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Network neighborhood for query Sequence : PYR1_HUMAN

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PYR1_HUMAN
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CPSM_HUMAN
θ value	0 (rank : 1)	NC score	0.918234 (rank : 2)
Query Neighborhood Hits	119	Target Neighborhood Hits	27	Shared Neighborhood Hits	13
SwissProt Accessions	P31327, O43774, Q7Z5I5	Gene names	CPS1
Domain Architecture
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

CPSM_MOUSE
θ value	0 (rank : 2)	NC score	0.917954 (rank : 3)
Query Neighborhood Hits	119	Target Neighborhood Hits	32	Shared Neighborhood Hits	13
SwissProt Accessions	Q8C196, Q6NX75	Gene names	Cps1
Domain Architecture	No domain graphic available
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

PYR1_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	119	Target Neighborhood Hits	119	Shared Neighborhood Hits	119
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].

OTC_MOUSE
θ value	2.06002e-20 (rank : 4)	NC score	0.364949 (rank : 11)
Query Neighborhood Hits	119	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	P11725	Gene names	Otc
Domain Architecture
Description	Ornithine carbamoyltransferase, mitochondrial precursor (EC 2.1.3.3) (OTCase) (Ornithine transcarbamylase).

OTC_HUMAN
θ value	1.33526e-19 (rank : 5)	NC score	0.360353 (rank : 12)
Query Neighborhood Hits	119	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	P00480, Q6B0I1, Q9NYJ5	Gene names	OTC
Domain Architecture
Description	Ornithine carbamoyltransferase, mitochondrial precursor (EC 2.1.3.3) (OTCase) (Ornithine transcarbamylase).

PYC_MOUSE
θ value	1.2105e-12 (rank : 6)	NC score	0.408544 (rank : 4)
Query Neighborhood Hits	119	Target Neighborhood Hits	25	Shared Neighborhood Hits	11
SwissProt Accessions	Q05920	Gene names	Pc, Pcx
Domain Architecture
Description	Pyruvate carboxylase, mitochondrial precursor (EC 6.4.1.1) (Pyruvic carboxylase) (PCB).

PYC_HUMAN
θ value	4.59992e-12 (rank : 7)	NC score	0.403585 (rank : 5)
Query Neighborhood Hits	119	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	P11498, Q16705	Gene names	PC
Domain Architecture
Description	Pyruvate carboxylase, mitochondrial precursor (EC 6.4.1.1) (Pyruvic carboxylase) (PCB).

COA1_HUMAN
θ value	7.84624e-12 (rank : 8)	NC score	0.396358 (rank : 6)
Query Neighborhood Hits	119	Target Neighborhood Hits	49	Shared Neighborhood Hits	13
SwissProt Accessions	Q13085	Gene names	ACACA, ACAC, ACC1, ACCA
Domain Architecture
Description	Acetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)].

COA2_HUMAN
θ value	7.34386e-10 (rank : 9)	NC score	0.351412 (rank : 13)
Query Neighborhood Hits	119	Target Neighborhood Hits	184	Shared Neighborhood Hits	12
SwissProt Accessions	O00763, Q16852	Gene names	ACACB, ACC2, ACCB
Domain Architecture
Description	Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) [Includes: Biotin carboxylase (EC 6.3.4.14)].

PCCA_HUMAN
θ value	9.59137e-10 (rank : 10)	NC score	0.392575 (rank : 8)
Query Neighborhood Hits	119	Target Neighborhood Hits	22	Shared Neighborhood Hits	12
SwissProt Accessions	P05165, Q15979	Gene names	PCCA
Domain Architecture
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

PCCA_MOUSE
θ value	1.63604e-09 (rank : 11)	NC score	0.393927 (rank : 7)
Query Neighborhood Hits	119	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	Q91ZA3, Q80VU5, Q922N3	Gene names	Pcca
Domain Architecture	No domain graphic available
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

DPYL4_MOUSE
θ value	1.80886e-08 (rank : 12)	NC score	0.259396 (rank : 14)
Query Neighborhood Hits	119	Target Neighborhood Hits	21	Shared Neighborhood Hits	13
SwissProt Accessions	O35098, O08886	Gene names	Dpysl4, Crmp3, Ulip4
Domain Architecture
Description	Dihydropyrimidinase-related protein 4 (DRP-4) (Collapsin response mediator protein 3) (CRMP-3) (UNC33-like phosphoprotein 4) (ULIP4 protein).

MCCA_HUMAN
θ value	1.99992e-07 (rank : 13)	NC score	0.391790 (rank : 9)
Query Neighborhood Hits	119	Target Neighborhood Hits	26	Shared Neighborhood Hits	13
SwissProt Accessions	Q96RQ3, Q59ES4, Q9H959, Q9NS97	Gene names	MCCC1, MCCA
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

DPYL4_HUMAN
θ value	2.61198e-07 (rank : 14)	NC score	0.255802 (rank : 15)
Query Neighborhood Hits	119	Target Neighborhood Hits	25	Shared Neighborhood Hits	13
SwissProt Accessions	O14531, O00240, Q5T0Q7	Gene names	DPYSL4, CRMP3, ULIP4
Domain Architecture
Description	Dihydropyrimidinase-related protein 4 (DRP-4) (Collapsin response mediator protein 3) (CRMP-3) (UNC33-like phosphoprotein 4) (ULIP4 protein).

DPYL5_MOUSE
θ value	2.88788e-06 (rank : 15)	NC score	0.253278 (rank : 16)
Query Neighborhood Hits	119	Target Neighborhood Hits	18	Shared Neighborhood Hits	13
SwissProt Accessions	Q9EQF6	Gene names	Dpysl5, Crmp5
Domain Architecture
Description	Dihydropyrimidinase-related protein 5 (DRP-5) (Collapsin response mediator protein 5) (CRMP-5).

DPYL3_HUMAN
θ value	3.19293e-05 (rank : 16)	NC score	0.247706 (rank : 19)
Query Neighborhood Hits	119	Target Neighborhood Hits	20	Shared Neighborhood Hits	13
SwissProt Accessions	Q14195, Q93012	Gene names	DPYSL3, CRMP4, DRP3, ULIP
Domain Architecture
Description	Dihydropyrimidinase-related protein 3 (DRP-3) (Unc-33-like phosphoprotein) (ULIP protein) (Collapsin response mediator protein 4) (CRMP-4).

DPYL3_MOUSE
θ value	3.19293e-05 (rank : 17)	NC score	0.247768 (rank : 18)
Query Neighborhood Hits	119	Target Neighborhood Hits	19	Shared Neighborhood Hits	13
SwissProt Accessions	Q62188	Gene names	Dpysl3, Drp3, Ulip
Domain Architecture
Description	Dihydropyrimidinase-related protein 3 (DRP-3) (Unc-33-like phosphoprotein) (ULIP protein).

DPYL5_HUMAN
θ value	7.1131e-05 (rank : 18)	NC score	0.248148 (rank : 17)
Query Neighborhood Hits	119	Target Neighborhood Hits	20	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BPU6, Q8TCL6, Q9NQC4, Q9NRY9	Gene names	DPYSL5, CRMP5, ULIP6
Domain Architecture
Description	Dihydropyrimidinase-related protein 5 (DRP-5) (ULIP6 protein) (Collapsin response mediator protein 5) (CRMP-5) (CRMP3-associated molecule) (CRAM).

DPYS_MOUSE
θ value	9.29e-05 (rank : 19)	NC score	0.246805 (rank : 20)
Query Neighborhood Hits	119	Target Neighborhood Hits	18	Shared Neighborhood Hits	13
SwissProt Accessions	Q9EQF5, Q99PP1, Q9DBK3, Q9DBP7	Gene names	Dpys
Domain Architecture
Description	Dihydropyrimidinase (EC 3.5.2.2) (DHPase) (Hydantoinase) (DHP).

DPYL2_HUMAN
θ value	0.000121331 (rank : 20)	NC score	0.245323 (rank : 21)
Query Neighborhood Hits	119	Target Neighborhood Hits	19	Shared Neighborhood Hits	13
SwissProt Accessions	Q16555, O00424	Gene names	DPYSL2, CRMP2
Domain Architecture
Description	Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3).

DPYL2_MOUSE
θ value	0.000270298 (rank : 21)	NC score	0.244051 (rank : 23)
Query Neighborhood Hits	119	Target Neighborhood Hits	21	Shared Neighborhood Hits	13
SwissProt Accessions	O08553, Q6P5D0	Gene names	Dpysl2, Crmp2, Ulip2
Domain Architecture	No domain graphic available
Description	Dihydropyrimidinase-related protein 2 (DRP-2) (ULIP 2 protein).

DPYL1_MOUSE
θ value	0.00035302 (rank : 22)	NC score	0.243651 (rank : 24)
Query Neighborhood Hits	119	Target Neighborhood Hits	17	Shared Neighborhood Hits	13
SwissProt Accessions	P97427, O08554, O35097	Gene names	Crmp1, Dpysl1, Ulip3
Domain Architecture
Description	Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (ULIP3 protein).

DPYS_HUMAN
θ value	0.00035302 (rank : 23)	NC score	0.244718 (rank : 22)
Query Neighborhood Hits	119	Target Neighborhood Hits	17	Shared Neighborhood Hits	13
SwissProt Accessions	Q14117	Gene names	DPYS
Domain Architecture
Description	Dihydropyrimidinase (EC 3.5.2.2) (DHPase) (Hydantoinase) (DHP).

MCCA_MOUSE
θ value	0.00035302 (rank : 24)	NC score	0.367421 (rank : 10)
Query Neighborhood Hits	119	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	Q99MR8, Q3TGU0, Q9D8R2	Gene names	Mccc1, Mcca
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

DPYL1_HUMAN
θ value	0.00134147 (rank : 25)	NC score	0.241371 (rank : 25)
Query Neighborhood Hits	119	Target Neighborhood Hits	16	Shared Neighborhood Hits	13
SwissProt Accessions	Q14194, Q13024, Q96TC8	Gene names	CRMP1, DPYSL1
Domain Architecture
Description	Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1).

ATX7_HUMAN
θ value	0.00869519 (rank : 26)	NC score	0.067833 (rank : 29)
Query Neighborhood Hits	119	Target Neighborhood Hits	351	Shared Neighborhood Hits	26
SwissProt Accessions	O15265, O75328, O75329, Q9Y6P8	Gene names	ATXN7, SCA7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein).

EGF_MOUSE
θ value	0.0148317 (rank : 27)	NC score	0.022308 (rank : 52)
Query Neighborhood Hits	119	Target Neighborhood Hits	358	Shared Neighborhood Hits	4
SwissProt Accessions	P01132, Q6P9J2	Gene names	Egf
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor].

ACK1_HUMAN
θ value	0.0563607 (rank : 28)	NC score	0.009828 (rank : 93)
Query Neighborhood Hits	119	Target Neighborhood Hits	1140	Shared Neighborhood Hits	21
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ADA2B_MOUSE
θ value	0.0563607 (rank : 29)	NC score	0.007540 (rank : 101)
Query Neighborhood Hits	119	Target Neighborhood Hits	891	Shared Neighborhood Hits	2
SwissProt Accessions	P30545	Gene names	Adra2b
Domain Architecture
Description	Alpha-2B adrenergic receptor (Alpha-2B adrenoceptor) (Alpha-2B adrenoreceptor).

GUAA_HUMAN
θ value	0.0961366 (rank : 30)	NC score	0.142600 (rank : 26)
Query Neighborhood Hits	119	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	P49915	Gene names	GMPS
Domain Architecture
Description	GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (Glutamine amidotransferase) (GMP synthetase).

HCN2_HUMAN
θ value	0.163984 (rank : 31)	NC score	0.023808 (rank : 48)
Query Neighborhood Hits	119	Target Neighborhood Hits	369	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

PUR2_HUMAN
θ value	0.163984 (rank : 32)	NC score	0.085450 (rank : 27)
Query Neighborhood Hits	119	Target Neighborhood Hits	21	Shared Neighborhood Hits	9
SwissProt Accessions	P22102	Gene names	GART, PRGS
Domain Architecture
Description	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)].

LCP2_MOUSE
θ value	0.21417 (rank : 33)	NC score	0.049573 (rank : 30)
Query Neighborhood Hits	119	Target Neighborhood Hits	177	Shared Neighborhood Hits	7
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

RTN4_MOUSE
θ value	0.21417 (rank : 34)	NC score	0.030014 (rank : 39)
Query Neighborhood Hits	119	Target Neighborhood Hits	341	Shared Neighborhood Hits	10
SwissProt Accessions	Q99P72, Q5DTK9, Q7TNB7, Q80W95, Q8BGK7, Q8BGM9, Q8K290, Q8K3G8, Q9CTE3	Gene names	Rtn4, Kiaa0886, Nogo
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein).

ZN541_HUMAN
θ value	0.21417 (rank : 35)	NC score	0.041053 (rank : 32)
Query Neighborhood Hits	119	Target Neighborhood Hits	203	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H0D2, Q8NDK8	Gene names	ZNF541
Domain Architecture	No domain graphic available
Description	Zinc finger protein 541.

NGN1_HUMAN
θ value	0.279714 (rank : 36)	NC score	0.026204 (rank : 43)
Query Neighborhood Hits	119	Target Neighborhood Hits	83	Shared Neighborhood Hits	2
SwissProt Accessions	Q92886, Q96HE1	Gene names	NEUROG1, NEUROD3, NGN, NGN1
Domain Architecture
Description	Neurogenin 1 (Neurogenic differentiation factor 3) (NeuroD3) (Neurogenic basic-helix-loop-helix protein).

ADDA_MOUSE
θ value	0.365318 (rank : 37)	NC score	0.025292 (rank : 45)
Query Neighborhood Hits	119	Target Neighborhood Hits	198	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QYC0, Q9JLE3	Gene names	Add1
Domain Architecture
Description	Alpha-adducin (Erythrocyte adducin subunit alpha).

AT1A4_MOUSE
θ value	0.62314 (rank : 38)	NC score	0.014228 (rank : 75)
Query Neighborhood Hits	119	Target Neighborhood Hits	63	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WV27, Q9R173, Q9WV28	Gene names	Atp1a4, Atp1al2
Domain Architecture
Description	Sodium/potassium-transporting ATPase alpha-4 chain (EC 3.6.3.9) (Sodium pump 4) (Na+/K+ ATPase 4).

CS021_MOUSE
θ value	0.813845 (rank : 39)	NC score	0.034481 (rank : 36)
Query Neighborhood Hits	119	Target Neighborhood Hits	47	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D279, Q3UI04	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf21 homolog.

GNAS1_HUMAN
θ value	0.813845 (rank : 40)	NC score	0.012159 (rank : 81)
Query Neighborhood Hits	119	Target Neighborhood Hits	278	Shared Neighborhood Hits	13
SwissProt Accessions	Q5JWF2, O75684, O75685, Q5JW67, Q5JWF1, Q9NY42	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

WASL_HUMAN
θ value	0.813845 (rank : 41)	NC score	0.036365 (rank : 35)
Query Neighborhood Hits	119	Target Neighborhood Hits	312	Shared Neighborhood Hits	15
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

LAMA5_MOUSE
θ value	1.06291 (rank : 42)	NC score	0.008085 (rank : 99)
Query Neighborhood Hits	119	Target Neighborhood Hits	828	Shared Neighborhood Hits	11
SwissProt Accessions	Q61001, Q9JHQ6	Gene names	Lama5
Domain Architecture
Description	Laminin alpha-5 chain precursor.

LCP2_HUMAN
θ value	1.06291 (rank : 43)	NC score	0.043103 (rank : 31)
Query Neighborhood Hits	119	Target Neighborhood Hits	531	Shared Neighborhood Hits	28
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

SRBS1_HUMAN
θ value	1.06291 (rank : 44)	NC score	0.018415 (rank : 61)
Query Neighborhood Hits	119	Target Neighborhood Hits	396	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

TNK1_HUMAN
θ value	1.06291 (rank : 45)	NC score	0.006967 (rank : 104)
Query Neighborhood Hits	119	Target Neighborhood Hits	815	Shared Neighborhood Hits	8
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

WBP11_HUMAN
θ value	1.06291 (rank : 46)	NC score	0.039557 (rank : 34)
Query Neighborhood Hits	119	Target Neighborhood Hits	354	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

WBP11_MOUSE
θ value	1.06291 (rank : 47)	NC score	0.039717 (rank : 33)
Query Neighborhood Hits	119	Target Neighborhood Hits	362	Shared Neighborhood Hits	13
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

FOXI2_MOUSE
θ value	1.38821 (rank : 48)	NC score	0.008929 (rank : 96)
Query Neighborhood Hits	119	Target Neighborhood Hits	89	Shared Neighborhood Hits	2
SwissProt Accessions	Q3I5G5, Q8BIK9	Gene names	Foxi2
Domain Architecture	No domain graphic available
Description	Forkhead box protein I2.

HXA4_MOUSE
θ value	1.38821 (rank : 49)	NC score	0.005481 (rank : 109)
Query Neighborhood Hits	119	Target Neighborhood Hits	379	Shared Neighborhood Hits	4
SwissProt Accessions	P06798, Q61684, Q64388, Q8BPE6	Gene names	Hoxa4, Hox-1.4, Hoxa-4
Domain Architecture
Description	Homeobox protein Hox-A4 (Hox-1.4) (Homeobox protein MH-3).

NCOA6_HUMAN
θ value	1.38821 (rank : 50)	NC score	0.028333 (rank : 41)
Query Neighborhood Hits	119	Target Neighborhood Hits	1202	Shared Neighborhood Hits	46
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

DYN2_HUMAN
θ value	1.81305 (rank : 51)	NC score	0.014987 (rank : 70)
Query Neighborhood Hits	119	Target Neighborhood Hits	112	Shared Neighborhood Hits	8
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

INGR1_HUMAN
θ value	1.81305 (rank : 52)	NC score	0.027946 (rank : 42)
Query Neighborhood Hits	119	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	P15260	Gene names	IFNGR1
Domain Architecture
Description	Interferon-gamma receptor alpha chain precursor (IFN-gamma-R1) (CD119 antigen) (CDw119).

M3K1_MOUSE
θ value	1.81305 (rank : 53)	NC score	0.002146 (rank : 115)
Query Neighborhood Hits	119	Target Neighborhood Hits	952	Shared Neighborhood Hits	9
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

NETR_HUMAN
θ value	1.81305 (rank : 54)	NC score	0.004045 (rank : 113)
Query Neighborhood Hits	119	Target Neighborhood Hits	218	Shared Neighborhood Hits	3
SwissProt Accessions	P56730, Q9UP16	Gene names	PRSS12
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Leydin).

SEM6C_MOUSE
θ value	1.81305 (rank : 55)	NC score	0.012281 (rank : 80)
Query Neighborhood Hits	119	Target Neighborhood Hits	352	Shared Neighborhood Hits	28
SwissProt Accessions	Q9WTM3	Gene names	Sema6c, Semay
Domain Architecture
Description	Semaphorin-6C precursor (Semaphorin Y) (Sema Y).

BRD4_HUMAN
θ value	2.36792 (rank : 56)	NC score	0.019942 (rank : 57)
Query Neighborhood Hits	119	Target Neighborhood Hits	851	Shared Neighborhood Hits	16
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

BRD4_MOUSE
θ value	2.36792 (rank : 57)	NC score	0.019901 (rank : 58)
Query Neighborhood Hits	119	Target Neighborhood Hits	845	Shared Neighborhood Hits	18
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

CAC1A_HUMAN
θ value	2.36792 (rank : 58)	NC score	0.009319 (rank : 94)
Query Neighborhood Hits	119	Target Neighborhood Hits	387	Shared Neighborhood Hits	18
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CBP_HUMAN
θ value	2.36792 (rank : 59)	NC score	0.023951 (rank : 47)
Query Neighborhood Hits	119	Target Neighborhood Hits	941	Shared Neighborhood Hits	27
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CO4A5_HUMAN
θ value	2.36792 (rank : 60)	NC score	0.014967 (rank : 71)
Query Neighborhood Hits	119	Target Neighborhood Hits	383	Shared Neighborhood Hits	16
SwissProt Accessions	P29400, Q16006, Q16126, Q6LD84	Gene names	COL4A5
Domain Architecture
Description	Collagen alpha-5(IV) chain precursor.

SAPS1_HUMAN
θ value	2.36792 (rank : 61)	NC score	0.020328 (rank : 56)
Query Neighborhood Hits	119	Target Neighborhood Hits	704	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

SRRM1_MOUSE
θ value	2.36792 (rank : 62)	NC score	0.022350 (rank : 51)
Query Neighborhood Hits	119	Target Neighborhood Hits	966	Shared Neighborhood Hits	32
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

TAF1C_HUMAN
θ value	2.36792 (rank : 63)	NC score	0.023983 (rank : 46)
Query Neighborhood Hits	119	Target Neighborhood Hits	36	Shared Neighborhood Hits	3
SwissProt Accessions	Q15572, Q59F67, Q8N6V3	Gene names	TAF1C
Domain Architecture	No domain graphic available
Description	TATA box-binding protein-associated factor RNA polymerase I subunit C (TATA box-binding protein-associated factor 1C) (TBP-associated factor 1C) (TBP-associated factor RNA polymerase I 110 kDa) (TAFI110).

WASL_MOUSE
θ value	2.36792 (rank : 64)	NC score	0.031478 (rank : 38)
Query Neighborhood Hits	119	Target Neighborhood Hits	339	Shared Neighborhood Hits	14
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

AT1A4_HUMAN
θ value	3.0926 (rank : 65)	NC score	0.011460 (rank : 87)
Query Neighborhood Hits	119	Target Neighborhood Hits	67	Shared Neighborhood Hits	4
SwissProt Accessions	Q13733, Q504T2, Q8TBN8, Q8WXA7, Q8WXH7, Q8WY13	Gene names	ATP1A4, ATP1AL2
Domain Architecture
Description	Sodium/potassium-transporting ATPase alpha-4 chain (EC 3.6.3.9) (Sodium pump 4) (Na+/K+ ATPase 4).

BRWD1_MOUSE
θ value	3.0926 (rank : 66)	NC score	0.011607 (rank : 86)
Query Neighborhood Hits	119	Target Neighborhood Hits	478	Shared Neighborhood Hits	13
SwissProt Accessions	Q921C3, Q921C2	Gene names	Brwd1, Wdr9
Domain Architecture	No domain graphic available
Description	Bromodomain and WD repeat domain-containing protein 1 (WD repeat protein 9).

HIC1_MOUSE
θ value	3.0926 (rank : 67)	NC score	0.000446 (rank : 117)
Query Neighborhood Hits	119	Target Neighborhood Hits	863	Shared Neighborhood Hits	7
SwissProt Accessions	Q9R1Y5, Q9R1Y6, Q9R2B0	Gene names	Hic1
Domain Architecture
Description	Hypermethylated in cancer 1 protein (Hic-1).

MADCA_HUMAN
θ value	3.0926 (rank : 68)	NC score	0.023334 (rank : 49)
Query Neighborhood Hits	119	Target Neighborhood Hits	221	Shared Neighborhood Hits	9
SwissProt Accessions	Q13477, O60222, O75867	Gene names	MADCAM1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (hMAdCAM-1).

PRCC_HUMAN
θ value	3.0926 (rank : 69)	NC score	0.031795 (rank : 37)
Query Neighborhood Hits	119	Target Neighborhood Hits	109	Shared Neighborhood Hits	6
SwissProt Accessions	Q92733, O00665, O00724	Gene names	PRCC, TPRC
Domain Architecture	No domain graphic available
Description	Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein).

STRN3_MOUSE
θ value	3.0926 (rank : 70)	NC score	0.012702 (rank : 79)
Query Neighborhood Hits	119	Target Neighborhood Hits	309	Shared Neighborhood Hits	6
SwissProt Accessions	Q9ERG2	Gene names	Strn3, Gs2na, Sg2na
Domain Architecture
Description	Striatin-3 (Cell-cycle autoantigen SG2NA) (S/G2 antigen).

YLPM1_MOUSE
θ value	3.0926 (rank : 71)	NC score	0.021082 (rank : 55)
Query Neighborhood Hits	119	Target Neighborhood Hits	505	Shared Neighborhood Hits	14
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

CBP_MOUSE
θ value	4.03905 (rank : 72)	NC score	0.022124 (rank : 53)
Query Neighborhood Hits	119	Target Neighborhood Hits	1051	Shared Neighborhood Hits	32
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

DDEF2_HUMAN
θ value	4.03905 (rank : 73)	NC score	0.006171 (rank : 108)
Query Neighborhood Hits	119	Target Neighborhood Hits	599	Shared Neighborhood Hits	5
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

FAK1_MOUSE
θ value	4.03905 (rank : 74)	NC score	0.002603 (rank : 114)
Query Neighborhood Hits	119	Target Neighborhood Hits	850	Shared Neighborhood Hits	7
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FMN2_HUMAN
θ value	4.03905 (rank : 75)	NC score	0.015939 (rank : 67)
Query Neighborhood Hits	119	Target Neighborhood Hits	484	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

HIC1_HUMAN
θ value	4.03905 (rank : 76)	NC score	0.000107 (rank : 118)
Query Neighborhood Hits	119	Target Neighborhood Hits	838	Shared Neighborhood Hits	7
SwissProt Accessions	Q14526	Gene names	HIC1, ZBTB29
Domain Architecture
Description	Hypermethylated in cancer 1 protein (Hic-1) (Zinc finger and BTB domain-containing protein 29).

PCX3_MOUSE
θ value	4.03905 (rank : 77)	NC score	0.017741 (rank : 64)
Query Neighborhood Hits	119	Target Neighborhood Hits	134	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VI59	Gene names	Pcnxl3
Domain Architecture
Description	Pecanex-like protein 3.

SON_HUMAN
θ value	4.03905 (rank : 78)	NC score	0.021465 (rank : 54)
Query Neighborhood Hits	119	Target Neighborhood Hits	1568	Shared Neighborhood Hits	55
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

UBP36_HUMAN
θ value	4.03905 (rank : 79)	NC score	0.008790 (rank : 98)
Query Neighborhood Hits	119	Target Neighborhood Hits	232	Shared Neighborhood Hits	7
SwissProt Accessions	Q9P275, Q8NDM8, Q9NVC8	Gene names	USP36, KIAA1453
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.1.2.15) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) (Deubiquitinating enzyme 36).

BAI1_HUMAN
θ value	5.27518 (rank : 80)	NC score	0.004163 (rank : 112)
Query Neighborhood Hits	119	Target Neighborhood Hits	375	Shared Neighborhood Hits	9
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

CO4A3_HUMAN
θ value	5.27518 (rank : 81)	NC score	0.010477 (rank : 91)
Query Neighborhood Hits	119	Target Neighborhood Hits	421	Shared Neighborhood Hits	19
SwissProt Accessions	Q01955, Q9BQT2	Gene names	COL4A3
Domain Architecture
Description	Collagen alpha-3(IV) chain precursor (Goodpasture antigen).

CO7A1_HUMAN
θ value	5.27518 (rank : 82)	NC score	0.007408 (rank : 103)
Query Neighborhood Hits	119	Target Neighborhood Hits	807	Shared Neighborhood Hits	23
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

CO8A2_HUMAN
θ value	5.27518 (rank : 83)	NC score	0.011727 (rank : 85)
Query Neighborhood Hits	119	Target Neighborhood Hits	299	Shared Neighborhood Hits	12
SwissProt Accessions	P25067, Q8TEJ5	Gene names	COL8A2
Domain Architecture
Description	Collagen alpha-2(VIII) chain precursor (Endothelial collagen).

CO8A2_MOUSE
θ value	5.27518 (rank : 84)	NC score	0.012121 (rank : 82)
Query Neighborhood Hits	119	Target Neighborhood Hits	273	Shared Neighborhood Hits	12
SwissProt Accessions	P25318, Q68ED0, Q6KAQ4, Q6P1C4	Gene names	Col8a2
Domain Architecture	No domain graphic available
Description	Collagen alpha-2(VIII) chain precursor (Endothelial collagen).

CU086_HUMAN
θ value	5.27518 (rank : 85)	NC score	0.028993 (rank : 40)
Query Neighborhood Hits	119	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	P59089	Gene names	C21orf86
Domain Architecture	No domain graphic available
Description	Protein C21orf86.

DMXL1_MOUSE
θ value	5.27518 (rank : 86)	NC score	0.009993 (rank : 92)
Query Neighborhood Hits	119	Target Neighborhood Hits	257	Shared Neighborhood Hits	6
SwissProt Accessions	Q6PNC0, Q3TLG8, Q6PHM6, Q8BQF2	Gene names	Dmxl1
Domain Architecture	No domain graphic available
Description	Protein DmX-like 1 (X-like 1 protein).

HCN4_MOUSE
θ value	5.27518 (rank : 87)	NC score	0.017640 (rank : 66)
Query Neighborhood Hits	119	Target Neighborhood Hits	284	Shared Neighborhood Hits	17
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

IER5_MOUSE
θ value	5.27518 (rank : 88)	NC score	0.019817 (rank : 59)
Query Neighborhood Hits	119	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	O89113, Q8CGI0	Gene names	Ier5
Domain Architecture	No domain graphic available
Description	Immediate early response gene 5 protein.

LNP_MOUSE
θ value	5.27518 (rank : 89)	NC score	0.018095 (rank : 62)
Query Neighborhood Hits	119	Target Neighborhood Hits	83	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TQ95, Q69ZC5, Q6PAQ1, Q6PEN8	Gene names	Lnp, Kiaa1715, Uln
Domain Architecture	No domain graphic available
Description	Protein lunapark (Protein ulnaless).

PKD1_HUMAN
θ value	5.27518 (rank : 90)	NC score	0.007592 (rank : 100)
Query Neighborhood Hits	119	Target Neighborhood Hits	387	Shared Neighborhood Hits	4
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

PTPRR_HUMAN
θ value	5.27518 (rank : 91)	NC score	0.004537 (rank : 111)
Query Neighborhood Hits	119	Target Neighborhood Hits	77	Shared Neighborhood Hits	2
SwissProt Accessions	Q15256, O00342, Q92682, Q9UE65	Gene names	PTPRR, ECPTP
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase).

SFPQ_HUMAN
θ value	5.27518 (rank : 92)	NC score	0.015345 (rank : 69)
Query Neighborhood Hits	119	Target Neighborhood Hits	986	Shared Neighborhood Hits	19
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

SFPQ_MOUSE
θ value	5.27518 (rank : 93)	NC score	0.014519 (rank : 72)
Query Neighborhood Hits	119	Target Neighborhood Hits	958	Shared Neighborhood Hits	18
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

STRN4_HUMAN
θ value	5.27518 (rank : 94)	NC score	0.011391 (rank : 89)
Query Neighborhood Hits	119	Target Neighborhood Hits	325	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NRL3	Gene names	STRN4, ZIN
Domain Architecture
Description	Striatin-4 (Zinedin).

STRN4_MOUSE
θ value	5.27518 (rank : 95)	NC score	0.011446 (rank : 88)
Query Neighborhood Hits	119	Target Neighborhood Hits	324	Shared Neighborhood Hits	7
SwissProt Accessions	P58404, Q68EF5	Gene names	Strn4, Zin
Domain Architecture
Description	Striatin-4 (Zinedin).

ZN692_MOUSE
θ value	5.27518 (rank : 96)	NC score	-0.000348 (rank : 120)
Query Neighborhood Hits	119	Target Neighborhood Hits	751	Shared Neighborhood Hits	7
SwissProt Accessions	Q3U381	Gene names	Znf692, Zfp692
Domain Architecture	No domain graphic available
Description	Zinc finger protein 692.

BCL9_HUMAN
θ value	6.88961 (rank : 97)	NC score	0.023222 (rank : 50)
Query Neighborhood Hits	119	Target Neighborhood Hits	1008	Shared Neighborhood Hits	45
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

DLDH_HUMAN
θ value	6.88961 (rank : 98)	NC score	0.014262 (rank : 74)
Query Neighborhood Hits	119	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	P09622, Q14131, Q14167	Gene names	DLD, GCSL, LAD, PHE3
Domain Architecture
Description	Dihydrolipoyl dehydrogenase, mitochondrial precursor (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein).

DLDH_MOUSE
θ value	6.88961 (rank : 99)	NC score	0.014264 (rank : 73)
Query Neighborhood Hits	119	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	O08749	Gene names	Dld
Domain Architecture
Description	Dihydrolipoyl dehydrogenase, mitochondrial precursor (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase).

EGF_HUMAN
θ value	6.88961 (rank : 100)	NC score	0.012803 (rank : 78)
Query Neighborhood Hits	119	Target Neighborhood Hits	343	Shared Neighborhood Hits	5
SwissProt Accessions	P01133	Gene names	EGF
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor (Urogastrone)].

MUC2_HUMAN
θ value	6.88961 (rank : 101)	NC score	0.007472 (rank : 102)
Query Neighborhood Hits	119	Target Neighborhood Hits	906	Shared Neighborhood Hits	16
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

NKTR_HUMAN
θ value	6.88961 (rank : 102)	NC score	0.006627 (rank : 106)
Query Neighborhood Hits	119	Target Neighborhood Hits	658	Shared Neighborhood Hits	10
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

PITM1_HUMAN
θ value	6.88961 (rank : 103)	NC score	0.008814 (rank : 97)
Query Neighborhood Hits	119	Target Neighborhood Hits	129	Shared Neighborhood Hits	10
SwissProt Accessions	O00562, Q6T7X3, Q8TBN3, Q9BZ73	Gene names	PITPNM1, DRES9, NIR2, PITPNM
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 1 (Phosphatidylinositol transfer protein, membrane-associated 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) (Drosophila retinal degeneration B homolog).

RBP2_MOUSE
θ value	6.88961 (rank : 104)	NC score	0.006376 (rank : 107)
Query Neighborhood Hits	119	Target Neighborhood Hits	232	Shared Neighborhood Hits	5
SwissProt Accessions	Q9ERU9, Q61992, Q8C9K9	Gene names	Ranbp2
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2 (RanBP2).

SCOT2_HUMAN
θ value	6.88961 (rank : 105)	NC score	0.011926 (rank : 83)
Query Neighborhood Hits	119	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BYC2, Q8NHR1, Q9H1I4	Gene names	OXCT2
Domain Architecture
Description	Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial precursor (EC 2.8.3.5) (Testis-specific succinyl CoA:3-oxoacid CoA- transferase) (SCOT-t).

SPTA3_MOUSE
θ value	6.88961 (rank : 106)	NC score	0.025945 (rank : 44)
Query Neighborhood Hits	119	Target Neighborhood Hits	74	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D9T6, Q80ZS4, Q9D5L5, Q9DAF5	Gene names	Spata3, Tsarg1
Domain Architecture	No domain graphic available
Description	Spermatogenesis-associated protein 3 (Testis spermatocyte apoptosis- related protein 1) (Testis and spermatogenesis cell-related protein 1) (mTSARG1).

ALEX_HUMAN
θ value	8.99809 (rank : 107)	NC score	0.019727 (rank : 60)
Query Neighborhood Hits	119	Target Neighborhood Hits	361	Shared Neighborhood Hits	18
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

ALEX_MOUSE
θ value	8.99809 (rank : 108)	NC score	0.018086 (rank : 63)
Query Neighborhood Hits	119	Target Neighborhood Hits	197	Shared Neighborhood Hits	11
SwissProt Accessions	Q6R0H6, Q8BIR3	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

AT132_MOUSE
θ value	8.99809 (rank : 109)	NC score	0.009117 (rank : 95)
Query Neighborhood Hits	119	Target Neighborhood Hits	69	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CTG6, Q8CG98	Gene names	Atp13a2
Domain Architecture	No domain graphic available
Description	Probable cation-transporting ATPase 13A2 (EC 3.6.3.-).

E2F3_MOUSE
θ value	8.99809 (rank : 110)	NC score	0.006957 (rank : 105)
Query Neighborhood Hits	119	Target Neighborhood Hits	47	Shared Neighborhood Hits	3
SwissProt Accessions	O35261, Q5T0I6	Gene names	E2f3
Domain Architecture	No domain graphic available
Description	Transcription factor E2F3 (E2F-3).

GLPC_HUMAN
θ value	8.99809 (rank : 111)	NC score	0.017687 (rank : 65)
Query Neighborhood Hits	119	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	P04921, Q92642	Gene names	GYPC, GPC
Domain Architecture
Description	Glycophorin C (PAS-2') (Glycoprotein beta) (GLPC) (Glycoconnectin) (Sialoglycoprotein D) (Glycophorin D) (GPD) (CD236 antigen).

HCN4_HUMAN
θ value	8.99809 (rank : 112)	NC score	0.015491 (rank : 68)
Query Neighborhood Hits	119	Target Neighborhood Hits	303	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

RSMN_HUMAN
θ value	8.99809 (rank : 113)	NC score	0.013873 (rank : 76)
Query Neighborhood Hits	119	Target Neighborhood Hits	110	Shared Neighborhood Hits	6
SwissProt Accessions	P63162, P14648, P17135	Gene names	SNRPN, HCERN3, SMN
Domain Architecture	No domain graphic available
Description	Small nuclear ribonucleoprotein-associated protein N (snRNP-N) (Sm protein N) (Sm-N) (SmN) (Sm-D) (Tissue-specific-splicing protein).

RSMN_MOUSE
θ value	8.99809 (rank : 114)	NC score	0.013873 (rank : 77)
Query Neighborhood Hits	119	Target Neighborhood Hits	110	Shared Neighborhood Hits	6
SwissProt Accessions	P63163, P14648, P17135	Gene names	Snrpn, Smn
Domain Architecture	No domain graphic available
Description	Small nuclear ribonucleoprotein-associated protein N (snRNP-N) (Sm protein N) (Sm-N) (SmN) (Sm-D) (Tissue-specific-splicing protein).

SALL3_HUMAN
θ value	8.99809 (rank : 115)	NC score	0.000005 (rank : 119)
Query Neighborhood Hits	119	Target Neighborhood Hits	1066	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BXA9, Q9UGH1	Gene names	SALL3
Domain Architecture	No domain graphic available
Description	Sal-like protein 3 (Zinc finger protein SALL3) (hSALL3).

SPEG_HUMAN
θ value	8.99809 (rank : 116)	NC score	0.000742 (rank : 116)
Query Neighborhood Hits	119	Target Neighborhood Hits	1762	Shared Neighborhood Hits	27
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

TNK1_MOUSE
θ value	8.99809 (rank : 117)	NC score	0.004581 (rank : 110)
Query Neighborhood Hits	119	Target Neighborhood Hits	806	Shared Neighborhood Hits	8
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

VINC_HUMAN
θ value	8.99809 (rank : 118)	NC score	0.011767 (rank : 84)
Query Neighborhood Hits	119	Target Neighborhood Hits	145	Shared Neighborhood Hits	4
SwissProt Accessions	P18206, Q16450, Q5SWX2, Q7Z3B8, Q8IXU7	Gene names	VCL
Domain Architecture
Description	Vinculin (Metavinculin).

VINC_MOUSE
θ value	8.99809 (rank : 119)	NC score	0.010712 (rank : 90)
Query Neighborhood Hits	119	Target Neighborhood Hits	135	Shared Neighborhood Hits	3
SwissProt Accessions	Q64727, Q8BP32, Q8BS46, Q922C5, Q922D9	Gene names	Vcl
Domain Architecture
Description	Vinculin (Metavinculin).

PUR2_MOUSE
θ value	θ > 10 (rank : 120)	NC score	0.070447 (rank : 28)
Query Neighborhood Hits	119	Target Neighborhood Hits	18	Shared Neighborhood Hits	6
SwissProt Accessions	Q64737, Q6NS48	Gene names	Gart
Domain Architecture
Description	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)].

Hits sorted by NC score

PYR1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	119	Target Neighborhood Hits	119	Shared Neighborhood Hits	119
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].

CPSM_HUMAN
NC score	0.918234 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	119	Target Neighborhood Hits	27	Shared Neighborhood Hits	13
SwissProt Accessions	P31327, O43774, Q7Z5I5	Gene names	CPS1
Domain Architecture
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

CPSM_MOUSE
NC score	0.917954 (rank : 3)	θ value	0 (rank : 2)
Query Neighborhood Hits	119	Target Neighborhood Hits	32	Shared Neighborhood Hits	13
SwissProt Accessions	Q8C196, Q6NX75	Gene names	Cps1
Domain Architecture	No domain graphic available
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

PYC_MOUSE
NC score	0.408544 (rank : 4)	θ value	1.2105e-12 (rank : 6)
Query Neighborhood Hits	119	Target Neighborhood Hits	25	Shared Neighborhood Hits	11
SwissProt Accessions	Q05920	Gene names	Pc, Pcx
Domain Architecture
Description	Pyruvate carboxylase, mitochondrial precursor (EC 6.4.1.1) (Pyruvic carboxylase) (PCB).

PYC_HUMAN
NC score	0.403585 (rank : 5)	θ value	4.59992e-12 (rank : 7)
Query Neighborhood Hits	119	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	P11498, Q16705	Gene names	PC
Domain Architecture
Description	Pyruvate carboxylase, mitochondrial precursor (EC 6.4.1.1) (Pyruvic carboxylase) (PCB).

COA1_HUMAN
NC score	0.396358 (rank : 6)	θ value	7.84624e-12 (rank : 8)
Query Neighborhood Hits	119	Target Neighborhood Hits	49	Shared Neighborhood Hits	13
SwissProt Accessions	Q13085	Gene names	ACACA, ACAC, ACC1, ACCA
Domain Architecture
Description	Acetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)].

PCCA_MOUSE
NC score	0.393927 (rank : 7)	θ value	1.63604e-09 (rank : 11)
Query Neighborhood Hits	119	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	Q91ZA3, Q80VU5, Q922N3	Gene names	Pcca
Domain Architecture	No domain graphic available
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

PCCA_HUMAN
NC score	0.392575 (rank : 8)	θ value	9.59137e-10 (rank : 10)
Query Neighborhood Hits	119	Target Neighborhood Hits	22	Shared Neighborhood Hits	12
SwissProt Accessions	P05165, Q15979	Gene names	PCCA
Domain Architecture
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

MCCA_HUMAN
NC score	0.391790 (rank : 9)	θ value	1.99992e-07 (rank : 13)
Query Neighborhood Hits	119	Target Neighborhood Hits	26	Shared Neighborhood Hits	13
SwissProt Accessions	Q96RQ3, Q59ES4, Q9H959, Q9NS97	Gene names	MCCC1, MCCA
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

MCCA_MOUSE
NC score	0.367421 (rank : 10)	θ value	0.00035302 (rank : 24)
Query Neighborhood Hits	119	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	Q99MR8, Q3TGU0, Q9D8R2	Gene names	Mccc1, Mcca
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

OTC_MOUSE
NC score	0.364949 (rank : 11)	θ value	2.06002e-20 (rank : 4)
Query Neighborhood Hits	119	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	P11725	Gene names	Otc
Domain Architecture
Description	Ornithine carbamoyltransferase, mitochondrial precursor (EC 2.1.3.3) (OTCase) (Ornithine transcarbamylase).

OTC_HUMAN
NC score	0.360353 (rank : 12)	θ value	1.33526e-19 (rank : 5)
Query Neighborhood Hits	119	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	P00480, Q6B0I1, Q9NYJ5	Gene names	OTC
Domain Architecture
Description	Ornithine carbamoyltransferase, mitochondrial precursor (EC 2.1.3.3) (OTCase) (Ornithine transcarbamylase).

COA2_HUMAN
NC score	0.351412 (rank : 13)	θ value	7.34386e-10 (rank : 9)
Query Neighborhood Hits	119	Target Neighborhood Hits	184	Shared Neighborhood Hits	12
SwissProt Accessions	O00763, Q16852	Gene names	ACACB, ACC2, ACCB
Domain Architecture
Description	Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) [Includes: Biotin carboxylase (EC 6.3.4.14)].

DPYL4_MOUSE
NC score	0.259396 (rank : 14)	θ value	1.80886e-08 (rank : 12)
Query Neighborhood Hits	119	Target Neighborhood Hits	21	Shared Neighborhood Hits	13
SwissProt Accessions	O35098, O08886	Gene names	Dpysl4, Crmp3, Ulip4
Domain Architecture
Description	Dihydropyrimidinase-related protein 4 (DRP-4) (Collapsin response mediator protein 3) (CRMP-3) (UNC33-like phosphoprotein 4) (ULIP4 protein).

DPYL4_HUMAN
NC score	0.255802 (rank : 15)	θ value	2.61198e-07 (rank : 14)
Query Neighborhood Hits	119	Target Neighborhood Hits	25	Shared Neighborhood Hits	13
SwissProt Accessions	O14531, O00240, Q5T0Q7	Gene names	DPYSL4, CRMP3, ULIP4
Domain Architecture
Description	Dihydropyrimidinase-related protein 4 (DRP-4) (Collapsin response mediator protein 3) (CRMP-3) (UNC33-like phosphoprotein 4) (ULIP4 protein).

DPYL5_MOUSE
NC score	0.253278 (rank : 16)	θ value	2.88788e-06 (rank : 15)
Query Neighborhood Hits	119	Target Neighborhood Hits	18	Shared Neighborhood Hits	13
SwissProt Accessions	Q9EQF6	Gene names	Dpysl5, Crmp5
Domain Architecture
Description	Dihydropyrimidinase-related protein 5 (DRP-5) (Collapsin response mediator protein 5) (CRMP-5).

DPYL5_HUMAN
NC score	0.248148 (rank : 17)	θ value	7.1131e-05 (rank : 18)
Query Neighborhood Hits	119	Target Neighborhood Hits	20	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BPU6, Q8TCL6, Q9NQC4, Q9NRY9	Gene names	DPYSL5, CRMP5, ULIP6
Domain Architecture
Description	Dihydropyrimidinase-related protein 5 (DRP-5) (ULIP6 protein) (Collapsin response mediator protein 5) (CRMP-5) (CRMP3-associated molecule) (CRAM).

DPYL3_MOUSE
NC score	0.247768 (rank : 18)	θ value	3.19293e-05 (rank : 17)
Query Neighborhood Hits	119	Target Neighborhood Hits	19	Shared Neighborhood Hits	13
SwissProt Accessions	Q62188	Gene names	Dpysl3, Drp3, Ulip
Domain Architecture
Description	Dihydropyrimidinase-related protein 3 (DRP-3) (Unc-33-like phosphoprotein) (ULIP protein).

DPYL3_HUMAN
NC score	0.247706 (rank : 19)	θ value	3.19293e-05 (rank : 16)
Query Neighborhood Hits	119	Target Neighborhood Hits	20	Shared Neighborhood Hits	13
SwissProt Accessions	Q14195, Q93012	Gene names	DPYSL3, CRMP4, DRP3, ULIP
Domain Architecture
Description	Dihydropyrimidinase-related protein 3 (DRP-3) (Unc-33-like phosphoprotein) (ULIP protein) (Collapsin response mediator protein 4) (CRMP-4).

DPYS_MOUSE
NC score	0.246805 (rank : 20)	θ value	9.29e-05 (rank : 19)
Query Neighborhood Hits	119	Target Neighborhood Hits	18	Shared Neighborhood Hits	13
SwissProt Accessions	Q9EQF5, Q99PP1, Q9DBK3, Q9DBP7	Gene names	Dpys
Domain Architecture
Description	Dihydropyrimidinase (EC 3.5.2.2) (DHPase) (Hydantoinase) (DHP).

DPYL2_HUMAN
NC score	0.245323 (rank : 21)	θ value	0.000121331 (rank : 20)
Query Neighborhood Hits	119	Target Neighborhood Hits	19	Shared Neighborhood Hits	13
SwissProt Accessions	Q16555, O00424	Gene names	DPYSL2, CRMP2
Domain Architecture
Description	Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3).

DPYS_HUMAN
NC score	0.244718 (rank : 22)	θ value	0.00035302 (rank : 23)
Query Neighborhood Hits	119	Target Neighborhood Hits	17	Shared Neighborhood Hits	13
SwissProt Accessions	Q14117	Gene names	DPYS
Domain Architecture
Description	Dihydropyrimidinase (EC 3.5.2.2) (DHPase) (Hydantoinase) (DHP).

DPYL2_MOUSE
NC score	0.244051 (rank : 23)	θ value	0.000270298 (rank : 21)
Query Neighborhood Hits	119	Target Neighborhood Hits	21	Shared Neighborhood Hits	13
SwissProt Accessions	O08553, Q6P5D0	Gene names	Dpysl2, Crmp2, Ulip2
Domain Architecture	No domain graphic available
Description	Dihydropyrimidinase-related protein 2 (DRP-2) (ULIP 2 protein).

DPYL1_MOUSE
NC score	0.243651 (rank : 24)	θ value	0.00035302 (rank : 22)
Query Neighborhood Hits	119	Target Neighborhood Hits	17	Shared Neighborhood Hits	13
SwissProt Accessions	P97427, O08554, O35097	Gene names	Crmp1, Dpysl1, Ulip3
Domain Architecture
Description	Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (ULIP3 protein).

DPYL1_HUMAN
NC score	0.241371 (rank : 25)	θ value	0.00134147 (rank : 25)
Query Neighborhood Hits	119	Target Neighborhood Hits	16	Shared Neighborhood Hits	13
SwissProt Accessions	Q14194, Q13024, Q96TC8	Gene names	CRMP1, DPYSL1
Domain Architecture
Description	Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1).

GUAA_HUMAN
NC score	0.142600 (rank : 26)	θ value	0.0961366 (rank : 30)
Query Neighborhood Hits	119	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	P49915	Gene names	GMPS
Domain Architecture
Description	GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (Glutamine amidotransferase) (GMP synthetase).

PUR2_HUMAN
NC score	0.085450 (rank : 27)	θ value	0.163984 (rank : 32)
Query Neighborhood Hits	119	Target Neighborhood Hits	21	Shared Neighborhood Hits	9
SwissProt Accessions	P22102	Gene names	GART, PRGS
Domain Architecture
Description	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)].

PUR2_MOUSE
NC score	0.070447 (rank : 28)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	119	Target Neighborhood Hits	18	Shared Neighborhood Hits	6
SwissProt Accessions	Q64737, Q6NS48	Gene names	Gart
Domain Architecture
Description	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)].

ATX7_HUMAN
NC score	0.067833 (rank : 29)	θ value	0.00869519 (rank : 26)
Query Neighborhood Hits	119	Target Neighborhood Hits	351	Shared Neighborhood Hits	26
SwissProt Accessions	O15265, O75328, O75329, Q9Y6P8	Gene names	ATXN7, SCA7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein).

LCP2_MOUSE
NC score	0.049573 (rank : 30)	θ value	0.21417 (rank : 33)
Query Neighborhood Hits	119	Target Neighborhood Hits	177	Shared Neighborhood Hits	7
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_HUMAN
NC score	0.043103 (rank : 31)	θ value	1.06291 (rank : 43)
Query Neighborhood Hits	119	Target Neighborhood Hits	531	Shared Neighborhood Hits	28
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

ZN541_HUMAN
NC score	0.041053 (rank : 32)	θ value	0.21417 (rank : 35)
Query Neighborhood Hits	119	Target Neighborhood Hits	203	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H0D2, Q8NDK8	Gene names	ZNF541
Domain Architecture	No domain graphic available
Description	Zinc finger protein 541.

WBP11_MOUSE
NC score	0.039717 (rank : 33)	θ value	1.06291 (rank : 47)
Query Neighborhood Hits	119	Target Neighborhood Hits	362	Shared Neighborhood Hits	13
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

WBP11_HUMAN
NC score	0.039557 (rank : 34)	θ value	1.06291 (rank : 46)
Query Neighborhood Hits	119	Target Neighborhood Hits	354	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

WASL_HUMAN
NC score	0.036365 (rank : 35)	θ value	0.813845 (rank : 41)
Query Neighborhood Hits	119	Target Neighborhood Hits	312	Shared Neighborhood Hits	15
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

CS021_MOUSE
NC score	0.034481 (rank : 36)	θ value	0.813845 (rank : 39)
Query Neighborhood Hits	119	Target Neighborhood Hits	47	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D279, Q3UI04	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf21 homolog.

PRCC_HUMAN
NC score	0.031795 (rank : 37)	θ value	3.0926 (rank : 69)
Query Neighborhood Hits	119	Target Neighborhood Hits	109	Shared Neighborhood Hits	6
SwissProt Accessions	Q92733, O00665, O00724	Gene names	PRCC, TPRC
Domain Architecture	No domain graphic available
Description	Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein).

WASL_MOUSE
NC score	0.031478 (rank : 38)	θ value	2.36792 (rank : 64)
Query Neighborhood Hits	119	Target Neighborhood Hits	339	Shared Neighborhood Hits	14
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

RTN4_MOUSE
NC score	0.030014 (rank : 39)	θ value	0.21417 (rank : 34)
Query Neighborhood Hits	119	Target Neighborhood Hits	341	Shared Neighborhood Hits	10
SwissProt Accessions	Q99P72, Q5DTK9, Q7TNB7, Q80W95, Q8BGK7, Q8BGM9, Q8K290, Q8K3G8, Q9CTE3	Gene names	Rtn4, Kiaa0886, Nogo
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein).

CU086_HUMAN
NC score	0.028993 (rank : 40)	θ value	5.27518 (rank : 85)
Query Neighborhood Hits	119	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	P59089	Gene names	C21orf86
Domain Architecture	No domain graphic available
Description	Protein C21orf86.

NCOA6_HUMAN
NC score	0.028333 (rank : 41)	θ value	1.38821 (rank : 50)
Query Neighborhood Hits	119	Target Neighborhood Hits	1202	Shared Neighborhood Hits	46
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

INGR1_HUMAN
NC score	0.027946 (rank : 42)	θ value	1.81305 (rank : 52)
Query Neighborhood Hits	119	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	P15260	Gene names	IFNGR1
Domain Architecture
Description	Interferon-gamma receptor alpha chain precursor (IFN-gamma-R1) (CD119 antigen) (CDw119).

NGN1_HUMAN
NC score	0.026204 (rank : 43)	θ value	0.279714 (rank : 36)
Query Neighborhood Hits	119	Target Neighborhood Hits	83	Shared Neighborhood Hits	2
SwissProt Accessions	Q92886, Q96HE1	Gene names	NEUROG1, NEUROD3, NGN, NGN1
Domain Architecture
Description	Neurogenin 1 (Neurogenic differentiation factor 3) (NeuroD3) (Neurogenic basic-helix-loop-helix protein).

SPTA3_MOUSE
NC score	0.025945 (rank : 44)	θ value	6.88961 (rank : 106)
Query Neighborhood Hits	119	Target Neighborhood Hits	74	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D9T6, Q80ZS4, Q9D5L5, Q9DAF5	Gene names	Spata3, Tsarg1
Domain Architecture	No domain graphic available
Description	Spermatogenesis-associated protein 3 (Testis spermatocyte apoptosis- related protein 1) (Testis and spermatogenesis cell-related protein 1) (mTSARG1).

ADDA_MOUSE
NC score	0.025292 (rank : 45)	θ value	0.365318 (rank : 37)
Query Neighborhood Hits	119	Target Neighborhood Hits	198	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QYC0, Q9JLE3	Gene names	Add1
Domain Architecture
Description	Alpha-adducin (Erythrocyte adducin subunit alpha).

TAF1C_HUMAN
NC score	0.023983 (rank : 46)	θ value	2.36792 (rank : 63)
Query Neighborhood Hits	119	Target Neighborhood Hits	36	Shared Neighborhood Hits	3
SwissProt Accessions	Q15572, Q59F67, Q8N6V3	Gene names	TAF1C
Domain Architecture	No domain graphic available
Description	TATA box-binding protein-associated factor RNA polymerase I subunit C (TATA box-binding protein-associated factor 1C) (TBP-associated factor 1C) (TBP-associated factor RNA polymerase I 110 kDa) (TAFI110).

CBP_HUMAN
NC score	0.023951 (rank : 47)	θ value	2.36792 (rank : 59)
Query Neighborhood Hits	119	Target Neighborhood Hits	941	Shared Neighborhood Hits	27
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

HCN2_HUMAN
NC score	0.023808 (rank : 48)	θ value	0.163984 (rank : 31)
Query Neighborhood Hits	119	Target Neighborhood Hits	369	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

MADCA_HUMAN
NC score	0.023334 (rank : 49)	θ value	3.0926 (rank : 68)
Query Neighborhood Hits	119	Target Neighborhood Hits	221	Shared Neighborhood Hits	9
SwissProt Accessions	Q13477, O60222, O75867	Gene names	MADCAM1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (hMAdCAM-1).

BCL9_HUMAN
NC score	0.023222 (rank : 50)	θ value	6.88961 (rank : 97)
Query Neighborhood Hits	119	Target Neighborhood Hits	1008	Shared Neighborhood Hits	45
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

SRRM1_MOUSE
NC score	0.022350 (rank : 51)	θ value	2.36792 (rank : 62)
Query Neighborhood Hits	119	Target Neighborhood Hits	966	Shared Neighborhood Hits	32
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

EGF_MOUSE
NC score	0.022308 (rank : 52)	θ value	0.0148317 (rank : 27)
Query Neighborhood Hits	119	Target Neighborhood Hits	358	Shared Neighborhood Hits	4
SwissProt Accessions	P01132, Q6P9J2	Gene names	Egf
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor].

CBP_MOUSE
NC score	0.022124 (rank : 53)	θ value	4.03905 (rank : 72)
Query Neighborhood Hits	119	Target Neighborhood Hits	1051	Shared Neighborhood Hits	32
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

SON_HUMAN
NC score	0.021465 (rank : 54)	θ value	4.03905 (rank : 78)
Query Neighborhood Hits	119	Target Neighborhood Hits	1568	Shared Neighborhood Hits	55
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

YLPM1_MOUSE
NC score	0.021082 (rank : 55)	θ value	3.0926 (rank : 71)
Query Neighborhood Hits	119	Target Neighborhood Hits	505	Shared Neighborhood Hits	14
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

SAPS1_HUMAN
NC score	0.020328 (rank : 56)	θ value	2.36792 (rank : 61)
Query Neighborhood Hits	119	Target Neighborhood Hits	704	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

BRD4_HUMAN
NC score	0.019942 (rank : 57)	θ value	2.36792 (rank : 56)
Query Neighborhood Hits	119	Target Neighborhood Hits	851	Shared Neighborhood Hits	16
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

BRD4_MOUSE
NC score	0.019901 (rank : 58)	θ value	2.36792 (rank : 57)
Query Neighborhood Hits	119	Target Neighborhood Hits	845	Shared Neighborhood Hits	18
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

IER5_MOUSE
NC score	0.019817 (rank : 59)	θ value	5.27518 (rank : 88)
Query Neighborhood Hits	119	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	O89113, Q8CGI0	Gene names	Ier5
Domain Architecture	No domain graphic available
Description	Immediate early response gene 5 protein.

ALEX_HUMAN
NC score	0.019727 (rank : 60)	θ value	8.99809 (rank : 107)
Query Neighborhood Hits	119	Target Neighborhood Hits	361	Shared Neighborhood Hits	18
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

SRBS1_HUMAN
NC score	0.018415 (rank : 61)	θ value	1.06291 (rank : 44)
Query Neighborhood Hits	119	Target Neighborhood Hits	396	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

LNP_MOUSE
NC score	0.018095 (rank : 62)	θ value	5.27518 (rank : 89)
Query Neighborhood Hits	119	Target Neighborhood Hits	83	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TQ95, Q69ZC5, Q6PAQ1, Q6PEN8	Gene names	Lnp, Kiaa1715, Uln
Domain Architecture	No domain graphic available
Description	Protein lunapark (Protein ulnaless).

ALEX_MOUSE
NC score	0.018086 (rank : 63)	θ value	8.99809 (rank : 108)
Query Neighborhood Hits	119	Target Neighborhood Hits	197	Shared Neighborhood Hits	11
SwissProt Accessions	Q6R0H6, Q8BIR3	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

PCX3_MOUSE
NC score	0.017741 (rank : 64)	θ value	4.03905 (rank : 77)
Query Neighborhood Hits	119	Target Neighborhood Hits	134	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VI59	Gene names	Pcnxl3
Domain Architecture
Description	Pecanex-like protein 3.

GLPC_HUMAN
NC score	0.017687 (rank : 65)	θ value	8.99809 (rank : 111)
Query Neighborhood Hits	119	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	P04921, Q92642	Gene names	GYPC, GPC
Domain Architecture
Description	Glycophorin C (PAS-2') (Glycoprotein beta) (GLPC) (Glycoconnectin) (Sialoglycoprotein D) (Glycophorin D) (GPD) (CD236 antigen).

HCN4_MOUSE
NC score	0.017640 (rank : 66)	θ value	5.27518 (rank : 87)
Query Neighborhood Hits	119	Target Neighborhood Hits	284	Shared Neighborhood Hits	17
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

FMN2_HUMAN
NC score	0.015939 (rank : 67)	θ value	4.03905 (rank : 75)
Query Neighborhood Hits	119	Target Neighborhood Hits	484	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

HCN4_HUMAN
NC score	0.015491 (rank : 68)	θ value	8.99809 (rank : 112)
Query Neighborhood Hits	119	Target Neighborhood Hits	303	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

SFPQ_HUMAN
NC score	0.015345 (rank : 69)	θ value	5.27518 (rank : 92)
Query Neighborhood Hits	119	Target Neighborhood Hits	986	Shared Neighborhood Hits	19
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

DYN2_HUMAN
NC score	0.014987 (rank : 70)	θ value	1.81305 (rank : 51)
Query Neighborhood Hits	119	Target Neighborhood Hits	112	Shared Neighborhood Hits	8
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

CO4A5_HUMAN
NC score	0.014967 (rank : 71)	θ value	2.36792 (rank : 60)
Query Neighborhood Hits	119	Target Neighborhood Hits	383	Shared Neighborhood Hits	16
SwissProt Accessions	P29400, Q16006, Q16126, Q6LD84	Gene names	COL4A5
Domain Architecture
Description	Collagen alpha-5(IV) chain precursor.

SFPQ_MOUSE
NC score	0.014519 (rank : 72)	θ value	5.27518 (rank : 93)
Query Neighborhood Hits	119	Target Neighborhood Hits	958	Shared Neighborhood Hits	18
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

DLDH_MOUSE
NC score	0.014264 (rank : 73)	θ value	6.88961 (rank : 99)
Query Neighborhood Hits	119	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	O08749	Gene names	Dld
Domain Architecture
Description	Dihydrolipoyl dehydrogenase, mitochondrial precursor (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase).

DLDH_HUMAN
NC score	0.014262 (rank : 74)	θ value	6.88961 (rank : 98)
Query Neighborhood Hits	119	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	P09622, Q14131, Q14167	Gene names	DLD, GCSL, LAD, PHE3
Domain Architecture
Description	Dihydrolipoyl dehydrogenase, mitochondrial precursor (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein).

AT1A4_MOUSE
NC score	0.014228 (rank : 75)	θ value	0.62314 (rank : 38)
Query Neighborhood Hits	119	Target Neighborhood Hits	63	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WV27, Q9R173, Q9WV28	Gene names	Atp1a4, Atp1al2
Domain Architecture
Description	Sodium/potassium-transporting ATPase alpha-4 chain (EC 3.6.3.9) (Sodium pump 4) (Na+/K+ ATPase 4).

RSMN_HUMAN
NC score	0.013873 (rank : 76)	θ value	8.99809 (rank : 113)
Query Neighborhood Hits	119	Target Neighborhood Hits	110	Shared Neighborhood Hits	6
SwissProt Accessions	P63162, P14648, P17135	Gene names	SNRPN, HCERN3, SMN
Domain Architecture	No domain graphic available
Description	Small nuclear ribonucleoprotein-associated protein N (snRNP-N) (Sm protein N) (Sm-N) (SmN) (Sm-D) (Tissue-specific-splicing protein).

RSMN_MOUSE
NC score	0.013873 (rank : 77)	θ value	8.99809 (rank : 114)
Query Neighborhood Hits	119	Target Neighborhood Hits	110	Shared Neighborhood Hits	6
SwissProt Accessions	P63163, P14648, P17135	Gene names	Snrpn, Smn
Domain Architecture	No domain graphic available
Description	Small nuclear ribonucleoprotein-associated protein N (snRNP-N) (Sm protein N) (Sm-N) (SmN) (Sm-D) (Tissue-specific-splicing protein).

EGF_HUMAN
NC score	0.012803 (rank : 78)	θ value	6.88961 (rank : 100)
Query Neighborhood Hits	119	Target Neighborhood Hits	343	Shared Neighborhood Hits	5
SwissProt Accessions	P01133	Gene names	EGF
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor (Urogastrone)].

STRN3_MOUSE
NC score	0.012702 (rank : 79)	θ value	3.0926 (rank : 70)
Query Neighborhood Hits	119	Target Neighborhood Hits	309	Shared Neighborhood Hits	6
SwissProt Accessions	Q9ERG2	Gene names	Strn3, Gs2na, Sg2na
Domain Architecture
Description	Striatin-3 (Cell-cycle autoantigen SG2NA) (S/G2 antigen).

SEM6C_MOUSE
NC score	0.012281 (rank : 80)	θ value	1.81305 (rank : 55)
Query Neighborhood Hits	119	Target Neighborhood Hits	352	Shared Neighborhood Hits	28
SwissProt Accessions	Q9WTM3	Gene names	Sema6c, Semay
Domain Architecture
Description	Semaphorin-6C precursor (Semaphorin Y) (Sema Y).

GNAS1_HUMAN
NC score	0.012159 (rank : 81)	θ value	0.813845 (rank : 40)
Query Neighborhood Hits	119	Target Neighborhood Hits	278	Shared Neighborhood Hits	13
SwissProt Accessions	Q5JWF2, O75684, O75685, Q5JW67, Q5JWF1, Q9NY42	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

CO8A2_MOUSE
NC score	0.012121 (rank : 82)	θ value	5.27518 (rank : 84)
Query Neighborhood Hits	119	Target Neighborhood Hits	273	Shared Neighborhood Hits	12
SwissProt Accessions	P25318, Q68ED0, Q6KAQ4, Q6P1C4	Gene names	Col8a2
Domain Architecture	No domain graphic available
Description	Collagen alpha-2(VIII) chain precursor (Endothelial collagen).

SCOT2_HUMAN
NC score	0.011926 (rank : 83)	θ value	6.88961 (rank : 105)
Query Neighborhood Hits	119	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BYC2, Q8NHR1, Q9H1I4	Gene names	OXCT2
Domain Architecture
Description	Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial precursor (EC 2.8.3.5) (Testis-specific succinyl CoA:3-oxoacid CoA- transferase) (SCOT-t).

VINC_HUMAN
NC score	0.011767 (rank : 84)	θ value	8.99809 (rank : 118)
Query Neighborhood Hits	119	Target Neighborhood Hits	145	Shared Neighborhood Hits	4
SwissProt Accessions	P18206, Q16450, Q5SWX2, Q7Z3B8, Q8IXU7	Gene names	VCL
Domain Architecture
Description	Vinculin (Metavinculin).

CO8A2_HUMAN
NC score	0.011727 (rank : 85)	θ value	5.27518 (rank : 83)
Query Neighborhood Hits	119	Target Neighborhood Hits	299	Shared Neighborhood Hits	12
SwissProt Accessions	P25067, Q8TEJ5	Gene names	COL8A2
Domain Architecture
Description	Collagen alpha-2(VIII) chain precursor (Endothelial collagen).

BRWD1_MOUSE
NC score	0.011607 (rank : 86)	θ value	3.0926 (rank : 66)
Query Neighborhood Hits	119	Target Neighborhood Hits	478	Shared Neighborhood Hits	13
SwissProt Accessions	Q921C3, Q921C2	Gene names	Brwd1, Wdr9
Domain Architecture	No domain graphic available
Description	Bromodomain and WD repeat domain-containing protein 1 (WD repeat protein 9).

AT1A4_HUMAN
NC score	0.011460 (rank : 87)	θ value	3.0926 (rank : 65)
Query Neighborhood Hits	119	Target Neighborhood Hits	67	Shared Neighborhood Hits	4
SwissProt Accessions	Q13733, Q504T2, Q8TBN8, Q8WXA7, Q8WXH7, Q8WY13	Gene names	ATP1A4, ATP1AL2
Domain Architecture
Description	Sodium/potassium-transporting ATPase alpha-4 chain (EC 3.6.3.9) (Sodium pump 4) (Na+/K+ ATPase 4).

STRN4_MOUSE
NC score	0.011446 (rank : 88)	θ value	5.27518 (rank : 95)
Query Neighborhood Hits	119	Target Neighborhood Hits	324	Shared Neighborhood Hits	7
SwissProt Accessions	P58404, Q68EF5	Gene names	Strn4, Zin
Domain Architecture
Description	Striatin-4 (Zinedin).

STRN4_HUMAN
NC score	0.011391 (rank : 89)	θ value	5.27518 (rank : 94)
Query Neighborhood Hits	119	Target Neighborhood Hits	325	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NRL3	Gene names	STRN4, ZIN
Domain Architecture
Description	Striatin-4 (Zinedin).

VINC_MOUSE
NC score	0.010712 (rank : 90)	θ value	8.99809 (rank : 119)
Query Neighborhood Hits	119	Target Neighborhood Hits	135	Shared Neighborhood Hits	3
SwissProt Accessions	Q64727, Q8BP32, Q8BS46, Q922C5, Q922D9	Gene names	Vcl
Domain Architecture
Description	Vinculin (Metavinculin).

CO4A3_HUMAN
NC score	0.010477 (rank : 91)	θ value	5.27518 (rank : 81)
Query Neighborhood Hits	119	Target Neighborhood Hits	421	Shared Neighborhood Hits	19
SwissProt Accessions	Q01955, Q9BQT2	Gene names	COL4A3
Domain Architecture
Description	Collagen alpha-3(IV) chain precursor (Goodpasture antigen).

DMXL1_MOUSE
NC score	0.009993 (rank : 92)	θ value	5.27518 (rank : 86)
Query Neighborhood Hits	119	Target Neighborhood Hits	257	Shared Neighborhood Hits	6
SwissProt Accessions	Q6PNC0, Q3TLG8, Q6PHM6, Q8BQF2	Gene names	Dmxl1
Domain Architecture	No domain graphic available
Description	Protein DmX-like 1 (X-like 1 protein).

ACK1_HUMAN
NC score	0.009828 (rank : 93)	θ value	0.0563607 (rank : 28)
Query Neighborhood Hits	119	Target Neighborhood Hits	1140	Shared Neighborhood Hits	21
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

CAC1A_HUMAN
NC score	0.009319 (rank : 94)	θ value	2.36792 (rank : 58)
Query Neighborhood Hits	119	Target Neighborhood Hits	387	Shared Neighborhood Hits	18
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

AT132_MOUSE
NC score	0.009117 (rank : 95)	θ value	8.99809 (rank : 109)
Query Neighborhood Hits	119	Target Neighborhood Hits	69	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CTG6, Q8CG98	Gene names	Atp13a2
Domain Architecture	No domain graphic available
Description	Probable cation-transporting ATPase 13A2 (EC 3.6.3.-).

FOXI2_MOUSE
NC score	0.008929 (rank : 96)	θ value	1.38821 (rank : 48)
Query Neighborhood Hits	119	Target Neighborhood Hits	89	Shared Neighborhood Hits	2
SwissProt Accessions	Q3I5G5, Q8BIK9	Gene names	Foxi2
Domain Architecture	No domain graphic available
Description	Forkhead box protein I2.

PITM1_HUMAN
NC score	0.008814 (rank : 97)	θ value	6.88961 (rank : 103)
Query Neighborhood Hits	119	Target Neighborhood Hits	129	Shared Neighborhood Hits	10
SwissProt Accessions	O00562, Q6T7X3, Q8TBN3, Q9BZ73	Gene names	PITPNM1, DRES9, NIR2, PITPNM
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 1 (Phosphatidylinositol transfer protein, membrane-associated 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) (Drosophila retinal degeneration B homolog).

UBP36_HUMAN
NC score	0.008790 (rank : 98)	θ value	4.03905 (rank : 79)
Query Neighborhood Hits	119	Target Neighborhood Hits	232	Shared Neighborhood Hits	7
SwissProt Accessions	Q9P275, Q8NDM8, Q9NVC8	Gene names	USP36, KIAA1453
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.1.2.15) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) (Deubiquitinating enzyme 36).

LAMA5_MOUSE
NC score	0.008085 (rank : 99)	θ value	1.06291 (rank : 42)
Query Neighborhood Hits	119	Target Neighborhood Hits	828	Shared Neighborhood Hits	11
SwissProt Accessions	Q61001, Q9JHQ6	Gene names	Lama5
Domain Architecture
Description	Laminin alpha-5 chain precursor.

PKD1_HUMAN
NC score	0.007592 (rank : 100)	θ value	5.27518 (rank : 90)
Query Neighborhood Hits	119	Target Neighborhood Hits	387	Shared Neighborhood Hits	4
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

ADA2B_MOUSE
NC score	0.007540 (rank : 101)	θ value	0.0563607 (rank : 29)
Query Neighborhood Hits	119	Target Neighborhood Hits	891	Shared Neighborhood Hits	2
SwissProt Accessions	P30545	Gene names	Adra2b
Domain Architecture
Description	Alpha-2B adrenergic receptor (Alpha-2B adrenoceptor) (Alpha-2B adrenoreceptor).

MUC2_HUMAN
NC score	0.007472 (rank : 102)	θ value	6.88961 (rank : 101)
Query Neighborhood Hits	119	Target Neighborhood Hits	906	Shared Neighborhood Hits	16
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

CO7A1_HUMAN
NC score	0.007408 (rank : 103)	θ value	5.27518 (rank : 82)
Query Neighborhood Hits	119	Target Neighborhood Hits	807	Shared Neighborhood Hits	23
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

TNK1_HUMAN
NC score	0.006967 (rank : 104)	θ value	1.06291 (rank : 45)
Query Neighborhood Hits	119	Target Neighborhood Hits	815	Shared Neighborhood Hits	8
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

E2F3_MOUSE
NC score	0.006957 (rank : 105)	θ value	8.99809 (rank : 110)
Query Neighborhood Hits	119	Target Neighborhood Hits	47	Shared Neighborhood Hits	3
SwissProt Accessions	O35261, Q5T0I6	Gene names	E2f3
Domain Architecture	No domain graphic available
Description	Transcription factor E2F3 (E2F-3).

NKTR_HUMAN
NC score	0.006627 (rank : 106)	θ value	6.88961 (rank : 102)
Query Neighborhood Hits	119	Target Neighborhood Hits	658	Shared Neighborhood Hits	10
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

RBP2_MOUSE
NC score	0.006376 (rank : 107)	θ value	6.88961 (rank : 104)
Query Neighborhood Hits	119	Target Neighborhood Hits	232	Shared Neighborhood Hits	5
SwissProt Accessions	Q9ERU9, Q61992, Q8C9K9	Gene names	Ranbp2
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2 (RanBP2).

DDEF2_HUMAN
NC score	0.006171 (rank : 108)	θ value	4.03905 (rank : 73)
Query Neighborhood Hits	119	Target Neighborhood Hits	599	Shared Neighborhood Hits	5
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

HXA4_MOUSE
NC score	0.005481 (rank : 109)	θ value	1.38821 (rank : 49)
Query Neighborhood Hits	119	Target Neighborhood Hits	379	Shared Neighborhood Hits	4
SwissProt Accessions	P06798, Q61684, Q64388, Q8BPE6	Gene names	Hoxa4, Hox-1.4, Hoxa-4
Domain Architecture
Description	Homeobox protein Hox-A4 (Hox-1.4) (Homeobox protein MH-3).

TNK1_MOUSE
NC score	0.004581 (rank : 110)	θ value	8.99809 (rank : 117)
Query Neighborhood Hits	119	Target Neighborhood Hits	806	Shared Neighborhood Hits	8
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

PTPRR_HUMAN
NC score	0.004537 (rank : 111)	θ value	5.27518 (rank : 91)
Query Neighborhood Hits	119	Target Neighborhood Hits	77	Shared Neighborhood Hits	2
SwissProt Accessions	Q15256, O00342, Q92682, Q9UE65	Gene names	PTPRR, ECPTP
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase).

BAI1_HUMAN
NC score	0.004163 (rank : 112)	θ value	5.27518 (rank : 80)
Query Neighborhood Hits	119	Target Neighborhood Hits	375	Shared Neighborhood Hits	9
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

NETR_HUMAN
NC score	0.004045 (rank : 113)	θ value	1.81305 (rank : 54)
Query Neighborhood Hits	119	Target Neighborhood Hits	218	Shared Neighborhood Hits	3
SwissProt Accessions	P56730, Q9UP16	Gene names	PRSS12
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Leydin).

FAK1_MOUSE
NC score	0.002603 (rank : 114)	θ value	4.03905 (rank : 74)
Query Neighborhood Hits	119	Target Neighborhood Hits	850	Shared Neighborhood Hits	7
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

M3K1_MOUSE
NC score	0.002146 (rank : 115)	θ value	1.81305 (rank : 53)
Query Neighborhood Hits	119	Target Neighborhood Hits	952	Shared Neighborhood Hits	9
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

SPEG_HUMAN
NC score	0.000742 (rank : 116)	θ value	8.99809 (rank : 116)
Query Neighborhood Hits	119	Target Neighborhood Hits	1762	Shared Neighborhood Hits	27
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

HIC1_MOUSE
NC score	0.000446 (rank : 117)	θ value	3.0926 (rank : 67)
Query Neighborhood Hits	119	Target Neighborhood Hits	863	Shared Neighborhood Hits	7
SwissProt Accessions	Q9R1Y5, Q9R1Y6, Q9R2B0	Gene names	Hic1
Domain Architecture
Description	Hypermethylated in cancer 1 protein (Hic-1).

HIC1_HUMAN
NC score	0.000107 (rank : 118)	θ value	4.03905 (rank : 76)
Query Neighborhood Hits	119	Target Neighborhood Hits	838	Shared Neighborhood Hits	7
SwissProt Accessions	Q14526	Gene names	HIC1, ZBTB29
Domain Architecture
Description	Hypermethylated in cancer 1 protein (Hic-1) (Zinc finger and BTB domain-containing protein 29).

SALL3_HUMAN
NC score	0.000005 (rank : 119)	θ value	8.99809 (rank : 115)
Query Neighborhood Hits	119	Target Neighborhood Hits	1066	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BXA9, Q9UGH1	Gene names	SALL3
Domain Architecture	No domain graphic available
Description	Sal-like protein 3 (Zinc finger protein SALL3) (hSALL3).

ZN692_MOUSE
NC score	-0.000348 (rank : 120)	θ value	5.27518 (rank : 96)
Query Neighborhood Hits	119	Target Neighborhood Hits	751	Shared Neighborhood Hits	7
SwissProt Accessions	Q3U381	Gene names	Znf692, Zfp692
Domain Architecture	No domain graphic available
Description	Zinc finger protein 692.