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Network neighborhood for query Sequence : ARHGB_HUMAN

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ARHGB_HUMAN
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ARHGB_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	375	Target Neighborhood Hits	375	Shared Neighborhood Hits	375
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_MOUSE
θ value	1.09934e-114 (rank : 2)	NC score	0.920612 (rank : 3)
Query Neighborhood Hits	375	Target Neighborhood Hits	344	Shared Neighborhood Hits	212
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_HUMAN
θ value	4.1775e-114 (rank : 3)	NC score	0.922384 (rank : 2)
Query Neighborhood Hits	375	Target Neighborhood Hits	351	Shared Neighborhood Hits	208
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHG1_MOUSE
θ value	1.06975e-93 (rank : 4)	NC score	0.813101 (rank : 5)
Query Neighborhood Hits	375	Target Neighborhood Hits	266	Shared Neighborhood Hits	78
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG1_HUMAN
θ value	5.14231e-88 (rank : 5)	NC score	0.835875 (rank : 4)
Query Neighborhood Hits	375	Target Neighborhood Hits	176	Shared Neighborhood Hits	74
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

LBC_HUMAN
θ value	7.27602e-42 (rank : 6)	NC score	0.776583 (rank : 6)
Query Neighborhood Hits	375	Target Neighborhood Hits	90	Shared Neighborhood Hits	59
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHG2_MOUSE
θ value	1.62093e-41 (rank : 7)	NC score	0.769764 (rank : 7)
Query Neighborhood Hits	375	Target Neighborhood Hits	120	Shared Neighborhood Hits	63
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG2_HUMAN
θ value	4.71619e-41 (rank : 8)	NC score	0.754746 (rank : 8)
Query Neighborhood Hits	375	Target Neighborhood Hits	142	Shared Neighborhood Hits	62
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

RGNEF_MOUSE
θ value	3.05695e-40 (rank : 9)	NC score	0.664674 (rank : 11)
Query Neighborhood Hits	375	Target Neighborhood Hits	641	Shared Neighborhood Hits	94
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ITSN1_HUMAN
θ value	1.02001e-27 (rank : 10)	NC score	0.438360 (rank : 48)
Query Neighborhood Hits	375	Target Neighborhood Hits	1757	Shared Neighborhood Hits	143
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	1.02001e-27 (rank : 11)	NC score	0.437815 (rank : 50)
Query Neighborhood Hits	375	Target Neighborhood Hits	1669	Shared Neighborhood Hits	143
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
θ value	8.63488e-27 (rank : 12)	NC score	0.476786 (rank : 39)
Query Neighborhood Hits	375	Target Neighborhood Hits	1173	Shared Neighborhood Hits	131
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	7.30988e-26 (rank : 13)	NC score	0.452679 (rank : 45)
Query Neighborhood Hits	375	Target Neighborhood Hits	1371	Shared Neighborhood Hits	135
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ARHG3_MOUSE
θ value	6.62687e-19 (rank : 14)	NC score	0.673774 (rank : 9)
Query Neighborhood Hits	375	Target Neighborhood Hits	85	Shared Neighborhood Hits	65
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG3_HUMAN
θ value	1.24977e-17 (rank : 15)	NC score	0.673394 (rank : 10)
Query Neighborhood Hits	375	Target Neighborhood Hits	82	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ECT2_MOUSE
θ value	3.07829e-16 (rank : 16)	NC score	0.648536 (rank : 15)
Query Neighborhood Hits	375	Target Neighborhood Hits	98	Shared Neighborhood Hits	69
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHGG_MOUSE
θ value	5.25075e-16 (rank : 17)	NC score	0.652265 (rank : 14)
Query Neighborhood Hits	375	Target Neighborhood Hits	152	Shared Neighborhood Hits	68
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ECT2_HUMAN
θ value	5.25075e-16 (rank : 18)	NC score	0.633899 (rank : 19)
Query Neighborhood Hits	375	Target Neighborhood Hits	98	Shared Neighborhood Hits	68
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHG5_HUMAN
θ value	5.8054e-15 (rank : 19)	NC score	0.641647 (rank : 17)
Query Neighborhood Hits	375	Target Neighborhood Hits	172	Shared Neighborhood Hits	72
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

NGEF_HUMAN
θ value	7.58209e-15 (rank : 20)	NC score	0.634696 (rank : 18)
Query Neighborhood Hits	375	Target Neighborhood Hits	166	Shared Neighborhood Hits	69
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	2.88119e-14 (rank : 21)	NC score	0.624691 (rank : 20)
Query Neighborhood Hits	375	Target Neighborhood Hits	228	Shared Neighborhood Hits	77
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHGG_HUMAN
θ value	1.86753e-13 (rank : 22)	NC score	0.659218 (rank : 12)
Query Neighborhood Hits	375	Target Neighborhood Hits	129	Shared Neighborhood Hits	70
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG8_MOUSE
θ value	2.43908e-13 (rank : 23)	NC score	0.647378 (rank : 16)
Query Neighborhood Hits	375	Target Neighborhood Hits	79	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGF_HUMAN
θ value	4.16044e-13 (rank : 24)	NC score	0.616684 (rank : 21)
Query Neighborhood Hits	375	Target Neighborhood Hits	214	Shared Neighborhood Hits	80
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHG8_HUMAN
θ value	9.26847e-13 (rank : 25)	NC score	0.656711 (rank : 13)
Query Neighborhood Hits	375	Target Neighborhood Hits	85	Shared Neighborhood Hits	66
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

VAV3_HUMAN
θ value	9.26847e-13 (rank : 26)	NC score	0.436675 (rank : 51)
Query Neighborhood Hits	375	Target Neighborhood Hits	398	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ARHG9_HUMAN
θ value	2.0648e-12 (rank : 27)	NC score	0.553191 (rank : 27)
Query Neighborhood Hits	375	Target Neighborhood Hits	235	Shared Neighborhood Hits	79
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

VAV3_MOUSE
θ value	2.69671e-12 (rank : 28)	NC score	0.438854 (rank : 47)
Query Neighborhood Hits	375	Target Neighborhood Hits	404	Shared Neighborhood Hits	72
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ARHG9_MOUSE
θ value	3.52202e-12 (rank : 29)	NC score	0.552674 (rank : 28)
Query Neighborhood Hits	375	Target Neighborhood Hits	234	Shared Neighborhood Hits	79
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

FGD4_MOUSE
θ value	4.59992e-12 (rank : 30)	NC score	0.539173 (rank : 30)
Query Neighborhood Hits	375	Target Neighborhood Hits	227	Shared Neighborhood Hits	76
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

VAV_MOUSE
θ value	1.74796e-11 (rank : 31)	NC score	0.462402 (rank : 43)
Query Neighborhood Hits	375	Target Neighborhood Hits	430	Shared Neighborhood Hits	75
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

PREX1_HUMAN
θ value	2.98157e-11 (rank : 32)	NC score	0.593042 (rank : 22)
Query Neighborhood Hits	375	Target Neighborhood Hits	177	Shared Neighborhood Hits	105
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ARHG4_MOUSE
θ value	3.89403e-11 (rank : 33)	NC score	0.560119 (rank : 26)
Query Neighborhood Hits	375	Target Neighborhood Hits	185	Shared Neighborhood Hits	77
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

FGD3_HUMAN
θ value	3.89403e-11 (rank : 34)	NC score	0.537140 (rank : 32)
Query Neighborhood Hits	375	Target Neighborhood Hits	249	Shared Neighborhood Hits	72
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

VAV2_HUMAN
θ value	3.89403e-11 (rank : 35)	NC score	0.463033 (rank : 42)
Query Neighborhood Hits	375	Target Neighborhood Hits	453	Shared Neighborhood Hits	75
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

FGD3_MOUSE
θ value	1.133e-10 (rank : 36)	NC score	0.561079 (rank : 25)
Query Neighborhood Hits	375	Target Neighborhood Hits	257	Shared Neighborhood Hits	72
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD4_HUMAN
θ value	1.47974e-10 (rank : 37)	NC score	0.540524 (rank : 29)
Query Neighborhood Hits	375	Target Neighborhood Hits	219	Shared Neighborhood Hits	78
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD1_HUMAN
θ value	1.9326e-10 (rank : 38)	NC score	0.514281 (rank : 37)
Query Neighborhood Hits	375	Target Neighborhood Hits	367	Shared Neighborhood Hits	85
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

VAV2_MOUSE
θ value	1.9326e-10 (rank : 39)	NC score	0.460403 (rank : 44)
Query Neighborhood Hits	375	Target Neighborhood Hits	456	Shared Neighborhood Hits	77
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

FGD1_MOUSE
θ value	2.52405e-10 (rank : 40)	NC score	0.518468 (rank : 36)
Query Neighborhood Hits	375	Target Neighborhood Hits	387	Shared Neighborhood Hits	87
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

RHPN1_MOUSE
θ value	4.30538e-10 (rank : 41)	NC score	0.323650 (rank : 98)
Query Neighborhood Hits	375	Target Neighborhood Hits	154	Shared Neighborhood Hits	128
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

VAV_HUMAN
θ value	7.34386e-10 (rank : 42)	NC score	0.446548 (rank : 46)
Query Neighborhood Hits	375	Target Neighborhood Hits	452	Shared Neighborhood Hits	75
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

TIAM1_HUMAN
θ value	9.59137e-10 (rank : 43)	NC score	0.587515 (rank : 23)
Query Neighborhood Hits	375	Target Neighborhood Hits	225	Shared Neighborhood Hits	128
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	9.59137e-10 (rank : 44)	NC score	0.580528 (rank : 24)
Query Neighborhood Hits	375	Target Neighborhood Hits	205	Shared Neighborhood Hits	106
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

PKHG1_HUMAN
θ value	1.63604e-09 (rank : 45)	NC score	0.531266 (rank : 34)
Query Neighborhood Hits	375	Target Neighborhood Hits	174	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

FGD2_MOUSE
θ value	2.13673e-09 (rank : 46)	NC score	0.532583 (rank : 33)
Query Neighborhood Hits	375	Target Neighborhood Hits	163	Shared Neighborhood Hits	69
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

ARHG4_HUMAN
θ value	2.79066e-09 (rank : 47)	NC score	0.537172 (rank : 31)
Query Neighborhood Hits	375	Target Neighborhood Hits	242	Shared Neighborhood Hits	79
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

FARP2_MOUSE
θ value	3.64472e-09 (rank : 48)	NC score	0.363509 (rank : 69)
Query Neighborhood Hits	375	Target Neighborhood Hits	209	Shared Neighborhood Hits	73
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_HUMAN
θ value	1.06045e-08 (rank : 49)	NC score	0.333041 (rank : 85)
Query Neighborhood Hits	375	Target Neighborhood Hits	240	Shared Neighborhood Hits	71
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ARHGA_MOUSE
θ value	1.80886e-08 (rank : 50)	NC score	0.468000 (rank : 41)
Query Neighborhood Hits	375	Target Neighborhood Hits	125	Shared Neighborhood Hits	66
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

FARP1_HUMAN
θ value	4.0297e-08 (rank : 51)	NC score	0.327041 (rank : 92)
Query Neighborhood Hits	375	Target Neighborhood Hits	241	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FGD2_HUMAN
θ value	4.0297e-08 (rank : 52)	NC score	0.525594 (rank : 35)
Query Neighborhood Hits	375	Target Neighborhood Hits	151	Shared Neighborhood Hits	71
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

ARHGA_HUMAN
θ value	6.87365e-08 (rank : 53)	NC score	0.493901 (rank : 38)
Query Neighborhood Hits	375	Target Neighborhood Hits	187	Shared Neighborhood Hits	75
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

PDZD1_MOUSE
θ value	8.97725e-08 (rank : 54)	NC score	0.406238 (rank : 56)
Query Neighborhood Hits	375	Target Neighborhood Hits	191	Shared Neighborhood Hits	150
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

RHPN1_HUMAN
θ value	2.61198e-07 (rank : 55)	NC score	0.300447 (rank : 109)
Query Neighborhood Hits	375	Target Neighborhood Hits	158	Shared Neighborhood Hits	123
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

MCF2_HUMAN
θ value	4.45536e-07 (rank : 56)	NC score	0.468477 (rank : 40)
Query Neighborhood Hits	375	Target Neighborhood Hits	166	Shared Neighborhood Hits	81
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

NHERF_HUMAN
θ value	1.29631e-06 (rank : 57)	NC score	0.385723 (rank : 59)
Query Neighborhood Hits	375	Target Neighborhood Hits	190	Shared Neighborhood Hits	154
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

PDZD1_HUMAN
θ value	1.29631e-06 (rank : 58)	NC score	0.391421 (rank : 57)
Query Neighborhood Hits	375	Target Neighborhood Hits	190	Shared Neighborhood Hits	151
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

GNRP_MOUSE
θ value	1.69304e-06 (rank : 59)	NC score	0.380003 (rank : 62)
Query Neighborhood Hits	375	Target Neighborhood Hits	191	Shared Neighborhood Hits	65
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

MAGI2_HUMAN
θ value	1.69304e-06 (rank : 60)	NC score	0.330204 (rank : 87)
Query Neighborhood Hits	375	Target Neighborhood Hits	373	Shared Neighborhood Hits	162
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MAGI2_MOUSE
θ value	1.69304e-06 (rank : 61)	NC score	0.327364 (rank : 90)
Query Neighborhood Hits	375	Target Neighborhood Hits	370	Shared Neighborhood Hits	160
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

GNRP_HUMAN
θ value	2.21117e-06 (rank : 62)	NC score	0.352634 (rank : 76)
Query Neighborhood Hits	375	Target Neighborhood Hits	239	Shared Neighborhood Hits	64
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

WHRN_MOUSE
θ value	2.21117e-06 (rank : 63)	NC score	0.376299 (rank : 65)
Query Neighborhood Hits	375	Target Neighborhood Hits	412	Shared Neighborhood Hits	180
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

PDZD3_MOUSE
θ value	6.43352e-06 (rank : 64)	NC score	0.372878 (rank : 66)
Query Neighborhood Hits	375	Target Neighborhood Hits	171	Shared Neighborhood Hits	149
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

LNX2_HUMAN
θ value	8.40245e-06 (rank : 65)	NC score	0.298240 (rank : 111)
Query Neighborhood Hits	375	Target Neighborhood Hits	389	Shared Neighborhood Hits	150
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

LNX2_MOUSE
θ value	8.40245e-06 (rank : 66)	NC score	0.300245 (rank : 110)
Query Neighborhood Hits	375	Target Neighborhood Hits	407	Shared Neighborhood Hits	151
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

NHERF_MOUSE
θ value	8.40245e-06 (rank : 67)	NC score	0.390051 (rank : 58)
Query Neighborhood Hits	375	Target Neighborhood Hits	195	Shared Neighborhood Hits	151
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

MAGI1_HUMAN
θ value	1.09739e-05 (rank : 68)	NC score	0.340713 (rank : 83)
Query Neighborhood Hits	375	Target Neighborhood Hits	388	Shared Neighborhood Hits	173
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI1_MOUSE
θ value	1.09739e-05 (rank : 69)	NC score	0.338315 (rank : 84)
Query Neighborhood Hits	375	Target Neighborhood Hits	403	Shared Neighborhood Hits	173
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

LAP4_HUMAN
θ value	1.43324e-05 (rank : 70)	NC score	0.233156 (rank : 154)
Query Neighborhood Hits	375	Target Neighborhood Hits	608	Shared Neighborhood Hits	175
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

PDZD3_HUMAN
θ value	1.43324e-05 (rank : 71)	NC score	0.378293 (rank : 63)
Query Neighborhood Hits	375	Target Neighborhood Hits	180	Shared Neighborhood Hits	148
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

SHAN1_HUMAN
θ value	1.87187e-05 (rank : 72)	NC score	0.210022 (rank : 169)
Query Neighborhood Hits	375	Target Neighborhood Hits	1041	Shared Neighborhood Hits	186
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

DUET_HUMAN
θ value	2.44474e-05 (rank : 73)	NC score	0.168396 (rank : 180)
Query Neighborhood Hits	375	Target Neighborhood Hits	1220	Shared Neighborhood Hits	100
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

GOPC_HUMAN
θ value	2.44474e-05 (rank : 74)	NC score	0.327210 (rank : 91)
Query Neighborhood Hits	375	Target Neighborhood Hits	377	Shared Neighborhood Hits	161
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

GOPC_MOUSE
θ value	2.44474e-05 (rank : 75)	NC score	0.329910 (rank : 88)
Query Neighborhood Hits	375	Target Neighborhood Hits	323	Shared Neighborhood Hits	157
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

GRIP1_HUMAN
θ value	2.44474e-05 (rank : 76)	NC score	0.324640 (rank : 96)
Query Neighborhood Hits	375	Target Neighborhood Hits	231	Shared Neighborhood Hits	164
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

GRIP1_MOUSE
θ value	2.44474e-05 (rank : 77)	NC score	0.322406 (rank : 100)
Query Neighborhood Hits	375	Target Neighborhood Hits	241	Shared Neighborhood Hits	164
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

WHRN_HUMAN
θ value	2.44474e-05 (rank : 78)	NC score	0.372791 (rank : 67)
Query Neighborhood Hits	375	Target Neighborhood Hits	325	Shared Neighborhood Hits	175
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

FGD6_MOUSE
θ value	3.19293e-05 (rank : 79)	NC score	0.438212 (rank : 49)
Query Neighborhood Hits	375	Target Neighborhood Hits	282	Shared Neighborhood Hits	75
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

SHAN2_MOUSE
θ value	3.19293e-05 (rank : 80)	NC score	0.302165 (rank : 108)
Query Neighborhood Hits	375	Target Neighborhood Hits	446	Shared Neighborhood Hits	143
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

MAST4_HUMAN
θ value	4.1701e-05 (rank : 81)	NC score	0.066713 (rank : 342)
Query Neighborhood Hits	375	Target Neighborhood Hits	1804	Shared Neighborhood Hits	168
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

NHRF2_HUMAN
θ value	4.1701e-05 (rank : 82)	NC score	0.385387 (rank : 60)
Query Neighborhood Hits	375	Target Neighborhood Hits	197	Shared Neighborhood Hits	161
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

PARD3_HUMAN
θ value	4.1701e-05 (rank : 83)	NC score	0.322828 (rank : 99)
Query Neighborhood Hits	375	Target Neighborhood Hits	312	Shared Neighborhood Hits	151
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

RGS12_HUMAN
θ value	4.1701e-05 (rank : 84)	NC score	0.206174 (rank : 171)
Query Neighborhood Hits	375	Target Neighborhood Hits	333	Shared Neighborhood Hits	144
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

PARD3_MOUSE
θ value	5.44631e-05 (rank : 85)	NC score	0.321621 (rank : 102)
Query Neighborhood Hits	375	Target Neighborhood Hits	290	Shared Neighborhood Hits	150
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

MAST2_HUMAN
θ value	7.1131e-05 (rank : 86)	NC score	0.065831 (rank : 345)
Query Neighborhood Hits	375	Target Neighborhood Hits	1189	Shared Neighborhood Hits	139
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

PDZD7_HUMAN
θ value	7.1131e-05 (rank : 87)	NC score	0.380225 (rank : 61)
Query Neighborhood Hits	375	Target Neighborhood Hits	181	Shared Neighborhood Hits	151
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

SHAN2_HUMAN
θ value	7.1131e-05 (rank : 88)	NC score	0.271353 (rank : 129)
Query Neighborhood Hits	375	Target Neighborhood Hits	346	Shared Neighborhood Hits	127
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

USH1C_MOUSE
θ value	7.1131e-05 (rank : 89)	NC score	0.359603 (rank : 70)
Query Neighborhood Hits	375	Target Neighborhood Hits	557	Shared Neighborhood Hits	192
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

NHRF2_MOUSE
θ value	9.29e-05 (rank : 90)	NC score	0.372265 (rank : 68)
Query Neighborhood Hits	375	Target Neighborhood Hits	194	Shared Neighborhood Hits	159
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

FGD5_HUMAN
θ value	0.000121331 (rank : 91)	NC score	0.320765 (rank : 103)
Query Neighborhood Hits	375	Target Neighborhood Hits	235	Shared Neighborhood Hits	52
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD6_HUMAN
θ value	0.000121331 (rank : 92)	NC score	0.434510 (rank : 52)
Query Neighborhood Hits	375	Target Neighborhood Hits	237	Shared Neighborhood Hits	68
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

ZO2_HUMAN
θ value	0.000121331 (rank : 93)	NC score	0.266801 (rank : 131)
Query Neighborhood Hits	375	Target Neighborhood Hits	289	Shared Neighborhood Hits	146
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

MAST1_HUMAN
θ value	0.000158464 (rank : 94)	NC score	0.066129 (rank : 344)
Query Neighborhood Hits	375	Target Neighborhood Hits	1146	Shared Neighborhood Hits	144
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST1_MOUSE
θ value	0.000158464 (rank : 95)	NC score	0.065810 (rank : 346)
Query Neighborhood Hits	375	Target Neighborhood Hits	1123	Shared Neighborhood Hits	136
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

RPGF6_HUMAN
θ value	0.000158464 (rank : 96)	NC score	0.248433 (rank : 144)
Query Neighborhood Hits	375	Target Neighborhood Hits	266	Shared Neighborhood Hits	150
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

INADL_MOUSE
θ value	0.00020696 (rank : 97)	NC score	0.332494 (rank : 86)
Query Neighborhood Hits	375	Target Neighborhood Hits	290	Shared Neighborhood Hits	160
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

MAST2_MOUSE
θ value	0.00020696 (rank : 98)	NC score	0.064217 (rank : 353)
Query Neighborhood Hits	375	Target Neighborhood Hits	1110	Shared Neighborhood Hits	139
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST3_HUMAN
θ value	0.00020696 (rank : 99)	NC score	0.063949 (rank : 355)
Query Neighborhood Hits	375	Target Neighborhood Hits	1128	Shared Neighborhood Hits	142
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

DNMBP_HUMAN
θ value	0.000270298 (rank : 100)	NC score	0.409299 (rank : 55)
Query Neighborhood Hits	375	Target Neighborhood Hits	413	Shared Neighborhood Hits	86
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

LIN7A_HUMAN
θ value	0.000270298 (rank : 101)	NC score	0.356269 (rank : 73)
Query Neighborhood Hits	375	Target Neighborhood Hits	193	Shared Neighborhood Hits	158
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7A_MOUSE
θ value	0.000270298 (rank : 102)	NC score	0.356629 (rank : 72)
Query Neighborhood Hits	375	Target Neighborhood Hits	193	Shared Neighborhood Hits	158
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

LIN7B_HUMAN
θ value	0.000270298 (rank : 103)	NC score	0.354984 (rank : 74)
Query Neighborhood Hits	375	Target Neighborhood Hits	200	Shared Neighborhood Hits	156
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

PAR3L_HUMAN
θ value	0.000270298 (rank : 104)	NC score	0.324019 (rank : 97)
Query Neighborhood Hits	375	Target Neighborhood Hits	297	Shared Neighborhood Hits	140
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

ZO2_MOUSE
θ value	0.000270298 (rank : 105)	NC score	0.261304 (rank : 134)
Query Neighborhood Hits	375	Target Neighborhood Hits	296	Shared Neighborhood Hits	138
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

GRIP2_HUMAN
θ value	0.00035302 (rank : 106)	NC score	0.325356 (rank : 93)
Query Neighborhood Hits	375	Target Neighborhood Hits	256	Shared Neighborhood Hits	162
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

LIN7B_MOUSE
θ value	0.00035302 (rank : 107)	NC score	0.353863 (rank : 75)
Query Neighborhood Hits	375	Target Neighborhood Hits	200	Shared Neighborhood Hits	156
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

LIN7C_HUMAN
θ value	0.00035302 (rank : 108)	NC score	0.351208 (rank : 79)
Query Neighborhood Hits	375	Target Neighborhood Hits	198	Shared Neighborhood Hits	157
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
θ value	0.00035302 (rank : 109)	NC score	0.351208 (rank : 80)
Query Neighborhood Hits	375	Target Neighborhood Hits	198	Shared Neighborhood Hits	157
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

NPBL_MOUSE
θ value	0.00035302 (rank : 110)	NC score	0.062204 (rank : 365)
Query Neighborhood Hits	375	Target Neighborhood Hits	1041	Shared Neighborhood Hits	67
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

SNTB2_MOUSE
θ value	0.00035302 (rank : 111)	NC score	0.280804 (rank : 122)
Query Neighborhood Hits	375	Target Neighborhood Hits	181	Shared Neighborhood Hits	137
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

PDZD2_HUMAN
θ value	0.000461057 (rank : 112)	NC score	0.306681 (rank : 107)
Query Neighborhood Hits	375	Target Neighborhood Hits	772	Shared Neighborhood Hits	187
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

RGS3_MOUSE
θ value	0.000461057 (rank : 113)	NC score	0.104032 (rank : 264)
Query Neighborhood Hits	375	Target Neighborhood Hits	1621	Shared Neighborhood Hits	148
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

DNMBP_MOUSE
θ value	0.000602161 (rank : 114)	NC score	0.421547 (rank : 54)
Query Neighborhood Hits	375	Target Neighborhood Hits	435	Shared Neighborhood Hits	92
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

GRIN1_MOUSE
θ value	0.000602161 (rank : 115)	NC score	0.061446 (rank : 370)
Query Neighborhood Hits	375	Target Neighborhood Hits	337	Shared Neighborhood Hits	26
SwissProt Accessions	Q3UNH4, Q6PGF9, Q9QZY2	Gene names	Gprin1
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

LNX1_MOUSE
θ value	0.000602161 (rank : 116)	NC score	0.292741 (rank : 113)
Query Neighborhood Hits	375	Target Neighborhood Hits	377	Shared Neighborhood Hits	147
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

SNTB2_HUMAN
θ value	0.000602161 (rank : 117)	NC score	0.278763 (rank : 125)
Query Neighborhood Hits	375	Target Neighborhood Hits	180	Shared Neighborhood Hits	136
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

USH1C_HUMAN
θ value	0.000602161 (rank : 118)	NC score	0.376316 (rank : 64)
Query Neighborhood Hits	375	Target Neighborhood Hits	327	Shared Neighborhood Hits	170
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

SYJ2B_HUMAN
θ value	0.000786445 (rank : 119)	NC score	0.357215 (rank : 71)
Query Neighborhood Hits	375	Target Neighborhood Hits	162	Shared Neighborhood Hits	137
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

ZO3_HUMAN
θ value	0.00102713 (rank : 120)	NC score	0.275722 (rank : 127)
Query Neighborhood Hits	375	Target Neighborhood Hits	219	Shared Neighborhood Hits	153
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

PTN13_HUMAN
θ value	0.00134147 (rank : 121)	NC score	0.204577 (rank : 172)
Query Neighborhood Hits	375	Target Neighborhood Hits	471	Shared Neighborhood Hits	167
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

RGS3_HUMAN
θ value	0.00134147 (rank : 122)	NC score	0.106258 (rank : 260)
Query Neighborhood Hits	375	Target Neighborhood Hits	1375	Shared Neighborhood Hits	130
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

PDZ11_MOUSE
θ value	0.00175202 (rank : 123)	NC score	0.351458 (rank : 78)
Query Neighborhood Hits	375	Target Neighborhood Hits	154	Shared Neighborhood Hits	133
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZ11_HUMAN
θ value	0.00228821 (rank : 124)	NC score	0.351765 (rank : 77)
Query Neighborhood Hits	375	Target Neighborhood Hits	160	Shared Neighborhood Hits	140
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

DLG2_HUMAN
θ value	0.00298849 (rank : 125)	NC score	0.287093 (rank : 117)
Query Neighborhood Hits	375	Target Neighborhood Hits	279	Shared Neighborhood Hits	155
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG4_HUMAN
θ value	0.00298849 (rank : 126)	NC score	0.285044 (rank : 120)
Query Neighborhood Hits	375	Target Neighborhood Hits	286	Shared Neighborhood Hits	154
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_MOUSE
θ value	0.00298849 (rank : 127)	NC score	0.285106 (rank : 119)
Query Neighborhood Hits	375	Target Neighborhood Hits	282	Shared Neighborhood Hits	155
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

PTN13_MOUSE
θ value	0.00298849 (rank : 128)	NC score	0.199648 (rank : 175)
Query Neighborhood Hits	375	Target Neighborhood Hits	426	Shared Neighborhood Hits	161
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

TRIO_HUMAN
θ value	0.00298849 (rank : 129)	NC score	0.156885 (rank : 189)
Query Neighborhood Hits	375	Target Neighborhood Hits	1580	Shared Neighborhood Hits	126
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

DLG2_MOUSE
θ value	0.00390308 (rank : 130)	NC score	0.284602 (rank : 121)
Query Neighborhood Hits	375	Target Neighborhood Hits	271	Shared Neighborhood Hits	154
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG3_MOUSE
θ value	0.00390308 (rank : 131)	NC score	0.287976 (rank : 114)
Query Neighborhood Hits	375	Target Neighborhood Hits	274	Shared Neighborhood Hits	155
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

BCR_HUMAN
θ value	0.00509761 (rank : 132)	NC score	0.270887 (rank : 130)
Query Neighborhood Hits	375	Target Neighborhood Hits	204	Shared Neighborhood Hits	64
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

LAP4_MOUSE
θ value	0.00509761 (rank : 133)	NC score	0.221620 (rank : 156)
Query Neighborhood Hits	375	Target Neighborhood Hits	590	Shared Neighborhood Hits	173
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

LNX1_HUMAN
θ value	0.00509761 (rank : 134)	NC score	0.287823 (rank : 115)
Query Neighborhood Hits	375	Target Neighborhood Hits	379	Shared Neighborhood Hits	139
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

PZRN3_MOUSE
θ value	0.00509761 (rank : 135)	NC score	0.247154 (rank : 146)
Query Neighborhood Hits	375	Target Neighborhood Hits	447	Shared Neighborhood Hits	137
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

MCF2L_MOUSE
θ value	0.00665767 (rank : 136)	NC score	0.427978 (rank : 53)
Query Neighborhood Hits	375	Target Neighborhood Hits	255	Shared Neighborhood Hits	82
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MPDZ_MOUSE
θ value	0.00665767 (rank : 137)	NC score	0.324747 (rank : 95)
Query Neighborhood Hits	375	Target Neighborhood Hits	298	Shared Neighborhood Hits	163
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

RPGF2_HUMAN
θ value	0.00665767 (rank : 138)	NC score	0.220985 (rank : 157)
Query Neighborhood Hits	375	Target Neighborhood Hits	242	Shared Neighborhood Hits	141
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

ZO1_HUMAN
θ value	0.00665767 (rank : 139)	NC score	0.252386 (rank : 142)
Query Neighborhood Hits	375	Target Neighborhood Hits	474	Shared Neighborhood Hits	159
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

DLG3_HUMAN
θ value	0.00869519 (rank : 140)	NC score	0.285569 (rank : 118)
Query Neighborhood Hits	375	Target Neighborhood Hits	269	Shared Neighborhood Hits	155
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

INADL_HUMAN
θ value	0.00869519 (rank : 141)	NC score	0.325183 (rank : 94)
Query Neighborhood Hits	375	Target Neighborhood Hits	260	Shared Neighborhood Hits	154
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

MPDZ_HUMAN
θ value	0.00869519 (rank : 142)	NC score	0.322319 (rank : 101)
Query Neighborhood Hits	375	Target Neighborhood Hits	261	Shared Neighborhood Hits	164
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

ZO1_MOUSE
θ value	0.00869519 (rank : 143)	NC score	0.259522 (rank : 136)
Query Neighborhood Hits	375	Target Neighborhood Hits	453	Shared Neighborhood Hits	165
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

HTRA3_HUMAN
θ value	0.0148317 (rank : 144)	NC score	0.091372 (rank : 282)
Query Neighborhood Hits	375	Target Neighborhood Hits	152	Shared Neighborhood Hits	60
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

K1849_MOUSE
θ value	0.0148317 (rank : 145)	NC score	0.215275 (rank : 162)
Query Neighborhood Hits	375	Target Neighborhood Hits	335	Shared Neighborhood Hits	139
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

LDB3_MOUSE
θ value	0.0148317 (rank : 146)	NC score	0.138032 (rank : 213)
Query Neighborhood Hits	375	Target Neighborhood Hits	510	Shared Neighborhood Hits	118
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

LIMK1_MOUSE
θ value	0.0148317 (rank : 147)	NC score	0.025026 (rank : 488)
Query Neighborhood Hits	375	Target Neighborhood Hits	1008	Shared Neighborhood Hits	85
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

RHPN2_MOUSE
θ value	0.0148317 (rank : 148)	NC score	0.137151 (rank : 217)
Query Neighborhood Hits	375	Target Neighborhood Hits	60	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BWR8, Q9DBN2	Gene names	Rhpn2
Domain Architecture	No domain graphic available
Description	Rhophilin-2 (GTP-Rho-binding protein 2).

SYP2L_HUMAN
θ value	0.0148317 (rank : 149)	NC score	0.236169 (rank : 151)
Query Neighborhood Hits	375	Target Neighborhood Hits	400	Shared Neighborhood Hits	126
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

LRRC7_HUMAN
θ value	0.0193708 (rank : 150)	NC score	0.125359 (rank : 234)
Query Neighborhood Hits	375	Target Neighborhood Hits	423	Shared Neighborhood Hits	110
SwissProt Accessions	Q96NW7, Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2	Gene names	LRRC7, KIAA1365, LAP1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

LRRC7_MOUSE
θ value	0.0193708 (rank : 151)	NC score	0.124502 (rank : 235)
Query Neighborhood Hits	375	Target Neighborhood Hits	416	Shared Neighborhood Hits	109
SwissProt Accessions	Q80TE7	Gene names	Lrrc7, Kiaa1365, Lap1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

APBA3_MOUSE
θ value	0.0252991 (rank : 152)	NC score	0.216415 (rank : 161)
Query Neighborhood Hits	375	Target Neighborhood Hits	174	Shared Neighborhood Hits	114
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

ARHG6_HUMAN
θ value	0.0252991 (rank : 153)	NC score	0.315368 (rank : 104)
Query Neighborhood Hits	375	Target Neighborhood Hits	376	Shared Neighborhood Hits	70
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

NIPBL_HUMAN
θ value	0.0252991 (rank : 154)	NC score	0.049874 (rank : 434)
Query Neighborhood Hits	375	Target Neighborhood Hits	1311	Shared Neighborhood Hits	83
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

PDLI7_HUMAN
θ value	0.0330416 (rank : 155)	NC score	0.131391 (rank : 221)
Query Neighborhood Hits	375	Target Neighborhood Hits	547	Shared Neighborhood Hits	123
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PZRN3_HUMAN
θ value	0.0330416 (rank : 156)	NC score	0.242860 (rank : 148)
Query Neighborhood Hits	375	Target Neighborhood Hits	461	Shared Neighborhood Hits	138
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

SI1L2_HUMAN
θ value	0.0330416 (rank : 157)	NC score	0.085182 (rank : 296)
Query Neighborhood Hits	375	Target Neighborhood Hits	131	Shared Neighborhood Hits	51
SwissProt Accessions	Q9P2F8, Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6	Gene names	SIPA1L2, KIAA1389
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

SYNP2_MOUSE
θ value	0.0330416 (rank : 158)	NC score	0.200137 (rank : 174)
Query Neighborhood Hits	375	Target Neighborhood Hits	252	Shared Neighborhood Hits	124
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

APBA2_HUMAN
θ value	0.0431538 (rank : 159)	NC score	0.214710 (rank : 164)
Query Neighborhood Hits	375	Target Neighborhood Hits	220	Shared Neighborhood Hits	124
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_MOUSE
θ value	0.0431538 (rank : 160)	NC score	0.215198 (rank : 163)
Query Neighborhood Hits	375	Target Neighborhood Hits	219	Shared Neighborhood Hits	128
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

FLIP1_MOUSE
θ value	0.0431538 (rank : 161)	NC score	0.046184 (rank : 440)
Query Neighborhood Hits	375	Target Neighborhood Hits	1176	Shared Neighborhood Hits	64
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

HTRA3_MOUSE
θ value	0.0431538 (rank : 162)	NC score	0.092769 (rank : 279)
Query Neighborhood Hits	375	Target Neighborhood Hits	156	Shared Neighborhood Hits	66
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

LIMK1_HUMAN
θ value	0.0431538 (rank : 163)	NC score	0.025083 (rank : 485)
Query Neighborhood Hits	375	Target Neighborhood Hits	1005	Shared Neighborhood Hits	86
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

SNTA1_HUMAN
θ value	0.0431538 (rank : 164)	NC score	0.261690 (rank : 133)
Query Neighborhood Hits	375	Target Neighborhood Hits	186	Shared Neighborhood Hits	142
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

ZO3_MOUSE
θ value	0.0431538 (rank : 165)	NC score	0.278140 (rank : 126)
Query Neighborhood Hits	375	Target Neighborhood Hits	224	Shared Neighborhood Hits	154
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

APBA1_HUMAN
θ value	0.0563607 (rank : 166)	NC score	0.219393 (rank : 160)
Query Neighborhood Hits	375	Target Neighborhood Hits	325	Shared Neighborhood Hits	132
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

GRASP_HUMAN
θ value	0.0563607 (rank : 167)	NC score	0.264632 (rank : 132)
Query Neighborhood Hits	375	Target Neighborhood Hits	147	Shared Neighborhood Hits	117
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

KIF17_MOUSE
θ value	0.0563607 (rank : 168)	NC score	0.015319 (rank : 517)
Query Neighborhood Hits	375	Target Neighborhood Hits	452	Shared Neighborhood Hits	33
SwissProt Accessions	Q99PW8	Gene names	Kif17
Domain Architecture
Description	Kinesin-like protein KIF17 (MmKIF17).

LDB3_HUMAN
θ value	0.0563607 (rank : 169)	NC score	0.137749 (rank : 214)
Query Neighborhood Hits	375	Target Neighborhood Hits	497	Shared Neighborhood Hits	121
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

PDLI5_HUMAN
θ value	0.0563607 (rank : 170)	NC score	0.138361 (rank : 212)
Query Neighborhood Hits	375	Target Neighborhood Hits	322	Shared Neighborhood Hits	117
SwissProt Accessions	Q96HC4, O60705	Gene names	PDLIM5, ENH
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

SYP2L_MOUSE
θ value	0.0563607 (rank : 171)	NC score	0.193584 (rank : 176)
Query Neighborhood Hits	375	Target Neighborhood Hits	289	Shared Neighborhood Hits	106
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

FLIP1_HUMAN
θ value	0.0736092 (rank : 172)	NC score	0.049617 (rank : 435)
Query Neighborhood Hits	375	Target Neighborhood Hits	1405	Shared Neighborhood Hits	64
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

LSP1_MOUSE
θ value	0.0736092 (rank : 173)	NC score	0.043380 (rank : 444)
Query Neighborhood Hits	375	Target Neighborhood Hits	125	Shared Neighborhood Hits	10
SwissProt Accessions	P19973, P97339, Q04950, Q62022, Q62023, Q62024, Q8CD28, Q99L65	Gene names	Lsp1, Pp52, S37, Wp34
Domain Architecture
Description	Lymphocyte-specific protein 1 (Protein pp52) (52 kDa phosphoprotein) (Lymphocyte-specific antigen WP34) (S37 protein).

PCNT_HUMAN
θ value	0.0736092 (rank : 174)	NC score	0.053544 (rank : 405)
Query Neighborhood Hits	375	Target Neighborhood Hits	1551	Shared Neighborhood Hits	76
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

PZRN4_HUMAN
θ value	0.0736092 (rank : 175)	NC score	0.244753 (rank : 147)
Query Neighborhood Hits	375	Target Neighborhood Hits	438	Shared Neighborhood Hits	135
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

SHC2_HUMAN
θ value	0.0736092 (rank : 176)	NC score	0.043587 (rank : 443)
Query Neighborhood Hits	375	Target Neighborhood Hits	170	Shared Neighborhood Hits	14
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SI1L2_MOUSE
θ value	0.0736092 (rank : 177)	NC score	0.083799 (rank : 299)
Query Neighborhood Hits	375	Target Neighborhood Hits	124	Shared Neighborhood Hits	53
SwissProt Accessions	Q80TE4, Q6PDY1	Gene names	Sipa1l2, Kiaa0545
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

DLG1_MOUSE
θ value	0.0961366 (rank : 178)	NC score	0.278953 (rank : 124)
Query Neighborhood Hits	375	Target Neighborhood Hits	285	Shared Neighborhood Hits	151
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

PDZD8_HUMAN
θ value	0.0961366 (rank : 179)	NC score	0.127463 (rank : 232)
Query Neighborhood Hits	375	Target Neighborhood Hits	185	Shared Neighborhood Hits	55
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

SI1L1_HUMAN
θ value	0.0961366 (rank : 180)	NC score	0.072528 (rank : 321)
Query Neighborhood Hits	375	Target Neighborhood Hits	162	Shared Neighborhood Hits	45
SwissProt Accessions	O43166, O95321, Q9UDU4, Q9UNU4	Gene names	SIPA1L1, E6TP1, KIAA0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1 (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6- targeted protein 1).

SI1L1_MOUSE
θ value	0.0961366 (rank : 181)	NC score	0.072361 (rank : 323)
Query Neighborhood Hits	375	Target Neighborhood Hits	189	Shared Neighborhood Hits	52
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

APBA3_HUMAN
θ value	0.125558 (rank : 182)	NC score	0.220838 (rank : 158)
Query Neighborhood Hits	375	Target Neighborhood Hits	201	Shared Neighborhood Hits	122
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

PDZK4_HUMAN
θ value	0.125558 (rank : 183)	NC score	0.185121 (rank : 178)
Query Neighborhood Hits	375	Target Neighborhood Hits	165	Shared Neighborhood Hits	106
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PRRT3_HUMAN
θ value	0.125558 (rank : 184)	NC score	0.048362 (rank : 436)
Query Neighborhood Hits	375	Target Neighborhood Hits	998	Shared Neighborhood Hits	65
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

ARI3A_HUMAN
θ value	0.163984 (rank : 185)	NC score	0.033937 (rank : 465)
Query Neighborhood Hits	375	Target Neighborhood Hits	80	Shared Neighborhood Hits	12
SwissProt Accessions	Q99856, Q8IZA7	Gene names	ARID3A, DRIL1, DRX, E2FBP1
Domain Architecture
Description	AT-rich interactive domain-containing protein 3A (ARID domain- containing protein 3A) (B-cell regulator of IgH transcription) (Bright) (E2F-binding protein 1).

GOGB1_HUMAN
θ value	0.163984 (rank : 186)	NC score	0.047786 (rank : 437)
Query Neighborhood Hits	375	Target Neighborhood Hits	2297	Shared Neighborhood Hits	92
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

GRASP_MOUSE
θ value	0.163984 (rank : 187)	NC score	0.258856 (rank : 138)
Query Neighborhood Hits	375	Target Neighborhood Hits	131	Shared Neighborhood Hits	117
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

MYH14_MOUSE
θ value	0.163984 (rank : 188)	NC score	0.025331 (rank : 484)
Query Neighborhood Hits	375	Target Neighborhood Hits	1225	Shared Neighborhood Hits	58
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

PDLI5_MOUSE
θ value	0.163984 (rank : 189)	NC score	0.134834 (rank : 219)
Query Neighborhood Hits	375	Target Neighborhood Hits	287	Shared Neighborhood Hits	111
SwissProt Accessions	Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2	Gene names	Pdlim5, Enh
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PDZK4_MOUSE
θ value	0.163984 (rank : 190)	NC score	0.188900 (rank : 177)
Query Neighborhood Hits	375	Target Neighborhood Hits	165	Shared Neighborhood Hits	109
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PHF20_HUMAN
θ value	0.163984 (rank : 191)	NC score	0.026018 (rank : 480)
Query Neighborhood Hits	375	Target Neighborhood Hits	394	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BVI0, Q5JWY9, Q9BWV4, Q9BXA3, Q9BZW3, Q9H421, Q9H4J6, Q9NZ22	Gene names	PHF20, C20orf104, GLEA2, HCA58, NZF, TZP
Domain Architecture
Description	PHD finger protein 20 (Hepatocellular carcinoma-associated antigen 58) (Glioma-expressed antigen 2) (Transcription factor TZP) (Novel zinc finger protein).

DLG1_HUMAN
θ value	0.21417 (rank : 192)	NC score	0.280451 (rank : 123)
Query Neighborhood Hits	375	Target Neighborhood Hits	290	Shared Neighborhood Hits	154
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

LAP2_HUMAN
θ value	0.21417 (rank : 193)	NC score	0.111655 (rank : 252)
Query Neighborhood Hits	375	Target Neighborhood Hits	499	Shared Neighborhood Hits	111
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

LAP2_MOUSE
θ value	0.21417 (rank : 194)	NC score	0.106740 (rank : 259)
Query Neighborhood Hits	375	Target Neighborhood Hits	482	Shared Neighborhood Hits	102
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

NOS1_HUMAN
θ value	0.21417 (rank : 195)	NC score	0.131552 (rank : 220)
Query Neighborhood Hits	375	Target Neighborhood Hits	218	Shared Neighborhood Hits	118
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

PDLI7_MOUSE
θ value	0.21417 (rank : 196)	NC score	0.123253 (rank : 236)
Query Neighborhood Hits	375	Target Neighborhood Hits	279	Shared Neighborhood Hits	97
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

ARHG6_MOUSE
θ value	0.279714 (rank : 197)	NC score	0.297086 (rank : 112)
Query Neighborhood Hits	375	Target Neighborhood Hits	394	Shared Neighborhood Hits	68
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

DLG5_HUMAN
θ value	0.279714 (rank : 198)	NC score	0.201441 (rank : 173)
Query Neighborhood Hits	375	Target Neighborhood Hits	1088	Shared Neighborhood Hits	195
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

HAPIP_HUMAN
θ value	0.279714 (rank : 199)	NC score	0.349133 (rank : 81)
Query Neighborhood Hits	375	Target Neighborhood Hits	350	Shared Neighborhood Hits	92
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

NCOA6_HUMAN
θ value	0.279714 (rank : 200)	NC score	0.045973 (rank : 441)
Query Neighborhood Hits	375	Target Neighborhood Hits	1202	Shared Neighborhood Hits	75
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

PDLI2_MOUSE
θ value	0.279714 (rank : 201)	NC score	0.213804 (rank : 166)
Query Neighborhood Hits	375	Target Neighborhood Hits	220	Shared Neighborhood Hits	119
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

PTN4_HUMAN
θ value	0.279714 (rank : 202)	NC score	0.098248 (rank : 270)
Query Neighborhood Hits	375	Target Neighborhood Hits	303	Shared Neighborhood Hits	115
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

SLK_MOUSE
θ value	0.279714 (rank : 203)	NC score	0.022085 (rank : 494)
Query Neighborhood Hits	375	Target Neighborhood Hits	1798	Shared Neighborhood Hits	76
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

SYNP2_HUMAN
θ value	0.279714 (rank : 204)	NC score	0.164437 (rank : 184)
Query Neighborhood Hits	375	Target Neighborhood Hits	323	Shared Neighborhood Hits	106
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

AFAD_HUMAN
θ value	0.365318 (rank : 205)	NC score	0.210522 (rank : 168)
Query Neighborhood Hits	375	Target Neighborhood Hits	689	Shared Neighborhood Hits	160
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

AKAP9_HUMAN
θ value	0.365318 (rank : 206)	NC score	0.046356 (rank : 438)
Query Neighborhood Hits	375	Target Neighborhood Hits	1710	Shared Neighborhood Hits	74
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

RHPN2_HUMAN
θ value	0.365318 (rank : 207)	NC score	0.099791 (rank : 268)
Query Neighborhood Hits	375	Target Neighborhood Hits	42	Shared Neighborhood Hits	22
SwissProt Accessions	Q8IUC4, Q8N3T7, Q8N9D6, Q8NE33, Q96RU1	Gene names	RHPN2
Domain Architecture	No domain graphic available
Description	Rhophilin-2 (GTP-Rho-binding protein 2) (76 kDa RhoB effector protein) (p76RBE).

GP153_MOUSE
θ value	0.47712 (rank : 208)	NC score	0.016655 (rank : 512)
Query Neighborhood Hits	375	Target Neighborhood Hits	204	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K0Z9, Q80T37, Q8CFK0	Gene names	Gpr153, Pgr1
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 153 (G-protein coupled receptor PGR1).

K1849_HUMAN
θ value	0.47712 (rank : 209)	NC score	0.220503 (rank : 159)
Query Neighborhood Hits	375	Target Neighborhood Hits	220	Shared Neighborhood Hits	125
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

PDZD6_HUMAN
θ value	0.47712 (rank : 210)	NC score	0.083189 (rank : 301)
Query Neighborhood Hits	375	Target Neighborhood Hits	81	Shared Neighborhood Hits	44
SwissProt Accessions	Q9ULD6, Q4W5I8, Q86V55	Gene names	PDZD6, KIAA1284, PDZK6
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 6.

SON_HUMAN
θ value	0.47712 (rank : 211)	NC score	0.033209 (rank : 467)
Query Neighborhood Hits	375	Target Neighborhood Hits	1568	Shared Neighborhood Hits	92
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

T22D4_HUMAN
θ value	0.47712 (rank : 212)	NC score	0.032589 (rank : 471)
Query Neighborhood Hits	375	Target Neighborhood Hits	403	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y3Q8	Gene names	TSC22D4, TILZ2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1).

TF3C1_HUMAN
θ value	0.47712 (rank : 213)	NC score	0.026458 (rank : 479)
Query Neighborhood Hits	375	Target Neighborhood Hits	88	Shared Neighborhood Hits	8
SwissProt Accessions	Q12789, Q12838, Q9Y4W9	Gene names	GTF3C1
Domain Architecture	No domain graphic available
Description	General transcription factor 3C polypeptide 1 (Transcription factor IIIC-subunit alpha) (TF3C-alpha) (TFIIIC 220 kDa subunit) (TFIIIC220) (TFIIIC box B-binding subunit).

GUAA_HUMAN
θ value	0.62314 (rank : 214)	NC score	0.033338 (rank : 466)
Query Neighborhood Hits	375	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P49915	Gene names	GMPS
Domain Architecture
Description	GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (Glutamine amidotransferase) (GMP synthetase).

PSCBP_HUMAN
θ value	0.62314 (rank : 215)	NC score	0.236742 (rank : 150)
Query Neighborhood Hits	375	Target Neighborhood Hits	123	Shared Neighborhood Hits	111
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

REST_HUMAN
θ value	0.62314 (rank : 216)	NC score	0.037858 (rank : 457)
Query Neighborhood Hits	375	Target Neighborhood Hits	1605	Shared Neighborhood Hits	67
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

SNTA1_MOUSE
θ value	0.62314 (rank : 217)	NC score	0.253788 (rank : 141)
Query Neighborhood Hits	375	Target Neighborhood Hits	170	Shared Neighborhood Hits	138
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

SYNE1_HUMAN
θ value	0.62314 (rank : 218)	NC score	0.040409 (rank : 447)
Query Neighborhood Hits	375	Target Neighborhood Hits	1484	Shared Neighborhood Hits	72
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

TXLNB_MOUSE
θ value	0.62314 (rank : 219)	NC score	0.039045 (rank : 454)
Query Neighborhood Hits	375	Target Neighborhood Hits	640	Shared Neighborhood Hits	52
SwissProt Accessions	Q8VBT1, Q3UVB8, Q8BUK2	Gene names	Txlnb, Mdp77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77).

ZBT7A_MOUSE
θ value	0.62314 (rank : 220)	NC score	-0.007519 (rank : 567)
Query Neighborhood Hits	375	Target Neighborhood Hits	795	Shared Neighborhood Hits	7
SwissProt Accessions	O88939, Q9CRJ0	Gene names	Zbtb7a, Lrf, Zbtb7
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 7A (Leukemia/lymphoma- related factor).

TX1B3_HUMAN
θ value	0.813845 (rank : 221)	NC score	0.311860 (rank : 105)
Query Neighborhood Hits	375	Target Neighborhood Hits	161	Shared Neighborhood Hits	136
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
θ value	0.813845 (rank : 222)	NC score	0.311793 (rank : 106)
Query Neighborhood Hits	375	Target Neighborhood Hits	158	Shared Neighborhood Hits	136
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

TXLNB_HUMAN
θ value	0.813845 (rank : 223)	NC score	0.040302 (rank : 449)
Query Neighborhood Hits	375	Target Neighborhood Hits	912	Shared Neighborhood Hits	77
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

HXA3_MOUSE
θ value	1.06291 (rank : 224)	NC score	0.007961 (rank : 549)
Query Neighborhood Hits	375	Target Neighborhood Hits	558	Shared Neighborhood Hits	37
SwissProt Accessions	P02831, Q4V9Z8, Q61197	Gene names	Hoxa3, Hox-1.5, Hoxa-3
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1.5) (MO-10).

MACF1_MOUSE
θ value	1.06291 (rank : 225)	NC score	0.025515 (rank : 482)
Query Neighborhood Hits	375	Target Neighborhood Hits	1313	Shared Neighborhood Hits	62
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

MY18A_MOUSE
θ value	1.06291 (rank : 226)	NC score	0.070481 (rank : 329)
Query Neighborhood Hits	375	Target Neighborhood Hits	1989	Shared Neighborhood Hits	169
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MYH4_HUMAN
θ value	1.06291 (rank : 227)	NC score	0.021117 (rank : 502)
Query Neighborhood Hits	375	Target Neighborhood Hits	1377	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

NACAM_MOUSE
θ value	1.06291 (rank : 228)	NC score	0.044552 (rank : 442)
Query Neighborhood Hits	375	Target Neighborhood Hits	1866	Shared Neighborhood Hits	110
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

PSCBP_MOUSE
θ value	1.06291 (rank : 229)	NC score	0.248101 (rank : 145)
Query Neighborhood Hits	375	Target Neighborhood Hits	118	Shared Neighborhood Hits	111
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

RGS14_MOUSE
θ value	1.06291 (rank : 230)	NC score	0.036627 (rank : 458)
Query Neighborhood Hits	375	Target Neighborhood Hits	55	Shared Neighborhood Hits	9
SwissProt Accessions	P97492, Q9DCD1	Gene names	Rgs14
Domain Architecture
Description	Regulator of G-protein signaling 14 (RGS14) (RAP1/RAP2-interacting protein).

SDCG8_MOUSE
θ value	1.06291 (rank : 231)	NC score	0.031758 (rank : 475)
Query Neighborhood Hits	375	Target Neighborhood Hits	886	Shared Neighborhood Hits	50
SwissProt Accessions	Q80UF4	Gene names	Sdccag8, Cccap
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (mCCCAP).

SNTG2_MOUSE
θ value	1.06291 (rank : 232)	NC score	0.250935 (rank : 143)
Query Neighborhood Hits	375	Target Neighborhood Hits	176	Shared Neighborhood Hits	140
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

ADIPO_MOUSE
θ value	1.38821 (rank : 233)	NC score	0.007674 (rank : 551)
Query Neighborhood Hits	375	Target Neighborhood Hits	182	Shared Neighborhood Hits	13
SwissProt Accessions	Q60994, Q62400, Q9DC68	Gene names	Adipoq, Acdc, Acrp30, Apm1
Domain Architecture
Description	Adiponectin precursor (Adipocyte, C1q and collagen domain-containing protein) (30 kDa adipocyte complement-related protein) (Adipocyte complement-related 30 kDa protein) (ACRP30) (Adipocyte-specific protein AdipoQ).

CONA1_MOUSE
θ value	1.38821 (rank : 234)	NC score	0.018788 (rank : 506)
Query Neighborhood Hits	375	Target Neighborhood Hits	254	Shared Neighborhood Hits	28
SwissProt Accessions	Q8K4G2, Q5SUQ0	Gene names	Col23a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXIII) chain.

FA47B_HUMAN
θ value	1.38821 (rank : 235)	NC score	0.024527 (rank : 490)
Query Neighborhood Hits	375	Target Neighborhood Hits	431	Shared Neighborhood Hits	24
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

GA2L2_HUMAN
θ value	1.38821 (rank : 236)	NC score	0.018239 (rank : 508)
Query Neighborhood Hits	375	Target Neighborhood Hits	175	Shared Neighborhood Hits	16
SwissProt Accessions	Q8NHY3, Q8NHY4	Gene names	GAS2L2, GAR17
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2) (GAS2-related protein on chromosome 17) (GAR17 protein).

HSF1_HUMAN
θ value	1.38821 (rank : 237)	NC score	0.015758 (rank : 515)
Query Neighborhood Hits	375	Target Neighborhood Hits	163	Shared Neighborhood Hits	11
SwissProt Accessions	Q00613	Gene names	HSF1, HSTF1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

SDCB1_HUMAN
θ value	1.38821 (rank : 238)	NC score	0.209652 (rank : 170)
Query Neighborhood Hits	375	Target Neighborhood Hits	150	Shared Neighborhood Hits	129
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

SDCB1_MOUSE
θ value	1.38821 (rank : 239)	NC score	0.214088 (rank : 165)
Query Neighborhood Hits	375	Target Neighborhood Hits	144	Shared Neighborhood Hits	127
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

SNTG2_HUMAN
θ value	1.38821 (rank : 240)	NC score	0.274784 (rank : 128)
Query Neighborhood Hits	375	Target Neighborhood Hits	191	Shared Neighborhood Hits	149
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

CK5P2_MOUSE
θ value	1.81305 (rank : 241)	NC score	0.036206 (rank : 459)
Query Neighborhood Hits	375	Target Neighborhood Hits	1151	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

CP250_HUMAN
θ value	1.81305 (rank : 242)	NC score	0.050097 (rank : 432)
Query Neighborhood Hits	375	Target Neighborhood Hits	1805	Shared Neighborhood Hits	72
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

DBP_MOUSE
θ value	1.81305 (rank : 243)	NC score	0.014317 (rank : 520)
Query Neighborhood Hits	375	Target Neighborhood Hits	137	Shared Neighborhood Hits	8
SwissProt Accessions	Q60925, Q8VCX3	Gene names	Dbp
Domain Architecture
Description	D site-binding protein (Albumin D box-binding protein) (Albumin D- element-binding protein).

PHLB1_HUMAN
θ value	1.81305 (rank : 244)	NC score	0.039354 (rank : 453)
Query Neighborhood Hits	375	Target Neighborhood Hits	1038	Shared Neighborhood Hits	78
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

ZN282_HUMAN
θ value	1.81305 (rank : 245)	NC score	-0.007914 (rank : 568)
Query Neighborhood Hits	375	Target Neighborhood Hits	796	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UDV7, O43691, Q6DKK0	Gene names	ZNF282, HUB1
Domain Architecture
Description	Zinc finger protein 282 (HTLV-I U5RE-binding protein 1) (HUB-1).

ZN385_HUMAN
θ value	1.81305 (rank : 246)	NC score	0.024931 (rank : 489)
Query Neighborhood Hits	375	Target Neighborhood Hits	614	Shared Neighborhood Hits	40
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

CE016_HUMAN
θ value	2.36792 (rank : 247)	NC score	0.019883 (rank : 505)
Query Neighborhood Hits	375	Target Neighborhood Hits	80	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NC24, Q6P4E7, Q6UXY2	Gene names	C5orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C5orf16.

CO9A2_HUMAN
θ value	2.36792 (rank : 248)	NC score	0.013428 (rank : 523)
Query Neighborhood Hits	375	Target Neighborhood Hits	261	Shared Neighborhood Hits	24
SwissProt Accessions	Q14055	Gene names	COL9A2
Domain Architecture	No domain graphic available
Description	Collagen alpha-2(IX) chain precursor.

DVL1_MOUSE
θ value	2.36792 (rank : 249)	NC score	0.136701 (rank : 218)
Query Neighborhood Hits	375	Target Neighborhood Hits	146	Shared Neighborhood Hits	102
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

EXTL1_HUMAN
θ value	2.36792 (rank : 250)	NC score	0.009549 (rank : 542)
Query Neighborhood Hits	375	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q92935, Q6GSC1	Gene names	EXTL1, EXTL
Domain Architecture
Description	Exostosin-like 1 (EC 2.4.1.224) (Glucuronosyl-N-acetylglucosaminyl- proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Exostosin-L) (Multiple exostosis-like protein).

GCH1_HUMAN
θ value	2.36792 (rank : 251)	NC score	0.018240 (rank : 507)
Query Neighborhood Hits	375	Target Neighborhood Hits	69	Shared Neighborhood Hits	5
SwissProt Accessions	P30793, Q9Y4I8	Gene names	GCH1, DYT5, GCH
Domain Architecture
Description	GTP cyclohydrolase I (EC 3.5.4.16) (GTP-CH-I).

GLDN_MOUSE
θ value	2.36792 (rank : 252)	NC score	0.010600 (rank : 535)
Query Neighborhood Hits	375	Target Neighborhood Hits	155	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BMF8, Q80ZC5	Gene names	Gldn, Crgl2
Domain Architecture	No domain graphic available
Description	Gliomedin (Cancer-related gene liver 2 protein) (CRG-L2).

JIP3_HUMAN
θ value	2.36792 (rank : 253)	NC score	0.052298 (rank : 415)
Query Neighborhood Hits	375	Target Neighborhood Hits	1039	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

MPP4_HUMAN
θ value	2.36792 (rank : 254)	NC score	0.163066 (rank : 185)
Query Neighborhood Hits	375	Target Neighborhood Hits	205	Shared Neighborhood Hits	115
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

MPP4_MOUSE
θ value	2.36792 (rank : 255)	NC score	0.144429 (rank : 200)
Query Neighborhood Hits	375	Target Neighborhood Hits	188	Shared Neighborhood Hits	99
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

PICK1_HUMAN
θ value	2.36792 (rank : 256)	NC score	0.161035 (rank : 186)
Query Neighborhood Hits	375	Target Neighborhood Hits	132	Shared Neighborhood Hits	98
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PICK1_MOUSE
θ value	2.36792 (rank : 257)	NC score	0.160351 (rank : 187)
Query Neighborhood Hits	375	Target Neighborhood Hits	131	Shared Neighborhood Hits	97
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

SFR14_MOUSE
θ value	2.36792 (rank : 258)	NC score	0.015796 (rank : 514)
Query Neighborhood Hits	375	Target Neighborhood Hits	238	Shared Neighborhood Hits	21
SwissProt Accessions	Q8CH09, Q6PG19, Q80UY8, Q8BY32, Q8CFM0	Gene names	Sfrs14
Domain Architecture	No domain graphic available
Description	Putative splicing factor, arginine/serine-rich 14 (Arginine/serine- rich-splicing factor 14).

STK10_MOUSE
θ value	2.36792 (rank : 259)	NC score	0.025671 (rank : 481)
Query Neighborhood Hits	375	Target Neighborhood Hits	2132	Shared Neighborhood Hits	87
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

TEX14_HUMAN
θ value	2.36792 (rank : 260)	NC score	0.009708 (rank : 539)
Query Neighborhood Hits	375	Target Neighborhood Hits	1103	Shared Neighborhood Hits	42
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

ZEP1_HUMAN
θ value	2.36792 (rank : 261)	NC score	-0.002285 (rank : 562)
Query Neighborhood Hits	375	Target Neighborhood Hits	1036	Shared Neighborhood Hits	30
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

DSPP_MOUSE
θ value	3.0926 (rank : 262)	NC score	0.027738 (rank : 478)
Query Neighborhood Hits	375	Target Neighborhood Hits	491	Shared Neighborhood Hits	28
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

DVL1_HUMAN
θ value	3.0926 (rank : 263)	NC score	0.139913 (rank : 207)
Query Neighborhood Hits	375	Target Neighborhood Hits	158	Shared Neighborhood Hits	103
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

IFT74_HUMAN
θ value	3.0926 (rank : 264)	NC score	0.039747 (rank : 451)
Query Neighborhood Hits	375	Target Neighborhood Hits	949	Shared Neighborhood Hits	48
SwissProt Accessions	Q96LB3, Q6PGQ8, Q9H643, Q9H8G7	Gene names	IFT74, CCDC2, CMG1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

MPP5_HUMAN
θ value	3.0926 (rank : 265)	NC score	0.154118 (rank : 192)
Query Neighborhood Hits	375	Target Neighborhood Hits	231	Shared Neighborhood Hits	114
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	3.0926 (rank : 266)	NC score	0.152984 (rank : 193)
Query Neighborhood Hits	375	Target Neighborhood Hits	226	Shared Neighborhood Hits	113
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

MRCKB_MOUSE
θ value	3.0926 (rank : 267)	NC score	0.035134 (rank : 461)
Query Neighborhood Hits	375	Target Neighborhood Hits	2180	Shared Neighborhood Hits	92
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

PDLI2_HUMAN
θ value	3.0926 (rank : 268)	NC score	0.211807 (rank : 167)
Query Neighborhood Hits	375	Target Neighborhood Hits	245	Shared Neighborhood Hits	124
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

RASA1_HUMAN
θ value	3.0926 (rank : 269)	NC score	0.025446 (rank : 483)
Query Neighborhood Hits	375	Target Neighborhood Hits	258	Shared Neighborhood Hits	16
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RFX1_HUMAN
θ value	3.0926 (rank : 270)	NC score	0.013367 (rank : 524)
Query Neighborhood Hits	375	Target Neighborhood Hits	256	Shared Neighborhood Hits	25
SwissProt Accessions	P22670	Gene names	RFX1
Domain Architecture
Description	MHC class II regulatory factor RFX1 (RFX) (Enhancer factor C) (EF-C).

SI1L3_HUMAN
θ value	3.0926 (rank : 271)	NC score	0.063300 (rank : 361)
Query Neighborhood Hits	375	Target Neighborhood Hits	305	Shared Neighborhood Hits	52
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

SNTG1_MOUSE
θ value	3.0926 (rank : 272)	NC score	0.259160 (rank : 137)
Query Neighborhood Hits	375	Target Neighborhood Hits	179	Shared Neighborhood Hits	143
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SOX30_HUMAN
θ value	3.0926 (rank : 273)	NC score	0.008366 (rank : 546)
Query Neighborhood Hits	375	Target Neighborhood Hits	305	Shared Neighborhood Hits	16
SwissProt Accessions	O94993, O94995, Q8IYX6	Gene names	SOX30
Domain Architecture
Description	Transcription factor SOX-30.

TTDN1_MOUSE
θ value	3.0926 (rank : 274)	NC score	0.025035 (rank : 487)
Query Neighborhood Hits	375	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D011	Gene names	Ttdn1
Domain Architecture	No domain graphic available
Description	TTD non-photosensitive 1 protein homolog.

TULP4_HUMAN
θ value	3.0926 (rank : 275)	NC score	0.013265 (rank : 525)
Query Neighborhood Hits	375	Target Neighborhood Hits	426	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NRJ4, Q9HD22, Q9P2F0	Gene names	TULP4, KIAA1397, TUSP
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

TXLNA_HUMAN
θ value	3.0926 (rank : 276)	NC score	0.040225 (rank : 450)
Query Neighborhood Hits	375	Target Neighborhood Hits	982	Shared Neighborhood Hits	67
SwissProt Accessions	P40222, Q66K62, Q86T54, Q86T85, Q86T86, Q86Y86, Q86YW3, Q8N2Y3	Gene names	TXLNA, TXLN
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

TXLNA_MOUSE
θ value	3.0926 (rank : 277)	NC score	0.041747 (rank : 446)
Query Neighborhood Hits	375	Target Neighborhood Hits	846	Shared Neighborhood Hits	54
SwissProt Accessions	Q6PAM1, Q6P1E5	Gene names	Txlna, Txln
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

ZN694_HUMAN
θ value	3.0926 (rank : 278)	NC score	-0.008476 (rank : 569)
Query Neighborhood Hits	375	Target Neighborhood Hits	764	Shared Neighborhood Hits	10
SwissProt Accessions	Q63HK3, Q6ZN77	Gene names	ZNF694
Domain Architecture	No domain graphic available
Description	Zinc finger protein 694.

BLK_MOUSE
θ value	4.03905 (rank : 279)	NC score	0.015514 (rank : 516)
Query Neighborhood Hits	375	Target Neighborhood Hits	992	Shared Neighborhood Hits	38
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CJ006_HUMAN
θ value	4.03905 (rank : 280)	NC score	0.016753 (rank : 511)
Query Neighborhood Hits	375	Target Neighborhood Hits	122	Shared Neighborhood Hits	12
SwissProt Accessions	Q8IX21, Q5W0L8, Q9NPE8	Gene names	C10orf6
Domain Architecture	No domain graphic available
Description	Protein C10orf6.

CO4A2_MOUSE
θ value	4.03905 (rank : 281)	NC score	0.010842 (rank : 534)
Query Neighborhood Hits	375	Target Neighborhood Hits	492	Shared Neighborhood Hits	38
SwissProt Accessions	P08122, Q61375	Gene names	Col4a2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

CTRO_MOUSE
θ value	4.03905 (rank : 282)	NC score	0.031824 (rank : 474)
Query Neighborhood Hits	375	Target Neighborhood Hits	2344	Shared Neighborhood Hits	91
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

HXA3_HUMAN
θ value	4.03905 (rank : 283)	NC score	0.005332 (rank : 556)
Query Neighborhood Hits	375	Target Neighborhood Hits	535	Shared Neighborhood Hits	39
SwissProt Accessions	O43365	Gene names	HOXA3, HOX1E
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1E).

IL16_HUMAN
θ value	4.03905 (rank : 284)	NC score	0.242147 (rank : 149)
Query Neighborhood Hits	375	Target Neighborhood Hits	207	Shared Neighborhood Hits	122
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

MECP2_HUMAN
θ value	4.03905 (rank : 285)	NC score	0.021971 (rank : 495)
Query Neighborhood Hits	375	Target Neighborhood Hits	92	Shared Neighborhood Hits	14
SwissProt Accessions	P51608, O15233	Gene names	MECP2
Domain Architecture
Description	Methyl-CpG-binding protein 2 (MeCP-2 protein) (MeCP2).

MYH14_HUMAN
θ value	4.03905 (rank : 286)	NC score	0.021916 (rank : 497)
Query Neighborhood Hits	375	Target Neighborhood Hits	995	Shared Neighborhood Hits	49
SwissProt Accessions	Q7Z406, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882	Gene names	MYH14, KIAA2034
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

PDLI3_MOUSE
θ value	4.03905 (rank : 287)	NC score	0.139700 (rank : 209)
Query Neighborhood Hits	375	Target Neighborhood Hits	197	Shared Neighborhood Hits	101
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PDLI4_HUMAN
θ value	4.03905 (rank : 288)	NC score	0.141953 (rank : 204)
Query Neighborhood Hits	375	Target Neighborhood Hits	245	Shared Neighborhood Hits	107
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

SLIK5_HUMAN
θ value	4.03905 (rank : 289)	NC score	0.004405 (rank : 557)
Query Neighborhood Hits	375	Target Neighborhood Hits	302	Shared Neighborhood Hits	13
SwissProt Accessions	O94991	Gene names	SLITRK5, KIAA0918, LRRC11
Domain Architecture
Description	SLIT and NTRK-like protein 5 precursor (Leucine-rich repeat-containing protein 11).

SNTG1_HUMAN
θ value	4.03905 (rank : 290)	NC score	0.260270 (rank : 135)
Query Neighborhood Hits	375	Target Neighborhood Hits	181	Shared Neighborhood Hits	143
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SOX10_HUMAN
θ value	4.03905 (rank : 291)	NC score	0.006251 (rank : 553)
Query Neighborhood Hits	375	Target Neighborhood Hits	122	Shared Neighborhood Hits	10
SwissProt Accessions	P56693	Gene names	SOX10
Domain Architecture
Description	Transcription factor SOX-10.

ZMYM3_HUMAN
θ value	4.03905 (rank : 292)	NC score	0.016769 (rank : 510)
Query Neighborhood Hits	375	Target Neighborhood Hits	223	Shared Neighborhood Hits	20
SwissProt Accessions	Q14202, O15089	Gene names	ZMYM3, DXS6673E, KIAA0385, ZNF261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261).

ZN142_HUMAN
θ value	4.03905 (rank : 293)	NC score	-0.006718 (rank : 566)
Query Neighborhood Hits	375	Target Neighborhood Hits	1007	Shared Neighborhood Hits	28
SwissProt Accessions	P52746, Q92510	Gene names	ZNF142, KIAA0236
Domain Architecture	No domain graphic available
Description	Zinc finger protein 142 (HA4654).

AKAP2_MOUSE
θ value	5.27518 (rank : 294)	NC score	0.032826 (rank : 470)
Query Neighborhood Hits	375	Target Neighborhood Hits	385	Shared Neighborhood Hits	42
SwissProt Accessions	O54931, O54932, O54933	Gene names	Akap2
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2) (AKAP expressed in kidney and lung) (AKAP-KL).

AQR_HUMAN
θ value	5.27518 (rank : 295)	NC score	0.009154 (rank : 543)
Query Neighborhood Hits	375	Target Neighborhood Hits	88	Shared Neighborhood Hits	7
SwissProt Accessions	O60306, Q2YDX9, Q6IRU8, Q6PIC8	Gene names	AQR, KIAA0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius (Intron-binding protein of 160 kDa) (IBP160).

BCL9_MOUSE
θ value	5.27518 (rank : 296)	NC score	0.031880 (rank : 473)
Query Neighborhood Hits	375	Target Neighborhood Hits	770	Shared Neighborhood Hits	58
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

COEA1_HUMAN
θ value	5.27518 (rank : 297)	NC score	0.008130 (rank : 547)
Query Neighborhood Hits	375	Target Neighborhood Hits	427	Shared Neighborhood Hits	26
SwissProt Accessions	Q05707, O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67	Gene names	COL14A1, UND
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor (Undulin).

DVL3_HUMAN
θ value	5.27518 (rank : 298)	NC score	0.137221 (rank : 216)
Query Neighborhood Hits	375	Target Neighborhood Hits	194	Shared Neighborhood Hits	102
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_MOUSE
θ value	5.27518 (rank : 299)	NC score	0.137408 (rank : 215)
Query Neighborhood Hits	375	Target Neighborhood Hits	198	Shared Neighborhood Hits	103
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

GTSE1_MOUSE
θ value	5.27518 (rank : 300)	NC score	0.023925 (rank : 492)
Query Neighborhood Hits	375	Target Neighborhood Hits	245	Shared Neighborhood Hits	24
SwissProt Accessions	Q8R080, O89015, Q9CSG9	Gene names	Gtse1, B99
Domain Architecture	No domain graphic available
Description	G2 and S phase expressed protein 1 (Gtse-1) (B99 protein).

L2GL1_HUMAN
θ value	5.27518 (rank : 301)	NC score	0.005576 (rank : 555)
Query Neighborhood Hits	375	Target Neighborhood Hits	64	Shared Neighborhood Hits	4
SwissProt Accessions	Q15334, O00188, Q58F11, Q86UK6	Gene names	LLGL1, HUGL
Domain Architecture	No domain graphic available
Description	Lethal(2) giant larvae protein homolog 1 (LLGL) (Human homolog to the D-lgl gene) (Hugl-1) (DLG4).

MECP2_MOUSE
θ value	5.27518 (rank : 302)	NC score	0.021628 (rank : 500)
Query Neighborhood Hits	375	Target Neighborhood Hits	76	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Z2D6	Gene names	Mecp2
Domain Architecture
Description	Methyl-CpG-binding protein 2 (MeCP-2 protein) (MeCP2).

MY18A_HUMAN
θ value	5.27518 (rank : 303)	NC score	0.067517 (rank : 337)
Query Neighborhood Hits	375	Target Neighborhood Hits	1929	Shared Neighborhood Hits	168
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MYRIP_MOUSE
θ value	5.27518 (rank : 304)	NC score	0.022926 (rank : 493)
Query Neighborhood Hits	375	Target Neighborhood Hits	207	Shared Neighborhood Hits	19
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

N4BP3_HUMAN
θ value	5.27518 (rank : 305)	NC score	0.020754 (rank : 503)
Query Neighborhood Hits	375	Target Neighborhood Hits	156	Shared Neighborhood Hits	16
SwissProt Accessions	O15049, Q7Z6I3	Gene names	N4BP3, KIAA0341
Domain Architecture
Description	NEDD4-binding protein 3 (N4BP3).

OBSCN_HUMAN
θ value	5.27518 (rank : 306)	NC score	0.057835 (rank : 386)
Query Neighborhood Hits	375	Target Neighborhood Hits	1931	Shared Neighborhood Hits	108
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

PDLI4_MOUSE
θ value	5.27518 (rank : 307)	NC score	0.144823 (rank : 199)
Query Neighborhood Hits	375	Target Neighborhood Hits	233	Shared Neighborhood Hits	109
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PRRT3_MOUSE
θ value	5.27518 (rank : 308)	NC score	0.032427 (rank : 472)
Query Neighborhood Hits	375	Target Neighborhood Hits	162	Shared Neighborhood Hits	17
SwissProt Accessions	Q6PE13	Gene names	Prrt3
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

PTN3_HUMAN
θ value	5.27518 (rank : 309)	NC score	0.094714 (rank : 277)
Query Neighborhood Hits	375	Target Neighborhood Hits	258	Shared Neighborhood Hits	115
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

RGS1_MOUSE
θ value	5.27518 (rank : 310)	NC score	0.025042 (rank : 486)
Query Neighborhood Hits	375	Target Neighborhood Hits	60	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JL25, Q3TBD1, Q3TC18, Q3TD56	Gene names	Rgs1
Domain Architecture
Description	Regulator of G-protein signaling 1 (RGS1).

RP1L1_MOUSE
θ value	5.27518 (rank : 311)	NC score	0.012490 (rank : 530)
Query Neighborhood Hits	375	Target Neighborhood Hits	170	Shared Neighborhood Hits	14
SwissProt Accessions	Q8CGM2, Q8K0I4	Gene names	Rp1l1, Rp1hl1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein (Retinitis pigmentosa 1-like protein 1).

SOX9_HUMAN
θ value	5.27518 (rank : 312)	NC score	0.007549 (rank : 552)
Query Neighborhood Hits	375	Target Neighborhood Hits	210	Shared Neighborhood Hits	19
SwissProt Accessions	P48436	Gene names	SOX9
Domain Architecture
Description	Transcription factor SOX-9.

SRPK1_HUMAN
θ value	5.27518 (rank : 313)	NC score	0.010021 (rank : 537)
Query Neighborhood Hits	375	Target Neighborhood Hits	706	Shared Neighborhood Hits	32
SwissProt Accessions	Q96SB4, Q12890, Q5R364, Q5R365, Q8IY12	Gene names	SRPK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

SRRM2_MOUSE
θ value	5.27518 (rank : 314)	NC score	0.062228 (rank : 364)
Query Neighborhood Hits	375	Target Neighborhood Hits	1470	Shared Neighborhood Hits	107
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

TCOF_MOUSE
θ value	5.27518 (rank : 315)	NC score	0.052544 (rank : 412)
Query Neighborhood Hits	375	Target Neighborhood Hits	471	Shared Neighborhood Hits	43
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

TTC28_HUMAN
θ value	5.27518 (rank : 316)	NC score	0.013770 (rank : 522)
Query Neighborhood Hits	375	Target Neighborhood Hits	271	Shared Neighborhood Hits	21
SwissProt Accessions	Q96AY4, O95928, O95929, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5	Gene names	TTC28, KIAA1043
Domain Architecture
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

TTDN1_HUMAN
θ value	5.27518 (rank : 317)	NC score	0.021819 (rank : 498)
Query Neighborhood Hits	375	Target Neighborhood Hits	43	Shared Neighborhood Hits	7
SwissProt Accessions	Q8TAP9	Gene names	TTDN1, C7orf11
Domain Architecture	No domain graphic available
Description	TTD non-photosensitive 1 protein.

ABR_HUMAN
θ value	6.88961 (rank : 318)	NC score	0.258425 (rank : 139)
Query Neighborhood Hits	375	Target Neighborhood Hits	166	Shared Neighborhood Hits	61
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

BARH1_MOUSE
θ value	6.88961 (rank : 319)	NC score	-0.003048 (rank : 564)
Query Neighborhood Hits	375	Target Neighborhood Hits	350	Shared Neighborhood Hits	4
SwissProt Accessions	P63157, Q9JK26	Gene names	Barhl1, Bhx1, Mbh2
Domain Architecture	No domain graphic available
Description	BarH-like 1 homeobox protein (Bar-class homeodomain protein MBH2) (BarH-related homeobox protein 1).

CABL2_MOUSE
θ value	6.88961 (rank : 320)	NC score	0.009573 (rank : 541)
Query Neighborhood Hits	375	Target Neighborhood Hits	79	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K3M5	Gene names	Cables2
Domain Architecture
Description	CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2).

CAR11_HUMAN
θ value	6.88961 (rank : 321)	NC score	0.067496 (rank : 338)
Query Neighborhood Hits	375	Target Neighborhood Hits	690	Shared Neighborhood Hits	76
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

CEP68_MOUSE
θ value	6.88961 (rank : 322)	NC score	0.014304 (rank : 521)
Query Neighborhood Hits	375	Target Neighborhood Hits	62	Shared Neighborhood Hits	9
SwissProt Accessions	Q8C0D9, Q3US49, Q5SW85, Q8R2V0	Gene names	Cep68
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 68 kDa (Cep68 protein).

CLPB_HUMAN
θ value	6.88961 (rank : 323)	NC score	0.003912 (rank : 558)
Query Neighborhood Hits	375	Target Neighborhood Hits	265	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H078, Q8ND11, Q9H8Y0	Gene names	CLPB, SKD3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

CO8A2_HUMAN
θ value	6.88961 (rank : 324)	NC score	0.020670 (rank : 504)
Query Neighborhood Hits	375	Target Neighborhood Hits	299	Shared Neighborhood Hits	27
SwissProt Accessions	P25067, Q8TEJ5	Gene names	COL8A2
Domain Architecture
Description	Collagen alpha-2(VIII) chain precursor (Endothelial collagen).

CP250_MOUSE
θ value	6.88961 (rank : 325)	NC score	0.046265 (rank : 439)
Query Neighborhood Hits	375	Target Neighborhood Hits	1583	Shared Neighborhood Hits	69
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

CSPG2_HUMAN
θ value	6.88961 (rank : 326)	NC score	-0.002788 (rank : 563)
Query Neighborhood Hits	375	Target Neighborhood Hits	681	Shared Neighborhood Hits	12
SwissProt Accessions	P13611, P20754, Q13010, Q13189, Q15123, Q9UCL9, Q9UNW5	Gene names	CSPG2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M) (Glial hyaluronate-binding protein) (GHAP).

DDFL1_HUMAN
θ value	6.88961 (rank : 327)	NC score	0.005608 (rank : 554)
Query Neighborhood Hits	375	Target Neighborhood Hits	353	Shared Neighborhood Hits	13
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

GIPC1_HUMAN
θ value	6.88961 (rank : 328)	NC score	0.083632 (rank : 300)
Query Neighborhood Hits	375	Target Neighborhood Hits	91	Shared Neighborhood Hits	66
SwissProt Accessions	O14908, Q9BTC9	Gene names	GIPC1, C19orf3, GIPC, RGS19IP1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Tax interaction protein 2) (TIP-2).

JIP4_HUMAN
θ value	6.88961 (rank : 329)	NC score	0.032864 (rank : 468)
Query Neighborhood Hits	375	Target Neighborhood Hits	585	Shared Neighborhood Hits	42
SwissProt Accessions	O60271, O60905, Q3KQU8, Q3MKM7, Q86WC7, Q86WC8, Q8IZX7, Q96II0, Q9H811	Gene names	SPAG9, HSS, KIAA0516, MAPK8IP4, SYD1
Domain Architecture	No domain graphic available
Description	C-jun-amino-terminal kinase-interacting protein 4 (JNK-interacting protein 4) (JIP-4) (JNK-associated leucine-zipper protein) (JLP) (Sperm-associated antigen 9) (Mitogen-activated protein kinase 8- interacting protein 4) (Human lung cancer protein 6) (HLC-6) (Proliferation-inducing protein 6) (Sperm-specific protein) (Sperm surface protein) (Protein highly expressed in testis) (PHET) (Sunday driver 1).

LUZP1_MOUSE
θ value	6.88961 (rank : 330)	NC score	0.042298 (rank : 445)
Query Neighborhood Hits	375	Target Neighborhood Hits	940	Shared Neighborhood Hits	55
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

MACF1_HUMAN
θ value	6.88961 (rank : 331)	NC score	0.029842 (rank : 477)
Query Neighborhood Hits	375	Target Neighborhood Hits	1341	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

MACF4_HUMAN
θ value	6.88961 (rank : 332)	NC score	0.034145 (rank : 464)
Query Neighborhood Hits	375	Target Neighborhood Hits	1321	Shared Neighborhood Hits	68
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

MINK1_HUMAN
θ value	6.88961 (rank : 333)	NC score	0.016365 (rank : 513)
Query Neighborhood Hits	375	Target Neighborhood Hits	1477	Shared Neighborhood Hits	73
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MYO15_HUMAN
θ value	6.88961 (rank : 334)	NC score	0.014428 (rank : 519)
Query Neighborhood Hits	375	Target Neighborhood Hits	671	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

NFAC2_HUMAN
θ value	6.88961 (rank : 335)	NC score	0.007982 (rank : 548)
Query Neighborhood Hits	375	Target Neighborhood Hits	101	Shared Neighborhood Hits	14
SwissProt Accessions	Q13469, Q13468, Q5TFW7, Q5TFW8, Q9NPX6, Q9NQH3, Q9UJR2	Gene names	NFATC2, NFAT1, NFATP
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 2 (T cell transcription factor NFAT1) (NFAT pre-existing subunit) (NF-ATp).

NTKL_HUMAN
θ value	6.88961 (rank : 336)	NC score	0.010600 (rank : 536)
Query Neighborhood Hits	375	Target Neighborhood Hits	266	Shared Neighborhood Hits	14
SwissProt Accessions	Q96KG9, Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53	Gene names	SCYL1, GKLP, NTKL, TAPK, TEIF, TRAP
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (Teratoma- associated tyrosine kinase) (Telomerase transcriptional element- interacting factor) (Telomerase regulation-associated protein).

PCLO_HUMAN
θ value	6.88961 (rank : 337)	NC score	0.053279 (rank : 406)
Query Neighborhood Hits	375	Target Neighborhood Hits	2046	Shared Neighborhood Hits	132
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PDLI1_HUMAN
θ value	6.88961 (rank : 338)	NC score	0.142279 (rank : 202)
Query Neighborhood Hits	375	Target Neighborhood Hits	242	Shared Neighborhood Hits	97
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PDLI3_HUMAN
θ value	6.88961 (rank : 339)	NC score	0.144927 (rank : 198)
Query Neighborhood Hits	375	Target Neighborhood Hits	199	Shared Neighborhood Hits	104
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PHLA1_HUMAN
θ value	6.88961 (rank : 340)	NC score	0.014807 (rank : 518)
Query Neighborhood Hits	375	Target Neighborhood Hits	121	Shared Neighborhood Hits	12
SwissProt Accessions	Q8WV24, Q15184, Q2TAN2, Q9NZ17	Gene names	PHLDA1, PHRIP, TDAG51
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family A member 1 (T-cell death- associated gene 51 protein) (Apoptosis-associated nuclear protein) (Proline- and histidine-rich protein) (Proline- and glutamine-rich protein) (PQ-rich protein).

RB6I2_HUMAN
θ value	6.88961 (rank : 341)	NC score	0.038714 (rank : 455)
Query Neighborhood Hits	375	Target Neighborhood Hits	1584	Shared Neighborhood Hits	72
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

RGS14_HUMAN
θ value	6.88961 (rank : 342)	NC score	0.034327 (rank : 463)
Query Neighborhood Hits	375	Target Neighborhood Hits	77	Shared Neighborhood Hits	12
SwissProt Accessions	O43566, O43565, Q8TD62	Gene names	RGS14
Domain Architecture
Description	Regulator of G-protein signaling 14 (RGS14).

SNTB1_HUMAN
θ value	6.88961 (rank : 343)	NC score	0.234913 (rank : 152)
Query Neighborhood Hits	375	Target Neighborhood Hits	157	Shared Neighborhood Hits	129
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

SNTB1_MOUSE
θ value	6.88961 (rank : 344)	NC score	0.234652 (rank : 153)
Query Neighborhood Hits	375	Target Neighborhood Hits	160	Shared Neighborhood Hits	130
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

TXD12_HUMAN
θ value	6.88961 (rank : 345)	NC score	0.012382 (rank : 531)
Query Neighborhood Hits	375	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	O95881, Q5T1T4, Q96H50	Gene names	TXNDC12, TLP19
Domain Architecture
Description	Thioredoxin domain-containing protein 12 precursor (EC 1.8.4.2) (Thioredoxin-like protein p19) (Endoplasmic reticulum protein ERp19) (ERp18) (hTLP19).

TXD12_MOUSE
θ value	6.88961 (rank : 346)	NC score	0.012365 (rank : 532)
Query Neighborhood Hits	375	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CQU0, Q53YN1	Gene names	Txndc12, Tlp19
Domain Architecture
Description	Thioredoxin domain-containing protein 12 precursor (EC 1.8.4.2) (Thioredoxin-like protein p19) (Endoplasmic reticulum protein ERp19).

ZIM10_MOUSE
θ value	6.88961 (rank : 347)	NC score	0.008510 (rank : 544)
Query Neighborhood Hits	375	Target Neighborhood Hits	430	Shared Neighborhood Hits	29
SwissProt Accessions	Q6P1E1, Q6PDK9, Q6PF85, Q8BW47	Gene names	Rai17, Zimp10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

BCL9_HUMAN
θ value	8.99809 (rank : 348)	NC score	0.030764 (rank : 476)
Query Neighborhood Hits	375	Target Neighborhood Hits	1008	Shared Neighborhood Hits	70
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

CCD46_MOUSE
θ value	8.99809 (rank : 349)	NC score	0.040374 (rank : 448)
Query Neighborhood Hits	375	Target Neighborhood Hits	1405	Shared Neighborhood Hits	68
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

CHD1_HUMAN
θ value	8.99809 (rank : 350)	NC score	0.003784 (rank : 559)
Query Neighborhood Hits	375	Target Neighborhood Hits	337	Shared Neighborhood Hits	21
SwissProt Accessions	O14646	Gene names	CHD1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

CO9A2_MOUSE
θ value	8.99809 (rank : 351)	NC score	0.012610 (rank : 529)
Query Neighborhood Hits	375	Target Neighborhood Hits	279	Shared Neighborhood Hits	22
SwissProt Accessions	Q07643	Gene names	Col9a2
Domain Architecture	No domain graphic available
Description	Collagen alpha-2(IX) chain precursor.

EM55_MOUSE
θ value	8.99809 (rank : 352)	NC score	0.139625 (rank : 210)
Query Neighborhood Hits	375	Target Neighborhood Hits	221	Shared Neighborhood Hits	108
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

FILA_HUMAN
θ value	8.99809 (rank : 353)	NC score	0.012845 (rank : 528)
Query Neighborhood Hits	375	Target Neighborhood Hits	685	Shared Neighborhood Hits	37
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

FOXD2_HUMAN
θ value	8.99809 (rank : 354)	NC score	-0.000803 (rank : 561)
Query Neighborhood Hits	375	Target Neighborhood Hits	143	Shared Neighborhood Hits	8
SwissProt Accessions	O60548	Gene names	FOXD2, FKHL17, FREAC9
Domain Architecture
Description	Forkhead box protein D2 (Forkhead-related protein FKHL17) (Forkhead- related transcription factor 9) (FREAC-9).

GIPC1_MOUSE
θ value	8.99809 (rank : 355)	NC score	0.086949 (rank : 291)
Query Neighborhood Hits	375	Target Neighborhood Hits	92	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Z0G0	Gene names	Gipc1, Gipc, Rgs19ip1, Semcap1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Synectin) (SemaF cytoplasmic domain-associated protein 1) (SEMCAP-1).

GLI3_HUMAN
θ value	8.99809 (rank : 356)	NC score	-0.006207 (rank : 565)
Query Neighborhood Hits	375	Target Neighborhood Hits	871	Shared Neighborhood Hits	23
SwissProt Accessions	P10071, O75219, Q9UDT5, Q9UJ39	Gene names	GLI3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI3.

GR65_HUMAN
θ value	8.99809 (rank : 357)	NC score	0.013261 (rank : 526)
Query Neighborhood Hits	375	Target Neighborhood Hits	148	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BQQ3, Q8N272, Q96H42	Gene names	GORASP1, GRASP65
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 1 (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5).

HTRA1_HUMAN
θ value	8.99809 (rank : 358)	NC score	0.053639 (rank : 404)
Query Neighborhood Hits	375	Target Neighborhood Hits	155	Shared Neighborhood Hits	48
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

INVS_MOUSE
θ value	8.99809 (rank : 359)	NC score	0.000082 (rank : 560)
Query Neighborhood Hits	375	Target Neighborhood Hits	609	Shared Neighborhood Hits	21
SwissProt Accessions	O89019, O88849	Gene names	Invs, Inv, Nphp2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning protein) (Nephrocystin-2).

K1958_HUMAN
θ value	8.99809 (rank : 360)	NC score	0.007816 (rank : 550)
Query Neighborhood Hits	375	Target Neighborhood Hits	76	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N8K9, Q5T252, Q8TF43, Q96N02	Gene names	KIAA1958
Domain Architecture	No domain graphic available
Description	Protein KIAA1958.

MAP1A_HUMAN
θ value	8.99809 (rank : 361)	NC score	0.038018 (rank : 456)
Query Neighborhood Hits	375	Target Neighborhood Hits	1626	Shared Neighborhood Hits	95
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

NEST_HUMAN
θ value	8.99809 (rank : 362)	NC score	0.035293 (rank : 460)
Query Neighborhood Hits	375	Target Neighborhood Hits	1305	Shared Neighborhood Hits	80
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

NHEJ1_MOUSE
θ value	8.99809 (rank : 363)	NC score	0.008428 (rank : 545)
Query Neighborhood Hits	375	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q3KNJ2, Q99JK0, Q9D9U0	Gene names	Nhej1, Xlf
Domain Architecture	No domain graphic available
Description	Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor).

PDXL2_MOUSE
θ value	8.99809 (rank : 364)	NC score	0.017975 (rank : 509)
Query Neighborhood Hits	375	Target Neighborhood Hits	213	Shared Neighborhood Hits	23
SwissProt Accessions	Q8CAE9, Q8CFW3	Gene names	Podxl2
Domain Architecture	No domain graphic available
Description	Podocalyxin-like protein 2 precursor (Endoglycan).

PKCB1_HUMAN
θ value	8.99809 (rank : 365)	NC score	0.012094 (rank : 533)
Query Neighborhood Hits	375	Target Neighborhood Hits	488	Shared Neighborhood Hits	29
SwissProt Accessions	Q9ULU4, Q13517, Q4JJ94, Q4JJ95, Q5TH09, Q6MZM1, Q8WXC5, Q9H1F3, Q9H1F4, Q9H1F5, Q9H1L8, Q9H1L9, Q9H2G5, Q9NYN3, Q9UIX6	Gene names	PRKCBP1, KIAA1125, RACK7, ZMYND8
Domain Architecture
Description	Protein kinase C-binding protein 1 (Rack7) (Cutaneous T-cell lymphoma- associated antigen se14-3) (CTCL tumor antigen se14-3) (Zinc finger MYND domain-containing protein 8).

PRP1_HUMAN
θ value	8.99809 (rank : 366)	NC score	0.032827 (rank : 469)
Query Neighborhood Hits	375	Target Neighborhood Hits	385	Shared Neighborhood Hits	41
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

RB6I2_MOUSE
θ value	8.99809 (rank : 367)	NC score	0.039614 (rank : 452)
Query Neighborhood Hits	375	Target Neighborhood Hits	1433	Shared Neighborhood Hits	65
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

RGS2_MOUSE
θ value	8.99809 (rank : 368)	NC score	0.024484 (rank : 491)
Query Neighborhood Hits	375	Target Neighborhood Hits	52	Shared Neighborhood Hits	9
SwissProt Accessions	O08849, Q544S7, Q91WX1, Q9JL24	Gene names	Rgs2
Domain Architecture
Description	Regulator of G-protein signaling 2 (RGS2).

RGS7_HUMAN
θ value	8.99809 (rank : 369)	NC score	0.021788 (rank : 499)
Query Neighborhood Hits	375	Target Neighborhood Hits	82	Shared Neighborhood Hits	12
SwissProt Accessions	P49802, Q8TD66, Q8TD67, Q9UNU7, Q9Y6B9	Gene names	RGS7
Domain Architecture
Description	Regulator of G-protein signaling 7 (RGS7).

SMC2_HUMAN
θ value	8.99809 (rank : 370)	NC score	0.035020 (rank : 462)
Query Neighborhood Hits	375	Target Neighborhood Hits	1405	Shared Neighborhood Hits	64
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

SRCA_HUMAN
θ value	8.99809 (rank : 371)	NC score	0.012872 (rank : 527)
Query Neighborhood Hits	375	Target Neighborhood Hits	380	Shared Neighborhood Hits	26
SwissProt Accessions	Q86TD4	Gene names	SRL
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

STK10_HUMAN
θ value	8.99809 (rank : 372)	NC score	0.021922 (rank : 496)
Query Neighborhood Hits	375	Target Neighborhood Hits	1921	Shared Neighborhood Hits	86
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

WNK1_MOUSE
θ value	8.99809 (rank : 373)	NC score	0.009673 (rank : 540)
Query Neighborhood Hits	375	Target Neighborhood Hits	1179	Shared Neighborhood Hits	50
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

ZC3H6_MOUSE
θ value	8.99809 (rank : 374)	NC score	0.009727 (rank : 538)
Query Neighborhood Hits	375	Target Neighborhood Hits	239	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BYK8, Q80UK3, Q8C1H1, Q9D604	Gene names	Zc3h6, Zc3hdc6
Domain Architecture
Description	Zinc finger CCCH domain-containing protein 6.

ZMYM3_MOUSE
θ value	8.99809 (rank : 375)	NC score	0.021416 (rank : 501)
Query Neighborhood Hits	375	Target Neighborhood Hits	177	Shared Neighborhood Hits	18
SwissProt Accessions	Q9JLM4, Q80U17	Gene names	Zmym3, Kiaa0385, Zfp261, Znf261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261) (DXHXS6673E protein).

ABI1_HUMAN
θ value	θ > 10 (rank : 376)	NC score	0.084098 (rank : 298)
Query Neighborhood Hits	375	Target Neighborhood Hits	257	Shared Neighborhood Hits	43
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 377)	NC score	0.088479 (rank : 289)
Query Neighborhood Hits	375	Target Neighborhood Hits	246	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 378)	NC score	0.096617 (rank : 273)
Query Neighborhood Hits	375	Target Neighborhood Hits	350	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 379)	NC score	0.091531 (rank : 281)
Query Neighborhood Hits	375	Target Neighborhood Hits	266	Shared Neighborhood Hits	43
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 380)	NC score	0.077826 (rank : 308)
Query Neighborhood Hits	375	Target Neighborhood Hits	227	Shared Neighborhood Hits	32
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 381)	NC score	0.073404 (rank : 319)
Query Neighborhood Hits	375	Target Neighborhood Hits	227	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AHI1_HUMAN
θ value	θ > 10 (rank : 382)	NC score	0.073392 (rank : 320)
Query Neighborhood Hits	375	Target Neighborhood Hits	537	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 383)	NC score	0.071156 (rank : 327)
Query Neighborhood Hits	375	Target Neighborhood Hits	496	Shared Neighborhood Hits	36
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ANM2_HUMAN
θ value	θ > 10 (rank : 384)	NC score	0.064449 (rank : 352)
Query Neighborhood Hits	375	Target Neighborhood Hits	175	Shared Neighborhood Hits	21
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 385)	NC score	0.060539 (rank : 373)
Query Neighborhood Hits	375	Target Neighborhood Hits	175	Shared Neighborhood Hits	21
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

APXL_HUMAN
θ value	θ > 10 (rank : 386)	NC score	0.146341 (rank : 197)
Query Neighborhood Hits	375	Target Neighborhood Hits	553	Shared Neighborhood Hits	122
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

ARHG7_HUMAN
θ value	θ > 10 (rank : 387)	NC score	0.347322 (rank : 82)
Query Neighborhood Hits	375	Target Neighborhood Hits	347	Shared Neighborhood Hits	86
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
θ value	θ > 10 (rank : 388)	NC score	0.328589 (rank : 89)
Query Neighborhood Hits	375	Target Neighborhood Hits	396	Shared Neighborhood Hits	89
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ASPP1_MOUSE
θ value	θ > 10 (rank : 389)	NC score	0.056432 (rank : 392)
Query Neighborhood Hits	375	Target Neighborhood Hits	1244	Shared Neighborhood Hits	103
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BAIP2_HUMAN
θ value	θ > 10 (rank : 390)	NC score	0.061982 (rank : 367)
Query Neighborhood Hits	375	Target Neighborhood Hits	192	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	θ > 10 (rank : 391)	NC score	0.063586 (rank : 358)
Query Neighborhood Hits	375	Target Neighborhood Hits	185	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BCAR1_HUMAN
θ value	θ > 10 (rank : 392)	NC score	0.062448 (rank : 363)
Query Neighborhood Hits	375	Target Neighborhood Hits	554	Shared Neighborhood Hits	46
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	θ > 10 (rank : 393)	NC score	0.063563 (rank : 359)
Query Neighborhood Hits	375	Target Neighborhood Hits	438	Shared Neighborhood Hits	43
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BI2L1_HUMAN
θ value	θ > 10 (rank : 394)	NC score	0.085740 (rank : 294)
Query Neighborhood Hits	375	Target Neighborhood Hits	156	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 395)	NC score	0.071945 (rank : 324)
Query Neighborhood Hits	375	Target Neighborhood Hits	197	Shared Neighborhood Hits	28
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CASL_HUMAN
θ value	θ > 10 (rank : 396)	NC score	0.057866 (rank : 385)
Query Neighborhood Hits	375	Target Neighborhood Hits	259	Shared Neighborhood Hits	31
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	θ > 10 (rank : 397)	NC score	0.052562 (rank : 410)
Query Neighborhood Hits	375	Target Neighborhood Hits	225	Shared Neighborhood Hits	26
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CD2AP_HUMAN
θ value	θ > 10 (rank : 398)	NC score	0.130799 (rank : 223)
Query Neighborhood Hits	375	Target Neighborhood Hits	315	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 399)	NC score	0.131169 (rank : 222)
Query Neighborhood Hits	375	Target Neighborhood Hits	336	Shared Neighborhood Hits	50
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CNKR2_HUMAN
θ value	θ > 10 (rank : 400)	NC score	0.067179 (rank : 340)
Query Neighborhood Hits	375	Target Neighborhood Hits	197	Shared Neighborhood Hits	57
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	θ > 10 (rank : 401)	NC score	0.067264 (rank : 339)
Query Neighborhood Hits	375	Target Neighborhood Hits	197	Shared Neighborhood Hits	57
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CRKL_HUMAN
θ value	θ > 10 (rank : 402)	NC score	0.094784 (rank : 275)
Query Neighborhood Hits	375	Target Neighborhood Hits	313	Shared Neighborhood Hits	38
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 403)	NC score	0.092190 (rank : 280)
Query Neighborhood Hits	375	Target Neighborhood Hits	307	Shared Neighborhood Hits	36
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 404)	NC score	0.086666 (rank : 292)
Query Neighborhood Hits	375	Target Neighborhood Hits	308	Shared Neighborhood Hits	38
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 405)	NC score	0.089132 (rank : 286)
Query Neighborhood Hits	375	Target Neighborhood Hits	314	Shared Neighborhood Hits	39
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CSKP_HUMAN
θ value	θ > 10 (rank : 406)	NC score	0.051463 (rank : 417)
Query Neighborhood Hits	375	Target Neighborhood Hits	1022	Shared Neighborhood Hits	120
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKP_MOUSE
θ value	θ > 10 (rank : 407)	NC score	0.050416 (rank : 428)
Query Neighborhood Hits	375	Target Neighborhood Hits	1027	Shared Neighborhood Hits	123
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

CT032_HUMAN
θ value	θ > 10 (rank : 408)	NC score	0.056411 (rank : 393)
Query Neighborhood Hits	375	Target Neighborhood Hits	235	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DBNL_HUMAN
θ value	θ > 10 (rank : 409)	NC score	0.070276 (rank : 332)
Query Neighborhood Hits	375	Target Neighborhood Hits	244	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 410)	NC score	0.067787 (rank : 336)
Query Neighborhood Hits	375	Target Neighborhood Hits	306	Shared Neighborhood Hits	34
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DVL1L_HUMAN
θ value	θ > 10 (rank : 411)	NC score	0.130412 (rank : 225)
Query Neighborhood Hits	375	Target Neighborhood Hits	146	Shared Neighborhood Hits	100
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

DVL2_HUMAN
θ value	θ > 10 (rank : 412)	NC score	0.128759 (rank : 227)
Query Neighborhood Hits	375	Target Neighborhood Hits	223	Shared Neighborhood Hits	106
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_MOUSE
θ value	θ > 10 (rank : 413)	NC score	0.129985 (rank : 226)
Query Neighborhood Hits	375	Target Neighborhood Hits	233	Shared Neighborhood Hits	110
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

EEA1_HUMAN
θ value	θ > 10 (rank : 414)	NC score	0.052718 (rank : 408)
Query Neighborhood Hits	375	Target Neighborhood Hits	1796	Shared Neighborhood Hits	80
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

EEA1_MOUSE
θ value	θ > 10 (rank : 415)	NC score	0.051280 (rank : 420)
Query Neighborhood Hits	375	Target Neighborhood Hits	1637	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

EFS_HUMAN
θ value	θ > 10 (rank : 416)	NC score	0.060651 (rank : 372)
Query Neighborhood Hits	375	Target Neighborhood Hits	348	Shared Neighborhood Hits	37
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	θ > 10 (rank : 417)	NC score	0.061842 (rank : 368)
Query Neighborhood Hits	375	Target Neighborhood Hits	389	Shared Neighborhood Hits	45
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

EHD1_HUMAN
θ value	θ > 10 (rank : 418)	NC score	0.051400 (rank : 418)
Query Neighborhood Hits	375	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H4M9, O14611, Q9UNR3	Gene names	EHD1, PAST, PAST1
Domain Architecture
Description	EH-domain-containing protein 1 (Testilin) (hPAST1).

EHD1_MOUSE
θ value	θ > 10 (rank : 419)	NC score	0.051317 (rank : 419)
Query Neighborhood Hits	375	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WVK4	Gene names	Ehd1, Past1
Domain Architecture
Description	EH-domain-containing protein 1 (mPAST1).

EHD2_HUMAN
θ value	θ > 10 (rank : 420)	NC score	0.050759 (rank : 424)
Query Neighborhood Hits	375	Target Neighborhood Hits	29	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NZN4, Q96CB6	Gene names	EHD2
Domain Architecture
Description	EH-domain-containing protein 2.

EHD3_HUMAN
θ value	θ > 10 (rank : 421)	NC score	0.050717 (rank : 425)
Query Neighborhood Hits	375	Target Neighborhood Hits	33	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NZN3, Q8N514, Q9NZB3	Gene names	EHD3, EHD2
Domain Architecture
Description	EH-domain-containing protein 3.

EHD3_MOUSE
θ value	θ > 10 (rank : 422)	NC score	0.050326 (rank : 429)
Query Neighborhood Hits	375	Target Neighborhood Hits	34	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QXY6	Gene names	Ehd3, Ehd2
Domain Architecture
Description	EH-domain-containing protein 3.

EHD4_MOUSE
θ value	θ > 10 (rank : 423)	NC score	0.050112 (rank : 430)
Query Neighborhood Hits	375	Target Neighborhood Hits	40	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EQP2	Gene names	Ehd4, Past2
Domain Architecture
Description	EH-domain-containing protein 4 (mPAST2).

EM55_HUMAN
θ value	θ > 10 (rank : 424)	NC score	0.140630 (rank : 206)
Query Neighborhood Hits	375	Target Neighborhood Hits	228	Shared Neighborhood Hits	111
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

ENAH_HUMAN
θ value	θ > 10 (rank : 425)	NC score	0.052546 (rank : 411)
Query Neighborhood Hits	375	Target Neighborhood Hits	784	Shared Neighborhood Hits	73
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

EP15R_HUMAN
θ value	θ > 10 (rank : 426)	NC score	0.059466 (rank : 377)
Query Neighborhood Hits	375	Target Neighborhood Hits	1083	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

EP15R_MOUSE
θ value	θ > 10 (rank : 427)	NC score	0.063819 (rank : 356)
Query Neighborhood Hits	375	Target Neighborhood Hits	1135	Shared Neighborhood Hits	65
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

EP15_HUMAN
θ value	θ > 10 (rank : 428)	NC score	0.056736 (rank : 389)
Query Neighborhood Hits	375	Target Neighborhood Hits	1021	Shared Neighborhood Hits	51
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP15_MOUSE
θ value	θ > 10 (rank : 429)	NC score	0.057918 (rank : 384)
Query Neighborhood Hits	375	Target Neighborhood Hits	820	Shared Neighborhood Hits	45
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

FGD5_MOUSE
θ value	θ > 10 (rank : 430)	NC score	0.287131 (rank : 116)
Query Neighborhood Hits	375	Target Neighborhood Hits	170	Shared Neighborhood Hits	49
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

GIPC2_HUMAN
θ value	θ > 10 (rank : 431)	NC score	0.071026 (rank : 328)
Query Neighborhood Hits	375	Target Neighborhood Hits	93	Shared Neighborhood Hits	68
SwissProt Accessions	Q8TF65, Q8IYD3, Q9NXS7	Gene names	GIPC2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2.

GRAP2_HUMAN
θ value	θ > 10 (rank : 432)	NC score	0.090721 (rank : 284)
Query Neighborhood Hits	375	Target Neighborhood Hits	304	Shared Neighborhood Hits	38
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 433)	NC score	0.089053 (rank : 287)
Query Neighborhood Hits	375	Target Neighborhood Hits	297	Shared Neighborhood Hits	32
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 434)	NC score	0.112990 (rank : 249)
Query Neighborhood Hits	375	Target Neighborhood Hits	307	Shared Neighborhood Hits	40
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 435)	NC score	0.111941 (rank : 251)
Query Neighborhood Hits	375	Target Neighborhood Hits	309	Shared Neighborhood Hits	40
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 436)	NC score	0.107299 (rank : 257)
Query Neighborhood Hits	375	Target Neighborhood Hits	310	Shared Neighborhood Hits	40
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 437)	NC score	0.107304 (rank : 256)
Query Neighborhood Hits	375	Target Neighborhood Hits	312	Shared Neighborhood Hits	40
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRP3_HUMAN
θ value	θ > 10 (rank : 438)	NC score	0.060459 (rank : 374)
Query Neighborhood Hits	375	Target Neighborhood Hits	131	Shared Neighborhood Hits	17
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

HCLS1_HUMAN
θ value	θ > 10 (rank : 439)	NC score	0.088042 (rank : 290)
Query Neighborhood Hits	375	Target Neighborhood Hits	358	Shared Neighborhood Hits	29
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 440)	NC score	0.090913 (rank : 283)
Query Neighborhood Hits	375	Target Neighborhood Hits	329	Shared Neighborhood Hits	32
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HGS_HUMAN
θ value	θ > 10 (rank : 441)	NC score	0.065423 (rank : 349)
Query Neighborhood Hits	375	Target Neighborhood Hits	517	Shared Neighborhood Hits	44
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	θ > 10 (rank : 442)	NC score	0.068323 (rank : 334)
Query Neighborhood Hits	375	Target Neighborhood Hits	589	Shared Neighborhood Hits	49
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

HTRA1_MOUSE
θ value	θ > 10 (rank : 443)	NC score	0.050010 (rank : 433)
Query Neighborhood Hits	375	Target Neighborhood Hits	140	Shared Neighborhood Hits	46
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

IASPP_HUMAN
θ value	θ > 10 (rank : 444)	NC score	0.052251 (rank : 416)
Query Neighborhood Hits	375	Target Neighborhood Hits	688	Shared Neighborhood Hits	48
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IASPP_MOUSE
θ value	θ > 10 (rank : 445)	NC score	0.051183 (rank : 421)
Query Neighborhood Hits	375	Target Neighborhood Hits	1024	Shared Neighborhood Hits	65
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IL16_MOUSE
θ value	θ > 10 (rank : 446)	NC score	0.226619 (rank : 155)
Query Neighborhood Hits	375	Target Neighborhood Hits	189	Shared Neighborhood Hits	117
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

KGUA_HUMAN
θ value	θ > 10 (rank : 447)	NC score	0.059034 (rank : 379)
Query Neighborhood Hits	375	Target Neighborhood Hits	41	Shared Neighborhood Hits	18
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KGUA_MOUSE
θ value	θ > 10 (rank : 448)	NC score	0.059014 (rank : 380)
Query Neighborhood Hits	375	Target Neighborhood Hits	45	Shared Neighborhood Hits	19
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

LASP1_HUMAN
θ value	θ > 10 (rank : 449)	NC score	0.075612 (rank : 313)
Query Neighborhood Hits	375	Target Neighborhood Hits	293	Shared Neighborhood Hits	36
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	θ > 10 (rank : 450)	NC score	0.073601 (rank : 318)
Query Neighborhood Hits	375	Target Neighborhood Hits	297	Shared Neighborhood Hits	36
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LMO7_HUMAN
θ value	θ > 10 (rank : 451)	NC score	0.105017 (rank : 262)
Query Neighborhood Hits	375	Target Neighborhood Hits	507	Shared Neighborhood Hits	95
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

MPP2_HUMAN
θ value	θ > 10 (rank : 452)	NC score	0.107172 (rank : 258)
Query Neighborhood Hits	375	Target Neighborhood Hits	173	Shared Neighborhood Hits	83
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

MPP2_MOUSE
θ value	θ > 10 (rank : 453)	NC score	0.108553 (rank : 255)
Query Neighborhood Hits	375	Target Neighborhood Hits	189	Shared Neighborhood Hits	86
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

MPP3_HUMAN
θ value	θ > 10 (rank : 454)	NC score	0.148425 (rank : 196)
Query Neighborhood Hits	375	Target Neighborhood Hits	171	Shared Neighborhood Hits	109
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

MPP3_MOUSE
θ value	θ > 10 (rank : 455)	NC score	0.150457 (rank : 194)
Query Neighborhood Hits	375	Target Neighborhood Hits	165	Shared Neighborhood Hits	109
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

MPP6_HUMAN
θ value	θ > 10 (rank : 456)	NC score	0.115321 (rank : 246)
Query Neighborhood Hits	375	Target Neighborhood Hits	180	Shared Neighborhood Hits	76
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
θ value	θ > 10 (rank : 457)	NC score	0.116721 (rank : 245)
Query Neighborhood Hits	375	Target Neighborhood Hits	187	Shared Neighborhood Hits	80
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

NCF1_HUMAN
θ value	θ > 10 (rank : 458)	NC score	0.139859 (rank : 208)
Query Neighborhood Hits	375	Target Neighborhood Hits	198	Shared Neighborhood Hits	35
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 459)	NC score	0.130454 (rank : 224)
Query Neighborhood Hits	375	Target Neighborhood Hits	198	Shared Neighborhood Hits	28
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 460)	NC score	0.122340 (rank : 237)
Query Neighborhood Hits	375	Target Neighborhood Hits	229	Shared Neighborhood Hits	33
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 461)	NC score	0.097011 (rank : 271)
Query Neighborhood Hits	375	Target Neighborhood Hits	161	Shared Neighborhood Hits	17
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 462)	NC score	0.096310 (rank : 274)
Query Neighborhood Hits	375	Target Neighborhood Hits	177	Shared Neighborhood Hits	19
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 463)	NC score	0.119972 (rank : 242)
Query Neighborhood Hits	375	Target Neighborhood Hits	312	Shared Neighborhood Hits	40
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 464)	NC score	0.112489 (rank : 250)
Query Neighborhood Hits	375	Target Neighborhood Hits	310	Shared Neighborhood Hits	31
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NEB1_HUMAN
θ value	θ > 10 (rank : 465)	NC score	0.175580 (rank : 179)
Query Neighborhood Hits	375	Target Neighborhood Hits	829	Shared Neighborhood Hits	140
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

NEB2_HUMAN
θ value	θ > 10 (rank : 466)	NC score	0.167934 (rank : 182)
Query Neighborhood Hits	375	Target Neighborhood Hits	883	Shared Neighborhood Hits	140
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEB2_MOUSE
θ value	θ > 10 (rank : 467)	NC score	0.168013 (rank : 181)
Query Neighborhood Hits	375	Target Neighborhood Hits	889	Shared Neighborhood Hits	146
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEBL_HUMAN
θ value	θ > 10 (rank : 468)	NC score	0.065011 (rank : 350)
Query Neighborhood Hits	375	Target Neighborhood Hits	457	Shared Neighborhood Hits	44
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NEBU_HUMAN
θ value	θ > 10 (rank : 469)	NC score	0.052343 (rank : 414)
Query Neighborhood Hits	375	Target Neighborhood Hits	420	Shared Neighborhood Hits	35
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

NOS1_MOUSE
θ value	θ > 10 (rank : 470)	NC score	0.102073 (rank : 266)
Query Neighborhood Hits	375	Target Neighborhood Hits	155	Shared Neighborhood Hits	93
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

NOXO1_HUMAN
θ value	θ > 10 (rank : 471)	NC score	0.075461 (rank : 314)
Query Neighborhood Hits	375	Target Neighborhood Hits	100	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 472)	NC score	0.075945 (rank : 311)
Query Neighborhood Hits	375	Target Neighborhood Hits	114	Shared Neighborhood Hits	16
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_HUMAN
θ value	θ > 10 (rank : 473)	NC score	0.063437 (rank : 360)
Query Neighborhood Hits	375	Target Neighborhood Hits	288	Shared Neighborhood Hits	34
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 474)	NC score	0.074955 (rank : 315)
Query Neighborhood Hits	375	Target Neighborhood Hits	267	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OSTF1_HUMAN
θ value	θ > 10 (rank : 475)	NC score	0.070472 (rank : 330)
Query Neighborhood Hits	375	Target Neighborhood Hits	466	Shared Neighborhood Hits	40
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 476)	NC score	0.068116 (rank : 335)
Query Neighborhood Hits	375	Target Neighborhood Hits	467	Shared Neighborhood Hits	38
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

P85B_HUMAN
θ value	θ > 10 (rank : 477)	NC score	0.051089 (rank : 422)
Query Neighborhood Hits	375	Target Neighborhood Hits	543	Shared Neighborhood Hits	46
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PACN1_HUMAN
θ value	θ > 10 (rank : 478)	NC score	0.060367 (rank : 376)
Query Neighborhood Hits	375	Target Neighborhood Hits	320	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 479)	NC score	0.058740 (rank : 383)
Query Neighborhood Hits	375	Target Neighborhood Hits	283	Shared Neighborhood Hits	30
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 480)	NC score	0.060407 (rank : 375)
Query Neighborhood Hits	375	Target Neighborhood Hits	339	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 481)	NC score	0.063690 (rank : 357)
Query Neighborhood Hits	375	Target Neighborhood Hits	382	Shared Neighborhood Hits	49
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 482)	NC score	0.061563 (rank : 369)
Query Neighborhood Hits	375	Target Neighborhood Hits	385	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 483)	NC score	0.061160 (rank : 371)
Query Neighborhood Hits	375	Target Neighborhood Hits	380	Shared Neighborhood Hits	40
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PAR6A_HUMAN
θ value	θ > 10 (rank : 484)	NC score	0.121066 (rank : 240)
Query Neighborhood Hits	375	Target Neighborhood Hits	119	Shared Neighborhood Hits	87
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

PAR6A_MOUSE
θ value	θ > 10 (rank : 485)	NC score	0.121582 (rank : 239)
Query Neighborhood Hits	375	Target Neighborhood Hits	115	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

PAR6B_HUMAN
θ value	θ > 10 (rank : 486)	NC score	0.127634 (rank : 230)
Query Neighborhood Hits	375	Target Neighborhood Hits	126	Shared Neighborhood Hits	94
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6B_MOUSE
θ value	θ > 10 (rank : 487)	NC score	0.127969 (rank : 229)
Query Neighborhood Hits	375	Target Neighborhood Hits	128	Shared Neighborhood Hits	96
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6G_HUMAN
θ value	θ > 10 (rank : 488)	NC score	0.128100 (rank : 228)
Query Neighborhood Hits	375	Target Neighborhood Hits	159	Shared Neighborhood Hits	94
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

PAR6G_MOUSE
θ value	θ > 10 (rank : 489)	NC score	0.127524 (rank : 231)
Query Neighborhood Hits	375	Target Neighborhood Hits	121	Shared Neighborhood Hits	91
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

PCLO_MOUSE
θ value	θ > 10 (rank : 490)	NC score	0.103985 (rank : 265)
Query Neighborhood Hits	375	Target Neighborhood Hits	2275	Shared Neighborhood Hits	211
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PCNT_MOUSE
θ value	θ > 10 (rank : 491)	NC score	0.050800 (rank : 423)
Query Neighborhood Hits	375	Target Neighborhood Hits	1207	Shared Neighborhood Hits	67
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

PCQAP_HUMAN
θ value	θ > 10 (rank : 492)	NC score	0.054621 (rank : 400)
Query Neighborhood Hits	375	Target Neighborhood Hits	549	Shared Neighborhood Hits	57
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

PCQAP_MOUSE
θ value	θ > 10 (rank : 493)	NC score	0.053185 (rank : 407)
Query Neighborhood Hits	375	Target Neighborhood Hits	506	Shared Neighborhood Hits	51
SwissProt Accessions	Q924H2	Gene names	Pcqap
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (mPcqap).

PDLI1_MOUSE
θ value	θ > 10 (rank : 494)	NC score	0.140899 (rank : 205)
Query Neighborhood Hits	375	Target Neighborhood Hits	213	Shared Neighborhood Hits	96
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PEX13_HUMAN
θ value	θ > 10 (rank : 495)	NC score	0.055067 (rank : 398)
Query Neighborhood Hits	375	Target Neighborhood Hits	128	Shared Neighborhood Hits	20
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 496)	NC score	0.055988 (rank : 395)
Query Neighborhood Hits	375	Target Neighborhood Hits	126	Shared Neighborhood Hits	16
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PKHA5_HUMAN
θ value	θ > 10 (rank : 497)	NC score	0.056366 (rank : 394)
Query Neighborhood Hits	375	Target Neighborhood Hits	455	Shared Neighborhood Hits	49
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA6_HUMAN
θ value	θ > 10 (rank : 498)	NC score	0.054897 (rank : 399)
Query Neighborhood Hits	375	Target Neighborhood Hits	556	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	θ > 10 (rank : 499)	NC score	0.054386 (rank : 401)
Query Neighborhood Hits	375	Target Neighborhood Hits	591	Shared Neighborhood Hits	54
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHF1_HUMAN
θ value	θ > 10 (rank : 500)	NC score	0.111640 (rank : 253)
Query Neighborhood Hits	375	Target Neighborhood Hits	76	Shared Neighborhood Hits	16
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
θ value	θ > 10 (rank : 501)	NC score	0.111381 (rank : 254)
Query Neighborhood Hits	375	Target Neighborhood Hits	80	Shared Neighborhood Hits	17
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF2_HUMAN
θ value	θ > 10 (rank : 502)	NC score	0.120249 (rank : 241)
Query Neighborhood Hits	375	Target Neighborhood Hits	75	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	θ > 10 (rank : 503)	NC score	0.119594 (rank : 243)
Query Neighborhood Hits	375	Target Neighborhood Hits	77	Shared Neighborhood Hits	18
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHG4_HUMAN
θ value	θ > 10 (rank : 504)	NC score	0.258357 (rank : 140)
Query Neighborhood Hits	375	Target Neighborhood Hits	200	Shared Neighborhood Hits	63
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

PLCG1_HUMAN
θ value	θ > 10 (rank : 505)	NC score	0.078950 (rank : 305)
Query Neighborhood Hits	375	Target Neighborhood Hits	293	Shared Neighborhood Hits	25
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 506)	NC score	0.080774 (rank : 303)
Query Neighborhood Hits	375	Target Neighborhood Hits	314	Shared Neighborhood Hits	25
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 507)	NC score	0.068911 (rank : 333)
Query Neighborhood Hits	375	Target Neighborhood Hits	280	Shared Neighborhood Hits	22
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP1_HUMAN
θ value	θ > 10 (rank : 508)	NC score	0.086116 (rank : 293)
Query Neighborhood Hits	375	Target Neighborhood Hits	389	Shared Neighborhood Hits	50
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 509)	NC score	0.082586 (rank : 302)
Query Neighborhood Hits	375	Target Neighborhood Hits	377	Shared Neighborhood Hits	52
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

RBNS5_HUMAN
θ value	θ > 10 (rank : 510)	NC score	0.064845 (rank : 351)
Query Neighborhood Hits	375	Target Neighborhood Hits	242	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	θ > 10 (rank : 511)	NC score	0.058972 (rank : 382)
Query Neighborhood Hits	375	Target Neighborhood Hits	266	Shared Neighborhood Hits	36
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

REPS1_HUMAN
θ value	θ > 10 (rank : 512)	NC score	0.063176 (rank : 362)
Query Neighborhood Hits	375	Target Neighborhood Hits	205	Shared Neighborhood Hits	19
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS1_MOUSE
θ value	θ > 10 (rank : 513)	NC score	0.065466 (rank : 348)
Query Neighborhood Hits	375	Target Neighborhood Hits	204	Shared Neighborhood Hits	19
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS2_HUMAN
θ value	θ > 10 (rank : 514)	NC score	0.077770 (rank : 309)
Query Neighborhood Hits	375	Target Neighborhood Hits	131	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_MOUSE
θ value	θ > 10 (rank : 515)	NC score	0.079905 (rank : 304)
Query Neighborhood Hits	375	Target Neighborhood Hits	102	Shared Neighborhood Hits	10
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

RHG04_HUMAN
θ value	θ > 10 (rank : 516)	NC score	0.058980 (rank : 381)
Query Neighborhood Hits	375	Target Neighborhood Hits	307	Shared Neighborhood Hits	35
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RIMB1_HUMAN
θ value	θ > 10 (rank : 517)	NC score	0.056616 (rank : 391)
Query Neighborhood Hits	375	Target Neighborhood Hits	1479	Shared Neighborhood Hits	102
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB2_HUMAN
θ value	θ > 10 (rank : 518)	NC score	0.055837 (rank : 396)
Query Neighborhood Hits	375	Target Neighborhood Hits	263	Shared Neighborhood Hits	27
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 519)	NC score	0.056892 (rank : 388)
Query Neighborhood Hits	375	Target Neighborhood Hits	246	Shared Neighborhood Hits	28
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMS1_HUMAN
θ value	θ > 10 (rank : 520)	NC score	0.096962 (rank : 272)
Query Neighborhood Hits	375	Target Neighborhood Hits	437	Shared Neighborhood Hits	119
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

RIMS2_HUMAN
θ value	θ > 10 (rank : 521)	NC score	0.071651 (rank : 325)
Query Neighborhood Hits	375	Target Neighborhood Hits	342	Shared Neighborhood Hits	97
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	θ > 10 (rank : 522)	NC score	0.072500 (rank : 322)
Query Neighborhood Hits	375	Target Neighborhood Hits	376	Shared Neighborhood Hits	95
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RUFY1_HUMAN
θ value	θ > 10 (rank : 523)	NC score	0.054280 (rank : 403)
Query Neighborhood Hits	375	Target Neighborhood Hits	848	Shared Neighborhood Hits	63
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

RUFY1_MOUSE
θ value	θ > 10 (rank : 524)	NC score	0.054324 (rank : 402)
Query Neighborhood Hits	375	Target Neighborhood Hits	765	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY2_HUMAN
θ value	θ > 10 (rank : 525)	NC score	0.056724 (rank : 390)
Query Neighborhood Hits	375	Target Neighborhood Hits	1208	Shared Neighborhood Hits	71
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

RUFY2_MOUSE
θ value	θ > 10 (rank : 526)	NC score	0.055324 (rank : 397)
Query Neighborhood Hits	375	Target Neighborhood Hits	820	Shared Neighborhood Hits	64
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

SDCB2_HUMAN
θ value	θ > 10 (rank : 527)	NC score	0.149862 (rank : 195)
Query Neighborhood Hits	375	Target Neighborhood Hits	121	Shared Neighborhood Hits	108
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

SDCB2_MOUSE
θ value	θ > 10 (rank : 528)	NC score	0.154318 (rank : 191)
Query Neighborhood Hits	375	Target Neighborhood Hits	118	Shared Neighborhood Hits	102
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

SH3G1_HUMAN
θ value	θ > 10 (rank : 529)	NC score	0.077833 (rank : 307)
Query Neighborhood Hits	375	Target Neighborhood Hits	307	Shared Neighborhood Hits	34
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 530)	NC score	0.074034 (rank : 317)
Query Neighborhood Hits	375	Target Neighborhood Hits	291	Shared Neighborhood Hits	33
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 531)	NC score	0.075820 (rank : 312)
Query Neighborhood Hits	375	Target Neighborhood Hits	324	Shared Neighborhood Hits	37
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 532)	NC score	0.074223 (rank : 316)
Query Neighborhood Hits	375	Target Neighborhood Hits	319	Shared Neighborhood Hits	34
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 533)	NC score	0.077252 (rank : 310)
Query Neighborhood Hits	375	Target Neighborhood Hits	222	Shared Neighborhood Hits	26
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 534)	NC score	0.078852 (rank : 306)
Query Neighborhood Hits	375	Target Neighborhood Hits	236	Shared Neighborhood Hits	26
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_HUMAN
θ value	θ > 10 (rank : 535)	NC score	0.139103 (rank : 211)
Query Neighborhood Hits	375	Target Neighborhood Hits	341	Shared Neighborhood Hits	45
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 536)	NC score	0.127404 (rank : 233)
Query Neighborhood Hits	375	Target Neighborhood Hits	332	Shared Neighborhood Hits	40
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SOS1_HUMAN
θ value	θ > 10 (rank : 537)	NC score	0.166420 (rank : 183)
Query Neighborhood Hits	375	Target Neighborhood Hits	274	Shared Neighborhood Hits	50
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	θ > 10 (rank : 538)	NC score	0.157973 (rank : 188)
Query Neighborhood Hits	375	Target Neighborhood Hits	281	Shared Neighborhood Hits	51
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS2_HUMAN
θ value	θ > 10 (rank : 539)	NC score	0.156345 (rank : 190)
Query Neighborhood Hits	375	Target Neighborhood Hits	193	Shared Neighborhood Hits	49
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SPTA1_HUMAN
θ value	θ > 10 (rank : 540)	NC score	0.050688 (rank : 426)
Query Neighborhood Hits	375	Target Neighborhood Hits	748	Shared Neighborhood Hits	63
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA1_MOUSE
θ value	θ > 10 (rank : 541)	NC score	0.052446 (rank : 413)
Query Neighborhood Hits	375	Target Neighborhood Hits	675	Shared Neighborhood Hits	58
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
θ value	θ > 10 (rank : 542)	NC score	0.057224 (rank : 387)
Query Neighborhood Hits	375	Target Neighborhood Hits	888	Shared Neighborhood Hits	63
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SRBS1_HUMAN
θ value	θ > 10 (rank : 543)	NC score	0.117901 (rank : 244)
Query Neighborhood Hits	375	Target Neighborhood Hits	396	Shared Neighborhood Hits	47
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 544)	NC score	0.121605 (rank : 238)
Query Neighborhood Hits	375	Target Neighborhood Hits	409	Shared Neighborhood Hits	38
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 545)	NC score	0.085068 (rank : 297)
Query Neighborhood Hits	375	Target Neighborhood Hits	269	Shared Neighborhood Hits	26
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 546)	NC score	0.085492 (rank : 295)
Query Neighborhood Hits	375	Target Neighborhood Hits	292	Shared Neighborhood Hits	31
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRGP1_HUMAN
θ value	θ > 10 (rank : 547)	NC score	0.050100 (rank : 431)
Query Neighborhood Hits	375	Target Neighborhood Hits	390	Shared Neighborhood Hits	45
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

STAC3_HUMAN
θ value	θ > 10 (rank : 548)	NC score	0.088640 (rank : 288)
Query Neighborhood Hits	375	Target Neighborhood Hits	228	Shared Neighborhood Hits	24
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 549)	NC score	0.090016 (rank : 285)
Query Neighborhood Hits	375	Target Neighborhood Hits	232	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 550)	NC score	0.105655 (rank : 261)
Query Neighborhood Hits	375	Target Neighborhood Hits	276	Shared Neighborhood Hits	32
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 551)	NC score	0.104424 (rank : 263)
Query Neighborhood Hits	375	Target Neighborhood Hits	268	Shared Neighborhood Hits	37
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 552)	NC score	0.099182 (rank : 269)
Query Neighborhood Hits	375	Target Neighborhood Hits	271	Shared Neighborhood Hits	36
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 553)	NC score	0.101614 (rank : 267)
Query Neighborhood Hits	375	Target Neighborhood Hits	273	Shared Neighborhood Hits	42
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 554)	NC score	0.093172 (rank : 278)
Query Neighborhood Hits	375	Target Neighborhood Hits	288	Shared Neighborhood Hits	39
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 555)	NC score	0.094757 (rank : 276)
Query Neighborhood Hits	375	Target Neighborhood Hits	285	Shared Neighborhood Hits	37
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STXB4_HUMAN
θ value	θ > 10 (rank : 556)	NC score	0.144289 (rank : 201)
Query Neighborhood Hits	375	Target Neighborhood Hits	616	Shared Neighborhood Hits	122
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_MOUSE
θ value	θ > 10 (rank : 557)	NC score	0.142259 (rank : 203)
Query Neighborhood Hits	375	Target Neighborhood Hits	629	Shared Neighborhood Hits	118
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

TCGAP_HUMAN
θ value	θ > 10 (rank : 558)	NC score	0.059311 (rank : 378)
Query Neighborhood Hits	375	Target Neighborhood Hits	872	Shared Neighborhood Hits	66
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 559)	NC score	0.066839 (rank : 341)
Query Neighborhood Hits	375	Target Neighborhood Hits	409	Shared Neighborhood Hits	49
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

UN13A_HUMAN
θ value	θ > 10 (rank : 560)	NC score	0.050462 (rank : 427)
Query Neighborhood Hits	375	Target Neighborhood Hits	285	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

VINEX_HUMAN
θ value	θ > 10 (rank : 561)	NC score	0.113178 (rank : 248)
Query Neighborhood Hits	375	Target Neighborhood Hits	270	Shared Neighborhood Hits	33
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 562)	NC score	0.113411 (rank : 247)
Query Neighborhood Hits	375	Target Neighborhood Hits	286	Shared Neighborhood Hits	29
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ZC313_HUMAN
θ value	θ > 10 (rank : 563)	NC score	0.052694 (rank : 409)
Query Neighborhood Hits	375	Target Neighborhood Hits	772	Shared Neighborhood Hits	53
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

ZFY16_HUMAN
θ value	θ > 10 (rank : 564)	NC score	0.065621 (rank : 347)
Query Neighborhood Hits	375	Target Neighborhood Hits	125	Shared Neighborhood Hits	14
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY16_MOUSE
θ value	θ > 10 (rank : 565)	NC score	0.066694 (rank : 343)
Query Neighborhood Hits	375	Target Neighborhood Hits	108	Shared Neighborhood Hits	12
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY21_HUMAN
θ value	θ > 10 (rank : 566)	NC score	0.062172 (rank : 366)
Query Neighborhood Hits	375	Target Neighborhood Hits	72	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_MOUSE
θ value	θ > 10 (rank : 567)	NC score	0.064057 (rank : 354)
Query Neighborhood Hits	375	Target Neighborhood Hits	72	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY28_HUMAN
θ value	θ > 10 (rank : 568)	NC score	0.071156 (rank : 326)
Query Neighborhood Hits	375	Target Neighborhood Hits	152	Shared Neighborhood Hits	16
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV9_HUMAN
θ value	θ > 10 (rank : 569)	NC score	0.070412 (rank : 331)
Query Neighborhood Hits	375	Target Neighborhood Hits	134	Shared Neighborhood Hits	14
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

Hits sorted by NC score

ARHGB_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	375	Target Neighborhood Hits	375	Shared Neighborhood Hits	375
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
NC score	0.922384 (rank : 2)	θ value	4.1775e-114 (rank : 3)
Query Neighborhood Hits	375	Target Neighborhood Hits	351	Shared Neighborhood Hits	208
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
NC score	0.920612 (rank : 3)	θ value	1.09934e-114 (rank : 2)
Query Neighborhood Hits	375	Target Neighborhood Hits	344	Shared Neighborhood Hits	212
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHG1_HUMAN
NC score	0.835875 (rank : 4)	θ value	5.14231e-88 (rank : 5)
Query Neighborhood Hits	375	Target Neighborhood Hits	176	Shared Neighborhood Hits	74
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
NC score	0.813101 (rank : 5)	θ value	1.06975e-93 (rank : 4)
Query Neighborhood Hits	375	Target Neighborhood Hits	266	Shared Neighborhood Hits	78
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

LBC_HUMAN
NC score	0.776583 (rank : 6)	θ value	7.27602e-42 (rank : 6)
Query Neighborhood Hits	375	Target Neighborhood Hits	90	Shared Neighborhood Hits	59
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHG2_MOUSE
NC score	0.769764 (rank : 7)	θ value	1.62093e-41 (rank : 7)
Query Neighborhood Hits	375	Target Neighborhood Hits	120	Shared Neighborhood Hits	63
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG2_HUMAN
NC score	0.754746 (rank : 8)	θ value	4.71619e-41 (rank : 8)
Query Neighborhood Hits	375	Target Neighborhood Hits	142	Shared Neighborhood Hits	62
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG3_MOUSE
NC score	0.673774 (rank : 9)	θ value	6.62687e-19 (rank : 14)
Query Neighborhood Hits	375	Target Neighborhood Hits	85	Shared Neighborhood Hits	65
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG3_HUMAN
NC score	0.673394 (rank : 10)	θ value	1.24977e-17 (rank : 15)
Query Neighborhood Hits	375	Target Neighborhood Hits	82	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

RGNEF_MOUSE
NC score	0.664674 (rank : 11)	θ value	3.05695e-40 (rank : 9)
Query Neighborhood Hits	375	Target Neighborhood Hits	641	Shared Neighborhood Hits	94
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ARHGG_HUMAN
NC score	0.659218 (rank : 12)	θ value	1.86753e-13 (rank : 22)
Query Neighborhood Hits	375	Target Neighborhood Hits	129	Shared Neighborhood Hits	70
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG8_HUMAN
NC score	0.656711 (rank : 13)	θ value	9.26847e-13 (rank : 25)
Query Neighborhood Hits	375	Target Neighborhood Hits	85	Shared Neighborhood Hits	66
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHGG_MOUSE
NC score	0.652265 (rank : 14)	θ value	5.25075e-16 (rank : 17)
Query Neighborhood Hits	375	Target Neighborhood Hits	152	Shared Neighborhood Hits	68
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ECT2_MOUSE
NC score	0.648536 (rank : 15)	θ value	3.07829e-16 (rank : 16)
Query Neighborhood Hits	375	Target Neighborhood Hits	98	Shared Neighborhood Hits	69
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHG8_MOUSE
NC score	0.647378 (rank : 16)	θ value	2.43908e-13 (rank : 23)
Query Neighborhood Hits	375	Target Neighborhood Hits	79	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHG5_HUMAN
NC score	0.641647 (rank : 17)	θ value	5.8054e-15 (rank : 19)
Query Neighborhood Hits	375	Target Neighborhood Hits	172	Shared Neighborhood Hits	72
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

NGEF_HUMAN
NC score	0.634696 (rank : 18)	θ value	7.58209e-15 (rank : 20)
Query Neighborhood Hits	375	Target Neighborhood Hits	166	Shared Neighborhood Hits	69
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ECT2_HUMAN
NC score	0.633899 (rank : 19)	θ value	5.25075e-16 (rank : 18)
Query Neighborhood Hits	375	Target Neighborhood Hits	98	Shared Neighborhood Hits	68
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

NGEF_MOUSE
NC score	0.624691 (rank : 20)	θ value	2.88119e-14 (rank : 21)
Query Neighborhood Hits	375	Target Neighborhood Hits	228	Shared Neighborhood Hits	77
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHGF_HUMAN
NC score	0.616684 (rank : 21)	θ value	4.16044e-13 (rank : 24)
Query Neighborhood Hits	375	Target Neighborhood Hits	214	Shared Neighborhood Hits	80
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

PREX1_HUMAN
NC score	0.593042 (rank : 22)	θ value	2.98157e-11 (rank : 32)
Query Neighborhood Hits	375	Target Neighborhood Hits	177	Shared Neighborhood Hits	105
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

TIAM1_HUMAN
NC score	0.587515 (rank : 23)	θ value	9.59137e-10 (rank : 43)
Query Neighborhood Hits	375	Target Neighborhood Hits	225	Shared Neighborhood Hits	128
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
NC score	0.580528 (rank : 24)	θ value	9.59137e-10 (rank : 44)
Query Neighborhood Hits	375	Target Neighborhood Hits	205	Shared Neighborhood Hits	106
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

FGD3_MOUSE
NC score	0.561079 (rank : 25)	θ value	1.133e-10 (rank : 36)
Query Neighborhood Hits	375	Target Neighborhood Hits	257	Shared Neighborhood Hits	72
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

ARHG4_MOUSE
NC score	0.560119 (rank : 26)	θ value	3.89403e-11 (rank : 33)
Query Neighborhood Hits	375	Target Neighborhood Hits	185	Shared Neighborhood Hits	77
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG9_HUMAN
NC score	0.553191 (rank : 27)	θ value	2.0648e-12 (rank : 27)
Query Neighborhood Hits	375	Target Neighborhood Hits	235	Shared Neighborhood Hits	79
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.552674 (rank : 28)	θ value	3.52202e-12 (rank : 29)
Query Neighborhood Hits	375	Target Neighborhood Hits	234	Shared Neighborhood Hits	79
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

FGD4_HUMAN
NC score	0.540524 (rank : 29)	θ value	1.47974e-10 (rank : 37)
Query Neighborhood Hits	375	Target Neighborhood Hits	219	Shared Neighborhood Hits	78
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
NC score	0.539173 (rank : 30)	θ value	4.59992e-12 (rank : 30)
Query Neighborhood Hits	375	Target Neighborhood Hits	227	Shared Neighborhood Hits	76
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

ARHG4_HUMAN
NC score	0.537172 (rank : 31)	θ value	2.79066e-09 (rank : 47)
Query Neighborhood Hits	375	Target Neighborhood Hits	242	Shared Neighborhood Hits	79
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

FGD3_HUMAN
NC score	0.537140 (rank : 32)	θ value	3.89403e-11 (rank : 34)
Query Neighborhood Hits	375	Target Neighborhood Hits	249	Shared Neighborhood Hits	72
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD2_MOUSE
NC score	0.532583 (rank : 33)	θ value	2.13673e-09 (rank : 46)
Query Neighborhood Hits	375	Target Neighborhood Hits	163	Shared Neighborhood Hits	69
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

PKHG1_HUMAN
NC score	0.531266 (rank : 34)	θ value	1.63604e-09 (rank : 45)
Query Neighborhood Hits	375	Target Neighborhood Hits	174	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

FGD2_HUMAN
NC score	0.525594 (rank : 35)	θ value	4.0297e-08 (rank : 52)
Query Neighborhood Hits	375	Target Neighborhood Hits	151	Shared Neighborhood Hits	71
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD1_MOUSE
NC score	0.518468 (rank : 36)	θ value	2.52405e-10 (rank : 40)
Query Neighborhood Hits	375	Target Neighborhood Hits	387	Shared Neighborhood Hits	87
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_HUMAN
NC score	0.514281 (rank : 37)	θ value	1.9326e-10 (rank : 38)
Query Neighborhood Hits	375	Target Neighborhood Hits	367	Shared Neighborhood Hits	85
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ARHGA_HUMAN
NC score	0.493901 (rank : 38)	θ value	6.87365e-08 (rank : 53)
Query Neighborhood Hits	375	Target Neighborhood Hits	187	Shared Neighborhood Hits	75
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ITSN2_HUMAN
NC score	0.476786 (rank : 39)	θ value	8.63488e-27 (rank : 12)
Query Neighborhood Hits	375	Target Neighborhood Hits	1173	Shared Neighborhood Hits	131
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

MCF2_HUMAN
NC score	0.468477 (rank : 40)	θ value	4.45536e-07 (rank : 56)
Query Neighborhood Hits	375	Target Neighborhood Hits	166	Shared Neighborhood Hits	81
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ARHGA_MOUSE
NC score	0.468000 (rank : 41)	θ value	1.80886e-08 (rank : 50)
Query Neighborhood Hits	375	Target Neighborhood Hits	125	Shared Neighborhood Hits	66
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

VAV2_HUMAN
NC score	0.463033 (rank : 42)	θ value	3.89403e-11 (rank : 35)
Query Neighborhood Hits	375	Target Neighborhood Hits	453	Shared Neighborhood Hits	75
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV_MOUSE
NC score	0.462402 (rank : 43)	θ value	1.74796e-11 (rank : 31)
Query Neighborhood Hits	375	Target Neighborhood Hits	430	Shared Neighborhood Hits	75
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV2_MOUSE
NC score	0.460403 (rank : 44)	θ value	1.9326e-10 (rank : 39)
Query Neighborhood Hits	375	Target Neighborhood Hits	456	Shared Neighborhood Hits	77
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ITSN2_MOUSE
NC score	0.452679 (rank : 45)	θ value	7.30988e-26 (rank : 13)
Query Neighborhood Hits	375	Target Neighborhood Hits	1371	Shared Neighborhood Hits	135
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

VAV_HUMAN
NC score	0.446548 (rank : 46)	θ value	7.34386e-10 (rank : 42)
Query Neighborhood Hits	375	Target Neighborhood Hits	452	Shared Neighborhood Hits	75
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV3_MOUSE
NC score	0.438854 (rank : 47)	θ value	2.69671e-12 (rank : 28)
Query Neighborhood Hits	375	Target Neighborhood Hits	404	Shared Neighborhood Hits	72
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ITSN1_HUMAN
NC score	0.438360 (rank : 48)	θ value	1.02001e-27 (rank : 10)
Query Neighborhood Hits	375	Target Neighborhood Hits	1757	Shared Neighborhood Hits	143
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

FGD6_MOUSE
NC score	0.438212 (rank : 49)	θ value	3.19293e-05 (rank : 79)
Query Neighborhood Hits	375	Target Neighborhood Hits	282	Shared Neighborhood Hits	75
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

ITSN1_MOUSE
NC score	0.437815 (rank : 50)	θ value	1.02001e-27 (rank : 11)
Query Neighborhood Hits	375	Target Neighborhood Hits	1669	Shared Neighborhood Hits	143
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

VAV3_HUMAN
NC score	0.436675 (rank : 51)	θ value	9.26847e-13 (rank : 26)
Query Neighborhood Hits	375	Target Neighborhood Hits	398	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

FGD6_HUMAN
NC score	0.434510 (rank : 52)	θ value	0.000121331 (rank : 92)
Query Neighborhood Hits	375	Target Neighborhood Hits	237	Shared Neighborhood Hits	68
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

MCF2L_MOUSE
NC score	0.427978 (rank : 53)	θ value	0.00665767 (rank : 136)
Query Neighborhood Hits	375	Target Neighborhood Hits	255	Shared Neighborhood Hits	82
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

DNMBP_MOUSE
NC score	0.421547 (rank : 54)	θ value	0.000602161 (rank : 114)
Query Neighborhood Hits	375	Target Neighborhood Hits	435	Shared Neighborhood Hits	92
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_HUMAN
NC score	0.409299 (rank : 55)	θ value	0.000270298 (rank : 100)
Query Neighborhood Hits	375	Target Neighborhood Hits	413	Shared Neighborhood Hits	86
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

PDZD1_MOUSE
NC score	0.406238 (rank : 56)	θ value	8.97725e-08 (rank : 54)
Query Neighborhood Hits	375	Target Neighborhood Hits	191	Shared Neighborhood Hits	150
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PDZD1_HUMAN
NC score	0.391421 (rank : 57)	θ value	1.29631e-06 (rank : 58)
Query Neighborhood Hits	375	Target Neighborhood Hits	190	Shared Neighborhood Hits	151
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

NHERF_MOUSE
NC score	0.390051 (rank : 58)	θ value	8.40245e-06 (rank : 67)
Query Neighborhood Hits	375	Target Neighborhood Hits	195	Shared Neighborhood Hits	151
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHERF_HUMAN
NC score	0.385723 (rank : 59)	θ value	1.29631e-06 (rank : 57)
Query Neighborhood Hits	375	Target Neighborhood Hits	190	Shared Neighborhood Hits	154
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHRF2_HUMAN
NC score	0.385387 (rank : 60)	θ value	4.1701e-05 (rank : 82)
Query Neighborhood Hits	375	Target Neighborhood Hits	197	Shared Neighborhood Hits	161
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

PDZD7_HUMAN
NC score	0.380225 (rank : 61)	θ value	7.1131e-05 (rank : 87)
Query Neighborhood Hits	375	Target Neighborhood Hits	181	Shared Neighborhood Hits	151
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

GNRP_MOUSE
NC score	0.380003 (rank : 62)	θ value	1.69304e-06 (rank : 59)
Query Neighborhood Hits	375	Target Neighborhood Hits	191	Shared Neighborhood Hits	65
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

PDZD3_HUMAN
NC score	0.378293 (rank : 63)	θ value	1.43324e-05 (rank : 71)
Query Neighborhood Hits	375	Target Neighborhood Hits	180	Shared Neighborhood Hits	148
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

USH1C_HUMAN
NC score	0.376316 (rank : 64)	θ value	0.000602161 (rank : 118)
Query Neighborhood Hits	375	Target Neighborhood Hits	327	Shared Neighborhood Hits	170
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

WHRN_MOUSE
NC score	0.376299 (rank : 65)	θ value	2.21117e-06 (rank : 63)
Query Neighborhood Hits	375	Target Neighborhood Hits	412	Shared Neighborhood Hits	180
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

PDZD3_MOUSE
NC score	0.372878 (rank : 66)	θ value	6.43352e-06 (rank : 64)
Query Neighborhood Hits	375	Target Neighborhood Hits	171	Shared Neighborhood Hits	149
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

WHRN_HUMAN
NC score	0.372791 (rank : 67)	θ value	2.44474e-05 (rank : 78)
Query Neighborhood Hits	375	Target Neighborhood Hits	325	Shared Neighborhood Hits	175
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

NHRF2_MOUSE
NC score	0.372265 (rank : 68)	θ value	9.29e-05 (rank : 90)
Query Neighborhood Hits	375	Target Neighborhood Hits	194	Shared Neighborhood Hits	159
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

FARP2_MOUSE
NC score	0.363509 (rank : 69)	θ value	3.64472e-09 (rank : 48)
Query Neighborhood Hits	375	Target Neighborhood Hits	209	Shared Neighborhood Hits	73
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

USH1C_MOUSE
NC score	0.359603 (rank : 70)	θ value	7.1131e-05 (rank : 89)
Query Neighborhood Hits	375	Target Neighborhood Hits	557	Shared Neighborhood Hits	192
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

SYJ2B_HUMAN
NC score	0.357215 (rank : 71)	θ value	0.000786445 (rank : 119)
Query Neighborhood Hits	375	Target Neighborhood Hits	162	Shared Neighborhood Hits	137
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

LIN7A_MOUSE
NC score	0.356629 (rank : 72)	θ value	0.000270298 (rank : 102)
Query Neighborhood Hits	375	Target Neighborhood Hits	193	Shared Neighborhood Hits	158
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

LIN7A_HUMAN
NC score	0.356269 (rank : 73)	θ value	0.000270298 (rank : 101)
Query Neighborhood Hits	375	Target Neighborhood Hits	193	Shared Neighborhood Hits	158
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7B_HUMAN
NC score	0.354984 (rank : 74)	θ value	0.000270298 (rank : 103)
Query Neighborhood Hits	375	Target Neighborhood Hits	200	Shared Neighborhood Hits	156
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

LIN7B_MOUSE
NC score	0.353863 (rank : 75)	θ value	0.00035302 (rank : 107)
Query Neighborhood Hits	375	Target Neighborhood Hits	200	Shared Neighborhood Hits	156
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

GNRP_HUMAN
NC score	0.352634 (rank : 76)	θ value	2.21117e-06 (rank : 62)
Query Neighborhood Hits	375	Target Neighborhood Hits	239	Shared Neighborhood Hits	64
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

PDZ11_HUMAN
NC score	0.351765 (rank : 77)	θ value	0.00228821 (rank : 124)
Query Neighborhood Hits	375	Target Neighborhood Hits	160	Shared Neighborhood Hits	140
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZ11_MOUSE
NC score	0.351458 (rank : 78)	θ value	0.00175202 (rank : 123)
Query Neighborhood Hits	375	Target Neighborhood Hits	154	Shared Neighborhood Hits	133
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

LIN7C_HUMAN
NC score	0.351208 (rank : 79)	θ value	0.00035302 (rank : 108)
Query Neighborhood Hits	375	Target Neighborhood Hits	198	Shared Neighborhood Hits	157
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
NC score	0.351208 (rank : 80)	θ value	0.00035302 (rank : 109)
Query Neighborhood Hits	375	Target Neighborhood Hits	198	Shared Neighborhood Hits	157
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

HAPIP_HUMAN
NC score	0.349133 (rank : 81)	θ value	0.279714 (rank : 199)
Query Neighborhood Hits	375	Target Neighborhood Hits	350	Shared Neighborhood Hits	92
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ARHG7_HUMAN
NC score	0.347322 (rank : 82)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	375	Target Neighborhood Hits	347	Shared Neighborhood Hits	86
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

MAGI1_HUMAN
NC score	0.340713 (rank : 83)	θ value	1.09739e-05 (rank : 68)
Query Neighborhood Hits	375	Target Neighborhood Hits	388	Shared Neighborhood Hits	173
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI1_MOUSE
NC score	0.338315 (rank : 84)	θ value	1.09739e-05 (rank : 69)
Query Neighborhood Hits	375	Target Neighborhood Hits	403	Shared Neighborhood Hits	173
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

FARP2_HUMAN
NC score	0.333041 (rank : 85)	θ value	1.06045e-08 (rank : 49)
Query Neighborhood Hits	375	Target Neighborhood Hits	240	Shared Neighborhood Hits	71
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

INADL_MOUSE
NC score	0.332494 (rank : 86)	θ value	0.00020696 (rank : 97)
Query Neighborhood Hits	375	Target Neighborhood Hits	290	Shared Neighborhood Hits	160
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

MAGI2_HUMAN
NC score	0.330204 (rank : 87)	θ value	1.69304e-06 (rank : 60)
Query Neighborhood Hits	375	Target Neighborhood Hits	373	Shared Neighborhood Hits	162
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

GOPC_MOUSE
NC score	0.329910 (rank : 88)	θ value	2.44474e-05 (rank : 75)
Query Neighborhood Hits	375	Target Neighborhood Hits	323	Shared Neighborhood Hits	157
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

ARHG7_MOUSE
NC score	0.328589 (rank : 89)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	375	Target Neighborhood Hits	396	Shared Neighborhood Hits	89
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

MAGI2_MOUSE
NC score	0.327364 (rank : 90)	θ value	1.69304e-06 (rank : 61)
Query Neighborhood Hits	375	Target Neighborhood Hits	370	Shared Neighborhood Hits	160
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

GOPC_HUMAN
NC score	0.327210 (rank : 91)	θ value	2.44474e-05 (rank : 74)
Query Neighborhood Hits	375	Target Neighborhood Hits	377	Shared Neighborhood Hits	161
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

FARP1_HUMAN
NC score	0.327041 (rank : 92)	θ value	4.0297e-08 (rank : 51)
Query Neighborhood Hits	375	Target Neighborhood Hits	241	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

GRIP2_HUMAN
NC score	0.325356 (rank : 93)	θ value	0.00035302 (rank : 106)
Query Neighborhood Hits	375	Target Neighborhood Hits	256	Shared Neighborhood Hits	162
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

INADL_HUMAN
NC score	0.325183 (rank : 94)	θ value	0.00869519 (rank : 141)
Query Neighborhood Hits	375	Target Neighborhood Hits	260	Shared Neighborhood Hits	154
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

MPDZ_MOUSE
NC score	0.324747 (rank : 95)	θ value	0.00665767 (rank : 137)
Query Neighborhood Hits	375	Target Neighborhood Hits	298	Shared Neighborhood Hits	163
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

GRIP1_HUMAN
NC score	0.324640 (rank : 96)	θ value	2.44474e-05 (rank : 76)
Query Neighborhood Hits	375	Target Neighborhood Hits	231	Shared Neighborhood Hits	164
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

PAR3L_HUMAN
NC score	0.324019 (rank : 97)	θ value	0.000270298 (rank : 104)
Query Neighborhood Hits	375	Target Neighborhood Hits	297	Shared Neighborhood Hits	140
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

RHPN1_MOUSE
NC score	0.323650 (rank : 98)	θ value	4.30538e-10 (rank : 41)
Query Neighborhood Hits	375	Target Neighborhood Hits	154	Shared Neighborhood Hits	128
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

PARD3_HUMAN
NC score	0.322828 (rank : 99)	θ value	4.1701e-05 (rank : 83)
Query Neighborhood Hits	375	Target Neighborhood Hits	312	Shared Neighborhood Hits	151
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

GRIP1_MOUSE
NC score	0.322406 (rank : 100)	θ value	2.44474e-05 (rank : 77)
Query Neighborhood Hits	375	Target Neighborhood Hits	241	Shared Neighborhood Hits	164
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

MPDZ_HUMAN
NC score	0.322319 (rank : 101)	θ value	0.00869519 (rank : 142)
Query Neighborhood Hits	375	Target Neighborhood Hits	261	Shared Neighborhood Hits	164
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

PARD3_MOUSE
NC score	0.321621 (rank : 102)	θ value	5.44631e-05 (rank : 85)
Query Neighborhood Hits	375	Target Neighborhood Hits	290	Shared Neighborhood Hits	150
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

FGD5_HUMAN
NC score	0.320765 (rank : 103)	θ value	0.000121331 (rank : 91)
Query Neighborhood Hits	375	Target Neighborhood Hits	235	Shared Neighborhood Hits	52
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

ARHG6_HUMAN
NC score	0.315368 (rank : 104)	θ value	0.0252991 (rank : 153)
Query Neighborhood Hits	375	Target Neighborhood Hits	376	Shared Neighborhood Hits	70
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

TX1B3_HUMAN
NC score	0.311860 (rank : 105)	θ value	0.813845 (rank : 221)
Query Neighborhood Hits	375	Target Neighborhood Hits	161	Shared Neighborhood Hits	136
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
NC score	0.311793 (rank : 106)	θ value	0.813845 (rank : 222)
Query Neighborhood Hits	375	Target Neighborhood Hits	158	Shared Neighborhood Hits	136
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

PDZD2_HUMAN
NC score	0.306681 (rank : 107)	θ value	0.000461057 (rank : 112)
Query Neighborhood Hits	375	Target Neighborhood Hits	772	Shared Neighborhood Hits	187
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

SHAN2_MOUSE
NC score	0.302165 (rank : 108)	θ value	3.19293e-05 (rank : 80)
Query Neighborhood Hits	375	Target Neighborhood Hits	446	Shared Neighborhood Hits	143
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

RHPN1_HUMAN
NC score	0.300447 (rank : 109)	θ value	2.61198e-07 (rank : 55)
Query Neighborhood Hits	375	Target Neighborhood Hits	158	Shared Neighborhood Hits	123
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

LNX2_MOUSE
NC score	0.300245 (rank : 110)	θ value	8.40245e-06 (rank : 66)
Query Neighborhood Hits	375	Target Neighborhood Hits	407	Shared Neighborhood Hits	151
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

LNX2_HUMAN
NC score	0.298240 (rank : 111)	θ value	8.40245e-06 (rank : 65)
Query Neighborhood Hits	375	Target Neighborhood Hits	389	Shared Neighborhood Hits	150
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

ARHG6_MOUSE
NC score	0.297086 (rank : 112)	θ value	0.279714 (rank : 197)
Query Neighborhood Hits	375	Target Neighborhood Hits	394	Shared Neighborhood Hits	68
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

LNX1_MOUSE
NC score	0.292741 (rank : 113)	θ value	0.000602161 (rank : 116)
Query Neighborhood Hits	375	Target Neighborhood Hits	377	Shared Neighborhood Hits	147
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

DLG3_MOUSE
NC score	0.287976 (rank : 114)	θ value	0.00390308 (rank : 131)
Query Neighborhood Hits	375	Target Neighborhood Hits	274	Shared Neighborhood Hits	155
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

LNX1_HUMAN
NC score	0.287823 (rank : 115)	θ value	0.00509761 (rank : 134)
Query Neighborhood Hits	375	Target Neighborhood Hits	379	Shared Neighborhood Hits	139
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

FGD5_MOUSE
NC score	0.287131 (rank : 116)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	375	Target Neighborhood Hits	170	Shared Neighborhood Hits	49
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

DLG2_HUMAN
NC score	0.287093 (rank : 117)	θ value	0.00298849 (rank : 125)
Query Neighborhood Hits	375	Target Neighborhood Hits	279	Shared Neighborhood Hits	155
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG3_HUMAN
NC score	0.285569 (rank : 118)	θ value	0.00869519 (rank : 140)
Query Neighborhood Hits	375	Target Neighborhood Hits	269	Shared Neighborhood Hits	155
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG4_MOUSE
NC score	0.285106 (rank : 119)	θ value	0.00298849 (rank : 127)
Query Neighborhood Hits	375	Target Neighborhood Hits	282	Shared Neighborhood Hits	155
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_HUMAN
NC score	0.285044 (rank : 120)	θ value	0.00298849 (rank : 126)
Query Neighborhood Hits	375	Target Neighborhood Hits	286	Shared Neighborhood Hits	154
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG2_MOUSE
NC score	0.284602 (rank : 121)	θ value	0.00390308 (rank : 130)
Query Neighborhood Hits	375	Target Neighborhood Hits	271	Shared Neighborhood Hits	154
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

SNTB2_MOUSE
NC score	0.280804 (rank : 122)	θ value	0.00035302 (rank : 111)
Query Neighborhood Hits	375	Target Neighborhood Hits	181	Shared Neighborhood Hits	137
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

DLG1_HUMAN
NC score	0.280451 (rank : 123)	θ value	0.21417 (rank : 192)
Query Neighborhood Hits	375	Target Neighborhood Hits	290	Shared Neighborhood Hits	154
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

DLG1_MOUSE
NC score	0.278953 (rank : 124)	θ value	0.0961366 (rank : 178)
Query Neighborhood Hits	375	Target Neighborhood Hits	285	Shared Neighborhood Hits	151
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

SNTB2_HUMAN
NC score	0.278763 (rank : 125)	θ value	0.000602161 (rank : 117)
Query Neighborhood Hits	375	Target Neighborhood Hits	180	Shared Neighborhood Hits	136
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

ZO3_MOUSE
NC score	0.278140 (rank : 126)	θ value	0.0431538 (rank : 165)
Query Neighborhood Hits	375	Target Neighborhood Hits	224	Shared Neighborhood Hits	154
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

ZO3_HUMAN
NC score	0.275722 (rank : 127)	θ value	0.00102713 (rank : 120)
Query Neighborhood Hits	375	Target Neighborhood Hits	219	Shared Neighborhood Hits	153
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

SNTG2_HUMAN
NC score	0.274784 (rank : 128)	θ value	1.38821 (rank : 240)
Query Neighborhood Hits	375	Target Neighborhood Hits	191	Shared Neighborhood Hits	149
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SHAN2_HUMAN
NC score	0.271353 (rank : 129)	θ value	7.1131e-05 (rank : 88)
Query Neighborhood Hits	375	Target Neighborhood Hits	346	Shared Neighborhood Hits	127
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

BCR_HUMAN
NC score	0.270887 (rank : 130)	θ value	0.00509761 (rank : 132)
Query Neighborhood Hits	375	Target Neighborhood Hits	204	Shared Neighborhood Hits	64
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ZO2_HUMAN
NC score	0.266801 (rank : 131)	θ value	0.000121331 (rank : 93)
Query Neighborhood Hits	375	Target Neighborhood Hits	289	Shared Neighborhood Hits	146
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

GRASP_HUMAN
NC score	0.264632 (rank : 132)	θ value	0.0563607 (rank : 167)
Query Neighborhood Hits	375	Target Neighborhood Hits	147	Shared Neighborhood Hits	117
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

SNTA1_HUMAN
NC score	0.261690 (rank : 133)	θ value	0.0431538 (rank : 164)
Query Neighborhood Hits	375	Target Neighborhood Hits	186	Shared Neighborhood Hits	142
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

ZO2_MOUSE
NC score	0.261304 (rank : 134)	θ value	0.000270298 (rank : 105)
Query Neighborhood Hits	375	Target Neighborhood Hits	296	Shared Neighborhood Hits	138
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

SNTG1_HUMAN
NC score	0.260270 (rank : 135)	θ value	4.03905 (rank : 290)
Query Neighborhood Hits	375	Target Neighborhood Hits	181	Shared Neighborhood Hits	143
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

ZO1_MOUSE
NC score	0.259522 (rank : 136)	θ value	0.00869519 (rank : 143)
Query Neighborhood Hits	375	Target Neighborhood Hits	453	Shared Neighborhood Hits	165
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

SNTG1_MOUSE
NC score	0.259160 (rank : 137)	θ value	3.0926 (rank : 272)
Query Neighborhood Hits	375	Target Neighborhood Hits	179	Shared Neighborhood Hits	143
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

GRASP_MOUSE
NC score	0.258856 (rank : 138)	θ value	0.163984 (rank : 187)
Query Neighborhood Hits	375	Target Neighborhood Hits	131	Shared Neighborhood Hits	117
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

ABR_HUMAN
NC score	0.258425 (rank : 139)	θ value	6.88961 (rank : 318)
Query Neighborhood Hits	375	Target Neighborhood Hits	166	Shared Neighborhood Hits	61
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

PKHG4_HUMAN
NC score	0.258357 (rank : 140)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	375	Target Neighborhood Hits	200	Shared Neighborhood Hits	63
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

SNTA1_MOUSE
NC score	0.253788 (rank : 141)	θ value	0.62314 (rank : 217)
Query Neighborhood Hits	375	Target Neighborhood Hits	170	Shared Neighborhood Hits	138
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

ZO1_HUMAN
NC score	0.252386 (rank : 142)	θ value	0.00665767 (rank : 139)
Query Neighborhood Hits	375	Target Neighborhood Hits	474	Shared Neighborhood Hits	159
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

SNTG2_MOUSE
NC score	0.250935 (rank : 143)	θ value	1.06291 (rank : 232)
Query Neighborhood Hits	375	Target Neighborhood Hits	176	Shared Neighborhood Hits	140
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

RPGF6_HUMAN
NC score	0.248433 (rank : 144)	θ value	0.000158464 (rank : 96)
Query Neighborhood Hits	375	Target Neighborhood Hits	266	Shared Neighborhood Hits	150
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

PSCBP_MOUSE
NC score	0.248101 (rank : 145)	θ value	1.06291 (rank : 229)
Query Neighborhood Hits	375	Target Neighborhood Hits	118	Shared Neighborhood Hits	111
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

PZRN3_MOUSE
NC score	0.247154 (rank : 146)	θ value	0.00509761 (rank : 135)
Query Neighborhood Hits	375	Target Neighborhood Hits	447	Shared Neighborhood Hits	137
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PZRN4_HUMAN
NC score	0.244753 (rank : 147)	θ value	0.0736092 (rank : 175)
Query Neighborhood Hits	375	Target Neighborhood Hits	438	Shared Neighborhood Hits	135
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

PZRN3_HUMAN
NC score	0.242860 (rank : 148)	θ value	0.0330416 (rank : 156)
Query Neighborhood Hits	375	Target Neighborhood Hits	461	Shared Neighborhood Hits	138
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

IL16_HUMAN
NC score	0.242147 (rank : 149)	θ value	4.03905 (rank : 284)
Query Neighborhood Hits	375	Target Neighborhood Hits	207	Shared Neighborhood Hits	122
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

PSCBP_HUMAN
NC score	0.236742 (rank : 150)	θ value	0.62314 (rank : 215)
Query Neighborhood Hits	375	Target Neighborhood Hits	123	Shared Neighborhood Hits	111
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

SYP2L_HUMAN
NC score	0.236169 (rank : 151)	θ value	0.0148317 (rank : 149)
Query Neighborhood Hits	375	Target Neighborhood Hits	400	Shared Neighborhood Hits	126
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

SNTB1_HUMAN
NC score	0.234913 (rank : 152)	θ value	6.88961 (rank : 343)
Query Neighborhood Hits	375	Target Neighborhood Hits	157	Shared Neighborhood Hits	129
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

SNTB1_MOUSE
NC score	0.234652 (rank : 153)	θ value	6.88961 (rank : 344)
Query Neighborhood Hits	375	Target Neighborhood Hits	160	Shared Neighborhood Hits	130
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

LAP4_HUMAN
NC score	0.233156 (rank : 154)	θ value	1.43324e-05 (rank : 70)
Query Neighborhood Hits	375	Target Neighborhood Hits	608	Shared Neighborhood Hits	175
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

IL16_MOUSE
NC score	0.226619 (rank : 155)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	375	Target Neighborhood Hits	189	Shared Neighborhood Hits	117
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

LAP4_MOUSE
NC score	0.221620 (rank : 156)	θ value	0.00509761 (rank : 133)
Query Neighborhood Hits	375	Target Neighborhood Hits	590	Shared Neighborhood Hits	173
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

RPGF2_HUMAN
NC score	0.220985 (rank : 157)	θ value	0.00665767 (rank : 138)
Query Neighborhood Hits	375	Target Neighborhood Hits	242	Shared Neighborhood Hits	141
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

APBA3_HUMAN
NC score	0.220838 (rank : 158)	θ value	0.125558 (rank : 182)
Query Neighborhood Hits	375	Target Neighborhood Hits	201	Shared Neighborhood Hits	122
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

K1849_HUMAN
NC score	0.220503 (rank : 159)	θ value	0.47712 (rank : 209)
Query Neighborhood Hits	375	Target Neighborhood Hits	220	Shared Neighborhood Hits	125
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

APBA1_HUMAN
NC score	0.219393 (rank : 160)	θ value	0.0563607 (rank : 166)
Query Neighborhood Hits	375	Target Neighborhood Hits	325	Shared Neighborhood Hits	132
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

APBA3_MOUSE
NC score	0.216415 (rank : 161)	θ value	0.0252991 (rank : 152)
Query Neighborhood Hits	375	Target Neighborhood Hits	174	Shared Neighborhood Hits	114
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

K1849_MOUSE
NC score	0.215275 (rank : 162)	θ value	0.0148317 (rank : 145)
Query Neighborhood Hits	375	Target Neighborhood Hits	335	Shared Neighborhood Hits	139
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

APBA2_MOUSE
NC score	0.215198 (rank : 163)	θ value	0.0431538 (rank : 160)
Query Neighborhood Hits	375	Target Neighborhood Hits	219	Shared Neighborhood Hits	128
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_HUMAN
NC score	0.214710 (rank : 164)	θ value	0.0431538 (rank : 159)
Query Neighborhood Hits	375	Target Neighborhood Hits	220	Shared Neighborhood Hits	124
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

SDCB1_MOUSE
NC score	0.214088 (rank : 165)	θ value	1.38821 (rank : 239)
Query Neighborhood Hits	375	Target Neighborhood Hits	144	Shared Neighborhood Hits	127
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

PDLI2_MOUSE
NC score	0.213804 (rank : 166)	θ value	0.279714 (rank : 201)
Query Neighborhood Hits	375	Target Neighborhood Hits	220	Shared Neighborhood Hits	119
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

PDLI2_HUMAN
NC score	0.211807 (rank : 167)	θ value	3.0926 (rank : 268)
Query Neighborhood Hits	375	Target Neighborhood Hits	245	Shared Neighborhood Hits	124
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

AFAD_HUMAN
NC score	0.210522 (rank : 168)	θ value	0.365318 (rank : 205)
Query Neighborhood Hits	375	Target Neighborhood Hits	689	Shared Neighborhood Hits	160
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

SHAN1_HUMAN
NC score	0.210022 (rank : 169)	θ value	1.87187e-05 (rank : 72)
Query Neighborhood Hits	375	Target Neighborhood Hits	1041	Shared Neighborhood Hits	186
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SDCB1_HUMAN
NC score	0.209652 (rank : 170)	θ value	1.38821 (rank : 238)
Query Neighborhood Hits	375	Target Neighborhood Hits	150	Shared Neighborhood Hits	129
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

RGS12_HUMAN
NC score	0.206174 (rank : 171)	θ value	4.1701e-05 (rank : 84)
Query Neighborhood Hits	375	Target Neighborhood Hits	333	Shared Neighborhood Hits	144
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

PTN13_HUMAN
NC score	0.204577 (rank : 172)	θ value	0.00134147 (rank : 121)
Query Neighborhood Hits	375	Target Neighborhood Hits	471	Shared Neighborhood Hits	167
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

DLG5_HUMAN
NC score	0.201441 (rank : 173)	θ value	0.279714 (rank : 198)
Query Neighborhood Hits	375	Target Neighborhood Hits	1088	Shared Neighborhood Hits	195
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

SYNP2_MOUSE
NC score	0.200137 (rank : 174)	θ value	0.0330416 (rank : 158)
Query Neighborhood Hits	375	Target Neighborhood Hits	252	Shared Neighborhood Hits	124
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

PTN13_MOUSE
NC score	0.199648 (rank : 175)	θ value	0.00298849 (rank : 128)
Query Neighborhood Hits	375	Target Neighborhood Hits	426	Shared Neighborhood Hits	161
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

SYP2L_MOUSE
NC score	0.193584 (rank : 176)	θ value	0.0563607 (rank : 171)
Query Neighborhood Hits	375	Target Neighborhood Hits	289	Shared Neighborhood Hits	106
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

PDZK4_MOUSE
NC score	0.188900 (rank : 177)	θ value	0.163984 (rank : 190)
Query Neighborhood Hits	375	Target Neighborhood Hits	165	Shared Neighborhood Hits	109
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PDZK4_HUMAN
NC score	0.185121 (rank : 178)	θ value	0.125558 (rank : 183)
Query Neighborhood Hits	375	Target Neighborhood Hits	165	Shared Neighborhood Hits	106
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

NEB1_HUMAN
NC score	0.175580 (rank : 179)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	375	Target Neighborhood Hits	829	Shared Neighborhood Hits	140
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

DUET_HUMAN
NC score	0.168396 (rank : 180)	θ value	2.44474e-05 (rank : 73)
Query Neighborhood Hits	375	Target Neighborhood Hits	1220	Shared Neighborhood Hits	100
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

NEB2_MOUSE
NC score	0.168013 (rank : 181)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	375	Target Neighborhood Hits	889	Shared Neighborhood Hits	146
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEB2_HUMAN
NC score	0.167934 (rank : 182)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	375	Target Neighborhood Hits	883	Shared Neighborhood Hits	140
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

SOS1_HUMAN
NC score	0.166420 (rank : 183)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	375	Target Neighborhood Hits	274	Shared Neighborhood Hits	50
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SYNP2_HUMAN
NC score	0.164437 (rank : 184)	θ value	0.279714 (rank : 204)
Query Neighborhood Hits	375	Target Neighborhood Hits	323	Shared Neighborhood Hits	106
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

MPP4_HUMAN
NC score	0.163066 (rank : 185)	θ value	2.36792 (rank : 254)
Query Neighborhood Hits	375	Target Neighborhood Hits	205	Shared Neighborhood Hits	115
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

PICK1_HUMAN
NC score	0.161035 (rank : 186)	θ value	2.36792 (rank : 256)
Query Neighborhood Hits	375	Target Neighborhood Hits	132	Shared Neighborhood Hits	98
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PICK1_MOUSE
NC score	0.160351 (rank : 187)	θ value	2.36792 (rank : 257)
Query Neighborhood Hits	375	Target Neighborhood Hits	131	Shared Neighborhood Hits	97
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

SOS1_MOUSE
NC score	0.157973 (rank : 188)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	375	Target Neighborhood Hits	281	Shared Neighborhood Hits	51
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

TRIO_HUMAN
NC score	0.156885 (rank : 189)	θ value	0.00298849 (rank : 129)
Query Neighborhood Hits	375	Target Neighborhood Hits	1580	Shared Neighborhood Hits	126
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

SOS2_HUMAN
NC score	0.156345 (rank : 190)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	375	Target Neighborhood Hits	193	Shared Neighborhood Hits	49
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SDCB2_MOUSE
NC score	0.154318 (rank : 191)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	375	Target Neighborhood Hits	118	Shared Neighborhood Hits	102
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

MPP5_HUMAN
NC score	0.154118 (rank : 192)	θ value	3.0926 (rank : 265)
Query Neighborhood Hits	375	Target Neighborhood Hits	231	Shared Neighborhood Hits	114
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
NC score	0.152984 (rank : 193)	θ value	3.0926 (rank : 266)
Query Neighborhood Hits	375	Target Neighborhood Hits	226	Shared Neighborhood Hits	113
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

MPP3_MOUSE
NC score	0.150457 (rank : 194)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	375	Target Neighborhood Hits	165	Shared Neighborhood Hits	109
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

SDCB2_HUMAN
NC score	0.149862 (rank : 195)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	375	Target Neighborhood Hits	121	Shared Neighborhood Hits	108
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

MPP3_HUMAN
NC score	0.148425 (rank : 196)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	375	Target Neighborhood Hits	171	Shared Neighborhood Hits	109
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

APXL_HUMAN
NC score	0.146341 (rank : 197)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	375	Target Neighborhood Hits	553	Shared Neighborhood Hits	122
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

PDLI3_HUMAN
NC score	0.144927 (rank : 198)	θ value	6.88961 (rank : 339)
Query Neighborhood Hits	375	Target Neighborhood Hits	199	Shared Neighborhood Hits	104
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PDLI4_MOUSE
NC score	0.144823 (rank : 199)	θ value	5.27518 (rank : 307)
Query Neighborhood Hits	375	Target Neighborhood Hits	233	Shared Neighborhood Hits	109
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

MPP4_MOUSE
NC score	0.144429 (rank : 200)	θ value	2.36792 (rank : 255)
Query Neighborhood Hits	375	Target Neighborhood Hits	188	Shared Neighborhood Hits	99
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

STXB4_HUMAN
NC score	0.144289 (rank : 201)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	375	Target Neighborhood Hits	616	Shared Neighborhood Hits	122
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

PDLI1_HUMAN
NC score	0.142279 (rank : 202)	θ value	6.88961 (rank : 338)
Query Neighborhood Hits	375	Target Neighborhood Hits	242	Shared Neighborhood Hits	97
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

STXB4_MOUSE
NC score	0.142259 (rank : 203)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	375	Target Neighborhood Hits	629	Shared Neighborhood Hits	118
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

PDLI4_HUMAN
NC score	0.141953 (rank : 204)	θ value	4.03905 (rank : 288)
Query Neighborhood Hits	375	Target Neighborhood Hits	245	Shared Neighborhood Hits	107
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PDLI1_MOUSE
NC score	0.140899 (rank : 205)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	375	Target Neighborhood Hits	213	Shared Neighborhood Hits	96
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

EM55_HUMAN
NC score	0.140630 (rank : 206)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	375	Target Neighborhood Hits	228	Shared Neighborhood Hits	111
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

DVL1_HUMAN
NC score	0.139913 (rank : 207)	θ value	3.0926 (rank : 263)
Query Neighborhood Hits	375	Target Neighborhood Hits	158	Shared Neighborhood Hits	103
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

NCF1_HUMAN
NC score	0.139859 (rank : 208)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	375	Target Neighborhood Hits	198	Shared Neighborhood Hits	35
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

PDLI3_MOUSE
NC score	0.139700 (rank : 209)	θ value	4.03905 (rank : 287)
Query Neighborhood Hits	375	Target Neighborhood Hits	197	Shared Neighborhood Hits	101
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

EM55_MOUSE
NC score	0.139625 (rank : 210)	θ value	8.99809 (rank : 352)
Query Neighborhood Hits	375	Target Neighborhood Hits	221	Shared Neighborhood Hits	108
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

SH3K1_HUMAN
NC score	0.139103 (rank : 211)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	375	Target Neighborhood Hits	341	Shared Neighborhood Hits	45
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

PDLI5_HUMAN
NC score	0.138361 (rank : 212)	θ value	0.0563607 (rank : 170)
Query Neighborhood Hits	375	Target Neighborhood Hits	322	Shared Neighborhood Hits	117
SwissProt Accessions	Q96HC4, O60705	Gene names	PDLIM5, ENH
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

LDB3_MOUSE
NC score	0.138032 (rank : 213)	θ value	0.0148317 (rank : 146)
Query Neighborhood Hits	375	Target Neighborhood Hits	510	Shared Neighborhood Hits	118
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

LDB3_HUMAN
NC score	0.137749 (rank : 214)	θ value	0.0563607 (rank : 169)
Query Neighborhood Hits	375	Target Neighborhood Hits	497	Shared Neighborhood Hits	121
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

DVL3_MOUSE
NC score	0.137408 (rank : 215)	θ value	5.27518 (rank : 299)
Query Neighborhood Hits	375	Target Neighborhood Hits	198	Shared Neighborhood Hits	103
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_HUMAN
NC score	0.137221 (rank : 216)	θ value	5.27518 (rank : 298)
Query Neighborhood Hits	375	Target Neighborhood Hits	194	Shared Neighborhood Hits	102
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

RHPN2_MOUSE
NC score	0.137151 (rank : 217)	θ value	0.0148317 (rank : 148)
Query Neighborhood Hits	375	Target Neighborhood Hits	60	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BWR8, Q9DBN2	Gene names	Rhpn2
Domain Architecture	No domain graphic available
Description	Rhophilin-2 (GTP-Rho-binding protein 2).

DVL1_MOUSE
NC score	0.136701 (rank : 218)	θ value	2.36792 (rank : 249)
Query Neighborhood Hits	375	Target Neighborhood Hits	146	Shared Neighborhood Hits	102
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

PDLI5_MOUSE
NC score	0.134834 (rank : 219)	θ value	0.163984 (rank : 189)
Query Neighborhood Hits	375	Target Neighborhood Hits	287	Shared Neighborhood Hits	111
SwissProt Accessions	Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2	Gene names	Pdlim5, Enh
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

NOS1_HUMAN
NC score	0.131552 (rank : 220)	θ value	0.21417 (rank : 195)
Query Neighborhood Hits	375	Target Neighborhood Hits	218	Shared Neighborhood Hits	118
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

PDLI7_HUMAN
NC score	0.131391 (rank : 221)	θ value	0.0330416 (rank : 155)
Query Neighborhood Hits	375	Target Neighborhood Hits	547	Shared Neighborhood Hits	123
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

CD2AP_MOUSE
NC score	0.131169 (rank : 222)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	375	Target Neighborhood Hits	336	Shared Neighborhood Hits	50
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CD2AP_HUMAN
NC score	0.130799 (rank : 223)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	375	Target Neighborhood Hits	315	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

NCF1_MOUSE
NC score	0.130454 (rank : 224)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	375	Target Neighborhood Hits	198	Shared Neighborhood Hits	28
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

DVL1L_HUMAN
NC score	0.130412 (rank : 225)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	375	Target Neighborhood Hits	146	Shared Neighborhood Hits	100
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

DVL2_MOUSE
NC score	0.129985 (rank : 226)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	375	Target Neighborhood Hits	233	Shared Neighborhood Hits	110
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_HUMAN
NC score	0.128759 (rank : 227)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	375	Target Neighborhood Hits	223	Shared Neighborhood Hits	106
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

PAR6G_HUMAN
NC score	0.128100 (rank : 228)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	375	Target Neighborhood Hits	159	Shared Neighborhood Hits	94
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

PAR6B_MOUSE
NC score	0.127969 (rank : 229)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	375	Target Neighborhood Hits	128	Shared Neighborhood Hits	96
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6B_HUMAN
NC score	0.127634 (rank : 230)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	375	Target Neighborhood Hits	126	Shared Neighborhood Hits	94
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6G_MOUSE
NC score	0.127524 (rank : 231)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	375	Target Neighborhood Hits	121	Shared Neighborhood Hits	91
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

PDZD8_HUMAN
NC score	0.127463 (rank : 232)	θ value	0.0961366 (rank : 179)
Query Neighborhood Hits	375	Target Neighborhood Hits	185	Shared Neighborhood Hits	55
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

SH3K1_MOUSE
NC score	0.127404 (rank : 233)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	375	Target Neighborhood Hits	332	Shared Neighborhood Hits	40
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

LRRC7_HUMAN
NC score	0.125359 (rank : 234)	θ value	0.0193708 (rank : 150)
Query Neighborhood Hits	375	Target Neighborhood Hits	423	Shared Neighborhood Hits	110
SwissProt Accessions	Q96NW7, Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2	Gene names	LRRC7, KIAA1365, LAP1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

LRRC7_MOUSE
NC score	0.124502 (rank : 235)	θ value	0.0193708 (rank : 151)
Query Neighborhood Hits	375	Target Neighborhood Hits	416	Shared Neighborhood Hits	109
SwissProt Accessions	Q80TE7	Gene names	Lrrc7, Kiaa1365, Lap1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

PDLI7_MOUSE
NC score	0.123253 (rank : 236)	θ value	0.21417 (rank : 196)
Query Neighborhood Hits	375	Target Neighborhood Hits	279	Shared Neighborhood Hits	97
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

NCF2_HUMAN
NC score	0.122340 (rank : 237)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	375	Target Neighborhood Hits	229	Shared Neighborhood Hits	33
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

SRBS1_MOUSE
NC score	0.121605 (rank : 238)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	375	Target Neighborhood Hits	409	Shared Neighborhood Hits	38
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

PAR6A_MOUSE
NC score	0.121582 (rank : 239)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	375	Target Neighborhood Hits	115	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

PAR6A_HUMAN
NC score	0.121066 (rank : 240)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	375	Target Neighborhood Hits	119	Shared Neighborhood Hits	87
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

PKHF2_HUMAN
NC score	0.120249 (rank : 241)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	375	Target Neighborhood Hits	75	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

NCK1_HUMAN
NC score	0.119972 (rank : 242)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	375	Target Neighborhood Hits	312	Shared Neighborhood Hits	40
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

PKHF2_MOUSE
NC score	0.119594 (rank : 243)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	375	Target Neighborhood Hits	77	Shared Neighborhood Hits	18
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

SRBS1_HUMAN
NC score	0.117901 (rank : 244)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	375	Target Neighborhood Hits	396	Shared Neighborhood Hits	47
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

MPP6_MOUSE
NC score	0.116721 (rank : 245)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	375	Target Neighborhood Hits	187	Shared Neighborhood Hits	80
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

MPP6_HUMAN
NC score	0.115321 (rank : 246)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	375	Target Neighborhood Hits	180	Shared Neighborhood Hits	76
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

VINEX_MOUSE
NC score	0.113411 (rank : 247)	θ value	θ > 10 (rank : 562)
Query Neighborhood Hits	375	Target Neighborhood Hits	286	Shared Neighborhood Hits	29
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

VINEX_HUMAN
NC score	0.113178 (rank : 248)	θ value	θ > 10 (rank : 561)
Query Neighborhood Hits	375	Target Neighborhood Hits	270	Shared Neighborhood Hits	33
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

GRAP_HUMAN
NC score	0.112990 (rank : 249)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	375	Target Neighborhood Hits	307	Shared Neighborhood Hits	40
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

NCK2_HUMAN
NC score	0.112489 (rank : 250)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	375	Target Neighborhood Hits	310	Shared Neighborhood Hits	31
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

GRAP_MOUSE
NC score	0.111941 (rank : 251)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	375	Target Neighborhood Hits	309	Shared Neighborhood Hits	40
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

LAP2_HUMAN
NC score	0.111655 (rank : 252)	θ value	0.21417 (rank : 193)
Query Neighborhood Hits	375	Target Neighborhood Hits	499	Shared Neighborhood Hits	111
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

PKHF1_HUMAN
NC score	0.111640 (rank : 253)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	375	Target Neighborhood Hits	76	Shared Neighborhood Hits	16
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
NC score	0.111381 (rank : 254)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	375	Target Neighborhood Hits	80	Shared Neighborhood Hits	17
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

MPP2_MOUSE
NC score	0.108553 (rank : 255)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	375	Target Neighborhood Hits	189	Shared Neighborhood Hits	86
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

GRB2_MOUSE
NC score	0.107304 (rank : 256)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	375	Target Neighborhood Hits	312	Shared Neighborhood Hits	40
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRB2_HUMAN
NC score	0.107299 (rank : 257)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	375	Target Neighborhood Hits	310	Shared Neighborhood Hits	40
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

MPP2_HUMAN
NC score	0.107172 (rank : 258)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	375	Target Neighborhood Hits	173	Shared Neighborhood Hits	83
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

LAP2_MOUSE
NC score	0.106740 (rank : 259)	θ value	0.21417 (rank : 194)
Query Neighborhood Hits	375	Target Neighborhood Hits	482	Shared Neighborhood Hits	102
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

RGS3_HUMAN
NC score	0.106258 (rank : 260)	θ value	0.00134147 (rank : 122)
Query Neighborhood Hits	375	Target Neighborhood Hits	1375	Shared Neighborhood Hits	130
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

STAC_HUMAN
NC score	0.105655 (rank : 261)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	375	Target Neighborhood Hits	276	Shared Neighborhood Hits	32
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

LMO7_HUMAN
NC score	0.105017 (rank : 262)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	375	Target Neighborhood Hits	507	Shared Neighborhood Hits	95
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

STAC_MOUSE
NC score	0.104424 (rank : 263)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	375	Target Neighborhood Hits	268	Shared Neighborhood Hits	37
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

RGS3_MOUSE
NC score	0.104032 (rank : 264)	θ value	0.000461057 (rank : 113)
Query Neighborhood Hits	375	Target Neighborhood Hits	1621	Shared Neighborhood Hits	148
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

PCLO_MOUSE
NC score	0.103985 (rank : 265)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	375	Target Neighborhood Hits	2275	Shared Neighborhood Hits	211
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

NOS1_MOUSE
NC score	0.102073 (rank : 266)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	375	Target Neighborhood Hits	155	Shared Neighborhood Hits	93
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

STAM1_MOUSE
NC score	0.101614 (rank : 267)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	375	Target Neighborhood Hits	273	Shared Neighborhood Hits	42
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

RHPN2_HUMAN
NC score	0.099791 (rank : 268)	θ value	0.365318 (rank : 207)
Query Neighborhood Hits	375	Target Neighborhood Hits	42	Shared Neighborhood Hits	22
SwissProt Accessions	Q8IUC4, Q8N3T7, Q8N9D6, Q8NE33, Q96RU1	Gene names	RHPN2
Domain Architecture	No domain graphic available
Description	Rhophilin-2 (GTP-Rho-binding protein 2) (76 kDa RhoB effector protein) (p76RBE).

STAM1_HUMAN
NC score	0.099182 (rank : 269)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	375	Target Neighborhood Hits	271	Shared Neighborhood Hits	36
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

PTN4_HUMAN
NC score	0.098248 (rank : 270)	θ value	0.279714 (rank : 202)
Query Neighborhood Hits	375	Target Neighborhood Hits	303	Shared Neighborhood Hits	115
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

NCF4_HUMAN
NC score	0.097011 (rank : 271)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	375	Target Neighborhood Hits	161	Shared Neighborhood Hits	17
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

RIMS1_HUMAN
NC score	0.096962 (rank : 272)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	375	Target Neighborhood Hits	437	Shared Neighborhood Hits	119
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

ABI2_HUMAN
NC score	0.096617 (rank : 273)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	375	Target Neighborhood Hits	350	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

NCF4_MOUSE
NC score	0.096310 (rank : 274)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	375	Target Neighborhood Hits	177	Shared Neighborhood Hits	19
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

CRKL_HUMAN
NC score	0.094784 (rank : 275)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	375	Target Neighborhood Hits	313	Shared Neighborhood Hits	38
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

STAM2_MOUSE
NC score	0.094757 (rank : 276)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	375	Target Neighborhood Hits	285	Shared Neighborhood Hits	37
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

PTN3_HUMAN
NC score	0.094714 (rank : 277)	θ value	5.27518 (rank : 309)
Query Neighborhood Hits	375	Target Neighborhood Hits	258	Shared Neighborhood Hits	115
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

STAM2_HUMAN
NC score	0.093172 (rank : 278)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	375	Target Neighborhood Hits	288	Shared Neighborhood Hits	39
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

HTRA3_MOUSE
NC score	0.092769 (rank : 279)	θ value	0.0431538 (rank : 162)
Query Neighborhood Hits	375	Target Neighborhood Hits	156	Shared Neighborhood Hits	66
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

CRKL_MOUSE
NC score	0.092190 (rank : 280)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	375	Target Neighborhood Hits	307	Shared Neighborhood Hits	36
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

ABI2_MOUSE
NC score	0.091531 (rank : 281)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	375	Target Neighborhood Hits	266	Shared Neighborhood Hits	43
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

HTRA3_HUMAN
NC score	0.091372 (rank : 282)	θ value	0.0148317 (rank : 144)
Query Neighborhood Hits	375	Target Neighborhood Hits	152	Shared Neighborhood Hits	60
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

HCLS1_MOUSE
NC score	0.090913 (rank : 283)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	375	Target Neighborhood Hits	329	Shared Neighborhood Hits	32
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

GRAP2_HUMAN
NC score	0.090721 (rank : 284)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	375	Target Neighborhood Hits	304	Shared Neighborhood Hits	38
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

STAC3_MOUSE
NC score	0.090016 (rank : 285)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	375	Target Neighborhood Hits	232	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

CRK_MOUSE
NC score	0.089132 (rank : 286)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	375	Target Neighborhood Hits	314	Shared Neighborhood Hits	39
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

GRAP2_MOUSE
NC score	0.089053 (rank : 287)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	375	Target Neighborhood Hits	297	Shared Neighborhood Hits	32
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

STAC3_HUMAN
NC score	0.088640 (rank : 288)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	375	Target Neighborhood Hits	228	Shared Neighborhood Hits	24
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ABI1_MOUSE
NC score	0.088479 (rank : 289)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	375	Target Neighborhood Hits	246	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

HCLS1_HUMAN
NC score	0.088042 (rank : 290)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	375	Target Neighborhood Hits	358	Shared Neighborhood Hits	29
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

GIPC1_MOUSE
NC score	0.086949 (rank : 291)	θ value	8.99809 (rank : 355)
Query Neighborhood Hits	375	Target Neighborhood Hits	92	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Z0G0	Gene names	Gipc1, Gipc, Rgs19ip1, Semcap1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Synectin) (SemaF cytoplasmic domain-associated protein 1) (SEMCAP-1).

CRK_HUMAN
NC score	0.086666 (rank : 292)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	375	Target Neighborhood Hits	308	Shared Neighborhood Hits	38
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

PPIP1_HUMAN
NC score	0.086116 (rank : 293)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	375	Target Neighborhood Hits	389	Shared Neighborhood Hits	50
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

BI2L1_HUMAN
NC score	0.085740 (rank : 294)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	375	Target Neighborhood Hits	156	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

SRC8_MOUSE
NC score	0.085492 (rank : 295)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	375	Target Neighborhood Hits	292	Shared Neighborhood Hits	31
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SI1L2_HUMAN
NC score	0.085182 (rank : 296)	θ value	0.0330416 (rank : 157)
Query Neighborhood Hits	375	Target Neighborhood Hits	131	Shared Neighborhood Hits	51
SwissProt Accessions	Q9P2F8, Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6	Gene names	SIPA1L2, KIAA1389
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

SRC8_HUMAN
NC score	0.085068 (rank : 297)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	375	Target Neighborhood Hits	269	Shared Neighborhood Hits	26
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

ABI1_HUMAN
NC score	0.084098 (rank : 298)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	375	Target Neighborhood Hits	257	Shared Neighborhood Hits	43
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

SI1L2_MOUSE
NC score	0.083799 (rank : 299)	θ value	0.0736092 (rank : 177)
Query Neighborhood Hits	375	Target Neighborhood Hits	124	Shared Neighborhood Hits	53
SwissProt Accessions	Q80TE4, Q6PDY1	Gene names	Sipa1l2, Kiaa0545
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

GIPC1_HUMAN
NC score	0.083632 (rank : 300)	θ value	6.88961 (rank : 328)
Query Neighborhood Hits	375	Target Neighborhood Hits	91	Shared Neighborhood Hits	66
SwissProt Accessions	O14908, Q9BTC9	Gene names	GIPC1, C19orf3, GIPC, RGS19IP1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Tax interaction protein 2) (TIP-2).

PDZD6_HUMAN
NC score	0.083189 (rank : 301)	θ value	0.47712 (rank : 210)
Query Neighborhood Hits	375	Target Neighborhood Hits	81	Shared Neighborhood Hits	44
SwissProt Accessions	Q9ULD6, Q4W5I8, Q86V55	Gene names	PDZD6, KIAA1284, PDZK6
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 6.

PPIP1_MOUSE
NC score	0.082586 (rank : 302)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	375	Target Neighborhood Hits	377	Shared Neighborhood Hits	52
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PLCG1_MOUSE
NC score	0.080774 (rank : 303)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	375	Target Neighborhood Hits	314	Shared Neighborhood Hits	25
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

REPS2_MOUSE
NC score	0.079905 (rank : 304)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	375	Target Neighborhood Hits	102	Shared Neighborhood Hits	10
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

PLCG1_HUMAN
NC score	0.078950 (rank : 305)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	375	Target Neighborhood Hits	293	Shared Neighborhood Hits	25
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SH3G3_MOUSE
NC score	0.078852 (rank : 306)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	375	Target Neighborhood Hits	236	Shared Neighborhood Hits	26
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3G1_HUMAN
NC score	0.077833 (rank : 307)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	375	Target Neighborhood Hits	307	Shared Neighborhood Hits	34
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

ABI3_HUMAN
NC score	0.077826 (rank : 308)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	375	Target Neighborhood Hits	227	Shared Neighborhood Hits	32
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

REPS2_HUMAN
NC score	0.077770 (rank : 309)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	375	Target Neighborhood Hits	131	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

SH3G3_HUMAN
NC score	0.077252 (rank : 310)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	375	Target Neighborhood Hits	222	Shared Neighborhood Hits	26
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

NOXO1_MOUSE
NC score	0.075945 (rank : 311)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	375	Target Neighborhood Hits	114	Shared Neighborhood Hits	16
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

SH3G2_HUMAN
NC score	0.075820 (rank : 312)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	375	Target Neighborhood Hits	324	Shared Neighborhood Hits	37
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

LASP1_HUMAN
NC score	0.075612 (rank : 313)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	375	Target Neighborhood Hits	293	Shared Neighborhood Hits	36
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

NOXO1_HUMAN
NC score	0.075461 (rank : 314)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	375	Target Neighborhood Hits	100	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NPHP1_MOUSE
NC score	0.074955 (rank : 315)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	375	Target Neighborhood Hits	267	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

SH3G2_MOUSE
NC score	0.074223 (rank : 316)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	375	Target Neighborhood Hits	319	Shared Neighborhood Hits	34
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G1_MOUSE
NC score	0.074034 (rank : 317)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	375	Target Neighborhood Hits	291	Shared Neighborhood Hits	33
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

LASP1_MOUSE
NC score	0.073601 (rank : 318)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	375	Target Neighborhood Hits	297	Shared Neighborhood Hits	36
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

ABI3_MOUSE
NC score	0.073404 (rank : 319)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	375	Target Neighborhood Hits	227	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AHI1_HUMAN
NC score	0.073392 (rank : 320)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	375	Target Neighborhood Hits	537	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

SI1L1_HUMAN
NC score	0.072528 (rank : 321)	θ value	0.0961366 (rank : 180)
Query Neighborhood Hits	375	Target Neighborhood Hits	162	Shared Neighborhood Hits	45
SwissProt Accessions	O43166, O95321, Q9UDU4, Q9UNU4	Gene names	SIPA1L1, E6TP1, KIAA0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1 (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6- targeted protein 1).

RIMS2_MOUSE
NC score	0.072500 (rank : 322)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	375	Target Neighborhood Hits	376	Shared Neighborhood Hits	95
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

SI1L1_MOUSE
NC score	0.072361 (rank : 323)	θ value	0.0961366 (rank : 181)
Query Neighborhood Hits	375	Target Neighborhood Hits	189	Shared Neighborhood Hits	52
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

BI2L1_MOUSE
NC score	0.071945 (rank : 324)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	375	Target Neighborhood Hits	197	Shared Neighborhood Hits	28
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

RIMS2_HUMAN
NC score	0.071651 (rank : 325)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	375	Target Neighborhood Hits	342	Shared Neighborhood Hits	97
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

ZFY28_HUMAN
NC score	0.071156 (rank : 326)	θ value	θ > 10 (rank : 568)
Query Neighborhood Hits	375	Target Neighborhood Hits	152	Shared Neighborhood Hits	16
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

AHI1_MOUSE
NC score	0.071156 (rank : 327)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	375	Target Neighborhood Hits	496	Shared Neighborhood Hits	36
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

GIPC2_HUMAN
NC score	0.071026 (rank : 328)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	375	Target Neighborhood Hits	93	Shared Neighborhood Hits	68
SwissProt Accessions	Q8TF65, Q8IYD3, Q9NXS7	Gene names	GIPC2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2.

MY18A_MOUSE
NC score	0.070481 (rank : 329)	θ value	1.06291 (rank : 226)
Query Neighborhood Hits	375	Target Neighborhood Hits	1989	Shared Neighborhood Hits	169
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

OSTF1_HUMAN
NC score	0.070472 (rank : 330)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	375	Target Neighborhood Hits	466	Shared Neighborhood Hits	40
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

ZFYV9_HUMAN
NC score	0.070412 (rank : 331)	θ value	θ > 10 (rank : 569)
Query Neighborhood Hits	375	Target Neighborhood Hits	134	Shared Neighborhood Hits	14
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

DBNL_HUMAN
NC score	0.070276 (rank : 332)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	375	Target Neighborhood Hits	244	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

PLCG2_HUMAN
NC score	0.068911 (rank : 333)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	375	Target Neighborhood Hits	280	Shared Neighborhood Hits	22
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

HGS_MOUSE
NC score	0.068323 (rank : 334)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	375	Target Neighborhood Hits	589	Shared Neighborhood Hits	49
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

OSTF1_MOUSE
NC score	0.068116 (rank : 335)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	375	Target Neighborhood Hits	467	Shared Neighborhood Hits	38
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

DBNL_MOUSE
NC score	0.067787 (rank : 336)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	375	Target Neighborhood Hits	306	Shared Neighborhood Hits	34
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

MY18A_HUMAN
NC score	0.067517 (rank : 337)	θ value	5.27518 (rank : 303)
Query Neighborhood Hits	375	Target Neighborhood Hits	1929	Shared Neighborhood Hits	168
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

CAR11_HUMAN
NC score	0.067496 (rank : 338)	θ value	6.88961 (rank : 321)
Query Neighborhood Hits	375	Target Neighborhood Hits	690	Shared Neighborhood Hits	76
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

CNKR2_MOUSE
NC score	0.067264 (rank : 339)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	375	Target Neighborhood Hits	197	Shared Neighborhood Hits	57
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.067179 (rank : 340)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	375	Target Neighborhood Hits	197	Shared Neighborhood Hits	57
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

TCGAP_MOUSE
NC score	0.066839 (rank : 341)	θ value	θ > 10 (rank : 559)
Query Neighborhood Hits	375	Target Neighborhood Hits	409	Shared Neighborhood Hits	49
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

MAST4_HUMAN
NC score	0.066713 (rank : 342)	θ value	4.1701e-05 (rank : 81)
Query Neighborhood Hits	375	Target Neighborhood Hits	1804	Shared Neighborhood Hits	168
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

ZFY16_MOUSE
NC score	0.066694 (rank : 343)	θ value	θ > 10 (rank : 565)
Query Neighborhood Hits	375	Target Neighborhood Hits	108	Shared Neighborhood Hits	12
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

MAST1_HUMAN
NC score	0.066129 (rank : 344)	θ value	0.000158464 (rank : 94)
Query Neighborhood Hits	375	Target Neighborhood Hits	1146	Shared Neighborhood Hits	144
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST2_HUMAN
NC score	0.065831 (rank : 345)	θ value	7.1131e-05 (rank : 86)
Query Neighborhood Hits	375	Target Neighborhood Hits	1189	Shared Neighborhood Hits	139
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST1_MOUSE
NC score	0.065810 (rank : 346)	θ value	0.000158464 (rank : 95)
Query Neighborhood Hits	375	Target Neighborhood Hits	1123	Shared Neighborhood Hits	136
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

ZFY16_HUMAN
NC score	0.065621 (rank : 347)	θ value	θ > 10 (rank : 564)
Query Neighborhood Hits	375	Target Neighborhood Hits	125	Shared Neighborhood Hits	14
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

REPS1_MOUSE
NC score	0.065466 (rank : 348)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	375	Target Neighborhood Hits	204	Shared Neighborhood Hits	19
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

HGS_HUMAN
NC score	0.065423 (rank : 349)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	375	Target Neighborhood Hits	517	Shared Neighborhood Hits	44
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

NEBL_HUMAN
NC score	0.065011 (rank : 350)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	375	Target Neighborhood Hits	457	Shared Neighborhood Hits	44
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

RBNS5_HUMAN
NC score	0.064845 (rank : 351)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	375	Target Neighborhood Hits	242	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

ANM2_HUMAN
NC score	0.064449 (rank : 352)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	375	Target Neighborhood Hits	175	Shared Neighborhood Hits	21
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

MAST2_MOUSE
NC score	0.064217 (rank : 353)	θ value	0.00020696 (rank : 98)
Query Neighborhood Hits	375	Target Neighborhood Hits	1110	Shared Neighborhood Hits	139
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

ZFY21_MOUSE
NC score	0.064057 (rank : 354)	θ value	θ > 10 (rank : 567)
Query Neighborhood Hits	375	Target Neighborhood Hits	72	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

MAST3_HUMAN
NC score	0.063949 (rank : 355)	θ value	0.00020696 (rank : 99)
Query Neighborhood Hits	375	Target Neighborhood Hits	1128	Shared Neighborhood Hits	142
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

EP15R_MOUSE
NC score	0.063819 (rank : 356)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	375	Target Neighborhood Hits	1135	Shared Neighborhood Hits	65
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

PACN2_MOUSE
NC score	0.063690 (rank : 357)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	375	Target Neighborhood Hits	382	Shared Neighborhood Hits	49
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

BAIP2_MOUSE
NC score	0.063586 (rank : 358)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	375	Target Neighborhood Hits	185	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BCAR1_MOUSE
NC score	0.063563 (rank : 359)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	375	Target Neighborhood Hits	438	Shared Neighborhood Hits	43
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

NPHP1_HUMAN
NC score	0.063437 (rank : 360)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	375	Target Neighborhood Hits	288	Shared Neighborhood Hits	34
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

SI1L3_HUMAN
NC score	0.063300 (rank : 361)	θ value	3.0926 (rank : 271)
Query Neighborhood Hits	375	Target Neighborhood Hits	305	Shared Neighborhood Hits	52
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

REPS1_HUMAN
NC score	0.063176 (rank : 362)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	375	Target Neighborhood Hits	205	Shared Neighborhood Hits	19
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

BCAR1_HUMAN
NC score	0.062448 (rank : 363)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	375	Target Neighborhood Hits	554	Shared Neighborhood Hits	46
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

SRRM2_MOUSE
NC score	0.062228 (rank : 364)	θ value	5.27518 (rank : 314)
Query Neighborhood Hits	375	Target Neighborhood Hits	1470	Shared Neighborhood Hits	107
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

NPBL_MOUSE
NC score	0.062204 (rank : 365)	θ value	0.00035302 (rank : 110)
Query Neighborhood Hits	375	Target Neighborhood Hits	1041	Shared Neighborhood Hits	67
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

ZFY21_HUMAN
NC score	0.062172 (rank : 366)	θ value	θ > 10 (rank : 566)
Query Neighborhood Hits	375	Target Neighborhood Hits	72	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

BAIP2_HUMAN
NC score	0.061982 (rank : 367)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	375	Target Neighborhood Hits	192	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

EFS_MOUSE
NC score	0.061842 (rank : 368)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	375	Target Neighborhood Hits	389	Shared Neighborhood Hits	45
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

PACN3_HUMAN
NC score	0.061563 (rank : 369)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	375	Target Neighborhood Hits	385	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

GRIN1_MOUSE
NC score	0.061446 (rank : 370)	θ value	0.000602161 (rank : 115)
Query Neighborhood Hits	375	Target Neighborhood Hits	337	Shared Neighborhood Hits	26
SwissProt Accessions	Q3UNH4, Q6PGF9, Q9QZY2	Gene names	Gprin1
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

PACN3_MOUSE
NC score	0.061160 (rank : 371)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	375	Target Neighborhood Hits	380	Shared Neighborhood Hits	40
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

EFS_HUMAN
NC score	0.060651 (rank : 372)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	375	Target Neighborhood Hits	348	Shared Neighborhood Hits	37
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

ANM2_MOUSE
NC score	0.060539 (rank : 373)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	375	Target Neighborhood Hits	175	Shared Neighborhood Hits	21
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

GRP3_HUMAN
NC score	0.060459 (rank : 374)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	375	Target Neighborhood Hits	131	Shared Neighborhood Hits	17
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

PACN2_HUMAN
NC score	0.060407 (rank : 375)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	375	Target Neighborhood Hits	339	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN1_HUMAN
NC score	0.060367 (rank : 376)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	375	Target Neighborhood Hits	320	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

EP15R_HUMAN
NC score	0.059466 (rank : 377)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	375	Target Neighborhood Hits	1083	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

TCGAP_HUMAN
NC score	0.059311 (rank : 378)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	375	Target Neighborhood Hits	872	Shared Neighborhood Hits	66
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

KGUA_HUMAN
NC score	0.059034 (rank : 379)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	375	Target Neighborhood Hits	41	Shared Neighborhood Hits	18
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KGUA_MOUSE
NC score	0.059014 (rank : 380)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	375	Target Neighborhood Hits	45	Shared Neighborhood Hits	19
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

RHG04_HUMAN
NC score	0.058980 (rank : 381)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	375	Target Neighborhood Hits	307	Shared Neighborhood Hits	35
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RBNS5_MOUSE
NC score	0.058972 (rank : 382)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	375	Target Neighborhood Hits	266	Shared Neighborhood Hits	36
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

PACN1_MOUSE
NC score	0.058740 (rank : 383)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	375	Target Neighborhood Hits	283	Shared Neighborhood Hits	30
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

EP15_MOUSE
NC score	0.057918 (rank : 384)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	375	Target Neighborhood Hits	820	Shared Neighborhood Hits	45
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

CASL_HUMAN
NC score	0.057866 (rank : 385)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	375	Target Neighborhood Hits	259	Shared Neighborhood Hits	31
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

OBSCN_HUMAN
NC score	0.057835 (rank : 386)	θ value	5.27518 (rank : 306)
Query Neighborhood Hits	375	Target Neighborhood Hits	1931	Shared Neighborhood Hits	108
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

SPTA2_HUMAN
NC score	0.057224 (rank : 387)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	375	Target Neighborhood Hits	888	Shared Neighborhood Hits	63
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

RIMB2_MOUSE
NC score	0.056892 (rank : 388)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	375	Target Neighborhood Hits	246	Shared Neighborhood Hits	28
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

EP15_HUMAN
NC score	0.056736 (rank : 389)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	375	Target Neighborhood Hits	1021	Shared Neighborhood Hits	51
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

RUFY2_HUMAN
NC score	0.056724 (rank : 390)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	375	Target Neighborhood Hits	1208	Shared Neighborhood Hits	71
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

RIMB1_HUMAN
NC score	0.056616 (rank : 391)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	375	Target Neighborhood Hits	1479	Shared Neighborhood Hits	102
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

ASPP1_MOUSE
NC score	0.056432 (rank : 392)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	375	Target Neighborhood Hits	1244	Shared Neighborhood Hits	103
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

CT032_HUMAN
NC score	0.056411 (rank : 393)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	375	Target Neighborhood Hits	235	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

PKHA5_HUMAN
NC score	0.056366 (rank : 394)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	375	Target Neighborhood Hits	455	Shared Neighborhood Hits	49
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PEX13_MOUSE
NC score	0.055988 (rank : 395)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	375	Target Neighborhood Hits	126	Shared Neighborhood Hits	16
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

RIMB2_HUMAN
NC score	0.055837 (rank : 396)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	375	Target Neighborhood Hits	263	Shared Neighborhood Hits	27
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RUFY2_MOUSE
NC score	0.055324 (rank : 397)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	375	Target Neighborhood Hits	820	Shared Neighborhood Hits	64
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

PEX13_HUMAN
NC score	0.055067 (rank : 398)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	375	Target Neighborhood Hits	128	Shared Neighborhood Hits	20
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PKHA6_HUMAN
NC score	0.054897 (rank : 399)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	375	Target Neighborhood Hits	556	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PCQAP_HUMAN
NC score	0.054621 (rank : 400)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	375	Target Neighborhood Hits	549	Shared Neighborhood Hits	57
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

PKHA6_MOUSE
NC score	0.054386 (rank : 401)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	375	Target Neighborhood Hits	591	Shared Neighborhood Hits	54
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

RUFY1_MOUSE
NC score	0.054324 (rank : 402)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	375	Target Neighborhood Hits	765	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY1_HUMAN
NC score	0.054280 (rank : 403)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	375	Target Neighborhood Hits	848	Shared Neighborhood Hits	63
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

HTRA1_HUMAN
NC score	0.053639 (rank : 404)	θ value	8.99809 (rank : 358)
Query Neighborhood Hits	375	Target Neighborhood Hits	155	Shared Neighborhood Hits	48
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

PCNT_HUMAN
NC score	0.053544 (rank : 405)	θ value	0.0736092 (rank : 174)
Query Neighborhood Hits	375	Target Neighborhood Hits	1551	Shared Neighborhood Hits	76
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

PCLO_HUMAN
NC score	0.053279 (rank : 406)	θ value	6.88961 (rank : 337)
Query Neighborhood Hits	375	Target Neighborhood Hits	2046	Shared Neighborhood Hits	132
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PCQAP_MOUSE
NC score	0.053185 (rank : 407)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	375	Target Neighborhood Hits	506	Shared Neighborhood Hits	51
SwissProt Accessions	Q924H2	Gene names	Pcqap
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (mPcqap).

EEA1_HUMAN
NC score	0.052718 (rank : 408)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	375	Target Neighborhood Hits	1796	Shared Neighborhood Hits	80
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

ZC313_HUMAN
NC score	0.052694 (rank : 409)	θ value	θ > 10 (rank : 563)
Query Neighborhood Hits	375	Target Neighborhood Hits	772	Shared Neighborhood Hits	53
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

CASL_MOUSE
NC score	0.052562 (rank : 410)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	375	Target Neighborhood Hits	225	Shared Neighborhood Hits	26
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

ENAH_HUMAN
NC score	0.052546 (rank : 411)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	375	Target Neighborhood Hits	784	Shared Neighborhood Hits	73
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

TCOF_MOUSE
NC score	0.052544 (rank : 412)	θ value	5.27518 (rank : 315)
Query Neighborhood Hits	375	Target Neighborhood Hits	471	Shared Neighborhood Hits	43
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

SPTA1_MOUSE
NC score	0.052446 (rank : 413)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	375	Target Neighborhood Hits	675	Shared Neighborhood Hits	58
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

NEBU_HUMAN
NC score	0.052343 (rank : 414)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	375	Target Neighborhood Hits	420	Shared Neighborhood Hits	35
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

JIP3_HUMAN
NC score	0.052298 (rank : 415)	θ value	2.36792 (rank : 253)
Query Neighborhood Hits	375	Target Neighborhood Hits	1039	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

IASPP_HUMAN
NC score	0.052251 (rank : 416)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	375	Target Neighborhood Hits	688	Shared Neighborhood Hits	48
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

CSKP_HUMAN
NC score	0.051463 (rank : 417)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	375	Target Neighborhood Hits	1022	Shared Neighborhood Hits	120
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

EHD1_HUMAN
NC score	0.051400 (rank : 418)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	375	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H4M9, O14611, Q9UNR3	Gene names	EHD1, PAST, PAST1
Domain Architecture
Description	EH-domain-containing protein 1 (Testilin) (hPAST1).

EHD1_MOUSE
NC score	0.051317 (rank : 419)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	375	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WVK4	Gene names	Ehd1, Past1
Domain Architecture
Description	EH-domain-containing protein 1 (mPAST1).

EEA1_MOUSE
NC score	0.051280 (rank : 420)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	375	Target Neighborhood Hits	1637	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

IASPP_MOUSE
NC score	0.051183 (rank : 421)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	375	Target Neighborhood Hits	1024	Shared Neighborhood Hits	65
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

P85B_HUMAN
NC score	0.051089 (rank : 422)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	375	Target Neighborhood Hits	543	Shared Neighborhood Hits	46
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PCNT_MOUSE
NC score	0.050800 (rank : 423)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	375	Target Neighborhood Hits	1207	Shared Neighborhood Hits	67
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

EHD2_HUMAN
NC score	0.050759 (rank : 424)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	375	Target Neighborhood Hits	29	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NZN4, Q96CB6	Gene names	EHD2
Domain Architecture
Description	EH-domain-containing protein 2.

EHD3_HUMAN
NC score	0.050717 (rank : 425)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	375	Target Neighborhood Hits	33	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NZN3, Q8N514, Q9NZB3	Gene names	EHD3, EHD2
Domain Architecture
Description	EH-domain-containing protein 3.

SPTA1_HUMAN
NC score	0.050688 (rank : 426)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	375	Target Neighborhood Hits	748	Shared Neighborhood Hits	63
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

UN13A_HUMAN
NC score	0.050462 (rank : 427)	θ value	θ > 10 (rank : 560)
Query Neighborhood Hits	375	Target Neighborhood Hits	285	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

CSKP_MOUSE
NC score	0.050416 (rank : 428)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	375	Target Neighborhood Hits	1027	Shared Neighborhood Hits	123
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

EHD3_MOUSE
NC score	0.050326 (rank : 429)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	375	Target Neighborhood Hits	34	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QXY6	Gene names	Ehd3, Ehd2
Domain Architecture
Description	EH-domain-containing protein 3.

EHD4_MOUSE
NC score	0.050112 (rank : 430)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	375	Target Neighborhood Hits	40	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EQP2	Gene names	Ehd4, Past2
Domain Architecture
Description	EH-domain-containing protein 4 (mPAST2).

SRGP1_HUMAN
NC score	0.050100 (rank : 431)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	375	Target Neighborhood Hits	390	Shared Neighborhood Hits	45
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

CP250_HUMAN
NC score	0.050097 (rank : 432)	θ value	1.81305 (rank : 242)
Query Neighborhood Hits	375	Target Neighborhood Hits	1805	Shared Neighborhood Hits	72
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

HTRA1_MOUSE
NC score	0.050010 (rank : 433)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	375	Target Neighborhood Hits	140	Shared Neighborhood Hits	46
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

NIPBL_HUMAN
NC score	0.049874 (rank : 434)	θ value	0.0252991 (rank : 154)
Query Neighborhood Hits	375	Target Neighborhood Hits	1311	Shared Neighborhood Hits	83
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

FLIP1_HUMAN
NC score	0.049617 (rank : 435)	θ value	0.0736092 (rank : 172)
Query Neighborhood Hits	375	Target Neighborhood Hits	1405	Shared Neighborhood Hits	64
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

PRRT3_HUMAN
NC score	0.048362 (rank : 436)	θ value	0.125558 (rank : 184)
Query Neighborhood Hits	375	Target Neighborhood Hits	998	Shared Neighborhood Hits	65
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

GOGB1_HUMAN
NC score	0.047786 (rank : 437)	θ value	0.163984 (rank : 186)
Query Neighborhood Hits	375	Target Neighborhood Hits	2297	Shared Neighborhood Hits	92
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

AKAP9_HUMAN
NC score	0.046356 (rank : 438)	θ value	0.365318 (rank : 206)
Query Neighborhood Hits	375	Target Neighborhood Hits	1710	Shared Neighborhood Hits	74
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

CP250_MOUSE
NC score	0.046265 (rank : 439)	θ value	6.88961 (rank : 325)
Query Neighborhood Hits	375	Target Neighborhood Hits	1583	Shared Neighborhood Hits	69
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

FLIP1_MOUSE
NC score	0.046184 (rank : 440)	θ value	0.0431538 (rank : 161)
Query Neighborhood Hits	375	Target Neighborhood Hits	1176	Shared Neighborhood Hits	64
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

NCOA6_HUMAN
NC score	0.045973 (rank : 441)	θ value	0.279714 (rank : 200)
Query Neighborhood Hits	375	Target Neighborhood Hits	1202	Shared Neighborhood Hits	75
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

NACAM_MOUSE
NC score	0.044552 (rank : 442)	θ value	1.06291 (rank : 228)
Query Neighborhood Hits	375	Target Neighborhood Hits	1866	Shared Neighborhood Hits	110
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

SHC2_HUMAN
NC score	0.043587 (rank : 443)	θ value	0.0736092 (rank : 176)
Query Neighborhood Hits	375	Target Neighborhood Hits	170	Shared Neighborhood Hits	14
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

LSP1_MOUSE
NC score	0.043380 (rank : 444)	θ value	0.0736092 (rank : 173)
Query Neighborhood Hits	375	Target Neighborhood Hits	125	Shared Neighborhood Hits	10
SwissProt Accessions	P19973, P97339, Q04950, Q62022, Q62023, Q62024, Q8CD28, Q99L65	Gene names	Lsp1, Pp52, S37, Wp34
Domain Architecture
Description	Lymphocyte-specific protein 1 (Protein pp52) (52 kDa phosphoprotein) (Lymphocyte-specific antigen WP34) (S37 protein).

LUZP1_MOUSE
NC score	0.042298 (rank : 445)	θ value	6.88961 (rank : 330)
Query Neighborhood Hits	375	Target Neighborhood Hits	940	Shared Neighborhood Hits	55
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

TXLNA_MOUSE
NC score	0.041747 (rank : 446)	θ value	3.0926 (rank : 277)
Query Neighborhood Hits	375	Target Neighborhood Hits	846	Shared Neighborhood Hits	54
SwissProt Accessions	Q6PAM1, Q6P1E5	Gene names	Txlna, Txln
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

SYNE1_HUMAN
NC score	0.040409 (rank : 447)	θ value	0.62314 (rank : 218)
Query Neighborhood Hits	375	Target Neighborhood Hits	1484	Shared Neighborhood Hits	72
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

CCD46_MOUSE
NC score	0.040374 (rank : 448)	θ value	8.99809 (rank : 349)
Query Neighborhood Hits	375	Target Neighborhood Hits	1405	Shared Neighborhood Hits	68
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

TXLNB_HUMAN
NC score	0.040302 (rank : 449)	θ value	0.813845 (rank : 223)
Query Neighborhood Hits	375	Target Neighborhood Hits	912	Shared Neighborhood Hits	77
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

TXLNA_HUMAN
NC score	0.040225 (rank : 450)	θ value	3.0926 (rank : 276)
Query Neighborhood Hits	375	Target Neighborhood Hits	982	Shared Neighborhood Hits	67
SwissProt Accessions	P40222, Q66K62, Q86T54, Q86T85, Q86T86, Q86Y86, Q86YW3, Q8N2Y3	Gene names	TXLNA, TXLN
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

IFT74_HUMAN
NC score	0.039747 (rank : 451)	θ value	3.0926 (rank : 264)
Query Neighborhood Hits	375	Target Neighborhood Hits	949	Shared Neighborhood Hits	48
SwissProt Accessions	Q96LB3, Q6PGQ8, Q9H643, Q9H8G7	Gene names	IFT74, CCDC2, CMG1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

RB6I2_MOUSE
NC score	0.039614 (rank : 452)	θ value	8.99809 (rank : 367)
Query Neighborhood Hits	375	Target Neighborhood Hits	1433	Shared Neighborhood Hits	65
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

PHLB1_HUMAN
NC score	0.039354 (rank : 453)	θ value	1.81305 (rank : 244)
Query Neighborhood Hits	375	Target Neighborhood Hits	1038	Shared Neighborhood Hits	78
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

TXLNB_MOUSE
NC score	0.039045 (rank : 454)	θ value	0.62314 (rank : 219)
Query Neighborhood Hits	375	Target Neighborhood Hits	640	Shared Neighborhood Hits	52
SwissProt Accessions	Q8VBT1, Q3UVB8, Q8BUK2	Gene names	Txlnb, Mdp77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77).

RB6I2_HUMAN
NC score	0.038714 (rank : 455)	θ value	6.88961 (rank : 341)
Query Neighborhood Hits	375	Target Neighborhood Hits	1584	Shared Neighborhood Hits	72
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

MAP1A_HUMAN
NC score	0.038018 (rank : 456)	θ value	8.99809 (rank : 361)
Query Neighborhood Hits	375	Target Neighborhood Hits	1626	Shared Neighborhood Hits	95
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

REST_HUMAN
NC score	0.037858 (rank : 457)	θ value	0.62314 (rank : 216)
Query Neighborhood Hits	375	Target Neighborhood Hits	1605	Shared Neighborhood Hits	67
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

RGS14_MOUSE
NC score	0.036627 (rank : 458)	θ value	1.06291 (rank : 230)
Query Neighborhood Hits	375	Target Neighborhood Hits	55	Shared Neighborhood Hits	9
SwissProt Accessions	P97492, Q9DCD1	Gene names	Rgs14
Domain Architecture
Description	Regulator of G-protein signaling 14 (RGS14) (RAP1/RAP2-interacting protein).

CK5P2_MOUSE
NC score	0.036206 (rank : 459)	θ value	1.81305 (rank : 241)
Query Neighborhood Hits	375	Target Neighborhood Hits	1151	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

NEST_HUMAN
NC score	0.035293 (rank : 460)	θ value	8.99809 (rank : 362)
Query Neighborhood Hits	375	Target Neighborhood Hits	1305	Shared Neighborhood Hits	80
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

MRCKB_MOUSE
NC score	0.035134 (rank : 461)	θ value	3.0926 (rank : 267)
Query Neighborhood Hits	375	Target Neighborhood Hits	2180	Shared Neighborhood Hits	92
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

SMC2_HUMAN
NC score	0.035020 (rank : 462)	θ value	8.99809 (rank : 370)
Query Neighborhood Hits	375	Target Neighborhood Hits	1405	Shared Neighborhood Hits	64
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

RGS14_HUMAN
NC score	0.034327 (rank : 463)	θ value	6.88961 (rank : 342)
Query Neighborhood Hits	375	Target Neighborhood Hits	77	Shared Neighborhood Hits	12
SwissProt Accessions	O43566, O43565, Q8TD62	Gene names	RGS14
Domain Architecture
Description	Regulator of G-protein signaling 14 (RGS14).

MACF4_HUMAN
NC score	0.034145 (rank : 464)	θ value	6.88961 (rank : 332)
Query Neighborhood Hits	375	Target Neighborhood Hits	1321	Shared Neighborhood Hits	68
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

ARI3A_HUMAN
NC score	0.033937 (rank : 465)	θ value	0.163984 (rank : 185)
Query Neighborhood Hits	375	Target Neighborhood Hits	80	Shared Neighborhood Hits	12
SwissProt Accessions	Q99856, Q8IZA7	Gene names	ARID3A, DRIL1, DRX, E2FBP1
Domain Architecture
Description	AT-rich interactive domain-containing protein 3A (ARID domain- containing protein 3A) (B-cell regulator of IgH transcription) (Bright) (E2F-binding protein 1).

GUAA_HUMAN
NC score	0.033338 (rank : 466)	θ value	0.62314 (rank : 214)
Query Neighborhood Hits	375	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P49915	Gene names	GMPS
Domain Architecture
Description	GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (Glutamine amidotransferase) (GMP synthetase).

SON_HUMAN
NC score	0.033209 (rank : 467)	θ value	0.47712 (rank : 211)
Query Neighborhood Hits	375	Target Neighborhood Hits	1568	Shared Neighborhood Hits	92
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

JIP4_HUMAN
NC score	0.032864 (rank : 468)	θ value	6.88961 (rank : 329)
Query Neighborhood Hits	375	Target Neighborhood Hits	585	Shared Neighborhood Hits	42
SwissProt Accessions	O60271, O60905, Q3KQU8, Q3MKM7, Q86WC7, Q86WC8, Q8IZX7, Q96II0, Q9H811	Gene names	SPAG9, HSS, KIAA0516, MAPK8IP4, SYD1
Domain Architecture	No domain graphic available
Description	C-jun-amino-terminal kinase-interacting protein 4 (JNK-interacting protein 4) (JIP-4) (JNK-associated leucine-zipper protein) (JLP) (Sperm-associated antigen 9) (Mitogen-activated protein kinase 8- interacting protein 4) (Human lung cancer protein 6) (HLC-6) (Proliferation-inducing protein 6) (Sperm-specific protein) (Sperm surface protein) (Protein highly expressed in testis) (PHET) (Sunday driver 1).

PRP1_HUMAN
NC score	0.032827 (rank : 469)	θ value	8.99809 (rank : 366)
Query Neighborhood Hits	375	Target Neighborhood Hits	385	Shared Neighborhood Hits	41
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

AKAP2_MOUSE
NC score	0.032826 (rank : 470)	θ value	5.27518 (rank : 294)
Query Neighborhood Hits	375	Target Neighborhood Hits	385	Shared Neighborhood Hits	42
SwissProt Accessions	O54931, O54932, O54933	Gene names	Akap2
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2) (AKAP expressed in kidney and lung) (AKAP-KL).

T22D4_HUMAN
NC score	0.032589 (rank : 471)	θ value	0.47712 (rank : 212)
Query Neighborhood Hits	375	Target Neighborhood Hits	403	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y3Q8	Gene names	TSC22D4, TILZ2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1).

PRRT3_MOUSE
NC score	0.032427 (rank : 472)	θ value	5.27518 (rank : 308)
Query Neighborhood Hits	375	Target Neighborhood Hits	162	Shared Neighborhood Hits	17
SwissProt Accessions	Q6PE13	Gene names	Prrt3
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

BCL9_MOUSE
NC score	0.031880 (rank : 473)	θ value	5.27518 (rank : 296)
Query Neighborhood Hits	375	Target Neighborhood Hits	770	Shared Neighborhood Hits	58
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

CTRO_MOUSE
NC score	0.031824 (rank : 474)	θ value	4.03905 (rank : 282)
Query Neighborhood Hits	375	Target Neighborhood Hits	2344	Shared Neighborhood Hits	91
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

SDCG8_MOUSE
NC score	0.031758 (rank : 475)	θ value	1.06291 (rank : 231)
Query Neighborhood Hits	375	Target Neighborhood Hits	886	Shared Neighborhood Hits	50
SwissProt Accessions	Q80UF4	Gene names	Sdccag8, Cccap
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (mCCCAP).

BCL9_HUMAN
NC score	0.030764 (rank : 476)	θ value	8.99809 (rank : 348)
Query Neighborhood Hits	375	Target Neighborhood Hits	1008	Shared Neighborhood Hits	70
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

MACF1_HUMAN
NC score	0.029842 (rank : 477)	θ value	6.88961 (rank : 331)
Query Neighborhood Hits	375	Target Neighborhood Hits	1341	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

DSPP_MOUSE
NC score	0.027738 (rank : 478)	θ value	3.0926 (rank : 262)
Query Neighborhood Hits	375	Target Neighborhood Hits	491	Shared Neighborhood Hits	28
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

TF3C1_HUMAN
NC score	0.026458 (rank : 479)	θ value	0.47712 (rank : 213)
Query Neighborhood Hits	375	Target Neighborhood Hits	88	Shared Neighborhood Hits	8
SwissProt Accessions	Q12789, Q12838, Q9Y4W9	Gene names	GTF3C1
Domain Architecture	No domain graphic available
Description	General transcription factor 3C polypeptide 1 (Transcription factor IIIC-subunit alpha) (TF3C-alpha) (TFIIIC 220 kDa subunit) (TFIIIC220) (TFIIIC box B-binding subunit).

PHF20_HUMAN
NC score	0.026018 (rank : 480)	θ value	0.163984 (rank : 191)
Query Neighborhood Hits	375	Target Neighborhood Hits	394	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BVI0, Q5JWY9, Q9BWV4, Q9BXA3, Q9BZW3, Q9H421, Q9H4J6, Q9NZ22	Gene names	PHF20, C20orf104, GLEA2, HCA58, NZF, TZP
Domain Architecture
Description	PHD finger protein 20 (Hepatocellular carcinoma-associated antigen 58) (Glioma-expressed antigen 2) (Transcription factor TZP) (Novel zinc finger protein).

STK10_MOUSE
NC score	0.025671 (rank : 481)	θ value	2.36792 (rank : 259)
Query Neighborhood Hits	375	Target Neighborhood Hits	2132	Shared Neighborhood Hits	87
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

MACF1_MOUSE
NC score	0.025515 (rank : 482)	θ value	1.06291 (rank : 225)
Query Neighborhood Hits	375	Target Neighborhood Hits	1313	Shared Neighborhood Hits	62
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

RASA1_HUMAN
NC score	0.025446 (rank : 483)	θ value	3.0926 (rank : 269)
Query Neighborhood Hits	375	Target Neighborhood Hits	258	Shared Neighborhood Hits	16
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

MYH14_MOUSE
NC score	0.025331 (rank : 484)	θ value	0.163984 (rank : 188)
Query Neighborhood Hits	375	Target Neighborhood Hits	1225	Shared Neighborhood Hits	58
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

LIMK1_HUMAN
NC score	0.025083 (rank : 485)	θ value	0.0431538 (rank : 163)
Query Neighborhood Hits	375	Target Neighborhood Hits	1005	Shared Neighborhood Hits	86
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

RGS1_MOUSE
NC score	0.025042 (rank : 486)	θ value	5.27518 (rank : 310)
Query Neighborhood Hits	375	Target Neighborhood Hits	60	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JL25, Q3TBD1, Q3TC18, Q3TD56	Gene names	Rgs1
Domain Architecture
Description	Regulator of G-protein signaling 1 (RGS1).

TTDN1_MOUSE
NC score	0.025035 (rank : 487)	θ value	3.0926 (rank : 274)
Query Neighborhood Hits	375	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D011	Gene names	Ttdn1
Domain Architecture	No domain graphic available
Description	TTD non-photosensitive 1 protein homolog.

LIMK1_MOUSE
NC score	0.025026 (rank : 488)	θ value	0.0148317 (rank : 147)
Query Neighborhood Hits	375	Target Neighborhood Hits	1008	Shared Neighborhood Hits	85
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

ZN385_HUMAN
NC score	0.024931 (rank : 489)	θ value	1.81305 (rank : 246)
Query Neighborhood Hits	375	Target Neighborhood Hits	614	Shared Neighborhood Hits	40
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

FA47B_HUMAN
NC score	0.024527 (rank : 490)	θ value	1.38821 (rank : 235)
Query Neighborhood Hits	375	Target Neighborhood Hits	431	Shared Neighborhood Hits	24
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

RGS2_MOUSE
NC score	0.024484 (rank : 491)	θ value	8.99809 (rank : 368)
Query Neighborhood Hits	375	Target Neighborhood Hits	52	Shared Neighborhood Hits	9
SwissProt Accessions	O08849, Q544S7, Q91WX1, Q9JL24	Gene names	Rgs2
Domain Architecture
Description	Regulator of G-protein signaling 2 (RGS2).

GTSE1_MOUSE
NC score	0.023925 (rank : 492)	θ value	5.27518 (rank : 300)
Query Neighborhood Hits	375	Target Neighborhood Hits	245	Shared Neighborhood Hits	24
SwissProt Accessions	Q8R080, O89015, Q9CSG9	Gene names	Gtse1, B99
Domain Architecture	No domain graphic available
Description	G2 and S phase expressed protein 1 (Gtse-1) (B99 protein).

MYRIP_MOUSE
NC score	0.022926 (rank : 493)	θ value	5.27518 (rank : 304)
Query Neighborhood Hits	375	Target Neighborhood Hits	207	Shared Neighborhood Hits	19
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

SLK_MOUSE
NC score	0.022085 (rank : 494)	θ value	0.279714 (rank : 203)
Query Neighborhood Hits	375	Target Neighborhood Hits	1798	Shared Neighborhood Hits	76
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

MECP2_HUMAN
NC score	0.021971 (rank : 495)	θ value	4.03905 (rank : 285)
Query Neighborhood Hits	375	Target Neighborhood Hits	92	Shared Neighborhood Hits	14
SwissProt Accessions	P51608, O15233	Gene names	MECP2
Domain Architecture
Description	Methyl-CpG-binding protein 2 (MeCP-2 protein) (MeCP2).

STK10_HUMAN
NC score	0.021922 (rank : 496)	θ value	8.99809 (rank : 372)
Query Neighborhood Hits	375	Target Neighborhood Hits	1921	Shared Neighborhood Hits	86
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

MYH14_HUMAN
NC score	0.021916 (rank : 497)	θ value	4.03905 (rank : 286)
Query Neighborhood Hits	375	Target Neighborhood Hits	995	Shared Neighborhood Hits	49
SwissProt Accessions	Q7Z406, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882	Gene names	MYH14, KIAA2034
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

TTDN1_HUMAN
NC score	0.021819 (rank : 498)	θ value	5.27518 (rank : 317)
Query Neighborhood Hits	375	Target Neighborhood Hits	43	Shared Neighborhood Hits	7
SwissProt Accessions	Q8TAP9	Gene names	TTDN1, C7orf11
Domain Architecture	No domain graphic available
Description	TTD non-photosensitive 1 protein.

RGS7_HUMAN
NC score	0.021788 (rank : 499)	θ value	8.99809 (rank : 369)
Query Neighborhood Hits	375	Target Neighborhood Hits	82	Shared Neighborhood Hits	12
SwissProt Accessions	P49802, Q8TD66, Q8TD67, Q9UNU7, Q9Y6B9	Gene names	RGS7
Domain Architecture
Description	Regulator of G-protein signaling 7 (RGS7).

MECP2_MOUSE
NC score	0.021628 (rank : 500)	θ value	5.27518 (rank : 302)
Query Neighborhood Hits	375	Target Neighborhood Hits	76	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Z2D6	Gene names	Mecp2
Domain Architecture
Description	Methyl-CpG-binding protein 2 (MeCP-2 protein) (MeCP2).

ZMYM3_MOUSE
NC score	0.021416 (rank : 501)	θ value	8.99809 (rank : 375)
Query Neighborhood Hits	375	Target Neighborhood Hits	177	Shared Neighborhood Hits	18
SwissProt Accessions	Q9JLM4, Q80U17	Gene names	Zmym3, Kiaa0385, Zfp261, Znf261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261) (DXHXS6673E protein).

MYH4_HUMAN
NC score	0.021117 (rank : 502)	θ value	1.06291 (rank : 227)
Query Neighborhood Hits	375	Target Neighborhood Hits	1377	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

N4BP3_HUMAN
NC score	0.020754 (rank : 503)	θ value	5.27518 (rank : 305)
Query Neighborhood Hits	375	Target Neighborhood Hits	156	Shared Neighborhood Hits	16
SwissProt Accessions	O15049, Q7Z6I3	Gene names	N4BP3, KIAA0341
Domain Architecture
Description	NEDD4-binding protein 3 (N4BP3).

CO8A2_HUMAN
NC score	0.020670 (rank : 504)	θ value	6.88961 (rank : 324)
Query Neighborhood Hits	375	Target Neighborhood Hits	299	Shared Neighborhood Hits	27
SwissProt Accessions	P25067, Q8TEJ5	Gene names	COL8A2
Domain Architecture
Description	Collagen alpha-2(VIII) chain precursor (Endothelial collagen).

CE016_HUMAN
NC score	0.019883 (rank : 505)	θ value	2.36792 (rank : 247)
Query Neighborhood Hits	375	Target Neighborhood Hits	80	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NC24, Q6P4E7, Q6UXY2	Gene names	C5orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C5orf16.

CONA1_MOUSE
NC score	0.018788 (rank : 506)	θ value	1.38821 (rank : 234)
Query Neighborhood Hits	375	Target Neighborhood Hits	254	Shared Neighborhood Hits	28
SwissProt Accessions	Q8K4G2, Q5SUQ0	Gene names	Col23a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXIII) chain.

GCH1_HUMAN
NC score	0.018240 (rank : 507)	θ value	2.36792 (rank : 251)
Query Neighborhood Hits	375	Target Neighborhood Hits	69	Shared Neighborhood Hits	5
SwissProt Accessions	P30793, Q9Y4I8	Gene names	GCH1, DYT5, GCH
Domain Architecture
Description	GTP cyclohydrolase I (EC 3.5.4.16) (GTP-CH-I).

GA2L2_HUMAN
NC score	0.018239 (rank : 508)	θ value	1.38821 (rank : 236)
Query Neighborhood Hits	375	Target Neighborhood Hits	175	Shared Neighborhood Hits	16
SwissProt Accessions	Q8NHY3, Q8NHY4	Gene names	GAS2L2, GAR17
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2) (GAS2-related protein on chromosome 17) (GAR17 protein).

PDXL2_MOUSE
NC score	0.017975 (rank : 509)	θ value	8.99809 (rank : 364)
Query Neighborhood Hits	375	Target Neighborhood Hits	213	Shared Neighborhood Hits	23
SwissProt Accessions	Q8CAE9, Q8CFW3	Gene names	Podxl2
Domain Architecture	No domain graphic available
Description	Podocalyxin-like protein 2 precursor (Endoglycan).

ZMYM3_HUMAN
NC score	0.016769 (rank : 510)	θ value	4.03905 (rank : 292)
Query Neighborhood Hits	375	Target Neighborhood Hits	223	Shared Neighborhood Hits	20
SwissProt Accessions	Q14202, O15089	Gene names	ZMYM3, DXS6673E, KIAA0385, ZNF261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261).

CJ006_HUMAN
NC score	0.016753 (rank : 511)	θ value	4.03905 (rank : 280)
Query Neighborhood Hits	375	Target Neighborhood Hits	122	Shared Neighborhood Hits	12
SwissProt Accessions	Q8IX21, Q5W0L8, Q9NPE8	Gene names	C10orf6
Domain Architecture	No domain graphic available
Description	Protein C10orf6.

GP153_MOUSE
NC score	0.016655 (rank : 512)	θ value	0.47712 (rank : 208)
Query Neighborhood Hits	375	Target Neighborhood Hits	204	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K0Z9, Q80T37, Q8CFK0	Gene names	Gpr153, Pgr1
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 153 (G-protein coupled receptor PGR1).

MINK1_HUMAN
NC score	0.016365 (rank : 513)	θ value	6.88961 (rank : 333)
Query Neighborhood Hits	375	Target Neighborhood Hits	1477	Shared Neighborhood Hits	73
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

SFR14_MOUSE
NC score	0.015796 (rank : 514)	θ value	2.36792 (rank : 258)
Query Neighborhood Hits	375	Target Neighborhood Hits	238	Shared Neighborhood Hits	21
SwissProt Accessions	Q8CH09, Q6PG19, Q80UY8, Q8BY32, Q8CFM0	Gene names	Sfrs14
Domain Architecture	No domain graphic available
Description	Putative splicing factor, arginine/serine-rich 14 (Arginine/serine- rich-splicing factor 14).

HSF1_HUMAN
NC score	0.015758 (rank : 515)	θ value	1.38821 (rank : 237)
Query Neighborhood Hits	375	Target Neighborhood Hits	163	Shared Neighborhood Hits	11
SwissProt Accessions	Q00613	Gene names	HSF1, HSTF1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

BLK_MOUSE
NC score	0.015514 (rank : 516)	θ value	4.03905 (rank : 279)
Query Neighborhood Hits	375	Target Neighborhood Hits	992	Shared Neighborhood Hits	38
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

KIF17_MOUSE
NC score	0.015319 (rank : 517)	θ value	0.0563607 (rank : 168)
Query Neighborhood Hits	375	Target Neighborhood Hits	452	Shared Neighborhood Hits	33
SwissProt Accessions	Q99PW8	Gene names	Kif17
Domain Architecture
Description	Kinesin-like protein KIF17 (MmKIF17).

PHLA1_HUMAN
NC score	0.014807 (rank : 518)	θ value	6.88961 (rank : 340)
Query Neighborhood Hits	375	Target Neighborhood Hits	121	Shared Neighborhood Hits	12
SwissProt Accessions	Q8WV24, Q15184, Q2TAN2, Q9NZ17	Gene names	PHLDA1, PHRIP, TDAG51
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family A member 1 (T-cell death- associated gene 51 protein) (Apoptosis-associated nuclear protein) (Proline- and histidine-rich protein) (Proline- and glutamine-rich protein) (PQ-rich protein).

MYO15_HUMAN
NC score	0.014428 (rank : 519)	θ value	6.88961 (rank : 334)
Query Neighborhood Hits	375	Target Neighborhood Hits	671	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

DBP_MOUSE
NC score	0.014317 (rank : 520)	θ value	1.81305 (rank : 243)
Query Neighborhood Hits	375	Target Neighborhood Hits	137	Shared Neighborhood Hits	8
SwissProt Accessions	Q60925, Q8VCX3	Gene names	Dbp
Domain Architecture
Description	D site-binding protein (Albumin D box-binding protein) (Albumin D- element-binding protein).

CEP68_MOUSE
NC score	0.014304 (rank : 521)	θ value	6.88961 (rank : 322)
Query Neighborhood Hits	375	Target Neighborhood Hits	62	Shared Neighborhood Hits	9
SwissProt Accessions	Q8C0D9, Q3US49, Q5SW85, Q8R2V0	Gene names	Cep68
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 68 kDa (Cep68 protein).

TTC28_HUMAN
NC score	0.013770 (rank : 522)	θ value	5.27518 (rank : 316)
Query Neighborhood Hits	375	Target Neighborhood Hits	271	Shared Neighborhood Hits	21
SwissProt Accessions	Q96AY4, O95928, O95929, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5	Gene names	TTC28, KIAA1043
Domain Architecture
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

CO9A2_HUMAN
NC score	0.013428 (rank : 523)	θ value	2.36792 (rank : 248)
Query Neighborhood Hits	375	Target Neighborhood Hits	261	Shared Neighborhood Hits	24
SwissProt Accessions	Q14055	Gene names	COL9A2
Domain Architecture	No domain graphic available
Description	Collagen alpha-2(IX) chain precursor.

RFX1_HUMAN
NC score	0.013367 (rank : 524)	θ value	3.0926 (rank : 270)
Query Neighborhood Hits	375	Target Neighborhood Hits	256	Shared Neighborhood Hits	25
SwissProt Accessions	P22670	Gene names	RFX1
Domain Architecture
Description	MHC class II regulatory factor RFX1 (RFX) (Enhancer factor C) (EF-C).

TULP4_HUMAN
NC score	0.013265 (rank : 525)	θ value	3.0926 (rank : 275)
Query Neighborhood Hits	375	Target Neighborhood Hits	426	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NRJ4, Q9HD22, Q9P2F0	Gene names	TULP4, KIAA1397, TUSP
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

GR65_HUMAN
NC score	0.013261 (rank : 526)	θ value	8.99809 (rank : 357)
Query Neighborhood Hits	375	Target Neighborhood Hits	148	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BQQ3, Q8N272, Q96H42	Gene names	GORASP1, GRASP65
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 1 (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5).

SRCA_HUMAN
NC score	0.012872 (rank : 527)	θ value	8.99809 (rank : 371)
Query Neighborhood Hits	375	Target Neighborhood Hits	380	Shared Neighborhood Hits	26
SwissProt Accessions	Q86TD4	Gene names	SRL
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

FILA_HUMAN
NC score	0.012845 (rank : 528)	θ value	8.99809 (rank : 353)
Query Neighborhood Hits	375	Target Neighborhood Hits	685	Shared Neighborhood Hits	37
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

CO9A2_MOUSE
NC score	0.012610 (rank : 529)	θ value	8.99809 (rank : 351)
Query Neighborhood Hits	375	Target Neighborhood Hits	279	Shared Neighborhood Hits	22
SwissProt Accessions	Q07643	Gene names	Col9a2
Domain Architecture	No domain graphic available
Description	Collagen alpha-2(IX) chain precursor.

RP1L1_MOUSE
NC score	0.012490 (rank : 530)	θ value	5.27518 (rank : 311)
Query Neighborhood Hits	375	Target Neighborhood Hits	170	Shared Neighborhood Hits	14
SwissProt Accessions	Q8CGM2, Q8K0I4	Gene names	Rp1l1, Rp1hl1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein (Retinitis pigmentosa 1-like protein 1).

TXD12_HUMAN
NC score	0.012382 (rank : 531)	θ value	6.88961 (rank : 345)
Query Neighborhood Hits	375	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	O95881, Q5T1T4, Q96H50	Gene names	TXNDC12, TLP19
Domain Architecture
Description	Thioredoxin domain-containing protein 12 precursor (EC 1.8.4.2) (Thioredoxin-like protein p19) (Endoplasmic reticulum protein ERp19) (ERp18) (hTLP19).

TXD12_MOUSE
NC score	0.012365 (rank : 532)	θ value	6.88961 (rank : 346)
Query Neighborhood Hits	375	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CQU0, Q53YN1	Gene names	Txndc12, Tlp19
Domain Architecture
Description	Thioredoxin domain-containing protein 12 precursor (EC 1.8.4.2) (Thioredoxin-like protein p19) (Endoplasmic reticulum protein ERp19).

PKCB1_HUMAN
NC score	0.012094 (rank : 533)	θ value	8.99809 (rank : 365)
Query Neighborhood Hits	375	Target Neighborhood Hits	488	Shared Neighborhood Hits	29
SwissProt Accessions	Q9ULU4, Q13517, Q4JJ94, Q4JJ95, Q5TH09, Q6MZM1, Q8WXC5, Q9H1F3, Q9H1F4, Q9H1F5, Q9H1L8, Q9H1L9, Q9H2G5, Q9NYN3, Q9UIX6	Gene names	PRKCBP1, KIAA1125, RACK7, ZMYND8
Domain Architecture
Description	Protein kinase C-binding protein 1 (Rack7) (Cutaneous T-cell lymphoma- associated antigen se14-3) (CTCL tumor antigen se14-3) (Zinc finger MYND domain-containing protein 8).

CO4A2_MOUSE
NC score	0.010842 (rank : 534)	θ value	4.03905 (rank : 281)
Query Neighborhood Hits	375	Target Neighborhood Hits	492	Shared Neighborhood Hits	38
SwissProt Accessions	P08122, Q61375	Gene names	Col4a2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

GLDN_MOUSE
NC score	0.010600 (rank : 535)	θ value	2.36792 (rank : 252)
Query Neighborhood Hits	375	Target Neighborhood Hits	155	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BMF8, Q80ZC5	Gene names	Gldn, Crgl2
Domain Architecture	No domain graphic available
Description	Gliomedin (Cancer-related gene liver 2 protein) (CRG-L2).

NTKL_HUMAN
NC score	0.010600 (rank : 536)	θ value	6.88961 (rank : 336)
Query Neighborhood Hits	375	Target Neighborhood Hits	266	Shared Neighborhood Hits	14
SwissProt Accessions	Q96KG9, Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53	Gene names	SCYL1, GKLP, NTKL, TAPK, TEIF, TRAP
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (Teratoma- associated tyrosine kinase) (Telomerase transcriptional element- interacting factor) (Telomerase regulation-associated protein).

SRPK1_HUMAN
NC score	0.010021 (rank : 537)	θ value	5.27518 (rank : 313)
Query Neighborhood Hits	375	Target Neighborhood Hits	706	Shared Neighborhood Hits	32
SwissProt Accessions	Q96SB4, Q12890, Q5R364, Q5R365, Q8IY12	Gene names	SRPK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

ZC3H6_MOUSE
NC score	0.009727 (rank : 538)	θ value	8.99809 (rank : 374)
Query Neighborhood Hits	375	Target Neighborhood Hits	239	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BYK8, Q80UK3, Q8C1H1, Q9D604	Gene names	Zc3h6, Zc3hdc6
Domain Architecture
Description	Zinc finger CCCH domain-containing protein 6.

TEX14_HUMAN
NC score	0.009708 (rank : 539)	θ value	2.36792 (rank : 260)
Query Neighborhood Hits	375	Target Neighborhood Hits	1103	Shared Neighborhood Hits	42
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

WNK1_MOUSE
NC score	0.009673 (rank : 540)	θ value	8.99809 (rank : 373)
Query Neighborhood Hits	375	Target Neighborhood Hits	1179	Shared Neighborhood Hits	50
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

CABL2_MOUSE
NC score	0.009573 (rank : 541)	θ value	6.88961 (rank : 320)
Query Neighborhood Hits	375	Target Neighborhood Hits	79	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K3M5	Gene names	Cables2
Domain Architecture
Description	CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2).

EXTL1_HUMAN
NC score	0.009549 (rank : 542)	θ value	2.36792 (rank : 250)
Query Neighborhood Hits	375	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q92935, Q6GSC1	Gene names	EXTL1, EXTL
Domain Architecture
Description	Exostosin-like 1 (EC 2.4.1.224) (Glucuronosyl-N-acetylglucosaminyl- proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Exostosin-L) (Multiple exostosis-like protein).

AQR_HUMAN
NC score	0.009154 (rank : 543)	θ value	5.27518 (rank : 295)
Query Neighborhood Hits	375	Target Neighborhood Hits	88	Shared Neighborhood Hits	7
SwissProt Accessions	O60306, Q2YDX9, Q6IRU8, Q6PIC8	Gene names	AQR, KIAA0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius (Intron-binding protein of 160 kDa) (IBP160).

ZIM10_MOUSE
NC score	0.008510 (rank : 544)	θ value	6.88961 (rank : 347)
Query Neighborhood Hits	375	Target Neighborhood Hits	430	Shared Neighborhood Hits	29
SwissProt Accessions	Q6P1E1, Q6PDK9, Q6PF85, Q8BW47	Gene names	Rai17, Zimp10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

NHEJ1_MOUSE
NC score	0.008428 (rank : 545)	θ value	8.99809 (rank : 363)
Query Neighborhood Hits	375	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q3KNJ2, Q99JK0, Q9D9U0	Gene names	Nhej1, Xlf
Domain Architecture	No domain graphic available
Description	Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor).

SOX30_HUMAN
NC score	0.008366 (rank : 546)	θ value	3.0926 (rank : 273)
Query Neighborhood Hits	375	Target Neighborhood Hits	305	Shared Neighborhood Hits	16
SwissProt Accessions	O94993, O94995, Q8IYX6	Gene names	SOX30
Domain Architecture
Description	Transcription factor SOX-30.

COEA1_HUMAN
NC score	0.008130 (rank : 547)	θ value	5.27518 (rank : 297)
Query Neighborhood Hits	375	Target Neighborhood Hits	427	Shared Neighborhood Hits	26
SwissProt Accessions	Q05707, O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67	Gene names	COL14A1, UND
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor (Undulin).

NFAC2_HUMAN
NC score	0.007982 (rank : 548)	θ value	6.88961 (rank : 335)
Query Neighborhood Hits	375	Target Neighborhood Hits	101	Shared Neighborhood Hits	14
SwissProt Accessions	Q13469, Q13468, Q5TFW7, Q5TFW8, Q9NPX6, Q9NQH3, Q9UJR2	Gene names	NFATC2, NFAT1, NFATP
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 2 (T cell transcription factor NFAT1) (NFAT pre-existing subunit) (NF-ATp).

HXA3_MOUSE
NC score	0.007961 (rank : 549)	θ value	1.06291 (rank : 224)
Query Neighborhood Hits	375	Target Neighborhood Hits	558	Shared Neighborhood Hits	37
SwissProt Accessions	P02831, Q4V9Z8, Q61197	Gene names	Hoxa3, Hox-1.5, Hoxa-3
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1.5) (MO-10).

K1958_HUMAN
NC score	0.007816 (rank : 550)	θ value	8.99809 (rank : 360)
Query Neighborhood Hits	375	Target Neighborhood Hits	76	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N8K9, Q5T252, Q8TF43, Q96N02	Gene names	KIAA1958
Domain Architecture	No domain graphic available
Description	Protein KIAA1958.

ADIPO_MOUSE
NC score	0.007674 (rank : 551)	θ value	1.38821 (rank : 233)
Query Neighborhood Hits	375	Target Neighborhood Hits	182	Shared Neighborhood Hits	13
SwissProt Accessions	Q60994, Q62400, Q9DC68	Gene names	Adipoq, Acdc, Acrp30, Apm1
Domain Architecture
Description	Adiponectin precursor (Adipocyte, C1q and collagen domain-containing protein) (30 kDa adipocyte complement-related protein) (Adipocyte complement-related 30 kDa protein) (ACRP30) (Adipocyte-specific protein AdipoQ).

SOX9_HUMAN
NC score	0.007549 (rank : 552)	θ value	5.27518 (rank : 312)
Query Neighborhood Hits	375	Target Neighborhood Hits	210	Shared Neighborhood Hits	19
SwissProt Accessions	P48436	Gene names	SOX9
Domain Architecture
Description	Transcription factor SOX-9.

SOX10_HUMAN
NC score	0.006251 (rank : 553)	θ value	4.03905 (rank : 291)
Query Neighborhood Hits	375	Target Neighborhood Hits	122	Shared Neighborhood Hits	10
SwissProt Accessions	P56693	Gene names	SOX10
Domain Architecture
Description	Transcription factor SOX-10.

DDFL1_HUMAN
NC score	0.005608 (rank : 554)	θ value	6.88961 (rank : 327)
Query Neighborhood Hits	375	Target Neighborhood Hits	353	Shared Neighborhood Hits	13
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

L2GL1_HUMAN
NC score	0.005576 (rank : 555)	θ value	5.27518 (rank : 301)
Query Neighborhood Hits	375	Target Neighborhood Hits	64	Shared Neighborhood Hits	4
SwissProt Accessions	Q15334, O00188, Q58F11, Q86UK6	Gene names	LLGL1, HUGL
Domain Architecture	No domain graphic available
Description	Lethal(2) giant larvae protein homolog 1 (LLGL) (Human homolog to the D-lgl gene) (Hugl-1) (DLG4).

HXA3_HUMAN
NC score	0.005332 (rank : 556)	θ value	4.03905 (rank : 283)
Query Neighborhood Hits	375	Target Neighborhood Hits	535	Shared Neighborhood Hits	39
SwissProt Accessions	O43365	Gene names	HOXA3, HOX1E
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1E).

SLIK5_HUMAN
NC score	0.004405 (rank : 557)	θ value	4.03905 (rank : 289)
Query Neighborhood Hits	375	Target Neighborhood Hits	302	Shared Neighborhood Hits	13
SwissProt Accessions	O94991	Gene names	SLITRK5, KIAA0918, LRRC11
Domain Architecture
Description	SLIT and NTRK-like protein 5 precursor (Leucine-rich repeat-containing protein 11).

CLPB_HUMAN
NC score	0.003912 (rank : 558)	θ value	6.88961 (rank : 323)
Query Neighborhood Hits	375	Target Neighborhood Hits	265	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H078, Q8ND11, Q9H8Y0	Gene names	CLPB, SKD3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

CHD1_HUMAN
NC score	0.003784 (rank : 559)	θ value	8.99809 (rank : 350)
Query Neighborhood Hits	375	Target Neighborhood Hits	337	Shared Neighborhood Hits	21
SwissProt Accessions	O14646	Gene names	CHD1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

INVS_MOUSE
NC score	0.000082 (rank : 560)	θ value	8.99809 (rank : 359)
Query Neighborhood Hits	375	Target Neighborhood Hits	609	Shared Neighborhood Hits	21
SwissProt Accessions	O89019, O88849	Gene names	Invs, Inv, Nphp2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning protein) (Nephrocystin-2).

FOXD2_HUMAN
NC score	-0.000803 (rank : 561)	θ value	8.99809 (rank : 354)
Query Neighborhood Hits	375	Target Neighborhood Hits	143	Shared Neighborhood Hits	8
SwissProt Accessions	O60548	Gene names	FOXD2, FKHL17, FREAC9
Domain Architecture
Description	Forkhead box protein D2 (Forkhead-related protein FKHL17) (Forkhead- related transcription factor 9) (FREAC-9).

ZEP1_HUMAN
NC score	-0.002285 (rank : 562)	θ value	2.36792 (rank : 261)
Query Neighborhood Hits	375	Target Neighborhood Hits	1036	Shared Neighborhood Hits	30
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

CSPG2_HUMAN
NC score	-0.002788 (rank : 563)	θ value	6.88961 (rank : 326)
Query Neighborhood Hits	375	Target Neighborhood Hits	681	Shared Neighborhood Hits	12
SwissProt Accessions	P13611, P20754, Q13010, Q13189, Q15123, Q9UCL9, Q9UNW5	Gene names	CSPG2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M) (Glial hyaluronate-binding protein) (GHAP).

BARH1_MOUSE
NC score	-0.003048 (rank : 564)	θ value	6.88961 (rank : 319)
Query Neighborhood Hits	375	Target Neighborhood Hits	350	Shared Neighborhood Hits	4
SwissProt Accessions	P63157, Q9JK26	Gene names	Barhl1, Bhx1, Mbh2
Domain Architecture	No domain graphic available
Description	BarH-like 1 homeobox protein (Bar-class homeodomain protein MBH2) (BarH-related homeobox protein 1).

GLI3_HUMAN
NC score	-0.006207 (rank : 565)	θ value	8.99809 (rank : 356)
Query Neighborhood Hits	375	Target Neighborhood Hits	871	Shared Neighborhood Hits	23
SwissProt Accessions	P10071, O75219, Q9UDT5, Q9UJ39	Gene names	GLI3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI3.

ZN142_HUMAN
NC score	-0.006718 (rank : 566)	θ value	4.03905 (rank : 293)
Query Neighborhood Hits	375	Target Neighborhood Hits	1007	Shared Neighborhood Hits	28
SwissProt Accessions	P52746, Q92510	Gene names	ZNF142, KIAA0236
Domain Architecture	No domain graphic available
Description	Zinc finger protein 142 (HA4654).

ZBT7A_MOUSE
NC score	-0.007519 (rank : 567)	θ value	0.62314 (rank : 220)
Query Neighborhood Hits	375	Target Neighborhood Hits	795	Shared Neighborhood Hits	7
SwissProt Accessions	O88939, Q9CRJ0	Gene names	Zbtb7a, Lrf, Zbtb7
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 7A (Leukemia/lymphoma- related factor).

ZN282_HUMAN
NC score	-0.007914 (rank : 568)	θ value	1.81305 (rank : 245)
Query Neighborhood Hits	375	Target Neighborhood Hits	796	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UDV7, O43691, Q6DKK0	Gene names	ZNF282, HUB1
Domain Architecture
Description	Zinc finger protein 282 (HTLV-I U5RE-binding protein 1) (HUB-1).

ZN694_HUMAN
NC score	-0.008476 (rank : 569)	θ value	3.0926 (rank : 278)
Query Neighborhood Hits	375	Target Neighborhood Hits	764	Shared Neighborhood Hits	10
SwissProt Accessions	Q63HK3, Q6ZN77	Gene names	ZNF694
Domain Architecture	No domain graphic available
Description	Zinc finger protein 694.