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Network neighborhood for query Sequence : MPDZ_MOUSE

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MPDZ_MOUSE
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

INADL_MOUSE
θ value	0 (rank : 1)	NC score	0.956862 (rank : 4)
Query Neighborhood Hits	298	Target Neighborhood Hits	290	Shared Neighborhood Hits	203
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

MPDZ_HUMAN
θ value	0 (rank : 2)	NC score	0.993773 (rank : 2)
Query Neighborhood Hits	298	Target Neighborhood Hits	261	Shared Neighborhood Hits	220
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

MPDZ_MOUSE
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	298	Target Neighborhood Hits	298	Shared Neighborhood Hits	298
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

INADL_HUMAN
θ value	1.05253e-149 (rank : 4)	NC score	0.958046 (rank : 3)
Query Neighborhood Hits	298	Target Neighborhood Hits	260	Shared Neighborhood Hits	198
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

LNX2_MOUSE
θ value	3.84025e-59 (rank : 5)	NC score	0.833689 (rank : 5)
Query Neighborhood Hits	298	Target Neighborhood Hits	407	Shared Neighborhood Hits	178
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

LNX1_HUMAN
θ value	1.78386e-56 (rank : 6)	NC score	0.820285 (rank : 9)
Query Neighborhood Hits	298	Target Neighborhood Hits	379	Shared Neighborhood Hits	171
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

LNX2_HUMAN
θ value	1.15626e-55 (rank : 7)	NC score	0.827292 (rank : 7)
Query Neighborhood Hits	298	Target Neighborhood Hits	389	Shared Neighborhood Hits	178
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

LNX1_MOUSE
θ value	7.49467e-55 (rank : 8)	NC score	0.824746 (rank : 8)
Query Neighborhood Hits	298	Target Neighborhood Hits	377	Shared Neighborhood Hits	179
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

LAP4_HUMAN
θ value	6.37413e-38 (rank : 9)	NC score	0.551118 (rank : 77)
Query Neighborhood Hits	298	Target Neighborhood Hits	608	Shared Neighborhood Hits	208
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

LAP4_MOUSE
θ value	3.4976e-36 (rank : 10)	NC score	0.545594 (rank : 78)
Query Neighborhood Hits	298	Target Neighborhood Hits	590	Shared Neighborhood Hits	207
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

PTN13_HUMAN
θ value	2.26708e-35 (rank : 11)	NC score	0.491549 (rank : 83)
Query Neighborhood Hits	298	Target Neighborhood Hits	471	Shared Neighborhood Hits	197
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

DLG4_HUMAN
θ value	2.59387e-31 (rank : 12)	NC score	0.761526 (rank : 24)
Query Neighborhood Hits	298	Target Neighborhood Hits	286	Shared Neighborhood Hits	185
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_MOUSE
θ value	3.3877e-31 (rank : 13)	NC score	0.762646 (rank : 23)
Query Neighborhood Hits	298	Target Neighborhood Hits	282	Shared Neighborhood Hits	187
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

PDZD2_HUMAN
θ value	4.14116e-29 (rank : 14)	NC score	0.769436 (rank : 21)
Query Neighborhood Hits	298	Target Neighborhood Hits	772	Shared Neighborhood Hits	215
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

DLG1_MOUSE
θ value	1.57365e-28 (rank : 15)	NC score	0.746163 (rank : 29)
Query Neighborhood Hits	298	Target Neighborhood Hits	285	Shared Neighborhood Hits	177
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

DLG1_HUMAN
θ value	7.80994e-28 (rank : 16)	NC score	0.746140 (rank : 30)
Query Neighborhood Hits	298	Target Neighborhood Hits	290	Shared Neighborhood Hits	179
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

MAGI1_HUMAN
θ value	1.62847e-25 (rank : 17)	NC score	0.727146 (rank : 37)
Query Neighborhood Hits	298	Target Neighborhood Hits	388	Shared Neighborhood Hits	203
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

DLG3_MOUSE
θ value	3.62785e-25 (rank : 18)	NC score	0.748538 (rank : 28)
Query Neighborhood Hits	298	Target Neighborhood Hits	274	Shared Neighborhood Hits	185
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

PTN13_MOUSE
θ value	6.18819e-25 (rank : 19)	NC score	0.476514 (rank : 90)
Query Neighborhood Hits	298	Target Neighborhood Hits	426	Shared Neighborhood Hits	193
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

DLG2_HUMAN
θ value	1.05554e-24 (rank : 20)	NC score	0.736618 (rank : 32)
Query Neighborhood Hits	298	Target Neighborhood Hits	279	Shared Neighborhood Hits	184
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG2_MOUSE
θ value	1.80048e-24 (rank : 21)	NC score	0.736614 (rank : 33)
Query Neighborhood Hits	298	Target Neighborhood Hits	271	Shared Neighborhood Hits	182
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG3_HUMAN
θ value	3.07116e-24 (rank : 22)	NC score	0.743816 (rank : 31)
Query Neighborhood Hits	298	Target Neighborhood Hits	269	Shared Neighborhood Hits	185
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

PARD3_MOUSE
θ value	4.01107e-24 (rank : 23)	NC score	0.793894 (rank : 11)
Query Neighborhood Hits	298	Target Neighborhood Hits	290	Shared Neighborhood Hits	167
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

PARD3_HUMAN
θ value	3.39556e-23 (rank : 24)	NC score	0.792355 (rank : 12)
Query Neighborhood Hits	298	Target Neighborhood Hits	312	Shared Neighborhood Hits	170
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

MAGI1_MOUSE
θ value	1.42661e-21 (rank : 25)	NC score	0.723935 (rank : 38)
Query Neighborhood Hits	298	Target Neighborhood Hits	403	Shared Neighborhood Hits	202
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

PAR3L_HUMAN
θ value	5.42112e-21 (rank : 26)	NC score	0.804569 (rank : 10)
Query Neighborhood Hits	298	Target Neighborhood Hits	297	Shared Neighborhood Hits	157
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

GRIP2_HUMAN
θ value	7.0802e-21 (rank : 27)	NC score	0.772382 (rank : 18)
Query Neighborhood Hits	298	Target Neighborhood Hits	256	Shared Neighborhood Hits	197
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

MAGI2_MOUSE
θ value	2.27762e-19 (rank : 28)	NC score	0.696125 (rank : 42)
Query Neighborhood Hits	298	Target Neighborhood Hits	370	Shared Neighborhood Hits	196
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

IL16_HUMAN
θ value	4.29542e-18 (rank : 29)	NC score	0.761358 (rank : 25)
Query Neighborhood Hits	298	Target Neighborhood Hits	207	Shared Neighborhood Hits	145
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

PDZD1_MOUSE
θ value	9.56915e-18 (rank : 30)	NC score	0.719589 (rank : 39)
Query Neighborhood Hits	298	Target Neighborhood Hits	191	Shared Neighborhood Hits	165
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PZRN3_HUMAN
θ value	3.63628e-17 (rank : 31)	NC score	0.625608 (rank : 59)
Query Neighborhood Hits	298	Target Neighborhood Hits	461	Shared Neighborhood Hits	157
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PDZD1_HUMAN
θ value	4.74913e-17 (rank : 32)	NC score	0.707955 (rank : 41)
Query Neighborhood Hits	298	Target Neighborhood Hits	190	Shared Neighborhood Hits	165
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PZRN3_MOUSE
θ value	8.10077e-17 (rank : 33)	NC score	0.629571 (rank : 57)
Query Neighborhood Hits	298	Target Neighborhood Hits	447	Shared Neighborhood Hits	156
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

MAGI2_HUMAN
θ value	4.02038e-16 (rank : 34)	NC score	0.695059 (rank : 44)
Query Neighborhood Hits	298	Target Neighborhood Hits	373	Shared Neighborhood Hits	196
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

GRIP1_HUMAN
θ value	1.16975e-15 (rank : 35)	NC score	0.752856 (rank : 26)
Query Neighborhood Hits	298	Target Neighborhood Hits	231	Shared Neighborhood Hits	194
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

IL16_MOUSE
θ value	1.52774e-15 (rank : 36)	NC score	0.731211 (rank : 34)
Query Neighborhood Hits	298	Target Neighborhood Hits	189	Shared Neighborhood Hits	138
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

PZRN4_HUMAN
θ value	1.52774e-15 (rank : 37)	NC score	0.635760 (rank : 55)
Query Neighborhood Hits	298	Target Neighborhood Hits	438	Shared Neighborhood Hits	154
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

NEB1_HUMAN
θ value	1.99529e-15 (rank : 38)	NC score	0.508320 (rank : 80)
Query Neighborhood Hits	298	Target Neighborhood Hits	829	Shared Neighborhood Hits	146
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

ZO1_HUMAN
θ value	2.60593e-15 (rank : 39)	NC score	0.600347 (rank : 70)
Query Neighborhood Hits	298	Target Neighborhood Hits	474	Shared Neighborhood Hits	180
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

GRIP1_MOUSE
θ value	3.40345e-15 (rank : 40)	NC score	0.749224 (rank : 27)
Query Neighborhood Hits	298	Target Neighborhood Hits	241	Shared Neighborhood Hits	194
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

NEB2_HUMAN
θ value	9.90251e-15 (rank : 41)	NC score	0.480127 (rank : 88)
Query Neighborhood Hits	298	Target Neighborhood Hits	883	Shared Neighborhood Hits	131
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEB2_MOUSE
θ value	9.90251e-15 (rank : 42)	NC score	0.474089 (rank : 91)
Query Neighborhood Hits	298	Target Neighborhood Hits	889	Shared Neighborhood Hits	132
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

USH1C_HUMAN
θ value	2.20605e-14 (rank : 43)	NC score	0.766639 (rank : 22)
Query Neighborhood Hits	298	Target Neighborhood Hits	327	Shared Neighborhood Hits	193
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

ZO1_MOUSE
θ value	1.09485e-13 (rank : 44)	NC score	0.607698 (rank : 66)
Query Neighborhood Hits	298	Target Neighborhood Hits	453	Shared Neighborhood Hits	184
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

LIN7A_HUMAN
θ value	4.16044e-13 (rank : 45)	NC score	0.770517 (rank : 19)
Query Neighborhood Hits	298	Target Neighborhood Hits	193	Shared Neighborhood Hits	187
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7A_MOUSE
θ value	4.16044e-13 (rank : 46)	NC score	0.770506 (rank : 20)
Query Neighborhood Hits	298	Target Neighborhood Hits	193	Shared Neighborhood Hits	187
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

LIN7B_HUMAN
θ value	4.16044e-13 (rank : 47)	NC score	0.777028 (rank : 13)
Query Neighborhood Hits	298	Target Neighborhood Hits	200	Shared Neighborhood Hits	191
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

SYJ2B_HUMAN
θ value	4.16044e-13 (rank : 48)	NC score	0.833564 (rank : 6)
Query Neighborhood Hits	298	Target Neighborhood Hits	162	Shared Neighborhood Hits	160
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

LIN7B_MOUSE
θ value	5.43371e-13 (rank : 49)	NC score	0.775072 (rank : 15)
Query Neighborhood Hits	298	Target Neighborhood Hits	200	Shared Neighborhood Hits	191
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

WHRN_MOUSE
θ value	5.43371e-13 (rank : 50)	NC score	0.727742 (rank : 36)
Query Neighborhood Hits	298	Target Neighborhood Hits	412	Shared Neighborhood Hits	195
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

USH1C_MOUSE
θ value	7.09661e-13 (rank : 51)	NC score	0.713940 (rank : 40)
Query Neighborhood Hits	298	Target Neighborhood Hits	557	Shared Neighborhood Hits	200
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

AFAD_HUMAN
θ value	1.2105e-12 (rank : 52)	NC score	0.536095 (rank : 79)
Query Neighborhood Hits	298	Target Neighborhood Hits	689	Shared Neighborhood Hits	145
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

LIN7C_HUMAN
θ value	1.58096e-12 (rank : 53)	NC score	0.772522 (rank : 16)
Query Neighborhood Hits	298	Target Neighborhood Hits	198	Shared Neighborhood Hits	189
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
θ value	1.58096e-12 (rank : 54)	NC score	0.772522 (rank : 17)
Query Neighborhood Hits	298	Target Neighborhood Hits	198	Shared Neighborhood Hits	189
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

WHRN_HUMAN
θ value	3.52202e-12 (rank : 55)	NC score	0.729943 (rank : 35)
Query Neighborhood Hits	298	Target Neighborhood Hits	325	Shared Neighborhood Hits	196
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

PDZD7_HUMAN
θ value	6.00763e-12 (rank : 56)	NC score	0.775972 (rank : 14)
Query Neighborhood Hits	298	Target Neighborhood Hits	181	Shared Neighborhood Hits	171
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

NHRF2_HUMAN
θ value	1.33837e-11 (rank : 57)	NC score	0.664685 (rank : 48)
Query Neighborhood Hits	298	Target Neighborhood Hits	197	Shared Neighborhood Hits	177
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

K1849_MOUSE
θ value	2.28291e-11 (rank : 58)	NC score	0.566775 (rank : 76)
Query Neighborhood Hits	298	Target Neighborhood Hits	335	Shared Neighborhood Hits	154
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

NHERF_MOUSE
θ value	3.89403e-11 (rank : 59)	NC score	0.678900 (rank : 46)
Query Neighborhood Hits	298	Target Neighborhood Hits	195	Shared Neighborhood Hits	167
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHRF2_MOUSE
θ value	1.47974e-10 (rank : 60)	NC score	0.653606 (rank : 51)
Query Neighborhood Hits	298	Target Neighborhood Hits	194	Shared Neighborhood Hits	177
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

SNTG2_HUMAN
θ value	1.9326e-10 (rank : 61)	NC score	0.655960 (rank : 50)
Query Neighborhood Hits	298	Target Neighborhood Hits	191	Shared Neighborhood Hits	182
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

PDZD3_HUMAN
θ value	5.62301e-10 (rank : 62)	NC score	0.652404 (rank : 52)
Query Neighborhood Hits	298	Target Neighborhood Hits	180	Shared Neighborhood Hits	166
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

NHERF_HUMAN
θ value	7.34386e-10 (rank : 63)	NC score	0.650051 (rank : 53)
Query Neighborhood Hits	298	Target Neighborhood Hits	190	Shared Neighborhood Hits	166
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

SNTA1_HUMAN
θ value	2.13673e-09 (rank : 64)	NC score	0.618218 (rank : 65)
Query Neighborhood Hits	298	Target Neighborhood Hits	186	Shared Neighborhood Hits	168
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

K1849_HUMAN
θ value	2.79066e-09 (rank : 65)	NC score	0.579011 (rank : 73)
Query Neighborhood Hits	298	Target Neighborhood Hits	220	Shared Neighborhood Hits	143
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

SNTB1_MOUSE
θ value	3.64472e-09 (rank : 66)	NC score	0.588809 (rank : 72)
Query Neighborhood Hits	298	Target Neighborhood Hits	160	Shared Neighborhood Hits	150
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

SNTB1_HUMAN
θ value	4.76016e-09 (rank : 67)	NC score	0.591480 (rank : 71)
Query Neighborhood Hits	298	Target Neighborhood Hits	157	Shared Neighborhood Hits	152
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

SNTB2_MOUSE
θ value	8.11959e-09 (rank : 68)	NC score	0.623085 (rank : 62)
Query Neighborhood Hits	298	Target Neighborhood Hits	181	Shared Neighborhood Hits	163
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

SNTB2_HUMAN
θ value	1.38499e-08 (rank : 69)	NC score	0.622223 (rank : 63)
Query Neighborhood Hits	298	Target Neighborhood Hits	180	Shared Neighborhood Hits	163
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

STXB4_HUMAN
θ value	1.38499e-08 (rank : 70)	NC score	0.435843 (rank : 109)
Query Neighborhood Hits	298	Target Neighborhood Hits	616	Shared Neighborhood Hits	107
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_MOUSE
θ value	1.38499e-08 (rank : 71)	NC score	0.433722 (rank : 112)
Query Neighborhood Hits	298	Target Neighborhood Hits	629	Shared Neighborhood Hits	101
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

SNTG2_MOUSE
θ value	1.80886e-08 (rank : 72)	NC score	0.620162 (rank : 64)
Query Neighborhood Hits	298	Target Neighborhood Hits	176	Shared Neighborhood Hits	169
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SNTA1_MOUSE
θ value	3.08544e-08 (rank : 73)	NC score	0.606937 (rank : 69)
Query Neighborhood Hits	298	Target Neighborhood Hits	170	Shared Neighborhood Hits	162
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

SNTG1_MOUSE
θ value	4.0297e-08 (rank : 74)	NC score	0.607380 (rank : 67)
Query Neighborhood Hits	298	Target Neighborhood Hits	179	Shared Neighborhood Hits	173
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTG1_HUMAN
θ value	5.26297e-08 (rank : 75)	NC score	0.606983 (rank : 68)
Query Neighborhood Hits	298	Target Neighborhood Hits	181	Shared Neighborhood Hits	174
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

PDZD3_MOUSE
θ value	6.87365e-08 (rank : 76)	NC score	0.625838 (rank : 58)
Query Neighborhood Hits	298	Target Neighborhood Hits	171	Shared Neighborhood Hits	163
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

ZO3_HUMAN
θ value	6.87365e-08 (rank : 77)	NC score	0.624529 (rank : 61)
Query Neighborhood Hits	298	Target Neighborhood Hits	219	Shared Neighborhood Hits	178
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

APBA1_HUMAN
θ value	1.99992e-07 (rank : 78)	NC score	0.482143 (rank : 86)
Query Neighborhood Hits	298	Target Neighborhood Hits	325	Shared Neighborhood Hits	160
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

GOPC_HUMAN
θ value	1.99992e-07 (rank : 79)	NC score	0.657413 (rank : 49)
Query Neighborhood Hits	298	Target Neighborhood Hits	377	Shared Neighborhood Hits	175
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

GOPC_MOUSE
θ value	1.99992e-07 (rank : 80)	NC score	0.668038 (rank : 47)
Query Neighborhood Hits	298	Target Neighborhood Hits	323	Shared Neighborhood Hits	174
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

APBA2_HUMAN
θ value	3.41135e-07 (rank : 81)	NC score	0.466176 (rank : 96)
Query Neighborhood Hits	298	Target Neighborhood Hits	220	Shared Neighborhood Hits	151
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_MOUSE
θ value	3.41135e-07 (rank : 82)	NC score	0.466494 (rank : 95)
Query Neighborhood Hits	298	Target Neighborhood Hits	219	Shared Neighborhood Hits	150
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

DLG5_HUMAN
θ value	3.41135e-07 (rank : 83)	NC score	0.451027 (rank : 101)
Query Neighborhood Hits	298	Target Neighborhood Hits	1088	Shared Neighborhood Hits	183
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

ZO2_HUMAN
θ value	5.81887e-07 (rank : 84)	NC score	0.573376 (rank : 75)
Query Neighborhood Hits	298	Target Neighborhood Hits	289	Shared Neighborhood Hits	172
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZO3_MOUSE
θ value	5.81887e-07 (rank : 85)	NC score	0.624868 (rank : 60)
Query Neighborhood Hits	298	Target Neighborhood Hits	224	Shared Neighborhood Hits	184
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

ZO2_MOUSE
θ value	7.59969e-07 (rank : 86)	NC score	0.576521 (rank : 74)
Query Neighborhood Hits	298	Target Neighborhood Hits	296	Shared Neighborhood Hits	176
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

PDZ11_MOUSE
θ value	1.69304e-06 (rank : 87)	NC score	0.694658 (rank : 45)
Query Neighborhood Hits	298	Target Neighborhood Hits	154	Shared Neighborhood Hits	145
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZK4_HUMAN
θ value	2.21117e-06 (rank : 88)	NC score	0.496970 (rank : 81)
Query Neighborhood Hits	298	Target Neighborhood Hits	165	Shared Neighborhood Hits	121
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

DVL1_HUMAN
θ value	2.88788e-06 (rank : 89)	NC score	0.480589 (rank : 87)
Query Neighborhood Hits	298	Target Neighborhood Hits	158	Shared Neighborhood Hits	119
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL1_MOUSE
θ value	2.88788e-06 (rank : 90)	NC score	0.477416 (rank : 89)
Query Neighborhood Hits	298	Target Neighborhood Hits	146	Shared Neighborhood Hits	117
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

PDZ11_HUMAN
θ value	2.88788e-06 (rank : 91)	NC score	0.695083 (rank : 43)
Query Neighborhood Hits	298	Target Neighborhood Hits	160	Shared Neighborhood Hits	152
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

LRRC7_HUMAN
θ value	3.77169e-06 (rank : 92)	NC score	0.273253 (rank : 149)
Query Neighborhood Hits	298	Target Neighborhood Hits	423	Shared Neighborhood Hits	115
SwissProt Accessions	Q96NW7, Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2	Gene names	LRRC7, KIAA1365, LAP1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

LRRC7_MOUSE
θ value	3.77169e-06 (rank : 93)	NC score	0.272173 (rank : 150)
Query Neighborhood Hits	298	Target Neighborhood Hits	416	Shared Neighborhood Hits	113
SwissProt Accessions	Q80TE7	Gene names	Lrrc7, Kiaa1365, Lap1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

DVL1L_HUMAN
θ value	6.43352e-06 (rank : 94)	NC score	0.463466 (rank : 97)
Query Neighborhood Hits	298	Target Neighborhood Hits	146	Shared Neighborhood Hits	115
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

DVL2_HUMAN
θ value	6.43352e-06 (rank : 95)	NC score	0.461542 (rank : 98)
Query Neighborhood Hits	298	Target Neighborhood Hits	223	Shared Neighborhood Hits	117
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_MOUSE
θ value	6.43352e-06 (rank : 96)	NC score	0.461194 (rank : 99)
Query Neighborhood Hits	298	Target Neighborhood Hits	233	Shared Neighborhood Hits	114
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL3_HUMAN
θ value	6.43352e-06 (rank : 97)	NC score	0.483710 (rank : 84)
Query Neighborhood Hits	298	Target Neighborhood Hits	194	Shared Neighborhood Hits	116
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_MOUSE
θ value	6.43352e-06 (rank : 98)	NC score	0.483672 (rank : 85)
Query Neighborhood Hits	298	Target Neighborhood Hits	198	Shared Neighborhood Hits	116
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

PDZK4_MOUSE
θ value	8.40245e-06 (rank : 99)	NC score	0.494957 (rank : 82)
Query Neighborhood Hits	298	Target Neighborhood Hits	165	Shared Neighborhood Hits	125
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

LAP2_HUMAN
θ value	2.44474e-05 (rank : 100)	NC score	0.260405 (rank : 154)
Query Neighborhood Hits	298	Target Neighborhood Hits	499	Shared Neighborhood Hits	110
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

PAR6B_HUMAN
θ value	4.1701e-05 (rank : 101)	NC score	0.448343 (rank : 102)
Query Neighborhood Hits	298	Target Neighborhood Hits	126	Shared Neighborhood Hits	120
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6A_HUMAN
θ value	5.44631e-05 (rank : 102)	NC score	0.433113 (rank : 113)
Query Neighborhood Hits	298	Target Neighborhood Hits	119	Shared Neighborhood Hits	110
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

PAR6A_MOUSE
θ value	5.44631e-05 (rank : 103)	NC score	0.434139 (rank : 111)
Query Neighborhood Hits	298	Target Neighborhood Hits	115	Shared Neighborhood Hits	110
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

RIMS2_HUMAN
θ value	5.44631e-05 (rank : 104)	NC score	0.244690 (rank : 160)
Query Neighborhood Hits	298	Target Neighborhood Hits	342	Shared Neighborhood Hits	106
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	5.44631e-05 (rank : 105)	NC score	0.241684 (rank : 161)
Query Neighborhood Hits	298	Target Neighborhood Hits	376	Shared Neighborhood Hits	108
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

MY18A_MOUSE
θ value	9.29e-05 (rank : 106)	NC score	0.087217 (rank : 193)
Query Neighborhood Hits	298	Target Neighborhood Hits	1989	Shared Neighborhood Hits	155
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

PAR6B_MOUSE
θ value	9.29e-05 (rank : 107)	NC score	0.446083 (rank : 103)
Query Neighborhood Hits	298	Target Neighborhood Hits	128	Shared Neighborhood Hits	121
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PICK1_HUMAN
θ value	9.29e-05 (rank : 108)	NC score	0.470035 (rank : 94)
Query Neighborhood Hits	298	Target Neighborhood Hits	132	Shared Neighborhood Hits	122
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PICK1_MOUSE
θ value	9.29e-05 (rank : 109)	NC score	0.470455 (rank : 93)
Query Neighborhood Hits	298	Target Neighborhood Hits	131	Shared Neighborhood Hits	122
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

LAP2_MOUSE
θ value	0.000121331 (rank : 110)	NC score	0.248671 (rank : 159)
Query Neighborhood Hits	298	Target Neighborhood Hits	482	Shared Neighborhood Hits	107
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

PCLO_MOUSE
θ value	0.000121331 (rank : 111)	NC score	0.206479 (rank : 172)
Query Neighborhood Hits	298	Target Neighborhood Hits	2275	Shared Neighborhood Hits	169
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PDLI2_HUMAN
θ value	0.000121331 (rank : 112)	NC score	0.423480 (rank : 116)
Query Neighborhood Hits	298	Target Neighborhood Hits	245	Shared Neighborhood Hits	127
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

APBA3_HUMAN
θ value	0.000158464 (rank : 113)	NC score	0.453399 (rank : 100)
Query Neighborhood Hits	298	Target Neighborhood Hits	201	Shared Neighborhood Hits	144
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

RPGF6_HUMAN
θ value	0.000158464 (rank : 114)	NC score	0.381691 (rank : 125)
Query Neighborhood Hits	298	Target Neighborhood Hits	266	Shared Neighborhood Hits	162
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

PAR6G_HUMAN
θ value	0.00020696 (rank : 115)	NC score	0.444371 (rank : 106)
Query Neighborhood Hits	298	Target Neighborhood Hits	159	Shared Neighborhood Hits	117
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

MPP3_HUMAN
θ value	0.000270298 (rank : 116)	NC score	0.435244 (rank : 110)
Query Neighborhood Hits	298	Target Neighborhood Hits	171	Shared Neighborhood Hits	135
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

MPP3_MOUSE
θ value	0.000270298 (rank : 117)	NC score	0.439465 (rank : 108)
Query Neighborhood Hits	298	Target Neighborhood Hits	165	Shared Neighborhood Hits	134
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

PAR6G_MOUSE
θ value	0.000270298 (rank : 118)	NC score	0.444611 (rank : 104)
Query Neighborhood Hits	298	Target Neighborhood Hits	121	Shared Neighborhood Hits	115
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

RGS12_HUMAN
θ value	0.000270298 (rank : 119)	NC score	0.302463 (rank : 141)
Query Neighborhood Hits	298	Target Neighborhood Hits	333	Shared Neighborhood Hits	135
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

RIMS1_HUMAN
θ value	0.000270298 (rank : 120)	NC score	0.278898 (rank : 146)
Query Neighborhood Hits	298	Target Neighborhood Hits	437	Shared Neighborhood Hits	131
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

PDLI5_MOUSE
θ value	0.00035302 (rank : 121)	NC score	0.225591 (rank : 166)
Query Neighborhood Hits	298	Target Neighborhood Hits	287	Shared Neighborhood Hits	114
SwissProt Accessions	Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2	Gene names	Pdlim5, Enh
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

APBA3_MOUSE
θ value	0.000461057 (rank : 122)	NC score	0.424694 (rank : 115)
Query Neighborhood Hits	298	Target Neighborhood Hits	174	Shared Neighborhood Hits	138
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

MY18A_HUMAN
θ value	0.000461057 (rank : 123)	NC score	0.081385 (rank : 194)
Query Neighborhood Hits	298	Target Neighborhood Hits	1929	Shared Neighborhood Hits	156
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

PDLI5_HUMAN
θ value	0.000461057 (rank : 124)	NC score	0.224849 (rank : 167)
Query Neighborhood Hits	298	Target Neighborhood Hits	322	Shared Neighborhood Hits	115
SwissProt Accessions	Q96HC4, O60705	Gene names	PDLIM5, ENH
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

MPP4_HUMAN
θ value	0.000602161 (rank : 125)	NC score	0.473073 (rank : 92)
Query Neighborhood Hits	298	Target Neighborhood Hits	205	Shared Neighborhood Hits	141
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

PSCBP_MOUSE
θ value	0.000602161 (rank : 126)	NC score	0.405221 (rank : 119)
Query Neighborhood Hits	298	Target Neighborhood Hits	118	Shared Neighborhood Hits	112
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

LDB3_HUMAN
θ value	0.000786445 (rank : 127)	NC score	0.214011 (rank : 171)
Query Neighborhood Hits	298	Target Neighborhood Hits	497	Shared Neighborhood Hits	111
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

LDB3_MOUSE
θ value	0.000786445 (rank : 128)	NC score	0.216734 (rank : 170)
Query Neighborhood Hits	298	Target Neighborhood Hits	510	Shared Neighborhood Hits	109
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

MPP4_MOUSE
θ value	0.000786445 (rank : 129)	NC score	0.430903 (rank : 114)
Query Neighborhood Hits	298	Target Neighborhood Hits	188	Shared Neighborhood Hits	121
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

SYP2L_HUMAN
θ value	0.000786445 (rank : 130)	NC score	0.344336 (rank : 129)
Query Neighborhood Hits	298	Target Neighborhood Hits	400	Shared Neighborhood Hits	123
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

CSKP_MOUSE
θ value	0.00102713 (rank : 131)	NC score	0.129816 (rank : 185)
Query Neighborhood Hits	298	Target Neighborhood Hits	1027	Shared Neighborhood Hits	127
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

GIPC1_MOUSE
θ value	0.00102713 (rank : 132)	NC score	0.296384 (rank : 142)
Query Neighborhood Hits	298	Target Neighborhood Hits	92	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Z0G0	Gene names	Gipc1, Gipc, Rgs19ip1, Semcap1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Synectin) (SemaF cytoplasmic domain-associated protein 1) (SEMCAP-1).

MPP5_HUMAN
θ value	0.00102713 (rank : 133)	NC score	0.444557 (rank : 105)
Query Neighborhood Hits	298	Target Neighborhood Hits	231	Shared Neighborhood Hits	140
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	0.00102713 (rank : 134)	NC score	0.442461 (rank : 107)
Query Neighborhood Hits	298	Target Neighborhood Hits	226	Shared Neighborhood Hits	140
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

MPP6_HUMAN
θ value	0.00102713 (rank : 135)	NC score	0.338868 (rank : 131)
Query Neighborhood Hits	298	Target Neighborhood Hits	180	Shared Neighborhood Hits	93
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

NOS1_HUMAN
θ value	0.00102713 (rank : 136)	NC score	0.328947 (rank : 133)
Query Neighborhood Hits	298	Target Neighborhood Hits	218	Shared Neighborhood Hits	140
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

PSCBP_HUMAN
θ value	0.00102713 (rank : 137)	NC score	0.374863 (rank : 126)
Query Neighborhood Hits	298	Target Neighborhood Hits	123	Shared Neighborhood Hits	114
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

ARHGC_HUMAN
θ value	0.00134147 (rank : 138)	NC score	0.308545 (rank : 139)
Query Neighborhood Hits	298	Target Neighborhood Hits	351	Shared Neighborhood Hits	145
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

MAST1_MOUSE
θ value	0.00134147 (rank : 139)	NC score	0.065839 (rank : 207)
Query Neighborhood Hits	298	Target Neighborhood Hits	1123	Shared Neighborhood Hits	129
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST4_HUMAN
θ value	0.00134147 (rank : 140)	NC score	0.069079 (rank : 203)
Query Neighborhood Hits	298	Target Neighborhood Hits	1804	Shared Neighborhood Hits	153
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

PDLI2_MOUSE
θ value	0.00134147 (rank : 141)	NC score	0.384959 (rank : 124)
Query Neighborhood Hits	298	Target Neighborhood Hits	220	Shared Neighborhood Hits	120
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

RHPN1_MOUSE
θ value	0.00134147 (rank : 142)	NC score	0.350524 (rank : 128)
Query Neighborhood Hits	298	Target Neighborhood Hits	154	Shared Neighborhood Hits	132
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

ARHGC_MOUSE
θ value	0.00175202 (rank : 143)	NC score	0.305194 (rank : 140)
Query Neighborhood Hits	298	Target Neighborhood Hits	344	Shared Neighborhood Hits	151
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

CNKR2_HUMAN
θ value	0.00175202 (rank : 144)	NC score	0.172931 (rank : 179)
Query Neighborhood Hits	298	Target Neighborhood Hits	197	Shared Neighborhood Hits	55
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	0.00175202 (rank : 145)	NC score	0.173039 (rank : 178)
Query Neighborhood Hits	298	Target Neighborhood Hits	197	Shared Neighborhood Hits	55
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

GIPC1_HUMAN
θ value	0.00175202 (rank : 146)	NC score	0.283740 (rank : 145)
Query Neighborhood Hits	298	Target Neighborhood Hits	91	Shared Neighborhood Hits	88
SwissProt Accessions	O14908, Q9BTC9	Gene names	GIPC1, C19orf3, GIPC, RGS19IP1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Tax interaction protein 2) (TIP-2).

PTN4_HUMAN
θ value	0.00175202 (rank : 147)	NC score	0.161878 (rank : 181)
Query Neighborhood Hits	298	Target Neighborhood Hits	303	Shared Neighborhood Hits	121
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

MAST1_HUMAN
θ value	0.00228821 (rank : 148)	NC score	0.064076 (rank : 210)
Query Neighborhood Hits	298	Target Neighborhood Hits	1146	Shared Neighborhood Hits	134
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MPP6_MOUSE
θ value	0.00228821 (rank : 149)	NC score	0.342634 (rank : 130)
Query Neighborhood Hits	298	Target Neighborhood Hits	187	Shared Neighborhood Hits	97
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

CSKP_HUMAN
θ value	0.00298849 (rank : 150)	NC score	0.132784 (rank : 184)
Query Neighborhood Hits	298	Target Neighborhood Hits	1022	Shared Neighborhood Hits	127
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

RPGF2_HUMAN
θ value	0.00298849 (rank : 151)	NC score	0.324179 (rank : 138)
Query Neighborhood Hits	298	Target Neighborhood Hits	242	Shared Neighborhood Hits	150
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

TX1B3_HUMAN
θ value	0.00298849 (rank : 152)	NC score	0.640136 (rank : 54)
Query Neighborhood Hits	298	Target Neighborhood Hits	161	Shared Neighborhood Hits	156
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
θ value	0.00298849 (rank : 153)	NC score	0.634498 (rank : 56)
Query Neighborhood Hits	298	Target Neighborhood Hits	158	Shared Neighborhood Hits	153
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

GIPC2_HUMAN
θ value	0.00390308 (rank : 154)	NC score	0.250256 (rank : 158)
Query Neighborhood Hits	298	Target Neighborhood Hits	93	Shared Neighborhood Hits	92
SwissProt Accessions	Q8TF65, Q8IYD3, Q9NXS7	Gene names	GIPC2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2.

PDLI4_HUMAN
θ value	0.00390308 (rank : 155)	NC score	0.269305 (rank : 152)
Query Neighborhood Hits	298	Target Neighborhood Hits	245	Shared Neighborhood Hits	109
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

GRASP_MOUSE
θ value	0.00509761 (rank : 156)	NC score	0.412086 (rank : 118)
Query Neighborhood Hits	298	Target Neighborhood Hits	131	Shared Neighborhood Hits	117
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

PDLI4_MOUSE
θ value	0.00509761 (rank : 157)	NC score	0.270130 (rank : 151)
Query Neighborhood Hits	298	Target Neighborhood Hits	233	Shared Neighborhood Hits	111
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

RHPN1_HUMAN
θ value	0.00509761 (rank : 158)	NC score	0.326013 (rank : 136)
Query Neighborhood Hits	298	Target Neighborhood Hits	158	Shared Neighborhood Hits	126
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

ARHGB_HUMAN
θ value	0.00665767 (rank : 159)	NC score	0.324747 (rank : 137)
Query Neighborhood Hits	298	Target Neighborhood Hits	375	Shared Neighborhood Hits	163
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

GRASP_HUMAN
θ value	0.00665767 (rank : 160)	NC score	0.419014 (rank : 117)
Query Neighborhood Hits	298	Target Neighborhood Hits	147	Shared Neighborhood Hits	119
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

NOS1_MOUSE
θ value	0.00665767 (rank : 161)	NC score	0.291723 (rank : 144)
Query Neighborhood Hits	298	Target Neighborhood Hits	155	Shared Neighborhood Hits	116
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

GIPC3_HUMAN
θ value	0.0113563 (rank : 162)	NC score	0.182373 (rank : 176)
Query Neighborhood Hits	298	Target Neighborhood Hits	52	Shared Neighborhood Hits	51
SwissProt Accessions	Q8TF64, O75227	Gene names	GIPC3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3.

GIPC3_MOUSE
θ value	0.0113563 (rank : 163)	NC score	0.179375 (rank : 177)
Query Neighborhood Hits	298	Target Neighborhood Hits	53	Shared Neighborhood Hits	51
SwissProt Accessions	Q8R5M0	Gene names	Gipc3, Rgs19ip3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3 (Regulator of G-protein signaling 19-interacting protein 3).

PDZD6_HUMAN
θ value	0.0113563 (rank : 164)	NC score	0.223960 (rank : 168)
Query Neighborhood Hits	298	Target Neighborhood Hits	81	Shared Neighborhood Hits	55
SwissProt Accessions	Q9ULD6, Q4W5I8, Q86V55	Gene names	PDZD6, KIAA1284, PDZK6
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 6.

HTRA3_MOUSE
θ value	0.0252991 (rank : 165)	NC score	0.110253 (rank : 190)
Query Neighborhood Hits	298	Target Neighborhood Hits	156	Shared Neighborhood Hits	72
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

PRAX_HUMAN
θ value	0.0252991 (rank : 166)	NC score	0.122853 (rank : 186)
Query Neighborhood Hits	298	Target Neighborhood Hits	215	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BXM0, Q9BXL9, Q9HCF2	Gene names	PRX, KIAA1620
Domain Architecture
Description	Periaxin.

PRAX_MOUSE
θ value	0.0252991 (rank : 167)	NC score	0.145963 (rank : 183)
Query Neighborhood Hits	298	Target Neighborhood Hits	199	Shared Neighborhood Hits	44
SwissProt Accessions	O55103, O55104	Gene names	Prx
Domain Architecture
Description	Periaxin.

CDT1_HUMAN
θ value	0.0431538 (rank : 168)	NC score	0.039657 (rank : 240)
Query Neighborhood Hits	298	Target Neighborhood Hits	92	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H211, Q86XX9, Q96CJ5, Q96GK5, Q96H67, Q96HE6, Q9BWM0	Gene names	CDT1
Domain Architecture	No domain graphic available
Description	DNA replication factor Cdt1 (Double parked homolog) (DUP).

SHAN1_HUMAN
θ value	0.0563607 (rank : 169)	NC score	0.194368 (rank : 173)
Query Neighborhood Hits	298	Target Neighborhood Hits	1041	Shared Neighborhood Hits	156
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

EM55_HUMAN
θ value	0.0736092 (rank : 170)	NC score	0.389185 (rank : 120)
Query Neighborhood Hits	298	Target Neighborhood Hits	228	Shared Neighborhood Hits	128
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

LIMK2_MOUSE
θ value	0.0736092 (rank : 171)	NC score	0.036783 (rank : 242)
Query Neighborhood Hits	298	Target Neighborhood Hits	998	Shared Neighborhood Hits	73
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

SDCB2_HUMAN
θ value	0.0736092 (rank : 172)	NC score	0.332474 (rank : 132)
Query Neighborhood Hits	298	Target Neighborhood Hits	121	Shared Neighborhood Hits	114
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

SDCB2_MOUSE
θ value	0.0736092 (rank : 173)	NC score	0.352903 (rank : 127)
Query Neighborhood Hits	298	Target Neighborhood Hits	118	Shared Neighborhood Hits	111
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

PTN3_HUMAN
θ value	0.0961366 (rank : 174)	NC score	0.153721 (rank : 182)
Query Neighborhood Hits	298	Target Neighborhood Hits	258	Shared Neighborhood Hits	114
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

EM55_MOUSE
θ value	0.125558 (rank : 175)	NC score	0.385158 (rank : 123)
Query Neighborhood Hits	298	Target Neighborhood Hits	221	Shared Neighborhood Hits	126
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

LIMK2_HUMAN
θ value	0.125558 (rank : 176)	NC score	0.033733 (rank : 244)
Query Neighborhood Hits	298	Target Neighborhood Hits	986	Shared Neighborhood Hits	75
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

ELK4_MOUSE
θ value	0.163984 (rank : 177)	NC score	0.013042 (rank : 273)
Query Neighborhood Hits	298	Target Neighborhood Hits	107	Shared Neighborhood Hits	5
SwissProt Accessions	P41158	Gene names	Elk4, Sap1
Domain Architecture
Description	ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1).

MAST3_HUMAN
θ value	0.163984 (rank : 178)	NC score	0.064500 (rank : 209)
Query Neighborhood Hits	298	Target Neighborhood Hits	1128	Shared Neighborhood Hits	128
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

SHAN2_HUMAN
θ value	0.163984 (rank : 179)	NC score	0.295215 (rank : 143)
Query Neighborhood Hits	298	Target Neighborhood Hits	346	Shared Neighborhood Hits	128
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

MAST2_HUMAN
θ value	0.21417 (rank : 180)	NC score	0.063105 (rank : 211)
Query Neighborhood Hits	298	Target Neighborhood Hits	1189	Shared Neighborhood Hits	131
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

SHAN2_MOUSE
θ value	0.21417 (rank : 181)	NC score	0.267205 (rank : 153)
Query Neighborhood Hits	298	Target Neighborhood Hits	446	Shared Neighborhood Hits	124
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

DJC17_MOUSE
θ value	0.279714 (rank : 182)	NC score	0.018435 (rank : 260)
Query Neighborhood Hits	298	Target Neighborhood Hits	217	Shared Neighborhood Hits	6
SwissProt Accessions	Q91WT4, Q8C5R1	Gene names	Dnajc17
Domain Architecture	No domain graphic available
Description	DnaJ homolog subfamily C member 17.

PDLI7_HUMAN
θ value	0.279714 (rank : 183)	NC score	0.193026 (rank : 174)
Query Neighborhood Hits	298	Target Neighborhood Hits	547	Shared Neighborhood Hits	121
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

SDCB1_HUMAN
θ value	0.279714 (rank : 184)	NC score	0.386523 (rank : 122)
Query Neighborhood Hits	298	Target Neighborhood Hits	150	Shared Neighborhood Hits	143
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

SDCB1_MOUSE
θ value	0.279714 (rank : 185)	NC score	0.386980 (rank : 121)
Query Neighborhood Hits	298	Target Neighborhood Hits	144	Shared Neighborhood Hits	135
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

AFF1_MOUSE
θ value	0.365318 (rank : 186)	NC score	0.029533 (rank : 249)
Query Neighborhood Hits	298	Target Neighborhood Hits	351	Shared Neighborhood Hits	16
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

CAR14_HUMAN
θ value	0.365318 (rank : 187)	NC score	0.074491 (rank : 199)
Query Neighborhood Hits	298	Target Neighborhood Hits	449	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BXL6, Q9BVB5	Gene names	CARD14, CARMA2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2).

PDLI1_HUMAN
θ value	0.365318 (rank : 188)	NC score	0.254369 (rank : 157)
Query Neighborhood Hits	298	Target Neighborhood Hits	242	Shared Neighborhood Hits	102
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PDLI7_MOUSE
θ value	0.365318 (rank : 189)	NC score	0.184240 (rank : 175)
Query Neighborhood Hits	298	Target Neighborhood Hits	279	Shared Neighborhood Hits	101
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

GIPC2_MOUSE
θ value	0.47712 (rank : 190)	NC score	0.168836 (rank : 180)
Query Neighborhood Hits	298	Target Neighborhood Hits	71	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Z2H7, Q9CVG2	Gene names	Gipc2, Semcap2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2 (SemaF cytoplasmic domain- associated protein 2) (SEMCAP-2).

MAST2_MOUSE
θ value	0.47712 (rank : 191)	NC score	0.060717 (rank : 216)
Query Neighborhood Hits	298	Target Neighborhood Hits	1110	Shared Neighborhood Hits	128
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MUCDL_MOUSE
θ value	0.47712 (rank : 192)	NC score	0.020258 (rank : 258)
Query Neighborhood Hits	298	Target Neighborhood Hits	461	Shared Neighborhood Hits	30
SwissProt Accessions	Q8VHF2, Q8CEJ3, Q9D8I9	Gene names	Mucdhl
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

PDLI1_MOUSE
θ value	0.47712 (rank : 193)	NC score	0.258706 (rank : 155)
Query Neighborhood Hits	298	Target Neighborhood Hits	213	Shared Neighborhood Hits	102
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

APXL_HUMAN
θ value	0.62314 (rank : 194)	NC score	0.276435 (rank : 147)
Query Neighborhood Hits	298	Target Neighborhood Hits	553	Shared Neighborhood Hits	105
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

HTRA3_HUMAN
θ value	0.62314 (rank : 195)	NC score	0.099974 (rank : 192)
Query Neighborhood Hits	298	Target Neighborhood Hits	152	Shared Neighborhood Hits	63
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

MPP2_HUMAN
θ value	0.62314 (rank : 196)	NC score	0.326657 (rank : 135)
Query Neighborhood Hits	298	Target Neighborhood Hits	173	Shared Neighborhood Hits	94
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

APOA4_MOUSE
θ value	0.813845 (rank : 197)	NC score	0.010078 (rank : 284)
Query Neighborhood Hits	298	Target Neighborhood Hits	435	Shared Neighborhood Hits	10
SwissProt Accessions	P06728	Gene names	Apoa4
Domain Architecture
Description	Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV).

ATX2_HUMAN
θ value	0.813845 (rank : 198)	NC score	0.025070 (rank : 252)
Query Neighborhood Hits	298	Target Neighborhood Hits	375	Shared Neighborhood Hits	20
SwissProt Accessions	Q99700, Q6ZQZ7, Q99493	Gene names	ATXN2, ATX2, SCA2, TNRC13
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein).

ATX2_MOUSE
θ value	0.813845 (rank : 199)	NC score	0.020169 (rank : 259)
Query Neighborhood Hits	298	Target Neighborhood Hits	445	Shared Neighborhood Hits	20
SwissProt Accessions	O70305, P97421	Gene names	Atxn2, Atx2, Sca2
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein homolog).

LIMK1_HUMAN
θ value	0.813845 (rank : 200)	NC score	0.032936 (rank : 245)
Query Neighborhood Hits	298	Target Neighborhood Hits	1005	Shared Neighborhood Hits	84
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
θ value	0.813845 (rank : 201)	NC score	0.031710 (rank : 247)
Query Neighborhood Hits	298	Target Neighborhood Hits	1008	Shared Neighborhood Hits	86
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

LMO7_HUMAN
θ value	0.813845 (rank : 202)	NC score	0.122595 (rank : 187)
Query Neighborhood Hits	298	Target Neighborhood Hits	507	Shared Neighborhood Hits	55
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

PI51A_HUMAN
θ value	0.813845 (rank : 203)	NC score	0.010255 (rank : 281)
Query Neighborhood Hits	298	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q99755, Q99754, Q99756	Gene names	PIP5K1A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I alpha) (PtdIns(4)P- 5-kinase alpha) (PIP5KIalpha) (68 kDa type I phosphatidylinositol-4- phosphate 5-kinase alpha).

SYNP2_MOUSE
θ value	0.813845 (rank : 204)	NC score	0.275226 (rank : 148)
Query Neighborhood Hits	298	Target Neighborhood Hits	252	Shared Neighborhood Hits	120
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

DJC17_HUMAN
θ value	1.06291 (rank : 205)	NC score	0.015959 (rank : 266)
Query Neighborhood Hits	298	Target Neighborhood Hits	335	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NVM6	Gene names	DNAJC17
Domain Architecture	No domain graphic available
Description	DnaJ homolog subfamily C member 17.

DPOLZ_MOUSE
θ value	1.06291 (rank : 206)	NC score	0.016312 (rank : 263)
Query Neighborhood Hits	298	Target Neighborhood Hits	169	Shared Neighborhood Hits	14
SwissProt Accessions	Q61493, Q9JMD6, Q9QWX6	Gene names	Rev3l, Polz, Sez4
Domain Architecture
Description	DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Seizure-related protein 4).

PER3_MOUSE
θ value	1.06291 (rank : 207)	NC score	0.010002 (rank : 285)
Query Neighborhood Hits	298	Target Neighborhood Hits	85	Shared Neighborhood Hits	3
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

PO121_MOUSE
θ value	1.06291 (rank : 208)	NC score	0.016143 (rank : 264)
Query Neighborhood Hits	298	Target Neighborhood Hits	345	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K3Z9, Q7TSH5	Gene names	Pom121, Nup121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa).

RNF25_HUMAN
θ value	1.06291 (rank : 209)	NC score	0.020922 (rank : 256)
Query Neighborhood Hits	298	Target Neighborhood Hits	163	Shared Neighborhood Hits	11
SwissProt Accessions	Q96BH1, Q9H874	Gene names	RNF25
Domain Architecture
Description	RING finger protein 25 (EC 6.3.2.-).

TENS1_HUMAN
θ value	1.06291 (rank : 210)	NC score	0.016061 (rank : 265)
Query Neighborhood Hits	298	Target Neighborhood Hits	400	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

TPPC4_HUMAN
θ value	1.06291 (rank : 211)	NC score	0.055288 (rank : 220)
Query Neighborhood Hits	298	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y296	Gene names	TRAPPC4, SBDN
Domain Architecture
Description	Trafficking protein particle complex subunit 4 (Synbindin) (TRS23 homolog) (Hematopoietic stem/progenitor cell protein 172).

TPPC4_MOUSE
θ value	1.06291 (rank : 212)	NC score	0.056397 (rank : 218)
Query Neighborhood Hits	298	Target Neighborhood Hits	11	Shared Neighborhood Hits	7
SwissProt Accessions	Q9ES56, Q9DB31	Gene names	Trappc4, Sbdn
Domain Architecture
Description	Trafficking protein particle complex subunit 4 (Synbindin) (TRS23 homolog).

MPP2_MOUSE
θ value	1.38821 (rank : 213)	NC score	0.327010 (rank : 134)
Query Neighborhood Hits	298	Target Neighborhood Hits	189	Shared Neighborhood Hits	99
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

SNUT1_HUMAN
θ value	1.38821 (rank : 214)	NC score	0.034325 (rank : 243)
Query Neighborhood Hits	298	Target Neighborhood Hits	129	Shared Neighborhood Hits	6
SwissProt Accessions	O43290, Q53GB5	Gene names	SART1
Domain Architecture	No domain graphic available
Description	U4/U6.U5 tri-snRNP-associated protein 1 (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (Squamous cell carcinoma antigen recognized by T cells 1) (SART-1) (hSART-1) (hSnu66).

K0310_HUMAN
θ value	1.81305 (rank : 215)	NC score	0.020902 (rank : 257)
Query Neighborhood Hits	298	Target Neighborhood Hits	420	Shared Neighborhood Hits	26
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

MAPK5_MOUSE
θ value	1.81305 (rank : 216)	NC score	0.004327 (rank : 309)
Query Neighborhood Hits	298	Target Neighborhood Hits	799	Shared Neighborhood Hits	18
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

PCLO_HUMAN
θ value	1.81305 (rank : 217)	NC score	0.036986 (rank : 241)
Query Neighborhood Hits	298	Target Neighborhood Hits	2046	Shared Neighborhood Hits	80
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PKD2_MOUSE
θ value	1.81305 (rank : 218)	NC score	0.009356 (rank : 288)
Query Neighborhood Hits	298	Target Neighborhood Hits	99	Shared Neighborhood Hits	6
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

TAF7_MOUSE
θ value	1.81305 (rank : 219)	NC score	0.031084 (rank : 248)
Query Neighborhood Hits	298	Target Neighborhood Hits	217	Shared Neighborhood Hits	7
SwissProt Accessions	Q9R1C0	Gene names	Taf7, Taf2f
Domain Architecture
Description	Transcription initiation factor TFIID subunit 7 (Transcription initiation factor TFIID 55 kDa subunit) (TAF(II)55) (TAFII-55) (TAFII55).

UBP42_HUMAN
θ value	1.81305 (rank : 220)	NC score	0.012644 (rank : 275)
Query Neighborhood Hits	298	Target Neighborhood Hits	445	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

AFF1_HUMAN
θ value	2.36792 (rank : 221)	NC score	0.032162 (rank : 246)
Query Neighborhood Hits	298	Target Neighborhood Hits	506	Shared Neighborhood Hits	25
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

CD68_HUMAN
θ value	2.36792 (rank : 222)	NC score	0.014012 (rank : 270)
Query Neighborhood Hits	298	Target Neighborhood Hits	67	Shared Neighborhood Hits	4
SwissProt Accessions	P34810, Q96BI7	Gene names	CD68
Domain Architecture
Description	Macrosialin precursor (GP110) (CD68 antigen).

HTRA1_HUMAN
θ value	2.36792 (rank : 223)	NC score	0.073318 (rank : 200)
Query Neighborhood Hits	298	Target Neighborhood Hits	155	Shared Neighborhood Hits	50
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

HTRA1_MOUSE
θ value	2.36792 (rank : 224)	NC score	0.072359 (rank : 201)
Query Neighborhood Hits	298	Target Neighborhood Hits	140	Shared Neighborhood Hits	50
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

PDYN_HUMAN
θ value	2.36792 (rank : 225)	NC score	0.015547 (rank : 267)
Query Neighborhood Hits	298	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	P01213	Gene names	PDYN
Domain Architecture
Description	Beta-neoendorphin-dynorphin precursor (Proenkephalin B) (Preprodynorphin) [Contains: Beta-neoendorphin; Dynorphin; Leu- enkephalin; Rimorphin; Leumorphin].

RP1L1_HUMAN
θ value	2.36792 (rank : 226)	NC score	0.023003 (rank : 254)
Query Neighborhood Hits	298	Target Neighborhood Hits	1072	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

SALL3_HUMAN
θ value	2.36792 (rank : 227)	NC score	-0.005411 (rank : 328)
Query Neighborhood Hits	298	Target Neighborhood Hits	1066	Shared Neighborhood Hits	22
SwissProt Accessions	Q9BXA9, Q9UGH1	Gene names	SALL3
Domain Architecture	No domain graphic available
Description	Sal-like protein 3 (Zinc finger protein SALL3) (hSALL3).

UN13A_HUMAN
θ value	2.36792 (rank : 228)	NC score	0.013984 (rank : 271)
Query Neighborhood Hits	298	Target Neighborhood Hits	285	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

D2HDH_HUMAN
θ value	3.0926 (rank : 229)	NC score	0.027117 (rank : 251)
Query Neighborhood Hits	298	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N465, Q6IQ24, Q8N5Q8	Gene names	D2HGDH, D2HGD
Domain Architecture	No domain graphic available
Description	D-2-hydroxyglutarate dehydrogenase, mitochondrial precursor (EC 1.1.99.-).

DDFL1_MOUSE
θ value	3.0926 (rank : 230)	NC score	0.001822 (rank : 318)
Query Neighborhood Hits	298	Target Neighborhood Hits	324	Shared Neighborhood Hits	5
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

NPHP3_MOUSE
θ value	3.0926 (rank : 231)	NC score	0.009136 (rank : 289)
Query Neighborhood Hits	298	Target Neighborhood Hits	335	Shared Neighborhood Hits	9
SwissProt Accessions	Q7TNH6, Q69Z39, Q8C798, Q8C7Z3, Q9D6D1	Gene names	Nphp3, Kiaa2000
Domain Architecture	No domain graphic available
Description	Nephrocystin-3.

NRX1A_HUMAN
θ value	3.0926 (rank : 232)	NC score	0.002438 (rank : 314)
Query Neighborhood Hits	298	Target Neighborhood Hits	170	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ULB1, O60323, Q53TJ9, Q53TQ1, Q9C079, Q9C080, Q9C081, Q9H3M2, Q9UDM6	Gene names	NRXN1, KIAA0578
Domain Architecture
Description	Neurexin-1-alpha precursor (Neurexin I-alpha).

PELP1_MOUSE
θ value	3.0926 (rank : 233)	NC score	0.012262 (rank : 277)
Query Neighborhood Hits	298	Target Neighborhood Hits	709	Shared Neighborhood Hits	23
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

PF21B_MOUSE
θ value	3.0926 (rank : 234)	NC score	0.008316 (rank : 291)
Query Neighborhood Hits	298	Target Neighborhood Hits	278	Shared Neighborhood Hits	19
SwissProt Accessions	Q8C966	Gene names	Phf21b
Domain Architecture	No domain graphic available
Description	PHD finger protein 21B.

SI1L1_HUMAN
θ value	3.0926 (rank : 235)	NC score	0.050523 (rank : 237)
Query Neighborhood Hits	298	Target Neighborhood Hits	162	Shared Neighborhood Hits	42
SwissProt Accessions	O43166, O95321, Q9UDU4, Q9UNU4	Gene names	SIPA1L1, E6TP1, KIAA0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1 (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6- targeted protein 1).

SI1L1_MOUSE
θ value	3.0926 (rank : 236)	NC score	0.050130 (rank : 238)
Query Neighborhood Hits	298	Target Neighborhood Hits	189	Shared Neighborhood Hits	44
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

SYNP2_HUMAN
θ value	3.0926 (rank : 237)	NC score	0.219445 (rank : 169)
Query Neighborhood Hits	298	Target Neighborhood Hits	323	Shared Neighborhood Hits	106
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

TAF3_MOUSE
θ value	3.0926 (rank : 238)	NC score	0.015376 (rank : 268)
Query Neighborhood Hits	298	Target Neighborhood Hits	463	Shared Neighborhood Hits	17
SwissProt Accessions	Q5HZG4, Q3U490, Q3UWX2, Q8BIU8, Q99JH4	Gene names	Taf3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

WDR22_MOUSE
θ value	3.0926 (rank : 239)	NC score	0.002203 (rank : 315)
Query Neighborhood Hits	298	Target Neighborhood Hits	302	Shared Neighborhood Hits	2
SwissProt Accessions	Q80T85, Q80VT3, Q80ZW6, Q8BIP8, Q8BVK5, Q8K0Q6	Gene names	Wdr22, Kiaa1824
Domain Architecture
Description	WD repeat protein 22.

ZN358_HUMAN
θ value	3.0926 (rank : 240)	NC score	-0.008847 (rank : 329)
Query Neighborhood Hits	298	Target Neighborhood Hits	840	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NW07, Q9BTM7	Gene names	ZNF358
Domain Architecture
Description	Zinc finger protein 358.

ANTOL_HUMAN
θ value	4.03905 (rank : 241)	NC score	0.013507 (rank : 272)
Query Neighborhood Hits	298	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q96GY3, O14557, Q7Z2T9	Gene names	ames=MSTP064
Domain Architecture	No domain graphic available
Description	Antolefinin.

CAMKV_HUMAN
θ value	4.03905 (rank : 242)	NC score	0.005651 (rank : 302)
Query Neighborhood Hits	298	Target Neighborhood Hits	1084	Shared Neighborhood Hits	39
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CAMKV_MOUSE
θ value	4.03905 (rank : 243)	NC score	0.004423 (rank : 308)
Query Neighborhood Hits	298	Target Neighborhood Hits	848	Shared Neighborhood Hits	24
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CAR14_MOUSE
θ value	4.03905 (rank : 244)	NC score	0.061629 (rank : 212)
Query Neighborhood Hits	298	Target Neighborhood Hits	526	Shared Neighborhood Hits	34
SwissProt Accessions	Q99KF0	Gene names	Card14, Bimp2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (Bcl10-interacting MAGUK protein 2) (Bimp2).

LRBA_HUMAN
θ value	4.03905 (rank : 245)	NC score	0.003625 (rank : 312)
Query Neighborhood Hits	298	Target Neighborhood Hits	196	Shared Neighborhood Hits	4
SwissProt Accessions	P50851, Q9H2U3, Q9H2U4	Gene names	LRBA, BGL, CDC4L, LBA
Domain Architecture
Description	Lipopolysaccharide-responsive and beige-like anchor protein (CDC4-like protein) (Beige-like protein).

MBD4_HUMAN
θ value	4.03905 (rank : 246)	NC score	0.010183 (rank : 282)
Query Neighborhood Hits	298	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	O95243, Q7Z4T3, Q96F09	Gene names	MBD4, MED1
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 4 (EC 3.2.2.-) (Methyl-CpG-binding protein MBD4) (Methyl-CpG-binding endonuclease 1) (Mismatch-specific DNA N-glycosylase).

PCDG6_HUMAN
θ value	4.03905 (rank : 247)	NC score	-0.002397 (rank : 326)
Query Neighborhood Hits	298	Target Neighborhood Hits	156	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y5G7, Q9Y5D1	Gene names	PCDHGA6
Domain Architecture
Description	Protocadherin gamma A6 precursor (PCDH-gamma-A6).

PSMD9_MOUSE
θ value	4.03905 (rank : 248)	NC score	0.075170 (rank : 198)
Query Neighborhood Hits	298	Target Neighborhood Hits	30	Shared Neighborhood Hits	22
SwissProt Accessions	Q9CR00, Q3TG66	Gene names	Psmd9
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27).

RAI14_MOUSE
θ value	4.03905 (rank : 249)	NC score	0.001978 (rank : 317)
Query Neighborhood Hits	298	Target Neighborhood Hits	1505	Shared Neighborhood Hits	35
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

SI1L2_HUMAN
θ value	4.03905 (rank : 250)	NC score	0.056702 (rank : 217)
Query Neighborhood Hits	298	Target Neighborhood Hits	131	Shared Neighborhood Hits	47
SwissProt Accessions	Q9P2F8, Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6	Gene names	SIPA1L2, KIAA1389
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

SI1L2_MOUSE
θ value	4.03905 (rank : 251)	NC score	0.054780 (rank : 221)
Query Neighborhood Hits	298	Target Neighborhood Hits	124	Shared Neighborhood Hits	47
SwissProt Accessions	Q80TE4, Q6PDY1	Gene names	Sipa1l2, Kiaa0545
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

SPTN5_HUMAN
θ value	4.03905 (rank : 252)	NC score	0.006579 (rank : 297)
Query Neighborhood Hits	298	Target Neighborhood Hits	674	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

ABL1_HUMAN
θ value	5.27518 (rank : 253)	NC score	-0.002523 (rank : 327)
Query Neighborhood Hits	298	Target Neighborhood Hits	1220	Shared Neighborhood Hits	31
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

CCDC4_HUMAN
θ value	5.27518 (rank : 254)	NC score	0.024668 (rank : 253)
Query Neighborhood Hits	298	Target Neighborhood Hits	104	Shared Neighborhood Hits	8
SwissProt Accessions	Q6ZU67, Q58A26, Q58A27	Gene names	CCDC4
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 4.

CJ006_HUMAN
θ value	5.27518 (rank : 255)	NC score	0.008710 (rank : 290)
Query Neighborhood Hits	298	Target Neighborhood Hits	122	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IX21, Q5W0L8, Q9NPE8	Gene names	C10orf6
Domain Architecture	No domain graphic available
Description	Protein C10orf6.

CN092_MOUSE
θ value	5.27518 (rank : 256)	NC score	0.006268 (rank : 299)
Query Neighborhood Hits	298	Target Neighborhood Hits	206	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BU11, Q80UI2, Q99PN9, Q9CS16	Gene names
Domain Architecture
Description	Epidermal Langerhans cell protein LCP1.

HSN2_MOUSE
θ value	5.27518 (rank : 257)	NC score	0.009979 (rank : 286)
Query Neighborhood Hits	298	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q6IFS6	Gene names	Hsn2
Domain Architecture	No domain graphic available
Description	Protein HSN2 precursor.

K0082_MOUSE
θ value	5.27518 (rank : 258)	NC score	0.016974 (rank : 262)
Query Neighborhood Hits	298	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q9DBC3, Q3U3G5, Q3U7Y9, Q6A0D5, Q8C7V0	Gene names	Kiaa0082
Domain Architecture	No domain graphic available
Description	Protein KIAA0082.

K1688_MOUSE
θ value	5.27518 (rank : 259)	NC score	0.010164 (rank : 283)
Query Neighborhood Hits	298	Target Neighborhood Hits	188	Shared Neighborhood Hits	11
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

MUC2_HUMAN
θ value	5.27518 (rank : 260)	NC score	0.004767 (rank : 306)
Query Neighborhood Hits	298	Target Neighborhood Hits	906	Shared Neighborhood Hits	31
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

PININ_HUMAN
θ value	5.27518 (rank : 261)	NC score	0.014167 (rank : 269)
Query Neighborhood Hits	298	Target Neighborhood Hits	753	Shared Neighborhood Hits	25
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

PKD1_HUMAN
θ value	5.27518 (rank : 262)	NC score	0.001609 (rank : 319)
Query Neighborhood Hits	298	Target Neighborhood Hits	387	Shared Neighborhood Hits	6
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

PLCD1_MOUSE
θ value	5.27518 (rank : 263)	NC score	0.007617 (rank : 292)
Query Neighborhood Hits	298	Target Neighborhood Hits	106	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

PO2F1_HUMAN
θ value	5.27518 (rank : 264)	NC score	0.000946 (rank : 324)
Query Neighborhood Hits	298	Target Neighborhood Hits	426	Shared Neighborhood Hits	8
SwissProt Accessions	P14859, Q5TBT7, Q6PK46, Q8NEU9, Q9BPV1	Gene names	POU2F1, OCT1, OTF1
Domain Architecture
Description	POU domain, class 2, transcription factor 1 (Octamer-binding transcription factor 1) (Oct-1) (OTF-1) (NF-A1).

PO2F1_MOUSE
θ value	5.27518 (rank : 265)	NC score	0.001312 (rank : 321)
Query Neighborhood Hits	298	Target Neighborhood Hits	408	Shared Neighborhood Hits	6
SwissProt Accessions	P25425, Q61994, Q63891, Q6Y681, Q7TSD0, Q8BT04, Q8K570, Q99JH0, Q9WTZ4, Q9WTZ5, Q9WTZ6	Gene names	Pou2f1, Oct-1, Otf-1, Otf1
Domain Architecture
Description	POU domain, class 2, transcription factor 1 (Octamer-binding transcription factor 1) (Oct-1) (OTF-1) (NF-A1).

PUR1_HUMAN
θ value	5.27518 (rank : 266)	NC score	0.012097 (rank : 278)
Query Neighborhood Hits	298	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q06203	Gene names	PPAT, GPAT
Domain Architecture
Description	Amidophosphoribosyltransferase precursor (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (GPAT).

SNUT1_MOUSE
θ value	5.27518 (rank : 267)	NC score	0.028597 (rank : 250)
Query Neighborhood Hits	298	Target Neighborhood Hits	159	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z315, Q8K155, Q9R1I9, Q9R270	Gene names	Sart1, Haf
Domain Architecture	No domain graphic available
Description	U4/U6.U5 tri-snRNP-associated protein 1 (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (mSART-1) (Hypoxia- associated factor).

TAF3_HUMAN
θ value	5.27518 (rank : 268)	NC score	0.012710 (rank : 274)
Query Neighborhood Hits	298	Target Neighborhood Hits	568	Shared Neighborhood Hits	17
SwissProt Accessions	Q5VWG9, Q6GMS5, Q6P6B5, Q86VY6, Q9BQS9, Q9UFI8	Gene names	TAF3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

BCLX_MOUSE
θ value	6.88961 (rank : 269)	NC score	0.006531 (rank : 298)
Query Neighborhood Hits	298	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	Q64373, O35844, Q60657, Q60658, Q61338	Gene names	Bcl2l1, Bcl2l, Bclx
Domain Architecture
Description	Apoptosis regulator Bcl-X (Bcl-2-like 1 protein).

CHSS2_MOUSE
θ value	6.88961 (rank : 270)	NC score	0.004923 (rank : 305)
Query Neighborhood Hits	298	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q6IQX7	Gene names	Css2, D1Bwg1363e
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate synthase 2 (EC 2.4.1.175) (Glucuronosyl-N- acetylgalactosaminyl-proteoglycan 4-beta-N- acetylgalactosaminyltransferase II) (N-acetylgalactosaminyl- proteoglycan 3-beta-glucuronosyltransferase II) (EC 2.4.1.226) (Chondroitin glucuronyltransferase II) (N- acetylgalactosaminyltransferase).

CPXM2_MOUSE
θ value	6.88961 (rank : 271)	NC score	0.001053 (rank : 323)
Query Neighborhood Hits	298	Target Neighborhood Hits	58	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D2L5, O54860, Q8VDQ4	Gene names	Cpxm2, Cpx2
Domain Architecture
Description	Carboxypeptidase-like protein X2 precursor.

CSPG2_MOUSE
θ value	6.88961 (rank : 272)	NC score	0.001484 (rank : 320)
Query Neighborhood Hits	298	Target Neighborhood Hits	711	Shared Neighborhood Hits	22
SwissProt Accessions	Q62059, Q62058, Q9CUU0	Gene names	Cspg2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M).

DNJC1_HUMAN
θ value	6.88961 (rank : 273)	NC score	0.005071 (rank : 304)
Query Neighborhood Hits	298	Target Neighborhood Hits	127	Shared Neighborhood Hits	6
SwissProt Accessions	Q96KC8	Gene names	DNAJC1
Domain Architecture
Description	DnaJ homolog subfamily C member 1.

DPOLL_HUMAN
θ value	6.88961 (rank : 274)	NC score	0.005153 (rank : 303)
Query Neighborhood Hits	298	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UGP5, Q5JQP5, Q6NUM2, Q9HA10, Q9HB35	Gene names	POLL
Domain Architecture
Description	DNA polymerase lambda (EC 2.7.7.7) (EC 4.2.99.-) (Pol Lambda) (DNA polymerase kappa) (DNA polymerase beta-2) (Pol beta2).

IF35_MOUSE
θ value	6.88961 (rank : 275)	NC score	0.010518 (rank : 280)
Query Neighborhood Hits	298	Target Neighborhood Hits	210	Shared Neighborhood Hits	16
SwissProt Accessions	Q9DCH4	Gene names	Eif3s5
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 5 (eIF-3 epsilon) (eIF3 p47 subunit) (eIF3f).

LRC56_HUMAN
θ value	6.88961 (rank : 276)	NC score	0.010935 (rank : 279)
Query Neighborhood Hits	298	Target Neighborhood Hits	165	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IYG6, Q8N3Q4	Gene names	LRRC56
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 56.

PRG4_HUMAN
θ value	6.88961 (rank : 277)	NC score	0.017940 (rank : 261)
Query Neighborhood Hits	298	Target Neighborhood Hits	764	Shared Neighborhood Hits	34
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

RGS3_HUMAN
θ value	6.88961 (rank : 278)	NC score	0.068494 (rank : 206)
Query Neighborhood Hits	298	Target Neighborhood Hits	1375	Shared Neighborhood Hits	97
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

RGS3_MOUSE
θ value	6.88961 (rank : 279)	NC score	0.065696 (rank : 208)
Query Neighborhood Hits	298	Target Neighborhood Hits	1621	Shared Neighborhood Hits	104
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

UBP2L_MOUSE
θ value	6.88961 (rank : 280)	NC score	0.009733 (rank : 287)
Query Neighborhood Hits	298	Target Neighborhood Hits	173	Shared Neighborhood Hits	12
SwissProt Accessions	Q80X50, Q8BIT6, Q8BIW4, Q8BJ01, Q8CIG7, Q8K102, Q9CRT6	Gene names	Ubap2l
Domain Architecture	No domain graphic available
Description	Ubiquitin-associated protein 2-like.

WASF1_HUMAN
θ value	6.88961 (rank : 281)	NC score	0.007193 (rank : 295)
Query Neighborhood Hits	298	Target Neighborhood Hits	260	Shared Neighborhood Hits	12
SwissProt Accessions	Q92558	Gene names	WASF1, KIAA0269, SCAR1, WAVE1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1).

WASF1_MOUSE
θ value	6.88961 (rank : 282)	NC score	0.007223 (rank : 294)
Query Neighborhood Hits	298	Target Neighborhood Hits	261	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R5H6, Q91W51, Q9ERQ9	Gene names	Wasf1, Wave1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1).

ZBT17_HUMAN
θ value	6.88961 (rank : 283)	NC score	-0.010098 (rank : 330)
Query Neighborhood Hits	298	Target Neighborhood Hits	925	Shared Neighborhood Hits	5
SwissProt Accessions	Q13105, Q15932, Q5JYB2, Q9NUC9	Gene names	ZBTB17, MIZ1, ZNF151
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 17 (Zinc finger protein 151) (Myc-interacting zinc finger protein) (Miz-1 protein).

ATP9A_MOUSE
θ value	8.99809 (rank : 284)	NC score	0.000040 (rank : 325)
Query Neighborhood Hits	298	Target Neighborhood Hits	61	Shared Neighborhood Hits	2
SwissProt Accessions	O70228, Q8VDI5, Q922L9	Gene names	Atp9a
Domain Architecture	No domain graphic available
Description	Probable phospholipid-transporting ATPase IIA (EC 3.6.3.1) (ATPase class II type 9A).

BCLX_HUMAN
θ value	8.99809 (rank : 285)	NC score	0.005773 (rank : 301)
Query Neighborhood Hits	298	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q07817, Q5TE65, Q92976	Gene names	BCL2L1, BCL2L, BCLX
Domain Architecture
Description	Apoptosis regulator Bcl-X (Bcl-2-like 1 protein).

CLC4K_MOUSE
θ value	8.99809 (rank : 286)	NC score	0.002704 (rank : 313)
Query Neighborhood Hits	298	Target Neighborhood Hits	165	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VBX4, Q8R442	Gene names	Cd207, Clec4k
Domain Architecture	No domain graphic available
Description	C-type lectin domain family 4 member K (Langerin) (CD207 antigen).

EPC2_HUMAN
θ value	8.99809 (rank : 287)	NC score	0.004457 (rank : 307)
Query Neighborhood Hits	298	Target Neighborhood Hits	58	Shared Neighborhood Hits	3
SwissProt Accessions	Q52LR7, Q7L9J1, Q96RR7, Q9NUT8, Q9NVR1, Q9UFM9	Gene names	EPC2
Domain Architecture	No domain graphic available
Description	Enhancer of polycomb homolog 2.

FA54A_MOUSE
θ value	8.99809 (rank : 288)	NC score	0.007568 (rank : 293)
Query Neighborhood Hits	298	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VED8	Gene names	Fam54a, Dufd1
Domain Architecture	No domain graphic available
Description	Protein FAM54A (DUF729 domain-containing protein 1).

GATA5_MOUSE
θ value	8.99809 (rank : 289)	NC score	0.004167 (rank : 310)
Query Neighborhood Hits	298	Target Neighborhood Hits	51	Shared Neighborhood Hits	6
SwissProt Accessions	P97489	Gene names	Gata5
Domain Architecture
Description	Transcription factor GATA-5 (GATA-binding factor 5).

MYH10_MOUSE
θ value	8.99809 (rank : 290)	NC score	0.007023 (rank : 296)
Query Neighborhood Hits	298	Target Neighborhood Hits	1612	Shared Neighborhood Hits	36
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

PDLI3_HUMAN
θ value	8.99809 (rank : 291)	NC score	0.256551 (rank : 156)
Query Neighborhood Hits	298	Target Neighborhood Hits	199	Shared Neighborhood Hits	108
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PPE2_MOUSE
θ value	8.99809 (rank : 292)	NC score	0.001235 (rank : 322)
Query Neighborhood Hits	298	Target Neighborhood Hits	112	Shared Neighborhood Hits	2
SwissProt Accessions	O35385	Gene names	Ppef2
Domain Architecture
Description	Serine/threonine-protein phosphatase with EF-hands 2 (EC 3.1.3.16) (PPEF-2).

RGMC_MOUSE
θ value	8.99809 (rank : 293)	NC score	0.003946 (rank : 311)
Query Neighborhood Hits	298	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q7TQ32, Q8CEU7, Q8K1D4, Q9D741	Gene names	Hfe2, Rgmc
Domain Architecture	No domain graphic available
Description	Hemojuvelin precursor (Hemochromatosis type 2 protein homolog) (RGM domain family member C).

SI1L3_HUMAN
θ value	8.99809 (rank : 294)	NC score	0.043356 (rank : 239)
Query Neighborhood Hits	298	Target Neighborhood Hits	305	Shared Neighborhood Hits	48
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

TCOF_HUMAN
θ value	8.99809 (rank : 295)	NC score	0.021660 (rank : 255)
Query Neighborhood Hits	298	Target Neighborhood Hits	543	Shared Neighborhood Hits	21
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

TNR1B_MOUSE
θ value	8.99809 (rank : 296)	NC score	0.001985 (rank : 316)
Query Neighborhood Hits	298	Target Neighborhood Hits	123	Shared Neighborhood Hits	4
SwissProt Accessions	P25119, O88734, P97893	Gene names	Tnfrsf1b, Tnfr-2, Tnfr2
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1B precursor (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (p75) (p80 TNF-alpha receptor).

TS101_MOUSE
θ value	8.99809 (rank : 297)	NC score	0.005796 (rank : 300)
Query Neighborhood Hits	298	Target Neighborhood Hits	312	Shared Neighborhood Hits	11
SwissProt Accessions	Q61187	Gene names	Tsg101
Domain Architecture
Description	Tumor susceptibility gene 101 protein.

ZC3H3_MOUSE
θ value	8.99809 (rank : 298)	NC score	0.012474 (rank : 276)
Query Neighborhood Hits	298	Target Neighborhood Hits	188	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CHP0, Q80X78	Gene names	Zc3h3, Kiaa0150, Zc3hdc3, Zfp623
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 3.

CACB1_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.052979 (rank : 224)
Query Neighborhood Hits	298	Target Neighborhood Hits	44	Shared Neighborhood Hits	22
SwissProt Accessions	Q02641, O15331, Q02639, Q02640, Q9C085	Gene names	CACNB1, CACNLB1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1).

CACB1_MOUSE
θ value	θ > 10 (rank : 300)	NC score	0.055356 (rank : 219)
Query Neighborhood Hits	298	Target Neighborhood Hits	46	Shared Neighborhood Hits	21
SwissProt Accessions	Q8R3Z5, O88517, Q7TPF2, Q8R3Z6, Q9EPT9	Gene names	Cacnb1, Cacnlb1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1).

CACB3_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.052804 (rank : 225)
Query Neighborhood Hits	298	Target Neighborhood Hits	45	Shared Neighborhood Hits	17
SwissProt Accessions	P54284, Q13913	Gene names	CACNB3, CACNLB3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3).

CACB3_MOUSE
θ value	θ > 10 (rank : 302)	NC score	0.052763 (rank : 227)
Query Neighborhood Hits	298	Target Neighborhood Hits	48	Shared Neighborhood Hits	18
SwissProt Accessions	P54285	Gene names	Cacnb3, Cacnlb3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3) (CCHB3).

CACB4_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.052781 (rank : 226)
Query Neighborhood Hits	298	Target Neighborhood Hits	47	Shared Neighborhood Hits	19
SwissProt Accessions	O00305, O60515, Q96L40	Gene names	CACNB4, CACNLB4
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4).

CACB4_MOUSE
θ value	θ > 10 (rank : 304)	NC score	0.051102 (rank : 234)
Query Neighborhood Hits	298	Target Neighborhood Hits	42	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R0S4, Q8BRN6, Q8CAJ9	Gene names	Cacnb4, Cacnlb4
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4).

CAR11_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.079471 (rank : 196)
Query Neighborhood Hits	298	Target Neighborhood Hits	690	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

FRMD1_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.051395 (rank : 231)
Query Neighborhood Hits	298	Target Neighborhood Hits	48	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N878, Q5SZU7, Q9UFB0	Gene names	FRMD1
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 1.

HTRA4_HUMAN
θ value	θ > 10 (rank : 307)	NC score	0.051154 (rank : 233)
Query Neighborhood Hits	298	Target Neighborhood Hits	119	Shared Neighborhood Hits	43
SwissProt Accessions	P83105, Q542Z4, Q6PF13	Gene names	HTRA4
Domain Architecture	No domain graphic available
Description	Probable serine protease HTRA4 precursor (EC 3.4.21.-).

KGUA_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.235950 (rank : 163)
Query Neighborhood Hits	298	Target Neighborhood Hits	41	Shared Neighborhood Hits	29
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KGUA_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.237305 (rank : 162)
Query Neighborhood Hits	298	Target Neighborhood Hits	45	Shared Neighborhood Hits	29
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

LRRC1_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.068821 (rank : 205)
Query Neighborhood Hits	298	Target Neighborhood Hits	282	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BTT6, Q9HAC0, Q9NVF1	Gene names	LRRC1, LANO
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 1 (LAP and no PDZ protein) (LANO adapter protein).

LRRC1_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.068970 (rank : 204)
Query Neighborhood Hits	298	Target Neighborhood Hits	281	Shared Neighborhood Hits	8
SwissProt Accessions	Q80VQ1, Q3UI50, Q8BKR1, Q8BUS9	Gene names	Lrrc1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 1.

PDLI3_MOUSE
θ value	θ > 10 (rank : 312)	NC score	0.234761 (rank : 164)
Query Neighborhood Hits	298	Target Neighborhood Hits	197	Shared Neighborhood Hits	103
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PDZD8_HUMAN
θ value	θ > 10 (rank : 313)	NC score	0.104451 (rank : 191)
Query Neighborhood Hits	298	Target Neighborhood Hits	185	Shared Neighborhood Hits	47
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PEX10_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.061415 (rank : 213)
Query Neighborhood Hits	298	Target Neighborhood Hits	255	Shared Neighborhood Hits	7
SwissProt Accessions	O60683, Q5T095, Q9BW90	Gene names	PEX10, RNF69
Domain Architecture
Description	Peroxisome assembly protein 10 (Peroxin-10) (Peroxisome biogenesis factor 10) (RING finger protein 69).

PSMD9_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.071225 (rank : 202)
Query Neighborhood Hits	298	Target Neighborhood Hits	36	Shared Neighborhood Hits	22
SwissProt Accessions	O00233, Q9BQ42	Gene names	PSMD9
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27).

RAG1_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.050526 (rank : 236)
Query Neighborhood Hits	298	Target Neighborhood Hits	203	Shared Neighborhood Hits	8
SwissProt Accessions	P15918, Q8NER2	Gene names	RAG1, RNF74
Domain Architecture
Description	V(D)J recombination-activating protein 1 (RAG-1) (RING finger protein 74).

RAIN_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.051798 (rank : 229)
Query Neighborhood Hits	298	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	Q5U651, Q6U676	Gene names	RASIP1
Domain Architecture	No domain graphic available
Description	Ras-interacting protein 1 (Rain).

RAIN_MOUSE
θ value	θ > 10 (rank : 318)	NC score	0.050804 (rank : 235)
Query Neighborhood Hits	298	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q3U0S6, Q6GQW4	Gene names	Rasip1
Domain Architecture	No domain graphic available
Description	Ras-interacting protein 1 (Rain).

RHPN2_MOUSE
θ value	θ > 10 (rank : 319)	NC score	0.080695 (rank : 195)
Query Neighborhood Hits	298	Target Neighborhood Hits	60	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BWR8, Q9DBN2	Gene names	Rhpn2
Domain Architecture	No domain graphic available
Description	Rhophilin-2 (GTP-Rho-binding protein 2).

RNF41_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.110492 (rank : 189)
Query Neighborhood Hits	298	Target Neighborhood Hits	226	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H4P4, O75598	Gene names	RNF41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

RNF41_MOUSE
θ value	θ > 10 (rank : 321)	NC score	0.110757 (rank : 188)
Query Neighborhood Hits	298	Target Neighborhood Hits	224	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BH75, Q8BGJ2, Q8BMC9, Q8VEA2, Q9CRK6, Q9D568	Gene names	Rnf41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

SAV1_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.061199 (rank : 214)
Query Neighborhood Hits	298	Target Neighborhood Hits	51	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
θ value	θ > 10 (rank : 323)	NC score	0.061179 (rank : 215)
Query Neighborhood Hits	298	Target Neighborhood Hits	48	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

SYP2L_MOUSE
θ value	θ > 10 (rank : 324)	NC score	0.229931 (rank : 165)
Query Neighborhood Hits	298	Target Neighborhood Hits	289	Shared Neighborhood Hits	100
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

TIAM1_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.077227 (rank : 197)
Query Neighborhood Hits	298	Target Neighborhood Hits	225	Shared Neighborhood Hits	64
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TRAF6_HUMAN
θ value	θ > 10 (rank : 326)	NC score	0.051727 (rank : 230)
Query Neighborhood Hits	298	Target Neighborhood Hits	267	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y4K3, Q8NEH5	Gene names	TRAF6, RNF85
Domain Architecture
Description	TNF receptor-associated factor 6 (Interleukin 1 signal transducer) (RING finger protein 85).

TRAF6_MOUSE
θ value	θ > 10 (rank : 327)	NC score	0.053241 (rank : 223)
Query Neighborhood Hits	298	Target Neighborhood Hits	255	Shared Neighborhood Hits	7
SwissProt Accessions	P70196, Q8BLV2	Gene names	Traf6
Domain Architecture
Description	TNF receptor-associated factor 6.

WWC1_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.053963 (rank : 222)
Query Neighborhood Hits	298	Target Neighborhood Hits	290	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
θ value	θ > 10 (rank : 329)	NC score	0.052094 (rank : 228)
Query Neighborhood Hits	298	Target Neighborhood Hits	290	Shared Neighborhood Hits	11
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

YAP1_MOUSE
θ value	θ > 10 (rank : 330)	NC score	0.051199 (rank : 232)
Query Neighborhood Hits	298	Target Neighborhood Hits	96	Shared Neighborhood Hits	10
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

Hits sorted by NC score

MPDZ_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	298	Target Neighborhood Hits	298	Shared Neighborhood Hits	298
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

MPDZ_HUMAN
NC score	0.993773 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	298	Target Neighborhood Hits	261	Shared Neighborhood Hits	220
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

INADL_HUMAN
NC score	0.958046 (rank : 3)	θ value	1.05253e-149 (rank : 4)
Query Neighborhood Hits	298	Target Neighborhood Hits	260	Shared Neighborhood Hits	198
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

INADL_MOUSE
NC score	0.956862 (rank : 4)	θ value	0 (rank : 1)
Query Neighborhood Hits	298	Target Neighborhood Hits	290	Shared Neighborhood Hits	203
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

LNX2_MOUSE
NC score	0.833689 (rank : 5)	θ value	3.84025e-59 (rank : 5)
Query Neighborhood Hits	298	Target Neighborhood Hits	407	Shared Neighborhood Hits	178
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

SYJ2B_HUMAN
NC score	0.833564 (rank : 6)	θ value	4.16044e-13 (rank : 48)
Query Neighborhood Hits	298	Target Neighborhood Hits	162	Shared Neighborhood Hits	160
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

LNX2_HUMAN
NC score	0.827292 (rank : 7)	θ value	1.15626e-55 (rank : 7)
Query Neighborhood Hits	298	Target Neighborhood Hits	389	Shared Neighborhood Hits	178
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

LNX1_MOUSE
NC score	0.824746 (rank : 8)	θ value	7.49467e-55 (rank : 8)
Query Neighborhood Hits	298	Target Neighborhood Hits	377	Shared Neighborhood Hits	179
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

LNX1_HUMAN
NC score	0.820285 (rank : 9)	θ value	1.78386e-56 (rank : 6)
Query Neighborhood Hits	298	Target Neighborhood Hits	379	Shared Neighborhood Hits	171
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

PAR3L_HUMAN
NC score	0.804569 (rank : 10)	θ value	5.42112e-21 (rank : 26)
Query Neighborhood Hits	298	Target Neighborhood Hits	297	Shared Neighborhood Hits	157
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

PARD3_MOUSE
NC score	0.793894 (rank : 11)	θ value	4.01107e-24 (rank : 23)
Query Neighborhood Hits	298	Target Neighborhood Hits	290	Shared Neighborhood Hits	167
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

PARD3_HUMAN
NC score	0.792355 (rank : 12)	θ value	3.39556e-23 (rank : 24)
Query Neighborhood Hits	298	Target Neighborhood Hits	312	Shared Neighborhood Hits	170
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

LIN7B_HUMAN
NC score	0.777028 (rank : 13)	θ value	4.16044e-13 (rank : 47)
Query Neighborhood Hits	298	Target Neighborhood Hits	200	Shared Neighborhood Hits	191
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

PDZD7_HUMAN
NC score	0.775972 (rank : 14)	θ value	6.00763e-12 (rank : 56)
Query Neighborhood Hits	298	Target Neighborhood Hits	181	Shared Neighborhood Hits	171
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

LIN7B_MOUSE
NC score	0.775072 (rank : 15)	θ value	5.43371e-13 (rank : 49)
Query Neighborhood Hits	298	Target Neighborhood Hits	200	Shared Neighborhood Hits	191
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

LIN7C_HUMAN
NC score	0.772522 (rank : 16)	θ value	1.58096e-12 (rank : 53)
Query Neighborhood Hits	298	Target Neighborhood Hits	198	Shared Neighborhood Hits	189
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
NC score	0.772522 (rank : 17)	θ value	1.58096e-12 (rank : 54)
Query Neighborhood Hits	298	Target Neighborhood Hits	198	Shared Neighborhood Hits	189
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

GRIP2_HUMAN
NC score	0.772382 (rank : 18)	θ value	7.0802e-21 (rank : 27)
Query Neighborhood Hits	298	Target Neighborhood Hits	256	Shared Neighborhood Hits	197
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

LIN7A_HUMAN
NC score	0.770517 (rank : 19)	θ value	4.16044e-13 (rank : 45)
Query Neighborhood Hits	298	Target Neighborhood Hits	193	Shared Neighborhood Hits	187
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7A_MOUSE
NC score	0.770506 (rank : 20)	θ value	4.16044e-13 (rank : 46)
Query Neighborhood Hits	298	Target Neighborhood Hits	193	Shared Neighborhood Hits	187
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

PDZD2_HUMAN
NC score	0.769436 (rank : 21)	θ value	4.14116e-29 (rank : 14)
Query Neighborhood Hits	298	Target Neighborhood Hits	772	Shared Neighborhood Hits	215
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

USH1C_HUMAN
NC score	0.766639 (rank : 22)	θ value	2.20605e-14 (rank : 43)
Query Neighborhood Hits	298	Target Neighborhood Hits	327	Shared Neighborhood Hits	193
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

DLG4_MOUSE
NC score	0.762646 (rank : 23)	θ value	3.3877e-31 (rank : 13)
Query Neighborhood Hits	298	Target Neighborhood Hits	282	Shared Neighborhood Hits	187
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_HUMAN
NC score	0.761526 (rank : 24)	θ value	2.59387e-31 (rank : 12)
Query Neighborhood Hits	298	Target Neighborhood Hits	286	Shared Neighborhood Hits	185
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

IL16_HUMAN
NC score	0.761358 (rank : 25)	θ value	4.29542e-18 (rank : 29)
Query Neighborhood Hits	298	Target Neighborhood Hits	207	Shared Neighborhood Hits	145
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

GRIP1_HUMAN
NC score	0.752856 (rank : 26)	θ value	1.16975e-15 (rank : 35)
Query Neighborhood Hits	298	Target Neighborhood Hits	231	Shared Neighborhood Hits	194
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

GRIP1_MOUSE
NC score	0.749224 (rank : 27)	θ value	3.40345e-15 (rank : 40)
Query Neighborhood Hits	298	Target Neighborhood Hits	241	Shared Neighborhood Hits	194
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

DLG3_MOUSE
NC score	0.748538 (rank : 28)	θ value	3.62785e-25 (rank : 18)
Query Neighborhood Hits	298	Target Neighborhood Hits	274	Shared Neighborhood Hits	185
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

DLG1_MOUSE
NC score	0.746163 (rank : 29)	θ value	1.57365e-28 (rank : 15)
Query Neighborhood Hits	298	Target Neighborhood Hits	285	Shared Neighborhood Hits	177
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

DLG1_HUMAN
NC score	0.746140 (rank : 30)	θ value	7.80994e-28 (rank : 16)
Query Neighborhood Hits	298	Target Neighborhood Hits	290	Shared Neighborhood Hits	179
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

DLG3_HUMAN
NC score	0.743816 (rank : 31)	θ value	3.07116e-24 (rank : 22)
Query Neighborhood Hits	298	Target Neighborhood Hits	269	Shared Neighborhood Hits	185
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG2_HUMAN
NC score	0.736618 (rank : 32)	θ value	1.05554e-24 (rank : 20)
Query Neighborhood Hits	298	Target Neighborhood Hits	279	Shared Neighborhood Hits	184
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG2_MOUSE
NC score	0.736614 (rank : 33)	θ value	1.80048e-24 (rank : 21)
Query Neighborhood Hits	298	Target Neighborhood Hits	271	Shared Neighborhood Hits	182
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

IL16_MOUSE
NC score	0.731211 (rank : 34)	θ value	1.52774e-15 (rank : 36)
Query Neighborhood Hits	298	Target Neighborhood Hits	189	Shared Neighborhood Hits	138
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

WHRN_HUMAN
NC score	0.729943 (rank : 35)	θ value	3.52202e-12 (rank : 55)
Query Neighborhood Hits	298	Target Neighborhood Hits	325	Shared Neighborhood Hits	196
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

WHRN_MOUSE
NC score	0.727742 (rank : 36)	θ value	5.43371e-13 (rank : 50)
Query Neighborhood Hits	298	Target Neighborhood Hits	412	Shared Neighborhood Hits	195
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

MAGI1_HUMAN
NC score	0.727146 (rank : 37)	θ value	1.62847e-25 (rank : 17)
Query Neighborhood Hits	298	Target Neighborhood Hits	388	Shared Neighborhood Hits	203
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI1_MOUSE
NC score	0.723935 (rank : 38)	θ value	1.42661e-21 (rank : 25)
Query Neighborhood Hits	298	Target Neighborhood Hits	403	Shared Neighborhood Hits	202
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

PDZD1_MOUSE
NC score	0.719589 (rank : 39)	θ value	9.56915e-18 (rank : 30)
Query Neighborhood Hits	298	Target Neighborhood Hits	191	Shared Neighborhood Hits	165
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

USH1C_MOUSE
NC score	0.713940 (rank : 40)	θ value	7.09661e-13 (rank : 51)
Query Neighborhood Hits	298	Target Neighborhood Hits	557	Shared Neighborhood Hits	200
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

PDZD1_HUMAN
NC score	0.707955 (rank : 41)	θ value	4.74913e-17 (rank : 32)
Query Neighborhood Hits	298	Target Neighborhood Hits	190	Shared Neighborhood Hits	165
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

MAGI2_MOUSE
NC score	0.696125 (rank : 42)	θ value	2.27762e-19 (rank : 28)
Query Neighborhood Hits	298	Target Neighborhood Hits	370	Shared Neighborhood Hits	196
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

PDZ11_HUMAN
NC score	0.695083 (rank : 43)	θ value	2.88788e-06 (rank : 91)
Query Neighborhood Hits	298	Target Neighborhood Hits	160	Shared Neighborhood Hits	152
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

MAGI2_HUMAN
NC score	0.695059 (rank : 44)	θ value	4.02038e-16 (rank : 34)
Query Neighborhood Hits	298	Target Neighborhood Hits	373	Shared Neighborhood Hits	196
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

PDZ11_MOUSE
NC score	0.694658 (rank : 45)	θ value	1.69304e-06 (rank : 87)
Query Neighborhood Hits	298	Target Neighborhood Hits	154	Shared Neighborhood Hits	145
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

NHERF_MOUSE
NC score	0.678900 (rank : 46)	θ value	3.89403e-11 (rank : 59)
Query Neighborhood Hits	298	Target Neighborhood Hits	195	Shared Neighborhood Hits	167
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

GOPC_MOUSE
NC score	0.668038 (rank : 47)	θ value	1.99992e-07 (rank : 80)
Query Neighborhood Hits	298	Target Neighborhood Hits	323	Shared Neighborhood Hits	174
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

NHRF2_HUMAN
NC score	0.664685 (rank : 48)	θ value	1.33837e-11 (rank : 57)
Query Neighborhood Hits	298	Target Neighborhood Hits	197	Shared Neighborhood Hits	177
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

GOPC_HUMAN
NC score	0.657413 (rank : 49)	θ value	1.99992e-07 (rank : 79)
Query Neighborhood Hits	298	Target Neighborhood Hits	377	Shared Neighborhood Hits	175
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

SNTG2_HUMAN
NC score	0.655960 (rank : 50)	θ value	1.9326e-10 (rank : 61)
Query Neighborhood Hits	298	Target Neighborhood Hits	191	Shared Neighborhood Hits	182
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

NHRF2_MOUSE
NC score	0.653606 (rank : 51)	θ value	1.47974e-10 (rank : 60)
Query Neighborhood Hits	298	Target Neighborhood Hits	194	Shared Neighborhood Hits	177
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

PDZD3_HUMAN
NC score	0.652404 (rank : 52)	θ value	5.62301e-10 (rank : 62)
Query Neighborhood Hits	298	Target Neighborhood Hits	180	Shared Neighborhood Hits	166
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

NHERF_HUMAN
NC score	0.650051 (rank : 53)	θ value	7.34386e-10 (rank : 63)
Query Neighborhood Hits	298	Target Neighborhood Hits	190	Shared Neighborhood Hits	166
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

TX1B3_HUMAN
NC score	0.640136 (rank : 54)	θ value	0.00298849 (rank : 152)
Query Neighborhood Hits	298	Target Neighborhood Hits	161	Shared Neighborhood Hits	156
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

PZRN4_HUMAN
NC score	0.635760 (rank : 55)	θ value	1.52774e-15 (rank : 37)
Query Neighborhood Hits	298	Target Neighborhood Hits	438	Shared Neighborhood Hits	154
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

TX1B3_MOUSE
NC score	0.634498 (rank : 56)	θ value	0.00298849 (rank : 153)
Query Neighborhood Hits	298	Target Neighborhood Hits	158	Shared Neighborhood Hits	153
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

PZRN3_MOUSE
NC score	0.629571 (rank : 57)	θ value	8.10077e-17 (rank : 33)
Query Neighborhood Hits	298	Target Neighborhood Hits	447	Shared Neighborhood Hits	156
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PDZD3_MOUSE
NC score	0.625838 (rank : 58)	θ value	6.87365e-08 (rank : 76)
Query Neighborhood Hits	298	Target Neighborhood Hits	171	Shared Neighborhood Hits	163
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

PZRN3_HUMAN
NC score	0.625608 (rank : 59)	θ value	3.63628e-17 (rank : 31)
Query Neighborhood Hits	298	Target Neighborhood Hits	461	Shared Neighborhood Hits	157
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

ZO3_MOUSE
NC score	0.624868 (rank : 60)	θ value	5.81887e-07 (rank : 85)
Query Neighborhood Hits	298	Target Neighborhood Hits	224	Shared Neighborhood Hits	184
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

ZO3_HUMAN
NC score	0.624529 (rank : 61)	θ value	6.87365e-08 (rank : 77)
Query Neighborhood Hits	298	Target Neighborhood Hits	219	Shared Neighborhood Hits	178
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

SNTB2_MOUSE
NC score	0.623085 (rank : 62)	θ value	8.11959e-09 (rank : 68)
Query Neighborhood Hits	298	Target Neighborhood Hits	181	Shared Neighborhood Hits	163
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

SNTB2_HUMAN
NC score	0.622223 (rank : 63)	θ value	1.38499e-08 (rank : 69)
Query Neighborhood Hits	298	Target Neighborhood Hits	180	Shared Neighborhood Hits	163
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

SNTG2_MOUSE
NC score	0.620162 (rank : 64)	θ value	1.80886e-08 (rank : 72)
Query Neighborhood Hits	298	Target Neighborhood Hits	176	Shared Neighborhood Hits	169
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SNTA1_HUMAN
NC score	0.618218 (rank : 65)	θ value	2.13673e-09 (rank : 64)
Query Neighborhood Hits	298	Target Neighborhood Hits	186	Shared Neighborhood Hits	168
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

ZO1_MOUSE
NC score	0.607698 (rank : 66)	θ value	1.09485e-13 (rank : 44)
Query Neighborhood Hits	298	Target Neighborhood Hits	453	Shared Neighborhood Hits	184
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

SNTG1_MOUSE
NC score	0.607380 (rank : 67)	θ value	4.0297e-08 (rank : 74)
Query Neighborhood Hits	298	Target Neighborhood Hits	179	Shared Neighborhood Hits	173
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTG1_HUMAN
NC score	0.606983 (rank : 68)	θ value	5.26297e-08 (rank : 75)
Query Neighborhood Hits	298	Target Neighborhood Hits	181	Shared Neighborhood Hits	174
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTA1_MOUSE
NC score	0.606937 (rank : 69)	θ value	3.08544e-08 (rank : 73)
Query Neighborhood Hits	298	Target Neighborhood Hits	170	Shared Neighborhood Hits	162
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

ZO1_HUMAN
NC score	0.600347 (rank : 70)	θ value	2.60593e-15 (rank : 39)
Query Neighborhood Hits	298	Target Neighborhood Hits	474	Shared Neighborhood Hits	180
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

SNTB1_HUMAN
NC score	0.591480 (rank : 71)	θ value	4.76016e-09 (rank : 67)
Query Neighborhood Hits	298	Target Neighborhood Hits	157	Shared Neighborhood Hits	152
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

SNTB1_MOUSE
NC score	0.588809 (rank : 72)	θ value	3.64472e-09 (rank : 66)
Query Neighborhood Hits	298	Target Neighborhood Hits	160	Shared Neighborhood Hits	150
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

K1849_HUMAN
NC score	0.579011 (rank : 73)	θ value	2.79066e-09 (rank : 65)
Query Neighborhood Hits	298	Target Neighborhood Hits	220	Shared Neighborhood Hits	143
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

ZO2_MOUSE
NC score	0.576521 (rank : 74)	θ value	7.59969e-07 (rank : 86)
Query Neighborhood Hits	298	Target Neighborhood Hits	296	Shared Neighborhood Hits	176
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZO2_HUMAN
NC score	0.573376 (rank : 75)	θ value	5.81887e-07 (rank : 84)
Query Neighborhood Hits	298	Target Neighborhood Hits	289	Shared Neighborhood Hits	172
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

K1849_MOUSE
NC score	0.566775 (rank : 76)	θ value	2.28291e-11 (rank : 58)
Query Neighborhood Hits	298	Target Neighborhood Hits	335	Shared Neighborhood Hits	154
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

LAP4_HUMAN
NC score	0.551118 (rank : 77)	θ value	6.37413e-38 (rank : 9)
Query Neighborhood Hits	298	Target Neighborhood Hits	608	Shared Neighborhood Hits	208
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

LAP4_MOUSE
NC score	0.545594 (rank : 78)	θ value	3.4976e-36 (rank : 10)
Query Neighborhood Hits	298	Target Neighborhood Hits	590	Shared Neighborhood Hits	207
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

AFAD_HUMAN
NC score	0.536095 (rank : 79)	θ value	1.2105e-12 (rank : 52)
Query Neighborhood Hits	298	Target Neighborhood Hits	689	Shared Neighborhood Hits	145
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

NEB1_HUMAN
NC score	0.508320 (rank : 80)	θ value	1.99529e-15 (rank : 38)
Query Neighborhood Hits	298	Target Neighborhood Hits	829	Shared Neighborhood Hits	146
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

PDZK4_HUMAN
NC score	0.496970 (rank : 81)	θ value	2.21117e-06 (rank : 88)
Query Neighborhood Hits	298	Target Neighborhood Hits	165	Shared Neighborhood Hits	121
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PDZK4_MOUSE
NC score	0.494957 (rank : 82)	θ value	8.40245e-06 (rank : 99)
Query Neighborhood Hits	298	Target Neighborhood Hits	165	Shared Neighborhood Hits	125
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PTN13_HUMAN
NC score	0.491549 (rank : 83)	θ value	2.26708e-35 (rank : 11)
Query Neighborhood Hits	298	Target Neighborhood Hits	471	Shared Neighborhood Hits	197
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

DVL3_HUMAN
NC score	0.483710 (rank : 84)	θ value	6.43352e-06 (rank : 97)
Query Neighborhood Hits	298	Target Neighborhood Hits	194	Shared Neighborhood Hits	116
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_MOUSE
NC score	0.483672 (rank : 85)	θ value	6.43352e-06 (rank : 98)
Query Neighborhood Hits	298	Target Neighborhood Hits	198	Shared Neighborhood Hits	116
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

APBA1_HUMAN
NC score	0.482143 (rank : 86)	θ value	1.99992e-07 (rank : 78)
Query Neighborhood Hits	298	Target Neighborhood Hits	325	Shared Neighborhood Hits	160
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

DVL1_HUMAN
NC score	0.480589 (rank : 87)	θ value	2.88788e-06 (rank : 89)
Query Neighborhood Hits	298	Target Neighborhood Hits	158	Shared Neighborhood Hits	119
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

NEB2_HUMAN
NC score	0.480127 (rank : 88)	θ value	9.90251e-15 (rank : 41)
Query Neighborhood Hits	298	Target Neighborhood Hits	883	Shared Neighborhood Hits	131
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

DVL1_MOUSE
NC score	0.477416 (rank : 89)	θ value	2.88788e-06 (rank : 90)
Query Neighborhood Hits	298	Target Neighborhood Hits	146	Shared Neighborhood Hits	117
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

PTN13_MOUSE
NC score	0.476514 (rank : 90)	θ value	6.18819e-25 (rank : 19)
Query Neighborhood Hits	298	Target Neighborhood Hits	426	Shared Neighborhood Hits	193
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

NEB2_MOUSE
NC score	0.474089 (rank : 91)	θ value	9.90251e-15 (rank : 42)
Query Neighborhood Hits	298	Target Neighborhood Hits	889	Shared Neighborhood Hits	132
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

MPP4_HUMAN
NC score	0.473073 (rank : 92)	θ value	0.000602161 (rank : 125)
Query Neighborhood Hits	298	Target Neighborhood Hits	205	Shared Neighborhood Hits	141
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

PICK1_MOUSE
NC score	0.470455 (rank : 93)	θ value	9.29e-05 (rank : 109)
Query Neighborhood Hits	298	Target Neighborhood Hits	131	Shared Neighborhood Hits	122
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PICK1_HUMAN
NC score	0.470035 (rank : 94)	θ value	9.29e-05 (rank : 108)
Query Neighborhood Hits	298	Target Neighborhood Hits	132	Shared Neighborhood Hits	122
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

APBA2_MOUSE
NC score	0.466494 (rank : 95)	θ value	3.41135e-07 (rank : 82)
Query Neighborhood Hits	298	Target Neighborhood Hits	219	Shared Neighborhood Hits	150
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_HUMAN
NC score	0.466176 (rank : 96)	θ value	3.41135e-07 (rank : 81)
Query Neighborhood Hits	298	Target Neighborhood Hits	220	Shared Neighborhood Hits	151
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

DVL1L_HUMAN
NC score	0.463466 (rank : 97)	θ value	6.43352e-06 (rank : 94)
Query Neighborhood Hits	298	Target Neighborhood Hits	146	Shared Neighborhood Hits	115
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

DVL2_HUMAN
NC score	0.461542 (rank : 98)	θ value	6.43352e-06 (rank : 95)
Query Neighborhood Hits	298	Target Neighborhood Hits	223	Shared Neighborhood Hits	117
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_MOUSE
NC score	0.461194 (rank : 99)	θ value	6.43352e-06 (rank : 96)
Query Neighborhood Hits	298	Target Neighborhood Hits	233	Shared Neighborhood Hits	114
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

APBA3_HUMAN
NC score	0.453399 (rank : 100)	θ value	0.000158464 (rank : 113)
Query Neighborhood Hits	298	Target Neighborhood Hits	201	Shared Neighborhood Hits	144
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

DLG5_HUMAN
NC score	0.451027 (rank : 101)	θ value	3.41135e-07 (rank : 83)
Query Neighborhood Hits	298	Target Neighborhood Hits	1088	Shared Neighborhood Hits	183
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

PAR6B_HUMAN
NC score	0.448343 (rank : 102)	θ value	4.1701e-05 (rank : 101)
Query Neighborhood Hits	298	Target Neighborhood Hits	126	Shared Neighborhood Hits	120
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6B_MOUSE
NC score	0.446083 (rank : 103)	θ value	9.29e-05 (rank : 107)
Query Neighborhood Hits	298	Target Neighborhood Hits	128	Shared Neighborhood Hits	121
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6G_MOUSE
NC score	0.444611 (rank : 104)	θ value	0.000270298 (rank : 118)
Query Neighborhood Hits	298	Target Neighborhood Hits	121	Shared Neighborhood Hits	115
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

MPP5_HUMAN
NC score	0.444557 (rank : 105)	θ value	0.00102713 (rank : 133)
Query Neighborhood Hits	298	Target Neighborhood Hits	231	Shared Neighborhood Hits	140
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

PAR6G_HUMAN
NC score	0.444371 (rank : 106)	θ value	0.00020696 (rank : 115)
Query Neighborhood Hits	298	Target Neighborhood Hits	159	Shared Neighborhood Hits	117
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

MPP5_MOUSE
NC score	0.442461 (rank : 107)	θ value	0.00102713 (rank : 134)
Query Neighborhood Hits	298	Target Neighborhood Hits	226	Shared Neighborhood Hits	140
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

MPP3_MOUSE
NC score	0.439465 (rank : 108)	θ value	0.000270298 (rank : 117)
Query Neighborhood Hits	298	Target Neighborhood Hits	165	Shared Neighborhood Hits	134
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

STXB4_HUMAN
NC score	0.435843 (rank : 109)	θ value	1.38499e-08 (rank : 70)
Query Neighborhood Hits	298	Target Neighborhood Hits	616	Shared Neighborhood Hits	107
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

MPP3_HUMAN
NC score	0.435244 (rank : 110)	θ value	0.000270298 (rank : 116)
Query Neighborhood Hits	298	Target Neighborhood Hits	171	Shared Neighborhood Hits	135
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

PAR6A_MOUSE
NC score	0.434139 (rank : 111)	θ value	5.44631e-05 (rank : 103)
Query Neighborhood Hits	298	Target Neighborhood Hits	115	Shared Neighborhood Hits	110
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

STXB4_MOUSE
NC score	0.433722 (rank : 112)	θ value	1.38499e-08 (rank : 71)
Query Neighborhood Hits	298	Target Neighborhood Hits	629	Shared Neighborhood Hits	101
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

PAR6A_HUMAN
NC score	0.433113 (rank : 113)	θ value	5.44631e-05 (rank : 102)
Query Neighborhood Hits	298	Target Neighborhood Hits	119	Shared Neighborhood Hits	110
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

MPP4_MOUSE
NC score	0.430903 (rank : 114)	θ value	0.000786445 (rank : 129)
Query Neighborhood Hits	298	Target Neighborhood Hits	188	Shared Neighborhood Hits	121
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

APBA3_MOUSE
NC score	0.424694 (rank : 115)	θ value	0.000461057 (rank : 122)
Query Neighborhood Hits	298	Target Neighborhood Hits	174	Shared Neighborhood Hits	138
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

PDLI2_HUMAN
NC score	0.423480 (rank : 116)	θ value	0.000121331 (rank : 112)
Query Neighborhood Hits	298	Target Neighborhood Hits	245	Shared Neighborhood Hits	127
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

GRASP_HUMAN
NC score	0.419014 (rank : 117)	θ value	0.00665767 (rank : 160)
Query Neighborhood Hits	298	Target Neighborhood Hits	147	Shared Neighborhood Hits	119
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

GRASP_MOUSE
NC score	0.412086 (rank : 118)	θ value	0.00509761 (rank : 156)
Query Neighborhood Hits	298	Target Neighborhood Hits	131	Shared Neighborhood Hits	117
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

PSCBP_MOUSE
NC score	0.405221 (rank : 119)	θ value	0.000602161 (rank : 126)
Query Neighborhood Hits	298	Target Neighborhood Hits	118	Shared Neighborhood Hits	112
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

EM55_HUMAN
NC score	0.389185 (rank : 120)	θ value	0.0736092 (rank : 170)
Query Neighborhood Hits	298	Target Neighborhood Hits	228	Shared Neighborhood Hits	128
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

SDCB1_MOUSE
NC score	0.386980 (rank : 121)	θ value	0.279714 (rank : 185)
Query Neighborhood Hits	298	Target Neighborhood Hits	144	Shared Neighborhood Hits	135
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

SDCB1_HUMAN
NC score	0.386523 (rank : 122)	θ value	0.279714 (rank : 184)
Query Neighborhood Hits	298	Target Neighborhood Hits	150	Shared Neighborhood Hits	143
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

EM55_MOUSE
NC score	0.385158 (rank : 123)	θ value	0.125558 (rank : 175)
Query Neighborhood Hits	298	Target Neighborhood Hits	221	Shared Neighborhood Hits	126
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

PDLI2_MOUSE
NC score	0.384959 (rank : 124)	θ value	0.00134147 (rank : 141)
Query Neighborhood Hits	298	Target Neighborhood Hits	220	Shared Neighborhood Hits	120
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

RPGF6_HUMAN
NC score	0.381691 (rank : 125)	θ value	0.000158464 (rank : 114)
Query Neighborhood Hits	298	Target Neighborhood Hits	266	Shared Neighborhood Hits	162
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

PSCBP_HUMAN
NC score	0.374863 (rank : 126)	θ value	0.00102713 (rank : 137)
Query Neighborhood Hits	298	Target Neighborhood Hits	123	Shared Neighborhood Hits	114
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

SDCB2_MOUSE
NC score	0.352903 (rank : 127)	θ value	0.0736092 (rank : 173)
Query Neighborhood Hits	298	Target Neighborhood Hits	118	Shared Neighborhood Hits	111
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

RHPN1_MOUSE
NC score	0.350524 (rank : 128)	θ value	0.00134147 (rank : 142)
Query Neighborhood Hits	298	Target Neighborhood Hits	154	Shared Neighborhood Hits	132
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

SYP2L_HUMAN
NC score	0.344336 (rank : 129)	θ value	0.000786445 (rank : 130)
Query Neighborhood Hits	298	Target Neighborhood Hits	400	Shared Neighborhood Hits	123
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

MPP6_MOUSE
NC score	0.342634 (rank : 130)	θ value	0.00228821 (rank : 149)
Query Neighborhood Hits	298	Target Neighborhood Hits	187	Shared Neighborhood Hits	97
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

MPP6_HUMAN
NC score	0.338868 (rank : 131)	θ value	0.00102713 (rank : 135)
Query Neighborhood Hits	298	Target Neighborhood Hits	180	Shared Neighborhood Hits	93
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

SDCB2_HUMAN
NC score	0.332474 (rank : 132)	θ value	0.0736092 (rank : 172)
Query Neighborhood Hits	298	Target Neighborhood Hits	121	Shared Neighborhood Hits	114
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

NOS1_HUMAN
NC score	0.328947 (rank : 133)	θ value	0.00102713 (rank : 136)
Query Neighborhood Hits	298	Target Neighborhood Hits	218	Shared Neighborhood Hits	140
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

MPP2_MOUSE
NC score	0.327010 (rank : 134)	θ value	1.38821 (rank : 213)
Query Neighborhood Hits	298	Target Neighborhood Hits	189	Shared Neighborhood Hits	99
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

MPP2_HUMAN
NC score	0.326657 (rank : 135)	θ value	0.62314 (rank : 196)
Query Neighborhood Hits	298	Target Neighborhood Hits	173	Shared Neighborhood Hits	94
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

RHPN1_HUMAN
NC score	0.326013 (rank : 136)	θ value	0.00509761 (rank : 158)
Query Neighborhood Hits	298	Target Neighborhood Hits	158	Shared Neighborhood Hits	126
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

ARHGB_HUMAN
NC score	0.324747 (rank : 137)	θ value	0.00665767 (rank : 159)
Query Neighborhood Hits	298	Target Neighborhood Hits	375	Shared Neighborhood Hits	163
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

RPGF2_HUMAN
NC score	0.324179 (rank : 138)	θ value	0.00298849 (rank : 151)
Query Neighborhood Hits	298	Target Neighborhood Hits	242	Shared Neighborhood Hits	150
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

ARHGC_HUMAN
NC score	0.308545 (rank : 139)	θ value	0.00134147 (rank : 138)
Query Neighborhood Hits	298	Target Neighborhood Hits	351	Shared Neighborhood Hits	145
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
NC score	0.305194 (rank : 140)	θ value	0.00175202 (rank : 143)
Query Neighborhood Hits	298	Target Neighborhood Hits	344	Shared Neighborhood Hits	151
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

RGS12_HUMAN
NC score	0.302463 (rank : 141)	θ value	0.000270298 (rank : 119)
Query Neighborhood Hits	298	Target Neighborhood Hits	333	Shared Neighborhood Hits	135
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

GIPC1_MOUSE
NC score	0.296384 (rank : 142)	θ value	0.00102713 (rank : 132)
Query Neighborhood Hits	298	Target Neighborhood Hits	92	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Z0G0	Gene names	Gipc1, Gipc, Rgs19ip1, Semcap1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Synectin) (SemaF cytoplasmic domain-associated protein 1) (SEMCAP-1).

SHAN2_HUMAN
NC score	0.295215 (rank : 143)	θ value	0.163984 (rank : 179)
Query Neighborhood Hits	298	Target Neighborhood Hits	346	Shared Neighborhood Hits	128
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

NOS1_MOUSE
NC score	0.291723 (rank : 144)	θ value	0.00665767 (rank : 161)
Query Neighborhood Hits	298	Target Neighborhood Hits	155	Shared Neighborhood Hits	116
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

GIPC1_HUMAN
NC score	0.283740 (rank : 145)	θ value	0.00175202 (rank : 146)
Query Neighborhood Hits	298	Target Neighborhood Hits	91	Shared Neighborhood Hits	88
SwissProt Accessions	O14908, Q9BTC9	Gene names	GIPC1, C19orf3, GIPC, RGS19IP1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Tax interaction protein 2) (TIP-2).

RIMS1_HUMAN
NC score	0.278898 (rank : 146)	θ value	0.000270298 (rank : 120)
Query Neighborhood Hits	298	Target Neighborhood Hits	437	Shared Neighborhood Hits	131
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

APXL_HUMAN
NC score	0.276435 (rank : 147)	θ value	0.62314 (rank : 194)
Query Neighborhood Hits	298	Target Neighborhood Hits	553	Shared Neighborhood Hits	105
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

SYNP2_MOUSE
NC score	0.275226 (rank : 148)	θ value	0.813845 (rank : 204)
Query Neighborhood Hits	298	Target Neighborhood Hits	252	Shared Neighborhood Hits	120
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

LRRC7_HUMAN
NC score	0.273253 (rank : 149)	θ value	3.77169e-06 (rank : 92)
Query Neighborhood Hits	298	Target Neighborhood Hits	423	Shared Neighborhood Hits	115
SwissProt Accessions	Q96NW7, Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2	Gene names	LRRC7, KIAA1365, LAP1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

LRRC7_MOUSE
NC score	0.272173 (rank : 150)	θ value	3.77169e-06 (rank : 93)
Query Neighborhood Hits	298	Target Neighborhood Hits	416	Shared Neighborhood Hits	113
SwissProt Accessions	Q80TE7	Gene names	Lrrc7, Kiaa1365, Lap1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

PDLI4_MOUSE
NC score	0.270130 (rank : 151)	θ value	0.00509761 (rank : 157)
Query Neighborhood Hits	298	Target Neighborhood Hits	233	Shared Neighborhood Hits	111
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PDLI4_HUMAN
NC score	0.269305 (rank : 152)	θ value	0.00390308 (rank : 155)
Query Neighborhood Hits	298	Target Neighborhood Hits	245	Shared Neighborhood Hits	109
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

SHAN2_MOUSE
NC score	0.267205 (rank : 153)	θ value	0.21417 (rank : 181)
Query Neighborhood Hits	298	Target Neighborhood Hits	446	Shared Neighborhood Hits	124
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

LAP2_HUMAN
NC score	0.260405 (rank : 154)	θ value	2.44474e-05 (rank : 100)
Query Neighborhood Hits	298	Target Neighborhood Hits	499	Shared Neighborhood Hits	110
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

PDLI1_MOUSE
NC score	0.258706 (rank : 155)	θ value	0.47712 (rank : 193)
Query Neighborhood Hits	298	Target Neighborhood Hits	213	Shared Neighborhood Hits	102
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PDLI3_HUMAN
NC score	0.256551 (rank : 156)	θ value	8.99809 (rank : 291)
Query Neighborhood Hits	298	Target Neighborhood Hits	199	Shared Neighborhood Hits	108
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PDLI1_HUMAN
NC score	0.254369 (rank : 157)	θ value	0.365318 (rank : 188)
Query Neighborhood Hits	298	Target Neighborhood Hits	242	Shared Neighborhood Hits	102
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

GIPC2_HUMAN
NC score	0.250256 (rank : 158)	θ value	0.00390308 (rank : 154)
Query Neighborhood Hits	298	Target Neighborhood Hits	93	Shared Neighborhood Hits	92
SwissProt Accessions	Q8TF65, Q8IYD3, Q9NXS7	Gene names	GIPC2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2.

LAP2_MOUSE
NC score	0.248671 (rank : 159)	θ value	0.000121331 (rank : 110)
Query Neighborhood Hits	298	Target Neighborhood Hits	482	Shared Neighborhood Hits	107
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

RIMS2_HUMAN
NC score	0.244690 (rank : 160)	θ value	5.44631e-05 (rank : 104)
Query Neighborhood Hits	298	Target Neighborhood Hits	342	Shared Neighborhood Hits	106
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
NC score	0.241684 (rank : 161)	θ value	5.44631e-05 (rank : 105)
Query Neighborhood Hits	298	Target Neighborhood Hits	376	Shared Neighborhood Hits	108
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

KGUA_MOUSE
NC score	0.237305 (rank : 162)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	298	Target Neighborhood Hits	45	Shared Neighborhood Hits	29
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KGUA_HUMAN
NC score	0.235950 (rank : 163)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	298	Target Neighborhood Hits	41	Shared Neighborhood Hits	29
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

PDLI3_MOUSE
NC score	0.234761 (rank : 164)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	298	Target Neighborhood Hits	197	Shared Neighborhood Hits	103
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

SYP2L_MOUSE
NC score	0.229931 (rank : 165)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	298	Target Neighborhood Hits	289	Shared Neighborhood Hits	100
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

PDLI5_MOUSE
NC score	0.225591 (rank : 166)	θ value	0.00035302 (rank : 121)
Query Neighborhood Hits	298	Target Neighborhood Hits	287	Shared Neighborhood Hits	114
SwissProt Accessions	Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2	Gene names	Pdlim5, Enh
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PDLI5_HUMAN
NC score	0.224849 (rank : 167)	θ value	0.000461057 (rank : 124)
Query Neighborhood Hits	298	Target Neighborhood Hits	322	Shared Neighborhood Hits	115
SwissProt Accessions	Q96HC4, O60705	Gene names	PDLIM5, ENH
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PDZD6_HUMAN
NC score	0.223960 (rank : 168)	θ value	0.0113563 (rank : 164)
Query Neighborhood Hits	298	Target Neighborhood Hits	81	Shared Neighborhood Hits	55
SwissProt Accessions	Q9ULD6, Q4W5I8, Q86V55	Gene names	PDZD6, KIAA1284, PDZK6
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 6.

SYNP2_HUMAN
NC score	0.219445 (rank : 169)	θ value	3.0926 (rank : 237)
Query Neighborhood Hits	298	Target Neighborhood Hits	323	Shared Neighborhood Hits	106
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

LDB3_MOUSE
NC score	0.216734 (rank : 170)	θ value	0.000786445 (rank : 128)
Query Neighborhood Hits	298	Target Neighborhood Hits	510	Shared Neighborhood Hits	109
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

LDB3_HUMAN
NC score	0.214011 (rank : 171)	θ value	0.000786445 (rank : 127)
Query Neighborhood Hits	298	Target Neighborhood Hits	497	Shared Neighborhood Hits	111
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

PCLO_MOUSE
NC score	0.206479 (rank : 172)	θ value	0.000121331 (rank : 111)
Query Neighborhood Hits	298	Target Neighborhood Hits	2275	Shared Neighborhood Hits	169
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

SHAN1_HUMAN
NC score	0.194368 (rank : 173)	θ value	0.0563607 (rank : 169)
Query Neighborhood Hits	298	Target Neighborhood Hits	1041	Shared Neighborhood Hits	156
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

PDLI7_HUMAN
NC score	0.193026 (rank : 174)	θ value	0.279714 (rank : 183)
Query Neighborhood Hits	298	Target Neighborhood Hits	547	Shared Neighborhood Hits	121
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PDLI7_MOUSE
NC score	0.184240 (rank : 175)	θ value	0.365318 (rank : 189)
Query Neighborhood Hits	298	Target Neighborhood Hits	279	Shared Neighborhood Hits	101
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

GIPC3_HUMAN
NC score	0.182373 (rank : 176)	θ value	0.0113563 (rank : 162)
Query Neighborhood Hits	298	Target Neighborhood Hits	52	Shared Neighborhood Hits	51
SwissProt Accessions	Q8TF64, O75227	Gene names	GIPC3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3.

GIPC3_MOUSE
NC score	0.179375 (rank : 177)	θ value	0.0113563 (rank : 163)
Query Neighborhood Hits	298	Target Neighborhood Hits	53	Shared Neighborhood Hits	51
SwissProt Accessions	Q8R5M0	Gene names	Gipc3, Rgs19ip3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3 (Regulator of G-protein signaling 19-interacting protein 3).

CNKR2_MOUSE
NC score	0.173039 (rank : 178)	θ value	0.00175202 (rank : 145)
Query Neighborhood Hits	298	Target Neighborhood Hits	197	Shared Neighborhood Hits	55
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.172931 (rank : 179)	θ value	0.00175202 (rank : 144)
Query Neighborhood Hits	298	Target Neighborhood Hits	197	Shared Neighborhood Hits	55
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

GIPC2_MOUSE
NC score	0.168836 (rank : 180)	θ value	0.47712 (rank : 190)
Query Neighborhood Hits	298	Target Neighborhood Hits	71	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Z2H7, Q9CVG2	Gene names	Gipc2, Semcap2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2 (SemaF cytoplasmic domain- associated protein 2) (SEMCAP-2).

PTN4_HUMAN
NC score	0.161878 (rank : 181)	θ value	0.00175202 (rank : 147)
Query Neighborhood Hits	298	Target Neighborhood Hits	303	Shared Neighborhood Hits	121
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

PTN3_HUMAN
NC score	0.153721 (rank : 182)	θ value	0.0961366 (rank : 174)
Query Neighborhood Hits	298	Target Neighborhood Hits	258	Shared Neighborhood Hits	114
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

PRAX_MOUSE
NC score	0.145963 (rank : 183)	θ value	0.0252991 (rank : 167)
Query Neighborhood Hits	298	Target Neighborhood Hits	199	Shared Neighborhood Hits	44
SwissProt Accessions	O55103, O55104	Gene names	Prx
Domain Architecture
Description	Periaxin.

CSKP_HUMAN
NC score	0.132784 (rank : 184)	θ value	0.00298849 (rank : 150)
Query Neighborhood Hits	298	Target Neighborhood Hits	1022	Shared Neighborhood Hits	127
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKP_MOUSE
NC score	0.129816 (rank : 185)	θ value	0.00102713 (rank : 131)
Query Neighborhood Hits	298	Target Neighborhood Hits	1027	Shared Neighborhood Hits	127
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

PRAX_HUMAN
NC score	0.122853 (rank : 186)	θ value	0.0252991 (rank : 166)
Query Neighborhood Hits	298	Target Neighborhood Hits	215	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BXM0, Q9BXL9, Q9HCF2	Gene names	PRX, KIAA1620
Domain Architecture
Description	Periaxin.

LMO7_HUMAN
NC score	0.122595 (rank : 187)	θ value	0.813845 (rank : 202)
Query Neighborhood Hits	298	Target Neighborhood Hits	507	Shared Neighborhood Hits	55
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

RNF41_MOUSE
NC score	0.110757 (rank : 188)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	298	Target Neighborhood Hits	224	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BH75, Q8BGJ2, Q8BMC9, Q8VEA2, Q9CRK6, Q9D568	Gene names	Rnf41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

RNF41_HUMAN
NC score	0.110492 (rank : 189)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	298	Target Neighborhood Hits	226	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H4P4, O75598	Gene names	RNF41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

HTRA3_MOUSE
NC score	0.110253 (rank : 190)	θ value	0.0252991 (rank : 165)
Query Neighborhood Hits	298	Target Neighborhood Hits	156	Shared Neighborhood Hits	72
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

PDZD8_HUMAN
NC score	0.104451 (rank : 191)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	298	Target Neighborhood Hits	185	Shared Neighborhood Hits	47
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

HTRA3_HUMAN
NC score	0.099974 (rank : 192)	θ value	0.62314 (rank : 195)
Query Neighborhood Hits	298	Target Neighborhood Hits	152	Shared Neighborhood Hits	63
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

MY18A_MOUSE
NC score	0.087217 (rank : 193)	θ value	9.29e-05 (rank : 106)
Query Neighborhood Hits	298	Target Neighborhood Hits	1989	Shared Neighborhood Hits	155
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MY18A_HUMAN
NC score	0.081385 (rank : 194)	θ value	0.000461057 (rank : 123)
Query Neighborhood Hits	298	Target Neighborhood Hits	1929	Shared Neighborhood Hits	156
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

RHPN2_MOUSE
NC score	0.080695 (rank : 195)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	298	Target Neighborhood Hits	60	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BWR8, Q9DBN2	Gene names	Rhpn2
Domain Architecture	No domain graphic available
Description	Rhophilin-2 (GTP-Rho-binding protein 2).

CAR11_HUMAN
NC score	0.079471 (rank : 196)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	298	Target Neighborhood Hits	690	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

TIAM1_HUMAN
NC score	0.077227 (rank : 197)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	298	Target Neighborhood Hits	225	Shared Neighborhood Hits	64
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

PSMD9_MOUSE
NC score	0.075170 (rank : 198)	θ value	4.03905 (rank : 248)
Query Neighborhood Hits	298	Target Neighborhood Hits	30	Shared Neighborhood Hits	22
SwissProt Accessions	Q9CR00, Q3TG66	Gene names	Psmd9
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27).

CAR14_HUMAN
NC score	0.074491 (rank : 199)	θ value	0.365318 (rank : 187)
Query Neighborhood Hits	298	Target Neighborhood Hits	449	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BXL6, Q9BVB5	Gene names	CARD14, CARMA2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2).

HTRA1_HUMAN
NC score	0.073318 (rank : 200)	θ value	2.36792 (rank : 223)
Query Neighborhood Hits	298	Target Neighborhood Hits	155	Shared Neighborhood Hits	50
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

HTRA1_MOUSE
NC score	0.072359 (rank : 201)	θ value	2.36792 (rank : 224)
Query Neighborhood Hits	298	Target Neighborhood Hits	140	Shared Neighborhood Hits	50
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

PSMD9_HUMAN
NC score	0.071225 (rank : 202)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	298	Target Neighborhood Hits	36	Shared Neighborhood Hits	22
SwissProt Accessions	O00233, Q9BQ42	Gene names	PSMD9
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27).

MAST4_HUMAN
NC score	0.069079 (rank : 203)	θ value	0.00134147 (rank : 140)
Query Neighborhood Hits	298	Target Neighborhood Hits	1804	Shared Neighborhood Hits	153
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

LRRC1_MOUSE
NC score	0.068970 (rank : 204)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	298	Target Neighborhood Hits	281	Shared Neighborhood Hits	8
SwissProt Accessions	Q80VQ1, Q3UI50, Q8BKR1, Q8BUS9	Gene names	Lrrc1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 1.

LRRC1_HUMAN
NC score	0.068821 (rank : 205)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	298	Target Neighborhood Hits	282	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BTT6, Q9HAC0, Q9NVF1	Gene names	LRRC1, LANO
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 1 (LAP and no PDZ protein) (LANO adapter protein).

RGS3_HUMAN
NC score	0.068494 (rank : 206)	θ value	6.88961 (rank : 278)
Query Neighborhood Hits	298	Target Neighborhood Hits	1375	Shared Neighborhood Hits	97
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

MAST1_MOUSE
NC score	0.065839 (rank : 207)	θ value	0.00134147 (rank : 139)
Query Neighborhood Hits	298	Target Neighborhood Hits	1123	Shared Neighborhood Hits	129
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

RGS3_MOUSE
NC score	0.065696 (rank : 208)	θ value	6.88961 (rank : 279)
Query Neighborhood Hits	298	Target Neighborhood Hits	1621	Shared Neighborhood Hits	104
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

MAST3_HUMAN
NC score	0.064500 (rank : 209)	θ value	0.163984 (rank : 178)
Query Neighborhood Hits	298	Target Neighborhood Hits	1128	Shared Neighborhood Hits	128
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MAST1_HUMAN
NC score	0.064076 (rank : 210)	θ value	0.00228821 (rank : 148)
Query Neighborhood Hits	298	Target Neighborhood Hits	1146	Shared Neighborhood Hits	134
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST2_HUMAN
NC score	0.063105 (rank : 211)	θ value	0.21417 (rank : 180)
Query Neighborhood Hits	298	Target Neighborhood Hits	1189	Shared Neighborhood Hits	131
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

CAR14_MOUSE
NC score	0.061629 (rank : 212)	θ value	4.03905 (rank : 244)
Query Neighborhood Hits	298	Target Neighborhood Hits	526	Shared Neighborhood Hits	34
SwissProt Accessions	Q99KF0	Gene names	Card14, Bimp2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (Bcl10-interacting MAGUK protein 2) (Bimp2).

PEX10_HUMAN
NC score	0.061415 (rank : 213)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	298	Target Neighborhood Hits	255	Shared Neighborhood Hits	7
SwissProt Accessions	O60683, Q5T095, Q9BW90	Gene names	PEX10, RNF69
Domain Architecture
Description	Peroxisome assembly protein 10 (Peroxin-10) (Peroxisome biogenesis factor 10) (RING finger protein 69).

SAV1_HUMAN
NC score	0.061199 (rank : 214)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	298	Target Neighborhood Hits	51	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
NC score	0.061179 (rank : 215)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	298	Target Neighborhood Hits	48	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

MAST2_MOUSE
NC score	0.060717 (rank : 216)	θ value	0.47712 (rank : 191)
Query Neighborhood Hits	298	Target Neighborhood Hits	1110	Shared Neighborhood Hits	128
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

SI1L2_HUMAN
NC score	0.056702 (rank : 217)	θ value	4.03905 (rank : 250)
Query Neighborhood Hits	298	Target Neighborhood Hits	131	Shared Neighborhood Hits	47
SwissProt Accessions	Q9P2F8, Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6	Gene names	SIPA1L2, KIAA1389
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

TPPC4_MOUSE
NC score	0.056397 (rank : 218)	θ value	1.06291 (rank : 212)
Query Neighborhood Hits	298	Target Neighborhood Hits	11	Shared Neighborhood Hits	7
SwissProt Accessions	Q9ES56, Q9DB31	Gene names	Trappc4, Sbdn
Domain Architecture
Description	Trafficking protein particle complex subunit 4 (Synbindin) (TRS23 homolog).

CACB1_MOUSE
NC score	0.055356 (rank : 219)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	298	Target Neighborhood Hits	46	Shared Neighborhood Hits	21
SwissProt Accessions	Q8R3Z5, O88517, Q7TPF2, Q8R3Z6, Q9EPT9	Gene names	Cacnb1, Cacnlb1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1).

TPPC4_HUMAN
NC score	0.055288 (rank : 220)	θ value	1.06291 (rank : 211)
Query Neighborhood Hits	298	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y296	Gene names	TRAPPC4, SBDN
Domain Architecture
Description	Trafficking protein particle complex subunit 4 (Synbindin) (TRS23 homolog) (Hematopoietic stem/progenitor cell protein 172).

SI1L2_MOUSE
NC score	0.054780 (rank : 221)	θ value	4.03905 (rank : 251)
Query Neighborhood Hits	298	Target Neighborhood Hits	124	Shared Neighborhood Hits	47
SwissProt Accessions	Q80TE4, Q6PDY1	Gene names	Sipa1l2, Kiaa0545
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

WWC1_HUMAN
NC score	0.053963 (rank : 222)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	298	Target Neighborhood Hits	290	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

TRAF6_MOUSE
NC score	0.053241 (rank : 223)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	298	Target Neighborhood Hits	255	Shared Neighborhood Hits	7
SwissProt Accessions	P70196, Q8BLV2	Gene names	Traf6
Domain Architecture
Description	TNF receptor-associated factor 6.

CACB1_HUMAN
NC score	0.052979 (rank : 224)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	298	Target Neighborhood Hits	44	Shared Neighborhood Hits	22
SwissProt Accessions	Q02641, O15331, Q02639, Q02640, Q9C085	Gene names	CACNB1, CACNLB1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1).

CACB3_HUMAN
NC score	0.052804 (rank : 225)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	298	Target Neighborhood Hits	45	Shared Neighborhood Hits	17
SwissProt Accessions	P54284, Q13913	Gene names	CACNB3, CACNLB3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3).

CACB4_HUMAN
NC score	0.052781 (rank : 226)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	298	Target Neighborhood Hits	47	Shared Neighborhood Hits	19
SwissProt Accessions	O00305, O60515, Q96L40	Gene names	CACNB4, CACNLB4
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4).

CACB3_MOUSE
NC score	0.052763 (rank : 227)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	298	Target Neighborhood Hits	48	Shared Neighborhood Hits	18
SwissProt Accessions	P54285	Gene names	Cacnb3, Cacnlb3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3) (CCHB3).

WWC1_MOUSE
NC score	0.052094 (rank : 228)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	298	Target Neighborhood Hits	290	Shared Neighborhood Hits	11
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

RAIN_HUMAN
NC score	0.051798 (rank : 229)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	298	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	Q5U651, Q6U676	Gene names	RASIP1
Domain Architecture	No domain graphic available
Description	Ras-interacting protein 1 (Rain).

TRAF6_HUMAN
NC score	0.051727 (rank : 230)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	298	Target Neighborhood Hits	267	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y4K3, Q8NEH5	Gene names	TRAF6, RNF85
Domain Architecture
Description	TNF receptor-associated factor 6 (Interleukin 1 signal transducer) (RING finger protein 85).

FRMD1_HUMAN
NC score	0.051395 (rank : 231)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	298	Target Neighborhood Hits	48	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N878, Q5SZU7, Q9UFB0	Gene names	FRMD1
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 1.

YAP1_MOUSE
NC score	0.051199 (rank : 232)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	298	Target Neighborhood Hits	96	Shared Neighborhood Hits	10
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

HTRA4_HUMAN
NC score	0.051154 (rank : 233)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	298	Target Neighborhood Hits	119	Shared Neighborhood Hits	43
SwissProt Accessions	P83105, Q542Z4, Q6PF13	Gene names	HTRA4
Domain Architecture	No domain graphic available
Description	Probable serine protease HTRA4 precursor (EC 3.4.21.-).

CACB4_MOUSE
NC score	0.051102 (rank : 234)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	298	Target Neighborhood Hits	42	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R0S4, Q8BRN6, Q8CAJ9	Gene names	Cacnb4, Cacnlb4
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4).

RAIN_MOUSE
NC score	0.050804 (rank : 235)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	298	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q3U0S6, Q6GQW4	Gene names	Rasip1
Domain Architecture	No domain graphic available
Description	Ras-interacting protein 1 (Rain).

RAG1_HUMAN
NC score	0.050526 (rank : 236)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	298	Target Neighborhood Hits	203	Shared Neighborhood Hits	8
SwissProt Accessions	P15918, Q8NER2	Gene names	RAG1, RNF74
Domain Architecture
Description	V(D)J recombination-activating protein 1 (RAG-1) (RING finger protein 74).

SI1L1_HUMAN
NC score	0.050523 (rank : 237)	θ value	3.0926 (rank : 235)
Query Neighborhood Hits	298	Target Neighborhood Hits	162	Shared Neighborhood Hits	42
SwissProt Accessions	O43166, O95321, Q9UDU4, Q9UNU4	Gene names	SIPA1L1, E6TP1, KIAA0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1 (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6- targeted protein 1).

SI1L1_MOUSE
NC score	0.050130 (rank : 238)	θ value	3.0926 (rank : 236)
Query Neighborhood Hits	298	Target Neighborhood Hits	189	Shared Neighborhood Hits	44
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

SI1L3_HUMAN
NC score	0.043356 (rank : 239)	θ value	8.99809 (rank : 294)
Query Neighborhood Hits	298	Target Neighborhood Hits	305	Shared Neighborhood Hits	48
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

CDT1_HUMAN
NC score	0.039657 (rank : 240)	θ value	0.0431538 (rank : 168)
Query Neighborhood Hits	298	Target Neighborhood Hits	92	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H211, Q86XX9, Q96CJ5, Q96GK5, Q96H67, Q96HE6, Q9BWM0	Gene names	CDT1
Domain Architecture	No domain graphic available
Description	DNA replication factor Cdt1 (Double parked homolog) (DUP).

PCLO_HUMAN
NC score	0.036986 (rank : 241)	θ value	1.81305 (rank : 217)
Query Neighborhood Hits	298	Target Neighborhood Hits	2046	Shared Neighborhood Hits	80
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

LIMK2_MOUSE
NC score	0.036783 (rank : 242)	θ value	0.0736092 (rank : 171)
Query Neighborhood Hits	298	Target Neighborhood Hits	998	Shared Neighborhood Hits	73
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

SNUT1_HUMAN
NC score	0.034325 (rank : 243)	θ value	1.38821 (rank : 214)
Query Neighborhood Hits	298	Target Neighborhood Hits	129	Shared Neighborhood Hits	6
SwissProt Accessions	O43290, Q53GB5	Gene names	SART1
Domain Architecture	No domain graphic available
Description	U4/U6.U5 tri-snRNP-associated protein 1 (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (Squamous cell carcinoma antigen recognized by T cells 1) (SART-1) (hSART-1) (hSnu66).

LIMK2_HUMAN
NC score	0.033733 (rank : 244)	θ value	0.125558 (rank : 176)
Query Neighborhood Hits	298	Target Neighborhood Hits	986	Shared Neighborhood Hits	75
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK1_HUMAN
NC score	0.032936 (rank : 245)	θ value	0.813845 (rank : 200)
Query Neighborhood Hits	298	Target Neighborhood Hits	1005	Shared Neighborhood Hits	84
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

AFF1_HUMAN
NC score	0.032162 (rank : 246)	θ value	2.36792 (rank : 221)
Query Neighborhood Hits	298	Target Neighborhood Hits	506	Shared Neighborhood Hits	25
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

LIMK1_MOUSE
NC score	0.031710 (rank : 247)	θ value	0.813845 (rank : 201)
Query Neighborhood Hits	298	Target Neighborhood Hits	1008	Shared Neighborhood Hits	86
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

TAF7_MOUSE
NC score	0.031084 (rank : 248)	θ value	1.81305 (rank : 219)
Query Neighborhood Hits	298	Target Neighborhood Hits	217	Shared Neighborhood Hits	7
SwissProt Accessions	Q9R1C0	Gene names	Taf7, Taf2f
Domain Architecture
Description	Transcription initiation factor TFIID subunit 7 (Transcription initiation factor TFIID 55 kDa subunit) (TAF(II)55) (TAFII-55) (TAFII55).

AFF1_MOUSE
NC score	0.029533 (rank : 249)	θ value	0.365318 (rank : 186)
Query Neighborhood Hits	298	Target Neighborhood Hits	351	Shared Neighborhood Hits	16
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

SNUT1_MOUSE
NC score	0.028597 (rank : 250)	θ value	5.27518 (rank : 267)
Query Neighborhood Hits	298	Target Neighborhood Hits	159	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z315, Q8K155, Q9R1I9, Q9R270	Gene names	Sart1, Haf
Domain Architecture	No domain graphic available
Description	U4/U6.U5 tri-snRNP-associated protein 1 (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (mSART-1) (Hypoxia- associated factor).

D2HDH_HUMAN
NC score	0.027117 (rank : 251)	θ value	3.0926 (rank : 229)
Query Neighborhood Hits	298	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N465, Q6IQ24, Q8N5Q8	Gene names	D2HGDH, D2HGD
Domain Architecture	No domain graphic available
Description	D-2-hydroxyglutarate dehydrogenase, mitochondrial precursor (EC 1.1.99.-).

ATX2_HUMAN
NC score	0.025070 (rank : 252)	θ value	0.813845 (rank : 198)
Query Neighborhood Hits	298	Target Neighborhood Hits	375	Shared Neighborhood Hits	20
SwissProt Accessions	Q99700, Q6ZQZ7, Q99493	Gene names	ATXN2, ATX2, SCA2, TNRC13
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein).

CCDC4_HUMAN
NC score	0.024668 (rank : 253)	θ value	5.27518 (rank : 254)
Query Neighborhood Hits	298	Target Neighborhood Hits	104	Shared Neighborhood Hits	8
SwissProt Accessions	Q6ZU67, Q58A26, Q58A27	Gene names	CCDC4
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 4.

RP1L1_HUMAN
NC score	0.023003 (rank : 254)	θ value	2.36792 (rank : 226)
Query Neighborhood Hits	298	Target Neighborhood Hits	1072	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

TCOF_HUMAN
NC score	0.021660 (rank : 255)	θ value	8.99809 (rank : 295)
Query Neighborhood Hits	298	Target Neighborhood Hits	543	Shared Neighborhood Hits	21
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

RNF25_HUMAN
NC score	0.020922 (rank : 256)	θ value	1.06291 (rank : 209)
Query Neighborhood Hits	298	Target Neighborhood Hits	163	Shared Neighborhood Hits	11
SwissProt Accessions	Q96BH1, Q9H874	Gene names	RNF25
Domain Architecture
Description	RING finger protein 25 (EC 6.3.2.-).

K0310_HUMAN
NC score	0.020902 (rank : 257)	θ value	1.81305 (rank : 215)
Query Neighborhood Hits	298	Target Neighborhood Hits	420	Shared Neighborhood Hits	26
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

MUCDL_MOUSE
NC score	0.020258 (rank : 258)	θ value	0.47712 (rank : 192)
Query Neighborhood Hits	298	Target Neighborhood Hits	461	Shared Neighborhood Hits	30
SwissProt Accessions	Q8VHF2, Q8CEJ3, Q9D8I9	Gene names	Mucdhl
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

ATX2_MOUSE
NC score	0.020169 (rank : 259)	θ value	0.813845 (rank : 199)
Query Neighborhood Hits	298	Target Neighborhood Hits	445	Shared Neighborhood Hits	20
SwissProt Accessions	O70305, P97421	Gene names	Atxn2, Atx2, Sca2
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein homolog).

DJC17_MOUSE
NC score	0.018435 (rank : 260)	θ value	0.279714 (rank : 182)
Query Neighborhood Hits	298	Target Neighborhood Hits	217	Shared Neighborhood Hits	6
SwissProt Accessions	Q91WT4, Q8C5R1	Gene names	Dnajc17
Domain Architecture	No domain graphic available
Description	DnaJ homolog subfamily C member 17.

PRG4_HUMAN
NC score	0.017940 (rank : 261)	θ value	6.88961 (rank : 277)
Query Neighborhood Hits	298	Target Neighborhood Hits	764	Shared Neighborhood Hits	34
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

K0082_MOUSE
NC score	0.016974 (rank : 262)	θ value	5.27518 (rank : 258)
Query Neighborhood Hits	298	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q9DBC3, Q3U3G5, Q3U7Y9, Q6A0D5, Q8C7V0	Gene names	Kiaa0082
Domain Architecture	No domain graphic available
Description	Protein KIAA0082.

DPOLZ_MOUSE
NC score	0.016312 (rank : 263)	θ value	1.06291 (rank : 206)
Query Neighborhood Hits	298	Target Neighborhood Hits	169	Shared Neighborhood Hits	14
SwissProt Accessions	Q61493, Q9JMD6, Q9QWX6	Gene names	Rev3l, Polz, Sez4
Domain Architecture
Description	DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Seizure-related protein 4).

PO121_MOUSE
NC score	0.016143 (rank : 264)	θ value	1.06291 (rank : 208)
Query Neighborhood Hits	298	Target Neighborhood Hits	345	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K3Z9, Q7TSH5	Gene names	Pom121, Nup121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa).

TENS1_HUMAN
NC score	0.016061 (rank : 265)	θ value	1.06291 (rank : 210)
Query Neighborhood Hits	298	Target Neighborhood Hits	400	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

DJC17_HUMAN
NC score	0.015959 (rank : 266)	θ value	1.06291 (rank : 205)
Query Neighborhood Hits	298	Target Neighborhood Hits	335	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NVM6	Gene names	DNAJC17
Domain Architecture	No domain graphic available
Description	DnaJ homolog subfamily C member 17.

PDYN_HUMAN
NC score	0.015547 (rank : 267)	θ value	2.36792 (rank : 225)
Query Neighborhood Hits	298	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	P01213	Gene names	PDYN
Domain Architecture
Description	Beta-neoendorphin-dynorphin precursor (Proenkephalin B) (Preprodynorphin) [Contains: Beta-neoendorphin; Dynorphin; Leu- enkephalin; Rimorphin; Leumorphin].

TAF3_MOUSE
NC score	0.015376 (rank : 268)	θ value	3.0926 (rank : 238)
Query Neighborhood Hits	298	Target Neighborhood Hits	463	Shared Neighborhood Hits	17
SwissProt Accessions	Q5HZG4, Q3U490, Q3UWX2, Q8BIU8, Q99JH4	Gene names	Taf3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

PININ_HUMAN
NC score	0.014167 (rank : 269)	θ value	5.27518 (rank : 261)
Query Neighborhood Hits	298	Target Neighborhood Hits	753	Shared Neighborhood Hits	25
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

CD68_HUMAN
NC score	0.014012 (rank : 270)	θ value	2.36792 (rank : 222)
Query Neighborhood Hits	298	Target Neighborhood Hits	67	Shared Neighborhood Hits	4
SwissProt Accessions	P34810, Q96BI7	Gene names	CD68
Domain Architecture
Description	Macrosialin precursor (GP110) (CD68 antigen).

UN13A_HUMAN
NC score	0.013984 (rank : 271)	θ value	2.36792 (rank : 228)
Query Neighborhood Hits	298	Target Neighborhood Hits	285	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

ANTOL_HUMAN
NC score	0.013507 (rank : 272)	θ value	4.03905 (rank : 241)
Query Neighborhood Hits	298	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q96GY3, O14557, Q7Z2T9	Gene names	ames=MSTP064
Domain Architecture	No domain graphic available
Description	Antolefinin.

ELK4_MOUSE
NC score	0.013042 (rank : 273)	θ value	0.163984 (rank : 177)
Query Neighborhood Hits	298	Target Neighborhood Hits	107	Shared Neighborhood Hits	5
SwissProt Accessions	P41158	Gene names	Elk4, Sap1
Domain Architecture
Description	ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1).

TAF3_HUMAN
NC score	0.012710 (rank : 274)	θ value	5.27518 (rank : 268)
Query Neighborhood Hits	298	Target Neighborhood Hits	568	Shared Neighborhood Hits	17
SwissProt Accessions	Q5VWG9, Q6GMS5, Q6P6B5, Q86VY6, Q9BQS9, Q9UFI8	Gene names	TAF3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

UBP42_HUMAN
NC score	0.012644 (rank : 275)	θ value	1.81305 (rank : 220)
Query Neighborhood Hits	298	Target Neighborhood Hits	445	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

ZC3H3_MOUSE
NC score	0.012474 (rank : 276)	θ value	8.99809 (rank : 298)
Query Neighborhood Hits	298	Target Neighborhood Hits	188	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CHP0, Q80X78	Gene names	Zc3h3, Kiaa0150, Zc3hdc3, Zfp623
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 3.

PELP1_MOUSE
NC score	0.012262 (rank : 277)	θ value	3.0926 (rank : 233)
Query Neighborhood Hits	298	Target Neighborhood Hits	709	Shared Neighborhood Hits	23
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

PUR1_HUMAN
NC score	0.012097 (rank : 278)	θ value	5.27518 (rank : 266)
Query Neighborhood Hits	298	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q06203	Gene names	PPAT, GPAT
Domain Architecture
Description	Amidophosphoribosyltransferase precursor (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (GPAT).

LRC56_HUMAN
NC score	0.010935 (rank : 279)	θ value	6.88961 (rank : 276)
Query Neighborhood Hits	298	Target Neighborhood Hits	165	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IYG6, Q8N3Q4	Gene names	LRRC56
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 56.

IF35_MOUSE
NC score	0.010518 (rank : 280)	θ value	6.88961 (rank : 275)
Query Neighborhood Hits	298	Target Neighborhood Hits	210	Shared Neighborhood Hits	16
SwissProt Accessions	Q9DCH4	Gene names	Eif3s5
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 5 (eIF-3 epsilon) (eIF3 p47 subunit) (eIF3f).

PI51A_HUMAN
NC score	0.010255 (rank : 281)	θ value	0.813845 (rank : 203)
Query Neighborhood Hits	298	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q99755, Q99754, Q99756	Gene names	PIP5K1A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I alpha) (PtdIns(4)P- 5-kinase alpha) (PIP5KIalpha) (68 kDa type I phosphatidylinositol-4- phosphate 5-kinase alpha).

MBD4_HUMAN
NC score	0.010183 (rank : 282)	θ value	4.03905 (rank : 246)
Query Neighborhood Hits	298	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	O95243, Q7Z4T3, Q96F09	Gene names	MBD4, MED1
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 4 (EC 3.2.2.-) (Methyl-CpG-binding protein MBD4) (Methyl-CpG-binding endonuclease 1) (Mismatch-specific DNA N-glycosylase).

K1688_MOUSE
NC score	0.010164 (rank : 283)	θ value	5.27518 (rank : 259)
Query Neighborhood Hits	298	Target Neighborhood Hits	188	Shared Neighborhood Hits	11
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

APOA4_MOUSE
NC score	0.010078 (rank : 284)	θ value	0.813845 (rank : 197)
Query Neighborhood Hits	298	Target Neighborhood Hits	435	Shared Neighborhood Hits	10
SwissProt Accessions	P06728	Gene names	Apoa4
Domain Architecture
Description	Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV).

PER3_MOUSE
NC score	0.010002 (rank : 285)	θ value	1.06291 (rank : 207)
Query Neighborhood Hits	298	Target Neighborhood Hits	85	Shared Neighborhood Hits	3
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

HSN2_MOUSE
NC score	0.009979 (rank : 286)	θ value	5.27518 (rank : 257)
Query Neighborhood Hits	298	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q6IFS6	Gene names	Hsn2
Domain Architecture	No domain graphic available
Description	Protein HSN2 precursor.

UBP2L_MOUSE
NC score	0.009733 (rank : 287)	θ value	6.88961 (rank : 280)
Query Neighborhood Hits	298	Target Neighborhood Hits	173	Shared Neighborhood Hits	12
SwissProt Accessions	Q80X50, Q8BIT6, Q8BIW4, Q8BJ01, Q8CIG7, Q8K102, Q9CRT6	Gene names	Ubap2l
Domain Architecture	No domain graphic available
Description	Ubiquitin-associated protein 2-like.

PKD2_MOUSE
NC score	0.009356 (rank : 288)	θ value	1.81305 (rank : 218)
Query Neighborhood Hits	298	Target Neighborhood Hits	99	Shared Neighborhood Hits	6
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

NPHP3_MOUSE
NC score	0.009136 (rank : 289)	θ value	3.0926 (rank : 231)
Query Neighborhood Hits	298	Target Neighborhood Hits	335	Shared Neighborhood Hits	9
SwissProt Accessions	Q7TNH6, Q69Z39, Q8C798, Q8C7Z3, Q9D6D1	Gene names	Nphp3, Kiaa2000
Domain Architecture	No domain graphic available
Description	Nephrocystin-3.

CJ006_HUMAN
NC score	0.008710 (rank : 290)	θ value	5.27518 (rank : 255)
Query Neighborhood Hits	298	Target Neighborhood Hits	122	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IX21, Q5W0L8, Q9NPE8	Gene names	C10orf6
Domain Architecture	No domain graphic available
Description	Protein C10orf6.

PF21B_MOUSE
NC score	0.008316 (rank : 291)	θ value	3.0926 (rank : 234)
Query Neighborhood Hits	298	Target Neighborhood Hits	278	Shared Neighborhood Hits	19
SwissProt Accessions	Q8C966	Gene names	Phf21b
Domain Architecture	No domain graphic available
Description	PHD finger protein 21B.

PLCD1_MOUSE
NC score	0.007617 (rank : 292)	θ value	5.27518 (rank : 263)
Query Neighborhood Hits	298	Target Neighborhood Hits	106	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

FA54A_MOUSE
NC score	0.007568 (rank : 293)	θ value	8.99809 (rank : 288)
Query Neighborhood Hits	298	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VED8	Gene names	Fam54a, Dufd1
Domain Architecture	No domain graphic available
Description	Protein FAM54A (DUF729 domain-containing protein 1).

WASF1_MOUSE
NC score	0.007223 (rank : 294)	θ value	6.88961 (rank : 282)
Query Neighborhood Hits	298	Target Neighborhood Hits	261	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R5H6, Q91W51, Q9ERQ9	Gene names	Wasf1, Wave1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1).

WASF1_HUMAN
NC score	0.007193 (rank : 295)	θ value	6.88961 (rank : 281)
Query Neighborhood Hits	298	Target Neighborhood Hits	260	Shared Neighborhood Hits	12
SwissProt Accessions	Q92558	Gene names	WASF1, KIAA0269, SCAR1, WAVE1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1).

MYH10_MOUSE
NC score	0.007023 (rank : 296)	θ value	8.99809 (rank : 290)
Query Neighborhood Hits	298	Target Neighborhood Hits	1612	Shared Neighborhood Hits	36
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

SPTN5_HUMAN
NC score	0.006579 (rank : 297)	θ value	4.03905 (rank : 252)
Query Neighborhood Hits	298	Target Neighborhood Hits	674	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

BCLX_MOUSE
NC score	0.006531 (rank : 298)	θ value	6.88961 (rank : 269)
Query Neighborhood Hits	298	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	Q64373, O35844, Q60657, Q60658, Q61338	Gene names	Bcl2l1, Bcl2l, Bclx
Domain Architecture
Description	Apoptosis regulator Bcl-X (Bcl-2-like 1 protein).

CN092_MOUSE
NC score	0.006268 (rank : 299)	θ value	5.27518 (rank : 256)
Query Neighborhood Hits	298	Target Neighborhood Hits	206	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BU11, Q80UI2, Q99PN9, Q9CS16	Gene names
Domain Architecture
Description	Epidermal Langerhans cell protein LCP1.

TS101_MOUSE
NC score	0.005796 (rank : 300)	θ value	8.99809 (rank : 297)
Query Neighborhood Hits	298	Target Neighborhood Hits	312	Shared Neighborhood Hits	11
SwissProt Accessions	Q61187	Gene names	Tsg101
Domain Architecture
Description	Tumor susceptibility gene 101 protein.

BCLX_HUMAN
NC score	0.005773 (rank : 301)	θ value	8.99809 (rank : 285)
Query Neighborhood Hits	298	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q07817, Q5TE65, Q92976	Gene names	BCL2L1, BCL2L, BCLX
Domain Architecture
Description	Apoptosis regulator Bcl-X (Bcl-2-like 1 protein).

CAMKV_HUMAN
NC score	0.005651 (rank : 302)	θ value	4.03905 (rank : 242)
Query Neighborhood Hits	298	Target Neighborhood Hits	1084	Shared Neighborhood Hits	39
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

DPOLL_HUMAN
NC score	0.005153 (rank : 303)	θ value	6.88961 (rank : 274)
Query Neighborhood Hits	298	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UGP5, Q5JQP5, Q6NUM2, Q9HA10, Q9HB35	Gene names	POLL
Domain Architecture
Description	DNA polymerase lambda (EC 2.7.7.7) (EC 4.2.99.-) (Pol Lambda) (DNA polymerase kappa) (DNA polymerase beta-2) (Pol beta2).

DNJC1_HUMAN
NC score	0.005071 (rank : 304)	θ value	6.88961 (rank : 273)
Query Neighborhood Hits	298	Target Neighborhood Hits	127	Shared Neighborhood Hits	6
SwissProt Accessions	Q96KC8	Gene names	DNAJC1
Domain Architecture
Description	DnaJ homolog subfamily C member 1.

CHSS2_MOUSE
NC score	0.004923 (rank : 305)	θ value	6.88961 (rank : 270)
Query Neighborhood Hits	298	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q6IQX7	Gene names	Css2, D1Bwg1363e
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate synthase 2 (EC 2.4.1.175) (Glucuronosyl-N- acetylgalactosaminyl-proteoglycan 4-beta-N- acetylgalactosaminyltransferase II) (N-acetylgalactosaminyl- proteoglycan 3-beta-glucuronosyltransferase II) (EC 2.4.1.226) (Chondroitin glucuronyltransferase II) (N- acetylgalactosaminyltransferase).

MUC2_HUMAN
NC score	0.004767 (rank : 306)	θ value	5.27518 (rank : 260)
Query Neighborhood Hits	298	Target Neighborhood Hits	906	Shared Neighborhood Hits	31
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

EPC2_HUMAN
NC score	0.004457 (rank : 307)	θ value	8.99809 (rank : 287)
Query Neighborhood Hits	298	Target Neighborhood Hits	58	Shared Neighborhood Hits	3
SwissProt Accessions	Q52LR7, Q7L9J1, Q96RR7, Q9NUT8, Q9NVR1, Q9UFM9	Gene names	EPC2
Domain Architecture	No domain graphic available
Description	Enhancer of polycomb homolog 2.

CAMKV_MOUSE
NC score	0.004423 (rank : 308)	θ value	4.03905 (rank : 243)
Query Neighborhood Hits	298	Target Neighborhood Hits	848	Shared Neighborhood Hits	24
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

MAPK5_MOUSE
NC score	0.004327 (rank : 309)	θ value	1.81305 (rank : 216)
Query Neighborhood Hits	298	Target Neighborhood Hits	799	Shared Neighborhood Hits	18
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

GATA5_MOUSE
NC score	0.004167 (rank : 310)	θ value	8.99809 (rank : 289)
Query Neighborhood Hits	298	Target Neighborhood Hits	51	Shared Neighborhood Hits	6
SwissProt Accessions	P97489	Gene names	Gata5
Domain Architecture
Description	Transcription factor GATA-5 (GATA-binding factor 5).

RGMC_MOUSE
NC score	0.003946 (rank : 311)	θ value	8.99809 (rank : 293)
Query Neighborhood Hits	298	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q7TQ32, Q8CEU7, Q8K1D4, Q9D741	Gene names	Hfe2, Rgmc
Domain Architecture	No domain graphic available
Description	Hemojuvelin precursor (Hemochromatosis type 2 protein homolog) (RGM domain family member C).

LRBA_HUMAN
NC score	0.003625 (rank : 312)	θ value	4.03905 (rank : 245)
Query Neighborhood Hits	298	Target Neighborhood Hits	196	Shared Neighborhood Hits	4
SwissProt Accessions	P50851, Q9H2U3, Q9H2U4	Gene names	LRBA, BGL, CDC4L, LBA
Domain Architecture
Description	Lipopolysaccharide-responsive and beige-like anchor protein (CDC4-like protein) (Beige-like protein).

CLC4K_MOUSE
NC score	0.002704 (rank : 313)	θ value	8.99809 (rank : 286)
Query Neighborhood Hits	298	Target Neighborhood Hits	165	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VBX4, Q8R442	Gene names	Cd207, Clec4k
Domain Architecture	No domain graphic available
Description	C-type lectin domain family 4 member K (Langerin) (CD207 antigen).

NRX1A_HUMAN
NC score	0.002438 (rank : 314)	θ value	3.0926 (rank : 232)
Query Neighborhood Hits	298	Target Neighborhood Hits	170	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ULB1, O60323, Q53TJ9, Q53TQ1, Q9C079, Q9C080, Q9C081, Q9H3M2, Q9UDM6	Gene names	NRXN1, KIAA0578
Domain Architecture
Description	Neurexin-1-alpha precursor (Neurexin I-alpha).

WDR22_MOUSE
NC score	0.002203 (rank : 315)	θ value	3.0926 (rank : 239)
Query Neighborhood Hits	298	Target Neighborhood Hits	302	Shared Neighborhood Hits	2
SwissProt Accessions	Q80T85, Q80VT3, Q80ZW6, Q8BIP8, Q8BVK5, Q8K0Q6	Gene names	Wdr22, Kiaa1824
Domain Architecture
Description	WD repeat protein 22.

TNR1B_MOUSE
NC score	0.001985 (rank : 316)	θ value	8.99809 (rank : 296)
Query Neighborhood Hits	298	Target Neighborhood Hits	123	Shared Neighborhood Hits	4
SwissProt Accessions	P25119, O88734, P97893	Gene names	Tnfrsf1b, Tnfr-2, Tnfr2
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1B precursor (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (p75) (p80 TNF-alpha receptor).

RAI14_MOUSE
NC score	0.001978 (rank : 317)	θ value	4.03905 (rank : 249)
Query Neighborhood Hits	298	Target Neighborhood Hits	1505	Shared Neighborhood Hits	35
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

DDFL1_MOUSE
NC score	0.001822 (rank : 318)	θ value	3.0926 (rank : 230)
Query Neighborhood Hits	298	Target Neighborhood Hits	324	Shared Neighborhood Hits	5
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

PKD1_HUMAN
NC score	0.001609 (rank : 319)	θ value	5.27518 (rank : 262)
Query Neighborhood Hits	298	Target Neighborhood Hits	387	Shared Neighborhood Hits	6
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

CSPG2_MOUSE
NC score	0.001484 (rank : 320)	θ value	6.88961 (rank : 272)
Query Neighborhood Hits	298	Target Neighborhood Hits	711	Shared Neighborhood Hits	22
SwissProt Accessions	Q62059, Q62058, Q9CUU0	Gene names	Cspg2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M).

PO2F1_MOUSE
NC score	0.001312 (rank : 321)	θ value	5.27518 (rank : 265)
Query Neighborhood Hits	298	Target Neighborhood Hits	408	Shared Neighborhood Hits	6
SwissProt Accessions	P25425, Q61994, Q63891, Q6Y681, Q7TSD0, Q8BT04, Q8K570, Q99JH0, Q9WTZ4, Q9WTZ5, Q9WTZ6	Gene names	Pou2f1, Oct-1, Otf-1, Otf1
Domain Architecture
Description	POU domain, class 2, transcription factor 1 (Octamer-binding transcription factor 1) (Oct-1) (OTF-1) (NF-A1).

PPE2_MOUSE
NC score	0.001235 (rank : 322)	θ value	8.99809 (rank : 292)
Query Neighborhood Hits	298	Target Neighborhood Hits	112	Shared Neighborhood Hits	2
SwissProt Accessions	O35385	Gene names	Ppef2
Domain Architecture
Description	Serine/threonine-protein phosphatase with EF-hands 2 (EC 3.1.3.16) (PPEF-2).

CPXM2_MOUSE
NC score	0.001053 (rank : 323)	θ value	6.88961 (rank : 271)
Query Neighborhood Hits	298	Target Neighborhood Hits	58	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D2L5, O54860, Q8VDQ4	Gene names	Cpxm2, Cpx2
Domain Architecture
Description	Carboxypeptidase-like protein X2 precursor.

PO2F1_HUMAN
NC score	0.000946 (rank : 324)	θ value	5.27518 (rank : 264)
Query Neighborhood Hits	298	Target Neighborhood Hits	426	Shared Neighborhood Hits	8
SwissProt Accessions	P14859, Q5TBT7, Q6PK46, Q8NEU9, Q9BPV1	Gene names	POU2F1, OCT1, OTF1
Domain Architecture
Description	POU domain, class 2, transcription factor 1 (Octamer-binding transcription factor 1) (Oct-1) (OTF-1) (NF-A1).

ATP9A_MOUSE
NC score	0.000040 (rank : 325)	θ value	8.99809 (rank : 284)
Query Neighborhood Hits	298	Target Neighborhood Hits	61	Shared Neighborhood Hits	2
SwissProt Accessions	O70228, Q8VDI5, Q922L9	Gene names	Atp9a
Domain Architecture	No domain graphic available
Description	Probable phospholipid-transporting ATPase IIA (EC 3.6.3.1) (ATPase class II type 9A).

PCDG6_HUMAN
NC score	-0.002397 (rank : 326)	θ value	4.03905 (rank : 247)
Query Neighborhood Hits	298	Target Neighborhood Hits	156	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y5G7, Q9Y5D1	Gene names	PCDHGA6
Domain Architecture
Description	Protocadherin gamma A6 precursor (PCDH-gamma-A6).

ABL1_HUMAN
NC score	-0.002523 (rank : 327)	θ value	5.27518 (rank : 253)
Query Neighborhood Hits	298	Target Neighborhood Hits	1220	Shared Neighborhood Hits	31
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

SALL3_HUMAN
NC score	-0.005411 (rank : 328)	θ value	2.36792 (rank : 227)
Query Neighborhood Hits	298	Target Neighborhood Hits	1066	Shared Neighborhood Hits	22
SwissProt Accessions	Q9BXA9, Q9UGH1	Gene names	SALL3
Domain Architecture	No domain graphic available
Description	Sal-like protein 3 (Zinc finger protein SALL3) (hSALL3).

ZN358_HUMAN
NC score	-0.008847 (rank : 329)	θ value	3.0926 (rank : 240)
Query Neighborhood Hits	298	Target Neighborhood Hits	840	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NW07, Q9BTM7	Gene names	ZNF358
Domain Architecture
Description	Zinc finger protein 358.

ZBT17_HUMAN
NC score	-0.010098 (rank : 330)	θ value	6.88961 (rank : 283)
Query Neighborhood Hits	298	Target Neighborhood Hits	925	Shared Neighborhood Hits	5
SwissProt Accessions	Q13105, Q15932, Q5JYB2, Q9NUC9	Gene names	ZBTB17, MIZ1, ZNF151
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 17 (Zinc finger protein 151) (Myc-interacting zinc finger protein) (Miz-1 protein).