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Network neighborhood for query Sequence : MCCA_HUMAN

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MCCA_HUMAN
SwissProt Accessions	Q96RQ3, Q59ES4, Q9H959, Q9NS97	Gene names	MCCC1, MCCA
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MCCA_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	26	Target Neighborhood Hits	26	Shared Neighborhood Hits	26
SwissProt Accessions	Q96RQ3, Q59ES4, Q9H959, Q9NS97	Gene names	MCCC1, MCCA
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

MCCA_MOUSE
θ value	0 (rank : 2)	NC score	0.998357 (rank : 2)
Query Neighborhood Hits	26	Target Neighborhood Hits	18	Shared Neighborhood Hits	17
SwissProt Accessions	Q99MR8, Q3TGU0, Q9D8R2	Gene names	Mccc1, Mcca
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

PCCA_HUMAN
θ value	4.44261e-132 (rank : 3)	NC score	0.966541 (rank : 3)
Query Neighborhood Hits	26	Target Neighborhood Hits	22	Shared Neighborhood Hits	15
SwissProt Accessions	P05165, Q15979	Gene names	PCCA
Domain Architecture
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

PCCA_MOUSE
θ value	1.33764e-128 (rank : 4)	NC score	0.965229 (rank : 4)
Query Neighborhood Hits	26	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	Q91ZA3, Q80VU5, Q922N3	Gene names	Pcca
Domain Architecture	No domain graphic available
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

PYC_MOUSE
θ value	1.34698e-104 (rank : 5)	NC score	0.929228 (rank : 6)
Query Neighborhood Hits	26	Target Neighborhood Hits	25	Shared Neighborhood Hits	11
SwissProt Accessions	Q05920	Gene names	Pc, Pcx
Domain Architecture
Description	Pyruvate carboxylase, mitochondrial precursor (EC 6.4.1.1) (Pyruvic carboxylase) (PCB).

PYC_HUMAN
θ value	2.2976e-104 (rank : 6)	NC score	0.929332 (rank : 5)
Query Neighborhood Hits	26	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	P11498, Q16705	Gene names	PC
Domain Architecture
Description	Pyruvate carboxylase, mitochondrial precursor (EC 6.4.1.1) (Pyruvic carboxylase) (PCB).

COA1_HUMAN
θ value	6.55044e-59 (rank : 7)	NC score	0.821243 (rank : 7)
Query Neighborhood Hits	26	Target Neighborhood Hits	49	Shared Neighborhood Hits	13
SwissProt Accessions	Q13085	Gene names	ACACA, ACAC, ACC1, ACCA
Domain Architecture
Description	Acetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)].

COA2_HUMAN
θ value	1.51013e-55 (rank : 8)	NC score	0.785866 (rank : 8)
Query Neighborhood Hits	26	Target Neighborhood Hits	184	Shared Neighborhood Hits	11
SwissProt Accessions	O00763, Q16852	Gene names	ACACB, ACC2, ACCB
Domain Architecture
Description	Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) [Includes: Biotin carboxylase (EC 6.3.4.14)].

CPSM_MOUSE
θ value	1.47974e-10 (rank : 9)	NC score	0.414289 (rank : 9)
Query Neighborhood Hits	26	Target Neighborhood Hits	32	Shared Neighborhood Hits	13
SwissProt Accessions	Q8C196, Q6NX75	Gene names	Cps1
Domain Architecture	No domain graphic available
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

CPSM_HUMAN
θ value	1.25267e-09 (rank : 10)	NC score	0.407599 (rank : 10)
Query Neighborhood Hits	26	Target Neighborhood Hits	27	Shared Neighborhood Hits	13
SwissProt Accessions	P31327, O43774, Q7Z5I5	Gene names	CPS1
Domain Architecture
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

PYR1_HUMAN
θ value	1.99992e-07 (rank : 11)	NC score	0.391790 (rank : 11)
Query Neighborhood Hits	26	Target Neighborhood Hits	119	Shared Neighborhood Hits	13
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].

ODB2_HUMAN
θ value	0.00509761 (rank : 12)	NC score	0.124514 (rank : 12)
Query Neighborhood Hits	26	Target Neighborhood Hits	19	Shared Neighborhood Hits	8
SwissProt Accessions	P11182	Gene names	DBT, BCATE2
Domain Architecture
Description	Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor (EC 2.3.1.168) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) (E2) (Dihydrolipoamide branched chain transacylase) (BCKAD E2 subunit).

ODB2_MOUSE
θ value	0.0113563 (rank : 13)	NC score	0.118943 (rank : 13)
Query Neighborhood Hits	26	Target Neighborhood Hits	18	Shared Neighborhood Hits	8
SwissProt Accessions	P53395	Gene names	Dbt
Domain Architecture
Description	Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor (EC 2.3.1.168) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) (E2) (Dihydrolipoamide branched chain transacylase) (BCKAD E2 subunit).

ODPX_MOUSE
θ value	0.279714 (rank : 14)	NC score	0.090070 (rank : 14)
Query Neighborhood Hits	26	Target Neighborhood Hits	32	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BKZ9	Gene names	Pdhx
Domain Architecture	No domain graphic available
Description	Pyruvate dehydrogenase protein X component, mitochondrial precursor (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (Lipoyl-containing pyruvate dehydrogenase complex component X).

ODPX_HUMAN
θ value	0.47712 (rank : 15)	NC score	0.087384 (rank : 16)
Query Neighborhood Hits	26	Target Neighborhood Hits	24	Shared Neighborhood Hits	7
SwissProt Accessions	O00330, O60221, Q96FV8, Q99783	Gene names	PDHX, PDX1
Domain Architecture
Description	Pyruvate dehydrogenase protein X component, mitochondrial precursor (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (Lipoyl-containing pyruvate dehydrogenase complex component X) (E3-binding protein) (E3BP) (proX).

PUR2_HUMAN
θ value	0.813845 (rank : 16)	NC score	0.060409 (rank : 19)
Query Neighborhood Hits	26	Target Neighborhood Hits	21	Shared Neighborhood Hits	10
SwissProt Accessions	P22102	Gene names	GART, PRGS
Domain Architecture
Description	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)].

TITIN_HUMAN
θ value	1.38821 (rank : 17)	NC score	0.000789 (rank : 29)
Query Neighborhood Hits	26	Target Neighborhood Hits	2923	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

ANR12_HUMAN
θ value	3.0926 (rank : 18)	NC score	0.004191 (rank : 28)
Query Neighborhood Hits	26	Target Neighborhood Hits	1081	Shared Neighborhood Hits	4
SwissProt Accessions	Q6UB98, O94951, Q658K1, Q6QMF7, Q9H231, Q9H784	Gene names	ANKRD12, ANCO2, KIAA0874
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein).

SRY_MOUSE
θ value	4.03905 (rank : 19)	NC score	0.006357 (rank : 26)
Query Neighborhood Hits	26	Target Neighborhood Hits	139	Shared Neighborhood Hits	2
SwissProt Accessions	Q05738	Gene names	Sry, Tdf, Tdy
Domain Architecture
Description	Sex-determining region Y protein (Testis-determining factor).

IF3A_HUMAN
θ value	5.27518 (rank : 20)	NC score	0.007578 (rank : 24)
Query Neighborhood Hits	26	Target Neighborhood Hits	875	Shared Neighborhood Hits	5
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

IF3A_MOUSE
θ value	5.27518 (rank : 21)	NC score	0.007548 (rank : 25)
Query Neighborhood Hits	26	Target Neighborhood Hits	871	Shared Neighborhood Hits	4
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

ITF2_HUMAN
θ value	5.27518 (rank : 22)	NC score	0.012165 (rank : 22)
Query Neighborhood Hits	26	Target Neighborhood Hits	168	Shared Neighborhood Hits	4
SwissProt Accessions	P15884, Q15439, Q15440	Gene names	TCF4, ITF2, SEF2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2).

ITF2_MOUSE
θ value	6.88961 (rank : 23)	NC score	0.011464 (rank : 23)
Query Neighborhood Hits	26	Target Neighborhood Hits	154	Shared Neighborhood Hits	4
SwissProt Accessions	Q60722, Q60721, Q62211, Q64072, Q80UE8	Gene names	Tcf4, Itf2, Sef2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2).

ZN406_HUMAN
θ value	6.88961 (rank : 24)	NC score	-0.000971 (rank : 30)
Query Neighborhood Hits	26	Target Neighborhood Hits	794	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P243, Q3MIM5, Q6PJ01, Q75PJ7, Q75PJ9, Q86X64	Gene names	ZNF406, KIAA1485
Domain Architecture	No domain graphic available
Description	Zinc finger protein 406 (Protein ZFAT).

DMXL1_MOUSE
θ value	8.99809 (rank : 25)	NC score	0.005950 (rank : 27)
Query Neighborhood Hits	26	Target Neighborhood Hits	257	Shared Neighborhood Hits	5
SwissProt Accessions	Q6PNC0, Q3TLG8, Q6PHM6, Q8BQF2	Gene names	Dmxl1
Domain Architecture	No domain graphic available
Description	Protein DmX-like 1 (X-like 1 protein).

PUR2_MOUSE
θ value	8.99809 (rank : 26)	NC score	0.043002 (rank : 21)
Query Neighborhood Hits	26	Target Neighborhood Hits	18	Shared Neighborhood Hits	7
SwissProt Accessions	Q64737, Q6NS48	Gene names	Gart
Domain Architecture
Description	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)].

HMGCL_HUMAN
θ value	θ > 10 (rank : 27)	NC score	0.054558 (rank : 20)
Query Neighborhood Hits	26	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	P35914, Q96FP8	Gene names	HMGCL
Domain Architecture
Description	Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (EC 4.1.3.4) (HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase).

HMGCL_MOUSE
θ value	θ > 10 (rank : 28)	NC score	0.062424 (rank : 18)
Query Neighborhood Hits	26	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	P38060	Gene names	Hmgcl
Domain Architecture
Description	Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (EC 4.1.3.4) (HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase).

PCCB_HUMAN
θ value	θ > 10 (rank : 29)	NC score	0.086782 (rank : 17)
Query Neighborhood Hits	26	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	P05166, Q16813	Gene names	PCCB
Domain Architecture
Description	Propionyl-CoA carboxylase beta chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit beta) (Propanoyl-CoA:carbon dioxide ligase subunit beta).

PCCB_MOUSE
θ value	θ > 10 (rank : 30)	NC score	0.089358 (rank : 15)
Query Neighborhood Hits	26	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q99MN9	Gene names	Pccb
Domain Architecture	No domain graphic available
Description	Propionyl-CoA carboxylase beta chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit beta) (Propanoyl-CoA:carbon dioxide ligase subunit beta).

Hits sorted by NC score

MCCA_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	26	Target Neighborhood Hits	26	Shared Neighborhood Hits	26
SwissProt Accessions	Q96RQ3, Q59ES4, Q9H959, Q9NS97	Gene names	MCCC1, MCCA
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

MCCA_MOUSE
NC score	0.998357 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	26	Target Neighborhood Hits	18	Shared Neighborhood Hits	17
SwissProt Accessions	Q99MR8, Q3TGU0, Q9D8R2	Gene names	Mccc1, Mcca
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

PCCA_HUMAN
NC score	0.966541 (rank : 3)	θ value	4.44261e-132 (rank : 3)
Query Neighborhood Hits	26	Target Neighborhood Hits	22	Shared Neighborhood Hits	15
SwissProt Accessions	P05165, Q15979	Gene names	PCCA
Domain Architecture
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

PCCA_MOUSE
NC score	0.965229 (rank : 4)	θ value	1.33764e-128 (rank : 4)
Query Neighborhood Hits	26	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	Q91ZA3, Q80VU5, Q922N3	Gene names	Pcca
Domain Architecture	No domain graphic available
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

PYC_HUMAN
NC score	0.929332 (rank : 5)	θ value	2.2976e-104 (rank : 6)
Query Neighborhood Hits	26	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	P11498, Q16705	Gene names	PC
Domain Architecture
Description	Pyruvate carboxylase, mitochondrial precursor (EC 6.4.1.1) (Pyruvic carboxylase) (PCB).

PYC_MOUSE
NC score	0.929228 (rank : 6)	θ value	1.34698e-104 (rank : 5)
Query Neighborhood Hits	26	Target Neighborhood Hits	25	Shared Neighborhood Hits	11
SwissProt Accessions	Q05920	Gene names	Pc, Pcx
Domain Architecture
Description	Pyruvate carboxylase, mitochondrial precursor (EC 6.4.1.1) (Pyruvic carboxylase) (PCB).

COA1_HUMAN
NC score	0.821243 (rank : 7)	θ value	6.55044e-59 (rank : 7)
Query Neighborhood Hits	26	Target Neighborhood Hits	49	Shared Neighborhood Hits	13
SwissProt Accessions	Q13085	Gene names	ACACA, ACAC, ACC1, ACCA
Domain Architecture
Description	Acetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)].

COA2_HUMAN
NC score	0.785866 (rank : 8)	θ value	1.51013e-55 (rank : 8)
Query Neighborhood Hits	26	Target Neighborhood Hits	184	Shared Neighborhood Hits	11
SwissProt Accessions	O00763, Q16852	Gene names	ACACB, ACC2, ACCB
Domain Architecture
Description	Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) [Includes: Biotin carboxylase (EC 6.3.4.14)].

CPSM_MOUSE
NC score	0.414289 (rank : 9)	θ value	1.47974e-10 (rank : 9)
Query Neighborhood Hits	26	Target Neighborhood Hits	32	Shared Neighborhood Hits	13
SwissProt Accessions	Q8C196, Q6NX75	Gene names	Cps1
Domain Architecture	No domain graphic available
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

CPSM_HUMAN
NC score	0.407599 (rank : 10)	θ value	1.25267e-09 (rank : 10)
Query Neighborhood Hits	26	Target Neighborhood Hits	27	Shared Neighborhood Hits	13
SwissProt Accessions	P31327, O43774, Q7Z5I5	Gene names	CPS1
Domain Architecture
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

PYR1_HUMAN
NC score	0.391790 (rank : 11)	θ value	1.99992e-07 (rank : 11)
Query Neighborhood Hits	26	Target Neighborhood Hits	119	Shared Neighborhood Hits	13
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].

ODB2_HUMAN
NC score	0.124514 (rank : 12)	θ value	0.00509761 (rank : 12)
Query Neighborhood Hits	26	Target Neighborhood Hits	19	Shared Neighborhood Hits	8
SwissProt Accessions	P11182	Gene names	DBT, BCATE2
Domain Architecture
Description	Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor (EC 2.3.1.168) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) (E2) (Dihydrolipoamide branched chain transacylase) (BCKAD E2 subunit).

ODB2_MOUSE
NC score	0.118943 (rank : 13)	θ value	0.0113563 (rank : 13)
Query Neighborhood Hits	26	Target Neighborhood Hits	18	Shared Neighborhood Hits	8
SwissProt Accessions	P53395	Gene names	Dbt
Domain Architecture
Description	Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor (EC 2.3.1.168) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) (E2) (Dihydrolipoamide branched chain transacylase) (BCKAD E2 subunit).

ODPX_MOUSE
NC score	0.090070 (rank : 14)	θ value	0.279714 (rank : 14)
Query Neighborhood Hits	26	Target Neighborhood Hits	32	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BKZ9	Gene names	Pdhx
Domain Architecture	No domain graphic available
Description	Pyruvate dehydrogenase protein X component, mitochondrial precursor (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (Lipoyl-containing pyruvate dehydrogenase complex component X).

PCCB_MOUSE
NC score	0.089358 (rank : 15)	θ value	θ > 10 (rank : 30)
Query Neighborhood Hits	26	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q99MN9	Gene names	Pccb
Domain Architecture	No domain graphic available
Description	Propionyl-CoA carboxylase beta chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit beta) (Propanoyl-CoA:carbon dioxide ligase subunit beta).

ODPX_HUMAN
NC score	0.087384 (rank : 16)	θ value	0.47712 (rank : 15)
Query Neighborhood Hits	26	Target Neighborhood Hits	24	Shared Neighborhood Hits	7
SwissProt Accessions	O00330, O60221, Q96FV8, Q99783	Gene names	PDHX, PDX1
Domain Architecture
Description	Pyruvate dehydrogenase protein X component, mitochondrial precursor (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (Lipoyl-containing pyruvate dehydrogenase complex component X) (E3-binding protein) (E3BP) (proX).

PCCB_HUMAN
NC score	0.086782 (rank : 17)	θ value	θ > 10 (rank : 29)
Query Neighborhood Hits	26	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	P05166, Q16813	Gene names	PCCB
Domain Architecture
Description	Propionyl-CoA carboxylase beta chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit beta) (Propanoyl-CoA:carbon dioxide ligase subunit beta).

HMGCL_MOUSE
NC score	0.062424 (rank : 18)	θ value	θ > 10 (rank : 28)
Query Neighborhood Hits	26	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	P38060	Gene names	Hmgcl
Domain Architecture
Description	Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (EC 4.1.3.4) (HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase).

PUR2_HUMAN
NC score	0.060409 (rank : 19)	θ value	0.813845 (rank : 16)
Query Neighborhood Hits	26	Target Neighborhood Hits	21	Shared Neighborhood Hits	10
SwissProt Accessions	P22102	Gene names	GART, PRGS
Domain Architecture
Description	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)].

HMGCL_HUMAN
NC score	0.054558 (rank : 20)	θ value	θ > 10 (rank : 27)
Query Neighborhood Hits	26	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	P35914, Q96FP8	Gene names	HMGCL
Domain Architecture
Description	Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (EC 4.1.3.4) (HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase).

PUR2_MOUSE
NC score	0.043002 (rank : 21)	θ value	8.99809 (rank : 26)
Query Neighborhood Hits	26	Target Neighborhood Hits	18	Shared Neighborhood Hits	7
SwissProt Accessions	Q64737, Q6NS48	Gene names	Gart
Domain Architecture
Description	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)].

ITF2_HUMAN
NC score	0.012165 (rank : 22)	θ value	5.27518 (rank : 22)
Query Neighborhood Hits	26	Target Neighborhood Hits	168	Shared Neighborhood Hits	4
SwissProt Accessions	P15884, Q15439, Q15440	Gene names	TCF4, ITF2, SEF2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2).

ITF2_MOUSE
NC score	0.011464 (rank : 23)	θ value	6.88961 (rank : 23)
Query Neighborhood Hits	26	Target Neighborhood Hits	154	Shared Neighborhood Hits	4
SwissProt Accessions	Q60722, Q60721, Q62211, Q64072, Q80UE8	Gene names	Tcf4, Itf2, Sef2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2).

IF3A_HUMAN
NC score	0.007578 (rank : 24)	θ value	5.27518 (rank : 20)
Query Neighborhood Hits	26	Target Neighborhood Hits	875	Shared Neighborhood Hits	5
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

IF3A_MOUSE
NC score	0.007548 (rank : 25)	θ value	5.27518 (rank : 21)
Query Neighborhood Hits	26	Target Neighborhood Hits	871	Shared Neighborhood Hits	4
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

SRY_MOUSE
NC score	0.006357 (rank : 26)	θ value	4.03905 (rank : 19)
Query Neighborhood Hits	26	Target Neighborhood Hits	139	Shared Neighborhood Hits	2
SwissProt Accessions	Q05738	Gene names	Sry, Tdf, Tdy
Domain Architecture
Description	Sex-determining region Y protein (Testis-determining factor).

DMXL1_MOUSE
NC score	0.005950 (rank : 27)	θ value	8.99809 (rank : 25)
Query Neighborhood Hits	26	Target Neighborhood Hits	257	Shared Neighborhood Hits	5
SwissProt Accessions	Q6PNC0, Q3TLG8, Q6PHM6, Q8BQF2	Gene names	Dmxl1
Domain Architecture	No domain graphic available
Description	Protein DmX-like 1 (X-like 1 protein).

ANR12_HUMAN
NC score	0.004191 (rank : 28)	θ value	3.0926 (rank : 18)
Query Neighborhood Hits	26	Target Neighborhood Hits	1081	Shared Neighborhood Hits	4
SwissProt Accessions	Q6UB98, O94951, Q658K1, Q6QMF7, Q9H231, Q9H784	Gene names	ANKRD12, ANCO2, KIAA0874
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein).

TITIN_HUMAN
NC score	0.000789 (rank : 29)	θ value	1.38821 (rank : 17)
Query Neighborhood Hits	26	Target Neighborhood Hits	2923	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

ZN406_HUMAN
NC score	-0.000971 (rank : 30)	θ value	6.88961 (rank : 24)
Query Neighborhood Hits	26	Target Neighborhood Hits	794	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P243, Q3MIM5, Q6PJ01, Q75PJ7, Q75PJ9, Q86X64	Gene names	ZNF406, KIAA1485
Domain Architecture	No domain graphic available
Description	Zinc finger protein 406 (Protein ZFAT).