOPC_HUMAN
θ value	θ > 10 (rank : 363)	NC score	0.075739 (rank : 463)
Query Neighborhood Hits	185	Target Neighborhood Hits	377	Shared Neighborhood Hits	45
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

GOPC_MOUSE
θ value	θ > 10 (rank : 364)	NC score	0.076876 (rank : 441)
Query Neighborhood Hits	185	Target Neighborhood Hits	323	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

GRASP_HUMAN
θ value	θ > 10 (rank : 365)	NC score	0.083729 (rank : 353)
Query Neighborhood Hits	185	Target Neighborhood Hits	147	Shared Neighborhood Hits	35
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

GRASP_MOUSE
θ value	θ > 10 (rank : 366)	NC score	0.083761 (rank : 352)
Query Neighborhood Hits	185	Target Neighborhood Hits	131	Shared Neighborhood Hits	37
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

GRIP2_HUMAN
θ value	θ > 10 (rank : 367)	NC score	0.103289 (rank : 198)
Query Neighborhood Hits	185	Target Neighborhood Hits	256	Shared Neighborhood Hits	45
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

GRK4_HUMAN
θ value	θ > 10 (rank : 368)	NC score	0.113888 (rank : 134)
Query Neighborhood Hits	185	Target Neighborhood Hits	822	Shared Neighborhood Hits	40
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

GRK4_MOUSE
θ value	θ > 10 (rank : 369)	NC score	0.114158 (rank : 132)
Query Neighborhood Hits	185	Target Neighborhood Hits	808	Shared Neighborhood Hits	40
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

GRK5_HUMAN
θ value	θ > 10 (rank : 370)	NC score	0.112227 (rank : 151)
Query Neighborhood Hits	185	Target Neighborhood Hits	819	Shared Neighborhood Hits	40
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK5_MOUSE
θ value	θ > 10 (rank : 371)	NC score	0.112201 (rank : 152)
Query Neighborhood Hits	185	Target Neighborhood Hits	823	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK6_HUMAN
θ value	θ > 10 (rank : 372)	NC score	0.109723 (rank : 164)
Query Neighborhood Hits	185	Target Neighborhood Hits	823	Shared Neighborhood Hits	40
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

GRK6_MOUSE
θ value	θ > 10 (rank : 373)	NC score	0.110707 (rank : 160)
Query Neighborhood Hits	185	Target Neighborhood Hits	820	Shared Neighborhood Hits	40
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

GRK7_HUMAN
θ value	θ > 10 (rank : 374)	NC score	0.112885 (rank : 143)
Query Neighborhood Hits	185	Target Neighborhood Hits	820	Shared Neighborhood Hits	40
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

GRLF1_HUMAN
θ value	θ > 10 (rank : 375)	NC score	0.055600 (rank : 828)
Query Neighborhood Hits	185	Target Neighborhood Hits	167	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

GSK3A_HUMAN
θ value	θ > 10 (rank : 376)	NC score	0.072540 (rank : 525)
Query Neighborhood Hits	185	Target Neighborhood Hits	835	Shared Neighborhood Hits	40
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

GSK3B_HUMAN
θ value	θ > 10 (rank : 377)	NC score	0.070614 (rank : 569)
Query Neighborhood Hits	185	Target Neighborhood Hits	801	Shared Neighborhood Hits	40
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_MOUSE
θ value	θ > 10 (rank : 378)	NC score	0.070614 (rank : 570)
Query Neighborhood Hits	185	Target Neighborhood Hits	800	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

HCK_HUMAN
θ value	θ > 10 (rank : 379)	NC score	0.052655 (rank : 860)
Query Neighborhood Hits	185	Target Neighborhood Hits	1035	Shared Neighborhood Hits	48
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

HCK_MOUSE
θ value	θ > 10 (rank : 380)	NC score	0.051595 (rank : 877)
Query Neighborhood Hits	185	Target Neighborhood Hits	1029	Shared Neighborhood Hits	47
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

HIPK1_HUMAN
θ value	θ > 10 (rank : 381)	NC score	0.073739 (rank : 498)
Query Neighborhood Hits	185	Target Neighborhood Hits	843	Shared Neighborhood Hits	47
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

HIPK1_MOUSE
θ value	θ > 10 (rank : 382)	NC score	0.073529 (rank : 504)
Query Neighborhood Hits	185	Target Neighborhood Hits	838	Shared Neighborhood Hits	44
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

HIPK2_HUMAN
θ value	θ > 10 (rank : 383)	NC score	0.075132 (rank : 477)
Query Neighborhood Hits	185	Target Neighborhood Hits	845	Shared Neighborhood Hits	43
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

HIPK2_MOUSE
θ value	θ > 10 (rank : 384)	NC score	0.075311 (rank : 471)
Query Neighborhood Hits	185	Target Neighborhood Hits	871	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

HIPK3_HUMAN
θ value	θ > 10 (rank : 385)	NC score	0.072195 (rank : 533)
Query Neighborhood Hits	185	Target Neighborhood Hits	867	Shared Neighborhood Hits	43
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

HIPK3_MOUSE
θ value	θ > 10 (rank : 386)	NC score	0.072536 (rank : 526)
Query Neighborhood Hits	185	Target Neighborhood Hits	857	Shared Neighborhood Hits	42
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

HIPK4_HUMAN
θ value	θ > 10 (rank : 387)	NC score	0.071502 (rank : 551)
Query Neighborhood Hits	185	Target Neighborhood Hits	799	Shared Neighborhood Hits	40
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

HUNK_HUMAN
θ value	θ > 10 (rank : 388)	NC score	0.088433 (rank : 284)
Query Neighborhood Hits	185	Target Neighborhood Hits	884	Shared Neighborhood Hits	40
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

HUNK_MOUSE
θ value	θ > 10 (rank : 389)	NC score	0.088381 (rank : 286)
Query Neighborhood Hits	185	Target Neighborhood Hits	874	Shared Neighborhood Hits	41
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

ICK_HUMAN
θ value	θ > 10 (rank : 390)	NC score	0.064730 (rank : 678)
Query Neighborhood Hits	185	Target Neighborhood Hits	867	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

ICK_MOUSE
θ value	θ > 10 (rank : 391)	NC score	0.065190 (rank : 669)
Query Neighborhood Hits	185	Target Neighborhood Hits	860	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

IKKA_HUMAN
θ value	θ > 10 (rank : 392)	NC score	0.077300 (rank : 433)
Query Neighborhood Hits	185	Target Neighborhood Hits	863	Shared Neighborhood Hits	40
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKA_MOUSE
θ value	θ > 10 (rank : 393)	NC score	0.077277 (rank : 435)
Query Neighborhood Hits	185	Target Neighborhood Hits	867	Shared Neighborhood Hits	41
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKB_HUMAN
θ value	θ > 10 (rank : 394)	NC score	0.077389 (rank : 431)
Query Neighborhood Hits	185	Target Neighborhood Hits	980	Shared Neighborhood Hits	44
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKB_MOUSE
θ value	θ > 10 (rank : 395)	NC score	0.077298 (rank : 434)
Query Neighborhood Hits	185	Target Neighborhood Hits	984	Shared Neighborhood Hits	45
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKE_HUMAN
θ value	θ > 10 (rank : 396)	NC score	0.074747 (rank : 485)
Query Neighborhood Hits	185	Target Neighborhood Hits	837	Shared Neighborhood Hits	41
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

IKKE_MOUSE
θ value	θ > 10 (rank : 397)	NC score	0.070667 (rank : 565)
Query Neighborhood Hits	185	Target Neighborhood Hits	848	Shared Neighborhood Hits	41
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

IL16_HUMAN
θ value	θ > 10 (rank : 398)	NC score	0.072408 (rank : 530)
Query Neighborhood Hits	185	Target Neighborhood Hits	207	Shared Neighborhood Hits	35
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

IL16_MOUSE
θ value	θ > 10 (rank : 399)	NC score	0.066993 (rank : 637)
Query Neighborhood Hits	185	Target Neighborhood Hits	189	Shared Neighborhood Hits	32
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

INADL_HUMAN
θ value	θ > 10 (rank : 400)	NC score	0.109395 (rank : 168)
Query Neighborhood Hits	185	Target Neighborhood Hits	260	Shared Neighborhood Hits	43
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

IRAK1_HUMAN
θ value	θ > 10 (rank : 401)	NC score	0.065528 (rank : 660)
Query Neighborhood Hits	185	Target Neighborhood Hits	820	Shared Neighborhood Hits	46
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

IRAK1_MOUSE
θ value	θ > 10 (rank : 402)	NC score	0.070153 (rank : 579)
Query Neighborhood Hits	185	Target Neighborhood Hits	784	Shared Neighborhood Hits	41
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

IRAK4_HUMAN
θ value	θ > 10 (rank : 403)	NC score	0.061120 (rank : 727)
Query Neighborhood Hits	185	Target Neighborhood Hits	816	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

IRAK4_MOUSE
θ value	θ > 10 (rank : 404)	NC score	0.064771 (rank : 676)
Query Neighborhood Hits	185	Target Neighborhood Hits	820	Shared Neighborhood Hits	41
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

ITK_HUMAN
θ value	θ > 10 (rank : 405)	NC score	0.052967 (rank : 854)
Query Neighborhood Hits	185	Target Neighborhood Hits	1016	Shared Neighborhood Hits	44
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
θ value	θ > 10 (rank : 406)	NC score	0.052914 (rank : 855)
Query Neighborhood Hits	185	Target Neighborhood Hits	985	Shared Neighborhood Hits	43
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

ITSN1_MOUSE
θ value	θ > 10 (rank : 407)	NC score	0.050125 (rank : 901)
Query Neighborhood Hits	185	Target Neighborhood Hits	1669	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
θ value	θ > 10 (rank : 408)	NC score	0.052547 (rank : 861)
Query Neighborhood Hits	185	Target Neighborhood Hits	1173	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

JAK1_HUMAN
θ value	θ > 10 (rank : 409)	NC score	0.050631 (rank : 894)
Query Neighborhood Hits	185	Target Neighborhood Hits	858	Shared Neighborhood Hits	41
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK2_HUMAN
θ value	θ > 10 (rank : 410)	NC score	0.051866 (rank : 872)
Query Neighborhood Hits	185	Target Neighborhood Hits	847	Shared Neighborhood Hits	40
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_MOUSE
θ value	θ > 10 (rank : 411)	NC score	0.051950 (rank : 871)
Query Neighborhood Hits	185	Target Neighborhood Hits	839	Shared Neighborhood Hits	40
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK3_HUMAN
θ value	θ > 10 (rank : 412)	NC score	0.059087 (rank : 771)
Query Neighborhood Hits	185	Target Neighborhood Hits	827	Shared Neighborhood Hits	40
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

JAK3_MOUSE
θ value	θ > 10 (rank : 413)	NC score	0.059971 (rank : 755)
Query Neighborhood Hits	185	Target Neighborhood Hits	821	Shared Neighborhood Hits	41
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

K0999_HUMAN
θ value	θ > 10 (rank : 414)	NC score	0.084498 (rank : 344)
Query Neighborhood Hits	185	Target Neighborhood Hits	899	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

K0999_MOUSE
θ value	θ > 10 (rank : 415)	NC score	0.084593 (rank : 340)
Query Neighborhood Hits	185	Target Neighborhood Hits	931	Shared Neighborhood Hits	44
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

K1849_HUMAN
θ value	θ > 10 (rank : 416)	NC score	0.075207 (rank : 473)
Query Neighborhood Hits	185	Target Neighborhood Hits	220	Shared Neighborhood Hits	44
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

K1849_MOUSE
θ value	θ > 10 (rank : 417)	NC score	0.068690 (rank : 604)
Query Neighborhood Hits	185	Target Neighborhood Hits	335	Shared Neighborhood Hits	42
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

K2002_HUMAN
θ value	θ > 10 (rank : 418)	NC score	0.055559 (rank : 829)
Query Neighborhood Hits	185	Target Neighborhood Hits	274	Shared Neighborhood Hits	27
SwissProt Accessions	Q9H792, Q6ZS78, Q8NCM3	Gene names	KIAA2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

K2002_MOUSE
θ value	θ > 10 (rank : 419)	NC score	0.059058 (rank : 772)
Query Neighborhood Hits	185	Target Neighborhood Hits	267	Shared Neighborhood Hits	27
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

KAPCA_HUMAN
θ value	θ > 10 (rank : 420)	NC score	0.112174 (rank : 153)
Query Neighborhood Hits	185	Target Neighborhood Hits	838	Shared Neighborhood Hits	40
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KAPCA_MOUSE
θ value	θ > 10 (rank : 421)	NC score	0.112375 (rank : 146)
Query Neighborhood Hits	185	Target Neighborhood Hits	836	Shared Neighborhood Hits	40
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KAPCB_HUMAN
θ value	θ > 10 (rank : 422)	NC score	0.112923 (rank : 142)
Query Neighborhood Hits	185	Target Neighborhood Hits	837	Shared Neighborhood Hits	40
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KAPCB_MOUSE
θ value	θ > 10 (rank : 423)	NC score	0.113167 (rank : 140)
Query Neighborhood Hits	185	Target Neighborhood Hits	836	Shared Neighborhood Hits	40
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KAPCG_HUMAN
θ value	θ > 10 (rank : 424)	NC score	0.109146 (rank : 169)
Query Neighborhood Hits	185	Target Neighborhood Hits	845	Shared Neighborhood Hits	40
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

KC1AL_HUMAN
θ value	θ > 10 (rank : 425)	NC score	0.059838 (rank : 758)
Query Neighborhood Hits	185	Target Neighborhood Hits	734	Shared Neighborhood Hits	40
SwissProt Accessions	Q8N752	Gene names	CSNK1A1L
Domain Architecture
Description	Casein kinase I isoform alpha-like (EC 2.7.11.1) (CKI-alpha-like) (CK1).

KC1D_HUMAN
θ value	θ > 10 (rank : 426)	NC score	0.050814 (rank : 889)
Query Neighborhood Hits	185	Target Neighborhood Hits	737	Shared Neighborhood Hits	40
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
θ value	θ > 10 (rank : 427)	NC score	0.050813 (rank : 890)
Query Neighborhood Hits	185	Target Neighborhood Hits	737	Shared Neighborhood Hits	40
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1E_HUMAN
θ value	θ > 10 (rank : 428)	NC score	0.051728 (rank : 876)
Query Neighborhood Hits	185	Target Neighborhood Hits	732	Shared Neighborhood Hits	40
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1E_MOUSE
θ value	θ > 10 (rank : 429)	NC score	0.051730 (rank : 875)
Query Neighborhood Hits	185	Target Neighborhood Hits	728	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1G1_HUMAN
θ value	θ > 10 (rank : 430)	NC score	0.061856 (rank : 717)
Query Neighborhood Hits	185	Target Neighborhood Hits	708	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HCP0, Q96AE9, Q9HCP1	Gene names	CSNK1G1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

KC1G1_MOUSE
θ value	θ > 10 (rank : 431)	NC score	0.061382 (rank : 721)
Query Neighborhood Hits	185	Target Neighborhood Hits	713	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BTH8	Gene names	Csnk1g1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

KC1G2_HUMAN
θ value	θ > 10 (rank : 432)	NC score	0.058676 (rank : 777)
Query Neighborhood Hits	185	Target Neighborhood Hits	693	Shared Neighborhood Hits	40
SwissProt Accessions	P78368, O00704, Q8WUB1	Gene names	CSNK1G2
Domain Architecture
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

KC1G2_MOUSE
θ value	θ > 10 (rank : 433)	NC score	0.060466 (rank : 742)
Query Neighborhood Hits	185	Target Neighborhood Hits	695	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BVP5	Gene names	Csnk1g2
Domain Architecture	No domain graphic available
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

KC1G3_HUMAN
θ value	θ > 10 (rank : 434)	NC score	0.060294 (rank : 747)
Query Neighborhood Hits	185	Target Neighborhood Hits	711	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y6M4, Q86WZ7, Q9Y6M3	Gene names	CSNK1G3
Domain Architecture
Description	Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma 3).

KCC1A_HUMAN
θ value	θ > 10 (rank : 435)	NC score	0.088975 (rank : 271)
Query Neighborhood Hits	185	Target Neighborhood Hits	846	Shared Neighborhood Hits	40
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1A_MOUSE
θ value	θ > 10 (rank : 436)	NC score	0.088687 (rank : 279)
Query Neighborhood Hits	185	Target Neighborhood Hits	845	Shared Neighborhood Hits	40
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1B_HUMAN
θ value	θ > 10 (rank : 437)	NC score	0.089508 (rank : 263)
Query Neighborhood Hits	185	Target Neighborhood Hits	842	Shared Neighborhood Hits	40
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

KCC1B_MOUSE
θ value	θ > 10 (rank : 438)	NC score	0.089591 (rank : 262)
Query Neighborhood Hits	185	Target Neighborhood Hits	842	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

KCC1D_HUMAN
θ value	θ > 10 (rank : 439)	NC score	0.090457 (rank : 252)
Query Neighborhood Hits	185	Target Neighborhood Hits	846	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

KCC1D_MOUSE
θ value	θ > 10 (rank : 440)	NC score	0.090457 (rank : 253)
Query Neighborhood Hits	185	Target Neighborhood Hits	847	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

KCC1G_HUMAN
θ value	θ > 10 (rank : 441)	NC score	0.088989 (rank : 270)
Query Neighborhood Hits	185	Target Neighborhood Hits	850	Shared Neighborhood Hits	40
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC1G_MOUSE
θ value	θ > 10 (rank : 442)	NC score	0.089201 (rank : 269)
Query Neighborhood Hits	185	Target Neighborhood Hits	851	Shared Neighborhood Hits	40
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC2A_HUMAN
θ value	θ > 10 (rank : 443)	NC score	0.083150 (rank : 366)
Query Neighborhood Hits	185	Target Neighborhood Hits	830	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KCC2A_MOUSE
θ value	θ > 10 (rank : 444)	NC score	0.083272 (rank : 363)
Query Neighborhood Hits	185	Target Neighborhood Hits	829	Shared Neighborhood Hits	40
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KCC2B_HUMAN
θ value	θ > 10 (rank : 445)	NC score	0.083075 (rank : 369)
Query Neighborhood Hits	185	Target Neighborhood Hits	866	Shared Neighborhood Hits	42
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

KCC2B_MOUSE
θ value	θ > 10 (rank : 446)	NC score	0.082529 (rank : 381)
Query Neighborhood Hits	185	Target Neighborhood Hits	841	Shared Neighborhood Hits	40
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

KCC2D_HUMAN
θ value	θ > 10 (rank : 447)	NC score	0.083557 (rank : 357)
Query Neighborhood Hits	185	Target Neighborhood Hits	830	Shared Neighborhood Hits	40
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

KCC2G_HUMAN
θ value	θ > 10 (rank : 448)	NC score	0.083707 (rank : 354)
Query Neighborhood Hits	185	Target Neighborhood Hits	841	Shared Neighborhood Hits	41
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2G_MOUSE
θ value	θ > 10 (rank : 449)	NC score	0.083656 (rank : 356)
Query Neighborhood Hits	185	Target Neighborhood Hits	838	Shared Neighborhood Hits	40
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC4_HUMAN
θ value	θ > 10 (rank : 450)	NC score	0.089875 (rank : 258)
Query Neighborhood Hits	185	Target Neighborhood Hits	841	Shared Neighborhood Hits	40
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KCC4_MOUSE
θ value	θ > 10 (rank : 451)	NC score	0.091133 (rank : 246)
Query Neighborhood Hits	185	Target Neighborhood Hits	899	Shared Neighborhood Hits	42
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KGP1A_HUMAN
θ value	θ > 10 (rank : 452)	NC score	0.107933 (rank : 178)
Query Neighborhood Hits	185	Target Neighborhood Hits	901	Shared Neighborhood Hits	41
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_HUMAN
θ value	θ > 10 (rank : 453)	NC score	0.107819 (rank : 180)
Query Neighborhood Hits	185	Target Neighborhood Hits	921	Shared Neighborhood Hits	42
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_MOUSE
θ value	θ > 10 (rank : 454)	NC score	0.107838 (rank : 179)
Query Neighborhood Hits	185	Target Neighborhood Hits	922	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP2_HUMAN
θ value	θ > 10 (rank : 455)	NC score	0.104515 (rank : 191)
Query Neighborhood Hits	185	Target Neighborhood Hits	1023	Shared Neighborhood Hits	42
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KGP2_MOUSE
θ value	θ > 10 (rank : 456)	NC score	0.104923 (rank : 187)
Query Neighborhood Hits	185	Target Neighborhood Hits	1029	Shared Neighborhood Hits	43
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KGUA_HUMAN
θ value	θ > 10 (rank : 457)	NC score	0.056758 (rank : 813)
Query Neighborhood Hits	185	Target Neighborhood Hits	41	Shared Neighborhood Hits	6
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KGUA_MOUSE
θ value	θ > 10 (rank : 458)	NC score	0.058337 (rank : 787)
Query Neighborhood Hits	185	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KKCC1_HUMAN
θ value	θ > 10 (rank : 459)	NC score	0.087655 (rank : 299)
Query Neighborhood Hits	185	Target Neighborhood Hits	858	Shared Neighborhood Hits	41
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KKCC1_MOUSE
θ value	θ > 10 (rank : 460)	NC score	0.088735 (rank : 277)
Query Neighborhood Hits	185	Target Neighborhood Hits	866	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KKCC2_HUMAN
θ value	θ > 10 (rank : 461)	NC score	0.086042 (rank : 316)
Query Neighborhood Hits	185	Target Neighborhood Hits	852	Shared Neighborhood Hits	40
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_MOUSE
θ value	θ > 10 (rank : 462)	NC score	0.086122 (rank : 315)
Query Neighborhood Hits	185	Target Neighborhood Hits	855	Shared Neighborhood Hits	40
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KPSH1_HUMAN
θ value	θ > 10 (rank : 463)	NC score	0.088134 (rank : 291)
Query Neighborhood Hits	185	Target Neighborhood Hits	842	Shared Neighborhood Hits	41
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KPSH1_MOUSE
θ value	θ > 10 (rank : 464)	NC score	0.088166 (rank : 289)
Query Neighborhood Hits	185	Target Neighborhood Hits	839	Shared Neighborhood Hits	40
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KPSH2_HUMAN
θ value	θ > 10 (rank : 465)	NC score	0.089501 (rank : 264)
Query Neighborhood Hits	185	Target Neighborhood Hits	822	Shared Neighborhood Hits	40
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

KS6A1_HUMAN
θ value	θ > 10 (rank : 466)	NC score	0.102737 (rank : 202)
Query Neighborhood Hits	185	Target Neighborhood Hits	854	Shared Neighborhood Hits	40
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A1_MOUSE
θ value	θ > 10 (rank : 467)	NC score	0.103170 (rank : 199)
Query Neighborhood Hits	185	Target Neighborhood Hits	850	Shared Neighborhood Hits	40
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A2_HUMAN
θ value	θ > 10 (rank : 468)	NC score	0.102031 (rank : 207)
Query Neighborhood Hits	185	Target Neighborhood Hits	857	Shared Neighborhood Hits	40
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

KS6A2_MOUSE
θ value	θ > 10 (rank : 469)	NC score	0.101488 (rank : 208)
Query Neighborhood Hits	185	Target Neighborhood Hits	858	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

KS6A3_HUMAN
θ value	θ > 10 (rank : 470)	NC score	0.102596 (rank : 206)
Query Neighborhood Hits	185	Target Neighborhood Hits	859	Shared Neighborhood Hits	40
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_MOUSE
θ value	θ > 10 (rank : 471)	NC score	0.102619 (rank : 204)
Query Neighborhood Hits	185	Target Neighborhood Hits	860	Shared Neighborhood Hits	40
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A4_HUMAN
θ value	θ > 10 (rank : 472)	NC score	0.111685 (rank : 155)
Query Neighborhood Hits	185	Target Neighborhood Hits	868	Shared Neighborhood Hits	40
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

KS6A4_MOUSE
θ value	θ > 10 (rank : 473)	NC score	0.111611 (rank : 157)
Query Neighborhood Hits	185	Target Neighborhood Hits	866	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

KS6A5_HUMAN
θ value	θ > 10 (rank : 474)	NC score	0.109122 (rank : 170)
Query Neighborhood Hits	185	Target Neighborhood Hits	855	Shared Neighborhood Hits	40
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

KS6A5_MOUSE
θ value	θ > 10 (rank : 475)	NC score	0.112718 (rank : 144)
Query Neighborhood Hits	185	Target Neighborhood Hits	854	Shared Neighborhood Hits	40
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

KS6A6_HUMAN
θ value	θ > 10 (rank : 476)	NC score	0.102936 (rank : 200)
Query Neighborhood Hits	185	Target Neighborhood Hits	853	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

KS6B1_HUMAN
θ value	θ > 10 (rank : 477)	NC score	0.112369 (rank : 147)
Query Neighborhood Hits	185	Target Neighborhood Hits	850	Shared Neighborhood Hits	40
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B1_MOUSE
θ value	θ > 10 (rank : 478)	NC score	0.112366 (rank : 148)
Query Neighborhood Hits	185	Target Neighborhood Hits	849	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

KS6B2_HUMAN
θ value	θ > 10 (rank : 479)	NC score	0.112676 (rank : 145)
Query Neighborhood Hits	185	Target Neighborhood Hits	858	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

KS6B2_MOUSE
θ value	θ > 10 (rank : 480)	NC score	0.113584 (rank : 136)
Query Neighborhood Hits	185	Target Neighborhood Hits	871	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

KS6C1_HUMAN
θ value	θ > 10 (rank : 481)	NC score	0.121078 (rank : 97)
Query Neighborhood Hits	185	Target Neighborhood Hits	682	Shared Neighborhood Hits	40
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

KS6C1_MOUSE
θ value	θ > 10 (rank : 482)	NC score	0.123618 (rank : 90)
Query Neighborhood Hits	185	Target Neighborhood Hits	700	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

KSR1_HUMAN
θ value	θ > 10 (rank : 483)	NC score	0.060854 (rank : 738)
Query Neighborhood Hits	185	Target Neighborhood Hits	867	Shared Neighborhood Hits	53
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KSR1_MOUSE
θ value	θ > 10 (rank : 484)	NC score	0.065342 (rank : 662)
Query Neighborhood Hits	185	Target Neighborhood Hits	870	Shared Neighborhood Hits	53
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

KSR2_HUMAN
θ value	θ > 10 (rank : 485)	NC score	0.065161 (rank : 671)
Query Neighborhood Hits	185	Target Neighborhood Hits	920	Shared Neighborhood Hits	70
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

KSYK_HUMAN
θ value	θ > 10 (rank : 486)	NC score	0.058021 (rank : 793)
Query Neighborhood Hits	185	Target Neighborhood Hits	901	Shared Neighborhood Hits	45
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 487)	NC score	0.057615 (rank : 803)
Query Neighborhood Hits	185	Target Neighborhood Hits	944	Shared Neighborhood Hits	47
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LAP4_HUMAN
θ value	θ > 10 (rank : 488)	NC score	0.074364 (rank : 491)
Query Neighborhood Hits	185	Target Neighborhood Hits	608	Shared Neighborhood Hits	49
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

LAP4_MOUSE
θ value	θ > 10 (rank : 489)	NC score	0.073614 (rank : 502)
Query Neighborhood Hits	185	Target Neighborhood Hits	590	Shared Neighborhood Hits	50
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

LATS1_HUMAN
θ value	θ > 10 (rank : 490)	NC score	0.120032 (rank : 101)
Query Neighborhood Hits	185	Target Neighborhood Hits	1057	Shared Neighborhood Hits	55
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

LATS1_MOUSE
θ value	θ > 10 (rank : 491)	NC score	0.120592 (rank : 99)
Query Neighborhood Hits	185	Target Neighborhood Hits	1027	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

LATS2_HUMAN
θ value	θ > 10 (rank : 492)	NC score	0.117080 (rank : 123)
Query Neighborhood Hits	185	Target Neighborhood Hits	884	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

LATS2_MOUSE
θ value	θ > 10 (rank : 493)	NC score	0.117739 (rank : 115)
Query Neighborhood Hits	185	Target Neighborhood Hits	879	Shared Neighborhood Hits	41
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

LBC_HUMAN
θ value	θ > 10 (rank : 494)	NC score	0.050063 (rank : 903)
Query Neighborhood Hits	185	Target Neighborhood Hits	90	Shared Neighborhood Hits	10
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

LCK_MOUSE
θ value	θ > 10 (rank : 495)	NC score	0.051819 (rank : 873)
Query Neighborhood Hits	185	Target Neighborhood Hits	981	Shared Neighborhood Hits	48
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LIMK1_HUMAN
θ value	θ > 10 (rank : 496)	NC score	0.069568 (rank : 591)
Query Neighborhood Hits	185	Target Neighborhood Hits	1005	Shared Neighborhood Hits	54
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
θ value	θ > 10 (rank : 497)	NC score	0.068726 (rank : 602)
Query Neighborhood Hits	185	Target Neighborhood Hits	1008	Shared Neighborhood Hits	52
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

LIMK2_HUMAN
θ value	θ > 10 (rank : 498)	NC score	0.068195 (rank : 611)
Query Neighborhood Hits	185	Target Neighborhood Hits	986	Shared Neighborhood Hits	60
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK2_MOUSE
θ value	θ > 10 (rank : 499)	NC score	0.068987 (rank : 597)
Query Neighborhood Hits	185	Target Neighborhood Hits	998	Shared Neighborhood Hits	61
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIN7A_HUMAN
θ value	θ > 10 (rank : 500)	NC score	0.095807 (rank : 225)
Query Neighborhood Hits	185	Target Neighborhood Hits	193	Shared Neighborhood Hits	45
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7A_MOUSE
θ value	θ > 10 (rank : 501)	NC score	0.095860 (rank : 224)
Query Neighborhood Hits	185	Target Neighborhood Hits	193	Shared Neighborhood Hits	45
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

LIN7B_HUMAN
θ value	θ > 10 (rank : 502)	NC score	0.093946 (rank : 229)
Query Neighborhood Hits	185	Target Neighborhood Hits	200	Shared Neighborhood Hits	43
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

LIN7B_MOUSE
θ value	θ > 10 (rank : 503)	NC score	0.092817 (rank : 237)
Query Neighborhood Hits	185	Target Neighborhood Hits	200	Shared Neighborhood Hits	43
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

LIN7C_HUMAN
θ value	θ > 10 (rank : 504)	NC score	0.093540 (rank : 232)
Query Neighborhood Hits	185	Target Neighborhood Hits	198	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
θ value	θ > 10 (rank : 505)	NC score	0.093540 (rank : 233)
Query Neighborhood Hits	185	Target Neighborhood Hits	198	Shared Neighborhood Hits	43
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LNX1_HUMAN
θ value	θ > 10 (rank : 506)	NC score	0.088015 (rank : 292)
Query Neighborhood Hits	185	Target Neighborhood Hits	379	Shared Neighborhood Hits	38
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

LNX1_MOUSE
θ value	θ > 10 (rank : 507)	NC score	0.087937 (rank : 294)
Query Neighborhood Hits	185	Target Neighborhood Hits	377	Shared Neighborhood Hits	43
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

LNX2_HUMAN
θ value	θ > 10 (rank : 508)	NC score	0.088900 (rank : 272)
Query Neighborhood Hits	185	Target Neighborhood Hits	389	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

LNX2_MOUSE
θ value	θ > 10 (rank : 509)	NC score	0.092993 (rank : 236)
Query Neighborhood Hits	185	Target Neighborhood Hits	407	Shared Neighborhood Hits	45
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

LRRK1_HUMAN
θ value	θ > 10 (rank : 510)	NC score	0.070662 (rank : 566)
Query Neighborhood Hits	185	Target Neighborhood Hits	1237	Shared Neighborhood Hits	39
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK1_MOUSE
θ value	θ > 10 (rank : 511)	NC score	0.067645 (rank : 625)
Query Neighborhood Hits	185	Target Neighborhood Hits	1267	Shared Neighborhood Hits	38
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK2_HUMAN
θ value	θ > 10 (rank : 512)	NC score	0.061418 (rank : 720)
Query Neighborhood Hits	185	Target Neighborhood Hits	1382	Shared Neighborhood Hits	41
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

LRRK2_MOUSE
θ value	θ > 10 (rank : 513)	NC score	0.058553 (rank : 780)
Query Neighborhood Hits	185	Target Neighborhood Hits	1359	Shared Neighborhood Hits	41
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

LYN_HUMAN
θ value	θ > 10 (rank : 514)	NC score	0.054240 (rank : 846)
Query Neighborhood Hits	185	Target Neighborhood Hits	1022	Shared Neighborhood Hits	46
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_MOUSE
θ value	θ > 10 (rank : 515)	NC score	0.053726 (rank : 849)
Query Neighborhood Hits	185	Target Neighborhood Hits	1023	Shared Neighborhood Hits	46
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

M3K10_HUMAN
θ value	θ > 10 (rank : 516)	NC score	0.071038 (rank : 559)
Query Neighborhood Hits	185	Target Neighborhood Hits	1071	Shared Neighborhood Hits	59
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K11_HUMAN
θ value	θ > 10 (rank : 517)	NC score	0.075616 (rank : 466)
Query Neighborhood Hits	185	Target Neighborhood Hits	1136	Shared Neighborhood Hits	56
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3K12_HUMAN
θ value	θ > 10 (rank : 518)	NC score	0.065168 (rank : 670)
Query Neighborhood Hits	185	Target Neighborhood Hits	940	Shared Neighborhood Hits	46
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	θ > 10 (rank : 519)	NC score	0.064499 (rank : 680)
Query Neighborhood Hits	185	Target Neighborhood Hits	957	Shared Neighborhood Hits	46
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K13_HUMAN
θ value	θ > 10 (rank : 520)	NC score	0.067035 (rank : 634)
Query Neighborhood Hits	185	Target Neighborhood Hits	911	Shared Neighborhood Hits	40
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

M3K14_HUMAN
θ value	θ > 10 (rank : 521)	NC score	0.090282 (rank : 256)
Query Neighborhood Hits	185	Target Neighborhood Hits	887	Shared Neighborhood Hits	50
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

M3K14_MOUSE
θ value	θ > 10 (rank : 522)	NC score	0.088666 (rank : 280)
Query Neighborhood Hits	185	Target Neighborhood Hits	889	Shared Neighborhood Hits	45
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

M3K15_HUMAN
θ value	θ > 10 (rank : 523)	NC score	0.077171 (rank : 438)
Query Neighborhood Hits	185	Target Neighborhood Hits	914	Shared Neighborhood Hits	44
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

M3K1_MOUSE
θ value	θ > 10 (rank : 524)	NC score	0.074990 (rank : 480)
Query Neighborhood Hits	185	Target Neighborhood Hits	952	Shared Neighborhood Hits	44
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

M3K2_HUMAN
θ value	θ > 10 (rank : 525)	NC score	0.075255 (rank : 472)
Query Neighborhood Hits	185	Target Neighborhood Hits	849	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K2_MOUSE
θ value	θ > 10 (rank : 526)	NC score	0.073461 (rank : 507)
Query Neighborhood Hits	185	Target Neighborhood Hits	846	Shared Neighborhood Hits	41
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K3_HUMAN
θ value	θ > 10 (rank : 527)	NC score	0.075202 (rank : 474)
Query Neighborhood Hits	185	Target Neighborhood Hits	885	Shared Neighborhood Hits	40
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K3_MOUSE
θ value	θ > 10 (rank : 528)	NC score	0.075364 (rank : 470)
Query Neighborhood Hits	185	Target Neighborhood Hits	876	Shared Neighborhood Hits	40
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K4_HUMAN
θ value	θ > 10 (rank : 529)	NC score	0.072794 (rank : 520)
Query Neighborhood Hits	185	Target Neighborhood Hits	911	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

M3K4_MOUSE
θ value	θ > 10 (rank : 530)	NC score	0.072535 (rank : 527)
Query Neighborhood Hits	185	Target Neighborhood Hits	924	Shared Neighborhood Hits	45
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

M3K5_HUMAN
θ value	θ > 10 (rank : 531)	NC score	0.076461 (rank : 442)
Query Neighborhood Hits	185	Target Neighborhood Hits	868	Shared Neighborhood Hits	41
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K5_MOUSE
θ value	θ > 10 (rank : 532)	NC score	0.076453 (rank : 443)
Query Neighborhood Hits	185	Target Neighborhood Hits	867	Shared Neighborhood Hits	40
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K6_HUMAN
θ value	θ > 10 (rank : 533)	NC score	0.078930 (rank : 410)
Query Neighborhood Hits	185	Target Neighborhood Hits	889	Shared Neighborhood Hits	43
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

M3K7_HUMAN
θ value	θ > 10 (rank : 534)	NC score	0.060919 (rank : 733)
Query Neighborhood Hits	185	Target Neighborhood Hits	892	Shared Neighborhood Hits	41
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_MOUSE
θ value	θ > 10 (rank : 535)	NC score	0.061005 (rank : 729)
Query Neighborhood Hits	185	Target Neighborhood Hits	892	Shared Neighborhood Hits	42
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K8_HUMAN
θ value	θ > 10 (rank : 536)	NC score	0.069570 (rank : 590)
Query Neighborhood Hits	185	Target Neighborhood Hits	807	Shared Neighborhood Hits	40
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

M3K8_MOUSE
θ value	θ > 10 (rank : 537)	NC score	0.070169 (rank : 577)
Query Neighborhood Hits	185	Target Neighborhood Hits	815	Shared Neighborhood Hits	40
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

M3K9_HUMAN
θ value	θ > 10 (rank : 538)	NC score	0.069866 (rank : 582)
Query Neighborhood Hits	185	Target Neighborhood Hits	1123	Shared Neighborhood Hits	53
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3KL4_HUMAN
θ value	θ > 10 (rank : 539)	NC score	0.067491 (rank : 630)
Query Neighborhood Hits	185	Target Neighborhood Hits	1087	Shared Neighborhood Hits	56
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

M4K1_HUMAN
θ value	θ > 10 (rank : 540)	NC score	0.071158 (rank : 558)
Query Neighborhood Hits	185	Target Neighborhood Hits	884	Shared Neighborhood Hits	40
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

M4K1_MOUSE
θ value	θ > 10 (rank : 541)	NC score	0.070845 (rank : 563)
Query Neighborhood Hits	185	Target Neighborhood Hits	858	Shared Neighborhood Hits	40
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

M4K2_HUMAN
θ value	θ > 10 (rank : 542)	NC score	0.075178 (rank : 475)
Query Neighborhood Hits	185	Target Neighborhood Hits	850	Shared Neighborhood Hits	41
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

M4K2_MOUSE
θ value	θ > 10 (rank : 543)	NC score	0.075065 (rank : 478)
Query Neighborhood Hits	185	Target Neighborhood Hits	843	Shared Neighborhood Hits	40
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

M4K3_HUMAN
θ value	θ > 10 (rank : 544)	NC score	0.076928 (rank : 440)
Query Neighborhood Hits	185	Target Neighborhood Hits	857	Shared Neighborhood Hits	41
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

M4K4_HUMAN
θ value	θ > 10 (rank : 545)	NC score	0.073189 (rank : 511)
Query Neighborhood Hits	185	Target Neighborhood Hits	1589	Shared Neighborhood Hits	64
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

M4K4_MOUSE
θ value	θ > 10 (rank : 546)	NC score	0.073063 (rank : 515)
Query Neighborhood Hits	185	Target Neighborhood Hits	1560	Shared Neighborhood Hits	64
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

M4K5_HUMAN
θ value	θ > 10 (rank : 547)	NC score	0.073179 (rank : 512)
Query Neighborhood Hits	185	Target Neighborhood Hits	845	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

M4K5_MOUSE
θ value	θ > 10 (rank : 548)	NC score	0.073440 (rank : 508)
Query Neighborhood Hits	185	Target Neighborhood Hits	839	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

MAGI1_HUMAN
θ value	θ > 10 (rank : 549)	NC score	0.092093 (rank : 240)
Query Neighborhood Hits	185	Target Neighborhood Hits	388	Shared Neighborhood Hits	47
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI1_MOUSE
θ value	θ > 10 (rank : 550)	NC score	0.092766 (rank : 238)
Query Neighborhood Hits	185	Target Neighborhood Hits	403	Shared Neighborhood Hits	48
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MAGI2_HUMAN
θ value	θ > 10 (rank : 551)	NC score	0.089410 (rank : 267)
Query Neighborhood Hits	185	Target Neighborhood Hits	373	Shared Neighborhood Hits	54
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MAGI2_MOUSE
θ value	θ > 10 (rank : 552)	NC score	0.088848 (rank : 275)
Query Neighborhood Hits	185	Target Neighborhood Hits	370	Shared Neighborhood Hits	52
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

MAK_HUMAN
θ value	θ > 10 (rank : 553)	NC score	0.065648 (rank : 656)
Query Neighborhood Hits	185	Target Neighborhood Hits	857	Shared Neighborhood Hits	40
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

MAK_MOUSE
θ value	θ > 10 (rank : 554)	NC score	0.066066 (rank : 649)
Query Neighborhood Hits	185	Target Neighborhood Hits	873	Shared Neighborhood Hits	42
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

MAPK2_HUMAN
θ value	θ > 10 (rank : 555)	NC score	0.085019 (rank : 335)
Query Neighborhood Hits	185	Target Neighborhood Hits	844	Shared Neighborhood Hits	41
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MAPK2_MOUSE
θ value	θ > 10 (rank : 556)	NC score	0.084768 (rank : 338)
Query Neighborhood Hits	185	Target Neighborhood Hits	831	Shared Neighborhood Hits	41
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MAPK3_HUMAN
θ value	θ > 10 (rank : 557)	NC score	0.085719 (rank : 322)
Query Neighborhood Hits	185	Target Neighborhood Hits	807	Shared Neighborhood Hits	40
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

MAPK3_MOUSE
θ value	θ > 10 (rank : 558)	NC score	0.085443 (rank : 326)
Query Neighborhood Hits	185	Target Neighborhood Hits	811	Shared Neighborhood Hits	40
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

MAPK5_HUMAN
θ value	θ > 10 (rank : 559)	NC score	0.088847 (rank : 276)
Query Neighborhood Hits	185	Target Neighborhood Hits	795	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

MAPK5_MOUSE
θ value	θ > 10 (rank : 560)	NC score	0.088869 (rank : 274)
Query Neighborhood Hits	185	Target Neighborhood Hits	799	Shared Neighborhood Hits	40
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

MARK1_HUMAN
θ value	θ > 10 (rank : 561)	NC score	0.084735 (rank : 339)
Query Neighborhood Hits	185	Target Neighborhood Hits	887	Shared Neighborhood Hits	40
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

MARK1_MOUSE
θ value	θ > 10 (rank : 562)	NC score	0.085064 (rank : 334)
Query Neighborhood Hits	185	Target Neighborhood Hits	886	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

MARK2_HUMAN
θ value	θ > 10 (rank : 563)	NC score	0.085692 (rank : 323)
Query Neighborhood Hits	185	Target Neighborhood Hits	1056	Shared Neighborhood Hits	46
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

MARK2_MOUSE
θ value	θ > 10 (rank : 564)	NC score	0.086283 (rank : 314)
Query Neighborhood Hits	185	Target Neighborhood Hits	1018	Shared Neighborhood Hits	46
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

MARK3_HUMAN
θ value	θ > 10 (rank : 565)	NC score	0.085529 (rank : 325)
Query Neighborhood Hits	185	Target Neighborhood Hits	893	Shared Neighborhood Hits	43
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

MARK3_MOUSE
θ value	θ > 10 (rank : 566)	NC score	0.085013 (rank : 336)
Query Neighborhood Hits	185	Target Neighborhood Hits	919	Shared Neighborhood Hits	42
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

MARK4_HUMAN
θ value	θ > 10 (rank : 567)	NC score	0.085356 (rank : 328)
Query Neighborhood Hits	185	Target Neighborhood Hits	886	Shared Neighborhood Hits	41
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MARK4_MOUSE
θ value	θ > 10 (rank : 568)	NC score	0.085254 (rank : 330)
Query Neighborhood Hits	185	Target Neighborhood Hits	898	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

MASTL_HUMAN
θ value	θ > 10 (rank : 569)	NC score	0.108356 (rank : 174)
Query Neighborhood Hits	185	Target Neighborhood Hits	894	Shared Neighborhood Hits	40
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

MASTL_MOUSE
θ value	θ > 10 (rank : 570)	NC score	0.108186 (rank : 176)
Query Neighborhood Hits	185	Target Neighborhood Hits	862	Shared Neighborhood Hits	42
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

MATK_HUMAN
θ value	θ > 10 (rank : 571)	NC score	0.052055 (rank : 868)
Query Neighborhood Hits	185	Target Neighborhood Hits	954	Shared Neighborhood Hits	46
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	θ > 10 (rank : 572)	NC score	0.052277 (rank : 866)
Query Neighborhood Hits	185	Target Neighborhood Hits	952	Shared Neighborhood Hits	46
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MELK_HUMAN
θ value	θ > 10 (rank : 573)	NC score	0.086405 (rank : 310)
Query Neighborhood Hits	185	Target Neighborhood Hits	847	Shared Neighborhood Hits	40
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

MELK_MOUSE
θ value	θ > 10 (rank : 574)	NC score	0.086372 (rank : 311)
Query Neighborhood Hits	185	Target Neighborhood Hits	860	Shared Neighborhood Hits	41
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

MET_HUMAN
θ value	θ > 10 (rank : 575)	NC score	0.050457 (rank : 896)
Query Neighborhood Hits	185	Target Neighborhood Hits	831	Shared Neighborhood Hits	40
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MET_MOUSE
θ value	θ > 10 (rank : 576)	NC score	0.052295 (rank : 864)
Query Neighborhood Hits	185	Target Neighborhood Hits	844	Shared Neighborhood Hits	41
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MINK1_HUMAN
θ value	θ > 10 (rank : 577)	NC score	0.072645 (rank : 522)
Query Neighborhood Hits	185	Target Neighborhood Hits	1477	Shared Neighborhood Hits	69
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_MOUSE
θ value	θ > 10 (rank : 578)	NC score	0.072224 (rank : 532)
Query Neighborhood Hits	185	Target Neighborhood Hits	1451	Shared Neighborhood Hits	65
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MK01_HUMAN
θ value	θ > 10 (rank : 579)	NC score	0.059523 (rank : 765)
Query Neighborhood Hits	185	Target Neighborhood Hits	836	Shared Neighborhood Hits	40
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK01_MOUSE
θ value	θ > 10 (rank : 580)	NC score	0.059420 (rank : 770)
Query Neighborhood Hits	185	Target Neighborhood Hits	836	Shared Neighborhood Hits	40
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK03_HUMAN
θ value	θ > 10 (rank : 581)	NC score	0.059521 (rank : 766)
Query Neighborhood Hits	185	Target Neighborhood Hits	837	Shared Neighborhood Hits	40
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

MK03_MOUSE
θ value	θ > 10 (rank : 582)	NC score	0.059866 (rank : 757)
Query Neighborhood Hits	185	Target Neighborhood Hits	840	Shared Neighborhood Hits	40
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

MK04_HUMAN
θ value	θ > 10 (rank : 583)	NC score	0.057780 (rank : 796)
Query Neighborhood Hits	185	Target Neighborhood Hits	837	Shared Neighborhood Hits	40
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

MK04_MOUSE
θ value	θ > 10 (rank : 584)	NC score	0.056211 (rank : 821)
Query Neighborhood Hits	185	Target Neighborhood Hits	852	Shared Neighborhood Hits	40
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

MK06_HUMAN
θ value	θ > 10 (rank : 585)	NC score	0.058015 (rank : 794)
Query Neighborhood Hits	185	Target Neighborhood Hits	815	Shared Neighborhood Hits	41
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

MK06_MOUSE
θ value	θ > 10 (rank : 586)	NC score	0.057402 (rank : 806)
Query Neighborhood Hits	185	Target Neighborhood Hits	818	Shared Neighborhood Hits	41
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

MK07_HUMAN
θ value	θ > 10 (rank : 587)	NC score	0.062266 (rank : 710)
Query Neighborhood Hits	185	Target Neighborhood Hits	1087	Shared Neighborhood Hits	55
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

MK07_MOUSE
θ value	θ > 10 (rank : 588)	NC score	0.062864 (rank : 700)
Query Neighborhood Hits	185	Target Neighborhood Hits	1054	Shared Neighborhood Hits	57
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

MK08_HUMAN
θ value	θ > 10 (rank : 589)	NC score	0.063101 (rank : 696)
Query Neighborhood Hits	185	Target Neighborhood Hits	834	Shared Neighborhood Hits	40
SwissProt Accessions	P45983, Q15709, Q15712, Q15713	Gene names	MAPK8, JNK1, PRKM8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46).

MK08_MOUSE
θ value	θ > 10 (rank : 590)	NC score	0.063173 (rank : 695)
Query Neighborhood Hits	185	Target Neighborhood Hits	834	Shared Neighborhood Hits	40
SwissProt Accessions	Q91Y86	Gene names	Mapk8, Jnk1, Prkm8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1).

MK09_HUMAN
θ value	θ > 10 (rank : 591)	NC score	0.063524 (rank : 689)
Query Neighborhood Hits	185	Target Neighborhood Hits	842	Shared Neighborhood Hits	41
SwissProt Accessions	P45984, Q15708, Q15710, Q15711, Q8N5C5	Gene names	MAPK9, JNK2, PRKM9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).

MK09_MOUSE
θ value	θ > 10 (rank : 592)	NC score	0.062484 (rank : 704)
Query Neighborhood Hits	185	Target Neighborhood Hits	843	Shared Neighborhood Hits	42
SwissProt Accessions	Q9WTU6, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5	Gene names	Mapk9, Jnk2, Prkm9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2).

MK10_HUMAN
θ value	θ > 10 (rank : 593)	NC score	0.061725 (rank : 718)
Query Neighborhood Hits	185	Target Neighborhood Hits	836	Shared Neighborhood Hits	40
SwissProt Accessions	P53779, Q15707	Gene names	MAPK10, JNK3, JNK3A, PRKM10
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

MK10_MOUSE
θ value	θ > 10 (rank : 594)	NC score	0.061218 (rank : 726)
Query Neighborhood Hits	185	Target Neighborhood Hits	849	Shared Neighborhood Hits	40
SwissProt Accessions	Q61831, Q9R0U6	Gene names	Mapk10, Jnk3, Prkm10, Serk2
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

MK11_HUMAN
θ value	θ > 10 (rank : 595)	NC score	0.059980 (rank : 754)
Query Neighborhood Hits	185	Target Neighborhood Hits	823	Shared Neighborhood Hits	40
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

MK11_MOUSE
θ value	θ > 10 (rank : 596)	NC score	0.060725 (rank : 739)
Query Neighborhood Hits	185	Target Neighborhood Hits	835	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

MK12_HUMAN
θ value	θ > 10 (rank : 597)	NC score	0.060340 (rank : 745)
Query Neighborhood Hits	185	Target Neighborhood Hits	830	Shared Neighborhood Hits	40
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MK12_MOUSE
θ value	θ > 10 (rank : 598)	NC score	0.058636 (rank : 778)
Query Neighborhood Hits	185	Target Neighborhood Hits	835	Shared Neighborhood Hits	40
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MK13_HUMAN
θ value	θ > 10 (rank : 599)	NC score	0.060236 (rank : 749)
Query Neighborhood Hits	185	Target Neighborhood Hits	829	Shared Neighborhood Hits	41
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK13_MOUSE
θ value	θ > 10 (rank : 600)	NC score	0.060973 (rank : 730)
Query Neighborhood Hits	185	Target Neighborhood Hits	832	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK14_HUMAN
θ value	θ > 10 (rank : 601)	NC score	0.060194 (rank : 750)
Query Neighborhood Hits	185	Target Neighborhood Hits	838	Shared Neighborhood Hits	40
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

MK14_MOUSE
θ value	θ > 10 (rank : 602)	NC score	0.060690 (rank : 740)
Query Neighborhood Hits	185	Target Neighborhood Hits	838	Shared Neighborhood Hits	40
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

MK15_HUMAN
θ value	θ > 10 (rank : 603)	NC score	0.066124 (rank : 647)
Query Neighborhood Hits	185	Target Neighborhood Hits	1038	Shared Neighborhood Hits	46
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

MK15_MOUSE
θ value	θ > 10 (rank : 604)	NC score	0.069425 (rank : 593)
Query Neighborhood Hits	185	Target Neighborhood Hits	843	Shared Neighborhood Hits	44
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

MKNK1_HUMAN
θ value	θ > 10 (rank : 605)	NC score	0.092216 (rank : 239)
Query Neighborhood Hits	185	Target Neighborhood Hits	701	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

MKNK1_MOUSE
θ value	θ > 10 (rank : 606)	NC score	0.090363 (rank : 254)
Query Neighborhood Hits	185	Target Neighborhood Hits	811	Shared Neighborhood Hits	40
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

MKNK2_HUMAN
θ value	θ > 10 (rank : 607)	NC score	0.087628 (rank : 300)
Query Neighborhood Hits	185	Target Neighborhood Hits	821	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

MKNK2_MOUSE
θ value	θ > 10 (rank : 608)	NC score	0.087687 (rank : 298)
Query Neighborhood Hits	185	Target Neighborhood Hits	819	Shared Neighborhood Hits	40
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

MLTK_HUMAN
θ value	θ > 10 (rank : 609)	NC score	0.063434 (rank : 690)
Query Neighborhood Hits	185	Target Neighborhood Hits	911	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MLTK_MOUSE
θ value	θ > 10 (rank : 610)	NC score	0.063956 (rank : 686)
Query Neighborhood Hits	185	Target Neighborhood Hits	874	Shared Neighborhood Hits	42
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MOK_HUMAN
θ value	θ > 10 (rank : 611)	NC score	0.057706 (rank : 797)
Query Neighborhood Hits	185	Target Neighborhood Hits	807	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

MOK_MOUSE
θ value	θ > 10 (rank : 612)	NC score	0.057652 (rank : 801)
Query Neighborhood Hits	185	Target Neighborhood Hits	796	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

MOS_HUMAN
θ value	θ > 10 (rank : 613)	NC score	0.067037 (rank : 633)
Query Neighborhood Hits	185	Target Neighborhood Hits	829	Shared Neighborhood Hits	40
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MOS_MOUSE
θ value	θ > 10 (rank : 614)	NC score	0.062207 (rank : 712)
Query Neighborhood Hits	185	Target Neighborhood Hits	833	Shared Neighborhood Hits	40
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MP2K1_HUMAN
θ value	θ > 10 (rank : 615)	NC score	0.079036 (rank : 408)
Query Neighborhood Hits	185	Target Neighborhood Hits	826	Shared Neighborhood Hits	40
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_MOUSE
θ value	θ > 10 (rank : 616)	NC score	0.078952 (rank : 409)
Query Neighborhood Hits	185	Target Neighborhood Hits	826	Shared Neighborhood Hits	40
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K2_HUMAN
θ value	θ > 10 (rank : 617)	NC score	0.078777 (rank : 413)
Query Neighborhood Hits	185	Target Neighborhood Hits	830	Shared Neighborhood Hits	40
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K2_MOUSE
θ value	θ > 10 (rank : 618)	NC score	0.078226 (rank : 422)
Query Neighborhood Hits	185	Target Neighborhood Hits	828	Shared Neighborhood Hits	40
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K3_HUMAN
θ value	θ > 10 (rank : 619)	NC score	0.071741 (rank : 547)
Query Neighborhood Hits	185	Target Neighborhood Hits	825	Shared Neighborhood Hits	40
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K3_MOUSE
θ value	θ > 10 (rank : 620)	NC score	0.074725 (rank : 486)
Query Neighborhood Hits	185	Target Neighborhood Hits	826	Shared Neighborhood Hits	40
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K4_HUMAN
θ value	θ > 10 (rank : 621)	NC score	0.069528 (rank : 592)
Query Neighborhood Hits	185	Target Neighborhood Hits	832	Shared Neighborhood Hits	40
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K4_MOUSE
θ value	θ > 10 (rank : 622)	NC score	0.069588 (rank : 589)
Query Neighborhood Hits	185	Target Neighborhood Hits	833	Shared Neighborhood Hits	40
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

MP2K5_HUMAN
θ value	θ > 10 (rank : 623)	NC score	0.075417 (rank : 468)
Query Neighborhood Hits	185	Target Neighborhood Hits	837	Shared Neighborhood Hits	40
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K5_MOUSE
θ value	θ > 10 (rank : 624)	NC score	0.077047 (rank : 439)
Query Neighborhood Hits	185	Target Neighborhood Hits	840	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K6_HUMAN
θ value	θ > 10 (rank : 625)	NC score	0.069302 (rank : 594)
Query Neighborhood Hits	185	Target Neighborhood Hits	830	Shared Neighborhood Hits	40
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K6_MOUSE
θ value	θ > 10 (rank : 626)	NC score	0.068563 (rank : 607)
Query Neighborhood Hits	185	Target Neighborhood Hits	830	Shared Neighborhood Hits	40
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K7_HUMAN
θ value	θ > 10 (rank : 627)	NC score	0.078800 (rank : 412)
Query Neighborhood Hits	185	Target Neighborhood Hits	833	Shared Neighborhood Hits	40
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

MPDZ_HUMAN
θ value	θ > 10 (rank : 628)	NC score	0.103582 (rank : 195)
Query Neighborhood Hits	185	Target Neighborhood Hits	261	Shared Neighborhood Hits	46
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

MPDZ_MOUSE
θ value	θ > 10 (rank : 629)	NC score	0.104451 (rank : 192)
Query Neighborhood Hits	185	Target Neighborhood Hits	298	Shared Neighborhood Hits	47
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

MPP2_HUMAN
θ value	θ > 10 (rank : 630)	NC score	0.059692 (rank : 763)
Query Neighborhood Hits	185	Target Neighborhood Hits	173	Shared Neighborhood Hits	23
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

MPP2_MOUSE
θ value	θ > 10 (rank : 631)	NC score	0.060051 (rank : 753)
Query Neighborhood Hits	185	Target Neighborhood Hits	189	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

MPP3_HUMAN
θ value	θ > 10 (rank : 632)	NC score	0.070628 (rank : 567)
Query Neighborhood Hits	185	Target Neighborhood Hits	171	Shared Neighborhood Hits	34
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

MPP3_MOUSE
θ value	θ > 10 (rank : 633)	NC score	0.070609 (rank : 571)
Query Neighborhood Hits	185	Target Neighborhood Hits	165	Shared Neighborhood Hits	33
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

MPP4_HUMAN
θ value	θ > 10 (rank : 634)	NC score	0.078467 (rank : 418)
Query Neighborhood Hits	185	Target Neighborhood Hits	205	Shared Neighborhood Hits	43
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

MPP4_MOUSE
θ value	θ > 10 (rank : 635)	NC score	0.068720 (rank : 603)
Query Neighborhood Hits	185	Target Neighborhood Hits	188	Shared Neighborhood Hits	32
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

MPP5_HUMAN
θ value	θ > 10 (rank : 636)	NC score	0.075137 (rank : 476)
Query Neighborhood Hits	185	Target Neighborhood Hits	231	Shared Neighborhood Hits	33
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	θ > 10 (rank : 637)	NC score	0.074844 (rank : 481)
Query Neighborhood Hits	185	Target Neighborhood Hits	226	Shared Neighborhood Hits	32
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

MPP6_HUMAN
θ value	θ > 10 (rank : 638)	NC score	0.055234 (rank : 834)
Query Neighborhood Hits	185	Target Neighborhood Hits	180	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
θ value	θ > 10 (rank : 639)	NC score	0.055484 (rank : 831)
Query Neighborhood Hits	185	Target Neighborhood Hits	187	Shared Neighborhood Hits	20
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

MRCKA_HUMAN
θ value	θ > 10 (rank : 640)	NC score	0.127687 (rank : 83)
Query Neighborhood Hits	185	Target Neighborhood Hits	1999	Shared Neighborhood Hits	87
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

MRCKG_HUMAN
θ value	θ > 10 (rank : 641)	NC score	0.128545 (rank : 81)
Query Neighborhood Hits	185	Target Neighborhood Hits	1519	Shared Neighborhood Hits	81
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

MRCKG_MOUSE
θ value	θ > 10 (rank : 642)	NC score	0.128027 (rank : 82)
Query Neighborhood Hits	185	Target Neighborhood Hits	1466	Shared Neighborhood Hits	76
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

MST4_HUMAN
θ value	θ > 10 (rank : 643)	NC score	0.071850 (rank : 544)
Query Neighborhood Hits	185	Target Neighborhood Hits	852	Shared Neighborhood Hits	40
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MST4_MOUSE
θ value	θ > 10 (rank : 644)	NC score	0.071882 (rank : 542)
Query Neighborhood Hits	185	Target Neighborhood Hits	860	Shared Neighborhood Hits	40
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

MYLK2_HUMAN
θ value	θ > 10 (rank : 645)	NC score	0.086427 (rank : 308)
Query Neighborhood Hits	185	Target Neighborhood Hits	920	Shared Neighborhood Hits	42
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

MYLK_HUMAN
θ value	θ > 10 (rank : 646)	NC score	0.076361 (rank : 448)
Query Neighborhood Hits	185	Target Neighborhood Hits	1328	Shared Neighborhood Hits	44
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

MYLK_MOUSE
θ value	θ > 10 (rank : 647)	NC score	0.077401 (rank : 430)
Query Neighborhood Hits	185	Target Neighborhood Hits	1489	Shared Neighborhood Hits	51
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

MYO3A_HUMAN
θ value	θ > 10 (rank : 648)	NC score	0.072040 (rank : 535)
Query Neighborhood Hits	185	Target Neighborhood Hits	1033	Shared Neighborhood Hits	45
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

MYO3A_MOUSE
θ value	θ > 10 (rank : 649)	NC score	0.073091 (rank : 513)
Query Neighborhood Hits	185	Target Neighborhood Hits	902	Shared Neighborhood Hits	44
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

MYO3B_HUMAN
θ value	θ > 10 (rank : 650)	NC score	0.076164 (rank : 452)
Query Neighborhood Hits	185	Target Neighborhood Hits	923	Shared Neighborhood Hits	44
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

NEB1_HUMAN
θ value	θ > 10 (rank : 651)	NC score	0.055807 (rank : 825)
Query Neighborhood Hits	185	Target Neighborhood Hits	829	Shared Neighborhood Hits	56
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

NEB2_HUMAN
θ value	θ > 10 (rank : 652)	NC score	0.057691 (rank : 799)
Query Neighborhood Hits	185	Target Neighborhood Hits	883	Shared Neighborhood Hits	59
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEB2_MOUSE
θ value	θ > 10 (rank : 653)	NC score	0.056821 (rank : 811)
Query Neighborhood Hits	185	Target Neighborhood Hits	889	Shared Neighborhood Hits	56
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEK11_HUMAN
θ value	θ > 10 (rank : 654)	NC score	0.079250 (rank : 404)
Query Neighborhood Hits	185	Target Neighborhood Hits	1043	Shared Neighborhood Hits	49
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK11_MOUSE
θ value	θ > 10 (rank : 655)	NC score	0.077922 (rank : 427)
Query Neighborhood Hits	185	Target Neighborhood Hits	875	Shared Neighborhood Hits	41
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK1_HUMAN
θ value	θ > 10 (rank : 656)	NC score	0.077214 (rank : 437)
Query Neighborhood Hits	185	Target Neighborhood Hits	1129	Shared Neighborhood Hits	47
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

NEK1_MOUSE
θ value	θ > 10 (rank : 657)	NC score	0.078900 (rank : 411)
Query Neighborhood Hits	185	Target Neighborhood Hits	1311	Shared Neighborhood Hits	53
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

NEK2_HUMAN
θ value	θ > 10 (rank : 658)	NC score	0.076339 (rank : 449)
Query Neighborhood Hits	185	Target Neighborhood Hits	908	Shared Neighborhood Hits	45
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

NEK2_MOUSE
θ value	θ > 10 (rank : 659)	NC score	0.077762 (rank : 429)
Query Neighborhood Hits	185	Target Neighborhood Hits	876	Shared Neighborhood Hits	44
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

NEK3_HUMAN
θ value	θ > 10 (rank : 660)	NC score	0.081859 (rank : 389)
Query Neighborhood Hits	185	Target Neighborhood Hits	865	Shared Neighborhood Hits	40
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

NEK3_MOUSE
θ value	θ > 10 (rank : 661)	NC score	0.083349 (rank : 361)
Query Neighborhood Hits	185	Target Neighborhood Hits	854	Shared Neighborhood Hits	40
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

NEK4_HUMAN
θ value	θ > 10 (rank : 662)	NC score	0.079038 (rank : 407)
Query Neighborhood Hits	185	Target Neighborhood Hits	883	Shared Neighborhood Hits	40
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

NEK4_MOUSE
θ value	θ > 10 (rank : 663)	NC score	0.078429 (rank : 419)
Query Neighborhood Hits	185	Target Neighborhood Hits	899	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

NEK6_HUMAN
θ value	θ > 10 (rank : 664)	NC score	0.071904 (rank : 538)
Query Neighborhood Hits	185	Target Neighborhood Hits	848	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NEK6_MOUSE
θ value	θ > 10 (rank : 665)	NC score	0.071883 (rank : 541)
Query Neighborhood Hits	185	Target Neighborhood Hits	851	Shared Neighborhood Hits	40
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

NEK7_HUMAN
θ value	θ > 10 (rank : 666)	NC score	0.071369 (rank : 553)
Query Neighborhood Hits	185	Target Neighborhood Hits	846	Shared Neighborhood Hits	40
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK7_MOUSE
θ value	θ > 10 (rank : 667)	NC score	0.071478 (rank : 552)
Query Neighborhood Hits	185	Target Neighborhood Hits	847	Shared Neighborhood Hits	40
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK8_HUMAN
θ value	θ > 10 (rank : 668)	NC score	0.075685 (rank : 465)
Query Neighborhood Hits	185	Target Neighborhood Hits	872	Shared Neighborhood Hits	42
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

NEK8_MOUSE
θ value	θ > 10 (rank : 669)	NC score	0.075493 (rank : 467)
Query Neighborhood Hits	185	Target Neighborhood Hits	872	Shared Neighborhood Hits	42
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

NEK9_HUMAN
θ value	θ > 10 (rank : 670)	NC score	0.076403 (rank : 447)
Query Neighborhood Hits	185	Target Neighborhood Hits	900	Shared Neighborhood Hits	42
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

NEK9_MOUSE
θ value	θ > 10 (rank : 671)	NC score	0.077369 (rank : 432)
Query Neighborhood Hits	185	Target Neighborhood Hits	890	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

NIM1_HUMAN
θ value	θ > 10 (rank : 672)	NC score	0.088497 (rank : 283)
Query Neighborhood Hits	185	Target Neighborhood Hits	850	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

NIM1_MOUSE
θ value	θ > 10 (rank : 673)	NC score	0.088413 (rank : 285)
Query Neighborhood Hits	185	Target Neighborhood Hits	850	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

NLK_HUMAN
θ value	θ > 10 (rank : 674)	NC score	0.059698 (rank : 762)
Query Neighborhood Hits	185	Target Neighborhood Hits	840	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

NLK_MOUSE
θ value	θ > 10 (rank : 675)	NC score	0.059834 (rank : 759)
Query Neighborhood Hits	185	Target Neighborhood Hits	839	Shared Neighborhood Hits	41
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

NRK_HUMAN
θ value	θ > 10 (rank : 676)	NC score	0.069624 (rank : 588)
Query Neighborhood Hits	185	Target Neighborhood Hits	931	Shared Neighborhood Hits	44
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

NRK_MOUSE
θ value	θ > 10 (rank : 677)	NC score	0.070681 (rank : 564)
Query Neighborhood Hits	185	Target Neighborhood Hits	899	Shared Neighborhood Hits	45
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

NUAK1_HUMAN
θ value	θ > 10 (rank : 678)	NC score	0.085934 (rank : 320)
Query Neighborhood Hits	185	Target Neighborhood Hits	874	Shared Neighborhood Hits	42
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

NUAK1_MOUSE
θ value	θ > 10 (rank : 679)	NC score	0.085947 (rank : 319)
Query Neighborhood Hits	185	Target Neighborhood Hits	881	Shared Neighborhood Hits	42
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

NUAK2_HUMAN
θ value	θ > 10 (rank : 680)	NC score	0.087706 (rank : 297)
Query Neighborhood Hits	185	Target Neighborhood Hits	874	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

NUAK2_MOUSE
θ value	θ > 10 (rank : 681)	NC score	0.089740 (rank : 259)
Query Neighborhood Hits	185	Target Neighborhood Hits	878	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

OBSCN_HUMAN
θ value	θ > 10 (rank : 682)	NC score	0.074172 (rank : 494)
Query Neighborhood Hits	185	Target Neighborhood Hits	1931	Shared Neighborhood Hits	62
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

OPHN1_HUMAN
θ value	θ > 10 (rank : 683)	NC score	0.058470 (rank : 783)
Query Neighborhood Hits	185	Target Neighborhood Hits	161	Shared Neighborhood Hits	16
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

OPHN1_MOUSE
θ value	θ > 10 (rank : 684)	NC score	0.058299 (rank : 791)
Query Neighborhood Hits	185	Target Neighborhood Hits	174	Shared Neighborhood Hits	17
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

OXSR1_HUMAN
θ value	θ > 10 (rank : 685)	NC score	0.071364 (rank : 554)
Query Neighborhood Hits	185	Target Neighborhood Hits	874	Shared Neighborhood Hits	40
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

OXSR1_MOUSE
θ value	θ > 10 (rank : 686)	NC score	0.071898 (rank : 539)
Query Neighborhood Hits	185	Target Neighborhood Hits	865	Shared Neighborhood Hits	41
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

PAK1_HUMAN
θ value	θ > 10 (rank : 687)	NC score	0.075768 (rank : 462)
Query Neighborhood Hits	185	Target Neighborhood Hits	873	Shared Neighborhood Hits	40
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

PAK1_MOUSE
θ value	θ > 10 (rank : 688)	NC score	0.075879 (rank : 460)
Query Neighborhood Hits	185	Target Neighborhood Hits	878	Shared Neighborhood Hits	40
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

PAK2_HUMAN
θ value	θ > 10 (rank : 689)	NC score	0.076409 (rank : 446)
Query Neighborhood Hits	185	Target Neighborhood Hits	862	Shared Neighborhood Hits	41
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

PAK2_MOUSE
θ value	θ > 10 (rank : 690)	NC score	0.076303 (rank : 450)
Query Neighborhood Hits	185	Target Neighborhood Hits	858	Shared Neighborhood Hits	40
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

PAK3_HUMAN
θ value	θ > 10 (rank : 691)	NC score	0.076077 (rank : 455)
Query Neighborhood Hits	185	Target Neighborhood Hits	887	Shared Neighborhood Hits	43
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PAK3_MOUSE
θ value	θ > 10 (rank : 692)	NC score	0.075979 (rank : 456)
Query Neighborhood Hits	185	Target Neighborhood Hits	874	Shared Neighborhood Hits	41
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

PAK4_HUMAN
θ value	θ > 10 (rank : 693)	NC score	0.079193 (rank : 405)
Query Neighborhood Hits	185	Target Neighborhood Hits	924	Shared Neighborhood Hits	42
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PAK4_MOUSE
θ value	θ > 10 (rank : 694)	NC score	0.079772 (rank : 401)
Query Neighborhood Hits	185	Target Neighborhood Hits	1098	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PAK6_HUMAN
θ value	θ > 10 (rank : 695)	NC score	0.077966 (rank : 425)
Query Neighborhood Hits	185	Target Neighborhood Hits	915	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

PAK7_HUMAN
θ value	θ > 10 (rank : 696)	NC score	0.079181 (rank : 406)
Query Neighborhood Hits	185	Target Neighborhood Hits	875	Shared Neighborhood Hits	40
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

PAK7_MOUSE
θ value	θ > 10 (rank : 697)	NC score	0.078709 (rank : 414)
Query Neighborhood Hits	185	Target Neighborhood Hits	875	Shared Neighborhood Hits	41
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

PAR3L_HUMAN
θ value	θ > 10 (rank : 698)	NC score	0.108355 (rank : 175)
Query Neighborhood Hits	185	Target Neighborhood Hits	297	Shared Neighborhood Hits	41
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

PASK_HUMAN
θ value	θ > 10 (rank : 699)	NC score	0.084959 (rank : 337)
Query Neighborhood Hits	185	Target Neighborhood Hits	857	Shared Neighborhood Hits	41
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

PASK_MOUSE
θ value	θ > 10 (rank : 700)	NC score	0.085613 (rank : 324)
Query Neighborhood Hits	185	Target Neighborhood Hits	867	Shared Neighborhood Hits	40
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

PCLO_HUMAN
θ value	θ > 10 (rank : 701)	NC score	0.065207 (rank : 668)
Query Neighborhood Hits	185	Target Neighborhood Hits	2046	Shared Neighborhood Hits	79
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PCLO_MOUSE
θ value	θ > 10 (rank : 702)	NC score	0.075044 (rank : 479)
Query Neighborhood Hits	185	Target Neighborhood Hits	2275	Shared Neighborhood Hits	83
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PCTK1_HUMAN
θ value	θ > 10 (rank : 703)	NC score	0.067615 (rank : 627)
Query Neighborhood Hits	185	Target Neighborhood Hits	832	Shared Neighborhood Hits	40
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

PCTK1_MOUSE
θ value	θ > 10 (rank : 704)	NC score	0.067740 (rank : 623)
Query Neighborhood Hits	185	Target Neighborhood Hits	832	Shared Neighborhood Hits	40
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

PCTK2_HUMAN
θ value	θ > 10 (rank : 705)	NC score	0.067762 (rank : 622)
Query Neighborhood Hits	185	Target Neighborhood Hits	837	Shared Neighborhood Hits	40
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK2_MOUSE
θ value	θ > 10 (rank : 706)	NC score	0.067831 (rank : 620)
Query Neighborhood Hits	185	Target Neighborhood Hits	836	Shared Neighborhood Hits	40
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK3_HUMAN
θ value	θ > 10 (rank : 707)	NC score	0.068032 (rank : 616)
Query Neighborhood Hits	185	Target Neighborhood Hits	827	Shared Neighborhood Hits	40
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

PCTK3_MOUSE
θ value	θ > 10 (rank : 708)	NC score	0.068298 (rank : 610)
Query Neighborhood Hits	185	Target Neighborhood Hits	834	Shared Neighborhood Hits	41
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

PDK1L_HUMAN
θ value	θ > 10 (rank : 709)	NC score	0.083372 (rank : 360)
Query Neighborhood Hits	185	Target Neighborhood Hits	821	Shared Neighborhood Hits	40
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PDK1L_MOUSE
θ value	θ > 10 (rank : 710)	NC score	0.083101 (rank : 368)
Query Neighborhood Hits	185	Target Neighborhood Hits	821	Shared Neighborhood Hits	40
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PDLI2_HUMAN
θ value	θ > 10 (rank : 711)	NC score	0.051110 (rank : 881)
Query Neighborhood Hits	185	Target Neighborhood Hits	245	Shared Neighborhood Hits	38
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

PDPK1_HUMAN
θ value	θ > 10 (rank : 712)	NC score	0.102735 (rank : 203)
Query Neighborhood Hits	185	Target Neighborhood Hits	851	Shared Neighborhood Hits	41
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

PDPK1_MOUSE
θ value	θ > 10 (rank : 713)	NC score	0.102881 (rank : 201)
Query Neighborhood Hits	185	Target Neighborhood Hits	852	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

PDZ11_HUMAN
θ value	θ > 10 (rank : 714)	NC score	0.088554 (rank : 282)
Query Neighborhood Hits	185	Target Neighborhood Hits	160	Shared Neighborhood Hits	34
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZ11_MOUSE
θ value	θ > 10 (rank : 715)	NC score	0.087768 (rank : 296)
Query Neighborhood Hits	185	Target Neighborhood Hits	154	Shared Neighborhood Hits	32
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZD2_HUMAN
θ value	θ > 10 (rank : 716)	NC score	0.093845 (rank : 230)
Query Neighborhood Hits	185	Target Neighborhood Hits	772	Shared Neighborhood Hits	53
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

PDZD7_HUMAN
θ value	θ > 10 (rank : 717)	NC score	0.115992 (rank : 126)
Query Neighborhood Hits	185	Target Neighborhood Hits	181	Shared Neighborhood Hits	43
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

PDZK4_MOUSE
θ value	θ > 10 (rank : 718)	NC score	0.082442 (rank : 383)
Query Neighborhood Hits	185	Target Neighborhood Hits	165	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PFTK1_HUMAN
θ value	θ > 10 (rank : 719)	NC score	0.071331 (rank : 555)
Query Neighborhood Hits	185	Target Neighborhood Hits	834	Shared Neighborhood Hits	41
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PFTK1_MOUSE
θ value	θ > 10 (rank : 720)	NC score	0.071949 (rank : 537)
Query Neighborhood Hits	185	Target Neighborhood Hits	835	Shared Neighborhood Hits	42
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PHKG1_HUMAN
θ value	θ > 10 (rank : 721)	NC score	0.083382 (rank : 359)
Query Neighborhood Hits	185	Target Neighborhood Hits	838	Shared Neighborhood Hits	40
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

PHKG1_MOUSE
θ value	θ > 10 (rank : 722)	NC score	0.084490 (rank : 345)
Query Neighborhood Hits	185	Target Neighborhood Hits	840	Shared Neighborhood Hits	40
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

PHKG2_HUMAN
θ value	θ > 10 (rank : 723)	NC score	0.082640 (rank : 379)
Query Neighborhood Hits	185	Target Neighborhood Hits	839	Shared Neighborhood Hits	40
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

PHKG2_MOUSE
θ value	θ > 10 (rank : 724)	NC score	0.082736 (rank : 378)
Query Neighborhood Hits	185	Target Neighborhood Hits	841	Shared Neighborhood Hits	40
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

PIM1_HUMAN
θ value	θ > 10 (rank : 725)	NC score	0.084270 (rank : 349)
Query Neighborhood Hits	185	Target Neighborhood Hits	797	Shared Neighborhood Hits	40
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

PIM1_MOUSE
θ value	θ > 10 (rank : 726)	NC score	0.086331 (rank : 313)
Query Neighborhood Hits	185	Target Neighborhood Hits	787	Shared Neighborhood Hits	40
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

PIM2_HUMAN
θ value	θ > 10 (rank : 727)	NC score	0.090078 (rank : 257)
Query Neighborhood Hits	185	Target Neighborhood Hits	808	Shared Neighborhood Hits	40
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

PIM2_MOUSE
θ value	θ > 10 (rank : 728)	NC score	0.091299 (rank : 244)
Query Neighborhood Hits	185	Target Neighborhood Hits	809	Shared Neighborhood Hits	40
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

PIM3_HUMAN
θ value	θ > 10 (rank : 729)	NC score	0.088585 (rank : 281)
Query Neighborhood Hits	185	Target Neighborhood Hits	789	Shared Neighborhood Hits	40
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

PIM3_MOUSE
θ value	θ > 10 (rank : 730)	NC score	0.089609 (rank : 261)
Query Neighborhood Hits	185	Target Neighborhood Hits	783	Shared Neighborhood Hits	40
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

PINK1_HUMAN
θ value	θ > 10 (rank : 731)	NC score	0.076452 (rank : 444)
Query Neighborhood Hits	185	Target Neighborhood Hits	741	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

PINK1_MOUSE
θ value	θ > 10 (rank : 732)	NC score	0.084509 (rank : 343)
Query Neighborhood Hits	185	Target Neighborhood Hits	726	Shared Neighborhood Hits	40
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

PKN1_HUMAN
θ value	θ > 10 (rank : 733)	NC score	0.122197 (rank : 92)
Query Neighborhood Hits	185	Target Neighborhood Hits	886	Shared Neighborhood Hits	41
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

PKN1_MOUSE
θ value	θ > 10 (rank : 734)	NC score	0.122027 (rank : 94)
Query Neighborhood Hits	185	Target Neighborhood Hits	888	Shared Neighborhood Hits	40
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

PKN2_HUMAN
θ value	θ > 10 (rank : 735)	NC score	0.121122 (rank : 96)
Query Neighborhood Hits	185	Target Neighborhood Hits	892	Shared Neighborhood Hits	40
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN2_MOUSE
θ value	θ > 10 (rank : 736)	NC score	0.120993 (rank : 98)
Query Neighborhood Hits	185	Target Neighborhood Hits	899	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN3_HUMAN
θ value	θ > 10 (rank : 737)	NC score	0.122167 (rank : 93)
Query Neighborhood Hits	185	Target Neighborhood Hits	893	Shared Neighborhood Hits	43
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PKN3_MOUSE
θ value	θ > 10 (rank : 738)	NC score	0.120426 (rank : 100)
Query Neighborhood Hits	185	Target Neighborhood Hits	1009	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PLK1_HUMAN
θ value	θ > 10 (rank : 739)	NC score	0.087031 (rank : 304)
Query Neighborhood Hits	185	Target Neighborhood Hits	849	Shared Neighborhood Hits	40
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

PLK1_MOUSE
θ value	θ > 10 (rank : 740)	NC score	0.087333 (rank : 301)
Query Neighborhood Hits	185	Target Neighborhood Hits	849	Shared Neighborhood Hits	41
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

PLK2_HUMAN
θ value	θ > 10 (rank : 741)	NC score	0.084369 (rank : 348)
Query Neighborhood Hits	185	Target Neighborhood Hits	854	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK2_MOUSE
θ value	θ > 10 (rank : 742)	NC score	0.084027 (rank : 350)
Query Neighborhood Hits	185	Target Neighborhood Hits	849	Shared Neighborhood Hits	40
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK3_HUMAN
θ value	θ > 10 (rank : 743)	NC score	0.082753 (rank : 376)
Query Neighborhood Hits	185	Target Neighborhood Hits	865	Shared Neighborhood Hits	40
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

PLK3_MOUSE
θ value	θ > 10 (rank : 744)	NC score	0.082072 (rank : 385)
Query Neighborhood Hits	185	Target Neighborhood Hits	863	Shared Neighborhood Hits	40
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

PLK4_HUMAN
θ value	θ > 10 (rank : 745)	NC score	0.086527 (rank : 306)
Query Neighborhood Hits	185	Target Neighborhood Hits	884	Shared Neighborhood Hits	40
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PLK4_MOUSE
θ value	θ > 10 (rank : 746)	NC score	0.086525 (rank : 307)
Query Neighborhood Hits	185	Target Neighborhood Hits	879	Shared Neighborhood Hits	40
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PMYT1_HUMAN
θ value	θ > 10 (rank : 747)	NC score	0.083685 (rank : 355)
Query Neighborhood Hits	185	Target Neighborhood Hits	814	Shared Neighborhood Hits	41
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

PMYT1_MOUSE
θ value	θ > 10 (rank : 748)	NC score	0.082592 (rank : 380)
Query Neighborhood Hits	185	Target Neighborhood Hits	910	Shared Neighborhood Hits	41
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

PRKX_HUMAN
θ value	θ > 10 (rank : 749)	NC score	0.108892 (rank : 171)
Query Neighborhood Hits	185	Target Neighborhood Hits	847	Shared Neighborhood Hits	40
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

PRKX_MOUSE
θ value	θ > 10 (rank : 750)	NC score	0.108866 (rank : 172)
Query Neighborhood Hits	185	Target Neighborhood Hits	846	Shared Neighborhood Hits	40
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

PRKY_HUMAN
θ value	θ > 10 (rank : 751)	NC score	0.103865 (rank : 193)
Query Neighborhood Hits	185	Target Neighborhood Hits	844	Shared Neighborhood Hits	40
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

PRP4B_HUMAN
θ value	θ > 10 (rank : 752)	NC score	0.071538 (rank : 550)
Query Neighborhood Hits	185	Target Neighborhood Hits	1030	Shared Neighborhood Hits	51
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

PRP4B_MOUSE
θ value	θ > 10 (rank : 753)	NC score	0.071897 (rank : 540)
Query Neighborhood Hits	185	Target Neighborhood Hits	1040	Shared Neighborhood Hits	49
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

PSCBP_HUMAN
θ value	θ > 10 (rank : 754)	NC score	0.073913 (rank : 496)
Query Neighborhood Hits	185	Target Neighborhood Hits	123	Shared Neighborhood Hits	33
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

PSCBP_MOUSE
θ value	θ > 10 (rank : 755)	NC score	0.079869 (rank : 400)
Query Neighborhood Hits	185	Target Neighborhood Hits	118	Shared Neighborhood Hits	33
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

PTK6_HUMAN
θ value	θ > 10 (rank : 756)	NC score	0.054740 (rank : 840)
Query Neighborhood Hits	185	Target Neighborhood Hits	1020	Shared Neighborhood Hits	54
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

PTK6_MOUSE
θ value	θ > 10 (rank : 757)	NC score	0.057251 (rank : 808)
Query Neighborhood Hits	185	Target Neighborhood Hits	1026	Shared Neighborhood Hits	54
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

PTN13_HUMAN
θ value	θ > 10 (rank : 758)	NC score	0.056441 (rank : 817)
Query Neighborhood Hits	185	Target Neighborhood Hits	471	Shared Neighborhood Hits	43
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

PTN13_MOUSE
θ value	θ > 10 (rank : 759)	NC score	0.056390 (rank : 820)
Query Neighborhood Hits	185	Target Neighborhood Hits	426	Shared Neighborhood Hits	45
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

PXK_HUMAN
θ value	θ > 10 (rank : 760)	NC score	0.073717 (rank : 500)
Query Neighborhood Hits	185	Target Neighborhood Hits	216	Shared Neighborhood Hits	20
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

PXK_MOUSE
θ value	θ > 10 (rank : 761)	NC score	0.070874 (rank : 561)
Query Neighborhood Hits	185	Target Neighborhood Hits	320	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

PZRN4_HUMAN
θ value	θ > 10 (rank : 762)	NC score	0.093101 (rank : 234)
Query Neighborhood Hits	185	Target Neighborhood Hits	438	Shared Neighborhood Hits	45
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

RAF1_HUMAN
θ value	θ > 10 (rank : 763)	NC score	0.078269 (rank : 421)
Query Neighborhood Hits	185	Target Neighborhood Hits	886	Shared Neighborhood Hits	63
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAF1_MOUSE
θ value	θ > 10 (rank : 764)	NC score	0.078608 (rank : 416)
Query Neighborhood Hits	185	Target Neighborhood Hits	886	Shared Neighborhood Hits	63
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RASF3_HUMAN
θ value	θ > 10 (rank : 765)	NC score	0.069670 (rank : 585)
Query Neighborhood Hits	185	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	Q86WH2, Q86WH1	Gene names	RASSF3
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 3.

RASF3_MOUSE
θ value	θ > 10 (rank : 766)	NC score	0.069723 (rank : 583)
Query Neighborhood Hits	185	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q99P51, Q3TJ17	Gene names	Rassf3
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 3.

RASL1_HUMAN
θ value	θ > 10 (rank : 767)	NC score	0.058083 (rank : 792)
Query Neighborhood Hits	185	Target Neighborhood Hits	142	Shared Neighborhood Hits	14
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL1_MOUSE
θ value	θ > 10 (rank : 768)	NC score	0.060383 (rank : 744)
Query Neighborhood Hits	185	Target Neighborhood Hits	148	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL2_HUMAN
θ value	θ > 10 (rank : 769)	NC score	0.054444 (rank : 845)
Query Neighborhood Hits	185	Target Neighborhood Hits	161	Shared Neighborhood Hits	14
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

RBP1_HUMAN
θ value	θ > 10 (rank : 770)	NC score	0.059904 (rank : 756)
Query Neighborhood Hits	185	Target Neighborhood Hits	521	Shared Neighborhood Hits	33
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RBP1_MOUSE
θ value	θ > 10 (rank : 771)	NC score	0.060299 (rank : 746)
Query Neighborhood Hits	185	Target Neighborhood Hits	493	Shared Neighborhood Hits	30
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RGS12_HUMAN
θ value	θ > 10 (rank : 772)	NC score	0.064261 (rank : 684)
Query Neighborhood Hits	185	Target Neighborhood Hits	333	Shared Neighborhood Hits	46
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

RHG04_HUMAN
θ value	θ > 10 (rank : 773)	NC score	0.050970 (rank : 884)
Query Neighborhood Hits	185	Target Neighborhood Hits	307	Shared Neighborhood Hits	24
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RHG05_HUMAN
θ value	θ > 10 (rank : 774)	NC score	0.054480 (rank : 844)
Query Neighborhood Hits	185	Target Neighborhood Hits	158	Shared Neighborhood Hits	12
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG05_MOUSE
θ value	θ > 10 (rank : 775)	NC score	0.053523 (rank : 851)
Query Neighborhood Hits	185	Target Neighborhood Hits	165	Shared Neighborhood Hits	12
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG06_HUMAN
θ value	θ > 10 (rank : 776)	NC score	0.052734 (rank : 856)
Query Neighborhood Hits	185	Target Neighborhood Hits	114	Shared Neighborhood Hits	12
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG06_MOUSE
θ value	θ > 10 (rank : 777)	NC score	0.051594 (rank : 878)
Query Neighborhood Hits	185	Target Neighborhood Hits	105	Shared Neighborhood Hits	10
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG09_HUMAN
θ value	θ > 10 (rank : 778)	NC score	0.061260 (rank : 725)
Query Neighborhood Hits	185	Target Neighborhood Hits	186	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

RHG12_HUMAN
θ value	θ > 10 (rank : 779)	NC score	0.056487 (rank : 815)
Query Neighborhood Hits	185	Target Neighborhood Hits	190	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	θ > 10 (rank : 780)	NC score	0.057139 (rank : 809)
Query Neighborhood Hits	185	Target Neighborhood Hits	204	Shared Neighborhood Hits	13
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG25_HUMAN
θ value	θ > 10 (rank : 781)	NC score	0.056459 (rank : 816)
Query Neighborhood Hits	185	Target Neighborhood Hits	550	Shared Neighborhood Hits	29
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_MOUSE
θ value	θ > 10 (rank : 782)	NC score	0.059621 (rank : 764)
Query Neighborhood Hits	185	Target Neighborhood Hits	492	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG26_HUMAN
θ value	θ > 10 (rank : 783)	NC score	0.059442 (rank : 769)
Query Neighborhood Hits	185	Target Neighborhood Hits	281	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RHPN1_HUMAN
θ value	θ > 10 (rank : 784)	NC score	0.073579 (rank : 503)
Query Neighborhood Hits	185	Target Neighborhood Hits	158	Shared Neighborhood Hits	40
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

RHPN1_MOUSE
θ value	θ > 10 (rank : 785)	NC score	0.076098 (rank : 453)
Query Neighborhood Hits	185	Target Neighborhood Hits	154	Shared Neighborhood Hits	39
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

RIMS1_HUMAN
θ value	θ > 10 (rank : 786)	NC score	0.080970 (rank : 395)
Query Neighborhood Hits	185	Target Neighborhood Hits	437	Shared Neighborhood Hits	51
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

RIMS2_HUMAN
θ value	θ > 10 (rank : 787)	NC score	0.063217 (rank : 694)
Query Neighborhood Hits	185	Target Neighborhood Hits	342	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	θ > 10 (rank : 788)	NC score	0.062924 (rank : 699)
Query Neighborhood Hits	185	Target Neighborhood Hits	376	Shared Neighborhood Hits	38
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RIPK1_HUMAN
θ value	θ > 10 (rank : 789)	NC score	0.064486 (rank : 681)
Query Neighborhood Hits	185	Target Neighborhood Hits	891	Shared Neighborhood Hits	41
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK1_MOUSE
θ value	θ > 10 (rank : 790)	NC score	0.063837 (rank : 687)
Query Neighborhood Hits	185	Target Neighborhood Hits	874	Shared Neighborhood Hits	40
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK2_HUMAN
θ value	θ > 10 (rank : 791)	NC score	0.066613 (rank : 641)
Query Neighborhood Hits	185	Target Neighborhood Hits	774	Shared Neighborhood Hits	40
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RIPK2_MOUSE
θ value	θ > 10 (rank : 792)	NC score	0.069651 (rank : 587)
Query Neighborhood Hits	185	Target Neighborhood Hits	776	Shared Neighborhood Hits	40
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK3_HUMAN
θ value	θ > 10 (rank : 793)	NC score	0.072579 (rank : 523)
Query Neighborhood Hits	185	Target Neighborhood Hits	828	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

RIPK3_MOUSE
θ value	θ > 10 (rank : 794)	NC score	0.075722 (rank : 464)
Query Neighborhood Hits	185	Target Neighborhood Hits	867	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

RIPK4_HUMAN
θ value	θ > 10 (rank : 795)	NC score	0.050221 (rank : 900)
Query Neighborhood Hits	185	Target Neighborhood Hits	1094	Shared Neighborhood Hits	41
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

RIPK5_HUMAN
θ value	θ > 10 (rank : 796)	NC score	0.083027 (rank : 370)
Query Neighborhood Hits	185	Target Neighborhood Hits	864	Shared Neighborhood Hits	40
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK5_MOUSE
θ value	θ > 10 (rank : 797)	NC score	0.083191 (rank : 365)
Query Neighborhood Hits	185	Target Neighborhood Hits	874	Shared Neighborhood Hits	40
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

RK_HUMAN
θ value	θ > 10 (rank : 798)	NC score	0.113168 (rank : 139)
Query Neighborhood Hits	185	Target Neighborhood Hits	835	Shared Neighborhood Hits	40
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

RK_MOUSE
θ value	θ > 10 (rank : 799)	NC score	0.109522 (rank : 166)
Query Neighborhood Hits	185	Target Neighborhood Hits	829	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

ROCK1_MOUSE
θ value	θ > 10 (rank : 800)	NC score	0.110802 (rank : 159)
Query Neighborhood Hits	185	Target Neighborhood Hits	2126	Shared Neighborhood Hits	71
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

RP3A_HUMAN
θ value	θ > 10 (rank : 801)	NC score	0.050086 (rank : 902)
Query Neighborhood Hits	185	Target Neighborhood Hits	305	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

RPGF2_HUMAN
θ value	θ > 10 (rank : 802)	NC score	0.062007 (rank : 715)
Query Neighborhood Hits	185	Target Neighborhood Hits	242	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF6_HUMAN
θ value	θ > 10 (rank : 803)	NC score	0.066641 (rank : 640)
Query Neighborhood Hits	185	Target Neighborhood Hits	266	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

RPKL1_HUMAN
θ value	θ > 10 (rank : 804)	NC score	0.130648 (rank : 76)
Query Neighborhood Hits	185	Target Neighborhood Hits	708	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

RPKL1_MOUSE
θ value	θ > 10 (rank : 805)	NC score	0.130614 (rank : 77)
Query Neighborhood Hits	185	Target Neighborhood Hits	704	Shared Neighborhood Hits	41
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

SBK1_HUMAN
θ value	θ > 10 (rank : 806)	NC score	0.091359 (rank : 242)
Query Neighborhood Hits	185	Target Neighborhood Hits	828	Shared Neighborhood Hits	40
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

SBK1_MOUSE
θ value	θ > 10 (rank : 807)	NC score	0.090757 (rank : 248)
Query Neighborhood Hits	185	Target Neighborhood Hits	824	Shared Neighborhood Hits	41
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

SCYL2_HUMAN
θ value	θ > 10 (rank : 808)	NC score	0.075935 (rank : 458)
Query Neighborhood Hits	185	Target Neighborhood Hits	632	Shared Neighborhood Hits	41
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SCYL2_MOUSE
θ value	θ > 10 (rank : 809)	NC score	0.077242 (rank : 436)
Query Neighborhood Hits	185	Target Neighborhood Hits	603	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SGK1_HUMAN
θ value	θ > 10 (rank : 810)	NC score	0.117218 (rank : 121)
Query Neighborhood Hits	185	Target Neighborhood Hits	848	Shared Neighborhood Hits	40
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

SGK1_MOUSE
θ value	θ > 10 (rank : 811)	NC score	0.117405 (rank : 120)
Query Neighborhood Hits	185	Target Neighborhood Hits	848	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

SGK2_HUMAN
θ value	θ > 10 (rank : 812)	NC score	0.118481 (rank : 108)
Query Neighborhood Hits	185	Target Neighborhood Hits	840	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

SGK2_MOUSE
θ value	θ > 10 (rank : 813)	NC score	0.117536 (rank : 117)
Query Neighborhood Hits	185	Target Neighborhood Hits	833	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

SGK3_HUMAN
θ value	θ > 10 (rank : 814)	NC score	0.117798 (rank : 114)
Query Neighborhood Hits	185	Target Neighborhood Hits	877	Shared Neighborhood Hits	40
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

SGK3_MOUSE
θ value	θ > 10 (rank : 815)	NC score	0.117521 (rank : 118)
Query Neighborhood Hits	185	Target Neighborhood Hits	882	Shared Neighborhood Hits	40
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

SHAN2_HUMAN
θ value	θ > 10 (rank : 816)	NC score	0.074501 (rank : 490)
Query Neighborhood Hits	185	Target Neighborhood Hits	346	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

SHAN2_MOUSE
θ value	θ > 10 (rank : 817)	NC score	0.073047 (rank : 518)
Query Neighborhood Hits	185	Target Neighborhood Hits	446	Shared Neighborhood Hits	55
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SLK_HUMAN
θ value	θ > 10 (rank : 818)	NC score	0.073852 (rank : 497)
Query Neighborhood Hits	185	Target Neighborhood Hits	1775	Shared Neighborhood Hits	64
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

SLK_MOUSE
θ value	θ > 10 (rank : 819)	NC score	0.074773 (rank : 484)
Query Neighborhood Hits	185	Target Neighborhood Hits	1798	Shared Neighborhood Hits	71
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

SN1L1_HUMAN
θ value	θ > 10 (rank : 820)	NC score	0.084555 (rank : 342)
Query Neighborhood Hits	185	Target Neighborhood Hits	911	Shared Neighborhood Hits	43
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

SN1L1_MOUSE
θ value	θ > 10 (rank : 821)	NC score	0.082802 (rank : 373)
Query Neighborhood Hits	185	Target Neighborhood Hits	895	Shared Neighborhood Hits	40
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

SN1L2_HUMAN
θ value	θ > 10 (rank : 822)	NC score	0.085072 (rank : 333)
Query Neighborhood Hits	185	Target Neighborhood Hits	964	Shared Neighborhood Hits	52
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

SN1L2_MOUSE
θ value	θ > 10 (rank : 823)	NC score	0.085426 (rank : 327)
Query Neighborhood Hits	185	Target Neighborhood Hits	944	Shared Neighborhood Hits	54
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

SNRK_HUMAN
θ value	θ > 10 (rank : 824)	NC score	0.083145 (rank : 367)
Query Neighborhood Hits	185	Target Neighborhood Hits	855	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

SNRK_MOUSE
θ value	θ > 10 (rank : 825)	NC score	0.082039 (rank : 387)
Query Neighborhood Hits	185	Target Neighborhood Hits	849	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

SNTA1_HUMAN
θ value	θ > 10 (rank : 826)	NC score	0.062528 (rank : 703)
Query Neighborhood Hits	185	Target Neighborhood Hits	186	Shared Neighborhood Hits	39
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

SNTA1_MOUSE
θ value	θ > 10 (rank : 827)	NC score	0.063380 (rank : 691)
Query Neighborhood Hits	185	Target Neighborhood Hits	170	Shared Neighborhood Hits	38
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

SNTB1_HUMAN
θ value	θ > 10 (rank : 828)	NC score	0.060145 (rank : 752)
Query Neighborhood Hits	185	Target Neighborhood Hits	157	Shared Neighborhood Hits	33
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

SNTB1_MOUSE
θ value	θ > 10 (rank : 829)	NC score	0.060904 (rank : 735)
Query Neighborhood Hits	185	Target Neighborhood Hits	160	Shared Neighborhood Hits	33
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

SNTB2_HUMAN
θ value	θ > 10 (rank : 830)	NC score	0.070099 (rank : 580)
Query Neighborhood Hits	185	Target Neighborhood Hits	180	Shared Neighborhood Hits	37
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

SNTB2_MOUSE
θ value	θ > 10 (rank : 831)	NC score	0.069670 (rank : 586)
Query Neighborhood Hits	185	Target Neighborhood Hits	181	Shared Neighborhood Hits	37
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

SNTG1_HUMAN
θ value	θ > 10 (rank : 832)	NC score	0.067026 (rank : 635)
Query Neighborhood Hits	185	Target Neighborhood Hits	181	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTG1_MOUSE
θ value	θ > 10 (rank : 833)	NC score	0.066556 (rank : 642)
Query Neighborhood Hits	185	Target Neighborhood Hits	179	Shared Neighborhood Hits	40
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTG2_HUMAN
θ value	θ > 10 (rank : 834)	NC score	0.073063 (rank : 516)
Query Neighborhood Hits	185	Target Neighborhood Hits	191	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SNTG2_MOUSE
θ value	θ > 10 (rank : 835)	NC score	0.065985 (rank : 651)
Query Neighborhood Hits	185	Target Neighborhood Hits	176	Shared Neighborhood Hits	41
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SPEG_HUMAN
θ value	θ > 10 (rank : 836)	NC score	0.076419 (rank : 445)
Query Neighborhood Hits	185	Target Neighborhood Hits	1762	Shared Neighborhood Hits	65
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SPEG_MOUSE
θ value	θ > 10 (rank : 837)	NC score	0.074187 (rank : 493)
Query Neighborhood Hits	185	Target Neighborhood Hits	1959	Shared Neighborhood Hits	68
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SRC_HUMAN
θ value	θ > 10 (rank : 838)	NC score	0.050807 (rank : 891)
Query Neighborhood Hits	185	Target Neighborhood Hits	1058	Shared Neighborhood Hits	56
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRGP1_HUMAN
θ value	θ > 10 (rank : 839)	NC score	0.051040 (rank : 883)
Query Neighborhood Hits	185	Target Neighborhood Hits	390	Shared Neighborhood Hits	31
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRMS_MOUSE
θ value	θ > 10 (rank : 840)	NC score	0.050473 (rank : 895)
Query Neighborhood Hits	185	Target Neighborhood Hits	964	Shared Neighborhood Hits	45
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

ST17A_HUMAN
θ value	θ > 10 (rank : 841)	NC score	0.090715 (rank : 250)
Query Neighborhood Hits	185	Target Neighborhood Hits	843	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

ST17B_HUMAN
θ value	θ > 10 (rank : 842)	NC score	0.089423 (rank : 266)
Query Neighborhood Hits	185	Target Neighborhood Hits	833	Shared Neighborhood Hits	40
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

ST17B_MOUSE
θ value	θ > 10 (rank : 843)	NC score	0.087955 (rank : 293)
Query Neighborhood Hits	185	Target Neighborhood Hits	838	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

ST32A_HUMAN
θ value	θ > 10 (rank : 844)	NC score	0.104575 (rank : 190)
Query Neighborhood Hits	185	Target Neighborhood Hits	834	Shared Neighborhood Hits	40
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

ST32A_MOUSE
θ value	θ > 10 (rank : 845)	NC score	0.103537 (rank : 196)
Query Neighborhood Hits	185	Target Neighborhood Hits	833	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

ST32B_HUMAN
θ value	θ > 10 (rank : 846)	NC score	0.105659 (rank : 184)
Query Neighborhood Hits	185	Target Neighborhood Hits	830	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

ST32B_MOUSE
θ value	θ > 10 (rank : 847)	NC score	0.104869 (rank : 188)
Query Neighborhood Hits	185	Target Neighborhood Hits	828	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

ST32C_HUMAN
θ value	θ > 10 (rank : 848)	NC score	0.106428 (rank : 181)
Query Neighborhood Hits	185	Target Neighborhood Hits	832	Shared Neighborhood Hits	42
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

ST32C_MOUSE
θ value	θ > 10 (rank : 849)	NC score	0.106155 (rank : 182)
Query Neighborhood Hits	185	Target Neighborhood Hits	824	Shared Neighborhood Hits	41
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

ST38L_HUMAN
θ value	θ > 10 (rank : 850)	NC score	0.116157 (rank : 125)
Query Neighborhood Hits	185	Target Neighborhood Hits	824	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

ST38L_MOUSE
θ value	θ > 10 (rank : 851)	NC score	0.117180 (rank : 122)
Query Neighborhood Hits	185	Target Neighborhood Hits	821	Shared Neighborhood Hits	40
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

STK10_HUMAN
θ value	θ > 10 (rank : 852)	NC score	0.074033 (rank : 495)
Query Neighborhood Hits	185	Target Neighborhood Hits	1921	Shared Neighborhood Hits	63
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

STK10_MOUSE
θ value	θ > 10 (rank : 853)	NC score	0.074272 (rank : 492)
Query Neighborhood Hits	185	Target Neighborhood Hits	2132	Shared Neighborhood Hits	69
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

STK11_HUMAN
θ value	θ > 10 (rank : 854)	NC score	0.083326 (rank : 362)
Query Neighborhood Hits	185	Target Neighborhood Hits	831	Shared Neighborhood Hits	40
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

STK16_HUMAN
θ value	θ > 10 (rank : 855)	NC score	0.065339 (rank : 663)
Query Neighborhood Hits	185	Target Neighborhood Hits	824	Shared Neighborhood Hits	40
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

STK16_MOUSE
θ value	θ > 10 (rank : 856)	NC score	0.058708 (rank : 776)
Query Neighborhood Hits	185	Target Neighborhood Hits	824	Shared Neighborhood Hits	40
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

STK24_HUMAN
θ value	θ > 10 (rank : 857)	NC score	0.071718 (rank : 549)
Query Neighborhood Hits	185	Target Neighborhood Hits	853	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

STK24_MOUSE
θ value	θ > 10 (rank : 858)	NC score	0.071751 (rank : 546)
Query Neighborhood Hits	185	Target Neighborhood Hits	856	Shared Neighborhood Hits	40
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

STK25_HUMAN
θ value	θ > 10 (rank : 859)	NC score	0.072576 (rank : 524)
Query Neighborhood Hits	185	Target Neighborhood Hits	853	Shared Neighborhood Hits	40
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK25_MOUSE
θ value	θ > 10 (rank : 860)	NC score	0.072517 (rank : 528)
Query Neighborhood Hits	185	Target Neighborhood Hits	851	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK33_HUMAN
θ value	θ > 10 (rank : 861)	NC score	0.085876 (rank : 321)
Query Neighborhood Hits	185	Target Neighborhood Hits	879	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

STK35_HUMAN
θ value	θ > 10 (rank : 862)	NC score	0.078470 (rank : 417)
Query Neighborhood Hits	185	Target Neighborhood Hits	825	Shared Neighborhood Hits	40
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

STK36_HUMAN
θ value	θ > 10 (rank : 863)	NC score	0.082446 (rank : 382)
Query Neighborhood Hits	185	Target Neighborhood Hits	896	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK36_MOUSE
θ value	θ > 10 (rank : 864)	NC score	0.082207 (rank : 384)
Query Neighborhood Hits	185	Target Neighborhood Hits	877	Shared Neighborhood Hits	41
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK38_HUMAN
θ value	θ > 10 (rank : 865)	NC score	0.115669 (rank : 127)
Query Neighborhood Hits	185	Target Neighborhood Hits	840	Shared Neighborhood Hits	41
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK38_MOUSE
θ value	θ > 10 (rank : 866)	NC score	0.115516 (rank : 128)
Query Neighborhood Hits	185	Target Neighborhood Hits	838	Shared Neighborhood Hits	41
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK39_HUMAN
θ value	θ > 10 (rank : 867)	NC score	0.071875 (rank : 543)
Query Neighborhood Hits	185	Target Neighborhood Hits	882	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
θ value	θ > 10 (rank : 868)	NC score	0.071961 (rank : 536)
Query Neighborhood Hits	185	Target Neighborhood Hits	915	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

STK3_HUMAN
θ value	θ > 10 (rank : 869)	NC score	0.072472 (rank : 529)
Query Neighborhood Hits	185	Target Neighborhood Hits	861	Shared Neighborhood Hits	42
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

STK3_MOUSE
θ value	θ > 10 (rank : 870)	NC score	0.071821 (rank : 545)
Query Neighborhood Hits	185	Target Neighborhood Hits	869	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

STK40_HUMAN
θ value	θ > 10 (rank : 871)	NC score	0.101005 (rank : 210)
Query Neighborhood Hits	185	Target Neighborhood Hits	751	Shared Neighborhood Hits	40
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

STK40_MOUSE
θ value	θ > 10 (rank : 872)	NC score	0.100920 (rank : 211)
Query Neighborhood Hits	185	Target Neighborhood Hits	751	Shared Neighborhood Hits	40
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

STK4_HUMAN
θ value	θ > 10 (rank : 873)	NC score	0.070864 (rank : 562)
Query Neighborhood Hits	185	Target Neighborhood Hits	870	Shared Neighborhood Hits	41
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

STK4_MOUSE
θ value	θ > 10 (rank : 874)	NC score	0.071002 (rank : 560)
Query Neighborhood Hits	185	Target Neighborhood Hits	873	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

STK6_HUMAN
θ value	θ > 10 (rank : 875)	NC score	0.088267 (rank : 287)
Query Neighborhood Hits	185	Target Neighborhood Hits	916	Shared Neighborhood Hits	42
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

STK6_MOUSE
θ value	θ > 10 (rank : 876)	NC score	0.088153 (rank : 290)
Query Neighborhood Hits	185	Target Neighborhood Hits	886	Shared Neighborhood Hits	42
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

STYK1_HUMAN
θ value	θ > 10 (rank : 877)	NC score	0.056764 (rank : 812)
Query Neighborhood Hits	185	Target Neighborhood Hits	786	Shared Neighborhood Hits	40
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

STYK1_MOUSE
θ value	θ > 10 (rank : 878)	NC score	0.053028 (rank : 853)
Query Neighborhood Hits	185	Target Neighborhood Hits	779	Shared Neighborhood Hits	40
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

SYJ2B_HUMAN
θ value	θ > 10 (rank : 879)	NC score	0.113106 (rank : 141)
Query Neighborhood Hits	185	Target Neighborhood Hits	162	Shared Neighborhood Hits	41
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

SYTL2_HUMAN
θ value	θ > 10 (rank : 880)	NC score	0.052308 (rank : 863)
Query Neighborhood Hits	185	Target Neighborhood Hits	248	Shared Neighborhood Hits	14
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

TAOK1_HUMAN
θ value	θ > 10 (rank : 881)	NC score	0.064609 (rank : 679)
Query Neighborhood Hits	185	Target Neighborhood Hits	1734	Shared Neighborhood Hits	63
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

TAOK1_MOUSE
θ value	θ > 10 (rank : 882)	NC score	0.064731 (rank : 677)
Query Neighborhood Hits	185	Target Neighborhood Hits	1720	Shared Neighborhood Hits	62
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

TAOK2_HUMAN
θ value	θ > 10 (rank : 883)	NC score	0.064973 (rank : 673)
Query Neighborhood Hits	185	Target Neighborhood Hits	1172	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

TAOK2_MOUSE
θ value	θ > 10 (rank : 884)	NC score	0.064388 (rank : 683)
Query Neighborhood Hits	185	Target Neighborhood Hits	1373	Shared Neighborhood Hits	56
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

TAOK3_HUMAN
θ value	θ > 10 (rank : 885)	NC score	0.063379 (rank : 692)
Query Neighborhood Hits	185	Target Neighborhood Hits	1494	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

TAOK3_MOUSE
θ value	θ > 10 (rank : 886)	NC score	0.064863 (rank : 674)
Query Neighborhood Hits	185	Target Neighborhood Hits	1458	Shared Neighborhood Hits	57
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

TBK1_HUMAN
θ value	θ > 10 (rank : 887)	NC score	0.080093 (rank : 398)
Query Neighborhood Hits	185	Target Neighborhood Hits	861	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

TBK1_MOUSE
θ value	θ > 10 (rank : 888)	NC score	0.080897 (rank : 396)
Query Neighborhood Hits	185	Target Neighborhood Hits	893	Shared Neighborhood Hits	45
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

TCGAP_HUMAN
θ value	θ > 10 (rank : 889)	NC score	0.060271 (rank : 748)
Query Neighborhood Hits	185	Target Neighborhood Hits	872	Shared Neighborhood Hits	31
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 890)	NC score	0.066279 (rank : 645)
Query Neighborhood Hits	185	Target Neighborhood Hits	409	Shared Neighborhood Hits	23
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TEC_HUMAN
θ value	θ > 10 (rank : 891)	NC score	0.057661 (rank : 800)
Query Neighborhood Hits	185	Target Neighborhood Hits	1006	Shared Neighborhood Hits	46
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEC_MOUSE
θ value	θ > 10 (rank : 892)	NC score	0.058327 (rank : 790)
Query Neighborhood Hits	185	Target Neighborhood Hits	1006	Shared Neighborhood Hits	47
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TESK1_HUMAN
θ value	θ > 10 (rank : 893)	NC score	0.064397 (rank : 682)
Query Neighborhood Hits	185	Target Neighborhood Hits	864	Shared Neighborhood Hits	45
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK1_MOUSE
θ value	θ > 10 (rank : 894)	NC score	0.065098 (rank : 672)
Query Neighborhood Hits	185	Target Neighborhood Hits	862	Shared Neighborhood Hits	45
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK2_HUMAN
θ value	θ > 10 (rank : 895)	NC score	0.065523 (rank : 661)
Query Neighborhood Hits	185	Target Neighborhood Hits	851	Shared Neighborhood Hits	41
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TESK2_MOUSE
θ value	θ > 10 (rank : 896)	NC score	0.064115 (rank : 685)
Query Neighborhood Hits	185	Target Neighborhood Hits	833	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TIE2_HUMAN
θ value	θ > 10 (rank : 897)	NC score	0.052012 (rank : 870)
Query Neighborhood Hits	185	Target Neighborhood Hits	1192	Shared Neighborhood Hits	44
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE2_MOUSE
θ value	θ > 10 (rank : 898)	NC score	0.051805 (rank : 874)
Query Neighborhood Hits	185	Target Neighborhood Hits	1204	Shared Neighborhood Hits	44
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

TITIN_HUMAN
θ value	θ > 10 (rank : 899)	NC score	0.070627 (rank : 568)
Query Neighborhood Hits	185	Target Neighborhood Hits	2923	Shared Neighborhood Hits	86
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

TLK1_HUMAN
θ value	θ > 10 (rank : 900)	NC score	0.073283 (rank : 510)
Query Neighborhood Hits	185	Target Neighborhood Hits	967	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

TLK1_MOUSE
θ value	θ > 10 (rank : 901)	NC score	0.073069 (rank : 514)
Query Neighborhood Hits	185	Target Neighborhood Hits	947	Shared Neighborhood Hits	44
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

TLK2_HUMAN
θ value	θ > 10 (rank : 902)	NC score	0.073505 (rank : 505)
Query Neighborhood Hits	185	Target Neighborhood Hits	1044	Shared Neighborhood Hits	48
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

TLK2_MOUSE
θ value	θ > 10 (rank : 903)	NC score	0.073368 (rank : 509)
Query Neighborhood Hits	185	Target Neighborhood Hits	1088	Shared Neighborhood Hits	48
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

TNI3K_HUMAN
θ value	θ > 10 (rank : 904)	NC score	0.061263 (rank : 724)
Query Neighborhood Hits	185	Target Neighborhood Hits	1084	Shared Neighborhood Hits	41
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNI3K_MOUSE
θ value	θ > 10 (rank : 905)	NC score	0.062383 (rank : 707)
Query Neighborhood Hits	185	Target Neighborhood Hits	1079	Shared Neighborhood Hits	41
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNIK_HUMAN
θ value	θ > 10 (rank : 906)	NC score	0.071740 (rank : 548)
Query Neighborhood Hits	185	Target Neighborhood Hits	1570	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

TRIB1_HUMAN
θ value	θ > 10 (rank : 907)	NC score	0.100106 (rank : 216)
Query Neighborhood Hits	185	Target Neighborhood Hits	598	Shared Neighborhood Hits	39
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

TRIB1_MOUSE
θ value	θ > 10 (rank : 908)	NC score	0.098209 (rank : 220)
Query Neighborhood Hits	185	Target Neighborhood Hits	593	Shared Neighborhood Hits	39
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

TRIB2_HUMAN
θ value	θ > 10 (rank : 909)	NC score	0.094865 (rank : 227)
Query Neighborhood Hits	185	Target Neighborhood Hits	657	Shared Neighborhood Hits	39
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB2_MOUSE
θ value	θ > 10 (rank : 910)	NC score	0.094628 (rank : 228)
Query Neighborhood Hits	185	Target Neighborhood Hits	653	Shared Neighborhood Hits	39
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB3_HUMAN
θ value	θ > 10 (rank : 911)	NC score	0.102613 (rank : 205)
Query Neighborhood Hits	185	Target Neighborhood Hits	519	Shared Neighborhood Hits	36
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

TRIB3_MOUSE
θ value	θ > 10 (rank : 912)	NC score	0.099977 (rank : 217)
Query Neighborhood Hits	185	Target Neighborhood Hits	578	Shared Neighborhood Hits	36
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

TRIO_HUMAN
θ value	θ > 10 (rank : 913)	NC score	0.086906 (rank : 305)
Query Neighborhood Hits	185	Target Neighborhood Hits	1580	Shared Neighborhood Hits	63
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

TSSK1_HUMAN
θ value	θ > 10 (rank : 914)	NC score	0.089495 (rank : 265)
Query Neighborhood Hits	185	Target Neighborhood Hits	840	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

TSSK1_MOUSE
θ value	θ > 10 (rank : 915)	NC score	0.084424 (rank : 347)
Query Neighborhood Hits	185	Target Neighborhood Hits	835	Shared Neighborhood Hits	40
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

TSSK2_HUMAN
θ value	θ > 10 (rank : 916)	NC score	0.087887 (rank : 295)
Query Neighborhood Hits	185	Target Neighborhood Hits	826	Shared Neighborhood Hits	40
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

TSSK2_MOUSE
θ value	θ > 10 (rank : 917)	NC score	0.089348 (rank : 268)
Query Neighborhood Hits	185	Target Neighborhood Hits	819	Shared Neighborhood Hits	40
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

TSSK3_HUMAN
θ value	θ > 10 (rank : 918)	NC score	0.081632 (rank : 391)
Query Neighborhood Hits	185	Target Neighborhood Hits	806	Shared Neighborhood Hits	40
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

TSSK3_MOUSE
θ value	θ > 10 (rank : 919)	NC score	0.081748 (rank : 390)
Query Neighborhood Hits	185	Target Neighborhood Hits	806	Shared Neighborhood Hits	40
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

TSSK4_HUMAN
θ value	θ > 10 (rank : 920)	NC score	0.091218 (rank : 245)
Query Neighborhood Hits	185	Target Neighborhood Hits	836	Shared Neighborhood Hits	40
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

TSSK4_MOUSE
θ value	θ > 10 (rank : 921)	NC score	0.091337 (rank : 243)
Query Neighborhood Hits	185	Target Neighborhood Hits	840	Shared Neighborhood Hits	40
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

TSSK6_HUMAN
θ value	θ > 10 (rank : 922)	NC score	0.085980 (rank : 318)
Query Neighborhood Hits	185	Target Neighborhood Hits	824	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

TSSK6_MOUSE
θ value	θ > 10 (rank : 923)	NC score	0.084567 (rank : 341)
Query Neighborhood Hits	185	Target Neighborhood Hits	824	Shared Neighborhood Hits	40
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

TTBK1_HUMAN
θ value	θ > 10 (rank : 924)	NC score	0.050825 (rank : 888)
Query Neighborhood Hits	185	Target Neighborhood Hits	1058	Shared Neighborhood Hits	49
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

TTK_HUMAN
θ value	θ > 10 (rank : 925)	NC score	0.073050 (rank : 517)
Query Neighborhood Hits	185	Target Neighborhood Hits	816	Shared Neighborhood Hits	40
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

TTK_MOUSE
θ value	θ > 10 (rank : 926)	NC score	0.074674 (rank : 487)
Query Neighborhood Hits	185	Target Neighborhood Hits	803	Shared Neighborhood Hits	39
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

TX1B3_HUMAN
θ value	θ > 10 (rank : 927)	NC score	0.123724 (rank : 88)
Query Neighborhood Hits	185	Target Neighborhood Hits	161	Shared Neighborhood Hits	43
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
θ value	θ > 10 (rank : 928)	NC score	0.123665 (rank : 89)
Query Neighborhood Hits	185	Target Neighborhood Hits	158	Shared Neighborhood Hits	43
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

TXK_HUMAN
θ value	θ > 10 (rank : 929)	NC score	0.057698 (rank : 798)
Query Neighborhood Hits	185	Target Neighborhood Hits	971	Shared Neighborhood Hits	44
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TXK_MOUSE
θ value	θ > 10 (rank : 930)	NC score	0.054067 (rank : 847)
Query Neighborhood Hits	185	Target Neighborhood Hits	980	Shared Neighborhood Hits	44
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

TYK2_HUMAN
θ value	θ > 10 (rank : 931)	NC score	0.055998 (rank : 824)
Query Neighborhood Hits	185	Target Neighborhood Hits	841	Shared Neighborhood Hits	40
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYK2_MOUSE
θ value	θ > 10 (rank : 932)	NC score	0.052538 (rank : 862)
Query Neighborhood Hits	185	Target Neighborhood Hits	850	Shared Neighborhood Hits	40
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYRO3_HUMAN
θ value	θ > 10 (rank : 933)	NC score	0.050958 (rank : 886)
Query Neighborhood Hits	185	Target Neighborhood Hits	995	Shared Neighborhood Hits	39
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

TYRO3_MOUSE
θ value	θ > 10 (rank : 934)	NC score	0.051149 (rank : 880)
Query Neighborhood Hits	185	Target Neighborhood Hits	1007	Shared Neighborhood Hits	39
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

UHMK1_HUMAN
θ value	θ > 10 (rank : 935)	NC score	0.067554 (rank : 629)
Query Neighborhood Hits	185	Target Neighborhood Hits	808	Shared Neighborhood Hits	40
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

UHMK1_MOUSE
θ value	θ > 10 (rank : 936)	NC score	0.067639 (rank : 626)
Query Neighborhood Hits	185	Target Neighborhood Hits	809	Shared Neighborhood Hits	40
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

ULK1_HUMAN
θ value	θ > 10 (rank : 937)	NC score	0.081620 (rank : 392)
Query Neighborhood Hits	185	Target Neighborhood Hits	1121	Shared Neighborhood Hits	45
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

ULK1_MOUSE
θ value	θ > 10 (rank : 938)	NC score	0.082064 (rank : 386)
Query Neighborhood Hits	185	Target Neighborhood Hits	1214	Shared Neighborhood Hits	49
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

ULK2_HUMAN
θ value	θ > 10 (rank : 939)	NC score	0.082783 (rank : 374)
Query Neighborhood Hits	185	Target Neighborhood Hits	979	Shared Neighborhood Hits	43
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

ULK2_MOUSE
θ value	θ > 10 (rank : 940)	NC score	0.082916 (rank : 372)
Query Neighborhood Hits	185	Target Neighborhood Hits	943	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

ULK3_HUMAN
θ value	θ > 10 (rank : 941)	NC score	0.082985 (rank : 371)
Query Neighborhood Hits	185	Target Neighborhood Hits	830	Shared Neighborhood Hits	40
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

ULK3_MOUSE
θ value	θ > 10 (rank : 942)	NC score	0.083493 (rank : 358)
Query Neighborhood Hits	185	Target Neighborhood Hits	872	Shared Neighborhood Hits	41
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

ULK4_MOUSE
θ value	θ > 10 (rank : 943)	NC score	0.097129 (rank : 222)
Query Neighborhood Hits	185	Target Neighborhood Hits	793	Shared Neighborhood Hits	40
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

UN13D_HUMAN
θ value	θ > 10 (rank : 944)	NC score	0.059493 (rank : 767)
Query Neighborhood Hits	185	Target Neighborhood Hits	117	Shared Neighborhood Hits	10
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

USH1C_HUMAN
θ value	θ > 10 (rank : 945)	NC score	0.119513 (rank : 105)
Query Neighborhood Hits	185	Target Neighborhood Hits	327	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

USH1C_MOUSE
θ value	θ > 10 (rank : 946)	NC score	0.112326 (rank : 150)
Query Neighborhood Hits	185	Target Neighborhood Hits	557	Shared Neighborhood Hits	63
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

VAV2_HUMAN
θ value	θ > 10 (rank : 947)	NC score	0.103301 (rank : 197)
Query Neighborhood Hits	185	Target Neighborhood Hits	453	Shared Neighborhood Hits	56
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	θ > 10 (rank : 948)	NC score	0.100392 (rank : 214)
Query Neighborhood Hits	185	Target Neighborhood Hits	456	Shared Neighborhood Hits	53
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	θ > 10 (rank : 949)	NC score	0.099211 (rank : 218)
Query Neighborhood Hits	185	Target Neighborhood Hits	398	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 950)	NC score	0.097831 (rank : 221)
Query Neighborhood Hits	185	Target Neighborhood Hits	404	Shared Neighborhood Hits	52
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

WEE1B_HUMAN
θ value	θ > 10 (rank : 951)	NC score	0.067122 (rank : 632)
Query Neighborhood Hits	185	Target Neighborhood Hits	836	Shared Neighborhood Hits	43
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

WEE1B_MOUSE
θ value	θ > 10 (rank : 952)	NC score	0.072678 (rank : 521)
Query Neighborhood Hits	185	Target Neighborhood Hits	765	Shared Neighborhood Hits	44
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

WEE1_HUMAN
θ value	θ > 10 (rank : 953)	NC score	0.061030 (rank : 728)
Query Neighborhood Hits	185	Target Neighborhood Hits	777	Shared Neighborhood Hits	42
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

WEE1_MOUSE
θ value	θ > 10 (rank : 954)	NC score	0.060905 (rank : 734)
Query Neighborhood Hits	185	Target Neighborhood Hits	794	Shared Neighborhood Hits	43
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

WNK1_HUMAN
θ value	θ > 10 (rank : 955)	NC score	0.076083 (rank : 454)
Query Neighborhood Hits	185	Target Neighborhood Hits	1158	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

WNK1_MOUSE
θ value	θ > 10 (rank : 956)	NC score	0.074799 (rank : 482)
Query Neighborhood Hits	185	Target Neighborhood Hits	1179	Shared Neighborhood Hits	52
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

WNK2_HUMAN
θ value	θ > 10 (rank : 957)	NC score	0.075416 (rank : 469)
Query Neighborhood Hits	185	Target Neighborhood Hits	1407	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

WNK3_HUMAN
θ value	θ > 10 (rank : 958)	NC score	0.073039 (rank : 519)
Query Neighborhood Hits	185	Target Neighborhood Hits	948	Shared Neighborhood Hits	42
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

WNK4_HUMAN
θ value	θ > 10 (rank : 959)	NC score	0.074799 (rank : 483)
Query Neighborhood Hits	185	Target Neighborhood Hits	1043	Shared Neighborhood Hits	53
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

WNK4_MOUSE
θ value	θ > 10 (rank : 960)	NC score	0.074524 (rank : 489)
Query Neighborhood Hits	185	Target Neighborhood Hits	961	Shared Neighborhood Hits	51
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

YSK4_HUMAN
θ value	θ > 10 (rank : 961)	NC score	0.069963 (rank : 581)
Query Neighborhood Hits	185	Target Neighborhood Hits	921	Shared Neighborhood Hits	42
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

ZAP70_HUMAN
θ value	θ > 10 (rank : 962)	NC score	0.057958 (rank : 795)
Query Neighborhood Hits	185	Target Neighborhood Hits	893	Shared Neighborhood Hits	44
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	θ > 10 (rank : 963)	NC score	0.057385 (rank : 807)
Query Neighborhood Hits	185	Target Neighborhood Hits	905	Shared Neighborhood Hits	44
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZO2_MOUSE
θ value	θ > 10 (rank : 964)	NC score	0.109605 (rank : 165)
Query Neighborhood Hits	185	Target Neighborhood Hits	296	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZO3_HUMAN
θ value	θ > 10 (rank : 965)	NC score	0.108724 (rank : 173)
Query Neighborhood Hits	185	Target Neighborhood Hits	219	Shared Neighborhood Hits	47
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

Hits sorted by NC score

PDZD8_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	185	Target Neighborhood Hits	185	Shared Neighborhood Hits	185
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

RASF1_MOUSE
NC score	0.337835 (rank : 2)	θ value	0.00102713 (rank : 14)
Query Neighborhood Hits	185	Target Neighborhood Hits	74	Shared Neighborhood Hits	52
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

GRP3_HUMAN
NC score	0.334899 (rank : 3)	θ value	0.00298849 (rank : 27)
Query Neighborhood Hits	185	Target Neighborhood Hits	131	Shared Neighborhood Hits	61
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

RASF1_HUMAN
NC score	0.285358 (rank : 4)	θ value	0.21417 (rank : 61)
Query Neighborhood Hits	185	Target Neighborhood Hits	62	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NS23, O14571, O60539, O60710, Q9HB04, Q9HB18, Q9NS22, Q9UND4, Q9UND5	Gene names	RASSF1, RDA32
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1.

UN13A_HUMAN
NC score	0.284804 (rank : 5)	θ value	0.0563607 (rank : 44)
Query Neighborhood Hits	185	Target Neighborhood Hits	285	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

CHIO_MOUSE
NC score	0.278954 (rank : 6)	θ value	0.00665767 (rank : 29)
Query Neighborhood Hits	185	Target Neighborhood Hits	130	Shared Neighborhood Hits	57
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

UN13B_HUMAN
NC score	0.277327 (rank : 7)	θ value	0.0961366 (rank : 50)
Query Neighborhood Hits	185	Target Neighborhood Hits	217	Shared Neighborhood Hits	64
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_MOUSE
NC score	0.275824 (rank : 8)	θ value	0.0330416 (rank : 38)
Query Neighborhood Hits	185	Target Neighborhood Hits	210	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

CHIO_HUMAN
NC score	0.273291 (rank : 9)	θ value	0.00298849 (rank : 26)
Query Neighborhood Hits	185	Target Neighborhood Hits	220	Shared Neighborhood Hits	57
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIN_HUMAN
NC score	0.269235 (rank : 10)	θ value	0.00228821 (rank : 23)
Query Neighborhood Hits	185	Target Neighborhood Hits	227	Shared Neighborhood Hits	57
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
NC score	0.268779 (rank : 11)	θ value	0.00298849 (rank : 25)
Query Neighborhood Hits	185	Target Neighborhood Hits	229	Shared Neighborhood Hits	57
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

DGKQ_HUMAN
NC score	0.264731 (rank : 12)	θ value	0.0148317 (rank : 34)
Query Neighborhood Hits	185	Target Neighborhood Hits	131	Shared Neighborhood Hits	60
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

STAC_MOUSE
NC score	0.232500 (rank : 13)	θ value	0.163984 (rank : 58)
Query Neighborhood Hits	185	Target Neighborhood Hits	268	Shared Neighborhood Hits	61
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC3_HUMAN
NC score	0.231302 (rank : 14)	θ value	0.365318 (rank : 73)
Query Neighborhood Hits	185	Target Neighborhood Hits	228	Shared Neighborhood Hits	57
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
NC score	0.230589 (rank : 15)	θ value	0.62314 (rank : 85)
Query Neighborhood Hits	185	Target Neighborhood Hits	232	Shared Neighborhood Hits	57
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
NC score	0.226783 (rank : 16)	θ value	0.0961366 (rank : 49)
Query Neighborhood Hits	185	Target Neighborhood Hits	276	Shared Neighborhood Hits	56
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

PDZD1_HUMAN
NC score	0.221349 (rank : 17)	θ value	0.000602161 (rank : 7)
Query Neighborhood Hits	185	Target Neighborhood Hits	190	Shared Neighborhood Hits	44
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PDZD1_MOUSE
NC score	0.215900 (rank : 18)	θ value	0.00298849 (rank : 28)
Query Neighborhood Hits	185	Target Neighborhood Hits	191	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

DGKG_MOUSE
NC score	0.211804 (rank : 19)	θ value	0.00665767 (rank : 30)
Query Neighborhood Hits	185	Target Neighborhood Hits	188	Shared Neighborhood Hits	54
SwissProt Accessions	Q91WG7	Gene names	Dgkg, Dagk3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma) (88 kDa diacylglycerol kinase).

RASF5_MOUSE
NC score	0.203911 (rank : 20)	θ value	0.0431538 (rank : 42)
Query Neighborhood Hits	185	Target Neighborhood Hits	72	Shared Neighborhood Hits	46
SwissProt Accessions	Q5EBH1, O70407, Q6KAR0, Q8C2E8	Gene names	Rassf5, Nore1, Rapl
Domain Architecture	No domain graphic available
Description	Ras association domain-containing family protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL).

DGKG_HUMAN
NC score	0.202009 (rank : 21)	θ value	0.21417 (rank : 60)
Query Neighborhood Hits	185	Target Neighborhood Hits	171	Shared Neighborhood Hits	56
SwissProt Accessions	P49619	Gene names	DGKG, DAGK3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma).

DGKB_HUMAN
NC score	0.192945 (rank : 22)	θ value	6.88961 (rank : 158)
Query Neighborhood Hits	185	Target Neighborhood Hits	238	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y6T7, O75241, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29	Gene names	DGKB, DAGK2, KIAA0718
Domain Architecture
Description	Diacylglycerol kinase beta (EC 2.7.1.107) (Diglyceride kinase beta) (DGK-beta) (DAG kinase beta) (90 kDa diacylglycerol kinase).

NHRF2_HUMAN
NC score	0.191378 (rank : 23)	θ value	0.0431538 (rank : 40)
Query Neighborhood Hits	185	Target Neighborhood Hits	197	Shared Neighborhood Hits	46
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

PDZD3_HUMAN
NC score	0.190550 (rank : 24)	θ value	0.163984 (rank : 56)
Query Neighborhood Hits	185	Target Neighborhood Hits	180	Shared Neighborhood Hits	43
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

RASF5_HUMAN
NC score	0.190341 (rank : 25)	θ value	0.279714 (rank : 68)
Query Neighborhood Hits	185	Target Neighborhood Hits	79	Shared Neighborhood Hits	44
SwissProt Accessions	Q8WWW0, Q5SY32, Q8WWV9, Q8WXF4, Q9BT99	Gene names	RASSF5, NORE1, RAPL
Domain Architecture	No domain graphic available
Description	Ras association domain-containing family protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL).

NHRF2_MOUSE
NC score	0.188319 (rank : 26)	θ value	0.0431538 (rank : 41)
Query Neighborhood Hits	185	Target Neighborhood Hits	194	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

DGKD_HUMAN
NC score	0.182719 (rank : 27)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	185	Target Neighborhood Hits	231	Shared Neighborhood Hits	55
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

DGKH_HUMAN
NC score	0.180906 (rank : 28)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	185	Target Neighborhood Hits	255	Shared Neighborhood Hits	57
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

KPCE_HUMAN
NC score	0.178636 (rank : 29)	θ value	0.00020696 (rank : 2)
Query Neighborhood Hits	185	Target Neighborhood Hits	906	Shared Neighborhood Hits	72
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCE_MOUSE
NC score	0.178171 (rank : 30)	θ value	0.00020696 (rank : 3)
Query Neighborhood Hits	185	Target Neighborhood Hits	906	Shared Neighborhood Hits	70
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCL_HUMAN
NC score	0.177182 (rank : 31)	θ value	0.000270298 (rank : 4)
Query Neighborhood Hits	185	Target Neighborhood Hits	887	Shared Neighborhood Hits	70
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KPCB_HUMAN
NC score	0.175345 (rank : 32)	θ value	0.000786445 (rank : 8)
Query Neighborhood Hits	185	Target Neighborhood Hits	1121	Shared Neighborhood Hits	70
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_MOUSE
NC score	0.175017 (rank : 33)	θ value	0.000786445 (rank : 9)
Query Neighborhood Hits	185	Target Neighborhood Hits	1117	Shared Neighborhood Hits	70
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCL_MOUSE
NC score	0.174902 (rank : 34)	θ value	0.000270298 (rank : 5)
Query Neighborhood Hits	185	Target Neighborhood Hits	891	Shared Neighborhood Hits	71
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KPCD_MOUSE
NC score	0.174119 (rank : 35)	θ value	0.00228821 (rank : 24)
Query Neighborhood Hits	185	Target Neighborhood Hits	888	Shared Neighborhood Hits	72
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCD_HUMAN
NC score	0.174040 (rank : 36)	θ value	0.00175202 (rank : 21)
Query Neighborhood Hits	185	Target Neighborhood Hits	900	Shared Neighborhood Hits	72
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCG_HUMAN
NC score	0.173716 (rank : 37)	θ value	0.00134147 (rank : 18)
Query Neighborhood Hits	185	Target Neighborhood Hits	1126	Shared Neighborhood Hits	72
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCG_MOUSE
NC score	0.173654 (rank : 38)	θ value	0.00134147 (rank : 19)
Query Neighborhood Hits	185	Target Neighborhood Hits	1123	Shared Neighborhood Hits	72
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

PDZD3_MOUSE
NC score	0.172418 (rank : 39)	θ value	3.0926 (rank : 128)
Query Neighborhood Hits	185	Target Neighborhood Hits	171	Shared Neighborhood Hits	42
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

NHERF_HUMAN
NC score	0.172221 (rank : 40)	θ value	2.36792 (rank : 116)
Query Neighborhood Hits	185	Target Neighborhood Hits	190	Shared Neighborhood Hits	45
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

KPCA_HUMAN
NC score	0.170704 (rank : 41)	θ value	0.00134147 (rank : 15)
Query Neighborhood Hits	185	Target Neighborhood Hits	1070	Shared Neighborhood Hits	72
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCT_MOUSE
NC score	0.170553 (rank : 42)	θ value	0.000786445 (rank : 11)
Query Neighborhood Hits	185	Target Neighborhood Hits	895	Shared Neighborhood Hits	69
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPCT_HUMAN
NC score	0.170286 (rank : 43)	θ value	0.000786445 (rank : 10)
Query Neighborhood Hits	185	Target Neighborhood Hits	897	Shared Neighborhood Hits	69
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPCA_MOUSE
NC score	0.170282 (rank : 44)	θ value	0.00134147 (rank : 16)
Query Neighborhood Hits	185	Target Neighborhood Hits	1067	Shared Neighborhood Hits	72
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

NHERF_MOUSE
NC score	0.167553 (rank : 45)	θ value	8.99809 (rank : 182)
Query Neighborhood Hits	185	Target Neighborhood Hits	195	Shared Neighborhood Hits	44
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

KPCZ_HUMAN
NC score	0.160781 (rank : 46)	θ value	0.0736092 (rank : 47)
Query Neighborhood Hits	185	Target Neighborhood Hits	884	Shared Neighborhood Hits	71
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KPCZ_MOUSE
NC score	0.160392 (rank : 47)	θ value	0.0563607 (rank : 43)
Query Neighborhood Hits	185	Target Neighborhood Hits	882	Shared Neighborhood Hits	70
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

SDCB1_MOUSE
NC score	0.159847 (rank : 48)	θ value	0.21417 (rank : 62)
Query Neighborhood Hits	185	Target Neighborhood Hits	144	Shared Neighborhood Hits	44
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

KPCI_MOUSE
NC score	0.154320 (rank : 49)	θ value	0.125558 (rank : 52)
Query Neighborhood Hits	185	Target Neighborhood Hits	888	Shared Neighborhood Hits	70
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

KPCI_HUMAN
NC score	0.154034 (rank : 50)	θ value	0.125558 (rank : 51)
Query Neighborhood Hits	185	Target Neighborhood Hits	885	Shared Neighborhood Hits	68
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

SDCB1_HUMAN
NC score	0.152481 (rank : 51)	θ value	0.47712 (rank : 80)
Query Neighborhood Hits	185	Target Neighborhood Hits	150	Shared Neighborhood Hits	44
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

WHRN_MOUSE
NC score	0.152476 (rank : 52)	θ value	0.163984 (rank : 59)
Query Neighborhood Hits	185	Target Neighborhood Hits	412	Shared Neighborhood Hits	54
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

DLG3_MOUSE
NC score	0.151167 (rank : 53)	θ value	0.00869519 (rank : 33)
Query Neighborhood Hits	185	Target Neighborhood Hits	274	Shared Neighborhood Hits	45
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

DLG3_HUMAN
NC score	0.150733 (rank : 54)	θ value	0.00869519 (rank : 32)
Query Neighborhood Hits	185	Target Neighborhood Hits	269	Shared Neighborhood Hits	45
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG1_MOUSE
NC score	0.148548 (rank : 55)	θ value	0.0330416 (rank : 37)
Query Neighborhood Hits	185	Target Neighborhood Hits	285	Shared Neighborhood Hits	42
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

DLG1_HUMAN
NC score	0.147306 (rank : 56)	θ value	0.0330416 (rank : 36)
Query Neighborhood Hits	185	Target Neighborhood Hits	290	Shared Neighborhood Hits	41
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

DGKA_HUMAN
NC score	0.146432 (rank : 57)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	185	Target Neighborhood Hits	151	Shared Neighborhood Hits	51
SwissProt Accessions	P23743, O75481, O75482, O75483	Gene names	DGKA, DAGK, DAGK1
Domain Architecture
Description	Diacylglycerol kinase alpha (EC 2.7.1.107) (Diglyceride kinase alpha) (DGK-alpha) (DAG kinase alpha) (80 kDa diacylglycerol kinase).

KPCD3_HUMAN
NC score	0.145678 (rank : 58)	θ value	0.00134147 (rank : 17)
Query Neighborhood Hits	185	Target Neighborhood Hits	895	Shared Neighborhood Hits	71
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

KPCD3_MOUSE
NC score	0.142588 (rank : 59)	θ value	0.00175202 (rank : 20)
Query Neighborhood Hits	185	Target Neighborhood Hits	901	Shared Neighborhood Hits	73
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

DLG2_HUMAN
NC score	0.142530 (rank : 60)	θ value	0.163984 (rank : 54)
Query Neighborhood Hits	185	Target Neighborhood Hits	279	Shared Neighborhood Hits	45
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG2_MOUSE
NC score	0.142387 (rank : 61)	θ value	0.163984 (rank : 55)
Query Neighborhood Hits	185	Target Neighborhood Hits	271	Shared Neighborhood Hits	45
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

MAST1_HUMAN
NC score	0.141644 (rank : 62)	θ value	0.279714 (rank : 64)
Query Neighborhood Hits	185	Target Neighborhood Hits	1146	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST4_HUMAN
NC score	0.141142 (rank : 63)	θ value	0.279714 (rank : 65)
Query Neighborhood Hits	185	Target Neighborhood Hits	1804	Shared Neighborhood Hits	95
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

KPCD1_HUMAN
NC score	0.140726 (rank : 64)	θ value	0.000461057 (rank : 6)
Query Neighborhood Hits	185	Target Neighborhood Hits	901	Shared Neighborhood Hits	70
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

WHRN_HUMAN
NC score	0.140675 (rank : 65)	θ value	1.06291 (rank : 94)
Query Neighborhood Hits	185	Target Neighborhood Hits	325	Shared Neighborhood Hits	48
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

MAST1_MOUSE
NC score	0.140318 (rank : 66)	θ value	0.813845 (rank : 89)
Query Neighborhood Hits	185	Target Neighborhood Hits	1123	Shared Neighborhood Hits	76
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

KPCD1_MOUSE
NC score	0.140124 (rank : 67)	θ value	0.00102713 (rank : 13)
Query Neighborhood Hits	185	Target Neighborhood Hits	891	Shared Neighborhood Hits	70
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

MAST2_HUMAN
NC score	0.139192 (rank : 68)	θ value	0.813845 (rank : 90)
Query Neighborhood Hits	185	Target Neighborhood Hits	1189	Shared Neighborhood Hits	83
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST3_HUMAN
NC score	0.138644 (rank : 69)	θ value	0.62314 (rank : 82)
Query Neighborhood Hits	185	Target Neighborhood Hits	1128	Shared Neighborhood Hits	83
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MAST2_MOUSE
NC score	0.138582 (rank : 70)	θ value	0.47712 (rank : 76)
Query Neighborhood Hits	185	Target Neighborhood Hits	1110	Shared Neighborhood Hits	75
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

SDCB2_HUMAN
NC score	0.138275 (rank : 71)	θ value	0.62314 (rank : 84)
Query Neighborhood Hits	185	Target Neighborhood Hits	121	Shared Neighborhood Hits	35
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

KPCD2_HUMAN
NC score	0.136377 (rank : 72)	θ value	0.0252991 (rank : 35)
Query Neighborhood Hits	185	Target Neighborhood Hits	910	Shared Neighborhood Hits	70
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

DLG4_MOUSE
NC score	0.132416 (rank : 73)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	185	Target Neighborhood Hits	282	Shared Neighborhood Hits	48
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_HUMAN
NC score	0.132394 (rank : 74)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	185	Target Neighborhood Hits	286	Shared Neighborhood Hits	48
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

MRCKB_MOUSE
NC score	0.132241 (rank : 75)	θ value	0.47712 (rank : 77)
Query Neighborhood Hits	185	Target Neighborhood Hits	2180	Shared Neighborhood Hits	95
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

RPKL1_HUMAN
NC score	0.130648 (rank : 76)	θ value	θ > 10 (rank : 804)
Query Neighborhood Hits	185	Target Neighborhood Hits	708	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

RPKL1_MOUSE
NC score	0.130614 (rank : 77)	θ value	θ > 10 (rank : 805)
Query Neighborhood Hits	185	Target Neighborhood Hits	704	Shared Neighborhood Hits	41
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

ARHGC_HUMAN
NC score	0.130443 (rank : 78)	θ value	0.0736092 (rank : 45)
Query Neighborhood Hits	185	Target Neighborhood Hits	351	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

INADL_MOUSE
NC score	0.129692 (rank : 79)	θ value	0.47712 (rank : 75)
Query Neighborhood Hits	185	Target Neighborhood Hits	290	Shared Neighborhood Hits	48
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

MRCKB_HUMAN
NC score	0.128833 (rank : 80)	θ value	0.813845 (rank : 91)
Query Neighborhood Hits	185	Target Neighborhood Hits	2239	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MRCKG_HUMAN
NC score	0.128545 (rank : 81)	θ value	θ > 10 (rank : 641)
Query Neighborhood Hits	185	Target Neighborhood Hits	1519	Shared Neighborhood Hits	81
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

MRCKG_MOUSE
NC score	0.128027 (rank : 82)	θ value	θ > 10 (rank : 642)
Query Neighborhood Hits	185	Target Neighborhood Hits	1466	Shared Neighborhood Hits	76
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

MRCKA_HUMAN
NC score	0.127687 (rank : 83)	θ value	θ > 10 (rank : 640)
Query Neighborhood Hits	185	Target Neighborhood Hits	1999	Shared Neighborhood Hits	87
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

ARHGB_HUMAN
NC score	0.127463 (rank : 84)	θ value	0.0961366 (rank : 48)
Query Neighborhood Hits	185	Target Neighborhood Hits	375	Shared Neighborhood Hits	55
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

SDCB2_MOUSE
NC score	0.126655 (rank : 85)	θ value	1.38821 (rank : 98)
Query Neighborhood Hits	185	Target Neighborhood Hits	118	Shared Neighborhood Hits	32
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

ARHGC_MOUSE
NC score	0.125498 (rank : 86)	θ value	0.163984 (rank : 53)
Query Neighborhood Hits	185	Target Neighborhood Hits	344	Shared Neighborhood Hits	54
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ZO3_MOUSE
NC score	0.124650 (rank : 87)	θ value	2.36792 (rank : 120)
Query Neighborhood Hits	185	Target Neighborhood Hits	224	Shared Neighborhood Hits	46
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

TX1B3_HUMAN
NC score	0.123724 (rank : 88)	θ value	θ > 10 (rank : 927)
Query Neighborhood Hits	185	Target Neighborhood Hits	161	Shared Neighborhood Hits	43
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
NC score	0.123665 (rank : 89)	θ value	θ > 10 (rank : 928)
Query Neighborhood Hits	185	Target Neighborhood Hits	158	Shared Neighborhood Hits	43
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

KS6C1_MOUSE
NC score	0.123618 (rank : 90)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	185	Target Neighborhood Hits	700	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

DMPK_HUMAN
NC score	0.122383 (rank : 91)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	185	Target Neighborhood Hits	944	Shared Neighborhood Hits	48
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

PKN1_HUMAN
NC score	0.122197 (rank : 92)	θ value	θ > 10 (rank : 733)
Query Neighborhood Hits	185	Target Neighborhood Hits	886	Shared Neighborhood Hits	41
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

PKN3_HUMAN
NC score	0.122167 (rank : 93)	θ value	θ > 10 (rank : 737)
Query Neighborhood Hits	185	Target Neighborhood Hits	893	Shared Neighborhood Hits	43
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PKN1_MOUSE
NC score	0.122027 (rank : 94)	θ value	θ > 10 (rank : 734)
Query Neighborhood Hits	185	Target Neighborhood Hits	888	Shared Neighborhood Hits	40
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

DMPK_MOUSE
NC score	0.122001 (rank : 95)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	185	Target Neighborhood Hits	908	Shared Neighborhood Hits	46
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

PKN2_HUMAN
NC score	0.121122 (rank : 96)	θ value	θ > 10 (rank : 735)
Query Neighborhood Hits	185	Target Neighborhood Hits	892	Shared Neighborhood Hits	40
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

KS6C1_HUMAN
NC score	0.121078 (rank : 97)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	185	Target Neighborhood Hits	682	Shared Neighborhood Hits	40
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

PKN2_MOUSE
NC score	0.120993 (rank : 98)	θ value	θ > 10 (rank : 736)
Query Neighborhood Hits	185	Target Neighborhood Hits	899	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

LATS1_MOUSE
NC score	0.120592 (rank : 99)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	185	Target Neighborhood Hits	1027	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

PKN3_MOUSE
NC score	0.120426 (rank : 100)	θ value	θ > 10 (rank : 738)
Query Neighborhood Hits	185	Target Neighborhood Hits	1009	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

LATS1_HUMAN
NC score	0.120032 (rank : 101)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	185	Target Neighborhood Hits	1057	Shared Neighborhood Hits	55
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

AKT1_MOUSE
NC score	0.119754 (rank : 102)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	185	Target Neighborhood Hits	878	Shared Neighborhood Hits	40
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

PARD3_MOUSE
NC score	0.119653 (rank : 103)	θ value	1.81305 (rank : 107)
Query Neighborhood Hits	185	Target Neighborhood Hits	290	Shared Neighborhood Hits	44
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

AKT1_HUMAN
NC score	0.119642 (rank : 104)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	185	Target Neighborhood Hits	885	Shared Neighborhood Hits	41
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

USH1C_HUMAN
NC score	0.119513 (rank : 105)	θ value	θ > 10 (rank : 945)
Query Neighborhood Hits	185	Target Neighborhood Hits	327	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

DGKA_MOUSE
NC score	0.118866 (rank : 106)	θ value	3.0926 (rank : 123)
Query Neighborhood Hits	185	Target Neighborhood Hits	146	Shared Neighborhood Hits	37
SwissProt Accessions	O88673, Q922X2	Gene names	Dgka, Dagk1
Domain Architecture
Description	Diacylglycerol kinase alpha (EC 2.7.1.107) (Diglyceride kinase alpha) (DGK-alpha) (DAG kinase alpha) (80 kDa diacylglycerol kinase).

ROCK2_MOUSE
NC score	0.118772 (rank : 107)	θ value	0.279714 (rank : 69)
Query Neighborhood Hits	185	Target Neighborhood Hits	2072	Shared Neighborhood Hits	72
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

SGK2_HUMAN
NC score	0.118481 (rank : 108)	θ value	θ > 10 (rank : 812)
Query Neighborhood Hits	185	Target Neighborhood Hits	840	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

ROCK2_HUMAN
NC score	0.118318 (rank : 109)	θ value	0.47712 (rank : 79)
Query Neighborhood Hits	185	Target Neighborhood Hits	2073	Shared Neighborhood Hits	74
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

AKT2_MOUSE
NC score	0.118006 (rank : 110)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	185	Target Neighborhood Hits	875	Shared Neighborhood Hits	40
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT2_HUMAN
NC score	0.117990 (rank : 111)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	185	Target Neighborhood Hits	878	Shared Neighborhood Hits	40
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT3_MOUSE
NC score	0.117884 (rank : 112)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	185	Target Neighborhood Hits	872	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

AKT3_HUMAN
NC score	0.117865 (rank : 113)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	185	Target Neighborhood Hits	872	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

SGK3_HUMAN
NC score	0.117798 (rank : 114)	θ value	θ > 10 (rank : 814)
Query Neighborhood Hits	185	Target Neighborhood Hits	877	Shared Neighborhood Hits	40
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

LATS2_MOUSE
NC score	0.117739 (rank : 115)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	185	Target Neighborhood Hits	879	Shared Neighborhood Hits	41
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

PARD3_HUMAN
NC score	0.117593 (rank : 116)	θ value	4.03905 (rank : 136)
Query Neighborhood Hits	185	Target Neighborhood Hits	312	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

SGK2_MOUSE
NC score	0.117536 (rank : 117)	θ value	θ > 10 (rank : 813)
Query Neighborhood Hits	185	Target Neighborhood Hits	833	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

SGK3_MOUSE
NC score	0.117521 (rank : 118)	θ value	θ > 10 (rank : 815)
Query Neighborhood Hits	185	Target Neighborhood Hits	882	Shared Neighborhood Hits	40
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

ZO1_HUMAN
NC score	0.117505 (rank : 119)	θ value	1.81305 (rank : 109)
Query Neighborhood Hits	185	Target Neighborhood Hits	474	Shared Neighborhood Hits	58
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

SGK1_MOUSE
NC score	0.117405 (rank : 120)	θ value	θ > 10 (rank : 811)
Query Neighborhood Hits	185	Target Neighborhood Hits	848	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

SGK1_HUMAN
NC score	0.117218 (rank : 121)	θ value	θ > 10 (rank : 810)
Query Neighborhood Hits	185	Target Neighborhood Hits	848	Shared Neighborhood Hits	40
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

ST38L_MOUSE
NC score	0.117180 (rank : 122)	θ value	θ > 10 (rank : 851)
Query Neighborhood Hits	185	Target Neighborhood Hits	821	Shared Neighborhood Hits	40
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

LATS2_HUMAN
NC score	0.117080 (rank : 123)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	185	Target Neighborhood Hits	884	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

ZO1_MOUSE
NC score	0.117052 (rank : 124)	θ value	1.81305 (rank : 110)
Query Neighborhood Hits	185	Target Neighborhood Hits	453	Shared Neighborhood Hits	57
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ST38L_HUMAN
NC score	0.116157 (rank : 125)	θ value	θ > 10 (rank : 850)
Query Neighborhood Hits	185	Target Neighborhood Hits	824	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

PDZD7_HUMAN
NC score	0.115992 (rank : 126)	θ value	θ > 10 (rank : 717)
Query Neighborhood Hits	185	Target Neighborhood Hits	181	Shared Neighborhood Hits	43
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

STK38_HUMAN
NC score	0.115669 (rank : 127)	θ value	θ > 10 (rank : 865)
Query Neighborhood Hits	185	Target Neighborhood Hits	840	Shared Neighborhood Hits	41
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK38_MOUSE
NC score	0.115516 (rank : 128)	θ value	θ > 10 (rank : 866)
Query Neighborhood Hits	185	Target Neighborhood Hits	838	Shared Neighborhood Hits	41
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

ZO2_HUMAN
NC score	0.115446 (rank : 129)	θ value	5.27518 (rank : 154)
Query Neighborhood Hits	185	Target Neighborhood Hits	289	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

MYO9B_MOUSE
NC score	0.115087 (rank : 130)	θ value	0.00175202 (rank : 22)
Query Neighborhood Hits	185	Target Neighborhood Hits	311	Shared Neighborhood Hits	63
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

ROCK1_HUMAN
NC score	0.114541 (rank : 131)	θ value	4.03905 (rank : 138)
Query Neighborhood Hits	185	Target Neighborhood Hits	2000	Shared Neighborhood Hits	71
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

GRK4_MOUSE
NC score	0.114158 (rank : 132)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	185	Target Neighborhood Hits	808	Shared Neighborhood Hits	40
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

ARBK1_HUMAN
NC score	0.114123 (rank : 133)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	185	Target Neighborhood Hits	859	Shared Neighborhood Hits	43
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

GRK4_HUMAN
NC score	0.113888 (rank : 134)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	185	Target Neighborhood Hits	822	Shared Neighborhood Hits	40
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

ARBK1_MOUSE
NC score	0.113657 (rank : 135)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	185	Target Neighborhood Hits	849	Shared Neighborhood Hits	41
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

KS6B2_MOUSE
NC score	0.113584 (rank : 136)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	185	Target Neighborhood Hits	871	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

ARBK2_HUMAN
NC score	0.113485 (rank : 137)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	185	Target Neighborhood Hits	849	Shared Neighborhood Hits	40
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

PZRN3_MOUSE
NC score	0.113279 (rank : 138)	θ value	0.47712 (rank : 78)
Query Neighborhood Hits	185	Target Neighborhood Hits	447	Shared Neighborhood Hits	48
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

RK_HUMAN
NC score	0.113168 (rank : 139)	θ value	θ > 10 (rank : 798)
Query Neighborhood Hits	185	Target Neighborhood Hits	835	Shared Neighborhood Hits	40
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

KAPCB_MOUSE
NC score	0.113167 (rank : 140)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	185	Target Neighborhood Hits	836	Shared Neighborhood Hits	40
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

SYJ2B_HUMAN
NC score	0.113106 (rank : 141)	θ value	θ > 10 (rank : 879)
Query Neighborhood Hits	185	Target Neighborhood Hits	162	Shared Neighborhood Hits	41
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

KAPCB_HUMAN
NC score	0.112923 (rank : 142)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	185	Target Neighborhood Hits	837	Shared Neighborhood Hits	40
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

GRK7_HUMAN
NC score	0.112885 (rank : 143)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	185	Target Neighborhood Hits	820	Shared Neighborhood Hits	40
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

KS6A5_MOUSE
NC score	0.112718 (rank : 144)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	185	Target Neighborhood Hits	854	Shared Neighborhood Hits	40
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

KS6B2_HUMAN
NC score	0.112676 (rank : 145)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	185	Target Neighborhood Hits	858	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

KAPCA_MOUSE
NC score	0.112375 (rank : 146)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	185	Target Neighborhood Hits	836	Shared Neighborhood Hits	40
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KS6B1_HUMAN
NC score	0.112369 (rank : 147)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	185	Target Neighborhood Hits	850	Shared Neighborhood Hits	40
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B1_MOUSE
NC score	0.112366 (rank : 148)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	185	Target Neighborhood Hits	849	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

VAV_HUMAN
NC score	0.112362 (rank : 149)	θ value	2.36792 (rank : 119)
Query Neighborhood Hits	185	Target Neighborhood Hits	452	Shared Neighborhood Hits	57
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

USH1C_MOUSE
NC score	0.112326 (rank : 150)	θ value	θ > 10 (rank : 946)
Query Neighborhood Hits	185	Target Neighborhood Hits	557	Shared Neighborhood Hits	63
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

GRK5_HUMAN
NC score	0.112227 (rank : 151)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	185	Target Neighborhood Hits	819	Shared Neighborhood Hits	40
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK5_MOUSE
NC score	0.112201 (rank : 152)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	185	Target Neighborhood Hits	823	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

KAPCA_HUMAN
NC score	0.112174 (rank : 153)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	185	Target Neighborhood Hits	838	Shared Neighborhood Hits	40
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

PZRN3_HUMAN
NC score	0.111972 (rank : 154)	θ value	0.62314 (rank : 83)
Query Neighborhood Hits	185	Target Neighborhood Hits	461	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

KS6A4_HUMAN
NC score	0.111685 (rank : 155)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	185	Target Neighborhood Hits	868	Shared Neighborhood Hits	40
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

MYO9B_HUMAN
NC score	0.111655 (rank : 156)	θ value	0.0431538 (rank : 39)
Query Neighborhood Hits	185	Target Neighborhood Hits	641	Shared Neighborhood Hits	79
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

KS6A4_MOUSE
NC score	0.111611 (rank : 157)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	185	Target Neighborhood Hits	866	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

GRIP1_MOUSE
NC score	0.111114 (rank : 158)	θ value	1.81305 (rank : 102)
Query Neighborhood Hits	185	Target Neighborhood Hits	241	Shared Neighborhood Hits	47
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

ROCK1_MOUSE
NC score	0.110802 (rank : 159)	θ value	θ > 10 (rank : 800)
Query Neighborhood Hits	185	Target Neighborhood Hits	2126	Shared Neighborhood Hits	71
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

GRK6_MOUSE
NC score	0.110707 (rank : 160)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	185	Target Neighborhood Hits	820	Shared Neighborhood Hits	40
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

GRIP1_HUMAN
NC score	0.110493 (rank : 161)	θ value	1.81305 (rank : 101)
Query Neighborhood Hits	185	Target Neighborhood Hits	231	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

RGAP1_MOUSE
NC score	0.110267 (rank : 162)	θ value	6.88961 (rank : 166)
Query Neighborhood Hits	185	Target Neighborhood Hits	185	Shared Neighborhood Hits	42
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

VAV_MOUSE
NC score	0.110169 (rank : 163)	θ value	1.81305 (rank : 108)
Query Neighborhood Hits	185	Target Neighborhood Hits	430	Shared Neighborhood Hits	54
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

GRK6_HUMAN
NC score	0.109723 (rank : 164)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	185	Target Neighborhood Hits	823	Shared Neighborhood Hits	40
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

ZO2_MOUSE
NC score	0.109605 (rank : 165)	θ value	θ > 10 (rank : 964)
Query Neighborhood Hits	185	Target Neighborhood Hits	296	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

RK_MOUSE
NC score	0.109522 (rank : 166)	θ value	θ > 10 (rank : 799)
Query Neighborhood Hits	185	Target Neighborhood Hits	829	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

CTRO_HUMAN
NC score	0.109502 (rank : 167)	θ value	5.27518 (rank : 143)
Query Neighborhood Hits	185	Target Neighborhood Hits	2092	Shared Neighborhood Hits	71
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

INADL_HUMAN
NC score	0.109395 (rank : 168)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	185	Target Neighborhood Hits	260	Shared Neighborhood Hits	43
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

KAPCG_HUMAN
NC score	0.109146 (rank : 169)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	185	Target Neighborhood Hits	845	Shared Neighborhood Hits	40
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

KS6A5_HUMAN
NC score	0.109122 (rank : 170)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	185	Target Neighborhood Hits	855	Shared Neighborhood Hits	40
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

PRKX_HUMAN
NC score	0.108892 (rank : 171)	θ value	θ > 10 (rank : 749)
Query Neighborhood Hits	185	Target Neighborhood Hits	847	Shared Neighborhood Hits	40
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

PRKX_MOUSE
NC score	0.108866 (rank : 172)	θ value	θ > 10 (rank : 750)
Query Neighborhood Hits	185	Target Neighborhood Hits	846	Shared Neighborhood Hits	40
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

ZO3_HUMAN
NC score	0.108724 (rank : 173)	θ value	θ > 10 (rank : 965)
Query Neighborhood Hits	185	Target Neighborhood Hits	219	Shared Neighborhood Hits	47
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

MASTL_HUMAN
NC score	0.108356 (rank : 174)	θ value	θ > 10 (rank : 569)
Query Neighborhood Hits	185	Target Neighborhood Hits	894	Shared Neighborhood Hits	40
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

PAR3L_HUMAN
NC score	0.108355 (rank : 175)	θ value	θ > 10 (rank : 698)
Query Neighborhood Hits	185	Target Neighborhood Hits	297	Shared Neighborhood Hits	41
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

MASTL_MOUSE
NC score	0.108186 (rank : 176)	θ value	θ > 10 (rank : 570)
Query Neighborhood Hits	185	Target Neighborhood Hits	862	Shared Neighborhood Hits	42
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

RGNEF_MOUSE
NC score	0.108118 (rank : 177)	θ value	2.36792 (rank : 117)
Query Neighborhood Hits	185	Target Neighborhood Hits	641	Shared Neighborhood Hits	72
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

KGP1A_HUMAN
NC score	0.107933 (rank : 178)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	185	Target Neighborhood Hits	901	Shared Neighborhood Hits	41
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_MOUSE
NC score	0.107838 (rank : 179)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	185	Target Neighborhood Hits	922	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_HUMAN
NC score	0.107819 (rank : 180)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	185	Target Neighborhood Hits	921	Shared Neighborhood Hits	42
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

ST32C_HUMAN
NC score	0.106428 (rank : 181)	θ value	θ > 10 (rank : 848)
Query Neighborhood Hits	185	Target Neighborhood Hits	832	Shared Neighborhood Hits	42
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

ST32C_MOUSE
NC score	0.106155 (rank : 182)	θ value	θ > 10 (rank : 849)
Query Neighborhood Hits	185	Target Neighborhood Hits	824	Shared Neighborhood Hits	41
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

RGAP1_HUMAN
NC score	0.105914 (rank : 183)	θ value	6.88961 (rank : 165)
Query Neighborhood Hits	185	Target Neighborhood Hits	189	Shared Neighborhood Hits	45
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

ST32B_HUMAN
NC score	0.105659 (rank : 184)	θ value	θ > 10 (rank : 846)
Query Neighborhood Hits	185	Target Neighborhood Hits	830	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

CTRO_MOUSE
NC score	0.105447 (rank : 185)	θ value	5.27518 (rank : 144)
Query Neighborhood Hits	185	Target Neighborhood Hits	2344	Shared Neighborhood Hits	73
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

F5006_HUMAN
NC score	0.105046 (rank : 186)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	185	Target Neighborhood Hits	794	Shared Neighborhood Hits	40
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

KGP2_MOUSE
NC score	0.104923 (rank : 187)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	185	Target Neighborhood Hits	1029	Shared Neighborhood Hits	43
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

ST32B_MOUSE
NC score	0.104869 (rank : 188)	θ value	θ > 10 (rank : 847)
Query Neighborhood Hits	185	Target Neighborhood Hits	828	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

DGKK_HUMAN
NC score	0.104707 (rank : 189)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	185	Target Neighborhood Hits	378	Shared Neighborhood Hits	42
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

ST32A_HUMAN
NC score	0.104575 (rank : 190)	θ value	θ > 10 (rank : 844)
Query Neighborhood Hits	185	Target Neighborhood Hits	834	Shared Neighborhood Hits	40
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

KGP2_HUMAN
NC score	0.104515 (rank : 191)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	185	Target Neighborhood Hits	1023	Shared Neighborhood Hits	42
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

MPDZ_MOUSE
NC score	0.104451 (rank : 192)	θ value	θ > 10 (rank : 629)
Query Neighborhood Hits	185	Target Neighborhood Hits	298	Shared Neighborhood Hits	47
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

PRKY_HUMAN
NC score	0.103865 (rank : 193)	θ value	θ > 10 (rank : 751)
Query Neighborhood Hits	185	Target Neighborhood Hits	844	Shared Neighborhood Hits	40
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

F5006_MOUSE
NC score	0.103694 (rank : 194)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	185	Target Neighborhood Hits	793	Shared Neighborhood Hits	40
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

MPDZ_HUMAN
NC score	0.103582 (rank : 195)	θ value	θ > 10 (rank : 628)
Query Neighborhood Hits	185	Target Neighborhood Hits	261	Shared Neighborhood Hits	46
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

ST32A_MOUSE
NC score	0.103537 (rank : 196)	θ value	θ > 10 (rank : 845)
Query Neighborhood Hits	185	Target Neighborhood Hits	833	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

VAV2_HUMAN
NC score	0.103301 (rank : 197)	θ value	θ > 10 (rank : 947)
Query Neighborhood Hits	185	Target Neighborhood Hits	453	Shared Neighborhood Hits	56
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

GRIP2_HUMAN
NC score	0.103289 (rank : 198)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	185	Target Neighborhood Hits	256	Shared Neighborhood Hits	45
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

KS6A1_MOUSE
NC score	0.103170 (rank : 199)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	185	Target Neighborhood Hits	850	Shared Neighborhood Hits	40
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A6_HUMAN
NC score	0.102936 (rank : 200)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	185	Target Neighborhood Hits	853	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

PDPK1_MOUSE
NC score	0.102881 (rank : 201)	θ value	θ > 10 (rank : 713)
Query Neighborhood Hits	185	Target Neighborhood Hits	852	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

KS6A1_HUMAN
NC score	0.102737 (rank : 202)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	185	Target Neighborhood Hits	854	Shared Neighborhood Hits	40
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

PDPK1_HUMAN
NC score	0.102735 (rank : 203)	θ value	θ > 10 (rank : 712)
Query Neighborhood Hits	185	Target Neighborhood Hits	851	Shared Neighborhood Hits	41
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

KS6A3_MOUSE
NC score	0.102619 (rank : 204)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	185	Target Neighborhood Hits	860	Shared Neighborhood Hits	40
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

TRIB3_HUMAN
NC score	0.102613 (rank : 205)	θ value	θ > 10 (rank : 911)
Query Neighborhood Hits	185	Target Neighborhood Hits	519	Shared Neighborhood Hits	36
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

KS6A3_HUMAN
NC score	0.102596 (rank : 206)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	185	Target Neighborhood Hits	859	Shared Neighborhood Hits	40
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A2_HUMAN
NC score	0.102031 (rank : 207)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	185	Target Neighborhood Hits	857	Shared Neighborhood Hits	40
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

KS6A2_MOUSE
NC score	0.101488 (rank : 208)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	185	Target Neighborhood Hits	858	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

CSKP_HUMAN
NC score	0.101420 (rank : 209)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	185	Target Neighborhood Hits	1022	Shared Neighborhood Hits	64
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

STK40_HUMAN
NC score	0.101005 (rank : 210)	θ value	θ > 10 (rank : 871)
Query Neighborhood Hits	185	Target Neighborhood Hits	751	Shared Neighborhood Hits	40
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

STK40_MOUSE
NC score	0.100920 (rank : 211)	θ value	θ > 10 (rank : 872)
Query Neighborhood Hits	185	Target Neighborhood Hits	751	Shared Neighborhood Hits	40
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

ARHG2_HUMAN
NC score	0.100709 (rank : 212)	θ value	4.03905 (rank : 131)
Query Neighborhood Hits	185	Target Neighborhood Hits	142	Shared Neighborhood Hits	33
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

CSKP_MOUSE
NC score	0.100413 (rank : 213)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	185	Target Neighborhood Hits	1027	Shared Neighborhood Hits	65
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

VAV2_MOUSE
NC score	0.100392 (rank : 214)	θ value	θ > 10 (rank : 948)
Query Neighborhood Hits	185	Target Neighborhood Hits	456	Shared Neighborhood Hits	53
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

DLG5_HUMAN
NC score	0.100288 (rank : 215)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	185	Target Neighborhood Hits	1088	Shared Neighborhood Hits	68
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

TRIB1_HUMAN
NC score	0.100106 (rank : 216)	θ value	θ > 10 (rank : 907)
Query Neighborhood Hits	185	Target Neighborhood Hits	598	Shared Neighborhood Hits	39
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

TRIB3_MOUSE
NC score	0.099977 (rank : 217)	θ value	θ > 10 (rank : 912)
Query Neighborhood Hits	185	Target Neighborhood Hits	578	Shared Neighborhood Hits	36
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

VAV3_HUMAN
NC score	0.099211 (rank : 218)	θ value	θ > 10 (rank : 949)
Query Neighborhood Hits	185	Target Neighborhood Hits	398	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

GMIP_HUMAN
NC score	0.098804 (rank : 219)	θ value	8.99809 (rank : 179)
Query Neighborhood Hits	185	Target Neighborhood Hits	225	Shared Neighborhood Hits	41
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

TRIB1_MOUSE
NC score	0.098209 (rank : 220)	θ value	θ > 10 (rank : 908)
Query Neighborhood Hits	185	Target Neighborhood Hits	593	Shared Neighborhood Hits	39
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

VAV3_MOUSE
NC score	0.097831 (rank : 221)	θ value	θ > 10 (rank : 950)
Query Neighborhood Hits	185	Target Neighborhood Hits	404	Shared Neighborhood Hits	52
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ULK4_MOUSE
NC score	0.097129 (rank : 222)	θ value	θ > 10 (rank : 943)
Query Neighborhood Hits	185	Target Neighborhood Hits	793	Shared Neighborhood Hits	40
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

ARHG2_MOUSE
NC score	0.096417 (rank : 223)	θ value	4.03905 (rank : 132)
Query Neighborhood Hits	185	Target Neighborhood Hits	120	Shared Neighborhood Hits	33
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

LIN7A_MOUSE
NC score	0.095860 (rank : 224)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	185	Target Neighborhood Hits	193	Shared Neighborhood Hits	45
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

LIN7A_HUMAN
NC score	0.095807 (rank : 225)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	185	Target Neighborhood Hits	193	Shared Neighborhood Hits	45
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

PDZK4_HUMAN
NC score	0.095793 (rank : 226)	θ value	1.06291 (rank : 93)
Query Neighborhood Hits	185	Target Neighborhood Hits	165	Shared Neighborhood Hits	36
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

TRIB2_HUMAN
NC score	0.094865 (rank : 227)	θ value	θ > 10 (rank : 909)
Query Neighborhood Hits	185	Target Neighborhood Hits	657	Shared Neighborhood Hits	39
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB2_MOUSE
NC score	0.094628 (rank : 228)	θ value	θ > 10 (rank : 910)
Query Neighborhood Hits	185	Target Neighborhood Hits	653	Shared Neighborhood Hits	39
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

LIN7B_HUMAN
NC score	0.093946 (rank : 229)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	185	Target Neighborhood Hits	200	Shared Neighborhood Hits	43
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

PDZD2_HUMAN
NC score	0.093845 (rank : 230)	θ value	θ > 10 (rank : 716)
Query Neighborhood Hits	185	Target Neighborhood Hits	772	Shared Neighborhood Hits	53
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

GMIP_MOUSE
NC score	0.093598 (rank : 231)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	185	Target Neighborhood Hits	202	Shared Neighborhood Hits	40
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

LIN7C_HUMAN
NC score	0.093540 (rank : 232)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	185	Target Neighborhood Hits	198	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
NC score	0.093540 (rank : 233)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	185	Target Neighborhood Hits	198	Shared Neighborhood Hits	43
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

PZRN4_HUMAN
NC score	0.093101 (rank : 234)	θ value	θ > 10 (rank : 762)
Query Neighborhood Hits	185	Target Neighborhood Hits	438	Shared Neighborhood Hits	45
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

3BP2_HUMAN
NC score	0.093056 (rank : 235)	θ value	0.00869519 (rank : 31)
Query Neighborhood Hits	185	Target Neighborhood Hits	296	Shared Neighborhood Hits	11
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

LNX2_MOUSE
NC score	0.092993 (rank : 236)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	185	Target Neighborhood Hits	407	Shared Neighborhood Hits	45
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

LIN7B_MOUSE
NC score	0.092817 (rank : 237)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	185	Target Neighborhood Hits	200	Shared Neighborhood Hits	43
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

MAGI1_MOUSE
NC score	0.092766 (rank : 238)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	185	Target Neighborhood Hits	403	Shared Neighborhood Hits	48
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MKNK1_HUMAN
NC score	0.092216 (rank : 239)	θ value	θ > 10 (rank : 605)
Query Neighborhood Hits	185	Target Neighborhood Hits	701	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

MAGI1_HUMAN
NC score	0.092093 (rank : 240)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	185	Target Neighborhood Hits	388	Shared Neighborhood Hits	47
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

DCAK3_HUMAN
NC score	0.091601 (rank : 241)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	185	Target Neighborhood Hits	888	Shared Neighborhood Hits	41
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

SBK1_HUMAN
NC score	0.091359 (rank : 242)	θ value	θ > 10 (rank : 806)
Query Neighborhood Hits	185	Target Neighborhood Hits	828	Shared Neighborhood Hits	40
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

TSSK4_MOUSE
NC score	0.091337 (rank : 243)	θ value	θ > 10 (rank : 921)
Query Neighborhood Hits	185	Target Neighborhood Hits	840	Shared Neighborhood Hits	40
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

PIM2_MOUSE
NC score	0.091299 (rank : 244)	θ value	θ > 10 (rank : 728)
Query Neighborhood Hits	185	Target Neighborhood Hits	809	Shared Neighborhood Hits	40
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

TSSK4_HUMAN
NC score	0.091218 (rank : 245)	θ value	θ > 10 (rank : 920)
Query Neighborhood Hits	185	Target Neighborhood Hits	836	Shared Neighborhood Hits	40
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

KCC4_MOUSE
NC score	0.091133 (rank : 246)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	185	Target Neighborhood Hits	899	Shared Neighborhood Hits	42
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

AURKB_MOUSE
NC score	0.091029 (rank : 247)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	185	Target Neighborhood Hits	858	Shared Neighborhood Hits	40
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

SBK1_MOUSE
NC score	0.090757 (rank : 248)	θ value	θ > 10 (rank : 807)
Query Neighborhood Hits	185	Target Neighborhood Hits	824	Shared Neighborhood Hits	41
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

AURKC_HUMAN
NC score	0.090742 (rank : 249)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	185	Target Neighborhood Hits	847	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

ST17A_HUMAN
NC score	0.090715 (rank : 250)	θ value	θ > 10 (rank : 841)
Query Neighborhood Hits	185	Target Neighborhood Hits	843	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

DCAK3_MOUSE
NC score	0.090698 (rank : 251)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	185	Target Neighborhood Hits	922	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

KCC1D_HUMAN
NC score	0.090457 (rank : 252)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	185	Target Neighborhood Hits	846	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

KCC1D_MOUSE
NC score	0.090457 (rank : 253)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	185	Target Neighborhood Hits	847	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

MKNK1_MOUSE
NC score	0.090363 (rank : 254)	θ value	θ > 10 (rank : 606)
Query Neighborhood Hits	185	Target Neighborhood Hits	811	Shared Neighborhood Hits	40
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

AURKB_HUMAN
NC score	0.090295 (rank : 255)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	185	Target Neighborhood Hits	847	Shared Neighborhood Hits	40
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

M3K14_HUMAN
NC score	0.090282 (rank : 256)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	185	Target Neighborhood Hits	887	Shared Neighborhood Hits	50
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

PIM2_HUMAN
NC score	0.090078 (rank : 257)	θ value	θ > 10 (rank : 727)
Query Neighborhood Hits	185	Target Neighborhood Hits	808	Shared Neighborhood Hits	40
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

KCC4_HUMAN
NC score	0.089875 (rank : 258)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	185	Target Neighborhood Hits	841	Shared Neighborhood Hits	40
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

NUAK2_MOUSE
NC score	0.089740 (rank : 259)	θ value	θ > 10 (rank : 681)
Query Neighborhood Hits	185	Target Neighborhood Hits	878	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

AURKC_MOUSE
NC score	0.089671 (rank : 260)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	185	Target Neighborhood Hits	844	Shared Neighborhood Hits	40
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

PIM3_MOUSE
NC score	0.089609 (rank : 261)	θ value	θ > 10 (rank : 730)
Query Neighborhood Hits	185	Target Neighborhood Hits	783	Shared Neighborhood Hits	40
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

KCC1B_MOUSE
NC score	0.089591 (rank : 262)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	185	Target Neighborhood Hits	842	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

KCC1B_HUMAN
NC score	0.089508 (rank : 263)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	185	Target Neighborhood Hits	842	Shared Neighborhood Hits	40
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

KPSH2_HUMAN
NC score	0.089501 (rank : 264)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	185	Target Neighborhood Hits	822	Shared Neighborhood Hits	40
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

TSSK1_HUMAN
NC score	0.089495 (rank : 265)	θ value	θ > 10 (rank : 914)
Query Neighborhood Hits	185	Target Neighborhood Hits	840	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

ST17B_HUMAN
NC score	0.089423 (rank : 266)	θ value	θ > 10 (rank : 842)
Query Neighborhood Hits	185	Target Neighborhood Hits	833	Shared Neighborhood Hits	40
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

MAGI2_HUMAN
NC score	0.089410 (rank : 267)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	185	Target Neighborhood Hits	373	Shared Neighborhood Hits	54
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

TSSK2_MOUSE
NC score	0.089348 (rank : 268)	θ value	θ > 10 (rank : 917)
Query Neighborhood Hits	185	Target Neighborhood Hits	819	Shared Neighborhood Hits	40
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

KCC1G_MOUSE
NC score	0.089201 (rank : 269)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	185	Target Neighborhood Hits	851	Shared Neighborhood Hits	40
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC1G_HUMAN
NC score	0.088989 (rank : 270)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	185	Target Neighborhood Hits	850	Shared Neighborhood Hits	40
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC1A_HUMAN
NC score	0.088975 (rank : 271)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	185	Target Neighborhood Hits	846	Shared Neighborhood Hits	40
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

LNX2_HUMAN
NC score	0.088900 (rank : 272)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	185	Target Neighborhood Hits	389	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

AAPK2_HUMAN
NC score	0.088895 (rank : 273)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	185	Target Neighborhood Hits	843	Shared Neighborhood Hits	40
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

MAPK5_MOUSE
NC score	0.088869 (rank : 274)	θ value	θ > 10 (rank : 560)
Query Neighborhood Hits	185	Target Neighborhood Hits	799	Shared Neighborhood Hits	40
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

MAGI2_MOUSE
NC score	0.088848 (rank : 275)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	185	Target Neighborhood Hits	370	Shared Neighborhood Hits	52
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

MAPK5_HUMAN
NC score	0.088847 (rank : 276)	θ value	θ > 10 (rank : 559)
Query Neighborhood Hits	185	Target Neighborhood Hits	795	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

KKCC1_MOUSE
NC score	0.088735 (rank : 277)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	185	Target Neighborhood Hits	866	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

AAPK1_MOUSE
NC score	0.088699 (rank : 278)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	185	Target Neighborhood Hits	843	Shared Neighborhood Hits	40
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

KCC1A_MOUSE
NC score	0.088687 (rank : 279)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	185	Target Neighborhood Hits	845	Shared Neighborhood Hits	40
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

M3K14_MOUSE
NC score	0.088666 (rank : 280)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	185	Target Neighborhood Hits	889	Shared Neighborhood Hits	45
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

PIM3_HUMAN
NC score	0.088585 (rank : 281)	θ value	θ > 10 (rank : 729)
Query Neighborhood Hits	185	Target Neighborhood Hits	789	Shared Neighborhood Hits	40
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

PDZ11_HUMAN
NC score	0.088554 (rank : 282)	θ value	θ > 10 (rank : 714)
Query Neighborhood Hits	185	Target Neighborhood Hits	160	Shared Neighborhood Hits	34
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

NIM1_HUMAN
NC score	0.088497 (rank : 283)	θ value	θ > 10 (rank : 672)
Query Neighborhood Hits	185	Target Neighborhood Hits	850	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

HUNK_HUMAN
NC score	0.088433 (rank : 284)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	185	Target Neighborhood Hits	884	Shared Neighborhood Hits	40
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

NIM1_MOUSE
NC score	0.088413 (rank : 285)	θ value	θ > 10 (rank : 673)
Query Neighborhood Hits	185	Target Neighborhood Hits	850	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

HUNK_MOUSE
NC score	0.088381 (rank : 286)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	185	Target Neighborhood Hits	874	Shared Neighborhood Hits	41
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

STK6_HUMAN
NC score	0.088267 (rank : 287)	θ value	θ > 10 (rank : 875)
Query Neighborhood Hits	185	Target Neighborhood Hits	916	Shared Neighborhood Hits	42
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

AAPK1_HUMAN
NC score	0.088228 (rank : 288)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	185	Target Neighborhood Hits	842	Shared Neighborhood Hits	40
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

KPSH1_MOUSE
NC score	0.088166 (rank : 289)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	185	Target Neighborhood Hits	839	Shared Neighborhood Hits	40
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

STK6_MOUSE
NC score	0.088153 (rank : 290)	θ value	θ > 10 (rank : 876)
Query Neighborhood Hits	185	Target Neighborhood Hits	886	Shared Neighborhood Hits	42
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

KPSH1_HUMAN
NC score	0.088134 (rank : 291)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	185	Target Neighborhood Hits	842	Shared Neighborhood Hits	41
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

LNX1_HUMAN
NC score	0.088015 (rank : 292)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	185	Target Neighborhood Hits	379	Shared Neighborhood Hits	38
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

ST17B_MOUSE
NC score	0.087955 (rank : 293)	θ value	θ > 10 (rank : 843)
Query Neighborhood Hits	185	Target Neighborhood Hits	838	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

LNX1_MOUSE
NC score	0.087937 (rank : 294)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	185	Target Neighborhood Hits	377	Shared Neighborhood Hits	43
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

TSSK2_HUMAN
NC score	0.087887 (rank : 295)	θ value	θ > 10 (rank : 916)
Query Neighborhood Hits	185	Target Neighborhood Hits	826	Shared Neighborhood Hits	40
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

PDZ11_MOUSE
NC score	0.087768 (rank : 296)	θ value	θ > 10 (rank : 715)
Query Neighborhood Hits	185	Target Neighborhood Hits	154	Shared Neighborhood Hits	32
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

NUAK2_HUMAN
NC score	0.087706 (rank : 297)	θ value	θ > 10 (rank : 680)
Query Neighborhood Hits	185	Target Neighborhood Hits	874	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

MKNK2_MOUSE
NC score	0.087687 (rank : 298)	θ value	θ > 10 (rank : 608)
Query Neighborhood Hits	185	Target Neighborhood Hits	819	Shared Neighborhood Hits	40
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

KKCC1_HUMAN
NC score	0.087655 (rank : 299)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	185	Target Neighborhood Hits	858	Shared Neighborhood Hits	41
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

MKNK2_HUMAN
NC score	0.087628 (rank : 300)	θ value	θ > 10 (rank : 607)
Query Neighborhood Hits	185	Target Neighborhood Hits	821	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

PLK1_MOUSE
NC score	0.087333 (rank : 301)	θ value	θ > 10 (rank : 740)
Query Neighborhood Hits	185	Target Neighborhood Hits	849	Shared Neighborhood Hits	41
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

CHK2_HUMAN
NC score	0.087202 (rank : 302)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	185	Target Neighborhood Hits	859	Shared Neighborhood Hits	40
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

CHK2_MOUSE
NC score	0.087176 (rank : 303)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	185	Target Neighborhood Hits	860	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

PLK1_HUMAN
NC score	0.087031 (rank : 304)	θ value	θ > 10 (rank : 739)
Query Neighborhood Hits	185	Target Neighborhood Hits	849	Shared Neighborhood Hits	40
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

TRIO_HUMAN
NC score	0.086906 (rank : 305)	θ value	θ > 10 (rank : 913)
Query Neighborhood Hits	185	Target Neighborhood Hits	1580	Shared Neighborhood Hits	63
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

PLK4_HUMAN
NC score	0.086527 (rank : 306)	θ value	θ > 10 (rank : 745)
Query Neighborhood Hits	185	Target Neighborhood Hits	884	Shared Neighborhood Hits	40
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PLK4_MOUSE
NC score	0.086525 (rank : 307)	θ value	θ > 10 (rank : 746)
Query Neighborhood Hits	185	Target Neighborhood Hits	879	Shared Neighborhood Hits	40
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

MYLK2_HUMAN
NC score	0.086427 (rank : 308)	θ value	θ > 10 (rank : 645)
Query Neighborhood Hits	185	Target Neighborhood Hits	920	Shared Neighborhood Hits	42
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

BRSK1_HUMAN
NC score	0.086425 (rank : 309)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	185	Target Neighborhood Hits	942	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

MELK_HUMAN
NC score	0.086405 (rank : 310)	θ value	θ > 10 (rank : 573)
Query Neighborhood Hits	185	Target Neighborhood Hits	847	Shared Neighborhood Hits	40
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

MELK_MOUSE
NC score	0.086372 (rank : 311)	θ value	θ > 10 (rank : 574)
Query Neighborhood Hits	185	Target Neighborhood Hits	860	Shared Neighborhood Hits	41
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

CAMKV_MOUSE
NC score	0.086350 (rank : 312)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	185	Target Neighborhood Hits	848	Shared Neighborhood Hits	44
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

PIM1_MOUSE
NC score	0.086331 (rank : 313)	θ value	θ > 10 (rank : 726)
Query Neighborhood Hits	185	Target Neighborhood Hits	787	Shared Neighborhood Hits	40
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

MARK2_MOUSE
NC score	0.086283 (rank : 314)	θ value	θ > 10 (rank : 564)
Query Neighborhood Hits	185	Target Neighborhood Hits	1018	Shared Neighborhood Hits	46
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

KKCC2_MOUSE
NC score	0.086122 (rank : 315)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	185	Target Neighborhood Hits	855	Shared Neighborhood Hits	40
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_HUMAN
NC score	0.086042 (rank : 316)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	185	Target Neighborhood Hits	852	Shared Neighborhood Hits	40
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

IWS1_MOUSE
NC score	0.086024 (rank : 317)	θ value	0.00102713 (rank : 12)
Query Neighborhood Hits	185	Target Neighborhood Hits	1258	Shared Neighborhood Hits	34
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

TSSK6_HUMAN
NC score	0.085980 (rank : 318)	θ value	θ > 10 (rank : 922)
Query Neighborhood Hits	185	Target Neighborhood Hits	824	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

NUAK1_MOUSE
NC score	0.085947 (rank : 319)	θ value	θ > 10 (rank : 679)
Query Neighborhood Hits	185	Target Neighborhood Hits	881	Shared Neighborhood Hits	42
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

NUAK1_HUMAN
NC score	0.085934 (rank : 320)	θ value	θ > 10 (rank : 678)
Query Neighborhood Hits	185	Target Neighborhood Hits	874	Shared Neighborhood Hits	42
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

STK33_HUMAN
NC score	0.085876 (rank : 321)	θ value	θ > 10 (rank : 861)
Query Neighborhood Hits	185	Target Neighborhood Hits	879	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

MAPK3_HUMAN
NC score	0.085719 (rank : 322)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	185	Target Neighborhood Hits	807	Shared Neighborhood Hits	40
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

MARK2_HUMAN
NC score	0.085692 (rank : 323)	θ value	θ > 10 (rank : 563)
Query Neighborhood Hits	185	Target Neighborhood Hits	1056	Shared Neighborhood Hits	46
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

PASK_MOUSE
NC score	0.085613 (rank : 324)	θ value	θ > 10 (rank : 700)
Query Neighborhood Hits	185	Target Neighborhood Hits	867	Shared Neighborhood Hits	40
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

MARK3_HUMAN
NC score	0.085529 (rank : 325)	θ value	θ > 10 (rank : 565)
Query Neighborhood Hits	185	Target Neighborhood Hits	893	Shared Neighborhood Hits	43
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

MAPK3_MOUSE
NC score	0.085443 (rank : 326)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	185	Target Neighborhood Hits	811	Shared Neighborhood Hits	40
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

SN1L2_MOUSE
NC score	0.085426 (rank : 327)	θ value	θ > 10 (rank : 823)
Query Neighborhood Hits	185	Target Neighborhood Hits	944	Shared Neighborhood Hits	54
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

MARK4_HUMAN
NC score	0.085356 (rank : 328)	θ value	θ > 10 (rank : 567)
Query Neighborhood Hits	185	Target Neighborhood Hits	886	Shared Neighborhood Hits	41
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

CAMKV_HUMAN
NC score	0.085339 (rank : 329)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	185	Target Neighborhood Hits	1084	Shared Neighborhood Hits	44
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

MARK4_MOUSE
NC score	0.085254 (rank : 330)	θ value	θ > 10 (rank : 568)
Query Neighborhood Hits	185	Target Neighborhood Hits	898	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

DCAK2_HUMAN
NC score	0.085170 (rank : 331)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	185	Target Neighborhood Hits	862	Shared Neighborhood Hits	40
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

BRSK2_HUMAN
NC score	0.085170 (rank : 332)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	185	Target Neighborhood Hits	897	Shared Neighborhood Hits	42
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

SN1L2_HUMAN
NC score	0.085072 (rank : 333)	θ value	θ > 10 (rank : 822)
Query Neighborhood Hits	185	Target Neighborhood Hits	964	Shared Neighborhood Hits	52
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

MARK1_MOUSE
NC score	0.085064 (rank : 334)	θ value	θ > 10 (rank : 562)
Query Neighborhood Hits	185	Target Neighborhood Hits	886	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

MAPK2_HUMAN
NC score	0.085019 (rank : 335)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	185	Target Neighborhood Hits	844	Shared Neighborhood Hits	41
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MARK3_MOUSE
NC score	0.085013 (rank : 336)	θ value	θ > 10 (rank : 566)
Query Neighborhood Hits	185	Target Neighborhood Hits	919	Shared Neighborhood Hits	42
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

PASK_HUMAN
NC score	0.084959 (rank : 337)	θ value	θ > 10 (rank : 699)
Query Neighborhood Hits	185	Target Neighborhood Hits	857	Shared Neighborhood Hits	41
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

MAPK2_MOUSE
NC score	0.084768 (rank : 338)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	185	Target Neighborhood Hits	831	Shared Neighborhood Hits	41
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MARK1_HUMAN
NC score	0.084735 (rank : 339)	θ value	θ > 10 (rank : 561)
Query Neighborhood Hits	185	Target Neighborhood Hits	887	Shared Neighborhood Hits	40
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

K0999_MOUSE
NC score	0.084593 (rank : 340)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	185	Target Neighborhood Hits	931	Shared Neighborhood Hits	44
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

TSSK6_MOUSE
NC score	0.084567 (rank : 341)	θ value	θ > 10 (rank : 923)
Query Neighborhood Hits	185	Target Neighborhood Hits	824	Shared Neighborhood Hits	40
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

SN1L1_HUMAN
NC score	0.084555 (rank : 342)	θ value	θ > 10 (rank : 820)
Query Neighborhood Hits	185	Target Neighborhood Hits	911	Shared Neighborhood Hits	43
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

PINK1_MOUSE
NC score	0.084509 (rank : 343)	θ value	θ > 10 (rank : 732)
Query Neighborhood Hits	185	Target Neighborhood Hits	726	Shared Neighborhood Hits	40
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

K0999_HUMAN
NC score	0.084498 (rank : 344)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	185	Target Neighborhood Hits	899	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

PHKG1_MOUSE
NC score	0.084490 (rank : 345)	θ value	θ > 10 (rank : 722)
Query Neighborhood Hits	185	Target Neighborhood Hits	840	Shared Neighborhood Hits	40
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

DCAK2_MOUSE
NC score	0.084473 (rank : 346)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	185	Target Neighborhood Hits	858	Shared Neighborhood Hits	40
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

TSSK1_MOUSE
NC score	0.084424 (rank : 347)	θ value	θ > 10 (rank : 915)
Query Neighborhood Hits	185	Target Neighborhood Hits	835	Shared Neighborhood Hits	40
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

PLK2_HUMAN
NC score	0.084369 (rank : 348)	θ value	θ > 10 (rank : 741)
Query Neighborhood Hits	185	Target Neighborhood Hits	854	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PIM1_HUMAN
NC score	0.084270 (rank : 349)	θ value	θ > 10 (rank : 725)
Query Neighborhood Hits	185	Target Neighborhood Hits	797	Shared Neighborhood Hits	40
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

PLK2_MOUSE
NC score	0.084027 (rank : 350)	θ value	θ > 10 (rank : 742)
Query Neighborhood Hits	185	Target Neighborhood Hits	849	Shared Neighborhood Hits	40
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

DAPK2_MOUSE
NC score	0.083883 (rank : 351)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	185	Target Neighborhood Hits	834	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

GRASP_MOUSE
NC score	0.083761 (rank : 352)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	185	Target Neighborhood Hits	131	Shared Neighborhood Hits	37
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

GRASP_HUMAN
NC score	0.083729 (rank : 353)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	185	Target Neighborhood Hits	147	Shared Neighborhood Hits	35
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

KCC2G_HUMAN
NC score	0.083707 (rank : 354)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	185	Target Neighborhood Hits	841	Shared Neighborhood Hits	41
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

PMYT1_HUMAN
NC score	0.083685 (rank : 355)	θ value	θ > 10 (rank : 747)
Query Neighborhood Hits	185	Target Neighborhood Hits	814	Shared Neighborhood Hits	41
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

KCC2G_MOUSE
NC score	0.083656 (rank : 356)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	185	Target Neighborhood Hits	838	Shared Neighborhood Hits	40
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2D_HUMAN
NC score	0.083557 (rank : 357)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	185	Target Neighborhood Hits	830	Shared Neighborhood Hits	40
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

ULK3_MOUSE
NC score	0.083493 (rank : 358)	θ value	θ > 10 (rank : 942)
Query Neighborhood Hits	185	Target Neighborhood Hits	872	Shared Neighborhood Hits	41
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

PHKG1_HUMAN
NC score	0.083382 (rank : 359)	θ value	θ > 10 (rank : 721)
Query Neighborhood Hits	185	Target Neighborhood Hits	838	Shared Neighborhood Hits	40
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

PDK1L_HUMAN
NC score	0.083372 (rank : 360)	θ value	θ > 10 (rank : 709)
Query Neighborhood Hits	185	Target Neighborhood Hits	821	Shared Neighborhood Hits	40
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

NEK3_MOUSE
NC score	0.083349 (rank : 361)	θ value	θ > 10 (rank : 661)
Query Neighborhood Hits	185	Target Neighborhood Hits	854	Shared Neighborhood Hits	40
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

STK11_HUMAN
NC score	0.083326 (rank : 362)	θ value	θ > 10 (rank : 854)
Query Neighborhood Hits	185	Target Neighborhood Hits	831	Shared Neighborhood Hits	40
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

KCC2A_MOUSE
NC score	0.083272 (rank : 363)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	185	Target Neighborhood Hits	829	Shared Neighborhood Hits	40
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

DCAK1_HUMAN
NC score	0.083254 (rank : 364)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	185	Target Neighborhood Hits	877	Shared Neighborhood Hits	43
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

RIPK5_MOUSE
NC score	0.083191 (rank : 365)	θ value	θ > 10 (rank : 797)
Query Neighborhood Hits	185	Target Neighborhood Hits	874	Shared Neighborhood Hits	40
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

KCC2A_HUMAN
NC score	0.083150 (rank : 366)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	185	Target Neighborhood Hits	830	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

SNRK_HUMAN
NC score	0.083145 (rank : 367)	θ value	θ > 10 (rank : 824)
Query Neighborhood Hits	185	Target Neighborhood Hits	855	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

PDK1L_MOUSE
NC score	0.083101 (rank : 368)	θ value	θ > 10 (rank : 710)
Query Neighborhood Hits	185	Target Neighborhood Hits	821	Shared Neighborhood Hits	40
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

KCC2B_HUMAN
NC score	0.083075 (rank : 369)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	185	Target Neighborhood Hits	866	Shared Neighborhood Hits	42
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

RIPK5_HUMAN
NC score	0.083027 (rank : 370)	θ value	θ > 10 (rank : 796)
Query Neighborhood Hits	185	Target Neighborhood Hits	864	Shared Neighborhood Hits	40
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

ULK3_HUMAN
NC score	0.082985 (rank : 371)	θ value	θ > 10 (rank : 941)
Query Neighborhood Hits	185	Target Neighborhood Hits	830	Shared Neighborhood Hits	40
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

ULK2_MOUSE
NC score	0.082916 (rank : 372)	θ value	θ > 10 (rank : 940)
Query Neighborhood Hits	185	Target Neighborhood Hits	943	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

SN1L1_MOUSE
NC score	0.082802 (rank : 373)	θ value	θ > 10 (rank : 821)
Query Neighborhood Hits	185	Target Neighborhood Hits	895	Shared Neighborhood Hits	40
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

ULK2_HUMAN
NC score	0.082783 (rank : 374)	θ value	θ > 10 (rank : 939)
Query Neighborhood Hits	185	Target Neighborhood Hits	979	Shared Neighborhood Hits	43
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

DCAK1_MOUSE
NC score	0.082757 (rank : 375)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	185	Target Neighborhood Hits	867	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

PLK3_HUMAN
NC score	0.082753 (rank : 376)	θ value	θ > 10 (rank : 743)
Query Neighborhood Hits	185	Target Neighborhood Hits	865	Shared Neighborhood Hits	40
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

DAPK2_HUMAN
NC score	0.082752 (rank : 377)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	185	Target Neighborhood Hits	832	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

PHKG2_MOUSE
NC score	0.082736 (rank : 378)	θ value	θ > 10 (rank : 724)
Query Neighborhood Hits	185	Target Neighborhood Hits	841	Shared Neighborhood Hits	40
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

PHKG2_HUMAN
NC score	0.082640 (rank : 379)	θ value	θ > 10 (rank : 723)
Query Neighborhood Hits	185	Target Neighborhood Hits	839	Shared Neighborhood Hits	40
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

PMYT1_MOUSE
NC score	0.082592 (rank : 380)	θ value	θ > 10 (rank : 748)
Query Neighborhood Hits	185	Target Neighborhood Hits	910	Shared Neighborhood Hits	41
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

KCC2B_MOUSE
NC score	0.082529 (rank : 381)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	185	Target Neighborhood Hits	841	Shared Neighborhood Hits	40
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

STK36_HUMAN
NC score	0.082446 (rank : 382)	θ value	θ > 10 (rank : 863)
Query Neighborhood Hits	185	Target Neighborhood Hits	896	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

PDZK4_MOUSE
NC score	0.082442 (rank : 383)	θ value	θ > 10 (rank : 718)
Query Neighborhood Hits	185	Target Neighborhood Hits	165	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

STK36_MOUSE
NC score	0.082207 (rank : 384)	θ value	θ > 10 (rank : 864)
Query Neighborhood Hits	185	Target Neighborhood Hits	877	Shared Neighborhood Hits	41
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

PLK3_MOUSE
NC score	0.082072 (rank : 385)	θ value	θ > 10 (rank : 744)
Query Neighborhood Hits	185	Target Neighborhood Hits	863	Shared Neighborhood Hits	40
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

ULK1_MOUSE
NC score	0.082064 (rank : 386)	θ value	θ > 10 (rank : 938)
Query Neighborhood Hits	185	Target Neighborhood Hits	1214	Shared Neighborhood Hits	49
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

SNRK_MOUSE
NC score	0.082039 (rank : 387)	θ value	θ > 10 (rank : 825)
Query Neighborhood Hits	185	Target Neighborhood Hits	849	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

DUET_HUMAN
NC score	0.081879 (rank : 388)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	185	Target Neighborhood Hits	1220	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

NEK3_HUMAN
NC score	0.081859 (rank : 389)	θ value	θ > 10 (rank : 660)
Query Neighborhood Hits	185	Target Neighborhood Hits	865	Shared Neighborhood Hits	40
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

TSSK3_MOUSE
NC score	0.081748 (rank : 390)	θ value	θ > 10 (rank : 919)
Query Neighborhood Hits	185	Target Neighborhood Hits	806	Shared Neighborhood Hits	40
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

TSSK3_HUMAN
NC score	0.081632 (rank : 391)	θ value	θ > 10 (rank : 918)
Query Neighborhood Hits	185	Target Neighborhood Hits	806	Shared Neighborhood Hits	40
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

ULK1_HUMAN
NC score	0.081620 (rank : 392)	θ value	θ > 10 (rank : 937)
Query Neighborhood Hits	185	Target Neighborhood Hits	1121	Shared Neighborhood Hits	45
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

AFAD_HUMAN
NC score	0.081463 (rank : 393)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	185	Target Neighborhood Hits	689	Shared Neighborhood Hits	69
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

DAPK3_HUMAN
NC score	0.081459 (rank : 394)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	185	Target Neighborhood Hits	945	Shared Neighborhood Hits	46
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

RIMS1_HUMAN
NC score	0.080970 (rank : 395)	θ value	θ > 10 (rank : 786)
Query Neighborhood Hits	185	Target Neighborhood Hits	437	Shared Neighborhood Hits	51
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

TBK1_MOUSE
NC score	0.080897 (rank : 396)	θ value	θ > 10 (rank : 888)
Query Neighborhood Hits	185	Target Neighborhood Hits	893	Shared Neighborhood Hits	45
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

DAPK3_MOUSE
NC score	0.080636 (rank : 397)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	185	Target Neighborhood Hits	843	Shared Neighborhood Hits	41
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

TBK1_HUMAN
NC score	0.080093 (rank : 398)	θ value	θ > 10 (rank : 887)
Query Neighborhood Hits	185	Target Neighborhood Hits	861	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

RGS3_HUMAN
NC score	0.079941 (rank : 399)	θ value	8.99809 (rank : 184)
Query Neighborhood Hits	185	Target Neighborhood Hits	1375	Shared Neighborhood Hits	64
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

PSCBP_MOUSE
NC score	0.079869 (rank : 400)	θ value	θ > 10 (rank : 755)
Query Neighborhood Hits	185	Target Neighborhood Hits	118	Shared Neighborhood Hits	33
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

PAK4_MOUSE
NC score	0.079772 (rank : 401)	θ value	θ > 10 (rank : 694)
Query Neighborhood Hits	185	Target Neighborhood Hits	1098	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

E2AK2_MOUSE
NC score	0.079582 (rank : 402)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	185	Target Neighborhood Hits	864	Shared Neighborhood Hits	40
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

BRAF1_HUMAN
NC score	0.079502 (rank : 403)	θ value	3.0926 (rank : 122)
Query Neighborhood Hits	185	Target Neighborhood Hits	883	Shared Neighborhood Hits	64
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

NEK11_HUMAN
NC score	0.079250 (rank : 404)	θ value	θ > 10 (rank : 654)
Query Neighborhood Hits	185	Target Neighborhood Hits	1043	Shared Neighborhood Hits	49
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

PAK4_HUMAN
NC score	0.079193 (rank : 405)	θ value	θ > 10 (rank : 693)
Query Neighborhood Hits	185	Target Neighborhood Hits	924	Shared Neighborhood Hits	42
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PAK7_HUMAN
NC score	0.079181 (rank : 406)	θ value	θ > 10 (rank : 696)
Query Neighborhood Hits	185	Target Neighborhood Hits	875	Shared Neighborhood Hits	40
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

NEK4_HUMAN
NC score	0.079038 (rank : 407)	θ value	θ > 10 (rank : 662)
Query Neighborhood Hits	185	Target Neighborhood Hits	883	Shared Neighborhood Hits	40
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

MP2K1_HUMAN
NC score	0.079036 (rank : 408)	θ value	θ > 10 (rank : 615)
Query Neighborhood Hits	185	Target Neighborhood Hits	826	Shared Neighborhood Hits	40
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_MOUSE
NC score	0.078952 (rank : 409)	θ value	θ > 10 (rank : 616)
Query Neighborhood Hits	185	Target Neighborhood Hits	826	Shared Neighborhood Hits	40
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

M3K6_HUMAN
NC score	0.078930 (rank : 410)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	185	Target Neighborhood Hits	889	Shared Neighborhood Hits	43
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

NEK1_MOUSE
NC score	0.078900 (rank : 411)	θ value	θ > 10 (rank : 657)
Query Neighborhood Hits	185	Target Neighborhood Hits	1311	Shared Neighborhood Hits	53
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

MP2K7_HUMAN
NC score	0.078800 (rank : 412)	θ value	θ > 10 (rank : 627)
Query Neighborhood Hits	185	Target Neighborhood Hits	833	Shared Neighborhood Hits	40
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

MP2K2_HUMAN
NC score	0.078777 (rank : 413)	θ value	θ > 10 (rank : 617)
Query Neighborhood Hits	185	Target Neighborhood Hits	830	Shared Neighborhood Hits	40
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

PAK7_MOUSE
NC score	0.078709 (rank : 414)	θ value	θ > 10 (rank : 697)
Query Neighborhood Hits	185	Target Neighborhood Hits	875	Shared Neighborhood Hits	41
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

CHK1_HUMAN
NC score	0.078707 (rank : 415)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	185	Target Neighborhood Hits	843	Shared Neighborhood Hits	40
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

RAF1_MOUSE
NC score	0.078608 (rank : 416)	θ value	θ > 10 (rank : 764)
Query Neighborhood Hits	185	Target Neighborhood Hits	886	Shared Neighborhood Hits	63
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

STK35_HUMAN
NC score	0.078470 (rank : 417)	θ value	θ > 10 (rank : 862)
Query Neighborhood Hits	185	Target Neighborhood Hits	825	Shared Neighborhood Hits	40
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

MPP4_HUMAN
NC score	0.078467 (rank : 418)	θ value	θ > 10 (rank : 634)
Query Neighborhood Hits	185	Target Neighborhood Hits	205	Shared Neighborhood Hits	43
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

NEK4_MOUSE
NC score	0.078429 (rank : 419)	θ value	θ > 10 (rank : 663)
Query Neighborhood Hits	185	Target Neighborhood Hits	899	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

CHK1_MOUSE
NC score	0.078294 (rank : 420)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	185	Target Neighborhood Hits	839	Shared Neighborhood Hits	40
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

RAF1_HUMAN
NC score	0.078269 (rank : 421)	θ value	θ > 10 (rank : 763)
Query Neighborhood Hits	185	Target Neighborhood Hits	886	Shared Neighborhood Hits	63
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

MP2K2_MOUSE
NC score	0.078226 (rank : 422)	θ value	θ > 10 (rank : 618)
Query Neighborhood Hits	185	Target Neighborhood Hits	828	Shared Neighborhood Hits	40
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

ARAF_MOUSE
NC score	0.078193 (rank : 423)	θ value	6.88961 (rank : 155)
Query Neighborhood Hits	185	Target Neighborhood Hits	874	Shared Neighborhood Hits	63
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

DYR1A_HUMAN
NC score	0.077971 (rank : 424)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	185	Target Neighborhood Hits	764	Shared Neighborhood Hits	40
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

PAK6_HUMAN
NC score	0.077966 (rank : 425)	θ value	θ > 10 (rank : 695)
Query Neighborhood Hits	185	Target Neighborhood Hits	915	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

DYR1A_MOUSE
NC score	0.077959 (rank : 426)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	185	Target Neighborhood Hits	762	Shared Neighborhood Hits	40
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

NEK11_MOUSE
NC score	0.077922 (rank : 427)	θ value	θ > 10 (rank : 655)
Query Neighborhood Hits	185	Target Neighborhood Hits	875	Shared Neighborhood Hits	41
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

DYR1B_HUMAN
NC score	0.077769 (rank : 428)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	185	Target Neighborhood Hits	831	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

NEK2_MOUSE
NC score	0.077762 (rank : 429)	θ value	θ > 10 (rank : 659)
Query Neighborhood Hits	185	Target Neighborhood Hits	876	Shared Neighborhood Hits	44
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

MYLK_MOUSE
NC score	0.077401 (rank : 430)	θ value	θ > 10 (rank : 647)
Query Neighborhood Hits	185	Target Neighborhood Hits	1489	Shared Neighborhood Hits	51
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

IKKB_HUMAN
NC score	0.077389 (rank : 431)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	185	Target Neighborhood Hits	980	Shared Neighborhood Hits	44
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

NEK9_MOUSE
NC score	0.077369 (rank : 432)	θ value	θ > 10 (rank : 671)
Query Neighborhood Hits	185	Target Neighborhood Hits	890	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

IKKA_HUMAN
NC score	0.077300 (rank : 433)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	185	Target Neighborhood Hits	863	Shared Neighborhood Hits	40
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKB_MOUSE
NC score	0.077298 (rank : 434)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	185	Target Neighborhood Hits	984	Shared Neighborhood Hits	45
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKA_MOUSE
NC score	0.077277 (rank : 435)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	185	Target Neighborhood Hits	867	Shared Neighborhood Hits	41
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

SCYL2_MOUSE
NC score	0.077242 (rank : 436)	θ value	θ > 10 (rank : 809)
Query Neighborhood Hits	185	Target Neighborhood Hits	603	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

NEK1_HUMAN
NC score	0.077214 (rank : 437)	θ value	θ > 10 (rank : 656)
Query Neighborhood Hits	185	Target Neighborhood Hits	1129	Shared Neighborhood Hits	47
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

M3K15_HUMAN
NC score	0.077171 (rank : 438)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	185	Target Neighborhood Hits	914	Shared Neighborhood Hits	44
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

MP2K5_MOUSE
NC score	0.077047 (rank : 439)	θ value	θ > 10 (rank : 624)
Query Neighborhood Hits	185	Target Neighborhood Hits	840	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

M4K3_HUMAN
NC score	0.076928 (rank : 440)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	185	Target Neighborhood Hits	857	Shared Neighborhood Hits	41
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

GOPC_MOUSE
NC score	0.076876 (rank : 441)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	185	Target Neighborhood Hits	323	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

M3K5_HUMAN
NC score	0.076461 (rank : 442)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	185	Target Neighborhood Hits	868	Shared Neighborhood Hits	41
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K5_MOUSE
NC score	0.076453 (rank : 443)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	185	Target Neighborhood Hits	867	Shared Neighborhood Hits	40
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

PINK1_HUMAN
NC score	0.076452 (rank : 444)	θ value	θ > 10 (rank : 731)
Query Neighborhood Hits	185	Target Neighborhood Hits	741	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

SPEG_HUMAN
NC score	0.076419 (rank : 445)	θ value	θ > 10 (rank : 836)
Query Neighborhood Hits	185	Target Neighborhood Hits	1762	Shared Neighborhood Hits	65
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

PAK2_HUMAN
NC score	0.076409 (rank : 446)	θ value	θ > 10 (rank : 689)
Query Neighborhood Hits	185	Target Neighborhood Hits	862	Shared Neighborhood Hits	41
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

NEK9_HUMAN
NC score	0.076403 (rank : 447)	θ value	θ > 10 (rank : 670)
Query Neighborhood Hits	185	Target Neighborhood Hits	900	Shared Neighborhood Hits	42
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

MYLK_HUMAN
NC score	0.076361 (rank : 448)	θ value	θ > 10 (rank : 646)
Query Neighborhood Hits	185	Target Neighborhood Hits	1328	Shared Neighborhood Hits	44
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

NEK2_HUMAN
NC score	0.076339 (rank : 449)	θ value	θ > 10 (rank : 658)
Query Neighborhood Hits	185	Target Neighborhood Hits	908	Shared Neighborhood Hits	45
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

PAK2_MOUSE
NC score	0.076303 (rank : 450)	θ value	θ > 10 (rank : 690)
Query Neighborhood Hits	185	Target Neighborhood Hits	858	Shared Neighborhood Hits	40
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

DYR1B_MOUSE
NC score	0.076263 (rank : 451)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	185	Target Neighborhood Hits	799	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

MYO3B_HUMAN
NC score	0.076164 (rank : 452)	θ value	θ > 10 (rank : 650)
Query Neighborhood Hits	185	Target Neighborhood Hits	923	Shared Neighborhood Hits	44
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

RHPN1_MOUSE
NC score	0.076098 (rank : 453)	θ value	θ > 10 (rank : 785)
Query Neighborhood Hits	185	Target Neighborhood Hits	154	Shared Neighborhood Hits	39
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

WNK1_HUMAN
NC score	0.076083 (rank : 454)	θ value	θ > 10 (rank : 955)
Query Neighborhood Hits	185	Target Neighborhood Hits	1158	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

PAK3_HUMAN
NC score	0.076077 (rank : 455)	θ value	θ > 10 (rank : 691)
Query Neighborhood Hits	185	Target Neighborhood Hits	887	Shared Neighborhood Hits	43
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PAK3_MOUSE
NC score	0.075979 (rank : 456)	θ value	θ > 10 (rank : 692)
Query Neighborhood Hits	185	Target Neighborhood Hits	874	Shared Neighborhood Hits	41
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

CDKL5_HUMAN
NC score	0.075970 (rank : 457)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	185	Target Neighborhood Hits	967	Shared Neighborhood Hits	42
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

SCYL2_HUMAN
NC score	0.075935 (rank : 458)	θ value	θ > 10 (rank : 808)
Query Neighborhood Hits	185	Target Neighborhood Hits	632	Shared Neighborhood Hits	41
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

ARAF_HUMAN
NC score	0.075931 (rank : 459)	θ value	8.99809 (rank : 172)
Query Neighborhood Hits	185	Target Neighborhood Hits	924	Shared Neighborhood Hits	62
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

PAK1_MOUSE
NC score	0.075879 (rank : 460)	θ value	θ > 10 (rank : 688)
Query Neighborhood Hits	185	Target Neighborhood Hits	878	Shared Neighborhood Hits	40
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

DYRK2_HUMAN
NC score	0.075839 (rank : 461)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	185	Target Neighborhood Hits	799	Shared Neighborhood Hits	40
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

PAK1_HUMAN
NC score	0.075768 (rank : 462)	θ value	θ > 10 (rank : 687)
Query Neighborhood Hits	185	Target Neighborhood Hits	873	Shared Neighborhood Hits	40
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

GOPC_HUMAN
NC score	0.075739 (rank : 463)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	185	Target Neighborhood Hits	377	Shared Neighborhood Hits	45
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

RIPK3_MOUSE
NC score	0.075722 (rank : 464)	θ value	θ > 10 (rank : 794)
Query Neighborhood Hits	185	Target Neighborhood Hits	867	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

NEK8_HUMAN
NC score	0.075685 (rank : 465)	θ value	θ > 10 (rank : 668)
Query Neighborhood Hits	185	Target Neighborhood Hits	872	Shared Neighborhood Hits	42
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

M3K11_HUMAN
NC score	0.075616 (rank : 466)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	185	Target Neighborhood Hits	1136	Shared Neighborhood Hits	56
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

NEK8_MOUSE
NC score	0.075493 (rank : 467)	θ value	θ > 10 (rank : 669)
Query Neighborhood Hits	185	Target Neighborhood Hits	872	Shared Neighborhood Hits	42
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

MP2K5_HUMAN
NC score	0.075417 (rank : 468)	θ value	θ > 10 (rank : 623)
Query Neighborhood Hits	185	Target Neighborhood Hits	837	Shared Neighborhood Hits	40
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

WNK2_HUMAN
NC score	0.075416 (rank : 469)	θ value	θ > 10 (rank : 957)
Query Neighborhood Hits	185	Target Neighborhood Hits	1407	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

M3K3_MOUSE
NC score	0.075364 (rank : 470)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	185	Target Neighborhood Hits	876	Shared Neighborhood Hits	40
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

HIPK2_MOUSE
NC score	0.075311 (rank : 471)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	185	Target Neighborhood Hits	871	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

M3K2_HUMAN
NC score	0.075255 (rank : 472)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	185	Target Neighborhood Hits	849	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

K1849_HUMAN
NC score	0.075207 (rank : 473)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	185	Target Neighborhood Hits	220	Shared Neighborhood Hits	44
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

M3K3_HUMAN
NC score	0.075202 (rank : 474)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	185	Target Neighborhood Hits	885	Shared Neighborhood Hits	40
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M4K2_HUMAN
NC score	0.075178 (rank : 475)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	185	Target Neighborhood Hits	850	Shared Neighborhood Hits	41
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

MPP5_HUMAN
NC score	0.075137 (rank : 476)	θ value	θ > 10 (rank : 636)
Query Neighborhood Hits	185	Target Neighborhood Hits	231	Shared Neighborhood Hits	33
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

HIPK2_HUMAN
NC score	0.075132 (rank : 477)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	185	Target Neighborhood Hits	845	Shared Neighborhood Hits	43
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

M4K2_MOUSE
NC score	0.075065 (rank : 478)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	185	Target Neighborhood Hits	843	Shared Neighborhood Hits	40
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

PCLO_MOUSE
NC score	0.075044 (rank : 479)	θ value	θ > 10 (rank : 702)
Query Neighborhood Hits	185	Target Neighborhood Hits	2275	Shared Neighborhood Hits	83
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

M3K1_MOUSE
NC score	0.074990 (rank : 480)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	185	Target Neighborhood Hits	952	Shared Neighborhood Hits	44
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

MPP5_MOUSE
NC score	0.074844 (rank : 481)	θ value	θ > 10 (rank : 637)
Query Neighborhood Hits	185	Target Neighborhood Hits	226	Shared Neighborhood Hits	32
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

WNK1_MOUSE
NC score	0.074799 (rank : 482)	θ value	θ > 10 (rank : 956)
Query Neighborhood Hits	185	Target Neighborhood Hits	1179	Shared Neighborhood Hits	52
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

WNK4_HUMAN
NC score	0.074799 (rank : 483)	θ value	θ > 10 (rank : 959)
Query Neighborhood Hits	185	Target Neighborhood Hits	1043	Shared Neighborhood Hits	53
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

SLK_MOUSE
NC score	0.074773 (rank : 484)	θ value	θ > 10 (rank : 819)
Query Neighborhood Hits	185	Target Neighborhood Hits	1798	Shared Neighborhood Hits	71
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

IKKE_HUMAN
NC score	0.074747 (rank : 485)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	185	Target Neighborhood Hits	837	Shared Neighborhood Hits	41
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

MP2K3_MOUSE
NC score	0.074725 (rank : 486)	θ value	θ > 10 (rank : 620)
Query Neighborhood Hits	185	Target Neighborhood Hits	826	Shared Neighborhood Hits	40
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

TTK_MOUSE
NC score	0.074674 (rank : 487)	θ value	θ > 10 (rank : 926)
Query Neighborhood Hits	185	Target Neighborhood Hits	803	Shared Neighborhood Hits	39
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

IWS1_HUMAN
NC score	0.074625 (rank : 488)	θ value	0.0736092 (rank : 46)
Query Neighborhood Hits	185	Target Neighborhood Hits	1241	Shared Neighborhood Hits	33
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

WNK4_MOUSE
NC score	0.074524 (rank : 489)	θ value	θ > 10 (rank : 960)
Query Neighborhood Hits	185	Target Neighborhood Hits	961	Shared Neighborhood Hits	51
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

SHAN2_HUMAN
NC score	0.074501 (rank : 490)	θ value	θ > 10 (rank : 816)
Query Neighborhood Hits	185	Target Neighborhood Hits	346	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

LAP4_HUMAN
NC score	0.074364 (rank : 491)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	185	Target Neighborhood Hits	608	Shared Neighborhood Hits	49
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

STK10_MOUSE
NC score	0.074272 (rank : 492)	θ value	θ > 10 (rank : 853)
Query Neighborhood Hits	185	Target Neighborhood Hits	2132	Shared Neighborhood Hits	69
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

SPEG_MOUSE
NC score	0.074187 (rank : 493)	θ value	θ > 10 (rank : 837)
Query Neighborhood Hits	185	Target Neighborhood Hits	1959	Shared Neighborhood Hits	68
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

OBSCN_HUMAN
NC score	0.074172 (rank : 494)	θ value	θ > 10 (rank : 682)
Query Neighborhood Hits	185	Target Neighborhood Hits	1931	Shared Neighborhood Hits	62
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

STK10_HUMAN
NC score	0.074033 (rank : 495)	θ value	θ > 10 (rank : 852)
Query Neighborhood Hits	185	Target Neighborhood Hits	1921	Shared Neighborhood Hits	63
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

PSCBP_HUMAN
NC score	0.073913 (rank : 496)	θ value	θ > 10 (rank : 754)
Query Neighborhood Hits	185	Target Neighborhood Hits	123	Shared Neighborhood Hits	33
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

SLK_HUMAN
NC score	0.073852 (rank : 497)	θ value	θ > 10 (rank : 818)
Query Neighborhood Hits	185	Target Neighborhood Hits	1775	Shared Neighborhood Hits	64
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

HIPK1_HUMAN
NC score	0.073739 (rank : 498)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	185	Target Neighborhood Hits	843	Shared Neighborhood Hits	47
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

E2AK2_HUMAN
NC score	0.073719 (rank : 499)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	185	Target Neighborhood Hits	856	Shared Neighborhood Hits	40
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

PXK_HUMAN
NC score	0.073717 (rank : 500)	θ value	θ > 10 (rank : 760)
Query Neighborhood Hits	185	Target Neighborhood Hits	216	Shared Neighborhood Hits	20
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

CDC7_MOUSE
NC score	0.073716 (rank : 501)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	185	Target Neighborhood Hits	641	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Z0H0, Q9Z2Y7	Gene names	Cdc7, Cdc7l1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (muCdc7).

LAP4_MOUSE
NC score	0.073614 (rank : 502)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	185	Target Neighborhood Hits	590	Shared Neighborhood Hits	50
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

RHPN1_HUMAN
NC score	0.073579 (rank : 503)	θ value	θ > 10 (rank : 784)
Query Neighborhood Hits	185	Target Neighborhood Hits	158	Shared Neighborhood Hits	40
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

HIPK1_MOUSE
NC score	0.073529 (rank : 504)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	185	Target Neighborhood Hits	838	Shared Neighborhood Hits	44
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

TLK2_HUMAN
NC score	0.073505 (rank : 505)	θ value	θ > 10 (rank : 902)
Query Neighborhood Hits	185	Target Neighborhood Hits	1044	Shared Neighborhood Hits	48
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

E2AK4_MOUSE
NC score	0.073474 (rank : 506)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	185	Target Neighborhood Hits	984	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

M3K2_MOUSE
NC score	0.073461 (rank : 507)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	185	Target Neighborhood Hits	846	Shared Neighborhood Hits	41
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M4K5_MOUSE
NC score	0.073440 (rank : 508)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	185	Target Neighborhood Hits	839	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

TLK2_MOUSE
NC score	0.073368 (rank : 509)	θ value	θ > 10 (rank : 903)
Query Neighborhood Hits	185	Target Neighborhood Hits	1088	Shared Neighborhood Hits	48
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

TLK1_HUMAN
NC score	0.073283 (rank : 510)	θ value	θ > 10 (rank : 900)
Query Neighborhood Hits	185	Target Neighborhood Hits	967	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

M4K4_HUMAN
NC score	0.073189 (rank : 511)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	185	Target Neighborhood Hits	1589	Shared Neighborhood Hits	64
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

M4K5_HUMAN
NC score	0.073179 (rank : 512)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	185	Target Neighborhood Hits	845	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

MYO3A_MOUSE
NC score	0.073091 (rank : 513)	θ value	θ > 10 (rank : 649)
Query Neighborhood Hits	185	Target Neighborhood Hits	902	Shared Neighborhood Hits	44
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

TLK1_MOUSE
NC score	0.073069 (rank : 514)	θ value	θ > 10 (rank : 901)
Query Neighborhood Hits	185	Target Neighborhood Hits	947	Shared Neighborhood Hits	44
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

M4K4_MOUSE
NC score	0.073063 (rank : 515)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	185	Target Neighborhood Hits	1560	Shared Neighborhood Hits	64
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

SNTG2_HUMAN
NC score	0.073063 (rank : 516)	θ value	θ > 10 (rank : 834)
Query Neighborhood Hits	185	Target Neighborhood Hits	191	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

TTK_HUMAN
NC score	0.073050 (rank : 517)	θ value	θ > 10 (rank : 925)
Query Neighborhood Hits	185	Target Neighborhood Hits	816	Shared Neighborhood Hits	40
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

SHAN2_MOUSE
NC score	0.073047 (rank : 518)	θ value	θ > 10 (rank : 817)
Query Neighborhood Hits	185	Target Neighborhood Hits	446	Shared Neighborhood Hits	55
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

WNK3_HUMAN
NC score	0.073039 (rank : 519)	θ value	θ > 10 (rank : 958)
Query Neighborhood Hits	185	Target Neighborhood Hits	948	Shared Neighborhood Hits	42
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

M3K4_HUMAN
NC score	0.072794 (rank : 520)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	185	Target Neighborhood Hits	911	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

WEE1B_MOUSE
NC score	0.072678 (rank : 521)	θ value	θ > 10 (rank : 952)
Query Neighborhood Hits	185	Target Neighborhood Hits	765	Shared Neighborhood Hits	44
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

MINK1_HUMAN
NC score	0.072645 (rank : 522)	θ value	θ > 10 (rank : 577)
Query Neighborhood Hits	185	Target Neighborhood Hits	1477	Shared Neighborhood Hits	69
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

RIPK3_HUMAN
NC score	0.072579 (rank : 523)	θ value	θ > 10 (rank : 793)
Query Neighborhood Hits	185	Target Neighborhood Hits	828	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

STK25_HUMAN
NC score	0.072576 (rank : 524)	θ value	θ > 10 (rank : 859)
Query Neighborhood Hits	185	Target Neighborhood Hits	853	Shared Neighborhood Hits	40
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

GSK3A_HUMAN
NC score	0.072540 (rank : 525)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	185	Target Neighborhood Hits	835	Shared Neighborhood Hits	40
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

HIPK3_MOUSE
NC score	0.072536 (rank : 526)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	185	Target Neighborhood Hits	857	Shared Neighborhood Hits	42
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

M3K4_MOUSE
NC score	0.072535 (rank : 527)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	185	Target Neighborhood Hits	924	Shared Neighborhood Hits	45
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

STK25_MOUSE
NC score	0.072517 (rank : 528)	θ value	θ > 10 (rank : 860)
Query Neighborhood Hits	185	Target Neighborhood Hits	851	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK3_HUMAN
NC score	0.072472 (rank : 529)	θ value	θ > 10 (rank : 869)
Query Neighborhood Hits	185	Target Neighborhood Hits	861	Shared Neighborhood Hits	42
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

IL16_HUMAN
NC score	0.072408 (rank : 530)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	185	Target Neighborhood Hits	207	Shared Neighborhood Hits	35
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

E2AK4_HUMAN
NC score	0.072234 (rank : 531)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	185	Target Neighborhood Hits	1012	Shared Neighborhood Hits	49
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

MINK1_MOUSE
NC score	0.072224 (rank : 532)	θ value	θ > 10 (rank : 578)
Query Neighborhood Hits	185	Target Neighborhood Hits	1451	Shared Neighborhood Hits	65
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

HIPK3_HUMAN
NC score	0.072195 (rank : 533)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	185	Target Neighborhood Hits	867	Shared Neighborhood Hits	43
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

DYRK3_HUMAN
NC score	0.072085 (rank : 534)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	185	Target Neighborhood Hits	798	Shared Neighborhood Hits	40
SwissProt Accessions	O43781	Gene names	DYRK3
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1).

MYO3A_HUMAN
NC score	0.072040 (rank : 535)	θ value	θ > 10 (rank : 648)
Query Neighborhood Hits	185	Target Neighborhood Hits	1033	Shared Neighborhood Hits	45
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

STK39_MOUSE
NC score	0.071961 (rank : 536)	θ value	θ > 10 (rank : 868)
Query Neighborhood Hits	185	Target Neighborhood Hits	915	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

PFTK1_MOUSE
NC score	0.071949 (rank : 537)	θ value	θ > 10 (rank : 720)
Query Neighborhood Hits	185	Target Neighborhood Hits	835	Shared Neighborhood Hits	42
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

NEK6_HUMAN
NC score	0.071904 (rank : 538)	θ value	θ > 10 (rank : 664)
Query Neighborhood Hits	185	Target Neighborhood Hits	848	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

OXSR1_MOUSE
NC score	0.071898 (rank : 539)	θ value	θ > 10 (rank : 686)
Query Neighborhood Hits	185	Target Neighborhood Hits	865	Shared Neighborhood Hits	41
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

PRP4B_MOUSE
NC score	0.071897 (rank : 540)	θ value	θ > 10 (rank : 753)
Query Neighborhood Hits	185	Target Neighborhood Hits	1040	Shared Neighborhood Hits	49
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

NEK6_MOUSE
NC score	0.071883 (rank : 541)	θ value	θ > 10 (rank : 665)
Query Neighborhood Hits	185	Target Neighborhood Hits	851	Shared Neighborhood Hits	40
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

MST4_MOUSE
NC score	0.071882 (rank : 542)	θ value	θ > 10 (rank : 644)
Query Neighborhood Hits	185	Target Neighborhood Hits	860	Shared Neighborhood Hits	40
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

STK39_HUMAN
NC score	0.071875 (rank : 543)	θ value	θ > 10 (rank : 867)
Query Neighborhood Hits	185	Target Neighborhood Hits	882	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

MST4_HUMAN
NC score	0.071850 (rank : 544)	θ value	θ > 10 (rank : 643)
Query Neighborhood Hits	185	Target Neighborhood Hits	852	Shared Neighborhood Hits	40
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

STK3_MOUSE
NC score	0.071821 (rank : 545)	θ value	θ > 10 (rank : 870)
Query Neighborhood Hits	185	Target Neighborhood Hits	869	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

STK24_MOUSE
NC score	0.071751 (rank : 546)	θ value	θ > 10 (rank : 858)
Query Neighborhood Hits	185	Target Neighborhood Hits	856	Shared Neighborhood Hits	40
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

MP2K3_HUMAN
NC score	0.071741 (rank : 547)	θ value	θ > 10 (rank : 619)
Query Neighborhood Hits	185	Target Neighborhood Hits	825	Shared Neighborhood Hits	40
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

TNIK_HUMAN
NC score	0.071740 (rank : 548)	θ value	θ > 10 (rank : 906)
Query Neighborhood Hits	185	Target Neighborhood Hits	1570	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

STK24_HUMAN
NC score	0.071718 (rank : 549)	θ value	θ > 10 (rank : 857)
Query Neighborhood Hits	185	Target Neighborhood Hits	853	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

PRP4B_HUMAN
NC score	0.071538 (rank : 550)	θ value	θ > 10 (rank : 752)
Query Neighborhood Hits	185	Target Neighborhood Hits	1030	Shared Neighborhood Hits	51
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

HIPK4_HUMAN
NC score	0.071502 (rank : 551)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	185	Target Neighborhood Hits	799	Shared Neighborhood Hits	40
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

NEK7_MOUSE
NC score	0.071478 (rank : 552)	θ value	θ > 10 (rank : 667)
Query Neighborhood Hits	185	Target Neighborhood Hits	847	Shared Neighborhood Hits	40
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK7_HUMAN
NC score	0.071369 (rank : 553)	θ value	θ > 10 (rank : 666)
Query Neighborhood Hits	185	Target Neighborhood Hits	846	Shared Neighborhood Hits	40
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

OXSR1_HUMAN
NC score	0.071364 (rank : 554)	θ value	θ > 10 (rank : 685)
Query Neighborhood Hits	185	Target Neighborhood Hits	874	Shared Neighborhood Hits	40
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

PFTK1_HUMAN
NC score	0.071331 (rank : 555)	θ value	θ > 10 (rank : 719)
Query Neighborhood Hits	185	Target Neighborhood Hits	834	Shared Neighborhood Hits	41
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

CDK3_MOUSE
NC score	0.071295 (rank : 556)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	185	Target Neighborhood Hits	829	Shared Neighborhood Hits	40
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

ERN2_MOUSE
NC score	0.071187 (rank : 557)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	185	Target Neighborhood Hits	825	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

M4K1_HUMAN
NC score	0.071158 (rank : 558)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	185	Target Neighborhood Hits	884	Shared Neighborhood Hits	40
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

M3K10_HUMAN
NC score	0.071038 (rank : 559)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	185	Target Neighborhood Hits	1071	Shared Neighborhood Hits	59
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

STK4_MOUSE
NC score	0.071002 (rank : 560)	θ value	θ > 10 (rank : 874)
Query Neighborhood Hits	185	Target Neighborhood Hits	873	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

PXK_MOUSE
NC score	0.070874 (rank : 561)	θ value	θ > 10 (rank : 761)
Query Neighborhood Hits	185	Target Neighborhood Hits	320	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

STK4_HUMAN
NC score	0.070864 (rank : 562)	θ value	θ > 10 (rank : 873)
Query Neighborhood Hits	185	Target Neighborhood Hits	870	Shared Neighborhood Hits	41
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

M4K1_MOUSE
NC score	0.070845 (rank : 563)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	185	Target Neighborhood Hits	858	Shared Neighborhood Hits	40
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

NRK_MOUSE
NC score	0.070681 (rank : 564)	θ value	θ > 10 (rank : 677)
Query Neighborhood Hits	185	Target Neighborhood Hits	899	Shared Neighborhood Hits	45
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

IKKE_MOUSE
NC score	0.070667 (rank : 565)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	185	Target Neighborhood Hits	848	Shared Neighborhood Hits	41
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

LRRK1_HUMAN
NC score	0.070662 (rank : 566)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	185	Target Neighborhood Hits	1237	Shared Neighborhood Hits	39
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

MPP3_HUMAN
NC score	0.070628 (rank : 567)	θ value	θ > 10 (rank : 632)
Query Neighborhood Hits	185	Target Neighborhood Hits	171	Shared Neighborhood Hits	34
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

TITIN_HUMAN
NC score	0.070627 (rank : 568)	θ value	θ > 10 (rank : 899)
Query Neighborhood Hits	185	Target Neighborhood Hits	2923	Shared Neighborhood Hits	86
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

GSK3B_HUMAN
NC score	0.070614 (rank : 569)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	185	Target Neighborhood Hits	801	Shared Neighborhood Hits	40
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_MOUSE
NC score	0.070614 (rank : 570)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	185	Target Neighborhood Hits	800	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

MPP3_MOUSE
NC score	0.070609 (rank : 571)	θ value	θ > 10 (rank : 633)
Query Neighborhood Hits	185	Target Neighborhood Hits	165	Shared Neighborhood Hits	33
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

CD2L1_MOUSE
NC score	0.070452 (rank : 572)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	185	Target Neighborhood Hits	1463	Shared Neighborhood Hits	59
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

CD2L2_HUMAN
NC score	0.070322 (rank : 573)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	185	Target Neighborhood Hits	1439	Shared Neighborhood Hits	64
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

DAPK1_HUMAN
NC score	0.070294 (rank : 574)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	185	Target Neighborhood Hits	1130	Shared Neighborhood Hits	41
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

CDK2_HUMAN
NC score	0.070289 (rank : 575)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	185	Target Neighborhood Hits	832	Shared Neighborhood Hits	40
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

DAPK1_MOUSE
NC score	0.070275 (rank : 576)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	185	Target Neighborhood Hits	1138	Shared Neighborhood Hits	41
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

M3K8_MOUSE
NC score	0.070169 (rank : 577)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	185	Target Neighborhood Hits	815	Shared Neighborhood Hits	40
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

CD2L1_HUMAN
NC score	0.070155 (rank : 578)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	185	Target Neighborhood Hits	1467	Shared Neighborhood Hits	61
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

IRAK1_MOUSE
NC score	0.070153 (rank : 579)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	185	Target Neighborhood Hits	784	Shared Neighborhood Hits	41
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

SNTB2_HUMAN
NC score	0.070099 (rank : 580)	θ value	θ > 10 (rank : 830)
Query Neighborhood Hits	185	Target Neighborhood Hits	180	Shared Neighborhood Hits	37
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

YSK4_HUMAN
NC score	0.069963 (rank : 581)	θ value	θ > 10 (rank : 961)
Query Neighborhood Hits	185	Target Neighborhood Hits	921	Shared Neighborhood Hits	42
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

M3K9_HUMAN
NC score	0.069866 (rank : 582)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	185	Target Neighborhood Hits	1123	Shared Neighborhood Hits	53
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

RASF3_MOUSE
NC score	0.069723 (rank : 583)	θ value	θ > 10 (rank : 766)
Query Neighborhood Hits	185	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q99P51, Q3TJ17	Gene names	Rassf3
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 3.

CDKL2_MOUSE
NC score	0.069697 (rank : 584)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	185	Target Neighborhood Hits	854	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

RASF3_HUMAN
NC score	0.069670 (rank : 585)	θ value	θ > 10 (rank : 765)
Query Neighborhood Hits	185	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	Q86WH2, Q86WH1	Gene names	RASSF3
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 3.

SNTB2_MOUSE
NC score	0.069670 (rank : 586)	θ value	θ > 10 (rank : 831)
Query Neighborhood Hits	185	Target Neighborhood Hits	181	Shared Neighborhood Hits	37
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

RIPK2_MOUSE
NC score	0.069651 (rank : 587)	θ value	θ > 10 (rank : 792)
Query Neighborhood Hits	185	Target Neighborhood Hits	776	Shared Neighborhood Hits	40
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

NRK_HUMAN
NC score	0.069624 (rank : 588)	θ value	θ > 10 (rank : 676)
Query Neighborhood Hits	185	Target Neighborhood Hits	931	Shared Neighborhood Hits	44
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

MP2K4_MOUSE
NC score	0.069588 (rank : 589)	θ value	θ > 10 (rank : 622)
Query Neighborhood Hits	185	Target Neighborhood Hits	833	Shared Neighborhood Hits	40
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

M3K8_HUMAN
NC score	0.069570 (rank : 590)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	185	Target Neighborhood Hits	807	Shared Neighborhood Hits	40
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

LIMK1_HUMAN
NC score	0.069568 (rank : 591)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	185	Target Neighborhood Hits	1005	Shared Neighborhood Hits	54
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

MP2K4_HUMAN
NC score	0.069528 (rank : 592)	θ value	θ > 10 (rank : 621)
Query Neighborhood Hits	185	Target Neighborhood Hits	832	Shared Neighborhood Hits	40
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MK15_MOUSE
NC score	0.069425 (rank : 593)	θ value	θ > 10 (rank : 604)
Query Neighborhood Hits	185	Target Neighborhood Hits	843	Shared Neighborhood Hits	44
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

MP2K6_HUMAN
NC score	0.069302 (rank : 594)	θ value	θ > 10 (rank : 625)
Query Neighborhood Hits	185	Target Neighborhood Hits	830	Shared Neighborhood Hits	40
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

CDKL2_HUMAN
NC score	0.069156 (rank : 595)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	185	Target Neighborhood Hits	838	Shared Neighborhood Hits	40
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

SYTL2_MOUSE
NC score	0.069042 (rank : 596)	θ value	0.279714 (rank : 70)
Query Neighborhood Hits	185	Target Neighborhood Hits	253	Shared Neighborhood Hits	18
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

LIMK2_MOUSE
NC score	0.068987 (rank : 597)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	185	Target Neighborhood Hits	998	Shared Neighborhood Hits	61
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

CDKL3_MOUSE
NC score	0.068911 (rank : 598)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	185	Target Neighborhood Hits	857	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

AL2S7_HUMAN
NC score	0.068872 (rank : 599)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	185	Target Neighborhood Hits	831	Shared Neighborhood Hits	40
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

CSK22_HUMAN
NC score	0.068859 (rank : 600)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	185	Target Neighborhood Hits	758	Shared Neighborhood Hits	39
SwissProt Accessions	P19784	Gene names	CSNK2A2, CK2A2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

CSK21_MOUSE
NC score	0.068763 (rank : 601)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	185	Target Neighborhood Hits	770	Shared Neighborhood Hits	39
SwissProt Accessions	Q60737	Gene names	Csnk2a1, Ckiia
Domain Architecture
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

LIMK1_MOUSE
NC score	0.068726 (rank : 602)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	185	Target Neighborhood Hits	1008	Shared Neighborhood Hits	52
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

MPP4_MOUSE
NC score	0.068720 (rank : 603)	θ value	θ > 10 (rank : 635)
Query Neighborhood Hits	185	Target Neighborhood Hits	188	Shared Neighborhood Hits	32
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

K1849_MOUSE
NC score	0.068690 (rank : 604)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	185	Target Neighborhood Hits	335	Shared Neighborhood Hits	42
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

CSK22_MOUSE
NC score	0.068628 (rank : 605)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	185	Target Neighborhood Hits	758	Shared Neighborhood Hits	39
SwissProt Accessions	O54833	Gene names	Csnk2a2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

CDKL3_HUMAN
NC score	0.068613 (rank : 606)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	185	Target Neighborhood Hits	853	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

MP2K6_MOUSE
NC score	0.068563 (rank : 607)	θ value	θ > 10 (rank : 626)
Query Neighborhood Hits	185	Target Neighborhood Hits	830	Shared Neighborhood Hits	40
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

DGKE_HUMAN
NC score	0.068499 (rank : 608)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	185	Target Neighborhood Hits	32	Shared Neighborhood Hits	13
SwissProt Accessions	P52429, Q9UKQ3	Gene names	DGKE, DAGK5
Domain Architecture
Description	Diacylglycerol kinase epsilon (EC 2.7.1.107) (Diglyceride kinase epsilon) (DGK-epsilon) (DAG kinase epsilon).

APBA1_HUMAN
NC score	0.068435 (rank : 609)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	185	Target Neighborhood Hits	325	Shared Neighborhood Hits	46
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

PCTK3_MOUSE
NC score	0.068298 (rank : 610)	θ value	θ > 10 (rank : 708)
Query Neighborhood Hits	185	Target Neighborhood Hits	834	Shared Neighborhood Hits	41
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

LIMK2_HUMAN
NC score	0.068195 (rank : 611)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	185	Target Neighborhood Hits	986	Shared Neighborhood Hits	60
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

CDC2_HUMAN
NC score	0.068185 (rank : 612)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	185	Target Neighborhood Hits	842	Shared Neighborhood Hits	40
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDC2_MOUSE
NC score	0.068162 (rank : 613)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	185	Target Neighborhood Hits	838	Shared Neighborhood Hits	40
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

3BP1_HUMAN
NC score	0.068154 (rank : 614)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	185	Target Neighborhood Hits	376	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

PICK1_HUMAN
NC score	0.068119 (rank : 615)	θ value	5.27518 (rank : 150)
Query Neighborhood Hits	185	Target Neighborhood Hits	132	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PCTK3_HUMAN
NC score	0.068032 (rank : 616)	θ value	θ > 10 (rank : 707)
Query Neighborhood Hits	185	Target Neighborhood Hits	827	Shared Neighborhood Hits	40
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

PICK1_MOUSE
NC score	0.067990 (rank : 617)	θ value	5.27518 (rank : 151)
Query Neighborhood Hits	185	Target Neighborhood Hits	131	Shared Neighborhood Hits	32
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

CDK2_MOUSE
NC score	0.067983 (rank : 618)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	185	Target Neighborhood Hits	828	Shared Neighborhood Hits	40
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

CDKL4_MOUSE
NC score	0.067865 (rank : 619)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	185	Target Neighborhood Hits	833	Shared Neighborhood Hits	40
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

PCTK2_MOUSE
NC score	0.067831 (rank : 620)	θ value	θ > 10 (rank : 706)
Query Neighborhood Hits	185	Target Neighborhood Hits	836	Shared Neighborhood Hits	40
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

CSK21_HUMAN
NC score	0.067781 (rank : 621)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	185	Target Neighborhood Hits	772	Shared Neighborhood Hits	39
SwissProt Accessions	P68400, P19138, P20426, Q14013	Gene names	CSNK2A1, CK2A1
Domain Architecture	No domain graphic available
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

PCTK2_HUMAN
NC score	0.067762 (rank : 622)	θ value	θ > 10 (rank : 705)
Query Neighborhood Hits	185	Target Neighborhood Hits	837	Shared Neighborhood Hits	40
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK1_MOUSE
NC score	0.067740 (rank : 623)	θ value	θ > 10 (rank : 704)
Query Neighborhood Hits	185	Target Neighborhood Hits	832	Shared Neighborhood Hits	40
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

APBA2_MOUSE
NC score	0.067685 (rank : 624)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	185	Target Neighborhood Hits	219	Shared Neighborhood Hits	42
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

LRRK1_MOUSE
NC score	0.067645 (rank : 625)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	185	Target Neighborhood Hits	1267	Shared Neighborhood Hits	38
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

UHMK1_MOUSE
NC score	0.067639 (rank : 626)	θ value	θ > 10 (rank : 936)
Query Neighborhood Hits	185	Target Neighborhood Hits	809	Shared Neighborhood Hits	40
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

PCTK1_HUMAN
NC score	0.067615 (rank : 627)	θ value	θ > 10 (rank : 703)
Query Neighborhood Hits	185	Target Neighborhood Hits	832	Shared Neighborhood Hits	40
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

APBA2_HUMAN
NC score	0.067577 (rank : 628)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	185	Target Neighborhood Hits	220	Shared Neighborhood Hits	41
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

UHMK1_HUMAN
NC score	0.067554 (rank : 629)	θ value	θ > 10 (rank : 935)
Query Neighborhood Hits	185	Target Neighborhood Hits	808	Shared Neighborhood Hits	40
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

M3KL4_HUMAN
NC score	0.067491 (rank : 630)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	185	Target Neighborhood Hits	1087	Shared Neighborhood Hits	56
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

CDKL4_HUMAN
NC score	0.067268 (rank : 631)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	185	Target Neighborhood Hits	828	Shared Neighborhood Hits	40
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

WEE1B_HUMAN
NC score	0.067122 (rank : 632)	θ value	θ > 10 (rank : 951)
Query Neighborhood Hits	185	Target Neighborhood Hits	836	Shared Neighborhood Hits	43
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

MOS_HUMAN
NC score	0.067037 (rank : 633)	θ value	θ > 10 (rank : 613)
Query Neighborhood Hits	185	Target Neighborhood Hits	829	Shared Neighborhood Hits	40
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

M3K13_HUMAN
NC score	0.067035 (rank : 634)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	185	Target Neighborhood Hits	911	Shared Neighborhood Hits	40
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

SNTG1_HUMAN
NC score	0.067026 (rank : 635)	θ value	θ > 10 (rank : 832)
Query Neighborhood Hits	185	Target Neighborhood Hits	181	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

TMEPA_MOUSE
NC score	0.067011 (rank : 636)	θ value	1.38821 (rank : 99)
Query Neighborhood Hits	185	Target Neighborhood Hits	46	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D7R2, Q9EQH9	Gene names	Tmepai, N4wbp4
Domain Architecture	No domain graphic available
Description	Transmembrane prostate androgen-induced protein (NEDD4 WW domain- binding protein 4).

IL16_MOUSE
NC score	0.066993 (rank : 637)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	185	Target Neighborhood Hits	189	Shared Neighborhood Hits	32
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

E2AK1_MOUSE
NC score	0.066978 (rank : 638)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	185	Target Neighborhood Hits	821	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

CDKL1_MOUSE
NC score	0.066649 (rank : 639)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	185	Target Neighborhood Hits	829	Shared Neighborhood Hits	40
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

RPGF6_HUMAN
NC score	0.066641 (rank : 640)	θ value	θ > 10 (rank : 803)
Query Neighborhood Hits	185	Target Neighborhood Hits	266	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

RIPK2_HUMAN
NC score	0.066613 (rank : 641)	θ value	θ > 10 (rank : 791)
Query Neighborhood Hits	185	Target Neighborhood Hits	774	Shared Neighborhood Hits	40
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

SNTG1_MOUSE
NC score	0.066556 (rank : 642)	θ value	θ > 10 (rank : 833)
Query Neighborhood Hits	185	Target Neighborhood Hits	179	Shared Neighborhood Hits	40
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

CDK6_MOUSE
NC score	0.066378 (rank : 643)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	185	Target Neighborhood Hits	837	Shared Neighborhood Hits	40
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

CCRK_MOUSE
NC score	0.066328 (rank : 644)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	185	Target Neighborhood Hits	832	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

TCGAP_MOUSE
NC score	0.066279 (rank : 645)	θ value	θ > 10 (rank : 890)
Query Neighborhood Hits	185	Target Neighborhood Hits	409	Shared Neighborhood Hits	23
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

CDKL1_HUMAN
NC score	0.066238 (rank : 646)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	185	Target Neighborhood Hits	830	Shared Neighborhood Hits	40
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

MK15_HUMAN
NC score	0.066124 (rank : 647)	θ value	θ > 10 (rank : 603)
Query Neighborhood Hits	185	Target Neighborhood Hits	1038	Shared Neighborhood Hits	46
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

CDK3_HUMAN
NC score	0.066116 (rank : 648)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	185	Target Neighborhood Hits	843	Shared Neighborhood Hits	40
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

MAK_MOUSE
NC score	0.066066 (rank : 649)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	185	Target Neighborhood Hits	873	Shared Neighborhood Hits	42
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

ERN1_MOUSE
NC score	0.066008 (rank : 650)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	185	Target Neighborhood Hits	823	Shared Neighborhood Hits	40
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

SNTG2_MOUSE
NC score	0.065985 (rank : 651)	θ value	θ > 10 (rank : 835)
Query Neighborhood Hits	185	Target Neighborhood Hits	176	Shared Neighborhood Hits	41
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

CD2L7_HUMAN
NC score	0.065919 (rank : 652)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	185	Target Neighborhood Hits	1275	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

CCRK_HUMAN
NC score	0.065738 (rank : 653)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	185	Target Neighborhood Hits	835	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

CDK7_MOUSE
NC score	0.065717 (rank : 654)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	185	Target Neighborhood Hits	835	Shared Neighborhood Hits	40
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

CDK6_HUMAN
NC score	0.065653 (rank : 655)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	185	Target Neighborhood Hits	837	Shared Neighborhood Hits	40
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

MAK_HUMAN
NC score	0.065648 (rank : 656)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	185	Target Neighborhood Hits	857	Shared Neighborhood Hits	40
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

ERN2_HUMAN
NC score	0.065634 (rank : 657)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	185	Target Neighborhood Hits	844	Shared Neighborhood Hits	41
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

CDK7_HUMAN
NC score	0.065576 (rank : 658)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	185	Target Neighborhood Hits	833	Shared Neighborhood Hits	40
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

ERN1_HUMAN
NC score	0.065556 (rank : 659)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	185	Target Neighborhood Hits	829	Shared Neighborhood Hits	40
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

IRAK1_HUMAN
NC score	0.065528 (rank : 660)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	185	Target Neighborhood Hits	820	Shared Neighborhood Hits	46
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

TESK2_HUMAN
NC score	0.065523 (rank : 661)	θ value	θ > 10 (rank : 895)
Query Neighborhood Hits	185	Target Neighborhood Hits	851	Shared Neighborhood Hits	41
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

KSR1_MOUSE
NC score	0.065342 (rank : 662)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	185	Target Neighborhood Hits	870	Shared Neighborhood Hits	53
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

STK16_HUMAN
NC score	0.065339 (rank : 663)	θ value	θ > 10 (rank : 855)
Query Neighborhood Hits	185	Target Neighborhood Hits	824	Shared Neighborhood Hits	40
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

BAIP3_HUMAN
NC score	0.065320 (rank : 664)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	185	Target Neighborhood Hits	108	Shared Neighborhood Hits	11
SwissProt Accessions	O94812, O94839, Q2M226, Q658J2, Q76N05, Q96RZ3, Q9UJK1	Gene names	BAIAP3, KIAA0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

DYRK4_HUMAN
NC score	0.065307 (rank : 665)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	185	Target Neighborhood Hits	750	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NR20, Q8NEF2, Q92631	Gene names	DYRK4
Domain Architecture	No domain graphic available
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1).

CDK5_HUMAN
NC score	0.065294 (rank : 666)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	185	Target Neighborhood Hits	826	Shared Neighborhood Hits	40
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

CDK5_MOUSE
NC score	0.065280 (rank : 667)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	185	Target Neighborhood Hits	826	Shared Neighborhood Hits	40
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

PCLO_HUMAN
NC score	0.065207 (rank : 668)	θ value	θ > 10 (rank : 701)
Query Neighborhood Hits	185	Target Neighborhood Hits	2046	Shared Neighborhood Hits	79
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

ICK_MOUSE
NC score	0.065190 (rank : 669)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	185	Target Neighborhood Hits	860	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

M3K12_HUMAN
NC score	0.065168 (rank : 670)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	185	Target Neighborhood Hits	940	Shared Neighborhood Hits	46
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

KSR2_HUMAN
NC score	0.065161 (rank : 671)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	185	Target Neighborhood Hits	920	Shared Neighborhood Hits	70
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

TESK1_MOUSE
NC score	0.065098 (rank : 672)	θ value	θ > 10 (rank : 894)
Query Neighborhood Hits	185	Target Neighborhood Hits	862	Shared Neighborhood Hits	45
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TAOK2_HUMAN
NC score	0.064973 (rank : 673)	θ value	θ > 10 (rank : 883)
Query Neighborhood Hits	185	Target Neighborhood Hits	1172	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

TAOK3_MOUSE
NC score	0.064863 (rank : 674)	θ value	θ > 10 (rank : 886)
Query Neighborhood Hits	185	Target Neighborhood Hits	1458	Shared Neighborhood Hits	57
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

APBA3_HUMAN
NC score	0.064775 (rank : 675)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	185	Target Neighborhood Hits	201	Shared Neighborhood Hits	46
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

IRAK4_MOUSE
NC score	0.064771 (rank : 676)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	185	Target Neighborhood Hits	820	Shared Neighborhood Hits	41
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

TAOK1_MOUSE
NC score	0.064731 (rank : 677)	θ value	θ > 10 (rank : 882)
Query Neighborhood Hits	185	Target Neighborhood Hits	1720	Shared Neighborhood Hits	62
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

ICK_HUMAN
NC score	0.064730 (rank : 678)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	185	Target Neighborhood Hits	867	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

TAOK1_HUMAN
NC score	0.064609 (rank : 679)	θ value	θ > 10 (rank : 881)
Query Neighborhood Hits	185	Target Neighborhood Hits	1734	Shared Neighborhood Hits	63
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

M3K12_MOUSE
NC score	0.064499 (rank : 680)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	185	Target Neighborhood Hits	957	Shared Neighborhood Hits	46
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

RIPK1_HUMAN
NC score	0.064486 (rank : 681)	θ value	θ > 10 (rank : 789)
Query Neighborhood Hits	185	Target Neighborhood Hits	891	Shared Neighborhood Hits	41
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

TESK1_HUMAN
NC score	0.064397 (rank : 682)	θ value	θ > 10 (rank : 893)
Query Neighborhood Hits	185	Target Neighborhood Hits	864	Shared Neighborhood Hits	45
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TAOK2_MOUSE
NC score	0.064388 (rank : 683)	θ value	θ > 10 (rank : 884)
Query Neighborhood Hits	185	Target Neighborhood Hits	1373	Shared Neighborhood Hits	56
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

RGS12_HUMAN
NC score	0.064261 (rank : 684)	θ value	θ > 10 (rank : 772)
Query Neighborhood Hits	185	Target Neighborhood Hits	333	Shared Neighborhood Hits	46
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

TESK2_MOUSE
NC score	0.064115 (rank : 685)	θ value	θ > 10 (rank : 896)
Query Neighborhood Hits	185	Target Neighborhood Hits	833	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

MLTK_MOUSE
NC score	0.063956 (rank : 686)	θ value	θ > 10 (rank : 610)
Query Neighborhood Hits	185	Target Neighborhood Hits	874	Shared Neighborhood Hits	42
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

RIPK1_MOUSE
NC score	0.063837 (rank : 687)	θ value	θ > 10 (rank : 790)
Query Neighborhood Hits	185	Target Neighborhood Hits	874	Shared Neighborhood Hits	40
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

E2AK1_HUMAN
NC score	0.063625 (rank : 688)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	185	Target Neighborhood Hits	833	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

MK09_HUMAN
NC score	0.063524 (rank : 689)	θ value	θ > 10 (rank : 591)
Query Neighborhood Hits	185	Target Neighborhood Hits	842	Shared Neighborhood Hits	41
SwissProt Accessions	P45984, Q15708, Q15710, Q15711, Q8N5C5	Gene names	MAPK9, JNK2, PRKM9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).

MLTK_HUMAN
NC score	0.063434 (rank : 690)	θ value	θ > 10 (rank : 609)
Query Neighborhood Hits	185	Target Neighborhood Hits	911	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

SNTA1_MOUSE
NC score	0.063380 (rank : 691)	θ value	θ > 10 (rank : 827)
Query Neighborhood Hits	185	Target Neighborhood Hits	170	Shared Neighborhood Hits	38
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

TAOK3_HUMAN
NC score	0.063379 (rank : 692)	θ value	θ > 10 (rank : 885)
Query Neighborhood Hits	185	Target Neighborhood Hits	1494	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

CDK10_HUMAN
NC score	0.063235 (rank : 693)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	185	Target Neighborhood Hits	831	Shared Neighborhood Hits	40
SwissProt Accessions	Q15131, Q15130	Gene names	CDK10
Domain Architecture
Description	Cell division protein kinase 10 (EC 2.7.11.22) (Serine/threonine- protein kinase PISSLRE).

RIMS2_HUMAN
NC score	0.063217 (rank : 694)	θ value	θ > 10 (rank : 787)
Query Neighborhood Hits	185	Target Neighborhood Hits	342	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

MK08_MOUSE
NC score	0.063173 (rank : 695)	θ value	θ > 10 (rank : 590)
Query Neighborhood Hits	185	Target Neighborhood Hits	834	Shared Neighborhood Hits	40
SwissProt Accessions	Q91Y86	Gene names	Mapk8, Jnk1, Prkm8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1).

MK08_HUMAN
NC score	0.063101 (rank : 696)	θ value	θ > 10 (rank : 589)
Query Neighborhood Hits	185	Target Neighborhood Hits	834	Shared Neighborhood Hits	40
SwissProt Accessions	P45983, Q15709, Q15712, Q15713	Gene names	MAPK8, JNK1, PRKM8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46).

E2AK3_MOUSE
NC score	0.063008 (rank : 697)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	185	Target Neighborhood Hits	851	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

BMP2K_MOUSE
NC score	0.062941 (rank : 698)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	185	Target Neighborhood Hits	874	Shared Neighborhood Hits	44
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

RIMS2_MOUSE
NC score	0.062924 (rank : 699)	θ value	θ > 10 (rank : 788)
Query Neighborhood Hits	185	Target Neighborhood Hits	376	Shared Neighborhood Hits	38
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

MK07_MOUSE
NC score	0.062864 (rank : 700)	θ value	θ > 10 (rank : 588)
Query Neighborhood Hits	185	Target Neighborhood Hits	1054	Shared Neighborhood Hits	57
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

CD2L5_MOUSE
NC score	0.062674 (rank : 701)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	185	Target Neighborhood Hits	1011	Shared Neighborhood Hits	47
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

ABL1_MOUSE
NC score	0.062644 (rank : 702)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	185	Target Neighborhood Hits	1178	Shared Neighborhood Hits	62
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

SNTA1_HUMAN
NC score	0.062528 (rank : 703)	θ value	θ > 10 (rank : 826)
Query Neighborhood Hits	185	Target Neighborhood Hits	186	Shared Neighborhood Hits	39
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

MK09_MOUSE
NC score	0.062484 (rank : 704)	θ value	θ > 10 (rank : 592)
Query Neighborhood Hits	185	Target Neighborhood Hits	843	Shared Neighborhood Hits	42
SwissProt Accessions	Q9WTU6, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5	Gene names	Mapk9, Jnk2, Prkm9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2).

CDC7_HUMAN
NC score	0.062478 (rank : 705)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	185	Target Neighborhood Hits	652	Shared Neighborhood Hits	36
SwissProt Accessions	O00311, O00558	Gene names	CDC7, CDC7L1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (HsCdc7) (huCdc7).

DGKE_MOUSE
NC score	0.062447 (rank : 706)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	185	Target Neighborhood Hits	30	Shared Neighborhood Hits	13
SwissProt Accessions	Q9R1C6	Gene names	Dgke
Domain Architecture
Description	Diacylglycerol kinase epsilon (EC 2.7.1.107) (Diglyceride kinase epsilon) (DGK-epsilon) (DAG kinase epsilon).

TNI3K_MOUSE
NC score	0.062383 (rank : 707)	θ value	θ > 10 (rank : 905)
Query Neighborhood Hits	185	Target Neighborhood Hits	1079	Shared Neighborhood Hits	41
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

E2AK3_HUMAN
NC score	0.062380 (rank : 708)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	185	Target Neighborhood Hits	859	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

EM55_HUMAN
NC score	0.062302 (rank : 709)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	185	Target Neighborhood Hits	228	Shared Neighborhood Hits	31
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

MK07_HUMAN
NC score	0.062266 (rank : 710)	θ value	θ > 10 (rank : 587)
Query Neighborhood Hits	185	Target Neighborhood Hits	1087	Shared Neighborhood Hits	55
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

EM55_MOUSE
NC score	0.062228 (rank : 711)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	185	Target Neighborhood Hits	221	Shared Neighborhood Hits	30
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

MOS_MOUSE
NC score	0.062207 (rank : 712)	θ value	θ > 10 (rank : 614)
Query Neighborhood Hits	185	Target Neighborhood Hits	833	Shared Neighborhood Hits	40
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

AAK1_HUMAN
NC score	0.062073 (rank : 713)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	185	Target Neighborhood Hits	1077	Shared Neighborhood Hits	59
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

CDK4_HUMAN
NC score	0.062029 (rank : 714)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	185	Target Neighborhood Hits	834	Shared Neighborhood Hits	40
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

RPGF2_HUMAN
NC score	0.062007 (rank : 715)	θ value	θ > 10 (rank : 802)
Query Neighborhood Hits	185	Target Neighborhood Hits	242	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

CD2L5_HUMAN
NC score	0.061877 (rank : 716)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	185	Target Neighborhood Hits	987	Shared Neighborhood Hits	45
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

KC1G1_HUMAN
NC score	0.061856 (rank : 717)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	185	Target Neighborhood Hits	708	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HCP0, Q96AE9, Q9HCP1	Gene names	CSNK1G1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

MK10_HUMAN
NC score	0.061725 (rank : 718)	θ value	θ > 10 (rank : 593)
Query Neighborhood Hits	185	Target Neighborhood Hits	836	Shared Neighborhood Hits	40
SwissProt Accessions	P53779, Q15707	Gene names	MAPK10, JNK3, JNK3A, PRKM10
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

CDK4_MOUSE
NC score	0.061540 (rank : 719)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	185	Target Neighborhood Hits	838	Shared Neighborhood Hits	40
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

LRRK2_HUMAN
NC score	0.061418 (rank : 720)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	185	Target Neighborhood Hits	1382	Shared Neighborhood Hits	41
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

KC1G1_MOUSE
NC score	0.061382 (rank : 721)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	185	Target Neighborhood Hits	713	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BTH8	Gene names	Csnk1g1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

3BP1_MOUSE
NC score	0.061305 (rank : 722)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	185	Target Neighborhood Hits	238	Shared Neighborhood Hits	20
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

BMP2K_HUMAN
NC score	0.061289 (rank : 723)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	185	Target Neighborhood Hits	867	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

TNI3K_HUMAN
NC score	0.061263 (rank : 724)	θ value	θ > 10 (rank : 904)
Query Neighborhood Hits	185	Target Neighborhood Hits	1084	Shared Neighborhood Hits	41
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

RHG09_HUMAN
NC score	0.061260 (rank : 725)	θ value	θ > 10 (rank : 778)
Query Neighborhood Hits	185	Target Neighborhood Hits	186	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

MK10_MOUSE
NC score	0.061218 (rank : 726)	θ value	θ > 10 (rank : 594)
Query Neighborhood Hits	185	Target Neighborhood Hits	849	Shared Neighborhood Hits	40
SwissProt Accessions	Q61831, Q9R0U6	Gene names	Mapk10, Jnk3, Prkm10, Serk2
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

IRAK4_HUMAN
NC score	0.061120 (rank : 727)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	185	Target Neighborhood Hits	816	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

WEE1_HUMAN
NC score	0.061030 (rank : 728)	θ value	θ > 10 (rank : 953)
Query Neighborhood Hits	185	Target Neighborhood Hits	777	Shared Neighborhood Hits	42
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

M3K7_MOUSE
NC score	0.061005 (rank : 729)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	185	Target Neighborhood Hits	892	Shared Neighborhood Hits	42
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

MK13_MOUSE
NC score	0.060973 (rank : 730)	θ value	θ > 10 (rank : 600)
Query Neighborhood Hits	185	Target Neighborhood Hits	832	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

RGS3_MOUSE
NC score	0.060942 (rank : 731)	θ value	0.163984 (rank : 57)
Query Neighborhood Hits	185	Target Neighborhood Hits	1621	Shared Neighborhood Hits	65
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

ABL1_HUMAN
NC score	0.060939 (rank : 732)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	185	Target Neighborhood Hits	1220	Shared Neighborhood Hits	54
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

M3K7_HUMAN
NC score	0.060919 (rank : 733)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	185	Target Neighborhood Hits	892	Shared Neighborhood Hits	41
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

WEE1_MOUSE
NC score	0.060905 (rank : 734)	θ value	θ > 10 (rank : 954)
Query Neighborhood Hits	185	Target Neighborhood Hits	794	Shared Neighborhood Hits	43
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

SNTB1_MOUSE
NC score	0.060904 (rank : 735)	θ value	θ > 10 (rank : 829)
Query Neighborhood Hits	185	Target Neighborhood Hits	160	Shared Neighborhood Hits	33
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

BTK_HUMAN
NC score	0.060891 (rank : 736)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	185	Target Neighborhood Hits	1026	Shared Neighborhood Hits	47
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

ABL2_HUMAN
NC score	0.060873 (rank : 737)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	185	Target Neighborhood Hits	1045	Shared Neighborhood Hits	52
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

KSR1_HUMAN
NC score	0.060854 (rank : 738)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	185	Target Neighborhood Hits	867	Shared Neighborhood Hits	53
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

MK11_MOUSE
NC score	0.060725 (rank : 739)	θ value	θ > 10 (rank : 596)
Query Neighborhood Hits	185	Target Neighborhood Hits	835	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

MK14_MOUSE
NC score	0.060690 (rank : 740)	θ value	θ > 10 (rank : 602)
Query Neighborhood Hits	185	Target Neighborhood Hits	838	Shared Neighborhood Hits	40
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

TMEPA_HUMAN
NC score	0.060684 (rank : 741)	θ value	3.0926 (rank : 130)
Query Neighborhood Hits	185	Target Neighborhood Hits	46	Shared Neighborhood Hits	5
SwissProt Accessions	Q969W9, Q5TDR6, Q96B72, Q9UJD3	Gene names	TMEPAI, PMEPA1, STAG1
Domain Architecture
Description	Transmembrane prostate androgen-induced protein (Solid tumor- associated 1 protein).

KC1G2_MOUSE
NC score	0.060466 (rank : 742)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	185	Target Neighborhood Hits	695	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BVP5	Gene names	Csnk1g2
Domain Architecture	No domain graphic available
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

ACK1_HUMAN
NC score	0.060457 (rank : 743)	θ value	0.47712 (rank : 74)
Query Neighborhood Hits	185	Target Neighborhood Hits	1140	Shared Neighborhood Hits	62
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

RASL1_MOUSE
NC score	0.060383 (rank : 744)	θ value	θ > 10 (rank : 768)
Query Neighborhood Hits	185	Target Neighborhood Hits	148	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

MK12_HUMAN
NC score	0.060340 (rank : 745)	θ value	θ > 10 (rank : 597)
Query Neighborhood Hits	185	Target Neighborhood Hits	830	Shared Neighborhood Hits	40
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

RBP1_MOUSE
NC score	0.060299 (rank : 746)	θ value	θ > 10 (rank : 771)
Query Neighborhood Hits	185	Target Neighborhood Hits	493	Shared Neighborhood Hits	30
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

KC1G3_HUMAN
NC score	0.060294 (rank : 747)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	185	Target Neighborhood Hits	711	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y6M4, Q86WZ7, Q9Y6M3	Gene names	CSNK1G3
Domain Architecture
Description	Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma 3).

TCGAP_HUMAN
NC score	0.060271 (rank : 748)	θ value	θ > 10 (rank : 889)
Query Neighborhood Hits	185	Target Neighborhood Hits	872	Shared Neighborhood Hits	31
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

MK13_HUMAN
NC score	0.060236 (rank : 749)	θ value	θ > 10 (rank : 599)
Query Neighborhood Hits	185	Target Neighborhood Hits	829	Shared Neighborhood Hits	41
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK14_HUMAN
NC score	0.060194 (rank : 750)	θ value	θ > 10 (rank : 601)
Query Neighborhood Hits	185	Target Neighborhood Hits	838	Shared Neighborhood Hits	40
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

BTK_MOUSE
NC score	0.060154 (rank : 751)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	185	Target Neighborhood Hits	1017	Shared Neighborhood Hits	46
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

SNTB1_HUMAN
NC score	0.060145 (rank : 752)	θ value	θ > 10 (rank : 828)
Query Neighborhood Hits	185	Target Neighborhood Hits	157	Shared Neighborhood Hits	33
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

MPP2_MOUSE
NC score	0.060051 (rank : 753)	θ value	θ > 10 (rank : 631)
Query Neighborhood Hits	185	Target Neighborhood Hits	189	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

MK11_HUMAN
NC score	0.059980 (rank : 754)	θ value	θ > 10 (rank : 595)
Query Neighborhood Hits	185	Target Neighborhood Hits	823	Shared Neighborhood Hits	40
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

JAK3_MOUSE
NC score	0.059971 (rank : 755)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	185	Target Neighborhood Hits	821	Shared Neighborhood Hits	41
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

RBP1_HUMAN
NC score	0.059904 (rank : 756)	θ value	θ > 10 (rank : 770)
Query Neighborhood Hits	185	Target Neighborhood Hits	521	Shared Neighborhood Hits	33
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

MK03_MOUSE
NC score	0.059866 (rank : 757)	θ value	θ > 10 (rank : 582)
Query Neighborhood Hits	185	Target Neighborhood Hits	840	Shared Neighborhood Hits	40
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

KC1AL_HUMAN
NC score	0.059838 (rank : 758)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	185	Target Neighborhood Hits	734	Shared Neighborhood Hits	40
SwissProt Accessions	Q8N752	Gene names	CSNK1A1L
Domain Architecture
Description	Casein kinase I isoform alpha-like (EC 2.7.11.1) (CKI-alpha-like) (CK1).

NLK_MOUSE
NC score	0.059834 (rank : 759)	θ value	θ > 10 (rank : 675)
Query Neighborhood Hits	185	Target Neighborhood Hits	839	Shared Neighborhood Hits	41
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

FER_HUMAN
NC score	0.059733 (rank : 760)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	185	Target Neighborhood Hits	1278	Shared Neighborhood Hits	57
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

ABR_HUMAN
NC score	0.059726 (rank : 761)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	185	Target Neighborhood Hits	166	Shared Neighborhood Hits	20
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

NLK_HUMAN
NC score	0.059698 (rank : 762)	θ value	θ > 10 (rank : 674)
Query Neighborhood Hits	185	Target Neighborhood Hits	840	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

MPP2_HUMAN
NC score	0.059692 (rank : 763)	θ value	θ > 10 (rank : 630)
Query Neighborhood Hits	185	Target Neighborhood Hits	173	Shared Neighborhood Hits	23
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

RHG25_MOUSE
NC score	0.059621 (rank : 764)	θ value	θ > 10 (rank : 782)
Query Neighborhood Hits	185	Target Neighborhood Hits	492	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

MK01_HUMAN
NC score	0.059523 (rank : 765)	θ value	θ > 10 (rank : 579)
Query Neighborhood Hits	185	Target Neighborhood Hits	836	Shared Neighborhood Hits	40
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK03_HUMAN
NC score	0.059521 (rank : 766)	θ value	θ > 10 (rank : 581)
Query Neighborhood Hits	185	Target Neighborhood Hits	837	Shared Neighborhood Hits	40
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

UN13D_HUMAN
NC score	0.059493 (rank : 767)	θ value	θ > 10 (rank : 944)
Query Neighborhood Hits	185	Target Neighborhood Hits	117	Shared Neighborhood Hits	10
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

CSK_MOUSE
NC score	0.059480 (rank : 768)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	185	Target Neighborhood Hits	1009	Shared Neighborhood Hits	50
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

RHG26_HUMAN
NC score	0.059442 (rank : 769)	θ value	θ > 10 (rank : 783)
Query Neighborhood Hits	185	Target Neighborhood Hits	281	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

MK01_MOUSE
NC score	0.059420 (rank : 770)	θ value	θ > 10 (rank : 580)
Query Neighborhood Hits	185	Target Neighborhood Hits	836	Shared Neighborhood Hits	40
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

JAK3_HUMAN
NC score	0.059087 (rank : 771)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	185	Target Neighborhood Hits	827	Shared Neighborhood Hits	40
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

K2002_MOUSE
NC score	0.059058 (rank : 772)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	185	Target Neighborhood Hits	267	Shared Neighborhood Hits	27
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

FRK_HUMAN
NC score	0.059002 (rank : 773)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	185	Target Neighborhood Hits	1058	Shared Neighborhood Hits	58
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

CLK1_HUMAN
NC score	0.058862 (rank : 774)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	185	Target Neighborhood Hits	756	Shared Neighborhood Hits	40
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

ZCH14_HUMAN
NC score	0.058736 (rank : 775)	θ value	0.279714 (rank : 71)
Query Neighborhood Hits	185	Target Neighborhood Hits	117	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WYQ9, O60324, Q9UFP0	Gene names	ZCCHC14, KIAA0579
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 14 (BDG-29).

STK16_MOUSE
NC score	0.058708 (rank : 776)	θ value	θ > 10 (rank : 856)
Query Neighborhood Hits	185	Target Neighborhood Hits	824	Shared Neighborhood Hits	40
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

KC1G2_HUMAN
NC score	0.058676 (rank : 777)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	185	Target Neighborhood Hits	693	Shared Neighborhood Hits	40
SwissProt Accessions	P78368, O00704, Q8WUB1	Gene names	CSNK1G2
Domain Architecture
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

MK12_MOUSE
NC score	0.058636 (rank : 778)	θ value	θ > 10 (rank : 598)
Query Neighborhood Hits	185	Target Neighborhood Hits	835	Shared Neighborhood Hits	40
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

CSK_HUMAN
NC score	0.058579 (rank : 779)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	185	Target Neighborhood Hits	1009	Shared Neighborhood Hits	50
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

LRRK2_MOUSE
NC score	0.058553 (rank : 780)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	185	Target Neighborhood Hits	1359	Shared Neighborhood Hits	41
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

AAK1_MOUSE
NC score	0.058548 (rank : 781)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	185	Target Neighborhood Hits	1051	Shared Neighborhood Hits	51
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

GAK_MOUSE
NC score	0.058486 (rank : 782)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	185	Target Neighborhood Hits	964	Shared Neighborhood Hits	43
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

OPHN1_HUMAN
NC score	0.058470 (rank : 783)	θ value	θ > 10 (rank : 683)
Query Neighborhood Hits	185	Target Neighborhood Hits	161	Shared Neighborhood Hits	16
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

BCR_HUMAN
NC score	0.058461 (rank : 784)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	185	Target Neighborhood Hits	204	Shared Neighborhood Hits	21
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

CLK1_MOUSE
NC score	0.058451 (rank : 785)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	185	Target Neighborhood Hits	760	Shared Neighborhood Hits	40
SwissProt Accessions	P22518	Gene names	Clk1, Clk, Sty
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY).

BMX_MOUSE
NC score	0.058390 (rank : 786)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	185	Target Neighborhood Hits	912	Shared Neighborhood Hits	41
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

KGUA_MOUSE
NC score	0.058337 (rank : 787)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	185	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

BMX_HUMAN
NC score	0.058334 (rank : 788)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	185	Target Neighborhood Hits	942	Shared Neighborhood Hits	41
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BAIP3_MOUSE
NC score	0.058332 (rank : 789)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	185	Target Neighborhood Hits	112	Shared Neighborhood Hits	10
SwissProt Accessions	Q80TT2, Q6RUT4	Gene names	Baiap3, Gm937, Kiaa0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

TEC_MOUSE
NC score	0.058327 (rank : 790)	θ value	θ > 10 (rank : 892)
Query Neighborhood Hits	185	Target Neighborhood Hits	1006	Shared Neighborhood Hits	47
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

OPHN1_MOUSE
NC score	0.058299 (rank : 791)	θ value	θ > 10 (rank : 684)
Query Neighborhood Hits	185	Target Neighborhood Hits	174	Shared Neighborhood Hits	17
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

RASL1_HUMAN
NC score	0.058083 (rank : 792)	θ value	θ > 10 (rank : 767)
Query Neighborhood Hits	185	Target Neighborhood Hits	142	Shared Neighborhood Hits	14
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

KSYK_HUMAN
NC score	0.058021 (rank : 793)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	185	Target Neighborhood Hits	901	Shared Neighborhood Hits	45
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

MK06_HUMAN
NC score	0.058015 (rank : 794)	θ value	θ > 10 (rank : 585)
Query Neighborhood Hits	185	Target Neighborhood Hits	815	Shared Neighborhood Hits	41
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

ZAP70_HUMAN
NC score	0.057958 (rank : 795)	θ value	θ > 10 (rank : 962)
Query Neighborhood Hits	185	Target Neighborhood Hits	893	Shared Neighborhood Hits	44
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

MK04_HUMAN
NC score	0.057780 (rank : 796)	θ value	θ > 10 (rank : 583)
Query Neighborhood Hits	185	Target Neighborhood Hits	837	Shared Neighborhood Hits	40
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

MOK_HUMAN
NC score	0.057706 (rank : 797)	θ value	θ > 10 (rank : 611)
Query Neighborhood Hits	185	Target Neighborhood Hits	807	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

TXK_HUMAN
NC score	0.057698 (rank : 798)	θ value	θ > 10 (rank : 929)
Query Neighborhood Hits	185	Target Neighborhood Hits	971	Shared Neighborhood Hits	44
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

NEB2_HUMAN
NC score	0.057691 (rank : 799)	θ value	θ > 10 (rank : 652)
Query Neighborhood Hits	185	Target Neighborhood Hits	883	Shared Neighborhood Hits	59
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

TEC_HUMAN
NC score	0.057661 (rank : 800)	θ value	θ > 10 (rank : 891)
Query Neighborhood Hits	185	Target Neighborhood Hits	1006	Shared Neighborhood Hits	46
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

MOK_MOUSE
NC score	0.057652 (rank : 801)	θ value	θ > 10 (rank : 612)
Query Neighborhood Hits	185	Target Neighborhood Hits	796	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

CR001_HUMAN
NC score	0.057634 (rank : 802)	θ value	2.36792 (rank : 111)
Query Neighborhood Hits	185	Target Neighborhood Hits	68	Shared Neighborhood Hits	5
SwissProt Accessions	O15165, O15166, O15167, O15168, Q6NXP3	Gene names	C18orf1
Domain Architecture
Description	Protein C18orf1.

KSYK_MOUSE
NC score	0.057615 (rank : 803)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	185	Target Neighborhood Hits	944	Shared Neighborhood Hits	47
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

CR001_MOUSE
NC score	0.057515 (rank : 804)	θ value	2.36792 (rank : 112)
Query Neighborhood Hits	185	Target Neighborhood Hits	67	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BWJ4	Gene names	D18Ertd653e
Domain Architecture	No domain graphic available
Description	Protein C18orf1 homolog.

CLK2_HUMAN
NC score	0.057456 (rank : 805)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	185	Target Neighborhood Hits	752	Shared Neighborhood Hits	40
SwissProt Accessions	P49760, Q96CQ0	Gene names	CLK2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

MK06_MOUSE
NC score	0.057402 (rank : 806)	θ value	θ > 10 (rank : 586)
Query Neighborhood Hits	185	Target Neighborhood Hits	818	Shared Neighborhood Hits	41
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

ZAP70_MOUSE
NC score	0.057385 (rank : 807)	θ value	θ > 10 (rank : 963)
Query Neighborhood Hits	185	Target Neighborhood Hits	905	Shared Neighborhood Hits	44
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

PTK6_MOUSE
NC score	0.057251 (rank : 808)	θ value	θ > 10 (rank : 757)
Query Neighborhood Hits	185	Target Neighborhood Hits	1026	Shared Neighborhood Hits	54
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

RHG12_MOUSE
NC score	0.057139 (rank : 809)	θ value	θ > 10 (rank : 780)
Query Neighborhood Hits	185	Target Neighborhood Hits	204	Shared Neighborhood Hits	13
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

FYN_HUMAN
NC score	0.056937 (rank : 810)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	185	Target Neighborhood Hits	1078	Shared Neighborhood Hits	56
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

NEB2_MOUSE
NC score	0.056821 (rank : 811)	θ value	θ > 10 (rank : 653)
Query Neighborhood Hits	185	Target Neighborhood Hits	889	Shared Neighborhood Hits	56
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

STYK1_HUMAN
NC score	0.056764 (rank : 812)	θ value	θ > 10 (rank : 877)
Query Neighborhood Hits	185	Target Neighborhood Hits	786	Shared Neighborhood Hits	40
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

KGUA_HUMAN
NC score	0.056758 (rank : 813)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	185	Target Neighborhood Hits	41	Shared Neighborhood Hits	6
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

CD2L6_MOUSE
NC score	0.056739 (rank : 814)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	185	Target Neighborhood Hits	851	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BWD8, Q80TM1	Gene names	Cdc2l6, Kiaa1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6).

RHG12_HUMAN
NC score	0.056487 (rank : 815)	θ value	θ > 10 (rank : 779)
Query Neighborhood Hits	185	Target Neighborhood Hits	190	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG25_HUMAN
NC score	0.056459 (rank : 816)	θ value	θ > 10 (rank : 781)
Query Neighborhood Hits	185	Target Neighborhood Hits	550	Shared Neighborhood Hits	29
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

PTN13_HUMAN
NC score	0.056441 (rank : 817)	θ value	θ > 10 (rank : 758)
Query Neighborhood Hits	185	Target Neighborhood Hits	471	Shared Neighborhood Hits	43
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

CD2L6_HUMAN
NC score	0.056404 (rank : 818)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	185	Target Neighborhood Hits	844	Shared Neighborhood Hits	42
SwissProt Accessions	Q9BWU1, Q5JQZ7, Q5JR00, Q8TC78, Q9UPX2	Gene names	CDC2L6, CDK11, KIAA1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11).

FES_HUMAN
NC score	0.056403 (rank : 819)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	185	Target Neighborhood Hits	978	Shared Neighborhood Hits	44
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

PTN13_MOUSE
NC score	0.056390 (rank : 820)	θ value	θ > 10 (rank : 759)
Query Neighborhood Hits	185	Target Neighborhood Hits	426	Shared Neighborhood Hits	45
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

MK04_MOUSE
NC score	0.056211 (rank : 821)	θ value	θ > 10 (rank : 584)
Query Neighborhood Hits	185	Target Neighborhood Hits	852	Shared Neighborhood Hits	40
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

GAK_HUMAN
NC score	0.056165 (rank : 822)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	185	Target Neighborhood Hits	1028	Shared Neighborhood Hits	42
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

FES_MOUSE
NC score	0.056102 (rank : 823)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	185	Target Neighborhood Hits	980	Shared Neighborhood Hits	44
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

TYK2_HUMAN
NC score	0.055998 (rank : 824)	θ value	θ > 10 (rank : 931)
Query Neighborhood Hits	185	Target Neighborhood Hits	841	Shared Neighborhood Hits	40
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

NEB1_HUMAN
NC score	0.055807 (rank : 825)	θ value	θ > 10 (rank : 651)
Query Neighborhood Hits	185	Target Neighborhood Hits	829	Shared Neighborhood Hits	56
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

CLK3_HUMAN
NC score	0.055724 (rank : 826)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	185	Target Neighborhood Hits	748	Shared Neighborhood Hits	39
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK3_MOUSE
NC score	0.055691 (rank : 827)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	185	Target Neighborhood Hits	761	Shared Neighborhood Hits	39
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

GRLF1_HUMAN
NC score	0.055600 (rank : 828)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	185	Target Neighborhood Hits	167	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

K2002_HUMAN
NC score	0.055559 (rank : 829)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	185	Target Neighborhood Hits	274	Shared Neighborhood Hits	27
SwissProt Accessions	Q9H792, Q6ZS78, Q8NCM3	Gene names	KIAA2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

CF152_HUMAN
NC score	0.055522 (rank : 830)	θ value	0.365318 (rank : 72)
Query Neighborhood Hits	185	Target Neighborhood Hits	704	Shared Neighborhood Hits	26
SwissProt Accessions	Q86VQ0, Q9BWX7	Gene names	C6orf152
Domain Architecture	No domain graphic available
Description	Protein C6orf152.

MPP6_MOUSE
NC score	0.055484 (rank : 831)	θ value	θ > 10 (rank : 639)
Query Neighborhood Hits	185	Target Neighborhood Hits	187	Shared Neighborhood Hits	20
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

CDK8_HUMAN
NC score	0.055448 (rank : 832)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	185	Target Neighborhood Hits	831	Shared Neighborhood Hits	41
SwissProt Accessions	P49336	Gene names	CDK8
Domain Architecture
Description	Cell division protein kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Protein kinase K35).

AL2S2_HUMAN
NC score	0.055397 (rank : 833)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	185	Target Neighborhood Hits	727	Shared Neighborhood Hits	40
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

MPP6_HUMAN
NC score	0.055234 (rank : 834)	θ value	θ > 10 (rank : 638)
Query Neighborhood Hits	185	Target Neighborhood Hits	180	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

CF152_MOUSE
NC score	0.055188 (rank : 835)	θ value	0.813845 (rank : 87)
Query Neighborhood Hits	185	Target Neighborhood Hits	597	Shared Neighborhood Hits	25
SwissProt Accessions	Q80ST9, Q9CYM9, Q9D5J9	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf152 homolog.

AATK_MOUSE
NC score	0.055113 (rank : 836)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	185	Target Neighborhood Hits	942	Shared Neighborhood Hits	49
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

AL2S2_MOUSE
NC score	0.055036 (rank : 837)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	185	Target Neighborhood Hits	709	Shared Neighborhood Hits	40
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

FYN_MOUSE
NC score	0.054998 (rank : 838)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	185	Target Neighborhood Hits	1073	Shared Neighborhood Hits	56
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

APBA3_MOUSE
NC score	0.054881 (rank : 839)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	185	Target Neighborhood Hits	174	Shared Neighborhood Hits	41
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

PTK6_HUMAN
NC score	0.054740 (rank : 840)	θ value	θ > 10 (rank : 756)
Query Neighborhood Hits	185	Target Neighborhood Hits	1020	Shared Neighborhood Hits	54
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

CDK9_MOUSE
NC score	0.054672 (rank : 841)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	185	Target Neighborhood Hits	822	Shared Neighborhood Hits	40
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

CLK2_MOUSE
NC score	0.054640 (rank : 842)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	185	Target Neighborhood Hits	743	Shared Neighborhood Hits	40
SwissProt Accessions	O35491	Gene names	Clk2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

CDK9_HUMAN
NC score	0.054525 (rank : 843)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	185	Target Neighborhood Hits	822	Shared Neighborhood Hits	40
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

RHG05_HUMAN
NC score	0.054480 (rank : 844)	θ value	θ > 10 (rank : 774)
Query Neighborhood Hits	185	Target Neighborhood Hits	158	Shared Neighborhood Hits	12
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RASL2_HUMAN
NC score	0.054444 (rank : 845)	θ value	θ > 10 (rank : 769)
Query Neighborhood Hits	185	Target Neighborhood Hits	161	Shared Neighborhood Hits	14
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

LYN_HUMAN
NC score	0.054240 (rank : 846)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	185	Target Neighborhood Hits	1022	Shared Neighborhood Hits	46
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

TXK_MOUSE
NC score	0.054067 (rank : 847)	θ value	θ > 10 (rank : 930)
Query Neighborhood Hits	185	Target Neighborhood Hits	980	Shared Neighborhood Hits	44
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

FA62A_HUMAN
NC score	0.053786 (rank : 848)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	185	Target Neighborhood Hits	168	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

LYN_MOUSE
NC score	0.053726 (rank : 849)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	185	Target Neighborhood Hits	1023	Shared Neighborhood Hits	46
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

ACK1_MOUSE
NC score	0.053585 (rank : 850)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	185	Target Neighborhood Hits	1080	Shared Neighborhood Hits	57
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

RHG05_MOUSE
NC score	0.053523 (rank : 851)	θ value	θ > 10 (rank : 775)
Query Neighborhood Hits	185	Target Neighborhood Hits	165	Shared Neighborhood Hits	12
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

AATK_HUMAN
NC score	0.053094 (rank : 852)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	185	Target Neighborhood Hits	1243	Shared Neighborhood Hits	53
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

STYK1_MOUSE
NC score	0.053028 (rank : 853)	θ value	θ > 10 (rank : 878)
Query Neighborhood Hits	185	Target Neighborhood Hits	779	Shared Neighborhood Hits	40
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

ITK_HUMAN
NC score	0.052967 (rank : 854)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	185	Target Neighborhood Hits	1016	Shared Neighborhood Hits	44
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
NC score	0.052914 (rank : 855)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	185	Target Neighborhood Hits	985	Shared Neighborhood Hits	43
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

RHG06_HUMAN
NC score	0.052734 (rank : 856)	θ value	θ > 10 (rank : 776)
Query Neighborhood Hits	185	Target Neighborhood Hits	114	Shared Neighborhood Hits	12
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

CLK4_MOUSE
NC score	0.052713 (rank : 857)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	185	Target Neighborhood Hits	759	Shared Neighborhood Hits	40
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

FGR_HUMAN
NC score	0.052702 (rank : 858)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	185	Target Neighborhood Hits	1067	Shared Neighborhood Hits	57
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

DOC2B_HUMAN
NC score	0.052678 (rank : 859)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	185	Target Neighborhood Hits	150	Shared Neighborhood Hits	15
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

HCK_HUMAN
NC score	0.052655 (rank : 860)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	185	Target Neighborhood Hits	1035	Shared Neighborhood Hits	48
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

ITSN2_HUMAN
NC score	0.052547 (rank : 861)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	185	Target Neighborhood Hits	1173	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

TYK2_MOUSE
NC score	0.052538 (rank : 862)	θ value	θ > 10 (rank : 932)
Query Neighborhood Hits	185	Target Neighborhood Hits	850	Shared Neighborhood Hits	40
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

SYTL2_HUMAN
NC score	0.052308 (rank : 863)	θ value	θ > 10 (rank : 880)
Query Neighborhood Hits	185	Target Neighborhood Hits	248	Shared Neighborhood Hits	14
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

MET_MOUSE
NC score	0.052295 (rank : 864)	θ value	θ > 10 (rank : 576)
Query Neighborhood Hits	185	Target Neighborhood Hits	844	Shared Neighborhood Hits	41
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

CLK4_HUMAN
NC score	0.052289 (rank : 865)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	185	Target Neighborhood Hits	759	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HAZ1	Gene names	CLK4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

MATK_MOUSE
NC score	0.052277 (rank : 866)	θ value	θ > 10 (rank : 572)
Query Neighborhood Hits	185	Target Neighborhood Hits	952	Shared Neighborhood Hits	46
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

CI096_HUMAN
NC score	0.052164 (rank : 867)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	185	Target Neighborhood Hits	821	Shared Neighborhood Hits	40
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

MATK_HUMAN
NC score	0.052055 (rank : 868)	θ value	θ > 10 (rank : 571)
Query Neighborhood Hits	185	Target Neighborhood Hits	954	Shared Neighborhood Hits	46
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

DOC2B_MOUSE
NC score	0.052050 (rank : 869)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	185	Target Neighborhood Hits	169	Shared Neighborhood Hits	16
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

TIE2_HUMAN
NC score	0.052012 (rank : 870)	θ value	θ > 10 (rank : 897)
Query Neighborhood Hits	185	Target Neighborhood Hits	1192	Shared Neighborhood Hits	44
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

JAK2_MOUSE
NC score	0.051950 (rank : 871)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	185	Target Neighborhood Hits	839	Shared Neighborhood Hits	40
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_HUMAN
NC score	0.051866 (rank : 872)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	185	Target Neighborhood Hits	847	Shared Neighborhood Hits	40
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

LCK_MOUSE
NC score	0.051819 (rank : 873)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	185	Target Neighborhood Hits	981	Shared Neighborhood Hits	48
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

TIE2_MOUSE
NC score	0.051805 (rank : 874)	θ value	θ > 10 (rank : 898)
Query Neighborhood Hits	185	Target Neighborhood Hits	1204	Shared Neighborhood Hits	44
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

KC1E_MOUSE
NC score	0.051730 (rank : 875)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	185	Target Neighborhood Hits	728	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1E_HUMAN
NC score	0.051728 (rank : 876)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	185	Target Neighborhood Hits	732	Shared Neighborhood Hits	40
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

HCK_MOUSE
NC score	0.051595 (rank : 877)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	185	Target Neighborhood Hits	1029	Shared Neighborhood Hits	47
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

RHG06_MOUSE
NC score	0.051594 (rank : 878)	θ value	θ > 10 (rank : 777)
Query Neighborhood Hits	185	Target Neighborhood Hits	105	Shared Neighborhood Hits	10
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

BLK_HUMAN
NC score	0.051239 (rank : 879)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	185	Target Neighborhood Hits	994	Shared Neighborhood Hits	48
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

TYRO3_MOUSE
NC score	0.051149 (rank : 880)	θ value	θ > 10 (rank : 934)
Query Neighborhood Hits	185	Target Neighborhood Hits	1007	Shared Neighborhood Hits	39
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

PDLI2_HUMAN
NC score	0.051110 (rank : 881)	θ value	θ > 10 (rank : 711)
Query Neighborhood Hits	185	Target Neighborhood Hits	245	Shared Neighborhood Hits	38
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

FAK2_MOUSE
NC score	0.051072 (rank : 882)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	185	Target Neighborhood Hits	851	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

SRGP1_HUMAN
NC score	0.051040 (rank : 883)	θ value	θ > 10 (rank : 839)
Query Neighborhood Hits	185	Target Neighborhood Hits	390	Shared Neighborhood Hits	31
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

RHG04_HUMAN
NC score	0.050970 (rank : 884)	θ value	θ > 10 (rank : 773)
Query Neighborhood Hits	185	Target Neighborhood Hits	307	Shared Neighborhood Hits	24
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

FAK2_HUMAN
NC score	0.050962 (rank : 885)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	185	Target Neighborhood Hits	847	Shared Neighborhood Hits	40
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

TYRO3_HUMAN
NC score	0.050958 (rank : 886)	θ value	θ > 10 (rank : 933)
Query Neighborhood Hits	185	Target Neighborhood Hits	995	Shared Neighborhood Hits	39
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

FNBP2_HUMAN
NC score	0.050851 (rank : 887)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	185	Target Neighborhood Hits	432	Shared Neighborhood Hits	33
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

TTBK1_HUMAN
NC score	0.050825 (rank : 888)	θ value	θ > 10 (rank : 924)
Query Neighborhood Hits	185	Target Neighborhood Hits	1058	Shared Neighborhood Hits	49
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

KC1D_HUMAN
NC score	0.050814 (rank : 889)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	185	Target Neighborhood Hits	737	Shared Neighborhood Hits	40
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
NC score	0.050813 (rank : 890)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	185	Target Neighborhood Hits	737	Shared Neighborhood Hits	40
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

SRC_HUMAN
NC score	0.050807 (rank : 891)	θ value	θ > 10 (rank : 838)
Query Neighborhood Hits	185	Target Neighborhood Hits	1058	Shared Neighborhood Hits	56
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

BUB1_MOUSE
NC score	0.050804 (rank : 892)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	185	Target Neighborhood Hits	583	Shared Neighborhood Hits	38
SwissProt Accessions	O08901, O09007	Gene names	Bub1
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (MBUB1) (BUB1A).

ANKK1_MOUSE
NC score	0.050651 (rank : 893)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	185	Target Neighborhood Hits	1072	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

JAK1_HUMAN
NC score	0.050631 (rank : 894)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	185	Target Neighborhood Hits	858	Shared Neighborhood Hits	41
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

SRMS_MOUSE
NC score	0.050473 (rank : 895)	θ value	θ > 10 (rank : 840)
Query Neighborhood Hits	185	Target Neighborhood Hits	964	Shared Neighborhood Hits	45
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

MET_HUMAN
NC score	0.050457 (rank : 896)	θ value	θ > 10 (rank : 575)
Query Neighborhood Hits	185	Target Neighborhood Hits	831	Shared Neighborhood Hits	40
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

ARHG1_MOUSE
NC score	0.050447 (rank : 897)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	185	Target Neighborhood Hits	266	Shared Neighborhood Hits	12
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

NCOA6_MOUSE
NC score	0.050338 (rank : 898)	θ value	0.813845 (rank : 92)
Query Neighborhood Hits	185	Target Neighborhood Hits	1076	Shared Neighborhood Hits	33
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

ARHG1_HUMAN
NC score	0.050230 (rank : 899)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	185	Target Neighborhood Hits	176	Shared Neighborhood Hits	10
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

RIPK4_HUMAN
NC score	0.050221 (rank : 900)	θ value	θ > 10 (rank : 795)
Query Neighborhood Hits	185	Target Neighborhood Hits	1094	Shared Neighborhood Hits	41
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

ITSN1_MOUSE
NC score	0.050125 (rank : 901)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	185	Target Neighborhood Hits	1669	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

RP3A_HUMAN
NC score	0.050086 (rank : 902)	θ value	θ > 10 (rank : 801)
Query Neighborhood Hits	185	Target Neighborhood Hits	305	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

LBC_HUMAN
NC score	0.050063 (rank : 903)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	185	Target Neighborhood Hits	90	Shared Neighborhood Hits	10
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

NCOA6_HUMAN
NC score	0.049452 (rank : 904)	θ value	1.81305 (rank : 106)
Query Neighborhood Hits	185	Target Neighborhood Hits	1202	Shared Neighborhood Hits	39
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

ACINU_MOUSE
NC score	0.048933 (rank : 905)	θ value	3.0926 (rank : 121)
Query Neighborhood Hits	185	Target Neighborhood Hits	712	Shared Neighborhood Hits	37
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

MYF6_MOUSE
NC score	0.048797 (rank : 906)	θ value	0.279714 (rank : 66)
Query Neighborhood Hits	185	Target Neighborhood Hits	72	Shared Neighborhood Hits	2
SwissProt Accessions	P15375	Gene names	Myf6, Myf-6
Domain Architecture
Description	Myogenic factor 6 (Myf-6) (Herculin).

ASPP1_MOUSE
NC score	0.046156 (rank : 907)	θ value	0.279714 (rank : 63)
Query Neighborhood Hits	185	Target Neighborhood Hits	1244	Shared Neighborhood Hits	47
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

CS007_MOUSE
NC score	0.041471 (rank : 908)	θ value	1.38821 (rank : 95)
Query Neighborhood Hits	185	Target Neighborhood Hits	464	Shared Neighborhood Hits	14
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

DPOG1_HUMAN
NC score	0.041157 (rank : 909)	θ value	2.36792 (rank : 113)
Query Neighborhood Hits	185	Target Neighborhood Hits	28	Shared Neighborhood Hits	4
SwissProt Accessions	P54098, Q8NFM2, Q92515	Gene names	POLG, MDP1, POLG1, POLGA
Domain Architecture
Description	DNA polymerase subunit gamma 1 (EC 2.7.7.7) (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha).

SDC3_MOUSE
NC score	0.039724 (rank : 910)	θ value	2.36792 (rank : 118)
Query Neighborhood Hits	185	Target Neighborhood Hits	107	Shared Neighborhood Hits	7
SwissProt Accessions	Q64519, Q3UDD9, Q6ZQA4, Q7TQD4	Gene names	Sdc3, Kiaa0468
Domain Architecture
Description	Syndecan-3 precursor (SYND3).

HRX_HUMAN
NC score	0.038579 (rank : 911)	θ value	1.81305 (rank : 103)
Query Neighborhood Hits	185	Target Neighborhood Hits	825	Shared Neighborhood Hits	33
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

LR37A_HUMAN
NC score	0.035742 (rank : 912)	θ value	0.813845 (rank : 88)
Query Neighborhood Hits	185	Target Neighborhood Hits	720	Shared Neighborhood Hits	27
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

DPOG1_MOUSE
NC score	0.035037 (rank : 913)	θ value	6.88961 (rank : 159)
Query Neighborhood Hits	185	Target Neighborhood Hits	26	Shared Neighborhood Hits	5
SwissProt Accessions	P54099, Q9JI28	Gene names	Polg, Polg1
Domain Architecture
Description	DNA polymerase subunit gamma 1 (EC 2.7.7.7) (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha).

PKCB1_HUMAN
NC score	0.033955 (rank : 914)	θ value	4.03905 (rank : 137)
Query Neighborhood Hits	185	Target Neighborhood Hits	488	Shared Neighborhood Hits	22
SwissProt Accessions	Q9ULU4, Q13517, Q4JJ94, Q4JJ95, Q5TH09, Q6MZM1, Q8WXC5, Q9H1F3, Q9H1F4, Q9H1F5, Q9H1L8, Q9H1L9, Q9H2G5, Q9NYN3, Q9UIX6	Gene names	PRKCBP1, KIAA1125, RACK7, ZMYND8
Domain Architecture
Description	Protein kinase C-binding protein 1 (Rack7) (Cutaneous T-cell lymphoma- associated antigen se14-3) (CTCL tumor antigen se14-3) (Zinc finger MYND domain-containing protein 8).

HIP1R_HUMAN
NC score	0.033582 (rank : 915)	θ value	3.0926 (rank : 126)
Query Neighborhood Hits	185	Target Neighborhood Hits	809	Shared Neighborhood Hits	28
SwissProt Accessions	O75146, Q9UED9	Gene names	HIP1R, HIP12, KIAA0655
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related) (Hip 12).

ECM1_HUMAN
NC score	0.033350 (rank : 916)	θ value	5.27518 (rank : 145)
Query Neighborhood Hits	185	Target Neighborhood Hits	182	Shared Neighborhood Hits	12
SwissProt Accessions	Q16610	Gene names	ECM1
Domain Architecture
Description	Extracellular matrix protein 1 precursor (Secretory component p85).

YO11_MOUSE
NC score	0.033276 (rank : 917)	θ value	5.27518 (rank : 152)
Query Neighborhood Hits	185	Target Neighborhood Hits	272	Shared Neighborhood Hits	14
SwissProt Accessions	P11260	Gene names
Domain Architecture
Description	Hypothetical protein ORF-1137.

CKAP4_MOUSE
NC score	0.032897 (rank : 918)	θ value	5.27518 (rank : 141)
Query Neighborhood Hits	185	Target Neighborhood Hits	596	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BMK4, Q8BTK8, Q8R3F2	Gene names	Ckap4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

LIPA1_HUMAN
NC score	0.032846 (rank : 919)	θ value	0.62314 (rank : 81)
Query Neighborhood Hits	185	Target Neighborhood Hits	1294	Shared Neighborhood Hits	33
SwissProt Accessions	Q13136, Q13135, Q14567, Q8N4I2	Gene names	PPFIA1, LIP1
Domain Architecture
Description	Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) (LAR-interacting protein 1) (LIP.1).

HIP1R_MOUSE
NC score	0.032313 (rank : 920)	θ value	5.27518 (rank : 146)
Query Neighborhood Hits	185	Target Neighborhood Hits	959	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JKY5	Gene names	Hip1r
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related).

LBXCO_HUMAN
NC score	0.031128 (rank : 921)	θ value	5.27518 (rank : 147)
Query Neighborhood Hits	185	Target Neighborhood Hits	167	Shared Neighborhood Hits	11
SwissProt Accessions	P84550	Gene names	LBXCOR1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1.

LBXCO_MOUSE
NC score	0.030118 (rank : 922)	θ value	5.27518 (rank : 148)
Query Neighborhood Hits	185	Target Neighborhood Hits	140	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BX46, Q3UYA4, Q5W8I2, Q8C0T2	Gene names	Lbxcor1, Corl1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1 (Transcriptional corepressor Corl1).

EP15R_MOUSE
NC score	0.029628 (rank : 923)	θ value	1.38821 (rank : 96)
Query Neighborhood Hits	185	Target Neighborhood Hits	1135	Shared Neighborhood Hits	35
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

LIPA2_HUMAN
NC score	0.029627 (rank : 924)	θ value	5.27518 (rank : 149)
Query Neighborhood Hits	185	Target Neighborhood Hits	1044	Shared Neighborhood Hits	29
SwissProt Accessions	O75334	Gene names	PPFIA2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

TXLNB_HUMAN
NC score	0.029332 (rank : 925)	θ value	8.99809 (rank : 185)
Query Neighborhood Hits	185	Target Neighborhood Hits	912	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

NFH_MOUSE
NC score	0.028681 (rank : 926)	θ value	0.279714 (rank : 67)
Query Neighborhood Hits	185	Target Neighborhood Hits	2247	Shared Neighborhood Hits	58
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

OSTP_HUMAN
NC score	0.028207 (rank : 927)	θ value	8.99809 (rank : 183)
Query Neighborhood Hits	185	Target Neighborhood Hits	36	Shared Neighborhood Hits	5
SwissProt Accessions	P10451, Q15681, Q15682, Q15683, Q8NBK2, Q96IZ1	Gene names	SPP1, OPN
Domain Architecture
Description	Osteopontin precursor (Bone sialoprotein-1) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Nephropontin) (Uropontin).

GA2L2_HUMAN
NC score	0.027771 (rank : 928)	θ value	4.03905 (rank : 135)
Query Neighborhood Hits	185	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NHY3, Q8NHY4	Gene names	GAS2L2, GAR17
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2) (GAS2-related protein on chromosome 17) (GAR17 protein).

MYH10_MOUSE
NC score	0.026880 (rank : 929)	θ value	6.88961 (rank : 164)
Query Neighborhood Hits	185	Target Neighborhood Hits	1612	Shared Neighborhood Hits	35
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH10_HUMAN
NC score	0.026680 (rank : 930)	θ value	8.99809 (rank : 181)
Query Neighborhood Hits	185	Target Neighborhood Hits	1620	Shared Neighborhood Hits	35
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

TPR_HUMAN
NC score	0.025768 (rank : 931)	θ value	1.38821 (rank : 100)
Query Neighborhood Hits	185	Target Neighborhood Hits	1921	Shared Neighborhood Hits	40
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

CEP63_HUMAN
NC score	0.025482 (rank : 932)	θ value	4.03905 (rank : 133)
Query Neighborhood Hits	185	Target Neighborhood Hits	1005	Shared Neighborhood Hits	28
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

CCHCR_MOUSE
NC score	0.024783 (rank : 933)	θ value	6.88961 (rank : 156)
Query Neighborhood Hits	185	Target Neighborhood Hits	932	Shared Neighborhood Hits	30
SwissProt Accessions	Q8K2I2	Gene names	Cchcr1, Hcr
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein).

HERC2_MOUSE
NC score	0.024418 (rank : 934)	θ value	1.38821 (rank : 97)
Query Neighborhood Hits	185	Target Neighborhood Hits	167	Shared Neighborhood Hits	6
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

DAB1_HUMAN
NC score	0.023998 (rank : 935)	θ value	4.03905 (rank : 134)
Query Neighborhood Hits	185	Target Neighborhood Hits	219	Shared Neighborhood Hits	10
SwissProt Accessions	O75553, Q9NYA8	Gene names	DAB1
Domain Architecture
Description	Disabled homolog 1.

CT2NL_HUMAN
NC score	0.023837 (rank : 936)	θ value	5.27518 (rank : 142)
Query Neighborhood Hits	185	Target Neighborhood Hits	1059	Shared Neighborhood Hits	30
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

CENPF_HUMAN
NC score	0.022494 (rank : 937)	θ value	5.27518 (rank : 140)
Query Neighborhood Hits	185	Target Neighborhood Hits	1932	Shared Neighborhood Hits	37
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

GAK4_HUMAN
NC score	0.021978 (rank : 938)	θ value	3.0926 (rank : 125)
Query Neighborhood Hits	185	Target Neighborhood Hits	415	Shared Neighborhood Hits	16
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

TBC10_MOUSE
NC score	0.021078 (rank : 939)	θ value	3.0926 (rank : 129)
Query Neighborhood Hits	185	Target Neighborhood Hits	94	Shared Neighborhood Hits	4
SwissProt Accessions	P58802	Gene names	Tbc1d10a, Epi64, Tbc1d10
Domain Architecture
Description	TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein).

SC24C_HUMAN
NC score	0.020192 (rank : 940)	θ value	6.88961 (rank : 167)
Query Neighborhood Hits	185	Target Neighborhood Hits	662	Shared Neighborhood Hits	19
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

GAK11_HUMAN
NC score	0.019814 (rank : 941)	θ value	6.88961 (rank : 160)
Query Neighborhood Hits	185	Target Neighborhood Hits	409	Shared Neighborhood Hits	16
SwissProt Accessions	P63145, Q9UKI1	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_22q11.21 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K101 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

K1802_HUMAN
NC score	0.019737 (rank : 942)	θ value	6.88961 (rank : 163)
Query Neighborhood Hits	185	Target Neighborhood Hits	1378	Shared Neighborhood Hits	37
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

GAK2_HUMAN
NC score	0.019475 (rank : 943)	θ value	6.88961 (rank : 161)
Query Neighborhood Hits	185	Target Neighborhood Hits	406	Shared Neighborhood Hits	17
SwissProt Accessions	Q7LDI9, Q9UKH5, Q9Y6I1, Q9YNA6, Q9YNB0	Gene names	ERVK6
Domain Architecture	No domain graphic available
Description	HERV-K_7p22.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K(C7) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

HERC2_HUMAN
NC score	0.019443 (rank : 944)	θ value	6.88961 (rank : 162)
Query Neighborhood Hits	185	Target Neighborhood Hits	163	Shared Neighborhood Hits	4
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

GA2L2_MOUSE
NC score	0.019367 (rank : 945)	θ value	8.99809 (rank : 177)
Query Neighborhood Hits	185	Target Neighborhood Hits	395	Shared Neighborhood Hits	11
SwissProt Accessions	Q5SSG4	Gene names	Gas2l2
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2).

GAK5_HUMAN
NC score	0.018918 (rank : 946)	θ value	8.99809 (rank : 178)
Query Neighborhood Hits	185	Target Neighborhood Hits	429	Shared Neighborhood Hits	16
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

DDX11_HUMAN
NC score	0.018869 (rank : 947)	θ value	6.88961 (rank : 157)
Query Neighborhood Hits	185	Target Neighborhood Hits	124	Shared Neighborhood Hits	10
SwissProt Accessions	Q96FC9, Q13333, Q86VQ4, Q86W62, Q92498, Q92770, Q92998, Q92999	Gene names	DDX11, CHL1, CHLR1, KRG2
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX11 (EC 3.6.1.-) (DEAD/H box protein 11) (CHL1 homolog) (Keratinocyte growth factor-regulated gene 2 protein) (KRG-2).

MUC5B_HUMAN
NC score	0.018739 (rank : 948)	θ value	2.36792 (rank : 115)
Query Neighborhood Hits	185	Target Neighborhood Hits	1020	Shared Neighborhood Hits	17
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

SETB1_MOUSE
NC score	0.018709 (rank : 949)	θ value	6.88961 (rank : 168)
Query Neighborhood Hits	185	Target Neighborhood Hits	150	Shared Neighborhood Hits	14
SwissProt Accessions	O88974, Q922K1	Gene names	Setdb1, Eset
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (SET domain bifurcated 1) (ERG-associated protein with SET domain) (ESET).

MKL1_MOUSE
NC score	0.017513 (rank : 950)	θ value	8.99809 (rank : 180)
Query Neighborhood Hits	185	Target Neighborhood Hits	667	Shared Neighborhood Hits	20
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

FA5_HUMAN
NC score	0.016025 (rank : 951)	θ value	3.0926 (rank : 124)
Query Neighborhood Hits	185	Target Neighborhood Hits	172	Shared Neighborhood Hits	4
SwissProt Accessions	P12259, Q14285, Q6UPU6	Gene names	F5
Domain Architecture
Description	Coagulation factor V precursor (Activated protein C cofactor) [Contains: Coagulation factor V heavy chain; Coagulation factor V light chain].

FA61B_MOUSE
NC score	0.014496 (rank : 952)	θ value	8.99809 (rank : 176)
Query Neighborhood Hits	185	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CGC4	Gene names	Fam61b
Domain Architecture	No domain graphic available
Description	Protein FAM61B.

USP9X_MOUSE
NC score	0.014037 (rank : 953)	θ value	6.88961 (rank : 171)
Query Neighborhood Hits	185	Target Neighborhood Hits	171	Shared Neighborhood Hits	4
SwissProt Accessions	P70398, Q62497	Gene names	Usp9x, Fafl, Fam
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein-related, X- linked) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin carboxyl-terminal hydrolase FAM) (Fat facets homolog).

USP9X_HUMAN
NC score	0.013889 (rank : 954)	θ value	6.88961 (rank : 170)
Query Neighborhood Hits	185	Target Neighborhood Hits	161	Shared Neighborhood Hits	6
SwissProt Accessions	Q93008, O75550, Q8WWT3, Q8WX12	Gene names	USP9X, DFFRX, USP9
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein-related, X- linked) (Ubiquitin-specific protease 9, X chromosome).

LTB1L_MOUSE
NC score	0.013136 (rank : 955)	θ value	1.81305 (rank : 104)
Query Neighborhood Hits	185	Target Neighborhood Hits	514	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CG19, O88349, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTB1S_MOUSE
NC score	0.012965 (rank : 956)	θ value	1.81305 (rank : 105)
Query Neighborhood Hits	185	Target Neighborhood Hits	479	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CG18, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

TRI62_HUMAN
NC score	0.010801 (rank : 957)	θ value	4.03905 (rank : 139)
Query Neighborhood Hits	185	Target Neighborhood Hits	584	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BVG3, Q9NVG0	Gene names	TRIM62
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 62.

ESAM_HUMAN
NC score	0.008903 (rank : 958)	θ value	8.99809 (rank : 175)
Query Neighborhood Hits	185	Target Neighborhood Hits	251	Shared Neighborhood Hits	3
SwissProt Accessions	Q96AP7, Q96T50	Gene names	ESAM
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

STAB2_MOUSE
NC score	0.007297 (rank : 959)	θ value	6.88961 (rank : 169)
Query Neighborhood Hits	185	Target Neighborhood Hits	528	Shared Neighborhood Hits	10
SwissProt Accessions	Q8R4U0, Q8BM87	Gene names	Stab2
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor [Contains: Short form stabilin-2].

ADA2A_MOUSE
NC score	0.003762 (rank : 960)	θ value	0.813845 (rank : 86)
Query Neighborhood Hits	185	Target Neighborhood Hits	900	Shared Neighborhood Hits	3
SwissProt Accessions	Q01338	Gene names	Adra2a
Domain Architecture
Description	Alpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2A adrenoreceptor) (Alpha-2AAR).

C1RA_MOUSE
NC score	0.002918 (rank : 961)	θ value	8.99809 (rank : 173)
Query Neighborhood Hits	185	Target Neighborhood Hits	379	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CG16, Q99KI6, Q9ET60	Gene names	C1ra, C1r
Domain Architecture
Description	Complement C1r-A subcomponent precursor (EC 3.4.21.41) (Complement component 1, r-A subcomponent) [Contains: Complement C1r-A subcomponent heavy chain; Complement C1r-A subcomponent light chain].

C1RB_MOUSE
NC score	0.002811 (rank : 962)	θ value	8.99809 (rank : 174)
Query Neighborhood Hits	185	Target Neighborhood Hits	380	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CFG9	Gene names	C1rb, C1r
Domain Architecture	No domain graphic available
Description	Complement C1r-B subcomponent precursor (EC 3.4.21.41) (Complement component 1, r-B subcomponent) [Contains: Complement C1r-B subcomponent heavy chain; Complement C1r-B subcomponent light chain].

GLIS1_HUMAN
NC score	0.000951 (rank : 963)	θ value	2.36792 (rank : 114)
Query Neighborhood Hits	185	Target Neighborhood Hits	748	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NBF1, Q8N9V9	Gene names	GLIS1
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS1 (GLI-similar 1).

MYNN_HUMAN
NC score	-0.002377 (rank : 964)	θ value	3.0926 (rank : 127)
Query Neighborhood Hits	185	Target Neighborhood Hits	826	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NPC7, Q6QHA6, Q6QHA7, Q6R3G1, Q6R3G2, Q6R4A0, Q7Z716, Q7Z717, Q86Z11, Q86Z12, Q9NS01, Q9UIW8	Gene names	MYNN, OSZF, ZBTB31
Domain Architecture	No domain graphic available
Description	Myoneurin (Zinc finger and BTB domain-containing protein 31).

ZBT16_HUMAN
NC score	-0.002806 (rank : 965)	θ value	5.27518 (rank : 153)
Query Neighborhood Hits	185	Target Neighborhood Hits	1010	Shared Neighborhood Hits	7
SwissProt Accessions	Q05516, Q8TAL4	Gene names	ZBTB16, PLZF, ZNF145
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 16 (Zinc finger protein PLZF) (Promyelocytic leukemia zinc finger protein) (Zinc finger protein 145).