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Network neighborhood for query Sequence : LBC_HUMAN

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LBC_HUMAN
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

LBC_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	90	Target Neighborhood Hits	90	Shared Neighborhood Hits	90
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHG2_MOUSE
θ value	2.79562e-118 (rank : 2)	NC score	0.946664 (rank : 2)
Query Neighborhood Hits	90	Target Neighborhood Hits	120	Shared Neighborhood Hits	57
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

RGNEF_MOUSE
θ value	7.12574e-114 (rank : 3)	NC score	0.802084 (rank : 6)
Query Neighborhood Hits	90	Target Neighborhood Hits	641	Shared Neighborhood Hits	67
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ARHG2_HUMAN
θ value	2.29227e-112 (rank : 4)	NC score	0.942818 (rank : 3)
Query Neighborhood Hits	90	Target Neighborhood Hits	142	Shared Neighborhood Hits	56
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG1_HUMAN
θ value	8.87376e-48 (rank : 5)	NC score	0.864964 (rank : 4)
Query Neighborhood Hits	90	Target Neighborhood Hits	176	Shared Neighborhood Hits	56
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	7.03111e-45 (rank : 6)	NC score	0.842877 (rank : 5)
Query Neighborhood Hits	90	Target Neighborhood Hits	266	Shared Neighborhood Hits	52
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHGB_HUMAN
θ value	7.27602e-42 (rank : 7)	NC score	0.776583 (rank : 9)
Query Neighborhood Hits	90	Target Neighborhood Hits	375	Shared Neighborhood Hits	59
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	2.11701e-41 (rank : 8)	NC score	0.787216 (rank : 8)
Query Neighborhood Hits	90	Target Neighborhood Hits	351	Shared Neighborhood Hits	61
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	3.37985e-39 (rank : 9)	NC score	0.788539 (rank : 7)
Query Neighborhood Hits	90	Target Neighborhood Hits	344	Shared Neighborhood Hits	63
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHG8_MOUSE
θ value	8.95645e-16 (rank : 10)	NC score	0.664576 (rank : 13)
Query Neighborhood Hits	90	Target Neighborhood Hits	79	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHG3_HUMAN
θ value	1.99529e-15 (rank : 11)	NC score	0.706413 (rank : 11)
Query Neighborhood Hits	90	Target Neighborhood Hits	82	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	4.44505e-15 (rank : 12)	NC score	0.706650 (rank : 10)
Query Neighborhood Hits	90	Target Neighborhood Hits	85	Shared Neighborhood Hits	53
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ITSN1_HUMAN
θ value	1.09485e-13 (rank : 13)	NC score	0.412180 (rank : 47)
Query Neighborhood Hits	90	Target Neighborhood Hits	1757	Shared Neighborhood Hits	73
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

FGD4_HUMAN
θ value	7.09661e-13 (rank : 14)	NC score	0.538370 (rank : 24)
Query Neighborhood Hits	90	Target Neighborhood Hits	219	Shared Neighborhood Hits	58
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

ITSN2_HUMAN
θ value	7.09661e-13 (rank : 15)	NC score	0.450122 (rank : 38)
Query Neighborhood Hits	90	Target Neighborhood Hits	1173	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ARHG8_HUMAN
θ value	1.58096e-12 (rank : 16)	NC score	0.674359 (rank : 12)
Query Neighborhood Hits	90	Target Neighborhood Hits	85	Shared Neighborhood Hits	55
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

FGD4_MOUSE
θ value	1.58096e-12 (rank : 17)	NC score	0.535317 (rank : 27)
Query Neighborhood Hits	90	Target Neighborhood Hits	227	Shared Neighborhood Hits	58
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

ITSN1_MOUSE
θ value	1.58096e-12 (rank : 18)	NC score	0.409249 (rank : 48)
Query Neighborhood Hits	90	Target Neighborhood Hits	1669	Shared Neighborhood Hits	71
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_MOUSE
θ value	3.52202e-12 (rank : 19)	NC score	0.425218 (rank : 42)
Query Neighborhood Hits	90	Target Neighborhood Hits	1371	Shared Neighborhood Hits	72
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

FGD1_MOUSE
θ value	4.59992e-12 (rank : 20)	NC score	0.528508 (rank : 29)
Query Neighborhood Hits	90	Target Neighborhood Hits	387	Shared Neighborhood Hits	56
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ARHGG_HUMAN
θ value	8.67504e-11 (rank : 21)	NC score	0.629764 (rank : 14)
Query Neighborhood Hits	90	Target Neighborhood Hits	129	Shared Neighborhood Hits	57
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

FGD1_HUMAN
θ value	1.47974e-10 (rank : 22)	NC score	0.523024 (rank : 31)
Query Neighborhood Hits	90	Target Neighborhood Hits	367	Shared Neighborhood Hits	58
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD3_MOUSE
θ value	1.47974e-10 (rank : 23)	NC score	0.574274 (rank : 19)
Query Neighborhood Hits	90	Target Neighborhood Hits	257	Shared Neighborhood Hits	57
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD3_HUMAN
θ value	1.9326e-10 (rank : 24)	NC score	0.542542 (rank : 23)
Query Neighborhood Hits	90	Target Neighborhood Hits	249	Shared Neighborhood Hits	57
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD2_HUMAN
θ value	7.34386e-10 (rank : 25)	NC score	0.536571 (rank : 26)
Query Neighborhood Hits	90	Target Neighborhood Hits	151	Shared Neighborhood Hits	56
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	7.34386e-10 (rank : 26)	NC score	0.543262 (rank : 22)
Query Neighborhood Hits	90	Target Neighborhood Hits	163	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

ARHG5_HUMAN
θ value	6.21693e-09 (rank : 27)	NC score	0.597664 (rank : 16)
Query Neighborhood Hits	90	Target Neighborhood Hits	172	Shared Neighborhood Hits	56
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHGG_MOUSE
θ value	1.06045e-08 (rank : 28)	NC score	0.608055 (rank : 15)
Query Neighborhood Hits	90	Target Neighborhood Hits	152	Shared Neighborhood Hits	57
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

DNMBP_MOUSE
θ value	2.36244e-08 (rank : 29)	NC score	0.434113 (rank : 40)
Query Neighborhood Hits	90	Target Neighborhood Hits	435	Shared Neighborhood Hits	59
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_HUMAN
θ value	4.0297e-08 (rank : 30)	NC score	0.427433 (rank : 41)
Query Neighborhood Hits	90	Target Neighborhood Hits	413	Shared Neighborhood Hits	60
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHGF_HUMAN
θ value	1.99992e-07 (rank : 31)	NC score	0.565028 (rank : 20)
Query Neighborhood Hits	90	Target Neighborhood Hits	214	Shared Neighborhood Hits	51
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

VAV3_MOUSE
θ value	4.92598e-06 (rank : 32)	NC score	0.388232 (rank : 52)
Query Neighborhood Hits	90	Target Neighborhood Hits	404	Shared Neighborhood Hits	55
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ARHG9_HUMAN
θ value	1.43324e-05 (rank : 33)	NC score	0.506256 (rank : 33)
Query Neighborhood Hits	90	Target Neighborhood Hits	235	Shared Neighborhood Hits	56
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	1.43324e-05 (rank : 34)	NC score	0.504579 (rank : 34)
Query Neighborhood Hits	90	Target Neighborhood Hits	234	Shared Neighborhood Hits	56
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ECT2_HUMAN
θ value	1.43324e-05 (rank : 35)	NC score	0.578767 (rank : 18)
Query Neighborhood Hits	90	Target Neighborhood Hits	98	Shared Neighborhood Hits	58
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

VAV3_HUMAN
θ value	1.87187e-05 (rank : 36)	NC score	0.385359 (rank : 53)
Query Neighborhood Hits	90	Target Neighborhood Hits	398	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ECT2_MOUSE
θ value	3.19293e-05 (rank : 37)	NC score	0.593467 (rank : 17)
Query Neighborhood Hits	90	Target Neighborhood Hits	98	Shared Neighborhood Hits	59
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

VAV_MOUSE
θ value	3.19293e-05 (rank : 38)	NC score	0.418389 (rank : 45)
Query Neighborhood Hits	90	Target Neighborhood Hits	430	Shared Neighborhood Hits	57
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

TIAM1_MOUSE
θ value	4.1701e-05 (rank : 39)	NC score	0.524900 (rank : 30)
Query Neighborhood Hits	90	Target Neighborhood Hits	205	Shared Neighborhood Hits	56
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

VAV2_HUMAN
θ value	7.1131e-05 (rank : 40)	NC score	0.423260 (rank : 43)
Query Neighborhood Hits	90	Target Neighborhood Hits	453	Shared Neighborhood Hits	59
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	0.000121331 (rank : 41)	NC score	0.420009 (rank : 44)
Query Neighborhood Hits	90	Target Neighborhood Hits	456	Shared Neighborhood Hits	59
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

TIAM1_HUMAN
θ value	0.000158464 (rank : 42)	NC score	0.512628 (rank : 32)
Query Neighborhood Hits	90	Target Neighborhood Hits	225	Shared Neighborhood Hits	56
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG7_HUMAN
θ value	0.00020696 (rank : 43)	NC score	0.333349 (rank : 57)
Query Neighborhood Hits	90	Target Neighborhood Hits	347	Shared Neighborhood Hits	53
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

VAV_HUMAN
θ value	0.00035302 (rank : 44)	NC score	0.400833 (rank : 51)
Query Neighborhood Hits	90	Target Neighborhood Hits	452	Shared Neighborhood Hits	58
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

MCF2L_MOUSE
θ value	0.000461057 (rank : 45)	NC score	0.417837 (rank : 46)
Query Neighborhood Hits	90	Target Neighborhood Hits	255	Shared Neighborhood Hits	63
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

FGD6_MOUSE
θ value	0.000786445 (rank : 46)	NC score	0.406785 (rank : 49)
Query Neighborhood Hits	90	Target Neighborhood Hits	282	Shared Neighborhood Hits	55
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

PREX1_HUMAN
θ value	0.00102713 (rank : 47)	NC score	0.534363 (rank : 28)
Query Neighborhood Hits	90	Target Neighborhood Hits	177	Shared Neighborhood Hits	57
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ARHG4_HUMAN
θ value	0.00228821 (rank : 48)	NC score	0.481941 (rank : 36)
Query Neighborhood Hits	90	Target Neighborhood Hits	242	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

FARP1_HUMAN
θ value	0.00228821 (rank : 49)	NC score	0.289501 (rank : 63)
Query Neighborhood Hits	90	Target Neighborhood Hits	241	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

TRIO_HUMAN
θ value	0.00228821 (rank : 50)	NC score	0.147005 (rank : 72)
Query Neighborhood Hits	90	Target Neighborhood Hits	1580	Shared Neighborhood Hits	70
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

FGD6_HUMAN
θ value	0.00665767 (rank : 51)	NC score	0.404113 (rank : 50)
Query Neighborhood Hits	90	Target Neighborhood Hits	237	Shared Neighborhood Hits	52
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

CU013_HUMAN
θ value	0.00869519 (rank : 52)	NC score	0.061447 (rank : 155)
Query Neighborhood Hits	90	Target Neighborhood Hits	405	Shared Neighborhood Hits	23
SwissProt Accessions	O95447	Gene names	C21orf13
Domain Architecture
Description	Protein C21orf13.

DUET_HUMAN
θ value	0.00869519 (rank : 53)	NC score	0.152631 (rank : 71)
Query Neighborhood Hits	90	Target Neighborhood Hits	1220	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

ARHG4_MOUSE
θ value	0.0193708 (rank : 54)	NC score	0.498306 (rank : 35)
Query Neighborhood Hits	90	Target Neighborhood Hits	185	Shared Neighborhood Hits	56
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

MCF2_HUMAN
θ value	0.0252991 (rank : 55)	NC score	0.446588 (rank : 39)
Query Neighborhood Hits	90	Target Neighborhood Hits	166	Shared Neighborhood Hits	58
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

HAPIP_HUMAN
θ value	0.0330416 (rank : 56)	NC score	0.344382 (rank : 56)
Query Neighborhood Hits	90	Target Neighborhood Hits	350	Shared Neighborhood Hits	64
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ARHG7_MOUSE
θ value	0.0563607 (rank : 57)	NC score	0.306603 (rank : 60)
Query Neighborhood Hits	90	Target Neighborhood Hits	396	Shared Neighborhood Hits	54
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

FGD5_HUMAN
θ value	0.0563607 (rank : 58)	NC score	0.310361 (rank : 59)
Query Neighborhood Hits	90	Target Neighborhood Hits	235	Shared Neighborhood Hits	39
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

CTRO_MOUSE
θ value	0.125558 (rank : 59)	NC score	0.022586 (rank : 218)
Query Neighborhood Hits	90	Target Neighborhood Hits	2344	Shared Neighborhood Hits	36
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

DEN2C_MOUSE
θ value	0.279714 (rank : 60)	NC score	0.017928 (rank : 222)
Query Neighborhood Hits	90	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	Q6P9P8, Q3T9X2, Q3UV30, Q80V46	Gene names	Dennd2c
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2C.

C8AP2_MOUSE
θ value	0.62314 (rank : 61)	NC score	0.024018 (rank : 216)
Query Neighborhood Hits	90	Target Neighborhood Hits	405	Shared Neighborhood Hits	10
SwissProt Accessions	Q9WUF3, Q9CSW2	Gene names	Casp8ap2, Flash
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

CTRO_HUMAN
θ value	0.62314 (rank : 62)	NC score	0.018913 (rank : 219)
Query Neighborhood Hits	90	Target Neighborhood Hits	2092	Shared Neighborhood Hits	34
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

IFT81_MOUSE
θ value	0.62314 (rank : 63)	NC score	0.050135 (rank : 203)
Query Neighborhood Hits	90	Target Neighborhood Hits	959	Shared Neighborhood Hits	26
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

CHSTA_HUMAN
θ value	1.81305 (rank : 64)	NC score	0.018638 (rank : 220)
Query Neighborhood Hits	90	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	O43529	Gene names	CHST10
Domain Architecture	No domain graphic available
Description	Carbohydrate sulfotransferase 10 (EC 2.8.2.-) (HNK-1 sulfotransferase) (HNK1ST) (HNK-1ST) (huHNK-1ST).

DPOLM_MOUSE
θ value	1.81305 (rank : 65)	NC score	0.014940 (rank : 224)
Query Neighborhood Hits	90	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JIW4, Q9JJW9	Gene names	Polm
Domain Architecture
Description	DNA polymerase mu (EC 2.7.7.7) (Pol Mu).

PEPL_HUMAN
θ value	1.81305 (rank : 66)	NC score	0.028417 (rank : 212)
Query Neighborhood Hits	90	Target Neighborhood Hits	1141	Shared Neighborhood Hits	26
SwissProt Accessions	O60437, O60314, O60454	Gene names	PPL, KIAA0568
Domain Architecture
Description	Periplakin (195 kDa cornified envelope precursor protein) (190 kDa paraneoplastic pemphigus antigen).

MACF1_HUMAN
θ value	2.36792 (rank : 67)	NC score	0.022914 (rank : 217)
Query Neighborhood Hits	90	Target Neighborhood Hits	1341	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

CENPE_HUMAN
θ value	3.0926 (rank : 68)	NC score	0.025416 (rank : 215)
Query Neighborhood Hits	90	Target Neighborhood Hits	2060	Shared Neighborhood Hits	40
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

CHSTA_MOUSE
θ value	4.03905 (rank : 69)	NC score	0.016455 (rank : 223)
Query Neighborhood Hits	90	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PGK7, Q8BKU3, Q8BL08, Q8R2Y5, Q91Y40	Gene names	Chst10
Domain Architecture	No domain graphic available
Description	Carbohydrate sulfotransferase 10 (EC 2.8.2.-) (HNK-1 sulfotransferase) (HNK1ST) (HNK-1ST).

IFT81_HUMAN
θ value	4.03905 (rank : 70)	NC score	0.033283 (rank : 208)
Query Neighborhood Hits	90	Target Neighborhood Hits	893	Shared Neighborhood Hits	24
SwissProt Accessions	Q8WYA0, Q8NB51, Q9BSV2, Q9UNY8	Gene names	IFT81, CDV1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

LRC45_MOUSE
θ value	4.03905 (rank : 71)	NC score	0.035194 (rank : 207)
Query Neighborhood Hits	90	Target Neighborhood Hits	959	Shared Neighborhood Hits	23
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

MRCKA_HUMAN
θ value	4.03905 (rank : 72)	NC score	0.018454 (rank : 221)
Query Neighborhood Hits	90	Target Neighborhood Hits	1999	Shared Neighborhood Hits	37
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

NOG2_HUMAN
θ value	4.03905 (rank : 73)	NC score	0.013497 (rank : 226)
Query Neighborhood Hits	90	Target Neighborhood Hits	117	Shared Neighborhood Hits	8
SwissProt Accessions	Q13823, Q9BWN7	Gene names	GNL2, NGP1
Domain Architecture
Description	Nucleolar GTP-binding protein 2 (Autoantigen NGP-1).

RB6I2_HUMAN
θ value	4.03905 (rank : 74)	NC score	0.035776 (rank : 206)
Query Neighborhood Hits	90	Target Neighborhood Hits	1584	Shared Neighborhood Hits	32
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

RB6I2_MOUSE
θ value	4.03905 (rank : 75)	NC score	0.037561 (rank : 205)
Query Neighborhood Hits	90	Target Neighborhood Hits	1433	Shared Neighborhood Hits	29
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

IQGA2_HUMAN
θ value	5.27518 (rank : 76)	NC score	0.009300 (rank : 231)
Query Neighborhood Hits	90	Target Neighborhood Hits	200	Shared Neighborhood Hits	9
SwissProt Accessions	Q13576	Gene names	IQGAP2
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP2.

ERC2_HUMAN
θ value	6.88961 (rank : 77)	NC score	0.031886 (rank : 210)
Query Neighborhood Hits	90	Target Neighborhood Hits	1156	Shared Neighborhood Hits	27
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

ERC2_MOUSE
θ value	6.88961 (rank : 78)	NC score	0.032809 (rank : 209)
Query Neighborhood Hits	90	Target Neighborhood Hits	1166	Shared Neighborhood Hits	28
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

EXOC4_MOUSE
θ value	6.88961 (rank : 79)	NC score	0.026328 (rank : 213)
Query Neighborhood Hits	90	Target Neighborhood Hits	86	Shared Neighborhood Hits	7
SwissProt Accessions	O35382	Gene names	Exoc4, Sec8, Sec8l1
Domain Architecture
Description	Exocyst complex component 4 (Exocyst complex component Sec8).

QKI_HUMAN
θ value	6.88961 (rank : 80)	NC score	0.012969 (rank : 229)
Query Neighborhood Hits	90	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	Q96PU8, Q2I375, Q5MJQ1, Q969L9, Q96EJ3, Q96KA3, Q96PU6, Q96PU7, Q9P0X6, Q9P0X7, Q9P0X8, Q9P0X9, Q9P0Y0, Q9P0Y1	Gene names	QKI, HKQ
Domain Architecture	No domain graphic available
Description	Quaking protein (Hqk).

QKI_MOUSE
θ value	6.88961 (rank : 81)	NC score	0.012969 (rank : 230)
Query Neighborhood Hits	90	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QYS9, O88972, Q61110, Q78ZE4, Q78ZE5, Q8K4X9, Q8K4Y0, Q9CW34, Q9QUH4, Q9R2A8, Q9Z246	Gene names	Qki, Qk, Qk1, Qka1
Domain Architecture	No domain graphic available
Description	Quaking protein (qkI).

TRI25_HUMAN
θ value	6.88961 (rank : 82)	NC score	0.003288 (rank : 234)
Query Neighborhood Hits	90	Target Neighborhood Hits	472	Shared Neighborhood Hits	8
SwissProt Accessions	Q14258	Gene names	TRIM25, EFP, RNF147, ZNF147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp) (RING finger protein 147).

EXOC4_HUMAN
θ value	8.99809 (rank : 83)	NC score	0.025504 (rank : 214)
Query Neighborhood Hits	90	Target Neighborhood Hits	72	Shared Neighborhood Hits	7
SwissProt Accessions	Q96A65, Q9C0G4, Q9H9K0, Q9P102	Gene names	EXOC4, KIAA1699, SEC8, SEC8L1
Domain Architecture
Description	Exocyst complex component 4 (Exocyst complex component Sec8).

FBX43_MOUSE
θ value	8.99809 (rank : 84)	NC score	0.008238 (rank : 232)
Query Neighborhood Hits	90	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CDI2, Q4G0C8, Q8R0R1	Gene names	Fbxo43, Emi2
Domain Architecture	No domain graphic available
Description	F-box only protein 43 (Endogenous meiotic inhibitor 2).

GOGA4_HUMAN
θ value	8.99809 (rank : 85)	NC score	0.028991 (rank : 211)
Query Neighborhood Hits	90	Target Neighborhood Hits	2034	Shared Neighborhood Hits	36
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

SFRIP_HUMAN
θ value	8.99809 (rank : 86)	NC score	0.007273 (rank : 233)
Query Neighborhood Hits	90	Target Neighborhood Hits	530	Shared Neighborhood Hits	8
SwissProt Accessions	Q99590, Q8IW59	Gene names	SFRS2IP, CASP11, SIP1
Domain Architecture	No domain graphic available
Description	SFRS2-interacting protein (Splicing factor, arginine/serine-rich 2- interacting protein) (SC35-interacting protein 1) (CTD-associated SR protein 11) (Splicing regulatory protein 129) (SRrp129) (NY-REN-40 antigen).

STCH_MOUSE
θ value	8.99809 (rank : 87)	NC score	0.003036 (rank : 235)
Query Neighborhood Hits	90	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BM72, Q3TII6, Q9D1X5	Gene names	Stch
Domain Architecture	No domain graphic available
Description	Stress 70 protein chaperone microsome-associated 60 kDa protein precursor (Microsomal stress 70 protein ATPase core).

TBCD4_HUMAN
θ value	8.99809 (rank : 88)	NC score	0.013210 (rank : 227)
Query Neighborhood Hits	90	Target Neighborhood Hits	357	Shared Neighborhood Hits	14
SwissProt Accessions	O60343, Q5W0B9	Gene names	TBC1D4, KIAA0603
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160).

TMCC2_HUMAN
θ value	8.99809 (rank : 89)	NC score	0.013112 (rank : 228)
Query Neighborhood Hits	90	Target Neighborhood Hits	227	Shared Neighborhood Hits	14
SwissProt Accessions	O75069, Q6ZN09	Gene names	TMCC2, KIAA0481
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domains protein 2 (Cerebral protein 11).

TMCC2_MOUSE
θ value	8.99809 (rank : 90)	NC score	0.013997 (rank : 225)
Query Neighborhood Hits	90	Target Neighborhood Hits	227	Shared Neighborhood Hits	15
SwissProt Accessions	Q80W04, Q6A061	Gene names	Tmcc2, Kiaa0481
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domains protein 2.

ABI1_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.070390 (rank : 139)
Query Neighborhood Hits	90	Target Neighborhood Hits	257	Shared Neighborhood Hits	18
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 92)	NC score	0.074473 (rank : 127)
Query Neighborhood Hits	90	Target Neighborhood Hits	246	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.077086 (rank : 120)
Query Neighborhood Hits	90	Target Neighborhood Hits	350	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 94)	NC score	0.077634 (rank : 118)
Query Neighborhood Hits	90	Target Neighborhood Hits	266	Shared Neighborhood Hits	18
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.068427 (rank : 142)
Query Neighborhood Hits	90	Target Neighborhood Hits	227	Shared Neighborhood Hits	17
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 96)	NC score	0.066103 (rank : 144)
Query Neighborhood Hits	90	Target Neighborhood Hits	227	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABR_HUMAN
θ value	θ > 10 (rank : 97)	NC score	0.213289 (rank : 70)
Query Neighborhood Hits	90	Target Neighborhood Hits	166	Shared Neighborhood Hits	49
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

AHI1_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.060529 (rank : 159)
Query Neighborhood Hits	90	Target Neighborhood Hits	537	Shared Neighborhood Hits	25
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.060413 (rank : 160)
Query Neighborhood Hits	90	Target Neighborhood Hits	496	Shared Neighborhood Hits	22
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ANM2_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.055446 (rank : 173)
Query Neighborhood Hits	90	Target Neighborhood Hits	175	Shared Neighborhood Hits	16
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 101)	NC score	0.052423 (rank : 192)
Query Neighborhood Hits	90	Target Neighborhood Hits	175	Shared Neighborhood Hits	16
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHG6_HUMAN
θ value	θ > 10 (rank : 102)	NC score	0.274843 (rank : 66)
Query Neighborhood Hits	90	Target Neighborhood Hits	376	Shared Neighborhood Hits	49
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	θ > 10 (rank : 103)	NC score	0.256713 (rank : 67)
Query Neighborhood Hits	90	Target Neighborhood Hits	394	Shared Neighborhood Hits	47
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHGA_HUMAN
θ value	θ > 10 (rank : 104)	NC score	0.376525 (rank : 54)
Query Neighborhood Hits	90	Target Neighborhood Hits	187	Shared Neighborhood Hits	55
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 105)	NC score	0.360463 (rank : 55)
Query Neighborhood Hits	90	Target Neighborhood Hits	125	Shared Neighborhood Hits	53
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

BAIP2_HUMAN
θ value	θ > 10 (rank : 106)	NC score	0.052867 (rank : 190)
Query Neighborhood Hits	90	Target Neighborhood Hits	192	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	θ > 10 (rank : 107)	NC score	0.054107 (rank : 184)
Query Neighborhood Hits	90	Target Neighborhood Hits	185	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BCAR1_HUMAN
θ value	θ > 10 (rank : 108)	NC score	0.052198 (rank : 194)
Query Neighborhood Hits	90	Target Neighborhood Hits	554	Shared Neighborhood Hits	19
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	θ > 10 (rank : 109)	NC score	0.054722 (rank : 178)
Query Neighborhood Hits	90	Target Neighborhood Hits	438	Shared Neighborhood Hits	19
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCR_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.222105 (rank : 69)
Query Neighborhood Hits	90	Target Neighborhood Hits	204	Shared Neighborhood Hits	47
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

BI2L1_HUMAN
θ value	θ > 10 (rank : 111)	NC score	0.070891 (rank : 136)
Query Neighborhood Hits	90	Target Neighborhood Hits	156	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 112)	NC score	0.055689 (rank : 172)
Query Neighborhood Hits	90	Target Neighborhood Hits	197	Shared Neighborhood Hits	19
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CASL_HUMAN
θ value	θ > 10 (rank : 113)	NC score	0.054143 (rank : 183)
Query Neighborhood Hits	90	Target Neighborhood Hits	259	Shared Neighborhood Hits	19
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	θ > 10 (rank : 114)	NC score	0.050198 (rank : 201)
Query Neighborhood Hits	90	Target Neighborhood Hits	225	Shared Neighborhood Hits	19
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CD2AP_HUMAN
θ value	θ > 10 (rank : 115)	NC score	0.112368 (rank : 81)
Query Neighborhood Hits	90	Target Neighborhood Hits	315	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 116)	NC score	0.113548 (rank : 79)
Query Neighborhood Hits	90	Target Neighborhood Hits	336	Shared Neighborhood Hits	24
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CRKL_HUMAN
θ value	θ > 10 (rank : 117)	NC score	0.076177 (rank : 121)
Query Neighborhood Hits	90	Target Neighborhood Hits	313	Shared Neighborhood Hits	18
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 118)	NC score	0.074296 (rank : 128)
Query Neighborhood Hits	90	Target Neighborhood Hits	307	Shared Neighborhood Hits	18
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 119)	NC score	0.070762 (rank : 138)
Query Neighborhood Hits	90	Target Neighborhood Hits	308	Shared Neighborhood Hits	19
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 120)	NC score	0.073094 (rank : 131)
Query Neighborhood Hits	90	Target Neighborhood Hits	314	Shared Neighborhood Hits	20
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CT032_HUMAN
θ value	θ > 10 (rank : 121)	NC score	0.054706 (rank : 179)
Query Neighborhood Hits	90	Target Neighborhood Hits	235	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DBNL_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.071626 (rank : 134)
Query Neighborhood Hits	90	Target Neighborhood Hits	244	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 123)	NC score	0.062249 (rank : 152)
Query Neighborhood Hits	90	Target Neighborhood Hits	306	Shared Neighborhood Hits	22
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

EEA1_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.051490 (rank : 196)
Query Neighborhood Hits	90	Target Neighborhood Hits	1796	Shared Neighborhood Hits	43
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

EEA1_MOUSE
θ value	θ > 10 (rank : 125)	NC score	0.054554 (rank : 180)
Query Neighborhood Hits	90	Target Neighborhood Hits	1637	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

EFS_MOUSE
θ value	θ > 10 (rank : 126)	NC score	0.055312 (rank : 174)
Query Neighborhood Hits	90	Target Neighborhood Hits	389	Shared Neighborhood Hits	19
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

EP15R_HUMAN
θ value	θ > 10 (rank : 127)	NC score	0.052546 (rank : 191)
Query Neighborhood Hits	90	Target Neighborhood Hits	1083	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

EP15R_MOUSE
θ value	θ > 10 (rank : 128)	NC score	0.055724 (rank : 171)
Query Neighborhood Hits	90	Target Neighborhood Hits	1135	Shared Neighborhood Hits	22
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

EP15_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.050165 (rank : 202)
Query Neighborhood Hits	90	Target Neighborhood Hits	1021	Shared Neighborhood Hits	23
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP15_MOUSE
θ value	θ > 10 (rank : 130)	NC score	0.050436 (rank : 199)
Query Neighborhood Hits	90	Target Neighborhood Hits	820	Shared Neighborhood Hits	22
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

FARP2_HUMAN
θ value	θ > 10 (rank : 131)	NC score	0.277579 (rank : 64)
Query Neighborhood Hits	90	Target Neighborhood Hits	240	Shared Neighborhood Hits	49
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
θ value	θ > 10 (rank : 132)	NC score	0.314309 (rank : 58)
Query Neighborhood Hits	90	Target Neighborhood Hits	209	Shared Neighborhood Hits	54
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FGD5_MOUSE
θ value	θ > 10 (rank : 133)	NC score	0.289710 (rank : 62)
Query Neighborhood Hits	90	Target Neighborhood Hits	170	Shared Neighborhood Hits	37
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FYV1_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.050795 (rank : 198)
Query Neighborhood Hits	90	Target Neighborhood Hits	217	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

GNRP_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.277328 (rank : 65)
Query Neighborhood Hits	90	Target Neighborhood Hits	239	Shared Neighborhood Hits	47
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 136)	NC score	0.292804 (rank : 61)
Query Neighborhood Hits	90	Target Neighborhood Hits	191	Shared Neighborhood Hits	47
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GRAP2_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.075156 (rank : 122)
Query Neighborhood Hits	90	Target Neighborhood Hits	304	Shared Neighborhood Hits	19
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.075034 (rank : 123)
Query Neighborhood Hits	90	Target Neighborhood Hits	297	Shared Neighborhood Hits	18
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.092751 (rank : 97)
Query Neighborhood Hits	90	Target Neighborhood Hits	307	Shared Neighborhood Hits	19
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.091879 (rank : 101)
Query Neighborhood Hits	90	Target Neighborhood Hits	309	Shared Neighborhood Hits	20
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.084859 (rank : 106)
Query Neighborhood Hits	90	Target Neighborhood Hits	310	Shared Neighborhood Hits	19
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 142)	NC score	0.084814 (rank : 107)
Query Neighborhood Hits	90	Target Neighborhood Hits	312	Shared Neighborhood Hits	19
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

HCLS1_HUMAN
θ value	θ > 10 (rank : 143)	NC score	0.077251 (rank : 119)
Query Neighborhood Hits	90	Target Neighborhood Hits	358	Shared Neighborhood Hits	18
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 144)	NC score	0.079740 (rank : 110)
Query Neighborhood Hits	90	Target Neighborhood Hits	329	Shared Neighborhood Hits	19
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HGS_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.078003 (rank : 116)
Query Neighborhood Hits	90	Target Neighborhood Hits	517	Shared Neighborhood Hits	21
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	θ > 10 (rank : 146)	NC score	0.078337 (rank : 115)
Query Neighborhood Hits	90	Target Neighborhood Hits	589	Shared Neighborhood Hits	21
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

LASP1_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.061314 (rank : 156)
Query Neighborhood Hits	90	Target Neighborhood Hits	293	Shared Neighborhood Hits	18
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	θ > 10 (rank : 148)	NC score	0.059572 (rank : 162)
Query Neighborhood Hits	90	Target Neighborhood Hits	297	Shared Neighborhood Hits	18
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

NCF1_HUMAN
θ value	θ > 10 (rank : 149)	NC score	0.116334 (rank : 78)
Query Neighborhood Hits	90	Target Neighborhood Hits	198	Shared Neighborhood Hits	22
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 150)	NC score	0.109542 (rank : 84)
Query Neighborhood Hits	90	Target Neighborhood Hits	198	Shared Neighborhood Hits	21
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.109323 (rank : 85)
Query Neighborhood Hits	90	Target Neighborhood Hits	229	Shared Neighborhood Hits	21
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.092698 (rank : 98)
Query Neighborhood Hits	90	Target Neighborhood Hits	161	Shared Neighborhood Hits	17
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 153)	NC score	0.091898 (rank : 100)
Query Neighborhood Hits	90	Target Neighborhood Hits	177	Shared Neighborhood Hits	19
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.099550 (rank : 93)
Query Neighborhood Hits	90	Target Neighborhood Hits	312	Shared Neighborhood Hits	22
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.094748 (rank : 95)
Query Neighborhood Hits	90	Target Neighborhood Hits	310	Shared Neighborhood Hits	22
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NEBL_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.061630 (rank : 154)
Query Neighborhood Hits	90	Target Neighborhood Hits	457	Shared Neighborhood Hits	28
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NGEF_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.545022 (rank : 21)
Query Neighborhood Hits	90	Target Neighborhood Hits	166	Shared Neighborhood Hits	58
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 158)	NC score	0.537726 (rank : 25)
Query Neighborhood Hits	90	Target Neighborhood Hits	228	Shared Neighborhood Hits	57
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NOXO1_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.064338 (rank : 149)
Query Neighborhood Hits	90	Target Neighborhood Hits	100	Shared Neighborhood Hits	15
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 160)	NC score	0.066146 (rank : 143)
Query Neighborhood Hits	90	Target Neighborhood Hits	114	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.055259 (rank : 175)
Query Neighborhood Hits	90	Target Neighborhood Hits	288	Shared Neighborhood Hits	19
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 162)	NC score	0.060549 (rank : 158)
Query Neighborhood Hits	90	Target Neighborhood Hits	267	Shared Neighborhood Hits	23
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OSTF1_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.062574 (rank : 151)
Query Neighborhood Hits	90	Target Neighborhood Hits	466	Shared Neighborhood Hits	19
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 164)	NC score	0.061722 (rank : 153)
Query Neighborhood Hits	90	Target Neighborhood Hits	467	Shared Neighborhood Hits	19
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PACN2_HUMAN
θ value	θ > 10 (rank : 165)	NC score	0.053362 (rank : 187)
Query Neighborhood Hits	90	Target Neighborhood Hits	339	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 166)	NC score	0.053988 (rank : 185)
Query Neighborhood Hits	90	Target Neighborhood Hits	382	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.054749 (rank : 177)
Query Neighborhood Hits	90	Target Neighborhood Hits	385	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 168)	NC score	0.054763 (rank : 176)
Query Neighborhood Hits	90	Target Neighborhood Hits	380	Shared Neighborhood Hits	26
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PDZD8_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.050063 (rank : 204)
Query Neighborhood Hits	90	Target Neighborhood Hits	185	Shared Neighborhood Hits	10
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PEX13_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.056299 (rank : 170)
Query Neighborhood Hits	90	Target Neighborhood Hits	128	Shared Neighborhood Hits	16
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 171)	NC score	0.059089 (rank : 163)
Query Neighborhood Hits	90	Target Neighborhood Hits	126	Shared Neighborhood Hits	15
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PKHF1_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.126201 (rank : 75)
Query Neighborhood Hits	90	Target Neighborhood Hits	76	Shared Neighborhood Hits	15
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
θ value	θ > 10 (rank : 173)	NC score	0.124801 (rank : 76)
Query Neighborhood Hits	90	Target Neighborhood Hits	80	Shared Neighborhood Hits	14
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF2_HUMAN
θ value	θ > 10 (rank : 174)	NC score	0.134565 (rank : 73)
Query Neighborhood Hits	90	Target Neighborhood Hits	75	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	θ > 10 (rank : 175)	NC score	0.133918 (rank : 74)
Query Neighborhood Hits	90	Target Neighborhood Hits	77	Shared Neighborhood Hits	15
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHG1_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.459788 (rank : 37)
Query Neighborhood Hits	90	Target Neighborhood Hits	174	Shared Neighborhood Hits	58
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PKHG4_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.252845 (rank : 68)
Query Neighborhood Hits	90	Target Neighborhood Hits	200	Shared Neighborhood Hits	45
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

PLCG1_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.063724 (rank : 150)
Query Neighborhood Hits	90	Target Neighborhood Hits	293	Shared Neighborhood Hits	16
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.065282 (rank : 148)
Query Neighborhood Hits	90	Target Neighborhood Hits	314	Shared Neighborhood Hits	17
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.057383 (rank : 167)
Query Neighborhood Hits	90	Target Neighborhood Hits	280	Shared Neighborhood Hits	14
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP1_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.073896 (rank : 129)
Query Neighborhood Hits	90	Target Neighborhood Hits	389	Shared Neighborhood Hits	26
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 182)	NC score	0.071224 (rank : 135)
Query Neighborhood Hits	90	Target Neighborhood Hits	377	Shared Neighborhood Hits	25
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

RBNS5_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.078871 (rank : 114)
Query Neighborhood Hits	90	Target Neighborhood Hits	242	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	θ > 10 (rank : 184)	NC score	0.074942 (rank : 124)
Query Neighborhood Hits	90	Target Neighborhood Hits	266	Shared Neighborhood Hits	20
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

REPS1_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.054474 (rank : 182)
Query Neighborhood Hits	90	Target Neighborhood Hits	205	Shared Neighborhood Hits	6
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS1_MOUSE
θ value	θ > 10 (rank : 186)	NC score	0.057265 (rank : 168)
Query Neighborhood Hits	90	Target Neighborhood Hits	204	Shared Neighborhood Hits	8
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS2_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.065447 (rank : 145)
Query Neighborhood Hits	90	Target Neighborhood Hits	131	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_MOUSE
θ value	θ > 10 (rank : 188)	NC score	0.065344 (rank : 146)
Query Neighborhood Hits	90	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

RHG04_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.050254 (rank : 200)
Query Neighborhood Hits	90	Target Neighborhood Hits	307	Shared Neighborhood Hits	18
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RHPN1_MOUSE
θ value	θ > 10 (rank : 190)	NC score	0.051642 (rank : 195)
Query Neighborhood Hits	90	Target Neighborhood Hits	154	Shared Neighborhood Hits	4
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

RIMB2_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.053194 (rank : 188)
Query Neighborhood Hits	90	Target Neighborhood Hits	263	Shared Neighborhood Hits	16
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 192)	NC score	0.052282 (rank : 193)
Query Neighborhood Hits	90	Target Neighborhood Hits	246	Shared Neighborhood Hits	15
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RUFY1_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.057624 (rank : 166)
Query Neighborhood Hits	90	Target Neighborhood Hits	848	Shared Neighborhood Hits	32
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

RUFY1_MOUSE
θ value	θ > 10 (rank : 194)	NC score	0.057695 (rank : 165)
Query Neighborhood Hits	90	Target Neighborhood Hits	765	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY2_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.057230 (rank : 169)
Query Neighborhood Hits	90	Target Neighborhood Hits	1208	Shared Neighborhood Hits	33
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

RUFY2_MOUSE
θ value	θ > 10 (rank : 196)	NC score	0.058764 (rank : 164)
Query Neighborhood Hits	90	Target Neighborhood Hits	820	Shared Neighborhood Hits	30
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

SH3G1_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.071960 (rank : 133)
Query Neighborhood Hits	90	Target Neighborhood Hits	307	Shared Neighborhood Hits	22
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 198)	NC score	0.070861 (rank : 137)
Query Neighborhood Hits	90	Target Neighborhood Hits	291	Shared Neighborhood Hits	21
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.070303 (rank : 140)
Query Neighborhood Hits	90	Target Neighborhood Hits	324	Shared Neighborhood Hits	26
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.069969 (rank : 141)
Query Neighborhood Hits	90	Target Neighborhood Hits	319	Shared Neighborhood Hits	24
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.072612 (rank : 132)
Query Neighborhood Hits	90	Target Neighborhood Hits	222	Shared Neighborhood Hits	19
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.074499 (rank : 126)
Query Neighborhood Hits	90	Target Neighborhood Hits	236	Shared Neighborhood Hits	19
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.122175 (rank : 77)
Query Neighborhood Hits	90	Target Neighborhood Hits	341	Shared Neighborhood Hits	24
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 204)	NC score	0.112632 (rank : 80)
Query Neighborhood Hits	90	Target Neighborhood Hits	332	Shared Neighborhood Hits	23
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SHAN1_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.065327 (rank : 147)
Query Neighborhood Hits	90	Target Neighborhood Hits	1041	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHAN2_MOUSE
θ value	θ > 10 (rank : 206)	NC score	0.092291 (rank : 99)
Query Neighborhood Hits	90	Target Neighborhood Hits	446	Shared Neighborhood Hits	23
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SOS1_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.110951 (rank : 83)
Query Neighborhood Hits	90	Target Neighborhood Hits	274	Shared Neighborhood Hits	27
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.104018 (rank : 88)
Query Neighborhood Hits	90	Target Neighborhood Hits	281	Shared Neighborhood Hits	26
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS2_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.111530 (rank : 82)
Query Neighborhood Hits	90	Target Neighborhood Hits	193	Shared Neighborhood Hits	27
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SRBS1_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.103451 (rank : 90)
Query Neighborhood Hits	90	Target Neighborhood Hits	396	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 211)	NC score	0.108031 (rank : 86)
Query Neighborhood Hits	90	Target Neighborhood Hits	409	Shared Neighborhood Hits	25
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.079405 (rank : 113)
Query Neighborhood Hits	90	Target Neighborhood Hits	269	Shared Neighborhood Hits	20
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.077766 (rank : 117)
Query Neighborhood Hits	90	Target Neighborhood Hits	292	Shared Neighborhood Hits	19
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

STAC3_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.084730 (rank : 108)
Query Neighborhood Hits	90	Target Neighborhood Hits	228	Shared Neighborhood Hits	19
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 215)	NC score	0.084977 (rank : 105)
Query Neighborhood Hits	90	Target Neighborhood Hits	232	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.103806 (rank : 89)
Query Neighborhood Hits	90	Target Neighborhood Hits	276	Shared Neighborhood Hits	23
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 217)	NC score	0.100984 (rank : 92)
Query Neighborhood Hits	90	Target Neighborhood Hits	268	Shared Neighborhood Hits	23
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.079473 (rank : 112)
Query Neighborhood Hits	90	Target Neighborhood Hits	271	Shared Neighborhood Hits	19
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 219)	NC score	0.079589 (rank : 111)
Query Neighborhood Hits	90	Target Neighborhood Hits	273	Shared Neighborhood Hits	19
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 220)	NC score	0.073886 (rank : 130)
Query Neighborhood Hits	90	Target Neighborhood Hits	288	Shared Neighborhood Hits	21
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 221)	NC score	0.074845 (rank : 125)
Query Neighborhood Hits	90	Target Neighborhood Hits	285	Shared Neighborhood Hits	21
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

UN13A_HUMAN
θ value	θ > 10 (rank : 222)	NC score	0.054542 (rank : 181)
Query Neighborhood Hits	90	Target Neighborhood Hits	285	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_MOUSE
θ value	θ > 10 (rank : 223)	NC score	0.051093 (rank : 197)
Query Neighborhood Hits	90	Target Neighborhood Hits	210	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

VINEX_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.104719 (rank : 87)
Query Neighborhood Hits	90	Target Neighborhood Hits	270	Shared Neighborhood Hits	23
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 225)	NC score	0.102222 (rank : 91)
Query Neighborhood Hits	90	Target Neighborhood Hits	286	Shared Neighborhood Hits	21
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ZFY16_HUMAN
θ value	θ > 10 (rank : 226)	NC score	0.086057 (rank : 103)
Query Neighborhood Hits	90	Target Neighborhood Hits	125	Shared Neighborhood Hits	12
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY16_MOUSE
θ value	θ > 10 (rank : 227)	NC score	0.088420 (rank : 102)
Query Neighborhood Hits	90	Target Neighborhood Hits	108	Shared Neighborhood Hits	11
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY19_HUMAN
θ value	θ > 10 (rank : 228)	NC score	0.060722 (rank : 157)
Query Neighborhood Hits	90	Target Neighborhood Hits	206	Shared Neighborhood Hits	12
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ZFY19_MOUSE
θ value	θ > 10 (rank : 229)	NC score	0.059723 (rank : 161)
Query Neighborhood Hits	90	Target Neighborhood Hits	143	Shared Neighborhood Hits	14
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

ZFY21_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.082658 (rank : 109)
Query Neighborhood Hits	90	Target Neighborhood Hits	72	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_MOUSE
θ value	θ > 10 (rank : 231)	NC score	0.085441 (rank : 104)
Query Neighborhood Hits	90	Target Neighborhood Hits	72	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY28_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.095498 (rank : 94)
Query Neighborhood Hits	90	Target Neighborhood Hits	152	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV1_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.053760 (rank : 186)
Query Neighborhood Hits	90	Target Neighborhood Hits	166	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
θ value	θ > 10 (rank : 234)	NC score	0.053019 (rank : 189)
Query Neighborhood Hits	90	Target Neighborhood Hits	153	Shared Neighborhood Hits	14
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

ZFYV9_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.093197 (rank : 96)
Query Neighborhood Hits	90	Target Neighborhood Hits	134	Shared Neighborhood Hits	11
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

Hits sorted by NC score

LBC_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	90	Target Neighborhood Hits	90	Shared Neighborhood Hits	90
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHG2_MOUSE
NC score	0.946664 (rank : 2)	θ value	2.79562e-118 (rank : 2)
Query Neighborhood Hits	90	Target Neighborhood Hits	120	Shared Neighborhood Hits	57
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG2_HUMAN
NC score	0.942818 (rank : 3)	θ value	2.29227e-112 (rank : 4)
Query Neighborhood Hits	90	Target Neighborhood Hits	142	Shared Neighborhood Hits	56
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG1_HUMAN
NC score	0.864964 (rank : 4)	θ value	8.87376e-48 (rank : 5)
Query Neighborhood Hits	90	Target Neighborhood Hits	176	Shared Neighborhood Hits	56
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
NC score	0.842877 (rank : 5)	θ value	7.03111e-45 (rank : 6)
Query Neighborhood Hits	90	Target Neighborhood Hits	266	Shared Neighborhood Hits	52
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

RGNEF_MOUSE
NC score	0.802084 (rank : 6)	θ value	7.12574e-114 (rank : 3)
Query Neighborhood Hits	90	Target Neighborhood Hits	641	Shared Neighborhood Hits	67
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ARHGC_MOUSE
NC score	0.788539 (rank : 7)	θ value	3.37985e-39 (rank : 9)
Query Neighborhood Hits	90	Target Neighborhood Hits	344	Shared Neighborhood Hits	63
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_HUMAN
NC score	0.787216 (rank : 8)	θ value	2.11701e-41 (rank : 8)
Query Neighborhood Hits	90	Target Neighborhood Hits	351	Shared Neighborhood Hits	61
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGB_HUMAN
NC score	0.776583 (rank : 9)	θ value	7.27602e-42 (rank : 7)
Query Neighborhood Hits	90	Target Neighborhood Hits	375	Shared Neighborhood Hits	59
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHG3_MOUSE
NC score	0.706650 (rank : 10)	θ value	4.44505e-15 (rank : 12)
Query Neighborhood Hits	90	Target Neighborhood Hits	85	Shared Neighborhood Hits	53
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG3_HUMAN
NC score	0.706413 (rank : 11)	θ value	1.99529e-15 (rank : 11)
Query Neighborhood Hits	90	Target Neighborhood Hits	82	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG8_HUMAN
NC score	0.674359 (rank : 12)	θ value	1.58096e-12 (rank : 16)
Query Neighborhood Hits	90	Target Neighborhood Hits	85	Shared Neighborhood Hits	55
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
NC score	0.664576 (rank : 13)	θ value	8.95645e-16 (rank : 10)
Query Neighborhood Hits	90	Target Neighborhood Hits	79	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGG_HUMAN
NC score	0.629764 (rank : 14)	θ value	8.67504e-11 (rank : 21)
Query Neighborhood Hits	90	Target Neighborhood Hits	129	Shared Neighborhood Hits	57
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
NC score	0.608055 (rank : 15)	θ value	1.06045e-08 (rank : 28)
Query Neighborhood Hits	90	Target Neighborhood Hits	152	Shared Neighborhood Hits	57
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG5_HUMAN
NC score	0.597664 (rank : 16)	θ value	6.21693e-09 (rank : 27)
Query Neighborhood Hits	90	Target Neighborhood Hits	172	Shared Neighborhood Hits	56
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ECT2_MOUSE
NC score	0.593467 (rank : 17)	θ value	3.19293e-05 (rank : 37)
Query Neighborhood Hits	90	Target Neighborhood Hits	98	Shared Neighborhood Hits	59
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_HUMAN
NC score	0.578767 (rank : 18)	θ value	1.43324e-05 (rank : 35)
Query Neighborhood Hits	90	Target Neighborhood Hits	98	Shared Neighborhood Hits	58
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

FGD3_MOUSE
NC score	0.574274 (rank : 19)	θ value	1.47974e-10 (rank : 23)
Query Neighborhood Hits	90	Target Neighborhood Hits	257	Shared Neighborhood Hits	57
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

ARHGF_HUMAN
NC score	0.565028 (rank : 20)	θ value	1.99992e-07 (rank : 31)
Query Neighborhood Hits	90	Target Neighborhood Hits	214	Shared Neighborhood Hits	51
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

NGEF_HUMAN
NC score	0.545022 (rank : 21)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	90	Target Neighborhood Hits	166	Shared Neighborhood Hits	58
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

FGD2_MOUSE
NC score	0.543262 (rank : 22)	θ value	7.34386e-10 (rank : 26)
Query Neighborhood Hits	90	Target Neighborhood Hits	163	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
NC score	0.542542 (rank : 23)	θ value	1.9326e-10 (rank : 24)
Query Neighborhood Hits	90	Target Neighborhood Hits	249	Shared Neighborhood Hits	57
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD4_HUMAN
NC score	0.538370 (rank : 24)	θ value	7.09661e-13 (rank : 14)
Query Neighborhood Hits	90	Target Neighborhood Hits	219	Shared Neighborhood Hits	58
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

NGEF_MOUSE
NC score	0.537726 (rank : 25)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	90	Target Neighborhood Hits	228	Shared Neighborhood Hits	57
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

FGD2_HUMAN
NC score	0.536571 (rank : 26)	θ value	7.34386e-10 (rank : 25)
Query Neighborhood Hits	90	Target Neighborhood Hits	151	Shared Neighborhood Hits	56
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD4_MOUSE
NC score	0.535317 (rank : 27)	θ value	1.58096e-12 (rank : 17)
Query Neighborhood Hits	90	Target Neighborhood Hits	227	Shared Neighborhood Hits	58
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

PREX1_HUMAN
NC score	0.534363 (rank : 28)	θ value	0.00102713 (rank : 47)
Query Neighborhood Hits	90	Target Neighborhood Hits	177	Shared Neighborhood Hits	57
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

FGD1_MOUSE
NC score	0.528508 (rank : 29)	θ value	4.59992e-12 (rank : 20)
Query Neighborhood Hits	90	Target Neighborhood Hits	387	Shared Neighborhood Hits	56
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

TIAM1_MOUSE
NC score	0.524900 (rank : 30)	θ value	4.1701e-05 (rank : 39)
Query Neighborhood Hits	90	Target Neighborhood Hits	205	Shared Neighborhood Hits	56
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

FGD1_HUMAN
NC score	0.523024 (rank : 31)	θ value	1.47974e-10 (rank : 22)
Query Neighborhood Hits	90	Target Neighborhood Hits	367	Shared Neighborhood Hits	58
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

TIAM1_HUMAN
NC score	0.512628 (rank : 32)	θ value	0.000158464 (rank : 42)
Query Neighborhood Hits	90	Target Neighborhood Hits	225	Shared Neighborhood Hits	56
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG9_HUMAN
NC score	0.506256 (rank : 33)	θ value	1.43324e-05 (rank : 33)
Query Neighborhood Hits	90	Target Neighborhood Hits	235	Shared Neighborhood Hits	56
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.504579 (rank : 34)	θ value	1.43324e-05 (rank : 34)
Query Neighborhood Hits	90	Target Neighborhood Hits	234	Shared Neighborhood Hits	56
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG4_MOUSE
NC score	0.498306 (rank : 35)	θ value	0.0193708 (rank : 54)
Query Neighborhood Hits	90	Target Neighborhood Hits	185	Shared Neighborhood Hits	56
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_HUMAN
NC score	0.481941 (rank : 36)	θ value	0.00228821 (rank : 48)
Query Neighborhood Hits	90	Target Neighborhood Hits	242	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PKHG1_HUMAN
NC score	0.459788 (rank : 37)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	90	Target Neighborhood Hits	174	Shared Neighborhood Hits	58
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ITSN2_HUMAN
NC score	0.450122 (rank : 38)	θ value	7.09661e-13 (rank : 15)
Query Neighborhood Hits	90	Target Neighborhood Hits	1173	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

MCF2_HUMAN
NC score	0.446588 (rank : 39)	θ value	0.0252991 (rank : 55)
Query Neighborhood Hits	90	Target Neighborhood Hits	166	Shared Neighborhood Hits	58
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

DNMBP_MOUSE
NC score	0.434113 (rank : 40)	θ value	2.36244e-08 (rank : 29)
Query Neighborhood Hits	90	Target Neighborhood Hits	435	Shared Neighborhood Hits	59
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_HUMAN
NC score	0.427433 (rank : 41)	θ value	4.0297e-08 (rank : 30)
Query Neighborhood Hits	90	Target Neighborhood Hits	413	Shared Neighborhood Hits	60
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ITSN2_MOUSE
NC score	0.425218 (rank : 42)	θ value	3.52202e-12 (rank : 19)
Query Neighborhood Hits	90	Target Neighborhood Hits	1371	Shared Neighborhood Hits	72
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

VAV2_HUMAN
NC score	0.423260 (rank : 43)	θ value	7.1131e-05 (rank : 40)
Query Neighborhood Hits	90	Target Neighborhood Hits	453	Shared Neighborhood Hits	59
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
NC score	0.420009 (rank : 44)	θ value	0.000121331 (rank : 41)
Query Neighborhood Hits	90	Target Neighborhood Hits	456	Shared Neighborhood Hits	59
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV_MOUSE
NC score	0.418389 (rank : 45)	θ value	3.19293e-05 (rank : 38)
Query Neighborhood Hits	90	Target Neighborhood Hits	430	Shared Neighborhood Hits	57
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

MCF2L_MOUSE
NC score	0.417837 (rank : 46)	θ value	0.000461057 (rank : 45)
Query Neighborhood Hits	90	Target Neighborhood Hits	255	Shared Neighborhood Hits	63
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

ITSN1_HUMAN
NC score	0.412180 (rank : 47)	θ value	1.09485e-13 (rank : 13)
Query Neighborhood Hits	90	Target Neighborhood Hits	1757	Shared Neighborhood Hits	73
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.409249 (rank : 48)	θ value	1.58096e-12 (rank : 18)
Query Neighborhood Hits	90	Target Neighborhood Hits	1669	Shared Neighborhood Hits	71
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

FGD6_MOUSE
NC score	0.406785 (rank : 49)	θ value	0.000786445 (rank : 46)
Query Neighborhood Hits	90	Target Neighborhood Hits	282	Shared Neighborhood Hits	55
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD6_HUMAN
NC score	0.404113 (rank : 50)	θ value	0.00665767 (rank : 51)
Query Neighborhood Hits	90	Target Neighborhood Hits	237	Shared Neighborhood Hits	52
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

VAV_HUMAN
NC score	0.400833 (rank : 51)	θ value	0.00035302 (rank : 44)
Query Neighborhood Hits	90	Target Neighborhood Hits	452	Shared Neighborhood Hits	58
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV3_MOUSE
NC score	0.388232 (rank : 52)	θ value	4.92598e-06 (rank : 32)
Query Neighborhood Hits	90	Target Neighborhood Hits	404	Shared Neighborhood Hits	55
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV3_HUMAN
NC score	0.385359 (rank : 53)	θ value	1.87187e-05 (rank : 36)
Query Neighborhood Hits	90	Target Neighborhood Hits	398	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ARHGA_HUMAN
NC score	0.376525 (rank : 54)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	90	Target Neighborhood Hits	187	Shared Neighborhood Hits	55
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
NC score	0.360463 (rank : 55)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	90	Target Neighborhood Hits	125	Shared Neighborhood Hits	53
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

HAPIP_HUMAN
NC score	0.344382 (rank : 56)	θ value	0.0330416 (rank : 56)
Query Neighborhood Hits	90	Target Neighborhood Hits	350	Shared Neighborhood Hits	64
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ARHG7_HUMAN
NC score	0.333349 (rank : 57)	θ value	0.00020696 (rank : 43)
Query Neighborhood Hits	90	Target Neighborhood Hits	347	Shared Neighborhood Hits	53
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

FARP2_MOUSE
NC score	0.314309 (rank : 58)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	90	Target Neighborhood Hits	209	Shared Neighborhood Hits	54
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FGD5_HUMAN
NC score	0.310361 (rank : 59)	θ value	0.0563607 (rank : 58)
Query Neighborhood Hits	90	Target Neighborhood Hits	235	Shared Neighborhood Hits	39
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

ARHG7_MOUSE
NC score	0.306603 (rank : 60)	θ value	0.0563607 (rank : 57)
Query Neighborhood Hits	90	Target Neighborhood Hits	396	Shared Neighborhood Hits	54
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

GNRP_MOUSE
NC score	0.292804 (rank : 61)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	90	Target Neighborhood Hits	191	Shared Neighborhood Hits	47
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

FGD5_MOUSE
NC score	0.289710 (rank : 62)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	90	Target Neighborhood Hits	170	Shared Neighborhood Hits	37
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FARP1_HUMAN
NC score	0.289501 (rank : 63)	θ value	0.00228821 (rank : 49)
Query Neighborhood Hits	90	Target Neighborhood Hits	241	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FARP2_HUMAN
NC score	0.277579 (rank : 64)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	90	Target Neighborhood Hits	240	Shared Neighborhood Hits	49
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

GNRP_HUMAN
NC score	0.277328 (rank : 65)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	90	Target Neighborhood Hits	239	Shared Neighborhood Hits	47
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

ARHG6_HUMAN
NC score	0.274843 (rank : 66)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	90	Target Neighborhood Hits	376	Shared Neighborhood Hits	49
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
NC score	0.256713 (rank : 67)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	90	Target Neighborhood Hits	394	Shared Neighborhood Hits	47
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

PKHG4_HUMAN
NC score	0.252845 (rank : 68)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	90	Target Neighborhood Hits	200	Shared Neighborhood Hits	45
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

BCR_HUMAN
NC score	0.222105 (rank : 69)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	90	Target Neighborhood Hits	204	Shared Neighborhood Hits	47
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ABR_HUMAN
NC score	0.213289 (rank : 70)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	90	Target Neighborhood Hits	166	Shared Neighborhood Hits	49
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

DUET_HUMAN
NC score	0.152631 (rank : 71)	θ value	0.00869519 (rank : 53)
Query Neighborhood Hits	90	Target Neighborhood Hits	1220	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

TRIO_HUMAN
NC score	0.147005 (rank : 72)	θ value	0.00228821 (rank : 50)
Query Neighborhood Hits	90	Target Neighborhood Hits	1580	Shared Neighborhood Hits	70
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

PKHF2_HUMAN
NC score	0.134565 (rank : 73)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	90	Target Neighborhood Hits	75	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
NC score	0.133918 (rank : 74)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	90	Target Neighborhood Hits	77	Shared Neighborhood Hits	15
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHF1_HUMAN
NC score	0.126201 (rank : 75)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	90	Target Neighborhood Hits	76	Shared Neighborhood Hits	15
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
NC score	0.124801 (rank : 76)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	90	Target Neighborhood Hits	80	Shared Neighborhood Hits	14
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

SH3K1_HUMAN
NC score	0.122175 (rank : 77)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	90	Target Neighborhood Hits	341	Shared Neighborhood Hits	24
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

NCF1_HUMAN
NC score	0.116334 (rank : 78)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	90	Target Neighborhood Hits	198	Shared Neighborhood Hits	22
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

CD2AP_MOUSE
NC score	0.113548 (rank : 79)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	90	Target Neighborhood Hits	336	Shared Neighborhood Hits	24
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

SH3K1_MOUSE
NC score	0.112632 (rank : 80)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	90	Target Neighborhood Hits	332	Shared Neighborhood Hits	23
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

CD2AP_HUMAN
NC score	0.112368 (rank : 81)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	90	Target Neighborhood Hits	315	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SOS2_HUMAN
NC score	0.111530 (rank : 82)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	90	Target Neighborhood Hits	193	Shared Neighborhood Hits	27
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SOS1_HUMAN
NC score	0.110951 (rank : 83)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	90	Target Neighborhood Hits	274	Shared Neighborhood Hits	27
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

NCF1_MOUSE
NC score	0.109542 (rank : 84)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	90	Target Neighborhood Hits	198	Shared Neighborhood Hits	21
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
NC score	0.109323 (rank : 85)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	90	Target Neighborhood Hits	229	Shared Neighborhood Hits	21
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

SRBS1_MOUSE
NC score	0.108031 (rank : 86)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	90	Target Neighborhood Hits	409	Shared Neighborhood Hits	25
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

VINEX_HUMAN
NC score	0.104719 (rank : 87)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	90	Target Neighborhood Hits	270	Shared Neighborhood Hits	23
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

SOS1_MOUSE
NC score	0.104018 (rank : 88)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	90	Target Neighborhood Hits	281	Shared Neighborhood Hits	26
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

STAC_HUMAN
NC score	0.103806 (rank : 89)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	90	Target Neighborhood Hits	276	Shared Neighborhood Hits	23
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SRBS1_HUMAN
NC score	0.103451 (rank : 90)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	90	Target Neighborhood Hits	396	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

VINEX_MOUSE
NC score	0.102222 (rank : 91)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	90	Target Neighborhood Hits	286	Shared Neighborhood Hits	21
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

STAC_MOUSE
NC score	0.100984 (rank : 92)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	90	Target Neighborhood Hits	268	Shared Neighborhood Hits	23
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

NCK1_HUMAN
NC score	0.099550 (rank : 93)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	90	Target Neighborhood Hits	312	Shared Neighborhood Hits	22
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

ZFY28_HUMAN
NC score	0.095498 (rank : 94)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	90	Target Neighborhood Hits	152	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

NCK2_HUMAN
NC score	0.094748 (rank : 95)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	90	Target Neighborhood Hits	310	Shared Neighborhood Hits	22
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

ZFYV9_HUMAN
NC score	0.093197 (rank : 96)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	90	Target Neighborhood Hits	134	Shared Neighborhood Hits	11
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

GRAP_HUMAN
NC score	0.092751 (rank : 97)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	90	Target Neighborhood Hits	307	Shared Neighborhood Hits	19
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

NCF4_HUMAN
NC score	0.092698 (rank : 98)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	90	Target Neighborhood Hits	161	Shared Neighborhood Hits	17
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

SHAN2_MOUSE
NC score	0.092291 (rank : 99)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	90	Target Neighborhood Hits	446	Shared Neighborhood Hits	23
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

NCF4_MOUSE
NC score	0.091898 (rank : 100)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	90	Target Neighborhood Hits	177	Shared Neighborhood Hits	19
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

GRAP_MOUSE
NC score	0.091879 (rank : 101)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	90	Target Neighborhood Hits	309	Shared Neighborhood Hits	20
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

ZFY16_MOUSE
NC score	0.088420 (rank : 102)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	90	Target Neighborhood Hits	108	Shared Neighborhood Hits	11
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY16_HUMAN
NC score	0.086057 (rank : 103)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	90	Target Neighborhood Hits	125	Shared Neighborhood Hits	12
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY21_MOUSE
NC score	0.085441 (rank : 104)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	90	Target Neighborhood Hits	72	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

STAC3_MOUSE
NC score	0.084977 (rank : 105)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	90	Target Neighborhood Hits	232	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

GRB2_HUMAN
NC score	0.084859 (rank : 106)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	90	Target Neighborhood Hits	310	Shared Neighborhood Hits	19
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.084814 (rank : 107)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	90	Target Neighborhood Hits	312	Shared Neighborhood Hits	19
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

STAC3_HUMAN
NC score	0.084730 (rank : 108)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	90	Target Neighborhood Hits	228	Shared Neighborhood Hits	19
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ZFY21_HUMAN
NC score	0.082658 (rank : 109)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	90	Target Neighborhood Hits	72	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

HCLS1_MOUSE
NC score	0.079740 (rank : 110)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	90	Target Neighborhood Hits	329	Shared Neighborhood Hits	19
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

STAM1_MOUSE
NC score	0.079589 (rank : 111)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	90	Target Neighborhood Hits	273	Shared Neighborhood Hits	19
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_HUMAN
NC score	0.079473 (rank : 112)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	90	Target Neighborhood Hits	271	Shared Neighborhood Hits	19
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

SRC8_HUMAN
NC score	0.079405 (rank : 113)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	90	Target Neighborhood Hits	269	Shared Neighborhood Hits	20
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

RBNS5_HUMAN
NC score	0.078871 (rank : 114)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	90	Target Neighborhood Hits	242	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

HGS_MOUSE
NC score	0.078337 (rank : 115)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	90	Target Neighborhood Hits	589	Shared Neighborhood Hits	21
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

HGS_HUMAN
NC score	0.078003 (rank : 116)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	90	Target Neighborhood Hits	517	Shared Neighborhood Hits	21
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

SRC8_MOUSE
NC score	0.077766 (rank : 117)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	90	Target Neighborhood Hits	292	Shared Neighborhood Hits	19
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

ABI2_MOUSE
NC score	0.077634 (rank : 118)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	90	Target Neighborhood Hits	266	Shared Neighborhood Hits	18
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

HCLS1_HUMAN
NC score	0.077251 (rank : 119)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	90	Target Neighborhood Hits	358	Shared Neighborhood Hits	18
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

ABI2_HUMAN
NC score	0.077086 (rank : 120)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	90	Target Neighborhood Hits	350	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

CRKL_HUMAN
NC score	0.076177 (rank : 121)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	90	Target Neighborhood Hits	313	Shared Neighborhood Hits	18
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

GRAP2_HUMAN
NC score	0.075156 (rank : 122)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	90	Target Neighborhood Hits	304	Shared Neighborhood Hits	19
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
NC score	0.075034 (rank : 123)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	90	Target Neighborhood Hits	297	Shared Neighborhood Hits	18
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

RBNS5_MOUSE
NC score	0.074942 (rank : 124)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	90	Target Neighborhood Hits	266	Shared Neighborhood Hits	20
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

STAM2_MOUSE
NC score	0.074845 (rank : 125)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	90	Target Neighborhood Hits	285	Shared Neighborhood Hits	21
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

SH3G3_MOUSE
NC score	0.074499 (rank : 126)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	90	Target Neighborhood Hits	236	Shared Neighborhood Hits	19
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

ABI1_MOUSE
NC score	0.074473 (rank : 127)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	90	Target Neighborhood Hits	246	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

CRKL_MOUSE
NC score	0.074296 (rank : 128)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	90	Target Neighborhood Hits	307	Shared Neighborhood Hits	18
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

PPIP1_HUMAN
NC score	0.073896 (rank : 129)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	90	Target Neighborhood Hits	389	Shared Neighborhood Hits	26
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

STAM2_HUMAN
NC score	0.073886 (rank : 130)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	90	Target Neighborhood Hits	288	Shared Neighborhood Hits	21
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

CRK_MOUSE
NC score	0.073094 (rank : 131)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	90	Target Neighborhood Hits	314	Shared Neighborhood Hits	20
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SH3G3_HUMAN
NC score	0.072612 (rank : 132)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	90	Target Neighborhood Hits	222	Shared Neighborhood Hits	19
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G1_HUMAN
NC score	0.071960 (rank : 133)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	90	Target Neighborhood Hits	307	Shared Neighborhood Hits	22
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

DBNL_HUMAN
NC score	0.071626 (rank : 134)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	90	Target Neighborhood Hits	244	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

PPIP1_MOUSE
NC score	0.071224 (rank : 135)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	90	Target Neighborhood Hits	377	Shared Neighborhood Hits	25
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

BI2L1_HUMAN
NC score	0.070891 (rank : 136)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	90	Target Neighborhood Hits	156	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

SH3G1_MOUSE
NC score	0.070861 (rank : 137)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	90	Target Neighborhood Hits	291	Shared Neighborhood Hits	21
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

CRK_HUMAN
NC score	0.070762 (rank : 138)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	90	Target Neighborhood Hits	308	Shared Neighborhood Hits	19
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

ABI1_HUMAN
NC score	0.070390 (rank : 139)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	90	Target Neighborhood Hits	257	Shared Neighborhood Hits	18
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

SH3G2_HUMAN
NC score	0.070303 (rank : 140)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	90	Target Neighborhood Hits	324	Shared Neighborhood Hits	26
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
NC score	0.069969 (rank : 141)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	90	Target Neighborhood Hits	319	Shared Neighborhood Hits	24
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

ABI3_HUMAN
NC score	0.068427 (rank : 142)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	90	Target Neighborhood Hits	227	Shared Neighborhood Hits	17
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

NOXO1_MOUSE
NC score	0.066146 (rank : 143)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	90	Target Neighborhood Hits	114	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

ABI3_MOUSE
NC score	0.066103 (rank : 144)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	90	Target Neighborhood Hits	227	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

REPS2_HUMAN
NC score	0.065447 (rank : 145)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	90	Target Neighborhood Hits	131	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_MOUSE
NC score	0.065344 (rank : 146)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	90	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

SHAN1_HUMAN
NC score	0.065327 (rank : 147)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	90	Target Neighborhood Hits	1041	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

PLCG1_MOUSE
NC score	0.065282 (rank : 148)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	90	Target Neighborhood Hits	314	Shared Neighborhood Hits	17
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

NOXO1_HUMAN
NC score	0.064338 (rank : 149)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	90	Target Neighborhood Hits	100	Shared Neighborhood Hits	15
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

PLCG1_HUMAN
NC score	0.063724 (rank : 150)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	90	Target Neighborhood Hits	293	Shared Neighborhood Hits	16
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

OSTF1_HUMAN
NC score	0.062574 (rank : 151)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	90	Target Neighborhood Hits	466	Shared Neighborhood Hits	19
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

DBNL_MOUSE
NC score	0.062249 (rank : 152)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	90	Target Neighborhood Hits	306	Shared Neighborhood Hits	22
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

OSTF1_MOUSE
NC score	0.061722 (rank : 153)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	90	Target Neighborhood Hits	467	Shared Neighborhood Hits	19
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

NEBL_HUMAN
NC score	0.061630 (rank : 154)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	90	Target Neighborhood Hits	457	Shared Neighborhood Hits	28
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

CU013_HUMAN
NC score	0.061447 (rank : 155)	θ value	0.00869519 (rank : 52)
Query Neighborhood Hits	90	Target Neighborhood Hits	405	Shared Neighborhood Hits	23
SwissProt Accessions	O95447	Gene names	C21orf13
Domain Architecture
Description	Protein C21orf13.

LASP1_HUMAN
NC score	0.061314 (rank : 156)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	90	Target Neighborhood Hits	293	Shared Neighborhood Hits	18
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

ZFY19_HUMAN
NC score	0.060722 (rank : 157)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	90	Target Neighborhood Hits	206	Shared Neighborhood Hits	12
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

NPHP1_MOUSE
NC score	0.060549 (rank : 158)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	90	Target Neighborhood Hits	267	Shared Neighborhood Hits	23
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

AHI1_HUMAN
NC score	0.060529 (rank : 159)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	90	Target Neighborhood Hits	537	Shared Neighborhood Hits	25
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
NC score	0.060413 (rank : 160)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	90	Target Neighborhood Hits	496	Shared Neighborhood Hits	22
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ZFY19_MOUSE
NC score	0.059723 (rank : 161)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	90	Target Neighborhood Hits	143	Shared Neighborhood Hits	14
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

LASP1_MOUSE
NC score	0.059572 (rank : 162)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	90	Target Neighborhood Hits	297	Shared Neighborhood Hits	18
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

PEX13_MOUSE
NC score	0.059089 (rank : 163)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	90	Target Neighborhood Hits	126	Shared Neighborhood Hits	15
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

RUFY2_MOUSE
NC score	0.058764 (rank : 164)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	90	Target Neighborhood Hits	820	Shared Neighborhood Hits	30
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

RUFY1_MOUSE
NC score	0.057695 (rank : 165)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	90	Target Neighborhood Hits	765	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY1_HUMAN
NC score	0.057624 (rank : 166)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	90	Target Neighborhood Hits	848	Shared Neighborhood Hits	32
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

PLCG2_HUMAN
NC score	0.057383 (rank : 167)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	90	Target Neighborhood Hits	280	Shared Neighborhood Hits	14
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

REPS1_MOUSE
NC score	0.057265 (rank : 168)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	90	Target Neighborhood Hits	204	Shared Neighborhood Hits	8
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

RUFY2_HUMAN
NC score	0.057230 (rank : 169)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	90	Target Neighborhood Hits	1208	Shared Neighborhood Hits	33
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

PEX13_HUMAN
NC score	0.056299 (rank : 170)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	90	Target Neighborhood Hits	128	Shared Neighborhood Hits	16
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

EP15R_MOUSE
NC score	0.055724 (rank : 171)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	90	Target Neighborhood Hits	1135	Shared Neighborhood Hits	22
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

BI2L1_MOUSE
NC score	0.055689 (rank : 172)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	90	Target Neighborhood Hits	197	Shared Neighborhood Hits	19
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

ANM2_HUMAN
NC score	0.055446 (rank : 173)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	90	Target Neighborhood Hits	175	Shared Neighborhood Hits	16
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

EFS_MOUSE
NC score	0.055312 (rank : 174)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	90	Target Neighborhood Hits	389	Shared Neighborhood Hits	19
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

NPHP1_HUMAN
NC score	0.055259 (rank : 175)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	90	Target Neighborhood Hits	288	Shared Neighborhood Hits	19
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

PACN3_MOUSE
NC score	0.054763 (rank : 176)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	90	Target Neighborhood Hits	380	Shared Neighborhood Hits	26
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PACN3_HUMAN
NC score	0.054749 (rank : 177)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	90	Target Neighborhood Hits	385	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

BCAR1_MOUSE
NC score	0.054722 (rank : 178)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	90	Target Neighborhood Hits	438	Shared Neighborhood Hits	19
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CT032_HUMAN
NC score	0.054706 (rank : 179)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	90	Target Neighborhood Hits	235	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

EEA1_MOUSE
NC score	0.054554 (rank : 180)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	90	Target Neighborhood Hits	1637	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

UN13A_HUMAN
NC score	0.054542 (rank : 181)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	90	Target Neighborhood Hits	285	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

REPS1_HUMAN
NC score	0.054474 (rank : 182)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	90	Target Neighborhood Hits	205	Shared Neighborhood Hits	6
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

CASL_HUMAN
NC score	0.054143 (rank : 183)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	90	Target Neighborhood Hits	259	Shared Neighborhood Hits	19
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

BAIP2_MOUSE
NC score	0.054107 (rank : 184)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	90	Target Neighborhood Hits	185	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

PACN2_MOUSE
NC score	0.053988 (rank : 185)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	90	Target Neighborhood Hits	382	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

ZFYV1_HUMAN
NC score	0.053760 (rank : 186)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	90	Target Neighborhood Hits	166	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

PACN2_HUMAN
NC score	0.053362 (rank : 187)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	90	Target Neighborhood Hits	339	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

RIMB2_HUMAN
NC score	0.053194 (rank : 188)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	90	Target Neighborhood Hits	263	Shared Neighborhood Hits	16
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

ZFYV1_MOUSE
NC score	0.053019 (rank : 189)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	90	Target Neighborhood Hits	153	Shared Neighborhood Hits	14
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

BAIP2_HUMAN
NC score	0.052867 (rank : 190)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	90	Target Neighborhood Hits	192	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

EP15R_HUMAN
NC score	0.052546 (rank : 191)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	90	Target Neighborhood Hits	1083	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

ANM2_MOUSE
NC score	0.052423 (rank : 192)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	90	Target Neighborhood Hits	175	Shared Neighborhood Hits	16
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

RIMB2_MOUSE
NC score	0.052282 (rank : 193)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	90	Target Neighborhood Hits	246	Shared Neighborhood Hits	15
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

BCAR1_HUMAN
NC score	0.052198 (rank : 194)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	90	Target Neighborhood Hits	554	Shared Neighborhood Hits	19
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

RHPN1_MOUSE
NC score	0.051642 (rank : 195)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	90	Target Neighborhood Hits	154	Shared Neighborhood Hits	4
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

EEA1_HUMAN
NC score	0.051490 (rank : 196)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	90	Target Neighborhood Hits	1796	Shared Neighborhood Hits	43
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

UN13B_MOUSE
NC score	0.051093 (rank : 197)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	90	Target Neighborhood Hits	210	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

FYV1_HUMAN
NC score	0.050795 (rank : 198)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	90	Target Neighborhood Hits	217	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

EP15_MOUSE
NC score	0.050436 (rank : 199)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	90	Target Neighborhood Hits	820	Shared Neighborhood Hits	22
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

RHG04_HUMAN
NC score	0.050254 (rank : 200)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	90	Target Neighborhood Hits	307	Shared Neighborhood Hits	18
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

CASL_MOUSE
NC score	0.050198 (rank : 201)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	90	Target Neighborhood Hits	225	Shared Neighborhood Hits	19
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

EP15_HUMAN
NC score	0.050165 (rank : 202)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	90	Target Neighborhood Hits	1021	Shared Neighborhood Hits	23
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

IFT81_MOUSE
NC score	0.050135 (rank : 203)	θ value	0.62314 (rank : 63)
Query Neighborhood Hits	90	Target Neighborhood Hits	959	Shared Neighborhood Hits	26
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

PDZD8_HUMAN
NC score	0.050063 (rank : 204)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	90	Target Neighborhood Hits	185	Shared Neighborhood Hits	10
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

RB6I2_MOUSE
NC score	0.037561 (rank : 205)	θ value	4.03905 (rank : 75)
Query Neighborhood Hits	90	Target Neighborhood Hits	1433	Shared Neighborhood Hits	29
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

RB6I2_HUMAN
NC score	0.035776 (rank : 206)	θ value	4.03905 (rank : 74)
Query Neighborhood Hits	90	Target Neighborhood Hits	1584	Shared Neighborhood Hits	32
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

LRC45_MOUSE
NC score	0.035194 (rank : 207)	θ value	4.03905 (rank : 71)
Query Neighborhood Hits	90	Target Neighborhood Hits	959	Shared Neighborhood Hits	23
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

IFT81_HUMAN
NC score	0.033283 (rank : 208)	θ value	4.03905 (rank : 70)
Query Neighborhood Hits	90	Target Neighborhood Hits	893	Shared Neighborhood Hits	24
SwissProt Accessions	Q8WYA0, Q8NB51, Q9BSV2, Q9UNY8	Gene names	IFT81, CDV1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

ERC2_MOUSE
NC score	0.032809 (rank : 209)	θ value	6.88961 (rank : 78)
Query Neighborhood Hits	90	Target Neighborhood Hits	1166	Shared Neighborhood Hits	28
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

ERC2_HUMAN
NC score	0.031886 (rank : 210)	θ value	6.88961 (rank : 77)
Query Neighborhood Hits	90	Target Neighborhood Hits	1156	Shared Neighborhood Hits	27
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

GOGA4_HUMAN
NC score	0.028991 (rank : 211)	θ value	8.99809 (rank : 85)
Query Neighborhood Hits	90	Target Neighborhood Hits	2034	Shared Neighborhood Hits	36
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

PEPL_HUMAN
NC score	0.028417 (rank : 212)	θ value	1.81305 (rank : 66)
Query Neighborhood Hits	90	Target Neighborhood Hits	1141	Shared Neighborhood Hits	26
SwissProt Accessions	O60437, O60314, O60454	Gene names	PPL, KIAA0568
Domain Architecture
Description	Periplakin (195 kDa cornified envelope precursor protein) (190 kDa paraneoplastic pemphigus antigen).

EXOC4_MOUSE
NC score	0.026328 (rank : 213)	θ value	6.88961 (rank : 79)
Query Neighborhood Hits	90	Target Neighborhood Hits	86	Shared Neighborhood Hits	7
SwissProt Accessions	O35382	Gene names	Exoc4, Sec8, Sec8l1
Domain Architecture
Description	Exocyst complex component 4 (Exocyst complex component Sec8).

EXOC4_HUMAN
NC score	0.025504 (rank : 214)	θ value	8.99809 (rank : 83)
Query Neighborhood Hits	90	Target Neighborhood Hits	72	Shared Neighborhood Hits	7
SwissProt Accessions	Q96A65, Q9C0G4, Q9H9K0, Q9P102	Gene names	EXOC4, KIAA1699, SEC8, SEC8L1
Domain Architecture
Description	Exocyst complex component 4 (Exocyst complex component Sec8).

CENPE_HUMAN
NC score	0.025416 (rank : 215)	θ value	3.0926 (rank : 68)
Query Neighborhood Hits	90	Target Neighborhood Hits	2060	Shared Neighborhood Hits	40
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

C8AP2_MOUSE
NC score	0.024018 (rank : 216)	θ value	0.62314 (rank : 61)
Query Neighborhood Hits	90	Target Neighborhood Hits	405	Shared Neighborhood Hits	10
SwissProt Accessions	Q9WUF3, Q9CSW2	Gene names	Casp8ap2, Flash
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

MACF1_HUMAN
NC score	0.022914 (rank : 217)	θ value	2.36792 (rank : 67)
Query Neighborhood Hits	90	Target Neighborhood Hits	1341	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

CTRO_MOUSE
NC score	0.022586 (rank : 218)	θ value	0.125558 (rank : 59)
Query Neighborhood Hits	90	Target Neighborhood Hits	2344	Shared Neighborhood Hits	36
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

CTRO_HUMAN
NC score	0.018913 (rank : 219)	θ value	0.62314 (rank : 62)
Query Neighborhood Hits	90	Target Neighborhood Hits	2092	Shared Neighborhood Hits	34
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

CHSTA_HUMAN
NC score	0.018638 (rank : 220)	θ value	1.81305 (rank : 64)
Query Neighborhood Hits	90	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	O43529	Gene names	CHST10
Domain Architecture	No domain graphic available
Description	Carbohydrate sulfotransferase 10 (EC 2.8.2.-) (HNK-1 sulfotransferase) (HNK1ST) (HNK-1ST) (huHNK-1ST).

MRCKA_HUMAN
NC score	0.018454 (rank : 221)	θ value	4.03905 (rank : 72)
Query Neighborhood Hits	90	Target Neighborhood Hits	1999	Shared Neighborhood Hits	37
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

DEN2C_MOUSE
NC score	0.017928 (rank : 222)	θ value	0.279714 (rank : 60)
Query Neighborhood Hits	90	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	Q6P9P8, Q3T9X2, Q3UV30, Q80V46	Gene names	Dennd2c
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2C.

CHSTA_MOUSE
NC score	0.016455 (rank : 223)	θ value	4.03905 (rank : 69)
Query Neighborhood Hits	90	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PGK7, Q8BKU3, Q8BL08, Q8R2Y5, Q91Y40	Gene names	Chst10
Domain Architecture	No domain graphic available
Description	Carbohydrate sulfotransferase 10 (EC 2.8.2.-) (HNK-1 sulfotransferase) (HNK1ST) (HNK-1ST).

DPOLM_MOUSE
NC score	0.014940 (rank : 224)	θ value	1.81305 (rank : 65)
Query Neighborhood Hits	90	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JIW4, Q9JJW9	Gene names	Polm
Domain Architecture
Description	DNA polymerase mu (EC 2.7.7.7) (Pol Mu).

TMCC2_MOUSE
NC score	0.013997 (rank : 225)	θ value	8.99809 (rank : 90)
Query Neighborhood Hits	90	Target Neighborhood Hits	227	Shared Neighborhood Hits	15
SwissProt Accessions	Q80W04, Q6A061	Gene names	Tmcc2, Kiaa0481
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domains protein 2.

NOG2_HUMAN
NC score	0.013497 (rank : 226)	θ value	4.03905 (rank : 73)
Query Neighborhood Hits	90	Target Neighborhood Hits	117	Shared Neighborhood Hits	8
SwissProt Accessions	Q13823, Q9BWN7	Gene names	GNL2, NGP1
Domain Architecture
Description	Nucleolar GTP-binding protein 2 (Autoantigen NGP-1).

TBCD4_HUMAN
NC score	0.013210 (rank : 227)	θ value	8.99809 (rank : 88)
Query Neighborhood Hits	90	Target Neighborhood Hits	357	Shared Neighborhood Hits	14
SwissProt Accessions	O60343, Q5W0B9	Gene names	TBC1D4, KIAA0603
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160).

TMCC2_HUMAN
NC score	0.013112 (rank : 228)	θ value	8.99809 (rank : 89)
Query Neighborhood Hits	90	Target Neighborhood Hits	227	Shared Neighborhood Hits	14
SwissProt Accessions	O75069, Q6ZN09	Gene names	TMCC2, KIAA0481
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domains protein 2 (Cerebral protein 11).

QKI_HUMAN
NC score	0.012969 (rank : 229)	θ value	6.88961 (rank : 80)
Query Neighborhood Hits	90	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	Q96PU8, Q2I375, Q5MJQ1, Q969L9, Q96EJ3, Q96KA3, Q96PU6, Q96PU7, Q9P0X6, Q9P0X7, Q9P0X8, Q9P0X9, Q9P0Y0, Q9P0Y1	Gene names	QKI, HKQ
Domain Architecture	No domain graphic available
Description	Quaking protein (Hqk).

QKI_MOUSE
NC score	0.012969 (rank : 230)	θ value	6.88961 (rank : 81)
Query Neighborhood Hits	90	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QYS9, O88972, Q61110, Q78ZE4, Q78ZE5, Q8K4X9, Q8K4Y0, Q9CW34, Q9QUH4, Q9R2A8, Q9Z246	Gene names	Qki, Qk, Qk1, Qka1
Domain Architecture	No domain graphic available
Description	Quaking protein (qkI).

IQGA2_HUMAN
NC score	0.009300 (rank : 231)	θ value	5.27518 (rank : 76)
Query Neighborhood Hits	90	Target Neighborhood Hits	200	Shared Neighborhood Hits	9
SwissProt Accessions	Q13576	Gene names	IQGAP2
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP2.

FBX43_MOUSE
NC score	0.008238 (rank : 232)	θ value	8.99809 (rank : 84)
Query Neighborhood Hits	90	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CDI2, Q4G0C8, Q8R0R1	Gene names	Fbxo43, Emi2
Domain Architecture	No domain graphic available
Description	F-box only protein 43 (Endogenous meiotic inhibitor 2).

SFRIP_HUMAN
NC score	0.007273 (rank : 233)	θ value	8.99809 (rank : 86)
Query Neighborhood Hits	90	Target Neighborhood Hits	530	Shared Neighborhood Hits	8
SwissProt Accessions	Q99590, Q8IW59	Gene names	SFRS2IP, CASP11, SIP1
Domain Architecture	No domain graphic available
Description	SFRS2-interacting protein (Splicing factor, arginine/serine-rich 2- interacting protein) (SC35-interacting protein 1) (CTD-associated SR protein 11) (Splicing regulatory protein 129) (SRrp129) (NY-REN-40 antigen).

TRI25_HUMAN
NC score	0.003288 (rank : 234)	θ value	6.88961 (rank : 82)
Query Neighborhood Hits	90	Target Neighborhood Hits	472	Shared Neighborhood Hits	8
SwissProt Accessions	Q14258	Gene names	TRIM25, EFP, RNF147, ZNF147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp) (RING finger protein 147).

STCH_MOUSE
NC score	0.003036 (rank : 235)	θ value	8.99809 (rank : 87)
Query Neighborhood Hits	90	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BM72, Q3TII6, Q9D1X5	Gene names	Stch
Domain Architecture	No domain graphic available
Description	Stress 70 protein chaperone microsome-associated 60 kDa protein precursor (Microsomal stress 70 protein ATPase core).