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Network neighborhood for query Sequence : COA1_HUMAN

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COA1_HUMAN
SwissProt Accessions	Q13085	Gene names	ACACA, ACAC, ACC1, ACCA
Domain Architecture
Description	Acetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

COA1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	49	Target Neighborhood Hits	49	Shared Neighborhood Hits	49
SwissProt Accessions	Q13085	Gene names	ACACA, ACAC, ACC1, ACCA
Domain Architecture
Description	Acetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)].

COA2_HUMAN
θ value	0 (rank : 2)	NC score	0.968167 (rank : 2)
Query Neighborhood Hits	49	Target Neighborhood Hits	184	Shared Neighborhood Hits	17
SwissProt Accessions	O00763, Q16852	Gene names	ACACB, ACC2, ACCB
Domain Architecture
Description	Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) [Includes: Biotin carboxylase (EC 6.3.4.14)].

PCCA_MOUSE
θ value	1.66577e-62 (rank : 3)	NC score	0.824099 (rank : 4)
Query Neighborhood Hits	49	Target Neighborhood Hits	18	Shared Neighborhood Hits	11
SwissProt Accessions	Q91ZA3, Q80VU5, Q922N3	Gene names	Pcca
Domain Architecture	No domain graphic available
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

PCCA_HUMAN
θ value	4.84666e-62 (rank : 4)	NC score	0.824433 (rank : 3)
Query Neighborhood Hits	49	Target Neighborhood Hits	22	Shared Neighborhood Hits	11
SwissProt Accessions	P05165, Q15979	Gene names	PCCA
Domain Architecture
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

MCCA_MOUSE
θ value	2.40537e-61 (rank : 5)	NC score	0.821863 (rank : 5)
Query Neighborhood Hits	49	Target Neighborhood Hits	18	Shared Neighborhood Hits	13
SwissProt Accessions	Q99MR8, Q3TGU0, Q9D8R2	Gene names	Mccc1, Mcca
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

MCCA_HUMAN
θ value	6.55044e-59 (rank : 6)	NC score	0.821243 (rank : 6)
Query Neighborhood Hits	49	Target Neighborhood Hits	26	Shared Neighborhood Hits	13
SwissProt Accessions	Q96RQ3, Q59ES4, Q9H959, Q9NS97	Gene names	MCCC1, MCCA
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

PYC_MOUSE
θ value	9.45883e-58 (rank : 7)	NC score	0.796349 (rank : 7)
Query Neighborhood Hits	49	Target Neighborhood Hits	25	Shared Neighborhood Hits	11
SwissProt Accessions	Q05920	Gene names	Pc, Pcx
Domain Architecture
Description	Pyruvate carboxylase, mitochondrial precursor (EC 6.4.1.1) (Pyruvic carboxylase) (PCB).

PYC_HUMAN
θ value	6.13105e-57 (rank : 8)	NC score	0.795358 (rank : 8)
Query Neighborhood Hits	49	Target Neighborhood Hits	25	Shared Neighborhood Hits	11
SwissProt Accessions	P11498, Q16705	Gene names	PC
Domain Architecture
Description	Pyruvate carboxylase, mitochondrial precursor (EC 6.4.1.1) (Pyruvic carboxylase) (PCB).

PCCB_MOUSE
θ value	4.91457e-14 (rank : 9)	NC score	0.355977 (rank : 12)
Query Neighborhood Hits	49	Target Neighborhood Hits	8	Shared Neighborhood Hits	5
SwissProt Accessions	Q99MN9	Gene names	Pccb
Domain Architecture	No domain graphic available
Description	Propionyl-CoA carboxylase beta chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit beta) (Propanoyl-CoA:carbon dioxide ligase subunit beta).

PCCB_HUMAN
θ value	4.16044e-13 (rank : 10)	NC score	0.350499 (rank : 13)
Query Neighborhood Hits	49	Target Neighborhood Hits	8	Shared Neighborhood Hits	5
SwissProt Accessions	P05166, Q16813	Gene names	PCCB
Domain Architecture
Description	Propionyl-CoA carboxylase beta chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit beta) (Propanoyl-CoA:carbon dioxide ligase subunit beta).

PYR1_HUMAN
θ value	7.84624e-12 (rank : 11)	NC score	0.396358 (rank : 10)
Query Neighborhood Hits	49	Target Neighborhood Hits	119	Shared Neighborhood Hits	13
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].

CPSM_HUMAN
θ value	5.08577e-11 (rank : 12)	NC score	0.396058 (rank : 11)
Query Neighborhood Hits	49	Target Neighborhood Hits	27	Shared Neighborhood Hits	11
SwissProt Accessions	P31327, O43774, Q7Z5I5	Gene names	CPS1
Domain Architecture
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

CPSM_MOUSE
θ value	6.64225e-11 (rank : 13)	NC score	0.396681 (rank : 9)
Query Neighborhood Hits	49	Target Neighborhood Hits	32	Shared Neighborhood Hits	11
SwissProt Accessions	Q8C196, Q6NX75	Gene names	Cps1
Domain Architecture	No domain graphic available
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

MCCC2_HUMAN
θ value	0.00102713 (rank : 14)	NC score	0.239731 (rank : 14)
Query Neighborhood Hits	49	Target Neighborhood Hits	8	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HCC0, Q96C27, Q9Y4L7	Gene names	MCCC2, MCCB
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial precursor (EC 6.4.1.4) (3-Methylcrotonyl-CoA carboxylase 2) (MCCase subunit beta) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta) (3- Methylcrotonyl-CoA carboxylase non-biotin-containing subunit).

TLR3_HUMAN
θ value	0.0431538 (rank : 15)	NC score	0.018904 (rank : 29)
Query Neighborhood Hits	49	Target Neighborhood Hits	323	Shared Neighborhood Hits	4
SwissProt Accessions	O15455	Gene names	TLR3
Domain Architecture
Description	Toll-like receptor 3 precursor (CD283 antigen).

ODPX_HUMAN
θ value	0.47712 (rank : 16)	NC score	0.054680 (rank : 15)
Query Neighborhood Hits	49	Target Neighborhood Hits	24	Shared Neighborhood Hits	5
SwissProt Accessions	O00330, O60221, Q96FV8, Q99783	Gene names	PDHX, PDX1
Domain Architecture
Description	Pyruvate dehydrogenase protein X component, mitochondrial precursor (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (Lipoyl-containing pyruvate dehydrogenase complex component X) (E3-binding protein) (E3BP) (proX).

UBAP1_HUMAN
θ value	0.813845 (rank : 17)	NC score	0.042276 (rank : 19)
Query Neighborhood Hits	49	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZ09, Q4V759, Q5T7B3, Q6FI75, Q8NC52, Q8NCG6, Q8NCH9	Gene names	UBAP1
Domain Architecture	No domain graphic available
Description	Ubiquitin-associated protein 1 (UBAP).

ODPX_MOUSE
θ value	1.06291 (rank : 18)	NC score	0.053320 (rank : 16)
Query Neighborhood Hits	49	Target Neighborhood Hits	32	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BKZ9	Gene names	Pdhx
Domain Architecture	No domain graphic available
Description	Pyruvate dehydrogenase protein X component, mitochondrial precursor (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (Lipoyl-containing pyruvate dehydrogenase complex component X).

CTR9_HUMAN
θ value	1.38821 (rank : 19)	NC score	0.027783 (rank : 21)
Query Neighborhood Hits	49	Target Neighborhood Hits	383	Shared Neighborhood Hits	5
SwissProt Accessions	Q6PD62, Q15015	Gene names	CTR9, KIAA0155, SH2BP1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1).

CTR9_MOUSE
θ value	1.38821 (rank : 20)	NC score	0.027229 (rank : 22)
Query Neighborhood Hits	49	Target Neighborhood Hits	427	Shared Neighborhood Hits	5
SwissProt Accessions	Q62018, Q3UFF5, Q3UY40, Q66JX4, Q7TPS6, Q8BND9, Q8BRD1, Q8C9W7, Q8C9Y3, Q8CHI1	Gene names	Ctr9, Kiaa0155, Sh2bp1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) (Tetratricopeptide repeat-containing, SH2-binding phosphoprotein of 150 kDa) (TPR-containing, SH2-binding phosphoprotein of 150 kDa) (p150TSP).

DYN2_HUMAN
θ value	1.38821 (rank : 21)	NC score	0.020080 (rank : 26)
Query Neighborhood Hits	49	Target Neighborhood Hits	112	Shared Neighborhood Hits	5
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

DYN2_MOUSE
θ value	1.38821 (rank : 22)	NC score	0.018773 (rank : 30)
Query Neighborhood Hits	49	Target Neighborhood Hits	104	Shared Neighborhood Hits	3
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

GLIS3_MOUSE
θ value	1.38821 (rank : 23)	NC score	0.001681 (rank : 48)
Query Neighborhood Hits	49	Target Neighborhood Hits	861	Shared Neighborhood Hits	3
SwissProt Accessions	Q6XP49, Q8BI60	Gene names	Glis3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS3 (GLI-similar 3).

NFYA_HUMAN
θ value	1.38821 (rank : 24)	NC score	0.045233 (rank : 18)
Query Neighborhood Hits	49	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	P23511, Q8IXU0	Gene names	NFYA
Domain Architecture
Description	Nuclear transcription factor Y subunit alpha (Nuclear transcription factor Y subunit A) (NF-YA) (CAAT-box DNA-binding protein subunit A).

NFYA_MOUSE
θ value	1.38821 (rank : 25)	NC score	0.045323 (rank : 17)
Query Neighborhood Hits	49	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	P23708	Gene names	Nfya
Domain Architecture
Description	Nuclear transcription factor Y subunit alpha (Nuclear transcription factor Y subunit A) (NF-YA) (CAAT-box DNA-binding protein subunit A).

RB27B_HUMAN
θ value	1.38821 (rank : 26)	NC score	0.006572 (rank : 40)
Query Neighborhood Hits	49	Target Neighborhood Hits	281	Shared Neighborhood Hits	3
SwissProt Accessions	O00194, Q9BZB6	Gene names	RAB27B
Domain Architecture
Description	Ras-related protein Rab-27B (C25KG).

RB27B_MOUSE
θ value	1.81305 (rank : 27)	NC score	0.006173 (rank : 41)
Query Neighborhood Hits	49	Target Neighborhood Hits	276	Shared Neighborhood Hits	3
SwissProt Accessions	Q99P58, Q8CIX0	Gene names	Rab27b
Domain Architecture
Description	Ras-related protein Rab-27B.

TSC2_HUMAN
θ value	1.81305 (rank : 28)	NC score	0.019614 (rank : 27)
Query Neighborhood Hits	49	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	P49815, O75275, Q8TAZ1	Gene names	TSC2
Domain Architecture
Description	Tuberin (Tuberous sclerosis 2 protein).

UBAP1_MOUSE
θ value	1.81305 (rank : 29)	NC score	0.038226 (rank : 20)
Query Neighborhood Hits	49	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BH48, Q8BQ80, Q8BSW6, Q9D749, Q9ERV5	Gene names	Ubap1
Domain Architecture	No domain graphic available
Description	Ubiquitin-associated protein 1 (UBAP) (Ubiquitin-associated protein NAG20).

CCD37_MOUSE
θ value	2.36792 (rank : 30)	NC score	0.025361 (rank : 23)
Query Neighborhood Hits	49	Target Neighborhood Hits	199	Shared Neighborhood Hits	5
SwissProt Accessions	Q80VN0, Q6AXD6	Gene names	Ccdc37
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 37.

ITSN1_MOUSE
θ value	2.36792 (rank : 31)	NC score	0.002673 (rank : 46)
Query Neighborhood Hits	49	Target Neighborhood Hits	1669	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

TNR6A_HUMAN
θ value	2.36792 (rank : 32)	NC score	0.019416 (rank : 28)
Query Neighborhood Hits	49	Target Neighborhood Hits	343	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NDV7, O15408, Q658L5, Q6NVB5, Q8NEZ0, Q8TBT8, Q8TCR0, Q9NV59, Q9P268	Gene names	TNRC6A, CAGH26, KIAA1460, TNRC6
Domain Architecture	No domain graphic available
Description	Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (Glycine-tryptophan protein of 182 kDa) (GW182 autoantigen) (Protein GW1) (EMSY interactor protein).

NMT1_HUMAN
θ value	3.0926 (rank : 33)	NC score	0.021067 (rank : 25)
Query Neighborhood Hits	49	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	P30419, Q9UE09	Gene names	NMT1, NMT
Domain Architecture
Description	Glycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97) (Peptide N- myristoyltransferase 1) (Myristoyl-CoA:protein N-myristoyltransferase 1) (NMT 1) (Type I N-myristoyltransferase).

NMT1_MOUSE
θ value	3.0926 (rank : 34)	NC score	0.021086 (rank : 24)
Query Neighborhood Hits	49	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	O70310	Gene names	Nmt1
Domain Architecture
Description	Glycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97) (Peptide N- myristoyltransferase 1) (Myristoyl-CoA:protein N-myristoyltransferase 1) (NMT 1) (Type I N-myristoyltransferase).

LYST_MOUSE
θ value	4.03905 (rank : 35)	NC score	0.009097 (rank : 36)
Query Neighborhood Hits	49	Target Neighborhood Hits	286	Shared Neighborhood Hits	3
SwissProt Accessions	P97412, Q62403, Q8VBS6	Gene names	Lyst, Bg, Chs1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige protein) (CHS1 homolog).

STK6_HUMAN
θ value	4.03905 (rank : 36)	NC score	-0.000911 (rank : 49)
Query Neighborhood Hits	49	Target Neighborhood Hits	916	Shared Neighborhood Hits	4
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

FMN2_HUMAN
θ value	5.27518 (rank : 37)	NC score	0.008334 (rank : 37)
Query Neighborhood Hits	49	Target Neighborhood Hits	484	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

MAST1_HUMAN
θ value	5.27518 (rank : 38)	NC score	0.001927 (rank : 47)
Query Neighborhood Hits	49	Target Neighborhood Hits	1146	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

FSTL5_MOUSE
θ value	6.88961 (rank : 39)	NC score	0.004057 (rank : 42)
Query Neighborhood Hits	49	Target Neighborhood Hits	355	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BFR2, Q80TG3, Q8C4T3	Gene names	Fstl5, Kiaa1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5) (m- D/Bsp120I 1-2).

POL2_MOUSE
θ value	6.88961 (rank : 40)	NC score	0.011766 (rank : 33)
Query Neighborhood Hits	49	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	P11369, Q60713, Q61787	Gene names	Pol
Domain Architecture
Description	Retrovirus-related Pol polyprotein LINE-1 (Long interspersed element- 1) (L1) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease].

RXFP2_MOUSE
θ value	6.88961 (rank : 41)	NC score	0.003418 (rank : 45)
Query Neighborhood Hits	49	Target Neighborhood Hits	760	Shared Neighborhood Hits	4
SwissProt Accessions	Q91ZZ5	Gene names	Rxfp2, Gpr106, Great, Lgr8
Domain Architecture
Description	Relaxin receptor 2 (Relaxin family peptide receptor 2) (Leucine-rich repeat-containing G-protein coupled receptor 8) (G-protein coupled receptor affecting testicular descent) (G-protein coupled receptor 106).

SFR11_HUMAN
θ value	6.88961 (rank : 42)	NC score	0.012097 (rank : 32)
Query Neighborhood Hits	49	Target Neighborhood Hits	246	Shared Neighborhood Hits	4
SwissProt Accessions	Q05519	Gene names	SFRS11
Domain Architecture
Description	Splicing factor arginine/serine-rich 11 (Arginine-rich 54 kDa nuclear protein) (p54).

TLR3_MOUSE
θ value	6.88961 (rank : 43)	NC score	0.011075 (rank : 34)
Query Neighborhood Hits	49	Target Neighborhood Hits	298	Shared Neighborhood Hits	4
SwissProt Accessions	Q99MB1, Q91ZM4	Gene names	Tlr3
Domain Architecture
Description	Toll-like receptor 3 precursor (CD283 antigen).

ARMC4_HUMAN
θ value	8.99809 (rank : 44)	NC score	0.010715 (rank : 35)
Query Neighborhood Hits	49	Target Neighborhood Hits	88	Shared Neighborhood Hits	3
SwissProt Accessions	Q5T2S8, Q9H0C0	Gene names	ARMC4
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing protein 4.

CAN12_MOUSE
θ value	8.99809 (rank : 45)	NC score	0.003987 (rank : 43)
Query Neighborhood Hits	49	Target Neighborhood Hits	56	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ER56, Q9ER53, Q9ER54, Q9ER55	Gene names	Capn12
Domain Architecture
Description	Calpain-12 (EC 3.4.22.-).

COPG_HUMAN
θ value	8.99809 (rank : 46)	NC score	0.007703 (rank : 38)
Query Neighborhood Hits	49	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y678	Gene names	COPG
Domain Architecture
Description	Coatomer subunit gamma (Gamma-coat protein) (Gamma-COP).

NPBL_MOUSE
θ value	8.99809 (rank : 47)	NC score	0.018020 (rank : 31)
Query Neighborhood Hits	49	Target Neighborhood Hits	1041	Shared Neighborhood Hits	9
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

PDE7A_HUMAN
θ value	8.99809 (rank : 48)	NC score	0.003777 (rank : 44)
Query Neighborhood Hits	49	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q13946, O15380	Gene names	PDE7A
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (HCP1) (TM22).

RPGF1_HUMAN
θ value	8.99809 (rank : 49)	NC score	0.007183 (rank : 39)
Query Neighborhood Hits	49	Target Neighborhood Hits	262	Shared Neighborhood Hits	5
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

Hits sorted by NC score

COA1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	49	Target Neighborhood Hits	49	Shared Neighborhood Hits	49
SwissProt Accessions	Q13085	Gene names	ACACA, ACAC, ACC1, ACCA
Domain Architecture
Description	Acetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)].

COA2_HUMAN
NC score	0.968167 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	49	Target Neighborhood Hits	184	Shared Neighborhood Hits	17
SwissProt Accessions	O00763, Q16852	Gene names	ACACB, ACC2, ACCB
Domain Architecture
Description	Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) [Includes: Biotin carboxylase (EC 6.3.4.14)].

PCCA_HUMAN
NC score	0.824433 (rank : 3)	θ value	4.84666e-62 (rank : 4)
Query Neighborhood Hits	49	Target Neighborhood Hits	22	Shared Neighborhood Hits	11
SwissProt Accessions	P05165, Q15979	Gene names	PCCA
Domain Architecture
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

PCCA_MOUSE
NC score	0.824099 (rank : 4)	θ value	1.66577e-62 (rank : 3)
Query Neighborhood Hits	49	Target Neighborhood Hits	18	Shared Neighborhood Hits	11
SwissProt Accessions	Q91ZA3, Q80VU5, Q922N3	Gene names	Pcca
Domain Architecture	No domain graphic available
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

MCCA_MOUSE
NC score	0.821863 (rank : 5)	θ value	2.40537e-61 (rank : 5)
Query Neighborhood Hits	49	Target Neighborhood Hits	18	Shared Neighborhood Hits	13
SwissProt Accessions	Q99MR8, Q3TGU0, Q9D8R2	Gene names	Mccc1, Mcca
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

MCCA_HUMAN
NC score	0.821243 (rank : 6)	θ value	6.55044e-59 (rank : 6)
Query Neighborhood Hits	49	Target Neighborhood Hits	26	Shared Neighborhood Hits	13
SwissProt Accessions	Q96RQ3, Q59ES4, Q9H959, Q9NS97	Gene names	MCCC1, MCCA
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

PYC_MOUSE
NC score	0.796349 (rank : 7)	θ value	9.45883e-58 (rank : 7)
Query Neighborhood Hits	49	Target Neighborhood Hits	25	Shared Neighborhood Hits	11
SwissProt Accessions	Q05920	Gene names	Pc, Pcx
Domain Architecture
Description	Pyruvate carboxylase, mitochondrial precursor (EC 6.4.1.1) (Pyruvic carboxylase) (PCB).

PYC_HUMAN
NC score	0.795358 (rank : 8)	θ value	6.13105e-57 (rank : 8)
Query Neighborhood Hits	49	Target Neighborhood Hits	25	Shared Neighborhood Hits	11
SwissProt Accessions	P11498, Q16705	Gene names	PC
Domain Architecture
Description	Pyruvate carboxylase, mitochondrial precursor (EC 6.4.1.1) (Pyruvic carboxylase) (PCB).

CPSM_MOUSE
NC score	0.396681 (rank : 9)	θ value	6.64225e-11 (rank : 13)
Query Neighborhood Hits	49	Target Neighborhood Hits	32	Shared Neighborhood Hits	11
SwissProt Accessions	Q8C196, Q6NX75	Gene names	Cps1
Domain Architecture	No domain graphic available
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

PYR1_HUMAN
NC score	0.396358 (rank : 10)	θ value	7.84624e-12 (rank : 11)
Query Neighborhood Hits	49	Target Neighborhood Hits	119	Shared Neighborhood Hits	13
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].

CPSM_HUMAN
NC score	0.396058 (rank : 11)	θ value	5.08577e-11 (rank : 12)
Query Neighborhood Hits	49	Target Neighborhood Hits	27	Shared Neighborhood Hits	11
SwissProt Accessions	P31327, O43774, Q7Z5I5	Gene names	CPS1
Domain Architecture
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

PCCB_MOUSE
NC score	0.355977 (rank : 12)	θ value	4.91457e-14 (rank : 9)
Query Neighborhood Hits	49	Target Neighborhood Hits	8	Shared Neighborhood Hits	5
SwissProt Accessions	Q99MN9	Gene names	Pccb
Domain Architecture	No domain graphic available
Description	Propionyl-CoA carboxylase beta chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit beta) (Propanoyl-CoA:carbon dioxide ligase subunit beta).

PCCB_HUMAN
NC score	0.350499 (rank : 13)	θ value	4.16044e-13 (rank : 10)
Query Neighborhood Hits	49	Target Neighborhood Hits	8	Shared Neighborhood Hits	5
SwissProt Accessions	P05166, Q16813	Gene names	PCCB
Domain Architecture
Description	Propionyl-CoA carboxylase beta chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit beta) (Propanoyl-CoA:carbon dioxide ligase subunit beta).

MCCC2_HUMAN
NC score	0.239731 (rank : 14)	θ value	0.00102713 (rank : 14)
Query Neighborhood Hits	49	Target Neighborhood Hits	8	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HCC0, Q96C27, Q9Y4L7	Gene names	MCCC2, MCCB
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial precursor (EC 6.4.1.4) (3-Methylcrotonyl-CoA carboxylase 2) (MCCase subunit beta) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta) (3- Methylcrotonyl-CoA carboxylase non-biotin-containing subunit).

ODPX_HUMAN
NC score	0.054680 (rank : 15)	θ value	0.47712 (rank : 16)
Query Neighborhood Hits	49	Target Neighborhood Hits	24	Shared Neighborhood Hits	5
SwissProt Accessions	O00330, O60221, Q96FV8, Q99783	Gene names	PDHX, PDX1
Domain Architecture
Description	Pyruvate dehydrogenase protein X component, mitochondrial precursor (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (Lipoyl-containing pyruvate dehydrogenase complex component X) (E3-binding protein) (E3BP) (proX).

ODPX_MOUSE
NC score	0.053320 (rank : 16)	θ value	1.06291 (rank : 18)
Query Neighborhood Hits	49	Target Neighborhood Hits	32	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BKZ9	Gene names	Pdhx
Domain Architecture	No domain graphic available
Description	Pyruvate dehydrogenase protein X component, mitochondrial precursor (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (Lipoyl-containing pyruvate dehydrogenase complex component X).

NFYA_MOUSE
NC score	0.045323 (rank : 17)	θ value	1.38821 (rank : 25)
Query Neighborhood Hits	49	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	P23708	Gene names	Nfya
Domain Architecture
Description	Nuclear transcription factor Y subunit alpha (Nuclear transcription factor Y subunit A) (NF-YA) (CAAT-box DNA-binding protein subunit A).

NFYA_HUMAN
NC score	0.045233 (rank : 18)	θ value	1.38821 (rank : 24)
Query Neighborhood Hits	49	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	P23511, Q8IXU0	Gene names	NFYA
Domain Architecture
Description	Nuclear transcription factor Y subunit alpha (Nuclear transcription factor Y subunit A) (NF-YA) (CAAT-box DNA-binding protein subunit A).

UBAP1_HUMAN
NC score	0.042276 (rank : 19)	θ value	0.813845 (rank : 17)
Query Neighborhood Hits	49	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZ09, Q4V759, Q5T7B3, Q6FI75, Q8NC52, Q8NCG6, Q8NCH9	Gene names	UBAP1
Domain Architecture	No domain graphic available
Description	Ubiquitin-associated protein 1 (UBAP).

UBAP1_MOUSE
NC score	0.038226 (rank : 20)	θ value	1.81305 (rank : 29)
Query Neighborhood Hits	49	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BH48, Q8BQ80, Q8BSW6, Q9D749, Q9ERV5	Gene names	Ubap1
Domain Architecture	No domain graphic available
Description	Ubiquitin-associated protein 1 (UBAP) (Ubiquitin-associated protein NAG20).

CTR9_HUMAN
NC score	0.027783 (rank : 21)	θ value	1.38821 (rank : 19)
Query Neighborhood Hits	49	Target Neighborhood Hits	383	Shared Neighborhood Hits	5
SwissProt Accessions	Q6PD62, Q15015	Gene names	CTR9, KIAA0155, SH2BP1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1).

CTR9_MOUSE
NC score	0.027229 (rank : 22)	θ value	1.38821 (rank : 20)
Query Neighborhood Hits	49	Target Neighborhood Hits	427	Shared Neighborhood Hits	5
SwissProt Accessions	Q62018, Q3UFF5, Q3UY40, Q66JX4, Q7TPS6, Q8BND9, Q8BRD1, Q8C9W7, Q8C9Y3, Q8CHI1	Gene names	Ctr9, Kiaa0155, Sh2bp1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) (Tetratricopeptide repeat-containing, SH2-binding phosphoprotein of 150 kDa) (TPR-containing, SH2-binding phosphoprotein of 150 kDa) (p150TSP).

CCD37_MOUSE
NC score	0.025361 (rank : 23)	θ value	2.36792 (rank : 30)
Query Neighborhood Hits	49	Target Neighborhood Hits	199	Shared Neighborhood Hits	5
SwissProt Accessions	Q80VN0, Q6AXD6	Gene names	Ccdc37
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 37.

NMT1_MOUSE
NC score	0.021086 (rank : 24)	θ value	3.0926 (rank : 34)
Query Neighborhood Hits	49	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	O70310	Gene names	Nmt1
Domain Architecture
Description	Glycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97) (Peptide N- myristoyltransferase 1) (Myristoyl-CoA:protein N-myristoyltransferase 1) (NMT 1) (Type I N-myristoyltransferase).

NMT1_HUMAN
NC score	0.021067 (rank : 25)	θ value	3.0926 (rank : 33)
Query Neighborhood Hits	49	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	P30419, Q9UE09	Gene names	NMT1, NMT
Domain Architecture
Description	Glycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97) (Peptide N- myristoyltransferase 1) (Myristoyl-CoA:protein N-myristoyltransferase 1) (NMT 1) (Type I N-myristoyltransferase).

DYN2_HUMAN
NC score	0.020080 (rank : 26)	θ value	1.38821 (rank : 21)
Query Neighborhood Hits	49	Target Neighborhood Hits	112	Shared Neighborhood Hits	5
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

TSC2_HUMAN
NC score	0.019614 (rank : 27)	θ value	1.81305 (rank : 28)
Query Neighborhood Hits	49	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	P49815, O75275, Q8TAZ1	Gene names	TSC2
Domain Architecture
Description	Tuberin (Tuberous sclerosis 2 protein).

TNR6A_HUMAN
NC score	0.019416 (rank : 28)	θ value	2.36792 (rank : 32)
Query Neighborhood Hits	49	Target Neighborhood Hits	343	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NDV7, O15408, Q658L5, Q6NVB5, Q8NEZ0, Q8TBT8, Q8TCR0, Q9NV59, Q9P268	Gene names	TNRC6A, CAGH26, KIAA1460, TNRC6
Domain Architecture	No domain graphic available
Description	Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (Glycine-tryptophan protein of 182 kDa) (GW182 autoantigen) (Protein GW1) (EMSY interactor protein).

TLR3_HUMAN
NC score	0.018904 (rank : 29)	θ value	0.0431538 (rank : 15)
Query Neighborhood Hits	49	Target Neighborhood Hits	323	Shared Neighborhood Hits	4
SwissProt Accessions	O15455	Gene names	TLR3
Domain Architecture
Description	Toll-like receptor 3 precursor (CD283 antigen).

DYN2_MOUSE
NC score	0.018773 (rank : 30)	θ value	1.38821 (rank : 22)
Query Neighborhood Hits	49	Target Neighborhood Hits	104	Shared Neighborhood Hits	3
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

NPBL_MOUSE
NC score	0.018020 (rank : 31)	θ value	8.99809 (rank : 47)
Query Neighborhood Hits	49	Target Neighborhood Hits	1041	Shared Neighborhood Hits	9
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

SFR11_HUMAN
NC score	0.012097 (rank : 32)	θ value	6.88961 (rank : 42)
Query Neighborhood Hits	49	Target Neighborhood Hits	246	Shared Neighborhood Hits	4
SwissProt Accessions	Q05519	Gene names	SFRS11
Domain Architecture
Description	Splicing factor arginine/serine-rich 11 (Arginine-rich 54 kDa nuclear protein) (p54).

POL2_MOUSE
NC score	0.011766 (rank : 33)	θ value	6.88961 (rank : 40)
Query Neighborhood Hits	49	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	P11369, Q60713, Q61787	Gene names	Pol
Domain Architecture
Description	Retrovirus-related Pol polyprotein LINE-1 (Long interspersed element- 1) (L1) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease].

TLR3_MOUSE
NC score	0.011075 (rank : 34)	θ value	6.88961 (rank : 43)
Query Neighborhood Hits	49	Target Neighborhood Hits	298	Shared Neighborhood Hits	4
SwissProt Accessions	Q99MB1, Q91ZM4	Gene names	Tlr3
Domain Architecture
Description	Toll-like receptor 3 precursor (CD283 antigen).

ARMC4_HUMAN
NC score	0.010715 (rank : 35)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	49	Target Neighborhood Hits	88	Shared Neighborhood Hits	3
SwissProt Accessions	Q5T2S8, Q9H0C0	Gene names	ARMC4
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing protein 4.

LYST_MOUSE
NC score	0.009097 (rank : 36)	θ value	4.03905 (rank : 35)
Query Neighborhood Hits	49	Target Neighborhood Hits	286	Shared Neighborhood Hits	3
SwissProt Accessions	P97412, Q62403, Q8VBS6	Gene names	Lyst, Bg, Chs1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige protein) (CHS1 homolog).

FMN2_HUMAN
NC score	0.008334 (rank : 37)	θ value	5.27518 (rank : 37)
Query Neighborhood Hits	49	Target Neighborhood Hits	484	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

COPG_HUMAN
NC score	0.007703 (rank : 38)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	49	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y678	Gene names	COPG
Domain Architecture
Description	Coatomer subunit gamma (Gamma-coat protein) (Gamma-COP).

RPGF1_HUMAN
NC score	0.007183 (rank : 39)	θ value	8.99809 (rank : 49)
Query Neighborhood Hits	49	Target Neighborhood Hits	262	Shared Neighborhood Hits	5
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

RB27B_HUMAN
NC score	0.006572 (rank : 40)	θ value	1.38821 (rank : 26)
Query Neighborhood Hits	49	Target Neighborhood Hits	281	Shared Neighborhood Hits	3
SwissProt Accessions	O00194, Q9BZB6	Gene names	RAB27B
Domain Architecture
Description	Ras-related protein Rab-27B (C25KG).

RB27B_MOUSE
NC score	0.006173 (rank : 41)	θ value	1.81305 (rank : 27)
Query Neighborhood Hits	49	Target Neighborhood Hits	276	Shared Neighborhood Hits	3
SwissProt Accessions	Q99P58, Q8CIX0	Gene names	Rab27b
Domain Architecture
Description	Ras-related protein Rab-27B.

FSTL5_MOUSE
NC score	0.004057 (rank : 42)	θ value	6.88961 (rank : 39)
Query Neighborhood Hits	49	Target Neighborhood Hits	355	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BFR2, Q80TG3, Q8C4T3	Gene names	Fstl5, Kiaa1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5) (m- D/Bsp120I 1-2).

CAN12_MOUSE
NC score	0.003987 (rank : 43)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	49	Target Neighborhood Hits	56	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ER56, Q9ER53, Q9ER54, Q9ER55	Gene names	Capn12
Domain Architecture
Description	Calpain-12 (EC 3.4.22.-).

PDE7A_HUMAN
NC score	0.003777 (rank : 44)	θ value	8.99809 (rank : 48)
Query Neighborhood Hits	49	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q13946, O15380	Gene names	PDE7A
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (HCP1) (TM22).

RXFP2_MOUSE
NC score	0.003418 (rank : 45)	θ value	6.88961 (rank : 41)
Query Neighborhood Hits	49	Target Neighborhood Hits	760	Shared Neighborhood Hits	4
SwissProt Accessions	Q91ZZ5	Gene names	Rxfp2, Gpr106, Great, Lgr8
Domain Architecture
Description	Relaxin receptor 2 (Relaxin family peptide receptor 2) (Leucine-rich repeat-containing G-protein coupled receptor 8) (G-protein coupled receptor affecting testicular descent) (G-protein coupled receptor 106).

ITSN1_MOUSE
NC score	0.002673 (rank : 46)	θ value	2.36792 (rank : 31)
Query Neighborhood Hits	49	Target Neighborhood Hits	1669	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

MAST1_HUMAN
NC score	0.001927 (rank : 47)	θ value	5.27518 (rank : 38)
Query Neighborhood Hits	49	Target Neighborhood Hits	1146	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

GLIS3_MOUSE
NC score	0.001681 (rank : 48)	θ value	1.38821 (rank : 23)
Query Neighborhood Hits	49	Target Neighborhood Hits	861	Shared Neighborhood Hits	3
SwissProt Accessions	Q6XP49, Q8BI60	Gene names	Glis3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS3 (GLI-similar 3).

STK6_HUMAN
NC score	-0.000911 (rank : 49)	θ value	4.03905 (rank : 36)
Query Neighborhood Hits	49	Target Neighborhood Hits	916	Shared Neighborhood Hits	4
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).