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Network neighborhood for query Sequence : PICAL_HUMAN

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PICAL_HUMAN
SwissProt Accessions	Q13492, O60700, Q86XZ9	Gene names	PICALM, CALM
Domain Architecture
Description	Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PICAL_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	57	Target Neighborhood Hits	57	Shared Neighborhood Hits	57
SwissProt Accessions	Q13492, O60700, Q86XZ9	Gene names	PICALM, CALM
Domain Architecture
Description	Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein).

PICA_MOUSE
θ value	0 (rank : 2)	NC score	0.994596 (rank : 2)
Query Neighborhood Hits	57	Target Neighborhood Hits	63	Shared Neighborhood Hits	44
SwissProt Accessions	Q7M6Y3, Q3TS04, Q811P1, Q8BUF6, Q8CIH8, Q8R0A9, Q8R3E1, Q8VDN5, Q921L0	Gene names	Picalm, Calm, Fit1
Domain Architecture
Description	Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia) (CALM).

AP180_MOUSE
θ value	3.62588e-142 (rank : 3)	NC score	0.879565 (rank : 4)
Query Neighborhood Hits	57	Target Neighborhood Hits	194	Shared Neighborhood Hits	14
SwissProt Accessions	Q61548, Q61547	Gene names	Snap91
Domain Architecture
Description	Clathrin coat assembly protein AP180 (Clathrin coat-associated protein AP180) (91 kDa synaptosomal-associated protein) (Phosphoprotein F1- 20).

AP180_HUMAN
θ value	1.52337e-140 (rank : 4)	NC score	0.884120 (rank : 3)
Query Neighborhood Hits	57	Target Neighborhood Hits	183	Shared Neighborhood Hits	9
SwissProt Accessions	O60641, Q5JX13, Q68DL9, Q6P9D3, Q9NTY7	Gene names	SNAP91, KIAA0656
Domain Architecture
Description	Clathrin coat assembly protein AP180 (Clathrin coat-associated protein AP180) (91 kDa synaptosomal-associated protein).

CDX1_HUMAN
θ value	0.0431538 (rank : 5)	NC score	0.023460 (rank : 33)
Query Neighborhood Hits	57	Target Neighborhood Hits	382	Shared Neighborhood Hits	4
SwissProt Accessions	P47902, Q4VAU4, Q9NYK8	Gene names	CDX1
Domain Architecture
Description	Homeobox protein CDX-1 (Caudal-type homeobox protein 1).

MACF1_MOUSE
θ value	0.0563607 (rank : 6)	NC score	0.053243 (rank : 14)
Query Neighborhood Hits	57	Target Neighborhood Hits	1313	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

RB6I2_HUMAN
θ value	0.0563607 (rank : 7)	NC score	0.038167 (rank : 19)
Query Neighborhood Hits	57	Target Neighborhood Hits	1584	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

ATRX_HUMAN
θ value	0.0736092 (rank : 8)	NC score	0.036380 (rank : 22)
Query Neighborhood Hits	57	Target Neighborhood Hits	842	Shared Neighborhood Hits	14
SwissProt Accessions	P46100, P51068, Q15886, Q59FB5, Q59H31, Q5H9A2, Q5JWI4, Q7Z2J1, Q9H0Z1, Q9NTS3	Gene names	ATRX, RAD54L, XH2
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf- HX).

RB6I2_MOUSE
θ value	0.125558 (rank : 9)	NC score	0.037980 (rank : 20)
Query Neighborhood Hits	57	Target Neighborhood Hits	1433	Shared Neighborhood Hits	27
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

LEG4_MOUSE
θ value	0.279714 (rank : 10)	NC score	0.039331 (rank : 18)
Query Neighborhood Hits	57	Target Neighborhood Hits	32	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K419, O88353, Q91X74	Gene names	Lgals4
Domain Architecture
Description	Galectin-4 (Lactose-binding lectin 4).

NUMA1_HUMAN
θ value	0.279714 (rank : 11)	NC score	0.034807 (rank : 23)
Query Neighborhood Hits	57	Target Neighborhood Hits	1523	Shared Neighborhood Hits	23
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

DAZP1_MOUSE
θ value	0.365318 (rank : 12)	NC score	0.028303 (rank : 27)
Query Neighborhood Hits	57	Target Neighborhood Hits	313	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JII5	Gene names	Dazap1
Domain Architecture
Description	DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1).

MACF1_HUMAN
θ value	0.365318 (rank : 13)	NC score	0.048209 (rank : 15)
Query Neighborhood Hits	57	Target Neighborhood Hits	1341	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

MACF4_HUMAN
θ value	0.365318 (rank : 14)	NC score	0.054407 (rank : 13)
Query Neighborhood Hits	57	Target Neighborhood Hits	1321	Shared Neighborhood Hits	25
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

SYNE2_HUMAN
θ value	0.365318 (rank : 15)	NC score	0.039806 (rank : 17)
Query Neighborhood Hits	57	Target Neighborhood Hits	1323	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

EPN4_HUMAN
θ value	0.47712 (rank : 16)	NC score	0.090463 (rank : 5)
Query Neighborhood Hits	57	Target Neighborhood Hits	50	Shared Neighborhood Hits	6
SwissProt Accessions	Q14677, Q8NAF1, Q96E05	Gene names	CLINT1, ENTH, EPN4, EPNR, KIAA0171
Domain Architecture
Description	Clathrin interactor 1 (Epsin-4) (Epsin-related protein) (EpsinR) (Enthoprotin) (Clathrin-interacting protein localized in the trans- Golgi region) (Clint).

EPN4_MOUSE
θ value	0.47712 (rank : 17)	NC score	0.090263 (rank : 6)
Query Neighborhood Hits	57	Target Neighborhood Hits	58	Shared Neighborhood Hits	6
SwissProt Accessions	Q99KN9, Q8CFH4	Gene names	Clint1, Enth, Epn4, Epnr, Kiaa0171
Domain Architecture
Description	Clathrin interactor 1 (Epsin-4) (Epsin-related protein) (EpsinR) (Enthoprotin).

KIF22_HUMAN
θ value	0.813845 (rank : 18)	NC score	0.019848 (rank : 42)
Query Neighborhood Hits	57	Target Neighborhood Hits	110	Shared Neighborhood Hits	7
SwissProt Accessions	Q14807, O94814, Q9BT46	Gene names	KIF22, KID, KNSL4
Domain Architecture
Description	Kinesin-like protein KIF22 (Kinesin-like DNA-binding protein) (Kinesin-like protein 4).

NUPL_HUMAN
θ value	0.813845 (rank : 19)	NC score	0.025774 (rank : 31)
Query Neighborhood Hits	57	Target Neighborhood Hits	68	Shared Neighborhood Hits	2
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).

SFPQ_HUMAN
θ value	0.813845 (rank : 20)	NC score	0.028606 (rank : 25)
Query Neighborhood Hits	57	Target Neighborhood Hits	986	Shared Neighborhood Hits	18
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

YLPM1_MOUSE
θ value	0.813845 (rank : 21)	NC score	0.043534 (rank : 16)
Query Neighborhood Hits	57	Target Neighborhood Hits	505	Shared Neighborhood Hits	7
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

DC1L2_MOUSE
θ value	1.06291 (rank : 22)	NC score	0.036821 (rank : 21)
Query Neighborhood Hits	57	Target Neighborhood Hits	173	Shared Neighborhood Hits	5
SwissProt Accessions	Q6PDL0	Gene names	Dync1li2, Dncli2, Dnclic2
Domain Architecture	No domain graphic available
Description	Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic).

DAZP1_HUMAN
θ value	1.38821 (rank : 23)	NC score	0.026757 (rank : 30)
Query Neighborhood Hits	57	Target Neighborhood Hits	313	Shared Neighborhood Hits	7
SwissProt Accessions	Q96EP5, Q96MJ3, Q9NRR9	Gene names	DAZAP1
Domain Architecture
Description	DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1).

ITSN2_MOUSE
θ value	1.38821 (rank : 24)	NC score	0.019984 (rank : 41)
Query Neighborhood Hits	57	Target Neighborhood Hits	1371	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

FOXQ1_HUMAN
θ value	1.81305 (rank : 25)	NC score	0.010468 (rank : 56)
Query Neighborhood Hits	57	Target Neighborhood Hits	115	Shared Neighborhood Hits	3
SwissProt Accessions	Q9C009, Q9NS06	Gene names	FOXQ1, HFH1
Domain Architecture
Description	Forkhead box protein Q1 (Hepatocyte nuclear factor 3 forkhead homolog 1) (HNF-3/forkhead-like protein 1) (HFH-1).

GOGB1_HUMAN
θ value	1.81305 (rank : 26)	NC score	0.027856 (rank : 28)
Query Neighborhood Hits	57	Target Neighborhood Hits	2297	Shared Neighborhood Hits	26
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

MK07_MOUSE
θ value	1.81305 (rank : 27)	NC score	0.001658 (rank : 61)
Query Neighborhood Hits	57	Target Neighborhood Hits	1054	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

H14_MOUSE
θ value	3.0926 (rank : 28)	NC score	0.024661 (rank : 32)
Query Neighborhood Hits	57	Target Neighborhood Hits	88	Shared Neighborhood Hits	3
SwissProt Accessions	P43274	Gene names	Hist1h1e, H1f4
Domain Architecture
Description	Histone H1.4 (H1 VAR.2) (H1e).

MLL2_HUMAN
θ value	3.0926 (rank : 29)	NC score	0.016968 (rank : 45)
Query Neighborhood Hits	57	Target Neighborhood Hits	1788	Shared Neighborhood Hits	27
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

AKAP3_HUMAN
θ value	4.03905 (rank : 30)	NC score	0.016078 (rank : 49)
Query Neighborhood Hits	57	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	O75969, O75945, Q9UM61	Gene names	AKAP3, AKAP110, SOB1
Domain Architecture
Description	A-kinase anchor protein 3 (Protein kinase A-anchoring protein 3) (PRKA3) (A-kinase anchor protein 110 kDa) (AKAP 110) (Sperm oocyte- binding protein) (Fibrousheathin-1) (Fibrousheathin I) (Fibrous sheath protein of 95 kDa) (FSP95).

E41L2_MOUSE
θ value	4.03905 (rank : 31)	NC score	0.012919 (rank : 53)
Query Neighborhood Hits	57	Target Neighborhood Hits	459	Shared Neighborhood Hits	13
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

SMCA4_HUMAN
θ value	4.03905 (rank : 32)	NC score	0.011187 (rank : 55)
Query Neighborhood Hits	57	Target Neighborhood Hits	597	Shared Neighborhood Hits	8
SwissProt Accessions	P51532, O95052, Q9HBD3	Gene names	SMARCA4, BRG1, SNF2B, SNF2L4
Domain Architecture
Description	Probable global transcription activator SNF2L4 (EC 3.6.1.-) (ATP- dependent helicase SMARCA4) (SNF2-beta) (BRG-1 protein) (Mitotic growth and transcription activator) (Brahma protein homolog 1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4).

T2EA_HUMAN
θ value	4.03905 (rank : 33)	NC score	0.032380 (rank : 24)
Query Neighborhood Hits	57	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	P29083, Q16103	Gene names	GTF2E1, TF2E1
Domain Architecture
Description	Transcription initiation factor IIE subunit alpha (TFIIE-alpha) (General transcription factor IIE 56 kDa subunit).

ARS2_HUMAN
θ value	5.27518 (rank : 34)	NC score	0.022252 (rank : 35)
Query Neighborhood Hits	57	Target Neighborhood Hits	186	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BXP5, O95808, Q9BWP6, Q9BXP4	Gene names	ARS2, ASR2
Domain Architecture
Description	Arsenite-resistance protein 2.

ARS2_MOUSE
θ value	5.27518 (rank : 35)	NC score	0.022052 (rank : 36)
Query Neighborhood Hits	57	Target Neighborhood Hits	212	Shared Neighborhood Hits	4
SwissProt Accessions	Q99MR6, Q99MR4, Q99MR5, Q99MR7	Gene names	Ars2, Asr2
Domain Architecture
Description	Arsenite-resistance protein 2.

ATX2_HUMAN
θ value	5.27518 (rank : 36)	NC score	0.018488 (rank : 43)
Query Neighborhood Hits	57	Target Neighborhood Hits	375	Shared Neighborhood Hits	6
SwissProt Accessions	Q99700, Q6ZQZ7, Q99493	Gene names	ATXN2, ATX2, SCA2, TNRC13
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein).

CASL_MOUSE
θ value	5.27518 (rank : 37)	NC score	0.018243 (rank : 44)
Query Neighborhood Hits	57	Target Neighborhood Hits	225	Shared Neighborhood Hits	7
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CENPJ_HUMAN
θ value	5.27518 (rank : 38)	NC score	0.028316 (rank : 26)
Query Neighborhood Hits	57	Target Neighborhood Hits	721	Shared Neighborhood Hits	19
SwissProt Accessions	Q9HC77, Q5T6R5, Q96KS5, Q9C067	Gene names	CENPJ, CPAP, LAP, LIP1
Domain Architecture	No domain graphic available
Description	Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1).

NCOA2_HUMAN
θ value	5.27518 (rank : 39)	NC score	0.016552 (rank : 48)
Query Neighborhood Hits	57	Target Neighborhood Hits	281	Shared Neighborhood Hits	5
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

SPTA1_MOUSE
θ value	5.27518 (rank : 40)	NC score	0.027214 (rank : 29)
Query Neighborhood Hits	57	Target Neighborhood Hits	675	Shared Neighborhood Hits	15
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

AMPH_HUMAN
θ value	6.88961 (rank : 41)	NC score	0.016860 (rank : 46)
Query Neighborhood Hits	57	Target Neighborhood Hits	455	Shared Neighborhood Hits	8
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

CN032_MOUSE
θ value	6.88961 (rank : 42)	NC score	0.021183 (rank : 38)
Query Neighborhood Hits	57	Target Neighborhood Hits	233	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BH93, Q3TF12, Q3TGL0, Q8CC90	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf32 homolog.

GOGA4_MOUSE
θ value	6.88961 (rank : 43)	NC score	0.022468 (rank : 34)
Query Neighborhood Hits	57	Target Neighborhood Hits	1939	Shared Neighborhood Hits	25
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

MYPT1_MOUSE
θ value	6.88961 (rank : 44)	NC score	0.006456 (rank : 59)
Query Neighborhood Hits	57	Target Neighborhood Hits	539	Shared Neighborhood Hits	8
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

TLN1_HUMAN
θ value	6.88961 (rank : 45)	NC score	0.013937 (rank : 51)
Query Neighborhood Hits	57	Target Neighborhood Hits	218	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

TLN1_MOUSE
θ value	6.88961 (rank : 46)	NC score	0.013664 (rank : 52)
Query Neighborhood Hits	57	Target Neighborhood Hits	213	Shared Neighborhood Hits	7
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

AINX_MOUSE
θ value	8.99809 (rank : 47)	NC score	0.007316 (rank : 58)
Query Neighborhood Hits	57	Target Neighborhood Hits	448	Shared Neighborhood Hits	13
SwissProt Accessions	P46660, Q61958, Q8VCW5	Gene names	Ina
Domain Architecture
Description	Alpha-internexin (Alpha-Inx) (66 kDa neurofilament protein) (Neurofilament-66) (NF-66).

CE110_HUMAN
θ value	8.99809 (rank : 48)	NC score	0.020181 (rank : 40)
Query Neighborhood Hits	57	Target Neighborhood Hits	197	Shared Neighborhood Hits	10
SwissProt Accessions	O43303, O43335, Q68DV9, Q8NE13	Gene names	CEP110, CP110, KIAA0419
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 110 kDa (Cep110 protein).

DYN2_HUMAN
θ value	8.99809 (rank : 49)	NC score	0.008516 (rank : 57)
Query Neighborhood Hits	57	Target Neighborhood Hits	112	Shared Neighborhood Hits	4
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

DYN3_HUMAN
θ value	8.99809 (rank : 50)	NC score	0.011376 (rank : 54)
Query Neighborhood Hits	57	Target Neighborhood Hits	158	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

EF1D_MOUSE
θ value	8.99809 (rank : 51)	NC score	0.020921 (rank : 39)
Query Neighborhood Hits	57	Target Neighborhood Hits	50	Shared Neighborhood Hits	8
SwissProt Accessions	P57776, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5	Gene names	Eef1d
Domain Architecture
Description	Elongation factor 1-delta (EF-1-delta).

FOXB1_MOUSE
θ value	8.99809 (rank : 52)	NC score	0.005255 (rank : 60)
Query Neighborhood Hits	57	Target Neighborhood Hits	125	Shared Neighborhood Hits	3
SwissProt Accessions	Q64732, O08753	Gene names	Foxb1, Fkh5, Foxb1a, Foxb1b, Mf3
Domain Architecture
Description	Forkhead box protein B1 (Transcription factor FKH-5).

KAD7_MOUSE
θ value	8.99809 (rank : 53)	NC score	0.016604 (rank : 47)
Query Neighborhood Hits	57	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D2H2, Q8BVH3	Gene names	Ak7
Domain Architecture
Description	Putative adenylate kinase 7 (EC 2.7.4.3).

LIPA2_MOUSE
θ value	8.99809 (rank : 54)	NC score	0.015902 (rank : 50)
Query Neighborhood Hits	57	Target Neighborhood Hits	1282	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BSS9, Q8BN73	Gene names	Ppfia2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

PCNT_MOUSE
θ value	8.99809 (rank : 55)	NC score	0.021969 (rank : 37)
Query Neighborhood Hits	57	Target Neighborhood Hits	1207	Shared Neighborhood Hits	20
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

RU1C_HUMAN
θ value	8.99809 (rank : 56)	NC score	0.060791 (rank : 8)
Query Neighborhood Hits	57	Target Neighborhood Hits	81	Shared Neighborhood Hits	7
SwissProt Accessions	P09234	Gene names	SNRPC
Domain Architecture
Description	U1 small nuclear ribonucleoprotein C (U1 snRNP protein C) (U1C protein) (U1-C).

RU1C_MOUSE
θ value	8.99809 (rank : 57)	NC score	0.066924 (rank : 7)
Query Neighborhood Hits	57	Target Neighborhood Hits	83	Shared Neighborhood Hits	7
SwissProt Accessions	Q62241	Gene names	Snrp1c, Snrpc
Domain Architecture
Description	U1 small nuclear ribonucleoprotein C (U1 snRNP protein C) (U1C protein) (U1-C).

DOT1L_HUMAN
θ value	θ > 10 (rank : 58)	NC score	0.055882 (rank : 11)
Query Neighborhood Hits	57	Target Neighborhood Hits	660	Shared Neighborhood Hits	13
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

EPN3_MOUSE
θ value	θ > 10 (rank : 59)	NC score	0.054903 (rank : 12)
Query Neighborhood Hits	57	Target Neighborhood Hits	312	Shared Neighborhood Hits	11
SwissProt Accessions	Q91W69, Q9CV55	Gene names	Epn3
Domain Architecture
Description	Epsin-3 (EPS-15-interacting protein 3).

LEUK_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.058469 (rank : 10)
Query Neighborhood Hits	57	Target Neighborhood Hits	213	Shared Neighborhood Hits	3
SwissProt Accessions	P16150	Gene names	SPN, CD43
Domain Architecture	No domain graphic available
Description	Leukosialin precursor (Leukocyte sialoglycoprotein) (Sialophorin) (Galactoglycoprotein) (GALGP) (CD43 antigen).

MUC1_HUMAN
θ value	θ > 10 (rank : 61)	NC score	0.059741 (rank : 9)
Query Neighborhood Hits	57	Target Neighborhood Hits	975	Shared Neighborhood Hits	18
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

Hits sorted by NC score

PICAL_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	57	Target Neighborhood Hits	57	Shared Neighborhood Hits	57
SwissProt Accessions	Q13492, O60700, Q86XZ9	Gene names	PICALM, CALM
Domain Architecture
Description	Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein).

PICA_MOUSE
NC score	0.994596 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	57	Target Neighborhood Hits	63	Shared Neighborhood Hits	44
SwissProt Accessions	Q7M6Y3, Q3TS04, Q811P1, Q8BUF6, Q8CIH8, Q8R0A9, Q8R3E1, Q8VDN5, Q921L0	Gene names	Picalm, Calm, Fit1
Domain Architecture
Description	Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia) (CALM).

AP180_HUMAN
NC score	0.884120 (rank : 3)	θ value	1.52337e-140 (rank : 4)
Query Neighborhood Hits	57	Target Neighborhood Hits	183	Shared Neighborhood Hits	9
SwissProt Accessions	O60641, Q5JX13, Q68DL9, Q6P9D3, Q9NTY7	Gene names	SNAP91, KIAA0656
Domain Architecture
Description	Clathrin coat assembly protein AP180 (Clathrin coat-associated protein AP180) (91 kDa synaptosomal-associated protein).

AP180_MOUSE
NC score	0.879565 (rank : 4)	θ value	3.62588e-142 (rank : 3)
Query Neighborhood Hits	57	Target Neighborhood Hits	194	Shared Neighborhood Hits	14
SwissProt Accessions	Q61548, Q61547	Gene names	Snap91
Domain Architecture
Description	Clathrin coat assembly protein AP180 (Clathrin coat-associated protein AP180) (91 kDa synaptosomal-associated protein) (Phosphoprotein F1- 20).

EPN4_HUMAN
NC score	0.090463 (rank : 5)	θ value	0.47712 (rank : 16)
Query Neighborhood Hits	57	Target Neighborhood Hits	50	Shared Neighborhood Hits	6
SwissProt Accessions	Q14677, Q8NAF1, Q96E05	Gene names	CLINT1, ENTH, EPN4, EPNR, KIAA0171
Domain Architecture
Description	Clathrin interactor 1 (Epsin-4) (Epsin-related protein) (EpsinR) (Enthoprotin) (Clathrin-interacting protein localized in the trans- Golgi region) (Clint).

EPN4_MOUSE
NC score	0.090263 (rank : 6)	θ value	0.47712 (rank : 17)
Query Neighborhood Hits	57	Target Neighborhood Hits	58	Shared Neighborhood Hits	6
SwissProt Accessions	Q99KN9, Q8CFH4	Gene names	Clint1, Enth, Epn4, Epnr, Kiaa0171
Domain Architecture
Description	Clathrin interactor 1 (Epsin-4) (Epsin-related protein) (EpsinR) (Enthoprotin).

RU1C_MOUSE
NC score	0.066924 (rank : 7)	θ value	8.99809 (rank : 57)
Query Neighborhood Hits	57	Target Neighborhood Hits	83	Shared Neighborhood Hits	7
SwissProt Accessions	Q62241	Gene names	Snrp1c, Snrpc
Domain Architecture
Description	U1 small nuclear ribonucleoprotein C (U1 snRNP protein C) (U1C protein) (U1-C).

RU1C_HUMAN
NC score	0.060791 (rank : 8)	θ value	8.99809 (rank : 56)
Query Neighborhood Hits	57	Target Neighborhood Hits	81	Shared Neighborhood Hits	7
SwissProt Accessions	P09234	Gene names	SNRPC
Domain Architecture
Description	U1 small nuclear ribonucleoprotein C (U1 snRNP protein C) (U1C protein) (U1-C).

MUC1_HUMAN
NC score	0.059741 (rank : 9)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	57	Target Neighborhood Hits	975	Shared Neighborhood Hits	18
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

LEUK_HUMAN
NC score	0.058469 (rank : 10)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	57	Target Neighborhood Hits	213	Shared Neighborhood Hits	3
SwissProt Accessions	P16150	Gene names	SPN, CD43
Domain Architecture	No domain graphic available
Description	Leukosialin precursor (Leukocyte sialoglycoprotein) (Sialophorin) (Galactoglycoprotein) (GALGP) (CD43 antigen).

DOT1L_HUMAN
NC score	0.055882 (rank : 11)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	57	Target Neighborhood Hits	660	Shared Neighborhood Hits	13
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

EPN3_MOUSE
NC score	0.054903 (rank : 12)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	57	Target Neighborhood Hits	312	Shared Neighborhood Hits	11
SwissProt Accessions	Q91W69, Q9CV55	Gene names	Epn3
Domain Architecture
Description	Epsin-3 (EPS-15-interacting protein 3).

MACF4_HUMAN
NC score	0.054407 (rank : 13)	θ value	0.365318 (rank : 14)
Query Neighborhood Hits	57	Target Neighborhood Hits	1321	Shared Neighborhood Hits	25
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

MACF1_MOUSE
NC score	0.053243 (rank : 14)	θ value	0.0563607 (rank : 6)
Query Neighborhood Hits	57	Target Neighborhood Hits	1313	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

MACF1_HUMAN
NC score	0.048209 (rank : 15)	θ value	0.365318 (rank : 13)
Query Neighborhood Hits	57	Target Neighborhood Hits	1341	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

YLPM1_MOUSE
NC score	0.043534 (rank : 16)	θ value	0.813845 (rank : 21)
Query Neighborhood Hits	57	Target Neighborhood Hits	505	Shared Neighborhood Hits	7
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

SYNE2_HUMAN
NC score	0.039806 (rank : 17)	θ value	0.365318 (rank : 15)
Query Neighborhood Hits	57	Target Neighborhood Hits	1323	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

LEG4_MOUSE
NC score	0.039331 (rank : 18)	θ value	0.279714 (rank : 10)
Query Neighborhood Hits	57	Target Neighborhood Hits	32	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K419, O88353, Q91X74	Gene names	Lgals4
Domain Architecture
Description	Galectin-4 (Lactose-binding lectin 4).

RB6I2_HUMAN
NC score	0.038167 (rank : 19)	θ value	0.0563607 (rank : 7)
Query Neighborhood Hits	57	Target Neighborhood Hits	1584	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

RB6I2_MOUSE
NC score	0.037980 (rank : 20)	θ value	0.125558 (rank : 9)
Query Neighborhood Hits	57	Target Neighborhood Hits	1433	Shared Neighborhood Hits	27
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

DC1L2_MOUSE
NC score	0.036821 (rank : 21)	θ value	1.06291 (rank : 22)
Query Neighborhood Hits	57	Target Neighborhood Hits	173	Shared Neighborhood Hits	5
SwissProt Accessions	Q6PDL0	Gene names	Dync1li2, Dncli2, Dnclic2
Domain Architecture	No domain graphic available
Description	Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic).

ATRX_HUMAN
NC score	0.036380 (rank : 22)	θ value	0.0736092 (rank : 8)
Query Neighborhood Hits	57	Target Neighborhood Hits	842	Shared Neighborhood Hits	14
SwissProt Accessions	P46100, P51068, Q15886, Q59FB5, Q59H31, Q5H9A2, Q5JWI4, Q7Z2J1, Q9H0Z1, Q9NTS3	Gene names	ATRX, RAD54L, XH2
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf- HX).

NUMA1_HUMAN
NC score	0.034807 (rank : 23)	θ value	0.279714 (rank : 11)
Query Neighborhood Hits	57	Target Neighborhood Hits	1523	Shared Neighborhood Hits	23
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

T2EA_HUMAN
NC score	0.032380 (rank : 24)	θ value	4.03905 (rank : 33)
Query Neighborhood Hits	57	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	P29083, Q16103	Gene names	GTF2E1, TF2E1
Domain Architecture
Description	Transcription initiation factor IIE subunit alpha (TFIIE-alpha) (General transcription factor IIE 56 kDa subunit).

SFPQ_HUMAN
NC score	0.028606 (rank : 25)	θ value	0.813845 (rank : 20)
Query Neighborhood Hits	57	Target Neighborhood Hits	986	Shared Neighborhood Hits	18
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

CENPJ_HUMAN
NC score	0.028316 (rank : 26)	θ value	5.27518 (rank : 38)
Query Neighborhood Hits	57	Target Neighborhood Hits	721	Shared Neighborhood Hits	19
SwissProt Accessions	Q9HC77, Q5T6R5, Q96KS5, Q9C067	Gene names	CENPJ, CPAP, LAP, LIP1
Domain Architecture	No domain graphic available
Description	Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1).

DAZP1_MOUSE
NC score	0.028303 (rank : 27)	θ value	0.365318 (rank : 12)
Query Neighborhood Hits	57	Target Neighborhood Hits	313	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JII5	Gene names	Dazap1
Domain Architecture
Description	DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1).

GOGB1_HUMAN
NC score	0.027856 (rank : 28)	θ value	1.81305 (rank : 26)
Query Neighborhood Hits	57	Target Neighborhood Hits	2297	Shared Neighborhood Hits	26
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

SPTA1_MOUSE
NC score	0.027214 (rank : 29)	θ value	5.27518 (rank : 40)
Query Neighborhood Hits	57	Target Neighborhood Hits	675	Shared Neighborhood Hits	15
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

DAZP1_HUMAN
NC score	0.026757 (rank : 30)	θ value	1.38821 (rank : 23)
Query Neighborhood Hits	57	Target Neighborhood Hits	313	Shared Neighborhood Hits	7
SwissProt Accessions	Q96EP5, Q96MJ3, Q9NRR9	Gene names	DAZAP1
Domain Architecture
Description	DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1).

NUPL_HUMAN
NC score	0.025774 (rank : 31)	θ value	0.813845 (rank : 19)
Query Neighborhood Hits	57	Target Neighborhood Hits	68	Shared Neighborhood Hits	2
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).

H14_MOUSE
NC score	0.024661 (rank : 32)	θ value	3.0926 (rank : 28)
Query Neighborhood Hits	57	Target Neighborhood Hits	88	Shared Neighborhood Hits	3
SwissProt Accessions	P43274	Gene names	Hist1h1e, H1f4
Domain Architecture
Description	Histone H1.4 (H1 VAR.2) (H1e).

CDX1_HUMAN
NC score	0.023460 (rank : 33)	θ value	0.0431538 (rank : 5)
Query Neighborhood Hits	57	Target Neighborhood Hits	382	Shared Neighborhood Hits	4
SwissProt Accessions	P47902, Q4VAU4, Q9NYK8	Gene names	CDX1
Domain Architecture
Description	Homeobox protein CDX-1 (Caudal-type homeobox protein 1).

GOGA4_MOUSE
NC score	0.022468 (rank : 34)	θ value	6.88961 (rank : 43)
Query Neighborhood Hits	57	Target Neighborhood Hits	1939	Shared Neighborhood Hits	25
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

ARS2_HUMAN
NC score	0.022252 (rank : 35)	θ value	5.27518 (rank : 34)
Query Neighborhood Hits	57	Target Neighborhood Hits	186	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BXP5, O95808, Q9BWP6, Q9BXP4	Gene names	ARS2, ASR2
Domain Architecture
Description	Arsenite-resistance protein 2.

ARS2_MOUSE
NC score	0.022052 (rank : 36)	θ value	5.27518 (rank : 35)
Query Neighborhood Hits	57	Target Neighborhood Hits	212	Shared Neighborhood Hits	4
SwissProt Accessions	Q99MR6, Q99MR4, Q99MR5, Q99MR7	Gene names	Ars2, Asr2
Domain Architecture
Description	Arsenite-resistance protein 2.

PCNT_MOUSE
NC score	0.021969 (rank : 37)	θ value	8.99809 (rank : 55)
Query Neighborhood Hits	57	Target Neighborhood Hits	1207	Shared Neighborhood Hits	20
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

CN032_MOUSE
NC score	0.021183 (rank : 38)	θ value	6.88961 (rank : 42)
Query Neighborhood Hits	57	Target Neighborhood Hits	233	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BH93, Q3TF12, Q3TGL0, Q8CC90	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf32 homolog.

EF1D_MOUSE
NC score	0.020921 (rank : 39)	θ value	8.99809 (rank : 51)
Query Neighborhood Hits	57	Target Neighborhood Hits	50	Shared Neighborhood Hits	8
SwissProt Accessions	P57776, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5	Gene names	Eef1d
Domain Architecture
Description	Elongation factor 1-delta (EF-1-delta).

CE110_HUMAN
NC score	0.020181 (rank : 40)	θ value	8.99809 (rank : 48)
Query Neighborhood Hits	57	Target Neighborhood Hits	197	Shared Neighborhood Hits	10
SwissProt Accessions	O43303, O43335, Q68DV9, Q8NE13	Gene names	CEP110, CP110, KIAA0419
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 110 kDa (Cep110 protein).

ITSN2_MOUSE
NC score	0.019984 (rank : 41)	θ value	1.38821 (rank : 24)
Query Neighborhood Hits	57	Target Neighborhood Hits	1371	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

KIF22_HUMAN
NC score	0.019848 (rank : 42)	θ value	0.813845 (rank : 18)
Query Neighborhood Hits	57	Target Neighborhood Hits	110	Shared Neighborhood Hits	7
SwissProt Accessions	Q14807, O94814, Q9BT46	Gene names	KIF22, KID, KNSL4
Domain Architecture
Description	Kinesin-like protein KIF22 (Kinesin-like DNA-binding protein) (Kinesin-like protein 4).

ATX2_HUMAN
NC score	0.018488 (rank : 43)	θ value	5.27518 (rank : 36)
Query Neighborhood Hits	57	Target Neighborhood Hits	375	Shared Neighborhood Hits	6
SwissProt Accessions	Q99700, Q6ZQZ7, Q99493	Gene names	ATXN2, ATX2, SCA2, TNRC13
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein).

CASL_MOUSE
NC score	0.018243 (rank : 44)	θ value	5.27518 (rank : 37)
Query Neighborhood Hits	57	Target Neighborhood Hits	225	Shared Neighborhood Hits	7
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

MLL2_HUMAN
NC score	0.016968 (rank : 45)	θ value	3.0926 (rank : 29)
Query Neighborhood Hits	57	Target Neighborhood Hits	1788	Shared Neighborhood Hits	27
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

AMPH_HUMAN
NC score	0.016860 (rank : 46)	θ value	6.88961 (rank : 41)
Query Neighborhood Hits	57	Target Neighborhood Hits	455	Shared Neighborhood Hits	8
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

KAD7_MOUSE
NC score	0.016604 (rank : 47)	θ value	8.99809 (rank : 53)
Query Neighborhood Hits	57	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D2H2, Q8BVH3	Gene names	Ak7
Domain Architecture
Description	Putative adenylate kinase 7 (EC 2.7.4.3).

NCOA2_HUMAN
NC score	0.016552 (rank : 48)	θ value	5.27518 (rank : 39)
Query Neighborhood Hits	57	Target Neighborhood Hits	281	Shared Neighborhood Hits	5
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

AKAP3_HUMAN
NC score	0.016078 (rank : 49)	θ value	4.03905 (rank : 30)
Query Neighborhood Hits	57	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	O75969, O75945, Q9UM61	Gene names	AKAP3, AKAP110, SOB1
Domain Architecture
Description	A-kinase anchor protein 3 (Protein kinase A-anchoring protein 3) (PRKA3) (A-kinase anchor protein 110 kDa) (AKAP 110) (Sperm oocyte- binding protein) (Fibrousheathin-1) (Fibrousheathin I) (Fibrous sheath protein of 95 kDa) (FSP95).

LIPA2_MOUSE
NC score	0.015902 (rank : 50)	θ value	8.99809 (rank : 54)
Query Neighborhood Hits	57	Target Neighborhood Hits	1282	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BSS9, Q8BN73	Gene names	Ppfia2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

TLN1_HUMAN
NC score	0.013937 (rank : 51)	θ value	6.88961 (rank : 45)
Query Neighborhood Hits	57	Target Neighborhood Hits	218	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

TLN1_MOUSE
NC score	0.013664 (rank : 52)	θ value	6.88961 (rank : 46)
Query Neighborhood Hits	57	Target Neighborhood Hits	213	Shared Neighborhood Hits	7
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

E41L2_MOUSE
NC score	0.012919 (rank : 53)	θ value	4.03905 (rank : 31)
Query Neighborhood Hits	57	Target Neighborhood Hits	459	Shared Neighborhood Hits	13
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

DYN3_HUMAN
NC score	0.011376 (rank : 54)	θ value	8.99809 (rank : 50)
Query Neighborhood Hits	57	Target Neighborhood Hits	158	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

SMCA4_HUMAN
NC score	0.011187 (rank : 55)	θ value	4.03905 (rank : 32)
Query Neighborhood Hits	57	Target Neighborhood Hits	597	Shared Neighborhood Hits	8
SwissProt Accessions	P51532, O95052, Q9HBD3	Gene names	SMARCA4, BRG1, SNF2B, SNF2L4
Domain Architecture
Description	Probable global transcription activator SNF2L4 (EC 3.6.1.-) (ATP- dependent helicase SMARCA4) (SNF2-beta) (BRG-1 protein) (Mitotic growth and transcription activator) (Brahma protein homolog 1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4).

FOXQ1_HUMAN
NC score	0.010468 (rank : 56)	θ value	1.81305 (rank : 25)
Query Neighborhood Hits	57	Target Neighborhood Hits	115	Shared Neighborhood Hits	3
SwissProt Accessions	Q9C009, Q9NS06	Gene names	FOXQ1, HFH1
Domain Architecture
Description	Forkhead box protein Q1 (Hepatocyte nuclear factor 3 forkhead homolog 1) (HNF-3/forkhead-like protein 1) (HFH-1).

DYN2_HUMAN
NC score	0.008516 (rank : 57)	θ value	8.99809 (rank : 49)
Query Neighborhood Hits	57	Target Neighborhood Hits	112	Shared Neighborhood Hits	4
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

AINX_MOUSE
NC score	0.007316 (rank : 58)	θ value	8.99809 (rank : 47)
Query Neighborhood Hits	57	Target Neighborhood Hits	448	Shared Neighborhood Hits	13
SwissProt Accessions	P46660, Q61958, Q8VCW5	Gene names	Ina
Domain Architecture
Description	Alpha-internexin (Alpha-Inx) (66 kDa neurofilament protein) (Neurofilament-66) (NF-66).

MYPT1_MOUSE
NC score	0.006456 (rank : 59)	θ value	6.88961 (rank : 44)
Query Neighborhood Hits	57	Target Neighborhood Hits	539	Shared Neighborhood Hits	8
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

FOXB1_MOUSE
NC score	0.005255 (rank : 60)	θ value	8.99809 (rank : 52)
Query Neighborhood Hits	57	Target Neighborhood Hits	125	Shared Neighborhood Hits	3
SwissProt Accessions	Q64732, O08753	Gene names	Foxb1, Fkh5, Foxb1a, Foxb1b, Mf3
Domain Architecture
Description	Forkhead box protein B1 (Transcription factor FKH-5).

MK07_MOUSE
NC score	0.001658 (rank : 61)	θ value	1.81305 (rank : 27)
Query Neighborhood Hits	57	Target Neighborhood Hits	1054	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).