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Network neighborhood for query Sequence : PAR3L_HUMAN

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PAR3L_HUMAN
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PAR3L_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	297	Target Neighborhood Hits	297	Shared Neighborhood Hits	297
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

PARD3_MOUSE
θ value	5.41814e-138 (rank : 2)	NC score	0.936136 (rank : 2)
Query Neighborhood Hits	297	Target Neighborhood Hits	290	Shared Neighborhood Hits	154
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

PARD3_HUMAN
θ value	1.93603e-119 (rank : 3)	NC score	0.932436 (rank : 3)
Query Neighborhood Hits	297	Target Neighborhood Hits	312	Shared Neighborhood Hits	157
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

MPDZ_HUMAN
θ value	4.43474e-23 (rank : 4)	NC score	0.806879 (rank : 4)
Query Neighborhood Hits	297	Target Neighborhood Hits	261	Shared Neighborhood Hits	156
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

INADL_HUMAN
θ value	1.09232e-21 (rank : 5)	NC score	0.804964 (rank : 5)
Query Neighborhood Hits	297	Target Neighborhood Hits	260	Shared Neighborhood Hits	156
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

INADL_MOUSE
θ value	3.17815e-21 (rank : 6)	NC score	0.802289 (rank : 7)
Query Neighborhood Hits	297	Target Neighborhood Hits	290	Shared Neighborhood Hits	157
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

MPDZ_MOUSE
θ value	5.42112e-21 (rank : 7)	NC score	0.804569 (rank : 6)
Query Neighborhood Hits	297	Target Neighborhood Hits	298	Shared Neighborhood Hits	157
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

DLG1_HUMAN
θ value	6.85773e-16 (rank : 8)	NC score	0.704440 (rank : 26)
Query Neighborhood Hits	297	Target Neighborhood Hits	290	Shared Neighborhood Hits	155
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

DLG3_MOUSE
θ value	6.85773e-16 (rank : 9)	NC score	0.706130 (rank : 21)
Query Neighborhood Hits	297	Target Neighborhood Hits	274	Shared Neighborhood Hits	155
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

LNX2_MOUSE
θ value	6.85773e-16 (rank : 10)	NC score	0.727321 (rank : 9)
Query Neighborhood Hits	297	Target Neighborhood Hits	407	Shared Neighborhood Hits	150
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

PTN13_HUMAN
θ value	6.85773e-16 (rank : 11)	NC score	0.460682 (rank : 93)
Query Neighborhood Hits	297	Target Neighborhood Hits	471	Shared Neighborhood Hits	165
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

DLG4_MOUSE
θ value	8.95645e-16 (rank : 12)	NC score	0.716283 (rank : 12)
Query Neighborhood Hits	297	Target Neighborhood Hits	282	Shared Neighborhood Hits	153
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG3_HUMAN
θ value	1.16975e-15 (rank : 13)	NC score	0.702286 (rank : 27)
Query Neighborhood Hits	297	Target Neighborhood Hits	269	Shared Neighborhood Hits	155
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

LNX2_HUMAN
θ value	1.16975e-15 (rank : 14)	NC score	0.721116 (rank : 10)
Query Neighborhood Hits	297	Target Neighborhood Hits	389	Shared Neighborhood Hits	148
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

DLG1_MOUSE
θ value	1.52774e-15 (rank : 15)	NC score	0.704957 (rank : 23)
Query Neighborhood Hits	297	Target Neighborhood Hits	285	Shared Neighborhood Hits	153
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

DLG4_HUMAN
θ value	1.52774e-15 (rank : 16)	NC score	0.715296 (rank : 13)
Query Neighborhood Hits	297	Target Neighborhood Hits	286	Shared Neighborhood Hits	153
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

LAP4_HUMAN
θ value	2.60593e-15 (rank : 17)	NC score	0.488508 (rank : 88)
Query Neighborhood Hits	297	Target Neighborhood Hits	608	Shared Neighborhood Hits	159
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

LNX1_HUMAN
θ value	7.58209e-15 (rank : 18)	NC score	0.711871 (rank : 15)
Query Neighborhood Hits	297	Target Neighborhood Hits	379	Shared Neighborhood Hits	138
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

LNX1_MOUSE
θ value	9.90251e-15 (rank : 19)	NC score	0.716359 (rank : 11)
Query Neighborhood Hits	297	Target Neighborhood Hits	377	Shared Neighborhood Hits	149
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

DLG2_MOUSE
θ value	1.68911e-14 (rank : 20)	NC score	0.699762 (rank : 28)
Query Neighborhood Hits	297	Target Neighborhood Hits	271	Shared Neighborhood Hits	153
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG2_HUMAN
θ value	3.76295e-14 (rank : 21)	NC score	0.698477 (rank : 29)
Query Neighborhood Hits	297	Target Neighborhood Hits	279	Shared Neighborhood Hits	154
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

LAP4_MOUSE
θ value	4.91457e-14 (rank : 22)	NC score	0.486387 (rank : 89)
Query Neighborhood Hits	297	Target Neighborhood Hits	590	Shared Neighborhood Hits	157
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

PTN13_MOUSE
θ value	1.86753e-13 (rank : 23)	NC score	0.447929 (rank : 95)
Query Neighborhood Hits	297	Target Neighborhood Hits	426	Shared Neighborhood Hits	159
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

PDZD2_HUMAN
θ value	5.43371e-13 (rank : 24)	NC score	0.705475 (rank : 22)
Query Neighborhood Hits	297	Target Neighborhood Hits	772	Shared Neighborhood Hits	176
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

IL16_HUMAN
θ value	2.69671e-12 (rank : 25)	NC score	0.712715 (rank : 14)
Query Neighborhood Hits	297	Target Neighborhood Hits	207	Shared Neighborhood Hits	132
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

MAGI1_MOUSE
θ value	3.89403e-11 (rank : 26)	NC score	0.653529 (rank : 39)
Query Neighborhood Hits	297	Target Neighborhood Hits	403	Shared Neighborhood Hits	164
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MAGI2_MOUSE
θ value	1.133e-10 (rank : 27)	NC score	0.631560 (rank : 42)
Query Neighborhood Hits	297	Target Neighborhood Hits	370	Shared Neighborhood Hits	166
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

MAGI2_HUMAN
θ value	1.9326e-10 (rank : 28)	NC score	0.628727 (rank : 43)
Query Neighborhood Hits	297	Target Neighborhood Hits	373	Shared Neighborhood Hits	160
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

PDZD1_HUMAN
θ value	3.29651e-10 (rank : 29)	NC score	0.647620 (rank : 40)
Query Neighborhood Hits	297	Target Neighborhood Hits	190	Shared Neighborhood Hits	125
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

IL16_MOUSE
θ value	2.79066e-09 (rank : 30)	NC score	0.680712 (rank : 31)
Query Neighborhood Hits	297	Target Neighborhood Hits	189	Shared Neighborhood Hits	131
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

PDZD1_MOUSE
θ value	2.79066e-09 (rank : 31)	NC score	0.653715 (rank : 38)
Query Neighborhood Hits	297	Target Neighborhood Hits	191	Shared Neighborhood Hits	127
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

NEB2_HUMAN
θ value	4.76016e-09 (rank : 32)	NC score	0.483935 (rank : 90)
Query Neighborhood Hits	297	Target Neighborhood Hits	883	Shared Neighborhood Hits	157
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEB2_MOUSE
θ value	4.76016e-09 (rank : 33)	NC score	0.478872 (rank : 91)
Query Neighborhood Hits	297	Target Neighborhood Hits	889	Shared Neighborhood Hits	161
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

SYJ2B_HUMAN
θ value	6.21693e-09 (rank : 34)	NC score	0.775886 (rank : 8)
Query Neighborhood Hits	297	Target Neighborhood Hits	162	Shared Neighborhood Hits	134
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

NEB1_HUMAN
θ value	8.11959e-09 (rank : 35)	NC score	0.503176 (rank : 82)
Query Neighborhood Hits	297	Target Neighborhood Hits	829	Shared Neighborhood Hits	163
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

PZRN3_MOUSE
θ value	1.06045e-08 (rank : 36)	NC score	0.590329 (rank : 49)
Query Neighborhood Hits	297	Target Neighborhood Hits	447	Shared Neighborhood Hits	139
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

WHRN_HUMAN
θ value	1.80886e-08 (rank : 37)	NC score	0.670370 (rank : 33)
Query Neighborhood Hits	297	Target Neighborhood Hits	325	Shared Neighborhood Hits	157
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

WHRN_MOUSE
θ value	1.80886e-08 (rank : 38)	NC score	0.666972 (rank : 34)
Query Neighborhood Hits	297	Target Neighborhood Hits	412	Shared Neighborhood Hits	159
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

MAGI1_HUMAN
θ value	2.36244e-08 (rank : 39)	NC score	0.643939 (rank : 41)
Query Neighborhood Hits	297	Target Neighborhood Hits	388	Shared Neighborhood Hits	161
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

USH1C_HUMAN
θ value	2.36244e-08 (rank : 40)	NC score	0.706682 (rank : 18)
Query Neighborhood Hits	297	Target Neighborhood Hits	327	Shared Neighborhood Hits	164
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

NHRF2_HUMAN
θ value	5.26297e-08 (rank : 41)	NC score	0.620461 (rank : 45)
Query Neighborhood Hits	297	Target Neighborhood Hits	197	Shared Neighborhood Hits	134
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

PZRN3_HUMAN
θ value	5.26297e-08 (rank : 42)	NC score	0.586049 (rank : 51)
Query Neighborhood Hits	297	Target Neighborhood Hits	461	Shared Neighborhood Hits	145
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PDZD7_HUMAN
θ value	6.87365e-08 (rank : 43)	NC score	0.697463 (rank : 30)
Query Neighborhood Hits	297	Target Neighborhood Hits	181	Shared Neighborhood Hits	138
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

PZRN4_HUMAN
θ value	6.87365e-08 (rank : 44)	NC score	0.589780 (rank : 50)
Query Neighborhood Hits	297	Target Neighborhood Hits	438	Shared Neighborhood Hits	141
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

AFAD_HUMAN
θ value	1.17247e-07 (rank : 45)	NC score	0.524657 (rank : 70)
Query Neighborhood Hits	297	Target Neighborhood Hits	689	Shared Neighborhood Hits	167
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

NHERF_MOUSE
θ value	1.53129e-07 (rank : 46)	NC score	0.624403 (rank : 44)
Query Neighborhood Hits	297	Target Neighborhood Hits	195	Shared Neighborhood Hits	127
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

USH1C_MOUSE
θ value	1.99992e-07 (rank : 47)	NC score	0.660826 (rank : 37)
Query Neighborhood Hits	297	Target Neighborhood Hits	557	Shared Neighborhood Hits	182
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

GRIP1_HUMAN
θ value	2.61198e-07 (rank : 48)	NC score	0.666634 (rank : 35)
Query Neighborhood Hits	297	Target Neighborhood Hits	231	Shared Neighborhood Hits	154
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

GRIP1_MOUSE
θ value	2.61198e-07 (rank : 49)	NC score	0.663730 (rank : 36)
Query Neighborhood Hits	297	Target Neighborhood Hits	241	Shared Neighborhood Hits	154
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

DVL1_MOUSE
θ value	3.41135e-07 (rank : 50)	NC score	0.511561 (rank : 75)
Query Neighborhood Hits	297	Target Neighborhood Hits	146	Shared Neighborhood Hits	118
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

GRIP2_HUMAN
θ value	5.81887e-07 (rank : 51)	NC score	0.675863 (rank : 32)
Query Neighborhood Hits	297	Target Neighborhood Hits	256	Shared Neighborhood Hits	155
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

LIN7A_HUMAN
θ value	5.81887e-07 (rank : 52)	NC score	0.704752 (rank : 25)
Query Neighborhood Hits	297	Target Neighborhood Hits	193	Shared Neighborhood Hits	150
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7A_MOUSE
θ value	5.81887e-07 (rank : 53)	NC score	0.704893 (rank : 24)
Query Neighborhood Hits	297	Target Neighborhood Hits	193	Shared Neighborhood Hits	150
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

LIN7B_HUMAN
θ value	5.81887e-07 (rank : 54)	NC score	0.708892 (rank : 16)
Query Neighborhood Hits	297	Target Neighborhood Hits	200	Shared Neighborhood Hits	151
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

LIN7B_MOUSE
θ value	5.81887e-07 (rank : 55)	NC score	0.708564 (rank : 17)
Query Neighborhood Hits	297	Target Neighborhood Hits	200	Shared Neighborhood Hits	151
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

STXB4_HUMAN
θ value	5.81887e-07 (rank : 56)	NC score	0.439351 (rank : 97)
Query Neighborhood Hits	297	Target Neighborhood Hits	616	Shared Neighborhood Hits	130
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

DVL1L_HUMAN
θ value	7.59969e-07 (rank : 57)	NC score	0.498668 (rank : 84)
Query Neighborhood Hits	297	Target Neighborhood Hits	146	Shared Neighborhood Hits	114
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

DVL1_HUMAN
θ value	7.59969e-07 (rank : 58)	NC score	0.512625 (rank : 74)
Query Neighborhood Hits	297	Target Neighborhood Hits	158	Shared Neighborhood Hits	121
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

PDZK4_MOUSE
θ value	7.59969e-07 (rank : 59)	NC score	0.498297 (rank : 85)
Query Neighborhood Hits	297	Target Neighborhood Hits	165	Shared Neighborhood Hits	119
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

K1849_HUMAN
θ value	9.92553e-07 (rank : 60)	NC score	0.567069 (rank : 57)
Query Neighborhood Hits	297	Target Neighborhood Hits	220	Shared Neighborhood Hits	132
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

K1849_MOUSE
θ value	9.92553e-07 (rank : 61)	NC score	0.549158 (rank : 62)
Query Neighborhood Hits	297	Target Neighborhood Hits	335	Shared Neighborhood Hits	148
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

NHRF2_MOUSE
θ value	9.92553e-07 (rank : 62)	NC score	0.608173 (rank : 46)
Query Neighborhood Hits	297	Target Neighborhood Hits	194	Shared Neighborhood Hits	135
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

PDZD3_MOUSE
θ value	1.29631e-06 (rank : 63)	NC score	0.574955 (rank : 54)
Query Neighborhood Hits	297	Target Neighborhood Hits	171	Shared Neighborhood Hits	125
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

PDZK4_HUMAN
θ value	1.29631e-06 (rank : 64)	NC score	0.501193 (rank : 83)
Query Neighborhood Hits	297	Target Neighborhood Hits	165	Shared Neighborhood Hits	113
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

STXB4_MOUSE
θ value	1.29631e-06 (rank : 65)	NC score	0.439015 (rank : 99)
Query Neighborhood Hits	297	Target Neighborhood Hits	629	Shared Neighborhood Hits	125
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

DLG5_HUMAN
θ value	1.69304e-06 (rank : 66)	NC score	0.445171 (rank : 96)
Query Neighborhood Hits	297	Target Neighborhood Hits	1088	Shared Neighborhood Hits	187
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

LIN7C_HUMAN
θ value	2.88788e-06 (rank : 67)	NC score	0.706336 (rank : 19)
Query Neighborhood Hits	297	Target Neighborhood Hits	198	Shared Neighborhood Hits	151
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
θ value	2.88788e-06 (rank : 68)	NC score	0.706336 (rank : 20)
Query Neighborhood Hits	297	Target Neighborhood Hits	198	Shared Neighborhood Hits	151
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

ZO1_MOUSE
θ value	3.77169e-06 (rank : 69)	NC score	0.530881 (rank : 66)
Query Neighborhood Hits	297	Target Neighborhood Hits	453	Shared Neighborhood Hits	152
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

DVL2_MOUSE
θ value	6.43352e-06 (rank : 70)	NC score	0.493177 (rank : 86)
Query Neighborhood Hits	297	Target Neighborhood Hits	233	Shared Neighborhood Hits	119
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_HUMAN
θ value	8.40245e-06 (rank : 71)	NC score	0.492865 (rank : 87)
Query Neighborhood Hits	297	Target Neighborhood Hits	223	Shared Neighborhood Hits	118
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

NHERF_HUMAN
θ value	8.40245e-06 (rank : 72)	NC score	0.602835 (rank : 47)
Query Neighborhood Hits	297	Target Neighborhood Hits	190	Shared Neighborhood Hits	126
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

PDZD3_HUMAN
θ value	1.43324e-05 (rank : 73)	NC score	0.597249 (rank : 48)
Query Neighborhood Hits	297	Target Neighborhood Hits	180	Shared Neighborhood Hits	128
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

DVL3_HUMAN
θ value	4.1701e-05 (rank : 74)	NC score	0.509095 (rank : 77)
Query Neighborhood Hits	297	Target Neighborhood Hits	194	Shared Neighborhood Hits	115
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_MOUSE
θ value	4.1701e-05 (rank : 75)	NC score	0.510280 (rank : 76)
Query Neighborhood Hits	297	Target Neighborhood Hits	198	Shared Neighborhood Hits	114
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

ARHGC_MOUSE
θ value	5.44631e-05 (rank : 76)	NC score	0.306471 (rank : 129)
Query Neighborhood Hits	297	Target Neighborhood Hits	344	Shared Neighborhood Hits	128
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_HUMAN
θ value	0.000121331 (rank : 77)	NC score	0.307277 (rank : 128)
Query Neighborhood Hits	297	Target Neighborhood Hits	351	Shared Neighborhood Hits	127
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

APBA2_HUMAN
θ value	0.000270298 (rank : 78)	NC score	0.437767 (rank : 100)
Query Neighborhood Hits	297	Target Neighborhood Hits	220	Shared Neighborhood Hits	131
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_MOUSE
θ value	0.000270298 (rank : 79)	NC score	0.439171 (rank : 98)
Query Neighborhood Hits	297	Target Neighborhood Hits	219	Shared Neighborhood Hits	130
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA3_HUMAN
θ value	0.000270298 (rank : 80)	NC score	0.431738 (rank : 106)
Query Neighborhood Hits	297	Target Neighborhood Hits	201	Shared Neighborhood Hits	120
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

ARHGB_HUMAN
θ value	0.000270298 (rank : 81)	NC score	0.324019 (rank : 123)
Query Neighborhood Hits	297	Target Neighborhood Hits	375	Shared Neighborhood Hits	140
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

SNTA1_MOUSE
θ value	0.000270298 (rank : 82)	NC score	0.525364 (rank : 69)
Query Neighborhood Hits	297	Target Neighborhood Hits	170	Shared Neighborhood Hits	130
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

SNTG2_HUMAN
θ value	0.00035302 (rank : 83)	NC score	0.563788 (rank : 58)
Query Neighborhood Hits	297	Target Neighborhood Hits	191	Shared Neighborhood Hits	147
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

APBA1_HUMAN
θ value	0.000461057 (rank : 84)	NC score	0.449692 (rank : 94)
Query Neighborhood Hits	297	Target Neighborhood Hits	325	Shared Neighborhood Hits	141
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

NOS1_HUMAN
θ value	0.000461057 (rank : 85)	NC score	0.329049 (rank : 121)
Query Neighborhood Hits	297	Target Neighborhood Hits	218	Shared Neighborhood Hits	135
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

SNTA1_HUMAN
θ value	0.000602161 (rank : 86)	NC score	0.528686 (rank : 67)
Query Neighborhood Hits	297	Target Neighborhood Hits	186	Shared Neighborhood Hits	137
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

SNTB2_HUMAN
θ value	0.000602161 (rank : 87)	NC score	0.540471 (rank : 65)
Query Neighborhood Hits	297	Target Neighborhood Hits	180	Shared Neighborhood Hits	139
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

ZO1_HUMAN
θ value	0.000786445 (rank : 88)	NC score	0.521906 (rank : 71)
Query Neighborhood Hits	297	Target Neighborhood Hits	474	Shared Neighborhood Hits	155
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

CSKP_HUMAN
θ value	0.00134147 (rank : 89)	NC score	0.125976 (rank : 176)
Query Neighborhood Hits	297	Target Neighborhood Hits	1022	Shared Neighborhood Hits	115
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKP_MOUSE
θ value	0.00134147 (rank : 90)	NC score	0.122657 (rank : 177)
Query Neighborhood Hits	297	Target Neighborhood Hits	1027	Shared Neighborhood Hits	116
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

PAR6B_HUMAN
θ value	0.00134147 (rank : 91)	NC score	0.432523 (rank : 103)
Query Neighborhood Hits	297	Target Neighborhood Hits	126	Shared Neighborhood Hits	115
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

APBA3_MOUSE
θ value	0.00175202 (rank : 92)	NC score	0.404052 (rank : 113)
Query Neighborhood Hits	297	Target Neighborhood Hits	174	Shared Neighborhood Hits	117
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

SNTB2_MOUSE
θ value	0.00175202 (rank : 93)	NC score	0.540485 (rank : 64)
Query Neighborhood Hits	297	Target Neighborhood Hits	181	Shared Neighborhood Hits	138
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

ZO2_HUMAN
θ value	0.00175202 (rank : 94)	NC score	0.515651 (rank : 73)
Query Neighborhood Hits	297	Target Neighborhood Hits	289	Shared Neighborhood Hits	148
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZO2_MOUSE
θ value	0.00175202 (rank : 95)	NC score	0.517537 (rank : 72)
Query Neighborhood Hits	297	Target Neighborhood Hits	296	Shared Neighborhood Hits	147
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

MPP3_HUMAN
θ value	0.00228821 (rank : 96)	NC score	0.427857 (rank : 108)
Query Neighborhood Hits	297	Target Neighborhood Hits	171	Shared Neighborhood Hits	127
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

RIMS1_HUMAN
θ value	0.00228821 (rank : 97)	NC score	0.268044 (rank : 139)
Query Neighborhood Hits	297	Target Neighborhood Hits	437	Shared Neighborhood Hits	122
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

SNTG2_MOUSE
θ value	0.00228821 (rank : 98)	NC score	0.526983 (rank : 68)
Query Neighborhood Hits	297	Target Neighborhood Hits	176	Shared Neighborhood Hits	136
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

IF2M_MOUSE
θ value	0.00298849 (rank : 99)	NC score	0.051267 (rank : 221)
Query Neighborhood Hits	297	Target Neighborhood Hits	183	Shared Neighborhood Hits	10
SwissProt Accessions	Q91YJ5	Gene names	Mtif2
Domain Architecture
Description	Translation initiation factor IF-2, mitochondrial precursor (IF-2Mt) (IF-2(Mt)).

MPP4_HUMAN
θ value	0.00298849 (rank : 100)	NC score	0.468749 (rank : 92)
Query Neighborhood Hits	297	Target Neighborhood Hits	205	Shared Neighborhood Hits	128
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

NOS1_MOUSE
θ value	0.00298849 (rank : 101)	NC score	0.291739 (rank : 132)
Query Neighborhood Hits	297	Target Neighborhood Hits	155	Shared Neighborhood Hits	109
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

SNTB1_HUMAN
θ value	0.00298849 (rank : 102)	NC score	0.505199 (rank : 80)
Query Neighborhood Hits	297	Target Neighborhood Hits	157	Shared Neighborhood Hits	127
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

SNTB1_MOUSE
θ value	0.00298849 (rank : 103)	NC score	0.503998 (rank : 81)
Query Neighborhood Hits	297	Target Neighborhood Hits	160	Shared Neighborhood Hits	125
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

MPP3_MOUSE
θ value	0.00390308 (rank : 104)	NC score	0.432045 (rank : 104)
Query Neighborhood Hits	297	Target Neighborhood Hits	165	Shared Neighborhood Hits	127
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

HUTH_MOUSE
θ value	0.00509761 (rank : 105)	NC score	0.074577 (rank : 197)
Query Neighborhood Hits	297	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	P35492	Gene names	Hal, Hsd, Huth
Domain Architecture
Description	Histidine ammonia-lyase (EC 4.3.1.3) (Histidase).

RGS3_HUMAN
θ value	0.00509761 (rank : 106)	NC score	0.092455 (rank : 187)
Query Neighborhood Hits	297	Target Neighborhood Hits	1375	Shared Neighborhood Hits	100
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

ZO3_MOUSE
θ value	0.00509761 (rank : 107)	NC score	0.553425 (rank : 60)
Query Neighborhood Hits	297	Target Neighborhood Hits	224	Shared Neighborhood Hits	148
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

PAR6B_MOUSE
θ value	0.00665767 (rank : 108)	NC score	0.424897 (rank : 109)
Query Neighborhood Hits	297	Target Neighborhood Hits	128	Shared Neighborhood Hits	116
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

RHPN1_MOUSE
θ value	0.00869519 (rank : 109)	NC score	0.326225 (rank : 122)
Query Neighborhood Hits	297	Target Neighborhood Hits	154	Shared Neighborhood Hits	98
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

RIMS2_HUMAN
θ value	0.00869519 (rank : 110)	NC score	0.229092 (rank : 150)
Query Neighborhood Hits	297	Target Neighborhood Hits	342	Shared Neighborhood Hits	104
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	0.00869519 (rank : 111)	NC score	0.226313 (rank : 151)
Query Neighborhood Hits	297	Target Neighborhood Hits	376	Shared Neighborhood Hits	105
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

EM55_MOUSE
θ value	0.0113563 (rank : 112)	NC score	0.379482 (rank : 116)
Query Neighborhood Hits	297	Target Neighborhood Hits	221	Shared Neighborhood Hits	118
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

PAR6G_HUMAN
θ value	0.0113563 (rank : 113)	NC score	0.424439 (rank : 110)
Query Neighborhood Hits	297	Target Neighborhood Hits	159	Shared Neighborhood Hits	118
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

PAR6G_MOUSE
θ value	0.0113563 (rank : 114)	NC score	0.423689 (rank : 111)
Query Neighborhood Hits	297	Target Neighborhood Hits	121	Shared Neighborhood Hits	113
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

MPP5_HUMAN
θ value	0.0148317 (rank : 115)	NC score	0.432822 (rank : 102)
Query Neighborhood Hits	297	Target Neighborhood Hits	231	Shared Neighborhood Hits	134
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	0.0148317 (rank : 116)	NC score	0.431651 (rank : 107)
Query Neighborhood Hits	297	Target Neighborhood Hits	226	Shared Neighborhood Hits	134
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

SNTG1_HUMAN
θ value	0.0148317 (rank : 117)	NC score	0.508207 (rank : 78)
Query Neighborhood Hits	297	Target Neighborhood Hits	181	Shared Neighborhood Hits	138
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTG1_MOUSE
θ value	0.0148317 (rank : 118)	NC score	0.506911 (rank : 79)
Query Neighborhood Hits	297	Target Neighborhood Hits	179	Shared Neighborhood Hits	137
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

PDZ11_HUMAN
θ value	0.0193708 (rank : 119)	NC score	0.575776 (rank : 53)
Query Neighborhood Hits	297	Target Neighborhood Hits	160	Shared Neighborhood Hits	117
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

LRRC7_HUMAN
θ value	0.0252991 (rank : 120)	NC score	0.235129 (rank : 148)
Query Neighborhood Hits	297	Target Neighborhood Hits	423	Shared Neighborhood Hits	109
SwissProt Accessions	Q96NW7, Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2	Gene names	LRRC7, KIAA1365, LAP1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

LRRC7_MOUSE
θ value	0.0252991 (rank : 121)	NC score	0.234172 (rank : 149)
Query Neighborhood Hits	297	Target Neighborhood Hits	416	Shared Neighborhood Hits	107
SwissProt Accessions	Q80TE7	Gene names	Lrrc7, Kiaa1365, Lap1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

RHPN1_HUMAN
θ value	0.0252991 (rank : 122)	NC score	0.295123 (rank : 131)
Query Neighborhood Hits	297	Target Neighborhood Hits	158	Shared Neighborhood Hits	90
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

DMP1_HUMAN
θ value	0.0330416 (rank : 123)	NC score	0.049414 (rank : 228)
Query Neighborhood Hits	297	Target Neighborhood Hits	491	Shared Neighborhood Hits	21
SwissProt Accessions	Q13316, O43265	Gene names	DMP1
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1).

PICK1_HUMAN
θ value	0.0330416 (rank : 124)	NC score	0.433032 (rank : 101)
Query Neighborhood Hits	297	Target Neighborhood Hits	132	Shared Neighborhood Hits	114
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

TCAL5_HUMAN
θ value	0.0330416 (rank : 125)	NC score	0.036772 (rank : 252)
Query Neighborhood Hits	297	Target Neighborhood Hits	806	Shared Neighborhood Hits	43
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

ZIM10_MOUSE
θ value	0.0330416 (rank : 126)	NC score	0.039568 (rank : 242)
Query Neighborhood Hits	297	Target Neighborhood Hits	430	Shared Neighborhood Hits	39
SwissProt Accessions	Q6P1E1, Q6PDK9, Q6PF85, Q8BW47	Gene names	Rai17, Zimp10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

ZO3_HUMAN
θ value	0.0330416 (rank : 127)	NC score	0.546935 (rank : 63)
Query Neighborhood Hits	297	Target Neighborhood Hits	219	Shared Neighborhood Hits	143
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

CO5A1_MOUSE
θ value	0.0431538 (rank : 128)	NC score	0.038628 (rank : 247)
Query Neighborhood Hits	297	Target Neighborhood Hits	419	Shared Neighborhood Hits	29
SwissProt Accessions	O88207	Gene names	Col5a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(V) chain precursor.

EM55_HUMAN
θ value	0.0431538 (rank : 129)	NC score	0.378845 (rank : 117)
Query Neighborhood Hits	297	Target Neighborhood Hits	228	Shared Neighborhood Hits	120
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

GOPC_HUMAN
θ value	0.0431538 (rank : 130)	NC score	0.570816 (rank : 56)
Query Neighborhood Hits	297	Target Neighborhood Hits	377	Shared Neighborhood Hits	155
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

GOPC_MOUSE
θ value	0.0431538 (rank : 131)	NC score	0.579774 (rank : 52)
Query Neighborhood Hits	297	Target Neighborhood Hits	323	Shared Neighborhood Hits	150
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

PTN4_HUMAN
θ value	0.0431538 (rank : 132)	NC score	0.146577 (rank : 170)
Query Neighborhood Hits	297	Target Neighborhood Hits	303	Shared Neighborhood Hits	102
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

CO5A1_HUMAN
θ value	0.0563607 (rank : 133)	NC score	0.038632 (rank : 246)
Query Neighborhood Hits	297	Target Neighborhood Hits	434	Shared Neighborhood Hits	29
SwissProt Accessions	P20908, Q15094, Q5SUX4	Gene names	COL5A1
Domain Architecture
Description	Collagen alpha-1(V) chain precursor.

MPP4_MOUSE
θ value	0.0563607 (rank : 134)	NC score	0.422295 (rank : 112)
Query Neighborhood Hits	297	Target Neighborhood Hits	188	Shared Neighborhood Hits	114
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

PDZ11_MOUSE
θ value	0.0563607 (rank : 135)	NC score	0.571240 (rank : 55)
Query Neighborhood Hits	297	Target Neighborhood Hits	154	Shared Neighborhood Hits	112
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PAR6A_HUMAN
θ value	0.0736092 (rank : 136)	NC score	0.402166 (rank : 115)
Query Neighborhood Hits	297	Target Neighborhood Hits	119	Shared Neighborhood Hits	107
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

PAR6A_MOUSE
θ value	0.0736092 (rank : 137)	NC score	0.402208 (rank : 114)
Query Neighborhood Hits	297	Target Neighborhood Hits	115	Shared Neighborhood Hits	107
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

PCLO_MOUSE
θ value	0.0736092 (rank : 138)	NC score	0.200046 (rank : 159)
Query Neighborhood Hits	297	Target Neighborhood Hits	2275	Shared Neighborhood Hits	201
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PICK1_MOUSE
θ value	0.0736092 (rank : 139)	NC score	0.431950 (rank : 105)
Query Neighborhood Hits	297	Target Neighborhood Hits	131	Shared Neighborhood Hits	113
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

SHAN1_HUMAN
θ value	0.0736092 (rank : 140)	NC score	0.169387 (rank : 162)
Query Neighborhood Hits	297	Target Neighborhood Hits	1041	Shared Neighborhood Hits	135
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

GIPC1_MOUSE
θ value	0.0961366 (rank : 141)	NC score	0.235629 (rank : 147)
Query Neighborhood Hits	297	Target Neighborhood Hits	92	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Z0G0	Gene names	Gipc1, Gipc, Rgs19ip1, Semcap1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Synectin) (SemaF cytoplasmic domain-associated protein 1) (SEMCAP-1).

HUTH_HUMAN
θ value	0.0961366 (rank : 142)	NC score	0.065348 (rank : 201)
Query Neighborhood Hits	297	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	P42357	Gene names	HAL, HIS
Domain Architecture
Description	Histidine ammonia-lyase (EC 4.3.1.3) (Histidase).

TTF2_MOUSE
θ value	0.0961366 (rank : 143)	NC score	0.025149 (rank : 285)
Query Neighborhood Hits	297	Target Neighborhood Hits	364	Shared Neighborhood Hits	28
SwissProt Accessions	Q5NC05, Q5M924	Gene names	Ttf2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2).

PTN3_HUMAN
θ value	0.125558 (rank : 144)	NC score	0.137485 (rank : 172)
Query Neighborhood Hits	297	Target Neighborhood Hits	258	Shared Neighborhood Hits	98
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

IKKB_MOUSE
θ value	0.163984 (rank : 145)	NC score	0.004752 (rank : 347)
Query Neighborhood Hits	297	Target Neighborhood Hits	984	Shared Neighborhood Hits	29
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

SMC1A_HUMAN
θ value	0.163984 (rank : 146)	NC score	0.038850 (rank : 245)
Query Neighborhood Hits	297	Target Neighborhood Hits	1346	Shared Neighborhood Hits	69
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

SMC1A_MOUSE
θ value	0.163984 (rank : 147)	NC score	0.037277 (rank : 251)
Query Neighborhood Hits	297	Target Neighborhood Hits	1384	Shared Neighborhood Hits	70
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

CCD93_HUMAN
θ value	0.21417 (rank : 148)	NC score	0.048984 (rank : 230)
Query Neighborhood Hits	297	Target Neighborhood Hits	600	Shared Neighborhood Hits	44
SwissProt Accessions	Q567U6, Q4LE78, Q53TJ2, Q8TBX5, Q9H6R5, Q9NV15	Gene names	CCDC93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

PDLI2_HUMAN
θ value	0.21417 (rank : 149)	NC score	0.310216 (rank : 127)
Query Neighborhood Hits	297	Target Neighborhood Hits	245	Shared Neighborhood Hits	99
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

RGS3_MOUSE
θ value	0.21417 (rank : 150)	NC score	0.085200 (rank : 193)
Query Neighborhood Hits	297	Target Neighborhood Hits	1621	Shared Neighborhood Hits	117
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

WIRE_MOUSE
θ value	0.21417 (rank : 151)	NC score	0.051989 (rank : 219)
Query Neighborhood Hits	297	Target Neighborhood Hits	310	Shared Neighborhood Hits	22
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

CCD93_MOUSE
θ value	0.279714 (rank : 152)	NC score	0.053922 (rank : 212)
Query Neighborhood Hits	297	Target Neighborhood Hits	362	Shared Neighborhood Hits	38
SwissProt Accessions	Q7TQK5, Q3TX53	Gene names	Ccdc93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

CIKS_HUMAN
θ value	0.279714 (rank : 153)	NC score	0.049587 (rank : 227)
Query Neighborhood Hits	297	Target Neighborhood Hits	60	Shared Neighborhood Hits	9
SwissProt Accessions	O43734, Q5R3A3, Q9H5W2, Q9H6Y3, Q9NS14, Q9UG72	Gene names	TRAF3IP2, C6orf4, C6orf5
Domain Architecture	No domain graphic available
Description	Adapter protein CIKS (Connection to IKK and SAPK/JNK) (TRAF3- interacting protein 2) (Nuclear factor NF-kappa-B activator 1) (ACT1).

GIPC1_HUMAN
θ value	0.279714 (rank : 154)	NC score	0.221121 (rank : 153)
Query Neighborhood Hits	297	Target Neighborhood Hits	91	Shared Neighborhood Hits	79
SwissProt Accessions	O14908, Q9BTC9	Gene names	GIPC1, C19orf3, GIPC, RGS19IP1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Tax interaction protein 2) (TIP-2).

NU214_HUMAN
θ value	0.279714 (rank : 155)	NC score	0.038566 (rank : 248)
Query Neighborhood Hits	297	Target Neighborhood Hits	657	Shared Neighborhood Hits	33
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

PHLB1_HUMAN
θ value	0.279714 (rank : 156)	NC score	0.037703 (rank : 249)
Query Neighborhood Hits	297	Target Neighborhood Hits	1038	Shared Neighborhood Hits	69
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

GLIS3_MOUSE
θ value	0.365318 (rank : 157)	NC score	-0.002809 (rank : 361)
Query Neighborhood Hits	297	Target Neighborhood Hits	861	Shared Neighborhood Hits	17
SwissProt Accessions	Q6XP49, Q8BI60	Gene names	Glis3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS3 (GLI-similar 3).

LAP2_HUMAN
θ value	0.365318 (rank : 158)	NC score	0.222162 (rank : 152)
Query Neighborhood Hits	297	Target Neighborhood Hits	499	Shared Neighborhood Hits	111
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

MY18A_HUMAN
θ value	0.365318 (rank : 159)	NC score	0.085272 (rank : 192)
Query Neighborhood Hits	297	Target Neighborhood Hits	1929	Shared Neighborhood Hits	174
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MY18A_MOUSE
θ value	0.365318 (rank : 160)	NC score	0.091225 (rank : 188)
Query Neighborhood Hits	297	Target Neighborhood Hits	1989	Shared Neighborhood Hits	169
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

CABIN_HUMAN
θ value	0.47712 (rank : 161)	NC score	0.042697 (rank : 236)
Query Neighborhood Hits	297	Target Neighborhood Hits	490	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

FLIP1_HUMAN
θ value	0.47712 (rank : 162)	NC score	0.036232 (rank : 253)
Query Neighborhood Hits	297	Target Neighborhood Hits	1405	Shared Neighborhood Hits	67
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

GOGA4_HUMAN
θ value	0.47712 (rank : 163)	NC score	0.039415 (rank : 244)
Query Neighborhood Hits	297	Target Neighborhood Hits	2034	Shared Neighborhood Hits	86
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

PHF20_HUMAN
θ value	0.47712 (rank : 164)	NC score	0.035160 (rank : 256)
Query Neighborhood Hits	297	Target Neighborhood Hits	394	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BVI0, Q5JWY9, Q9BWV4, Q9BXA3, Q9BZW3, Q9H421, Q9H4J6, Q9NZ22	Gene names	PHF20, C20orf104, GLEA2, HCA58, NZF, TZP
Domain Architecture
Description	PHD finger protein 20 (Hepatocellular carcinoma-associated antigen 58) (Glioma-expressed antigen 2) (Transcription factor TZP) (Novel zinc finger protein).

ZEP2_HUMAN
θ value	0.47712 (rank : 165)	NC score	0.004709 (rank : 348)
Query Neighborhood Hits	297	Target Neighborhood Hits	937	Shared Neighborhood Hits	25
SwissProt Accessions	P31629, Q02646, Q5THT5, Q9NS05	Gene names	HIVEP2
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 (HIV- EP2) (MHC-binding protein 2) (MBP-2).

CT2NL_HUMAN
θ value	0.62314 (rank : 166)	NC score	0.030625 (rank : 274)
Query Neighborhood Hits	297	Target Neighborhood Hits	1059	Shared Neighborhood Hits	57
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

RPGF6_HUMAN
θ value	0.62314 (rank : 167)	NC score	0.331083 (rank : 120)
Query Neighborhood Hits	297	Target Neighborhood Hits	266	Shared Neighborhood Hits	125
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

41_MOUSE
θ value	0.813845 (rank : 168)	NC score	0.039954 (rank : 239)
Query Neighborhood Hits	297	Target Neighborhood Hits	184	Shared Neighborhood Hits	12
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

CCD21_HUMAN
θ value	0.813845 (rank : 169)	NC score	0.033751 (rank : 258)
Query Neighborhood Hits	297	Target Neighborhood Hits	1228	Shared Neighborhood Hits	65
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CTGE4_HUMAN
θ value	0.813845 (rank : 170)	NC score	0.032346 (rank : 264)
Query Neighborhood Hits	297	Target Neighborhood Hits	393	Shared Neighborhood Hits	34
SwissProt Accessions	Q8IX94, O95046	Gene names	CTAGE4
Domain Architecture	No domain graphic available
Description	Cutaneous T-cell lymphoma-associated antigen 4 (cTAGE-4 protein).

FA12_HUMAN
θ value	0.813845 (rank : 171)	NC score	-0.000224 (rank : 355)
Query Neighborhood Hits	297	Target Neighborhood Hits	425	Shared Neighborhood Hits	4
SwissProt Accessions	P00748, P78339	Gene names	F12
Domain Architecture
Description	Coagulation factor XII precursor (EC 3.4.21.38) (Hageman factor) (HAF) [Contains: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Beta-factor XIIa part 2; Coagulation factor XIIa light chain].

FLIP1_MOUSE
θ value	0.813845 (rank : 172)	NC score	0.039538 (rank : 243)
Query Neighborhood Hits	297	Target Neighborhood Hits	1176	Shared Neighborhood Hits	62
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

IKKB_HUMAN
θ value	0.813845 (rank : 173)	NC score	0.003112 (rank : 351)
Query Neighborhood Hits	297	Target Neighborhood Hits	980	Shared Neighborhood Hits	29
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

PODXL_MOUSE
θ value	0.813845 (rank : 174)	NC score	0.031015 (rank : 271)
Query Neighborhood Hits	297	Target Neighborhood Hits	130	Shared Neighborhood Hits	7
SwissProt Accessions	Q9R0M4, Q9ESZ1	Gene names	Podxl, Pclp1
Domain Architecture
Description	Podocalyxin-like protein 1 precursor.

RB6I2_HUMAN
θ value	0.813845 (rank : 175)	NC score	0.031340 (rank : 269)
Query Neighborhood Hits	297	Target Neighborhood Hits	1584	Shared Neighborhood Hits	71
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

RPGF2_HUMAN
θ value	0.813845 (rank : 176)	NC score	0.283468 (rank : 135)
Query Neighborhood Hits	297	Target Neighborhood Hits	242	Shared Neighborhood Hits	121
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

WIRE_HUMAN
θ value	0.813845 (rank : 177)	NC score	0.046792 (rank : 232)
Query Neighborhood Hits	297	Target Neighborhood Hits	329	Shared Neighborhood Hits	23
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

COBA1_HUMAN
θ value	1.06291 (rank : 178)	NC score	0.031517 (rank : 268)
Query Neighborhood Hits	297	Target Neighborhood Hits	491	Shared Neighborhood Hits	36
SwissProt Accessions	P12107, Q14034, Q9UIT4, Q9UIT5, Q9UIT6	Gene names	COL11A1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

COBA1_MOUSE
θ value	1.06291 (rank : 179)	NC score	0.030787 (rank : 272)
Query Neighborhood Hits	297	Target Neighborhood Hits	487	Shared Neighborhood Hits	37
SwissProt Accessions	Q61245, Q64047	Gene names	Col11a1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

PDZD6_HUMAN
θ value	1.06291 (rank : 180)	NC score	0.213998 (rank : 156)
Query Neighborhood Hits	297	Target Neighborhood Hits	81	Shared Neighborhood Hits	54
SwissProt Accessions	Q9ULD6, Q4W5I8, Q86V55	Gene names	PDZD6, KIAA1284, PDZK6
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 6.

RRBP1_HUMAN
θ value	1.06291 (rank : 181)	NC score	0.033200 (rank : 260)
Query Neighborhood Hits	297	Target Neighborhood Hits	1306	Shared Neighborhood Hits	77
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

ANLN_MOUSE
θ value	1.38821 (rank : 182)	NC score	0.021755 (rank : 292)
Query Neighborhood Hits	297	Target Neighborhood Hits	297	Shared Neighborhood Hits	19
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

ITIH1_MOUSE
θ value	1.38821 (rank : 183)	NC score	0.012077 (rank : 327)
Query Neighborhood Hits	297	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q61702	Gene names	Itih1
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H1 precursor (ITI heavy chain H1) (Inter-alpha-inhibitor heavy chain 1).

PHF20_MOUSE
θ value	1.38821 (rank : 184)	NC score	0.028956 (rank : 279)
Query Neighborhood Hits	297	Target Neighborhood Hits	513	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BLG0, Q8BMA2, Q8BYR4, Q921N1	Gene names	Phf20, Hca58
Domain Architecture
Description	PHD finger protein 20 (Hepatocellular carcinoma-associated antigen 58 homolog).

SMC3_HUMAN
θ value	1.38821 (rank : 185)	NC score	0.039759 (rank : 241)
Query Neighborhood Hits	297	Target Neighborhood Hits	1186	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

SMC3_MOUSE
θ value	1.38821 (rank : 186)	NC score	0.039768 (rank : 240)
Query Neighborhood Hits	297	Target Neighborhood Hits	1187	Shared Neighborhood Hits	62
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

TACC3_HUMAN
θ value	1.38821 (rank : 187)	NC score	0.041374 (rank : 237)
Query Neighborhood Hits	297	Target Neighborhood Hits	779	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

TX1B3_HUMAN
θ value	1.38821 (rank : 188)	NC score	0.558477 (rank : 59)
Query Neighborhood Hits	297	Target Neighborhood Hits	161	Shared Neighborhood Hits	129
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
θ value	1.38821 (rank : 189)	NC score	0.553374 (rank : 61)
Query Neighborhood Hits	297	Target Neighborhood Hits	158	Shared Neighborhood Hits	126
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

E41LA_HUMAN
θ value	1.81305 (rank : 190)	NC score	0.044639 (rank : 234)
Query Neighborhood Hits	297	Target Neighborhood Hits	87	Shared Neighborhood Hits	13
SwissProt Accessions	Q9HCS5	Gene names	EPB41L4A, EPB41L4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

HOOK3_MOUSE
θ value	1.81305 (rank : 191)	NC score	0.032775 (rank : 262)
Query Neighborhood Hits	297	Target Neighborhood Hits	1007	Shared Neighborhood Hits	65
SwissProt Accessions	Q8BUK6, Q8BV48, Q8BW57, Q8BY41	Gene names	Hook3
Domain Architecture
Description	Hook homolog 3.

SLK_HUMAN
θ value	1.81305 (rank : 192)	NC score	0.004805 (rank : 346)
Query Neighborhood Hits	297	Target Neighborhood Hits	1775	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

SLK_MOUSE
θ value	1.81305 (rank : 193)	NC score	0.005063 (rank : 344)
Query Neighborhood Hits	297	Target Neighborhood Hits	1798	Shared Neighborhood Hits	67
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

PRPC_HUMAN
θ value	2.36792 (rank : 194)	NC score	0.048080 (rank : 231)
Query Neighborhood Hits	297	Target Neighborhood Hits	165	Shared Neighborhood Hits	19
SwissProt Accessions	P02810, Q4VBP2, Q53XA2, Q6P2F6	Gene names	PRH1
Domain Architecture	No domain graphic available
Description	Salivary acidic proline-rich phosphoprotein 1/2 precursor (PRP-1/PRP- 2) (Parotid proline-rich protein 1/2) (Pr1/Pr2) (Protein C) (Parotid acidic protein) (Pa) (Parotid isoelectric focusing variant protein) (PIF-S) (Parotid double-band protein) (Db-s) [Contains: Salivary acidic proline-rich phosphoprotein 1/2; Salivary acidic proline-rich phosphoprotein 3/4 (PRP-3/PRP-4) (Protein A) (PIF-F) (Db-F); Peptide P-C].

RPTN_MOUSE
θ value	2.36792 (rank : 195)	NC score	0.045242 (rank : 233)
Query Neighborhood Hits	297	Target Neighborhood Hits	650	Shared Neighborhood Hits	45
SwissProt Accessions	P97347	Gene names	Rptn
Domain Architecture
Description	Repetin.

RRBP1_MOUSE
θ value	2.36792 (rank : 196)	NC score	0.035227 (rank : 255)
Query Neighborhood Hits	297	Target Neighborhood Hits	1650	Shared Neighborhood Hits	94
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

TEX14_MOUSE
θ value	2.36792 (rank : 197)	NC score	0.006528 (rank : 340)
Query Neighborhood Hits	297	Target Neighborhood Hits	1333	Shared Neighborhood Hits	41
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

ARHGA_HUMAN
θ value	3.0926 (rank : 198)	NC score	0.019500 (rank : 299)
Query Neighborhood Hits	297	Target Neighborhood Hits	187	Shared Neighborhood Hits	10
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

BTBD7_MOUSE
θ value	3.0926 (rank : 199)	NC score	0.013802 (rank : 321)
Query Neighborhood Hits	297	Target Neighborhood Hits	228	Shared Neighborhood Hits	14
SwissProt Accessions	Q8CFE5, Q80TC3, Q8BZY9	Gene names	Btbd7, Kiaa1525
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 7.

CCD91_MOUSE
θ value	3.0926 (rank : 200)	NC score	0.026762 (rank : 282)
Query Neighborhood Hits	297	Target Neighborhood Hits	699	Shared Neighborhood Hits	48
SwissProt Accessions	Q9D8L5, Q8R3N8, Q9D9E8	Gene names	Ccdc91, Ggabp
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner).

CO4A2_HUMAN
θ value	3.0926 (rank : 201)	NC score	0.019523 (rank : 298)
Query Neighborhood Hits	297	Target Neighborhood Hits	454	Shared Neighborhood Hits	33
SwissProt Accessions	P08572	Gene names	COL4A2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

COAA1_MOUSE
θ value	3.0926 (rank : 202)	NC score	0.019778 (rank : 296)
Query Neighborhood Hits	297	Target Neighborhood Hits	286	Shared Neighborhood Hits	23
SwissProt Accessions	Q05306	Gene names	Col10a1
Domain Architecture
Description	Collagen alpha-1(X) chain precursor.

ETV3_MOUSE
θ value	3.0926 (rank : 203)	NC score	0.009951 (rank : 333)
Query Neighborhood Hits	297	Target Neighborhood Hits	128	Shared Neighborhood Hits	7
SwissProt Accessions	Q8R4Z4, Q9QZW1	Gene names	Etv3, Mets, Pe1
Domain Architecture	No domain graphic available
Description	ETS translocation variant 3 (ETS-domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor).

GOGA4_MOUSE
θ value	3.0926 (rank : 204)	NC score	0.035281 (rank : 254)
Query Neighborhood Hits	297	Target Neighborhood Hits	1939	Shared Neighborhood Hits	86
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

HCN2_HUMAN
θ value	3.0926 (rank : 205)	NC score	0.009739 (rank : 334)
Query Neighborhood Hits	297	Target Neighborhood Hits	369	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

ITSN1_MOUSE
θ value	3.0926 (rank : 206)	NC score	0.043122 (rank : 235)
Query Neighborhood Hits	297	Target Neighborhood Hits	1669	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

KIF4A_HUMAN
θ value	3.0926 (rank : 207)	NC score	0.019718 (rank : 297)
Query Neighborhood Hits	297	Target Neighborhood Hits	1159	Shared Neighborhood Hits	61
SwissProt Accessions	O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3	Gene names	KIF4A, KIF4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

KIF4A_MOUSE
θ value	3.0926 (rank : 208)	NC score	0.018796 (rank : 306)
Query Neighborhood Hits	297	Target Neighborhood Hits	1033	Shared Neighborhood Hits	59
SwissProt Accessions	P33174	Gene names	Kif4a, Kif4, Kns4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

LAP2_MOUSE
θ value	3.0926 (rank : 209)	NC score	0.208147 (rank : 157)
Query Neighborhood Hits	297	Target Neighborhood Hits	482	Shared Neighborhood Hits	104
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

PLCB2_HUMAN
θ value	3.0926 (rank : 210)	NC score	0.015132 (rank : 317)
Query Neighborhood Hits	297	Target Neighborhood Hits	608	Shared Neighborhood Hits	43
SwissProt Accessions	Q00722	Gene names	PLCB2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-2) (PLC-beta-2).

RFTN1_HUMAN
θ value	3.0926 (rank : 211)	NC score	0.014478 (rank : 319)
Query Neighborhood Hits	297	Target Neighborhood Hits	72	Shared Neighborhood Hits	4
SwissProt Accessions	Q14699, Q496Y2, Q4QQI7, Q5JB48, Q7Z7P2	Gene names	RFTN1, KIAA0084
Domain Architecture	No domain graphic available
Description	Raftlin (Raft-linking protein) (Cell migration-inducing gene 2 protein).

SDCB1_HUMAN
θ value	3.0926 (rank : 212)	NC score	0.333945 (rank : 119)
Query Neighborhood Hits	297	Target Neighborhood Hits	150	Shared Neighborhood Hits	122
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

SDCB1_MOUSE
θ value	3.0926 (rank : 213)	NC score	0.334607 (rank : 118)
Query Neighborhood Hits	297	Target Neighborhood Hits	144	Shared Neighborhood Hits	113
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

SF3B2_HUMAN
θ value	3.0926 (rank : 214)	NC score	0.033588 (rank : 259)
Query Neighborhood Hits	297	Target Neighborhood Hits	157	Shared Neighborhood Hits	15
SwissProt Accessions	Q13435	Gene names	SF3B2, SAP145
Domain Architecture
Description	Splicing factor 3B subunit 2 (Spliceosome-associated protein 145) (SAP 145) (SF3b150) (Pre-mRNA-splicing factor SF3b 145 kDa subunit).

SNPC1_HUMAN
θ value	3.0926 (rank : 215)	NC score	0.017975 (rank : 309)
Query Neighborhood Hits	297	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q16533	Gene names	SNAPC1, SNAP43
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 1 (SNAPc subunit 1) (snRNA- activating protein complex 43 kDa subunit) (SNAPc 43 kDa subunit) (Small nuclear RNA-activating complex polypeptide 1) (Proximal sequence element-binding transcription factor subunit gamma) (PSE- binding factor subunit gamma) (PTF subunit gamma).

SUHW4_MOUSE
θ value	3.0926 (rank : 216)	NC score	-0.002550 (rank : 360)
Query Neighborhood Hits	297	Target Neighborhood Hits	737	Shared Neighborhood Hits	11
SwissProt Accessions	Q68FE8, Q3T9B1, Q8BI82	Gene names	Suhw4
Domain Architecture	No domain graphic available
Description	Suppressor of hairy wing homolog 4.

TMC2_MOUSE
θ value	3.0926 (rank : 217)	NC score	0.013158 (rank : 325)
Query Neighborhood Hits	297	Target Neighborhood Hits	249	Shared Neighborhood Hits	17
SwissProt Accessions	Q8R4P4	Gene names	Tmc2
Domain Architecture	No domain graphic available
Description	Transmembrane cochlear-expressed protein 2.

UBP8_HUMAN
θ value	3.0926 (rank : 218)	NC score	0.015897 (rank : 315)
Query Neighborhood Hits	297	Target Neighborhood Hits	751	Shared Neighborhood Hits	61
SwissProt Accessions	P40818, Q7Z3U2, Q86VA0, Q8IWI7	Gene names	USP8, KIAA0055, UBPY
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (hUBPy).

ZIM10_HUMAN
θ value	3.0926 (rank : 219)	NC score	0.029385 (rank : 277)
Query Neighborhood Hits	297	Target Neighborhood Hits	577	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ULJ6, Q7Z7E6	Gene names	RAI17, KIAA1224, ZIMP10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

CCD16_MOUSE
θ value	4.03905 (rank : 220)	NC score	0.017705 (rank : 310)
Query Neighborhood Hits	297	Target Neighborhood Hits	218	Shared Neighborhood Hits	12
SwissProt Accessions	Q8R1N0, Q3TR52, Q9CWV9, Q9CYI6	Gene names	Ccdc16, Omcg1
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 16 (Ovus mutant candidate gene 1 protein).

CTGE6_HUMAN
θ value	4.03905 (rank : 221)	NC score	0.032200 (rank : 265)
Query Neighborhood Hits	297	Target Neighborhood Hits	650	Shared Neighborhood Hits	52
SwissProt Accessions	Q86UF2	Gene names	CTAGE6
Domain Architecture	No domain graphic available
Description	Protein cTAGE-6 (cTAGE family member 6).

FOSL1_HUMAN
θ value	4.03905 (rank : 222)	NC score	0.014338 (rank : 320)
Query Neighborhood Hits	297	Target Neighborhood Hits	112	Shared Neighborhood Hits	11
SwissProt Accessions	P15407	Gene names	FOSL1, FRA1
Domain Architecture
Description	Fos-related antigen 1 (FRA-1).

IDLC_MOUSE
θ value	4.03905 (rank : 223)	NC score	0.037311 (rank : 250)
Query Neighborhood Hits	297	Target Neighborhood Hits	321	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BVN8	Gene names	Dnali1
Domain Architecture	No domain graphic available
Description	Axonemal dynein light intermediate polypeptide 1 (Inner dynein arm light chain, axonemal).

LN28B_MOUSE
θ value	4.03905 (rank : 224)	NC score	0.011116 (rank : 330)
Query Neighborhood Hits	297	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	Q45KJ6, Q3UZC6, Q3V444	Gene names	Lin28b
Domain Architecture	No domain graphic available
Description	Lin-28 homolog B.

MYH7_HUMAN
θ value	4.03905 (rank : 225)	NC score	0.018544 (rank : 308)
Query Neighborhood Hits	297	Target Neighborhood Hits	1559	Shared Neighborhood Hits	65
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

NFAC1_HUMAN
θ value	4.03905 (rank : 226)	NC score	0.012564 (rank : 326)
Query Neighborhood Hits	297	Target Neighborhood Hits	312	Shared Neighborhood Hits	17
SwissProt Accessions	O95644, Q12865, Q15793	Gene names	NFATC1, NFAT2, NFATC
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcription complex cytosolic component) (NF-ATc1) (NF-ATc).

NPBL_MOUSE
θ value	4.03905 (rank : 227)	NC score	0.030549 (rank : 275)
Query Neighborhood Hits	297	Target Neighborhood Hits	1041	Shared Neighborhood Hits	60
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

PCLO_HUMAN
θ value	4.03905 (rank : 228)	NC score	0.040250 (rank : 238)
Query Neighborhood Hits	297	Target Neighborhood Hits	2046	Shared Neighborhood Hits	105
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PEPL_MOUSE
θ value	4.03905 (rank : 229)	NC score	0.031681 (rank : 267)
Query Neighborhood Hits	297	Target Neighborhood Hits	1105	Shared Neighborhood Hits	65
SwissProt Accessions	Q9R269, O70231, Q9CUT1, Q9JLZ7	Gene names	Ppl
Domain Architecture
Description	Periplakin.

PRR8_HUMAN
θ value	4.03905 (rank : 230)	NC score	0.029656 (rank : 276)
Query Neighborhood Hits	297	Target Neighborhood Hits	217	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NSV0	Gene names	PRR8
Domain Architecture	No domain graphic available
Description	Proline-rich protein 8.

PTN23_MOUSE
θ value	4.03905 (rank : 231)	NC score	0.049359 (rank : 229)
Query Neighborhood Hits	297	Target Neighborhood Hits	726	Shared Neighborhood Hits	55
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

RERE_HUMAN
θ value	4.03905 (rank : 232)	NC score	0.022280 (rank : 289)
Query Neighborhood Hits	297	Target Neighborhood Hits	779	Shared Neighborhood Hits	48
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

TB182_HUMAN
θ value	4.03905 (rank : 233)	NC score	0.026426 (rank : 283)
Query Neighborhood Hits	297	Target Neighborhood Hits	414	Shared Neighborhood Hits	31
SwissProt Accessions	Q9C0C2	Gene names	TNKS1BP1, KIAA1741, TAB182
Domain Architecture	No domain graphic available
Description	182 kDa tankyrase 1-binding protein.

TCAL3_HUMAN
θ value	4.03905 (rank : 234)	NC score	0.021910 (rank : 291)
Query Neighborhood Hits	297	Target Neighborhood Hits	274	Shared Neighborhood Hits	12
SwissProt Accessions	Q969E4	Gene names	TCEAL3
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 3 (TCEA-like protein 3) (Transcription elongation factor S-II protein-like 3).

ARI1A_HUMAN
θ value	5.27518 (rank : 235)	NC score	0.031081 (rank : 270)
Query Neighborhood Hits	297	Target Neighborhood Hits	787	Shared Neighborhood Hits	52
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

BPAEA_HUMAN
θ value	5.27518 (rank : 236)	NC score	0.019480 (rank : 301)
Query Neighborhood Hits	297	Target Neighborhood Hits	1369	Shared Neighborhood Hits	65
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

CO5A2_HUMAN
θ value	5.27518 (rank : 237)	NC score	0.022721 (rank : 288)
Query Neighborhood Hits	297	Target Neighborhood Hits	760	Shared Neighborhood Hits	47
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

GGA3_HUMAN
θ value	5.27518 (rank : 238)	NC score	0.007545 (rank : 339)
Query Neighborhood Hits	297	Target Neighborhood Hits	127	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NZ52, Q15017, Q6IS16, Q9UJY3	Gene names	GGA3, KIAA0154
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3).

IRX5_HUMAN
θ value	5.27518 (rank : 239)	NC score	0.011527 (rank : 329)
Query Neighborhood Hits	297	Target Neighborhood Hits	362	Shared Neighborhood Hits	15
SwissProt Accessions	P78411, P78416, Q7Z2E1	Gene names	IRX5, IRX2A, IRXB2
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-5 (Iroquois homeobox protein 5) (Homeodomain protein IRXB2) (IRX-2A).

LR37A_HUMAN
θ value	5.27518 (rank : 240)	NC score	0.013348 (rank : 324)
Query Neighborhood Hits	297	Target Neighborhood Hits	720	Shared Neighborhood Hits	29
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

LSD1_HUMAN
θ value	5.27518 (rank : 241)	NC score	0.013721 (rank : 322)
Query Neighborhood Hits	297	Target Neighborhood Hits	455	Shared Neighborhood Hits	30
SwissProt Accessions	O60341, Q5TH94, Q5TH95, Q86VT7, Q8IXK4, Q8NDP6, Q8TAZ3, Q96AW4	Gene names	AOF2, KIAA0601, LSD1
Domain Architecture	No domain graphic available
Description	Lysine-specific histone demethylase 1 (EC 1.-.-.-) (Flavin-containing amine oxidase domain-containing protein 2) (BRAF35-HDAC complex protein BHC110).

LTBP4_MOUSE
θ value	5.27518 (rank : 242)	NC score	-0.000829 (rank : 356)
Query Neighborhood Hits	297	Target Neighborhood Hits	607	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K4G1, Q8K4G0	Gene names	Ltbp4
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).

MPP6_HUMAN
θ value	5.27518 (rank : 243)	NC score	0.311468 (rank : 125)
Query Neighborhood Hits	297	Target Neighborhood Hits	180	Shared Neighborhood Hits	91
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
θ value	5.27518 (rank : 244)	NC score	0.319681 (rank : 124)
Query Neighborhood Hits	297	Target Neighborhood Hits	187	Shared Neighborhood Hits	96
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

PCD16_HUMAN
θ value	5.27518 (rank : 245)	NC score	-0.001054 (rank : 357)
Query Neighborhood Hits	297	Target Neighborhood Hits	245	Shared Neighborhood Hits	5
SwissProt Accessions	Q96JQ0, O15098	Gene names	DCHS1, CDH19, FIB1, KIAA1773, PCDH16
Domain Architecture
Description	Protocadherin-16 precursor (Dachsous 1) (Cadherin-19) (Fibroblast cadherin 1).

PCDA3_HUMAN
θ value	5.27518 (rank : 246)	NC score	-0.001560 (rank : 359)
Query Neighborhood Hits	297	Target Neighborhood Hits	203	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y5H8, O75286	Gene names	PCDHA3
Domain Architecture
Description	Protocadherin alpha 3 precursor (PCDH-alpha3).

PRP1_HUMAN
θ value	5.27518 (rank : 247)	NC score	0.032753 (rank : 263)
Query Neighborhood Hits	297	Target Neighborhood Hits	385	Shared Neighborhood Hits	30
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

RECQ5_HUMAN
θ value	5.27518 (rank : 248)	NC score	0.016073 (rank : 314)
Query Neighborhood Hits	297	Target Neighborhood Hits	390	Shared Neighborhood Hits	30
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

RFIP4_HUMAN
θ value	5.27518 (rank : 249)	NC score	0.034438 (rank : 257)
Query Neighborhood Hits	297	Target Neighborhood Hits	785	Shared Neighborhood Hits	53
SwissProt Accessions	Q86YS3, Q8N829, Q8NDT7, Q969D8	Gene names	RAB11FIP4, KIAA1821
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 4 (Rab11-FIP4).

TF3C1_MOUSE
θ value	5.27518 (rank : 250)	NC score	0.014812 (rank : 318)
Query Neighborhood Hits	297	Target Neighborhood Hits	92	Shared Neighborhood Hits	7
SwissProt Accessions	Q8K284, Q8CAL9	Gene names	Gtf3c1
Domain Architecture	No domain graphic available
Description	General transcription factor 3C polypeptide 1 (Transcription factor IIIC-subunit alpha) (TF3C-alpha) (TFIIIC 220 kDa subunit) (TFIIIC220) (TFIIIC box B-binding subunit).

APC_MOUSE
θ value	6.88961 (rank : 251)	NC score	0.019250 (rank : 303)
Query Neighborhood Hits	297	Target Neighborhood Hits	441	Shared Neighborhood Hits	40
SwissProt Accessions	Q61315, Q62044	Gene names	Apc
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC) (mAPC).

BRD4_MOUSE
θ value	6.88961 (rank : 252)	NC score	0.019848 (rank : 295)
Query Neighborhood Hits	297	Target Neighborhood Hits	845	Shared Neighborhood Hits	61
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

CD3Z_HUMAN
θ value	6.88961 (rank : 253)	NC score	0.010962 (rank : 331)
Query Neighborhood Hits	297	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	P20963, Q5VX13, Q8TAX4	Gene names	CD247, CD3Z, T3Z, TCRZ
Domain Architecture	No domain graphic available
Description	T-cell surface glycoprotein CD3 zeta chain precursor (T-cell receptor T3 zeta chain) (CD237 antigen).

CN155_HUMAN
θ value	6.88961 (rank : 254)	NC score	0.022010 (rank : 290)
Query Neighborhood Hits	297	Target Neighborhood Hits	385	Shared Neighborhood Hits	21
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

CO4A1_MOUSE
θ value	6.88961 (rank : 255)	NC score	0.019484 (rank : 300)
Query Neighborhood Hits	297	Target Neighborhood Hits	450	Shared Neighborhood Hits	30
SwissProt Accessions	P02463	Gene names	Col4a1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

DIDO1_HUMAN
θ value	6.88961 (rank : 256)	NC score	0.032801 (rank : 261)
Query Neighborhood Hits	297	Target Neighborhood Hits	960	Shared Neighborhood Hits	61
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

DJBP_MOUSE
θ value	6.88961 (rank : 257)	NC score	0.008243 (rank : 337)
Query Neighborhood Hits	297	Target Neighborhood Hits	152	Shared Neighborhood Hits	6
SwissProt Accessions	Q6P1E8, Q5DTV8, Q6PGK8, Q9D2D8	Gene names	Djbp, Kiaa1672
Domain Architecture	No domain graphic available
Description	DJ-1-binding protein.

HEM1_HUMAN
θ value	6.88961 (rank : 258)	NC score	0.006053 (rank : 341)
Query Neighborhood Hits	297	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	P13196	Gene names	ALAS1, ALASH
Domain Architecture
Description	5-aminolevulinate synthase, nonspecific, mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta-aminolevulinate synthase) (Delta-ALA synthetase) (ALAS-H).

HOOK3_HUMAN
θ value	6.88961 (rank : 259)	NC score	0.032153 (rank : 266)
Query Neighborhood Hits	297	Target Neighborhood Hits	1070	Shared Neighborhood Hits	67
SwissProt Accessions	Q86VS8, Q8NBH0, Q9BY13	Gene names	HOOK3
Domain Architecture
Description	Hook homolog 3 (hHK3).

IDLC_HUMAN
θ value	6.88961 (rank : 260)	NC score	0.027332 (rank : 281)
Query Neighborhood Hits	297	Target Neighborhood Hits	348	Shared Neighborhood Hits	31
SwissProt Accessions	O14645, Q5TGH0, Q7L0I5	Gene names	DNALI1
Domain Architecture	No domain graphic available
Description	Axonemal dynein light intermediate polypeptide 1 (Inner dynein arm light chain, axonemal) (hp28).

KLF17_HUMAN
θ value	6.88961 (rank : 261)	NC score	-0.006327 (rank : 363)
Query Neighborhood Hits	297	Target Neighborhood Hits	882	Shared Neighborhood Hits	18
SwissProt Accessions	Q5JT82, Q86VQ7, Q8N805	Gene names	KLF17, ZNF393
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 17 (Zinc finger protein 393).

LEG3_HUMAN
θ value	6.88961 (rank : 262)	NC score	0.011953 (rank : 328)
Query Neighborhood Hits	297	Target Neighborhood Hits	124	Shared Neighborhood Hits	15
SwissProt Accessions	P17931, Q16005, Q96J47	Gene names	LGALS3, MAC2
Domain Architecture
Description	Galectin-3 (Galactose-specific lectin 3) (Mac-2 antigen) (IgE-binding protein) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Laminin-binding protein) (Lectin L-29) (L-31) (Galactoside-binding protein) (GALBP).

LIPA3_MOUSE
θ value	6.88961 (rank : 263)	NC score	0.021037 (rank : 293)
Query Neighborhood Hits	297	Target Neighborhood Hits	636	Shared Neighborhood Hits	48
SwissProt Accessions	P60469	Gene names	Ppfia3
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

LRC56_HUMAN
θ value	6.88961 (rank : 264)	NC score	0.013376 (rank : 323)
Query Neighborhood Hits	297	Target Neighborhood Hits	165	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IYG6, Q8N3Q4	Gene names	LRRC56
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 56.

MYH3_HUMAN
θ value	6.88961 (rank : 265)	NC score	0.018911 (rank : 304)
Query Neighborhood Hits	297	Target Neighborhood Hits	1660	Shared Neighborhood Hits	72
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

PLS4_MOUSE
θ value	6.88961 (rank : 266)	NC score	0.007873 (rank : 338)
Query Neighborhood Hits	297	Target Neighborhood Hits	34	Shared Neighborhood Hits	5
SwissProt Accessions	P58196, Q3TMI2, Q8BH62	Gene names	Plscr4
Domain Architecture	No domain graphic available
Description	Phospholipid scramblase 4 (PL scramblase 4) (Ca(2+)-dependent phospholipid scramblase 4).

SDCB2_HUMAN
θ value	6.88961 (rank : 267)	NC score	0.269384 (rank : 138)
Query Neighborhood Hits	297	Target Neighborhood Hits	121	Shared Neighborhood Hits	95
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

TACC1_MOUSE
θ value	6.88961 (rank : 268)	NC score	0.022866 (rank : 287)
Query Neighborhood Hits	297	Target Neighborhood Hits	667	Shared Neighborhood Hits	46
SwissProt Accessions	Q6Y685, Q6Y686	Gene names	Tacc1
Domain Architecture	No domain graphic available
Description	Transforming acidic coiled-coil-containing protein 1.

TEX9_HUMAN
θ value	6.88961 (rank : 269)	NC score	0.023138 (rank : 286)
Query Neighborhood Hits	297	Target Neighborhood Hits	541	Shared Neighborhood Hits	45
SwissProt Accessions	Q8N6V9	Gene names	TEX9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein.

TOP2B_MOUSE
θ value	6.88961 (rank : 270)	NC score	0.009601 (rank : 336)
Query Neighborhood Hits	297	Target Neighborhood Hits	80	Shared Neighborhood Hits	7
SwissProt Accessions	Q64511, Q7TQG4	Gene names	Top2b
Domain Architecture
Description	DNA topoisomerase 2-beta (EC 5.99.1.3) (DNA topoisomerase II, beta isozyme).

TRI16_HUMAN
θ value	6.88961 (rank : 271)	NC score	0.004026 (rank : 350)
Query Neighborhood Hits	297	Target Neighborhood Hits	231	Shared Neighborhood Hits	10
SwissProt Accessions	O95361, Q7Z6I2, Q96BE8, Q96J43	Gene names	TRIM16, EBBP
Domain Architecture
Description	Tripartite motif-containing protein 16 (Estrogen-responsive B box protein).

ANX11_MOUSE
θ value	8.99809 (rank : 272)	NC score	0.004840 (rank : 345)
Query Neighborhood Hits	297	Target Neighborhood Hits	200	Shared Neighborhood Hits	15
SwissProt Accessions	P97384	Gene names	Anxa11, Anx11
Domain Architecture
Description	Annexin A11 (Annexin XI) (Calcyclin-associated annexin 50) (CAP-50).

ATS18_HUMAN
θ value	8.99809 (rank : 273)	NC score	-0.001307 (rank : 358)
Query Neighborhood Hits	297	Target Neighborhood Hits	169	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TE60, Q6P4R5, Q6ZWJ9	Gene names	ADAMTS18, ADAMTS21
Domain Architecture
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).

CCD21_MOUSE
θ value	8.99809 (rank : 274)	NC score	0.030674 (rank : 273)
Query Neighborhood Hits	297	Target Neighborhood Hits	1135	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CCD46_MOUSE
θ value	8.99809 (rank : 275)	NC score	0.028271 (rank : 280)
Query Neighborhood Hits	297	Target Neighborhood Hits	1405	Shared Neighborhood Hits	68
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

CI093_HUMAN
θ value	8.99809 (rank : 276)	NC score	0.029077 (rank : 278)
Query Neighborhood Hits	297	Target Neighborhood Hits	1088	Shared Neighborhood Hits	59
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

CJ012_HUMAN
θ value	8.99809 (rank : 277)	NC score	0.017180 (rank : 311)
Query Neighborhood Hits	297	Target Neighborhood Hits	467	Shared Neighborhood Hits	24
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

CO4A2_MOUSE
θ value	8.99809 (rank : 278)	NC score	0.018676 (rank : 307)
Query Neighborhood Hits	297	Target Neighborhood Hits	492	Shared Neighborhood Hits	37
SwissProt Accessions	P08122, Q61375	Gene names	Col4a2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

COIA1_HUMAN
θ value	8.99809 (rank : 279)	NC score	0.018855 (rank : 305)
Query Neighborhood Hits	297	Target Neighborhood Hits	447	Shared Neighborhood Hits	30
SwissProt Accessions	P39060, Q9UK38, Q9Y6Q7, Q9Y6Q8	Gene names	COL18A1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

EGR1_MOUSE
θ value	8.99809 (rank : 280)	NC score	-0.007302 (rank : 364)
Query Neighborhood Hits	297	Target Neighborhood Hits	816	Shared Neighborhood Hits	14
SwissProt Accessions	P08046, Q61777	Gene names	Egr1, Egr-1, Krox-24
Domain Architecture
Description	Early growth response protein 1 (EGR-1) (Krox-24 protein) (Transcription factor Zif268) (Nerve growth factor-induced protein A) (NGFI-A).

EHMT1_HUMAN
θ value	8.99809 (rank : 281)	NC score	0.000088 (rank : 354)
Query Neighborhood Hits	297	Target Neighborhood Hits	417	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H9B1, Q8TCN7, Q96F53, Q96JF1, Q96KH4	Gene names	EHMT1, EUHMTASE1, KIAA1876
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a- like protein 1) (GLP1).

GLE1_MOUSE
θ value	8.99809 (rank : 282)	NC score	0.019298 (rank : 302)
Query Neighborhood Hits	297	Target Neighborhood Hits	504	Shared Neighborhood Hits	38
SwissProt Accessions	Q8R322, Q3TT10, Q3TU23, Q3UD65, Q8BT16, Q9D4A6	Gene names	Gle1l
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein).

HRX_HUMAN
θ value	8.99809 (rank : 283)	NC score	0.010814 (rank : 332)
Query Neighborhood Hits	297	Target Neighborhood Hits	825	Shared Neighborhood Hits	36
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

IRS1_HUMAN
θ value	8.99809 (rank : 284)	NC score	0.005977 (rank : 342)
Query Neighborhood Hits	297	Target Neighborhood Hits	109	Shared Neighborhood Hits	6
SwissProt Accessions	P35568	Gene names	IRS1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

K1C12_MOUSE
θ value	8.99809 (rank : 285)	NC score	0.002312 (rank : 352)
Query Neighborhood Hits	297	Target Neighborhood Hits	409	Shared Neighborhood Hits	30
SwissProt Accessions	Q64291	Gene names	Krt12, Krt1-12, Krt1.12
Domain Architecture
Description	Keratin, type I cytoskeletal 12 (Cytokeratin-12) (CK-12) (Keratin-12) (K12).

LIMK1_HUMAN
θ value	8.99809 (rank : 286)	NC score	0.016817 (rank : 312)
Query Neighborhood Hits	297	Target Neighborhood Hits	1005	Shared Neighborhood Hits	66
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
θ value	8.99809 (rank : 287)	NC score	0.015450 (rank : 316)
Query Neighborhood Hits	297	Target Neighborhood Hits	1008	Shared Neighborhood Hits	66
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

M3K15_HUMAN
θ value	8.99809 (rank : 288)	NC score	-0.003536 (rank : 362)
Query Neighborhood Hits	297	Target Neighborhood Hits	914	Shared Neighborhood Hits	15
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

MLL3_HUMAN
θ value	8.99809 (rank : 289)	NC score	0.016379 (rank : 313)
Query Neighborhood Hits	297	Target Neighborhood Hits	1644	Shared Neighborhood Hits	73
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

MPP2_MOUSE
θ value	8.99809 (rank : 290)	NC score	0.310994 (rank : 126)
Query Neighborhood Hits	297	Target Neighborhood Hits	189	Shared Neighborhood Hits	95
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

MTFR1_MOUSE
θ value	8.99809 (rank : 291)	NC score	0.009699 (rank : 335)
Query Neighborhood Hits	297	Target Neighborhood Hits	38	Shared Neighborhood Hits	5
SwissProt Accessions	Q99MB2, Q9CQZ4	Gene names	Mtfr1, Kiaa0009
Domain Architecture	No domain graphic available
Description	Mitochondrial fission regulator 1.

NMDE1_HUMAN
θ value	8.99809 (rank : 292)	NC score	0.001280 (rank : 353)
Query Neighborhood Hits	297	Target Neighborhood Hits	81	Shared Neighborhood Hits	4
SwissProt Accessions	Q12879, O00669	Gene names	GRIN2A
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 1 precursor (N-methyl D- aspartate receptor subtype 2A) (NR2A) (NMDAR2A) (hNR2A).

PRR12_HUMAN
θ value	8.99809 (rank : 293)	NC score	0.020874 (rank : 294)
Query Neighborhood Hits	297	Target Neighborhood Hits	460	Shared Neighborhood Hits	26
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

RFFL_MOUSE
θ value	8.99809 (rank : 294)	NC score	0.005516 (rank : 343)
Query Neighborhood Hits	297	Target Neighborhood Hits	145	Shared Neighborhood Hits	5
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

TACC1_HUMAN
θ value	8.99809 (rank : 295)	NC score	0.025352 (rank : 284)
Query Neighborhood Hits	297	Target Neighborhood Hits	597	Shared Neighborhood Hits	45
SwissProt Accessions	O75410, Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2, Q8NEY7, Q9UPP9	Gene names	TACC1, KIAA1103
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 1 (Taxin 1) (Gastric cancer antigen Ga55).

TF65_MOUSE
θ value	8.99809 (rank : 296)	NC score	0.004571 (rank : 349)
Query Neighborhood Hits	297	Target Neighborhood Hits	66	Shared Neighborhood Hits	5
SwissProt Accessions	Q04207, Q62025	Gene names	Rela, Nfkb3
Domain Architecture
Description	Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit).

ZN236_HUMAN
θ value	8.99809 (rank : 297)	NC score	-0.008358 (rank : 365)
Query Neighborhood Hits	297	Target Neighborhood Hits	844	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UL36, Q9UL37	Gene names	ZNF236
Domain Architecture	No domain graphic available
Description	Zinc finger protein 236.

APXL_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.214004 (rank : 155)
Query Neighborhood Hits	297	Target Neighborhood Hits	553	Shared Neighborhood Hits	97
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

CACB1_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.054327 (rank : 211)
Query Neighborhood Hits	297	Target Neighborhood Hits	44	Shared Neighborhood Hits	20
SwissProt Accessions	Q02641, O15331, Q02639, Q02640, Q9C085	Gene names	CACNB1, CACNLB1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1).

CACB1_MOUSE
θ value	θ > 10 (rank : 300)	NC score	0.056952 (rank : 205)
Query Neighborhood Hits	297	Target Neighborhood Hits	46	Shared Neighborhood Hits	19
SwissProt Accessions	Q8R3Z5, O88517, Q7TPF2, Q8R3Z6, Q9EPT9	Gene names	Cacnb1, Cacnlb1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1).

CACB3_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.054914 (rank : 209)
Query Neighborhood Hits	297	Target Neighborhood Hits	45	Shared Neighborhood Hits	17
SwissProt Accessions	P54284, Q13913	Gene names	CACNB3, CACNLB3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3).

CACB3_MOUSE
θ value	θ > 10 (rank : 302)	NC score	0.054850 (rank : 210)
Query Neighborhood Hits	297	Target Neighborhood Hits	48	Shared Neighborhood Hits	18
SwissProt Accessions	P54285	Gene names	Cacnb3, Cacnlb3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3) (CCHB3).

CACB4_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.053740 (rank : 214)
Query Neighborhood Hits	297	Target Neighborhood Hits	47	Shared Neighborhood Hits	18
SwissProt Accessions	O00305, O60515, Q96L40	Gene names	CACNB4, CACNLB4
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4).

CACB4_MOUSE
θ value	θ > 10 (rank : 304)	NC score	0.052095 (rank : 218)
Query Neighborhood Hits	297	Target Neighborhood Hits	42	Shared Neighborhood Hits	17
SwissProt Accessions	Q8R0S4, Q8BRN6, Q8CAJ9	Gene names	Cacnb4, Cacnlb4
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4).

CAR11_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.085196 (rank : 194)
Query Neighborhood Hits	297	Target Neighborhood Hits	690	Shared Neighborhood Hits	76
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

CAR14_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.063683 (rank : 202)
Query Neighborhood Hits	297	Target Neighborhood Hits	449	Shared Neighborhood Hits	67
SwissProt Accessions	Q9BXL6, Q9BVB5	Gene names	CARD14, CARMA2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2).

CAR14_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.053061 (rank : 216)
Query Neighborhood Hits	297	Target Neighborhood Hits	526	Shared Neighborhood Hits	59
SwissProt Accessions	Q99KF0	Gene names	Card14, Bimp2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (Bcl10-interacting MAGUK protein 2) (Bimp2).

CNKR2_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.099060 (rank : 185)
Query Neighborhood Hits	297	Target Neighborhood Hits	197	Shared Neighborhood Hits	49
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.099000 (rank : 186)
Query Neighborhood Hits	297	Target Neighborhood Hits	197	Shared Neighborhood Hits	48
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CRK_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.050543 (rank : 223)
Query Neighborhood Hits	297	Target Neighborhood Hits	308	Shared Neighborhood Hits	24
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.050115 (rank : 226)
Query Neighborhood Hits	297	Target Neighborhood Hits	314	Shared Neighborhood Hits	25
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

FRMD1_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.052549 (rank : 217)
Query Neighborhood Hits	297	Target Neighborhood Hits	48	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N878, Q5SZU7, Q9UFB0	Gene names	FRMD1
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 1.

GIPC2_HUMAN
θ value	θ > 10 (rank : 313)	NC score	0.182449 (rank : 160)
Query Neighborhood Hits	297	Target Neighborhood Hits	93	Shared Neighborhood Hits	83
SwissProt Accessions	Q8TF65, Q8IYD3, Q9NXS7	Gene names	GIPC2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2.

GIPC2_MOUSE
θ value	θ > 10 (rank : 314)	NC score	0.111757 (rank : 180)
Query Neighborhood Hits	297	Target Neighborhood Hits	71	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Z2H7, Q9CVG2	Gene names	Gipc2, Semcap2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2 (SemaF cytoplasmic domain- associated protein 2) (SEMCAP-2).

GIPC3_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.113013 (rank : 179)
Query Neighborhood Hits	297	Target Neighborhood Hits	52	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TF64, O75227	Gene names	GIPC3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3.

GIPC3_MOUSE
θ value	θ > 10 (rank : 316)	NC score	0.108761 (rank : 182)
Query Neighborhood Hits	297	Target Neighborhood Hits	53	Shared Neighborhood Hits	44
SwissProt Accessions	Q8R5M0	Gene names	Gipc3, Rgs19ip3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3 (Regulator of G-protein signaling 19-interacting protein 3).

GRASP_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.290925 (rank : 133)
Query Neighborhood Hits	297	Target Neighborhood Hits	147	Shared Neighborhood Hits	92
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

GRASP_MOUSE
θ value	θ > 10 (rank : 318)	NC score	0.286342 (rank : 134)
Query Neighborhood Hits	297	Target Neighborhood Hits	131	Shared Neighborhood Hits	90
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

HTRA3_HUMAN
θ value	θ > 10 (rank : 319)	NC score	0.067943 (rank : 200)
Query Neighborhood Hits	297	Target Neighborhood Hits	152	Shared Neighborhood Hits	59
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

HTRA3_MOUSE
θ value	θ > 10 (rank : 320)	NC score	0.073127 (rank : 198)
Query Neighborhood Hits	297	Target Neighborhood Hits	156	Shared Neighborhood Hits	63
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

KGUA_HUMAN
θ value	θ > 10 (rank : 321)	NC score	0.240401 (rank : 144)
Query Neighborhood Hits	297	Target Neighborhood Hits	41	Shared Neighborhood Hits	26
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KGUA_MOUSE
θ value	θ > 10 (rank : 322)	NC score	0.241641 (rank : 143)
Query Neighborhood Hits	297	Target Neighborhood Hits	45	Shared Neighborhood Hits	26
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

LDB3_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.134662 (rank : 174)
Query Neighborhood Hits	297	Target Neighborhood Hits	497	Shared Neighborhood Hits	92
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

LDB3_MOUSE
θ value	θ > 10 (rank : 324)	NC score	0.135633 (rank : 173)
Query Neighborhood Hits	297	Target Neighborhood Hits	510	Shared Neighborhood Hits	88
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

LMO7_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.106761 (rank : 184)
Query Neighborhood Hits	297	Target Neighborhood Hits	507	Shared Neighborhood Hits	77
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

LRRC1_HUMAN
θ value	θ > 10 (rank : 326)	NC score	0.050952 (rank : 222)
Query Neighborhood Hits	297	Target Neighborhood Hits	282	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BTT6, Q9HAC0, Q9NVF1	Gene names	LRRC1, LANO
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 1 (LAP and no PDZ protein) (LANO adapter protein).

LRRC1_MOUSE
θ value	θ > 10 (rank : 327)	NC score	0.051381 (rank : 220)
Query Neighborhood Hits	297	Target Neighborhood Hits	281	Shared Neighborhood Hits	8
SwissProt Accessions	Q80VQ1, Q3UI50, Q8BKR1, Q8BUS9	Gene names	Lrrc1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 1.

MPP2_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.305176 (rank : 130)
Query Neighborhood Hits	297	Target Neighborhood Hits	173	Shared Neighborhood Hits	91
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

PDLI1_HUMAN
θ value	θ > 10 (rank : 329)	NC score	0.148918 (rank : 168)
Query Neighborhood Hits	297	Target Neighborhood Hits	242	Shared Neighborhood Hits	73
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PDLI1_MOUSE
θ value	θ > 10 (rank : 330)	NC score	0.156076 (rank : 166)
Query Neighborhood Hits	297	Target Neighborhood Hits	213	Shared Neighborhood Hits	74
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PDLI2_MOUSE
θ value	θ > 10 (rank : 331)	NC score	0.258312 (rank : 140)
Query Neighborhood Hits	297	Target Neighborhood Hits	220	Shared Neighborhood Hits	91
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

PDLI3_HUMAN
θ value	θ > 10 (rank : 332)	NC score	0.172160 (rank : 161)
Query Neighborhood Hits	297	Target Neighborhood Hits	199	Shared Neighborhood Hits	82
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PDLI3_MOUSE
θ value	θ > 10 (rank : 333)	NC score	0.151871 (rank : 167)
Query Neighborhood Hits	297	Target Neighborhood Hits	197	Shared Neighborhood Hits	78
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PDLI4_HUMAN
θ value	θ > 10 (rank : 334)	NC score	0.162043 (rank : 164)
Query Neighborhood Hits	297	Target Neighborhood Hits	245	Shared Neighborhood Hits	81
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PDLI4_MOUSE
θ value	θ > 10 (rank : 335)	NC score	0.161192 (rank : 165)
Query Neighborhood Hits	297	Target Neighborhood Hits	233	Shared Neighborhood Hits	81
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PDLI5_HUMAN
θ value	θ > 10 (rank : 336)	NC score	0.133421 (rank : 175)
Query Neighborhood Hits	297	Target Neighborhood Hits	322	Shared Neighborhood Hits	90
SwissProt Accessions	Q96HC4, O60705	Gene names	PDLIM5, ENH
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PDLI5_MOUSE
θ value	θ > 10 (rank : 337)	NC score	0.137724 (rank : 171)
Query Neighborhood Hits	297	Target Neighborhood Hits	287	Shared Neighborhood Hits	86
SwissProt Accessions	Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2	Gene names	Pdlim5, Enh
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PDLI7_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.121626 (rank : 178)
Query Neighborhood Hits	297	Target Neighborhood Hits	547	Shared Neighborhood Hits	100
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PDLI7_MOUSE
θ value	θ > 10 (rank : 339)	NC score	0.111557 (rank : 181)
Query Neighborhood Hits	297	Target Neighborhood Hits	279	Shared Neighborhood Hits	73
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PDZD8_HUMAN
θ value	θ > 10 (rank : 340)	NC score	0.108355 (rank : 183)
Query Neighborhood Hits	297	Target Neighborhood Hits	185	Shared Neighborhood Hits	41
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PRAX_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.070428 (rank : 199)
Query Neighborhood Hits	297	Target Neighborhood Hits	215	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BXM0, Q9BXL9, Q9HCF2	Gene names	PRX, KIAA1620
Domain Architecture
Description	Periaxin.

PRAX_MOUSE
θ value	θ > 10 (rank : 342)	NC score	0.089894 (rank : 189)
Query Neighborhood Hits	297	Target Neighborhood Hits	199	Shared Neighborhood Hits	50
SwissProt Accessions	O55103, O55104	Gene names	Prx
Domain Architecture
Description	Periaxin.

PSCBP_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.251824 (rank : 142)
Query Neighborhood Hits	297	Target Neighborhood Hits	123	Shared Neighborhood Hits	89
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

PSCBP_MOUSE
θ value	θ > 10 (rank : 344)	NC score	0.273189 (rank : 137)
Query Neighborhood Hits	297	Target Neighborhood Hits	118	Shared Neighborhood Hits	86
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

PSMD9_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.054988 (rank : 207)
Query Neighborhood Hits	297	Target Neighborhood Hits	36	Shared Neighborhood Hits	17
SwissProt Accessions	O00233, Q9BQ42	Gene names	PSMD9
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27).

RAIN_HUMAN
θ value	θ > 10 (rank : 346)	NC score	0.054916 (rank : 208)
Query Neighborhood Hits	297	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	Q5U651, Q6U676	Gene names	RASIP1
Domain Architecture	No domain graphic available
Description	Ras-interacting protein 1 (Rain).

RAIN_MOUSE
θ value	θ > 10 (rank : 347)	NC score	0.053784 (rank : 213)
Query Neighborhood Hits	297	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q3U0S6, Q6GQW4	Gene names	Rasip1
Domain Architecture	No domain graphic available
Description	Ras-interacting protein 1 (Rain).

RGS12_HUMAN
θ value	θ > 10 (rank : 348)	NC score	0.255802 (rank : 141)
Query Neighborhood Hits	297	Target Neighborhood Hits	333	Shared Neighborhood Hits	114
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

RHPN2_MOUSE
θ value	θ > 10 (rank : 349)	NC score	0.084238 (rank : 195)
Query Neighborhood Hits	297	Target Neighborhood Hits	60	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BWR8, Q9DBN2	Gene names	Rhpn2
Domain Architecture	No domain graphic available
Description	Rhophilin-2 (GTP-Rho-binding protein 2).

RNF41_HUMAN
θ value	θ > 10 (rank : 350)	NC score	0.087918 (rank : 191)
Query Neighborhood Hits	297	Target Neighborhood Hits	226	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H4P4, O75598	Gene names	RNF41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

RNF41_MOUSE
θ value	θ > 10 (rank : 351)	NC score	0.088164 (rank : 190)
Query Neighborhood Hits	297	Target Neighborhood Hits	224	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BH75, Q8BGJ2, Q8BMC9, Q8VEA2, Q9CRK6, Q9D568	Gene names	Rnf41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

SAV1_HUMAN
θ value	θ > 10 (rank : 352)	NC score	0.058495 (rank : 204)
Query Neighborhood Hits	297	Target Neighborhood Hits	51	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
θ value	θ > 10 (rank : 353)	NC score	0.058569 (rank : 203)
Query Neighborhood Hits	297	Target Neighborhood Hits	48	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

SDCB2_MOUSE
θ value	θ > 10 (rank : 354)	NC score	0.277069 (rank : 136)
Query Neighborhood Hits	297	Target Neighborhood Hits	118	Shared Neighborhood Hits	100
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

SHAN2_HUMAN
θ value	θ > 10 (rank : 355)	NC score	0.239109 (rank : 145)
Query Neighborhood Hits	297	Target Neighborhood Hits	346	Shared Neighborhood Hits	100
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

SHAN2_MOUSE
θ value	θ > 10 (rank : 356)	NC score	0.214593 (rank : 154)
Query Neighborhood Hits	297	Target Neighborhood Hits	446	Shared Neighborhood Hits	98
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SYNP2_HUMAN
θ value	θ > 10 (rank : 357)	NC score	0.148627 (rank : 169)
Query Neighborhood Hits	297	Target Neighborhood Hits	323	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

SYNP2_MOUSE
θ value	θ > 10 (rank : 358)	NC score	0.204114 (rank : 158)
Query Neighborhood Hits	297	Target Neighborhood Hits	252	Shared Neighborhood Hits	93
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

SYP2L_HUMAN
θ value	θ > 10 (rank : 359)	NC score	0.236020 (rank : 146)
Query Neighborhood Hits	297	Target Neighborhood Hits	400	Shared Neighborhood Hits	93
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

SYP2L_MOUSE
θ value	θ > 10 (rank : 360)	NC score	0.166315 (rank : 163)
Query Neighborhood Hits	297	Target Neighborhood Hits	289	Shared Neighborhood Hits	77
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

TIAM1_HUMAN
θ value	θ > 10 (rank : 361)	NC score	0.074658 (rank : 196)
Query Neighborhood Hits	297	Target Neighborhood Hits	225	Shared Neighborhood Hits	62
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 362)	NC score	0.050340 (rank : 224)
Query Neighborhood Hits	297	Target Neighborhood Hits	205	Shared Neighborhood Hits	44
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

WWC1_HUMAN
θ value	θ > 10 (rank : 363)	NC score	0.056261 (rank : 206)
Query Neighborhood Hits	297	Target Neighborhood Hits	290	Shared Neighborhood Hits	29
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
θ value	θ > 10 (rank : 364)	NC score	0.053739 (rank : 215)
Query Neighborhood Hits	297	Target Neighborhood Hits	290	Shared Neighborhood Hits	22
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

YAP1_MOUSE
θ value	θ > 10 (rank : 365)	NC score	0.050204 (rank : 225)
Query Neighborhood Hits	297	Target Neighborhood Hits	96	Shared Neighborhood Hits	11
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

Hits sorted by NC score

PAR3L_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	297	Target Neighborhood Hits	297	Shared Neighborhood Hits	297
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

PARD3_MOUSE
NC score	0.936136 (rank : 2)	θ value	5.41814e-138 (rank : 2)
Query Neighborhood Hits	297	Target Neighborhood Hits	290	Shared Neighborhood Hits	154
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

PARD3_HUMAN
NC score	0.932436 (rank : 3)	θ value	1.93603e-119 (rank : 3)
Query Neighborhood Hits	297	Target Neighborhood Hits	312	Shared Neighborhood Hits	157
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

MPDZ_HUMAN
NC score	0.806879 (rank : 4)	θ value	4.43474e-23 (rank : 4)
Query Neighborhood Hits	297	Target Neighborhood Hits	261	Shared Neighborhood Hits	156
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

INADL_HUMAN
NC score	0.804964 (rank : 5)	θ value	1.09232e-21 (rank : 5)
Query Neighborhood Hits	297	Target Neighborhood Hits	260	Shared Neighborhood Hits	156
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

MPDZ_MOUSE
NC score	0.804569 (rank : 6)	θ value	5.42112e-21 (rank : 7)
Query Neighborhood Hits	297	Target Neighborhood Hits	298	Shared Neighborhood Hits	157
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

INADL_MOUSE
NC score	0.802289 (rank : 7)	θ value	3.17815e-21 (rank : 6)
Query Neighborhood Hits	297	Target Neighborhood Hits	290	Shared Neighborhood Hits	157
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

SYJ2B_HUMAN
NC score	0.775886 (rank : 8)	θ value	6.21693e-09 (rank : 34)
Query Neighborhood Hits	297	Target Neighborhood Hits	162	Shared Neighborhood Hits	134
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

LNX2_MOUSE
NC score	0.727321 (rank : 9)	θ value	6.85773e-16 (rank : 10)
Query Neighborhood Hits	297	Target Neighborhood Hits	407	Shared Neighborhood Hits	150
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

LNX2_HUMAN
NC score	0.721116 (rank : 10)	θ value	1.16975e-15 (rank : 14)
Query Neighborhood Hits	297	Target Neighborhood Hits	389	Shared Neighborhood Hits	148
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

LNX1_MOUSE
NC score	0.716359 (rank : 11)	θ value	9.90251e-15 (rank : 19)
Query Neighborhood Hits	297	Target Neighborhood Hits	377	Shared Neighborhood Hits	149
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

DLG4_MOUSE
NC score	0.716283 (rank : 12)	θ value	8.95645e-16 (rank : 12)
Query Neighborhood Hits	297	Target Neighborhood Hits	282	Shared Neighborhood Hits	153
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_HUMAN
NC score	0.715296 (rank : 13)	θ value	1.52774e-15 (rank : 16)
Query Neighborhood Hits	297	Target Neighborhood Hits	286	Shared Neighborhood Hits	153
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

IL16_HUMAN
NC score	0.712715 (rank : 14)	θ value	2.69671e-12 (rank : 25)
Query Neighborhood Hits	297	Target Neighborhood Hits	207	Shared Neighborhood Hits	132
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

LNX1_HUMAN
NC score	0.711871 (rank : 15)	θ value	7.58209e-15 (rank : 18)
Query Neighborhood Hits	297	Target Neighborhood Hits	379	Shared Neighborhood Hits	138
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

LIN7B_HUMAN
NC score	0.708892 (rank : 16)	θ value	5.81887e-07 (rank : 54)
Query Neighborhood Hits	297	Target Neighborhood Hits	200	Shared Neighborhood Hits	151
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

LIN7B_MOUSE
NC score	0.708564 (rank : 17)	θ value	5.81887e-07 (rank : 55)
Query Neighborhood Hits	297	Target Neighborhood Hits	200	Shared Neighborhood Hits	151
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

USH1C_HUMAN
NC score	0.706682 (rank : 18)	θ value	2.36244e-08 (rank : 40)
Query Neighborhood Hits	297	Target Neighborhood Hits	327	Shared Neighborhood Hits	164
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

LIN7C_HUMAN
NC score	0.706336 (rank : 19)	θ value	2.88788e-06 (rank : 67)
Query Neighborhood Hits	297	Target Neighborhood Hits	198	Shared Neighborhood Hits	151
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
NC score	0.706336 (rank : 20)	θ value	2.88788e-06 (rank : 68)
Query Neighborhood Hits	297	Target Neighborhood Hits	198	Shared Neighborhood Hits	151
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

DLG3_MOUSE
NC score	0.706130 (rank : 21)	θ value	6.85773e-16 (rank : 9)
Query Neighborhood Hits	297	Target Neighborhood Hits	274	Shared Neighborhood Hits	155
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

PDZD2_HUMAN
NC score	0.705475 (rank : 22)	θ value	5.43371e-13 (rank : 24)
Query Neighborhood Hits	297	Target Neighborhood Hits	772	Shared Neighborhood Hits	176
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

DLG1_MOUSE
NC score	0.704957 (rank : 23)	θ value	1.52774e-15 (rank : 15)
Query Neighborhood Hits	297	Target Neighborhood Hits	285	Shared Neighborhood Hits	153
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

LIN7A_MOUSE
NC score	0.704893 (rank : 24)	θ value	5.81887e-07 (rank : 53)
Query Neighborhood Hits	297	Target Neighborhood Hits	193	Shared Neighborhood Hits	150
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

LIN7A_HUMAN
NC score	0.704752 (rank : 25)	θ value	5.81887e-07 (rank : 52)
Query Neighborhood Hits	297	Target Neighborhood Hits	193	Shared Neighborhood Hits	150
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

DLG1_HUMAN
NC score	0.704440 (rank : 26)	θ value	6.85773e-16 (rank : 8)
Query Neighborhood Hits	297	Target Neighborhood Hits	290	Shared Neighborhood Hits	155
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

DLG3_HUMAN
NC score	0.702286 (rank : 27)	θ value	1.16975e-15 (rank : 13)
Query Neighborhood Hits	297	Target Neighborhood Hits	269	Shared Neighborhood Hits	155
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG2_MOUSE
NC score	0.699762 (rank : 28)	θ value	1.68911e-14 (rank : 20)
Query Neighborhood Hits	297	Target Neighborhood Hits	271	Shared Neighborhood Hits	153
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG2_HUMAN
NC score	0.698477 (rank : 29)	θ value	3.76295e-14 (rank : 21)
Query Neighborhood Hits	297	Target Neighborhood Hits	279	Shared Neighborhood Hits	154
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

PDZD7_HUMAN
NC score	0.697463 (rank : 30)	θ value	6.87365e-08 (rank : 43)
Query Neighborhood Hits	297	Target Neighborhood Hits	181	Shared Neighborhood Hits	138
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

IL16_MOUSE
NC score	0.680712 (rank : 31)	θ value	2.79066e-09 (rank : 30)
Query Neighborhood Hits	297	Target Neighborhood Hits	189	Shared Neighborhood Hits	131
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

GRIP2_HUMAN
NC score	0.675863 (rank : 32)	θ value	5.81887e-07 (rank : 51)
Query Neighborhood Hits	297	Target Neighborhood Hits	256	Shared Neighborhood Hits	155
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

WHRN_HUMAN
NC score	0.670370 (rank : 33)	θ value	1.80886e-08 (rank : 37)
Query Neighborhood Hits	297	Target Neighborhood Hits	325	Shared Neighborhood Hits	157
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

WHRN_MOUSE
NC score	0.666972 (rank : 34)	θ value	1.80886e-08 (rank : 38)
Query Neighborhood Hits	297	Target Neighborhood Hits	412	Shared Neighborhood Hits	159
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

GRIP1_HUMAN
NC score	0.666634 (rank : 35)	θ value	2.61198e-07 (rank : 48)
Query Neighborhood Hits	297	Target Neighborhood Hits	231	Shared Neighborhood Hits	154
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

GRIP1_MOUSE
NC score	0.663730 (rank : 36)	θ value	2.61198e-07 (rank : 49)
Query Neighborhood Hits	297	Target Neighborhood Hits	241	Shared Neighborhood Hits	154
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

USH1C_MOUSE
NC score	0.660826 (rank : 37)	θ value	1.99992e-07 (rank : 47)
Query Neighborhood Hits	297	Target Neighborhood Hits	557	Shared Neighborhood Hits	182
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

PDZD1_MOUSE
NC score	0.653715 (rank : 38)	θ value	2.79066e-09 (rank : 31)
Query Neighborhood Hits	297	Target Neighborhood Hits	191	Shared Neighborhood Hits	127
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

MAGI1_MOUSE
NC score	0.653529 (rank : 39)	θ value	3.89403e-11 (rank : 26)
Query Neighborhood Hits	297	Target Neighborhood Hits	403	Shared Neighborhood Hits	164
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

PDZD1_HUMAN
NC score	0.647620 (rank : 40)	θ value	3.29651e-10 (rank : 29)
Query Neighborhood Hits	297	Target Neighborhood Hits	190	Shared Neighborhood Hits	125
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

MAGI1_HUMAN
NC score	0.643939 (rank : 41)	θ value	2.36244e-08 (rank : 39)
Query Neighborhood Hits	297	Target Neighborhood Hits	388	Shared Neighborhood Hits	161
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI2_MOUSE
NC score	0.631560 (rank : 42)	θ value	1.133e-10 (rank : 27)
Query Neighborhood Hits	297	Target Neighborhood Hits	370	Shared Neighborhood Hits	166
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

MAGI2_HUMAN
NC score	0.628727 (rank : 43)	θ value	1.9326e-10 (rank : 28)
Query Neighborhood Hits	297	Target Neighborhood Hits	373	Shared Neighborhood Hits	160
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

NHERF_MOUSE
NC score	0.624403 (rank : 44)	θ value	1.53129e-07 (rank : 46)
Query Neighborhood Hits	297	Target Neighborhood Hits	195	Shared Neighborhood Hits	127
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHRF2_HUMAN
NC score	0.620461 (rank : 45)	θ value	5.26297e-08 (rank : 41)
Query Neighborhood Hits	297	Target Neighborhood Hits	197	Shared Neighborhood Hits	134
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

NHRF2_MOUSE
NC score	0.608173 (rank : 46)	θ value	9.92553e-07 (rank : 62)
Query Neighborhood Hits	297	Target Neighborhood Hits	194	Shared Neighborhood Hits	135
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

NHERF_HUMAN
NC score	0.602835 (rank : 47)	θ value	8.40245e-06 (rank : 72)
Query Neighborhood Hits	297	Target Neighborhood Hits	190	Shared Neighborhood Hits	126
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

PDZD3_HUMAN
NC score	0.597249 (rank : 48)	θ value	1.43324e-05 (rank : 73)
Query Neighborhood Hits	297	Target Neighborhood Hits	180	Shared Neighborhood Hits	128
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

PZRN3_MOUSE
NC score	0.590329 (rank : 49)	θ value	1.06045e-08 (rank : 36)
Query Neighborhood Hits	297	Target Neighborhood Hits	447	Shared Neighborhood Hits	139
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PZRN4_HUMAN
NC score	0.589780 (rank : 50)	θ value	6.87365e-08 (rank : 44)
Query Neighborhood Hits	297	Target Neighborhood Hits	438	Shared Neighborhood Hits	141
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

PZRN3_HUMAN
NC score	0.586049 (rank : 51)	θ value	5.26297e-08 (rank : 42)
Query Neighborhood Hits	297	Target Neighborhood Hits	461	Shared Neighborhood Hits	145
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

GOPC_MOUSE
NC score	0.579774 (rank : 52)	θ value	0.0431538 (rank : 131)
Query Neighborhood Hits	297	Target Neighborhood Hits	323	Shared Neighborhood Hits	150
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

PDZ11_HUMAN
NC score	0.575776 (rank : 53)	θ value	0.0193708 (rank : 119)
Query Neighborhood Hits	297	Target Neighborhood Hits	160	Shared Neighborhood Hits	117
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZD3_MOUSE
NC score	0.574955 (rank : 54)	θ value	1.29631e-06 (rank : 63)
Query Neighborhood Hits	297	Target Neighborhood Hits	171	Shared Neighborhood Hits	125
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

PDZ11_MOUSE
NC score	0.571240 (rank : 55)	θ value	0.0563607 (rank : 135)
Query Neighborhood Hits	297	Target Neighborhood Hits	154	Shared Neighborhood Hits	112
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

GOPC_HUMAN
NC score	0.570816 (rank : 56)	θ value	0.0431538 (rank : 130)
Query Neighborhood Hits	297	Target Neighborhood Hits	377	Shared Neighborhood Hits	155
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

K1849_HUMAN
NC score	0.567069 (rank : 57)	θ value	9.92553e-07 (rank : 60)
Query Neighborhood Hits	297	Target Neighborhood Hits	220	Shared Neighborhood Hits	132
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

SNTG2_HUMAN
NC score	0.563788 (rank : 58)	θ value	0.00035302 (rank : 83)
Query Neighborhood Hits	297	Target Neighborhood Hits	191	Shared Neighborhood Hits	147
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

TX1B3_HUMAN
NC score	0.558477 (rank : 59)	θ value	1.38821 (rank : 188)
Query Neighborhood Hits	297	Target Neighborhood Hits	161	Shared Neighborhood Hits	129
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

ZO3_MOUSE
NC score	0.553425 (rank : 60)	θ value	0.00509761 (rank : 107)
Query Neighborhood Hits	297	Target Neighborhood Hits	224	Shared Neighborhood Hits	148
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

TX1B3_MOUSE
NC score	0.553374 (rank : 61)	θ value	1.38821 (rank : 189)
Query Neighborhood Hits	297	Target Neighborhood Hits	158	Shared Neighborhood Hits	126
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

K1849_MOUSE
NC score	0.549158 (rank : 62)	θ value	9.92553e-07 (rank : 61)
Query Neighborhood Hits	297	Target Neighborhood Hits	335	Shared Neighborhood Hits	148
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

ZO3_HUMAN
NC score	0.546935 (rank : 63)	θ value	0.0330416 (rank : 127)
Query Neighborhood Hits	297	Target Neighborhood Hits	219	Shared Neighborhood Hits	143
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

SNTB2_MOUSE
NC score	0.540485 (rank : 64)	θ value	0.00175202 (rank : 93)
Query Neighborhood Hits	297	Target Neighborhood Hits	181	Shared Neighborhood Hits	138
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

SNTB2_HUMAN
NC score	0.540471 (rank : 65)	θ value	0.000602161 (rank : 87)
Query Neighborhood Hits	297	Target Neighborhood Hits	180	Shared Neighborhood Hits	139
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

ZO1_MOUSE
NC score	0.530881 (rank : 66)	θ value	3.77169e-06 (rank : 69)
Query Neighborhood Hits	297	Target Neighborhood Hits	453	Shared Neighborhood Hits	152
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

SNTA1_HUMAN
NC score	0.528686 (rank : 67)	θ value	0.000602161 (rank : 86)
Query Neighborhood Hits	297	Target Neighborhood Hits	186	Shared Neighborhood Hits	137
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

SNTG2_MOUSE
NC score	0.526983 (rank : 68)	θ value	0.00228821 (rank : 98)
Query Neighborhood Hits	297	Target Neighborhood Hits	176	Shared Neighborhood Hits	136
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SNTA1_MOUSE
NC score	0.525364 (rank : 69)	θ value	0.000270298 (rank : 82)
Query Neighborhood Hits	297	Target Neighborhood Hits	170	Shared Neighborhood Hits	130
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

AFAD_HUMAN
NC score	0.524657 (rank : 70)	θ value	1.17247e-07 (rank : 45)
Query Neighborhood Hits	297	Target Neighborhood Hits	689	Shared Neighborhood Hits	167
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

ZO1_HUMAN
NC score	0.521906 (rank : 71)	θ value	0.000786445 (rank : 88)
Query Neighborhood Hits	297	Target Neighborhood Hits	474	Shared Neighborhood Hits	155
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZO2_MOUSE
NC score	0.517537 (rank : 72)	θ value	0.00175202 (rank : 95)
Query Neighborhood Hits	297	Target Neighborhood Hits	296	Shared Neighborhood Hits	147
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZO2_HUMAN
NC score	0.515651 (rank : 73)	θ value	0.00175202 (rank : 94)
Query Neighborhood Hits	297	Target Neighborhood Hits	289	Shared Neighborhood Hits	148
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

DVL1_HUMAN
NC score	0.512625 (rank : 74)	θ value	7.59969e-07 (rank : 58)
Query Neighborhood Hits	297	Target Neighborhood Hits	158	Shared Neighborhood Hits	121
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL1_MOUSE
NC score	0.511561 (rank : 75)	θ value	3.41135e-07 (rank : 50)
Query Neighborhood Hits	297	Target Neighborhood Hits	146	Shared Neighborhood Hits	118
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL3_MOUSE
NC score	0.510280 (rank : 76)	θ value	4.1701e-05 (rank : 75)
Query Neighborhood Hits	297	Target Neighborhood Hits	198	Shared Neighborhood Hits	114
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_HUMAN
NC score	0.509095 (rank : 77)	θ value	4.1701e-05 (rank : 74)
Query Neighborhood Hits	297	Target Neighborhood Hits	194	Shared Neighborhood Hits	115
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

SNTG1_HUMAN
NC score	0.508207 (rank : 78)	θ value	0.0148317 (rank : 117)
Query Neighborhood Hits	297	Target Neighborhood Hits	181	Shared Neighborhood Hits	138
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTG1_MOUSE
NC score	0.506911 (rank : 79)	θ value	0.0148317 (rank : 118)
Query Neighborhood Hits	297	Target Neighborhood Hits	179	Shared Neighborhood Hits	137
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTB1_HUMAN
NC score	0.505199 (rank : 80)	θ value	0.00298849 (rank : 102)
Query Neighborhood Hits	297	Target Neighborhood Hits	157	Shared Neighborhood Hits	127
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

SNTB1_MOUSE
NC score	0.503998 (rank : 81)	θ value	0.00298849 (rank : 103)
Query Neighborhood Hits	297	Target Neighborhood Hits	160	Shared Neighborhood Hits	125
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

NEB1_HUMAN
NC score	0.503176 (rank : 82)	θ value	8.11959e-09 (rank : 35)
Query Neighborhood Hits	297	Target Neighborhood Hits	829	Shared Neighborhood Hits	163
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

PDZK4_HUMAN
NC score	0.501193 (rank : 83)	θ value	1.29631e-06 (rank : 64)
Query Neighborhood Hits	297	Target Neighborhood Hits	165	Shared Neighborhood Hits	113
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

DVL1L_HUMAN
NC score	0.498668 (rank : 84)	θ value	7.59969e-07 (rank : 57)
Query Neighborhood Hits	297	Target Neighborhood Hits	146	Shared Neighborhood Hits	114
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

PDZK4_MOUSE
NC score	0.498297 (rank : 85)	θ value	7.59969e-07 (rank : 59)
Query Neighborhood Hits	297	Target Neighborhood Hits	165	Shared Neighborhood Hits	119
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

DVL2_MOUSE
NC score	0.493177 (rank : 86)	θ value	6.43352e-06 (rank : 70)
Query Neighborhood Hits	297	Target Neighborhood Hits	233	Shared Neighborhood Hits	119
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_HUMAN
NC score	0.492865 (rank : 87)	θ value	8.40245e-06 (rank : 71)
Query Neighborhood Hits	297	Target Neighborhood Hits	223	Shared Neighborhood Hits	118
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

LAP4_HUMAN
NC score	0.488508 (rank : 88)	θ value	2.60593e-15 (rank : 17)
Query Neighborhood Hits	297	Target Neighborhood Hits	608	Shared Neighborhood Hits	159
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

LAP4_MOUSE
NC score	0.486387 (rank : 89)	θ value	4.91457e-14 (rank : 22)
Query Neighborhood Hits	297	Target Neighborhood Hits	590	Shared Neighborhood Hits	157
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

NEB2_HUMAN
NC score	0.483935 (rank : 90)	θ value	4.76016e-09 (rank : 32)
Query Neighborhood Hits	297	Target Neighborhood Hits	883	Shared Neighborhood Hits	157
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEB2_MOUSE
NC score	0.478872 (rank : 91)	θ value	4.76016e-09 (rank : 33)
Query Neighborhood Hits	297	Target Neighborhood Hits	889	Shared Neighborhood Hits	161
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

MPP4_HUMAN
NC score	0.468749 (rank : 92)	θ value	0.00298849 (rank : 100)
Query Neighborhood Hits	297	Target Neighborhood Hits	205	Shared Neighborhood Hits	128
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

PTN13_HUMAN
NC score	0.460682 (rank : 93)	θ value	6.85773e-16 (rank : 11)
Query Neighborhood Hits	297	Target Neighborhood Hits	471	Shared Neighborhood Hits	165
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

APBA1_HUMAN
NC score	0.449692 (rank : 94)	θ value	0.000461057 (rank : 84)
Query Neighborhood Hits	297	Target Neighborhood Hits	325	Shared Neighborhood Hits	141
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

PTN13_MOUSE
NC score	0.447929 (rank : 95)	θ value	1.86753e-13 (rank : 23)
Query Neighborhood Hits	297	Target Neighborhood Hits	426	Shared Neighborhood Hits	159
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

DLG5_HUMAN
NC score	0.445171 (rank : 96)	θ value	1.69304e-06 (rank : 66)
Query Neighborhood Hits	297	Target Neighborhood Hits	1088	Shared Neighborhood Hits	187
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

STXB4_HUMAN
NC score	0.439351 (rank : 97)	θ value	5.81887e-07 (rank : 56)
Query Neighborhood Hits	297	Target Neighborhood Hits	616	Shared Neighborhood Hits	130
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

APBA2_MOUSE
NC score	0.439171 (rank : 98)	θ value	0.000270298 (rank : 79)
Query Neighborhood Hits	297	Target Neighborhood Hits	219	Shared Neighborhood Hits	130
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

STXB4_MOUSE
NC score	0.439015 (rank : 99)	θ value	1.29631e-06 (rank : 65)
Query Neighborhood Hits	297	Target Neighborhood Hits	629	Shared Neighborhood Hits	125
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

APBA2_HUMAN
NC score	0.437767 (rank : 100)	θ value	0.000270298 (rank : 78)
Query Neighborhood Hits	297	Target Neighborhood Hits	220	Shared Neighborhood Hits	131
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

PICK1_HUMAN
NC score	0.433032 (rank : 101)	θ value	0.0330416 (rank : 124)
Query Neighborhood Hits	297	Target Neighborhood Hits	132	Shared Neighborhood Hits	114
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

MPP5_HUMAN
NC score	0.432822 (rank : 102)	θ value	0.0148317 (rank : 115)
Query Neighborhood Hits	297	Target Neighborhood Hits	231	Shared Neighborhood Hits	134
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

PAR6B_HUMAN
NC score	0.432523 (rank : 103)	θ value	0.00134147 (rank : 91)
Query Neighborhood Hits	297	Target Neighborhood Hits	126	Shared Neighborhood Hits	115
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

MPP3_MOUSE
NC score	0.432045 (rank : 104)	θ value	0.00390308 (rank : 104)
Query Neighborhood Hits	297	Target Neighborhood Hits	165	Shared Neighborhood Hits	127
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

PICK1_MOUSE
NC score	0.431950 (rank : 105)	θ value	0.0736092 (rank : 139)
Query Neighborhood Hits	297	Target Neighborhood Hits	131	Shared Neighborhood Hits	113
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

APBA3_HUMAN
NC score	0.431738 (rank : 106)	θ value	0.000270298 (rank : 80)
Query Neighborhood Hits	297	Target Neighborhood Hits	201	Shared Neighborhood Hits	120
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

MPP5_MOUSE
NC score	0.431651 (rank : 107)	θ value	0.0148317 (rank : 116)
Query Neighborhood Hits	297	Target Neighborhood Hits	226	Shared Neighborhood Hits	134
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

MPP3_HUMAN
NC score	0.427857 (rank : 108)	θ value	0.00228821 (rank : 96)
Query Neighborhood Hits	297	Target Neighborhood Hits	171	Shared Neighborhood Hits	127
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

PAR6B_MOUSE
NC score	0.424897 (rank : 109)	θ value	0.00665767 (rank : 108)
Query Neighborhood Hits	297	Target Neighborhood Hits	128	Shared Neighborhood Hits	116
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6G_HUMAN
NC score	0.424439 (rank : 110)	θ value	0.0113563 (rank : 113)
Query Neighborhood Hits	297	Target Neighborhood Hits	159	Shared Neighborhood Hits	118
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

PAR6G_MOUSE
NC score	0.423689 (rank : 111)	θ value	0.0113563 (rank : 114)
Query Neighborhood Hits	297	Target Neighborhood Hits	121	Shared Neighborhood Hits	113
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

MPP4_MOUSE
NC score	0.422295 (rank : 112)	θ value	0.0563607 (rank : 134)
Query Neighborhood Hits	297	Target Neighborhood Hits	188	Shared Neighborhood Hits	114
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

APBA3_MOUSE
NC score	0.404052 (rank : 113)	θ value	0.00175202 (rank : 92)
Query Neighborhood Hits	297	Target Neighborhood Hits	174	Shared Neighborhood Hits	117
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

PAR6A_MOUSE
NC score	0.402208 (rank : 114)	θ value	0.0736092 (rank : 137)
Query Neighborhood Hits	297	Target Neighborhood Hits	115	Shared Neighborhood Hits	107
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

PAR6A_HUMAN
NC score	0.402166 (rank : 115)	θ value	0.0736092 (rank : 136)
Query Neighborhood Hits	297	Target Neighborhood Hits	119	Shared Neighborhood Hits	107
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

EM55_MOUSE
NC score	0.379482 (rank : 116)	θ value	0.0113563 (rank : 112)
Query Neighborhood Hits	297	Target Neighborhood Hits	221	Shared Neighborhood Hits	118
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

EM55_HUMAN
NC score	0.378845 (rank : 117)	θ value	0.0431538 (rank : 129)
Query Neighborhood Hits	297	Target Neighborhood Hits	228	Shared Neighborhood Hits	120
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

SDCB1_MOUSE
NC score	0.334607 (rank : 118)	θ value	3.0926 (rank : 213)
Query Neighborhood Hits	297	Target Neighborhood Hits	144	Shared Neighborhood Hits	113
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

SDCB1_HUMAN
NC score	0.333945 (rank : 119)	θ value	3.0926 (rank : 212)
Query Neighborhood Hits	297	Target Neighborhood Hits	150	Shared Neighborhood Hits	122
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

RPGF6_HUMAN
NC score	0.331083 (rank : 120)	θ value	0.62314 (rank : 167)
Query Neighborhood Hits	297	Target Neighborhood Hits	266	Shared Neighborhood Hits	125
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

NOS1_HUMAN
NC score	0.329049 (rank : 121)	θ value	0.000461057 (rank : 85)
Query Neighborhood Hits	297	Target Neighborhood Hits	218	Shared Neighborhood Hits	135
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

RHPN1_MOUSE
NC score	0.326225 (rank : 122)	θ value	0.00869519 (rank : 109)
Query Neighborhood Hits	297	Target Neighborhood Hits	154	Shared Neighborhood Hits	98
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

ARHGB_HUMAN
NC score	0.324019 (rank : 123)	θ value	0.000270298 (rank : 81)
Query Neighborhood Hits	297	Target Neighborhood Hits	375	Shared Neighborhood Hits	140
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

MPP6_MOUSE
NC score	0.319681 (rank : 124)	θ value	5.27518 (rank : 244)
Query Neighborhood Hits	297	Target Neighborhood Hits	187	Shared Neighborhood Hits	96
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

MPP6_HUMAN
NC score	0.311468 (rank : 125)	θ value	5.27518 (rank : 243)
Query Neighborhood Hits	297	Target Neighborhood Hits	180	Shared Neighborhood Hits	91
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP2_MOUSE
NC score	0.310994 (rank : 126)	θ value	8.99809 (rank : 290)
Query Neighborhood Hits	297	Target Neighborhood Hits	189	Shared Neighborhood Hits	95
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

PDLI2_HUMAN
NC score	0.310216 (rank : 127)	θ value	0.21417 (rank : 149)
Query Neighborhood Hits	297	Target Neighborhood Hits	245	Shared Neighborhood Hits	99
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

ARHGC_HUMAN
NC score	0.307277 (rank : 128)	θ value	0.000121331 (rank : 77)
Query Neighborhood Hits	297	Target Neighborhood Hits	351	Shared Neighborhood Hits	127
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
NC score	0.306471 (rank : 129)	θ value	5.44631e-05 (rank : 76)
Query Neighborhood Hits	297	Target Neighborhood Hits	344	Shared Neighborhood Hits	128
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

MPP2_HUMAN
NC score	0.305176 (rank : 130)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	297	Target Neighborhood Hits	173	Shared Neighborhood Hits	91
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

RHPN1_HUMAN
NC score	0.295123 (rank : 131)	θ value	0.0252991 (rank : 122)
Query Neighborhood Hits	297	Target Neighborhood Hits	158	Shared Neighborhood Hits	90
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

NOS1_MOUSE
NC score	0.291739 (rank : 132)	θ value	0.00298849 (rank : 101)
Query Neighborhood Hits	297	Target Neighborhood Hits	155	Shared Neighborhood Hits	109
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

GRASP_HUMAN
NC score	0.290925 (rank : 133)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	297	Target Neighborhood Hits	147	Shared Neighborhood Hits	92
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

GRASP_MOUSE
NC score	0.286342 (rank : 134)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	297	Target Neighborhood Hits	131	Shared Neighborhood Hits	90
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

RPGF2_HUMAN
NC score	0.283468 (rank : 135)	θ value	0.813845 (rank : 176)
Query Neighborhood Hits	297	Target Neighborhood Hits	242	Shared Neighborhood Hits	121
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

SDCB2_MOUSE
NC score	0.277069 (rank : 136)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	297	Target Neighborhood Hits	118	Shared Neighborhood Hits	100
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

PSCBP_MOUSE
NC score	0.273189 (rank : 137)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	297	Target Neighborhood Hits	118	Shared Neighborhood Hits	86
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

SDCB2_HUMAN
NC score	0.269384 (rank : 138)	θ value	6.88961 (rank : 267)
Query Neighborhood Hits	297	Target Neighborhood Hits	121	Shared Neighborhood Hits	95
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

RIMS1_HUMAN
NC score	0.268044 (rank : 139)	θ value	0.00228821 (rank : 97)
Query Neighborhood Hits	297	Target Neighborhood Hits	437	Shared Neighborhood Hits	122
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

PDLI2_MOUSE
NC score	0.258312 (rank : 140)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	297	Target Neighborhood Hits	220	Shared Neighborhood Hits	91
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

RGS12_HUMAN
NC score	0.255802 (rank : 141)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	297	Target Neighborhood Hits	333	Shared Neighborhood Hits	114
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

PSCBP_HUMAN
NC score	0.251824 (rank : 142)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	297	Target Neighborhood Hits	123	Shared Neighborhood Hits	89
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

KGUA_MOUSE
NC score	0.241641 (rank : 143)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	297	Target Neighborhood Hits	45	Shared Neighborhood Hits	26
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KGUA_HUMAN
NC score	0.240401 (rank : 144)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	297	Target Neighborhood Hits	41	Shared Neighborhood Hits	26
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

SHAN2_HUMAN
NC score	0.239109 (rank : 145)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	297	Target Neighborhood Hits	346	Shared Neighborhood Hits	100
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

SYP2L_HUMAN
NC score	0.236020 (rank : 146)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	297	Target Neighborhood Hits	400	Shared Neighborhood Hits	93
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

GIPC1_MOUSE
NC score	0.235629 (rank : 147)	θ value	0.0961366 (rank : 141)
Query Neighborhood Hits	297	Target Neighborhood Hits	92	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Z0G0	Gene names	Gipc1, Gipc, Rgs19ip1, Semcap1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Synectin) (SemaF cytoplasmic domain-associated protein 1) (SEMCAP-1).

LRRC7_HUMAN
NC score	0.235129 (rank : 148)	θ value	0.0252991 (rank : 120)
Query Neighborhood Hits	297	Target Neighborhood Hits	423	Shared Neighborhood Hits	109
SwissProt Accessions	Q96NW7, Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2	Gene names	LRRC7, KIAA1365, LAP1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

LRRC7_MOUSE
NC score	0.234172 (rank : 149)	θ value	0.0252991 (rank : 121)
Query Neighborhood Hits	297	Target Neighborhood Hits	416	Shared Neighborhood Hits	107
SwissProt Accessions	Q80TE7	Gene names	Lrrc7, Kiaa1365, Lap1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

RIMS2_HUMAN
NC score	0.229092 (rank : 150)	θ value	0.00869519 (rank : 110)
Query Neighborhood Hits	297	Target Neighborhood Hits	342	Shared Neighborhood Hits	104
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
NC score	0.226313 (rank : 151)	θ value	0.00869519 (rank : 111)
Query Neighborhood Hits	297	Target Neighborhood Hits	376	Shared Neighborhood Hits	105
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

LAP2_HUMAN
NC score	0.222162 (rank : 152)	θ value	0.365318 (rank : 158)
Query Neighborhood Hits	297	Target Neighborhood Hits	499	Shared Neighborhood Hits	111
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

GIPC1_HUMAN
NC score	0.221121 (rank : 153)	θ value	0.279714 (rank : 154)
Query Neighborhood Hits	297	Target Neighborhood Hits	91	Shared Neighborhood Hits	79
SwissProt Accessions	O14908, Q9BTC9	Gene names	GIPC1, C19orf3, GIPC, RGS19IP1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Tax interaction protein 2) (TIP-2).

SHAN2_MOUSE
NC score	0.214593 (rank : 154)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	297	Target Neighborhood Hits	446	Shared Neighborhood Hits	98
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

APXL_HUMAN
NC score	0.214004 (rank : 155)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	297	Target Neighborhood Hits	553	Shared Neighborhood Hits	97
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

PDZD6_HUMAN
NC score	0.213998 (rank : 156)	θ value	1.06291 (rank : 180)
Query Neighborhood Hits	297	Target Neighborhood Hits	81	Shared Neighborhood Hits	54
SwissProt Accessions	Q9ULD6, Q4W5I8, Q86V55	Gene names	PDZD6, KIAA1284, PDZK6
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 6.

LAP2_MOUSE
NC score	0.208147 (rank : 157)	θ value	3.0926 (rank : 209)
Query Neighborhood Hits	297	Target Neighborhood Hits	482	Shared Neighborhood Hits	104
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

SYNP2_MOUSE
NC score	0.204114 (rank : 158)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	297	Target Neighborhood Hits	252	Shared Neighborhood Hits	93
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

PCLO_MOUSE
NC score	0.200046 (rank : 159)	θ value	0.0736092 (rank : 138)
Query Neighborhood Hits	297	Target Neighborhood Hits	2275	Shared Neighborhood Hits	201
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

GIPC2_HUMAN
NC score	0.182449 (rank : 160)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	297	Target Neighborhood Hits	93	Shared Neighborhood Hits	83
SwissProt Accessions	Q8TF65, Q8IYD3, Q9NXS7	Gene names	GIPC2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2.

PDLI3_HUMAN
NC score	0.172160 (rank : 161)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	297	Target Neighborhood Hits	199	Shared Neighborhood Hits	82
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

SHAN1_HUMAN
NC score	0.169387 (rank : 162)	θ value	0.0736092 (rank : 140)
Query Neighborhood Hits	297	Target Neighborhood Hits	1041	Shared Neighborhood Hits	135
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SYP2L_MOUSE
NC score	0.166315 (rank : 163)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	297	Target Neighborhood Hits	289	Shared Neighborhood Hits	77
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

PDLI4_HUMAN
NC score	0.162043 (rank : 164)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	297	Target Neighborhood Hits	245	Shared Neighborhood Hits	81
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PDLI4_MOUSE
NC score	0.161192 (rank : 165)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	297	Target Neighborhood Hits	233	Shared Neighborhood Hits	81
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PDLI1_MOUSE
NC score	0.156076 (rank : 166)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	297	Target Neighborhood Hits	213	Shared Neighborhood Hits	74
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PDLI3_MOUSE
NC score	0.151871 (rank : 167)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	297	Target Neighborhood Hits	197	Shared Neighborhood Hits	78
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PDLI1_HUMAN
NC score	0.148918 (rank : 168)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	297	Target Neighborhood Hits	242	Shared Neighborhood Hits	73
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

SYNP2_HUMAN
NC score	0.148627 (rank : 169)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	297	Target Neighborhood Hits	323	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

PTN4_HUMAN
NC score	0.146577 (rank : 170)	θ value	0.0431538 (rank : 132)
Query Neighborhood Hits	297	Target Neighborhood Hits	303	Shared Neighborhood Hits	102
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

PDLI5_MOUSE
NC score	0.137724 (rank : 171)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	297	Target Neighborhood Hits	287	Shared Neighborhood Hits	86
SwissProt Accessions	Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2	Gene names	Pdlim5, Enh
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PTN3_HUMAN
NC score	0.137485 (rank : 172)	θ value	0.125558 (rank : 144)
Query Neighborhood Hits	297	Target Neighborhood Hits	258	Shared Neighborhood Hits	98
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

LDB3_MOUSE
NC score	0.135633 (rank : 173)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	297	Target Neighborhood Hits	510	Shared Neighborhood Hits	88
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

LDB3_HUMAN
NC score	0.134662 (rank : 174)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	297	Target Neighborhood Hits	497	Shared Neighborhood Hits	92
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

PDLI5_HUMAN
NC score	0.133421 (rank : 175)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	297	Target Neighborhood Hits	322	Shared Neighborhood Hits	90
SwissProt Accessions	Q96HC4, O60705	Gene names	PDLIM5, ENH
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

CSKP_HUMAN
NC score	0.125976 (rank : 176)	θ value	0.00134147 (rank : 89)
Query Neighborhood Hits	297	Target Neighborhood Hits	1022	Shared Neighborhood Hits	115
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKP_MOUSE
NC score	0.122657 (rank : 177)	θ value	0.00134147 (rank : 90)
Query Neighborhood Hits	297	Target Neighborhood Hits	1027	Shared Neighborhood Hits	116
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

PDLI7_HUMAN
NC score	0.121626 (rank : 178)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	297	Target Neighborhood Hits	547	Shared Neighborhood Hits	100
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

GIPC3_HUMAN
NC score	0.113013 (rank : 179)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	297	Target Neighborhood Hits	52	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TF64, O75227	Gene names	GIPC3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3.

GIPC2_MOUSE
NC score	0.111757 (rank : 180)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	297	Target Neighborhood Hits	71	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Z2H7, Q9CVG2	Gene names	Gipc2, Semcap2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2 (SemaF cytoplasmic domain- associated protein 2) (SEMCAP-2).

PDLI7_MOUSE
NC score	0.111557 (rank : 181)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	297	Target Neighborhood Hits	279	Shared Neighborhood Hits	73
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

GIPC3_MOUSE
NC score	0.108761 (rank : 182)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	297	Target Neighborhood Hits	53	Shared Neighborhood Hits	44
SwissProt Accessions	Q8R5M0	Gene names	Gipc3, Rgs19ip3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3 (Regulator of G-protein signaling 19-interacting protein 3).

PDZD8_HUMAN
NC score	0.108355 (rank : 183)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	297	Target Neighborhood Hits	185	Shared Neighborhood Hits	41
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

LMO7_HUMAN
NC score	0.106761 (rank : 184)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	297	Target Neighborhood Hits	507	Shared Neighborhood Hits	77
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

CNKR2_HUMAN
NC score	0.099060 (rank : 185)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	297	Target Neighborhood Hits	197	Shared Neighborhood Hits	49
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
NC score	0.099000 (rank : 186)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	297	Target Neighborhood Hits	197	Shared Neighborhood Hits	48
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

RGS3_HUMAN
NC score	0.092455 (rank : 187)	θ value	0.00509761 (rank : 106)
Query Neighborhood Hits	297	Target Neighborhood Hits	1375	Shared Neighborhood Hits	100
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

MY18A_MOUSE
NC score	0.091225 (rank : 188)	θ value	0.365318 (rank : 160)
Query Neighborhood Hits	297	Target Neighborhood Hits	1989	Shared Neighborhood Hits	169
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

PRAX_MOUSE
NC score	0.089894 (rank : 189)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	297	Target Neighborhood Hits	199	Shared Neighborhood Hits	50
SwissProt Accessions	O55103, O55104	Gene names	Prx
Domain Architecture
Description	Periaxin.

RNF41_MOUSE
NC score	0.088164 (rank : 190)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	297	Target Neighborhood Hits	224	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BH75, Q8BGJ2, Q8BMC9, Q8VEA2, Q9CRK6, Q9D568	Gene names	Rnf41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

RNF41_HUMAN
NC score	0.087918 (rank : 191)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	297	Target Neighborhood Hits	226	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H4P4, O75598	Gene names	RNF41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

MY18A_HUMAN
NC score	0.085272 (rank : 192)	θ value	0.365318 (rank : 159)
Query Neighborhood Hits	297	Target Neighborhood Hits	1929	Shared Neighborhood Hits	174
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

RGS3_MOUSE
NC score	0.085200 (rank : 193)	θ value	0.21417 (rank : 150)
Query Neighborhood Hits	297	Target Neighborhood Hits	1621	Shared Neighborhood Hits	117
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

CAR11_HUMAN
NC score	0.085196 (rank : 194)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	297	Target Neighborhood Hits	690	Shared Neighborhood Hits	76
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

RHPN2_MOUSE
NC score	0.084238 (rank : 195)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	297	Target Neighborhood Hits	60	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BWR8, Q9DBN2	Gene names	Rhpn2
Domain Architecture	No domain graphic available
Description	Rhophilin-2 (GTP-Rho-binding protein 2).

TIAM1_HUMAN
NC score	0.074658 (rank : 196)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	297	Target Neighborhood Hits	225	Shared Neighborhood Hits	62
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

HUTH_MOUSE
NC score	0.074577 (rank : 197)	θ value	0.00509761 (rank : 105)
Query Neighborhood Hits	297	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	P35492	Gene names	Hal, Hsd, Huth
Domain Architecture
Description	Histidine ammonia-lyase (EC 4.3.1.3) (Histidase).

HTRA3_MOUSE
NC score	0.073127 (rank : 198)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	297	Target Neighborhood Hits	156	Shared Neighborhood Hits	63
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

PRAX_HUMAN
NC score	0.070428 (rank : 199)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	297	Target Neighborhood Hits	215	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BXM0, Q9BXL9, Q9HCF2	Gene names	PRX, KIAA1620
Domain Architecture
Description	Periaxin.

HTRA3_HUMAN
NC score	0.067943 (rank : 200)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	297	Target Neighborhood Hits	152	Shared Neighborhood Hits	59
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

HUTH_HUMAN
NC score	0.065348 (rank : 201)	θ value	0.0961366 (rank : 142)
Query Neighborhood Hits	297	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	P42357	Gene names	HAL, HIS
Domain Architecture
Description	Histidine ammonia-lyase (EC 4.3.1.3) (Histidase).

CAR14_HUMAN
NC score	0.063683 (rank : 202)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	297	Target Neighborhood Hits	449	Shared Neighborhood Hits	67
SwissProt Accessions	Q9BXL6, Q9BVB5	Gene names	CARD14, CARMA2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2).

SAV1_MOUSE
NC score	0.058569 (rank : 203)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	297	Target Neighborhood Hits	48	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

SAV1_HUMAN
NC score	0.058495 (rank : 204)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	297	Target Neighborhood Hits	51	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

CACB1_MOUSE
NC score	0.056952 (rank : 205)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	297	Target Neighborhood Hits	46	Shared Neighborhood Hits	19
SwissProt Accessions	Q8R3Z5, O88517, Q7TPF2, Q8R3Z6, Q9EPT9	Gene names	Cacnb1, Cacnlb1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1).

WWC1_HUMAN
NC score	0.056261 (rank : 206)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	297	Target Neighborhood Hits	290	Shared Neighborhood Hits	29
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

PSMD9_HUMAN
NC score	0.054988 (rank : 207)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	297	Target Neighborhood Hits	36	Shared Neighborhood Hits	17
SwissProt Accessions	O00233, Q9BQ42	Gene names	PSMD9
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27).

RAIN_HUMAN
NC score	0.054916 (rank : 208)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	297	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	Q5U651, Q6U676	Gene names	RASIP1
Domain Architecture	No domain graphic available
Description	Ras-interacting protein 1 (Rain).

CACB3_HUMAN
NC score	0.054914 (rank : 209)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	297	Target Neighborhood Hits	45	Shared Neighborhood Hits	17
SwissProt Accessions	P54284, Q13913	Gene names	CACNB3, CACNLB3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3).

CACB3_MOUSE
NC score	0.054850 (rank : 210)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	297	Target Neighborhood Hits	48	Shared Neighborhood Hits	18
SwissProt Accessions	P54285	Gene names	Cacnb3, Cacnlb3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3) (CCHB3).

CACB1_HUMAN
NC score	0.054327 (rank : 211)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	297	Target Neighborhood Hits	44	Shared Neighborhood Hits	20
SwissProt Accessions	Q02641, O15331, Q02639, Q02640, Q9C085	Gene names	CACNB1, CACNLB1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1).

CCD93_MOUSE
NC score	0.053922 (rank : 212)	θ value	0.279714 (rank : 152)
Query Neighborhood Hits	297	Target Neighborhood Hits	362	Shared Neighborhood Hits	38
SwissProt Accessions	Q7TQK5, Q3TX53	Gene names	Ccdc93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

RAIN_MOUSE
NC score	0.053784 (rank : 213)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	297	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q3U0S6, Q6GQW4	Gene names	Rasip1
Domain Architecture	No domain graphic available
Description	Ras-interacting protein 1 (Rain).

CACB4_HUMAN
NC score	0.053740 (rank : 214)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	297	Target Neighborhood Hits	47	Shared Neighborhood Hits	18
SwissProt Accessions	O00305, O60515, Q96L40	Gene names	CACNB4, CACNLB4
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4).

WWC1_MOUSE
NC score	0.053739 (rank : 215)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	297	Target Neighborhood Hits	290	Shared Neighborhood Hits	22
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

CAR14_MOUSE
NC score	0.053061 (rank : 216)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	297	Target Neighborhood Hits	526	Shared Neighborhood Hits	59
SwissProt Accessions	Q99KF0	Gene names	Card14, Bimp2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (Bcl10-interacting MAGUK protein 2) (Bimp2).

FRMD1_HUMAN
NC score	0.052549 (rank : 217)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	297	Target Neighborhood Hits	48	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N878, Q5SZU7, Q9UFB0	Gene names	FRMD1
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 1.

CACB4_MOUSE
NC score	0.052095 (rank : 218)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	297	Target Neighborhood Hits	42	Shared Neighborhood Hits	17
SwissProt Accessions	Q8R0S4, Q8BRN6, Q8CAJ9	Gene names	Cacnb4, Cacnlb4
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4).

WIRE_MOUSE
NC score	0.051989 (rank : 219)	θ value	0.21417 (rank : 151)
Query Neighborhood Hits	297	Target Neighborhood Hits	310	Shared Neighborhood Hits	22
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

LRRC1_MOUSE
NC score	0.051381 (rank : 220)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	297	Target Neighborhood Hits	281	Shared Neighborhood Hits	8
SwissProt Accessions	Q80VQ1, Q3UI50, Q8BKR1, Q8BUS9	Gene names	Lrrc1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 1.

IF2M_MOUSE
NC score	0.051267 (rank : 221)	θ value	0.00298849 (rank : 99)
Query Neighborhood Hits	297	Target Neighborhood Hits	183	Shared Neighborhood Hits	10
SwissProt Accessions	Q91YJ5	Gene names	Mtif2
Domain Architecture
Description	Translation initiation factor IF-2, mitochondrial precursor (IF-2Mt) (IF-2(Mt)).

LRRC1_HUMAN
NC score	0.050952 (rank : 222)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	297	Target Neighborhood Hits	282	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BTT6, Q9HAC0, Q9NVF1	Gene names	LRRC1, LANO
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 1 (LAP and no PDZ protein) (LANO adapter protein).

CRK_HUMAN
NC score	0.050543 (rank : 223)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	297	Target Neighborhood Hits	308	Shared Neighborhood Hits	24
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

TIAM1_MOUSE
NC score	0.050340 (rank : 224)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	297	Target Neighborhood Hits	205	Shared Neighborhood Hits	44
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

YAP1_MOUSE
NC score	0.050204 (rank : 225)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	297	Target Neighborhood Hits	96	Shared Neighborhood Hits	11
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

CRK_MOUSE
NC score	0.050115 (rank : 226)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	297	Target Neighborhood Hits	314	Shared Neighborhood Hits	25
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CIKS_HUMAN
NC score	0.049587 (rank : 227)	θ value	0.279714 (rank : 153)
Query Neighborhood Hits	297	Target Neighborhood Hits	60	Shared Neighborhood Hits	9
SwissProt Accessions	O43734, Q5R3A3, Q9H5W2, Q9H6Y3, Q9NS14, Q9UG72	Gene names	TRAF3IP2, C6orf4, C6orf5
Domain Architecture	No domain graphic available
Description	Adapter protein CIKS (Connection to IKK and SAPK/JNK) (TRAF3- interacting protein 2) (Nuclear factor NF-kappa-B activator 1) (ACT1).

DMP1_HUMAN
NC score	0.049414 (rank : 228)	θ value	0.0330416 (rank : 123)
Query Neighborhood Hits	297	Target Neighborhood Hits	491	Shared Neighborhood Hits	21
SwissProt Accessions	Q13316, O43265	Gene names	DMP1
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1).

PTN23_MOUSE
NC score	0.049359 (rank : 229)	θ value	4.03905 (rank : 231)
Query Neighborhood Hits	297	Target Neighborhood Hits	726	Shared Neighborhood Hits	55
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

CCD93_HUMAN
NC score	0.048984 (rank : 230)	θ value	0.21417 (rank : 148)
Query Neighborhood Hits	297	Target Neighborhood Hits	600	Shared Neighborhood Hits	44
SwissProt Accessions	Q567U6, Q4LE78, Q53TJ2, Q8TBX5, Q9H6R5, Q9NV15	Gene names	CCDC93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

PRPC_HUMAN
NC score	0.048080 (rank : 231)	θ value	2.36792 (rank : 194)
Query Neighborhood Hits	297	Target Neighborhood Hits	165	Shared Neighborhood Hits	19
SwissProt Accessions	P02810, Q4VBP2, Q53XA2, Q6P2F6	Gene names	PRH1
Domain Architecture	No domain graphic available
Description	Salivary acidic proline-rich phosphoprotein 1/2 precursor (PRP-1/PRP- 2) (Parotid proline-rich protein 1/2) (Pr1/Pr2) (Protein C) (Parotid acidic protein) (Pa) (Parotid isoelectric focusing variant protein) (PIF-S) (Parotid double-band protein) (Db-s) [Contains: Salivary acidic proline-rich phosphoprotein 1/2; Salivary acidic proline-rich phosphoprotein 3/4 (PRP-3/PRP-4) (Protein A) (PIF-F) (Db-F); Peptide P-C].

WIRE_HUMAN
NC score	0.046792 (rank : 232)	θ value	0.813845 (rank : 177)
Query Neighborhood Hits	297	Target Neighborhood Hits	329	Shared Neighborhood Hits	23
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

RPTN_MOUSE
NC score	0.045242 (rank : 233)	θ value	2.36792 (rank : 195)
Query Neighborhood Hits	297	Target Neighborhood Hits	650	Shared Neighborhood Hits	45
SwissProt Accessions	P97347	Gene names	Rptn
Domain Architecture
Description	Repetin.

E41LA_HUMAN
NC score	0.044639 (rank : 234)	θ value	1.81305 (rank : 190)
Query Neighborhood Hits	297	Target Neighborhood Hits	87	Shared Neighborhood Hits	13
SwissProt Accessions	Q9HCS5	Gene names	EPB41L4A, EPB41L4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

ITSN1_MOUSE
NC score	0.043122 (rank : 235)	θ value	3.0926 (rank : 206)
Query Neighborhood Hits	297	Target Neighborhood Hits	1669	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

CABIN_HUMAN
NC score	0.042697 (rank : 236)	θ value	0.47712 (rank : 161)
Query Neighborhood Hits	297	Target Neighborhood Hits	490	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

TACC3_HUMAN
NC score	0.041374 (rank : 237)	θ value	1.38821 (rank : 187)
Query Neighborhood Hits	297	Target Neighborhood Hits	779	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

PCLO_HUMAN
NC score	0.040250 (rank : 238)	θ value	4.03905 (rank : 228)
Query Neighborhood Hits	297	Target Neighborhood Hits	2046	Shared Neighborhood Hits	105
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

41_MOUSE
NC score	0.039954 (rank : 239)	θ value	0.813845 (rank : 168)
Query Neighborhood Hits	297	Target Neighborhood Hits	184	Shared Neighborhood Hits	12
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

SMC3_MOUSE
NC score	0.039768 (rank : 240)	θ value	1.38821 (rank : 186)
Query Neighborhood Hits	297	Target Neighborhood Hits	1187	Shared Neighborhood Hits	62
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

SMC3_HUMAN
NC score	0.039759 (rank : 241)	θ value	1.38821 (rank : 185)
Query Neighborhood Hits	297	Target Neighborhood Hits	1186	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

ZIM10_MOUSE
NC score	0.039568 (rank : 242)	θ value	0.0330416 (rank : 126)
Query Neighborhood Hits	297	Target Neighborhood Hits	430	Shared Neighborhood Hits	39
SwissProt Accessions	Q6P1E1, Q6PDK9, Q6PF85, Q8BW47	Gene names	Rai17, Zimp10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

FLIP1_MOUSE
NC score	0.039538 (rank : 243)	θ value	0.813845 (rank : 172)
Query Neighborhood Hits	297	Target Neighborhood Hits	1176	Shared Neighborhood Hits	62
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

GOGA4_HUMAN
NC score	0.039415 (rank : 244)	θ value	0.47712 (rank : 163)
Query Neighborhood Hits	297	Target Neighborhood Hits	2034	Shared Neighborhood Hits	86
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

SMC1A_HUMAN
NC score	0.038850 (rank : 245)	θ value	0.163984 (rank : 146)
Query Neighborhood Hits	297	Target Neighborhood Hits	1346	Shared Neighborhood Hits	69
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

CO5A1_HUMAN
NC score	0.038632 (rank : 246)	θ value	0.0563607 (rank : 133)
Query Neighborhood Hits	297	Target Neighborhood Hits	434	Shared Neighborhood Hits	29
SwissProt Accessions	P20908, Q15094, Q5SUX4	Gene names	COL5A1
Domain Architecture
Description	Collagen alpha-1(V) chain precursor.

CO5A1_MOUSE
NC score	0.038628 (rank : 247)	θ value	0.0431538 (rank : 128)
Query Neighborhood Hits	297	Target Neighborhood Hits	419	Shared Neighborhood Hits	29
SwissProt Accessions	O88207	Gene names	Col5a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(V) chain precursor.

NU214_HUMAN
NC score	0.038566 (rank : 248)	θ value	0.279714 (rank : 155)
Query Neighborhood Hits	297	Target Neighborhood Hits	657	Shared Neighborhood Hits	33
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

PHLB1_HUMAN
NC score	0.037703 (rank : 249)	θ value	0.279714 (rank : 156)
Query Neighborhood Hits	297	Target Neighborhood Hits	1038	Shared Neighborhood Hits	69
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

IDLC_MOUSE
NC score	0.037311 (rank : 250)	θ value	4.03905 (rank : 223)
Query Neighborhood Hits	297	Target Neighborhood Hits	321	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BVN8	Gene names	Dnali1
Domain Architecture	No domain graphic available
Description	Axonemal dynein light intermediate polypeptide 1 (Inner dynein arm light chain, axonemal).

SMC1A_MOUSE
NC score	0.037277 (rank : 251)	θ value	0.163984 (rank : 147)
Query Neighborhood Hits	297	Target Neighborhood Hits	1384	Shared Neighborhood Hits	70
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

TCAL5_HUMAN
NC score	0.036772 (rank : 252)	θ value	0.0330416 (rank : 125)
Query Neighborhood Hits	297	Target Neighborhood Hits	806	Shared Neighborhood Hits	43
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

FLIP1_HUMAN
NC score	0.036232 (rank : 253)	θ value	0.47712 (rank : 162)
Query Neighborhood Hits	297	Target Neighborhood Hits	1405	Shared Neighborhood Hits	67
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

GOGA4_MOUSE
NC score	0.035281 (rank : 254)	θ value	3.0926 (rank : 204)
Query Neighborhood Hits	297	Target Neighborhood Hits	1939	Shared Neighborhood Hits	86
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

RRBP1_MOUSE
NC score	0.035227 (rank : 255)	θ value	2.36792 (rank : 196)
Query Neighborhood Hits	297	Target Neighborhood Hits	1650	Shared Neighborhood Hits	94
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

PHF20_HUMAN
NC score	0.035160 (rank : 256)	θ value	0.47712 (rank : 164)
Query Neighborhood Hits	297	Target Neighborhood Hits	394	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BVI0, Q5JWY9, Q9BWV4, Q9BXA3, Q9BZW3, Q9H421, Q9H4J6, Q9NZ22	Gene names	PHF20, C20orf104, GLEA2, HCA58, NZF, TZP
Domain Architecture
Description	PHD finger protein 20 (Hepatocellular carcinoma-associated antigen 58) (Glioma-expressed antigen 2) (Transcription factor TZP) (Novel zinc finger protein).

RFIP4_HUMAN
NC score	0.034438 (rank : 257)	θ value	5.27518 (rank : 249)
Query Neighborhood Hits	297	Target Neighborhood Hits	785	Shared Neighborhood Hits	53
SwissProt Accessions	Q86YS3, Q8N829, Q8NDT7, Q969D8	Gene names	RAB11FIP4, KIAA1821
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 4 (Rab11-FIP4).

CCD21_HUMAN
NC score	0.033751 (rank : 258)	θ value	0.813845 (rank : 169)
Query Neighborhood Hits	297	Target Neighborhood Hits	1228	Shared Neighborhood Hits	65
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

SF3B2_HUMAN
NC score	0.033588 (rank : 259)	θ value	3.0926 (rank : 214)
Query Neighborhood Hits	297	Target Neighborhood Hits	157	Shared Neighborhood Hits	15
SwissProt Accessions	Q13435	Gene names	SF3B2, SAP145
Domain Architecture
Description	Splicing factor 3B subunit 2 (Spliceosome-associated protein 145) (SAP 145) (SF3b150) (Pre-mRNA-splicing factor SF3b 145 kDa subunit).

RRBP1_HUMAN
NC score	0.033200 (rank : 260)	θ value	1.06291 (rank : 181)
Query Neighborhood Hits	297	Target Neighborhood Hits	1306	Shared Neighborhood Hits	77
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

DIDO1_HUMAN
NC score	0.032801 (rank : 261)	θ value	6.88961 (rank : 256)
Query Neighborhood Hits	297	Target Neighborhood Hits	960	Shared Neighborhood Hits	61
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

HOOK3_MOUSE
NC score	0.032775 (rank : 262)	θ value	1.81305 (rank : 191)
Query Neighborhood Hits	297	Target Neighborhood Hits	1007	Shared Neighborhood Hits	65
SwissProt Accessions	Q8BUK6, Q8BV48, Q8BW57, Q8BY41	Gene names	Hook3
Domain Architecture
Description	Hook homolog 3.

PRP1_HUMAN
NC score	0.032753 (rank : 263)	θ value	5.27518 (rank : 247)
Query Neighborhood Hits	297	Target Neighborhood Hits	385	Shared Neighborhood Hits	30
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

CTGE4_HUMAN
NC score	0.032346 (rank : 264)	θ value	0.813845 (rank : 170)
Query Neighborhood Hits	297	Target Neighborhood Hits	393	Shared Neighborhood Hits	34
SwissProt Accessions	Q8IX94, O95046	Gene names	CTAGE4
Domain Architecture	No domain graphic available
Description	Cutaneous T-cell lymphoma-associated antigen 4 (cTAGE-4 protein).

CTGE6_HUMAN
NC score	0.032200 (rank : 265)	θ value	4.03905 (rank : 221)
Query Neighborhood Hits	297	Target Neighborhood Hits	650	Shared Neighborhood Hits	52
SwissProt Accessions	Q86UF2	Gene names	CTAGE6
Domain Architecture	No domain graphic available
Description	Protein cTAGE-6 (cTAGE family member 6).

HOOK3_HUMAN
NC score	0.032153 (rank : 266)	θ value	6.88961 (rank : 259)
Query Neighborhood Hits	297	Target Neighborhood Hits	1070	Shared Neighborhood Hits	67
SwissProt Accessions	Q86VS8, Q8NBH0, Q9BY13	Gene names	HOOK3
Domain Architecture
Description	Hook homolog 3 (hHK3).

PEPL_MOUSE
NC score	0.031681 (rank : 267)	θ value	4.03905 (rank : 229)
Query Neighborhood Hits	297	Target Neighborhood Hits	1105	Shared Neighborhood Hits	65
SwissProt Accessions	Q9R269, O70231, Q9CUT1, Q9JLZ7	Gene names	Ppl
Domain Architecture
Description	Periplakin.

COBA1_HUMAN
NC score	0.031517 (rank : 268)	θ value	1.06291 (rank : 178)
Query Neighborhood Hits	297	Target Neighborhood Hits	491	Shared Neighborhood Hits	36
SwissProt Accessions	P12107, Q14034, Q9UIT4, Q9UIT5, Q9UIT6	Gene names	COL11A1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

RB6I2_HUMAN
NC score	0.031340 (rank : 269)	θ value	0.813845 (rank : 175)
Query Neighborhood Hits	297	Target Neighborhood Hits	1584	Shared Neighborhood Hits	71
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

ARI1A_HUMAN
NC score	0.031081 (rank : 270)	θ value	5.27518 (rank : 235)
Query Neighborhood Hits	297	Target Neighborhood Hits	787	Shared Neighborhood Hits	52
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

PODXL_MOUSE
NC score	0.031015 (rank : 271)	θ value	0.813845 (rank : 174)
Query Neighborhood Hits	297	Target Neighborhood Hits	130	Shared Neighborhood Hits	7
SwissProt Accessions	Q9R0M4, Q9ESZ1	Gene names	Podxl, Pclp1
Domain Architecture
Description	Podocalyxin-like protein 1 precursor.

COBA1_MOUSE
NC score	0.030787 (rank : 272)	θ value	1.06291 (rank : 179)
Query Neighborhood Hits	297	Target Neighborhood Hits	487	Shared Neighborhood Hits	37
SwissProt Accessions	Q61245, Q64047	Gene names	Col11a1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

CCD21_MOUSE
NC score	0.030674 (rank : 273)	θ value	8.99809 (rank : 274)
Query Neighborhood Hits	297	Target Neighborhood Hits	1135	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CT2NL_HUMAN
NC score	0.030625 (rank : 274)	θ value	0.62314 (rank : 166)
Query Neighborhood Hits	297	Target Neighborhood Hits	1059	Shared Neighborhood Hits	57
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

NPBL_MOUSE
NC score	0.030549 (rank : 275)	θ value	4.03905 (rank : 227)
Query Neighborhood Hits	297	Target Neighborhood Hits	1041	Shared Neighborhood Hits	60
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

PRR8_HUMAN
NC score	0.029656 (rank : 276)	θ value	4.03905 (rank : 230)
Query Neighborhood Hits	297	Target Neighborhood Hits	217	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NSV0	Gene names	PRR8
Domain Architecture	No domain graphic available
Description	Proline-rich protein 8.

ZIM10_HUMAN
NC score	0.029385 (rank : 277)	θ value	3.0926 (rank : 219)
Query Neighborhood Hits	297	Target Neighborhood Hits	577	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ULJ6, Q7Z7E6	Gene names	RAI17, KIAA1224, ZIMP10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

CI093_HUMAN
NC score	0.029077 (rank : 278)	θ value	8.99809 (rank : 276)
Query Neighborhood Hits	297	Target Neighborhood Hits	1088	Shared Neighborhood Hits	59
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

PHF20_MOUSE
NC score	0.028956 (rank : 279)	θ value	1.38821 (rank : 184)
Query Neighborhood Hits	297	Target Neighborhood Hits	513	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BLG0, Q8BMA2, Q8BYR4, Q921N1	Gene names	Phf20, Hca58
Domain Architecture
Description	PHD finger protein 20 (Hepatocellular carcinoma-associated antigen 58 homolog).

CCD46_MOUSE
NC score	0.028271 (rank : 280)	θ value	8.99809 (rank : 275)
Query Neighborhood Hits	297	Target Neighborhood Hits	1405	Shared Neighborhood Hits	68
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

IDLC_HUMAN
NC score	0.027332 (rank : 281)	θ value	6.88961 (rank : 260)
Query Neighborhood Hits	297	Target Neighborhood Hits	348	Shared Neighborhood Hits	31
SwissProt Accessions	O14645, Q5TGH0, Q7L0I5	Gene names	DNALI1
Domain Architecture	No domain graphic available
Description	Axonemal dynein light intermediate polypeptide 1 (Inner dynein arm light chain, axonemal) (hp28).

CCD91_MOUSE
NC score	0.026762 (rank : 282)	θ value	3.0926 (rank : 200)
Query Neighborhood Hits	297	Target Neighborhood Hits	699	Shared Neighborhood Hits	48
SwissProt Accessions	Q9D8L5, Q8R3N8, Q9D9E8	Gene names	Ccdc91, Ggabp
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner).

TB182_HUMAN
NC score	0.026426 (rank : 283)	θ value	4.03905 (rank : 233)
Query Neighborhood Hits	297	Target Neighborhood Hits	414	Shared Neighborhood Hits	31
SwissProt Accessions	Q9C0C2	Gene names	TNKS1BP1, KIAA1741, TAB182
Domain Architecture	No domain graphic available
Description	182 kDa tankyrase 1-binding protein.

TACC1_HUMAN
NC score	0.025352 (rank : 284)	θ value	8.99809 (rank : 295)
Query Neighborhood Hits	297	Target Neighborhood Hits	597	Shared Neighborhood Hits	45
SwissProt Accessions	O75410, Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2, Q8NEY7, Q9UPP9	Gene names	TACC1, KIAA1103
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 1 (Taxin 1) (Gastric cancer antigen Ga55).

TTF2_MOUSE
NC score	0.025149 (rank : 285)	θ value	0.0961366 (rank : 143)
Query Neighborhood Hits	297	Target Neighborhood Hits	364	Shared Neighborhood Hits	28
SwissProt Accessions	Q5NC05, Q5M924	Gene names	Ttf2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2).

TEX9_HUMAN
NC score	0.023138 (rank : 286)	θ value	6.88961 (rank : 269)
Query Neighborhood Hits	297	Target Neighborhood Hits	541	Shared Neighborhood Hits	45
SwissProt Accessions	Q8N6V9	Gene names	TEX9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein.

TACC1_MOUSE
NC score	0.022866 (rank : 287)	θ value	6.88961 (rank : 268)
Query Neighborhood Hits	297	Target Neighborhood Hits	667	Shared Neighborhood Hits	46
SwissProt Accessions	Q6Y685, Q6Y686	Gene names	Tacc1
Domain Architecture	No domain graphic available
Description	Transforming acidic coiled-coil-containing protein 1.

CO5A2_HUMAN
NC score	0.022721 (rank : 288)	θ value	5.27518 (rank : 237)
Query Neighborhood Hits	297	Target Neighborhood Hits	760	Shared Neighborhood Hits	47
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

RERE_HUMAN
NC score	0.022280 (rank : 289)	θ value	4.03905 (rank : 232)
Query Neighborhood Hits	297	Target Neighborhood Hits	779	Shared Neighborhood Hits	48
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

CN155_HUMAN
NC score	0.022010 (rank : 290)	θ value	6.88961 (rank : 254)
Query Neighborhood Hits	297	Target Neighborhood Hits	385	Shared Neighborhood Hits	21
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

TCAL3_HUMAN
NC score	0.021910 (rank : 291)	θ value	4.03905 (rank : 234)
Query Neighborhood Hits	297	Target Neighborhood Hits	274	Shared Neighborhood Hits	12
SwissProt Accessions	Q969E4	Gene names	TCEAL3
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 3 (TCEA-like protein 3) (Transcription elongation factor S-II protein-like 3).

ANLN_MOUSE
NC score	0.021755 (rank : 292)	θ value	1.38821 (rank : 182)
Query Neighborhood Hits	297	Target Neighborhood Hits	297	Shared Neighborhood Hits	19
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

LIPA3_MOUSE
NC score	0.021037 (rank : 293)	θ value	6.88961 (rank : 263)
Query Neighborhood Hits	297	Target Neighborhood Hits	636	Shared Neighborhood Hits	48
SwissProt Accessions	P60469	Gene names	Ppfia3
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

PRR12_HUMAN
NC score	0.020874 (rank : 294)	θ value	8.99809 (rank : 293)
Query Neighborhood Hits	297	Target Neighborhood Hits	460	Shared Neighborhood Hits	26
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

BRD4_MOUSE
NC score	0.019848 (rank : 295)	θ value	6.88961 (rank : 252)
Query Neighborhood Hits	297	Target Neighborhood Hits	845	Shared Neighborhood Hits	61
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

COAA1_MOUSE
NC score	0.019778 (rank : 296)	θ value	3.0926 (rank : 202)
Query Neighborhood Hits	297	Target Neighborhood Hits	286	Shared Neighborhood Hits	23
SwissProt Accessions	Q05306	Gene names	Col10a1
Domain Architecture
Description	Collagen alpha-1(X) chain precursor.

KIF4A_HUMAN
NC score	0.019718 (rank : 297)	θ value	3.0926 (rank : 207)
Query Neighborhood Hits	297	Target Neighborhood Hits	1159	Shared Neighborhood Hits	61
SwissProt Accessions	O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3	Gene names	KIF4A, KIF4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

CO4A2_HUMAN
NC score	0.019523 (rank : 298)	θ value	3.0926 (rank : 201)
Query Neighborhood Hits	297	Target Neighborhood Hits	454	Shared Neighborhood Hits	33
SwissProt Accessions	P08572	Gene names	COL4A2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

ARHGA_HUMAN
NC score	0.019500 (rank : 299)	θ value	3.0926 (rank : 198)
Query Neighborhood Hits	297	Target Neighborhood Hits	187	Shared Neighborhood Hits	10
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

CO4A1_MOUSE
NC score	0.019484 (rank : 300)	θ value	6.88961 (rank : 255)
Query Neighborhood Hits	297	Target Neighborhood Hits	450	Shared Neighborhood Hits	30
SwissProt Accessions	P02463	Gene names	Col4a1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

BPAEA_HUMAN
NC score	0.019480 (rank : 301)	θ value	5.27518 (rank : 236)
Query Neighborhood Hits	297	Target Neighborhood Hits	1369	Shared Neighborhood Hits	65
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

GLE1_MOUSE
NC score	0.019298 (rank : 302)	θ value	8.99809 (rank : 282)
Query Neighborhood Hits	297	Target Neighborhood Hits	504	Shared Neighborhood Hits	38
SwissProt Accessions	Q8R322, Q3TT10, Q3TU23, Q3UD65, Q8BT16, Q9D4A6	Gene names	Gle1l
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein).

APC_MOUSE
NC score	0.019250 (rank : 303)	θ value	6.88961 (rank : 251)
Query Neighborhood Hits	297	Target Neighborhood Hits	441	Shared Neighborhood Hits	40
SwissProt Accessions	Q61315, Q62044	Gene names	Apc
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC) (mAPC).

MYH3_HUMAN
NC score	0.018911 (rank : 304)	θ value	6.88961 (rank : 265)
Query Neighborhood Hits	297	Target Neighborhood Hits	1660	Shared Neighborhood Hits	72
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

COIA1_HUMAN
NC score	0.018855 (rank : 305)	θ value	8.99809 (rank : 279)
Query Neighborhood Hits	297	Target Neighborhood Hits	447	Shared Neighborhood Hits	30
SwissProt Accessions	P39060, Q9UK38, Q9Y6Q7, Q9Y6Q8	Gene names	COL18A1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

KIF4A_MOUSE
NC score	0.018796 (rank : 306)	θ value	3.0926 (rank : 208)
Query Neighborhood Hits	297	Target Neighborhood Hits	1033	Shared Neighborhood Hits	59
SwissProt Accessions	P33174	Gene names	Kif4a, Kif4, Kns4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

CO4A2_MOUSE
NC score	0.018676 (rank : 307)	θ value	8.99809 (rank : 278)
Query Neighborhood Hits	297	Target Neighborhood Hits	492	Shared Neighborhood Hits	37
SwissProt Accessions	P08122, Q61375	Gene names	Col4a2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

MYH7_HUMAN
NC score	0.018544 (rank : 308)	θ value	4.03905 (rank : 225)
Query Neighborhood Hits	297	Target Neighborhood Hits	1559	Shared Neighborhood Hits	65
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

SNPC1_HUMAN
NC score	0.017975 (rank : 309)	θ value	3.0926 (rank : 215)
Query Neighborhood Hits	297	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q16533	Gene names	SNAPC1, SNAP43
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 1 (SNAPc subunit 1) (snRNA- activating protein complex 43 kDa subunit) (SNAPc 43 kDa subunit) (Small nuclear RNA-activating complex polypeptide 1) (Proximal sequence element-binding transcription factor subunit gamma) (PSE- binding factor subunit gamma) (PTF subunit gamma).

CCD16_MOUSE
NC score	0.017705 (rank : 310)	θ value	4.03905 (rank : 220)
Query Neighborhood Hits	297	Target Neighborhood Hits	218	Shared Neighborhood Hits	12
SwissProt Accessions	Q8R1N0, Q3TR52, Q9CWV9, Q9CYI6	Gene names	Ccdc16, Omcg1
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 16 (Ovus mutant candidate gene 1 protein).

CJ012_HUMAN
NC score	0.017180 (rank : 311)	θ value	8.99809 (rank : 277)
Query Neighborhood Hits	297	Target Neighborhood Hits	467	Shared Neighborhood Hits	24
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

LIMK1_HUMAN
NC score	0.016817 (rank : 312)	θ value	8.99809 (rank : 286)
Query Neighborhood Hits	297	Target Neighborhood Hits	1005	Shared Neighborhood Hits	66
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

MLL3_HUMAN
NC score	0.016379 (rank : 313)	θ value	8.99809 (rank : 289)
Query Neighborhood Hits	297	Target Neighborhood Hits	1644	Shared Neighborhood Hits	73
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

RECQ5_HUMAN
NC score	0.016073 (rank : 314)	θ value	5.27518 (rank : 248)
Query Neighborhood Hits	297	Target Neighborhood Hits	390	Shared Neighborhood Hits	30
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

UBP8_HUMAN
NC score	0.015897 (rank : 315)	θ value	3.0926 (rank : 218)
Query Neighborhood Hits	297	Target Neighborhood Hits	751	Shared Neighborhood Hits	61
SwissProt Accessions	P40818, Q7Z3U2, Q86VA0, Q8IWI7	Gene names	USP8, KIAA0055, UBPY
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (hUBPy).

LIMK1_MOUSE
NC score	0.015450 (rank : 316)	θ value	8.99809 (rank : 287)
Query Neighborhood Hits	297	Target Neighborhood Hits	1008	Shared Neighborhood Hits	66
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

PLCB2_HUMAN
NC score	0.015132 (rank : 317)	θ value	3.0926 (rank : 210)
Query Neighborhood Hits	297	Target Neighborhood Hits	608	Shared Neighborhood Hits	43
SwissProt Accessions	Q00722	Gene names	PLCB2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-2) (PLC-beta-2).

TF3C1_MOUSE
NC score	0.014812 (rank : 318)	θ value	5.27518 (rank : 250)
Query Neighborhood Hits	297	Target Neighborhood Hits	92	Shared Neighborhood Hits	7
SwissProt Accessions	Q8K284, Q8CAL9	Gene names	Gtf3c1
Domain Architecture	No domain graphic available
Description	General transcription factor 3C polypeptide 1 (Transcription factor IIIC-subunit alpha) (TF3C-alpha) (TFIIIC 220 kDa subunit) (TFIIIC220) (TFIIIC box B-binding subunit).

RFTN1_HUMAN
NC score	0.014478 (rank : 319)	θ value	3.0926 (rank : 211)
Query Neighborhood Hits	297	Target Neighborhood Hits	72	Shared Neighborhood Hits	4
SwissProt Accessions	Q14699, Q496Y2, Q4QQI7, Q5JB48, Q7Z7P2	Gene names	RFTN1, KIAA0084
Domain Architecture	No domain graphic available
Description	Raftlin (Raft-linking protein) (Cell migration-inducing gene 2 protein).

FOSL1_HUMAN
NC score	0.014338 (rank : 320)	θ value	4.03905 (rank : 222)
Query Neighborhood Hits	297	Target Neighborhood Hits	112	Shared Neighborhood Hits	11
SwissProt Accessions	P15407	Gene names	FOSL1, FRA1
Domain Architecture
Description	Fos-related antigen 1 (FRA-1).

BTBD7_MOUSE
NC score	0.013802 (rank : 321)	θ value	3.0926 (rank : 199)
Query Neighborhood Hits	297	Target Neighborhood Hits	228	Shared Neighborhood Hits	14
SwissProt Accessions	Q8CFE5, Q80TC3, Q8BZY9	Gene names	Btbd7, Kiaa1525
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 7.

LSD1_HUMAN
NC score	0.013721 (rank : 322)	θ value	5.27518 (rank : 241)
Query Neighborhood Hits	297	Target Neighborhood Hits	455	Shared Neighborhood Hits	30
SwissProt Accessions	O60341, Q5TH94, Q5TH95, Q86VT7, Q8IXK4, Q8NDP6, Q8TAZ3, Q96AW4	Gene names	AOF2, KIAA0601, LSD1
Domain Architecture	No domain graphic available
Description	Lysine-specific histone demethylase 1 (EC 1.-.-.-) (Flavin-containing amine oxidase domain-containing protein 2) (BRAF35-HDAC complex protein BHC110).

LRC56_HUMAN
NC score	0.013376 (rank : 323)	θ value	6.88961 (rank : 264)
Query Neighborhood Hits	297	Target Neighborhood Hits	165	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IYG6, Q8N3Q4	Gene names	LRRC56
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 56.

LR37A_HUMAN
NC score	0.013348 (rank : 324)	θ value	5.27518 (rank : 240)
Query Neighborhood Hits	297	Target Neighborhood Hits	720	Shared Neighborhood Hits	29
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

TMC2_MOUSE
NC score	0.013158 (rank : 325)	θ value	3.0926 (rank : 217)
Query Neighborhood Hits	297	Target Neighborhood Hits	249	Shared Neighborhood Hits	17
SwissProt Accessions	Q8R4P4	Gene names	Tmc2
Domain Architecture	No domain graphic available
Description	Transmembrane cochlear-expressed protein 2.

NFAC1_HUMAN
NC score	0.012564 (rank : 326)	θ value	4.03905 (rank : 226)
Query Neighborhood Hits	297	Target Neighborhood Hits	312	Shared Neighborhood Hits	17
SwissProt Accessions	O95644, Q12865, Q15793	Gene names	NFATC1, NFAT2, NFATC
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcription complex cytosolic component) (NF-ATc1) (NF-ATc).

ITIH1_MOUSE
NC score	0.012077 (rank : 327)	θ value	1.38821 (rank : 183)
Query Neighborhood Hits	297	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q61702	Gene names	Itih1
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H1 precursor (ITI heavy chain H1) (Inter-alpha-inhibitor heavy chain 1).

LEG3_HUMAN
NC score	0.011953 (rank : 328)	θ value	6.88961 (rank : 262)
Query Neighborhood Hits	297	Target Neighborhood Hits	124	Shared Neighborhood Hits	15
SwissProt Accessions	P17931, Q16005, Q96J47	Gene names	LGALS3, MAC2
Domain Architecture
Description	Galectin-3 (Galactose-specific lectin 3) (Mac-2 antigen) (IgE-binding protein) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Laminin-binding protein) (Lectin L-29) (L-31) (Galactoside-binding protein) (GALBP).

IRX5_HUMAN
NC score	0.011527 (rank : 329)	θ value	5.27518 (rank : 239)
Query Neighborhood Hits	297	Target Neighborhood Hits	362	Shared Neighborhood Hits	15
SwissProt Accessions	P78411, P78416, Q7Z2E1	Gene names	IRX5, IRX2A, IRXB2
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-5 (Iroquois homeobox protein 5) (Homeodomain protein IRXB2) (IRX-2A).

LN28B_MOUSE
NC score	0.011116 (rank : 330)	θ value	4.03905 (rank : 224)
Query Neighborhood Hits	297	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	Q45KJ6, Q3UZC6, Q3V444	Gene names	Lin28b
Domain Architecture	No domain graphic available
Description	Lin-28 homolog B.

CD3Z_HUMAN
NC score	0.010962 (rank : 331)	θ value	6.88961 (rank : 253)
Query Neighborhood Hits	297	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	P20963, Q5VX13, Q8TAX4	Gene names	CD247, CD3Z, T3Z, TCRZ
Domain Architecture	No domain graphic available
Description	T-cell surface glycoprotein CD3 zeta chain precursor (T-cell receptor T3 zeta chain) (CD237 antigen).

HRX_HUMAN
NC score	0.010814 (rank : 332)	θ value	8.99809 (rank : 283)
Query Neighborhood Hits	297	Target Neighborhood Hits	825	Shared Neighborhood Hits	36
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

ETV3_MOUSE
NC score	0.009951 (rank : 333)	θ value	3.0926 (rank : 203)
Query Neighborhood Hits	297	Target Neighborhood Hits	128	Shared Neighborhood Hits	7
SwissProt Accessions	Q8R4Z4, Q9QZW1	Gene names	Etv3, Mets, Pe1
Domain Architecture	No domain graphic available
Description	ETS translocation variant 3 (ETS-domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor).

HCN2_HUMAN
NC score	0.009739 (rank : 334)	θ value	3.0926 (rank : 205)
Query Neighborhood Hits	297	Target Neighborhood Hits	369	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

MTFR1_MOUSE
NC score	0.009699 (rank : 335)	θ value	8.99809 (rank : 291)
Query Neighborhood Hits	297	Target Neighborhood Hits	38	Shared Neighborhood Hits	5
SwissProt Accessions	Q99MB2, Q9CQZ4	Gene names	Mtfr1, Kiaa0009
Domain Architecture	No domain graphic available
Description	Mitochondrial fission regulator 1.

TOP2B_MOUSE
NC score	0.009601 (rank : 336)	θ value	6.88961 (rank : 270)
Query Neighborhood Hits	297	Target Neighborhood Hits	80	Shared Neighborhood Hits	7
SwissProt Accessions	Q64511, Q7TQG4	Gene names	Top2b
Domain Architecture
Description	DNA topoisomerase 2-beta (EC 5.99.1.3) (DNA topoisomerase II, beta isozyme).

DJBP_MOUSE
NC score	0.008243 (rank : 337)	θ value	6.88961 (rank : 257)
Query Neighborhood Hits	297	Target Neighborhood Hits	152	Shared Neighborhood Hits	6
SwissProt Accessions	Q6P1E8, Q5DTV8, Q6PGK8, Q9D2D8	Gene names	Djbp, Kiaa1672
Domain Architecture	No domain graphic available
Description	DJ-1-binding protein.

PLS4_MOUSE
NC score	0.007873 (rank : 338)	θ value	6.88961 (rank : 266)
Query Neighborhood Hits	297	Target Neighborhood Hits	34	Shared Neighborhood Hits	5
SwissProt Accessions	P58196, Q3TMI2, Q8BH62	Gene names	Plscr4
Domain Architecture	No domain graphic available
Description	Phospholipid scramblase 4 (PL scramblase 4) (Ca(2+)-dependent phospholipid scramblase 4).

GGA3_HUMAN
NC score	0.007545 (rank : 339)	θ value	5.27518 (rank : 238)
Query Neighborhood Hits	297	Target Neighborhood Hits	127	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NZ52, Q15017, Q6IS16, Q9UJY3	Gene names	GGA3, KIAA0154
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3).

TEX14_MOUSE
NC score	0.006528 (rank : 340)	θ value	2.36792 (rank : 197)
Query Neighborhood Hits	297	Target Neighborhood Hits	1333	Shared Neighborhood Hits	41
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

HEM1_HUMAN
NC score	0.006053 (rank : 341)	θ value	6.88961 (rank : 258)
Query Neighborhood Hits	297	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	P13196	Gene names	ALAS1, ALASH
Domain Architecture
Description	5-aminolevulinate synthase, nonspecific, mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta-aminolevulinate synthase) (Delta-ALA synthetase) (ALAS-H).

IRS1_HUMAN
NC score	0.005977 (rank : 342)	θ value	8.99809 (rank : 284)
Query Neighborhood Hits	297	Target Neighborhood Hits	109	Shared Neighborhood Hits	6
SwissProt Accessions	P35568	Gene names	IRS1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

RFFL_MOUSE
NC score	0.005516 (rank : 343)	θ value	8.99809 (rank : 294)
Query Neighborhood Hits	297	Target Neighborhood Hits	145	Shared Neighborhood Hits	5
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

SLK_MOUSE
NC score	0.005063 (rank : 344)	θ value	1.81305 (rank : 193)
Query Neighborhood Hits	297	Target Neighborhood Hits	1798	Shared Neighborhood Hits	67
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

ANX11_MOUSE
NC score	0.004840 (rank : 345)	θ value	8.99809 (rank : 272)
Query Neighborhood Hits	297	Target Neighborhood Hits	200	Shared Neighborhood Hits	15
SwissProt Accessions	P97384	Gene names	Anxa11, Anx11
Domain Architecture
Description	Annexin A11 (Annexin XI) (Calcyclin-associated annexin 50) (CAP-50).

SLK_HUMAN
NC score	0.004805 (rank : 346)	θ value	1.81305 (rank : 192)
Query Neighborhood Hits	297	Target Neighborhood Hits	1775	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

IKKB_MOUSE
NC score	0.004752 (rank : 347)	θ value	0.163984 (rank : 145)
Query Neighborhood Hits	297	Target Neighborhood Hits	984	Shared Neighborhood Hits	29
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

ZEP2_HUMAN
NC score	0.004709 (rank : 348)	θ value	0.47712 (rank : 165)
Query Neighborhood Hits	297	Target Neighborhood Hits	937	Shared Neighborhood Hits	25
SwissProt Accessions	P31629, Q02646, Q5THT5, Q9NS05	Gene names	HIVEP2
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 (HIV- EP2) (MHC-binding protein 2) (MBP-2).

TF65_MOUSE
NC score	0.004571 (rank : 349)	θ value	8.99809 (rank : 296)
Query Neighborhood Hits	297	Target Neighborhood Hits	66	Shared Neighborhood Hits	5
SwissProt Accessions	Q04207, Q62025	Gene names	Rela, Nfkb3
Domain Architecture
Description	Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit).

TRI16_HUMAN
NC score	0.004026 (rank : 350)	θ value	6.88961 (rank : 271)
Query Neighborhood Hits	297	Target Neighborhood Hits	231	Shared Neighborhood Hits	10
SwissProt Accessions	O95361, Q7Z6I2, Q96BE8, Q96J43	Gene names	TRIM16, EBBP
Domain Architecture
Description	Tripartite motif-containing protein 16 (Estrogen-responsive B box protein).

IKKB_HUMAN
NC score	0.003112 (rank : 351)	θ value	0.813845 (rank : 173)
Query Neighborhood Hits	297	Target Neighborhood Hits	980	Shared Neighborhood Hits	29
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

K1C12_MOUSE
NC score	0.002312 (rank : 352)	θ value	8.99809 (rank : 285)
Query Neighborhood Hits	297	Target Neighborhood Hits	409	Shared Neighborhood Hits	30
SwissProt Accessions	Q64291	Gene names	Krt12, Krt1-12, Krt1.12
Domain Architecture
Description	Keratin, type I cytoskeletal 12 (Cytokeratin-12) (CK-12) (Keratin-12) (K12).

NMDE1_HUMAN
NC score	0.001280 (rank : 353)	θ value	8.99809 (rank : 292)
Query Neighborhood Hits	297	Target Neighborhood Hits	81	Shared Neighborhood Hits	4
SwissProt Accessions	Q12879, O00669	Gene names	GRIN2A
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 1 precursor (N-methyl D- aspartate receptor subtype 2A) (NR2A) (NMDAR2A) (hNR2A).

EHMT1_HUMAN
NC score	0.000088 (rank : 354)	θ value	8.99809 (rank : 281)
Query Neighborhood Hits	297	Target Neighborhood Hits	417	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H9B1, Q8TCN7, Q96F53, Q96JF1, Q96KH4	Gene names	EHMT1, EUHMTASE1, KIAA1876
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a- like protein 1) (GLP1).

FA12_HUMAN
NC score	-0.000224 (rank : 355)	θ value	0.813845 (rank : 171)
Query Neighborhood Hits	297	Target Neighborhood Hits	425	Shared Neighborhood Hits	4
SwissProt Accessions	P00748, P78339	Gene names	F12
Domain Architecture
Description	Coagulation factor XII precursor (EC 3.4.21.38) (Hageman factor) (HAF) [Contains: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Beta-factor XIIa part 2; Coagulation factor XIIa light chain].

LTBP4_MOUSE
NC score	-0.000829 (rank : 356)	θ value	5.27518 (rank : 242)
Query Neighborhood Hits	297	Target Neighborhood Hits	607	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K4G1, Q8K4G0	Gene names	Ltbp4
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).

PCD16_HUMAN
NC score	-0.001054 (rank : 357)	θ value	5.27518 (rank : 245)
Query Neighborhood Hits	297	Target Neighborhood Hits	245	Shared Neighborhood Hits	5
SwissProt Accessions	Q96JQ0, O15098	Gene names	DCHS1, CDH19, FIB1, KIAA1773, PCDH16
Domain Architecture
Description	Protocadherin-16 precursor (Dachsous 1) (Cadherin-19) (Fibroblast cadherin 1).

ATS18_HUMAN
NC score	-0.001307 (rank : 358)	θ value	8.99809 (rank : 273)
Query Neighborhood Hits	297	Target Neighborhood Hits	169	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TE60, Q6P4R5, Q6ZWJ9	Gene names	ADAMTS18, ADAMTS21
Domain Architecture
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).

PCDA3_HUMAN
NC score	-0.001560 (rank : 359)	θ value	5.27518 (rank : 246)
Query Neighborhood Hits	297	Target Neighborhood Hits	203	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y5H8, O75286	Gene names	PCDHA3
Domain Architecture
Description	Protocadherin alpha 3 precursor (PCDH-alpha3).

SUHW4_MOUSE
NC score	-0.002550 (rank : 360)	θ value	3.0926 (rank : 216)
Query Neighborhood Hits	297	Target Neighborhood Hits	737	Shared Neighborhood Hits	11
SwissProt Accessions	Q68FE8, Q3T9B1, Q8BI82	Gene names	Suhw4
Domain Architecture	No domain graphic available
Description	Suppressor of hairy wing homolog 4.

GLIS3_MOUSE
NC score	-0.002809 (rank : 361)	θ value	0.365318 (rank : 157)
Query Neighborhood Hits	297	Target Neighborhood Hits	861	Shared Neighborhood Hits	17
SwissProt Accessions	Q6XP49, Q8BI60	Gene names	Glis3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS3 (GLI-similar 3).

M3K15_HUMAN
NC score	-0.003536 (rank : 362)	θ value	8.99809 (rank : 288)
Query Neighborhood Hits	297	Target Neighborhood Hits	914	Shared Neighborhood Hits	15
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

KLF17_HUMAN
NC score	-0.006327 (rank : 363)	θ value	6.88961 (rank : 261)
Query Neighborhood Hits	297	Target Neighborhood Hits	882	Shared Neighborhood Hits	18
SwissProt Accessions	Q5JT82, Q86VQ7, Q8N805	Gene names	KLF17, ZNF393
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 17 (Zinc finger protein 393).

EGR1_MOUSE
NC score	-0.007302 (rank : 364)	θ value	8.99809 (rank : 280)
Query Neighborhood Hits	297	Target Neighborhood Hits	816	Shared Neighborhood Hits	14
SwissProt Accessions	P08046, Q61777	Gene names	Egr1, Egr-1, Krox-24
Domain Architecture
Description	Early growth response protein 1 (EGR-1) (Krox-24 protein) (Transcription factor Zif268) (Nerve growth factor-induced protein A) (NGFI-A).

ZN236_HUMAN
NC score	-0.008358 (rank : 365)	θ value	8.99809 (rank : 297)
Query Neighborhood Hits	297	Target Neighborhood Hits	844	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UL36, Q9UL37	Gene names	ZNF236
Domain Architecture	No domain graphic available
Description	Zinc finger protein 236.