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Network neighborhood for query Sequence : ARHG2_HUMAN

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ARHG2_HUMAN
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ARHG2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	142	Target Neighborhood Hits	142	Shared Neighborhood Hits	142
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	0 (rank : 2)	NC score	0.981347 (rank : 2)
Query Neighborhood Hits	142	Target Neighborhood Hits	120	Shared Neighborhood Hits	97
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

RGNEF_MOUSE
θ value	1.86652e-130 (rank : 3)	NC score	0.803504 (rank : 5)
Query Neighborhood Hits	142	Target Neighborhood Hits	641	Shared Neighborhood Hits	96
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

LBC_HUMAN
θ value	2.29227e-112 (rank : 4)	NC score	0.942818 (rank : 3)
Query Neighborhood Hits	142	Target Neighborhood Hits	90	Shared Neighborhood Hits	56
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHGB_HUMAN
θ value	4.71619e-41 (rank : 5)	NC score	0.754746 (rank : 9)
Query Neighborhood Hits	142	Target Neighborhood Hits	375	Shared Neighborhood Hits	62
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	3.05695e-40 (rank : 6)	NC score	0.758059 (rank : 8)
Query Neighborhood Hits	142	Target Neighborhood Hits	351	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	3.05695e-40 (rank : 7)	NC score	0.758780 (rank : 7)
Query Neighborhood Hits	142	Target Neighborhood Hits	344	Shared Neighborhood Hits	63
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHG1_HUMAN
θ value	2.67802e-36 (rank : 8)	NC score	0.819421 (rank : 4)
Query Neighborhood Hits	142	Target Neighborhood Hits	176	Shared Neighborhood Hits	59
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	6.59618e-35 (rank : 9)	NC score	0.800198 (rank : 6)
Query Neighborhood Hits	142	Target Neighborhood Hits	266	Shared Neighborhood Hits	54
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ITSN2_HUMAN
θ value	6.20254e-17 (rank : 10)	NC score	0.444746 (rank : 38)
Query Neighborhood Hits	142	Target Neighborhood Hits	1173	Shared Neighborhood Hits	93
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN1_HUMAN
θ value	2.60593e-15 (rank : 11)	NC score	0.408380 (rank : 45)
Query Neighborhood Hits	142	Target Neighborhood Hits	1757	Shared Neighborhood Hits	103
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN2_MOUSE
θ value	5.8054e-15 (rank : 12)	NC score	0.421538 (rank : 42)
Query Neighborhood Hits	142	Target Neighborhood Hits	1371	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

FGD3_MOUSE
θ value	2.20605e-14 (rank : 13)	NC score	0.561352 (rank : 22)
Query Neighborhood Hits	142	Target Neighborhood Hits	257	Shared Neighborhood Hits	65
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

ITSN1_MOUSE
θ value	4.91457e-14 (rank : 14)	NC score	0.405795 (rank : 46)
Query Neighborhood Hits	142	Target Neighborhood Hits	1669	Shared Neighborhood Hits	104
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

FGD3_HUMAN
θ value	9.26847e-13 (rank : 15)	NC score	0.530790 (rank : 24)
Query Neighborhood Hits	142	Target Neighborhood Hits	249	Shared Neighborhood Hits	63
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD4_MOUSE
θ value	6.00763e-12 (rank : 16)	NC score	0.519678 (rank : 27)
Query Neighborhood Hits	142	Target Neighborhood Hits	227	Shared Neighborhood Hits	63
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

ARHG3_HUMAN
θ value	1.02475e-11 (rank : 17)	NC score	0.659849 (rank : 10)
Query Neighborhood Hits	142	Target Neighborhood Hits	82	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG8_MOUSE
θ value	1.74796e-11 (rank : 18)	NC score	0.628003 (rank : 14)
Query Neighborhood Hits	142	Target Neighborhood Hits	79	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

FGD4_HUMAN
θ value	1.74796e-11 (rank : 19)	NC score	0.521134 (rank : 26)
Query Neighborhood Hits	142	Target Neighborhood Hits	219	Shared Neighborhood Hits	63
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

ARHG3_MOUSE
θ value	2.28291e-11 (rank : 20)	NC score	0.659220 (rank : 11)
Query Neighborhood Hits	142	Target Neighborhood Hits	85	Shared Neighborhood Hits	60
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHGG_HUMAN
θ value	1.133e-10 (rank : 21)	NC score	0.638909 (rank : 12)
Query Neighborhood Hits	142	Target Neighborhood Hits	129	Shared Neighborhood Hits	62
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

FGD1_MOUSE
θ value	2.52405e-10 (rank : 22)	NC score	0.512611 (rank : 30)
Query Neighborhood Hits	142	Target Neighborhood Hits	387	Shared Neighborhood Hits	68
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ARHG8_HUMAN
θ value	3.29651e-10 (rank : 23)	NC score	0.633709 (rank : 13)
Query Neighborhood Hits	142	Target Neighborhood Hits	85	Shared Neighborhood Hits	61
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

FARP2_MOUSE
θ value	9.59137e-10 (rank : 24)	NC score	0.332994 (rank : 56)
Query Neighborhood Hits	142	Target Neighborhood Hits	209	Shared Neighborhood Hits	59
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

PREX1_HUMAN
θ value	9.59137e-10 (rank : 25)	NC score	0.534354 (rank : 23)
Query Neighborhood Hits	142	Target Neighborhood Hits	177	Shared Neighborhood Hits	62
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

FGD1_HUMAN
θ value	1.63604e-09 (rank : 26)	NC score	0.507441 (rank : 31)
Query Neighborhood Hits	142	Target Neighborhood Hits	367	Shared Neighborhood Hits	68
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_MOUSE
θ value	4.76016e-09 (rank : 27)	NC score	0.524435 (rank : 25)
Query Neighborhood Hits	142	Target Neighborhood Hits	163	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

VAV2_HUMAN
θ value	1.38499e-08 (rank : 28)	NC score	0.428220 (rank : 40)
Query Neighborhood Hits	142	Target Neighborhood Hits	453	Shared Neighborhood Hits	86
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ARHG5_HUMAN
θ value	2.36244e-08 (rank : 29)	NC score	0.606247 (rank : 16)
Query Neighborhood Hits	142	Target Neighborhood Hits	172	Shared Neighborhood Hits	63
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

FGD2_HUMAN
θ value	4.0297e-08 (rank : 30)	NC score	0.514917 (rank : 28)
Query Neighborhood Hits	142	Target Neighborhood Hits	151	Shared Neighborhood Hits	64
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

ARHGF_HUMAN
θ value	5.26297e-08 (rank : 31)	NC score	0.574332 (rank : 20)
Query Neighborhood Hits	142	Target Neighborhood Hits	214	Shared Neighborhood Hits	58
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

NGEF_HUMAN
θ value	6.87365e-08 (rank : 32)	NC score	0.581964 (rank : 17)
Query Neighborhood Hits	142	Target Neighborhood Hits	166	Shared Neighborhood Hits	61
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	8.97725e-08 (rank : 33)	NC score	0.574491 (rank : 19)
Query Neighborhood Hits	142	Target Neighborhood Hits	228	Shared Neighborhood Hits	61
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHGG_MOUSE
θ value	1.17247e-07 (rank : 34)	NC score	0.615913 (rank : 15)
Query Neighborhood Hits	142	Target Neighborhood Hits	152	Shared Neighborhood Hits	61
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

VAV2_MOUSE
θ value	1.53129e-07 (rank : 35)	NC score	0.422787 (rank : 41)
Query Neighborhood Hits	142	Target Neighborhood Hits	456	Shared Neighborhood Hits	83
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ECT2_MOUSE
θ value	2.61198e-07 (rank : 36)	NC score	0.576935 (rank : 18)
Query Neighborhood Hits	142	Target Neighborhood Hits	98	Shared Neighborhood Hits	63
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_HUMAN
θ value	4.45536e-07 (rank : 37)	NC score	0.563841 (rank : 21)
Query Neighborhood Hits	142	Target Neighborhood Hits	98	Shared Neighborhood Hits	62
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

FARP1_HUMAN
θ value	4.45536e-07 (rank : 38)	NC score	0.304874 (rank : 59)
Query Neighborhood Hits	142	Target Neighborhood Hits	241	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

TIAM1_MOUSE
θ value	1.29631e-06 (rank : 39)	NC score	0.514879 (rank : 29)
Query Neighborhood Hits	142	Target Neighborhood Hits	205	Shared Neighborhood Hits	61
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

VAV_MOUSE
θ value	1.69304e-06 (rank : 40)	NC score	0.418520 (rank : 43)
Query Neighborhood Hits	142	Target Neighborhood Hits	430	Shared Neighborhood Hits	86
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

TIAM1_HUMAN
θ value	3.77169e-06 (rank : 41)	NC score	0.503914 (rank : 32)
Query Neighborhood Hits	142	Target Neighborhood Hits	225	Shared Neighborhood Hits	62
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

DNMBP_MOUSE
θ value	8.40245e-06 (rank : 42)	NC score	0.412549 (rank : 44)
Query Neighborhood Hits	142	Target Neighborhood Hits	435	Shared Neighborhood Hits	70
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_HUMAN
θ value	1.87187e-05 (rank : 43)	NC score	0.403207 (rank : 47)
Query Neighborhood Hits	142	Target Neighborhood Hits	413	Shared Neighborhood Hits	72
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

VAV_HUMAN
θ value	4.1701e-05 (rank : 44)	NC score	0.400352 (rank : 49)
Query Neighborhood Hits	142	Target Neighborhood Hits	452	Shared Neighborhood Hits	86
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

MCF2_HUMAN
θ value	0.000121331 (rank : 45)	NC score	0.438015 (rank : 39)
Query Neighborhood Hits	142	Target Neighborhood Hits	166	Shared Neighborhood Hits	66
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ARHG4_HUMAN
θ value	0.000158464 (rank : 46)	NC score	0.469091 (rank : 36)
Query Neighborhood Hits	142	Target Neighborhood Hits	242	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

KPCT_MOUSE
θ value	0.00020696 (rank : 47)	NC score	0.046883 (rank : 216)
Query Neighborhood Hits	142	Target Neighborhood Hits	895	Shared Neighborhood Hits	43
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

MYO9B_MOUSE
θ value	0.000461057 (rank : 48)	NC score	0.048245 (rank : 215)
Query Neighborhood Hits	142	Target Neighborhood Hits	311	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

DUET_HUMAN
θ value	0.00102713 (rank : 49)	NC score	0.159881 (rank : 71)
Query Neighborhood Hits	142	Target Neighborhood Hits	1220	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

KPCT_HUMAN
θ value	0.00102713 (rank : 50)	NC score	0.045394 (rank : 219)
Query Neighborhood Hits	142	Target Neighborhood Hits	897	Shared Neighborhood Hits	43
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

UN13B_MOUSE
θ value	0.00134147 (rank : 51)	NC score	0.137134 (rank : 76)
Query Neighborhood Hits	142	Target Neighborhood Hits	210	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

ARHG9_HUMAN
θ value	0.00228821 (rank : 52)	NC score	0.487747 (rank : 33)
Query Neighborhood Hits	142	Target Neighborhood Hits	235	Shared Neighborhood Hits	64
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	0.00228821 (rank : 53)	NC score	0.486739 (rank : 34)
Query Neighborhood Hits	142	Target Neighborhood Hits	234	Shared Neighborhood Hits	64
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

MYO9B_HUMAN
θ value	0.00228821 (rank : 54)	NC score	0.045713 (rank : 217)
Query Neighborhood Hits	142	Target Neighborhood Hits	641	Shared Neighborhood Hits	41
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

ARHG4_MOUSE
θ value	0.00665767 (rank : 55)	NC score	0.484241 (rank : 35)
Query Neighborhood Hits	142	Target Neighborhood Hits	185	Shared Neighborhood Hits	64
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

KPCD_MOUSE
θ value	0.00869519 (rank : 56)	NC score	0.045130 (rank : 220)
Query Neighborhood Hits	142	Target Neighborhood Hits	888	Shared Neighborhood Hits	43
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

TRIO_HUMAN
θ value	0.00869519 (rank : 57)	NC score	0.151711 (rank : 72)
Query Neighborhood Hits	142	Target Neighborhood Hits	1580	Shared Neighborhood Hits	96
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

UN13B_HUMAN
θ value	0.00869519 (rank : 58)	NC score	0.131411 (rank : 77)
Query Neighborhood Hits	142	Target Neighborhood Hits	217	Shared Neighborhood Hits	42
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

MCF2L_MOUSE
θ value	0.0113563 (rank : 59)	NC score	0.400964 (rank : 48)
Query Neighborhood Hits	142	Target Neighborhood Hits	255	Shared Neighborhood Hits	71
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

UN13A_HUMAN
θ value	0.0113563 (rank : 60)	NC score	0.137824 (rank : 75)
Query Neighborhood Hits	142	Target Neighborhood Hits	285	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

DGKQ_HUMAN
θ value	0.0148317 (rank : 61)	NC score	0.099036 (rank : 99)
Query Neighborhood Hits	142	Target Neighborhood Hits	131	Shared Neighborhood Hits	37
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

FGD5_MOUSE
θ value	0.0193708 (rank : 62)	NC score	0.279459 (rank : 64)
Query Neighborhood Hits	142	Target Neighborhood Hits	170	Shared Neighborhood Hits	45
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

VAV3_MOUSE
θ value	0.0193708 (rank : 63)	NC score	0.375434 (rank : 52)
Query Neighborhood Hits	142	Target Neighborhood Hits	404	Shared Neighborhood Hits	80
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

KPCL_MOUSE
θ value	0.0330416 (rank : 64)	NC score	0.041071 (rank : 225)
Query Neighborhood Hits	142	Target Neighborhood Hits	891	Shared Neighborhood Hits	43
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KPCL_HUMAN
θ value	0.0431538 (rank : 65)	NC score	0.041632 (rank : 223)
Query Neighborhood Hits	142	Target Neighborhood Hits	887	Shared Neighborhood Hits	43
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

PKHG1_HUMAN
θ value	0.0563607 (rank : 66)	NC score	0.455496 (rank : 37)
Query Neighborhood Hits	142	Target Neighborhood Hits	174	Shared Neighborhood Hits	60
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

KPCD_HUMAN
θ value	0.0961366 (rank : 67)	NC score	0.042912 (rank : 222)
Query Neighborhood Hits	142	Target Neighborhood Hits	900	Shared Neighborhood Hits	43
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

PCNT_HUMAN
θ value	0.125558 (rank : 68)	NC score	0.054969 (rank : 184)
Query Neighborhood Hits	142	Target Neighborhood Hits	1551	Shared Neighborhood Hits	50
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

STAC_HUMAN
θ value	0.125558 (rank : 69)	NC score	0.147629 (rank : 73)
Query Neighborhood Hits	142	Target Neighborhood Hits	276	Shared Neighborhood Hits	50
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

VAV3_HUMAN
θ value	0.163984 (rank : 70)	NC score	0.370122 (rank : 53)
Query Neighborhood Hits	142	Target Neighborhood Hits	398	Shared Neighborhood Hits	80
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

HMMR_HUMAN
θ value	0.21417 (rank : 71)	NC score	0.043751 (rank : 221)
Query Neighborhood Hits	142	Target Neighborhood Hits	1082	Shared Neighborhood Hits	41
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

CGAT1_HUMAN
θ value	0.279714 (rank : 72)	NC score	0.029304 (rank : 247)
Query Neighborhood Hits	142	Target Neighborhood Hits	69	Shared Neighborhood Hits	7
SwissProt Accessions	Q8TDX6, Q6P9G6, Q8IUF9, Q9NSQ7, Q9NUM9	Gene names	GALNACT1, CHGN
Domain Architecture	No domain graphic available
Description	Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1 (EC 2.4.1.174) (beta4GalNAcT-1).

MRCKG_HUMAN
θ value	0.279714 (rank : 73)	NC score	0.032664 (rank : 242)
Query Neighborhood Hits	142	Target Neighborhood Hits	1519	Shared Neighborhood Hits	64
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

STAC_MOUSE
θ value	0.279714 (rank : 74)	NC score	0.144475 (rank : 74)
Query Neighborhood Hits	142	Target Neighborhood Hits	268	Shared Neighborhood Hits	50
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

HAPIP_HUMAN
θ value	0.365318 (rank : 75)	NC score	0.323705 (rank : 57)
Query Neighborhood Hits	142	Target Neighborhood Hits	350	Shared Neighborhood Hits	67
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

IFT81_MOUSE
θ value	0.47712 (rank : 76)	NC score	0.052021 (rank : 201)
Query Neighborhood Hits	142	Target Neighborhood Hits	959	Shared Neighborhood Hits	37
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

NEMO_HUMAN
θ value	0.47712 (rank : 77)	NC score	0.040170 (rank : 227)
Query Neighborhood Hits	142	Target Neighborhood Hits	820	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y6K9	Gene names	IKBKG, FIP3, NEMO
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (FIP-3).

USE1_HUMAN
θ value	0.47712 (rank : 78)	NC score	0.033371 (rank : 239)
Query Neighborhood Hits	142	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZ43, Q8NCK1, Q9BRT4	Gene names	USE1L
Domain Architecture	No domain graphic available
Description	Vesicle transport protein USE1 (USE1-like protein) (Putative MAPK- activating protein PM26) (Protein p31).

ARHG7_HUMAN
θ value	0.62314 (rank : 79)	NC score	0.312478 (rank : 58)
Query Neighborhood Hits	142	Target Neighborhood Hits	347	Shared Neighborhood Hits	65
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

CGAT1_MOUSE
θ value	0.813845 (rank : 80)	NC score	0.026426 (rank : 251)
Query Neighborhood Hits	142	Target Neighborhood Hits	61	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BJQ9, Q3UZX6, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6	Gene names	Galnact1, Chgn
Domain Architecture	No domain graphic available
Description	Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1 (EC 2.4.1.174) (beta4GalNAcT-1).

DGKG_MOUSE
θ value	0.813845 (rank : 81)	NC score	0.054920 (rank : 185)
Query Neighborhood Hits	142	Target Neighborhood Hits	188	Shared Neighborhood Hits	29
SwissProt Accessions	Q91WG7	Gene names	Dgkg, Dagk3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma) (88 kDa diacylglycerol kinase).

KTN1_MOUSE
θ value	0.813845 (rank : 82)	NC score	0.034500 (rank : 234)
Query Neighborhood Hits	142	Target Neighborhood Hits	1324	Shared Neighborhood Hits	45
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

SLK_MOUSE
θ value	0.813845 (rank : 83)	NC score	0.026893 (rank : 250)
Query Neighborhood Hits	142	Target Neighborhood Hits	1798	Shared Neighborhood Hits	55
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

ARHG7_MOUSE
θ value	1.06291 (rank : 84)	NC score	0.291494 (rank : 60)
Query Neighborhood Hits	142	Target Neighborhood Hits	396	Shared Neighborhood Hits	66
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

SLK_HUMAN
θ value	1.06291 (rank : 85)	NC score	0.024767 (rank : 253)
Query Neighborhood Hits	142	Target Neighborhood Hits	1775	Shared Neighborhood Hits	50
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

CKAP4_HUMAN
θ value	1.38821 (rank : 86)	NC score	0.023700 (rank : 254)
Query Neighborhood Hits	142	Target Neighborhood Hits	592	Shared Neighborhood Hits	27
SwissProt Accessions	Q07065, Q504S5, Q53ES6	Gene names	CKAP4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

KPCE_HUMAN
θ value	1.38821 (rank : 87)	NC score	0.037794 (rank : 230)
Query Neighborhood Hits	142	Target Neighborhood Hits	906	Shared Neighborhood Hits	43
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCE_MOUSE
θ value	1.38821 (rank : 88)	NC score	0.037749 (rank : 231)
Query Neighborhood Hits	142	Target Neighborhood Hits	906	Shared Neighborhood Hits	43
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

TAOK2_HUMAN
θ value	1.38821 (rank : 89)	NC score	0.015308 (rank : 267)
Query Neighborhood Hits	142	Target Neighborhood Hits	1172	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

BPA1_MOUSE
θ value	1.81305 (rank : 90)	NC score	0.026295 (rank : 252)
Query Neighborhood Hits	142	Target Neighborhood Hits	1477	Shared Neighborhood Hits	45
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

CING_HUMAN
θ value	1.81305 (rank : 91)	NC score	0.030025 (rank : 245)
Query Neighborhood Hits	142	Target Neighborhood Hits	1275	Shared Neighborhood Hits	43
SwissProt Accessions	Q9P2M7, Q5T386, Q9NR25	Gene names	CGN, KIAA1319
Domain Architecture
Description	Cingulin.

MLL3_HUMAN
θ value	1.81305 (rank : 92)	NC score	0.020747 (rank : 259)
Query Neighborhood Hits	142	Target Neighborhood Hits	1644	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

MLL3_MOUSE
θ value	1.81305 (rank : 93)	NC score	0.022570 (rank : 255)
Query Neighborhood Hits	142	Target Neighborhood Hits	1399	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

CROCC_MOUSE
θ value	2.36792 (rank : 94)	NC score	0.035938 (rank : 232)
Query Neighborhood Hits	142	Target Neighborhood Hits	1460	Shared Neighborhood Hits	47
SwissProt Accessions	Q8CJ40, Q7TQL2, Q80U01, Q8R0B9	Gene names	Crocc, Kiaa0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

CUTL2_HUMAN
θ value	2.36792 (rank : 95)	NC score	0.021617 (rank : 256)
Query Neighborhood Hits	142	Target Neighborhood Hits	906	Shared Neighborhood Hits	30
SwissProt Accessions	O14529	Gene names	CUTL2, KIAA0293
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

KPCZ_HUMAN
θ value	2.36792 (rank : 96)	NC score	0.035232 (rank : 233)
Query Neighborhood Hits	142	Target Neighborhood Hits	884	Shared Neighborhood Hits	43
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

LIMA1_HUMAN
θ value	2.36792 (rank : 97)	NC score	0.012258 (rank : 269)
Query Neighborhood Hits	142	Target Neighborhood Hits	309	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UHB6, Q2TAN7, Q9BVF2, Q9H8J1, Q9HBN5, Q9NX96, Q9NXC3, Q9NXU6, Q9P0H8, Q9UHB5	Gene names	LIMA1, EPLIN, SREBP3
Domain Architecture
Description	LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm).

PKHG4_HUMAN
θ value	2.36792 (rank : 98)	NC score	0.251252 (rank : 67)
Query Neighborhood Hits	142	Target Neighborhood Hits	200	Shared Neighborhood Hits	49
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

RIMB1_MOUSE
θ value	2.36792 (rank : 99)	NC score	0.051222 (rank : 205)
Query Neighborhood Hits	142	Target Neighborhood Hits	1376	Shared Neighborhood Hits	53
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

BCR_HUMAN
θ value	3.0926 (rank : 100)	NC score	0.224847 (rank : 69)
Query Neighborhood Hits	142	Target Neighborhood Hits	204	Shared Neighborhood Hits	57
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

CB010_HUMAN
θ value	3.0926 (rank : 101)	NC score	0.033982 (rank : 237)
Query Neighborhood Hits	142	Target Neighborhood Hits	130	Shared Neighborhood Hits	9
SwissProt Accessions	Q7Z570, Q6ZN26	Gene names	C2orf10
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf10.

DD19A_HUMAN
θ value	3.0926 (rank : 102)	NC score	0.009423 (rank : 270)
Query Neighborhood Hits	142	Target Neighborhood Hits	107	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NUU7, Q53FM0	Gene names	DDX19A, DDX19L
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DDX19-like protein).

DD19B_HUMAN
θ value	3.0926 (rank : 103)	NC score	0.007680 (rank : 274)
Query Neighborhood Hits	142	Target Neighborhood Hits	109	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UMR2, Q6FIB7, Q6IAE0	Gene names	DDX19B, DBP5, DDX19
Domain Architecture
Description	ATP-dependent RNA helicase DDX19B (EC 3.6.1.-) (DEAD box protein 19B) (DEAD box RNA helicase DEAD5).

KLC4_HUMAN
θ value	3.0926 (rank : 104)	NC score	0.016887 (rank : 265)
Query Neighborhood Hits	142	Target Neighborhood Hits	327	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NSK0	Gene names	KLC4, KNSL8
Domain Architecture
Description	Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8).

PCNT_MOUSE
θ value	3.0926 (rank : 105)	NC score	0.052767 (rank : 196)
Query Neighborhood Hits	142	Target Neighborhood Hits	1207	Shared Neighborhood Hits	46
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

PEPL_MOUSE
θ value	3.0926 (rank : 106)	NC score	0.034165 (rank : 235)
Query Neighborhood Hits	142	Target Neighborhood Hits	1105	Shared Neighborhood Hits	43
SwissProt Accessions	Q9R269, O70231, Q9CUT1, Q9JLZ7	Gene names	Ppl
Domain Architecture
Description	Periplakin.

RIMB1_HUMAN
θ value	3.0926 (rank : 107)	NC score	0.055798 (rank : 180)
Query Neighborhood Hits	142	Target Neighborhood Hits	1479	Shared Neighborhood Hits	55
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

TBCD4_HUMAN
θ value	3.0926 (rank : 108)	NC score	0.016262 (rank : 266)
Query Neighborhood Hits	142	Target Neighborhood Hits	357	Shared Neighborhood Hits	13
SwissProt Accessions	O60343, Q5W0B9	Gene names	TBC1D4, KIAA0603
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160).

ABR_HUMAN
θ value	4.03905 (rank : 109)	NC score	0.219623 (rank : 70)
Query Neighborhood Hits	142	Target Neighborhood Hits	166	Shared Neighborhood Hits	59
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

AKT1_HUMAN
θ value	4.03905 (rank : 110)	NC score	0.019490 (rank : 261)
Query Neighborhood Hits	142	Target Neighborhood Hits	885	Shared Neighborhood Hits	22
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

CHFR_HUMAN
θ value	4.03905 (rank : 111)	NC score	0.019091 (rank : 262)
Query Neighborhood Hits	142	Target Neighborhood Hits	255	Shared Neighborhood Hits	4
SwissProt Accessions	Q96EP1, Q96SL3, Q9NRT4, Q9NT32, Q9NVD5	Gene names	CHFR
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

DGKG_HUMAN
θ value	4.03905 (rank : 112)	NC score	0.059518 (rank : 168)
Query Neighborhood Hits	142	Target Neighborhood Hits	171	Shared Neighborhood Hits	32
SwissProt Accessions	P49619	Gene names	DGKG, DAGK3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma).

FYCO1_MOUSE
θ value	4.03905 (rank : 113)	NC score	0.049678 (rank : 214)
Query Neighborhood Hits	142	Target Neighborhood Hits	1059	Shared Neighborhood Hits	49
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

PDZD8_HUMAN
θ value	4.03905 (rank : 114)	NC score	0.100709 (rank : 97)
Query Neighborhood Hits	142	Target Neighborhood Hits	185	Shared Neighborhood Hits	33
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

CCD50_HUMAN
θ value	5.27518 (rank : 115)	NC score	0.021204 (rank : 258)
Query Neighborhood Hits	142	Target Neighborhood Hits	237	Shared Neighborhood Hits	15
SwissProt Accessions	Q8IVM0, Q86VH7	Gene names	CCDC50, C3orf6
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 50 (Protein Ymer).

CUTL2_MOUSE
θ value	5.27518 (rank : 116)	NC score	0.018902 (rank : 264)
Query Neighborhood Hits	142	Target Neighborhood Hits	771	Shared Neighborhood Hits	25
SwissProt Accessions	P70298	Gene names	Cutl2
Domain Architecture
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

DGKH_HUMAN
θ value	5.27518 (rank : 117)	NC score	0.083949 (rank : 107)
Query Neighborhood Hits	142	Target Neighborhood Hits	255	Shared Neighborhood Hits	44
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

K0100_HUMAN
θ value	5.27518 (rank : 118)	NC score	0.021601 (rank : 257)
Query Neighborhood Hits	142	Target Neighborhood Hits	132	Shared Neighborhood Hits	13
SwissProt Accessions	Q14667, Q3SYN5, Q49A07, Q5H9T4, Q6WG74, Q6ZP51, Q96HH8	Gene names	KIAA0100, BCOX1
Domain Architecture	No domain graphic available
Description	UPF0378 family protein KIAA0100 precursor (Breast cancer overexpressed gene 1 protein) (Antigen MLAA-22).

MACOI_HUMAN
θ value	5.27518 (rank : 119)	NC score	0.030614 (rank : 243)
Query Neighborhood Hits	142	Target Neighborhood Hits	650	Shared Neighborhood Hits	32
SwissProt Accessions	Q8N5G2, Q2TLX5, Q2TLX6, Q9NVG6	Gene names	TMEM57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57).

MACOI_MOUSE
θ value	5.27518 (rank : 120)	NC score	0.029512 (rank : 246)
Query Neighborhood Hits	142	Target Neighborhood Hits	620	Shared Neighborhood Hits	32
SwissProt Accessions	Q7TQE6	Gene names	Tmem57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57) (Brain-specific adaptor protein C61).

MAT1_HUMAN
θ value	5.27518 (rank : 121)	NC score	0.033374 (rank : 238)
Query Neighborhood Hits	142	Target Neighborhood Hits	179	Shared Neighborhood Hits	8
SwissProt Accessions	P51948, Q15817	Gene names	MNAT1, CAP35, MAT1, RNF66
Domain Architecture
Description	CDK-activating kinase assembly factor MAT1 (RING finger protein MAT1) (Menage a trois) (CDK7/cyclin H assembly factor) (p36) (p35) (Cyclin G1-interacting protein) (RING finger protein 66).

MAT1_MOUSE
θ value	5.27518 (rank : 122)	NC score	0.032915 (rank : 241)
Query Neighborhood Hits	142	Target Neighborhood Hits	217	Shared Neighborhood Hits	11
SwissProt Accessions	P51949, Q3TZP0, Q9D8A0, Q9D8D2	Gene names	Mnat1, Mat1
Domain Architecture
Description	CDK-activating kinase assembly factor MAT1 (RING finger protein MAT1) (Menage a trois) (CDK7/cyclin H assembly factor) (p36) (p35).

SDK1_HUMAN
θ value	5.27518 (rank : 123)	NC score	0.002462 (rank : 277)
Query Neighborhood Hits	142	Target Neighborhood Hits	511	Shared Neighborhood Hits	9
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

CHFR_MOUSE
θ value	6.88961 (rank : 124)	NC score	0.015067 (rank : 268)
Query Neighborhood Hits	142	Target Neighborhood Hits	264	Shared Neighborhood Hits	5
SwissProt Accessions	Q810L3, Q8BJZ9, Q8BWH4	Gene names	Chfr
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

CP250_HUMAN
θ value	6.88961 (rank : 125)	NC score	0.045449 (rank : 218)
Query Neighborhood Hits	142	Target Neighborhood Hits	1805	Shared Neighborhood Hits	57
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

CSKI2_MOUSE
θ value	6.88961 (rank : 126)	NC score	0.007854 (rank : 273)
Query Neighborhood Hits	142	Target Neighborhood Hits	812	Shared Neighborhood Hits	16
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

DD19A_MOUSE
θ value	6.88961 (rank : 127)	NC score	0.006617 (rank : 276)
Query Neighborhood Hits	142	Target Neighborhood Hits	105	Shared Neighborhood Hits	4
SwissProt Accessions	Q61655, Q921R0	Gene names	Ddx19a, Ddx19, Eif4a-rs1
Domain Architecture
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DEAD box RNA helicase DEAD5) (mDEAD5) (Eukaryotic translation initiation factor 4A-related sequence 1).

DGKB_HUMAN
θ value	6.88961 (rank : 128)	NC score	0.053823 (rank : 190)
Query Neighborhood Hits	142	Target Neighborhood Hits	238	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Y6T7, O75241, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29	Gene names	DGKB, DAGK2, KIAA0718
Domain Architecture
Description	Diacylglycerol kinase beta (EC 2.7.1.107) (Diglyceride kinase beta) (DGK-beta) (DAG kinase beta) (90 kDa diacylglycerol kinase).

GOGA5_HUMAN
θ value	6.88961 (rank : 129)	NC score	0.030391 (rank : 244)
Query Neighborhood Hits	142	Target Neighborhood Hits	1168	Shared Neighborhood Hits	41
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

IL33_MOUSE
θ value	6.88961 (rank : 130)	NC score	0.028601 (rank : 248)
Query Neighborhood Hits	142	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BVZ5, Q2YEJ4, Q3TQN0, Q99L46	Gene names	Il33
Domain Architecture	No domain graphic available
Description	Interleukin-33 precursor (IL-33).

K0100_MOUSE
θ value	6.88961 (rank : 131)	NC score	0.018918 (rank : 263)
Query Neighborhood Hits	142	Target Neighborhood Hits	111	Shared Neighborhood Hits	12
SwissProt Accessions	Q5SYL3, Q3UE65, Q66JY1, Q6DIC4, Q80U77, Q8C1W6, Q8CE06, Q8CGE3, Q9CSS8	Gene names	Kiaa0100
Domain Architecture	No domain graphic available
Description	UPF0378 family protein KIAA0100 precursor.

KPCG_HUMAN
θ value	6.88961 (rank : 132)	NC score	0.041196 (rank : 224)
Query Neighborhood Hits	142	Target Neighborhood Hits	1126	Shared Neighborhood Hits	50
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCG_MOUSE
θ value	6.88961 (rank : 133)	NC score	0.040689 (rank : 226)
Query Neighborhood Hits	142	Target Neighborhood Hits	1123	Shared Neighborhood Hits	50
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

MYOD1_HUMAN
θ value	6.88961 (rank : 134)	NC score	0.006872 (rank : 275)
Query Neighborhood Hits	142	Target Neighborhood Hits	100	Shared Neighborhood Hits	2
SwissProt Accessions	P15172	Gene names	MYOD1, MYF3, MYOD
Domain Architecture
Description	Myoblast determination protein 1 (Myogenic factor 3) (Myf-3).

NEMO_MOUSE
θ value	6.88961 (rank : 135)	NC score	0.033991 (rank : 236)
Query Neighborhood Hits	142	Target Neighborhood Hits	658	Shared Neighborhood Hits	33
SwissProt Accessions	O88522	Gene names	Ikbkg, Nemo
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3).

RASF5_MOUSE
θ value	6.88961 (rank : 136)	NC score	0.038303 (rank : 229)
Query Neighborhood Hits	142	Target Neighborhood Hits	72	Shared Neighborhood Hits	26
SwissProt Accessions	Q5EBH1, O70407, Q6KAR0, Q8C2E8	Gene names	Rassf5, Nore1, Rapl
Domain Architecture	No domain graphic available
Description	Ras association domain-containing family protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL).

TESK1_HUMAN
θ value	6.88961 (rank : 137)	NC score	0.008477 (rank : 271)
Query Neighborhood Hits	142	Target Neighborhood Hits	864	Shared Neighborhood Hits	22
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TEX9_MOUSE
θ value	6.88961 (rank : 138)	NC score	0.027259 (rank : 249)
Query Neighborhood Hits	142	Target Neighborhood Hits	581	Shared Neighborhood Hits	31
SwissProt Accessions	Q9D845, O54764	Gene names	Tex9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein (Testis-specifically expressed protein 1) (Tsec-1).

CCD93_HUMAN
θ value	8.99809 (rank : 139)	NC score	0.020185 (rank : 260)
Query Neighborhood Hits	142	Target Neighborhood Hits	600	Shared Neighborhood Hits	22
SwissProt Accessions	Q567U6, Q4LE78, Q53TJ2, Q8TBX5, Q9H6R5, Q9NV15	Gene names	CCDC93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

CK5P2_HUMAN
θ value	8.99809 (rank : 140)	NC score	0.039073 (rank : 228)
Query Neighborhood Hits	142	Target Neighborhood Hits	1433	Shared Neighborhood Hits	46
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

KIF3C_MOUSE
θ value	8.99809 (rank : 141)	NC score	0.008470 (rank : 272)
Query Neighborhood Hits	142	Target Neighborhood Hits	468	Shared Neighborhood Hits	29
SwissProt Accessions	O35066, O35229	Gene names	Kif3c
Domain Architecture
Description	Kinesin-like protein KIF3C.

KPCZ_MOUSE
θ value	8.99809 (rank : 142)	NC score	0.033233 (rank : 240)
Query Neighborhood Hits	142	Target Neighborhood Hits	882	Shared Neighborhood Hits	43
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

ABI1_HUMAN
θ value	θ > 10 (rank : 143)	NC score	0.070460 (rank : 132)
Query Neighborhood Hits	142	Target Neighborhood Hits	257	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 144)	NC score	0.075029 (rank : 117)
Query Neighborhood Hits	142	Target Neighborhood Hits	246	Shared Neighborhood Hits	26
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.077477 (rank : 114)
Query Neighborhood Hits	142	Target Neighborhood Hits	350	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 146)	NC score	0.077638 (rank : 112)
Query Neighborhood Hits	142	Target Neighborhood Hits	266	Shared Neighborhood Hits	26
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.067194 (rank : 142)
Query Neighborhood Hits	142	Target Neighborhood Hits	227	Shared Neighborhood Hits	21
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 148)	NC score	0.066232 (rank : 148)
Query Neighborhood Hits	142	Target Neighborhood Hits	227	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AHI1_HUMAN
θ value	θ > 10 (rank : 149)	NC score	0.062155 (rank : 159)
Query Neighborhood Hits	142	Target Neighborhood Hits	537	Shared Neighborhood Hits	31
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 150)	NC score	0.060610 (rank : 164)
Query Neighborhood Hits	142	Target Neighborhood Hits	496	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ANM2_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.051458 (rank : 204)
Query Neighborhood Hits	142	Target Neighborhood Hits	175	Shared Neighborhood Hits	20
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHG6_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.259726 (rank : 66)
Query Neighborhood Hits	142	Target Neighborhood Hits	376	Shared Neighborhood Hits	60
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	θ > 10 (rank : 153)	NC score	0.241037 (rank : 68)
Query Neighborhood Hits	142	Target Neighborhood Hits	394	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHGA_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.355361 (rank : 54)
Query Neighborhood Hits	142	Target Neighborhood Hits	187	Shared Neighborhood Hits	58
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 155)	NC score	0.334748 (rank : 55)
Query Neighborhood Hits	142	Target Neighborhood Hits	125	Shared Neighborhood Hits	56
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

BAIP2_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.053532 (rank : 193)
Query Neighborhood Hits	142	Target Neighborhood Hits	192	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	θ > 10 (rank : 157)	NC score	0.054104 (rank : 189)
Query Neighborhood Hits	142	Target Neighborhood Hits	185	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BCAR1_MOUSE
θ value	θ > 10 (rank : 158)	NC score	0.050929 (rank : 207)
Query Neighborhood Hits	142	Target Neighborhood Hits	438	Shared Neighborhood Hits	27
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BI2L1_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.072628 (rank : 124)
Query Neighborhood Hits	142	Target Neighborhood Hits	156	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 160)	NC score	0.061634 (rank : 161)
Query Neighborhood Hits	142	Target Neighborhood Hits	197	Shared Neighborhood Hits	27
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CASL_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.052066 (rank : 199)
Query Neighborhood Hits	142	Target Neighborhood Hits	259	Shared Neighborhood Hits	25
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CD2AP_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.112282 (rank : 87)
Query Neighborhood Hits	142	Target Neighborhood Hits	315	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 163)	NC score	0.112694 (rank : 86)
Query Neighborhood Hits	142	Target Neighborhood Hits	336	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CHIN_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.059511 (rank : 169)
Query Neighborhood Hits	142	Target Neighborhood Hits	227	Shared Neighborhood Hits	36
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.060244 (rank : 166)
Query Neighborhood Hits	142	Target Neighborhood Hits	229	Shared Neighborhood Hits	36
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.060609 (rank : 165)
Query Neighborhood Hits	142	Target Neighborhood Hits	220	Shared Neighborhood Hits	36
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_MOUSE
θ value	θ > 10 (rank : 167)	NC score	0.062817 (rank : 157)
Query Neighborhood Hits	142	Target Neighborhood Hits	130	Shared Neighborhood Hits	36
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CRKL_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.070652 (rank : 131)
Query Neighborhood Hits	142	Target Neighborhood Hits	313	Shared Neighborhood Hits	23
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 169)	NC score	0.068580 (rank : 137)
Query Neighborhood Hits	142	Target Neighborhood Hits	307	Shared Neighborhood Hits	23
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.063373 (rank : 155)
Query Neighborhood Hits	142	Target Neighborhood Hits	308	Shared Neighborhood Hits	24
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 171)	NC score	0.065371 (rank : 149)
Query Neighborhood Hits	142	Target Neighborhood Hits	314	Shared Neighborhood Hits	25
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CT032_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.050342 (rank : 211)
Query Neighborhood Hits	142	Target Neighborhood Hits	235	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DBNL_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.068800 (rank : 134)
Query Neighborhood Hits	142	Target Neighborhood Hits	244	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 174)	NC score	0.058269 (rank : 174)
Query Neighborhood Hits	142	Target Neighborhood Hits	306	Shared Neighborhood Hits	21
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DGKD_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.071276 (rank : 127)
Query Neighborhood Hits	142	Target Neighborhood Hits	231	Shared Neighborhood Hits	41
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

EEA1_MOUSE
θ value	θ > 10 (rank : 176)	NC score	0.050384 (rank : 210)
Query Neighborhood Hits	142	Target Neighborhood Hits	1637	Shared Neighborhood Hits	58
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

EFS_MOUSE
θ value	θ > 10 (rank : 177)	NC score	0.050893 (rank : 208)
Query Neighborhood Hits	142	Target Neighborhood Hits	389	Shared Neighborhood Hits	23
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

EP15R_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.056305 (rank : 179)
Query Neighborhood Hits	142	Target Neighborhood Hits	1083	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

EP15R_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.060207 (rank : 167)
Query Neighborhood Hits	142	Target Neighborhood Hits	1135	Shared Neighborhood Hits	41
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

EP15_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.052757 (rank : 197)
Query Neighborhood Hits	142	Target Neighborhood Hits	1021	Shared Neighborhood Hits	38
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP15_MOUSE
θ value	θ > 10 (rank : 181)	NC score	0.052689 (rank : 198)
Query Neighborhood Hits	142	Target Neighborhood Hits	820	Shared Neighborhood Hits	36
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

FARP2_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.289350 (rank : 63)
Query Neighborhood Hits	142	Target Neighborhood Hits	240	Shared Neighborhood Hits	55
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FGD5_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.289503 (rank : 62)
Query Neighborhood Hits	142	Target Neighborhood Hits	235	Shared Neighborhood Hits	44
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD6_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.379395 (rank : 51)
Query Neighborhood Hits	142	Target Neighborhood Hits	237	Shared Neighborhood Hits	59
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	θ > 10 (rank : 185)	NC score	0.380091 (rank : 50)
Query Neighborhood Hits	142	Target Neighborhood Hits	282	Shared Neighborhood Hits	59
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

GNRP_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.275466 (rank : 65)
Query Neighborhood Hits	142	Target Neighborhood Hits	239	Shared Neighborhood Hits	51
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 187)	NC score	0.289733 (rank : 61)
Query Neighborhood Hits	142	Target Neighborhood Hits	191	Shared Neighborhood Hits	54
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GRAP2_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.071244 (rank : 128)
Query Neighborhood Hits	142	Target Neighborhood Hits	304	Shared Neighborhood Hits	24
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 189)	NC score	0.070985 (rank : 129)
Query Neighborhood Hits	142	Target Neighborhood Hits	297	Shared Neighborhood Hits	23
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.089017 (rank : 102)
Query Neighborhood Hits	142	Target Neighborhood Hits	307	Shared Neighborhood Hits	26
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.087421 (rank : 103)
Query Neighborhood Hits	142	Target Neighborhood Hits	309	Shared Neighborhood Hits	27
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.080005 (rank : 109)
Query Neighborhood Hits	142	Target Neighborhood Hits	310	Shared Neighborhood Hits	24
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.079955 (rank : 110)
Query Neighborhood Hits	142	Target Neighborhood Hits	312	Shared Neighborhood Hits	24
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRP3_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.082426 (rank : 108)
Query Neighborhood Hits	142	Target Neighborhood Hits	131	Shared Neighborhood Hits	34
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

HCLS1_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.072968 (rank : 123)
Query Neighborhood Hits	142	Target Neighborhood Hits	358	Shared Neighborhood Hits	23
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 196)	NC score	0.075032 (rank : 116)
Query Neighborhood Hits	142	Target Neighborhood Hits	329	Shared Neighborhood Hits	24
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HGS_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.066276 (rank : 146)
Query Neighborhood Hits	142	Target Neighborhood Hits	517	Shared Neighborhood Hits	21
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	θ > 10 (rank : 198)	NC score	0.066273 (rank : 147)
Query Neighborhood Hits	142	Target Neighborhood Hits	589	Shared Neighborhood Hits	21
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

LASP1_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.060617 (rank : 163)
Query Neighborhood Hits	142	Target Neighborhood Hits	293	Shared Neighborhood Hits	23
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.058889 (rank : 171)
Query Neighborhood Hits	142	Target Neighborhood Hits	297	Shared Neighborhood Hits	23
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

NCF1_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.113578 (rank : 85)
Query Neighborhood Hits	142	Target Neighborhood Hits	198	Shared Neighborhood Hits	27
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.110370 (rank : 88)
Query Neighborhood Hits	142	Target Neighborhood Hits	198	Shared Neighborhood Hits	27
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.108057 (rank : 92)
Query Neighborhood Hits	142	Target Neighborhood Hits	229	Shared Neighborhood Hits	25
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.086885 (rank : 105)
Query Neighborhood Hits	142	Target Neighborhood Hits	161	Shared Neighborhood Hits	19
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 205)	NC score	0.085168 (rank : 106)
Query Neighborhood Hits	142	Target Neighborhood Hits	177	Shared Neighborhood Hits	21
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.096817 (rank : 100)
Query Neighborhood Hits	142	Target Neighborhood Hits	312	Shared Neighborhood Hits	28
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.092901 (rank : 101)
Query Neighborhood Hits	142	Target Neighborhood Hits	310	Shared Neighborhood Hits	28
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NEBL_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.058195 (rank : 175)
Query Neighborhood Hits	142	Target Neighborhood Hits	457	Shared Neighborhood Hits	32
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NOXO1_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.062045 (rank : 160)
Query Neighborhood Hits	142	Target Neighborhood Hits	100	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 210)	NC score	0.066914 (rank : 144)
Query Neighborhood Hits	142	Target Neighborhood Hits	114	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.054413 (rank : 186)
Query Neighborhood Hits	142	Target Neighborhood Hits	288	Shared Neighborhood Hits	26
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 212)	NC score	0.059208 (rank : 170)
Query Neighborhood Hits	142	Target Neighborhood Hits	267	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OBSCN_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.055363 (rank : 183)
Query Neighborhood Hits	142	Target Neighborhood Hits	1931	Shared Neighborhood Hits	73
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

OSTF1_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.058595 (rank : 172)
Query Neighborhood Hits	142	Target Neighborhood Hits	466	Shared Neighborhood Hits	24
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 215)	NC score	0.057555 (rank : 176)
Query Neighborhood Hits	142	Target Neighborhood Hits	467	Shared Neighborhood Hits	24
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PACN1_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.050484 (rank : 209)
Query Neighborhood Hits	142	Target Neighborhood Hits	320	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 217)	NC score	0.050236 (rank : 213)
Query Neighborhood Hits	142	Target Neighborhood Hits	283	Shared Neighborhood Hits	27
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.053335 (rank : 194)
Query Neighborhood Hits	142	Target Neighborhood Hits	339	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 219)	NC score	0.053706 (rank : 191)
Query Neighborhood Hits	142	Target Neighborhood Hits	382	Shared Neighborhood Hits	29
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 220)	NC score	0.055638 (rank : 182)
Query Neighborhood Hits	142	Target Neighborhood Hits	385	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 221)	NC score	0.054303 (rank : 187)
Query Neighborhood Hits	142	Target Neighborhood Hits	380	Shared Neighborhood Hits	28
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PEX13_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.050324 (rank : 212)
Query Neighborhood Hits	142	Target Neighborhood Hits	126	Shared Neighborhood Hits	15
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PKHF1_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.107707 (rank : 93)
Query Neighborhood Hits	142	Target Neighborhood Hits	76	Shared Neighborhood Hits	15
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
θ value	θ > 10 (rank : 224)	NC score	0.107042 (rank : 94)
Query Neighborhood Hits	142	Target Neighborhood Hits	80	Shared Neighborhood Hits	14
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF2_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.120346 (rank : 78)
Query Neighborhood Hits	142	Target Neighborhood Hits	75	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.119797 (rank : 79)
Query Neighborhood Hits	142	Target Neighborhood Hits	77	Shared Neighborhood Hits	15
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PLCG1_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.062909 (rank : 156)
Query Neighborhood Hits	142	Target Neighborhood Hits	293	Shared Neighborhood Hits	21
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 228)	NC score	0.065122 (rank : 151)
Query Neighborhood Hits	142	Target Neighborhood Hits	314	Shared Neighborhood Hits	22
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.053018 (rank : 195)
Query Neighborhood Hits	142	Target Neighborhood Hits	280	Shared Neighborhood Hits	18
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP1_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.075149 (rank : 115)
Query Neighborhood Hits	142	Target Neighborhood Hits	389	Shared Neighborhood Hits	35
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 231)	NC score	0.071859 (rank : 126)
Query Neighborhood Hits	142	Target Neighborhood Hits	377	Shared Neighborhood Hits	36
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

RBNS5_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.068645 (rank : 136)
Query Neighborhood Hits	142	Target Neighborhood Hits	242	Shared Neighborhood Hits	24
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	θ > 10 (rank : 233)	NC score	0.064996 (rank : 153)
Query Neighborhood Hits	142	Target Neighborhood Hits	266	Shared Neighborhood Hits	24
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

REPS1_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.057475 (rank : 177)
Query Neighborhood Hits	142	Target Neighborhood Hits	205	Shared Neighborhood Hits	10
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS1_MOUSE
θ value	θ > 10 (rank : 235)	NC score	0.058393 (rank : 173)
Query Neighborhood Hits	142	Target Neighborhood Hits	204	Shared Neighborhood Hits	10
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS2_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.067223 (rank : 141)
Query Neighborhood Hits	142	Target Neighborhood Hits	131	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_MOUSE
θ value	θ > 10 (rank : 237)	NC score	0.067256 (rank : 140)
Query Neighborhood Hits	142	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

RHG04_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.057001 (rank : 178)
Query Neighborhood Hits	142	Target Neighborhood Hits	307	Shared Neighborhood Hits	27
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RIMB2_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.055647 (rank : 181)
Query Neighborhood Hits	142	Target Neighborhood Hits	263	Shared Neighborhood Hits	23
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 240)	NC score	0.054302 (rank : 188)
Query Neighborhood Hits	142	Target Neighborhood Hits	246	Shared Neighborhood Hits	20
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RUFY1_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.051100 (rank : 206)
Query Neighborhood Hits	142	Target Neighborhood Hits	848	Shared Neighborhood Hits	42
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

RUFY1_MOUSE
θ value	θ > 10 (rank : 242)	NC score	0.052057 (rank : 200)
Query Neighborhood Hits	142	Target Neighborhood Hits	765	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY2_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.053604 (rank : 192)
Query Neighborhood Hits	142	Target Neighborhood Hits	1208	Shared Neighborhood Hits	50
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

RUFY2_MOUSE
θ value	θ > 10 (rank : 244)	NC score	0.051557 (rank : 203)
Query Neighborhood Hits	142	Target Neighborhood Hits	820	Shared Neighborhood Hits	40
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

SH3G1_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.068694 (rank : 135)
Query Neighborhood Hits	142	Target Neighborhood Hits	307	Shared Neighborhood Hits	29
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.066858 (rank : 145)
Query Neighborhood Hits	142	Target Neighborhood Hits	291	Shared Neighborhood Hits	27
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.065291 (rank : 150)
Query Neighborhood Hits	142	Target Neighborhood Hits	324	Shared Neighborhood Hits	26
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.065061 (rank : 152)
Query Neighborhood Hits	142	Target Neighborhood Hits	319	Shared Neighborhood Hits	26
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.068394 (rank : 139)
Query Neighborhood Hits	142	Target Neighborhood Hits	222	Shared Neighborhood Hits	23
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 250)	NC score	0.070737 (rank : 130)
Query Neighborhood Hits	142	Target Neighborhood Hits	236	Shared Neighborhood Hits	24
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.118987 (rank : 80)
Query Neighborhood Hits	142	Target Neighborhood Hits	341	Shared Neighborhood Hits	32
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.109358 (rank : 89)
Query Neighborhood Hits	142	Target Neighborhood Hits	332	Shared Neighborhood Hits	33
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SHAN1_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.062319 (rank : 158)
Query Neighborhood Hits	142	Target Neighborhood Hits	1041	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHAN2_MOUSE
θ value	θ > 10 (rank : 254)	NC score	0.087039 (rank : 104)
Query Neighborhood Hits	142	Target Neighborhood Hits	446	Shared Neighborhood Hits	30
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SOS1_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.117691 (rank : 81)
Query Neighborhood Hits	142	Target Neighborhood Hits	274	Shared Neighborhood Hits	33
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	θ > 10 (rank : 256)	NC score	0.108482 (rank : 91)
Query Neighborhood Hits	142	Target Neighborhood Hits	281	Shared Neighborhood Hits	35
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS2_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.114159 (rank : 84)
Query Neighborhood Hits	142	Target Neighborhood Hits	193	Shared Neighborhood Hits	34
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SRBS1_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.103618 (rank : 95)
Query Neighborhood Hits	142	Target Neighborhood Hits	396	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 259)	NC score	0.108711 (rank : 90)
Query Neighborhood Hits	142	Target Neighborhood Hits	409	Shared Neighborhood Hits	27
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.073871 (rank : 119)
Query Neighborhood Hits	142	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 261)	NC score	0.072404 (rank : 125)
Query Neighborhood Hits	142	Target Neighborhood Hits	292	Shared Neighborhood Hits	25
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

STAC3_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.117493 (rank : 82)
Query Neighborhood Hits	142	Target Neighborhood Hits	228	Shared Neighborhood Hits	47
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 263)	NC score	0.117207 (rank : 83)
Query Neighborhood Hits	142	Target Neighborhood Hits	232	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAM1_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.077765 (rank : 111)
Query Neighborhood Hits	142	Target Neighborhood Hits	271	Shared Neighborhood Hits	25
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.077607 (rank : 113)
Query Neighborhood Hits	142	Target Neighborhood Hits	273	Shared Neighborhood Hits	24
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.073291 (rank : 121)
Query Neighborhood Hits	142	Target Neighborhood Hits	288	Shared Neighborhood Hits	28
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.073440 (rank : 120)
Query Neighborhood Hits	142	Target Neighborhood Hits	285	Shared Neighborhood Hits	26
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

TCGAP_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.051760 (rank : 202)
Query Neighborhood Hits	142	Target Neighborhood Hits	872	Shared Neighborhood Hits	34
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.060954 (rank : 162)
Query Neighborhood Hits	142	Target Neighborhood Hits	409	Shared Neighborhood Hits	35
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

VINEX_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.101319 (rank : 96)
Query Neighborhood Hits	142	Target Neighborhood Hits	270	Shared Neighborhood Hits	27
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.099501 (rank : 98)
Query Neighborhood Hits	142	Target Neighborhood Hits	286	Shared Neighborhood Hits	27
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ZFY16_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.068471 (rank : 138)
Query Neighborhood Hits	142	Target Neighborhood Hits	125	Shared Neighborhood Hits	12
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY16_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.069375 (rank : 133)
Query Neighborhood Hits	142	Target Neighborhood Hits	108	Shared Neighborhood Hits	10
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY21_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.064318 (rank : 154)
Query Neighborhood Hits	142	Target Neighborhood Hits	72	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.067160 (rank : 143)
Query Neighborhood Hits	142	Target Neighborhood Hits	72	Shared Neighborhood Hits	10
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY28_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.074434 (rank : 118)
Query Neighborhood Hits	142	Target Neighborhood Hits	152	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV9_HUMAN
θ value	θ > 10 (rank : 277)	NC score	0.073184 (rank : 122)
Query Neighborhood Hits	142	Target Neighborhood Hits	134	Shared Neighborhood Hits	10
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

Hits sorted by NC score

ARHG2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	142	Target Neighborhood Hits	142	Shared Neighborhood Hits	142
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
NC score	0.981347 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	142	Target Neighborhood Hits	120	Shared Neighborhood Hits	97
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

LBC_HUMAN
NC score	0.942818 (rank : 3)	θ value	2.29227e-112 (rank : 4)
Query Neighborhood Hits	142	Target Neighborhood Hits	90	Shared Neighborhood Hits	56
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHG1_HUMAN
NC score	0.819421 (rank : 4)	θ value	2.67802e-36 (rank : 8)
Query Neighborhood Hits	142	Target Neighborhood Hits	176	Shared Neighborhood Hits	59
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

RGNEF_MOUSE
NC score	0.803504 (rank : 5)	θ value	1.86652e-130 (rank : 3)
Query Neighborhood Hits	142	Target Neighborhood Hits	641	Shared Neighborhood Hits	96
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ARHG1_MOUSE
NC score	0.800198 (rank : 6)	θ value	6.59618e-35 (rank : 9)
Query Neighborhood Hits	142	Target Neighborhood Hits	266	Shared Neighborhood Hits	54
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHGC_MOUSE
NC score	0.758780 (rank : 7)	θ value	3.05695e-40 (rank : 7)
Query Neighborhood Hits	142	Target Neighborhood Hits	344	Shared Neighborhood Hits	63
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_HUMAN
NC score	0.758059 (rank : 8)	θ value	3.05695e-40 (rank : 6)
Query Neighborhood Hits	142	Target Neighborhood Hits	351	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGB_HUMAN
NC score	0.754746 (rank : 9)	θ value	4.71619e-41 (rank : 5)
Query Neighborhood Hits	142	Target Neighborhood Hits	375	Shared Neighborhood Hits	62
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHG3_HUMAN
NC score	0.659849 (rank : 10)	θ value	1.02475e-11 (rank : 17)
Query Neighborhood Hits	142	Target Neighborhood Hits	82	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.659220 (rank : 11)	θ value	2.28291e-11 (rank : 20)
Query Neighborhood Hits	142	Target Neighborhood Hits	85	Shared Neighborhood Hits	60
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHGG_HUMAN
NC score	0.638909 (rank : 12)	θ value	1.133e-10 (rank : 21)
Query Neighborhood Hits	142	Target Neighborhood Hits	129	Shared Neighborhood Hits	62
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG8_HUMAN
NC score	0.633709 (rank : 13)	θ value	3.29651e-10 (rank : 23)
Query Neighborhood Hits	142	Target Neighborhood Hits	85	Shared Neighborhood Hits	61
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
NC score	0.628003 (rank : 14)	θ value	1.74796e-11 (rank : 18)
Query Neighborhood Hits	142	Target Neighborhood Hits	79	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGG_MOUSE
NC score	0.615913 (rank : 15)	θ value	1.17247e-07 (rank : 34)
Query Neighborhood Hits	142	Target Neighborhood Hits	152	Shared Neighborhood Hits	61
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG5_HUMAN
NC score	0.606247 (rank : 16)	θ value	2.36244e-08 (rank : 29)
Query Neighborhood Hits	142	Target Neighborhood Hits	172	Shared Neighborhood Hits	63
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

NGEF_HUMAN
NC score	0.581964 (rank : 17)	θ value	6.87365e-08 (rank : 32)
Query Neighborhood Hits	142	Target Neighborhood Hits	166	Shared Neighborhood Hits	61
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ECT2_MOUSE
NC score	0.576935 (rank : 18)	θ value	2.61198e-07 (rank : 36)
Query Neighborhood Hits	142	Target Neighborhood Hits	98	Shared Neighborhood Hits	63
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

NGEF_MOUSE
NC score	0.574491 (rank : 19)	θ value	8.97725e-08 (rank : 33)
Query Neighborhood Hits	142	Target Neighborhood Hits	228	Shared Neighborhood Hits	61
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHGF_HUMAN
NC score	0.574332 (rank : 20)	θ value	5.26297e-08 (rank : 31)
Query Neighborhood Hits	142	Target Neighborhood Hits	214	Shared Neighborhood Hits	58
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ECT2_HUMAN
NC score	0.563841 (rank : 21)	θ value	4.45536e-07 (rank : 37)
Query Neighborhood Hits	142	Target Neighborhood Hits	98	Shared Neighborhood Hits	62
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

FGD3_MOUSE
NC score	0.561352 (rank : 22)	θ value	2.20605e-14 (rank : 13)
Query Neighborhood Hits	142	Target Neighborhood Hits	257	Shared Neighborhood Hits	65
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

PREX1_HUMAN
NC score	0.534354 (rank : 23)	θ value	9.59137e-10 (rank : 25)
Query Neighborhood Hits	142	Target Neighborhood Hits	177	Shared Neighborhood Hits	62
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

FGD3_HUMAN
NC score	0.530790 (rank : 24)	θ value	9.26847e-13 (rank : 15)
Query Neighborhood Hits	142	Target Neighborhood Hits	249	Shared Neighborhood Hits	63
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD2_MOUSE
NC score	0.524435 (rank : 25)	θ value	4.76016e-09 (rank : 27)
Query Neighborhood Hits	142	Target Neighborhood Hits	163	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD4_HUMAN
NC score	0.521134 (rank : 26)	θ value	1.74796e-11 (rank : 19)
Query Neighborhood Hits	142	Target Neighborhood Hits	219	Shared Neighborhood Hits	63
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
NC score	0.519678 (rank : 27)	θ value	6.00763e-12 (rank : 16)
Query Neighborhood Hits	142	Target Neighborhood Hits	227	Shared Neighborhood Hits	63
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD2_HUMAN
NC score	0.514917 (rank : 28)	θ value	4.0297e-08 (rank : 30)
Query Neighborhood Hits	142	Target Neighborhood Hits	151	Shared Neighborhood Hits	64
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

TIAM1_MOUSE
NC score	0.514879 (rank : 29)	θ value	1.29631e-06 (rank : 39)
Query Neighborhood Hits	142	Target Neighborhood Hits	205	Shared Neighborhood Hits	61
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

FGD1_MOUSE
NC score	0.512611 (rank : 30)	θ value	2.52405e-10 (rank : 22)
Query Neighborhood Hits	142	Target Neighborhood Hits	387	Shared Neighborhood Hits	68
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_HUMAN
NC score	0.507441 (rank : 31)	θ value	1.63604e-09 (rank : 26)
Query Neighborhood Hits	142	Target Neighborhood Hits	367	Shared Neighborhood Hits	68
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

TIAM1_HUMAN
NC score	0.503914 (rank : 32)	θ value	3.77169e-06 (rank : 41)
Query Neighborhood Hits	142	Target Neighborhood Hits	225	Shared Neighborhood Hits	62
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG9_HUMAN
NC score	0.487747 (rank : 33)	θ value	0.00228821 (rank : 52)
Query Neighborhood Hits	142	Target Neighborhood Hits	235	Shared Neighborhood Hits	64
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.486739 (rank : 34)	θ value	0.00228821 (rank : 53)
Query Neighborhood Hits	142	Target Neighborhood Hits	234	Shared Neighborhood Hits	64
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG4_MOUSE
NC score	0.484241 (rank : 35)	θ value	0.00665767 (rank : 55)
Query Neighborhood Hits	142	Target Neighborhood Hits	185	Shared Neighborhood Hits	64
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_HUMAN
NC score	0.469091 (rank : 36)	θ value	0.000158464 (rank : 46)
Query Neighborhood Hits	142	Target Neighborhood Hits	242	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PKHG1_HUMAN
NC score	0.455496 (rank : 37)	θ value	0.0563607 (rank : 66)
Query Neighborhood Hits	142	Target Neighborhood Hits	174	Shared Neighborhood Hits	60
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ITSN2_HUMAN
NC score	0.444746 (rank : 38)	θ value	6.20254e-17 (rank : 10)
Query Neighborhood Hits	142	Target Neighborhood Hits	1173	Shared Neighborhood Hits	93
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

MCF2_HUMAN
NC score	0.438015 (rank : 39)	θ value	0.000121331 (rank : 45)
Query Neighborhood Hits	142	Target Neighborhood Hits	166	Shared Neighborhood Hits	66
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

VAV2_HUMAN
NC score	0.428220 (rank : 40)	θ value	1.38499e-08 (rank : 28)
Query Neighborhood Hits	142	Target Neighborhood Hits	453	Shared Neighborhood Hits	86
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
NC score	0.422787 (rank : 41)	θ value	1.53129e-07 (rank : 35)
Query Neighborhood Hits	142	Target Neighborhood Hits	456	Shared Neighborhood Hits	83
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ITSN2_MOUSE
NC score	0.421538 (rank : 42)	θ value	5.8054e-15 (rank : 12)
Query Neighborhood Hits	142	Target Neighborhood Hits	1371	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

VAV_MOUSE
NC score	0.418520 (rank : 43)	θ value	1.69304e-06 (rank : 40)
Query Neighborhood Hits	142	Target Neighborhood Hits	430	Shared Neighborhood Hits	86
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

DNMBP_MOUSE
NC score	0.412549 (rank : 44)	θ value	8.40245e-06 (rank : 42)
Query Neighborhood Hits	142	Target Neighborhood Hits	435	Shared Neighborhood Hits	70
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ITSN1_HUMAN
NC score	0.408380 (rank : 45)	θ value	2.60593e-15 (rank : 11)
Query Neighborhood Hits	142	Target Neighborhood Hits	1757	Shared Neighborhood Hits	103
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.405795 (rank : 46)	θ value	4.91457e-14 (rank : 14)
Query Neighborhood Hits	142	Target Neighborhood Hits	1669	Shared Neighborhood Hits	104
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

DNMBP_HUMAN
NC score	0.403207 (rank : 47)	θ value	1.87187e-05 (rank : 43)
Query Neighborhood Hits	142	Target Neighborhood Hits	413	Shared Neighborhood Hits	72
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

MCF2L_MOUSE
NC score	0.400964 (rank : 48)	θ value	0.0113563 (rank : 59)
Query Neighborhood Hits	142	Target Neighborhood Hits	255	Shared Neighborhood Hits	71
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

VAV_HUMAN
NC score	0.400352 (rank : 49)	θ value	4.1701e-05 (rank : 44)
Query Neighborhood Hits	142	Target Neighborhood Hits	452	Shared Neighborhood Hits	86
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

FGD6_MOUSE
NC score	0.380091 (rank : 50)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	142	Target Neighborhood Hits	282	Shared Neighborhood Hits	59
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD6_HUMAN
NC score	0.379395 (rank : 51)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	142	Target Neighborhood Hits	237	Shared Neighborhood Hits	59
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

VAV3_MOUSE
NC score	0.375434 (rank : 52)	θ value	0.0193708 (rank : 63)
Query Neighborhood Hits	142	Target Neighborhood Hits	404	Shared Neighborhood Hits	80
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV3_HUMAN
NC score	0.370122 (rank : 53)	θ value	0.163984 (rank : 70)
Query Neighborhood Hits	142	Target Neighborhood Hits	398	Shared Neighborhood Hits	80
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ARHGA_HUMAN
NC score	0.355361 (rank : 54)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	142	Target Neighborhood Hits	187	Shared Neighborhood Hits	58
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
NC score	0.334748 (rank : 55)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	142	Target Neighborhood Hits	125	Shared Neighborhood Hits	56
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

FARP2_MOUSE
NC score	0.332994 (rank : 56)	θ value	9.59137e-10 (rank : 24)
Query Neighborhood Hits	142	Target Neighborhood Hits	209	Shared Neighborhood Hits	59
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

HAPIP_HUMAN
NC score	0.323705 (rank : 57)	θ value	0.365318 (rank : 75)
Query Neighborhood Hits	142	Target Neighborhood Hits	350	Shared Neighborhood Hits	67
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ARHG7_HUMAN
NC score	0.312478 (rank : 58)	θ value	0.62314 (rank : 79)
Query Neighborhood Hits	142	Target Neighborhood Hits	347	Shared Neighborhood Hits	65
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

FARP1_HUMAN
NC score	0.304874 (rank : 59)	θ value	4.45536e-07 (rank : 38)
Query Neighborhood Hits	142	Target Neighborhood Hits	241	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

ARHG7_MOUSE
NC score	0.291494 (rank : 60)	θ value	1.06291 (rank : 84)
Query Neighborhood Hits	142	Target Neighborhood Hits	396	Shared Neighborhood Hits	66
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

GNRP_MOUSE
NC score	0.289733 (rank : 61)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	142	Target Neighborhood Hits	191	Shared Neighborhood Hits	54
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

FGD5_HUMAN
NC score	0.289503 (rank : 62)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	142	Target Neighborhood Hits	235	Shared Neighborhood Hits	44
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FARP2_HUMAN
NC score	0.289350 (rank : 63)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	142	Target Neighborhood Hits	240	Shared Neighborhood Hits	55
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FGD5_MOUSE
NC score	0.279459 (rank : 64)	θ value	0.0193708 (rank : 62)
Query Neighborhood Hits	142	Target Neighborhood Hits	170	Shared Neighborhood Hits	45
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

GNRP_HUMAN
NC score	0.275466 (rank : 65)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	142	Target Neighborhood Hits	239	Shared Neighborhood Hits	51
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

ARHG6_HUMAN
NC score	0.259726 (rank : 66)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	142	Target Neighborhood Hits	376	Shared Neighborhood Hits	60
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

PKHG4_HUMAN
NC score	0.251252 (rank : 67)	θ value	2.36792 (rank : 98)
Query Neighborhood Hits	142	Target Neighborhood Hits	200	Shared Neighborhood Hits	49
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

ARHG6_MOUSE
NC score	0.241037 (rank : 68)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	142	Target Neighborhood Hits	394	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

BCR_HUMAN
NC score	0.224847 (rank : 69)	θ value	3.0926 (rank : 100)
Query Neighborhood Hits	142	Target Neighborhood Hits	204	Shared Neighborhood Hits	57
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ABR_HUMAN
NC score	0.219623 (rank : 70)	θ value	4.03905 (rank : 109)
Query Neighborhood Hits	142	Target Neighborhood Hits	166	Shared Neighborhood Hits	59
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

DUET_HUMAN
NC score	0.159881 (rank : 71)	θ value	0.00102713 (rank : 49)
Query Neighborhood Hits	142	Target Neighborhood Hits	1220	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

TRIO_HUMAN
NC score	0.151711 (rank : 72)	θ value	0.00869519 (rank : 57)
Query Neighborhood Hits	142	Target Neighborhood Hits	1580	Shared Neighborhood Hits	96
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

STAC_HUMAN
NC score	0.147629 (rank : 73)	θ value	0.125558 (rank : 69)
Query Neighborhood Hits	142	Target Neighborhood Hits	276	Shared Neighborhood Hits	50
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
NC score	0.144475 (rank : 74)	θ value	0.279714 (rank : 74)
Query Neighborhood Hits	142	Target Neighborhood Hits	268	Shared Neighborhood Hits	50
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

UN13A_HUMAN
NC score	0.137824 (rank : 75)	θ value	0.0113563 (rank : 60)
Query Neighborhood Hits	142	Target Neighborhood Hits	285	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_MOUSE
NC score	0.137134 (rank : 76)	θ value	0.00134147 (rank : 51)
Query Neighborhood Hits	142	Target Neighborhood Hits	210	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_HUMAN
NC score	0.131411 (rank : 77)	θ value	0.00869519 (rank : 58)
Query Neighborhood Hits	142	Target Neighborhood Hits	217	Shared Neighborhood Hits	42
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

PKHF2_HUMAN
NC score	0.120346 (rank : 78)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	142	Target Neighborhood Hits	75	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
NC score	0.119797 (rank : 79)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	142	Target Neighborhood Hits	77	Shared Neighborhood Hits	15
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

SH3K1_HUMAN
NC score	0.118987 (rank : 80)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	142	Target Neighborhood Hits	341	Shared Neighborhood Hits	32
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SOS1_HUMAN
NC score	0.117691 (rank : 81)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	142	Target Neighborhood Hits	274	Shared Neighborhood Hits	33
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

STAC3_HUMAN
NC score	0.117493 (rank : 82)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	142	Target Neighborhood Hits	228	Shared Neighborhood Hits	47
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
NC score	0.117207 (rank : 83)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	142	Target Neighborhood Hits	232	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

SOS2_HUMAN
NC score	0.114159 (rank : 84)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	142	Target Neighborhood Hits	193	Shared Neighborhood Hits	34
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

NCF1_HUMAN
NC score	0.113578 (rank : 85)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	142	Target Neighborhood Hits	198	Shared Neighborhood Hits	27
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

CD2AP_MOUSE
NC score	0.112694 (rank : 86)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	142	Target Neighborhood Hits	336	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CD2AP_HUMAN
NC score	0.112282 (rank : 87)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	142	Target Neighborhood Hits	315	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

NCF1_MOUSE
NC score	0.110370 (rank : 88)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	142	Target Neighborhood Hits	198	Shared Neighborhood Hits	27
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

SH3K1_MOUSE
NC score	0.109358 (rank : 89)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	142	Target Neighborhood Hits	332	Shared Neighborhood Hits	33
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SRBS1_MOUSE
NC score	0.108711 (rank : 90)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	142	Target Neighborhood Hits	409	Shared Neighborhood Hits	27
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SOS1_MOUSE
NC score	0.108482 (rank : 91)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	142	Target Neighborhood Hits	281	Shared Neighborhood Hits	35
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

NCF2_HUMAN
NC score	0.108057 (rank : 92)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	142	Target Neighborhood Hits	229	Shared Neighborhood Hits	25
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

PKHF1_HUMAN
NC score	0.107707 (rank : 93)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	142	Target Neighborhood Hits	76	Shared Neighborhood Hits	15
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
NC score	0.107042 (rank : 94)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	142	Target Neighborhood Hits	80	Shared Neighborhood Hits	14
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

SRBS1_HUMAN
NC score	0.103618 (rank : 95)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	142	Target Neighborhood Hits	396	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

VINEX_HUMAN
NC score	0.101319 (rank : 96)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	142	Target Neighborhood Hits	270	Shared Neighborhood Hits	27
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

PDZD8_HUMAN
NC score	0.100709 (rank : 97)	θ value	4.03905 (rank : 114)
Query Neighborhood Hits	142	Target Neighborhood Hits	185	Shared Neighborhood Hits	33
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

VINEX_MOUSE
NC score	0.099501 (rank : 98)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	142	Target Neighborhood Hits	286	Shared Neighborhood Hits	27
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

DGKQ_HUMAN
NC score	0.099036 (rank : 99)	θ value	0.0148317 (rank : 61)
Query Neighborhood Hits	142	Target Neighborhood Hits	131	Shared Neighborhood Hits	37
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

NCK1_HUMAN
NC score	0.096817 (rank : 100)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	142	Target Neighborhood Hits	312	Shared Neighborhood Hits	28
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
NC score	0.092901 (rank : 101)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	142	Target Neighborhood Hits	310	Shared Neighborhood Hits	28
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

GRAP_HUMAN
NC score	0.089017 (rank : 102)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	142	Target Neighborhood Hits	307	Shared Neighborhood Hits	26
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
NC score	0.087421 (rank : 103)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	142	Target Neighborhood Hits	309	Shared Neighborhood Hits	27
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

SHAN2_MOUSE
NC score	0.087039 (rank : 104)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	142	Target Neighborhood Hits	446	Shared Neighborhood Hits	30
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

NCF4_HUMAN
NC score	0.086885 (rank : 105)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	142	Target Neighborhood Hits	161	Shared Neighborhood Hits	19
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
NC score	0.085168 (rank : 106)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	142	Target Neighborhood Hits	177	Shared Neighborhood Hits	21
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

DGKH_HUMAN
NC score	0.083949 (rank : 107)	θ value	5.27518 (rank : 117)
Query Neighborhood Hits	142	Target Neighborhood Hits	255	Shared Neighborhood Hits	44
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

GRP3_HUMAN
NC score	0.082426 (rank : 108)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	142	Target Neighborhood Hits	131	Shared Neighborhood Hits	34
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

GRB2_HUMAN
NC score	0.080005 (rank : 109)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	142	Target Neighborhood Hits	310	Shared Neighborhood Hits	24
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.079955 (rank : 110)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	142	Target Neighborhood Hits	312	Shared Neighborhood Hits	24
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

STAM1_HUMAN
NC score	0.077765 (rank : 111)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	142	Target Neighborhood Hits	271	Shared Neighborhood Hits	25
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ABI2_MOUSE
NC score	0.077638 (rank : 112)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	142	Target Neighborhood Hits	266	Shared Neighborhood Hits	26
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

STAM1_MOUSE
NC score	0.077607 (rank : 113)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	142	Target Neighborhood Hits	273	Shared Neighborhood Hits	24
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ABI2_HUMAN
NC score	0.077477 (rank : 114)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	142	Target Neighborhood Hits	350	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

PPIP1_HUMAN
NC score	0.075149 (rank : 115)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	142	Target Neighborhood Hits	389	Shared Neighborhood Hits	35
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

HCLS1_MOUSE
NC score	0.075032 (rank : 116)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	142	Target Neighborhood Hits	329	Shared Neighborhood Hits	24
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

ABI1_MOUSE
NC score	0.075029 (rank : 117)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	142	Target Neighborhood Hits	246	Shared Neighborhood Hits	26
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ZFY28_HUMAN
NC score	0.074434 (rank : 118)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	142	Target Neighborhood Hits	152	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

SRC8_HUMAN
NC score	0.073871 (rank : 119)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	142	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

STAM2_MOUSE
NC score	0.073440 (rank : 120)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	142	Target Neighborhood Hits	285	Shared Neighborhood Hits	26
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STAM2_HUMAN
NC score	0.073291 (rank : 121)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	142	Target Neighborhood Hits	288	Shared Neighborhood Hits	28
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

ZFYV9_HUMAN
NC score	0.073184 (rank : 122)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	142	Target Neighborhood Hits	134	Shared Neighborhood Hits	10
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

HCLS1_HUMAN
NC score	0.072968 (rank : 123)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	142	Target Neighborhood Hits	358	Shared Neighborhood Hits	23
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

BI2L1_HUMAN
NC score	0.072628 (rank : 124)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	142	Target Neighborhood Hits	156	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

SRC8_MOUSE
NC score	0.072404 (rank : 125)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	142	Target Neighborhood Hits	292	Shared Neighborhood Hits	25
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

PPIP1_MOUSE
NC score	0.071859 (rank : 126)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	142	Target Neighborhood Hits	377	Shared Neighborhood Hits	36
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

DGKD_HUMAN
NC score	0.071276 (rank : 127)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	142	Target Neighborhood Hits	231	Shared Neighborhood Hits	41
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

GRAP2_HUMAN
NC score	0.071244 (rank : 128)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	142	Target Neighborhood Hits	304	Shared Neighborhood Hits	24
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
NC score	0.070985 (rank : 129)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	142	Target Neighborhood Hits	297	Shared Neighborhood Hits	23
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

SH3G3_MOUSE
NC score	0.070737 (rank : 130)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	142	Target Neighborhood Hits	236	Shared Neighborhood Hits	24
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

CRKL_HUMAN
NC score	0.070652 (rank : 131)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	142	Target Neighborhood Hits	313	Shared Neighborhood Hits	23
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

ABI1_HUMAN
NC score	0.070460 (rank : 132)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	142	Target Neighborhood Hits	257	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ZFY16_MOUSE
NC score	0.069375 (rank : 133)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	142	Target Neighborhood Hits	108	Shared Neighborhood Hits	10
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

DBNL_HUMAN
NC score	0.068800 (rank : 134)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	142	Target Neighborhood Hits	244	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

SH3G1_HUMAN
NC score	0.068694 (rank : 135)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	142	Target Neighborhood Hits	307	Shared Neighborhood Hits	29
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

RBNS5_HUMAN
NC score	0.068645 (rank : 136)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	142	Target Neighborhood Hits	242	Shared Neighborhood Hits	24
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

CRKL_MOUSE
NC score	0.068580 (rank : 137)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	142	Target Neighborhood Hits	307	Shared Neighborhood Hits	23
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

ZFY16_HUMAN
NC score	0.068471 (rank : 138)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	142	Target Neighborhood Hits	125	Shared Neighborhood Hits	12
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

SH3G3_HUMAN
NC score	0.068394 (rank : 139)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	142	Target Neighborhood Hits	222	Shared Neighborhood Hits	23
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

REPS2_MOUSE
NC score	0.067256 (rank : 140)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	142	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_HUMAN
NC score	0.067223 (rank : 141)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	142	Target Neighborhood Hits	131	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

ABI3_HUMAN
NC score	0.067194 (rank : 142)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	142	Target Neighborhood Hits	227	Shared Neighborhood Hits	21
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ZFY21_MOUSE
NC score	0.067160 (rank : 143)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	142	Target Neighborhood Hits	72	Shared Neighborhood Hits	10
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

NOXO1_MOUSE
NC score	0.066914 (rank : 144)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	142	Target Neighborhood Hits	114	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

SH3G1_MOUSE
NC score	0.066858 (rank : 145)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	142	Target Neighborhood Hits	291	Shared Neighborhood Hits	27
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

HGS_HUMAN
NC score	0.066276 (rank : 146)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	142	Target Neighborhood Hits	517	Shared Neighborhood Hits	21
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
NC score	0.066273 (rank : 147)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	142	Target Neighborhood Hits	589	Shared Neighborhood Hits	21
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

ABI3_MOUSE
NC score	0.066232 (rank : 148)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	142	Target Neighborhood Hits	227	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

CRK_MOUSE
NC score	0.065371 (rank : 149)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	142	Target Neighborhood Hits	314	Shared Neighborhood Hits	25
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SH3G2_HUMAN
NC score	0.065291 (rank : 150)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	142	Target Neighborhood Hits	324	Shared Neighborhood Hits	26
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

PLCG1_MOUSE
NC score	0.065122 (rank : 151)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	142	Target Neighborhood Hits	314	Shared Neighborhood Hits	22
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SH3G2_MOUSE
NC score	0.065061 (rank : 152)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	142	Target Neighborhood Hits	319	Shared Neighborhood Hits	26
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

RBNS5_MOUSE
NC score	0.064996 (rank : 153)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	142	Target Neighborhood Hits	266	Shared Neighborhood Hits	24
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

ZFY21_HUMAN
NC score	0.064318 (rank : 154)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	142	Target Neighborhood Hits	72	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

CRK_HUMAN
NC score	0.063373 (rank : 155)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	142	Target Neighborhood Hits	308	Shared Neighborhood Hits	24
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

PLCG1_HUMAN
NC score	0.062909 (rank : 156)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	142	Target Neighborhood Hits	293	Shared Neighborhood Hits	21
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

CHIO_MOUSE
NC score	0.062817 (rank : 157)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	142	Target Neighborhood Hits	130	Shared Neighborhood Hits	36
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

SHAN1_HUMAN
NC score	0.062319 (rank : 158)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	142	Target Neighborhood Hits	1041	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

AHI1_HUMAN
NC score	0.062155 (rank : 159)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	142	Target Neighborhood Hits	537	Shared Neighborhood Hits	31
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

NOXO1_HUMAN
NC score	0.062045 (rank : 160)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	142	Target Neighborhood Hits	100	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

BI2L1_MOUSE
NC score	0.061634 (rank : 161)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	142	Target Neighborhood Hits	197	Shared Neighborhood Hits	27
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

TCGAP_MOUSE
NC score	0.060954 (rank : 162)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	142	Target Neighborhood Hits	409	Shared Neighborhood Hits	35
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

LASP1_HUMAN
NC score	0.060617 (rank : 163)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	142	Target Neighborhood Hits	293	Shared Neighborhood Hits	23
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

AHI1_MOUSE
NC score	0.060610 (rank : 164)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	142	Target Neighborhood Hits	496	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

CHIO_HUMAN
NC score	0.060609 (rank : 165)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	142	Target Neighborhood Hits	220	Shared Neighborhood Hits	36
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIN_MOUSE
NC score	0.060244 (rank : 166)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	142	Target Neighborhood Hits	229	Shared Neighborhood Hits	36
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

EP15R_MOUSE
NC score	0.060207 (rank : 167)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	142	Target Neighborhood Hits	1135	Shared Neighborhood Hits	41
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

DGKG_HUMAN
NC score	0.059518 (rank : 168)	θ value	4.03905 (rank : 112)
Query Neighborhood Hits	142	Target Neighborhood Hits	171	Shared Neighborhood Hits	32
SwissProt Accessions	P49619	Gene names	DGKG, DAGK3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma).

CHIN_HUMAN
NC score	0.059511 (rank : 169)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	142	Target Neighborhood Hits	227	Shared Neighborhood Hits	36
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

NPHP1_MOUSE
NC score	0.059208 (rank : 170)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	142	Target Neighborhood Hits	267	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

LASP1_MOUSE
NC score	0.058889 (rank : 171)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	142	Target Neighborhood Hits	297	Shared Neighborhood Hits	23
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

OSTF1_HUMAN
NC score	0.058595 (rank : 172)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	142	Target Neighborhood Hits	466	Shared Neighborhood Hits	24
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

REPS1_MOUSE
NC score	0.058393 (rank : 173)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	142	Target Neighborhood Hits	204	Shared Neighborhood Hits	10
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

DBNL_MOUSE
NC score	0.058269 (rank : 174)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	142	Target Neighborhood Hits	306	Shared Neighborhood Hits	21
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

NEBL_HUMAN
NC score	0.058195 (rank : 175)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	142	Target Neighborhood Hits	457	Shared Neighborhood Hits	32
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

OSTF1_MOUSE
NC score	0.057555 (rank : 176)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	142	Target Neighborhood Hits	467	Shared Neighborhood Hits	24
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

REPS1_HUMAN
NC score	0.057475 (rank : 177)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	142	Target Neighborhood Hits	205	Shared Neighborhood Hits	10
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

RHG04_HUMAN
NC score	0.057001 (rank : 178)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	142	Target Neighborhood Hits	307	Shared Neighborhood Hits	27
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

EP15R_HUMAN
NC score	0.056305 (rank : 179)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	142	Target Neighborhood Hits	1083	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

RIMB1_HUMAN
NC score	0.055798 (rank : 180)	θ value	3.0926 (rank : 107)
Query Neighborhood Hits	142	Target Neighborhood Hits	1479	Shared Neighborhood Hits	55
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB2_HUMAN
NC score	0.055647 (rank : 181)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	142	Target Neighborhood Hits	263	Shared Neighborhood Hits	23
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

PACN3_HUMAN
NC score	0.055638 (rank : 182)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	142	Target Neighborhood Hits	385	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

OBSCN_HUMAN
NC score	0.055363 (rank : 183)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	142	Target Neighborhood Hits	1931	Shared Neighborhood Hits	73
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

PCNT_HUMAN
NC score	0.054969 (rank : 184)	θ value	0.125558 (rank : 68)
Query Neighborhood Hits	142	Target Neighborhood Hits	1551	Shared Neighborhood Hits	50
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

DGKG_MOUSE
NC score	0.054920 (rank : 185)	θ value	0.813845 (rank : 81)
Query Neighborhood Hits	142	Target Neighborhood Hits	188	Shared Neighborhood Hits	29
SwissProt Accessions	Q91WG7	Gene names	Dgkg, Dagk3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma) (88 kDa diacylglycerol kinase).

NPHP1_HUMAN
NC score	0.054413 (rank : 186)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	142	Target Neighborhood Hits	288	Shared Neighborhood Hits	26
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

PACN3_MOUSE
NC score	0.054303 (rank : 187)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	142	Target Neighborhood Hits	380	Shared Neighborhood Hits	28
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

RIMB2_MOUSE
NC score	0.054302 (rank : 188)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	142	Target Neighborhood Hits	246	Shared Neighborhood Hits	20
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

BAIP2_MOUSE
NC score	0.054104 (rank : 189)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	142	Target Neighborhood Hits	185	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

DGKB_HUMAN
NC score	0.053823 (rank : 190)	θ value	6.88961 (rank : 128)
Query Neighborhood Hits	142	Target Neighborhood Hits	238	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Y6T7, O75241, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29	Gene names	DGKB, DAGK2, KIAA0718
Domain Architecture
Description	Diacylglycerol kinase beta (EC 2.7.1.107) (Diglyceride kinase beta) (DGK-beta) (DAG kinase beta) (90 kDa diacylglycerol kinase).

PACN2_MOUSE
NC score	0.053706 (rank : 191)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	142	Target Neighborhood Hits	382	Shared Neighborhood Hits	29
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

RUFY2_HUMAN
NC score	0.053604 (rank : 192)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	142	Target Neighborhood Hits	1208	Shared Neighborhood Hits	50
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

BAIP2_HUMAN
NC score	0.053532 (rank : 193)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	142	Target Neighborhood Hits	192	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

PACN2_HUMAN
NC score	0.053335 (rank : 194)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	142	Target Neighborhood Hits	339	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PLCG2_HUMAN
NC score	0.053018 (rank : 195)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	142	Target Neighborhood Hits	280	Shared Neighborhood Hits	18
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PCNT_MOUSE
NC score	0.052767 (rank : 196)	θ value	3.0926 (rank : 105)
Query Neighborhood Hits	142	Target Neighborhood Hits	1207	Shared Neighborhood Hits	46
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

EP15_HUMAN
NC score	0.052757 (rank : 197)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	142	Target Neighborhood Hits	1021	Shared Neighborhood Hits	38
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP15_MOUSE
NC score	0.052689 (rank : 198)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	142	Target Neighborhood Hits	820	Shared Neighborhood Hits	36
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

CASL_HUMAN
NC score	0.052066 (rank : 199)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	142	Target Neighborhood Hits	259	Shared Neighborhood Hits	25
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

RUFY1_MOUSE
NC score	0.052057 (rank : 200)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	142	Target Neighborhood Hits	765	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

IFT81_MOUSE
NC score	0.052021 (rank : 201)	θ value	0.47712 (rank : 76)
Query Neighborhood Hits	142	Target Neighborhood Hits	959	Shared Neighborhood Hits	37
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

TCGAP_HUMAN
NC score	0.051760 (rank : 202)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	142	Target Neighborhood Hits	872	Shared Neighborhood Hits	34
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

RUFY2_MOUSE
NC score	0.051557 (rank : 203)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	142	Target Neighborhood Hits	820	Shared Neighborhood Hits	40
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

ANM2_HUMAN
NC score	0.051458 (rank : 204)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	142	Target Neighborhood Hits	175	Shared Neighborhood Hits	20
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

RIMB1_MOUSE
NC score	0.051222 (rank : 205)	θ value	2.36792 (rank : 99)
Query Neighborhood Hits	142	Target Neighborhood Hits	1376	Shared Neighborhood Hits	53
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RUFY1_HUMAN
NC score	0.051100 (rank : 206)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	142	Target Neighborhood Hits	848	Shared Neighborhood Hits	42
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

BCAR1_MOUSE
NC score	0.050929 (rank : 207)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	142	Target Neighborhood Hits	438	Shared Neighborhood Hits	27
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

EFS_MOUSE
NC score	0.050893 (rank : 208)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	142	Target Neighborhood Hits	389	Shared Neighborhood Hits	23
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

PACN1_HUMAN
NC score	0.050484 (rank : 209)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	142	Target Neighborhood Hits	320	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

EEA1_MOUSE
NC score	0.050384 (rank : 210)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	142	Target Neighborhood Hits	1637	Shared Neighborhood Hits	58
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

CT032_HUMAN
NC score	0.050342 (rank : 211)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	142	Target Neighborhood Hits	235	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

PEX13_MOUSE
NC score	0.050324 (rank : 212)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	142	Target Neighborhood Hits	126	Shared Neighborhood Hits	15
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PACN1_MOUSE
NC score	0.050236 (rank : 213)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	142	Target Neighborhood Hits	283	Shared Neighborhood Hits	27
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

FYCO1_MOUSE
NC score	0.049678 (rank : 214)	θ value	4.03905 (rank : 113)
Query Neighborhood Hits	142	Target Neighborhood Hits	1059	Shared Neighborhood Hits	49
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

MYO9B_MOUSE
NC score	0.048245 (rank : 215)	θ value	0.000461057 (rank : 48)
Query Neighborhood Hits	142	Target Neighborhood Hits	311	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

KPCT_MOUSE
NC score	0.046883 (rank : 216)	θ value	0.00020696 (rank : 47)
Query Neighborhood Hits	142	Target Neighborhood Hits	895	Shared Neighborhood Hits	43
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

MYO9B_HUMAN
NC score	0.045713 (rank : 217)	θ value	0.00228821 (rank : 54)
Query Neighborhood Hits	142	Target Neighborhood Hits	641	Shared Neighborhood Hits	41
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

CP250_HUMAN
NC score	0.045449 (rank : 218)	θ value	6.88961 (rank : 125)
Query Neighborhood Hits	142	Target Neighborhood Hits	1805	Shared Neighborhood Hits	57
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

KPCT_HUMAN
NC score	0.045394 (rank : 219)	θ value	0.00102713 (rank : 50)
Query Neighborhood Hits	142	Target Neighborhood Hits	897	Shared Neighborhood Hits	43
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPCD_MOUSE
NC score	0.045130 (rank : 220)	θ value	0.00869519 (rank : 56)
Query Neighborhood Hits	142	Target Neighborhood Hits	888	Shared Neighborhood Hits	43
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

HMMR_HUMAN
NC score	0.043751 (rank : 221)	θ value	0.21417 (rank : 71)
Query Neighborhood Hits	142	Target Neighborhood Hits	1082	Shared Neighborhood Hits	41
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

KPCD_HUMAN
NC score	0.042912 (rank : 222)	θ value	0.0961366 (rank : 67)
Query Neighborhood Hits	142	Target Neighborhood Hits	900	Shared Neighborhood Hits	43
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCL_HUMAN
NC score	0.041632 (rank : 223)	θ value	0.0431538 (rank : 65)
Query Neighborhood Hits	142	Target Neighborhood Hits	887	Shared Neighborhood Hits	43
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KPCG_HUMAN
NC score	0.041196 (rank : 224)	θ value	6.88961 (rank : 132)
Query Neighborhood Hits	142	Target Neighborhood Hits	1126	Shared Neighborhood Hits	50
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCL_MOUSE
NC score	0.041071 (rank : 225)	θ value	0.0330416 (rank : 64)
Query Neighborhood Hits	142	Target Neighborhood Hits	891	Shared Neighborhood Hits	43
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KPCG_MOUSE
NC score	0.040689 (rank : 226)	θ value	6.88961 (rank : 133)
Query Neighborhood Hits	142	Target Neighborhood Hits	1123	Shared Neighborhood Hits	50
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

NEMO_HUMAN
NC score	0.040170 (rank : 227)	θ value	0.47712 (rank : 77)
Query Neighborhood Hits	142	Target Neighborhood Hits	820	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y6K9	Gene names	IKBKG, FIP3, NEMO
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (FIP-3).

CK5P2_HUMAN
NC score	0.039073 (rank : 228)	θ value	8.99809 (rank : 140)
Query Neighborhood Hits	142	Target Neighborhood Hits	1433	Shared Neighborhood Hits	46
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

RASF5_MOUSE
NC score	0.038303 (rank : 229)	θ value	6.88961 (rank : 136)
Query Neighborhood Hits	142	Target Neighborhood Hits	72	Shared Neighborhood Hits	26
SwissProt Accessions	Q5EBH1, O70407, Q6KAR0, Q8C2E8	Gene names	Rassf5, Nore1, Rapl
Domain Architecture	No domain graphic available
Description	Ras association domain-containing family protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL).

KPCE_HUMAN
NC score	0.037794 (rank : 230)	θ value	1.38821 (rank : 87)
Query Neighborhood Hits	142	Target Neighborhood Hits	906	Shared Neighborhood Hits	43
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCE_MOUSE
NC score	0.037749 (rank : 231)	θ value	1.38821 (rank : 88)
Query Neighborhood Hits	142	Target Neighborhood Hits	906	Shared Neighborhood Hits	43
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

CROCC_MOUSE
NC score	0.035938 (rank : 232)	θ value	2.36792 (rank : 94)
Query Neighborhood Hits	142	Target Neighborhood Hits	1460	Shared Neighborhood Hits	47
SwissProt Accessions	Q8CJ40, Q7TQL2, Q80U01, Q8R0B9	Gene names	Crocc, Kiaa0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

KPCZ_HUMAN
NC score	0.035232 (rank : 233)	θ value	2.36792 (rank : 96)
Query Neighborhood Hits	142	Target Neighborhood Hits	884	Shared Neighborhood Hits	43
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KTN1_MOUSE
NC score	0.034500 (rank : 234)	θ value	0.813845 (rank : 82)
Query Neighborhood Hits	142	Target Neighborhood Hits	1324	Shared Neighborhood Hits	45
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

PEPL_MOUSE
NC score	0.034165 (rank : 235)	θ value	3.0926 (rank : 106)
Query Neighborhood Hits	142	Target Neighborhood Hits	1105	Shared Neighborhood Hits	43
SwissProt Accessions	Q9R269, O70231, Q9CUT1, Q9JLZ7	Gene names	Ppl
Domain Architecture
Description	Periplakin.

NEMO_MOUSE
NC score	0.033991 (rank : 236)	θ value	6.88961 (rank : 135)
Query Neighborhood Hits	142	Target Neighborhood Hits	658	Shared Neighborhood Hits	33
SwissProt Accessions	O88522	Gene names	Ikbkg, Nemo
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3).

CB010_HUMAN
NC score	0.033982 (rank : 237)	θ value	3.0926 (rank : 101)
Query Neighborhood Hits	142	Target Neighborhood Hits	130	Shared Neighborhood Hits	9
SwissProt Accessions	Q7Z570, Q6ZN26	Gene names	C2orf10
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf10.

MAT1_HUMAN
NC score	0.033374 (rank : 238)	θ value	5.27518 (rank : 121)
Query Neighborhood Hits	142	Target Neighborhood Hits	179	Shared Neighborhood Hits	8
SwissProt Accessions	P51948, Q15817	Gene names	MNAT1, CAP35, MAT1, RNF66
Domain Architecture
Description	CDK-activating kinase assembly factor MAT1 (RING finger protein MAT1) (Menage a trois) (CDK7/cyclin H assembly factor) (p36) (p35) (Cyclin G1-interacting protein) (RING finger protein 66).

USE1_HUMAN
NC score	0.033371 (rank : 239)	θ value	0.47712 (rank : 78)
Query Neighborhood Hits	142	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZ43, Q8NCK1, Q9BRT4	Gene names	USE1L
Domain Architecture	No domain graphic available
Description	Vesicle transport protein USE1 (USE1-like protein) (Putative MAPK- activating protein PM26) (Protein p31).

KPCZ_MOUSE
NC score	0.033233 (rank : 240)	θ value	8.99809 (rank : 142)
Query Neighborhood Hits	142	Target Neighborhood Hits	882	Shared Neighborhood Hits	43
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

MAT1_MOUSE
NC score	0.032915 (rank : 241)	θ value	5.27518 (rank : 122)
Query Neighborhood Hits	142	Target Neighborhood Hits	217	Shared Neighborhood Hits	11
SwissProt Accessions	P51949, Q3TZP0, Q9D8A0, Q9D8D2	Gene names	Mnat1, Mat1
Domain Architecture
Description	CDK-activating kinase assembly factor MAT1 (RING finger protein MAT1) (Menage a trois) (CDK7/cyclin H assembly factor) (p36) (p35).

MRCKG_HUMAN
NC score	0.032664 (rank : 242)	θ value	0.279714 (rank : 73)
Query Neighborhood Hits	142	Target Neighborhood Hits	1519	Shared Neighborhood Hits	64
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

MACOI_HUMAN
NC score	0.030614 (rank : 243)	θ value	5.27518 (rank : 119)
Query Neighborhood Hits	142	Target Neighborhood Hits	650	Shared Neighborhood Hits	32
SwissProt Accessions	Q8N5G2, Q2TLX5, Q2TLX6, Q9NVG6	Gene names	TMEM57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57).

GOGA5_HUMAN
NC score	0.030391 (rank : 244)	θ value	6.88961 (rank : 129)
Query Neighborhood Hits	142	Target Neighborhood Hits	1168	Shared Neighborhood Hits	41
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

CING_HUMAN
NC score	0.030025 (rank : 245)	θ value	1.81305 (rank : 91)
Query Neighborhood Hits	142	Target Neighborhood Hits	1275	Shared Neighborhood Hits	43
SwissProt Accessions	Q9P2M7, Q5T386, Q9NR25	Gene names	CGN, KIAA1319
Domain Architecture
Description	Cingulin.

MACOI_MOUSE
NC score	0.029512 (rank : 246)	θ value	5.27518 (rank : 120)
Query Neighborhood Hits	142	Target Neighborhood Hits	620	Shared Neighborhood Hits	32
SwissProt Accessions	Q7TQE6	Gene names	Tmem57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57) (Brain-specific adaptor protein C61).

CGAT1_HUMAN
NC score	0.029304 (rank : 247)	θ value	0.279714 (rank : 72)
Query Neighborhood Hits	142	Target Neighborhood Hits	69	Shared Neighborhood Hits	7
SwissProt Accessions	Q8TDX6, Q6P9G6, Q8IUF9, Q9NSQ7, Q9NUM9	Gene names	GALNACT1, CHGN
Domain Architecture	No domain graphic available
Description	Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1 (EC 2.4.1.174) (beta4GalNAcT-1).

IL33_MOUSE
NC score	0.028601 (rank : 248)	θ value	6.88961 (rank : 130)
Query Neighborhood Hits	142	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BVZ5, Q2YEJ4, Q3TQN0, Q99L46	Gene names	Il33
Domain Architecture	No domain graphic available
Description	Interleukin-33 precursor (IL-33).

TEX9_MOUSE
NC score	0.027259 (rank : 249)	θ value	6.88961 (rank : 138)
Query Neighborhood Hits	142	Target Neighborhood Hits	581	Shared Neighborhood Hits	31
SwissProt Accessions	Q9D845, O54764	Gene names	Tex9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein (Testis-specifically expressed protein 1) (Tsec-1).

SLK_MOUSE
NC score	0.026893 (rank : 250)	θ value	0.813845 (rank : 83)
Query Neighborhood Hits	142	Target Neighborhood Hits	1798	Shared Neighborhood Hits	55
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

CGAT1_MOUSE
NC score	0.026426 (rank : 251)	θ value	0.813845 (rank : 80)
Query Neighborhood Hits	142	Target Neighborhood Hits	61	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BJQ9, Q3UZX6, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6	Gene names	Galnact1, Chgn
Domain Architecture	No domain graphic available
Description	Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1 (EC 2.4.1.174) (beta4GalNAcT-1).

BPA1_MOUSE
NC score	0.026295 (rank : 252)	θ value	1.81305 (rank : 90)
Query Neighborhood Hits	142	Target Neighborhood Hits	1477	Shared Neighborhood Hits	45
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

SLK_HUMAN
NC score	0.024767 (rank : 253)	θ value	1.06291 (rank : 85)
Query Neighborhood Hits	142	Target Neighborhood Hits	1775	Shared Neighborhood Hits	50
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

CKAP4_HUMAN
NC score	0.023700 (rank : 254)	θ value	1.38821 (rank : 86)
Query Neighborhood Hits	142	Target Neighborhood Hits	592	Shared Neighborhood Hits	27
SwissProt Accessions	Q07065, Q504S5, Q53ES6	Gene names	CKAP4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

MLL3_MOUSE
NC score	0.022570 (rank : 255)	θ value	1.81305 (rank : 93)
Query Neighborhood Hits	142	Target Neighborhood Hits	1399	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

CUTL2_HUMAN
NC score	0.021617 (rank : 256)	θ value	2.36792 (rank : 95)
Query Neighborhood Hits	142	Target Neighborhood Hits	906	Shared Neighborhood Hits	30
SwissProt Accessions	O14529	Gene names	CUTL2, KIAA0293
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

K0100_HUMAN
NC score	0.021601 (rank : 257)	θ value	5.27518 (rank : 118)
Query Neighborhood Hits	142	Target Neighborhood Hits	132	Shared Neighborhood Hits	13
SwissProt Accessions	Q14667, Q3SYN5, Q49A07, Q5H9T4, Q6WG74, Q6ZP51, Q96HH8	Gene names	KIAA0100, BCOX1
Domain Architecture	No domain graphic available
Description	UPF0378 family protein KIAA0100 precursor (Breast cancer overexpressed gene 1 protein) (Antigen MLAA-22).

CCD50_HUMAN
NC score	0.021204 (rank : 258)	θ value	5.27518 (rank : 115)
Query Neighborhood Hits	142	Target Neighborhood Hits	237	Shared Neighborhood Hits	15
SwissProt Accessions	Q8IVM0, Q86VH7	Gene names	CCDC50, C3orf6
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 50 (Protein Ymer).

MLL3_HUMAN
NC score	0.020747 (rank : 259)	θ value	1.81305 (rank : 92)
Query Neighborhood Hits	142	Target Neighborhood Hits	1644	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

CCD93_HUMAN
NC score	0.020185 (rank : 260)	θ value	8.99809 (rank : 139)
Query Neighborhood Hits	142	Target Neighborhood Hits	600	Shared Neighborhood Hits	22
SwissProt Accessions	Q567U6, Q4LE78, Q53TJ2, Q8TBX5, Q9H6R5, Q9NV15	Gene names	CCDC93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

AKT1_HUMAN
NC score	0.019490 (rank : 261)	θ value	4.03905 (rank : 110)
Query Neighborhood Hits	142	Target Neighborhood Hits	885	Shared Neighborhood Hits	22
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

CHFR_HUMAN
NC score	0.019091 (rank : 262)	θ value	4.03905 (rank : 111)
Query Neighborhood Hits	142	Target Neighborhood Hits	255	Shared Neighborhood Hits	4
SwissProt Accessions	Q96EP1, Q96SL3, Q9NRT4, Q9NT32, Q9NVD5	Gene names	CHFR
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

K0100_MOUSE
NC score	0.018918 (rank : 263)	θ value	6.88961 (rank : 131)
Query Neighborhood Hits	142	Target Neighborhood Hits	111	Shared Neighborhood Hits	12
SwissProt Accessions	Q5SYL3, Q3UE65, Q66JY1, Q6DIC4, Q80U77, Q8C1W6, Q8CE06, Q8CGE3, Q9CSS8	Gene names	Kiaa0100
Domain Architecture	No domain graphic available
Description	UPF0378 family protein KIAA0100 precursor.

CUTL2_MOUSE
NC score	0.018902 (rank : 264)	θ value	5.27518 (rank : 116)
Query Neighborhood Hits	142	Target Neighborhood Hits	771	Shared Neighborhood Hits	25
SwissProt Accessions	P70298	Gene names	Cutl2
Domain Architecture
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

KLC4_HUMAN
NC score	0.016887 (rank : 265)	θ value	3.0926 (rank : 104)
Query Neighborhood Hits	142	Target Neighborhood Hits	327	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NSK0	Gene names	KLC4, KNSL8
Domain Architecture
Description	Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8).

TBCD4_HUMAN
NC score	0.016262 (rank : 266)	θ value	3.0926 (rank : 108)
Query Neighborhood Hits	142	Target Neighborhood Hits	357	Shared Neighborhood Hits	13
SwissProt Accessions	O60343, Q5W0B9	Gene names	TBC1D4, KIAA0603
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160).

TAOK2_HUMAN
NC score	0.015308 (rank : 267)	θ value	1.38821 (rank : 89)
Query Neighborhood Hits	142	Target Neighborhood Hits	1172	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

CHFR_MOUSE
NC score	0.015067 (rank : 268)	θ value	6.88961 (rank : 124)
Query Neighborhood Hits	142	Target Neighborhood Hits	264	Shared Neighborhood Hits	5
SwissProt Accessions	Q810L3, Q8BJZ9, Q8BWH4	Gene names	Chfr
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

LIMA1_HUMAN
NC score	0.012258 (rank : 269)	θ value	2.36792 (rank : 97)
Query Neighborhood Hits	142	Target Neighborhood Hits	309	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UHB6, Q2TAN7, Q9BVF2, Q9H8J1, Q9HBN5, Q9NX96, Q9NXC3, Q9NXU6, Q9P0H8, Q9UHB5	Gene names	LIMA1, EPLIN, SREBP3
Domain Architecture
Description	LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm).

DD19A_HUMAN
NC score	0.009423 (rank : 270)	θ value	3.0926 (rank : 102)
Query Neighborhood Hits	142	Target Neighborhood Hits	107	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NUU7, Q53FM0	Gene names	DDX19A, DDX19L
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DDX19-like protein).

TESK1_HUMAN
NC score	0.008477 (rank : 271)	θ value	6.88961 (rank : 137)
Query Neighborhood Hits	142	Target Neighborhood Hits	864	Shared Neighborhood Hits	22
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

KIF3C_MOUSE
NC score	0.008470 (rank : 272)	θ value	8.99809 (rank : 141)
Query Neighborhood Hits	142	Target Neighborhood Hits	468	Shared Neighborhood Hits	29
SwissProt Accessions	O35066, O35229	Gene names	Kif3c
Domain Architecture
Description	Kinesin-like protein KIF3C.

CSKI2_MOUSE
NC score	0.007854 (rank : 273)	θ value	6.88961 (rank : 126)
Query Neighborhood Hits	142	Target Neighborhood Hits	812	Shared Neighborhood Hits	16
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

DD19B_HUMAN
NC score	0.007680 (rank : 274)	θ value	3.0926 (rank : 103)
Query Neighborhood Hits	142	Target Neighborhood Hits	109	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UMR2, Q6FIB7, Q6IAE0	Gene names	DDX19B, DBP5, DDX19
Domain Architecture
Description	ATP-dependent RNA helicase DDX19B (EC 3.6.1.-) (DEAD box protein 19B) (DEAD box RNA helicase DEAD5).

MYOD1_HUMAN
NC score	0.006872 (rank : 275)	θ value	6.88961 (rank : 134)
Query Neighborhood Hits	142	Target Neighborhood Hits	100	Shared Neighborhood Hits	2
SwissProt Accessions	P15172	Gene names	MYOD1, MYF3, MYOD
Domain Architecture
Description	Myoblast determination protein 1 (Myogenic factor 3) (Myf-3).

DD19A_MOUSE
NC score	0.006617 (rank : 276)	θ value	6.88961 (rank : 127)
Query Neighborhood Hits	142	Target Neighborhood Hits	105	Shared Neighborhood Hits	4
SwissProt Accessions	Q61655, Q921R0	Gene names	Ddx19a, Ddx19, Eif4a-rs1
Domain Architecture
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DEAD box RNA helicase DEAD5) (mDEAD5) (Eukaryotic translation initiation factor 4A-related sequence 1).

SDK1_HUMAN
NC score	0.002462 (rank : 277)	θ value	5.27518 (rank : 123)
Query Neighborhood Hits	142	Target Neighborhood Hits	511	Shared Neighborhood Hits	9
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.