Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : DYN2_HUMAN

For an explanation of this page, click here

DYN2_HUMAN
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DYN1_HUMAN
θ value	0 (rank : 1)	NC score	0.979150 (rank : 5)
Query Neighborhood Hits	112	Target Neighborhood Hits	216	Shared Neighborhood Hits	67
SwissProt Accessions	Q05193	Gene names	DNM1, DNM
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

DYN1_MOUSE
θ value	0 (rank : 2)	NC score	0.981951 (rank : 4)
Query Neighborhood Hits	112	Target Neighborhood Hits	168	Shared Neighborhood Hits	57
SwissProt Accessions	P39053, Q61358, Q61359, Q61360, Q8JZZ4, Q9CSY7, Q9QXX1	Gene names	Dnm1, Dnm
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

DYN2_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	112	Target Neighborhood Hits	112	Shared Neighborhood Hits	112
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

DYN2_MOUSE
θ value	0 (rank : 4)	NC score	0.996797 (rank : 2)
Query Neighborhood Hits	112	Target Neighborhood Hits	104	Shared Neighborhood Hits	88
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

DYN3_HUMAN
θ value	0 (rank : 5)	NC score	0.985646 (rank : 3)
Query Neighborhood Hits	112	Target Neighborhood Hits	158	Shared Neighborhood Hits	67
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

DNM1L_HUMAN
θ value	6.21357e-126 (rank : 6)	NC score	0.947469 (rank : 7)
Query Neighborhood Hits	112	Target Neighborhood Hits	39	Shared Neighborhood Hits	13
SwissProt Accessions	O00429, O14541, O60709, Q7L6B3, Q8TBT7, Q9BWM1, Q9Y5J2	Gene names	DNM1L, DLP1, DRP1
Domain Architecture	No domain graphic available
Description	Dynamin-1-like protein (EC 3.6.5.5) (Dynamin-like protein) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-related protein 1) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV).

DNM1L_MOUSE
θ value	1.38424e-125 (rank : 7)	NC score	0.947736 (rank : 6)
Query Neighborhood Hits	112	Target Neighborhood Hits	28	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K1M6, Q8BNQ5, Q8BQ64, Q8CGD0, Q8K1A1	Gene names	Dnm1l, Drp1
Domain Architecture	No domain graphic available
Description	Dynamin-1-like protein (EC 3.6.5.5) (Dynamin-related protein 1) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple).

MX1_HUMAN
θ value	9.76566e-63 (rank : 8)	NC score	0.866177 (rank : 8)
Query Neighborhood Hits	112	Target Neighborhood Hits	62	Shared Neighborhood Hits	15
SwissProt Accessions	P20591	Gene names	MX1
Domain Architecture
Description	Interferon-induced GTP-binding protein Mx1 (Interferon-regulated resistance GTP-binding protein MxA) (Interferon-induced protein p78) (IFI-78K).

MX2_MOUSE
θ value	3.14151e-61 (rank : 9)	NC score	0.864745 (rank : 9)
Query Neighborhood Hits	112	Target Neighborhood Hits	62	Shared Neighborhood Hits	13
SwissProt Accessions	Q9WVP9, Q922L4	Gene names	Mx2
Domain Architecture	No domain graphic available
Description	Interferon-induced GTP-binding protein Mx2.

MX1_MOUSE
θ value	1.7238e-59 (rank : 10)	NC score	0.864274 (rank : 10)
Query Neighborhood Hits	112	Target Neighborhood Hits	60	Shared Neighborhood Hits	14
SwissProt Accessions	P09922	Gene names	Mx1
Domain Architecture
Description	Interferon-induced GTP-binding protein Mx1 (Influenza resistance protein).

MX2_HUMAN
θ value	2.48917e-58 (rank : 11)	NC score	0.858573 (rank : 11)
Query Neighborhood Hits	112	Target Neighborhood Hits	71	Shared Neighborhood Hits	16
SwissProt Accessions	P20592	Gene names	MX2
Domain Architecture
Description	Interferon-induced GTP-binding protein Mx2 (Interferon-regulated resistance GTP-binding protein MxB) (p78-related protein).

OPA1_HUMAN
θ value	3.07116e-24 (rank : 12)	NC score	0.690223 (rank : 13)
Query Neighborhood Hits	112	Target Neighborhood Hits	85	Shared Neighborhood Hits	13
SwissProt Accessions	O60313	Gene names	OPA1, KIAA0567
Domain Architecture
Description	Dynamin-like 120 kDa protein, mitochondrial precursor (Optic atrophy protein 1) [Contains: Dynamin-like 120 kDa protein, form S1].

OPA1_MOUSE
θ value	3.07116e-24 (rank : 13)	NC score	0.693121 (rank : 12)
Query Neighborhood Hits	112	Target Neighborhood Hits	79	Shared Neighborhood Hits	13
SwissProt Accessions	P58281, Q3ULA5, Q8BKU7, Q8BLL3, Q8BM08, Q8R3J7	Gene names	Opa1
Domain Architecture
Description	Dynamin-like 120 kDa protein, mitochondrial precursor (Optic atrophy protein 1 homolog) (Large GTP-binding protein) (LargeG) [Contains: Dynamin-like 120 kDa protein, form S1].

CYH3_HUMAN
θ value	0.000602161 (rank : 14)	NC score	0.156055 (rank : 19)
Query Neighborhood Hits	112	Target Neighborhood Hits	137	Shared Neighborhood Hits	35
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

CYH3_MOUSE
θ value	0.000602161 (rank : 15)	NC score	0.152836 (rank : 20)
Query Neighborhood Hits	112	Target Neighborhood Hits	148	Shared Neighborhood Hits	35
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

OGFR_HUMAN
θ value	0.000602161 (rank : 16)	NC score	0.074522 (rank : 40)
Query Neighborhood Hits	112	Target Neighborhood Hits	1582	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

CYH1_HUMAN
θ value	0.00175202 (rank : 17)	NC score	0.158218 (rank : 15)
Query Neighborhood Hits	112	Target Neighborhood Hits	184	Shared Neighborhood Hits	35
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
θ value	0.00175202 (rank : 18)	NC score	0.158130 (rank : 16)
Query Neighborhood Hits	112	Target Neighborhood Hits	176	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

EGR4_HUMAN
θ value	0.00298849 (rank : 19)	NC score	0.016848 (rank : 87)
Query Neighborhood Hits	112	Target Neighborhood Hits	939	Shared Neighborhood Hits	15
SwissProt Accessions	Q05215	Gene names	EGR4
Domain Architecture
Description	Early growth response protein 4 (EGR-4) (AT133).

CNKR2_HUMAN
θ value	0.00390308 (rank : 20)	NC score	0.157017 (rank : 18)
Query Neighborhood Hits	112	Target Neighborhood Hits	197	Shared Neighborhood Hits	36
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	0.00390308 (rank : 21)	NC score	0.157120 (rank : 17)
Query Neighborhood Hits	112	Target Neighborhood Hits	197	Shared Neighborhood Hits	36
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CYH2_HUMAN
θ value	0.00390308 (rank : 22)	NC score	0.149607 (rank : 21)
Query Neighborhood Hits	112	Target Neighborhood Hits	175	Shared Neighborhood Hits	34
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	0.00390308 (rank : 23)	NC score	0.149575 (rank : 22)
Query Neighborhood Hits	112	Target Neighborhood Hits	171	Shared Neighborhood Hits	34
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

PKHA6_HUMAN
θ value	0.00869519 (rank : 24)	NC score	0.138656 (rank : 23)
Query Neighborhood Hits	112	Target Neighborhood Hits	556	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	0.0193708 (rank : 25)	NC score	0.129629 (rank : 25)
Query Neighborhood Hits	112	Target Neighborhood Hits	591	Shared Neighborhood Hits	55
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

RASA2_MOUSE
θ value	0.0193708 (rank : 26)	NC score	0.038201 (rank : 55)
Query Neighborhood Hits	112	Target Neighborhood Hits	159	Shared Neighborhood Hits	15
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

PKHA5_HUMAN
θ value	0.0252991 (rank : 27)	NC score	0.124925 (rank : 27)
Query Neighborhood Hits	112	Target Neighborhood Hits	455	Shared Neighborhood Hits	44
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

RHG25_HUMAN
θ value	0.0252991 (rank : 28)	NC score	0.090986 (rank : 31)
Query Neighborhood Hits	112	Target Neighborhood Hits	550	Shared Neighborhood Hits	48
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_MOUSE
θ value	0.0252991 (rank : 29)	NC score	0.092505 (rank : 30)
Query Neighborhood Hits	112	Target Neighborhood Hits	492	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

CYH4_MOUSE
θ value	0.0330416 (rank : 30)	NC score	0.132628 (rank : 24)
Query Neighborhood Hits	112	Target Neighborhood Hits	134	Shared Neighborhood Hits	34
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

GAK_MOUSE
θ value	0.0563607 (rank : 31)	NC score	0.012195 (rank : 101)
Query Neighborhood Hits	112	Target Neighborhood Hits	964	Shared Neighborhood Hits	15
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

PRRT3_HUMAN
θ value	0.0563607 (rank : 32)	NC score	0.070812 (rank : 42)
Query Neighborhood Hits	112	Target Neighborhood Hits	998	Shared Neighborhood Hits	40
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

CYH4_HUMAN
θ value	0.0736092 (rank : 33)	NC score	0.127881 (rank : 26)
Query Neighborhood Hits	112	Target Neighborhood Hits	135	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

SON_HUMAN
θ value	0.0961366 (rank : 34)	NC score	0.047982 (rank : 52)
Query Neighborhood Hits	112	Target Neighborhood Hits	1568	Shared Neighborhood Hits	46
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

K2C5_MOUSE
θ value	0.125558 (rank : 35)	NC score	0.023422 (rank : 68)
Query Neighborhood Hits	112	Target Neighborhood Hits	505	Shared Neighborhood Hits	19
SwissProt Accessions	Q922U2, Q920F2	Gene names	Krt5, Krt2-5
Domain Architecture	No domain graphic available
Description	Keratin, type II cytoskeletal 5 (Cytokeratin-5) (CK-5) (Keratin-5) (K5).

CEL_HUMAN
θ value	0.163984 (rank : 36)	NC score	0.063139 (rank : 43)
Query Neighborhood Hits	112	Target Neighborhood Hits	896	Shared Neighborhood Hits	37
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

RGS3_MOUSE
θ value	0.163984 (rank : 37)	NC score	0.032697 (rank : 59)
Query Neighborhood Hits	112	Target Neighborhood Hits	1621	Shared Neighborhood Hits	50
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

SEM6C_MOUSE
θ value	0.163984 (rank : 38)	NC score	0.018062 (rank : 85)
Query Neighborhood Hits	112	Target Neighborhood Hits	352	Shared Neighborhood Hits	22
SwissProt Accessions	Q9WTM3	Gene names	Sema6c, Semay
Domain Architecture
Description	Semaphorin-6C precursor (Semaphorin Y) (Sema Y).

TARA_MOUSE
θ value	0.163984 (rank : 39)	NC score	0.072667 (rank : 41)
Query Neighborhood Hits	112	Target Neighborhood Hits	1133	Shared Neighborhood Hits	59
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

MRIP_HUMAN
θ value	0.21417 (rank : 40)	NC score	0.078423 (rank : 37)
Query Neighborhood Hits	112	Target Neighborhood Hits	578	Shared Neighborhood Hits	44
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

COGA1_HUMAN
θ value	0.365318 (rank : 41)	NC score	0.027073 (rank : 66)
Query Neighborhood Hits	112	Target Neighborhood Hits	345	Shared Neighborhood Hits	22
SwissProt Accessions	Q07092	Gene names	COL16A1
Domain Architecture
Description	Collagen alpha-1(XVI) chain precursor.

MAGE1_HUMAN
θ value	0.47712 (rank : 42)	NC score	0.022969 (rank : 71)
Query Neighborhood Hits	112	Target Neighborhood Hits	1389	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

FOXJ2_HUMAN
θ value	0.62314 (rank : 43)	NC score	0.016545 (rank : 90)
Query Neighborhood Hits	112	Target Neighborhood Hits	239	Shared Neighborhood Hits	15
SwissProt Accessions	Q9P0K8, Q96PS9, Q9NSN5	Gene names	FOXJ2, FHX
Domain Architecture
Description	Forkhead box protein J2 (Fork head homologous X).

FYCO1_HUMAN
θ value	0.62314 (rank : 44)	NC score	0.021759 (rank : 75)
Query Neighborhood Hits	112	Target Neighborhood Hits	1149	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

MRIP_MOUSE
θ value	0.62314 (rank : 45)	NC score	0.077829 (rank : 38)
Query Neighborhood Hits	112	Target Neighborhood Hits	569	Shared Neighborhood Hits	45
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

PKHA1_HUMAN
θ value	0.62314 (rank : 46)	NC score	0.083463 (rank : 34)
Query Neighborhood Hits	112	Target Neighborhood Hits	127	Shared Neighborhood Hits	26
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	0.62314 (rank : 47)	NC score	0.082373 (rank : 35)
Query Neighborhood Hits	112	Target Neighborhood Hits	120	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PLEK_HUMAN
θ value	0.62314 (rank : 48)	NC score	0.086463 (rank : 32)
Query Neighborhood Hits	112	Target Neighborhood Hits	110	Shared Neighborhood Hits	28
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

CSKI1_MOUSE
θ value	0.813845 (rank : 49)	NC score	0.019466 (rank : 82)
Query Neighborhood Hits	112	Target Neighborhood Hits	1031	Shared Neighborhood Hits	35
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

K2C5_HUMAN
θ value	0.813845 (rank : 50)	NC score	0.019655 (rank : 81)
Query Neighborhood Hits	112	Target Neighborhood Hits	506	Shared Neighborhood Hits	18
SwissProt Accessions	P13647, Q6PI71, Q6UBJ0, Q8TA91	Gene names	KRT5
Domain Architecture
Description	Keratin, type II cytoskeletal 5 (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (58 kDa cytokeratin).

LCP2_HUMAN
θ value	0.813845 (rank : 51)	NC score	0.040580 (rank : 54)
Query Neighborhood Hits	112	Target Neighborhood Hits	531	Shared Neighborhood Hits	32
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

MYO15_MOUSE
θ value	0.813845 (rank : 52)	NC score	0.013450 (rank : 99)
Query Neighborhood Hits	112	Target Neighborhood Hits	467	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

CNKR1_HUMAN
θ value	1.06291 (rank : 53)	NC score	0.169156 (rank : 14)
Query Neighborhood Hits	112	Target Neighborhood Hits	154	Shared Neighborhood Hits	40
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

RPGF1_HUMAN
θ value	1.06291 (rank : 54)	NC score	0.014918 (rank : 95)
Query Neighborhood Hits	112	Target Neighborhood Hits	262	Shared Neighborhood Hits	8
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

COA1_HUMAN
θ value	1.38821 (rank : 55)	NC score	0.020080 (rank : 80)
Query Neighborhood Hits	112	Target Neighborhood Hits	49	Shared Neighborhood Hits	5
SwissProt Accessions	Q13085	Gene names	ACACA, ACAC, ACC1, ACCA
Domain Architecture
Description	Acetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)].

PKHA4_HUMAN
θ value	1.38821 (rank : 56)	NC score	0.104386 (rank : 28)
Query Neighborhood Hits	112	Target Neighborhood Hits	283	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_MOUSE
θ value	1.38821 (rank : 57)	NC score	0.100218 (rank : 29)
Query Neighborhood Hits	112	Target Neighborhood Hits	202	Shared Neighborhood Hits	43
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHB1_HUMAN
θ value	1.38821 (rank : 58)	NC score	0.086101 (rank : 33)
Query Neighborhood Hits	112	Target Neighborhood Hits	46	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

ROCK1_HUMAN
θ value	1.38821 (rank : 59)	NC score	0.011683 (rank : 102)
Query Neighborhood Hits	112	Target Neighborhood Hits	2000	Shared Neighborhood Hits	34
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ROCK1_MOUSE
θ value	1.38821 (rank : 60)	NC score	0.011274 (rank : 103)
Query Neighborhood Hits	112	Target Neighborhood Hits	2126	Shared Neighborhood Hits	36
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

ZN516_MOUSE
θ value	1.38821 (rank : 61)	NC score	0.007647 (rank : 110)
Query Neighborhood Hits	112	Target Neighborhood Hits	1197	Shared Neighborhood Hits	34
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

CO5A2_HUMAN
θ value	1.81305 (rank : 62)	NC score	0.014873 (rank : 96)
Query Neighborhood Hits	112	Target Neighborhood Hits	760	Shared Neighborhood Hits	29
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

FOXN1_MOUSE
θ value	1.81305 (rank : 63)	NC score	0.017333 (rank : 86)
Query Neighborhood Hits	112	Target Neighborhood Hits	300	Shared Neighborhood Hits	16
SwissProt Accessions	Q61575	Gene names	Foxn1, Fkh19, Hfh11, Whn
Domain Architecture
Description	Forkhead box protein N1 (Transcription factor winged-helix nude) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HNF-3/forkhead homolog 11) (HFH-11).

GPTC8_HUMAN
θ value	1.81305 (rank : 64)	NC score	0.020125 (rank : 79)
Query Neighborhood Hits	112	Target Neighborhood Hits	366	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UKJ3, O60300	Gene names	GPATC8, KIAA0553
Domain Architecture	No domain graphic available
Description	G patch domain-containing protein 8.

K2C6B_MOUSE
θ value	1.81305 (rank : 65)	NC score	0.020651 (rank : 78)
Query Neighborhood Hits	112	Target Neighborhood Hits	506	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Z331	Gene names	Krt6b, K6-beta, Krt2-6b
Domain Architecture	No domain graphic available
Description	Keratin, type II cytoskeletal 6B (Cytokeratin-6B) (CK 6B) (K6b keratin) (Keratin-6 beta) (mK6-beta).

K2C8_MOUSE
θ value	1.81305 (rank : 66)	NC score	0.014767 (rank : 97)
Query Neighborhood Hits	112	Target Neighborhood Hits	576	Shared Neighborhood Hits	21
SwissProt Accessions	P11679, Q3KQK5, Q3TGI1, Q3TJE1, Q3TKY7, Q61463, Q61518, Q61519	Gene names	Krt8, Krt2-8
Domain Architecture
Description	Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Cytokeratin endo A).

MAP1A_HUMAN
θ value	1.81305 (rank : 67)	NC score	0.021456 (rank : 76)
Query Neighborhood Hits	112	Target Neighborhood Hits	1626	Shared Neighborhood Hits	46
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

PKHB1_MOUSE
θ value	1.81305 (rank : 68)	NC score	0.078993 (rank : 36)
Query Neighborhood Hits	112	Target Neighborhood Hits	47	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

PYR1_HUMAN
θ value	1.81305 (rank : 69)	NC score	0.014987 (rank : 94)
Query Neighborhood Hits	112	Target Neighborhood Hits	119	Shared Neighborhood Hits	8
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].

TIAM1_HUMAN
θ value	1.81305 (rank : 70)	NC score	0.023262 (rank : 69)
Query Neighborhood Hits	112	Target Neighborhood Hits	225	Shared Neighborhood Hits	15
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

BCL9_HUMAN
θ value	2.36792 (rank : 71)	NC score	0.051675 (rank : 49)
Query Neighborhood Hits	112	Target Neighborhood Hits	1008	Shared Neighborhood Hits	38
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

MLL2_HUMAN
θ value	2.36792 (rank : 72)	NC score	0.031426 (rank : 60)
Query Neighborhood Hits	112	Target Neighborhood Hits	1788	Shared Neighborhood Hits	54
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

MLL3_HUMAN
θ value	2.36792 (rank : 73)	NC score	0.030496 (rank : 61)
Query Neighborhood Hits	112	Target Neighborhood Hits	1644	Shared Neighborhood Hits	43
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

MLL3_MOUSE
θ value	2.36792 (rank : 74)	NC score	0.029615 (rank : 62)
Query Neighborhood Hits	112	Target Neighborhood Hits	1399	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

NRX2A_HUMAN
θ value	2.36792 (rank : 75)	NC score	0.022288 (rank : 73)
Query Neighborhood Hits	112	Target Neighborhood Hits	614	Shared Neighborhood Hits	27
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

NRX2B_HUMAN
θ value	2.36792 (rank : 76)	NC score	0.033134 (rank : 58)
Query Neighborhood Hits	112	Target Neighborhood Hits	481	Shared Neighborhood Hits	25
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

PEX1_HUMAN
θ value	2.36792 (rank : 77)	NC score	0.006373 (rank : 113)
Query Neighborhood Hits	112	Target Neighborhood Hits	98	Shared Neighborhood Hits	4
SwissProt Accessions	O43933, Q96S71, Q96S72, Q96S73, Q99994	Gene names	PEX1
Domain Architecture
Description	Peroxisome biogenesis factor 1 (Peroxin-1) (Peroxisome biogenesis disorder protein 1).

MYO10_HUMAN
θ value	3.0926 (rank : 78)	NC score	0.028077 (rank : 64)
Query Neighborhood Hits	112	Target Neighborhood Hits	920	Shared Neighborhood Hits	47
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

NCOA6_HUMAN
θ value	3.0926 (rank : 79)	NC score	0.041384 (rank : 53)
Query Neighborhood Hits	112	Target Neighborhood Hits	1202	Shared Neighborhood Hits	43
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

NSD1_MOUSE
θ value	3.0926 (rank : 80)	NC score	0.018331 (rank : 84)
Query Neighborhood Hits	112	Target Neighborhood Hits	472	Shared Neighborhood Hits	23
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

PLEK_MOUSE
θ value	3.0926 (rank : 81)	NC score	0.074897 (rank : 39)
Query Neighborhood Hits	112	Target Neighborhood Hits	109	Shared Neighborhood Hits	27
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

ULK1_MOUSE
θ value	3.0926 (rank : 82)	NC score	0.005273 (rank : 114)
Query Neighborhood Hits	112	Target Neighborhood Hits	1214	Shared Neighborhood Hits	29
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

ASPP2_HUMAN
θ value	4.03905 (rank : 83)	NC score	0.010597 (rank : 105)
Query Neighborhood Hits	112	Target Neighborhood Hits	1156	Shared Neighborhood Hits	40
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

EPN1_MOUSE
θ value	4.03905 (rank : 84)	NC score	0.027460 (rank : 65)
Query Neighborhood Hits	112	Target Neighborhood Hits	240	Shared Neighborhood Hits	27
SwissProt Accessions	Q80VP1, O70446	Gene names	Epn1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (Intersectin-EH-binding protein 1) (Ibp1).

K2C6A_HUMAN
θ value	4.03905 (rank : 85)	NC score	0.016616 (rank : 88)
Query Neighborhood Hits	112	Target Neighborhood Hits	505	Shared Neighborhood Hits	20
SwissProt Accessions	P02538, Q6NT67, Q96CL4	Gene names	KRT6A, K6A
Domain Architecture
Description	Keratin, type II cytoskeletal 6A (Cytokeratin-6A) (CK 6A) (K6a keratin).

K2C6C_HUMAN
θ value	4.03905 (rank : 86)	NC score	0.016605 (rank : 89)
Query Neighborhood Hits	112	Target Neighborhood Hits	503	Shared Neighborhood Hits	20
SwissProt Accessions	P48666	Gene names	KRT6C
Domain Architecture
Description	Keratin, type II cytoskeletal 6C (Cytokeratin-6C) (CK 6C) (K6c keratin).

UFO_HUMAN
θ value	4.03905 (rank : 87)	NC score	-0.001027 (rank : 119)
Query Neighborhood Hits	112	Target Neighborhood Hits	981	Shared Neighborhood Hits	10
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

ANK2_HUMAN
θ value	5.27518 (rank : 88)	NC score	0.013953 (rank : 98)
Query Neighborhood Hits	112	Target Neighborhood Hits	1615	Shared Neighborhood Hits	42
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

K2C8_HUMAN
θ value	5.27518 (rank : 89)	NC score	0.015134 (rank : 92)
Query Neighborhood Hits	112	Target Neighborhood Hits	593	Shared Neighborhood Hits	22
SwissProt Accessions	P05787, Q14099, Q14716, Q14717, Q53GJ0, Q6DHW5, Q6GMY0, Q96J60	Gene names	KRT8, CYK8
Domain Architecture
Description	Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8).

NFIC_MOUSE
θ value	5.27518 (rank : 90)	NC score	0.009841 (rank : 106)
Query Neighborhood Hits	112	Target Neighborhood Hits	66	Shared Neighborhood Hits	5
SwissProt Accessions	P70255, O09072, P70256, Q3U2I9, Q99MA3, Q99MA4, Q99MA5, Q99MA6, Q99MA7, Q99MA8, Q9R1G3	Gene names	Nfic
Domain Architecture
Description	Nuclear factor 1 C-type (Nuclear factor 1/C) (NF1-C) (NFI-C) (NF-I/C) (CCAAT-box-binding transcription factor) (CTF) (TGGCA-binding protein).

PER2_MOUSE
θ value	5.27518 (rank : 91)	NC score	0.006746 (rank : 111)
Query Neighborhood Hits	112	Target Neighborhood Hits	325	Shared Neighborhood Hits	6
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

SON_MOUSE
θ value	5.27518 (rank : 92)	NC score	0.029076 (rank : 63)
Query Neighborhood Hits	112	Target Neighborhood Hits	957	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

TITIN_HUMAN
θ value	5.27518 (rank : 93)	NC score	0.004981 (rank : 115)
Query Neighborhood Hits	112	Target Neighborhood Hits	2923	Shared Neighborhood Hits	47
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

TRPS1_HUMAN
θ value	5.27518 (rank : 94)	NC score	0.012416 (rank : 100)
Query Neighborhood Hits	112	Target Neighborhood Hits	539	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UHF7, Q9NWE1, Q9UHH6	Gene names	TRPS1
Domain Architecture
Description	Zinc finger transcription factor Trps1 (Zinc finger protein GC79) (Tricho-rhino-phalangeal syndrome type I protein).

UGGG1_MOUSE
θ value	5.27518 (rank : 95)	NC score	0.021807 (rank : 74)
Query Neighborhood Hits	112	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P5E4, Q6NV70	Gene names	Ugcgl1, Gt, Uggt, Ugt1, Ugtr
Domain Architecture	No domain graphic available
Description	UDP-glucose:glycoprotein glucosyltransferase 1 precursor (EC 2.4.1.-) (UDP-glucose ceramide glucosyltransferase-like 1) (UDP-- Glc:glycoprotein glucosyltransferase).

CD2L2_HUMAN
θ value	6.88961 (rank : 96)	NC score	-0.000220 (rank : 118)
Query Neighborhood Hits	112	Target Neighborhood Hits	1439	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

CDN1C_MOUSE
θ value	6.88961 (rank : 97)	NC score	0.025577 (rank : 67)
Query Neighborhood Hits	112	Target Neighborhood Hits	161	Shared Neighborhood Hits	15
SwissProt Accessions	P49919	Gene names	Cdkn1c, Kip2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57KIP2).

CSKI1_HUMAN
θ value	6.88961 (rank : 98)	NC score	0.021044 (rank : 77)
Query Neighborhood Hits	112	Target Neighborhood Hits	997	Shared Neighborhood Hits	42
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

FA47B_HUMAN
θ value	6.88961 (rank : 99)	NC score	0.018547 (rank : 83)
Query Neighborhood Hits	112	Target Neighborhood Hits	431	Shared Neighborhood Hits	24
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

MYO15_HUMAN
θ value	6.88961 (rank : 100)	NC score	0.022309 (rank : 72)
Query Neighborhood Hits	112	Target Neighborhood Hits	671	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

REXO1_MOUSE
θ value	6.88961 (rank : 101)	NC score	0.008972 (rank : 108)
Query Neighborhood Hits	112	Target Neighborhood Hits	166	Shared Neighborhood Hits	10
SwissProt Accessions	Q7TT28, Q3UMP1, Q69ZR0, Q6NSQ6, Q6PI95, Q9DA29	Gene names	Rexo1, Kiaa1138, Tceb3bp1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Transcription elongation factor B polypeptide 3-binding protein 1).

TRPS1_MOUSE
θ value	6.88961 (rank : 102)	NC score	0.011109 (rank : 104)
Query Neighborhood Hits	112	Target Neighborhood Hits	609	Shared Neighborhood Hits	7
SwissProt Accessions	Q925H1	Gene names	Trps1
Domain Architecture
Description	Zinc finger transcription factor Trps1.

ULK1_HUMAN
θ value	6.88961 (rank : 103)	NC score	0.001982 (rank : 117)
Query Neighborhood Hits	112	Target Neighborhood Hits	1121	Shared Neighborhood Hits	23
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

GIMA4_HUMAN
θ value	8.99809 (rank : 104)	NC score	0.009144 (rank : 107)
Query Neighborhood Hits	112	Target Neighborhood Hits	217	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NUV9	Gene names	GIMAP4, IAN1, IMAP4
Domain Architecture
Description	GTPase, IMAP family member 4 (Immunity-associated protein 4) (Immunity-associated nucleotide 1 protein) (hIAN1).

K2C6A_MOUSE
θ value	8.99809 (rank : 105)	NC score	0.015044 (rank : 93)
Query Neighborhood Hits	112	Target Neighborhood Hits	481	Shared Neighborhood Hits	15
SwissProt Accessions	P50446, Q9Z332	Gene names	Krt6a, Ker2, Krt2-6, Krt2-6a, Krt6
Domain Architecture
Description	Keratin, type II cytoskeletal 6A (Cytokeratin-6A) (CK 6A) (K6a keratin) (Keratin-6 alpha) (mK6-alpha).

LAMA3_HUMAN
θ value	8.99809 (rank : 106)	NC score	0.006430 (rank : 112)
Query Neighborhood Hits	112	Target Neighborhood Hits	760	Shared Neighborhood Hits	17
SwissProt Accessions	Q16787, Q13679, Q13680, Q96TG0	Gene names	LAMA3
Domain Architecture
Description	Laminin alpha-3 chain precursor (Epiligrin 170 kDa subunit) (E170) (Nicein subunit alpha).

NACAM_MOUSE
θ value	8.99809 (rank : 107)	NC score	0.023178 (rank : 70)
Query Neighborhood Hits	112	Target Neighborhood Hits	1866	Shared Neighborhood Hits	44
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

NCOA6_MOUSE
θ value	8.99809 (rank : 108)	NC score	0.034737 (rank : 57)
Query Neighborhood Hits	112	Target Neighborhood Hits	1076	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

PICAL_HUMAN
θ value	8.99809 (rank : 109)	NC score	0.008516 (rank : 109)
Query Neighborhood Hits	112	Target Neighborhood Hits	57	Shared Neighborhood Hits	4
SwissProt Accessions	Q13492, O60700, Q86XZ9	Gene names	PICALM, CALM
Domain Architecture
Description	Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein).

TARA_HUMAN
θ value	8.99809 (rank : 110)	NC score	0.036630 (rank : 56)
Query Neighborhood Hits	112	Target Neighborhood Hits	1626	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TBX6_MOUSE
θ value	8.99809 (rank : 111)	NC score	0.002304 (rank : 116)
Query Neighborhood Hits	112	Target Neighborhood Hits	54	Shared Neighborhood Hits	2
SwissProt Accessions	P70327	Gene names	Tbx6
Domain Architecture
Description	T-box transcription factor TBX6 (T-box protein 6).

TIAM1_MOUSE
θ value	8.99809 (rank : 112)	NC score	0.016512 (rank : 91)
Query Neighborhood Hits	112	Target Neighborhood Hits	205	Shared Neighborhood Hits	16
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

BIG1_HUMAN
θ value	θ > 10 (rank : 113)	NC score	0.052141 (rank : 48)
Query Neighborhood Hits	112	Target Neighborhood Hits	76	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

BIG2_HUMAN
θ value	θ > 10 (rank : 114)	NC score	0.052593 (rank : 46)
Query Neighborhood Hits	112	Target Neighborhood Hits	66	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

GBF1_HUMAN
θ value	θ > 10 (rank : 115)	NC score	0.056489 (rank : 45)
Query Neighborhood Hits	112	Target Neighborhood Hits	142	Shared Neighborhood Hits	17
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

IQEC3_MOUSE
θ value	θ > 10 (rank : 116)	NC score	0.050587 (rank : 51)
Query Neighborhood Hits	112	Target Neighborhood Hits	274	Shared Neighborhood Hits	22
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

PKHA2_MOUSE
θ value	θ > 10 (rank : 117)	NC score	0.051315 (rank : 50)
Query Neighborhood Hits	112	Target Neighborhood Hits	116	Shared Neighborhood Hits	28
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PSD3_HUMAN
θ value	θ > 10 (rank : 118)	NC score	0.058312 (rank : 44)
Query Neighborhood Hits	112	Target Neighborhood Hits	75	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

PSD4_HUMAN
θ value	θ > 10 (rank : 119)	NC score	0.052438 (rank : 47)
Query Neighborhood Hits	112	Target Neighborhood Hits	178	Shared Neighborhood Hits	24
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

Hits sorted by NC score

DYN2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	112	Target Neighborhood Hits	112	Shared Neighborhood Hits	112
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

DYN2_MOUSE
NC score	0.996797 (rank : 2)	θ value	0 (rank : 4)
Query Neighborhood Hits	112	Target Neighborhood Hits	104	Shared Neighborhood Hits	88
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

DYN3_HUMAN
NC score	0.985646 (rank : 3)	θ value	0 (rank : 5)
Query Neighborhood Hits	112	Target Neighborhood Hits	158	Shared Neighborhood Hits	67
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

DYN1_MOUSE
NC score	0.981951 (rank : 4)	θ value	0 (rank : 2)
Query Neighborhood Hits	112	Target Neighborhood Hits	168	Shared Neighborhood Hits	57
SwissProt Accessions	P39053, Q61358, Q61359, Q61360, Q8JZZ4, Q9CSY7, Q9QXX1	Gene names	Dnm1, Dnm
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

DYN1_HUMAN
NC score	0.979150 (rank : 5)	θ value	0 (rank : 1)
Query Neighborhood Hits	112	Target Neighborhood Hits	216	Shared Neighborhood Hits	67
SwissProt Accessions	Q05193	Gene names	DNM1, DNM
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

DNM1L_MOUSE
NC score	0.947736 (rank : 6)	θ value	1.38424e-125 (rank : 7)
Query Neighborhood Hits	112	Target Neighborhood Hits	28	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K1M6, Q8BNQ5, Q8BQ64, Q8CGD0, Q8K1A1	Gene names	Dnm1l, Drp1
Domain Architecture	No domain graphic available
Description	Dynamin-1-like protein (EC 3.6.5.5) (Dynamin-related protein 1) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple).

DNM1L_HUMAN
NC score	0.947469 (rank : 7)	θ value	6.21357e-126 (rank : 6)
Query Neighborhood Hits	112	Target Neighborhood Hits	39	Shared Neighborhood Hits	13
SwissProt Accessions	O00429, O14541, O60709, Q7L6B3, Q8TBT7, Q9BWM1, Q9Y5J2	Gene names	DNM1L, DLP1, DRP1
Domain Architecture	No domain graphic available
Description	Dynamin-1-like protein (EC 3.6.5.5) (Dynamin-like protein) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-related protein 1) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV).

MX1_HUMAN
NC score	0.866177 (rank : 8)	θ value	9.76566e-63 (rank : 8)
Query Neighborhood Hits	112	Target Neighborhood Hits	62	Shared Neighborhood Hits	15
SwissProt Accessions	P20591	Gene names	MX1
Domain Architecture
Description	Interferon-induced GTP-binding protein Mx1 (Interferon-regulated resistance GTP-binding protein MxA) (Interferon-induced protein p78) (IFI-78K).

MX2_MOUSE
NC score	0.864745 (rank : 9)	θ value	3.14151e-61 (rank : 9)
Query Neighborhood Hits	112	Target Neighborhood Hits	62	Shared Neighborhood Hits	13
SwissProt Accessions	Q9WVP9, Q922L4	Gene names	Mx2
Domain Architecture	No domain graphic available
Description	Interferon-induced GTP-binding protein Mx2.

MX1_MOUSE
NC score	0.864274 (rank : 10)	θ value	1.7238e-59 (rank : 10)
Query Neighborhood Hits	112	Target Neighborhood Hits	60	Shared Neighborhood Hits	14
SwissProt Accessions	P09922	Gene names	Mx1
Domain Architecture
Description	Interferon-induced GTP-binding protein Mx1 (Influenza resistance protein).

MX2_HUMAN
NC score	0.858573 (rank : 11)	θ value	2.48917e-58 (rank : 11)
Query Neighborhood Hits	112	Target Neighborhood Hits	71	Shared Neighborhood Hits	16
SwissProt Accessions	P20592	Gene names	MX2
Domain Architecture
Description	Interferon-induced GTP-binding protein Mx2 (Interferon-regulated resistance GTP-binding protein MxB) (p78-related protein).

OPA1_MOUSE
NC score	0.693121 (rank : 12)	θ value	3.07116e-24 (rank : 13)
Query Neighborhood Hits	112	Target Neighborhood Hits	79	Shared Neighborhood Hits	13
SwissProt Accessions	P58281, Q3ULA5, Q8BKU7, Q8BLL3, Q8BM08, Q8R3J7	Gene names	Opa1
Domain Architecture
Description	Dynamin-like 120 kDa protein, mitochondrial precursor (Optic atrophy protein 1 homolog) (Large GTP-binding protein) (LargeG) [Contains: Dynamin-like 120 kDa protein, form S1].

OPA1_HUMAN
NC score	0.690223 (rank : 13)	θ value	3.07116e-24 (rank : 12)
Query Neighborhood Hits	112	Target Neighborhood Hits	85	Shared Neighborhood Hits	13
SwissProt Accessions	O60313	Gene names	OPA1, KIAA0567
Domain Architecture
Description	Dynamin-like 120 kDa protein, mitochondrial precursor (Optic atrophy protein 1) [Contains: Dynamin-like 120 kDa protein, form S1].

CNKR1_HUMAN
NC score	0.169156 (rank : 14)	θ value	1.06291 (rank : 53)
Query Neighborhood Hits	112	Target Neighborhood Hits	154	Shared Neighborhood Hits	40
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CYH1_HUMAN
NC score	0.158218 (rank : 15)	θ value	0.00175202 (rank : 17)
Query Neighborhood Hits	112	Target Neighborhood Hits	184	Shared Neighborhood Hits	35
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
NC score	0.158130 (rank : 16)	θ value	0.00175202 (rank : 18)
Query Neighborhood Hits	112	Target Neighborhood Hits	176	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

CNKR2_MOUSE
NC score	0.157120 (rank : 17)	θ value	0.00390308 (rank : 21)
Query Neighborhood Hits	112	Target Neighborhood Hits	197	Shared Neighborhood Hits	36
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.157017 (rank : 18)	θ value	0.00390308 (rank : 20)
Query Neighborhood Hits	112	Target Neighborhood Hits	197	Shared Neighborhood Hits	36
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CYH3_HUMAN
NC score	0.156055 (rank : 19)	θ value	0.000602161 (rank : 14)
Query Neighborhood Hits	112	Target Neighborhood Hits	137	Shared Neighborhood Hits	35
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

CYH3_MOUSE
NC score	0.152836 (rank : 20)	θ value	0.000602161 (rank : 15)
Query Neighborhood Hits	112	Target Neighborhood Hits	148	Shared Neighborhood Hits	35
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

CYH2_HUMAN
NC score	0.149607 (rank : 21)	θ value	0.00390308 (rank : 22)
Query Neighborhood Hits	112	Target Neighborhood Hits	175	Shared Neighborhood Hits	34
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
NC score	0.149575 (rank : 22)	θ value	0.00390308 (rank : 23)
Query Neighborhood Hits	112	Target Neighborhood Hits	171	Shared Neighborhood Hits	34
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

PKHA6_HUMAN
NC score	0.138656 (rank : 23)	θ value	0.00869519 (rank : 24)
Query Neighborhood Hits	112	Target Neighborhood Hits	556	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

CYH4_MOUSE
NC score	0.132628 (rank : 24)	θ value	0.0330416 (rank : 30)
Query Neighborhood Hits	112	Target Neighborhood Hits	134	Shared Neighborhood Hits	34
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

PKHA6_MOUSE
NC score	0.129629 (rank : 25)	θ value	0.0193708 (rank : 25)
Query Neighborhood Hits	112	Target Neighborhood Hits	591	Shared Neighborhood Hits	55
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

CYH4_HUMAN
NC score	0.127881 (rank : 26)	θ value	0.0736092 (rank : 33)
Query Neighborhood Hits	112	Target Neighborhood Hits	135	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

PKHA5_HUMAN
NC score	0.124925 (rank : 27)	θ value	0.0252991 (rank : 27)
Query Neighborhood Hits	112	Target Neighborhood Hits	455	Shared Neighborhood Hits	44
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA4_HUMAN
NC score	0.104386 (rank : 28)	θ value	1.38821 (rank : 56)
Query Neighborhood Hits	112	Target Neighborhood Hits	283	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_MOUSE
NC score	0.100218 (rank : 29)	θ value	1.38821 (rank : 57)
Query Neighborhood Hits	112	Target Neighborhood Hits	202	Shared Neighborhood Hits	43
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

RHG25_MOUSE
NC score	0.092505 (rank : 30)	θ value	0.0252991 (rank : 29)
Query Neighborhood Hits	112	Target Neighborhood Hits	492	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_HUMAN
NC score	0.090986 (rank : 31)	θ value	0.0252991 (rank : 28)
Query Neighborhood Hits	112	Target Neighborhood Hits	550	Shared Neighborhood Hits	48
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

PLEK_HUMAN
NC score	0.086463 (rank : 32)	θ value	0.62314 (rank : 48)
Query Neighborhood Hits	112	Target Neighborhood Hits	110	Shared Neighborhood Hits	28
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PKHB1_HUMAN
NC score	0.086101 (rank : 33)	θ value	1.38821 (rank : 58)
Query Neighborhood Hits	112	Target Neighborhood Hits	46	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

PKHA1_HUMAN
NC score	0.083463 (rank : 34)	θ value	0.62314 (rank : 46)
Query Neighborhood Hits	112	Target Neighborhood Hits	127	Shared Neighborhood Hits	26
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
NC score	0.082373 (rank : 35)	θ value	0.62314 (rank : 47)
Query Neighborhood Hits	112	Target Neighborhood Hits	120	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHB1_MOUSE
NC score	0.078993 (rank : 36)	θ value	1.81305 (rank : 68)
Query Neighborhood Hits	112	Target Neighborhood Hits	47	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

MRIP_HUMAN
NC score	0.078423 (rank : 37)	θ value	0.21417 (rank : 40)
Query Neighborhood Hits	112	Target Neighborhood Hits	578	Shared Neighborhood Hits	44
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

MRIP_MOUSE
NC score	0.077829 (rank : 38)	θ value	0.62314 (rank : 45)
Query Neighborhood Hits	112	Target Neighborhood Hits	569	Shared Neighborhood Hits	45
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

PLEK_MOUSE
NC score	0.074897 (rank : 39)	θ value	3.0926 (rank : 81)
Query Neighborhood Hits	112	Target Neighborhood Hits	109	Shared Neighborhood Hits	27
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

OGFR_HUMAN
NC score	0.074522 (rank : 40)	θ value	0.000602161 (rank : 16)
Query Neighborhood Hits	112	Target Neighborhood Hits	1582	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

TARA_MOUSE
NC score	0.072667 (rank : 41)	θ value	0.163984 (rank : 39)
Query Neighborhood Hits	112	Target Neighborhood Hits	1133	Shared Neighborhood Hits	59
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

PRRT3_HUMAN
NC score	0.070812 (rank : 42)	θ value	0.0563607 (rank : 32)
Query Neighborhood Hits	112	Target Neighborhood Hits	998	Shared Neighborhood Hits	40
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

CEL_HUMAN
NC score	0.063139 (rank : 43)	θ value	0.163984 (rank : 36)
Query Neighborhood Hits	112	Target Neighborhood Hits	896	Shared Neighborhood Hits	37
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

PSD3_HUMAN
NC score	0.058312 (rank : 44)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	112	Target Neighborhood Hits	75	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

GBF1_HUMAN
NC score	0.056489 (rank : 45)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	112	Target Neighborhood Hits	142	Shared Neighborhood Hits	17
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

BIG2_HUMAN
NC score	0.052593 (rank : 46)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	112	Target Neighborhood Hits	66	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

PSD4_HUMAN
NC score	0.052438 (rank : 47)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	112	Target Neighborhood Hits	178	Shared Neighborhood Hits	24
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

BIG1_HUMAN
NC score	0.052141 (rank : 48)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	112	Target Neighborhood Hits	76	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

BCL9_HUMAN
NC score	0.051675 (rank : 49)	θ value	2.36792 (rank : 71)
Query Neighborhood Hits	112	Target Neighborhood Hits	1008	Shared Neighborhood Hits	38
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

PKHA2_MOUSE
NC score	0.051315 (rank : 50)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	112	Target Neighborhood Hits	116	Shared Neighborhood Hits	28
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

IQEC3_MOUSE
NC score	0.050587 (rank : 51)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	112	Target Neighborhood Hits	274	Shared Neighborhood Hits	22
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

SON_HUMAN
NC score	0.047982 (rank : 52)	θ value	0.0961366 (rank : 34)
Query Neighborhood Hits	112	Target Neighborhood Hits	1568	Shared Neighborhood Hits	46
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

NCOA6_HUMAN
NC score	0.041384 (rank : 53)	θ value	3.0926 (rank : 79)
Query Neighborhood Hits	112	Target Neighborhood Hits	1202	Shared Neighborhood Hits	43
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

LCP2_HUMAN
NC score	0.040580 (rank : 54)	θ value	0.813845 (rank : 51)
Query Neighborhood Hits	112	Target Neighborhood Hits	531	Shared Neighborhood Hits	32
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

RASA2_MOUSE
NC score	0.038201 (rank : 55)	θ value	0.0193708 (rank : 26)
Query Neighborhood Hits	112	Target Neighborhood Hits	159	Shared Neighborhood Hits	15
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

TARA_HUMAN
NC score	0.036630 (rank : 56)	θ value	8.99809 (rank : 110)
Query Neighborhood Hits	112	Target Neighborhood Hits	1626	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

NCOA6_MOUSE
NC score	0.034737 (rank : 57)	θ value	8.99809 (rank : 108)
Query Neighborhood Hits	112	Target Neighborhood Hits	1076	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

NRX2B_HUMAN
NC score	0.033134 (rank : 58)	θ value	2.36792 (rank : 76)
Query Neighborhood Hits	112	Target Neighborhood Hits	481	Shared Neighborhood Hits	25
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

RGS3_MOUSE
NC score	0.032697 (rank : 59)	θ value	0.163984 (rank : 37)
Query Neighborhood Hits	112	Target Neighborhood Hits	1621	Shared Neighborhood Hits	50
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

MLL2_HUMAN
NC score	0.031426 (rank : 60)	θ value	2.36792 (rank : 72)
Query Neighborhood Hits	112	Target Neighborhood Hits	1788	Shared Neighborhood Hits	54
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

MLL3_HUMAN
NC score	0.030496 (rank : 61)	θ value	2.36792 (rank : 73)
Query Neighborhood Hits	112	Target Neighborhood Hits	1644	Shared Neighborhood Hits	43
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

MLL3_MOUSE
NC score	0.029615 (rank : 62)	θ value	2.36792 (rank : 74)
Query Neighborhood Hits	112	Target Neighborhood Hits	1399	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

SON_MOUSE
NC score	0.029076 (rank : 63)	θ value	5.27518 (rank : 92)
Query Neighborhood Hits	112	Target Neighborhood Hits	957	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

MYO10_HUMAN
NC score	0.028077 (rank : 64)	θ value	3.0926 (rank : 78)
Query Neighborhood Hits	112	Target Neighborhood Hits	920	Shared Neighborhood Hits	47
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

EPN1_MOUSE
NC score	0.027460 (rank : 65)	θ value	4.03905 (rank : 84)
Query Neighborhood Hits	112	Target Neighborhood Hits	240	Shared Neighborhood Hits	27
SwissProt Accessions	Q80VP1, O70446	Gene names	Epn1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (Intersectin-EH-binding protein 1) (Ibp1).

COGA1_HUMAN
NC score	0.027073 (rank : 66)	θ value	0.365318 (rank : 41)
Query Neighborhood Hits	112	Target Neighborhood Hits	345	Shared Neighborhood Hits	22
SwissProt Accessions	Q07092	Gene names	COL16A1
Domain Architecture
Description	Collagen alpha-1(XVI) chain precursor.

CDN1C_MOUSE
NC score	0.025577 (rank : 67)	θ value	6.88961 (rank : 97)
Query Neighborhood Hits	112	Target Neighborhood Hits	161	Shared Neighborhood Hits	15
SwissProt Accessions	P49919	Gene names	Cdkn1c, Kip2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57KIP2).

K2C5_MOUSE
NC score	0.023422 (rank : 68)	θ value	0.125558 (rank : 35)
Query Neighborhood Hits	112	Target Neighborhood Hits	505	Shared Neighborhood Hits	19
SwissProt Accessions	Q922U2, Q920F2	Gene names	Krt5, Krt2-5
Domain Architecture	No domain graphic available
Description	Keratin, type II cytoskeletal 5 (Cytokeratin-5) (CK-5) (Keratin-5) (K5).

TIAM1_HUMAN
NC score	0.023262 (rank : 69)	θ value	1.81305 (rank : 70)
Query Neighborhood Hits	112	Target Neighborhood Hits	225	Shared Neighborhood Hits	15
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

NACAM_MOUSE
NC score	0.023178 (rank : 70)	θ value	8.99809 (rank : 107)
Query Neighborhood Hits	112	Target Neighborhood Hits	1866	Shared Neighborhood Hits	44
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

MAGE1_HUMAN
NC score	0.022969 (rank : 71)	θ value	0.47712 (rank : 42)
Query Neighborhood Hits	112	Target Neighborhood Hits	1389	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MYO15_HUMAN
NC score	0.022309 (rank : 72)	θ value	6.88961 (rank : 100)
Query Neighborhood Hits	112	Target Neighborhood Hits	671	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

NRX2A_HUMAN
NC score	0.022288 (rank : 73)	θ value	2.36792 (rank : 75)
Query Neighborhood Hits	112	Target Neighborhood Hits	614	Shared Neighborhood Hits	27
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

UGGG1_MOUSE
NC score	0.021807 (rank : 74)	θ value	5.27518 (rank : 95)
Query Neighborhood Hits	112	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P5E4, Q6NV70	Gene names	Ugcgl1, Gt, Uggt, Ugt1, Ugtr
Domain Architecture	No domain graphic available
Description	UDP-glucose:glycoprotein glucosyltransferase 1 precursor (EC 2.4.1.-) (UDP-glucose ceramide glucosyltransferase-like 1) (UDP-- Glc:glycoprotein glucosyltransferase).

FYCO1_HUMAN
NC score	0.021759 (rank : 75)	θ value	0.62314 (rank : 44)
Query Neighborhood Hits	112	Target Neighborhood Hits	1149	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

MAP1A_HUMAN
NC score	0.021456 (rank : 76)	θ value	1.81305 (rank : 67)
Query Neighborhood Hits	112	Target Neighborhood Hits	1626	Shared Neighborhood Hits	46
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

CSKI1_HUMAN
NC score	0.021044 (rank : 77)	θ value	6.88961 (rank : 98)
Query Neighborhood Hits	112	Target Neighborhood Hits	997	Shared Neighborhood Hits	42
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

K2C6B_MOUSE
NC score	0.020651 (rank : 78)	θ value	1.81305 (rank : 65)
Query Neighborhood Hits	112	Target Neighborhood Hits	506	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Z331	Gene names	Krt6b, K6-beta, Krt2-6b
Domain Architecture	No domain graphic available
Description	Keratin, type II cytoskeletal 6B (Cytokeratin-6B) (CK 6B) (K6b keratin) (Keratin-6 beta) (mK6-beta).

GPTC8_HUMAN
NC score	0.020125 (rank : 79)	θ value	1.81305 (rank : 64)
Query Neighborhood Hits	112	Target Neighborhood Hits	366	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UKJ3, O60300	Gene names	GPATC8, KIAA0553
Domain Architecture	No domain graphic available
Description	G patch domain-containing protein 8.

COA1_HUMAN
NC score	0.020080 (rank : 80)	θ value	1.38821 (rank : 55)
Query Neighborhood Hits	112	Target Neighborhood Hits	49	Shared Neighborhood Hits	5
SwissProt Accessions	Q13085	Gene names	ACACA, ACAC, ACC1, ACCA
Domain Architecture
Description	Acetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)].

K2C5_HUMAN
NC score	0.019655 (rank : 81)	θ value	0.813845 (rank : 50)
Query Neighborhood Hits	112	Target Neighborhood Hits	506	Shared Neighborhood Hits	18
SwissProt Accessions	P13647, Q6PI71, Q6UBJ0, Q8TA91	Gene names	KRT5
Domain Architecture
Description	Keratin, type II cytoskeletal 5 (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (58 kDa cytokeratin).

CSKI1_MOUSE
NC score	0.019466 (rank : 82)	θ value	0.813845 (rank : 49)
Query Neighborhood Hits	112	Target Neighborhood Hits	1031	Shared Neighborhood Hits	35
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

FA47B_HUMAN
NC score	0.018547 (rank : 83)	θ value	6.88961 (rank : 99)
Query Neighborhood Hits	112	Target Neighborhood Hits	431	Shared Neighborhood Hits	24
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

NSD1_MOUSE
NC score	0.018331 (rank : 84)	θ value	3.0926 (rank : 80)
Query Neighborhood Hits	112	Target Neighborhood Hits	472	Shared Neighborhood Hits	23
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

SEM6C_MOUSE
NC score	0.018062 (rank : 85)	θ value	0.163984 (rank : 38)
Query Neighborhood Hits	112	Target Neighborhood Hits	352	Shared Neighborhood Hits	22
SwissProt Accessions	Q9WTM3	Gene names	Sema6c, Semay
Domain Architecture
Description	Semaphorin-6C precursor (Semaphorin Y) (Sema Y).

FOXN1_MOUSE
NC score	0.017333 (rank : 86)	θ value	1.81305 (rank : 63)
Query Neighborhood Hits	112	Target Neighborhood Hits	300	Shared Neighborhood Hits	16
SwissProt Accessions	Q61575	Gene names	Foxn1, Fkh19, Hfh11, Whn
Domain Architecture
Description	Forkhead box protein N1 (Transcription factor winged-helix nude) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HNF-3/forkhead homolog 11) (HFH-11).

EGR4_HUMAN
NC score	0.016848 (rank : 87)	θ value	0.00298849 (rank : 19)
Query Neighborhood Hits	112	Target Neighborhood Hits	939	Shared Neighborhood Hits	15
SwissProt Accessions	Q05215	Gene names	EGR4
Domain Architecture
Description	Early growth response protein 4 (EGR-4) (AT133).

K2C6A_HUMAN
NC score	0.016616 (rank : 88)	θ value	4.03905 (rank : 85)
Query Neighborhood Hits	112	Target Neighborhood Hits	505	Shared Neighborhood Hits	20
SwissProt Accessions	P02538, Q6NT67, Q96CL4	Gene names	KRT6A, K6A
Domain Architecture
Description	Keratin, type II cytoskeletal 6A (Cytokeratin-6A) (CK 6A) (K6a keratin).

K2C6C_HUMAN
NC score	0.016605 (rank : 89)	θ value	4.03905 (rank : 86)
Query Neighborhood Hits	112	Target Neighborhood Hits	503	Shared Neighborhood Hits	20
SwissProt Accessions	P48666	Gene names	KRT6C
Domain Architecture
Description	Keratin, type II cytoskeletal 6C (Cytokeratin-6C) (CK 6C) (K6c keratin).

FOXJ2_HUMAN
NC score	0.016545 (rank : 90)	θ value	0.62314 (rank : 43)
Query Neighborhood Hits	112	Target Neighborhood Hits	239	Shared Neighborhood Hits	15
SwissProt Accessions	Q9P0K8, Q96PS9, Q9NSN5	Gene names	FOXJ2, FHX
Domain Architecture
Description	Forkhead box protein J2 (Fork head homologous X).

TIAM1_MOUSE
NC score	0.016512 (rank : 91)	θ value	8.99809 (rank : 112)
Query Neighborhood Hits	112	Target Neighborhood Hits	205	Shared Neighborhood Hits	16
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

K2C8_HUMAN
NC score	0.015134 (rank : 92)	θ value	5.27518 (rank : 89)
Query Neighborhood Hits	112	Target Neighborhood Hits	593	Shared Neighborhood Hits	22
SwissProt Accessions	P05787, Q14099, Q14716, Q14717, Q53GJ0, Q6DHW5, Q6GMY0, Q96J60	Gene names	KRT8, CYK8
Domain Architecture
Description	Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8).

K2C6A_MOUSE
NC score	0.015044 (rank : 93)	θ value	8.99809 (rank : 105)
Query Neighborhood Hits	112	Target Neighborhood Hits	481	Shared Neighborhood Hits	15
SwissProt Accessions	P50446, Q9Z332	Gene names	Krt6a, Ker2, Krt2-6, Krt2-6a, Krt6
Domain Architecture
Description	Keratin, type II cytoskeletal 6A (Cytokeratin-6A) (CK 6A) (K6a keratin) (Keratin-6 alpha) (mK6-alpha).

PYR1_HUMAN
NC score	0.014987 (rank : 94)	θ value	1.81305 (rank : 69)
Query Neighborhood Hits	112	Target Neighborhood Hits	119	Shared Neighborhood Hits	8
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].

RPGF1_HUMAN
NC score	0.014918 (rank : 95)	θ value	1.06291 (rank : 54)
Query Neighborhood Hits	112	Target Neighborhood Hits	262	Shared Neighborhood Hits	8
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

CO5A2_HUMAN
NC score	0.014873 (rank : 96)	θ value	1.81305 (rank : 62)
Query Neighborhood Hits	112	Target Neighborhood Hits	760	Shared Neighborhood Hits	29
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

K2C8_MOUSE
NC score	0.014767 (rank : 97)	θ value	1.81305 (rank : 66)
Query Neighborhood Hits	112	Target Neighborhood Hits	576	Shared Neighborhood Hits	21
SwissProt Accessions	P11679, Q3KQK5, Q3TGI1, Q3TJE1, Q3TKY7, Q61463, Q61518, Q61519	Gene names	Krt8, Krt2-8
Domain Architecture
Description	Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Cytokeratin endo A).

ANK2_HUMAN
NC score	0.013953 (rank : 98)	θ value	5.27518 (rank : 88)
Query Neighborhood Hits	112	Target Neighborhood Hits	1615	Shared Neighborhood Hits	42
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

MYO15_MOUSE
NC score	0.013450 (rank : 99)	θ value	0.813845 (rank : 52)
Query Neighborhood Hits	112	Target Neighborhood Hits	467	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

TRPS1_HUMAN
NC score	0.012416 (rank : 100)	θ value	5.27518 (rank : 94)
Query Neighborhood Hits	112	Target Neighborhood Hits	539	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UHF7, Q9NWE1, Q9UHH6	Gene names	TRPS1
Domain Architecture
Description	Zinc finger transcription factor Trps1 (Zinc finger protein GC79) (Tricho-rhino-phalangeal syndrome type I protein).

GAK_MOUSE
NC score	0.012195 (rank : 101)	θ value	0.0563607 (rank : 31)
Query Neighborhood Hits	112	Target Neighborhood Hits	964	Shared Neighborhood Hits	15
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

ROCK1_HUMAN
NC score	0.011683 (rank : 102)	θ value	1.38821 (rank : 59)
Query Neighborhood Hits	112	Target Neighborhood Hits	2000	Shared Neighborhood Hits	34
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ROCK1_MOUSE
NC score	0.011274 (rank : 103)	θ value	1.38821 (rank : 60)
Query Neighborhood Hits	112	Target Neighborhood Hits	2126	Shared Neighborhood Hits	36
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

TRPS1_MOUSE
NC score	0.011109 (rank : 104)	θ value	6.88961 (rank : 102)
Query Neighborhood Hits	112	Target Neighborhood Hits	609	Shared Neighborhood Hits	7
SwissProt Accessions	Q925H1	Gene names	Trps1
Domain Architecture
Description	Zinc finger transcription factor Trps1.

ASPP2_HUMAN
NC score	0.010597 (rank : 105)	θ value	4.03905 (rank : 83)
Query Neighborhood Hits	112	Target Neighborhood Hits	1156	Shared Neighborhood Hits	40
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

NFIC_MOUSE
NC score	0.009841 (rank : 106)	θ value	5.27518 (rank : 90)
Query Neighborhood Hits	112	Target Neighborhood Hits	66	Shared Neighborhood Hits	5
SwissProt Accessions	P70255, O09072, P70256, Q3U2I9, Q99MA3, Q99MA4, Q99MA5, Q99MA6, Q99MA7, Q99MA8, Q9R1G3	Gene names	Nfic
Domain Architecture
Description	Nuclear factor 1 C-type (Nuclear factor 1/C) (NF1-C) (NFI-C) (NF-I/C) (CCAAT-box-binding transcription factor) (CTF) (TGGCA-binding protein).

GIMA4_HUMAN
NC score	0.009144 (rank : 107)	θ value	8.99809 (rank : 104)
Query Neighborhood Hits	112	Target Neighborhood Hits	217	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NUV9	Gene names	GIMAP4, IAN1, IMAP4
Domain Architecture
Description	GTPase, IMAP family member 4 (Immunity-associated protein 4) (Immunity-associated nucleotide 1 protein) (hIAN1).

REXO1_MOUSE
NC score	0.008972 (rank : 108)	θ value	6.88961 (rank : 101)
Query Neighborhood Hits	112	Target Neighborhood Hits	166	Shared Neighborhood Hits	10
SwissProt Accessions	Q7TT28, Q3UMP1, Q69ZR0, Q6NSQ6, Q6PI95, Q9DA29	Gene names	Rexo1, Kiaa1138, Tceb3bp1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Transcription elongation factor B polypeptide 3-binding protein 1).

PICAL_HUMAN
NC score	0.008516 (rank : 109)	θ value	8.99809 (rank : 109)
Query Neighborhood Hits	112	Target Neighborhood Hits	57	Shared Neighborhood Hits	4
SwissProt Accessions	Q13492, O60700, Q86XZ9	Gene names	PICALM, CALM
Domain Architecture
Description	Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein).

ZN516_MOUSE
NC score	0.007647 (rank : 110)	θ value	1.38821 (rank : 61)
Query Neighborhood Hits	112	Target Neighborhood Hits	1197	Shared Neighborhood Hits	34
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

PER2_MOUSE
NC score	0.006746 (rank : 111)	θ value	5.27518 (rank : 91)
Query Neighborhood Hits	112	Target Neighborhood Hits	325	Shared Neighborhood Hits	6
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

LAMA3_HUMAN
NC score	0.006430 (rank : 112)	θ value	8.99809 (rank : 106)
Query Neighborhood Hits	112	Target Neighborhood Hits	760	Shared Neighborhood Hits	17
SwissProt Accessions	Q16787, Q13679, Q13680, Q96TG0	Gene names	LAMA3
Domain Architecture
Description	Laminin alpha-3 chain precursor (Epiligrin 170 kDa subunit) (E170) (Nicein subunit alpha).

PEX1_HUMAN
NC score	0.006373 (rank : 113)	θ value	2.36792 (rank : 77)
Query Neighborhood Hits	112	Target Neighborhood Hits	98	Shared Neighborhood Hits	4
SwissProt Accessions	O43933, Q96S71, Q96S72, Q96S73, Q99994	Gene names	PEX1
Domain Architecture
Description	Peroxisome biogenesis factor 1 (Peroxin-1) (Peroxisome biogenesis disorder protein 1).

ULK1_MOUSE
NC score	0.005273 (rank : 114)	θ value	3.0926 (rank : 82)
Query Neighborhood Hits	112	Target Neighborhood Hits	1214	Shared Neighborhood Hits	29
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

TITIN_HUMAN
NC score	0.004981 (rank : 115)	θ value	5.27518 (rank : 93)
Query Neighborhood Hits	112	Target Neighborhood Hits	2923	Shared Neighborhood Hits	47
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

TBX6_MOUSE
NC score	0.002304 (rank : 116)	θ value	8.99809 (rank : 111)
Query Neighborhood Hits	112	Target Neighborhood Hits	54	Shared Neighborhood Hits	2
SwissProt Accessions	P70327	Gene names	Tbx6
Domain Architecture
Description	T-box transcription factor TBX6 (T-box protein 6).

ULK1_HUMAN
NC score	0.001982 (rank : 117)	θ value	6.88961 (rank : 103)
Query Neighborhood Hits	112	Target Neighborhood Hits	1121	Shared Neighborhood Hits	23
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

CD2L2_HUMAN
NC score	-0.000220 (rank : 118)	θ value	6.88961 (rank : 96)
Query Neighborhood Hits	112	Target Neighborhood Hits	1439	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

UFO_HUMAN
NC score	-0.001027 (rank : 119)	θ value	4.03905 (rank : 87)
Query Neighborhood Hits	112	Target Neighborhood Hits	981	Shared Neighborhood Hits	10
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).