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Network neighborhood for query Sequence : CNKR2_MOUSE

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CNKR2_MOUSE
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CNKR2_HUMAN
θ value	0 (rank : 1)	NC score	0.998533 (rank : 2)
Query Neighborhood Hits	197	Target Neighborhood Hits	197	Shared Neighborhood Hits	189
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	197	Target Neighborhood Hits	197	Shared Neighborhood Hits	197
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR1_HUMAN
θ value	5.95217e-44 (rank : 3)	NC score	0.751612 (rank : 3)
Query Neighborhood Hits	197	Target Neighborhood Hits	154	Shared Neighborhood Hits	64
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

PKHA5_HUMAN
θ value	4.91457e-14 (rank : 4)	NC score	0.433733 (rank : 5)
Query Neighborhood Hits	197	Target Neighborhood Hits	455	Shared Neighborhood Hits	71
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA6_HUMAN
θ value	7.84624e-12 (rank : 5)	NC score	0.422246 (rank : 7)
Query Neighborhood Hits	197	Target Neighborhood Hits	556	Shared Neighborhood Hits	72
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	4.30538e-10 (rank : 6)	NC score	0.402354 (rank : 8)
Query Neighborhood Hits	197	Target Neighborhood Hits	591	Shared Neighborhood Hits	73
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

MAGI2_HUMAN
θ value	1.38499e-08 (rank : 7)	NC score	0.254034 (rank : 17)
Query Neighborhood Hits	197	Target Neighborhood Hits	373	Shared Neighborhood Hits	59
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MAGI2_MOUSE
θ value	3.08544e-08 (rank : 8)	NC score	0.250805 (rank : 18)
Query Neighborhood Hits	197	Target Neighborhood Hits	370	Shared Neighborhood Hits	58
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

PKHA4_HUMAN
θ value	2.61198e-07 (rank : 9)	NC score	0.422472 (rank : 6)
Query Neighborhood Hits	197	Target Neighborhood Hits	283	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_MOUSE
θ value	2.61198e-07 (rank : 10)	NC score	0.441076 (rank : 4)
Query Neighborhood Hits	197	Target Neighborhood Hits	202	Shared Neighborhood Hits	54
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

DGKD_HUMAN
θ value	1.09739e-05 (rank : 11)	NC score	0.174406 (rank : 40)
Query Neighborhood Hits	197	Target Neighborhood Hits	231	Shared Neighborhood Hits	49
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

DGKH_HUMAN
θ value	1.09739e-05 (rank : 12)	NC score	0.202763 (rank : 31)
Query Neighborhood Hits	197	Target Neighborhood Hits	255	Shared Neighborhood Hits	72
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

GAB2_MOUSE
θ value	1.43324e-05 (rank : 13)	NC score	0.247861 (rank : 19)
Query Neighborhood Hits	197	Target Neighborhood Hits	220	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

MYO10_HUMAN
θ value	1.43324e-05 (rank : 14)	NC score	0.103987 (rank : 109)
Query Neighborhood Hits	197	Target Neighborhood Hits	920	Shared Neighborhood Hits	76
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

CYH4_HUMAN
θ value	9.29e-05 (rank : 15)	NC score	0.263260 (rank : 10)
Query Neighborhood Hits	197	Target Neighborhood Hits	135	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

CYH2_HUMAN
θ value	0.000121331 (rank : 16)	NC score	0.261987 (rank : 11)
Query Neighborhood Hits	197	Target Neighborhood Hits	175	Shared Neighborhood Hits	60
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	0.000121331 (rank : 17)	NC score	0.261970 (rank : 12)
Query Neighborhood Hits	197	Target Neighborhood Hits	171	Shared Neighborhood Hits	60
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

GAB2_HUMAN
θ value	0.000121331 (rank : 18)	NC score	0.240909 (rank : 21)
Query Neighborhood Hits	197	Target Neighborhood Hits	188	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

CYH3_HUMAN
θ value	0.00020696 (rank : 19)	NC score	0.265535 (rank : 9)
Query Neighborhood Hits	197	Target Neighborhood Hits	137	Shared Neighborhood Hits	59
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

SHAN2_MOUSE
θ value	0.000270298 (rank : 20)	NC score	0.227423 (rank : 23)
Query Neighborhood Hits	197	Target Neighborhood Hits	446	Shared Neighborhood Hits	73
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

TNKS2_HUMAN
θ value	0.00035302 (rank : 21)	NC score	0.063639 (rank : 227)
Query Neighborhood Hits	197	Target Neighborhood Hits	361	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

CYH4_MOUSE
θ value	0.000461057 (rank : 22)	NC score	0.259650 (rank : 14)
Query Neighborhood Hits	197	Target Neighborhood Hits	134	Shared Neighborhood Hits	62
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

SARM1_MOUSE
θ value	0.000461057 (rank : 23)	NC score	0.210873 (rank : 28)
Query Neighborhood Hits	197	Target Neighborhood Hits	54	Shared Neighborhood Hits	25
SwissProt Accessions	Q6PDS3, Q5SYG5, Q5SYG6, Q6A054, Q6SZW0, Q8BRI9	Gene names	Sarm1, Kiaa0524
Domain Architecture	No domain graphic available
Description	Sterile alpha and TIR motif-containing protein 1 (Tir-1 homolog).

SHAN2_HUMAN
θ value	0.000461057 (rank : 24)	NC score	0.241526 (rank : 20)
Query Neighborhood Hits	197	Target Neighborhood Hits	346	Shared Neighborhood Hits	75
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

CYH3_MOUSE
θ value	0.000602161 (rank : 25)	NC score	0.259894 (rank : 13)
Query Neighborhood Hits	197	Target Neighborhood Hits	148	Shared Neighborhood Hits	62
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

MPDZ_HUMAN
θ value	0.000602161 (rank : 26)	NC score	0.182331 (rank : 35)
Query Neighborhood Hits	197	Target Neighborhood Hits	261	Shared Neighborhood Hits	58
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

MRIP_MOUSE
θ value	0.000602161 (rank : 27)	NC score	0.190893 (rank : 34)
Query Neighborhood Hits	197	Target Neighborhood Hits	569	Shared Neighborhood Hits	61
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

GAB1_MOUSE
θ value	0.000786445 (rank : 28)	NC score	0.223244 (rank : 24)
Query Neighborhood Hits	197	Target Neighborhood Hits	233	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

CYH1_HUMAN
θ value	0.00102713 (rank : 29)	NC score	0.258985 (rank : 15)
Query Neighborhood Hits	197	Target Neighborhood Hits	184	Shared Neighborhood Hits	63
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
θ value	0.00102713 (rank : 30)	NC score	0.258540 (rank : 16)
Query Neighborhood Hits	197	Target Neighborhood Hits	176	Shared Neighborhood Hits	63
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

FGD5_MOUSE
θ value	0.00134147 (rank : 31)	NC score	0.163217 (rank : 47)
Query Neighborhood Hits	197	Target Neighborhood Hits	170	Shared Neighborhood Hits	33
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

NEB1_HUMAN
θ value	0.00134147 (rank : 32)	NC score	0.168699 (rank : 44)
Query Neighborhood Hits	197	Target Neighborhood Hits	829	Shared Neighborhood Hits	80
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

SAM14_HUMAN
θ value	0.00134147 (rank : 33)	NC score	0.239553 (rank : 22)
Query Neighborhood Hits	197	Target Neighborhood Hits	81	Shared Neighborhood Hits	22
SwissProt Accessions	Q8IZD0, Q8N2X0	Gene names	SAMD14
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 14.

SARM1_HUMAN
θ value	0.00134147 (rank : 34)	NC score	0.196338 (rank : 33)
Query Neighborhood Hits	197	Target Neighborhood Hits	58	Shared Neighborhood Hits	25
SwissProt Accessions	Q6SZW1, O60277, Q7LGG3, Q9NXY5	Gene names	SARM1, KIAA0524, SARM
Domain Architecture	No domain graphic available
Description	Sterile alpha and TIR motif-containing protein 1 (Sterile alpha and Armadillo repeat protein) (Tir-1 homolog).

FGD5_HUMAN
θ value	0.00175202 (rank : 35)	NC score	0.157230 (rank : 55)
Query Neighborhood Hits	197	Target Neighborhood Hits	235	Shared Neighborhood Hits	31
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

MAGI1_MOUSE
θ value	0.00175202 (rank : 36)	NC score	0.206241 (rank : 30)
Query Neighborhood Hits	197	Target Neighborhood Hits	403	Shared Neighborhood Hits	61
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MPDZ_MOUSE
θ value	0.00175202 (rank : 37)	NC score	0.173039 (rank : 41)
Query Neighborhood Hits	197	Target Neighborhood Hits	298	Shared Neighborhood Hits	55
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

FGD6_HUMAN
θ value	0.00298849 (rank : 38)	NC score	0.138812 (rank : 70)
Query Neighborhood Hits	197	Target Neighborhood Hits	237	Shared Neighborhood Hits	37
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

GAB1_HUMAN
θ value	0.00298849 (rank : 39)	NC score	0.219142 (rank : 26)
Query Neighborhood Hits	197	Target Neighborhood Hits	279	Shared Neighborhood Hits	37
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

DYN2_HUMAN
θ value	0.00390308 (rank : 40)	NC score	0.157120 (rank : 56)
Query Neighborhood Hits	197	Target Neighborhood Hits	112	Shared Neighborhood Hits	36
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

DYN2_MOUSE
θ value	0.00390308 (rank : 41)	NC score	0.157296 (rank : 54)
Query Neighborhood Hits	197	Target Neighborhood Hits	104	Shared Neighborhood Hits	36
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

GRIP1_HUMAN
θ value	0.00509761 (rank : 42)	NC score	0.182209 (rank : 36)
Query Neighborhood Hits	197	Target Neighborhood Hits	231	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

GRIP1_MOUSE
θ value	0.00509761 (rank : 43)	NC score	0.180902 (rank : 39)
Query Neighborhood Hits	197	Target Neighborhood Hits	241	Shared Neighborhood Hits	57
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

MAGI1_HUMAN
θ value	0.00509761 (rank : 44)	NC score	0.206742 (rank : 29)
Query Neighborhood Hits	197	Target Neighborhood Hits	388	Shared Neighborhood Hits	65
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MRIP_HUMAN
θ value	0.00509761 (rank : 45)	NC score	0.181418 (rank : 38)
Query Neighborhood Hits	197	Target Neighborhood Hits	578	Shared Neighborhood Hits	62
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

SHAN1_HUMAN
θ value	0.00509761 (rank : 46)	NC score	0.127182 (rank : 83)
Query Neighborhood Hits	197	Target Neighborhood Hits	1041	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

FGD6_MOUSE
θ value	0.00665767 (rank : 47)	NC score	0.140224 (rank : 69)
Query Neighborhood Hits	197	Target Neighborhood Hits	282	Shared Neighborhood Hits	41
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

SAM14_MOUSE
θ value	0.00869519 (rank : 48)	NC score	0.218514 (rank : 27)
Query Neighborhood Hits	197	Target Neighborhood Hits	91	Shared Neighborhood Hits	25
SwissProt Accessions	Q8K070, Q5SWB7, Q8BHE2, Q8C8N5	Gene names	Samd14
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 14.

FARP1_HUMAN
θ value	0.0113563 (rank : 49)	NC score	0.116016 (rank : 92)
Query Neighborhood Hits	197	Target Neighborhood Hits	241	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

RHG25_MOUSE
θ value	0.0113563 (rank : 50)	NC score	0.170219 (rank : 43)
Query Neighborhood Hits	197	Target Neighborhood Hits	492	Shared Neighborhood Hits	75
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_HUMAN
θ value	0.0148317 (rank : 51)	NC score	0.172830 (rank : 42)
Query Neighborhood Hits	197	Target Neighborhood Hits	550	Shared Neighborhood Hits	73
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

GRIP2_HUMAN
θ value	0.0252991 (rank : 52)	NC score	0.181558 (rank : 37)
Query Neighborhood Hits	197	Target Neighborhood Hits	256	Shared Neighborhood Hits	58
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

TNKS1_HUMAN
θ value	0.0252991 (rank : 53)	NC score	0.055347 (rank : 255)
Query Neighborhood Hits	197	Target Neighborhood Hits	477	Shared Neighborhood Hits	23
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

BFAR_HUMAN
θ value	0.0330416 (rank : 54)	NC score	0.101329 (rank : 113)
Query Neighborhood Hits	197	Target Neighborhood Hits	222	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NZS9	Gene names	BFAR, BAR, RNF47
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator (RING finger protein 47).

CSKI2_HUMAN
θ value	0.0330416 (rank : 55)	NC score	0.069791 (rank : 215)
Query Neighborhood Hits	197	Target Neighborhood Hits	747	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

LIPB1_MOUSE
θ value	0.0330416 (rank : 56)	NC score	0.084348 (rank : 160)
Query Neighborhood Hits	197	Target Neighborhood Hits	727	Shared Neighborhood Hits	45
SwissProt Accessions	Q8C8U0, Q69ZN5, Q6GQV3, Q80VB4, Q9CUT7	Gene names	Ppfibp1, Kiaa1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1).

BFAR_MOUSE
θ value	0.0431538 (rank : 57)	NC score	0.095697 (rank : 123)
Query Neighborhood Hits	197	Target Neighborhood Hits	232	Shared Neighborhood Hits	15
SwissProt Accessions	Q8R079, Q8C1A7, Q9CXY3	Gene names	Bfar
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator.

KIF1B_MOUSE
θ value	0.0431538 (rank : 58)	NC score	0.038699 (rank : 288)
Query Neighborhood Hits	197	Target Neighborhood Hits	167	Shared Neighborhood Hits	22
SwissProt Accessions	Q60575, Q9R0B4, Q9WVE5, Q9Z119	Gene names	Kif1b
Domain Architecture
Description	Kinesin-like protein KIF1B.

PLEK_HUMAN
θ value	0.0431538 (rank : 59)	NC score	0.222051 (rank : 25)
Query Neighborhood Hits	197	Target Neighborhood Hits	110	Shared Neighborhood Hits	54
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

APBA3_MOUSE
θ value	0.0563607 (rank : 60)	NC score	0.135541 (rank : 76)
Query Neighborhood Hits	197	Target Neighborhood Hits	174	Shared Neighborhood Hits	50
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

GIPC1_MOUSE
θ value	0.0563607 (rank : 61)	NC score	0.164035 (rank : 46)
Query Neighborhood Hits	197	Target Neighborhood Hits	92	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Z0G0	Gene names	Gipc1, Gipc, Rgs19ip1, Semcap1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Synectin) (SemaF cytoplasmic domain-associated protein 1) (SEMCAP-1).

TARA_MOUSE
θ value	0.0563607 (rank : 62)	NC score	0.146041 (rank : 66)
Query Neighborhood Hits	197	Target Neighborhood Hits	1133	Shared Neighborhood Hits	76
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

CSKI2_MOUSE
θ value	0.0736092 (rank : 63)	NC score	0.066374 (rank : 220)
Query Neighborhood Hits	197	Target Neighborhood Hits	812	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

DYN1_HUMAN
θ value	0.0736092 (rank : 64)	NC score	0.132647 (rank : 80)
Query Neighborhood Hits	197	Target Neighborhood Hits	216	Shared Neighborhood Hits	31
SwissProt Accessions	Q05193	Gene names	DNM1, DNM
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

DYN1_MOUSE
θ value	0.0736092 (rank : 65)	NC score	0.133383 (rank : 78)
Query Neighborhood Hits	197	Target Neighborhood Hits	168	Shared Neighborhood Hits	30
SwissProt Accessions	P39053, Q61358, Q61359, Q61360, Q8JZZ4, Q9CSY7, Q9QXX1	Gene names	Dnm1, Dnm
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

IL16_HUMAN
θ value	0.0736092 (rank : 66)	NC score	0.154255 (rank : 59)
Query Neighborhood Hits	197	Target Neighborhood Hits	207	Shared Neighborhood Hits	44
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

INADL_HUMAN
θ value	0.0736092 (rank : 67)	NC score	0.160156 (rank : 51)
Query Neighborhood Hits	197	Target Neighborhood Hits	260	Shared Neighborhood Hits	57
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

INADL_MOUSE
θ value	0.0736092 (rank : 68)	NC score	0.159753 (rank : 52)
Query Neighborhood Hits	197	Target Neighborhood Hits	290	Shared Neighborhood Hits	59
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

RAPH1_HUMAN
θ value	0.0736092 (rank : 69)	NC score	0.077869 (rank : 186)
Query Neighborhood Hits	197	Target Neighborhood Hits	593	Shared Neighborhood Hits	32
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

DYN3_HUMAN
θ value	0.0961366 (rank : 70)	NC score	0.146103 (rank : 65)
Query Neighborhood Hits	197	Target Neighborhood Hits	158	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

SAM10_HUMAN
θ value	0.0961366 (rank : 71)	NC score	0.156005 (rank : 57)
Query Neighborhood Hits	197	Target Neighborhood Hits	20	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BYL1	Gene names	SAMD10, C20orf136
Domain Architecture
Description	Sterile alpha motif domain-containing protein 10.

PDZD2_HUMAN
θ value	0.125558 (rank : 72)	NC score	0.150494 (rank : 62)
Query Neighborhood Hits	197	Target Neighborhood Hits	772	Shared Neighborhood Hits	67
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

SAM10_MOUSE
θ value	0.125558 (rank : 73)	NC score	0.149419 (rank : 64)
Query Neighborhood Hits	197	Target Neighborhood Hits	23	Shared Neighborhood Hits	14
SwissProt Accessions	Q7TST3	Gene names	Samd10
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 10.

SNTG2_HUMAN
θ value	0.125558 (rank : 74)	NC score	0.137344 (rank : 71)
Query Neighborhood Hits	197	Target Neighborhood Hits	191	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

TARA_HUMAN
θ value	0.125558 (rank : 75)	NC score	0.113210 (rank : 93)
Query Neighborhood Hits	197	Target Neighborhood Hits	1626	Shared Neighborhood Hits	86
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

GIPC2_HUMAN
θ value	0.163984 (rank : 76)	NC score	0.150452 (rank : 63)
Query Neighborhood Hits	197	Target Neighborhood Hits	93	Shared Neighborhood Hits	45
SwissProt Accessions	Q8TF65, Q8IYD3, Q9NXS7	Gene names	GIPC2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2.

GOGA6_HUMAN
θ value	0.163984 (rank : 77)	NC score	0.043868 (rank : 285)
Query Neighborhood Hits	197	Target Neighborhood Hits	1007	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NYA3, Q9NYA7	Gene names	GOLGA6, GLP
Domain Architecture
Description	Golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein).

LIPB1_HUMAN
θ value	0.163984 (rank : 78)	NC score	0.075679 (rank : 191)
Query Neighborhood Hits	197	Target Neighborhood Hits	640	Shared Neighborhood Hits	42
SwissProt Accessions	Q86W92, O75336, Q86X70, Q9NY03, Q9ULJ0	Gene names	PPFIBP1, KIAA1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2).

GIPC1_HUMAN
θ value	0.21417 (rank : 79)	NC score	0.154606 (rank : 58)
Query Neighborhood Hits	197	Target Neighborhood Hits	91	Shared Neighborhood Hits	46
SwissProt Accessions	O14908, Q9BTC9	Gene names	GIPC1, C19orf3, GIPC, RGS19IP1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Tax interaction protein 2) (TIP-2).

KIF1B_HUMAN
θ value	0.21417 (rank : 80)	NC score	0.034580 (rank : 293)
Query Neighborhood Hits	197	Target Neighborhood Hits	178	Shared Neighborhood Hits	22
SwissProt Accessions	O60333, Q96Q94, Q9BV80, Q9P280	Gene names	KIF1B, KIAA0591, KIAA1448
Domain Architecture
Description	Kinesin-like protein KIF1B (Klp).

MYH9_MOUSE
θ value	0.21417 (rank : 81)	NC score	0.032838 (rank : 294)
Query Neighborhood Hits	197	Target Neighborhood Hits	1829	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

PLEK_MOUSE
θ value	0.21417 (rank : 82)	NC score	0.198870 (rank : 32)
Query Neighborhood Hits	197	Target Neighborhood Hits	109	Shared Neighborhood Hits	47
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

PTN13_HUMAN
θ value	0.21417 (rank : 83)	NC score	0.090145 (rank : 135)
Query Neighborhood Hits	197	Target Neighborhood Hits	471	Shared Neighborhood Hits	61
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

ANKS6_MOUSE
θ value	0.279714 (rank : 84)	NC score	0.054664 (rank : 258)
Query Neighborhood Hits	197	Target Neighborhood Hits	435	Shared Neighborhood Hits	25
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

FARP2_MOUSE
θ value	0.279714 (rank : 85)	NC score	0.107958 (rank : 100)
Query Neighborhood Hits	197	Target Neighborhood Hits	209	Shared Neighborhood Hits	43
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

GIPC2_MOUSE
θ value	0.279714 (rank : 86)	NC score	0.136631 (rank : 73)
Query Neighborhood Hits	197	Target Neighborhood Hits	71	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Z2H7, Q9CVG2	Gene names	Gipc2, Semcap2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2 (SemaF cytoplasmic domain- associated protein 2) (SEMCAP-2).

GOPC_HUMAN
θ value	0.279714 (rank : 87)	NC score	0.153328 (rank : 61)
Query Neighborhood Hits	197	Target Neighborhood Hits	377	Shared Neighborhood Hits	65
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

GOPC_MOUSE
θ value	0.279714 (rank : 88)	NC score	0.153451 (rank : 60)
Query Neighborhood Hits	197	Target Neighborhood Hits	323	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

ANKS6_HUMAN
θ value	0.365318 (rank : 89)	NC score	0.054647 (rank : 259)
Query Neighborhood Hits	197	Target Neighborhood Hits	411	Shared Neighborhood Hits	24
SwissProt Accessions	Q68DC2, Q5VSL0, Q5VSL2, Q5VSL3, Q5VSL4, Q68DB8, Q6P2R2, Q8N9L6, Q96D62	Gene names	ANKS6, ANKRD14, SAMD6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6) (Ankyrin repeat domain-containing protein 14).

LIN7B_HUMAN
θ value	0.365318 (rank : 90)	NC score	0.142908 (rank : 68)
Query Neighborhood Hits	197	Target Neighborhood Hits	200	Shared Neighborhood Hits	52
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

LIPB2_MOUSE
θ value	0.365318 (rank : 91)	NC score	0.074318 (rank : 198)
Query Neighborhood Hits	197	Target Neighborhood Hits	570	Shared Neighborhood Hits	38
SwissProt Accessions	O35711, Q7TMG4, Q8CBS6, Q99KX6	Gene names	Ppfibp2, Cclp1
Domain Architecture
Description	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) (Coiled-coil-like protein 1).

SPTN4_HUMAN
θ value	0.365318 (rank : 92)	NC score	0.037722 (rank : 290)
Query Neighborhood Hits	197	Target Neighborhood Hits	570	Shared Neighborhood Hits	31
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

FARP2_HUMAN
θ value	0.62314 (rank : 93)	NC score	0.101204 (rank : 114)
Query Neighborhood Hits	197	Target Neighborhood Hits	240	Shared Neighborhood Hits	39
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

GIPC3_HUMAN
θ value	0.62314 (rank : 94)	NC score	0.133326 (rank : 79)
Query Neighborhood Hits	197	Target Neighborhood Hits	52	Shared Neighborhood Hits	31
SwissProt Accessions	Q8TF64, O75227	Gene names	GIPC3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3.

GIPC3_MOUSE
θ value	0.62314 (rank : 95)	NC score	0.132380 (rank : 81)
Query Neighborhood Hits	197	Target Neighborhood Hits	53	Shared Neighborhood Hits	32
SwissProt Accessions	Q8R5M0	Gene names	Gipc3, Rgs19ip3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3 (Regulator of G-protein signaling 19-interacting protein 3).

PZRN4_HUMAN
θ value	0.62314 (rank : 96)	NC score	0.103474 (rank : 111)
Query Neighborhood Hits	197	Target Neighborhood Hits	438	Shared Neighborhood Hits	52
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

TIAM1_HUMAN
θ value	0.62314 (rank : 97)	NC score	0.081375 (rank : 173)
Query Neighborhood Hits	197	Target Neighborhood Hits	225	Shared Neighborhood Hits	49
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	0.62314 (rank : 98)	NC score	0.072077 (rank : 208)
Query Neighborhood Hits	197	Target Neighborhood Hits	205	Shared Neighborhood Hits	39
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

URP1_HUMAN
θ value	0.62314 (rank : 99)	NC score	0.042031 (rank : 286)
Query Neighborhood Hits	197	Target Neighborhood Hits	26	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BQL6, Q8IX34, Q8IYH2, Q9NWM2, Q9NXQ3	Gene names	URP1, C20orf42, KIND1
Domain Architecture
Description	Unc-112-related protein 1 (Kindlin-1) (Kindlerin) (Kindlin syndrome protein).

AB1IP_MOUSE
θ value	0.813845 (rank : 100)	NC score	0.074152 (rank : 199)
Query Neighborhood Hits	197	Target Neighborhood Hits	181	Shared Neighborhood Hits	27
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

CA065_HUMAN
θ value	0.813845 (rank : 101)	NC score	0.048192 (rank : 275)
Query Neighborhood Hits	197	Target Neighborhood Hits	469	Shared Neighborhood Hits	20
SwissProt Accessions	Q8N715, Q8N746, Q8NA93	Gene names	C1orf65
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf65.

DYDC2_HUMAN
θ value	0.813845 (rank : 102)	NC score	0.078234 (rank : 182)
Query Neighborhood Hits	197	Target Neighborhood Hits	55	Shared Neighborhood Hits	4
SwissProt Accessions	Q96IM9, Q5QP07, Q5QP11	Gene names	DYDC2
Domain Architecture	No domain graphic available
Description	DPY30 domain-containing protein 2.

LMBL3_HUMAN
θ value	0.813845 (rank : 103)	NC score	0.046474 (rank : 280)
Query Neighborhood Hits	197	Target Neighborhood Hits	88	Shared Neighborhood Hits	14
SwissProt Accessions	Q96JM7, Q5VUM9, Q6P9B5	Gene names	L3MBTL3, KIAA1798
Domain Architecture	No domain graphic available
Description	Lethal(3)malignant brain tumor-like 3 protein (L(3)mbt-like 3 protein) (H-l(3)mbt-like protein).

LMBL3_MOUSE
θ value	0.813845 (rank : 104)	NC score	0.044836 (rank : 284)
Query Neighborhood Hits	197	Target Neighborhood Hits	212	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BLB7, Q641L7, Q6ZPI2, Q8C0G4	Gene names	L3mbtl3
Domain Architecture	No domain graphic available
Description	Lethal(3)malignant brain tumor-like 3 protein (L(3)mbt-like 3 protein).

MTMR5_HUMAN
θ value	0.813845 (rank : 105)	NC score	0.072659 (rank : 206)
Query Neighborhood Hits	197	Target Neighborhood Hits	141	Shared Neighborhood Hits	32
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

MYCB2_MOUSE
θ value	0.813845 (rank : 106)	NC score	0.035129 (rank : 292)
Query Neighborhood Hits	197	Target Neighborhood Hits	307	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TPH6, Q6PCM8	Gene names	Mycbp2, Pam, Phr1
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

MYH9_HUMAN
θ value	0.813845 (rank : 107)	NC score	0.031603 (rank : 297)
Query Neighborhood Hits	197	Target Neighborhood Hits	1762	Shared Neighborhood Hits	51
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

PKHA3_HUMAN
θ value	0.813845 (rank : 108)	NC score	0.108039 (rank : 99)
Query Neighborhood Hits	197	Target Neighborhood Hits	66	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PKHA3_MOUSE
θ value	0.813845 (rank : 109)	NC score	0.111516 (rank : 97)
Query Neighborhood Hits	197	Target Neighborhood Hits	67	Shared Neighborhood Hits	32
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PSD3_HUMAN
θ value	0.813845 (rank : 110)	NC score	0.161410 (rank : 50)
Query Neighborhood Hits	197	Target Neighborhood Hits	75	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

SMS1_HUMAN
θ value	0.813845 (rank : 111)	NC score	0.049374 (rank : 274)
Query Neighborhood Hits	197	Target Neighborhood Hits	17	Shared Neighborhood Hits	7
SwissProt Accessions	Q86VZ5	Gene names	TMEM23, MOB
Domain Architecture
Description	Phosphatidylcholine:ceramide cholinephosphotransferase 1 (EC 2.7.-.-) (Transmembrane protein 23) (Sphingomyelin synthase 1) (Mob protein).

SNTG2_MOUSE
θ value	0.813845 (rank : 112)	NC score	0.125033 (rank : 87)
Query Neighborhood Hits	197	Target Neighborhood Hits	176	Shared Neighborhood Hits	48
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SAMH1_HUMAN
θ value	1.06291 (rank : 113)	NC score	0.063109 (rank : 229)
Query Neighborhood Hits	197	Target Neighborhood Hits	14	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y3Z3, Q5JXG8, Q9H004, Q9H005, Q9H3U9	Gene names	SAMHD1, MOP5
Domain Architecture
Description	SAM domain and HD domain-containing protein 1 (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5).

SAMH1_MOUSE
θ value	1.06291 (rank : 114)	NC score	0.082019 (rank : 172)
Query Neighborhood Hits	197	Target Neighborhood Hits	19	Shared Neighborhood Hits	9
SwissProt Accessions	Q60710, Q91VK8	Gene names	Samhd1, Mg11
Domain Architecture
Description	SAM domain and HD domain-containing protein 1 (Interferon-gamma- inducible protein Mg11).

SMS1_MOUSE
θ value	1.06291 (rank : 115)	NC score	0.047124 (rank : 278)
Query Neighborhood Hits	197	Target Neighborhood Hits	18	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VCQ6, Q8C464, Q8C583, Q8C652	Gene names	Tmem23
Domain Architecture
Description	Phosphatidylcholine:ceramide cholinephosphotransferase 1 (EC 2.7.-.-) (Transmembrane protein 23) (Sphingomyelin synthase 1) (Mob protein).

TLK2_HUMAN
θ value	1.06291 (rank : 116)	NC score	0.005395 (rank : 326)
Query Neighborhood Hits	197	Target Neighborhood Hits	1044	Shared Neighborhood Hits	20
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

AKAP2_HUMAN
θ value	1.38821 (rank : 117)	NC score	0.047860 (rank : 276)
Query Neighborhood Hits	197	Target Neighborhood Hits	507	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y2D5, Q9UG26	Gene names	AKAP2, KIAA0920
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2).

AKAP2_MOUSE
θ value	1.38821 (rank : 118)	NC score	0.050449 (rank : 273)
Query Neighborhood Hits	197	Target Neighborhood Hits	385	Shared Neighborhood Hits	15
SwissProt Accessions	O54931, O54932, O54933	Gene names	Akap2
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2) (AKAP expressed in kidney and lung) (AKAP-KL).

EM55_MOUSE
θ value	1.38821 (rank : 119)	NC score	0.071792 (rank : 212)
Query Neighborhood Hits	197	Target Neighborhood Hits	221	Shared Neighborhood Hits	50
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

FKB14_HUMAN
θ value	1.38821 (rank : 120)	NC score	0.038072 (rank : 289)
Query Neighborhood Hits	197	Target Neighborhood Hits	54	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NWM8	Gene names	FKBP14, FKBP22
Domain Architecture
Description	FK506-binding protein 14 precursor (EC 5.2.1.8) (Peptidyl-prolyl cis- trans isomerase) (PPIase) (Rotamase) (22 kDa FK506-binding protein) (FKBP-22).

LIN7B_MOUSE
θ value	1.38821 (rank : 121)	NC score	0.137133 (rank : 72)
Query Neighborhood Hits	197	Target Neighborhood Hits	200	Shared Neighborhood Hits	52
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

PTN13_MOUSE
θ value	1.38821 (rank : 122)	NC score	0.084425 (rank : 158)
Query Neighborhood Hits	197	Target Neighborhood Hits	426	Shared Neighborhood Hits	60
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

STIM2_HUMAN
θ value	1.38821 (rank : 123)	NC score	0.047152 (rank : 277)
Query Neighborhood Hits	197	Target Neighborhood Hits	420	Shared Neighborhood Hits	23
SwissProt Accessions	Q9P246, Q96BF1, Q9BQH2, Q9H8R1	Gene names	STIM2, KIAA1482
Domain Architecture
Description	Stromal interaction molecule 2 precursor.

APBA3_HUMAN
θ value	1.81305 (rank : 124)	NC score	0.116133 (rank : 91)
Query Neighborhood Hits	197	Target Neighborhood Hits	201	Shared Neighborhood Hits	51
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

CE005_MOUSE
θ value	1.81305 (rank : 125)	NC score	0.031429 (rank : 298)
Query Neighborhood Hits	197	Target Neighborhood Hits	238	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

IWS1_MOUSE
θ value	1.81305 (rank : 126)	NC score	0.025045 (rank : 306)
Query Neighborhood Hits	197	Target Neighborhood Hits	1258	Shared Neighborhood Hits	33
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

LIN7C_HUMAN
θ value	1.81305 (rank : 127)	NC score	0.135986 (rank : 74)
Query Neighborhood Hits	197	Target Neighborhood Hits	198	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
θ value	1.81305 (rank : 128)	NC score	0.135986 (rank : 75)
Query Neighborhood Hits	197	Target Neighborhood Hits	198	Shared Neighborhood Hits	52
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

PKHB1_MOUSE
θ value	1.81305 (rank : 129)	NC score	0.127031 (rank : 84)
Query Neighborhood Hits	197	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

PKHB2_HUMAN
θ value	1.81305 (rank : 130)	NC score	0.144346 (rank : 67)
Query Neighborhood Hits	197	Target Neighborhood Hits	54	Shared Neighborhood Hits	32
SwissProt Accessions	Q96CS7, Q86W37, Q9BV75, Q9NWK1	Gene names	PLEKHB2, EVT2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

STIM2_MOUSE
θ value	1.81305 (rank : 131)	NC score	0.045298 (rank : 283)
Query Neighborhood Hits	197	Target Neighborhood Hits	403	Shared Neighborhood Hits	23
SwissProt Accessions	P83093, Q69ZI3, Q80VF4	Gene names	Stim2, Kiaa1482
Domain Architecture	No domain graphic available
Description	Stromal interaction molecule 2 precursor.

VIME_HUMAN
θ value	1.81305 (rank : 132)	NC score	0.015607 (rank : 317)
Query Neighborhood Hits	197	Target Neighborhood Hits	706	Shared Neighborhood Hits	28
SwissProt Accessions	P08670, Q15867, Q15868, Q15869, Q6LER9, Q8N850, Q96ML2, Q9NTM3	Gene names	VIM
Domain Architecture
Description	Vimentin.

AB1IP_HUMAN
θ value	2.36792 (rank : 133)	NC score	0.070644 (rank : 213)
Query Neighborhood Hits	197	Target Neighborhood Hits	213	Shared Neighborhood Hits	27
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

CEND3_HUMAN
θ value	2.36792 (rank : 134)	NC score	0.060726 (rank : 237)
Query Neighborhood Hits	197	Target Neighborhood Hits	275	Shared Neighborhood Hits	42
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

GNRP_HUMAN
θ value	2.36792 (rank : 135)	NC score	0.083434 (rank : 167)
Query Neighborhood Hits	197	Target Neighborhood Hits	239	Shared Neighborhood Hits	39
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

K1802_MOUSE
θ value	2.36792 (rank : 136)	NC score	0.022270 (rank : 311)
Query Neighborhood Hits	197	Target Neighborhood Hits	1596	Shared Neighborhood Hits	36
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MPP3_MOUSE
θ value	2.36792 (rank : 137)	NC score	0.078982 (rank : 177)
Query Neighborhood Hits	197	Target Neighborhood Hits	165	Shared Neighborhood Hits	48
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

OSBP2_HUMAN
θ value	2.36792 (rank : 138)	NC score	0.066058 (rank : 221)
Query Neighborhood Hits	197	Target Neighborhood Hits	154	Shared Neighborhood Hits	43
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

PKHB1_HUMAN
θ value	2.36792 (rank : 139)	NC score	0.134272 (rank : 77)
Query Neighborhood Hits	197	Target Neighborhood Hits	46	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

SDCB1_HUMAN
θ value	2.36792 (rank : 140)	NC score	0.079381 (rank : 176)
Query Neighborhood Hits	197	Target Neighborhood Hits	150	Shared Neighborhood Hits	48
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

SDCB1_MOUSE
θ value	2.36792 (rank : 141)	NC score	0.082562 (rank : 171)
Query Neighborhood Hits	197	Target Neighborhood Hits	144	Shared Neighborhood Hits	47
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

SNTG1_HUMAN
θ value	2.36792 (rank : 142)	NC score	0.124357 (rank : 88)
Query Neighborhood Hits	197	Target Neighborhood Hits	181	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SPTN2_HUMAN
θ value	2.36792 (rank : 143)	NC score	0.032769 (rank : 295)
Query Neighborhood Hits	197	Target Neighborhood Hits	535	Shared Neighborhood Hits	37
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

AKT2_HUMAN
θ value	3.0926 (rank : 144)	NC score	0.008999 (rank : 324)
Query Neighborhood Hits	197	Target Neighborhood Hits	878	Shared Neighborhood Hits	35
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

EM55_HUMAN
θ value	3.0926 (rank : 145)	NC score	0.070006 (rank : 214)
Query Neighborhood Hits	197	Target Neighborhood Hits	228	Shared Neighborhood Hits	50
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

FKB14_MOUSE
θ value	3.0926 (rank : 146)	NC score	0.031718 (rank : 296)
Query Neighborhood Hits	197	Target Neighborhood Hits	48	Shared Neighborhood Hits	4
SwissProt Accessions	P59024	Gene names	Fkbp14
Domain Architecture
Description	FK506-binding protein 14 precursor (EC 5.2.1.8) (Peptidyl-prolyl cis- trans isomerase) (PPIase) (Rotamase).

HIP1R_HUMAN
θ value	3.0926 (rank : 147)	NC score	0.027962 (rank : 300)
Query Neighborhood Hits	197	Target Neighborhood Hits	809	Shared Neighborhood Hits	35
SwissProt Accessions	O75146, Q9UED9	Gene names	HIP1R, HIP12, KIAA0655
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related) (Hip 12).

PHLB1_HUMAN
θ value	3.0926 (rank : 148)	NC score	0.083566 (rank : 166)
Query Neighborhood Hits	197	Target Neighborhood Hits	1038	Shared Neighborhood Hits	65
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

S23IP_MOUSE
θ value	3.0926 (rank : 149)	NC score	0.039525 (rank : 287)
Query Neighborhood Hits	197	Target Neighborhood Hits	363	Shared Neighborhood Hits	16
SwissProt Accessions	Q6NZC7, Q8BXY6	Gene names	Sec23ip
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein.

UTP20_HUMAN
θ value	3.0926 (rank : 150)	NC score	0.026256 (rank : 303)
Query Neighborhood Hits	197	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	O75691, Q9H3H4	Gene names	UTP20, DRIM
Domain Architecture	No domain graphic available
Description	Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Protein Key-1A6) (Novel nucleolar protein 73) (NNP73).

CSKI1_HUMAN
θ value	4.03905 (rank : 151)	NC score	0.045738 (rank : 282)
Query Neighborhood Hits	197	Target Neighborhood Hits	997	Shared Neighborhood Hits	36
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI1_MOUSE
θ value	4.03905 (rank : 152)	NC score	0.046077 (rank : 281)
Query Neighborhood Hits	197	Target Neighborhood Hits	1031	Shared Neighborhood Hits	34
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

DLG1_HUMAN
θ value	4.03905 (rank : 153)	NC score	0.090780 (rank : 132)
Query Neighborhood Hits	197	Target Neighborhood Hits	290	Shared Neighborhood Hits	53
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

K2C1_HUMAN
θ value	4.03905 (rank : 154)	NC score	0.010127 (rank : 321)
Query Neighborhood Hits	197	Target Neighborhood Hits	624	Shared Neighborhood Hits	20
SwissProt Accessions	P04264, Q14720, Q6GSJ0, Q9H298	Gene names	KRT1, KRTA
Domain Architecture
Description	Keratin, type II cytoskeletal 1 (Cytokeratin-1) (CK-1) (Keratin-1) (K1) (67 kDa cytokeratin) (Hair alpha protein).

MLTK_HUMAN
θ value	4.03905 (rank : 155)	NC score	0.006389 (rank : 325)
Query Neighborhood Hits	197	Target Neighborhood Hits	911	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

SWP70_HUMAN
θ value	4.03905 (rank : 156)	NC score	0.090262 (rank : 134)
Query Neighborhood Hits	197	Target Neighborhood Hits	973	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
θ value	4.03905 (rank : 157)	NC score	0.088081 (rank : 146)
Query Neighborhood Hits	197	Target Neighborhood Hits	1097	Shared Neighborhood Hits	71
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

VIME_MOUSE
θ value	4.03905 (rank : 158)	NC score	0.013664 (rank : 319)
Query Neighborhood Hits	197	Target Neighborhood Hits	716	Shared Neighborhood Hits	28
SwissProt Accessions	P20152, O08704, Q8CCH1	Gene names	Vim
Domain Architecture
Description	Vimentin.

CEND1_HUMAN
θ value	5.27518 (rank : 159)	NC score	0.075861 (rank : 190)
Query Neighborhood Hits	197	Target Neighborhood Hits	284	Shared Neighborhood Hits	62
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

LIN7A_HUMAN
θ value	5.27518 (rank : 160)	NC score	0.126422 (rank : 86)
Query Neighborhood Hits	197	Target Neighborhood Hits	193	Shared Neighborhood Hits	51
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7A_MOUSE
θ value	5.27518 (rank : 161)	NC score	0.126645 (rank : 85)
Query Neighborhood Hits	197	Target Neighborhood Hits	193	Shared Neighborhood Hits	51
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

MPP3_HUMAN
θ value	5.27518 (rank : 162)	NC score	0.073077 (rank : 204)
Query Neighborhood Hits	197	Target Neighborhood Hits	171	Shared Neighborhood Hits	48
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

PHLB1_MOUSE
θ value	5.27518 (rank : 163)	NC score	0.084404 (rank : 159)
Query Neighborhood Hits	197	Target Neighborhood Hits	678	Shared Neighborhood Hits	57
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PKHA2_MOUSE
θ value	5.27518 (rank : 164)	NC score	0.167753 (rank : 45)
Query Neighborhood Hits	197	Target Neighborhood Hits	116	Shared Neighborhood Hits	53
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

RBP2_MOUSE
θ value	5.27518 (rank : 165)	NC score	0.009834 (rank : 323)
Query Neighborhood Hits	197	Target Neighborhood Hits	232	Shared Neighborhood Hits	7
SwissProt Accessions	Q9ERU9, Q61992, Q8C9K9	Gene names	Ranbp2
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2 (RanBP2).

RIMS1_HUMAN
θ value	5.27518 (rank : 166)	NC score	0.046831 (rank : 279)
Query Neighborhood Hits	197	Target Neighborhood Hits	437	Shared Neighborhood Hits	52
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

S23IP_HUMAN
θ value	5.27518 (rank : 167)	NC score	0.035829 (rank : 291)
Query Neighborhood Hits	197	Target Neighborhood Hits	134	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y6Y8, Q8IXH5, Q9BUK5	Gene names	SEC23IP
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein (p125).

SSFA2_HUMAN
θ value	5.27518 (rank : 168)	NC score	0.020680 (rank : 313)
Query Neighborhood Hits	197	Target Neighborhood Hits	40	Shared Neighborhood Hits	5
SwissProt Accessions	P28290, Q96E36	Gene names	SSFA2, CS1
Domain Architecture	No domain graphic available
Description	Sperm-specific antigen 2 (Cleavage signal-1 protein) (CS-1).

TTC28_HUMAN
θ value	5.27518 (rank : 169)	NC score	0.019486 (rank : 315)
Query Neighborhood Hits	197	Target Neighborhood Hits	271	Shared Neighborhood Hits	11
SwissProt Accessions	Q96AY4, O95928, O95929, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5	Gene names	TTC28, KIAA1043
Domain Architecture
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

VATH_HUMAN
θ value	5.27518 (rank : 170)	NC score	0.024400 (rank : 308)
Query Neighborhood Hits	197	Target Neighborhood Hits	35	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UI12, Q6PK44, Q9H3E3, Q9Y300	Gene names	ATP6V1H
Domain Architecture
Description	Vacuolar ATP synthase subunit H (EC 3.6.3.14) (V-ATPase H subunit) (Vacuolar proton pump subunit H) (V-ATPase 50/57 kDa subunits) (Vacuolar proton pump subunit SFD) (VMA13) (Nef-binding protein 1) (NBP1).

VATH_MOUSE
θ value	5.27518 (rank : 171)	NC score	0.024428 (rank : 307)
Query Neighborhood Hits	197	Target Neighborhood Hits	33	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BVE3, Q921X8	Gene names	Atp6v1h
Domain Architecture	No domain graphic available
Description	Vacuolar ATP synthase subunit H (EC 3.6.3.14) (V-ATPase H subunit) (Vacuolar proton pump subunit H).

ZO2_HUMAN
θ value	5.27518 (rank : 172)	NC score	0.077157 (rank : 189)
Query Neighborhood Hits	197	Target Neighborhood Hits	289	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

AP2C_HUMAN
θ value	6.88961 (rank : 173)	NC score	0.014301 (rank : 318)
Query Neighborhood Hits	197	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q92754, O00685, O00730, Q86V30, Q8IVB6, Q9P1X2	Gene names	TFAP2C
Domain Architecture
Description	Transcription factor AP-2 gamma (AP2-gamma) (Activating enhancer- binding protein 2 gamma) (Transcription factor ERF-1).

CEND3_MOUSE
θ value	6.88961 (rank : 174)	NC score	0.053050 (rank : 266)
Query Neighborhood Hits	197	Target Neighborhood Hits	228	Shared Neighborhood Hits	41
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

EPHA5_HUMAN
θ value	6.88961 (rank : 175)	NC score	0.004925 (rank : 328)
Query Neighborhood Hits	197	Target Neighborhood Hits	1009	Shared Neighborhood Hits	24
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHA7_HUMAN
θ value	6.88961 (rank : 176)	NC score	0.002879 (rank : 330)
Query Neighborhood Hits	197	Target Neighborhood Hits	1053	Shared Neighborhood Hits	24
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

FLNC_HUMAN
θ value	6.88961 (rank : 177)	NC score	0.011249 (rank : 320)
Query Neighborhood Hits	197	Target Neighborhood Hits	116	Shared Neighborhood Hits	7
SwissProt Accessions	Q14315, O95303, Q07985, Q9NS12, Q9NYE5, Q9UMR8, Q9Y503	Gene names	FLNC, ABPL, FLN2
Domain Architecture
Description	Filamin-C (Gamma-filamin) (Filamin-2) (Protein FLNc) (Actin-binding- like protein) (ABP-L) (ABP-280-like protein).

MLTK_MOUSE
θ value	6.88961 (rank : 178)	NC score	0.005029 (rank : 327)
Query Neighborhood Hits	197	Target Neighborhood Hits	874	Shared Neighborhood Hits	22
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

OSBL1_MOUSE
θ value	6.88961 (rank : 179)	NC score	0.026633 (rank : 302)
Query Neighborhood Hits	197	Target Neighborhood Hits	336	Shared Neighborhood Hits	19
SwissProt Accessions	Q91XL9, O88318, Q3TH97, Q673L8, Q6DFU6	Gene names	Osbpl1a, Orp1, Orp1a
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

PKHA2_HUMAN
θ value	6.88961 (rank : 180)	NC score	0.158357 (rank : 53)
Query Neighborhood Hits	197	Target Neighborhood Hits	119	Shared Neighborhood Hits	52
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHB2_MOUSE
θ value	6.88961 (rank : 181)	NC score	0.128945 (rank : 82)
Query Neighborhood Hits	197	Target Neighborhood Hits	48	Shared Neighborhood Hits	31
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

SNTG1_MOUSE
θ value	6.88961 (rank : 182)	NC score	0.117863 (rank : 90)
Query Neighborhood Hits	197	Target Neighborhood Hits	179	Shared Neighborhood Hits	49
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SPTB2_MOUSE
θ value	6.88961 (rank : 183)	NC score	0.025831 (rank : 305)
Query Neighborhood Hits	197	Target Neighborhood Hits	770	Shared Neighborhood Hits	41
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

TMPS9_MOUSE
θ value	6.88961 (rank : 184)	NC score	0.001619 (rank : 331)
Query Neighborhood Hits	197	Target Neighborhood Hits	296	Shared Neighborhood Hits	5
SwissProt Accessions	P69525	Gene names	Tmprss9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserine protease 1) (Polyserase-I) [Contains: Serase-1; Serase-2; Serase-3].

ASPP1_MOUSE
θ value	8.99809 (rank : 185)	NC score	0.023501 (rank : 309)
Query Neighborhood Hits	197	Target Neighborhood Hits	1244	Shared Neighborhood Hits	39
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

GOGB1_HUMAN
θ value	8.99809 (rank : 186)	NC score	0.025866 (rank : 304)
Query Neighborhood Hits	197	Target Neighborhood Hits	2297	Shared Neighborhood Hits	58
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

LIMK1_MOUSE
θ value	8.99809 (rank : 187)	NC score	0.003822 (rank : 329)
Query Neighborhood Hits	197	Target Neighborhood Hits	1008	Shared Neighborhood Hits	36
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

MPP5_HUMAN
θ value	8.99809 (rank : 188)	NC score	0.064412 (rank : 225)
Query Neighborhood Hits	197	Target Neighborhood Hits	231	Shared Neighborhood Hits	49
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	8.99809 (rank : 189)	NC score	0.063865 (rank : 226)
Query Neighborhood Hits	197	Target Neighborhood Hits	226	Shared Neighborhood Hits	49
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

MYH11_HUMAN
θ value	8.99809 (rank : 190)	NC score	0.028580 (rank : 299)
Query Neighborhood Hits	197	Target Neighborhood Hits	1806	Shared Neighborhood Hits	49
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH11_MOUSE
θ value	8.99809 (rank : 191)	NC score	0.027185 (rank : 301)
Query Neighborhood Hits	197	Target Neighborhood Hits	1777	Shared Neighborhood Hits	45
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

NUMA1_HUMAN
θ value	8.99809 (rank : 192)	NC score	0.022898 (rank : 310)
Query Neighborhood Hits	197	Target Neighborhood Hits	1523	Shared Neighborhood Hits	48
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

RBBP8_HUMAN
θ value	8.99809 (rank : 193)	NC score	0.020454 (rank : 314)
Query Neighborhood Hits	197	Target Neighborhood Hits	476	Shared Neighborhood Hits	21
SwissProt Accessions	Q99708, O75371	Gene names	RBBP8, CTIP
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 8 (RBBP-8) (CtBP-interacting protein) (CtIP) (Retinoblastoma-interacting protein and myosin-like) (RIM).

SDC2_MOUSE
θ value	8.99809 (rank : 194)	NC score	0.021201 (rank : 312)
Query Neighborhood Hits	197	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	P43407	Gene names	Sdc2, Hspg1, Synd2
Domain Architecture
Description	Syndecan-2 precursor (SYND2) (Fibroglycan) (Heparan sulfate proteoglycan core protein) (HSPG).

SOS2_HUMAN
θ value	8.99809 (rank : 195)	NC score	0.018912 (rank : 316)
Query Neighborhood Hits	197	Target Neighborhood Hits	193	Shared Neighborhood Hits	17
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

TGIF2_MOUSE
θ value	8.99809 (rank : 196)	NC score	0.010079 (rank : 322)
Query Neighborhood Hits	197	Target Neighborhood Hits	127	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C0Y1	Gene names	Tgif2
Domain Architecture	No domain graphic available
Description	Homeobox protein TGIF2 (TGFB-induced factor 2) (5'-TG-3'-interacting factor 2) (TGF(beta)-induced transcription factor 2).

ZO2_MOUSE
θ value	8.99809 (rank : 197)	NC score	0.072021 (rank : 209)
Query Neighborhood Hits	197	Target Neighborhood Hits	296	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

3BP2_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.105218 (rank : 104)
Query Neighborhood Hits	197	Target Neighborhood Hits	296	Shared Neighborhood Hits	35
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

3BP2_MOUSE
θ value	θ > 10 (rank : 199)	NC score	0.105088 (rank : 105)
Query Neighborhood Hits	197	Target Neighborhood Hits	142	Shared Neighborhood Hits	27
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

AFAD_HUMAN
θ value	θ > 10 (rank : 200)	NC score	0.085808 (rank : 153)
Query Neighborhood Hits	197	Target Neighborhood Hits	689	Shared Neighborhood Hits	67
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

ANLN_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.083656 (rank : 165)
Query Neighborhood Hits	197	Target Neighborhood Hits	222	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NQW6, Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0	Gene names	ANLN
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

ANLN_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.069452 (rank : 216)
Query Neighborhood Hits	197	Target Neighborhood Hits	297	Shared Neighborhood Hits	28
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

APBA1_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.096852 (rank : 120)
Query Neighborhood Hits	197	Target Neighborhood Hits	325	Shared Neighborhood Hits	53
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

APBA2_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.082978 (rank : 170)
Query Neighborhood Hits	197	Target Neighborhood Hits	220	Shared Neighborhood Hits	46
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_MOUSE
θ value	θ > 10 (rank : 205)	NC score	0.083215 (rank : 168)
Query Neighborhood Hits	197	Target Neighborhood Hits	219	Shared Neighborhood Hits	45
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APXL_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.054702 (rank : 257)
Query Neighborhood Hits	197	Target Neighborhood Hits	553	Shared Neighborhood Hits	42
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

ARHGB_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.067264 (rank : 219)
Query Neighborhood Hits	197	Target Neighborhood Hits	375	Shared Neighborhood Hits	57
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.064840 (rank : 223)
Query Neighborhood Hits	197	Target Neighborhood Hits	351	Shared Neighborhood Hits	64
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.062895 (rank : 230)
Query Neighborhood Hits	197	Target Neighborhood Hits	344	Shared Neighborhood Hits	62
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

BIG1_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.096247 (rank : 122)
Query Neighborhood Hits	197	Target Neighborhood Hits	76	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

BIG2_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.096743 (rank : 121)
Query Neighborhood Hits	197	Target Neighborhood Hits	66	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

C43BP_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.057597 (rank : 250)
Query Neighborhood Hits	197	Target Neighborhood Hits	87	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

C43BP_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.059789 (rank : 241)
Query Neighborhood Hits	197	Target Neighborhood Hits	91	Shared Neighborhood Hits	38
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

CENB1_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.059734 (rank : 242)
Query Neighborhood Hits	197	Target Neighborhood Hits	383	Shared Neighborhood Hits	48
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

CENB2_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.075372 (rank : 193)
Query Neighborhood Hits	197	Target Neighborhood Hits	425	Shared Neighborhood Hits	53
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENB5_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.072362 (rank : 207)
Query Neighborhood Hits	197	Target Neighborhood Hits	395	Shared Neighborhood Hits	51
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CEND1_MOUSE
θ value	θ > 10 (rank : 217)	NC score	0.052436 (rank : 268)
Query Neighborhood Hits	197	Target Neighborhood Hits	260	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CEND2_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.057205 (rank : 251)
Query Neighborhood Hits	197	Target Neighborhood Hits	166	Shared Neighborhood Hits	39
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

DAPP1_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.108158 (rank : 98)
Query Neighborhood Hits	197	Target Neighborhood Hits	227	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.113037 (rank : 94)
Query Neighborhood Hits	197	Target Neighborhood Hits	225	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DLG1_MOUSE
θ value	θ > 10 (rank : 221)	NC score	0.083749 (rank : 164)
Query Neighborhood Hits	197	Target Neighborhood Hits	285	Shared Neighborhood Hits	48
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

DLG2_HUMAN
θ value	θ > 10 (rank : 222)	NC score	0.086429 (rank : 150)
Query Neighborhood Hits	197	Target Neighborhood Hits	279	Shared Neighborhood Hits	51
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG2_MOUSE
θ value	θ > 10 (rank : 223)	NC score	0.085769 (rank : 154)
Query Neighborhood Hits	197	Target Neighborhood Hits	271	Shared Neighborhood Hits	50
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG3_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.086035 (rank : 152)
Query Neighborhood Hits	197	Target Neighborhood Hits	269	Shared Neighborhood Hits	53
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG3_MOUSE
θ value	θ > 10 (rank : 225)	NC score	0.087307 (rank : 149)
Query Neighborhood Hits	197	Target Neighborhood Hits	274	Shared Neighborhood Hits	53
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

DLG4_HUMAN
θ value	θ > 10 (rank : 226)	NC score	0.084709 (rank : 157)
Query Neighborhood Hits	197	Target Neighborhood Hits	286	Shared Neighborhood Hits	50
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_MOUSE
θ value	θ > 10 (rank : 227)	NC score	0.084928 (rank : 156)
Query Neighborhood Hits	197	Target Neighborhood Hits	282	Shared Neighborhood Hits	51
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG5_HUMAN
θ value	θ > 10 (rank : 228)	NC score	0.061666 (rank : 233)
Query Neighborhood Hits	197	Target Neighborhood Hits	1088	Shared Neighborhood Hits	81
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

DNM1L_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.061354 (rank : 235)
Query Neighborhood Hits	197	Target Neighborhood Hits	39	Shared Neighborhood Hits	5
SwissProt Accessions	O00429, O14541, O60709, Q7L6B3, Q8TBT7, Q9BWM1, Q9Y5J2	Gene names	DNM1L, DLP1, DRP1
Domain Architecture	No domain graphic available
Description	Dynamin-1-like protein (EC 3.6.5.5) (Dynamin-like protein) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-related protein 1) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV).

DNM1L_MOUSE
θ value	θ > 10 (rank : 230)	NC score	0.061385 (rank : 234)
Query Neighborhood Hits	197	Target Neighborhood Hits	28	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K1M6, Q8BNQ5, Q8BQ64, Q8CGD0, Q8K1A1	Gene names	Dnm1l, Drp1
Domain Architecture	No domain graphic available
Description	Dynamin-1-like protein (EC 3.6.5.5) (Dynamin-related protein 1) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple).

DVL1_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.050807 (rank : 271)
Query Neighborhood Hits	197	Target Neighborhood Hits	158	Shared Neighborhood Hits	43
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL3_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.052346 (rank : 269)
Query Neighborhood Hits	197	Target Neighborhood Hits	194	Shared Neighborhood Hits	39
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_MOUSE
θ value	θ > 10 (rank : 233)	NC score	0.053669 (rank : 262)
Query Neighborhood Hits	197	Target Neighborhood Hits	198	Shared Neighborhood Hits	43
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

FBX8_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.089149 (rank : 141)
Query Neighborhood Hits	197	Target Neighborhood Hits	44	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NRD0, Q6UWN4, Q9NRP5, Q9UKC4	Gene names	FBXO8, FBS, FBX8
Domain Architecture
Description	F-box only protein 8 (F-box/SEC7 protein FBS).

FBX8_MOUSE
θ value	θ > 10 (rank : 235)	NC score	0.089503 (rank : 138)
Query Neighborhood Hits	197	Target Neighborhood Hits	45	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QZN3	Gene names	Fbxo8, Fbx8
Domain Architecture
Description	F-box only protein 8.

FGD1_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.073614 (rank : 201)
Query Neighborhood Hits	197	Target Neighborhood Hits	367	Shared Neighborhood Hits	34
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	θ > 10 (rank : 237)	NC score	0.073086 (rank : 203)
Query Neighborhood Hits	197	Target Neighborhood Hits	387	Shared Neighborhood Hits	35
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.054900 (rank : 256)
Query Neighborhood Hits	197	Target Neighborhood Hits	151	Shared Neighborhood Hits	21
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	θ > 10 (rank : 239)	NC score	0.059711 (rank : 243)
Query Neighborhood Hits	197	Target Neighborhood Hits	163	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_MOUSE
θ value	θ > 10 (rank : 240)	NC score	0.056482 (rank : 253)
Query Neighborhood Hits	197	Target Neighborhood Hits	257	Shared Neighborhood Hits	26
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD4_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.062774 (rank : 231)
Query Neighborhood Hits	197	Target Neighborhood Hits	219	Shared Neighborhood Hits	30
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	θ > 10 (rank : 242)	NC score	0.060032 (rank : 240)
Query Neighborhood Hits	197	Target Neighborhood Hits	227	Shared Neighborhood Hits	30
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

GBF1_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.098038 (rank : 117)
Query Neighborhood Hits	197	Target Neighborhood Hits	142	Shared Neighborhood Hits	12
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

GNRP_MOUSE
θ value	θ > 10 (rank : 244)	NC score	0.073095 (rank : 202)
Query Neighborhood Hits	197	Target Neighborhood Hits	191	Shared Neighborhood Hits	36
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GRASP_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.074340 (rank : 197)
Query Neighborhood Hits	197	Target Neighborhood Hits	147	Shared Neighborhood Hits	34
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

GRASP_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.071905 (rank : 211)
Query Neighborhood Hits	197	Target Neighborhood Hits	131	Shared Neighborhood Hits	33
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

IL16_MOUSE
θ value	θ > 10 (rank : 247)	NC score	0.112420 (rank : 96)
Query Neighborhood Hits	197	Target Neighborhood Hits	189	Shared Neighborhood Hits	40
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

IQEC1_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.085481 (rank : 155)
Query Neighborhood Hits	197	Target Neighborhood Hits	76	Shared Neighborhood Hits	14
SwissProt Accessions	Q6DN90, O94863, Q96D85	Gene names	IQSEC1, ARFGEP100, BRAG2, KIAA0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein).

IQEC1_MOUSE
θ value	θ > 10 (rank : 249)	NC score	0.083784 (rank : 163)
Query Neighborhood Hits	197	Target Neighborhood Hits	54	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R0S2, Q3TZC3, Q5DU15	Gene names	Iqsec1, Kiaa0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1.

IQEC2_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.078710 (rank : 178)
Query Neighborhood Hits	197	Target Neighborhood Hits	403	Shared Neighborhood Hits	24
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC2_MOUSE
θ value	θ > 10 (rank : 251)	NC score	0.079715 (rank : 175)
Query Neighborhood Hits	197	Target Neighborhood Hits	417	Shared Neighborhood Hits	25
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC3_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.090928 (rank : 131)
Query Neighborhood Hits	197	Target Neighborhood Hits	125	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

IQEC3_MOUSE
θ value	θ > 10 (rank : 253)	NC score	0.092884 (rank : 127)
Query Neighborhood Hits	197	Target Neighborhood Hits	274	Shared Neighborhood Hits	22
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

K1849_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.088475 (rank : 142)
Query Neighborhood Hits	197	Target Neighborhood Hits	220	Shared Neighborhood Hits	45
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

K1849_MOUSE
θ value	θ > 10 (rank : 255)	NC score	0.086179 (rank : 151)
Query Neighborhood Hits	197	Target Neighborhood Hits	335	Shared Neighborhood Hits	53
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

LAP4_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.065025 (rank : 222)
Query Neighborhood Hits	197	Target Neighborhood Hits	608	Shared Neighborhood Hits	58
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

LAP4_MOUSE
θ value	θ > 10 (rank : 257)	NC score	0.064597 (rank : 224)
Query Neighborhood Hits	197	Target Neighborhood Hits	590	Shared Neighborhood Hits	56
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

LIPB2_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.058616 (rank : 244)
Query Neighborhood Hits	197	Target Neighborhood Hits	599	Shared Neighborhood Hits	41
SwissProt Accessions	Q8ND30, O75337, Q8WW26	Gene names	PPFIBP2
Domain Architecture
Description	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2).

LNX1_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.104377 (rank : 108)
Query Neighborhood Hits	197	Target Neighborhood Hits	379	Shared Neighborhood Hits	53
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

LNX1_MOUSE
θ value	θ > 10 (rank : 260)	NC score	0.103471 (rank : 112)
Query Neighborhood Hits	197	Target Neighborhood Hits	377	Shared Neighborhood Hits	56
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

LNX2_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.099952 (rank : 115)
Query Neighborhood Hits	197	Target Neighborhood Hits	389	Shared Neighborhood Hits	52
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

LNX2_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.097686 (rank : 119)
Query Neighborhood Hits	197	Target Neighborhood Hits	407	Shared Neighborhood Hits	55
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

MPP4_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.068613 (rank : 218)
Query Neighborhood Hits	197	Target Neighborhood Hits	205	Shared Neighborhood Hits	45
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

MPP4_MOUSE
θ value	θ > 10 (rank : 264)	NC score	0.063316 (rank : 228)
Query Neighborhood Hits	197	Target Neighborhood Hits	188	Shared Neighborhood Hits	46
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

MTMRD_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.056514 (rank : 252)
Query Neighborhood Hits	197	Target Neighborhood Hits	135	Shared Neighborhood Hits	39
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

NEB2_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.089321 (rank : 139)
Query Neighborhood Hits	197	Target Neighborhood Hits	883	Shared Neighborhood Hits	71
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEB2_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.088363 (rank : 143)
Query Neighborhood Hits	197	Target Neighborhood Hits	889	Shared Neighborhood Hits	72
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NHERF_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.083186 (rank : 169)
Query Neighborhood Hits	197	Target Neighborhood Hits	190	Shared Neighborhood Hits	42
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHERF_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.091365 (rank : 129)
Query Neighborhood Hits	197	Target Neighborhood Hits	195	Shared Neighborhood Hits	43
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHRF2_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.091295 (rank : 130)
Query Neighborhood Hits	197	Target Neighborhood Hits	197	Shared Neighborhood Hits	49
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

NHRF2_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.088260 (rank : 144)
Query Neighborhood Hits	197	Target Neighborhood Hits	194	Shared Neighborhood Hits	49
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

OSBP1_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.069166 (rank : 217)
Query Neighborhood Hits	197	Target Neighborhood Hits	180	Shared Neighborhood Hits	49
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

PAR3L_HUMAN
θ value	θ > 10 (rank : 273)	NC score	0.099000 (rank : 116)
Query Neighborhood Hits	197	Target Neighborhood Hits	297	Shared Neighborhood Hits	48
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

PAR6A_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.053627 (rank : 263)
Query Neighborhood Hits	197	Target Neighborhood Hits	119	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

PAR6A_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.053120 (rank : 265)
Query Neighborhood Hits	197	Target Neighborhood Hits	115	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

PAR6G_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.052100 (rank : 270)
Query Neighborhood Hits	197	Target Neighborhood Hits	159	Shared Neighborhood Hits	41
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

PAR6G_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.053781 (rank : 261)
Query Neighborhood Hits	197	Target Neighborhood Hits	121	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

PARD3_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.105739 (rank : 103)
Query Neighborhood Hits	197	Target Neighborhood Hits	312	Shared Neighborhood Hits	54
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

PARD3_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.104515 (rank : 107)
Query Neighborhood Hits	197	Target Neighborhood Hits	290	Shared Neighborhood Hits	54
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

PDLI2_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.062289 (rank : 232)
Query Neighborhood Hits	197	Target Neighborhood Hits	245	Shared Neighborhood Hits	34
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

PDLI2_MOUSE
θ value	θ > 10 (rank : 281)	NC score	0.058358 (rank : 246)
Query Neighborhood Hits	197	Target Neighborhood Hits	220	Shared Neighborhood Hits	36
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

PDZ11_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.090632 (rank : 133)
Query Neighborhood Hits	197	Target Neighborhood Hits	160	Shared Neighborhood Hits	39
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZ11_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.088186 (rank : 145)
Query Neighborhood Hits	197	Target Neighborhood Hits	154	Shared Neighborhood Hits	36
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZD1_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.089517 (rank : 137)
Query Neighborhood Hits	197	Target Neighborhood Hits	190	Shared Neighborhood Hits	45
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PDZD1_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.092216 (rank : 128)
Query Neighborhood Hits	197	Target Neighborhood Hits	191	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PDZD3_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.079758 (rank : 174)
Query Neighborhood Hits	197	Target Neighborhood Hits	180	Shared Neighborhood Hits	45
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

PDZD3_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.078155 (rank : 184)
Query Neighborhood Hits	197	Target Neighborhood Hits	171	Shared Neighborhood Hits	46
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

PDZD7_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.106353 (rank : 102)
Query Neighborhood Hits	197	Target Neighborhood Hits	181	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

PDZK4_HUMAN
θ value	θ > 10 (rank : 289)	NC score	0.052476 (rank : 267)
Query Neighborhood Hits	197	Target Neighborhood Hits	165	Shared Neighborhood Hits	38
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PDZK4_MOUSE
θ value	θ > 10 (rank : 290)	NC score	0.054221 (rank : 260)
Query Neighborhood Hits	197	Target Neighborhood Hits	165	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PHLB2_HUMAN
θ value	θ > 10 (rank : 291)	NC score	0.058289 (rank : 247)
Query Neighborhood Hits	197	Target Neighborhood Hits	964	Shared Neighborhood Hits	56
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PHLB2_MOUSE
θ value	θ > 10 (rank : 292)	NC score	0.060642 (rank : 238)
Query Neighborhood Hits	197	Target Neighborhood Hits	1016	Shared Neighborhood Hits	56
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PICK1_HUMAN
θ value	θ > 10 (rank : 293)	NC score	0.077619 (rank : 188)
Query Neighborhood Hits	197	Target Neighborhood Hits	132	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PICK1_MOUSE
θ value	θ > 10 (rank : 294)	NC score	0.078571 (rank : 180)
Query Neighborhood Hits	197	Target Neighborhood Hits	131	Shared Neighborhood Hits	44
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PKHA1_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.162393 (rank : 49)
Query Neighborhood Hits	197	Target Neighborhood Hits	127	Shared Neighborhood Hits	50
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	θ > 10 (rank : 296)	NC score	0.163122 (rank : 48)
Query Neighborhood Hits	197	Target Neighborhood Hits	120	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PLEK2_HUMAN
θ value	θ > 10 (rank : 297)	NC score	0.106570 (rank : 101)
Query Neighborhood Hits	197	Target Neighborhood Hits	101	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_MOUSE
θ value	θ > 10 (rank : 298)	NC score	0.103729 (rank : 110)
Query Neighborhood Hits	197	Target Neighborhood Hits	96	Shared Neighborhood Hits	42
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PSCBP_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.074538 (rank : 195)
Query Neighborhood Hits	197	Target Neighborhood Hits	123	Shared Neighborhood Hits	33
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

PSCBP_MOUSE
θ value	θ > 10 (rank : 300)	NC score	0.075387 (rank : 192)
Query Neighborhood Hits	197	Target Neighborhood Hits	118	Shared Neighborhood Hits	33
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

PSD4_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.123661 (rank : 89)
Query Neighborhood Hits	197	Target Neighborhood Hits	178	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

PSD4_MOUSE
θ value	θ > 10 (rank : 302)	NC score	0.112929 (rank : 95)
Query Neighborhood Hits	197	Target Neighborhood Hits	78	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

PZRN3_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.074491 (rank : 196)
Query Neighborhood Hits	197	Target Neighborhood Hits	461	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PZRN3_MOUSE
θ value	θ > 10 (rank : 304)	NC score	0.075369 (rank : 194)
Query Neighborhood Hits	197	Target Neighborhood Hits	447	Shared Neighborhood Hits	49
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

RASA1_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.056410 (rank : 254)
Query Neighborhood Hits	197	Target Neighborhood Hits	258	Shared Neighborhood Hits	32
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RHPN1_MOUSE
θ value	θ > 10 (rank : 306)	NC score	0.058041 (rank : 249)
Query Neighborhood Hits	197	Target Neighborhood Hits	154	Shared Neighborhood Hits	39
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

SAV1_HUMAN
θ value	θ > 10 (rank : 307)	NC score	0.060748 (rank : 236)
Query Neighborhood Hits	197	Target Neighborhood Hits	51	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
θ value	θ > 10 (rank : 308)	NC score	0.060549 (rank : 239)
Query Neighborhood Hits	197	Target Neighborhood Hits	48	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

SDCB2_HUMAN
θ value	θ > 10 (rank : 309)	NC score	0.053599 (rank : 264)
Query Neighborhood Hits	197	Target Neighborhood Hits	121	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

SDCB2_MOUSE
θ value	θ > 10 (rank : 310)	NC score	0.058580 (rank : 245)
Query Neighborhood Hits	197	Target Neighborhood Hits	118	Shared Neighborhood Hits	41
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

SNTA1_HUMAN
θ value	θ > 10 (rank : 311)	NC score	0.093742 (rank : 125)
Query Neighborhood Hits	197	Target Neighborhood Hits	186	Shared Neighborhood Hits	52
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

SNTA1_MOUSE
θ value	θ > 10 (rank : 312)	NC score	0.089293 (rank : 140)
Query Neighborhood Hits	197	Target Neighborhood Hits	170	Shared Neighborhood Hits	47
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

SNTB1_HUMAN
θ value	θ > 10 (rank : 313)	NC score	0.084152 (rank : 162)
Query Neighborhood Hits	197	Target Neighborhood Hits	157	Shared Neighborhood Hits	45
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

SNTB1_MOUSE
θ value	θ > 10 (rank : 314)	NC score	0.084187 (rank : 161)
Query Neighborhood Hits	197	Target Neighborhood Hits	160	Shared Neighborhood Hits	46
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

SNTB2_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.087849 (rank : 147)
Query Neighborhood Hits	197	Target Neighborhood Hits	180	Shared Neighborhood Hits	48
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

SNTB2_MOUSE
θ value	θ > 10 (rank : 316)	NC score	0.087484 (rank : 148)
Query Neighborhood Hits	197	Target Neighborhood Hits	181	Shared Neighborhood Hits	48
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

STXB4_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.077970 (rank : 185)
Query Neighborhood Hits	197	Target Neighborhood Hits	616	Shared Neighborhood Hits	54
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_MOUSE
θ value	θ > 10 (rank : 318)	NC score	0.074076 (rank : 200)
Query Neighborhood Hits	197	Target Neighborhood Hits	629	Shared Neighborhood Hits	55
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

SYJ2B_HUMAN
θ value	θ > 10 (rank : 319)	NC score	0.104996 (rank : 106)
Query Neighborhood Hits	197	Target Neighborhood Hits	162	Shared Neighborhood Hits	39
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

SYP2L_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.058263 (rank : 248)
Query Neighborhood Hits	197	Target Neighborhood Hits	400	Shared Neighborhood Hits	39
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

TX1B3_HUMAN
θ value	θ > 10 (rank : 321)	NC score	0.078682 (rank : 179)
Query Neighborhood Hits	197	Target Neighborhood Hits	161	Shared Neighborhood Hits	42
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
θ value	θ > 10 (rank : 322)	NC score	0.078172 (rank : 183)
Query Neighborhood Hits	197	Target Neighborhood Hits	158	Shared Neighborhood Hits	42
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

USH1C_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.097914 (rank : 118)
Query Neighborhood Hits	197	Target Neighborhood Hits	327	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

USH1C_MOUSE
θ value	θ > 10 (rank : 324)	NC score	0.089852 (rank : 136)
Query Neighborhood Hits	197	Target Neighborhood Hits	557	Shared Neighborhood Hits	62
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

WHRN_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.094865 (rank : 124)
Query Neighborhood Hits	197	Target Neighborhood Hits	325	Shared Neighborhood Hits	57
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

WHRN_MOUSE
θ value	θ > 10 (rank : 326)	NC score	0.093724 (rank : 126)
Query Neighborhood Hits	197	Target Neighborhood Hits	412	Shared Neighborhood Hits	57
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

WWC1_HUMAN
θ value	θ > 10 (rank : 327)	NC score	0.050638 (rank : 272)
Query Neighborhood Hits	197	Target Neighborhood Hits	290	Shared Neighborhood Hits	15
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

ZO1_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.071975 (rank : 210)
Query Neighborhood Hits	197	Target Neighborhood Hits	474	Shared Neighborhood Hits	53
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZO1_MOUSE
θ value	θ > 10 (rank : 329)	NC score	0.072789 (rank : 205)
Query Neighborhood Hits	197	Target Neighborhood Hits	453	Shared Neighborhood Hits	53
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZO3_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.078445 (rank : 181)
Query Neighborhood Hits	197	Target Neighborhood Hits	219	Shared Neighborhood Hits	46
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

ZO3_MOUSE
θ value	θ > 10 (rank : 331)	NC score	0.077741 (rank : 187)
Query Neighborhood Hits	197	Target Neighborhood Hits	224	Shared Neighborhood Hits	48
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

Hits sorted by NC score

CNKR2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	197	Target Neighborhood Hits	197	Shared Neighborhood Hits	197
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.998533 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	197	Target Neighborhood Hits	197	Shared Neighborhood Hits	189
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR1_HUMAN
NC score	0.751612 (rank : 3)	θ value	5.95217e-44 (rank : 3)
Query Neighborhood Hits	197	Target Neighborhood Hits	154	Shared Neighborhood Hits	64
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

PKHA4_MOUSE
NC score	0.441076 (rank : 4)	θ value	2.61198e-07 (rank : 10)
Query Neighborhood Hits	197	Target Neighborhood Hits	202	Shared Neighborhood Hits	54
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA5_HUMAN
NC score	0.433733 (rank : 5)	θ value	4.91457e-14 (rank : 4)
Query Neighborhood Hits	197	Target Neighborhood Hits	455	Shared Neighborhood Hits	71
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA4_HUMAN
NC score	0.422472 (rank : 6)	θ value	2.61198e-07 (rank : 9)
Query Neighborhood Hits	197	Target Neighborhood Hits	283	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA6_HUMAN
NC score	0.422246 (rank : 7)	θ value	7.84624e-12 (rank : 5)
Query Neighborhood Hits	197	Target Neighborhood Hits	556	Shared Neighborhood Hits	72
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
NC score	0.402354 (rank : 8)	θ value	4.30538e-10 (rank : 6)
Query Neighborhood Hits	197	Target Neighborhood Hits	591	Shared Neighborhood Hits	73
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

CYH3_HUMAN
NC score	0.265535 (rank : 9)	θ value	0.00020696 (rank : 19)
Query Neighborhood Hits	197	Target Neighborhood Hits	137	Shared Neighborhood Hits	59
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

CYH4_HUMAN
NC score	0.263260 (rank : 10)	θ value	9.29e-05 (rank : 15)
Query Neighborhood Hits	197	Target Neighborhood Hits	135	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

CYH2_HUMAN
NC score	0.261987 (rank : 11)	θ value	0.000121331 (rank : 16)
Query Neighborhood Hits	197	Target Neighborhood Hits	175	Shared Neighborhood Hits	60
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
NC score	0.261970 (rank : 12)	θ value	0.000121331 (rank : 17)
Query Neighborhood Hits	197	Target Neighborhood Hits	171	Shared Neighborhood Hits	60
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH3_MOUSE
NC score	0.259894 (rank : 13)	θ value	0.000602161 (rank : 25)
Query Neighborhood Hits	197	Target Neighborhood Hits	148	Shared Neighborhood Hits	62
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

CYH4_MOUSE
NC score	0.259650 (rank : 14)	θ value	0.000461057 (rank : 22)
Query Neighborhood Hits	197	Target Neighborhood Hits	134	Shared Neighborhood Hits	62
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

CYH1_HUMAN
NC score	0.258985 (rank : 15)	θ value	0.00102713 (rank : 29)
Query Neighborhood Hits	197	Target Neighborhood Hits	184	Shared Neighborhood Hits	63
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
NC score	0.258540 (rank : 16)	θ value	0.00102713 (rank : 30)
Query Neighborhood Hits	197	Target Neighborhood Hits	176	Shared Neighborhood Hits	63
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

MAGI2_HUMAN
NC score	0.254034 (rank : 17)	θ value	1.38499e-08 (rank : 7)
Query Neighborhood Hits	197	Target Neighborhood Hits	373	Shared Neighborhood Hits	59
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MAGI2_MOUSE
NC score	0.250805 (rank : 18)	θ value	3.08544e-08 (rank : 8)
Query Neighborhood Hits	197	Target Neighborhood Hits	370	Shared Neighborhood Hits	58
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

GAB2_MOUSE
NC score	0.247861 (rank : 19)	θ value	1.43324e-05 (rank : 13)
Query Neighborhood Hits	197	Target Neighborhood Hits	220	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

SHAN2_HUMAN
NC score	0.241526 (rank : 20)	θ value	0.000461057 (rank : 24)
Query Neighborhood Hits	197	Target Neighborhood Hits	346	Shared Neighborhood Hits	75
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

GAB2_HUMAN
NC score	0.240909 (rank : 21)	θ value	0.000121331 (rank : 18)
Query Neighborhood Hits	197	Target Neighborhood Hits	188	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

SAM14_HUMAN
NC score	0.239553 (rank : 22)	θ value	0.00134147 (rank : 33)
Query Neighborhood Hits	197	Target Neighborhood Hits	81	Shared Neighborhood Hits	22
SwissProt Accessions	Q8IZD0, Q8N2X0	Gene names	SAMD14
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 14.

SHAN2_MOUSE
NC score	0.227423 (rank : 23)	θ value	0.000270298 (rank : 20)
Query Neighborhood Hits	197	Target Neighborhood Hits	446	Shared Neighborhood Hits	73
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

GAB1_MOUSE
NC score	0.223244 (rank : 24)	θ value	0.000786445 (rank : 28)
Query Neighborhood Hits	197	Target Neighborhood Hits	233	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

PLEK_HUMAN
NC score	0.222051 (rank : 25)	θ value	0.0431538 (rank : 59)
Query Neighborhood Hits	197	Target Neighborhood Hits	110	Shared Neighborhood Hits	54
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

GAB1_HUMAN
NC score	0.219142 (rank : 26)	θ value	0.00298849 (rank : 39)
Query Neighborhood Hits	197	Target Neighborhood Hits	279	Shared Neighborhood Hits	37
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

SAM14_MOUSE
NC score	0.218514 (rank : 27)	θ value	0.00869519 (rank : 48)
Query Neighborhood Hits	197	Target Neighborhood Hits	91	Shared Neighborhood Hits	25
SwissProt Accessions	Q8K070, Q5SWB7, Q8BHE2, Q8C8N5	Gene names	Samd14
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 14.

SARM1_MOUSE
NC score	0.210873 (rank : 28)	θ value	0.000461057 (rank : 23)
Query Neighborhood Hits	197	Target Neighborhood Hits	54	Shared Neighborhood Hits	25
SwissProt Accessions	Q6PDS3, Q5SYG5, Q5SYG6, Q6A054, Q6SZW0, Q8BRI9	Gene names	Sarm1, Kiaa0524
Domain Architecture	No domain graphic available
Description	Sterile alpha and TIR motif-containing protein 1 (Tir-1 homolog).

MAGI1_HUMAN
NC score	0.206742 (rank : 29)	θ value	0.00509761 (rank : 44)
Query Neighborhood Hits	197	Target Neighborhood Hits	388	Shared Neighborhood Hits	65
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI1_MOUSE
NC score	0.206241 (rank : 30)	θ value	0.00175202 (rank : 36)
Query Neighborhood Hits	197	Target Neighborhood Hits	403	Shared Neighborhood Hits	61
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

DGKH_HUMAN
NC score	0.202763 (rank : 31)	θ value	1.09739e-05 (rank : 12)
Query Neighborhood Hits	197	Target Neighborhood Hits	255	Shared Neighborhood Hits	72
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

PLEK_MOUSE
NC score	0.198870 (rank : 32)	θ value	0.21417 (rank : 82)
Query Neighborhood Hits	197	Target Neighborhood Hits	109	Shared Neighborhood Hits	47
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

SARM1_HUMAN
NC score	0.196338 (rank : 33)	θ value	0.00134147 (rank : 34)
Query Neighborhood Hits	197	Target Neighborhood Hits	58	Shared Neighborhood Hits	25
SwissProt Accessions	Q6SZW1, O60277, Q7LGG3, Q9NXY5	Gene names	SARM1, KIAA0524, SARM
Domain Architecture	No domain graphic available
Description	Sterile alpha and TIR motif-containing protein 1 (Sterile alpha and Armadillo repeat protein) (Tir-1 homolog).

MRIP_MOUSE
NC score	0.190893 (rank : 34)	θ value	0.000602161 (rank : 27)
Query Neighborhood Hits	197	Target Neighborhood Hits	569	Shared Neighborhood Hits	61
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

MPDZ_HUMAN
NC score	0.182331 (rank : 35)	θ value	0.000602161 (rank : 26)
Query Neighborhood Hits	197	Target Neighborhood Hits	261	Shared Neighborhood Hits	58
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

GRIP1_HUMAN
NC score	0.182209 (rank : 36)	θ value	0.00509761 (rank : 42)
Query Neighborhood Hits	197	Target Neighborhood Hits	231	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

GRIP2_HUMAN
NC score	0.181558 (rank : 37)	θ value	0.0252991 (rank : 52)
Query Neighborhood Hits	197	Target Neighborhood Hits	256	Shared Neighborhood Hits	58
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

MRIP_HUMAN
NC score	0.181418 (rank : 38)	θ value	0.00509761 (rank : 45)
Query Neighborhood Hits	197	Target Neighborhood Hits	578	Shared Neighborhood Hits	62
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

GRIP1_MOUSE
NC score	0.180902 (rank : 39)	θ value	0.00509761 (rank : 43)
Query Neighborhood Hits	197	Target Neighborhood Hits	241	Shared Neighborhood Hits	57
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

DGKD_HUMAN
NC score	0.174406 (rank : 40)	θ value	1.09739e-05 (rank : 11)
Query Neighborhood Hits	197	Target Neighborhood Hits	231	Shared Neighborhood Hits	49
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

MPDZ_MOUSE
NC score	0.173039 (rank : 41)	θ value	0.00175202 (rank : 37)
Query Neighborhood Hits	197	Target Neighborhood Hits	298	Shared Neighborhood Hits	55
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

RHG25_HUMAN
NC score	0.172830 (rank : 42)	θ value	0.0148317 (rank : 51)
Query Neighborhood Hits	197	Target Neighborhood Hits	550	Shared Neighborhood Hits	73
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_MOUSE
NC score	0.170219 (rank : 43)	θ value	0.0113563 (rank : 50)
Query Neighborhood Hits	197	Target Neighborhood Hits	492	Shared Neighborhood Hits	75
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

NEB1_HUMAN
NC score	0.168699 (rank : 44)	θ value	0.00134147 (rank : 32)
Query Neighborhood Hits	197	Target Neighborhood Hits	829	Shared Neighborhood Hits	80
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

PKHA2_MOUSE
NC score	0.167753 (rank : 45)	θ value	5.27518 (rank : 164)
Query Neighborhood Hits	197	Target Neighborhood Hits	116	Shared Neighborhood Hits	53
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

GIPC1_MOUSE
NC score	0.164035 (rank : 46)	θ value	0.0563607 (rank : 61)
Query Neighborhood Hits	197	Target Neighborhood Hits	92	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Z0G0	Gene names	Gipc1, Gipc, Rgs19ip1, Semcap1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Synectin) (SemaF cytoplasmic domain-associated protein 1) (SEMCAP-1).

FGD5_MOUSE
NC score	0.163217 (rank : 47)	θ value	0.00134147 (rank : 31)
Query Neighborhood Hits	197	Target Neighborhood Hits	170	Shared Neighborhood Hits	33
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

PKHA1_MOUSE
NC score	0.163122 (rank : 48)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	197	Target Neighborhood Hits	120	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_HUMAN
NC score	0.162393 (rank : 49)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	197	Target Neighborhood Hits	127	Shared Neighborhood Hits	50
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PSD3_HUMAN
NC score	0.161410 (rank : 50)	θ value	0.813845 (rank : 110)
Query Neighborhood Hits	197	Target Neighborhood Hits	75	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

INADL_HUMAN
NC score	0.160156 (rank : 51)	θ value	0.0736092 (rank : 67)
Query Neighborhood Hits	197	Target Neighborhood Hits	260	Shared Neighborhood Hits	57
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

INADL_MOUSE
NC score	0.159753 (rank : 52)	θ value	0.0736092 (rank : 68)
Query Neighborhood Hits	197	Target Neighborhood Hits	290	Shared Neighborhood Hits	59
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

PKHA2_HUMAN
NC score	0.158357 (rank : 53)	θ value	6.88961 (rank : 180)
Query Neighborhood Hits	197	Target Neighborhood Hits	119	Shared Neighborhood Hits	52
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

DYN2_MOUSE
NC score	0.157296 (rank : 54)	θ value	0.00390308 (rank : 41)
Query Neighborhood Hits	197	Target Neighborhood Hits	104	Shared Neighborhood Hits	36
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

FGD5_HUMAN
NC score	0.157230 (rank : 55)	θ value	0.00175202 (rank : 35)
Query Neighborhood Hits	197	Target Neighborhood Hits	235	Shared Neighborhood Hits	31
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

DYN2_HUMAN
NC score	0.157120 (rank : 56)	θ value	0.00390308 (rank : 40)
Query Neighborhood Hits	197	Target Neighborhood Hits	112	Shared Neighborhood Hits	36
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

SAM10_HUMAN
NC score	0.156005 (rank : 57)	θ value	0.0961366 (rank : 71)
Query Neighborhood Hits	197	Target Neighborhood Hits	20	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BYL1	Gene names	SAMD10, C20orf136
Domain Architecture
Description	Sterile alpha motif domain-containing protein 10.

GIPC1_HUMAN
NC score	0.154606 (rank : 58)	θ value	0.21417 (rank : 79)
Query Neighborhood Hits	197	Target Neighborhood Hits	91	Shared Neighborhood Hits	46
SwissProt Accessions	O14908, Q9BTC9	Gene names	GIPC1, C19orf3, GIPC, RGS19IP1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Tax interaction protein 2) (TIP-2).

IL16_HUMAN
NC score	0.154255 (rank : 59)	θ value	0.0736092 (rank : 66)
Query Neighborhood Hits	197	Target Neighborhood Hits	207	Shared Neighborhood Hits	44
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

GOPC_MOUSE
NC score	0.153451 (rank : 60)	θ value	0.279714 (rank : 88)
Query Neighborhood Hits	197	Target Neighborhood Hits	323	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

GOPC_HUMAN
NC score	0.153328 (rank : 61)	θ value	0.279714 (rank : 87)
Query Neighborhood Hits	197	Target Neighborhood Hits	377	Shared Neighborhood Hits	65
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

PDZD2_HUMAN
NC score	0.150494 (rank : 62)	θ value	0.125558 (rank : 72)
Query Neighborhood Hits	197	Target Neighborhood Hits	772	Shared Neighborhood Hits	67
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

GIPC2_HUMAN
NC score	0.150452 (rank : 63)	θ value	0.163984 (rank : 76)
Query Neighborhood Hits	197	Target Neighborhood Hits	93	Shared Neighborhood Hits	45
SwissProt Accessions	Q8TF65, Q8IYD3, Q9NXS7	Gene names	GIPC2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2.

SAM10_MOUSE
NC score	0.149419 (rank : 64)	θ value	0.125558 (rank : 73)
Query Neighborhood Hits	197	Target Neighborhood Hits	23	Shared Neighborhood Hits	14
SwissProt Accessions	Q7TST3	Gene names	Samd10
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 10.

DYN3_HUMAN
NC score	0.146103 (rank : 65)	θ value	0.0961366 (rank : 70)
Query Neighborhood Hits	197	Target Neighborhood Hits	158	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

TARA_MOUSE
NC score	0.146041 (rank : 66)	θ value	0.0563607 (rank : 62)
Query Neighborhood Hits	197	Target Neighborhood Hits	1133	Shared Neighborhood Hits	76
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

PKHB2_HUMAN
NC score	0.144346 (rank : 67)	θ value	1.81305 (rank : 130)
Query Neighborhood Hits	197	Target Neighborhood Hits	54	Shared Neighborhood Hits	32
SwissProt Accessions	Q96CS7, Q86W37, Q9BV75, Q9NWK1	Gene names	PLEKHB2, EVT2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

LIN7B_HUMAN
NC score	0.142908 (rank : 68)	θ value	0.365318 (rank : 90)
Query Neighborhood Hits	197	Target Neighborhood Hits	200	Shared Neighborhood Hits	52
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

FGD6_MOUSE
NC score	0.140224 (rank : 69)	θ value	0.00665767 (rank : 47)
Query Neighborhood Hits	197	Target Neighborhood Hits	282	Shared Neighborhood Hits	41
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD6_HUMAN
NC score	0.138812 (rank : 70)	θ value	0.00298849 (rank : 38)
Query Neighborhood Hits	197	Target Neighborhood Hits	237	Shared Neighborhood Hits	37
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

SNTG2_HUMAN
NC score	0.137344 (rank : 71)	θ value	0.125558 (rank : 74)
Query Neighborhood Hits	197	Target Neighborhood Hits	191	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

LIN7B_MOUSE
NC score	0.137133 (rank : 72)	θ value	1.38821 (rank : 121)
Query Neighborhood Hits	197	Target Neighborhood Hits	200	Shared Neighborhood Hits	52
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

GIPC2_MOUSE
NC score	0.136631 (rank : 73)	θ value	0.279714 (rank : 86)
Query Neighborhood Hits	197	Target Neighborhood Hits	71	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Z2H7, Q9CVG2	Gene names	Gipc2, Semcap2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2 (SemaF cytoplasmic domain- associated protein 2) (SEMCAP-2).

LIN7C_HUMAN
NC score	0.135986 (rank : 74)	θ value	1.81305 (rank : 127)
Query Neighborhood Hits	197	Target Neighborhood Hits	198	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
NC score	0.135986 (rank : 75)	θ value	1.81305 (rank : 128)
Query Neighborhood Hits	197	Target Neighborhood Hits	198	Shared Neighborhood Hits	52
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

APBA3_MOUSE
NC score	0.135541 (rank : 76)	θ value	0.0563607 (rank : 60)
Query Neighborhood Hits	197	Target Neighborhood Hits	174	Shared Neighborhood Hits	50
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

PKHB1_HUMAN
NC score	0.134272 (rank : 77)	θ value	2.36792 (rank : 139)
Query Neighborhood Hits	197	Target Neighborhood Hits	46	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

DYN1_MOUSE
NC score	0.133383 (rank : 78)	θ value	0.0736092 (rank : 65)
Query Neighborhood Hits	197	Target Neighborhood Hits	168	Shared Neighborhood Hits	30
SwissProt Accessions	P39053, Q61358, Q61359, Q61360, Q8JZZ4, Q9CSY7, Q9QXX1	Gene names	Dnm1, Dnm
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

GIPC3_HUMAN
NC score	0.133326 (rank : 79)	θ value	0.62314 (rank : 94)
Query Neighborhood Hits	197	Target Neighborhood Hits	52	Shared Neighborhood Hits	31
SwissProt Accessions	Q8TF64, O75227	Gene names	GIPC3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3.

DYN1_HUMAN
NC score	0.132647 (rank : 80)	θ value	0.0736092 (rank : 64)
Query Neighborhood Hits	197	Target Neighborhood Hits	216	Shared Neighborhood Hits	31
SwissProt Accessions	Q05193	Gene names	DNM1, DNM
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

GIPC3_MOUSE
NC score	0.132380 (rank : 81)	θ value	0.62314 (rank : 95)
Query Neighborhood Hits	197	Target Neighborhood Hits	53	Shared Neighborhood Hits	32
SwissProt Accessions	Q8R5M0	Gene names	Gipc3, Rgs19ip3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3 (Regulator of G-protein signaling 19-interacting protein 3).

PKHB2_MOUSE
NC score	0.128945 (rank : 82)	θ value	6.88961 (rank : 181)
Query Neighborhood Hits	197	Target Neighborhood Hits	48	Shared Neighborhood Hits	31
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

SHAN1_HUMAN
NC score	0.127182 (rank : 83)	θ value	0.00509761 (rank : 46)
Query Neighborhood Hits	197	Target Neighborhood Hits	1041	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

PKHB1_MOUSE
NC score	0.127031 (rank : 84)	θ value	1.81305 (rank : 129)
Query Neighborhood Hits	197	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

LIN7A_MOUSE
NC score	0.126645 (rank : 85)	θ value	5.27518 (rank : 161)
Query Neighborhood Hits	197	Target Neighborhood Hits	193	Shared Neighborhood Hits	51
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

LIN7A_HUMAN
NC score	0.126422 (rank : 86)	θ value	5.27518 (rank : 160)
Query Neighborhood Hits	197	Target Neighborhood Hits	193	Shared Neighborhood Hits	51
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

SNTG2_MOUSE
NC score	0.125033 (rank : 87)	θ value	0.813845 (rank : 112)
Query Neighborhood Hits	197	Target Neighborhood Hits	176	Shared Neighborhood Hits	48
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SNTG1_HUMAN
NC score	0.124357 (rank : 88)	θ value	2.36792 (rank : 142)
Query Neighborhood Hits	197	Target Neighborhood Hits	181	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

PSD4_HUMAN
NC score	0.123661 (rank : 89)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	197	Target Neighborhood Hits	178	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

SNTG1_MOUSE
NC score	0.117863 (rank : 90)	θ value	6.88961 (rank : 182)
Query Neighborhood Hits	197	Target Neighborhood Hits	179	Shared Neighborhood Hits	49
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

APBA3_HUMAN
NC score	0.116133 (rank : 91)	θ value	1.81305 (rank : 124)
Query Neighborhood Hits	197	Target Neighborhood Hits	201	Shared Neighborhood Hits	51
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

FARP1_HUMAN
NC score	0.116016 (rank : 92)	θ value	0.0113563 (rank : 49)
Query Neighborhood Hits	197	Target Neighborhood Hits	241	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

TARA_HUMAN
NC score	0.113210 (rank : 93)	θ value	0.125558 (rank : 75)
Query Neighborhood Hits	197	Target Neighborhood Hits	1626	Shared Neighborhood Hits	86
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

DAPP1_MOUSE
NC score	0.113037 (rank : 94)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	197	Target Neighborhood Hits	225	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PSD4_MOUSE
NC score	0.112929 (rank : 95)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	197	Target Neighborhood Hits	78	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

IL16_MOUSE
NC score	0.112420 (rank : 96)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	197	Target Neighborhood Hits	189	Shared Neighborhood Hits	40
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

PKHA3_MOUSE
NC score	0.111516 (rank : 97)	θ value	0.813845 (rank : 109)
Query Neighborhood Hits	197	Target Neighborhood Hits	67	Shared Neighborhood Hits	32
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

DAPP1_HUMAN
NC score	0.108158 (rank : 98)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	197	Target Neighborhood Hits	227	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PKHA3_HUMAN
NC score	0.108039 (rank : 99)	θ value	0.813845 (rank : 108)
Query Neighborhood Hits	197	Target Neighborhood Hits	66	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

FARP2_MOUSE
NC score	0.107958 (rank : 100)	θ value	0.279714 (rank : 85)
Query Neighborhood Hits	197	Target Neighborhood Hits	209	Shared Neighborhood Hits	43
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

PLEK2_HUMAN
NC score	0.106570 (rank : 101)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	197	Target Neighborhood Hits	101	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PDZD7_HUMAN
NC score	0.106353 (rank : 102)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	197	Target Neighborhood Hits	181	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

PARD3_HUMAN
NC score	0.105739 (rank : 103)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	197	Target Neighborhood Hits	312	Shared Neighborhood Hits	54
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

3BP2_HUMAN
NC score	0.105218 (rank : 104)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	197	Target Neighborhood Hits	296	Shared Neighborhood Hits	35
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

3BP2_MOUSE
NC score	0.105088 (rank : 105)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	197	Target Neighborhood Hits	142	Shared Neighborhood Hits	27
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

SYJ2B_HUMAN
NC score	0.104996 (rank : 106)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	197	Target Neighborhood Hits	162	Shared Neighborhood Hits	39
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

PARD3_MOUSE
NC score	0.104515 (rank : 107)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	197	Target Neighborhood Hits	290	Shared Neighborhood Hits	54
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

LNX1_HUMAN
NC score	0.104377 (rank : 108)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	197	Target Neighborhood Hits	379	Shared Neighborhood Hits	53
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

MYO10_HUMAN
NC score	0.103987 (rank : 109)	θ value	1.43324e-05 (rank : 14)
Query Neighborhood Hits	197	Target Neighborhood Hits	920	Shared Neighborhood Hits	76
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

PLEK2_MOUSE
NC score	0.103729 (rank : 110)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	197	Target Neighborhood Hits	96	Shared Neighborhood Hits	42
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PZRN4_HUMAN
NC score	0.103474 (rank : 111)	θ value	0.62314 (rank : 96)
Query Neighborhood Hits	197	Target Neighborhood Hits	438	Shared Neighborhood Hits	52
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

LNX1_MOUSE
NC score	0.103471 (rank : 112)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	197	Target Neighborhood Hits	377	Shared Neighborhood Hits	56
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

BFAR_HUMAN
NC score	0.101329 (rank : 113)	θ value	0.0330416 (rank : 54)
Query Neighborhood Hits	197	Target Neighborhood Hits	222	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NZS9	Gene names	BFAR, BAR, RNF47
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator (RING finger protein 47).

FARP2_HUMAN
NC score	0.101204 (rank : 114)	θ value	0.62314 (rank : 93)
Query Neighborhood Hits	197	Target Neighborhood Hits	240	Shared Neighborhood Hits	39
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

LNX2_HUMAN
NC score	0.099952 (rank : 115)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	197	Target Neighborhood Hits	389	Shared Neighborhood Hits	52
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

PAR3L_HUMAN
NC score	0.099000 (rank : 116)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	197	Target Neighborhood Hits	297	Shared Neighborhood Hits	48
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

GBF1_HUMAN
NC score	0.098038 (rank : 117)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	197	Target Neighborhood Hits	142	Shared Neighborhood Hits	12
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

USH1C_HUMAN
NC score	0.097914 (rank : 118)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	197	Target Neighborhood Hits	327	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

LNX2_MOUSE
NC score	0.097686 (rank : 119)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	197	Target Neighborhood Hits	407	Shared Neighborhood Hits	55
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

APBA1_HUMAN
NC score	0.096852 (rank : 120)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	197	Target Neighborhood Hits	325	Shared Neighborhood Hits	53
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

BIG2_HUMAN
NC score	0.096743 (rank : 121)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	197	Target Neighborhood Hits	66	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

BIG1_HUMAN
NC score	0.096247 (rank : 122)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	197	Target Neighborhood Hits	76	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

BFAR_MOUSE
NC score	0.095697 (rank : 123)	θ value	0.0431538 (rank : 57)
Query Neighborhood Hits	197	Target Neighborhood Hits	232	Shared Neighborhood Hits	15
SwissProt Accessions	Q8R079, Q8C1A7, Q9CXY3	Gene names	Bfar
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator.

WHRN_HUMAN
NC score	0.094865 (rank : 124)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	197	Target Neighborhood Hits	325	Shared Neighborhood Hits	57
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

SNTA1_HUMAN
NC score	0.093742 (rank : 125)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	197	Target Neighborhood Hits	186	Shared Neighborhood Hits	52
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

WHRN_MOUSE
NC score	0.093724 (rank : 126)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	197	Target Neighborhood Hits	412	Shared Neighborhood Hits	57
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

IQEC3_MOUSE
NC score	0.092884 (rank : 127)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	197	Target Neighborhood Hits	274	Shared Neighborhood Hits	22
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

PDZD1_MOUSE
NC score	0.092216 (rank : 128)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	197	Target Neighborhood Hits	191	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

NHERF_MOUSE
NC score	0.091365 (rank : 129)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	197	Target Neighborhood Hits	195	Shared Neighborhood Hits	43
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHRF2_HUMAN
NC score	0.091295 (rank : 130)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	197	Target Neighborhood Hits	197	Shared Neighborhood Hits	49
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

IQEC3_HUMAN
NC score	0.090928 (rank : 131)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	197	Target Neighborhood Hits	125	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

DLG1_HUMAN
NC score	0.090780 (rank : 132)	θ value	4.03905 (rank : 153)
Query Neighborhood Hits	197	Target Neighborhood Hits	290	Shared Neighborhood Hits	53
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

PDZ11_HUMAN
NC score	0.090632 (rank : 133)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	197	Target Neighborhood Hits	160	Shared Neighborhood Hits	39
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

SWP70_HUMAN
NC score	0.090262 (rank : 134)	θ value	4.03905 (rank : 156)
Query Neighborhood Hits	197	Target Neighborhood Hits	973	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

PTN13_HUMAN
NC score	0.090145 (rank : 135)	θ value	0.21417 (rank : 83)
Query Neighborhood Hits	197	Target Neighborhood Hits	471	Shared Neighborhood Hits	61
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

USH1C_MOUSE
NC score	0.089852 (rank : 136)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	197	Target Neighborhood Hits	557	Shared Neighborhood Hits	62
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

PDZD1_HUMAN
NC score	0.089517 (rank : 137)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	197	Target Neighborhood Hits	190	Shared Neighborhood Hits	45
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

FBX8_MOUSE
NC score	0.089503 (rank : 138)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	197	Target Neighborhood Hits	45	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QZN3	Gene names	Fbxo8, Fbx8
Domain Architecture
Description	F-box only protein 8.

NEB2_HUMAN
NC score	0.089321 (rank : 139)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	197	Target Neighborhood Hits	883	Shared Neighborhood Hits	71
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

SNTA1_MOUSE
NC score	0.089293 (rank : 140)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	197	Target Neighborhood Hits	170	Shared Neighborhood Hits	47
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

FBX8_HUMAN
NC score	0.089149 (rank : 141)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	197	Target Neighborhood Hits	44	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NRD0, Q6UWN4, Q9NRP5, Q9UKC4	Gene names	FBXO8, FBS, FBX8
Domain Architecture
Description	F-box only protein 8 (F-box/SEC7 protein FBS).

K1849_HUMAN
NC score	0.088475 (rank : 142)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	197	Target Neighborhood Hits	220	Shared Neighborhood Hits	45
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

NEB2_MOUSE
NC score	0.088363 (rank : 143)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	197	Target Neighborhood Hits	889	Shared Neighborhood Hits	72
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NHRF2_MOUSE
NC score	0.088260 (rank : 144)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	197	Target Neighborhood Hits	194	Shared Neighborhood Hits	49
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

PDZ11_MOUSE
NC score	0.088186 (rank : 145)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	197	Target Neighborhood Hits	154	Shared Neighborhood Hits	36
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

SWP70_MOUSE
NC score	0.088081 (rank : 146)	θ value	4.03905 (rank : 157)
Query Neighborhood Hits	197	Target Neighborhood Hits	1097	Shared Neighborhood Hits	71
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SNTB2_HUMAN
NC score	0.087849 (rank : 147)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	197	Target Neighborhood Hits	180	Shared Neighborhood Hits	48
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

SNTB2_MOUSE
NC score	0.087484 (rank : 148)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	197	Target Neighborhood Hits	181	Shared Neighborhood Hits	48
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

DLG3_MOUSE
NC score	0.087307 (rank : 149)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	197	Target Neighborhood Hits	274	Shared Neighborhood Hits	53
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

DLG2_HUMAN
NC score	0.086429 (rank : 150)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	197	Target Neighborhood Hits	279	Shared Neighborhood Hits	51
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

K1849_MOUSE
NC score	0.086179 (rank : 151)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	197	Target Neighborhood Hits	335	Shared Neighborhood Hits	53
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

DLG3_HUMAN
NC score	0.086035 (rank : 152)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	197	Target Neighborhood Hits	269	Shared Neighborhood Hits	53
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

AFAD_HUMAN
NC score	0.085808 (rank : 153)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	197	Target Neighborhood Hits	689	Shared Neighborhood Hits	67
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

DLG2_MOUSE
NC score	0.085769 (rank : 154)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	197	Target Neighborhood Hits	271	Shared Neighborhood Hits	50
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

IQEC1_HUMAN
NC score	0.085481 (rank : 155)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	197	Target Neighborhood Hits	76	Shared Neighborhood Hits	14
SwissProt Accessions	Q6DN90, O94863, Q96D85	Gene names	IQSEC1, ARFGEP100, BRAG2, KIAA0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein).

DLG4_MOUSE
NC score	0.084928 (rank : 156)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	197	Target Neighborhood Hits	282	Shared Neighborhood Hits	51
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_HUMAN
NC score	0.084709 (rank : 157)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	197	Target Neighborhood Hits	286	Shared Neighborhood Hits	50
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

PTN13_MOUSE
NC score	0.084425 (rank : 158)	θ value	1.38821 (rank : 122)
Query Neighborhood Hits	197	Target Neighborhood Hits	426	Shared Neighborhood Hits	60
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

PHLB1_MOUSE
NC score	0.084404 (rank : 159)	θ value	5.27518 (rank : 163)
Query Neighborhood Hits	197	Target Neighborhood Hits	678	Shared Neighborhood Hits	57
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

LIPB1_MOUSE
NC score	0.084348 (rank : 160)	θ value	0.0330416 (rank : 56)
Query Neighborhood Hits	197	Target Neighborhood Hits	727	Shared Neighborhood Hits	45
SwissProt Accessions	Q8C8U0, Q69ZN5, Q6GQV3, Q80VB4, Q9CUT7	Gene names	Ppfibp1, Kiaa1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1).

SNTB1_MOUSE
NC score	0.084187 (rank : 161)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	197	Target Neighborhood Hits	160	Shared Neighborhood Hits	46
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

SNTB1_HUMAN
NC score	0.084152 (rank : 162)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	197	Target Neighborhood Hits	157	Shared Neighborhood Hits	45
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

IQEC1_MOUSE
NC score	0.083784 (rank : 163)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	197	Target Neighborhood Hits	54	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R0S2, Q3TZC3, Q5DU15	Gene names	Iqsec1, Kiaa0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1.

DLG1_MOUSE
NC score	0.083749 (rank : 164)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	197	Target Neighborhood Hits	285	Shared Neighborhood Hits	48
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

ANLN_HUMAN
NC score	0.083656 (rank : 165)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	197	Target Neighborhood Hits	222	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NQW6, Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0	Gene names	ANLN
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

PHLB1_HUMAN
NC score	0.083566 (rank : 166)	θ value	3.0926 (rank : 148)
Query Neighborhood Hits	197	Target Neighborhood Hits	1038	Shared Neighborhood Hits	65
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

GNRP_HUMAN
NC score	0.083434 (rank : 167)	θ value	2.36792 (rank : 135)
Query Neighborhood Hits	197	Target Neighborhood Hits	239	Shared Neighborhood Hits	39
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

APBA2_MOUSE
NC score	0.083215 (rank : 168)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	197	Target Neighborhood Hits	219	Shared Neighborhood Hits	45
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

NHERF_HUMAN
NC score	0.083186 (rank : 169)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	197	Target Neighborhood Hits	190	Shared Neighborhood Hits	42
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

APBA2_HUMAN
NC score	0.082978 (rank : 170)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	197	Target Neighborhood Hits	220	Shared Neighborhood Hits	46
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

SDCB1_MOUSE
NC score	0.082562 (rank : 171)	θ value	2.36792 (rank : 141)
Query Neighborhood Hits	197	Target Neighborhood Hits	144	Shared Neighborhood Hits	47
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

SAMH1_MOUSE
NC score	0.082019 (rank : 172)	θ value	1.06291 (rank : 114)
Query Neighborhood Hits	197	Target Neighborhood Hits	19	Shared Neighborhood Hits	9
SwissProt Accessions	Q60710, Q91VK8	Gene names	Samhd1, Mg11
Domain Architecture
Description	SAM domain and HD domain-containing protein 1 (Interferon-gamma- inducible protein Mg11).

TIAM1_HUMAN
NC score	0.081375 (rank : 173)	θ value	0.62314 (rank : 97)
Query Neighborhood Hits	197	Target Neighborhood Hits	225	Shared Neighborhood Hits	49
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

PDZD3_HUMAN
NC score	0.079758 (rank : 174)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	197	Target Neighborhood Hits	180	Shared Neighborhood Hits	45
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

IQEC2_MOUSE
NC score	0.079715 (rank : 175)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	197	Target Neighborhood Hits	417	Shared Neighborhood Hits	25
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

SDCB1_HUMAN
NC score	0.079381 (rank : 176)	θ value	2.36792 (rank : 140)
Query Neighborhood Hits	197	Target Neighborhood Hits	150	Shared Neighborhood Hits	48
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

MPP3_MOUSE
NC score	0.078982 (rank : 177)	θ value	2.36792 (rank : 137)
Query Neighborhood Hits	197	Target Neighborhood Hits	165	Shared Neighborhood Hits	48
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

IQEC2_HUMAN
NC score	0.078710 (rank : 178)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	197	Target Neighborhood Hits	403	Shared Neighborhood Hits	24
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

TX1B3_HUMAN
NC score	0.078682 (rank : 179)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	197	Target Neighborhood Hits	161	Shared Neighborhood Hits	42
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

PICK1_MOUSE
NC score	0.078571 (rank : 180)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	197	Target Neighborhood Hits	131	Shared Neighborhood Hits	44
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

ZO3_HUMAN
NC score	0.078445 (rank : 181)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	197	Target Neighborhood Hits	219	Shared Neighborhood Hits	46
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

DYDC2_HUMAN
NC score	0.078234 (rank : 182)	θ value	0.813845 (rank : 102)
Query Neighborhood Hits	197	Target Neighborhood Hits	55	Shared Neighborhood Hits	4
SwissProt Accessions	Q96IM9, Q5QP07, Q5QP11	Gene names	DYDC2
Domain Architecture	No domain graphic available
Description	DPY30 domain-containing protein 2.

TX1B3_MOUSE
NC score	0.078172 (rank : 183)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	197	Target Neighborhood Hits	158	Shared Neighborhood Hits	42
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

PDZD3_MOUSE
NC score	0.078155 (rank : 184)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	197	Target Neighborhood Hits	171	Shared Neighborhood Hits	46
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

STXB4_HUMAN
NC score	0.077970 (rank : 185)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	197	Target Neighborhood Hits	616	Shared Neighborhood Hits	54
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

RAPH1_HUMAN
NC score	0.077869 (rank : 186)	θ value	0.0736092 (rank : 69)
Query Neighborhood Hits	197	Target Neighborhood Hits	593	Shared Neighborhood Hits	32
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

ZO3_MOUSE
NC score	0.077741 (rank : 187)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	197	Target Neighborhood Hits	224	Shared Neighborhood Hits	48
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

PICK1_HUMAN
NC score	0.077619 (rank : 188)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	197	Target Neighborhood Hits	132	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

ZO2_HUMAN
NC score	0.077157 (rank : 189)	θ value	5.27518 (rank : 172)
Query Neighborhood Hits	197	Target Neighborhood Hits	289	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

CEND1_HUMAN
NC score	0.075861 (rank : 190)	θ value	5.27518 (rank : 159)
Query Neighborhood Hits	197	Target Neighborhood Hits	284	Shared Neighborhood Hits	62
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

LIPB1_HUMAN
NC score	0.075679 (rank : 191)	θ value	0.163984 (rank : 78)
Query Neighborhood Hits	197	Target Neighborhood Hits	640	Shared Neighborhood Hits	42
SwissProt Accessions	Q86W92, O75336, Q86X70, Q9NY03, Q9ULJ0	Gene names	PPFIBP1, KIAA1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2).

PSCBP_MOUSE
NC score	0.075387 (rank : 192)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	197	Target Neighborhood Hits	118	Shared Neighborhood Hits	33
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

CENB2_HUMAN
NC score	0.075372 (rank : 193)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	197	Target Neighborhood Hits	425	Shared Neighborhood Hits	53
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

PZRN3_MOUSE
NC score	0.075369 (rank : 194)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	197	Target Neighborhood Hits	447	Shared Neighborhood Hits	49
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PSCBP_HUMAN
NC score	0.074538 (rank : 195)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	197	Target Neighborhood Hits	123	Shared Neighborhood Hits	33
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

PZRN3_HUMAN
NC score	0.074491 (rank : 196)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	197	Target Neighborhood Hits	461	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

GRASP_HUMAN
NC score	0.074340 (rank : 197)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	197	Target Neighborhood Hits	147	Shared Neighborhood Hits	34
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

LIPB2_MOUSE
NC score	0.074318 (rank : 198)	θ value	0.365318 (rank : 91)
Query Neighborhood Hits	197	Target Neighborhood Hits	570	Shared Neighborhood Hits	38
SwissProt Accessions	O35711, Q7TMG4, Q8CBS6, Q99KX6	Gene names	Ppfibp2, Cclp1
Domain Architecture
Description	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) (Coiled-coil-like protein 1).

AB1IP_MOUSE
NC score	0.074152 (rank : 199)	θ value	0.813845 (rank : 100)
Query Neighborhood Hits	197	Target Neighborhood Hits	181	Shared Neighborhood Hits	27
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

STXB4_MOUSE
NC score	0.074076 (rank : 200)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	197	Target Neighborhood Hits	629	Shared Neighborhood Hits	55
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

FGD1_HUMAN
NC score	0.073614 (rank : 201)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	197	Target Neighborhood Hits	367	Shared Neighborhood Hits	34
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

GNRP_MOUSE
NC score	0.073095 (rank : 202)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	197	Target Neighborhood Hits	191	Shared Neighborhood Hits	36
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

FGD1_MOUSE
NC score	0.073086 (rank : 203)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	197	Target Neighborhood Hits	387	Shared Neighborhood Hits	35
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

MPP3_HUMAN
NC score	0.073077 (rank : 204)	θ value	5.27518 (rank : 162)
Query Neighborhood Hits	197	Target Neighborhood Hits	171	Shared Neighborhood Hits	48
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

ZO1_MOUSE
NC score	0.072789 (rank : 205)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	197	Target Neighborhood Hits	453	Shared Neighborhood Hits	53
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

MTMR5_HUMAN
NC score	0.072659 (rank : 206)	θ value	0.813845 (rank : 105)
Query Neighborhood Hits	197	Target Neighborhood Hits	141	Shared Neighborhood Hits	32
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

CENB5_HUMAN
NC score	0.072362 (rank : 207)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	197	Target Neighborhood Hits	395	Shared Neighborhood Hits	51
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

TIAM1_MOUSE
NC score	0.072077 (rank : 208)	θ value	0.62314 (rank : 98)
Query Neighborhood Hits	197	Target Neighborhood Hits	205	Shared Neighborhood Hits	39
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ZO2_MOUSE
NC score	0.072021 (rank : 209)	θ value	8.99809 (rank : 197)
Query Neighborhood Hits	197	Target Neighborhood Hits	296	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZO1_HUMAN
NC score	0.071975 (rank : 210)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	197	Target Neighborhood Hits	474	Shared Neighborhood Hits	53
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

GRASP_MOUSE
NC score	0.071905 (rank : 211)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	197	Target Neighborhood Hits	131	Shared Neighborhood Hits	33
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

EM55_MOUSE
NC score	0.071792 (rank : 212)	θ value	1.38821 (rank : 119)
Query Neighborhood Hits	197	Target Neighborhood Hits	221	Shared Neighborhood Hits	50
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

AB1IP_HUMAN
NC score	0.070644 (rank : 213)	θ value	2.36792 (rank : 133)
Query Neighborhood Hits	197	Target Neighborhood Hits	213	Shared Neighborhood Hits	27
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

EM55_HUMAN
NC score	0.070006 (rank : 214)	θ value	3.0926 (rank : 145)
Query Neighborhood Hits	197	Target Neighborhood Hits	228	Shared Neighborhood Hits	50
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

CSKI2_HUMAN
NC score	0.069791 (rank : 215)	θ value	0.0330416 (rank : 55)
Query Neighborhood Hits	197	Target Neighborhood Hits	747	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

ANLN_MOUSE
NC score	0.069452 (rank : 216)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	197	Target Neighborhood Hits	297	Shared Neighborhood Hits	28
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

OSBP1_HUMAN
NC score	0.069166 (rank : 217)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	197	Target Neighborhood Hits	180	Shared Neighborhood Hits	49
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

MPP4_HUMAN
NC score	0.068613 (rank : 218)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	197	Target Neighborhood Hits	205	Shared Neighborhood Hits	45
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

ARHGB_HUMAN
NC score	0.067264 (rank : 219)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	197	Target Neighborhood Hits	375	Shared Neighborhood Hits	57
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

CSKI2_MOUSE
NC score	0.066374 (rank : 220)	θ value	0.0736092 (rank : 63)
Query Neighborhood Hits	197	Target Neighborhood Hits	812	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

OSBP2_HUMAN
NC score	0.066058 (rank : 221)	θ value	2.36792 (rank : 138)
Query Neighborhood Hits	197	Target Neighborhood Hits	154	Shared Neighborhood Hits	43
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

LAP4_HUMAN
NC score	0.065025 (rank : 222)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	197	Target Neighborhood Hits	608	Shared Neighborhood Hits	58
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

ARHGC_HUMAN
NC score	0.064840 (rank : 223)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	197	Target Neighborhood Hits	351	Shared Neighborhood Hits	64
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

LAP4_MOUSE
NC score	0.064597 (rank : 224)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	197	Target Neighborhood Hits	590	Shared Neighborhood Hits	56
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

MPP5_HUMAN
NC score	0.064412 (rank : 225)	θ value	8.99809 (rank : 188)
Query Neighborhood Hits	197	Target Neighborhood Hits	231	Shared Neighborhood Hits	49
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
NC score	0.063865 (rank : 226)	θ value	8.99809 (rank : 189)
Query Neighborhood Hits	197	Target Neighborhood Hits	226	Shared Neighborhood Hits	49
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

TNKS2_HUMAN
NC score	0.063639 (rank : 227)	θ value	0.00035302 (rank : 21)
Query Neighborhood Hits	197	Target Neighborhood Hits	361	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

MPP4_MOUSE
NC score	0.063316 (rank : 228)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	197	Target Neighborhood Hits	188	Shared Neighborhood Hits	46
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

SAMH1_HUMAN
NC score	0.063109 (rank : 229)	θ value	1.06291 (rank : 113)
Query Neighborhood Hits	197	Target Neighborhood Hits	14	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y3Z3, Q5JXG8, Q9H004, Q9H005, Q9H3U9	Gene names	SAMHD1, MOP5
Domain Architecture
Description	SAM domain and HD domain-containing protein 1 (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5).

ARHGC_MOUSE
NC score	0.062895 (rank : 230)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	197	Target Neighborhood Hits	344	Shared Neighborhood Hits	62
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

FGD4_HUMAN
NC score	0.062774 (rank : 231)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	197	Target Neighborhood Hits	219	Shared Neighborhood Hits	30
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

PDLI2_HUMAN
NC score	0.062289 (rank : 232)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	197	Target Neighborhood Hits	245	Shared Neighborhood Hits	34
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

DLG5_HUMAN
NC score	0.061666 (rank : 233)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	197	Target Neighborhood Hits	1088	Shared Neighborhood Hits	81
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

DNM1L_MOUSE
NC score	0.061385 (rank : 234)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	197	Target Neighborhood Hits	28	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K1M6, Q8BNQ5, Q8BQ64, Q8CGD0, Q8K1A1	Gene names	Dnm1l, Drp1
Domain Architecture	No domain graphic available
Description	Dynamin-1-like protein (EC 3.6.5.5) (Dynamin-related protein 1) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple).

DNM1L_HUMAN
NC score	0.061354 (rank : 235)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	197	Target Neighborhood Hits	39	Shared Neighborhood Hits	5
SwissProt Accessions	O00429, O14541, O60709, Q7L6B3, Q8TBT7, Q9BWM1, Q9Y5J2	Gene names	DNM1L, DLP1, DRP1
Domain Architecture	No domain graphic available
Description	Dynamin-1-like protein (EC 3.6.5.5) (Dynamin-like protein) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-related protein 1) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV).

SAV1_HUMAN
NC score	0.060748 (rank : 236)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	197	Target Neighborhood Hits	51	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

CEND3_HUMAN
NC score	0.060726 (rank : 237)	θ value	2.36792 (rank : 134)
Query Neighborhood Hits	197	Target Neighborhood Hits	275	Shared Neighborhood Hits	42
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

PHLB2_MOUSE
NC score	0.060642 (rank : 238)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	197	Target Neighborhood Hits	1016	Shared Neighborhood Hits	56
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

SAV1_MOUSE
NC score	0.060549 (rank : 239)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	197	Target Neighborhood Hits	48	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

FGD4_MOUSE
NC score	0.060032 (rank : 240)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	197	Target Neighborhood Hits	227	Shared Neighborhood Hits	30
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

C43BP_MOUSE
NC score	0.059789 (rank : 241)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	197	Target Neighborhood Hits	91	Shared Neighborhood Hits	38
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

CENB1_HUMAN
NC score	0.059734 (rank : 242)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	197	Target Neighborhood Hits	383	Shared Neighborhood Hits	48
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

FGD2_MOUSE
NC score	0.059711 (rank : 243)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	197	Target Neighborhood Hits	163	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

LIPB2_HUMAN
NC score	0.058616 (rank : 244)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	197	Target Neighborhood Hits	599	Shared Neighborhood Hits	41
SwissProt Accessions	Q8ND30, O75337, Q8WW26	Gene names	PPFIBP2
Domain Architecture
Description	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2).

SDCB2_MOUSE
NC score	0.058580 (rank : 245)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	197	Target Neighborhood Hits	118	Shared Neighborhood Hits	41
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

PDLI2_MOUSE
NC score	0.058358 (rank : 246)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	197	Target Neighborhood Hits	220	Shared Neighborhood Hits	36
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

PHLB2_HUMAN
NC score	0.058289 (rank : 247)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	197	Target Neighborhood Hits	964	Shared Neighborhood Hits	56
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

SYP2L_HUMAN
NC score	0.058263 (rank : 248)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	197	Target Neighborhood Hits	400	Shared Neighborhood Hits	39
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

RHPN1_MOUSE
NC score	0.058041 (rank : 249)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	197	Target Neighborhood Hits	154	Shared Neighborhood Hits	39
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

C43BP_HUMAN
NC score	0.057597 (rank : 250)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	197	Target Neighborhood Hits	87	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

CEND2_HUMAN
NC score	0.057205 (rank : 251)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	197	Target Neighborhood Hits	166	Shared Neighborhood Hits	39
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

MTMRD_HUMAN
NC score	0.056514 (rank : 252)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	197	Target Neighborhood Hits	135	Shared Neighborhood Hits	39
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

FGD3_MOUSE
NC score	0.056482 (rank : 253)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	197	Target Neighborhood Hits	257	Shared Neighborhood Hits	26
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

RASA1_HUMAN
NC score	0.056410 (rank : 254)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	197	Target Neighborhood Hits	258	Shared Neighborhood Hits	32
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

TNKS1_HUMAN
NC score	0.055347 (rank : 255)	θ value	0.0252991 (rank : 53)
Query Neighborhood Hits	197	Target Neighborhood Hits	477	Shared Neighborhood Hits	23
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

FGD2_HUMAN
NC score	0.054900 (rank : 256)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	197	Target Neighborhood Hits	151	Shared Neighborhood Hits	21
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

APXL_HUMAN
NC score	0.054702 (rank : 257)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	197	Target Neighborhood Hits	553	Shared Neighborhood Hits	42
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

ANKS6_MOUSE
NC score	0.054664 (rank : 258)	θ value	0.279714 (rank : 84)
Query Neighborhood Hits	197	Target Neighborhood Hits	435	Shared Neighborhood Hits	25
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

ANKS6_HUMAN
NC score	0.054647 (rank : 259)	θ value	0.365318 (rank : 89)
Query Neighborhood Hits	197	Target Neighborhood Hits	411	Shared Neighborhood Hits	24
SwissProt Accessions	Q68DC2, Q5VSL0, Q5VSL2, Q5VSL3, Q5VSL4, Q68DB8, Q6P2R2, Q8N9L6, Q96D62	Gene names	ANKS6, ANKRD14, SAMD6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6) (Ankyrin repeat domain-containing protein 14).

PDZK4_MOUSE
NC score	0.054221 (rank : 260)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	197	Target Neighborhood Hits	165	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PAR6G_MOUSE
NC score	0.053781 (rank : 261)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	197	Target Neighborhood Hits	121	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

DVL3_MOUSE
NC score	0.053669 (rank : 262)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	197	Target Neighborhood Hits	198	Shared Neighborhood Hits	43
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

PAR6A_HUMAN
NC score	0.053627 (rank : 263)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	197	Target Neighborhood Hits	119	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

SDCB2_HUMAN
NC score	0.053599 (rank : 264)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	197	Target Neighborhood Hits	121	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

PAR6A_MOUSE
NC score	0.053120 (rank : 265)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	197	Target Neighborhood Hits	115	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

CEND3_MOUSE
NC score	0.053050 (rank : 266)	θ value	6.88961 (rank : 174)
Query Neighborhood Hits	197	Target Neighborhood Hits	228	Shared Neighborhood Hits	41
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

PDZK4_HUMAN
NC score	0.052476 (rank : 267)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	197	Target Neighborhood Hits	165	Shared Neighborhood Hits	38
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

CEND1_MOUSE
NC score	0.052436 (rank : 268)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	197	Target Neighborhood Hits	260	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

DVL3_HUMAN
NC score	0.052346 (rank : 269)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	197	Target Neighborhood Hits	194	Shared Neighborhood Hits	39
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

PAR6G_HUMAN
NC score	0.052100 (rank : 270)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	197	Target Neighborhood Hits	159	Shared Neighborhood Hits	41
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

DVL1_HUMAN
NC score	0.050807 (rank : 271)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	197	Target Neighborhood Hits	158	Shared Neighborhood Hits	43
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

WWC1_HUMAN
NC score	0.050638 (rank : 272)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	197	Target Neighborhood Hits	290	Shared Neighborhood Hits	15
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

AKAP2_MOUSE
NC score	0.050449 (rank : 273)	θ value	1.38821 (rank : 118)
Query Neighborhood Hits	197	Target Neighborhood Hits	385	Shared Neighborhood Hits	15
SwissProt Accessions	O54931, O54932, O54933	Gene names	Akap2
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2) (AKAP expressed in kidney and lung) (AKAP-KL).

SMS1_HUMAN
NC score	0.049374 (rank : 274)	θ value	0.813845 (rank : 111)
Query Neighborhood Hits	197	Target Neighborhood Hits	17	Shared Neighborhood Hits	7
SwissProt Accessions	Q86VZ5	Gene names	TMEM23, MOB
Domain Architecture
Description	Phosphatidylcholine:ceramide cholinephosphotransferase 1 (EC 2.7.-.-) (Transmembrane protein 23) (Sphingomyelin synthase 1) (Mob protein).

CA065_HUMAN
NC score	0.048192 (rank : 275)	θ value	0.813845 (rank : 101)
Query Neighborhood Hits	197	Target Neighborhood Hits	469	Shared Neighborhood Hits	20
SwissProt Accessions	Q8N715, Q8N746, Q8NA93	Gene names	C1orf65
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf65.

AKAP2_HUMAN
NC score	0.047860 (rank : 276)	θ value	1.38821 (rank : 117)
Query Neighborhood Hits	197	Target Neighborhood Hits	507	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y2D5, Q9UG26	Gene names	AKAP2, KIAA0920
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2).

STIM2_HUMAN
NC score	0.047152 (rank : 277)	θ value	1.38821 (rank : 123)
Query Neighborhood Hits	197	Target Neighborhood Hits	420	Shared Neighborhood Hits	23
SwissProt Accessions	Q9P246, Q96BF1, Q9BQH2, Q9H8R1	Gene names	STIM2, KIAA1482
Domain Architecture
Description	Stromal interaction molecule 2 precursor.

SMS1_MOUSE
NC score	0.047124 (rank : 278)	θ value	1.06291 (rank : 115)
Query Neighborhood Hits	197	Target Neighborhood Hits	18	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VCQ6, Q8C464, Q8C583, Q8C652	Gene names	Tmem23
Domain Architecture
Description	Phosphatidylcholine:ceramide cholinephosphotransferase 1 (EC 2.7.-.-) (Transmembrane protein 23) (Sphingomyelin synthase 1) (Mob protein).

RIMS1_HUMAN
NC score	0.046831 (rank : 279)	θ value	5.27518 (rank : 166)
Query Neighborhood Hits	197	Target Neighborhood Hits	437	Shared Neighborhood Hits	52
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

LMBL3_HUMAN
NC score	0.046474 (rank : 280)	θ value	0.813845 (rank : 103)
Query Neighborhood Hits	197	Target Neighborhood Hits	88	Shared Neighborhood Hits	14
SwissProt Accessions	Q96JM7, Q5VUM9, Q6P9B5	Gene names	L3MBTL3, KIAA1798
Domain Architecture	No domain graphic available
Description	Lethal(3)malignant brain tumor-like 3 protein (L(3)mbt-like 3 protein) (H-l(3)mbt-like protein).

CSKI1_MOUSE
NC score	0.046077 (rank : 281)	θ value	4.03905 (rank : 152)
Query Neighborhood Hits	197	Target Neighborhood Hits	1031	Shared Neighborhood Hits	34
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI1_HUMAN
NC score	0.045738 (rank : 282)	θ value	4.03905 (rank : 151)
Query Neighborhood Hits	197	Target Neighborhood Hits	997	Shared Neighborhood Hits	36
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

STIM2_MOUSE
NC score	0.045298 (rank : 283)	θ value	1.81305 (rank : 131)
Query Neighborhood Hits	197	Target Neighborhood Hits	403	Shared Neighborhood Hits	23
SwissProt Accessions	P83093, Q69ZI3, Q80VF4	Gene names	Stim2, Kiaa1482
Domain Architecture	No domain graphic available
Description	Stromal interaction molecule 2 precursor.

LMBL3_MOUSE
NC score	0.044836 (rank : 284)	θ value	0.813845 (rank : 104)
Query Neighborhood Hits	197	Target Neighborhood Hits	212	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BLB7, Q641L7, Q6ZPI2, Q8C0G4	Gene names	L3mbtl3
Domain Architecture	No domain graphic available
Description	Lethal(3)malignant brain tumor-like 3 protein (L(3)mbt-like 3 protein).

GOGA6_HUMAN
NC score	0.043868 (rank : 285)	θ value	0.163984 (rank : 77)
Query Neighborhood Hits	197	Target Neighborhood Hits	1007	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NYA3, Q9NYA7	Gene names	GOLGA6, GLP
Domain Architecture
Description	Golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein).

URP1_HUMAN
NC score	0.042031 (rank : 286)	θ value	0.62314 (rank : 99)
Query Neighborhood Hits	197	Target Neighborhood Hits	26	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BQL6, Q8IX34, Q8IYH2, Q9NWM2, Q9NXQ3	Gene names	URP1, C20orf42, KIND1
Domain Architecture
Description	Unc-112-related protein 1 (Kindlin-1) (Kindlerin) (Kindlin syndrome protein).

S23IP_MOUSE
NC score	0.039525 (rank : 287)	θ value	3.0926 (rank : 149)
Query Neighborhood Hits	197	Target Neighborhood Hits	363	Shared Neighborhood Hits	16
SwissProt Accessions	Q6NZC7, Q8BXY6	Gene names	Sec23ip
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein.

KIF1B_MOUSE
NC score	0.038699 (rank : 288)	θ value	0.0431538 (rank : 58)
Query Neighborhood Hits	197	Target Neighborhood Hits	167	Shared Neighborhood Hits	22
SwissProt Accessions	Q60575, Q9R0B4, Q9WVE5, Q9Z119	Gene names	Kif1b
Domain Architecture
Description	Kinesin-like protein KIF1B.

FKB14_HUMAN
NC score	0.038072 (rank : 289)	θ value	1.38821 (rank : 120)
Query Neighborhood Hits	197	Target Neighborhood Hits	54	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NWM8	Gene names	FKBP14, FKBP22
Domain Architecture
Description	FK506-binding protein 14 precursor (EC 5.2.1.8) (Peptidyl-prolyl cis- trans isomerase) (PPIase) (Rotamase) (22 kDa FK506-binding protein) (FKBP-22).

SPTN4_HUMAN
NC score	0.037722 (rank : 290)	θ value	0.365318 (rank : 92)
Query Neighborhood Hits	197	Target Neighborhood Hits	570	Shared Neighborhood Hits	31
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

S23IP_HUMAN
NC score	0.035829 (rank : 291)	θ value	5.27518 (rank : 167)
Query Neighborhood Hits	197	Target Neighborhood Hits	134	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y6Y8, Q8IXH5, Q9BUK5	Gene names	SEC23IP
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein (p125).

MYCB2_MOUSE
NC score	0.035129 (rank : 292)	θ value	0.813845 (rank : 106)
Query Neighborhood Hits	197	Target Neighborhood Hits	307	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TPH6, Q6PCM8	Gene names	Mycbp2, Pam, Phr1
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

KIF1B_HUMAN
NC score	0.034580 (rank : 293)	θ value	0.21417 (rank : 80)
Query Neighborhood Hits	197	Target Neighborhood Hits	178	Shared Neighborhood Hits	22
SwissProt Accessions	O60333, Q96Q94, Q9BV80, Q9P280	Gene names	KIF1B, KIAA0591, KIAA1448
Domain Architecture
Description	Kinesin-like protein KIF1B (Klp).

MYH9_MOUSE
NC score	0.032838 (rank : 294)	θ value	0.21417 (rank : 81)
Query Neighborhood Hits	197	Target Neighborhood Hits	1829	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

SPTN2_HUMAN
NC score	0.032769 (rank : 295)	θ value	2.36792 (rank : 143)
Query Neighborhood Hits	197	Target Neighborhood Hits	535	Shared Neighborhood Hits	37
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

FKB14_MOUSE
NC score	0.031718 (rank : 296)	θ value	3.0926 (rank : 146)
Query Neighborhood Hits	197	Target Neighborhood Hits	48	Shared Neighborhood Hits	4
SwissProt Accessions	P59024	Gene names	Fkbp14
Domain Architecture
Description	FK506-binding protein 14 precursor (EC 5.2.1.8) (Peptidyl-prolyl cis- trans isomerase) (PPIase) (Rotamase).

MYH9_HUMAN
NC score	0.031603 (rank : 297)	θ value	0.813845 (rank : 107)
Query Neighborhood Hits	197	Target Neighborhood Hits	1762	Shared Neighborhood Hits	51
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

CE005_MOUSE
NC score	0.031429 (rank : 298)	θ value	1.81305 (rank : 125)
Query Neighborhood Hits	197	Target Neighborhood Hits	238	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

MYH11_HUMAN
NC score	0.028580 (rank : 299)	θ value	8.99809 (rank : 190)
Query Neighborhood Hits	197	Target Neighborhood Hits	1806	Shared Neighborhood Hits	49
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

HIP1R_HUMAN
NC score	0.027962 (rank : 300)	θ value	3.0926 (rank : 147)
Query Neighborhood Hits	197	Target Neighborhood Hits	809	Shared Neighborhood Hits	35
SwissProt Accessions	O75146, Q9UED9	Gene names	HIP1R, HIP12, KIAA0655
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related) (Hip 12).

MYH11_MOUSE
NC score	0.027185 (rank : 301)	θ value	8.99809 (rank : 191)
Query Neighborhood Hits	197	Target Neighborhood Hits	1777	Shared Neighborhood Hits	45
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

OSBL1_MOUSE
NC score	0.026633 (rank : 302)	θ value	6.88961 (rank : 179)
Query Neighborhood Hits	197	Target Neighborhood Hits	336	Shared Neighborhood Hits	19
SwissProt Accessions	Q91XL9, O88318, Q3TH97, Q673L8, Q6DFU6	Gene names	Osbpl1a, Orp1, Orp1a
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

UTP20_HUMAN
NC score	0.026256 (rank : 303)	θ value	3.0926 (rank : 150)
Query Neighborhood Hits	197	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	O75691, Q9H3H4	Gene names	UTP20, DRIM
Domain Architecture	No domain graphic available
Description	Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Protein Key-1A6) (Novel nucleolar protein 73) (NNP73).

GOGB1_HUMAN
NC score	0.025866 (rank : 304)	θ value	8.99809 (rank : 186)
Query Neighborhood Hits	197	Target Neighborhood Hits	2297	Shared Neighborhood Hits	58
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

SPTB2_MOUSE
NC score	0.025831 (rank : 305)	θ value	6.88961 (rank : 183)
Query Neighborhood Hits	197	Target Neighborhood Hits	770	Shared Neighborhood Hits	41
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

IWS1_MOUSE
NC score	0.025045 (rank : 306)	θ value	1.81305 (rank : 126)
Query Neighborhood Hits	197	Target Neighborhood Hits	1258	Shared Neighborhood Hits	33
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

VATH_MOUSE
NC score	0.024428 (rank : 307)	θ value	5.27518 (rank : 171)
Query Neighborhood Hits	197	Target Neighborhood Hits	33	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BVE3, Q921X8	Gene names	Atp6v1h
Domain Architecture	No domain graphic available
Description	Vacuolar ATP synthase subunit H (EC 3.6.3.14) (V-ATPase H subunit) (Vacuolar proton pump subunit H).

VATH_HUMAN
NC score	0.024400 (rank : 308)	θ value	5.27518 (rank : 170)
Query Neighborhood Hits	197	Target Neighborhood Hits	35	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UI12, Q6PK44, Q9H3E3, Q9Y300	Gene names	ATP6V1H
Domain Architecture
Description	Vacuolar ATP synthase subunit H (EC 3.6.3.14) (V-ATPase H subunit) (Vacuolar proton pump subunit H) (V-ATPase 50/57 kDa subunits) (Vacuolar proton pump subunit SFD) (VMA13) (Nef-binding protein 1) (NBP1).

ASPP1_MOUSE
NC score	0.023501 (rank : 309)	θ value	8.99809 (rank : 185)
Query Neighborhood Hits	197	Target Neighborhood Hits	1244	Shared Neighborhood Hits	39
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

NUMA1_HUMAN
NC score	0.022898 (rank : 310)	θ value	8.99809 (rank : 192)
Query Neighborhood Hits	197	Target Neighborhood Hits	1523	Shared Neighborhood Hits	48
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

K1802_MOUSE
NC score	0.022270 (rank : 311)	θ value	2.36792 (rank : 136)
Query Neighborhood Hits	197	Target Neighborhood Hits	1596	Shared Neighborhood Hits	36
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

SDC2_MOUSE
NC score	0.021201 (rank : 312)	θ value	8.99809 (rank : 194)
Query Neighborhood Hits	197	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	P43407	Gene names	Sdc2, Hspg1, Synd2
Domain Architecture
Description	Syndecan-2 precursor (SYND2) (Fibroglycan) (Heparan sulfate proteoglycan core protein) (HSPG).

SSFA2_HUMAN
NC score	0.020680 (rank : 313)	θ value	5.27518 (rank : 168)
Query Neighborhood Hits	197	Target Neighborhood Hits	40	Shared Neighborhood Hits	5
SwissProt Accessions	P28290, Q96E36	Gene names	SSFA2, CS1
Domain Architecture	No domain graphic available
Description	Sperm-specific antigen 2 (Cleavage signal-1 protein) (CS-1).

RBBP8_HUMAN
NC score	0.020454 (rank : 314)	θ value	8.99809 (rank : 193)
Query Neighborhood Hits	197	Target Neighborhood Hits	476	Shared Neighborhood Hits	21
SwissProt Accessions	Q99708, O75371	Gene names	RBBP8, CTIP
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 8 (RBBP-8) (CtBP-interacting protein) (CtIP) (Retinoblastoma-interacting protein and myosin-like) (RIM).

TTC28_HUMAN
NC score	0.019486 (rank : 315)	θ value	5.27518 (rank : 169)
Query Neighborhood Hits	197	Target Neighborhood Hits	271	Shared Neighborhood Hits	11
SwissProt Accessions	Q96AY4, O95928, O95929, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5	Gene names	TTC28, KIAA1043
Domain Architecture
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

SOS2_HUMAN
NC score	0.018912 (rank : 316)	θ value	8.99809 (rank : 195)
Query Neighborhood Hits	197	Target Neighborhood Hits	193	Shared Neighborhood Hits	17
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

VIME_HUMAN
NC score	0.015607 (rank : 317)	θ value	1.81305 (rank : 132)
Query Neighborhood Hits	197	Target Neighborhood Hits	706	Shared Neighborhood Hits	28
SwissProt Accessions	P08670, Q15867, Q15868, Q15869, Q6LER9, Q8N850, Q96ML2, Q9NTM3	Gene names	VIM
Domain Architecture
Description	Vimentin.

AP2C_HUMAN
NC score	0.014301 (rank : 318)	θ value	6.88961 (rank : 173)
Query Neighborhood Hits	197	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q92754, O00685, O00730, Q86V30, Q8IVB6, Q9P1X2	Gene names	TFAP2C
Domain Architecture
Description	Transcription factor AP-2 gamma (AP2-gamma) (Activating enhancer- binding protein 2 gamma) (Transcription factor ERF-1).

VIME_MOUSE
NC score	0.013664 (rank : 319)	θ value	4.03905 (rank : 158)
Query Neighborhood Hits	197	Target Neighborhood Hits	716	Shared Neighborhood Hits	28
SwissProt Accessions	P20152, O08704, Q8CCH1	Gene names	Vim
Domain Architecture
Description	Vimentin.

FLNC_HUMAN
NC score	0.011249 (rank : 320)	θ value	6.88961 (rank : 177)
Query Neighborhood Hits	197	Target Neighborhood Hits	116	Shared Neighborhood Hits	7
SwissProt Accessions	Q14315, O95303, Q07985, Q9NS12, Q9NYE5, Q9UMR8, Q9Y503	Gene names	FLNC, ABPL, FLN2
Domain Architecture
Description	Filamin-C (Gamma-filamin) (Filamin-2) (Protein FLNc) (Actin-binding- like protein) (ABP-L) (ABP-280-like protein).

K2C1_HUMAN
NC score	0.010127 (rank : 321)	θ value	4.03905 (rank : 154)
Query Neighborhood Hits	197	Target Neighborhood Hits	624	Shared Neighborhood Hits	20
SwissProt Accessions	P04264, Q14720, Q6GSJ0, Q9H298	Gene names	KRT1, KRTA
Domain Architecture
Description	Keratin, type II cytoskeletal 1 (Cytokeratin-1) (CK-1) (Keratin-1) (K1) (67 kDa cytokeratin) (Hair alpha protein).

TGIF2_MOUSE
NC score	0.010079 (rank : 322)	θ value	8.99809 (rank : 196)
Query Neighborhood Hits	197	Target Neighborhood Hits	127	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C0Y1	Gene names	Tgif2
Domain Architecture	No domain graphic available
Description	Homeobox protein TGIF2 (TGFB-induced factor 2) (5'-TG-3'-interacting factor 2) (TGF(beta)-induced transcription factor 2).

RBP2_MOUSE
NC score	0.009834 (rank : 323)	θ value	5.27518 (rank : 165)
Query Neighborhood Hits	197	Target Neighborhood Hits	232	Shared Neighborhood Hits	7
SwissProt Accessions	Q9ERU9, Q61992, Q8C9K9	Gene names	Ranbp2
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2 (RanBP2).

AKT2_HUMAN
NC score	0.008999 (rank : 324)	θ value	3.0926 (rank : 144)
Query Neighborhood Hits	197	Target Neighborhood Hits	878	Shared Neighborhood Hits	35
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

MLTK_HUMAN
NC score	0.006389 (rank : 325)	θ value	4.03905 (rank : 155)
Query Neighborhood Hits	197	Target Neighborhood Hits	911	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

TLK2_HUMAN
NC score	0.005395 (rank : 326)	θ value	1.06291 (rank : 116)
Query Neighborhood Hits	197	Target Neighborhood Hits	1044	Shared Neighborhood Hits	20
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

MLTK_MOUSE
NC score	0.005029 (rank : 327)	θ value	6.88961 (rank : 178)
Query Neighborhood Hits	197	Target Neighborhood Hits	874	Shared Neighborhood Hits	22
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

EPHA5_HUMAN
NC score	0.004925 (rank : 328)	θ value	6.88961 (rank : 175)
Query Neighborhood Hits	197	Target Neighborhood Hits	1009	Shared Neighborhood Hits	24
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

LIMK1_MOUSE
NC score	0.003822 (rank : 329)	θ value	8.99809 (rank : 187)
Query Neighborhood Hits	197	Target Neighborhood Hits	1008	Shared Neighborhood Hits	36
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

EPHA7_HUMAN
NC score	0.002879 (rank : 330)	θ value	6.88961 (rank : 176)
Query Neighborhood Hits	197	Target Neighborhood Hits	1053	Shared Neighborhood Hits	24
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

TMPS9_MOUSE
NC score	0.001619 (rank : 331)	θ value	6.88961 (rank : 184)
Query Neighborhood Hits	197	Target Neighborhood Hits	296	Shared Neighborhood Hits	5
SwissProt Accessions	P69525	Gene names	Tmprss9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserine protease 1) (Polyserase-I) [Contains: Serase-1; Serase-2; Serase-3].