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Network neighborhood for query Sequence : SPEG_HUMAN

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SPEG_HUMAN
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SPEG_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1762	Shared Neighborhood Hits	1762
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SPEG_MOUSE
θ value	0 (rank : 2)	NC score	0.986780 (rank : 2)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1959	Shared Neighborhood Hits	1436
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

OBSCN_HUMAN
θ value	1.18001e-100 (rank : 3)	NC score	0.943865 (rank : 5)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1931	Shared Neighborhood Hits	1244
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

DAPK2_HUMAN
θ value	3.48141e-52 (rank : 4)	NC score	0.888155 (rank : 8)
Query Neighborhood Hits	1762	Target Neighborhood Hits	832	Shared Neighborhood Hits	814
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK2_MOUSE
θ value	5.93839e-52 (rank : 5)	NC score	0.887650 (rank : 9)
Query Neighborhood Hits	1762	Target Neighborhood Hits	834	Shared Neighborhood Hits	817
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

TITIN_HUMAN
θ value	7.75577e-52 (rank : 6)	NC score	0.889460 (rank : 7)
Query Neighborhood Hits	1762	Target Neighborhood Hits	2923	Shared Neighborhood Hits	1282
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

DAPK3_MOUSE
θ value	1.72781e-51 (rank : 7)	NC score	0.886752 (rank : 11)
Query Neighborhood Hits	1762	Target Neighborhood Hits	843	Shared Neighborhood Hits	813
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

MYLK_HUMAN
θ value	3.84914e-51 (rank : 8)	NC score	0.954093 (rank : 3)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1328	Shared Neighborhood Hits	1090
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

MYLK_MOUSE
θ value	5.02714e-51 (rank : 9)	NC score	0.953467 (rank : 4)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1489	Shared Neighborhood Hits	1151
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

DAPK1_HUMAN
θ value	3.2585e-50 (rank : 10)	NC score	0.800276 (rank : 465)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1130	Shared Neighborhood Hits	839
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DAPK1_MOUSE
θ value	5.55816e-50 (rank : 11)	NC score	0.796112 (rank : 477)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1138	Shared Neighborhood Hits	840
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DAPK3_HUMAN
θ value	9.81109e-47 (rank : 12)	NC score	0.885151 (rank : 14)
Query Neighborhood Hits	1762	Target Neighborhood Hits	945	Shared Neighborhood Hits	816
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

TRIO_HUMAN
θ value	3.15612e-45 (rank : 13)	NC score	0.863352 (rank : 103)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1580	Shared Neighborhood Hits	1060
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

MYLK2_HUMAN
θ value	2.26182e-43 (rank : 14)	NC score	0.884650 (rank : 15)
Query Neighborhood Hits	1762	Target Neighborhood Hits	920	Shared Neighborhood Hits	852
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

ST17A_HUMAN
θ value	3.26607e-42 (rank : 15)	NC score	0.886986 (rank : 10)
Query Neighborhood Hits	1762	Target Neighborhood Hits	843	Shared Neighborhood Hits	815
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

ST17B_MOUSE
θ value	7.27602e-42 (rank : 16)	NC score	0.886453 (rank : 12)
Query Neighborhood Hits	1762	Target Neighborhood Hits	838	Shared Neighborhood Hits	820
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

DUET_HUMAN
θ value	9.50281e-42 (rank : 17)	NC score	0.898241 (rank : 6)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1220	Shared Neighborhood Hits	1005
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

ST17B_HUMAN
θ value	1.2411e-41 (rank : 18)	NC score	0.886255 (rank : 13)
Query Neighborhood Hits	1762	Target Neighborhood Hits	833	Shared Neighborhood Hits	816
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

OBSL1_HUMAN
θ value	2.34062e-40 (rank : 19)	NC score	0.421978 (rank : 831)
Query Neighborhood Hits	1762	Target Neighborhood Hits	354	Shared Neighborhood Hits	270
SwissProt Accessions	O75147, Q96IW3	Gene names	OBSL1, KIAA0657
Domain Architecture	No domain graphic available
Description	Obscurin-like protein 1 precursor.

HMCN1_HUMAN
θ value	1.16164e-39 (rank : 20)	NC score	0.288036 (rank : 952)
Query Neighborhood Hits	1762	Target Neighborhood Hits	983	Shared Neighborhood Hits	334
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

PGBM_HUMAN
θ value	9.20422e-37 (rank : 21)	NC score	0.287597 (rank : 954)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1113	Shared Neighborhood Hits	359
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

KCC1D_HUMAN
θ value	1.46948e-34 (rank : 22)	NC score	0.878925 (rank : 21)
Query Neighborhood Hits	1762	Target Neighborhood Hits	846	Shared Neighborhood Hits	825
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

KCC1D_MOUSE
θ value	1.46948e-34 (rank : 23)	NC score	0.879052 (rank : 19)
Query Neighborhood Hits	1762	Target Neighborhood Hits	847	Shared Neighborhood Hits	826
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

KPSH1_HUMAN
θ value	9.52487e-34 (rank : 24)	NC score	0.879590 (rank : 16)
Query Neighborhood Hits	1762	Target Neighborhood Hits	842	Shared Neighborhood Hits	820
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KCC2G_HUMAN
θ value	1.24399e-33 (rank : 25)	NC score	0.877902 (rank : 30)
Query Neighborhood Hits	1762	Target Neighborhood Hits	841	Shared Neighborhood Hits	814
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2G_MOUSE
θ value	1.24399e-33 (rank : 26)	NC score	0.877937 (rank : 29)
Query Neighborhood Hits	1762	Target Neighborhood Hits	838	Shared Neighborhood Hits	815
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2D_HUMAN
θ value	2.12192e-33 (rank : 27)	NC score	0.876762 (rank : 33)
Query Neighborhood Hits	1762	Target Neighborhood Hits	830	Shared Neighborhood Hits	811
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

KPSH1_MOUSE
θ value	2.12192e-33 (rank : 28)	NC score	0.879438 (rank : 17)
Query Neighborhood Hits	1762	Target Neighborhood Hits	839	Shared Neighborhood Hits	820
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KCC2A_HUMAN
θ value	3.61944e-33 (rank : 29)	NC score	0.875890 (rank : 34)
Query Neighborhood Hits	1762	Target Neighborhood Hits	830	Shared Neighborhood Hits	811
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KCC2A_MOUSE
θ value	6.17384e-33 (rank : 30)	NC score	0.875704 (rank : 36)
Query Neighborhood Hits	1762	Target Neighborhood Hits	829	Shared Neighborhood Hits	809
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KCC2B_HUMAN
θ value	1.0531e-32 (rank : 31)	NC score	0.875829 (rank : 35)
Query Neighborhood Hits	1762	Target Neighborhood Hits	866	Shared Neighborhood Hits	823
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

KCC2B_MOUSE
θ value	1.0531e-32 (rank : 32)	NC score	0.874120 (rank : 38)
Query Neighborhood Hits	1762	Target Neighborhood Hits	841	Shared Neighborhood Hits	810
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

ROBO2_MOUSE
θ value	4.42448e-31 (rank : 33)	NC score	0.404279 (rank : 843)
Query Neighborhood Hits	1762	Target Neighborhood Hits	504	Shared Neighborhood Hits	331
SwissProt Accessions	Q7TPD3, Q8BJ59	Gene names	Robo2, Kiaa1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

KCC1B_MOUSE
θ value	7.54701e-31 (rank : 34)	NC score	0.878806 (rank : 22)
Query Neighborhood Hits	1762	Target Neighborhood Hits	842	Shared Neighborhood Hits	823
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

ROBO2_HUMAN
θ value	7.54701e-31 (rank : 35)	NC score	0.404414 (rank : 842)
Query Neighborhood Hits	1762	Target Neighborhood Hits	479	Shared Neighborhood Hits	323
SwissProt Accessions	Q9HCK4, O43608	Gene names	ROBO2, KIAA1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

KCC1A_HUMAN
θ value	9.8567e-31 (rank : 36)	NC score	0.878221 (rank : 26)
Query Neighborhood Hits	1762	Target Neighborhood Hits	846	Shared Neighborhood Hits	824
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1A_MOUSE
θ value	1.28732e-30 (rank : 37)	NC score	0.878278 (rank : 25)
Query Neighborhood Hits	1762	Target Neighborhood Hits	845	Shared Neighborhood Hits	824
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC4_MOUSE
θ value	1.6813e-30 (rank : 38)	NC score	0.878162 (rank : 27)
Query Neighborhood Hits	1762	Target Neighborhood Hits	899	Shared Neighborhood Hits	828
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KCC4_HUMAN
θ value	2.86786e-30 (rank : 39)	NC score	0.878410 (rank : 24)
Query Neighborhood Hits	1762	Target Neighborhood Hits	841	Shared Neighborhood Hits	819
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KCC1B_HUMAN
θ value	2.42779e-29 (rank : 40)	NC score	0.878610 (rank : 23)
Query Neighborhood Hits	1762	Target Neighborhood Hits	842	Shared Neighborhood Hits	823
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

KCC1G_MOUSE
θ value	2.42779e-29 (rank : 41)	NC score	0.876976 (rank : 31)
Query Neighborhood Hits	1762	Target Neighborhood Hits	851	Shared Neighborhood Hits	827
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KPSH2_HUMAN
θ value	2.42779e-29 (rank : 42)	NC score	0.879117 (rank : 18)
Query Neighborhood Hits	1762	Target Neighborhood Hits	822	Shared Neighborhood Hits	808
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

KS6A6_HUMAN
θ value	3.17079e-29 (rank : 43)	NC score	0.859969 (rank : 130)
Query Neighborhood Hits	1762	Target Neighborhood Hits	853	Shared Neighborhood Hits	826
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

KS6A2_HUMAN
θ value	4.14116e-29 (rank : 44)	NC score	0.860185 (rank : 128)
Query Neighborhood Hits	1762	Target Neighborhood Hits	857	Shared Neighborhood Hits	827
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

KCC1G_HUMAN
θ value	7.06379e-29 (rank : 45)	NC score	0.876802 (rank : 32)
Query Neighborhood Hits	1762	Target Neighborhood Hits	850	Shared Neighborhood Hits	825
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KS6A2_MOUSE
θ value	1.2049e-28 (rank : 46)	NC score	0.860587 (rank : 123)
Query Neighborhood Hits	1762	Target Neighborhood Hits	858	Shared Neighborhood Hits	830
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

PGBM_MOUSE
θ value	1.57365e-28 (rank : 47)	NC score	0.278440 (rank : 966)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1073	Shared Neighborhood Hits	338
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

ROBO1_HUMAN
θ value	2.68423e-28 (rank : 48)	NC score	0.406174 (rank : 838)
Query Neighborhood Hits	1762	Target Neighborhood Hits	529	Shared Neighborhood Hits	332
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

KS6A3_HUMAN
θ value	3.50572e-28 (rank : 49)	NC score	0.858736 (rank : 137)
Query Neighborhood Hits	1762	Target Neighborhood Hits	859	Shared Neighborhood Hits	829
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_MOUSE
θ value	3.50572e-28 (rank : 50)	NC score	0.858746 (rank : 136)
Query Neighborhood Hits	1762	Target Neighborhood Hits	860	Shared Neighborhood Hits	829
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A1_MOUSE
θ value	5.97985e-28 (rank : 51)	NC score	0.860328 (rank : 127)
Query Neighborhood Hits	1762	Target Neighborhood Hits	850	Shared Neighborhood Hits	828
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

ROBO1_MOUSE
θ value	5.97985e-28 (rank : 52)	NC score	0.406209 (rank : 837)
Query Neighborhood Hits	1762	Target Neighborhood Hits	559	Shared Neighborhood Hits	353
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

DCAK1_HUMAN
θ value	7.80994e-28 (rank : 53)	NC score	0.865487 (rank : 86)
Query Neighborhood Hits	1762	Target Neighborhood Hits	877	Shared Neighborhood Hits	833
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

CSKP_HUMAN
θ value	1.73987e-27 (rank : 54)	NC score	0.827480 (rank : 349)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1022	Shared Neighborhood Hits	813
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

KS6A1_HUMAN
θ value	1.73987e-27 (rank : 55)	NC score	0.859876 (rank : 131)
Query Neighborhood Hits	1762	Target Neighborhood Hits	854	Shared Neighborhood Hits	829
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

PLK3_MOUSE
θ value	2.96777e-27 (rank : 56)	NC score	0.869364 (rank : 58)
Query Neighborhood Hits	1762	Target Neighborhood Hits	863	Shared Neighborhood Hits	832
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

CSKP_MOUSE
θ value	3.87602e-27 (rank : 57)	NC score	0.829742 (rank : 334)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1027	Shared Neighborhood Hits	813
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

DCAK3_MOUSE
θ value	5.06226e-27 (rank : 58)	NC score	0.878074 (rank : 28)
Query Neighborhood Hits	1762	Target Neighborhood Hits	922	Shared Neighborhood Hits	838
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

CNTN4_HUMAN
θ value	1.12775e-26 (rank : 59)	NC score	0.387774 (rank : 867)
Query Neighborhood Hits	1762	Target Neighborhood Hits	449	Shared Neighborhood Hits	313
SwissProt Accessions	Q8IWV2, Q8IX14, Q8TC35	Gene names	CNTN4
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

DCAK1_MOUSE
θ value	1.12775e-26 (rank : 60)	NC score	0.865599 (rank : 84)
Query Neighborhood Hits	1762	Target Neighborhood Hits	867	Shared Neighborhood Hits	828
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DCAK2_HUMAN
θ value	1.12775e-26 (rank : 61)	NC score	0.864853 (rank : 90)
Query Neighborhood Hits	1762	Target Neighborhood Hits	862	Shared Neighborhood Hits	820
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

DCAK3_HUMAN
θ value	1.92365e-26 (rank : 62)	NC score	0.879034 (rank : 20)
Query Neighborhood Hits	1762	Target Neighborhood Hits	888	Shared Neighborhood Hits	835
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

DCAK2_MOUSE
θ value	3.28125e-26 (rank : 63)	NC score	0.865272 (rank : 87)
Query Neighborhood Hits	1762	Target Neighborhood Hits	858	Shared Neighborhood Hits	820
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

SN1L1_MOUSE
θ value	4.28545e-26 (rank : 64)	NC score	0.864791 (rank : 91)
Query Neighborhood Hits	1762	Target Neighborhood Hits	895	Shared Neighborhood Hits	839
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

CNTN4_MOUSE
θ value	9.54697e-26 (rank : 65)	NC score	0.388345 (rank : 866)
Query Neighborhood Hits	1762	Target Neighborhood Hits	445	Shared Neighborhood Hits	312
SwissProt Accessions	Q69Z26, Q8BRT6, Q8CBD3	Gene names	Cntn4, Kiaa3024
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

PHKG2_HUMAN
θ value	9.54697e-26 (rank : 66)	NC score	0.873282 (rank : 41)
Query Neighborhood Hits	1762	Target Neighborhood Hits	839	Shared Neighborhood Hits	821
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

MELK_MOUSE
θ value	1.62847e-25 (rank : 67)	NC score	0.868598 (rank : 65)
Query Neighborhood Hits	1762	Target Neighborhood Hits	860	Shared Neighborhood Hits	824
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

PLK3_HUMAN
θ value	1.62847e-25 (rank : 68)	NC score	0.869092 (rank : 59)
Query Neighborhood Hits	1762	Target Neighborhood Hits	865	Shared Neighborhood Hits	830
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

DCC_HUMAN
θ value	2.12685e-25 (rank : 69)	NC score	0.392243 (rank : 853)
Query Neighborhood Hits	1762	Target Neighborhood Hits	583	Shared Neighborhood Hits	370
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

DCC_MOUSE
θ value	2.12685e-25 (rank : 70)	NC score	0.391344 (rank : 856)
Query Neighborhood Hits	1762	Target Neighborhood Hits	896	Shared Neighborhood Hits	473
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

PHKG1_HUMAN
θ value	2.12685e-25 (rank : 71)	NC score	0.870086 (rank : 54)
Query Neighborhood Hits	1762	Target Neighborhood Hits	838	Shared Neighborhood Hits	819
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

CHK2_MOUSE
θ value	2.77775e-25 (rank : 72)	NC score	0.873825 (rank : 39)
Query Neighborhood Hits	1762	Target Neighborhood Hits	860	Shared Neighborhood Hits	819
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

PLK4_MOUSE
θ value	3.62785e-25 (rank : 73)	NC score	0.872125 (rank : 45)
Query Neighborhood Hits	1762	Target Neighborhood Hits	879	Shared Neighborhood Hits	832
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PHKG2_MOUSE
θ value	4.73814e-25 (rank : 74)	NC score	0.873424 (rank : 40)
Query Neighborhood Hits	1762	Target Neighborhood Hits	841	Shared Neighborhood Hits	823
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

STK33_HUMAN
θ value	4.73814e-25 (rank : 75)	NC score	0.874439 (rank : 37)
Query Neighborhood Hits	1762	Target Neighborhood Hits	879	Shared Neighborhood Hits	823
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

ROBO3_HUMAN
θ value	8.08199e-25 (rank : 76)	NC score	0.405148 (rank : 840)
Query Neighborhood Hits	1762	Target Neighborhood Hits	570	Shared Neighborhood Hits	375
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

AKT3_HUMAN
θ value	1.37858e-24 (rank : 77)	NC score	0.852275 (rank : 187)
Query Neighborhood Hits	1762	Target Neighborhood Hits	872	Shared Neighborhood Hits	820
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
θ value	1.37858e-24 (rank : 78)	NC score	0.852259 (rank : 188)
Query Neighborhood Hits	1762	Target Neighborhood Hits	872	Shared Neighborhood Hits	820
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

MELK_HUMAN
θ value	1.37858e-24 (rank : 79)	NC score	0.868429 (rank : 67)
Query Neighborhood Hits	1762	Target Neighborhood Hits	847	Shared Neighborhood Hits	820
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

PLK4_HUMAN
θ value	1.37858e-24 (rank : 80)	NC score	0.872267 (rank : 44)
Query Neighborhood Hits	1762	Target Neighborhood Hits	884	Shared Neighborhood Hits	831
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

SN1L1_HUMAN
θ value	1.80048e-24 (rank : 81)	NC score	0.863927 (rank : 96)
Query Neighborhood Hits	1762	Target Neighborhood Hits	911	Shared Neighborhood Hits	839
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

AURKB_HUMAN
θ value	3.07116e-24 (rank : 82)	NC score	0.870880 (rank : 51)
Query Neighborhood Hits	1762	Target Neighborhood Hits	847	Shared Neighborhood Hits	826
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

AURKB_MOUSE
θ value	3.07116e-24 (rank : 83)	NC score	0.871814 (rank : 47)
Query Neighborhood Hits	1762	Target Neighborhood Hits	858	Shared Neighborhood Hits	827
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

STK6_HUMAN
θ value	5.23862e-24 (rank : 84)	NC score	0.871846 (rank : 46)
Query Neighborhood Hits	1762	Target Neighborhood Hits	916	Shared Neighborhood Hits	846
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

CNTN3_MOUSE
θ value	6.84181e-24 (rank : 85)	NC score	0.381086 (rank : 884)
Query Neighborhood Hits	1762	Target Neighborhood Hits	447	Shared Neighborhood Hits	317
SwissProt Accessions	Q07409	Gene names	Cntn3, Pang, Pcs
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

MARK2_HUMAN
θ value	6.84181e-24 (rank : 86)	NC score	0.861791 (rank : 116)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1056	Shared Neighborhood Hits	890
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

AKT2_MOUSE
θ value	8.93572e-24 (rank : 87)	NC score	0.850884 (rank : 195)
Query Neighborhood Hits	1762	Target Neighborhood Hits	875	Shared Neighborhood Hits	816
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

BRSK1_HUMAN
θ value	8.93572e-24 (rank : 88)	NC score	0.870091 (rank : 53)
Query Neighborhood Hits	1762	Target Neighborhood Hits	942	Shared Neighborhood Hits	866
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

PLK2_HUMAN
θ value	1.16704e-23 (rank : 89)	NC score	0.867565 (rank : 72)
Query Neighborhood Hits	1762	Target Neighborhood Hits	854	Shared Neighborhood Hits	828
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK2_MOUSE
θ value	1.16704e-23 (rank : 90)	NC score	0.867253 (rank : 73)
Query Neighborhood Hits	1762	Target Neighborhood Hits	849	Shared Neighborhood Hits	827
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

CHK2_HUMAN
θ value	1.5242e-23 (rank : 91)	NC score	0.872697 (rank : 42)
Query Neighborhood Hits	1762	Target Neighborhood Hits	859	Shared Neighborhood Hits	820
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

KPCD3_MOUSE
θ value	1.5242e-23 (rank : 92)	NC score	0.862619 (rank : 109)
Query Neighborhood Hits	1762	Target Neighborhood Hits	901	Shared Neighborhood Hits	818
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

AKT2_HUMAN
θ value	1.99067e-23 (rank : 93)	NC score	0.851377 (rank : 191)
Query Neighborhood Hits	1762	Target Neighborhood Hits	878	Shared Neighborhood Hits	816
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

MARK4_HUMAN
θ value	1.99067e-23 (rank : 94)	NC score	0.863197 (rank : 105)
Query Neighborhood Hits	1762	Target Neighborhood Hits	886	Shared Neighborhood Hits	840
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MARK4_MOUSE
θ value	1.99067e-23 (rank : 95)	NC score	0.863001 (rank : 107)
Query Neighborhood Hits	1762	Target Neighborhood Hits	898	Shared Neighborhood Hits	840
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

NUAK2_HUMAN
θ value	1.99067e-23 (rank : 96)	NC score	0.868849 (rank : 63)
Query Neighborhood Hits	1762	Target Neighborhood Hits	874	Shared Neighborhood Hits	830
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

CNTN5_HUMAN
θ value	3.39556e-23 (rank : 97)	NC score	0.390011 (rank : 862)
Query Neighborhood Hits	1762	Target Neighborhood Hits	446	Shared Neighborhood Hits	329
SwissProt Accessions	O94779, O94780	Gene names	CNTN5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2) (hNB-2).

KPCD1_HUMAN
θ value	4.43474e-23 (rank : 98)	NC score	0.864240 (rank : 94)
Query Neighborhood Hits	1762	Target Neighborhood Hits	901	Shared Neighborhood Hits	820
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

MARK2_MOUSE
θ value	4.43474e-23 (rank : 99)	NC score	0.861074 (rank : 120)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1018	Shared Neighborhood Hits	874
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

MYPN_HUMAN
θ value	4.43474e-23 (rank : 100)	NC score	0.404430 (rank : 841)
Query Neighborhood Hits	1762	Target Neighborhood Hits	418	Shared Neighborhood Hits	308
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

MYPN_MOUSE
θ value	4.43474e-23 (rank : 101)	NC score	0.401698 (rank : 845)
Query Neighborhood Hits	1762	Target Neighborhood Hits	421	Shared Neighborhood Hits	310
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

SN1L2_MOUSE
θ value	4.43474e-23 (rank : 102)	NC score	0.861316 (rank : 118)
Query Neighborhood Hits	1762	Target Neighborhood Hits	944	Shared Neighborhood Hits	866
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

STK36_HUMAN
θ value	4.43474e-23 (rank : 103)	NC score	0.866502 (rank : 79)
Query Neighborhood Hits	1762	Target Neighborhood Hits	896	Shared Neighborhood Hits	835
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

NEO1_HUMAN
θ value	5.79196e-23 (rank : 104)	NC score	0.390758 (rank : 859)
Query Neighborhood Hits	1762	Target Neighborhood Hits	530	Shared Neighborhood Hits	340
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

AKT1_HUMAN
θ value	7.56453e-23 (rank : 105)	NC score	0.847408 (rank : 215)
Query Neighborhood Hits	1762	Target Neighborhood Hits	885	Shared Neighborhood Hits	815
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

AKT1_MOUSE
θ value	7.56453e-23 (rank : 106)	NC score	0.847121 (rank : 218)
Query Neighborhood Hits	1762	Target Neighborhood Hits	878	Shared Neighborhood Hits	814
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

CNTN3_HUMAN
θ value	7.56453e-23 (rank : 107)	NC score	0.383941 (rank : 879)
Query Neighborhood Hits	1762	Target Neighborhood Hits	455	Shared Neighborhood Hits	322
SwissProt Accessions	Q9P232, Q9H039	Gene names	CNTN3, KIAA1496, PANG
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

KPCD1_MOUSE
θ value	7.56453e-23 (rank : 108)	NC score	0.863895 (rank : 97)
Query Neighborhood Hits	1762	Target Neighborhood Hits	891	Shared Neighborhood Hits	821
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

KPCD3_HUMAN
θ value	7.56453e-23 (rank : 109)	NC score	0.862149 (rank : 112)
Query Neighborhood Hits	1762	Target Neighborhood Hits	895	Shared Neighborhood Hits	819
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

K0999_HUMAN
θ value	1.29031e-22 (rank : 110)	NC score	0.861968 (rank : 113)
Query Neighborhood Hits	1762	Target Neighborhood Hits	899	Shared Neighborhood Hits	831
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

K0999_MOUSE
θ value	1.29031e-22 (rank : 111)	NC score	0.861920 (rank : 114)
Query Neighborhood Hits	1762	Target Neighborhood Hits	931	Shared Neighborhood Hits	838
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

MARK1_HUMAN
θ value	1.29031e-22 (rank : 112)	NC score	0.859856 (rank : 132)
Query Neighborhood Hits	1762	Target Neighborhood Hits	887	Shared Neighborhood Hits	829
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

NUAK1_HUMAN
θ value	1.29031e-22 (rank : 113)	NC score	0.866926 (rank : 76)
Query Neighborhood Hits	1762	Target Neighborhood Hits	874	Shared Neighborhood Hits	830
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

SN1L2_HUMAN
θ value	1.29031e-22 (rank : 114)	NC score	0.861893 (rank : 115)
Query Neighborhood Hits	1762	Target Neighborhood Hits	964	Shared Neighborhood Hits	883
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

STK6_MOUSE
θ value	1.29031e-22 (rank : 115)	NC score	0.871812 (rank : 48)
Query Neighborhood Hits	1762	Target Neighborhood Hits	886	Shared Neighborhood Hits	838
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

STK36_MOUSE
θ value	1.6852e-22 (rank : 116)	NC score	0.864423 (rank : 93)
Query Neighborhood Hits	1762	Target Neighborhood Hits	877	Shared Neighborhood Hits	832
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

BRSK2_HUMAN
θ value	2.20094e-22 (rank : 117)	NC score	0.868373 (rank : 68)
Query Neighborhood Hits	1762	Target Neighborhood Hits	897	Shared Neighborhood Hits	846
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

KS6A5_HUMAN
θ value	2.20094e-22 (rank : 118)	NC score	0.856193 (rank : 149)
Query Neighborhood Hits	1762	Target Neighborhood Hits	855	Shared Neighborhood Hits	827
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

PHKG1_MOUSE
θ value	2.20094e-22 (rank : 119)	NC score	0.869478 (rank : 57)
Query Neighborhood Hits	1762	Target Neighborhood Hits	840	Shared Neighborhood Hits	819
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

CNTN6_MOUSE
θ value	2.87452e-22 (rank : 120)	NC score	0.384021 (rank : 878)
Query Neighborhood Hits	1762	Target Neighborhood Hits	429	Shared Neighborhood Hits	307
SwissProt Accessions	Q9JMB8, Q8C6X1	Gene names	Cntn6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (mNB-3).

KS6A4_HUMAN
θ value	2.87452e-22 (rank : 121)	NC score	0.852662 (rank : 183)
Query Neighborhood Hits	1762	Target Neighborhood Hits	868	Shared Neighborhood Hits	830
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

NUAK1_MOUSE
θ value	3.75424e-22 (rank : 122)	NC score	0.866867 (rank : 77)
Query Neighborhood Hits	1762	Target Neighborhood Hits	881	Shared Neighborhood Hits	829
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

CNTN5_MOUSE
θ value	4.9032e-22 (rank : 123)	NC score	0.386478 (rank : 869)
Query Neighborhood Hits	1762	Target Neighborhood Hits	434	Shared Neighborhood Hits	326
SwissProt Accessions	P68500	Gene names	Cntn5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2).

KS6A4_MOUSE
θ value	6.40375e-22 (rank : 124)	NC score	0.852783 (rank : 181)
Query Neighborhood Hits	1762	Target Neighborhood Hits	866	Shared Neighborhood Hits	826
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

NEO1_MOUSE
θ value	6.40375e-22 (rank : 125)	NC score	0.390063 (rank : 861)
Query Neighborhood Hits	1762	Target Neighborhood Hits	523	Shared Neighborhood Hits	343
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

NUAK2_MOUSE
θ value	6.40375e-22 (rank : 126)	NC score	0.868453 (rank : 66)
Query Neighborhood Hits	1762	Target Neighborhood Hits	878	Shared Neighborhood Hits	830
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

PRKX_HUMAN
θ value	6.40375e-22 (rank : 127)	NC score	0.857017 (rank : 145)
Query Neighborhood Hits	1762	Target Neighborhood Hits	847	Shared Neighborhood Hits	823
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

CDKL1_MOUSE
θ value	8.36355e-22 (rank : 128)	NC score	0.843277 (rank : 240)
Query Neighborhood Hits	1762	Target Neighborhood Hits	829	Shared Neighborhood Hits	815
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

CDKL4_HUMAN
θ value	8.36355e-22 (rank : 129)	NC score	0.840112 (rank : 266)
Query Neighborhood Hits	1762	Target Neighborhood Hits	828	Shared Neighborhood Hits	812
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

PAK7_HUMAN
θ value	1.09232e-21 (rank : 130)	NC score	0.855912 (rank : 154)
Query Neighborhood Hits	1762	Target Neighborhood Hits	875	Shared Neighborhood Hits	829
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

PAK7_MOUSE
θ value	1.09232e-21 (rank : 131)	NC score	0.856028 (rank : 150)
Query Neighborhood Hits	1762	Target Neighborhood Hits	875	Shared Neighborhood Hits	832
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

CAMKV_HUMAN
θ value	1.42661e-21 (rank : 132)	NC score	0.854667 (rank : 160)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1084	Shared Neighborhood Hits	880
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CDKL4_MOUSE
θ value	1.42661e-21 (rank : 133)	NC score	0.842365 (rank : 247)
Query Neighborhood Hits	1762	Target Neighborhood Hits	833	Shared Neighborhood Hits	816
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

PLK1_MOUSE
θ value	1.42661e-21 (rank : 134)	NC score	0.869734 (rank : 56)
Query Neighborhood Hits	1762	Target Neighborhood Hits	849	Shared Neighborhood Hits	822
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

MARK1_MOUSE
θ value	1.86321e-21 (rank : 135)	NC score	0.859621 (rank : 133)
Query Neighborhood Hits	1762	Target Neighborhood Hits	886	Shared Neighborhood Hits	829
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

MARK3_MOUSE
θ value	1.86321e-21 (rank : 136)	NC score	0.860906 (rank : 121)
Query Neighborhood Hits	1762	Target Neighborhood Hits	919	Shared Neighborhood Hits	845
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

PAK3_HUMAN
θ value	1.86321e-21 (rank : 137)	NC score	0.853573 (rank : 170)
Query Neighborhood Hits	1762	Target Neighborhood Hits	887	Shared Neighborhood Hits	833
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PAK1_HUMAN
θ value	2.43343e-21 (rank : 138)	NC score	0.853869 (rank : 165)
Query Neighborhood Hits	1762	Target Neighborhood Hits	873	Shared Neighborhood Hits	836
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

PLK1_HUMAN
θ value	3.17815e-21 (rank : 139)	NC score	0.869081 (rank : 60)
Query Neighborhood Hits	1762	Target Neighborhood Hits	849	Shared Neighborhood Hits	823
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

CAMKV_MOUSE
θ value	4.15078e-21 (rank : 140)	NC score	0.856832 (rank : 147)
Query Neighborhood Hits	1762	Target Neighborhood Hits	848	Shared Neighborhood Hits	802
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CDKL1_HUMAN
θ value	4.15078e-21 (rank : 141)	NC score	0.842542 (rank : 245)
Query Neighborhood Hits	1762	Target Neighborhood Hits	830	Shared Neighborhood Hits	815
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

CNTN6_HUMAN
θ value	4.15078e-21 (rank : 142)	NC score	0.382200 (rank : 880)
Query Neighborhood Hits	1762	Target Neighborhood Hits	422	Shared Neighborhood Hits	307
SwissProt Accessions	Q9UQ52	Gene names	CNTN6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (hNB-3).

NEK3_MOUSE
θ value	4.15078e-21 (rank : 143)	NC score	0.860340 (rank : 126)
Query Neighborhood Hits	1762	Target Neighborhood Hits	854	Shared Neighborhood Hits	830
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

PAK2_HUMAN
θ value	4.15078e-21 (rank : 144)	NC score	0.855819 (rank : 155)
Query Neighborhood Hits	1762	Target Neighborhood Hits	862	Shared Neighborhood Hits	832
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

PAK2_MOUSE
θ value	4.15078e-21 (rank : 145)	NC score	0.855772 (rank : 156)
Query Neighborhood Hits	1762	Target Neighborhood Hits	858	Shared Neighborhood Hits	831
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

KGP1A_HUMAN
θ value	5.42112e-21 (rank : 146)	NC score	0.843127 (rank : 241)
Query Neighborhood Hits	1762	Target Neighborhood Hits	901	Shared Neighborhood Hits	821
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_HUMAN
θ value	5.42112e-21 (rank : 147)	NC score	0.842673 (rank : 244)
Query Neighborhood Hits	1762	Target Neighborhood Hits	921	Shared Neighborhood Hits	823
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_MOUSE
θ value	5.42112e-21 (rank : 148)	NC score	0.842736 (rank : 243)
Query Neighborhood Hits	1762	Target Neighborhood Hits	922	Shared Neighborhood Hits	823
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KPCD2_HUMAN
θ value	5.42112e-21 (rank : 149)	NC score	0.864933 (rank : 89)
Query Neighborhood Hits	1762	Target Neighborhood Hits	910	Shared Neighborhood Hits	823
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

SNRK_HUMAN
θ value	5.42112e-21 (rank : 150)	NC score	0.869825 (rank : 55)
Query Neighborhood Hits	1762	Target Neighborhood Hits	855	Shared Neighborhood Hits	812
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

HUNK_MOUSE
θ value	7.0802e-21 (rank : 151)	NC score	0.869042 (rank : 61)
Query Neighborhood Hits	1762	Target Neighborhood Hits	874	Shared Neighborhood Hits	830
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

L1CAM_HUMAN
θ value	7.0802e-21 (rank : 152)	NC score	0.385447 (rank : 871)
Query Neighborhood Hits	1762	Target Neighborhood Hits	457	Shared Neighborhood Hits	324
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

PAK1_MOUSE
θ value	9.24701e-21 (rank : 153)	NC score	0.853414 (rank : 171)
Query Neighborhood Hits	1762	Target Neighborhood Hits	878	Shared Neighborhood Hits	841
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

PRKX_MOUSE
θ value	9.24701e-21 (rank : 154)	NC score	0.856949 (rank : 146)
Query Neighborhood Hits	1762	Target Neighborhood Hits	846	Shared Neighborhood Hits	824
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

PRKY_HUMAN
θ value	9.24701e-21 (rank : 155)	NC score	0.862312 (rank : 111)
Query Neighborhood Hits	1762	Target Neighborhood Hits	844	Shared Neighborhood Hits	822
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

PUNC_HUMAN
θ value	9.24701e-21 (rank : 156)	NC score	0.399457 (rank : 846)
Query Neighborhood Hits	1762	Target Neighborhood Hits	449	Shared Neighborhood Hits	302
SwissProt Accessions	Q8IVU1, O95215	Gene names	PUNC
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

AAPK2_HUMAN
θ value	1.2077e-20 (rank : 157)	NC score	0.865176 (rank : 88)
Query Neighborhood Hits	1762	Target Neighborhood Hits	843	Shared Neighborhood Hits	826
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

KAPCG_HUMAN
θ value	1.2077e-20 (rank : 158)	NC score	0.858171 (rank : 141)
Query Neighborhood Hits	1762	Target Neighborhood Hits	845	Shared Neighborhood Hits	826
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

PAK3_MOUSE
θ value	1.2077e-20 (rank : 159)	NC score	0.853637 (rank : 169)
Query Neighborhood Hits	1762	Target Neighborhood Hits	874	Shared Neighborhood Hits	829
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

HUNK_HUMAN
θ value	1.5773e-20 (rank : 160)	NC score	0.868762 (rank : 64)
Query Neighborhood Hits	1762	Target Neighborhood Hits	884	Shared Neighborhood Hits	830
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

ROBO3_MOUSE
θ value	1.5773e-20 (rank : 161)	NC score	0.401808 (rank : 844)
Query Neighborhood Hits	1762	Target Neighborhood Hits	524	Shared Neighborhood Hits	360
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

AURKC_MOUSE
θ value	2.06002e-20 (rank : 162)	NC score	0.872617 (rank : 43)
Query Neighborhood Hits	1762	Target Neighborhood Hits	844	Shared Neighborhood Hits	827
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

L1CAM_MOUSE
θ value	2.06002e-20 (rank : 163)	NC score	0.384075 (rank : 877)
Query Neighborhood Hits	1762	Target Neighborhood Hits	457	Shared Neighborhood Hits	322
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

MYPC1_HUMAN
θ value	2.69047e-20 (rank : 164)	NC score	0.363451 (rank : 896)
Query Neighborhood Hits	1762	Target Neighborhood Hits	303	Shared Neighborhood Hits	259
SwissProt Accessions	Q00872, Q15497	Gene names	MYBPC1, MYBPCS
Domain Architecture
Description	Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform).

AURKC_HUMAN
θ value	3.51386e-20 (rank : 165)	NC score	0.871102 (rank : 50)
Query Neighborhood Hits	1762	Target Neighborhood Hits	847	Shared Neighborhood Hits	827
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

CNTN1_MOUSE
θ value	3.51386e-20 (rank : 166)	NC score	0.381557 (rank : 883)
Query Neighborhood Hits	1762	Target Neighborhood Hits	422	Shared Neighborhood Hits	312
SwissProt Accessions	P12960, Q6NXV7, Q8BR42, Q8C6A0	Gene names	Cntn1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3).

MKNK1_MOUSE
θ value	3.51386e-20 (rank : 167)	NC score	0.857508 (rank : 142)
Query Neighborhood Hits	1762	Target Neighborhood Hits	811	Shared Neighborhood Hits	794
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

NEK3_HUMAN
θ value	3.51386e-20 (rank : 168)	NC score	0.858361 (rank : 139)
Query Neighborhood Hits	1762	Target Neighborhood Hits	865	Shared Neighborhood Hits	829
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

NFASC_HUMAN
θ value	3.51386e-20 (rank : 169)	NC score	0.390296 (rank : 860)
Query Neighborhood Hits	1762	Target Neighborhood Hits	497	Shared Neighborhood Hits	349
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

SNRK_MOUSE
θ value	4.58923e-20 (rank : 170)	NC score	0.868939 (rank : 62)
Query Neighborhood Hits	1762	Target Neighborhood Hits	849	Shared Neighborhood Hits	810
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

BOC_MOUSE
θ value	5.99374e-20 (rank : 171)	NC score	0.394622 (rank : 851)
Query Neighborhood Hits	1762	Target Neighborhood Hits	433	Shared Neighborhood Hits	312
SwissProt Accessions	Q6AZB0, Q6KAM5, Q6P5H3, Q7TMJ3, Q8CE73, Q8CE91, Q8R377, Q923W7	Gene names	Boc
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

DSCL1_HUMAN
θ value	1.02238e-19 (rank : 172)	NC score	0.393912 (rank : 852)
Query Neighborhood Hits	1762	Target Neighborhood Hits	589	Shared Neighborhood Hits	379
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

PDPK1_HUMAN
θ value	1.02238e-19 (rank : 173)	NC score	0.864229 (rank : 95)
Query Neighborhood Hits	1762	Target Neighborhood Hits	851	Shared Neighborhood Hits	828
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

PKN3_MOUSE
θ value	1.02238e-19 (rank : 174)	NC score	0.840176 (rank : 265)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1009	Shared Neighborhood Hits	851
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PUNC_MOUSE
θ value	1.02238e-19 (rank : 175)	NC score	0.399405 (rank : 847)
Query Neighborhood Hits	1762	Target Neighborhood Hits	501	Shared Neighborhood Hits	325
SwissProt Accessions	Q8BQC3, O70246, Q792T2, Q9Z2S6	Gene names	Punc
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

ULK3_MOUSE
θ value	1.02238e-19 (rank : 176)	NC score	0.871676 (rank : 49)
Query Neighborhood Hits	1762	Target Neighborhood Hits	872	Shared Neighborhood Hits	824
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

MYPC2_HUMAN
θ value	1.33526e-19 (rank : 177)	NC score	0.356251 (rank : 899)
Query Neighborhood Hits	1762	Target Neighborhood Hits	316	Shared Neighborhood Hits	264
SwissProt Accessions	Q14324	Gene names	MYBPC2, MYBPCF
Domain Architecture
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

NFASC_MOUSE
θ value	1.74391e-19 (rank : 178)	NC score	0.391841 (rank : 855)
Query Neighborhood Hits	1762	Target Neighborhood Hits	475	Shared Neighborhood Hits	339
SwissProt Accessions	Q810U3	Gene names	Nfasc
Domain Architecture
Description	Neurofascin precursor.

PDPK1_MOUSE
θ value	1.74391e-19 (rank : 179)	NC score	0.863847 (rank : 99)
Query Neighborhood Hits	1762	Target Neighborhood Hits	852	Shared Neighborhood Hits	827
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

ST38L_HUMAN
θ value	1.74391e-19 (rank : 180)	NC score	0.830605 (rank : 329)
Query Neighborhood Hits	1762	Target Neighborhood Hits	824	Shared Neighborhood Hits	790
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

CNTN1_HUMAN
θ value	2.27762e-19 (rank : 181)	NC score	0.380997 (rank : 885)
Query Neighborhood Hits	1762	Target Neighborhood Hits	431	Shared Neighborhood Hits	314
SwissProt Accessions	Q12860, Q12861, Q14030, Q8N466	Gene names	CNTN1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3) (Glycoprotein gp135).

KPCG_HUMAN
θ value	2.27762e-19 (rank : 182)	NC score	0.812083 (rank : 431)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1126	Shared Neighborhood Hits	821
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCG_MOUSE
θ value	2.27762e-19 (rank : 183)	NC score	0.812334 (rank : 427)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1123	Shared Neighborhood Hits	821
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

AAPK1_HUMAN
θ value	2.97466e-19 (rank : 184)	NC score	0.865659 (rank : 83)
Query Neighborhood Hits	1762	Target Neighborhood Hits	842	Shared Neighborhood Hits	828
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK1_MOUSE
θ value	2.97466e-19 (rank : 185)	NC score	0.865499 (rank : 85)
Query Neighborhood Hits	1762	Target Neighborhood Hits	843	Shared Neighborhood Hits	828
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

KKCC1_MOUSE
θ value	2.97466e-19 (rank : 186)	NC score	0.867881 (rank : 70)
Query Neighborhood Hits	1762	Target Neighborhood Hits	866	Shared Neighborhood Hits	833
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KS6A5_MOUSE
θ value	2.97466e-19 (rank : 187)	NC score	0.849427 (rank : 205)
Query Neighborhood Hits	1762	Target Neighborhood Hits	854	Shared Neighborhood Hits	824
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

STK4_MOUSE
θ value	3.88503e-19 (rank : 188)	NC score	0.840958 (rank : 257)
Query Neighborhood Hits	1762	Target Neighborhood Hits	873	Shared Neighborhood Hits	821
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

KS6B2_MOUSE
θ value	5.07402e-19 (rank : 189)	NC score	0.851604 (rank : 189)
Query Neighborhood Hits	1762	Target Neighborhood Hits	871	Shared Neighborhood Hits	838
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

MAPK5_HUMAN
θ value	5.07402e-19 (rank : 190)	NC score	0.846456 (rank : 224)
Query Neighborhood Hits	1762	Target Neighborhood Hits	795	Shared Neighborhood Hits	777
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

PAK6_HUMAN
θ value	5.07402e-19 (rank : 191)	NC score	0.857312 (rank : 144)
Query Neighborhood Hits	1762	Target Neighborhood Hits	915	Shared Neighborhood Hits	858
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

MAPK5_MOUSE
θ value	6.62687e-19 (rank : 192)	NC score	0.847798 (rank : 211)
Query Neighborhood Hits	1762	Target Neighborhood Hits	799	Shared Neighborhood Hits	781
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

SGK3_MOUSE
θ value	6.62687e-19 (rank : 193)	NC score	0.844655 (rank : 231)
Query Neighborhood Hits	1762	Target Neighborhood Hits	882	Shared Neighborhood Hits	817
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

DSCAM_HUMAN
θ value	8.65492e-19 (rank : 194)	NC score	0.391323 (rank : 857)
Query Neighborhood Hits	1762	Target Neighborhood Hits	524	Shared Neighborhood Hits	342
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).

KKCC1_HUMAN
θ value	8.65492e-19 (rank : 195)	NC score	0.867651 (rank : 71)
Query Neighborhood Hits	1762	Target Neighborhood Hits	858	Shared Neighborhood Hits	829
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KPCA_HUMAN
θ value	8.65492e-19 (rank : 196)	NC score	0.818349 (rank : 393)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1070	Shared Neighborhood Hits	823
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

STK4_HUMAN
θ value	8.65492e-19 (rank : 197)	NC score	0.840938 (rank : 258)
Query Neighborhood Hits	1762	Target Neighborhood Hits	870	Shared Neighborhood Hits	821
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

KPCI_MOUSE
θ value	1.13037e-18 (rank : 198)	NC score	0.838914 (rank : 273)
Query Neighborhood Hits	1762	Target Neighborhood Hits	888	Shared Neighborhood Hits	824
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

M3K6_HUMAN
θ value	1.13037e-18 (rank : 199)	NC score	0.851062 (rank : 194)
Query Neighborhood Hits	1762	Target Neighborhood Hits	889	Shared Neighborhood Hits	845
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

PKN1_MOUSE
θ value	1.13037e-18 (rank : 200)	NC score	0.839587 (rank : 269)
Query Neighborhood Hits	1762	Target Neighborhood Hits	888	Shared Neighborhood Hits	824
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

CDKL5_HUMAN
θ value	1.47631e-18 (rank : 201)	NC score	0.843524 (rank : 235)
Query Neighborhood Hits	1762	Target Neighborhood Hits	967	Shared Neighborhood Hits	856
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

KS6B2_HUMAN
θ value	1.47631e-18 (rank : 202)	NC score	0.852980 (rank : 177)
Query Neighborhood Hits	1762	Target Neighborhood Hits	858	Shared Neighborhood Hits	834
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

RK_MOUSE
θ value	1.47631e-18 (rank : 203)	NC score	0.849206 (rank : 207)
Query Neighborhood Hits	1762	Target Neighborhood Hits	829	Shared Neighborhood Hits	814
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

CHK1_HUMAN
θ value	1.92812e-18 (rank : 204)	NC score	0.866334 (rank : 80)
Query Neighborhood Hits	1762	Target Neighborhood Hits	843	Shared Neighborhood Hits	818
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

IKKA_MOUSE
θ value	1.92812e-18 (rank : 205)	NC score	0.852844 (rank : 178)
Query Neighborhood Hits	1762	Target Neighborhood Hits	867	Shared Neighborhood Hits	824
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

KS6B1_HUMAN
θ value	1.92812e-18 (rank : 206)	NC score	0.853211 (rank : 176)
Query Neighborhood Hits	1762	Target Neighborhood Hits	850	Shared Neighborhood Hits	822
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B1_MOUSE
θ value	1.92812e-18 (rank : 207)	NC score	0.853230 (rank : 175)
Query Neighborhood Hits	1762	Target Neighborhood Hits	849	Shared Neighborhood Hits	822
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

M3K3_HUMAN
θ value	1.92812e-18 (rank : 208)	NC score	0.853382 (rank : 173)
Query Neighborhood Hits	1762	Target Neighborhood Hits	885	Shared Neighborhood Hits	833
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

NRCAM_MOUSE
θ value	1.92812e-18 (rank : 209)	NC score	0.381883 (rank : 882)
Query Neighborhood Hits	1762	Target Neighborhood Hits	432	Shared Neighborhood Hits	321
SwissProt Accessions	Q810U4, Q80U33, Q8BLG8, Q8BX92, Q8BYJ8	Gene names	Nrcam, Kiaa0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (mBravo).

SGK2_HUMAN
θ value	1.92812e-18 (rank : 210)	NC score	0.849936 (rank : 202)
Query Neighborhood Hits	1762	Target Neighborhood Hits	840	Shared Neighborhood Hits	819
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

GRK5_HUMAN
θ value	2.5182e-18 (rank : 211)	NC score	0.842129 (rank : 248)
Query Neighborhood Hits	1762	Target Neighborhood Hits	819	Shared Neighborhood Hits	805
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK5_MOUSE
θ value	2.5182e-18 (rank : 212)	NC score	0.842470 (rank : 246)
Query Neighborhood Hits	1762	Target Neighborhood Hits	823	Shared Neighborhood Hits	805
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

MAPK2_MOUSE
θ value	2.5182e-18 (rank : 213)	NC score	0.865705 (rank : 82)
Query Neighborhood Hits	1762	Target Neighborhood Hits	831	Shared Neighborhood Hits	807
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

PKN1_HUMAN
θ value	2.5182e-18 (rank : 214)	NC score	0.839356 (rank : 271)
Query Neighborhood Hits	1762	Target Neighborhood Hits	886	Shared Neighborhood Hits	832
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

STK24_HUMAN
θ value	2.5182e-18 (rank : 215)	NC score	0.837236 (rank : 281)
Query Neighborhood Hits	1762	Target Neighborhood Hits	853	Shared Neighborhood Hits	826
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

TSSK3_HUMAN
θ value	2.5182e-18 (rank : 216)	NC score	0.856211 (rank : 148)
Query Neighborhood Hits	1762	Target Neighborhood Hits	806	Shared Neighborhood Hits	790
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

TSSK3_MOUSE
θ value	2.5182e-18 (rank : 217)	NC score	0.855945 (rank : 153)
Query Neighborhood Hits	1762	Target Neighborhood Hits	806	Shared Neighborhood Hits	789
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

CHK1_MOUSE
θ value	3.28887e-18 (rank : 218)	NC score	0.866810 (rank : 78)
Query Neighborhood Hits	1762	Target Neighborhood Hits	839	Shared Neighborhood Hits	820
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

CDC2_HUMAN
θ value	4.29542e-18 (rank : 219)	NC score	0.835784 (rank : 291)
Query Neighborhood Hits	1762	Target Neighborhood Hits	842	Shared Neighborhood Hits	821
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

GRK4_HUMAN
θ value	4.29542e-18 (rank : 220)	NC score	0.838260 (rank : 277)
Query Neighborhood Hits	1762	Target Neighborhood Hits	822	Shared Neighborhood Hits	805
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

PAK4_HUMAN
θ value	4.29542e-18 (rank : 221)	NC score	0.856007 (rank : 151)
Query Neighborhood Hits	1762	Target Neighborhood Hits	924	Shared Neighborhood Hits	868
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

ST32C_HUMAN
θ value	4.29542e-18 (rank : 222)	NC score	0.850471 (rank : 199)
Query Neighborhood Hits	1762	Target Neighborhood Hits	832	Shared Neighborhood Hits	814
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

STK24_MOUSE
θ value	4.29542e-18 (rank : 223)	NC score	0.836407 (rank : 285)
Query Neighborhood Hits	1762	Target Neighborhood Hits	856	Shared Neighborhood Hits	827
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

MYPC3_MOUSE
θ value	5.60996e-18 (rank : 224)	NC score	0.349650 (rank : 909)
Query Neighborhood Hits	1762	Target Neighborhood Hits	310	Shared Neighborhood Hits	260
SwissProt Accessions	O70468, O88997	Gene names	Mybpc3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

PAK4_MOUSE
θ value	5.60996e-18 (rank : 225)	NC score	0.854514 (rank : 161)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1098	Shared Neighborhood Hits	923
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PTK7_HUMAN
θ value	5.60996e-18 (rank : 226)	NC score	0.769463 (rank : 536)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1103	Shared Neighborhood Hits	995
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

ST38L_MOUSE
θ value	5.60996e-18 (rank : 227)	NC score	0.824311 (rank : 367)
Query Neighborhood Hits	1762	Target Neighborhood Hits	821	Shared Neighborhood Hits	786
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

CDK2_HUMAN
θ value	7.32683e-18 (rank : 228)	NC score	0.830863 (rank : 326)
Query Neighborhood Hits	1762	Target Neighborhood Hits	832	Shared Neighborhood Hits	816
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

IKKA_HUMAN
θ value	7.32683e-18 (rank : 229)	NC score	0.850761 (rank : 198)
Query Neighborhood Hits	1762	Target Neighborhood Hits	863	Shared Neighborhood Hits	823
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

KPCB_HUMAN
θ value	7.32683e-18 (rank : 230)	NC score	0.812101 (rank : 430)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1121	Shared Neighborhood Hits	822
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_MOUSE
θ value	7.32683e-18 (rank : 231)	NC score	0.812515 (rank : 423)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1117	Shared Neighborhood Hits	821
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

M3K15_HUMAN
θ value	7.32683e-18 (rank : 232)	NC score	0.846528 (rank : 223)
Query Neighborhood Hits	1762	Target Neighborhood Hits	914	Shared Neighborhood Hits	829
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

M3K3_MOUSE
θ value	7.32683e-18 (rank : 233)	NC score	0.853684 (rank : 167)
Query Neighborhood Hits	1762	Target Neighborhood Hits	876	Shared Neighborhood Hits	833
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

SGK1_HUMAN
θ value	7.32683e-18 (rank : 234)	NC score	0.850117 (rank : 201)
Query Neighborhood Hits	1762	Target Neighborhood Hits	848	Shared Neighborhood Hits	823
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

STK3_HUMAN
θ value	7.32683e-18 (rank : 235)	NC score	0.840778 (rank : 260)
Query Neighborhood Hits	1762	Target Neighborhood Hits	861	Shared Neighborhood Hits	822
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

GRK6_HUMAN
θ value	9.56915e-18 (rank : 236)	NC score	0.842129 (rank : 249)
Query Neighborhood Hits	1762	Target Neighborhood Hits	823	Shared Neighborhood Hits	812
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

MUSK_HUMAN
θ value	9.56915e-18 (rank : 237)	NC score	0.740181 (rank : 567)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1074	Shared Neighborhood Hits	998
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

PKN2_HUMAN
θ value	9.56915e-18 (rank : 238)	NC score	0.841773 (rank : 251)
Query Neighborhood Hits	1762	Target Neighborhood Hits	892	Shared Neighborhood Hits	823
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN2_MOUSE
θ value	9.56915e-18 (rank : 239)	NC score	0.842023 (rank : 250)
Query Neighborhood Hits	1762	Target Neighborhood Hits	899	Shared Neighborhood Hits	822
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

SGK1_MOUSE
θ value	9.56915e-18 (rank : 240)	NC score	0.849920 (rank : 203)
Query Neighborhood Hits	1762	Target Neighborhood Hits	848	Shared Neighborhood Hits	822
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

STK3_MOUSE
θ value	9.56915e-18 (rank : 241)	NC score	0.841070 (rank : 256)
Query Neighborhood Hits	1762	Target Neighborhood Hits	869	Shared Neighborhood Hits	821
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

CNTN2_HUMAN
θ value	1.24977e-17 (rank : 242)	NC score	0.385354 (rank : 873)
Query Neighborhood Hits	1762	Target Neighborhood Hits	440	Shared Neighborhood Hits	326
SwissProt Accessions	Q02246, P78432	Gene names	CNTN2, TAG1, TAX1
Domain Architecture
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

GRK4_MOUSE
θ value	1.24977e-17 (rank : 243)	NC score	0.836186 (rank : 286)
Query Neighborhood Hits	1762	Target Neighborhood Hits	808	Shared Neighborhood Hits	798
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

KAPCB_HUMAN
θ value	1.24977e-17 (rank : 244)	NC score	0.854197 (rank : 162)
Query Neighborhood Hits	1762	Target Neighborhood Hits	837	Shared Neighborhood Hits	822
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KKCC2_MOUSE
θ value	1.24977e-17 (rank : 245)	NC score	0.867045 (rank : 74)
Query Neighborhood Hits	1762	Target Neighborhood Hits	855	Shared Neighborhood Hits	820
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KAPCA_HUMAN
θ value	1.63225e-17 (rank : 246)	NC score	0.854945 (rank : 159)
Query Neighborhood Hits	1762	Target Neighborhood Hits	838	Shared Neighborhood Hits	823
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

BOC_HUMAN
θ value	2.13179e-17 (rank : 247)	NC score	0.392174 (rank : 854)
Query Neighborhood Hits	1762	Target Neighborhood Hits	543	Shared Neighborhood Hits	339
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

GRK6_MOUSE
θ value	2.13179e-17 (rank : 248)	NC score	0.841354 (rank : 254)
Query Neighborhood Hits	1762	Target Neighborhood Hits	820	Shared Neighborhood Hits	811
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

ROCK1_HUMAN
θ value	2.13179e-17 (rank : 249)	NC score	0.739041 (rank : 570)
Query Neighborhood Hits	1762	Target Neighborhood Hits	2000	Shared Neighborhood Hits	881
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ROCK1_MOUSE
θ value	2.13179e-17 (rank : 250)	NC score	0.723930 (rank : 591)
Query Neighborhood Hits	1762	Target Neighborhood Hits	2126	Shared Neighborhood Hits	893
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

ST32C_MOUSE
θ value	2.13179e-17 (rank : 251)	NC score	0.852298 (rank : 185)
Query Neighborhood Hits	1762	Target Neighborhood Hits	824	Shared Neighborhood Hits	812
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

TSSK6_MOUSE
θ value	2.13179e-17 (rank : 252)	NC score	0.860504 (rank : 125)
Query Neighborhood Hits	1762	Target Neighborhood Hits	824	Shared Neighborhood Hits	810
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

IKKB_MOUSE
θ value	2.7842e-17 (rank : 253)	NC score	0.848265 (rank : 210)
Query Neighborhood Hits	1762	Target Neighborhood Hits	984	Shared Neighborhood Hits	824
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

KAPCA_MOUSE
θ value	2.7842e-17 (rank : 254)	NC score	0.855211 (rank : 157)
Query Neighborhood Hits	1762	Target Neighborhood Hits	836	Shared Neighborhood Hits	823
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KAPCB_MOUSE
θ value	2.7842e-17 (rank : 255)	NC score	0.853924 (rank : 164)
Query Neighborhood Hits	1762	Target Neighborhood Hits	836	Shared Neighborhood Hits	822
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KGP2_MOUSE
θ value	2.7842e-17 (rank : 256)	NC score	0.842970 (rank : 242)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1029	Shared Neighborhood Hits	833
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

LRIG1_HUMAN
θ value	2.7842e-17 (rank : 257)	NC score	0.280768 (rank : 963)
Query Neighborhood Hits	1762	Target Neighborhood Hits	654	Shared Neighborhood Hits	298
SwissProt Accessions	Q96JA1, Q6IQ51, Q96CF9, Q9BYB8, Q9UFI4	Gene names	LRIG1, LIG1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

MAPK2_HUMAN
θ value	2.7842e-17 (rank : 258)	NC score	0.866155 (rank : 81)
Query Neighborhood Hits	1762	Target Neighborhood Hits	844	Shared Neighborhood Hits	816
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MKNK2_MOUSE
θ value	2.7842e-17 (rank : 259)	NC score	0.860120 (rank : 129)
Query Neighborhood Hits	1762	Target Neighborhood Hits	819	Shared Neighborhood Hits	801
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

STK10_HUMAN
θ value	2.7842e-17 (rank : 260)	NC score	0.793989 (rank : 482)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1921	Shared Neighborhood Hits	929
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

ULK1_HUMAN
θ value	2.7842e-17 (rank : 261)	NC score	0.863522 (rank : 102)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1121	Shared Neighborhood Hits	920
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

ULK2_MOUSE
θ value	2.7842e-17 (rank : 262)	NC score	0.864544 (rank : 92)
Query Neighborhood Hits	1762	Target Neighborhood Hits	943	Shared Neighborhood Hits	860
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

KGP2_HUMAN
θ value	3.63628e-17 (rank : 263)	NC score	0.843304 (rank : 238)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1023	Shared Neighborhood Hits	832
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KKCC2_HUMAN
θ value	3.63628e-17 (rank : 264)	NC score	0.866951 (rank : 75)
Query Neighborhood Hits	1762	Target Neighborhood Hits	852	Shared Neighborhood Hits	823
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

M3K2_MOUSE
θ value	3.63628e-17 (rank : 265)	NC score	0.853926 (rank : 163)
Query Neighborhood Hits	1762	Target Neighborhood Hits	846	Shared Neighborhood Hits	823
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K5_HUMAN
θ value	3.63628e-17 (rank : 266)	NC score	0.847381 (rank : 216)
Query Neighborhood Hits	1762	Target Neighborhood Hits	868	Shared Neighborhood Hits	822
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K5_MOUSE
θ value	3.63628e-17 (rank : 267)	NC score	0.847477 (rank : 213)
Query Neighborhood Hits	1762	Target Neighborhood Hits	867	Shared Neighborhood Hits	824
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

ST32A_MOUSE
θ value	3.63628e-17 (rank : 268)	NC score	0.853391 (rank : 172)
Query Neighborhood Hits	1762	Target Neighborhood Hits	833	Shared Neighborhood Hits	816
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

ULK2_HUMAN
θ value	3.63628e-17 (rank : 269)	NC score	0.863856 (rank : 98)
Query Neighborhood Hits	1762	Target Neighborhood Hits	979	Shared Neighborhood Hits	872
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

CDKL2_MOUSE
θ value	4.74913e-17 (rank : 270)	NC score	0.840203 (rank : 264)
Query Neighborhood Hits	1762	Target Neighborhood Hits	854	Shared Neighborhood Hits	823
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

IKKB_HUMAN
θ value	4.74913e-17 (rank : 271)	NC score	0.848617 (rank : 209)
Query Neighborhood Hits	1762	Target Neighborhood Hits	980	Shared Neighborhood Hits	826
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

KPCA_MOUSE
θ value	4.74913e-17 (rank : 272)	NC score	0.818968 (rank : 391)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1067	Shared Neighborhood Hits	820
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCI_HUMAN
θ value	4.74913e-17 (rank : 273)	NC score	0.838451 (rank : 276)
Query Neighborhood Hits	1762	Target Neighborhood Hits	885	Shared Neighborhood Hits	824
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

MAPK3_HUMAN
θ value	4.74913e-17 (rank : 274)	NC score	0.863301 (rank : 104)
Query Neighborhood Hits	1762	Target Neighborhood Hits	807	Shared Neighborhood Hits	789
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

NEK4_MOUSE
θ value	4.74913e-17 (rank : 275)	NC score	0.852627 (rank : 184)
Query Neighborhood Hits	1762	Target Neighborhood Hits	899	Shared Neighborhood Hits	834
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

SGK2_MOUSE
θ value	4.74913e-17 (rank : 276)	NC score	0.850153 (rank : 200)
Query Neighborhood Hits	1762	Target Neighborhood Hits	833	Shared Neighborhood Hits	816
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

SGK3_HUMAN
θ value	4.74913e-17 (rank : 277)	NC score	0.844223 (rank : 232)
Query Neighborhood Hits	1762	Target Neighborhood Hits	877	Shared Neighborhood Hits	817
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

STK11_HUMAN
θ value	4.74913e-17 (rank : 278)	NC score	0.868280 (rank : 69)
Query Neighborhood Hits	1762	Target Neighborhood Hits	831	Shared Neighborhood Hits	818
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

CDC2_MOUSE
θ value	6.20254e-17 (rank : 279)	NC score	0.834807 (rank : 300)
Query Neighborhood Hits	1762	Target Neighborhood Hits	838	Shared Neighborhood Hits	820
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

MKNK2_HUMAN
θ value	6.20254e-17 (rank : 280)	NC score	0.860634 (rank : 122)
Query Neighborhood Hits	1762	Target Neighborhood Hits	821	Shared Neighborhood Hits	803
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

M3K13_HUMAN
θ value	8.10077e-17 (rank : 281)	NC score	0.802257 (rank : 458)
Query Neighborhood Hits	1762	Target Neighborhood Hits	911	Shared Neighborhood Hits	828
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

MAPK3_MOUSE
θ value	8.10077e-17 (rank : 282)	NC score	0.863816 (rank : 100)
Query Neighborhood Hits	1762	Target Neighborhood Hits	811	Shared Neighborhood Hits	797
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

MARK3_HUMAN
θ value	8.10077e-17 (rank : 283)	NC score	0.855978 (rank : 152)
Query Neighborhood Hits	1762	Target Neighborhood Hits	893	Shared Neighborhood Hits	829
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

RK_HUMAN
θ value	8.10077e-17 (rank : 284)	NC score	0.846354 (rank : 225)
Query Neighborhood Hits	1762	Target Neighborhood Hits	835	Shared Neighborhood Hits	816
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

STK10_MOUSE
θ value	8.10077e-17 (rank : 285)	NC score	0.772694 (rank : 528)
Query Neighborhood Hits	1762	Target Neighborhood Hits	2132	Shared Neighborhood Hits	954
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

M3K12_HUMAN
θ value	1.058e-16 (rank : 286)	NC score	0.794955 (rank : 478)
Query Neighborhood Hits	1762	Target Neighborhood Hits	940	Shared Neighborhood Hits	851
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	1.058e-16 (rank : 287)	NC score	0.794796 (rank : 479)
Query Neighborhood Hits	1762	Target Neighborhood Hits	957	Shared Neighborhood Hits	854
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

NEK4_HUMAN
θ value	1.058e-16 (rank : 288)	NC score	0.851377 (rank : 192)
Query Neighborhood Hits	1762	Target Neighborhood Hits	883	Shared Neighborhood Hits	829
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

PFTK1_HUMAN
θ value	1.058e-16 (rank : 289)	NC score	0.829524 (rank : 337)
Query Neighborhood Hits	1762	Target Neighborhood Hits	834	Shared Neighborhood Hits	812
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

ST32A_HUMAN
θ value	1.058e-16 (rank : 290)	NC score	0.852837 (rank : 180)
Query Neighborhood Hits	1762	Target Neighborhood Hits	834	Shared Neighborhood Hits	819
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

CD2L7_HUMAN
θ value	1.38178e-16 (rank : 291)	NC score	0.824536 (rank : 365)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1275	Shared Neighborhood Hits	967
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

CDK3_HUMAN
θ value	1.38178e-16 (rank : 292)	NC score	0.832182 (rank : 318)
Query Neighborhood Hits	1762	Target Neighborhood Hits	843	Shared Neighborhood Hits	823
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

CNTN2_MOUSE
θ value	1.38178e-16 (rank : 293)	NC score	0.384917 (rank : 874)
Query Neighborhood Hits	1762	Target Neighborhood Hits	450	Shared Neighborhood Hits	331
SwissProt Accessions	Q61330, Q6NZJ4, Q7TSJ5	Gene names	Cntn2, Tax
Domain Architecture	No domain graphic available
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CTRO_HUMAN
θ value	1.38178e-16 (rank : 294)	NC score	0.738376 (rank : 571)
Query Neighborhood Hits	1762	Target Neighborhood Hits	2092	Shared Neighborhood Hits	905
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

MYPC2_MOUSE
θ value	1.38178e-16 (rank : 295)	NC score	0.351070 (rank : 907)
Query Neighborhood Hits	1762	Target Neighborhood Hits	297	Shared Neighborhood Hits	252
SwissProt Accessions	Q5XKE0, Q8C109, Q8K2V0	Gene names	Mybpc2
Domain Architecture	No domain graphic available
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

STK38_MOUSE
θ value	1.38178e-16 (rank : 296)	NC score	0.828977 (rank : 341)
Query Neighborhood Hits	1762	Target Neighborhood Hits	838	Shared Neighborhood Hits	795
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

TSSK6_HUMAN
θ value	1.38178e-16 (rank : 297)	NC score	0.859333 (rank : 134)
Query Neighborhood Hits	1762	Target Neighborhood Hits	824	Shared Neighborhood Hits	811
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

ULK1_MOUSE
θ value	1.38178e-16 (rank : 298)	NC score	0.861390 (rank : 117)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1214	Shared Neighborhood Hits	944
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

DMPK_MOUSE
θ value	1.80466e-16 (rank : 299)	NC score	0.824920 (rank : 361)
Query Neighborhood Hits	1762	Target Neighborhood Hits	908	Shared Neighborhood Hits	814
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

IKKE_HUMAN
θ value	1.80466e-16 (rank : 300)	NC score	0.848850 (rank : 208)
Query Neighborhood Hits	1762	Target Neighborhood Hits	837	Shared Neighborhood Hits	800
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

KPCZ_HUMAN
θ value	1.80466e-16 (rank : 301)	NC score	0.834197 (rank : 303)
Query Neighborhood Hits	1762	Target Neighborhood Hits	884	Shared Neighborhood Hits	820
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

MRCKB_MOUSE
θ value	1.80466e-16 (rank : 302)	NC score	0.729088 (rank : 587)
Query Neighborhood Hits	1762	Target Neighborhood Hits	2180	Shared Neighborhood Hits	914
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MST4_HUMAN
θ value	1.80466e-16 (rank : 303)	NC score	0.836025 (rank : 288)
Query Neighborhood Hits	1762	Target Neighborhood Hits	852	Shared Neighborhood Hits	822
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MST4_MOUSE
θ value	1.80466e-16 (rank : 304)	NC score	0.836076 (rank : 287)
Query Neighborhood Hits	1762	Target Neighborhood Hits	860	Shared Neighborhood Hits	822
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

NEK1_HUMAN
θ value	1.80466e-16 (rank : 305)	NC score	0.851493 (rank : 190)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1129	Shared Neighborhood Hits	845
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

NEK1_MOUSE
θ value	1.80466e-16 (rank : 306)	NC score	0.850801 (rank : 197)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1311	Shared Neighborhood Hits	875
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

NEK8_HUMAN
θ value	1.80466e-16 (rank : 307)	NC score	0.843509 (rank : 236)
Query Neighborhood Hits	1762	Target Neighborhood Hits	872	Shared Neighborhood Hits	825
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

NEK8_MOUSE
θ value	1.80466e-16 (rank : 308)	NC score	0.843568 (rank : 234)
Query Neighborhood Hits	1762	Target Neighborhood Hits	872	Shared Neighborhood Hits	825
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

NRCAM_HUMAN
θ value	1.80466e-16 (rank : 309)	NC score	0.378637 (rank : 887)
Query Neighborhood Hits	1762	Target Neighborhood Hits	439	Shared Neighborhood Hits	326
SwissProt Accessions	Q92823, O15051, O15179, Q9UHI3, Q9UHI4	Gene names	NRCAM, KIAA0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (hBravo).

ROCK2_HUMAN
θ value	1.80466e-16 (rank : 310)	NC score	0.742605 (rank : 561)
Query Neighborhood Hits	1762	Target Neighborhood Hits	2073	Shared Neighborhood Hits	884
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

CDK2_MOUSE
θ value	2.35696e-16 (rank : 311)	NC score	0.828320 (rank : 345)
Query Neighborhood Hits	1762	Target Neighborhood Hits	828	Shared Neighborhood Hits	814
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

CDKL3_MOUSE
θ value	2.35696e-16 (rank : 312)	NC score	0.846657 (rank : 222)
Query Neighborhood Hits	1762	Target Neighborhood Hits	857	Shared Neighborhood Hits	826
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

KPCL_MOUSE
θ value	2.35696e-16 (rank : 313)	NC score	0.835594 (rank : 294)
Query Neighborhood Hits	1762	Target Neighborhood Hits	891	Shared Neighborhood Hits	811
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

M3K2_HUMAN
θ value	2.35696e-16 (rank : 314)	NC score	0.852293 (rank : 186)
Query Neighborhood Hits	1762	Target Neighborhood Hits	849	Shared Neighborhood Hits	824
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

MRCKG_HUMAN
θ value	2.35696e-16 (rank : 315)	NC score	0.791459 (rank : 488)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1519	Shared Neighborhood Hits	858
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

MUSK_MOUSE
θ value	2.35696e-16 (rank : 316)	NC score	0.736893 (rank : 574)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1057	Shared Neighborhood Hits	989
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

NCAM2_MOUSE
θ value	2.35696e-16 (rank : 317)	NC score	0.390942 (rank : 858)
Query Neighborhood Hits	1762	Target Neighborhood Hits	472	Shared Neighborhood Hits	324
SwissProt Accessions	O35136, O35962	Gene names	Ncam2, Ocam, Rncam
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2) (RB-8 neural cell adhesion molecule) (R4B12).

SDK2_HUMAN
θ value	2.35696e-16 (rank : 318)	NC score	0.374787 (rank : 889)
Query Neighborhood Hits	1762	Target Neighborhood Hits	495	Shared Neighborhood Hits	338
SwissProt Accessions	Q58EX2, Q86VY3, Q9NTD2, Q9NVB3, Q9P214	Gene names	SDK2, KIAA1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

CDK7_HUMAN
θ value	3.07829e-16 (rank : 319)	NC score	0.829319 (rank : 339)
Query Neighborhood Hits	1762	Target Neighborhood Hits	833	Shared Neighborhood Hits	812
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

CDK7_MOUSE
θ value	3.07829e-16 (rank : 320)	NC score	0.829469 (rank : 338)
Query Neighborhood Hits	1762	Target Neighborhood Hits	835	Shared Neighborhood Hits	813
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

IKKE_MOUSE
θ value	3.07829e-16 (rank : 321)	NC score	0.847445 (rank : 214)
Query Neighborhood Hits	1762	Target Neighborhood Hits	848	Shared Neighborhood Hits	801
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

NIM1_HUMAN
θ value	3.07829e-16 (rank : 322)	NC score	0.862535 (rank : 110)
Query Neighborhood Hits	1762	Target Neighborhood Hits	850	Shared Neighborhood Hits	823
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

NIM1_MOUSE
θ value	3.07829e-16 (rank : 323)	NC score	0.863776 (rank : 101)
Query Neighborhood Hits	1762	Target Neighborhood Hits	850	Shared Neighborhood Hits	825
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

ROCK2_MOUSE
θ value	3.07829e-16 (rank : 324)	NC score	0.735723 (rank : 575)
Query Neighborhood Hits	1762	Target Neighborhood Hits	2072	Shared Neighborhood Hits	884
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

CDKL3_HUMAN
θ value	4.02038e-16 (rank : 325)	NC score	0.845817 (rank : 229)
Query Neighborhood Hits	1762	Target Neighborhood Hits	853	Shared Neighborhood Hits	826
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

KPCL_HUMAN
θ value	4.02038e-16 (rank : 326)	NC score	0.833321 (rank : 311)
Query Neighborhood Hits	1762	Target Neighborhood Hits	887	Shared Neighborhood Hits	811
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KPCZ_MOUSE
θ value	4.02038e-16 (rank : 327)	NC score	0.834219 (rank : 302)
Query Neighborhood Hits	1762	Target Neighborhood Hits	882	Shared Neighborhood Hits	819
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

LRIG1_MOUSE
θ value	4.02038e-16 (rank : 328)	NC score	0.274969 (rank : 972)
Query Neighborhood Hits	1762	Target Neighborhood Hits	627	Shared Neighborhood Hits	288
SwissProt Accessions	P70193	Gene names	Lrig1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

MAK_MOUSE
θ value	4.02038e-16 (rank : 329)	NC score	0.830088 (rank : 331)
Query Neighborhood Hits	1762	Target Neighborhood Hits	873	Shared Neighborhood Hits	825
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

PFTK1_MOUSE
θ value	4.02038e-16 (rank : 330)	NC score	0.829591 (rank : 336)
Query Neighborhood Hits	1762	Target Neighborhood Hits	835	Shared Neighborhood Hits	811
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

SDK2_MOUSE
θ value	4.02038e-16 (rank : 331)	NC score	0.373991 (rank : 890)
Query Neighborhood Hits	1762	Target Neighborhood Hits	480	Shared Neighborhood Hits	340
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

STK38_HUMAN
θ value	4.02038e-16 (rank : 332)	NC score	0.829030 (rank : 340)
Query Neighborhood Hits	1762	Target Neighborhood Hits	840	Shared Neighborhood Hits	795
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

KPCT_HUMAN
θ value	6.85773e-16 (rank : 333)	NC score	0.839341 (rank : 272)
Query Neighborhood Hits	1762	Target Neighborhood Hits	897	Shared Neighborhood Hits	824
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

LRIG2_MOUSE
θ value	6.85773e-16 (rank : 334)	NC score	0.277318 (rank : 970)
Query Neighborhood Hits	1762	Target Neighborhood Hits	586	Shared Neighborhood Hits	286
SwissProt Accessions	Q52KR2, Q69ZY8	Gene names	Lrig2, Kiaa0806
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor.

M4K1_HUMAN
θ value	6.85773e-16 (rank : 335)	NC score	0.832553 (rank : 317)
Query Neighborhood Hits	1762	Target Neighborhood Hits	884	Shared Neighborhood Hits	831
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

MRCKB_HUMAN
θ value	6.85773e-16 (rank : 336)	NC score	0.721174 (rank : 594)
Query Neighborhood Hits	1762	Target Neighborhood Hits	2239	Shared Neighborhood Hits	929
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MRCKG_MOUSE
θ value	6.85773e-16 (rank : 337)	NC score	0.790395 (rank : 493)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1466	Shared Neighborhood Hits	849
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

KPCE_HUMAN
θ value	8.95645e-16 (rank : 338)	NC score	0.833221 (rank : 313)
Query Neighborhood Hits	1762	Target Neighborhood Hits	906	Shared Neighborhood Hits	818
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCT_MOUSE
θ value	8.95645e-16 (rank : 339)	NC score	0.839737 (rank : 268)
Query Neighborhood Hits	1762	Target Neighborhood Hits	895	Shared Neighborhood Hits	822
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

MAK_HUMAN
θ value	8.95645e-16 (rank : 340)	NC score	0.828824 (rank : 342)
Query Neighborhood Hits	1762	Target Neighborhood Hits	857	Shared Neighborhood Hits	819
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

PKN3_HUMAN
θ value	8.95645e-16 (rank : 341)	NC score	0.840833 (rank : 259)
Query Neighborhood Hits	1762	Target Neighborhood Hits	893	Shared Neighborhood Hits	832
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PTPRD_HUMAN
θ value	8.95645e-16 (rank : 342)	NC score	0.275871 (rank : 971)
Query Neighborhood Hits	1762	Target Neighborhood Hits	485	Shared Neighborhood Hits	310
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

SDK1_HUMAN
θ value	8.95645e-16 (rank : 343)	NC score	0.378722 (rank : 886)
Query Neighborhood Hits	1762	Target Neighborhood Hits	511	Shared Neighborhood Hits	352
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

CD2L5_HUMAN
θ value	1.16975e-15 (rank : 344)	NC score	0.819343 (rank : 386)
Query Neighborhood Hits	1762	Target Neighborhood Hits	987	Shared Neighborhood Hits	857
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CD2L5_MOUSE
θ value	1.16975e-15 (rank : 345)	NC score	0.819626 (rank : 384)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1011	Shared Neighborhood Hits	871
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CDK9_HUMAN
θ value	1.16975e-15 (rank : 346)	NC score	0.813027 (rank : 421)
Query Neighborhood Hits	1762	Target Neighborhood Hits	822	Shared Neighborhood Hits	806
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

CDKL2_HUMAN
θ value	1.16975e-15 (rank : 347)	NC score	0.839474 (rank : 270)
Query Neighborhood Hits	1762	Target Neighborhood Hits	838	Shared Neighborhood Hits	818
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

TAOK2_MOUSE
θ value	1.16975e-15 (rank : 348)	NC score	0.802799 (rank : 457)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1373	Shared Neighborhood Hits	866
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

KPCD_MOUSE
θ value	1.52774e-15 (rank : 349)	NC score	0.832820 (rank : 316)
Query Neighborhood Hits	1762	Target Neighborhood Hits	888	Shared Neighborhood Hits	816
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

MINK1_HUMAN
θ value	1.52774e-15 (rank : 350)	NC score	0.812221 (rank : 428)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1477	Shared Neighborhood Hits	919
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_MOUSE
θ value	1.52774e-15 (rank : 351)	NC score	0.812022 (rank : 432)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1451	Shared Neighborhood Hits	901
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MK07_MOUSE
θ value	1.52774e-15 (rank : 352)	NC score	0.819991 (rank : 382)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1054	Shared Neighborhood Hits	926
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

MRCKA_HUMAN
θ value	1.52774e-15 (rank : 353)	NC score	0.741179 (rank : 564)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1999	Shared Neighborhood Hits	883
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

PCTK2_HUMAN
θ value	1.52774e-15 (rank : 354)	NC score	0.823241 (rank : 371)
Query Neighborhood Hits	1762	Target Neighborhood Hits	837	Shared Neighborhood Hits	812
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK2_MOUSE
θ value	1.52774e-15 (rank : 355)	NC score	0.822880 (rank : 374)
Query Neighborhood Hits	1762	Target Neighborhood Hits	836	Shared Neighborhood Hits	813
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK3_HUMAN
θ value	1.52774e-15 (rank : 356)	NC score	0.824602 (rank : 364)
Query Neighborhood Hits	1762	Target Neighborhood Hits	827	Shared Neighborhood Hits	806
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

SDK1_MOUSE
θ value	1.52774e-15 (rank : 357)	NC score	0.376595 (rank : 888)
Query Neighborhood Hits	1762	Target Neighborhood Hits	495	Shared Neighborhood Hits	339
SwissProt Accessions	Q3UH53, Q3UFD1, Q6PAL2, Q6V3A4, Q8BMC2, Q8BZI1	Gene names	Sdk1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

PTPRD_MOUSE
θ value	1.99529e-15 (rank : 358)	NC score	0.281172 (rank : 961)
Query Neighborhood Hits	1762	Target Neighborhood Hits	491	Shared Neighborhood Hits	318
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

TBK1_HUMAN
θ value	1.99529e-15 (rank : 359)	NC score	0.846340 (rank : 226)
Query Neighborhood Hits	1762	Target Neighborhood Hits	861	Shared Neighborhood Hits	792
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

CDK9_MOUSE
θ value	2.60593e-15 (rank : 360)	NC score	0.812421 (rank : 425)
Query Neighborhood Hits	1762	Target Neighborhood Hits	822	Shared Neighborhood Hits	806
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

MK01_HUMAN
θ value	2.60593e-15 (rank : 361)	NC score	0.812179 (rank : 429)
Query Neighborhood Hits	1762	Target Neighborhood Hits	836	Shared Neighborhood Hits	816
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

PASK_MOUSE
θ value	2.60593e-15 (rank : 362)	NC score	0.863156 (rank : 106)
Query Neighborhood Hits	1762	Target Neighborhood Hits	867	Shared Neighborhood Hits	823
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

TAOK1_HUMAN
θ value	2.60593e-15 (rank : 363)	NC score	0.780632 (rank : 518)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1734	Shared Neighborhood Hits	892
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

TAOK1_MOUSE
θ value	2.60593e-15 (rank : 364)	NC score	0.780999 (rank : 515)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1720	Shared Neighborhood Hits	889
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

TBK1_MOUSE
θ value	2.60593e-15 (rank : 365)	NC score	0.845993 (rank : 228)
Query Neighborhood Hits	1762	Target Neighborhood Hits	893	Shared Neighborhood Hits	794
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

ULK3_HUMAN
θ value	2.60593e-15 (rank : 366)	NC score	0.870769 (rank : 52)
Query Neighborhood Hits	1762	Target Neighborhood Hits	830	Shared Neighborhood Hits	818
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

M4K4_HUMAN
θ value	3.40345e-15 (rank : 367)	NC score	0.799130 (rank : 469)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1589	Shared Neighborhood Hits	882
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MK01_MOUSE
θ value	3.40345e-15 (rank : 368)	NC score	0.811971 (rank : 434)
Query Neighborhood Hits	1762	Target Neighborhood Hits	836	Shared Neighborhood Hits	816
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK07_HUMAN
θ value	3.40345e-15 (rank : 369)	NC score	0.819701 (rank : 383)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1087	Shared Neighborhood Hits	946
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

NLK_HUMAN
θ value	3.40345e-15 (rank : 370)	NC score	0.816852 (rank : 401)
Query Neighborhood Hits	1762	Target Neighborhood Hits	840	Shared Neighborhood Hits	821
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

NLK_MOUSE
θ value	3.40345e-15 (rank : 371)	NC score	0.816922 (rank : 399)
Query Neighborhood Hits	1762	Target Neighborhood Hits	839	Shared Neighborhood Hits	821
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

SLK_MOUSE
θ value	3.40345e-15 (rank : 372)	NC score	0.812383 (rank : 426)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1798	Shared Neighborhood Hits	896
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

TAOK2_HUMAN
θ value	3.40345e-15 (rank : 373)	NC score	0.815496 (rank : 406)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1172	Shared Neighborhood Hits	857
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

TTK_HUMAN
θ value	3.40345e-15 (rank : 374)	NC score	0.843308 (rank : 237)
Query Neighborhood Hits	1762	Target Neighborhood Hits	816	Shared Neighborhood Hits	776
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

TTK_MOUSE
θ value	3.40345e-15 (rank : 375)	NC score	0.841577 (rank : 252)
Query Neighborhood Hits	1762	Target Neighborhood Hits	803	Shared Neighborhood Hits	757
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

LRIG2_HUMAN
θ value	4.44505e-15 (rank : 376)	NC score	0.278347 (rank : 967)
Query Neighborhood Hits	1762	Target Neighborhood Hits	595	Shared Neighborhood Hits	288
SwissProt Accessions	O94898, Q9NSN2	Gene names	LRIG2, KIAA0806, LIG2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor (LIG-2).

MAST2_HUMAN
θ value	4.44505e-15 (rank : 377)	NC score	0.835833 (rank : 290)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1189	Shared Neighborhood Hits	914
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MK03_MOUSE
θ value	4.44505e-15 (rank : 378)	NC score	0.814283 (rank : 412)
Query Neighborhood Hits	1762	Target Neighborhood Hits	840	Shared Neighborhood Hits	817
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

MP2K2_MOUSE
θ value	4.44505e-15 (rank : 379)	NC score	0.834084 (rank : 304)
Query Neighborhood Hits	1762	Target Neighborhood Hits	828	Shared Neighborhood Hits	814
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

TSSK4_MOUSE
θ value	4.44505e-15 (rank : 380)	NC score	0.860548 (rank : 124)
Query Neighborhood Hits	1762	Target Neighborhood Hits	840	Shared Neighborhood Hits	824
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

AL2S7_HUMAN
θ value	5.8054e-15 (rank : 381)	NC score	0.820467 (rank : 380)
Query Neighborhood Hits	1762	Target Neighborhood Hits	831	Shared Neighborhood Hits	811
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

KPCE_MOUSE
θ value	5.8054e-15 (rank : 382)	NC score	0.833279 (rank : 312)
Query Neighborhood Hits	1762	Target Neighborhood Hits	906	Shared Neighborhood Hits	820
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

MAST2_MOUSE
θ value	5.8054e-15 (rank : 383)	NC score	0.837021 (rank : 282)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1110	Shared Neighborhood Hits	890
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

DMPK_HUMAN
θ value	7.58209e-15 (rank : 384)	NC score	0.824494 (rank : 366)
Query Neighborhood Hits	1762	Target Neighborhood Hits	944	Shared Neighborhood Hits	819
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

FGRL1_HUMAN
θ value	7.58209e-15 (rank : 385)	NC score	0.389518 (rank : 863)
Query Neighborhood Hits	1762	Target Neighborhood Hits	335	Shared Neighborhood Hits	267
SwissProt Accessions	Q8N441, Q6PJN1, Q9BXN7, Q9H4D7	Gene names	FGFRL1, FGFR5, FHFR
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5) (FGFR-like protein) (FGF homologous factor receptor).

MYOTI_MOUSE
θ value	7.58209e-15 (rank : 386)	NC score	0.396167 (rank : 850)
Query Neighborhood Hits	1762	Target Neighborhood Hits	297	Shared Neighborhood Hits	257
SwissProt Accessions	Q9JIF9	Gene names	Myot, Ttid
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein).

PCTK3_MOUSE
θ value	7.58209e-15 (rank : 387)	NC score	0.826529 (rank : 351)
Query Neighborhood Hits	1762	Target Neighborhood Hits	834	Shared Neighborhood Hits	811
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

TNIK_HUMAN
θ value	7.58209e-15 (rank : 388)	NC score	0.810994 (rank : 436)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1570	Shared Neighborhood Hits	909
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

TSSK1_MOUSE
θ value	7.58209e-15 (rank : 389)	NC score	0.858200 (rank : 140)
Query Neighborhood Hits	1762	Target Neighborhood Hits	835	Shared Neighborhood Hits	810
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

FGRL1_MOUSE
θ value	9.90251e-15 (rank : 390)	NC score	0.388615 (rank : 865)
Query Neighborhood Hits	1762	Target Neighborhood Hits	325	Shared Neighborhood Hits	271
SwissProt Accessions	Q91V87, Q920C2, Q920C3	Gene names	Fgfrl1, Fgfr5
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5).

LRIG3_HUMAN
θ value	9.90251e-15 (rank : 391)	NC score	0.263604 (rank : 983)
Query Neighborhood Hits	1762	Target Neighborhood Hits	601	Shared Neighborhood Hits	290
SwissProt Accessions	Q6UXM1, Q6UXL7, Q8NC72	Gene names	LRIG3, LIG3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor (LIG-3).

MK12_MOUSE
θ value	9.90251e-15 (rank : 392)	NC score	0.822868 (rank : 375)
Query Neighborhood Hits	1762	Target Neighborhood Hits	835	Shared Neighborhood Hits	814
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MYPC3_HUMAN
θ value	9.90251e-15 (rank : 393)	NC score	0.347135 (rank : 914)
Query Neighborhood Hits	1762	Target Neighborhood Hits	318	Shared Neighborhood Hits	265
SwissProt Accessions	Q14896, Q16410, Q6R2F7, Q9UE27, Q9UM53	Gene names	MYBPC3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

NCA11_HUMAN
θ value	9.90251e-15 (rank : 394)	NC score	0.384761 (rank : 876)
Query Neighborhood Hits	1762	Target Neighborhood Hits	443	Shared Neighborhood Hits	317
SwissProt Accessions	P13591, Q15829, Q16180	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM 140) (NCAM-140) (CD56 antigen).

NEK11_MOUSE
θ value	9.90251e-15 (rank : 395)	NC score	0.847557 (rank : 212)
Query Neighborhood Hits	1762	Target Neighborhood Hits	875	Shared Neighborhood Hits	823
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

PTPRF_HUMAN
θ value	9.90251e-15 (rank : 396)	NC score	0.280911 (rank : 962)
Query Neighborhood Hits	1762	Target Neighborhood Hits	489	Shared Neighborhood Hits	319
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

ARBK1_MOUSE
θ value	1.29331e-14 (rank : 397)	NC score	0.830742 (rank : 328)
Query Neighborhood Hits	1762	Target Neighborhood Hits	849	Shared Neighborhood Hits	811
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

ICK_HUMAN
θ value	1.29331e-14 (rank : 398)	NC score	0.830324 (rank : 330)
Query Neighborhood Hits	1762	Target Neighborhood Hits	867	Shared Neighborhood Hits	828
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

LRIG3_MOUSE
θ value	1.29331e-14 (rank : 399)	NC score	0.266415 (rank : 980)
Query Neighborhood Hits	1762	Target Neighborhood Hits	611	Shared Neighborhood Hits	289
SwissProt Accessions	Q6P1C6, Q6ZPE6, Q8BRF0, Q8BS51, Q8C5E4	Gene names	Lrig3, Kiaa3016
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor.

LSAMP_HUMAN
θ value	1.29331e-14 (rank : 400)	NC score	0.366171 (rank : 893)
Query Neighborhood Hits	1762	Target Neighborhood Hits	347	Shared Neighborhood Hits	273
SwissProt Accessions	Q13449, Q8IV49	Gene names	LSAMP, LAMP
Domain Architecture
Description	Limbic system-associated membrane protein precursor (LSAMP).

M4K5_HUMAN
θ value	1.29331e-14 (rank : 401)	NC score	0.825711 (rank : 355)
Query Neighborhood Hits	1762	Target Neighborhood Hits	845	Shared Neighborhood Hits	814
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

MAST3_HUMAN
θ value	1.29331e-14 (rank : 402)	NC score	0.840313 (rank : 263)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1128	Shared Neighborhood Hits	923
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

PCTK1_HUMAN
θ value	1.29331e-14 (rank : 403)	NC score	0.825625 (rank : 356)
Query Neighborhood Hits	1762	Target Neighborhood Hits	832	Shared Neighborhood Hits	812
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

PCTK1_MOUSE
θ value	1.29331e-14 (rank : 404)	NC score	0.825423 (rank : 357)
Query Neighborhood Hits	1762	Target Neighborhood Hits	832	Shared Neighborhood Hits	811
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

TSSK2_HUMAN
θ value	1.29331e-14 (rank : 405)	NC score	0.857422 (rank : 143)
Query Neighborhood Hits	1762	Target Neighborhood Hits	826	Shared Neighborhood Hits	810
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

ULK4_MOUSE
θ value	1.29331e-14 (rank : 406)	NC score	0.853841 (rank : 166)
Query Neighborhood Hits	1762	Target Neighborhood Hits	793	Shared Neighborhood Hits	770
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

ARBK1_HUMAN
θ value	1.68911e-14 (rank : 407)	NC score	0.831597 (rank : 319)
Query Neighborhood Hits	1762	Target Neighborhood Hits	859	Shared Neighborhood Hits	812
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

CDK3_MOUSE
θ value	1.68911e-14 (rank : 408)	NC score	0.834981 (rank : 298)
Query Neighborhood Hits	1762	Target Neighborhood Hits	829	Shared Neighborhood Hits	813
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

CDK5_HUMAN
θ value	1.68911e-14 (rank : 409)	NC score	0.825920 (rank : 352)
Query Neighborhood Hits	1762	Target Neighborhood Hits	826	Shared Neighborhood Hits	812
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

CDK5_MOUSE
θ value	1.68911e-14 (rank : 410)	NC score	0.825783 (rank : 354)
Query Neighborhood Hits	1762	Target Neighborhood Hits	826	Shared Neighborhood Hits	812
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

ICK_MOUSE
θ value	1.68911e-14 (rank : 411)	NC score	0.831028 (rank : 323)
Query Neighborhood Hits	1762	Target Neighborhood Hits	860	Shared Neighborhood Hits	827
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

M4K5_MOUSE
θ value	1.68911e-14 (rank : 412)	NC score	0.826947 (rank : 350)
Query Neighborhood Hits	1762	Target Neighborhood Hits	839	Shared Neighborhood Hits	810
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

MAST4_HUMAN
θ value	1.68911e-14 (rank : 413)	NC score	0.831260 (rank : 322)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1804	Shared Neighborhood Hits	1083
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MK03_HUMAN
θ value	1.68911e-14 (rank : 414)	NC score	0.814157 (rank : 414)
Query Neighborhood Hits	1762	Target Neighborhood Hits	837	Shared Neighborhood Hits	817
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

MP2K2_HUMAN
θ value	1.68911e-14 (rank : 415)	NC score	0.835389 (rank : 296)
Query Neighborhood Hits	1762	Target Neighborhood Hits	830	Shared Neighborhood Hits	815
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

NCAM2_HUMAN
θ value	1.68911e-14 (rank : 416)	NC score	0.389379 (rank : 864)
Query Neighborhood Hits	1762	Target Neighborhood Hits	441	Shared Neighborhood Hits	319
SwissProt Accessions	O15394	Gene names	NCAM2, NCAM21
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2).

PASK_HUMAN
θ value	1.68911e-14 (rank : 417)	NC score	0.859184 (rank : 135)
Query Neighborhood Hits	1762	Target Neighborhood Hits	857	Shared Neighborhood Hits	816
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

STK25_HUMAN
θ value	1.68911e-14 (rank : 418)	NC score	0.834241 (rank : 301)
Query Neighborhood Hits	1762	Target Neighborhood Hits	853	Shared Neighborhood Hits	822
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

YSK4_HUMAN
θ value	1.68911e-14 (rank : 419)	NC score	0.841509 (rank : 253)
Query Neighborhood Hits	1762	Target Neighborhood Hits	921	Shared Neighborhood Hits	827
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

KPCD_HUMAN
θ value	2.20605e-14 (rank : 420)	NC score	0.833896 (rank : 305)
Query Neighborhood Hits	1762	Target Neighborhood Hits	900	Shared Neighborhood Hits	818
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

LSAMP_MOUSE
θ value	2.20605e-14 (rank : 421)	NC score	0.365988 (rank : 895)
Query Neighborhood Hits	1762	Target Neighborhood Hits	344	Shared Neighborhood Hits	272
SwissProt Accessions	Q8BLK3	Gene names	Lsamp
Domain Architecture	No domain graphic available
Description	Limbic system-associated membrane protein precursor (LSAMP).

M4K1_MOUSE
θ value	2.20605e-14 (rank : 422)	NC score	0.830857 (rank : 327)
Query Neighborhood Hits	1762	Target Neighborhood Hits	858	Shared Neighborhood Hits	827
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

MAST1_MOUSE
θ value	2.20605e-14 (rank : 423)	NC score	0.833018 (rank : 315)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1123	Shared Neighborhood Hits	886
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

NEK2_HUMAN
θ value	2.20605e-14 (rank : 424)	NC score	0.852839 (rank : 179)
Query Neighborhood Hits	1762	Target Neighborhood Hits	908	Shared Neighborhood Hits	811
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

NEK2_MOUSE
θ value	2.20605e-14 (rank : 425)	NC score	0.852696 (rank : 182)
Query Neighborhood Hits	1762	Target Neighborhood Hits	876	Shared Neighborhood Hits	806
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

SLK_HUMAN
θ value	2.20605e-14 (rank : 426)	NC score	0.810546 (rank : 438)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1775	Shared Neighborhood Hits	891
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

STK25_MOUSE
θ value	2.20605e-14 (rank : 427)	NC score	0.833862 (rank : 306)
Query Neighborhood Hits	1762	Target Neighborhood Hits	851	Shared Neighborhood Hits	822
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

TAOK3_MOUSE
θ value	2.20605e-14 (rank : 428)	NC score	0.793110 (rank : 485)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1458	Shared Neighborhood Hits	857
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

CTRO_MOUSE
θ value	3.76295e-14 (rank : 429)	NC score	0.717228 (rank : 600)
Query Neighborhood Hits	1762	Target Neighborhood Hits	2344	Shared Neighborhood Hits	928
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

MKNK1_HUMAN
θ value	3.76295e-14 (rank : 430)	NC score	0.815103 (rank : 409)
Query Neighborhood Hits	1762	Target Neighborhood Hits	701	Shared Neighborhood Hits	686
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

NEK11_HUMAN
θ value	3.76295e-14 (rank : 431)	NC score	0.844174 (rank : 233)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1043	Shared Neighborhood Hits	841
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

TSSK4_HUMAN
θ value	3.76295e-14 (rank : 432)	NC score	0.858679 (rank : 138)
Query Neighborhood Hits	1762	Target Neighborhood Hits	836	Shared Neighborhood Hits	824
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

MAST1_HUMAN
θ value	4.91457e-14 (rank : 433)	NC score	0.833543 (rank : 310)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1146	Shared Neighborhood Hits	902
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

ST32B_HUMAN
θ value	4.91457e-14 (rank : 434)	NC score	0.850817 (rank : 196)
Query Neighborhood Hits	1762	Target Neighborhood Hits	830	Shared Neighborhood Hits	817
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

TSSK1_HUMAN
θ value	4.91457e-14 (rank : 435)	NC score	0.854962 (rank : 158)
Query Neighborhood Hits	1762	Target Neighborhood Hits	840	Shared Neighborhood Hits	808
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

M3K4_MOUSE
θ value	6.41864e-14 (rank : 436)	NC score	0.846257 (rank : 227)
Query Neighborhood Hits	1762	Target Neighborhood Hits	924	Shared Neighborhood Hits	836
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

NEK7_HUMAN
θ value	6.41864e-14 (rank : 437)	NC score	0.846755 (rank : 220)
Query Neighborhood Hits	1762	Target Neighborhood Hits	846	Shared Neighborhood Hits	826
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

TAOK3_HUMAN
θ value	6.41864e-14 (rank : 438)	NC score	0.790464 (rank : 492)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1494	Shared Neighborhood Hits	862
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

ARBK2_HUMAN
θ value	8.38298e-14 (rank : 439)	NC score	0.831022 (rank : 324)
Query Neighborhood Hits	1762	Target Neighborhood Hits	849	Shared Neighborhood Hits	812
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

E2AK2_MOUSE
θ value	8.38298e-14 (rank : 440)	NC score	0.846980 (rank : 219)
Query Neighborhood Hits	1762	Target Neighborhood Hits	864	Shared Neighborhood Hits	825
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

M3K10_HUMAN
θ value	8.38298e-14 (rank : 441)	NC score	0.771901 (rank : 530)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1071	Shared Neighborhood Hits	838
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M4K3_HUMAN
θ value	8.38298e-14 (rank : 442)	NC score	0.833176 (rank : 314)
Query Neighborhood Hits	1762	Target Neighborhood Hits	857	Shared Neighborhood Hits	821
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

MYOTI_HUMAN
θ value	8.38298e-14 (rank : 443)	NC score	0.397300 (rank : 849)
Query Neighborhood Hits	1762	Target Neighborhood Hits	292	Shared Neighborhood Hits	261
SwissProt Accessions	Q9UBF9	Gene names	MYOT, TTID
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein) (57 kDa cytoskeletal protein).

PMYT1_HUMAN
θ value	8.38298e-14 (rank : 444)	NC score	0.829736 (rank : 335)
Query Neighborhood Hits	1762	Target Neighborhood Hits	814	Shared Neighborhood Hits	799
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

GSK3A_HUMAN
θ value	1.09485e-13 (rank : 445)	NC score	0.823601 (rank : 370)
Query Neighborhood Hits	1762	Target Neighborhood Hits	835	Shared Neighborhood Hits	795
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

M3K1_MOUSE
θ value	1.09485e-13 (rank : 446)	NC score	0.853644 (rank : 168)
Query Neighborhood Hits	1762	Target Neighborhood Hits	952	Shared Neighborhood Hits	851
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

M3K4_HUMAN
θ value	1.09485e-13 (rank : 447)	NC score	0.847248 (rank : 217)
Query Neighborhood Hits	1762	Target Neighborhood Hits	911	Shared Neighborhood Hits	833
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

MYO3A_HUMAN
θ value	1.09485e-13 (rank : 448)	NC score	0.727704 (rank : 588)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1033	Shared Neighborhood Hits	836
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

MK04_MOUSE
θ value	1.42992e-13 (rank : 449)	NC score	0.816724 (rank : 402)
Query Neighborhood Hits	1762	Target Neighborhood Hits	852	Shared Neighborhood Hits	812
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

MOK_MOUSE
θ value	1.42992e-13 (rank : 450)	NC score	0.815575 (rank : 405)
Query Neighborhood Hits	1762	Target Neighborhood Hits	796	Shared Neighborhood Hits	788
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

NCA12_HUMAN
θ value	1.42992e-13 (rank : 451)	NC score	0.385372 (rank : 872)
Query Neighborhood Hits	1762	Target Neighborhood Hits	437	Shared Neighborhood Hits	315
SwissProt Accessions	P13592, P13593	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120) (CD56 antigen).

NEK7_MOUSE
θ value	1.42992e-13 (rank : 452)	NC score	0.846687 (rank : 221)
Query Neighborhood Hits	1762	Target Neighborhood Hits	847	Shared Neighborhood Hits	827
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

CDK6_MOUSE
θ value	1.86753e-13 (rank : 453)	NC score	0.825359 (rank : 358)
Query Neighborhood Hits	1762	Target Neighborhood Hits	837	Shared Neighborhood Hits	820
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

MOK_HUMAN
θ value	1.86753e-13 (rank : 454)	NC score	0.817797 (rank : 396)
Query Neighborhood Hits	1762	Target Neighborhood Hits	807	Shared Neighborhood Hits	794
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

ST32B_MOUSE
θ value	1.86753e-13 (rank : 455)	NC score	0.851294 (rank : 193)
Query Neighborhood Hits	1762	Target Neighborhood Hits	828	Shared Neighborhood Hits	816
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

CDK6_HUMAN
θ value	2.43908e-13 (rank : 456)	NC score	0.824878 (rank : 362)
Query Neighborhood Hits	1762	Target Neighborhood Hits	837	Shared Neighborhood Hits	820
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

M3K7_HUMAN
θ value	2.43908e-13 (rank : 457)	NC score	0.787167 (rank : 502)
Query Neighborhood Hits	1762	Target Neighborhood Hits	892	Shared Neighborhood Hits	816
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_MOUSE
θ value	2.43908e-13 (rank : 458)	NC score	0.787263 (rank : 501)
Query Neighborhood Hits	1762	Target Neighborhood Hits	892	Shared Neighborhood Hits	816
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M4K4_MOUSE
θ value	2.43908e-13 (rank : 459)	NC score	0.793984 (rank : 483)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1560	Shared Neighborhood Hits	884
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MYO3A_MOUSE
θ value	2.43908e-13 (rank : 460)	NC score	0.735349 (rank : 576)
Query Neighborhood Hits	1762	Target Neighborhood Hits	902	Shared Neighborhood Hits	820
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

SRMS_MOUSE
θ value	2.43908e-13 (rank : 461)	NC score	0.696124 (rank : 633)
Query Neighborhood Hits	1762	Target Neighborhood Hits	964	Shared Neighborhood Hits	818
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

WNK1_HUMAN
θ value	2.43908e-13 (rank : 462)	NC score	0.801871 (rank : 460)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1158	Shared Neighborhood Hits	877
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

WNK1_MOUSE
θ value	2.43908e-13 (rank : 463)	NC score	0.799244 (rank : 468)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1179	Shared Neighborhood Hits	862
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

CCRK_HUMAN
θ value	3.18553e-13 (rank : 464)	NC score	0.824306 (rank : 368)
Query Neighborhood Hits	1762	Target Neighborhood Hits	835	Shared Neighborhood Hits	819
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

LATS1_HUMAN
θ value	3.18553e-13 (rank : 465)	NC score	0.810659 (rank : 437)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1057	Shared Neighborhood Hits	880
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

MK12_HUMAN
θ value	3.18553e-13 (rank : 466)	NC score	0.821496 (rank : 378)
Query Neighborhood Hits	1762	Target Neighborhood Hits	830	Shared Neighborhood Hits	813
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

NRK_HUMAN
θ value	3.18553e-13 (rank : 467)	NC score	0.820441 (rank : 381)
Query Neighborhood Hits	1762	Target Neighborhood Hits	931	Shared Neighborhood Hits	835
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

OXSR1_HUMAN
θ value	3.18553e-13 (rank : 468)	NC score	0.836831 (rank : 283)
Query Neighborhood Hits	1762	Target Neighborhood Hits	874	Shared Neighborhood Hits	829
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

TESK2_HUMAN
θ value	3.18553e-13 (rank : 469)	NC score	0.789166 (rank : 498)
Query Neighborhood Hits	1762	Target Neighborhood Hits	851	Shared Neighborhood Hits	808
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

VGFR2_HUMAN
θ value	3.18553e-13 (rank : 470)	NC score	0.715199 (rank : 605)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1103	Shared Neighborhood Hits	999
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

CDK10_HUMAN
θ value	4.16044e-13 (rank : 471)	NC score	0.813786 (rank : 415)
Query Neighborhood Hits	1762	Target Neighborhood Hits	831	Shared Neighborhood Hits	818
SwissProt Accessions	Q15131, Q15130	Gene names	CDK10
Domain Architecture
Description	Cell division protein kinase 10 (EC 2.7.11.22) (Serine/threonine- protein kinase PISSLRE).

GSK3B_HUMAN
θ value	4.16044e-13 (rank : 472)	NC score	0.821727 (rank : 377)
Query Neighborhood Hits	1762	Target Neighborhood Hits	801	Shared Neighborhood Hits	791
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_MOUSE
θ value	4.16044e-13 (rank : 473)	NC score	0.821730 (rank : 376)
Query Neighborhood Hits	1762	Target Neighborhood Hits	800	Shared Neighborhood Hits	791
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

MLTK_HUMAN
θ value	4.16044e-13 (rank : 474)	NC score	0.769131 (rank : 539)
Query Neighborhood Hits	1762	Target Neighborhood Hits	911	Shared Neighborhood Hits	816
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

CCRK_MOUSE
θ value	5.43371e-13 (rank : 475)	NC score	0.823770 (rank : 369)
Query Neighborhood Hits	1762	Target Neighborhood Hits	832	Shared Neighborhood Hits	817
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

M4K2_MOUSE
θ value	5.43371e-13 (rank : 476)	NC score	0.829908 (rank : 332)
Query Neighborhood Hits	1762	Target Neighborhood Hits	843	Shared Neighborhood Hits	813
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

NCA11_MOUSE
θ value	5.43371e-13 (rank : 477)	NC score	0.386774 (rank : 868)
Query Neighborhood Hits	1762	Target Neighborhood Hits	661	Shared Neighborhood Hits	426
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

NRK_MOUSE
θ value	5.43371e-13 (rank : 478)	NC score	0.819309 (rank : 387)
Query Neighborhood Hits	1762	Target Neighborhood Hits	899	Shared Neighborhood Hits	833
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

ARAF_MOUSE
θ value	7.09661e-13 (rank : 479)	NC score	0.770913 (rank : 533)
Query Neighborhood Hits	1762	Target Neighborhood Hits	874	Shared Neighborhood Hits	819
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

M3K14_MOUSE
θ value	7.09661e-13 (rank : 480)	NC score	0.843293 (rank : 239)
Query Neighborhood Hits	1762	Target Neighborhood Hits	889	Shared Neighborhood Hits	828
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

MK13_MOUSE
θ value	7.09661e-13 (rank : 481)	NC score	0.818688 (rank : 392)
Query Neighborhood Hits	1762	Target Neighborhood Hits	832	Shared Neighborhood Hits	814
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MP2K1_HUMAN
θ value	7.09661e-13 (rank : 482)	NC score	0.833690 (rank : 308)
Query Neighborhood Hits	1762	Target Neighborhood Hits	826	Shared Neighborhood Hits	813
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_MOUSE
θ value	7.09661e-13 (rank : 483)	NC score	0.833551 (rank : 309)
Query Neighborhood Hits	1762	Target Neighborhood Hits	826	Shared Neighborhood Hits	813
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

TSSK2_MOUSE
θ value	7.09661e-13 (rank : 484)	NC score	0.853283 (rank : 174)
Query Neighborhood Hits	1762	Target Neighborhood Hits	819	Shared Neighborhood Hits	800
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

WNK3_HUMAN
θ value	7.09661e-13 (rank : 485)	NC score	0.806602 (rank : 450)
Query Neighborhood Hits	1762	Target Neighborhood Hits	948	Shared Neighborhood Hits	779
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

M4K2_HUMAN
θ value	9.26847e-13 (rank : 486)	NC score	0.829752 (rank : 333)
Query Neighborhood Hits	1762	Target Neighborhood Hits	850	Shared Neighborhood Hits	819
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

MYO3B_HUMAN
θ value	9.26847e-13 (rank : 487)	NC score	0.723322 (rank : 593)
Query Neighborhood Hits	1762	Target Neighborhood Hits	923	Shared Neighborhood Hits	837
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

RAF1_HUMAN
θ value	9.26847e-13 (rank : 488)	NC score	0.775173 (rank : 522)
Query Neighborhood Hits	1762	Target Neighborhood Hits	886	Shared Neighborhood Hits	824
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAF1_MOUSE
θ value	9.26847e-13 (rank : 489)	NC score	0.775504 (rank : 521)
Query Neighborhood Hits	1762	Target Neighborhood Hits	886	Shared Neighborhood Hits	825
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

TLK1_HUMAN
θ value	9.26847e-13 (rank : 490)	NC score	0.828544 (rank : 344)
Query Neighborhood Hits	1762	Target Neighborhood Hits	967	Shared Neighborhood Hits	771
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

TLK1_MOUSE
θ value	9.26847e-13 (rank : 491)	NC score	0.828625 (rank : 343)
Query Neighborhood Hits	1762	Target Neighborhood Hits	947	Shared Neighborhood Hits	770
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

VGFR1_MOUSE
θ value	9.26847e-13 (rank : 492)	NC score	0.729514 (rank : 586)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1118	Shared Neighborhood Hits	1013
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

BTK_HUMAN
θ value	1.2105e-12 (rank : 493)	NC score	0.693267 (rank : 644)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1026	Shared Neighborhood Hits	818
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

MLTK_MOUSE
θ value	1.2105e-12 (rank : 494)	NC score	0.769346 (rank : 537)
Query Neighborhood Hits	1762	Target Neighborhood Hits	874	Shared Neighborhood Hits	808
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

NCA12_MOUSE
θ value	1.2105e-12 (rank : 495)	NC score	0.382073 (rank : 881)
Query Neighborhood Hits	1762	Target Neighborhood Hits	399	Shared Neighborhood Hits	302
SwissProt Accessions	P13594, Q61950	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120).

BTK_MOUSE
θ value	1.58096e-12 (rank : 496)	NC score	0.692796 (rank : 645)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1017	Shared Neighborhood Hits	818
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

DYRK3_HUMAN
θ value	1.58096e-12 (rank : 497)	NC score	0.801728 (rank : 461)
Query Neighborhood Hits	1762	Target Neighborhood Hits	798	Shared Neighborhood Hits	781
SwissProt Accessions	O43781	Gene names	DYRK3
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1).

WNK4_HUMAN
θ value	1.58096e-12 (rank : 498)	NC score	0.801068 (rank : 462)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1043	Shared Neighborhood Hits	862
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

MK14_HUMAN
θ value	2.0648e-12 (rank : 499)	NC score	0.819238 (rank : 389)
Query Neighborhood Hits	1762	Target Neighborhood Hits	838	Shared Neighborhood Hits	817
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

OXSR1_MOUSE
θ value	2.0648e-12 (rank : 500)	NC score	0.836439 (rank : 284)
Query Neighborhood Hits	1762	Target Neighborhood Hits	865	Shared Neighborhood Hits	827
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

NEK9_HUMAN
θ value	2.69671e-12 (rank : 501)	NC score	0.831423 (rank : 321)
Query Neighborhood Hits	1762	Target Neighborhood Hits	900	Shared Neighborhood Hits	831
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

M3K14_HUMAN
θ value	3.52202e-12 (rank : 502)	NC score	0.845578 (rank : 230)
Query Neighborhood Hits	1762	Target Neighborhood Hits	887	Shared Neighborhood Hits	840
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

M3K9_HUMAN
θ value	3.52202e-12 (rank : 503)	NC score	0.771698 (rank : 531)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1123	Shared Neighborhood Hits	861
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

MYOM2_HUMAN
θ value	3.52202e-12 (rank : 504)	NC score	0.352608 (rank : 905)
Query Neighborhood Hits	1762	Target Neighborhood Hits	341	Shared Neighborhood Hits	267
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

NEK9_MOUSE
θ value	3.52202e-12 (rank : 505)	NC score	0.830981 (rank : 325)
Query Neighborhood Hits	1762	Target Neighborhood Hits	890	Shared Neighborhood Hits	830
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

TESK2_MOUSE
θ value	3.52202e-12 (rank : 506)	NC score	0.789257 (rank : 497)
Query Neighborhood Hits	1762	Target Neighborhood Hits	833	Shared Neighborhood Hits	801
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

ARAF_HUMAN
θ value	4.59992e-12 (rank : 507)	NC score	0.770972 (rank : 532)
Query Neighborhood Hits	1762	Target Neighborhood Hits	924	Shared Neighborhood Hits	831
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

PMYT1_MOUSE
θ value	4.59992e-12 (rank : 508)	NC score	0.833696 (rank : 307)
Query Neighborhood Hits	1762	Target Neighborhood Hits	910	Shared Neighborhood Hits	837
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

WNK4_MOUSE
θ value	4.59992e-12 (rank : 509)	NC score	0.802254 (rank : 459)
Query Neighborhood Hits	1762	Target Neighborhood Hits	961	Shared Neighborhood Hits	823
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

MK04_HUMAN
θ value	6.00763e-12 (rank : 510)	NC score	0.817414 (rank : 397)
Query Neighborhood Hits	1762	Target Neighborhood Hits	837	Shared Neighborhood Hits	816
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

MK14_MOUSE
θ value	6.00763e-12 (rank : 511)	NC score	0.819427 (rank : 385)
Query Neighborhood Hits	1762	Target Neighborhood Hits	838	Shared Neighborhood Hits	817
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

SBK1_HUMAN
θ value	6.00763e-12 (rank : 512)	NC score	0.861230 (rank : 119)
Query Neighborhood Hits	1762	Target Neighborhood Hits	828	Shared Neighborhood Hits	806
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

TLK2_HUMAN
θ value	6.00763e-12 (rank : 513)	NC score	0.827498 (rank : 348)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1044	Shared Neighborhood Hits	790
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

TLK2_MOUSE
θ value	6.00763e-12 (rank : 514)	NC score	0.825192 (rank : 359)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1088	Shared Neighborhood Hits	791
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

VGFR1_HUMAN
θ value	6.00763e-12 (rank : 515)	NC score	0.724516 (rank : 590)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1109	Shared Neighborhood Hits	1011
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

ACK1_HUMAN
θ value	7.84624e-12 (rank : 516)	NC score	0.680214 (rank : 667)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1140	Shared Neighborhood Hits	934
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

M3K11_HUMAN
θ value	7.84624e-12 (rank : 517)	NC score	0.773236 (rank : 525)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1136	Shared Neighborhood Hits	892
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

NEK6_HUMAN
θ value	7.84624e-12 (rank : 518)	NC score	0.849465 (rank : 204)
Query Neighborhood Hits	1762	Target Neighborhood Hits	848	Shared Neighborhood Hits	827
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NEK6_MOUSE
θ value	7.84624e-12 (rank : 519)	NC score	0.849319 (rank : 206)
Query Neighborhood Hits	1762	Target Neighborhood Hits	851	Shared Neighborhood Hits	827
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

TEC_HUMAN
θ value	7.84624e-12 (rank : 520)	NC score	0.701469 (rank : 626)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1006	Shared Neighborhood Hits	814
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

CD2L1_HUMAN
θ value	1.02475e-11 (rank : 521)	NC score	0.796611 (rank : 474)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1467	Shared Neighborhood Hits	872
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

CD2L1_MOUSE
θ value	1.02475e-11 (rank : 522)	NC score	0.796526 (rank : 475)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1463	Shared Neighborhood Hits	870
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

ERN2_HUMAN
θ value	1.02475e-11 (rank : 523)	NC score	0.814228 (rank : 413)
Query Neighborhood Hits	1762	Target Neighborhood Hits	844	Shared Neighborhood Hits	815
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

MK06_HUMAN
θ value	1.02475e-11 (rank : 524)	NC score	0.806884 (rank : 448)
Query Neighborhood Hits	1762	Target Neighborhood Hits	815	Shared Neighborhood Hits	791
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

MK06_MOUSE
θ value	1.02475e-11 (rank : 525)	NC score	0.806639 (rank : 449)
Query Neighborhood Hits	1762	Target Neighborhood Hits	818	Shared Neighborhood Hits	791
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

MOS_MOUSE
θ value	1.02475e-11 (rank : 526)	NC score	0.772902 (rank : 526)
Query Neighborhood Hits	1762	Target Neighborhood Hits	833	Shared Neighborhood Hits	811
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MP2K5_MOUSE
θ value	1.02475e-11 (rank : 527)	NC score	0.831477 (rank : 320)
Query Neighborhood Hits	1762	Target Neighborhood Hits	840	Shared Neighborhood Hits	821
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MYOM1_MOUSE
θ value	1.02475e-11 (rank : 528)	NC score	0.349224 (rank : 911)
Query Neighborhood Hits	1762	Target Neighborhood Hits	415	Shared Neighborhood Hits	299
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

SBK1_MOUSE
θ value	1.02475e-11 (rank : 529)	NC score	0.862746 (rank : 108)
Query Neighborhood Hits	1762	Target Neighborhood Hits	824	Shared Neighborhood Hits	804
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

ACK1_MOUSE
θ value	1.33837e-11 (rank : 530)	NC score	0.678367 (rank : 671)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1080	Shared Neighborhood Hits	918
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

CDON_HUMAN
θ value	1.33837e-11 (rank : 531)	NC score	0.386268 (rank : 870)
Query Neighborhood Hits	1762	Target Neighborhood Hits	412	Shared Neighborhood Hits	295
SwissProt Accessions	Q4KMG0, O14631	Gene names	CDON, CDO
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

WNK2_HUMAN
θ value	1.33837e-11 (rank : 532)	NC score	0.798786 (rank : 471)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1407	Shared Neighborhood Hits	979
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

E2AK2_HUMAN
θ value	1.74796e-11 (rank : 533)	NC score	0.835872 (rank : 289)
Query Neighborhood Hits	1762	Target Neighborhood Hits	856	Shared Neighborhood Hits	815
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

M3K8_HUMAN
θ value	1.74796e-11 (rank : 534)	NC score	0.838598 (rank : 275)
Query Neighborhood Hits	1762	Target Neighborhood Hits	807	Shared Neighborhood Hits	793
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

M3K8_MOUSE
θ value	1.74796e-11 (rank : 535)	NC score	0.838789 (rank : 274)
Query Neighborhood Hits	1762	Target Neighborhood Hits	815	Shared Neighborhood Hits	793
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

LATS2_MOUSE
θ value	2.28291e-11 (rank : 536)	NC score	0.805560 (rank : 454)
Query Neighborhood Hits	1762	Target Neighborhood Hits	879	Shared Neighborhood Hits	822
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

CDK4_HUMAN
θ value	2.98157e-11 (rank : 537)	NC score	0.815299 (rank : 408)
Query Neighborhood Hits	1762	Target Neighborhood Hits	834	Shared Neighborhood Hits	819
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

ERN2_MOUSE
θ value	2.98157e-11 (rank : 538)	NC score	0.811991 (rank : 433)
Query Neighborhood Hits	1762	Target Neighborhood Hits	825	Shared Neighborhood Hits	804
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

MDGA1_HUMAN
θ value	2.98157e-11 (rank : 539)	NC score	0.348158 (rank : 913)
Query Neighborhood Hits	1762	Target Neighborhood Hits	358	Shared Neighborhood Hits	265
SwissProt Accessions	Q8NFP4, Q8NBE3	Gene names	MDGA1, MAMDC3
Domain Architecture
Description	MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor (MAM domain-containing protein 3) (GPI and MAM protein) (Glycosylphosphatidylinositol-MAM) (GPIM).

OPCM_HUMAN
θ value	2.98157e-11 (rank : 540)	NC score	0.362215 (rank : 897)
Query Neighborhood Hits	1762	Target Neighborhood Hits	332	Shared Neighborhood Hits	271
SwissProt Accessions	Q14982	Gene names	OPCML, OBCAM
Domain Architecture
Description	Opioid-binding protein/cell adhesion molecule precursor (OBCAM) (Opioid-binding cell adhesion molecule) (OPCML).

CDK4_MOUSE
θ value	3.89403e-11 (rank : 541)	NC score	0.815425 (rank : 407)
Query Neighborhood Hits	1762	Target Neighborhood Hits	838	Shared Neighborhood Hits	819
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

HIPK4_HUMAN
θ value	3.89403e-11 (rank : 542)	NC score	0.806572 (rank : 451)
Query Neighborhood Hits	1762	Target Neighborhood Hits	799	Shared Neighborhood Hits	783
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

MK13_HUMAN
θ value	3.89403e-11 (rank : 543)	NC score	0.816986 (rank : 398)
Query Neighborhood Hits	1762	Target Neighborhood Hits	829	Shared Neighborhood Hits	814
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MP2K6_HUMAN
θ value	5.08577e-11 (rank : 544)	NC score	0.811796 (rank : 435)
Query Neighborhood Hits	1762	Target Neighborhood Hits	830	Shared Neighborhood Hits	810
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

STK39_HUMAN
θ value	5.08577e-11 (rank : 545)	NC score	0.834925 (rank : 299)
Query Neighborhood Hits	1762	Target Neighborhood Hits	882	Shared Neighborhood Hits	831
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
θ value	5.08577e-11 (rank : 546)	NC score	0.835444 (rank : 295)
Query Neighborhood Hits	1762	Target Neighborhood Hits	915	Shared Neighborhood Hits	839
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

FGFR1_MOUSE
θ value	6.64225e-11 (rank : 547)	NC score	0.757237 (rank : 548)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1068	Shared Neighborhood Hits	1009
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

LATS1_MOUSE
θ value	6.64225e-11 (rank : 548)	NC score	0.807801 (rank : 446)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1027	Shared Neighborhood Hits	869
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

PTPRS_HUMAN
θ value	6.64225e-11 (rank : 549)	NC score	0.272967 (rank : 975)
Query Neighborhood Hits	1762	Target Neighborhood Hits	472	Shared Neighborhood Hits	311
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

RIPK1_HUMAN
θ value	6.64225e-11 (rank : 550)	NC score	0.784036 (rank : 508)
Query Neighborhood Hits	1762	Target Neighborhood Hits	891	Shared Neighborhood Hits	829
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

TEC_MOUSE
θ value	6.64225e-11 (rank : 551)	NC score	0.706511 (rank : 614)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1006	Shared Neighborhood Hits	816
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

CD2L2_HUMAN
θ value	8.67504e-11 (rank : 552)	NC score	0.798883 (rank : 470)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1439	Shared Neighborhood Hits	877
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

DYRK2_HUMAN
θ value	8.67504e-11 (rank : 553)	NC score	0.800795 (rank : 464)
Query Neighborhood Hits	1762	Target Neighborhood Hits	799	Shared Neighborhood Hits	782
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

JAK2_HUMAN
θ value	8.67504e-11 (rank : 554)	NC score	0.741828 (rank : 563)
Query Neighborhood Hits	1762	Target Neighborhood Hits	847	Shared Neighborhood Hits	813
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

MK15_HUMAN
θ value	8.67504e-11 (rank : 555)	NC score	0.824707 (rank : 363)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1038	Shared Neighborhood Hits	884
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

RIPK5_HUMAN
θ value	8.67504e-11 (rank : 556)	NC score	0.798291 (rank : 472)
Query Neighborhood Hits	1762	Target Neighborhood Hits	864	Shared Neighborhood Hits	818
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK5_MOUSE
θ value	8.67504e-11 (rank : 557)	NC score	0.797564 (rank : 473)
Query Neighborhood Hits	1762	Target Neighborhood Hits	874	Shared Neighborhood Hits	819
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

SRMS_HUMAN
θ value	8.67504e-11 (rank : 558)	NC score	0.689740 (rank : 653)
Query Neighborhood Hits	1762	Target Neighborhood Hits	946	Shared Neighborhood Hits	817
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

CHL1_MOUSE
θ value	1.133e-10 (rank : 559)	NC score	0.373186 (rank : 892)
Query Neighborhood Hits	1762	Target Neighborhood Hits	402	Shared Neighborhood Hits	303
SwissProt Accessions	P70232, Q8BS24, Q8C6W0, Q8C823, Q8VBY7	Gene names	Chl1, Call
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Cell adhesion molecule with homology to L1CAM) (Close homolog of L1) (Chl1-like protein).

FAK1_HUMAN
θ value	1.133e-10 (rank : 560)	NC score	0.703435 (rank : 621)
Query Neighborhood Hits	1762	Target Neighborhood Hits	850	Shared Neighborhood Hits	808
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
θ value	1.133e-10 (rank : 561)	NC score	0.703054 (rank : 622)
Query Neighborhood Hits	1762	Target Neighborhood Hits	850	Shared Neighborhood Hits	808
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

JAK2_MOUSE
θ value	1.47974e-10 (rank : 562)	NC score	0.741146 (rank : 565)
Query Neighborhood Hits	1762	Target Neighborhood Hits	839	Shared Neighborhood Hits	808
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

MK11_MOUSE
θ value	1.47974e-10 (rank : 563)	NC score	0.814500 (rank : 411)
Query Neighborhood Hits	1762	Target Neighborhood Hits	835	Shared Neighborhood Hits	818
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

NTRK2_HUMAN
θ value	1.47974e-10 (rank : 564)	NC score	0.733083 (rank : 581)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1081	Shared Neighborhood Hits	960
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
θ value	1.47974e-10 (rank : 565)	NC score	0.733088 (rank : 580)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1088	Shared Neighborhood Hits	960
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

CDON_MOUSE
θ value	1.9326e-10 (rank : 566)	NC score	0.384800 (rank : 875)
Query Neighborhood Hits	1762	Target Neighborhood Hits	410	Shared Neighborhood Hits	302
SwissProt Accessions	Q32MD9, O88971	Gene names	Cdon, Cdo
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

DYRK4_HUMAN
θ value	1.9326e-10 (rank : 567)	NC score	0.786715 (rank : 503)
Query Neighborhood Hits	1762	Target Neighborhood Hits	750	Shared Neighborhood Hits	742
SwissProt Accessions	Q9NR20, Q8NEF2, Q92631	Gene names	DYRK4
Domain Architecture	No domain graphic available
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1).

ERN1_HUMAN
θ value	1.9326e-10 (rank : 568)	NC score	0.816855 (rank : 400)
Query Neighborhood Hits	1762	Target Neighborhood Hits	829	Shared Neighborhood Hits	807
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

RIPK1_MOUSE
θ value	1.9326e-10 (rank : 569)	NC score	0.777004 (rank : 520)
Query Neighborhood Hits	1762	Target Neighborhood Hits	874	Shared Neighborhood Hits	821
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

PIM1_MOUSE
θ value	2.52405e-10 (rank : 570)	NC score	0.837462 (rank : 279)
Query Neighborhood Hits	1762	Target Neighborhood Hits	787	Shared Neighborhood Hits	770
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

TESK1_MOUSE
θ value	2.52405e-10 (rank : 571)	NC score	0.790092 (rank : 496)
Query Neighborhood Hits	1762	Target Neighborhood Hits	862	Shared Neighborhood Hits	812
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

BRAF1_HUMAN
θ value	3.29651e-10 (rank : 572)	NC score	0.774094 (rank : 524)
Query Neighborhood Hits	1762	Target Neighborhood Hits	883	Shared Neighborhood Hits	816
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

ERN1_MOUSE
θ value	3.29651e-10 (rank : 573)	NC score	0.815886 (rank : 404)
Query Neighborhood Hits	1762	Target Neighborhood Hits	823	Shared Neighborhood Hits	807
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

MP2K5_HUMAN
θ value	3.29651e-10 (rank : 574)	NC score	0.825887 (rank : 353)
Query Neighborhood Hits	1762	Target Neighborhood Hits	837	Shared Neighborhood Hits	817
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

PRP4B_HUMAN
θ value	3.29651e-10 (rank : 575)	NC score	0.774517 (rank : 523)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1030	Shared Neighborhood Hits	805
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

PRP4B_MOUSE
θ value	3.29651e-10 (rank : 576)	NC score	0.772698 (rank : 527)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1040	Shared Neighborhood Hits	802
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

HIPK2_HUMAN
θ value	4.30538e-10 (rank : 577)	NC score	0.783120 (rank : 513)
Query Neighborhood Hits	1762	Target Neighborhood Hits	845	Shared Neighborhood Hits	794
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

HIPK2_MOUSE
θ value	4.30538e-10 (rank : 578)	NC score	0.782416 (rank : 514)
Query Neighborhood Hits	1762	Target Neighborhood Hits	871	Shared Neighborhood Hits	800
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

MP2K6_MOUSE
θ value	4.30538e-10 (rank : 579)	NC score	0.812688 (rank : 422)
Query Neighborhood Hits	1762	Target Neighborhood Hits	830	Shared Neighborhood Hits	811
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

FGFR1_HUMAN
θ value	5.62301e-10 (rank : 580)	NC score	0.757111 (rank : 549)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1069	Shared Neighborhood Hits	1012
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

HIPK1_HUMAN
θ value	5.62301e-10 (rank : 581)	NC score	0.783827 (rank : 510)
Query Neighborhood Hits	1762	Target Neighborhood Hits	843	Shared Neighborhood Hits	797
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

HIPK1_MOUSE
θ value	5.62301e-10 (rank : 582)	NC score	0.783492 (rank : 511)
Query Neighborhood Hits	1762	Target Neighborhood Hits	838	Shared Neighborhood Hits	793
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

LRRK2_HUMAN
θ value	5.62301e-10 (rank : 583)	NC score	0.706499 (rank : 615)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1382	Shared Neighborhood Hits	845
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

MK11_HUMAN
θ value	5.62301e-10 (rank : 584)	NC score	0.808206 (rank : 443)
Query Neighborhood Hits	1762	Target Neighborhood Hits	823	Shared Neighborhood Hits	813
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

MYOM1_HUMAN
θ value	5.62301e-10 (rank : 585)	NC score	0.342474 (rank : 915)
Query Neighborhood Hits	1762	Target Neighborhood Hits	405	Shared Neighborhood Hits	283
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

CHL1_HUMAN
θ value	7.34386e-10 (rank : 586)	NC score	0.373312 (rank : 891)
Query Neighborhood Hits	1762	Target Neighborhood Hits	413	Shared Neighborhood Hits	311
SwissProt Accessions	O00533, Q2M3G2, Q59FY0	Gene names	CHL1, CALL
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Close homolog of L1).

GAK_HUMAN
θ value	7.34386e-10 (rank : 587)	NC score	0.793644 (rank : 484)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1028	Shared Neighborhood Hits	863
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

MYBPH_MOUSE
θ value	7.34386e-10 (rank : 588)	NC score	0.326718 (rank : 925)
Query Neighborhood Hits	1762	Target Neighborhood Hits	290	Shared Neighborhood Hits	247
SwissProt Accessions	P70402	Gene names	Mybph
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

CSK21_HUMAN
θ value	9.59137e-10 (rank : 589)	NC score	0.813320 (rank : 418)
Query Neighborhood Hits	1762	Target Neighborhood Hits	772	Shared Neighborhood Hits	764
SwissProt Accessions	P68400, P19138, P20426, Q14013	Gene names	CSNK2A1, CK2A1
Domain Architecture	No domain graphic available
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

CSK21_MOUSE
θ value	9.59137e-10 (rank : 590)	NC score	0.813568 (rank : 416)
Query Neighborhood Hits	1762	Target Neighborhood Hits	770	Shared Neighborhood Hits	763
SwissProt Accessions	Q60737	Gene names	Csnk2a1, Ckiia
Domain Architecture
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

M3KL4_HUMAN
θ value	9.59137e-10 (rank : 591)	NC score	0.760448 (rank : 546)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1087	Shared Neighborhood Hits	830
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

DYR1B_MOUSE
θ value	1.25267e-09 (rank : 592)	NC score	0.794786 (rank : 480)
Query Neighborhood Hits	1762	Target Neighborhood Hits	799	Shared Neighborhood Hits	777
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

HIPK3_HUMAN
θ value	1.25267e-09 (rank : 593)	NC score	0.783828 (rank : 509)
Query Neighborhood Hits	1762	Target Neighborhood Hits	867	Shared Neighborhood Hits	803
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

HIPK3_MOUSE
θ value	1.25267e-09 (rank : 594)	NC score	0.785768 (rank : 504)
Query Neighborhood Hits	1762	Target Neighborhood Hits	857	Shared Neighborhood Hits	802
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

PIM2_HUMAN
θ value	1.25267e-09 (rank : 595)	NC score	0.839896 (rank : 267)
Query Neighborhood Hits	1762	Target Neighborhood Hits	808	Shared Neighborhood Hits	793
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

SN_MOUSE
θ value	1.25267e-09 (rank : 596)	NC score	0.322935 (rank : 926)
Query Neighborhood Hits	1762	Target Neighborhood Hits	416	Shared Neighborhood Hits	275
SwissProt Accessions	Q62230, O55216, Q62228, Q62229	Gene names	Sn, Sa
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (Sheep erythrocyte receptor) (SER) (CD169 antigen).

CSK22_HUMAN
θ value	1.63604e-09 (rank : 597)	NC score	0.807942 (rank : 444)
Query Neighborhood Hits	1762	Target Neighborhood Hits	758	Shared Neighborhood Hits	754
SwissProt Accessions	P19784	Gene names	CSNK2A2, CK2A2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

DYR1B_HUMAN
θ value	1.63604e-09 (rank : 598)	NC score	0.790891 (rank : 489)
Query Neighborhood Hits	1762	Target Neighborhood Hits	831	Shared Neighborhood Hits	785
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

GAK_MOUSE
θ value	1.63604e-09 (rank : 599)	NC score	0.790310 (rank : 494)
Query Neighborhood Hits	1762	Target Neighborhood Hits	964	Shared Neighborhood Hits	830
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

CD22_MOUSE
θ value	2.13673e-09 (rank : 600)	NC score	0.310573 (rank : 935)
Query Neighborhood Hits	1762	Target Neighborhood Hits	331	Shared Neighborhood Hits	226
SwissProt Accessions	P35329, Q9JHL2, Q9JJX9, Q9JJY0, Q9JJY1, Q9R056, Q9R094, Q9WU51	Gene names	Cd22, Lyb-8
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

CLK2_HUMAN
θ value	2.13673e-09 (rank : 601)	NC score	0.760464 (rank : 545)
Query Neighborhood Hits	1762	Target Neighborhood Hits	752	Shared Neighborhood Hits	734
SwissProt Accessions	P49760, Q96CQ0	Gene names	CLK2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

GRK7_HUMAN
θ value	2.13673e-09 (rank : 602)	NC score	0.835653 (rank : 293)
Query Neighborhood Hits	1762	Target Neighborhood Hits	820	Shared Neighborhood Hits	806
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

NFH_MOUSE
θ value	2.13673e-09 (rank : 603)	NC score	0.058178 (rank : 1265)
Query Neighborhood Hits	1762	Target Neighborhood Hits	2247	Shared Neighborhood Hits	476
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

PDK1L_HUMAN
θ value	2.13673e-09 (rank : 604)	NC score	0.840668 (rank : 261)
Query Neighborhood Hits	1762	Target Neighborhood Hits	821	Shared Neighborhood Hits	802
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PDK1L_MOUSE
θ value	2.13673e-09 (rank : 605)	NC score	0.840523 (rank : 262)
Query Neighborhood Hits	1762	Target Neighborhood Hits	821	Shared Neighborhood Hits	803
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PIM1_HUMAN
θ value	2.13673e-09 (rank : 606)	NC score	0.838258 (rank : 278)
Query Neighborhood Hits	1762	Target Neighborhood Hits	797	Shared Neighborhood Hits	781
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

DYR1A_HUMAN
θ value	2.79066e-09 (rank : 607)	NC score	0.780725 (rank : 517)
Query Neighborhood Hits	1762	Target Neighborhood Hits	764	Shared Neighborhood Hits	747
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

DYR1A_MOUSE
θ value	2.79066e-09 (rank : 608)	NC score	0.780761 (rank : 516)
Query Neighborhood Hits	1762	Target Neighborhood Hits	762	Shared Neighborhood Hits	747
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

IRAK4_MOUSE
θ value	2.79066e-09 (rank : 609)	NC score	0.785045 (rank : 506)
Query Neighborhood Hits	1762	Target Neighborhood Hits	820	Shared Neighborhood Hits	794
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

SN_HUMAN
θ value	2.79066e-09 (rank : 610)	NC score	0.319160 (rank : 927)
Query Neighborhood Hits	1762	Target Neighborhood Hits	434	Shared Neighborhood Hits	269
SwissProt Accessions	Q9BZZ2, Q96DL4, Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7	Gene names	SN
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (CD169 antigen).

CD2L6_HUMAN
θ value	3.64472e-09 (rank : 611)	NC score	0.799697 (rank : 467)
Query Neighborhood Hits	1762	Target Neighborhood Hits	844	Shared Neighborhood Hits	815
SwissProt Accessions	Q9BWU1, Q5JQZ7, Q5JR00, Q8TC78, Q9UPX2	Gene names	CDC2L6, CDK11, KIAA1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11).

CD2L6_MOUSE
θ value	3.64472e-09 (rank : 612)	NC score	0.799891 (rank : 466)
Query Neighborhood Hits	1762	Target Neighborhood Hits	851	Shared Neighborhood Hits	819
SwissProt Accessions	Q8BWD8, Q80TM1	Gene names	Cdc2l6, Kiaa1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6).

CSK22_MOUSE
θ value	3.64472e-09 (rank : 613)	NC score	0.807909 (rank : 445)
Query Neighborhood Hits	1762	Target Neighborhood Hits	758	Shared Neighborhood Hits	754
SwissProt Accessions	O54833	Gene names	Csnk2a2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

FES_HUMAN
θ value	3.64472e-09 (rank : 614)	NC score	0.719959 (rank : 598)
Query Neighborhood Hits	1762	Target Neighborhood Hits	978	Shared Neighborhood Hits	799
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGFR2_HUMAN
θ value	3.64472e-09 (rank : 615)	NC score	0.753754 (rank : 554)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1062	Shared Neighborhood Hits	993
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

HCK_HUMAN
θ value	3.64472e-09 (rank : 616)	NC score	0.677229 (rank : 678)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1035	Shared Neighborhood Hits	829
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

MOS_HUMAN
θ value	3.64472e-09 (rank : 617)	NC score	0.772117 (rank : 529)
Query Neighborhood Hits	1762	Target Neighborhood Hits	829	Shared Neighborhood Hits	811
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MP2K7_HUMAN
θ value	3.64472e-09 (rank : 618)	NC score	0.825164 (rank : 360)
Query Neighborhood Hits	1762	Target Neighborhood Hits	833	Shared Neighborhood Hits	808
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

MYBPH_HUMAN
θ value	3.64472e-09 (rank : 619)	NC score	0.328124 (rank : 924)
Query Neighborhood Hits	1762	Target Neighborhood Hits	256	Shared Neighborhood Hits	240
SwissProt Accessions	Q13203, Q16886, Q86YC5	Gene names	MYBPH
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

TXK_MOUSE
θ value	3.64472e-09 (rank : 620)	NC score	0.686763 (rank : 656)
Query Neighborhood Hits	1762	Target Neighborhood Hits	980	Shared Neighborhood Hits	804
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

CD22_HUMAN
θ value	4.76016e-09 (rank : 621)	NC score	0.310795 (rank : 934)
Query Neighborhood Hits	1762	Target Neighborhood Hits	365	Shared Neighborhood Hits	241
SwissProt Accessions	P20273, O95699, O95701, O95702, O95703, Q01665, Q92872, Q92873, Q9UQA6, Q9UQA7, Q9UQA8, Q9UQA9, Q9UQB0, Q9Y2A6	Gene names	CD22
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

LCK_HUMAN
θ value	4.76016e-09 (rank : 622)	NC score	0.678883 (rank : 669)
Query Neighborhood Hits	1762	Target Neighborhood Hits	987	Shared Neighborhood Hits	825
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LRRK2_MOUSE
θ value	4.76016e-09 (rank : 623)	NC score	0.689952 (rank : 652)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1359	Shared Neighborhood Hits	834
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

TESK1_HUMAN
θ value	4.76016e-09 (rank : 624)	NC score	0.788353 (rank : 500)
Query Neighborhood Hits	1762	Target Neighborhood Hits	864	Shared Neighborhood Hits	814
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

BMX_MOUSE
θ value	6.21693e-09 (rank : 625)	NC score	0.695457 (rank : 634)
Query Neighborhood Hits	1762	Target Neighborhood Hits	912	Shared Neighborhood Hits	787
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

CSK_MOUSE
θ value	6.21693e-09 (rank : 626)	NC score	0.702283 (rank : 623)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1009	Shared Neighborhood Hits	822
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

LATS2_HUMAN
θ value	6.21693e-09 (rank : 627)	NC score	0.804606 (rank : 456)
Query Neighborhood Hits	1762	Target Neighborhood Hits	884	Shared Neighborhood Hits	828
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

LIMK1_HUMAN
θ value	6.21693e-09 (rank : 628)	NC score	0.754457 (rank : 552)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1005	Shared Neighborhood Hits	817
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

MK15_MOUSE
θ value	6.21693e-09 (rank : 629)	NC score	0.823122 (rank : 372)
Query Neighborhood Hits	1762	Target Neighborhood Hits	843	Shared Neighborhood Hits	822
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

NEGR1_MOUSE
θ value	6.21693e-09 (rank : 630)	NC score	0.353654 (rank : 904)
Query Neighborhood Hits	1762	Target Neighborhood Hits	349	Shared Neighborhood Hits	261
SwissProt Accessions	Q80Z24, Q3UHQ8, Q80T70	Gene names	Negr1, Kiaa3001, Ntra
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor (Kilon protein) (Kindred of IgLON) (Neurotractin).

PIM2_MOUSE
θ value	6.21693e-09 (rank : 631)	NC score	0.841107 (rank : 255)
Query Neighborhood Hits	1762	Target Neighborhood Hits	809	Shared Neighborhood Hits	793
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

STK16_HUMAN
θ value	6.21693e-09 (rank : 632)	NC score	0.820643 (rank : 379)
Query Neighborhood Hits	1762	Target Neighborhood Hits	824	Shared Neighborhood Hits	810
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

STK16_MOUSE
θ value	6.21693e-09 (rank : 633)	NC score	0.819302 (rank : 388)
Query Neighborhood Hits	1762	Target Neighborhood Hits	824	Shared Neighborhood Hits	804
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

TYK2_HUMAN
θ value	6.21693e-09 (rank : 634)	NC score	0.734436 (rank : 578)
Query Neighborhood Hits	1762	Target Neighborhood Hits	841	Shared Neighborhood Hits	813
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

F5006_MOUSE
θ value	8.11959e-09 (rank : 635)	NC score	0.822903 (rank : 373)
Query Neighborhood Hits	1762	Target Neighborhood Hits	793	Shared Neighborhood Hits	785
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

LCK_MOUSE
θ value	8.11959e-09 (rank : 636)	NC score	0.683350 (rank : 661)
Query Neighborhood Hits	1762	Target Neighborhood Hits	981	Shared Neighborhood Hits	822
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LYN_MOUSE
θ value	8.11959e-09 (rank : 637)	NC score	0.692121 (rank : 646)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1023	Shared Neighborhood Hits	837
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MK09_HUMAN
θ value	8.11959e-09 (rank : 638)	NC score	0.812505 (rank : 424)
Query Neighborhood Hits	1762	Target Neighborhood Hits	842	Shared Neighborhood Hits	820
SwissProt Accessions	P45984, Q15708, Q15710, Q15711, Q8N5C5	Gene names	MAPK9, JNK2, PRKM9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).

RYK_MOUSE
θ value	8.11959e-09 (rank : 639)	NC score	0.557178 (rank : 803)
Query Neighborhood Hits	1762	Target Neighborhood Hits	715	Shared Neighborhood Hits	688
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

TYK2_MOUSE
θ value	8.11959e-09 (rank : 640)	NC score	0.729808 (rank : 583)
Query Neighborhood Hits	1762	Target Neighborhood Hits	850	Shared Neighborhood Hits	814
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

MK09_MOUSE
θ value	1.06045e-08 (rank : 641)	NC score	0.808840 (rank : 440)
Query Neighborhood Hits	1762	Target Neighborhood Hits	843	Shared Neighborhood Hits	819
SwissProt Accessions	Q9WTU6, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5	Gene names	Mapk9, Jnk2, Prkm9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2).

MK10_HUMAN
θ value	1.06045e-08 (rank : 642)	NC score	0.805958 (rank : 453)
Query Neighborhood Hits	1762	Target Neighborhood Hits	836	Shared Neighborhood Hits	816
SwissProt Accessions	P53779, Q15707	Gene names	MAPK10, JNK3, JNK3A, PRKM10
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

MK10_MOUSE
θ value	1.06045e-08 (rank : 643)	NC score	0.805459 (rank : 455)
Query Neighborhood Hits	1762	Target Neighborhood Hits	849	Shared Neighborhood Hits	819
SwissProt Accessions	Q61831, Q9R0U6	Gene names	Mapk10, Jnk3, Prkm10, Serk2
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

MP2K3_HUMAN
θ value	1.06045e-08 (rank : 644)	NC score	0.814814 (rank : 410)
Query Neighborhood Hits	1762	Target Neighborhood Hits	825	Shared Neighborhood Hits	811
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K3_MOUSE
θ value	1.06045e-08 (rank : 645)	NC score	0.815949 (rank : 403)
Query Neighborhood Hits	1762	Target Neighborhood Hits	826	Shared Neighborhood Hits	811
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

PTK6_MOUSE
θ value	1.06045e-08 (rank : 646)	NC score	0.714082 (rank : 607)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1026	Shared Neighborhood Hits	822
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

FES_MOUSE
θ value	1.38499e-08 (rank : 647)	NC score	0.720826 (rank : 595)
Query Neighborhood Hits	1762	Target Neighborhood Hits	980	Shared Neighborhood Hits	802
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

JAK1_HUMAN
θ value	1.38499e-08 (rank : 648)	NC score	0.723727 (rank : 592)
Query Neighborhood Hits	1762	Target Neighborhood Hits	858	Shared Neighborhood Hits	813
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

MATK_MOUSE
θ value	1.38499e-08 (rank : 649)	NC score	0.694720 (rank : 636)
Query Neighborhood Hits	1762	Target Neighborhood Hits	952	Shared Neighborhood Hits	823
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

PIM3_HUMAN
θ value	1.38499e-08 (rank : 650)	NC score	0.837377 (rank : 280)
Query Neighborhood Hits	1762	Target Neighborhood Hits	789	Shared Neighborhood Hits	776
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

TXK_HUMAN
θ value	1.38499e-08 (rank : 651)	NC score	0.698796 (rank : 629)
Query Neighborhood Hits	1762	Target Neighborhood Hits	971	Shared Neighborhood Hits	806
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

VGFR2_MOUSE
θ value	1.38499e-08 (rank : 652)	NC score	0.714781 (rank : 606)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1089	Shared Neighborhood Hits	996
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

VGFR3_MOUSE
θ value	1.38499e-08 (rank : 653)	NC score	0.698154 (rank : 630)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1056	Shared Neighborhood Hits	978
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

CLK2_MOUSE
θ value	1.80886e-08 (rank : 654)	NC score	0.748261 (rank : 558)
Query Neighborhood Hits	1762	Target Neighborhood Hits	743	Shared Neighborhood Hits	728
SwissProt Accessions	O35491	Gene names	Clk2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

LIMK1_MOUSE
θ value	1.80886e-08 (rank : 655)	NC score	0.753471 (rank : 555)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1008	Shared Neighborhood Hits	815
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

LYN_HUMAN
θ value	1.80886e-08 (rank : 656)	NC score	0.690903 (rank : 649)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1022	Shared Neighborhood Hits	834
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

STK35_HUMAN
θ value	1.80886e-08 (rank : 657)	NC score	0.835702 (rank : 292)
Query Neighborhood Hits	1762	Target Neighborhood Hits	825	Shared Neighborhood Hits	806
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

VGFR3_HUMAN
θ value	1.80886e-08 (rank : 658)	NC score	0.694478 (rank : 638)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1037	Shared Neighborhood Hits	972
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

BMX_HUMAN
θ value	2.36244e-08 (rank : 659)	NC score	0.696179 (rank : 632)
Query Neighborhood Hits	1762	Target Neighborhood Hits	942	Shared Neighborhood Hits	796
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

CSK_HUMAN
θ value	2.36244e-08 (rank : 660)	NC score	0.694414 (rank : 639)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1009	Shared Neighborhood Hits	821
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

KC1G1_MOUSE
θ value	2.36244e-08 (rank : 661)	NC score	0.664536 (rank : 714)
Query Neighborhood Hits	1762	Target Neighborhood Hits	713	Shared Neighborhood Hits	703
SwissProt Accessions	Q8BTH8	Gene names	Csnk1g1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

SRC_HUMAN
θ value	2.36244e-08 (rank : 662)	NC score	0.670191 (rank : 695)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1058	Shared Neighborhood Hits	823
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
θ value	2.36244e-08 (rank : 663)	NC score	0.671128 (rank : 692)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1033	Shared Neighborhood Hits	821
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

STK40_HUMAN
θ value	3.08544e-08 (rank : 664)	NC score	0.813215 (rank : 419)
Query Neighborhood Hits	1762	Target Neighborhood Hits	751	Shared Neighborhood Hits	738
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

STK40_MOUSE
θ value	3.08544e-08 (rank : 665)	NC score	0.813052 (rank : 420)
Query Neighborhood Hits	1762	Target Neighborhood Hits	751	Shared Neighborhood Hits	738
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

MATK_HUMAN
θ value	4.0297e-08 (rank : 666)	NC score	0.690267 (rank : 651)
Query Neighborhood Hits	1762	Target Neighborhood Hits	954	Shared Neighborhood Hits	818
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

NTRI_HUMAN
θ value	4.0297e-08 (rank : 667)	NC score	0.353975 (rank : 903)
Query Neighborhood Hits	1762	Target Neighborhood Hits	344	Shared Neighborhood Hits	271
SwissProt Accessions	Q9P121, Q6UXJ3, Q86VJ9	Gene names	NT
Domain Architecture
Description	Neurotrimin precursor (hNT).

NTRI_MOUSE
θ value	4.0297e-08 (rank : 668)	NC score	0.354862 (rank : 901)
Query Neighborhood Hits	1762	Target Neighborhood Hits	342	Shared Neighborhood Hits	271
SwissProt Accessions	Q99PJ0	Gene names	Nt, Hnt
Domain Architecture
Description	Neurotrimin precursor.

ROR2_MOUSE
θ value	4.0297e-08 (rank : 669)	NC score	0.681527 (rank : 666)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1000	Shared Neighborhood Hits	925
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

BLK_MOUSE
θ value	5.26297e-08 (rank : 670)	NC score	0.676329 (rank : 681)
Query Neighborhood Hits	1762	Target Neighborhood Hits	992	Shared Neighborhood Hits	821
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CLK4_MOUSE
θ value	5.26297e-08 (rank : 671)	NC score	0.763430 (rank : 543)
Query Neighborhood Hits	1762	Target Neighborhood Hits	759	Shared Neighborhood Hits	749
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

F5006_HUMAN
θ value	5.26297e-08 (rank : 672)	NC score	0.819119 (rank : 390)
Query Neighborhood Hits	1762	Target Neighborhood Hits	794	Shared Neighborhood Hits	783
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

FGFR4_MOUSE
θ value	5.26297e-08 (rank : 673)	NC score	0.720548 (rank : 596)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1026	Shared Neighborhood Hits	981
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

HCK_MOUSE
θ value	5.26297e-08 (rank : 674)	NC score	0.672325 (rank : 687)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1029	Shared Neighborhood Hits	825
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

JAK3_HUMAN
θ value	5.26297e-08 (rank : 675)	NC score	0.734062 (rank : 579)
Query Neighborhood Hits	1762	Target Neighborhood Hits	827	Shared Neighborhood Hits	802
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

RYK_HUMAN
θ value	5.26297e-08 (rank : 676)	NC score	0.542817 (rank : 813)
Query Neighborhood Hits	1762	Target Neighborhood Hits	701	Shared Neighborhood Hits	677
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

WEE1_HUMAN
θ value	5.26297e-08 (rank : 677)	NC score	0.783270 (rank : 512)
Query Neighborhood Hits	1762	Target Neighborhood Hits	777	Shared Neighborhood Hits	744
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

MAMC1_HUMAN
θ value	6.87365e-08 (rank : 678)	NC score	0.350066 (rank : 908)
Query Neighborhood Hits	1762	Target Neighborhood Hits	357	Shared Neighborhood Hits	269
SwissProt Accessions	Q7Z553	Gene names	MAMDC1, MDGA2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

MASTL_HUMAN
θ value	6.87365e-08 (rank : 679)	NC score	0.827974 (rank : 346)
Query Neighborhood Hits	1762	Target Neighborhood Hits	894	Shared Neighborhood Hits	824
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

NEGR1_HUMAN
θ value	6.87365e-08 (rank : 680)	NC score	0.354098 (rank : 902)
Query Neighborhood Hits	1762	Target Neighborhood Hits	346	Shared Neighborhood Hits	260
SwissProt Accessions	Q7Z3B1, Q5VT21, Q6UY06, Q8NAQ3	Gene names	NEGR1
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor.

ROR2_HUMAN
θ value	6.87365e-08 (rank : 681)	NC score	0.702139 (rank : 624)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1014	Shared Neighborhood Hits	945
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

CLK4_HUMAN
θ value	8.97725e-08 (rank : 682)	NC score	0.764548 (rank : 542)
Query Neighborhood Hits	1762	Target Neighborhood Hits	759	Shared Neighborhood Hits	751
SwissProt Accessions	Q9HAZ1	Gene names	CLK4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

FGR_HUMAN
θ value	8.97725e-08 (rank : 683)	NC score	0.661479 (rank : 723)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1067	Shared Neighborhood Hits	828
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FGR_MOUSE
θ value	8.97725e-08 (rank : 684)	NC score	0.658515 (rank : 730)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1069	Shared Neighborhood Hits	825
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FRK_HUMAN
θ value	8.97725e-08 (rank : 685)	NC score	0.691371 (rank : 648)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1058	Shared Neighborhood Hits	829
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

ITK_MOUSE
θ value	8.97725e-08 (rank : 686)	NC score	0.694670 (rank : 637)
Query Neighborhood Hits	1762	Target Neighborhood Hits	985	Shared Neighborhood Hits	814
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

MASTL_MOUSE
θ value	8.97725e-08 (rank : 687)	NC score	0.827671 (rank : 347)
Query Neighborhood Hits	1762	Target Neighborhood Hits	862	Shared Neighborhood Hits	825
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

MK08_HUMAN
θ value	8.97725e-08 (rank : 688)	NC score	0.806232 (rank : 452)
Query Neighborhood Hits	1762	Target Neighborhood Hits	834	Shared Neighborhood Hits	815
SwissProt Accessions	P45983, Q15709, Q15712, Q15713	Gene names	MAPK8, JNK1, PRKM8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46).

MK08_MOUSE
θ value	8.97725e-08 (rank : 689)	NC score	0.806886 (rank : 447)
Query Neighborhood Hits	1762	Target Neighborhood Hits	834	Shared Neighborhood Hits	815
SwissProt Accessions	Q91Y86	Gene names	Mapk8, Jnk1, Prkm8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1).

VCAM1_MOUSE
θ value	8.97725e-08 (rank : 690)	NC score	0.339383 (rank : 917)
Query Neighborhood Hits	1762	Target Neighborhood Hits	320	Shared Neighborhood Hits	246
SwissProt Accessions	P29533	Gene names	Vcam1, Vcam-1
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1).

ZAP70_MOUSE
θ value	8.97725e-08 (rank : 691)	NC score	0.703574 (rank : 620)
Query Neighborhood Hits	1762	Target Neighborhood Hits	905	Shared Neighborhood Hits	807
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

CDK8_HUMAN
θ value	1.17247e-07 (rank : 692)	NC score	0.796449 (rank : 476)
Query Neighborhood Hits	1762	Target Neighborhood Hits	831	Shared Neighborhood Hits	809
SwissProt Accessions	P49336	Gene names	CDK8
Domain Architecture
Description	Cell division protein kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Protein kinase K35).

FGFR2_MOUSE
θ value	1.17247e-07 (rank : 693)	NC score	0.750413 (rank : 557)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1062	Shared Neighborhood Hits	991
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

KC1G1_HUMAN
θ value	1.17247e-07 (rank : 694)	NC score	0.662524 (rank : 717)
Query Neighborhood Hits	1762	Target Neighborhood Hits	708	Shared Neighborhood Hits	701
SwissProt Accessions	Q9HCP0, Q96AE9, Q9HCP1	Gene names	CSNK1G1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

KIRR2_HUMAN
θ value	1.17247e-07 (rank : 695)	NC score	0.314062 (rank : 930)
Query Neighborhood Hits	1762	Target Neighborhood Hits	321	Shared Neighborhood Hits	236
SwissProt Accessions	Q6UWL6, Q6P1R1, Q7Z5P1, Q7Z5P2, Q96IQ8, Q9H0T1	Gene names	KIRREL2, NEPH3
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3).

MAMC1_MOUSE
θ value	1.17247e-07 (rank : 696)	NC score	0.349424 (rank : 910)
Query Neighborhood Hits	1762	Target Neighborhood Hits	357	Shared Neighborhood Hits	269
SwissProt Accessions	P60755	Gene names	Mamdc1, Mdga2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

PIM3_MOUSE
θ value	1.17247e-07 (rank : 697)	NC score	0.835326 (rank : 297)
Query Neighborhood Hits	1762	Target Neighborhood Hits	783	Shared Neighborhood Hits	770
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

RON_HUMAN
θ value	1.17247e-07 (rank : 698)	NC score	0.659037 (rank : 728)
Query Neighborhood Hits	1762	Target Neighborhood Hits	842	Shared Neighborhood Hits	792
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

CLK1_MOUSE
θ value	1.53129e-07 (rank : 699)	NC score	0.769330 (rank : 538)
Query Neighborhood Hits	1762	Target Neighborhood Hits	760	Shared Neighborhood Hits	749
SwissProt Accessions	P22518	Gene names	Clk1, Clk, Sty
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY).

FER_HUMAN
θ value	1.53129e-07 (rank : 700)	NC score	0.700678 (rank : 627)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1278	Shared Neighborhood Hits	806
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

KC1G3_HUMAN
θ value	1.53129e-07 (rank : 701)	NC score	0.659091 (rank : 727)
Query Neighborhood Hits	1762	Target Neighborhood Hits	711	Shared Neighborhood Hits	706
SwissProt Accessions	Q9Y6M4, Q86WZ7, Q9Y6M3	Gene names	CSNK1G3
Domain Architecture
Description	Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma 3).

MP2K4_HUMAN
θ value	1.53129e-07 (rank : 702)	NC score	0.818186 (rank : 394)
Query Neighborhood Hits	1762	Target Neighborhood Hits	832	Shared Neighborhood Hits	812
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K4_MOUSE
θ value	1.53129e-07 (rank : 703)	NC score	0.818161 (rank : 395)
Query Neighborhood Hits	1762	Target Neighborhood Hits	833	Shared Neighborhood Hits	812
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

WEE1B_HUMAN
θ value	1.53129e-07 (rank : 704)	NC score	0.765946 (rank : 541)
Query Neighborhood Hits	1762	Target Neighborhood Hits	836	Shared Neighborhood Hits	747
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

WEE1B_MOUSE
θ value	1.53129e-07 (rank : 705)	NC score	0.763119 (rank : 544)
Query Neighborhood Hits	1762	Target Neighborhood Hits	765	Shared Neighborhood Hits	731
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

CLK1_HUMAN
θ value	1.99992e-07 (rank : 706)	NC score	0.769111 (rank : 540)
Query Neighborhood Hits	1762	Target Neighborhood Hits	756	Shared Neighborhood Hits	742
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

LRRK1_MOUSE
θ value	1.99992e-07 (rank : 707)	NC score	0.718751 (rank : 599)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1267	Shared Neighborhood Hits	836
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

TRIB2_HUMAN
θ value	1.99992e-07 (rank : 708)	NC score	0.770423 (rank : 534)
Query Neighborhood Hits	1762	Target Neighborhood Hits	657	Shared Neighborhood Hits	649
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

EPHA1_HUMAN
θ value	2.61198e-07 (rank : 709)	NC score	0.652446 (rank : 734)
Query Neighborhood Hits	1762	Target Neighborhood Hits	997	Shared Neighborhood Hits	842
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHA1_MOUSE
θ value	2.61198e-07 (rank : 710)	NC score	0.644070 (rank : 749)
Query Neighborhood Hits	1762	Target Neighborhood Hits	958	Shared Neighborhood Hits	835
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHB3_HUMAN
θ value	2.61198e-07 (rank : 711)	NC score	0.660899 (rank : 725)
Query Neighborhood Hits	1762	Target Neighborhood Hits	996	Shared Neighborhood Hits	870
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHB3_MOUSE
θ value	2.61198e-07 (rank : 712)	NC score	0.659664 (rank : 726)
Query Neighborhood Hits	1762	Target Neighborhood Hits	996	Shared Neighborhood Hits	870
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

FGFR3_HUMAN
θ value	2.61198e-07 (rank : 713)	NC score	0.746795 (rank : 560)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1042	Shared Neighborhood Hits	995
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

IRAK4_HUMAN
θ value	2.61198e-07 (rank : 714)	NC score	0.779179 (rank : 519)
Query Neighborhood Hits	1762	Target Neighborhood Hits	816	Shared Neighborhood Hits	795
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

ITK_HUMAN
θ value	2.61198e-07 (rank : 715)	NC score	0.694184 (rank : 640)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1016	Shared Neighborhood Hits	818
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

TNK1_HUMAN
θ value	2.61198e-07 (rank : 716)	NC score	0.676668 (rank : 679)
Query Neighborhood Hits	1762	Target Neighborhood Hits	815	Shared Neighborhood Hits	776
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

CI094_HUMAN
θ value	3.41135e-07 (rank : 717)	NC score	0.277590 (rank : 968)
Query Neighborhood Hits	1762	Target Neighborhood Hits	310	Shared Neighborhood Hits	229
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

ROR1_MOUSE
θ value	3.41135e-07 (rank : 718)	NC score	0.713567 (rank : 608)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1025	Shared Neighborhood Hits	966
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

FYN_HUMAN
θ value	4.45536e-07 (rank : 719)	NC score	0.675551 (rank : 682)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1078	Shared Neighborhood Hits	833
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

JAK3_MOUSE
θ value	4.45536e-07 (rank : 720)	NC score	0.739044 (rank : 569)
Query Neighborhood Hits	1762	Target Neighborhood Hits	821	Shared Neighborhood Hits	795
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

LIMK2_MOUSE
θ value	4.45536e-07 (rank : 721)	NC score	0.754120 (rank : 553)
Query Neighborhood Hits	1762	Target Neighborhood Hits	998	Shared Neighborhood Hits	807
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LRRK1_HUMAN
θ value	4.45536e-07 (rank : 722)	NC score	0.720266 (rank : 597)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1237	Shared Neighborhood Hits	830
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

TRIB2_MOUSE
θ value	4.45536e-07 (rank : 723)	NC score	0.769807 (rank : 535)
Query Neighborhood Hits	1762	Target Neighborhood Hits	653	Shared Neighborhood Hits	645
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

YES_HUMAN
θ value	4.45536e-07 (rank : 724)	NC score	0.666613 (rank : 705)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1059	Shared Neighborhood Hits	824
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ZAP70_HUMAN
θ value	4.45536e-07 (rank : 725)	NC score	0.705466 (rank : 618)
Query Neighborhood Hits	1762	Target Neighborhood Hits	893	Shared Neighborhood Hits	802
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

E2AK3_MOUSE
θ value	5.81887e-07 (rank : 726)	NC score	0.808737 (rank : 441)
Query Neighborhood Hits	1762	Target Neighborhood Hits	851	Shared Neighborhood Hits	825
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

JAK1_MOUSE
θ value	5.81887e-07 (rank : 727)	NC score	0.716470 (rank : 603)
Query Neighborhood Hits	1762	Target Neighborhood Hits	854	Shared Neighborhood Hits	811
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

KC1G2_HUMAN
θ value	5.81887e-07 (rank : 728)	NC score	0.633468 (rank : 759)
Query Neighborhood Hits	1762	Target Neighborhood Hits	693	Shared Neighborhood Hits	687
SwissProt Accessions	P78368, O00704, Q8WUB1	Gene names	CSNK1G2
Domain Architecture
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

LIMK2_HUMAN
θ value	5.81887e-07 (rank : 729)	NC score	0.756964 (rank : 550)
Query Neighborhood Hits	1762	Target Neighborhood Hits	986	Shared Neighborhood Hits	808
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

MUC1_HUMAN
θ value	5.81887e-07 (rank : 730)	NC score	0.060030 (rank : 1252)
Query Neighborhood Hits	1762	Target Neighborhood Hits	975	Shared Neighborhood Hits	301
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

NPHN_HUMAN
θ value	5.81887e-07 (rank : 731)	NC score	0.339233 (rank : 918)
Query Neighborhood Hits	1762	Target Neighborhood Hits	362	Shared Neighborhood Hits	265
SwissProt Accessions	O60500	Gene names	NPHS1, NPHN
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

NPHN_MOUSE
θ value	5.81887e-07 (rank : 732)	NC score	0.332016 (rank : 920)
Query Neighborhood Hits	1762	Target Neighborhood Hits	370	Shared Neighborhood Hits	265
SwissProt Accessions	Q9QZS7	Gene names	Nphs1, Nphn
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

RIPK3_HUMAN
θ value	5.81887e-07 (rank : 733)	NC score	0.756556 (rank : 551)
Query Neighborhood Hits	1762	Target Neighborhood Hits	828	Shared Neighborhood Hits	796
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

RON_MOUSE
θ value	5.81887e-07 (rank : 734)	NC score	0.648099 (rank : 746)
Query Neighborhood Hits	1762	Target Neighborhood Hits	836	Shared Neighborhood Hits	784
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ROR1_HUMAN
θ value	5.81887e-07 (rank : 735)	NC score	0.711982 (rank : 609)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1018	Shared Neighborhood Hits	960
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

VCAM1_HUMAN
θ value	5.81887e-07 (rank : 736)	NC score	0.337130 (rank : 919)
Query Neighborhood Hits	1762	Target Neighborhood Hits	352	Shared Neighborhood Hits	245
SwissProt Accessions	P19320, Q6NUP8	Gene names	VCAM1, L1CAM
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1) (CD106 antigen) (INCAM-100).

YES_MOUSE
θ value	5.81887e-07 (rank : 737)	NC score	0.665926 (rank : 707)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1052	Shared Neighborhood Hits	819
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FGFR4_HUMAN
θ value	7.59969e-07 (rank : 738)	NC score	0.739512 (rank : 568)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1037	Shared Neighborhood Hits	994
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

KSYK_MOUSE
θ value	7.59969e-07 (rank : 739)	NC score	0.705704 (rank : 616)
Query Neighborhood Hits	1762	Target Neighborhood Hits	944	Shared Neighborhood Hits	810
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

WEE1_MOUSE
θ value	7.59969e-07 (rank : 740)	NC score	0.792844 (rank : 486)
Query Neighborhood Hits	1762	Target Neighborhood Hits	794	Shared Neighborhood Hits	759
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

E2AK1_MOUSE
θ value	9.92553e-07 (rank : 741)	NC score	0.813547 (rank : 417)
Query Neighborhood Hits	1762	Target Neighborhood Hits	821	Shared Neighborhood Hits	803
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

FGFR3_MOUSE
θ value	9.92553e-07 (rank : 742)	NC score	0.747241 (rank : 559)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1059	Shared Neighborhood Hits	1000
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

TNK1_MOUSE
θ value	9.92553e-07 (rank : 743)	NC score	0.684149 (rank : 660)
Query Neighborhood Hits	1762	Target Neighborhood Hits	806	Shared Neighborhood Hits	770
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

TRIB1_HUMAN
θ value	9.92553e-07 (rank : 744)	NC score	0.741936 (rank : 562)
Query Neighborhood Hits	1762	Target Neighborhood Hits	598	Shared Neighborhood Hits	587
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

BLK_HUMAN
θ value	1.29631e-06 (rank : 745)	NC score	0.677719 (rank : 674)
Query Neighborhood Hits	1762	Target Neighborhood Hits	994	Shared Neighborhood Hits	823
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

DDR2_HUMAN
θ value	1.29631e-06 (rank : 746)	NC score	0.641266 (rank : 750)
Query Neighborhood Hits	1762	Target Neighborhood Hits	818	Shared Neighborhood Hits	763
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

E2AK3_HUMAN
θ value	1.29631e-06 (rank : 747)	NC score	0.810457 (rank : 439)
Query Neighborhood Hits	1762	Target Neighborhood Hits	859	Shared Neighborhood Hits	818
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

FYN_MOUSE
θ value	1.29631e-06 (rank : 748)	NC score	0.670500 (rank : 693)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1073	Shared Neighborhood Hits	834
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

KC1G2_MOUSE
θ value	1.29631e-06 (rank : 749)	NC score	0.634543 (rank : 758)
Query Neighborhood Hits	1762	Target Neighborhood Hits	695	Shared Neighborhood Hits	687
SwissProt Accessions	Q8BVP5	Gene names	Csnk1g2
Domain Architecture	No domain graphic available
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

NTRK1_HUMAN
θ value	1.29631e-06 (rank : 750)	NC score	0.664978 (rank : 709)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1023	Shared Neighborhood Hits	877
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

PTK6_HUMAN
θ value	1.29631e-06 (rank : 751)	NC score	0.715910 (rank : 604)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1020	Shared Neighborhood Hits	822
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

EPHA2_MOUSE
θ value	2.21117e-06 (rank : 752)	NC score	0.664118 (rank : 715)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1020	Shared Neighborhood Hits	860
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

PGFRB_HUMAN
θ value	2.21117e-06 (rank : 753)	NC score	0.654602 (rank : 732)
Query Neighborhood Hits	1762	Target Neighborhood Hits	962	Shared Neighborhood Hits	915
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

STYK1_MOUSE
θ value	2.21117e-06 (rank : 754)	NC score	0.647905 (rank : 747)
Query Neighborhood Hits	1762	Target Neighborhood Hits	779	Shared Neighborhood Hits	753
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

CLK3_HUMAN
θ value	2.88788e-06 (rank : 755)	NC score	0.737960 (rank : 572)
Query Neighborhood Hits	1762	Target Neighborhood Hits	748	Shared Neighborhood Hits	733
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK3_MOUSE
θ value	2.88788e-06 (rank : 756)	NC score	0.737332 (rank : 573)
Query Neighborhood Hits	1762	Target Neighborhood Hits	761	Shared Neighborhood Hits	734
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

MDC1_HUMAN
θ value	2.88788e-06 (rank : 757)	NC score	0.084663 (rank : 1146)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1446	Shared Neighborhood Hits	386
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

EPHA2_HUMAN
θ value	3.77169e-06 (rank : 758)	NC score	0.666764 (rank : 704)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1021	Shared Neighborhood Hits	868
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

ROBO4_MOUSE
θ value	3.77169e-06 (rank : 759)	NC score	0.358741 (rank : 898)
Query Neighborhood Hits	1762	Target Neighborhood Hits	358	Shared Neighborhood Hits	271
SwissProt Accessions	Q8C310, Q9DBW1	Gene names	Robo4
Domain Architecture
Description	Roundabout homolog 4 precursor.

TRIB1_MOUSE
θ value	3.77169e-06 (rank : 760)	NC score	0.740393 (rank : 566)
Query Neighborhood Hits	1762	Target Neighborhood Hits	593	Shared Neighborhood Hits	585
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

E2AK1_HUMAN
θ value	4.92598e-06 (rank : 761)	NC score	0.808690 (rank : 442)
Query Neighborhood Hits	1762	Target Neighborhood Hits	833	Shared Neighborhood Hits	806
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

EPHA4_HUMAN
θ value	4.92598e-06 (rank : 762)	NC score	0.664956 (rank : 710)
Query Neighborhood Hits	1762	Target Neighborhood Hits	975	Shared Neighborhood Hits	865
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
θ value	4.92598e-06 (rank : 763)	NC score	0.665910 (rank : 708)
Query Neighborhood Hits	1762	Target Neighborhood Hits	982	Shared Neighborhood Hits	867
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA7_HUMAN
θ value	4.92598e-06 (rank : 764)	NC score	0.677694 (rank : 675)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1053	Shared Neighborhood Hits	873
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

RAGE_MOUSE
θ value	4.92598e-06 (rank : 765)	NC score	0.306865 (rank : 940)
Query Neighborhood Hits	1762	Target Neighborhood Hits	295	Shared Neighborhood Hits	218
SwissProt Accessions	Q62151	Gene names	Ager, Rage
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

ROBO4_HUMAN
θ value	4.92598e-06 (rank : 766)	NC score	0.355185 (rank : 900)
Query Neighborhood Hits	1762	Target Neighborhood Hits	364	Shared Neighborhood Hits	284
SwissProt Accessions	Q8WZ75, Q8TEG1, Q96JV6, Q9H718, Q9NWJ8	Gene names	ROBO4
Domain Architecture
Description	Roundabout homolog 4 precursor (Magic roundabout).

VRK1_MOUSE
θ value	4.92598e-06 (rank : 767)	NC score	0.493186 (rank : 818)
Query Neighborhood Hits	1762	Target Neighborhood Hits	583	Shared Neighborhood Hits	574
SwissProt Accessions	Q80X41, O88635, O88636, Q8C2P7, Q91YH9	Gene names	Vrk1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) (Serine/threonine-protein kinase 51PK).

DDR2_MOUSE
θ value	6.43352e-06 (rank : 768)	NC score	0.646901 (rank : 748)
Query Neighborhood Hits	1762	Target Neighborhood Hits	813	Shared Neighborhood Hits	763
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

EPHA7_MOUSE
θ value	6.43352e-06 (rank : 769)	NC score	0.677393 (rank : 677)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1025	Shared Neighborhood Hits	872
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHB1_HUMAN
θ value	6.43352e-06 (rank : 770)	NC score	0.679031 (rank : 668)
Query Neighborhood Hits	1762	Target Neighborhood Hits	988	Shared Neighborhood Hits	861
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

INSR_MOUSE
θ value	6.43352e-06 (rank : 771)	NC score	0.650586 (rank : 738)
Query Neighborhood Hits	1762	Target Neighborhood Hits	968	Shared Neighborhood Hits	826
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

KSYK_HUMAN
θ value	6.43352e-06 (rank : 772)	NC score	0.705472 (rank : 617)
Query Neighborhood Hits	1762	Target Neighborhood Hits	901	Shared Neighborhood Hits	797
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

RET_HUMAN
θ value	6.43352e-06 (rank : 773)	NC score	0.672620 (rank : 686)
Query Neighborhood Hits	1762	Target Neighborhood Hits	873	Shared Neighborhood Hits	792
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

ATL3_HUMAN
θ value	8.40245e-06 (rank : 774)	NC score	0.212254 (rank : 1006)
Query Neighborhood Hits	1762	Target Neighborhood Hits	414	Shared Neighborhood Hits	261
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

CI096_HUMAN
θ value	8.40245e-06 (rank : 775)	NC score	0.801017 (rank : 463)
Query Neighborhood Hits	1762	Target Neighborhood Hits	821	Shared Neighborhood Hits	796
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

KIRR3_MOUSE
θ value	8.40245e-06 (rank : 776)	NC score	0.292618 (rank : 948)
Query Neighborhood Hits	1762	Target Neighborhood Hits	292	Shared Neighborhood Hits	221
SwissProt Accessions	Q8BR86, Q6P555, Q810H3, Q8BGQ5, Q8BRS8	Gene names	Kirrel3, Kiaa1867
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3).

LTK_HUMAN
θ value	8.40245e-06 (rank : 777)	NC score	0.604293 (rank : 784)
Query Neighborhood Hits	1762	Target Neighborhood Hits	774	Shared Neighborhood Hits	740
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

PINK1_HUMAN
θ value	8.40245e-06 (rank : 778)	NC score	0.730085 (rank : 582)
Query Neighborhood Hits	1762	Target Neighborhood Hits	741	Shared Neighborhood Hits	716
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

SIG11_HUMAN
θ value	8.40245e-06 (rank : 779)	NC score	0.279603 (rank : 964)
Query Neighborhood Hits	1762	Target Neighborhood Hits	273	Shared Neighborhood Hits	232
SwissProt Accessions	Q96RL6	Gene names	SIGLEC11
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 11 precursor (Siglec-11) (Sialic acid-binding lectin 11).

TIE2_HUMAN
θ value	8.40245e-06 (rank : 780)	NC score	0.694048 (rank : 641)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1192	Shared Neighborhood Hits	888
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

ICAM5_MOUSE
θ value	1.09739e-05 (rank : 781)	NC score	0.297582 (rank : 943)
Query Neighborhood Hits	1762	Target Neighborhood Hits	308	Shared Neighborhood Hits	234
SwissProt Accessions	Q60625	Gene names	Icam5, Tlcn
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

KIRR3_HUMAN
θ value	1.09739e-05 (rank : 782)	NC score	0.294437 (rank : 947)
Query Neighborhood Hits	1762	Target Neighborhood Hits	302	Shared Neighborhood Hits	227
SwissProt Accessions	Q8IZU9, Q6UWJ9, Q6UWL5, Q96JG0	Gene names	KIRREL3, KIAA1867, NEPH2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3) (Nephrin-like 2).

NTRK3_HUMAN
θ value	1.09739e-05 (rank : 783)	NC score	0.701778 (rank : 625)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1115	Shared Neighborhood Hits	946
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

TIE2_MOUSE
θ value	1.09739e-05 (rank : 784)	NC score	0.693820 (rank : 642)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1204	Shared Neighborhood Hits	889
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

TYRO3_HUMAN
θ value	1.09739e-05 (rank : 785)	NC score	0.711721 (rank : 610)
Query Neighborhood Hits	1762	Target Neighborhood Hits	995	Shared Neighborhood Hits	934
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

TYRO3_MOUSE
θ value	1.09739e-05 (rank : 786)	NC score	0.710630 (rank : 611)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1007	Shared Neighborhood Hits	939
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

AAK1_HUMAN
θ value	1.43324e-05 (rank : 787)	NC score	0.790563 (rank : 491)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1077	Shared Neighborhood Hits	909
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

AAK1_MOUSE
θ value	1.43324e-05 (rank : 788)	NC score	0.788835 (rank : 499)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1051	Shared Neighborhood Hits	885
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

ALK_HUMAN
θ value	1.43324e-05 (rank : 789)	NC score	0.612545 (rank : 778)
Query Neighborhood Hits	1762	Target Neighborhood Hits	795	Shared Neighborhood Hits	732
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

AVR2B_HUMAN
θ value	1.43324e-05 (rank : 790)	NC score	0.636625 (rank : 756)
Query Neighborhood Hits	1762	Target Neighborhood Hits	748	Shared Neighborhood Hits	729
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AVR2B_MOUSE
θ value	1.43324e-05 (rank : 791)	NC score	0.636755 (rank : 754)
Query Neighborhood Hits	1762	Target Neighborhood Hits	749	Shared Neighborhood Hits	729
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

INSR_HUMAN
θ value	1.43324e-05 (rank : 792)	NC score	0.650946 (rank : 736)
Query Neighborhood Hits	1762	Target Neighborhood Hits	963	Shared Neighborhood Hits	833
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

MET_MOUSE
θ value	1.43324e-05 (rank : 793)	NC score	0.651897 (rank : 735)
Query Neighborhood Hits	1762	Target Neighborhood Hits	844	Shared Neighborhood Hits	786
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

AVR2A_HUMAN
θ value	1.87187e-05 (rank : 794)	NC score	0.650208 (rank : 741)
Query Neighborhood Hits	1762	Target Neighborhood Hits	767	Shared Neighborhood Hits	750
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

AVR2A_MOUSE
θ value	1.87187e-05 (rank : 795)	NC score	0.650224 (rank : 740)
Query Neighborhood Hits	1762	Target Neighborhood Hits	767	Shared Neighborhood Hits	750
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

BMP2K_HUMAN
θ value	1.87187e-05 (rank : 796)	NC score	0.790201 (rank : 495)
Query Neighborhood Hits	1762	Target Neighborhood Hits	867	Shared Neighborhood Hits	788
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

BMP2K_MOUSE
θ value	1.87187e-05 (rank : 797)	NC score	0.791788 (rank : 487)
Query Neighborhood Hits	1762	Target Neighborhood Hits	874	Shared Neighborhood Hits	786
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

EPHA3_HUMAN
θ value	1.87187e-05 (rank : 798)	NC score	0.676552 (rank : 680)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1005	Shared Neighborhood Hits	883
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA5_HUMAN
θ value	1.87187e-05 (rank : 799)	NC score	0.670287 (rank : 694)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1009	Shared Neighborhood Hits	870
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHA5_MOUSE
θ value	1.87187e-05 (rank : 800)	NC score	0.682146 (rank : 664)
Query Neighborhood Hits	1762	Target Neighborhood Hits	950	Shared Neighborhood Hits	857
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

PGFRB_MOUSE
θ value	1.87187e-05 (rank : 801)	NC score	0.658574 (rank : 729)
Query Neighborhood Hits	1762	Target Neighborhood Hits	960	Shared Neighborhood Hits	911
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

RIPK2_HUMAN
θ value	1.87187e-05 (rank : 802)	NC score	0.707394 (rank : 613)
Query Neighborhood Hits	1762	Target Neighborhood Hits	774	Shared Neighborhood Hits	740
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RIPK2_MOUSE
θ value	1.87187e-05 (rank : 803)	NC score	0.705336 (rank : 619)
Query Neighborhood Hits	1762	Target Neighborhood Hits	776	Shared Neighborhood Hits	740
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

SIG10_HUMAN
θ value	1.87187e-05 (rank : 804)	NC score	0.274081 (rank : 973)
Query Neighborhood Hits	1762	Target Neighborhood Hits	363	Shared Neighborhood Hits	261
SwissProt Accessions	Q96LC7, Q6UXI8, Q96G54, Q96LC8	Gene names	SIGLEC10, SLG2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 10 precursor (Siglec-10) (Siglec- like protein 2).

EPHA8_MOUSE
θ value	2.44474e-05 (rank : 805)	NC score	0.661830 (rank : 720)
Query Neighborhood Hits	1762	Target Neighborhood Hits	969	Shared Neighborhood Hits	864
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

FA47B_HUMAN
θ value	2.44474e-05 (rank : 806)	NC score	0.055568 (rank : 1281)
Query Neighborhood Hits	1762	Target Neighborhood Hits	431	Shared Neighborhood Hits	147
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

MET_HUMAN
θ value	2.44474e-05 (rank : 807)	NC score	0.649809 (rank : 742)
Query Neighborhood Hits	1762	Target Neighborhood Hits	831	Shared Neighborhood Hits	782
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

PGFRA_HUMAN
θ value	2.44474e-05 (rank : 808)	NC score	0.669002 (rank : 699)
Query Neighborhood Hits	1762	Target Neighborhood Hits	980	Shared Neighborhood Hits	925
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRA_MOUSE
θ value	2.44474e-05 (rank : 809)	NC score	0.666229 (rank : 706)
Query Neighborhood Hits	1762	Target Neighborhood Hits	975	Shared Neighborhood Hits	922
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PINK1_MOUSE
θ value	2.44474e-05 (rank : 810)	NC score	0.734775 (rank : 577)
Query Neighborhood Hits	1762	Target Neighborhood Hits	726	Shared Neighborhood Hits	713
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

RGS3_MOUSE
θ value	2.44474e-05 (rank : 811)	NC score	0.066794 (rank : 1222)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1621	Shared Neighborhood Hits	444
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

RIPK3_MOUSE
θ value	2.44474e-05 (rank : 812)	NC score	0.759296 (rank : 547)
Query Neighborhood Hits	1762	Target Neighborhood Hits	867	Shared Neighborhood Hits	809
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

STYK1_HUMAN
θ value	2.44474e-05 (rank : 813)	NC score	0.661573 (rank : 721)
Query Neighborhood Hits	1762	Target Neighborhood Hits	786	Shared Neighborhood Hits	760
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

FAK2_HUMAN
θ value	3.19293e-05 (rank : 814)	NC score	0.685532 (rank : 658)
Query Neighborhood Hits	1762	Target Neighborhood Hits	847	Shared Neighborhood Hits	785
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_MOUSE
θ value	3.19293e-05 (rank : 815)	NC score	0.690451 (rank : 650)
Query Neighborhood Hits	1762	Target Neighborhood Hits	851	Shared Neighborhood Hits	788
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

RAGE_HUMAN
θ value	3.19293e-05 (rank : 816)	NC score	0.316283 (rank : 929)
Query Neighborhood Hits	1762	Target Neighborhood Hits	269	Shared Neighborhood Hits	227
SwissProt Accessions	Q15109, Q15279, Q9H2X7, Q9Y3R3	Gene names	AGER, RAGE
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

RET_MOUSE
θ value	3.19293e-05 (rank : 817)	NC score	0.671380 (rank : 691)
Query Neighborhood Hits	1762	Target Neighborhood Hits	884	Shared Neighborhood Hits	792
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

ALK_MOUSE
θ value	4.1701e-05 (rank : 818)	NC score	0.610317 (rank : 780)
Query Neighborhood Hits	1762	Target Neighborhood Hits	811	Shared Neighborhood Hits	743
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ERBB2_MOUSE
θ value	4.1701e-05 (rank : 819)	NC score	0.653616 (rank : 733)
Query Neighborhood Hits	1762	Target Neighborhood Hits	918	Shared Neighborhood Hits	816
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

FSTL4_HUMAN
θ value	4.1701e-05 (rank : 820)	NC score	0.312156 (rank : 932)
Query Neighborhood Hits	1762	Target Neighborhood Hits	344	Shared Neighborhood Hits	264
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

LRFN3_HUMAN
θ value	4.1701e-05 (rank : 821)	NC score	0.177786 (rank : 1022)
Query Neighborhood Hits	1762	Target Neighborhood Hits	444	Shared Neighborhood Hits	213
SwissProt Accessions	Q9BTN0, Q6UY10	Gene names	LRFN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

SPR1A_MOUSE
θ value	4.1701e-05 (rank : 822)	NC score	0.047760 (rank : 1334)
Query Neighborhood Hits	1762	Target Neighborhood Hits	343	Shared Neighborhood Hits	108
SwissProt Accessions	Q62266	Gene names	Sprr1a
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein 1A) (SPR1A) (SPR1 A).

SPR1B_MOUSE
θ value	4.1701e-05 (rank : 823)	NC score	0.055990 (rank : 1279)
Query Neighborhood Hits	1762	Target Neighborhood Hits	395	Shared Neighborhood Hits	138
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

VSIG2_HUMAN
θ value	4.1701e-05 (rank : 824)	NC score	0.272729 (rank : 978)
Query Neighborhood Hits	1762	Target Neighborhood Hits	321	Shared Neighborhood Hits	219
SwissProt Accessions	Q96IQ7, O95791, Q9NX42	Gene names	VSIG2, CTH, CTXL
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

EPHB2_HUMAN
θ value	5.44631e-05 (rank : 825)	NC score	0.662513 (rank : 718)
Query Neighborhood Hits	1762	Target Neighborhood Hits	983	Shared Neighborhood Hits	855
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	5.44631e-05 (rank : 826)	NC score	0.662718 (rank : 716)
Query Neighborhood Hits	1762	Target Neighborhood Hits	982	Shared Neighborhood Hits	855
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

ERBB2_HUMAN
θ value	5.44631e-05 (rank : 827)	NC score	0.650936 (rank : 737)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1073	Shared Neighborhood Hits	849
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB3_HUMAN
θ value	5.44631e-05 (rank : 828)	NC score	0.623455 (rank : 767)
Query Neighborhood Hits	1762	Target Neighborhood Hits	918	Shared Neighborhood Hits	772
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

KIT_HUMAN
θ value	5.44631e-05 (rank : 829)	NC score	0.650397 (rank : 739)
Query Neighborhood Hits	1762	Target Neighborhood Hits	953	Shared Neighborhood Hits	909
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

SIGL8_HUMAN
θ value	5.44631e-05 (rank : 830)	NC score	0.191263 (rank : 1012)
Query Neighborhood Hits	1762	Target Neighborhood Hits	252	Shared Neighborhood Hits	213
SwissProt Accessions	Q9NYZ4, Q7Z728	Gene names	SIGLEC8, SAF2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 8 precursor (Siglec-8) (Sialoadhesin family member 2) (SAF-2) (CDw329 antigen).

TRIB3_MOUSE
θ value	5.44631e-05 (rank : 831)	NC score	0.729530 (rank : 585)
Query Neighborhood Hits	1762	Target Neighborhood Hits	578	Shared Neighborhood Hits	571
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

VRK1_HUMAN
θ value	5.44631e-05 (rank : 832)	NC score	0.487707 (rank : 820)
Query Neighborhood Hits	1762	Target Neighborhood Hits	584	Shared Neighborhood Hits	573
SwissProt Accessions	Q99986	Gene names	VRK1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1).

KSR2_HUMAN
θ value	7.1131e-05 (rank : 833)	NC score	0.752949 (rank : 556)
Query Neighborhood Hits	1762	Target Neighborhood Hits	920	Shared Neighborhood Hits	840
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

LRFN3_MOUSE
θ value	7.1131e-05 (rank : 834)	NC score	0.185089 (rank : 1018)
Query Neighborhood Hits	1762	Target Neighborhood Hits	455	Shared Neighborhood Hits	220
SwissProt Accessions	Q8BLY3	Gene names	Lrfn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

LRFN4_MOUSE
θ value	7.1131e-05 (rank : 835)	NC score	0.187895 (rank : 1015)
Query Neighborhood Hits	1762	Target Neighborhood Hits	442	Shared Neighborhood Hits	214
SwissProt Accessions	Q80XU8, Q3TQG8, Q8K3C4	Gene names	Lrfn4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

MAG_MOUSE
θ value	7.1131e-05 (rank : 836)	NC score	0.329118 (rank : 922)
Query Neighborhood Hits	1762	Target Neighborhood Hits	271	Shared Neighborhood Hits	238
SwissProt Accessions	P20917, P16880	Gene names	Mag
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

SCYL2_HUMAN
θ value	7.1131e-05 (rank : 837)	NC score	0.618705 (rank : 771)
Query Neighborhood Hits	1762	Target Neighborhood Hits	632	Shared Neighborhood Hits	564
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

EPHA8_HUMAN
θ value	9.29e-05 (rank : 838)	NC score	0.664765 (rank : 712)
Query Neighborhood Hits	1762	Target Neighborhood Hits	956	Shared Neighborhood Hits	864
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

IGF1R_HUMAN
θ value	9.29e-05 (rank : 839)	NC score	0.631401 (rank : 762)
Query Neighborhood Hits	1762	Target Neighborhood Hits	977	Shared Neighborhood Hits	823
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGF1R_MOUSE
θ value	9.29e-05 (rank : 840)	NC score	0.633314 (rank : 760)
Query Neighborhood Hits	1762	Target Neighborhood Hits	973	Shared Neighborhood Hits	822
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

INSRR_MOUSE
θ value	9.29e-05 (rank : 841)	NC score	0.635597 (rank : 757)
Query Neighborhood Hits	1762	Target Neighborhood Hits	961	Shared Neighborhood Hits	811
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

KIT_MOUSE
θ value	9.29e-05 (rank : 842)	NC score	0.649638 (rank : 743)
Query Neighborhood Hits	1762	Target Neighborhood Hits	949	Shared Neighborhood Hits	913
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

LTK_MOUSE
θ value	9.29e-05 (rank : 843)	NC score	0.609419 (rank : 781)
Query Neighborhood Hits	1762	Target Neighborhood Hits	770	Shared Neighborhood Hits	732
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

MAGE1_HUMAN
θ value	9.29e-05 (rank : 844)	NC score	0.054332 (rank : 1292)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1389	Shared Neighborhood Hits	402
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

SCYL2_MOUSE
θ value	9.29e-05 (rank : 845)	NC score	0.598892 (rank : 789)
Query Neighborhood Hits	1762	Target Neighborhood Hits	603	Shared Neighborhood Hits	541
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

TIE1_HUMAN
θ value	9.29e-05 (rank : 846)	NC score	0.678079 (rank : 673)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1241	Shared Neighborhood Hits	908
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE1_MOUSE
θ value	9.29e-05 (rank : 847)	NC score	0.683061 (rank : 662)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1266	Shared Neighborhood Hits	923
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

ANKK1_MOUSE
θ value	0.000121331 (rank : 848)	NC score	0.598233 (rank : 790)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1072	Shared Neighborhood Hits	788
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

EPHB4_HUMAN
θ value	0.000121331 (rank : 849)	NC score	0.668678 (rank : 700)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1056	Shared Neighborhood Hits	867
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

EPHB4_MOUSE
θ value	0.000121331 (rank : 850)	NC score	0.673150 (rank : 685)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1013	Shared Neighborhood Hits	861
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

ERBB3_MOUSE
θ value	0.000121331 (rank : 851)	NC score	0.627125 (rank : 765)
Query Neighborhood Hits	1762	Target Neighborhood Hits	898	Shared Neighborhood Hits	773
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

KIRR2_MOUSE
θ value	0.000121331 (rank : 852)	NC score	0.307128 (rank : 938)
Query Neighborhood Hits	1762	Target Neighborhood Hits	326	Shared Neighborhood Hits	237
SwissProt Accessions	Q7TSU7, Q7TQ98	Gene names	Kirrel2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2).

LRFN5_MOUSE
θ value	0.000121331 (rank : 853)	NC score	0.173730 (rank : 1028)
Query Neighborhood Hits	1762	Target Neighborhood Hits	472	Shared Neighborhood Hits	225
SwissProt Accessions	Q8BXA0, Q8BJH4, Q8BZL0	Gene names	Lrfn5
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

MAG_HUMAN
θ value	0.000121331 (rank : 854)	NC score	0.328422 (rank : 923)
Query Neighborhood Hits	1762	Target Neighborhood Hits	278	Shared Neighborhood Hits	239
SwissProt Accessions	P20916	Gene names	MAG
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

TULP4_HUMAN
θ value	0.000121331 (rank : 855)	NC score	0.035923 (rank : 1409)
Query Neighborhood Hits	1762	Target Neighborhood Hits	426	Shared Neighborhood Hits	100
SwissProt Accessions	Q9NRJ4, Q9HD22, Q9P2F0	Gene names	TULP4, KIAA1397, TUSP
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

ABL1_HUMAN
θ value	0.000158464 (rank : 856)	NC score	0.693678 (rank : 643)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1220	Shared Neighborhood Hits	896
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

CSF1R_MOUSE
θ value	0.000158464 (rank : 857)	NC score	0.638315 (rank : 751)
Query Neighborhood Hits	1762	Target Neighborhood Hits	983	Shared Neighborhood Hits	927
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

KSR1_HUMAN
θ value	0.000158464 (rank : 858)	NC score	0.716780 (rank : 601)
Query Neighborhood Hits	1762	Target Neighborhood Hits	867	Shared Neighborhood Hits	793
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

RPKL1_HUMAN
θ value	0.000158464 (rank : 859)	NC score	0.696817 (rank : 631)
Query Neighborhood Hits	1762	Target Neighborhood Hits	708	Shared Neighborhood Hits	660
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

TRIB3_HUMAN
θ value	0.000158464 (rank : 860)	NC score	0.707849 (rank : 612)
Query Neighborhood Hits	1762	Target Neighborhood Hits	519	Shared Neighborhood Hits	514
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

TTBK2_HUMAN
θ value	0.000158464 (rank : 861)	NC score	0.678367 (rank : 672)
Query Neighborhood Hits	1762	Target Neighborhood Hits	822	Shared Neighborhood Hits	734
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

UHMK1_HUMAN
θ value	0.000158464 (rank : 862)	NC score	0.785751 (rank : 505)
Query Neighborhood Hits	1762	Target Neighborhood Hits	808	Shared Neighborhood Hits	764
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

UHMK1_MOUSE
θ value	0.000158464 (rank : 863)	NC score	0.784619 (rank : 507)
Query Neighborhood Hits	1762	Target Neighborhood Hits	809	Shared Neighborhood Hits	764
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

ABL1_MOUSE
θ value	0.00020696 (rank : 864)	NC score	0.695433 (rank : 635)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1178	Shared Neighborhood Hits	895
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

CSF1R_HUMAN
θ value	0.00020696 (rank : 865)	NC score	0.621704 (rank : 769)
Query Neighborhood Hits	1762	Target Neighborhood Hits	943	Shared Neighborhood Hits	898
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

FSTL4_MOUSE
θ value	0.00020696 (rank : 866)	NC score	0.306879 (rank : 939)
Query Neighborhood Hits	1762	Target Neighborhood Hits	333	Shared Neighborhood Hits	255
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

KSR1_MOUSE
θ value	0.00020696 (rank : 867)	NC score	0.725904 (rank : 589)
Query Neighborhood Hits	1762	Target Neighborhood Hits	870	Shared Neighborhood Hits	806
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

LRFN5_HUMAN
θ value	0.00020696 (rank : 868)	NC score	0.169977 (rank : 1033)
Query Neighborhood Hits	1762	Target Neighborhood Hits	464	Shared Neighborhood Hits	221
SwissProt Accessions	Q96NI6, Q86XL2	Gene names	LRFN5, C14orf146
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

ABL2_HUMAN
θ value	0.000270298 (rank : 869)	NC score	0.689078 (rank : 654)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1045	Shared Neighborhood Hits	826
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

CDC7_MOUSE
θ value	0.000270298 (rank : 870)	NC score	0.682832 (rank : 663)
Query Neighborhood Hits	1762	Target Neighborhood Hits	641	Shared Neighborhood Hits	629
SwissProt Accessions	Q9Z0H0, Q9Z2Y7	Gene names	Cdc7, Cdc7l1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (muCdc7).

IWS1_HUMAN
θ value	0.000270298 (rank : 871)	NC score	0.040334 (rank : 1372)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1241	Shared Neighborhood Hits	224
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

TTBK1_HUMAN
θ value	0.000270298 (rank : 872)	NC score	0.691617 (rank : 647)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1058	Shared Neighborhood Hits	814
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

TTBK2_MOUSE
θ value	0.000270298 (rank : 873)	NC score	0.674898 (rank : 683)
Query Neighborhood Hits	1762	Target Neighborhood Hits	811	Shared Neighborhood Hits	720
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

AATK_MOUSE
θ value	0.00035302 (rank : 874)	NC score	0.636627 (rank : 755)
Query Neighborhood Hits	1762	Target Neighborhood Hits	942	Shared Neighborhood Hits	814
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

FLT3_HUMAN
θ value	0.00035302 (rank : 875)	NC score	0.614065 (rank : 776)
Query Neighborhood Hits	1762	Target Neighborhood Hits	843	Shared Neighborhood Hits	819
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

FLT3_MOUSE
θ value	0.00035302 (rank : 876)	NC score	0.618880 (rank : 770)
Query Neighborhood Hits	1762	Target Neighborhood Hits	847	Shared Neighborhood Hits	826
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

FSTL5_MOUSE
θ value	0.00035302 (rank : 877)	NC score	0.302999 (rank : 942)
Query Neighborhood Hits	1762	Target Neighborhood Hits	355	Shared Neighborhood Hits	255
SwissProt Accessions	Q8BFR2, Q80TG3, Q8C4T3	Gene names	Fstl5, Kiaa1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5) (m- D/Bsp120I 1-2).

KAZD1_MOUSE
θ value	0.00035302 (rank : 878)	NC score	0.282914 (rank : 959)
Query Neighborhood Hits	1762	Target Neighborhood Hits	281	Shared Neighborhood Hits	202
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

BUB1_MOUSE
θ value	0.000461057 (rank : 879)	NC score	0.580203 (rank : 800)
Query Neighborhood Hits	1762	Target Neighborhood Hits	583	Shared Neighborhood Hits	540
SwissProt Accessions	O08901, O09007	Gene names	Bub1
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (MBUB1) (BUB1A).

EGLN1_MOUSE
θ value	0.000461057 (rank : 880)	NC score	0.020721 (rank : 1538)
Query Neighborhood Hits	1762	Target Neighborhood Hits	88	Shared Neighborhood Hits	32
SwissProt Accessions	Q91YE3, Q8VHJ2, Q922P3	Gene names	Egln1
Domain Architecture
Description	Egl nine homolog 1 (EC 1.14.11.-) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-prolyl hydroxylase 2) (HIF-PH2) (HPH-2) (SM-20).

EPHA6_HUMAN
θ value	0.000461057 (rank : 881)	NC score	0.611103 (rank : 779)
Query Neighborhood Hits	1762	Target Neighborhood Hits	959	Shared Neighborhood Hits	847
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA6_MOUSE
θ value	0.000461057 (rank : 882)	NC score	0.612841 (rank : 777)
Query Neighborhood Hits	1762	Target Neighborhood Hits	946	Shared Neighborhood Hits	842
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

ERBB4_HUMAN
θ value	0.000461057 (rank : 883)	NC score	0.662351 (rank : 719)
Query Neighborhood Hits	1762	Target Neighborhood Hits	910	Shared Neighborhood Hits	801
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

INSRR_HUMAN
θ value	0.000461057 (rank : 884)	NC score	0.632462 (rank : 761)
Query Neighborhood Hits	1762	Target Neighborhood Hits	950	Shared Neighborhood Hits	809
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

JAM2_HUMAN
θ value	0.000461057 (rank : 885)	NC score	0.281437 (rank : 960)
Query Neighborhood Hits	1762	Target Neighborhood Hits	304	Shared Neighborhood Hits	244
SwissProt Accessions	P57087, Q6UXG6, Q6YNC1	Gene names	JAM2, C21orf43, VEJAM
Domain Architecture
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

LRC24_HUMAN
θ value	0.000461057 (rank : 886)	NC score	0.134216 (rank : 1071)
Query Neighborhood Hits	1762	Target Neighborhood Hits	404	Shared Neighborhood Hits	193
SwissProt Accessions	Q50LG9	Gene names	LRRC24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

LRFN2_MOUSE
θ value	0.000461057 (rank : 887)	NC score	0.185755 (rank : 1017)
Query Neighborhood Hits	1762	Target Neighborhood Hits	450	Shared Neighborhood Hits	220
SwissProt Accessions	Q80TG9, Q9CYK3	Gene names	Lrfn2, Kiaa1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

MERTK_MOUSE
θ value	0.000461057 (rank : 888)	NC score	0.678508 (rank : 670)
Query Neighborhood Hits	1762	Target Neighborhood Hits	974	Shared Neighborhood Hits	897
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MUC18_MOUSE
θ value	0.000461057 (rank : 889)	NC score	0.285345 (rank : 956)
Query Neighborhood Hits	1762	Target Neighborhood Hits	292	Shared Neighborhood Hits	215
SwissProt Accessions	Q8R2Y2, Q9EPF1, Q9ESS7, Q9JHQ2, Q9JHQ3	Gene names	Mcam, Muc18
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Gicerin).

SON_HUMAN
θ value	0.000461057 (rank : 890)	NC score	0.068079 (rank : 1213)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1568	Shared Neighborhood Hits	406
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

CEA20_HUMAN
θ value	0.000602161 (rank : 891)	NC score	0.261786 (rank : 986)
Query Neighborhood Hits	1762	Target Neighborhood Hits	251	Shared Neighborhood Hits	195
SwissProt Accessions	Q6UY09	Gene names	CEACAM20
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 20 precursor.

EGFR_HUMAN
θ value	0.000602161 (rank : 892)	NC score	0.661017 (rank : 724)
Query Neighborhood Hits	1762	Target Neighborhood Hits	939	Shared Neighborhood Hits	799
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EGFR_MOUSE
θ value	0.000602161 (rank : 893)	NC score	0.661566 (rank : 722)
Query Neighborhood Hits	1762	Target Neighborhood Hits	927	Shared Neighborhood Hits	806
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EPHA3_MOUSE
θ value	0.000602161 (rank : 894)	NC score	0.670191 (rank : 696)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1009	Shared Neighborhood Hits	890
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

FSTL5_HUMAN
θ value	0.000602161 (rank : 895)	NC score	0.307796 (rank : 936)
Query Neighborhood Hits	1762	Target Neighborhood Hits	347	Shared Neighborhood Hits	258
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

LRFN4_HUMAN
θ value	0.000602161 (rank : 896)	NC score	0.189352 (rank : 1014)
Query Neighborhood Hits	1762	Target Neighborhood Hits	462	Shared Neighborhood Hits	222
SwissProt Accessions	Q6PJG9, Q9BWJ0	Gene names	LRFN4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

VRK2_HUMAN
θ value	0.000602161 (rank : 897)	NC score	0.485646 (rank : 821)
Query Neighborhood Hits	1762	Target Neighborhood Hits	582	Shared Neighborhood Hits	559
SwissProt Accessions	Q86Y07, Q49AK9, Q53EU9, Q86Y08, Q86Y09, Q86Y10, Q86Y11, Q86Y12, Q8IXI5, Q99987	Gene names	VRK2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

ANKK1_HUMAN
θ value	0.000786445 (rank : 898)	NC score	0.586981 (rank : 796)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1075	Shared Neighborhood Hits	786
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

E2AK4_HUMAN
θ value	0.000786445 (rank : 899)	NC score	0.794168 (rank : 481)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1012	Shared Neighborhood Hits	836
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

GUC2F_HUMAN
θ value	0.000786445 (rank : 900)	NC score	0.513069 (rank : 816)
Query Neighborhood Hits	1762	Target Neighborhood Hits	740	Shared Neighborhood Hits	665
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

KC1AL_HUMAN
θ value	0.000786445 (rank : 901)	NC score	0.669424 (rank : 698)
Query Neighborhood Hits	1762	Target Neighborhood Hits	734	Shared Neighborhood Hits	723
SwissProt Accessions	Q8N752	Gene names	CSNK1A1L
Domain Architecture
Description	Casein kinase I isoform alpha-like (EC 2.7.11.1) (CKI-alpha-like) (CK1).

LRFN2_HUMAN
θ value	0.000786445 (rank : 902)	NC score	0.185835 (rank : 1016)
Query Neighborhood Hits	1762	Target Neighborhood Hits	450	Shared Neighborhood Hits	216
SwissProt Accessions	Q9ULH4, Q5SYP9	Gene names	LRFN2, KIAA1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

ROS_HUMAN
θ value	0.000786445 (rank : 903)	NC score	0.670076 (rank : 697)
Query Neighborhood Hits	1762	Target Neighborhood Hits	907	Shared Neighborhood Hits	823
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

TMIGD_MOUSE
θ value	0.000786445 (rank : 904)	NC score	0.307135 (rank : 937)
Query Neighborhood Hits	1762	Target Neighborhood Hits	234	Shared Neighborhood Hits	212
SwissProt Accessions	Q9D7L8, Q8R202	Gene names	Tmigd
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

TXND2_HUMAN
θ value	0.000786445 (rank : 905)	NC score	0.057865 (rank : 1272)
Query Neighborhood Hits	1762	Target Neighborhood Hits	793	Shared Neighborhood Hits	216
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

DDR1_MOUSE
θ value	0.00102713 (rank : 906)	NC score	0.617706 (rank : 772)
Query Neighborhood Hits	1762	Target Neighborhood Hits	818	Shared Neighborhood Hits	762
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

E2AK4_MOUSE
θ value	0.00102713 (rank : 907)	NC score	0.790580 (rank : 490)
Query Neighborhood Hits	1762	Target Neighborhood Hits	984	Shared Neighborhood Hits	834
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

EPHAA_HUMAN
θ value	0.00102713 (rank : 908)	NC score	0.555841 (rank : 804)
Query Neighborhood Hits	1762	Target Neighborhood Hits	960	Shared Neighborhood Hits	784
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

IGS4B_MOUSE
θ value	0.00102713 (rank : 909)	NC score	0.272865 (rank : 976)
Query Neighborhood Hits	1762	Target Neighborhood Hits	328	Shared Neighborhood Hits	230
SwissProt Accessions	Q99N28, Q8BSQ8, Q8K1H8	Gene names	Igsf4b, Necl1, Syncam3, Tsll1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (Necl-1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3).

K1683_HUMAN
θ value	0.00102713 (rank : 910)	NC score	0.050628 (rank : 1313)
Query Neighborhood Hits	1762	Target Neighborhood Hits	240	Shared Neighborhood Hits	94
SwissProt Accessions	Q9H0B3, Q8N4G8, Q96M14, Q9C0I0	Gene names	KIAA1683
Domain Architecture	No domain graphic available
Description	Protein KIAA1683.

KC1D_HUMAN
θ value	0.00102713 (rank : 911)	NC score	0.667874 (rank : 703)
Query Neighborhood Hits	1762	Target Neighborhood Hits	737	Shared Neighborhood Hits	723
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
θ value	0.00102713 (rank : 912)	NC score	0.667885 (rank : 702)
Query Neighborhood Hits	1762	Target Neighborhood Hits	737	Shared Neighborhood Hits	723
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1E_HUMAN
θ value	0.00102713 (rank : 913)	NC score	0.664782 (rank : 711)
Query Neighborhood Hits	1762	Target Neighborhood Hits	732	Shared Neighborhood Hits	722
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1E_MOUSE
θ value	0.00102713 (rank : 914)	NC score	0.664757 (rank : 713)
Query Neighborhood Hits	1762	Target Neighborhood Hits	728	Shared Neighborhood Hits	721
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

NIPBL_HUMAN
θ value	0.00102713 (rank : 915)	NC score	0.042668 (rank : 1358)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1311	Shared Neighborhood Hits	243
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

TNI3K_HUMAN
θ value	0.00102713 (rank : 916)	NC score	0.648678 (rank : 744)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1084	Shared Neighborhood Hits	792
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

CIC_HUMAN
θ value	0.00134147 (rank : 917)	NC score	0.059620 (rank : 1254)
Query Neighborhood Hits	1762	Target Neighborhood Hits	992	Shared Neighborhood Hits	340
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

DDR1_HUMAN
θ value	0.00134147 (rank : 918)	NC score	0.615484 (rank : 773)
Query Neighborhood Hits	1762	Target Neighborhood Hits	819	Shared Neighborhood Hits	763
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

KAZD1_HUMAN
θ value	0.00134147 (rank : 919)	NC score	0.257781 (rank : 988)
Query Neighborhood Hits	1762	Target Neighborhood Hits	248	Shared Neighborhood Hits	168
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

KC1A_HUMAN
θ value	0.00134147 (rank : 920)	NC score	0.672224 (rank : 689)
Query Neighborhood Hits	1762	Target Neighborhood Hits	728	Shared Neighborhood Hits	724
SwissProt Accessions	P48729, Q96HD2	Gene names	CSNK1A1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1A_MOUSE
θ value	0.00134147 (rank : 921)	NC score	0.672224 (rank : 690)
Query Neighborhood Hits	1762	Target Neighborhood Hits	728	Shared Neighborhood Hits	724
SwissProt Accessions	Q8BK63, Q3UIL0, Q64506, Q80XI2, Q99LY3	Gene names	Csnk1a1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

LRC21_MOUSE
θ value	0.00134147 (rank : 922)	NC score	0.173784 (rank : 1026)
Query Neighborhood Hits	1762	Target Neighborhood Hits	462	Shared Neighborhood Hits	225
SwissProt Accessions	Q8K099, Q8BXN3	Gene names	Lrrc21, Pal
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

MERTK_HUMAN
θ value	0.00134147 (rank : 923)	NC score	0.673476 (rank : 684)
Query Neighborhood Hits	1762	Target Neighborhood Hits	988	Shared Neighborhood Hits	915
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

NRG1_HUMAN
θ value	0.00134147 (rank : 924)	NC score	0.194704 (rank : 1010)
Query Neighborhood Hits	1762	Target Neighborhood Hits	285	Shared Neighborhood Hits	168
SwissProt Accessions	Q02297, O14667, P98202, Q02298, Q02299, Q07110, Q07111, Q12779, Q12780, Q12781, Q12782, Q12783, Q12784, Q7RTV9, Q7RTW0, Q7RTW1, Q7RTW2, Q8NFN1, Q8NFN2, Q8NFN3, Q9UPE3	Gene names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Domain Architecture
Description	Pro-neuregulin-1, membrane-bound isoform precursor (Pro-NRG1) [Contains: Neuregulin-1 (Neu differentiation factor) (Heregulin) (HRG) (Breast cancer cell differentiation factor p45) (Acetylcholine receptor-inducing activity) (ARIA) (Sensory and motor neuron-derived factor) (Glial growth factor)].

SRPK2_HUMAN
θ value	0.00134147 (rank : 925)	NC score	0.545755 (rank : 808)
Query Neighborhood Hits	1762	Target Neighborhood Hits	664	Shared Neighborhood Hits	574
SwissProt Accessions	P78362, O75220, O75221, Q6NUL0, Q6V1X2, Q8IYQ3	Gene names	SRPK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

SRPK2_MOUSE
θ value	0.00134147 (rank : 926)	NC score	0.543187 (rank : 811)
Query Neighborhood Hits	1762	Target Neighborhood Hits	765	Shared Neighborhood Hits	586
SwissProt Accessions	O54781, Q8VCD9	Gene names	Srpk2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

JAM3_HUMAN
θ value	0.00175202 (rank : 927)	NC score	0.288997 (rank : 949)
Query Neighborhood Hits	1762	Target Neighborhood Hits	271	Shared Neighborhood Hits	221
SwissProt Accessions	Q9BX67, Q8WWL8, Q96FL1	Gene names	JAM3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

LRC21_HUMAN
θ value	0.00175202 (rank : 928)	NC score	0.172512 (rank : 1031)
Query Neighborhood Hits	1762	Target Neighborhood Hits	456	Shared Neighborhood Hits	220
SwissProt Accessions	Q9P2V4, Q9Y4N7	Gene names	LRRC21, PAL
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

NACAM_MOUSE
θ value	0.00175202 (rank : 929)	NC score	0.098560 (rank : 1126)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1866	Shared Neighborhood Hits	518
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

OGFR_HUMAN
θ value	0.00175202 (rank : 930)	NC score	0.077631 (rank : 1165)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1582	Shared Neighborhood Hits	437
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

RPKL1_MOUSE
θ value	0.00175202 (rank : 931)	NC score	0.699107 (rank : 628)
Query Neighborhood Hits	1762	Target Neighborhood Hits	704	Shared Neighborhood Hits	667
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

ASPP2_HUMAN
θ value	0.00228821 (rank : 932)	NC score	0.042157 (rank : 1361)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1156	Shared Neighborhood Hits	221
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

CEAM5_HUMAN
θ value	0.00228821 (rank : 933)	NC score	0.266400 (rank : 981)
Query Neighborhood Hits	1762	Target Neighborhood Hits	343	Shared Neighborhood Hits	245
SwissProt Accessions	P06731	Gene names	CEACAM5, CEA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 5 precursor (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD66e antigen).

IRPL1_HUMAN
θ value	0.00228821 (rank : 934)	NC score	0.155970 (rank : 1045)
Query Neighborhood Hits	1762	Target Neighborhood Hits	196	Shared Neighborhood Hits	151
SwissProt Accessions	Q9NZN1, Q9UJ53	Gene names	IL1RAPL1, OPHN4
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2).

IRPL1_MOUSE
θ value	0.00228821 (rank : 935)	NC score	0.160523 (rank : 1041)
Query Neighborhood Hits	1762	Target Neighborhood Hits	186	Shared Neighborhood Hits	147
SwissProt Accessions	P59823	Gene names	Il1rapl1
Domain Architecture	No domain graphic available
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1).

RIPK4_HUMAN
θ value	0.00228821 (rank : 936)	NC score	0.587405 (rank : 795)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1094	Shared Neighborhood Hits	795
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

SIGL5_MOUSE
θ value	0.00228821 (rank : 937)	NC score	0.220029 (rank : 1004)
Query Neighborhood Hits	1762	Target Neighborhood Hits	271	Shared Neighborhood Hits	218
SwissProt Accessions	Q920G3	Gene names	Siglec5, Siglecf
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Sialic acid-binding Ig-like lectin-F) (mSiglec-F).

TNI3K_MOUSE
θ value	0.00228821 (rank : 938)	NC score	0.655056 (rank : 731)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1079	Shared Neighborhood Hits	788
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

CNTRB_MOUSE
θ value	0.00298849 (rank : 939)	NC score	0.037083 (rank : 1400)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1029	Shared Neighborhood Hits	143
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

JAM3_MOUSE
θ value	0.00298849 (rank : 940)	NC score	0.287914 (rank : 953)
Query Neighborhood Hits	1762	Target Neighborhood Hits	286	Shared Neighborhood Hits	225
SwissProt Accessions	Q9D8B7, Q8BT59, Q9D1M9, Q9EPK4	Gene names	Jam3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

K1802_MOUSE
θ value	0.00298849 (rank : 941)	NC score	0.037424 (rank : 1396)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1596	Shared Neighborhood Hits	354
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

NRG2_MOUSE
θ value	0.00298849 (rank : 942)	NC score	0.248796 (rank : 993)
Query Neighborhood Hits	1762	Target Neighborhood Hits	392	Shared Neighborhood Hits	240
SwissProt Accessions	P56974	Gene names	Nrg2
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)].

PRRT3_HUMAN
θ value	0.00298849 (rank : 943)	NC score	0.074678 (rank : 1181)
Query Neighborhood Hits	1762	Target Neighborhood Hits	998	Shared Neighborhood Hits	342
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

SIG12_HUMAN
θ value	0.00298849 (rank : 944)	NC score	0.178903 (rank : 1021)
Query Neighborhood Hits	1762	Target Neighborhood Hits	245	Shared Neighborhood Hits	210
SwissProt Accessions	Q96PQ1, Q8IYH7	Gene names	SIGLEC12, SIGLECL1, SLG
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1).

SIGL6_HUMAN
θ value	0.00298849 (rank : 945)	NC score	0.174520 (rank : 1025)
Query Neighborhood Hits	1762	Target Neighborhood Hits	233	Shared Neighborhood Hits	192
SwissProt Accessions	O43699, O15388, O43700	Gene names	SIGLEC6, CD33L, CD33L1, OBBP1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 6 precursor (Siglec-6) (Obesity- binding protein 1) (OB-BP1) (CD33 antigen-like 1) (CDw327 antigen).

SPR1A_HUMAN
θ value	0.00298849 (rank : 946)	NC score	0.044005 (rank : 1348)
Query Neighborhood Hits	1762	Target Neighborhood Hits	136	Shared Neighborhood Hits	38
SwissProt Accessions	P35321, Q9UDG4	Gene names	SPRR1A
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein IA) (SPR-IA) (SPRK) (19 kDa pancornulin).

STK23_HUMAN
θ value	0.00298849 (rank : 947)	NC score	0.543037 (rank : 812)
Query Neighborhood Hits	1762	Target Neighborhood Hits	556	Shared Neighborhood Hits	551
SwissProt Accessions	Q9UPE1, Q13583, Q9UM62	Gene names	STK23, MSSK1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

STK23_MOUSE
θ value	0.00298849 (rank : 948)	NC score	0.543570 (rank : 810)
Query Neighborhood Hits	1762	Target Neighborhood Hits	572	Shared Neighborhood Hits	557
SwissProt Accessions	Q9Z0G2	Gene names	Stk23, Mssk1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

AATK_HUMAN
θ value	0.00390308 (rank : 949)	NC score	0.648128 (rank : 745)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1243	Shared Neighborhood Hits	905
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

CASC3_MOUSE
θ value	0.00390308 (rank : 950)	NC score	0.042675 (rank : 1357)
Query Neighborhood Hits	1762	Target Neighborhood Hits	333	Shared Neighborhood Hits	118
SwissProt Accessions	Q8K3W3, Q8K219, Q99NF0	Gene names	Casc3, Mln51
Domain Architecture	No domain graphic available
Description	Protein CASC3 (Cancer susceptibility candidate gene 3 protein homolog) (Metastatic lymph node protein 51 homolog) (Protein MLN 51 homolog) (Protein barentsz) (Btz).

CEAM1_HUMAN
θ value	0.00390308 (rank : 951)	NC score	0.236699 (rank : 996)
Query Neighborhood Hits	1762	Target Neighborhood Hits	348	Shared Neighborhood Hits	228
SwissProt Accessions	P13688, O60430, Q13858, Q15600, Q9UQV9	Gene names	CEACAM1, BGP, BGP1
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (CD66 antigen) (CD66a antigen).

IRPL2_HUMAN
θ value	0.00390308 (rank : 952)	NC score	0.163828 (rank : 1035)
Query Neighborhood Hits	1762	Target Neighborhood Hits	194	Shared Neighborhood Hits	140
SwissProt Accessions	Q9NP60, Q9NZN0	Gene names	IL1RAPL2, IL1R9
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (Interleukin-1 receptor 9) (IL-1R9) (IL-1 receptor accessory protein-like 2) (Three immunoglobulin domain- containing IL-1 receptor-related 1) (TIGIRR-1).

IRPL2_MOUSE
θ value	0.00390308 (rank : 953)	NC score	0.161543 (rank : 1040)
Query Neighborhood Hits	1762	Target Neighborhood Hits	195	Shared Neighborhood Hits	138
SwissProt Accessions	Q9ERS6, Q9ER66	Gene names	Il1rapl2
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (TIGIRR-1).

KIRR1_HUMAN
θ value	0.00390308 (rank : 954)	NC score	0.288144 (rank : 950)
Query Neighborhood Hits	1762	Target Neighborhood Hits	401	Shared Neighborhood Hits	236
SwissProt Accessions	Q96J84, Q5XKC6, Q7Z696, Q7Z7N8, Q8TB15, Q9H9N1, Q9NVA5	Gene names	KIRREL, NEPH1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

LU_HUMAN
θ value	0.00390308 (rank : 955)	NC score	0.312120 (rank : 933)
Query Neighborhood Hits	1762	Target Neighborhood Hits	283	Shared Neighborhood Hits	233
SwissProt Accessions	P50895, Q86VC7	Gene names	BCAM, LU, MSK19
Domain Architecture
Description	Lutheran blood group glycoprotein precursor (B-CAM cell surface glycoprotein) (Auberger B antigen) (F8/G253 antigen) (CD239 antigen).

MDC1_MOUSE
θ value	0.00390308 (rank : 956)	NC score	0.076603 (rank : 1173)
Query Neighborhood Hits	1762	Target Neighborhood Hits	998	Shared Neighborhood Hits	303
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MUCDL_HUMAN
θ value	0.00390308 (rank : 957)	NC score	0.039084 (rank : 1383)
Query Neighborhood Hits	1762	Target Neighborhood Hits	777	Shared Neighborhood Hits	248
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

VSIG2_MOUSE
θ value	0.00390308 (rank : 958)	NC score	0.262042 (rank : 985)
Query Neighborhood Hits	1762	Target Neighborhood Hits	316	Shared Neighborhood Hits	209
SwissProt Accessions	Q9Z109, Q9CVA4, Q9D0T4	Gene names	Vsig2, Ctm, Ctxl
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

ICAM5_HUMAN
θ value	0.00509761 (rank : 959)	NC score	0.288125 (rank : 951)
Query Neighborhood Hits	1762	Target Neighborhood Hits	276	Shared Neighborhood Hits	226
SwissProt Accessions	Q9UMF0, Q9Y6F3	Gene names	ICAM5, TLCN, TLN
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

NCOA6_HUMAN
θ value	0.00509761 (rank : 960)	NC score	0.067867 (rank : 1215)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1202	Shared Neighborhood Hits	376
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

SAPS1_HUMAN
θ value	0.00509761 (rank : 961)	NC score	0.047577 (rank : 1335)
Query Neighborhood Hits	1762	Target Neighborhood Hits	704	Shared Neighborhood Hits	239
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

SIGL5_HUMAN
θ value	0.00509761 (rank : 962)	NC score	0.190368 (rank : 1013)
Query Neighborhood Hits	1762	Target Neighborhood Hits	246	Shared Neighborhood Hits	187
SwissProt Accessions	O15389	Gene names	SIGLEC5, CD33L2, OBBP2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Obesity- binding protein 2) (OB-binding protein 2) (OB-BP2) (CD33 antigen-like 2) (CD170 antigen).

SRRM2_HUMAN
θ value	0.00509761 (rank : 963)	NC score	0.101499 (rank : 1121)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1296	Shared Neighborhood Hits	395
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

CDC7_HUMAN
θ value	0.00665767 (rank : 964)	NC score	0.686091 (rank : 657)
Query Neighborhood Hits	1762	Target Neighborhood Hits	652	Shared Neighborhood Hits	632
SwissProt Accessions	O00311, O00558	Gene names	CDC7, CDC7L1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (HsCdc7) (huCdc7).

CO039_MOUSE
θ value	0.00665767 (rank : 965)	NC score	0.051534 (rank : 1306)
Query Neighborhood Hits	1762	Target Neighborhood Hits	445	Shared Neighborhood Hits	178
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

CSTF2_HUMAN
θ value	0.00665767 (rank : 966)	NC score	0.005875 (rank : 1748)
Query Neighborhood Hits	1762	Target Neighborhood Hits	296	Shared Neighborhood Hits	49
SwissProt Accessions	P33240, Q5H951, Q6LA74, Q8N502	Gene names	CSTF2
Domain Architecture
Description	Cleavage stimulation factor 64 kDa subunit (CSTF 64 kDa subunit) (CF-1 64 kDa subunit) (CstF-64).

CSTFT_MOUSE
θ value	0.00665767 (rank : 967)	NC score	0.010918 (rank : 1671)
Query Neighborhood Hits	1762	Target Neighborhood Hits	356	Shared Neighborhood Hits	74
SwissProt Accessions	Q8C7E9, Q6A016, Q8BHH7, Q8C3W7, Q8R2Y1, Q9EPU3	Gene names	Cstf2t, Kiaa0689
Domain Architecture	No domain graphic available
Description	Cleavage stimulation factor 64 kDa subunit, tau variant (CSTF 64 kDa subunit, tau variant) (CF-1 64 kDa subunit, tau variant) (TauCstF-64).

IBP7_HUMAN
θ value	0.00665767 (rank : 968)	NC score	0.246840 (rank : 994)
Query Neighborhood Hits	1762	Target Neighborhood Hits	220	Shared Neighborhood Hits	165
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

IBP7_MOUSE
θ value	0.00665767 (rank : 969)	NC score	0.236443 (rank : 997)
Query Neighborhood Hits	1762	Target Neighborhood Hits	230	Shared Neighborhood Hits	161
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

IGS4B_HUMAN
θ value	0.00665767 (rank : 970)	NC score	0.264548 (rank : 982)
Query Neighborhood Hits	1762	Target Neighborhood Hits	305	Shared Neighborhood Hits	221
SwissProt Accessions	Q8N126, Q9NVJ5, Q9UJP1	Gene names	IGSF4B, NECL1, SYNCAM3, TSLL1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3) (Brain immunoglobulin receptor).

JAM1_MOUSE
θ value	0.00665767 (rank : 971)	NC score	0.278730 (rank : 965)
Query Neighborhood Hits	1762	Target Neighborhood Hits	287	Shared Neighborhood Hits	219
SwissProt Accessions	O88792	Gene names	F11r, Jam1, Jcam, Jcam1
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (CD321 antigen).

LPP_HUMAN
θ value	0.00665767 (rank : 972)	NC score	0.029288 (rank : 1458)
Query Neighborhood Hits	1762	Target Neighborhood Hits	775	Shared Neighborhood Hits	221
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

NRG2_HUMAN
θ value	0.00665767 (rank : 973)	NC score	0.256593 (rank : 989)
Query Neighborhood Hits	1762	Target Neighborhood Hits	419	Shared Neighborhood Hits	257
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

PCLO_MOUSE
θ value	0.00665767 (rank : 974)	NC score	0.080921 (rank : 1155)
Query Neighborhood Hits	1762	Target Neighborhood Hits	2275	Shared Neighborhood Hits	553
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

SRPK1_HUMAN
θ value	0.00665767 (rank : 975)	NC score	0.544175 (rank : 809)
Query Neighborhood Hits	1762	Target Neighborhood Hits	706	Shared Neighborhood Hits	584
SwissProt Accessions	Q96SB4, Q12890, Q5R364, Q5R365, Q8IY12	Gene names	SRPK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

SRPK1_MOUSE
θ value	0.00665767 (rank : 976)	NC score	0.545983 (rank : 807)
Query Neighborhood Hits	1762	Target Neighborhood Hits	639	Shared Neighborhood Hits	567
SwissProt Accessions	O70551, O70193, Q99JT3	Gene names	Srpk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

UFO_HUMAN
θ value	0.00665767 (rank : 977)	NC score	0.677674 (rank : 676)
Query Neighborhood Hits	1762	Target Neighborhood Hits	981	Shared Neighborhood Hits	895
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

UFO_MOUSE
θ value	0.00665767 (rank : 978)	NC score	0.684590 (rank : 659)
Query Neighborhood Hits	1762	Target Neighborhood Hits	988	Shared Neighborhood Hits	893
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

EPHB6_HUMAN
θ value	0.00869519 (rank : 979)	NC score	0.555556 (rank : 805)
Query Neighborhood Hits	1762	Target Neighborhood Hits	912	Shared Neighborhood Hits	753
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

FA61A_MOUSE
θ value	0.00869519 (rank : 980)	NC score	0.023751 (rank : 1508)
Query Neighborhood Hits	1762	Target Neighborhood Hits	81	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K2F8, Q9CTG8	Gene names	Fam61a
Domain Architecture	No domain graphic available
Description	Protein FAM61A.

GUC2G_MOUSE
θ value	0.00869519 (rank : 981)	NC score	0.445258 (rank : 827)
Query Neighborhood Hits	1762	Target Neighborhood Hits	644	Shared Neighborhood Hits	571
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

IASPP_MOUSE
θ value	0.00869519 (rank : 982)	NC score	0.058290 (rank : 1264)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1024	Shared Neighborhood Hits	300
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

JAM2_MOUSE
θ value	0.00869519 (rank : 983)	NC score	0.272774 (rank : 977)
Query Neighborhood Hits	1762	Target Neighborhood Hits	292	Shared Neighborhood Hits	230
SwissProt Accessions	Q9JI59, Q8C5K9, Q8CE95	Gene names	Jam2, Vejam
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

NGL1_HUMAN
θ value	0.00869519 (rank : 984)	NC score	0.120615 (rank : 1085)
Query Neighborhood Hits	1762	Target Neighborhood Hits	511	Shared Neighborhood Hits	220
SwissProt Accessions	Q9HCJ2, Q7L0N3	Gene names	LRRC4C, KIAA1580, NGL1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

NPTN_HUMAN
θ value	0.00869519 (rank : 985)	NC score	0.296349 (rank : 944)
Query Neighborhood Hits	1762	Target Neighborhood Hits	212	Shared Neighborhood Hits	193
SwissProt Accessions	Q9Y639, Q59EJ9, Q6NVX7, Q9Y640	Gene names	NPTN, SDFR1, SDR1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

RGS3_HUMAN
θ value	0.00869519 (rank : 986)	NC score	0.059704 (rank : 1253)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1375	Shared Neighborhood Hits	349
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

SEPT9_HUMAN
θ value	0.00869519 (rank : 987)	NC score	0.029969 (rank : 1450)
Query Neighborhood Hits	1762	Target Neighborhood Hits	706	Shared Neighborhood Hits	218
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

SRRM1_MOUSE
θ value	0.00869519 (rank : 988)	NC score	0.114280 (rank : 1100)
Query Neighborhood Hits	1762	Target Neighborhood Hits	966	Shared Neighborhood Hits	351
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

SVIL_HUMAN
θ value	0.00869519 (rank : 989)	NC score	0.028009 (rank : 1468)
Query Neighborhood Hits	1762	Target Neighborhood Hits	232	Shared Neighborhood Hits	60
SwissProt Accessions	O95425, O60611, O60612, Q5VZK5, Q5VZK6, Q9H1R7	Gene names	SVIL
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

ACVR1_MOUSE
θ value	0.0113563 (rank : 990)	NC score	0.628336 (rank : 763)
Query Neighborhood Hits	1762	Target Neighborhood Hits	768	Shared Neighborhood Hits	747
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

ILRL1_HUMAN
θ value	0.0113563 (rank : 991)	NC score	0.123251 (rank : 1082)
Query Neighborhood Hits	1762	Target Neighborhood Hits	167	Shared Neighborhood Hits	121
SwissProt Accessions	Q01638, Q53TU7, Q8NEJ3, Q9ULV7, Q9UQ44	Gene names	IL1RL1, DER4, ST2, T1
Domain Architecture
Description	Interleukin-1 receptor-like 1 precursor (ST2 protein).

JADE2_MOUSE
θ value	0.0113563 (rank : 992)	NC score	0.023140 (rank : 1516)
Query Neighborhood Hits	1762	Target Neighborhood Hits	560	Shared Neighborhood Hits	180
SwissProt Accessions	Q6ZQF7, Q3UHD5, Q6IE83	Gene names	Phf15, Jade2, Kiaa0239
Domain Architecture	No domain graphic available
Description	Protein Jade-2 (PHD finger protein 15).

JPH2_HUMAN
θ value	0.0113563 (rank : 993)	NC score	0.041498 (rank : 1366)
Query Neighborhood Hits	1762	Target Neighborhood Hits	639	Shared Neighborhood Hits	225
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

NGL1_MOUSE
θ value	0.0113563 (rank : 994)	NC score	0.120572 (rank : 1086)
Query Neighborhood Hits	1762	Target Neighborhood Hits	512	Shared Neighborhood Hits	220
SwissProt Accessions	Q8C031, Q8BGH8	Gene names	Lrrc4c, Ngl1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

TGFR2_HUMAN
θ value	0.0113563 (rank : 995)	NC score	0.637411 (rank : 753)
Query Neighborhood Hits	1762	Target Neighborhood Hits	748	Shared Neighborhood Hits	728
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TGFR2_MOUSE
θ value	0.0113563 (rank : 996)	NC score	0.637518 (rank : 752)
Query Neighborhood Hits	1762	Target Neighborhood Hits	748	Shared Neighborhood Hits	729
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

VRK2_MOUSE
θ value	0.0113563 (rank : 997)	NC score	0.488019 (rank : 819)
Query Neighborhood Hits	1762	Target Neighborhood Hits	586	Shared Neighborhood Hits	573
SwissProt Accessions	Q8BN21, Q5F1Z5, Q5SP88, Q8BPU8, Q8CJ46, Q91WS1, Q9CZF9	Gene names	Vrk2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

ACVR1_HUMAN
θ value	0.0148317 (rank : 998)	NC score	0.622164 (rank : 768)
Query Neighborhood Hits	1762	Target Neighborhood Hits	760	Shared Neighborhood Hits	741
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

AL2S2_HUMAN
θ value	0.0148317 (rank : 999)	NC score	0.729780 (rank : 584)
Query Neighborhood Hits	1762	Target Neighborhood Hits	727	Shared Neighborhood Hits	706
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

CILP1_HUMAN
θ value	0.0148317 (rank : 1000)	NC score	0.149897 (rank : 1055)
Query Neighborhood Hits	1762	Target Neighborhood Hits	266	Shared Neighborhood Hits	171
SwissProt Accessions	O75339, Q6UW99, Q8IYI5	Gene names	CILP
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) (Cartilage intermediate-layer protein) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

FYB_HUMAN
θ value	0.0148317 (rank : 1001)	NC score	0.043319 (rank : 1352)
Query Neighborhood Hits	1762	Target Neighborhood Hits	379	Shared Neighborhood Hits	124
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

KIRR1_MOUSE
θ value	0.0148317 (rank : 1002)	NC score	0.284283 (rank : 958)
Query Neighborhood Hits	1762	Target Neighborhood Hits	403	Shared Neighborhood Hits	235
SwissProt Accessions	Q80W68, Q8CIJ4, Q8CJ59, Q923L4	Gene names	Kirrel1, Kirrel, Neph1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

LRRN5_HUMAN
θ value	0.0148317 (rank : 1003)	NC score	0.144495 (rank : 1063)
Query Neighborhood Hits	1762	Target Neighborhood Hits	493	Shared Neighborhood Hits	236
SwissProt Accessions	O75325, Q5T0Y0, Q6UXM0, Q8N182	Gene names	LRRN5, GAC1, LRRN2
Domain Architecture
Description	Leucine-rich repeats neuronal protein 5 precursor (Glioma amplified on chromosome 1 protein).

ZN318_HUMAN
θ value	0.0148317 (rank : 1004)	NC score	0.027250 (rank : 1475)
Query Neighborhood Hits	1762	Target Neighborhood Hits	497	Shared Neighborhood Hits	97
SwissProt Accessions	Q5VUA4, O94796, Q4G0E4, Q8NEM6, Q9UNU8, Q9Y2W9	Gene names	ZNF318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Endocrine regulatory protein).

CEL_HUMAN
θ value	0.0193708 (rank : 1005)	NC score	0.026780 (rank : 1481)
Query Neighborhood Hits	1762	Target Neighborhood Hits	896	Shared Neighborhood Hits	245
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

GUC2D_HUMAN
θ value	0.0193708 (rank : 1006)	NC score	0.466170 (rank : 825)
Query Neighborhood Hits	1762	Target Neighborhood Hits	715	Shared Neighborhood Hits	653
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

LRRN3_HUMAN
θ value	0.0193708 (rank : 1007)	NC score	0.153228 (rank : 1047)
Query Neighborhood Hits	1762	Target Neighborhood Hits	461	Shared Neighborhood Hits	222
SwissProt Accessions	Q9H3W5, O43377, Q6I9V8, Q8IYQ6	Gene names	LRRN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

MLL3_MOUSE
θ value	0.0193708 (rank : 1008)	NC score	0.036737 (rank : 1404)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1399	Shared Neighborhood Hits	314
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

SOX13_MOUSE
θ value	0.0193708 (rank : 1009)	NC score	0.018934 (rank : 1561)
Query Neighborhood Hits	1762	Target Neighborhood Hits	495	Shared Neighborhood Hits	140
SwissProt Accessions	Q04891, Q922L3	Gene names	Sox13, Sox-13
Domain Architecture
Description	SOX-13 protein.

SPR1B_HUMAN
θ value	0.0193708 (rank : 1010)	NC score	0.040016 (rank : 1376)
Query Neighborhood Hits	1762	Target Neighborhood Hits	102	Shared Neighborhood Hits	25
SwissProt Accessions	P22528, P22529, P22530, Q5T524	Gene names	SPRR1B
Domain Architecture	No domain graphic available
Description	Cornifin B (Small proline-rich protein IB) (SPR-IB) (14.9 kDa pancornulin).

XRCC1_HUMAN
θ value	0.0193708 (rank : 1011)	NC score	0.032454 (rank : 1430)
Query Neighborhood Hits	1762	Target Neighborhood Hits	131	Shared Neighborhood Hits	56
SwissProt Accessions	P18887, Q9HCB1	Gene names	XRCC1
Domain Architecture
Description	DNA-repair protein XRCC1 (X-ray repair cross-complementing protein 1).

ZN688_HUMAN
θ value	0.0193708 (rank : 1012)	NC score	-0.024560 (rank : 1929)
Query Neighborhood Hits	1762	Target Neighborhood Hits	873	Shared Neighborhood Hits	89
SwissProt Accessions	Q8WV14, O75701, Q8IW91, Q96MN0	Gene names	ZNF688
Domain Architecture	No domain graphic available
Description	Zinc finger protein 688.

CILP2_HUMAN
θ value	0.0252991 (rank : 1013)	NC score	0.183570 (rank : 1019)
Query Neighborhood Hits	1762	Target Neighborhood Hits	307	Shared Neighborhood Hits	190
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

GRIN1_HUMAN
θ value	0.0252991 (rank : 1014)	NC score	0.055942 (rank : 1280)
Query Neighborhood Hits	1762	Target Neighborhood Hits	681	Shared Neighborhood Hits	234
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

HCN2_HUMAN
θ value	0.0252991 (rank : 1015)	NC score	0.024922 (rank : 1498)
Query Neighborhood Hits	1762	Target Neighborhood Hits	369	Shared Neighborhood Hits	161
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

IWS1_MOUSE
θ value	0.0252991 (rank : 1016)	NC score	0.038234 (rank : 1389)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1258	Shared Neighborhood Hits	236
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

K2002_HUMAN
θ value	0.0252991 (rank : 1017)	NC score	0.331014 (rank : 921)
Query Neighborhood Hits	1762	Target Neighborhood Hits	274	Shared Neighborhood Hits	262
SwissProt Accessions	Q9H792, Q6ZS78, Q8NCM3	Gene names	KIAA2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

PHF8_HUMAN
θ value	0.0252991 (rank : 1018)	NC score	0.005662 (rank : 1754)
Query Neighborhood Hits	1762	Target Neighborhood Hits	105	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UPP1, Q5H9U5, Q5VUJ4, Q7Z6D4, Q9HAH2	Gene names	PHF8, KIAA1111, ZNF422
Domain Architecture	No domain graphic available
Description	PHD finger protein 8.

SIGL7_HUMAN
θ value	0.0252991 (rank : 1019)	NC score	0.139533 (rank : 1066)
Query Neighborhood Hits	1762	Target Neighborhood Hits	180	Shared Neighborhood Hits	151
SwissProt Accessions	Q9Y286, Q9NZQ1, Q9UJ86, Q9UJ87, Q9Y502	Gene names	SIGLEC7, AIRM1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 7 precursor (Siglec-7) (QA79 membrane protein) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (p75) (D-siglec) (CDw328 antigen).

TARA_HUMAN
θ value	0.0252991 (rank : 1020)	NC score	0.059462 (rank : 1256)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1626	Shared Neighborhood Hits	368
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

USH2A_HUMAN
θ value	0.0252991 (rank : 1021)	NC score	0.130212 (rank : 1074)
Query Neighborhood Hits	1762	Target Neighborhood Hits	600	Shared Neighborhood Hits	161
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

USH2A_MOUSE
θ value	0.0252991 (rank : 1022)	NC score	0.124194 (rank : 1079)
Query Neighborhood Hits	1762	Target Neighborhood Hits	626	Shared Neighborhood Hits	170
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

ZC3H6_MOUSE
θ value	0.0252991 (rank : 1023)	NC score	0.012333 (rank : 1650)
Query Neighborhood Hits	1762	Target Neighborhood Hits	239	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BYK8, Q80UK3, Q8C1H1, Q9D604	Gene names	Zc3h6, Zc3hdc6
Domain Architecture
Description	Zinc finger CCCH domain-containing protein 6.

BCL6_HUMAN
θ value	0.0330416 (rank : 1024)	NC score	-0.025759 (rank : 1932)
Query Neighborhood Hits	1762	Target Neighborhood Hits	922	Shared Neighborhood Hits	83
SwissProt Accessions	P41182	Gene names	BCL6, BCL5, LAZ3, ZBTB27, ZNF51
Domain Architecture
Description	B-cell lymphoma 6 protein (BCL-6) (Zinc finger protein 51) (LAZ-3 protein) (BCL-5) (Zinc finger and BTB domain-containing protein 27).

CAC1A_HUMAN
θ value	0.0330416 (rank : 1025)	NC score	0.009345 (rank : 1691)
Query Neighborhood Hits	1762	Target Neighborhood Hits	387	Shared Neighborhood Hits	124
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

EPHB6_MOUSE
θ value	0.0330416 (rank : 1026)	NC score	0.568353 (rank : 801)
Query Neighborhood Hits	1762	Target Neighborhood Hits	906	Shared Neighborhood Hits	775
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

FA47A_HUMAN
θ value	0.0330416 (rank : 1027)	NC score	0.055245 (rank : 1284)
Query Neighborhood Hits	1762	Target Neighborhood Hits	451	Shared Neighborhood Hits	165
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

GNAS1_MOUSE
θ value	0.0330416 (rank : 1028)	NC score	0.020112 (rank : 1551)
Query Neighborhood Hits	1762	Target Neighborhood Hits	651	Shared Neighborhood Hits	198
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

HSF1_MOUSE
θ value	0.0330416 (rank : 1029)	NC score	0.019945 (rank : 1552)
Query Neighborhood Hits	1762	Target Neighborhood Hits	267	Shared Neighborhood Hits	88
SwissProt Accessions	P38532, O70462	Gene names	Hsf1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

IL1R2_MOUSE
θ value	0.0330416 (rank : 1030)	NC score	0.156935 (rank : 1044)
Query Neighborhood Hits	1762	Target Neighborhood Hits	125	Shared Neighborhood Hits	97
SwissProt Accessions	P27931	Gene names	Il1r2, Il-1r2, Il1rb
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen).

K2002_MOUSE
θ value	0.0330416 (rank : 1031)	NC score	0.273674 (rank : 974)
Query Neighborhood Hits	1762	Target Neighborhood Hits	267	Shared Neighborhood Hits	233
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

LRRN3_MOUSE
θ value	0.0330416 (rank : 1032)	NC score	0.144711 (rank : 1061)
Query Neighborhood Hits	1762	Target Neighborhood Hits	455	Shared Neighborhood Hits	218
SwissProt Accessions	Q8CBC6, P97860	Gene names	Lrrn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

MFA3L_HUMAN
θ value	0.0330416 (rank : 1033)	NC score	0.266725 (rank : 979)
Query Neighborhood Hits	1762	Target Neighborhood Hits	230	Shared Neighborhood Hits	209
SwissProt Accessions	O75121, Q6TNA8, Q9BVE1, Q9BXK0	Gene names	MFAP3L, KIAA0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor (Protein kinase NYD-SP9).

PHLB1_HUMAN
θ value	0.0330416 (rank : 1034)	NC score	0.035321 (rank : 1413)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1038	Shared Neighborhood Hits	209
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

SMOO_HUMAN
θ value	0.0330416 (rank : 1035)	NC score	0.035547 (rank : 1411)
Query Neighborhood Hits	1762	Target Neighborhood Hits	391	Shared Neighborhood Hits	159
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

SVIL_MOUSE
θ value	0.0330416 (rank : 1036)	NC score	0.030432 (rank : 1448)
Query Neighborhood Hits	1762	Target Neighborhood Hits	439	Shared Neighborhood Hits	103
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

TITF1_MOUSE
θ value	0.0330416 (rank : 1037)	NC score	-0.007875 (rank : 1896)
Query Neighborhood Hits	1762	Target Neighborhood Hits	335	Shared Neighborhood Hits	15
SwissProt Accessions	P50220	Gene names	Titf1, Nkx-2.1, Nkx2-1, Ttf1
Domain Architecture	No domain graphic available
Description	Thyroid transcription factor 1 (Thyroid nuclear factor 1) (TTF-1) (Homeobox protein Nkx-2.1).

TMIGD_HUMAN
θ value	0.0330416 (rank : 1038)	NC score	0.313136 (rank : 931)
Query Neighborhood Hits	1762	Target Neighborhood Hits	240	Shared Neighborhood Hits	210
SwissProt Accessions	Q6UXZ0, Q6ZMC6	Gene names	TMIGD
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

BT1A1_MOUSE
θ value	0.0431538 (rank : 1039)	NC score	0.039440 (rank : 1381)
Query Neighborhood Hits	1762	Target Neighborhood Hits	252	Shared Neighborhood Hits	100
SwissProt Accessions	Q62556, P97392, Q8K2H7, Q921K7	Gene names	Btn1a1, Btn
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

CD248_HUMAN
θ value	0.0431538 (rank : 1040)	NC score	0.023669 (rank : 1510)
Query Neighborhood Hits	1762	Target Neighborhood Hits	679	Shared Neighborhood Hits	167
SwissProt Accessions	Q9HCU0, Q3SX55, Q96KB6	Gene names	CD248, CD164L1, TEM1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

CILP1_MOUSE
θ value	0.0431538 (rank : 1041)	NC score	0.158120 (rank : 1042)
Query Neighborhood Hits	1762	Target Neighborhood Hits	282	Shared Neighborhood Hits	188
SwissProt Accessions	Q66K08, Q7TSS0, Q7TSS1, Q8BV01	Gene names	Cilp
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

GPA33_MOUSE
θ value	0.0431538 (rank : 1042)	NC score	0.218458 (rank : 1005)
Query Neighborhood Hits	1762	Target Neighborhood Hits	294	Shared Neighborhood Hits	177
SwissProt Accessions	Q9JKA5, Q922D5	Gene names	Gpa33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33) (mA33).

GUC2E_MOUSE
θ value	0.0431538 (rank : 1043)	NC score	0.443798 (rank : 828)
Query Neighborhood Hits	1762	Target Neighborhood Hits	692	Shared Neighborhood Hits	626
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

LAG3_MOUSE
θ value	0.0431538 (rank : 1044)	NC score	0.107322 (rank : 1107)
Query Neighborhood Hits	1762	Target Neighborhood Hits	117	Shared Neighborhood Hits	83
SwissProt Accessions	Q61790, Q0VBL2	Gene names	Lag3
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (CD223 antigen).

MBB1A_HUMAN
θ value	0.0431538 (rank : 1045)	NC score	0.048864 (rank : 1326)
Query Neighborhood Hits	1762	Target Neighborhood Hits	665	Shared Neighborhood Hits	202
SwissProt Accessions	Q9BQG0, Q86VM3, Q9BW49, Q9P0V5, Q9UF99	Gene names	MYBBP1A, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A.

PELP1_HUMAN
θ value	0.0431538 (rank : 1046)	NC score	0.048241 (rank : 1329)
Query Neighborhood Hits	1762	Target Neighborhood Hits	596	Shared Neighborhood Hits	171
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

PELP1_MOUSE
θ value	0.0431538 (rank : 1047)	NC score	0.050603 (rank : 1314)
Query Neighborhood Hits	1762	Target Neighborhood Hits	709	Shared Neighborhood Hits	213
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

PSG3_HUMAN
θ value	0.0431538 (rank : 1048)	NC score	0.173762 (rank : 1027)
Query Neighborhood Hits	1762	Target Neighborhood Hits	242	Shared Neighborhood Hits	192
SwissProt Accessions	Q16557, Q08265, Q9BRW2, Q9UPL4, Q9UQ77	Gene names	PSG3
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 3 precursor (PSBG-3) (Carcinoembryonic antigen SG5).

RIMB1_HUMAN
θ value	0.0431538 (rank : 1049)	NC score	0.049339 (rank : 1324)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1479	Shared Neighborhood Hits	301
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

UBP43_HUMAN
θ value	0.0431538 (rank : 1050)	NC score	0.002597 (rank : 1807)
Query Neighborhood Hits	1762	Target Neighborhood Hits	144	Shared Neighborhood Hits	32
SwissProt Accessions	Q70EL4, Q8N2C5, Q96DQ6	Gene names	USP43
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.1.2.15) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) (Deubiquitinating enzyme 43).

BMR1A_HUMAN
θ value	0.0563607 (rank : 1051)	NC score	0.615333 (rank : 774)
Query Neighborhood Hits	1762	Target Neighborhood Hits	759	Shared Neighborhood Hits	735
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

BMR1A_MOUSE
θ value	0.0563607 (rank : 1052)	NC score	0.614377 (rank : 775)
Query Neighborhood Hits	1762	Target Neighborhood Hits	758	Shared Neighborhood Hits	735
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

BUB1_HUMAN
θ value	0.0563607 (rank : 1053)	NC score	0.405996 (rank : 839)
Query Neighborhood Hits	1762	Target Neighborhood Hits	543	Shared Neighborhood Hits	417
SwissProt Accessions	O43683, O43430, O43643, O60626	Gene names	BUB1, BUB1L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (hBUB1) (BUB1A).

CBP_HUMAN
θ value	0.0563607 (rank : 1054)	NC score	0.049630 (rank : 1323)
Query Neighborhood Hits	1762	Target Neighborhood Hits	941	Shared Neighborhood Hits	301
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CBP_MOUSE
θ value	0.0563607 (rank : 1055)	NC score	0.048448 (rank : 1328)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1051	Shared Neighborhood Hits	320
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CLCN1_HUMAN
θ value	0.0563607 (rank : 1056)	NC score	0.005393 (rank : 1761)
Query Neighborhood Hits	1762	Target Neighborhood Hits	89	Shared Neighborhood Hits	30
SwissProt Accessions	P35523	Gene names	CLCN1, CLC1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

DMRTD_HUMAN
θ value	0.0563607 (rank : 1057)	NC score	0.020277 (rank : 1546)
Query Neighborhood Hits	1762	Target Neighborhood Hits	216	Shared Neighborhood Hits	85
SwissProt Accessions	Q8IXT2, Q8N6Q2, Q96M39, Q96SD4	Gene names	DMRTC2
Domain Architecture	No domain graphic available
Description	Doublesex- and mab-3-related transcription factor C2.

GNAS1_HUMAN
θ value	0.0563607 (rank : 1058)	NC score	0.013074 (rank : 1634)
Query Neighborhood Hits	1762	Target Neighborhood Hits	278	Shared Neighborhood Hits	98
SwissProt Accessions	Q5JWF2, O75684, O75685, Q5JW67, Q5JWF1, Q9NY42	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

ILRL2_MOUSE
θ value	0.0563607 (rank : 1059)	NC score	0.129051 (rank : 1075)
Query Neighborhood Hits	1762	Target Neighborhood Hits	158	Shared Neighborhood Hits	137
SwissProt Accessions	Q9ERS7	Gene names	Il1rl2
Domain Architecture
Description	Interleukin-1 receptor-like 2 precursor (IL-1Rrp2).

PCLO_HUMAN
θ value	0.0563607 (rank : 1060)	NC score	0.076757 (rank : 1172)
Query Neighborhood Hits	1762	Target Neighborhood Hits	2046	Shared Neighborhood Hits	493
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

RTP3_MOUSE
θ value	0.0563607 (rank : 1061)	NC score	0.042451 (rank : 1359)
Query Neighborhood Hits	1762	Target Neighborhood Hits	374	Shared Neighborhood Hits	133
SwissProt Accessions	Q5QGU6, Q8VDC2	Gene names	Rtp3, Tmem7
Domain Architecture	No domain graphic available
Description	Receptor-transporting protein 3 (Transmembrane protein 7).

SPRE3_HUMAN
θ value	0.0563607 (rank : 1062)	NC score	0.014102 (rank : 1622)
Query Neighborhood Hits	1762	Target Neighborhood Hits	65	Shared Neighborhood Hits	31
SwissProt Accessions	Q2MJR0	Gene names	SPRED3
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 3 (Spred-3).

ARMX2_HUMAN
θ value	0.0736092 (rank : 1063)	NC score	0.026071 (rank : 1488)
Query Neighborhood Hits	1762	Target Neighborhood Hits	134	Shared Neighborhood Hits	59
SwissProt Accessions	Q7L311, O60267, Q5H9D9	Gene names	ARMCX2, ALEX2, KIAA0512
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing X-linked protein 2 (Protein ALEX2) (ARM protein lost in epithelial cancers on chromosome X 2).

NPTN_MOUSE
θ value	0.0736092 (rank : 1064)	NC score	0.295327 (rank : 946)
Query Neighborhood Hits	1762	Target Neighborhood Hits	216	Shared Neighborhood Hits	195
SwissProt Accessions	P97300, Q3U519, Q8C637, Q8C6H8	Gene names	Nptn, Sdfr1, Sdr1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

PDLI7_HUMAN
θ value	0.0736092 (rank : 1065)	NC score	0.012356 (rank : 1649)
Query Neighborhood Hits	1762	Target Neighborhood Hits	547	Shared Neighborhood Hits	136
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

SAHH3_HUMAN
θ value	0.0736092 (rank : 1066)	NC score	0.008832 (rank : 1701)
Query Neighborhood Hits	1762	Target Neighborhood Hits	23	Shared Neighborhood Hits	8
SwissProt Accessions	Q96HN2, O94917	Gene names	KIAA0828
Domain Architecture
Description	Putative adenosylhomocysteinase 3 (EC 3.3.1.1) (S-adenosyl-L- homocysteine hydrolase 3) (AdoHcyase 3).

SELPL_MOUSE
θ value	0.0736092 (rank : 1067)	NC score	0.057215 (rank : 1274)
Query Neighborhood Hits	1762	Target Neighborhood Hits	588	Shared Neighborhood Hits	208
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

SREC2_HUMAN
θ value	0.0736092 (rank : 1068)	NC score	0.023935 (rank : 1506)
Query Neighborhood Hits	1762	Target Neighborhood Hits	645	Shared Neighborhood Hits	161
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

TP53B_MOUSE
θ value	0.0736092 (rank : 1069)	NC score	0.042794 (rank : 1356)
Query Neighborhood Hits	1762	Target Neighborhood Hits	644	Shared Neighborhood Hits	169
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

XKR7_MOUSE
θ value	0.0736092 (rank : 1070)	NC score	0.008539 (rank : 1706)
Query Neighborhood Hits	1762	Target Neighborhood Hits	146	Shared Neighborhood Hits	42
SwissProt Accessions	Q5GH64	Gene names	Xkr7, Xrg7
Domain Architecture	No domain graphic available
Description	XK-related protein 7.

A1BG_HUMAN
θ value	0.0961366 (rank : 1071)	NC score	0.056099 (rank : 1278)
Query Neighborhood Hits	1762	Target Neighborhood Hits	94	Shared Neighborhood Hits	42
SwissProt Accessions	P04217, Q8IYJ6, Q96P39	Gene names	A1BG
Domain Architecture
Description	Alpha-1B-glycoprotein precursor (Alpha-1-B glycoprotein).

AL2S2_MOUSE
θ value	0.0961366 (rank : 1072)	NC score	0.716703 (rank : 602)
Query Neighborhood Hits	1762	Target Neighborhood Hits	709	Shared Neighborhood Hits	687
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

ELF4_MOUSE
θ value	0.0961366 (rank : 1073)	NC score	0.010225 (rank : 1683)
Query Neighborhood Hits	1762	Target Neighborhood Hits	191	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Z2U4	Gene names	Elf4, Mef
Domain Architecture	No domain graphic available
Description	ETS-related transcription factor Elf-4 (E74-like factor 4) (Myeloid Elf-1-like factor).

FOG1_HUMAN
θ value	0.0961366 (rank : 1074)	NC score	-0.007035 (rank : 1892)
Query Neighborhood Hits	1762	Target Neighborhood Hits	981	Shared Neighborhood Hits	175
SwissProt Accessions	Q8IX07	Gene names	ZFPM1, FOG1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

JIP1_HUMAN
θ value	0.0961366 (rank : 1075)	NC score	0.025041 (rank : 1496)
Query Neighborhood Hits	1762	Target Neighborhood Hits	271	Shared Neighborhood Hits	83
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

MAGD4_HUMAN
θ value	0.0961366 (rank : 1076)	NC score	0.012520 (rank : 1645)
Query Neighborhood Hits	1762	Target Neighborhood Hits	338	Shared Neighborhood Hits	130
SwissProt Accessions	Q96JG8, Q8WXW4, Q9BQ84, Q9BYH3, Q9BYH4	Gene names	MAGED4, KIAA1859, MAGEE1
Domain Architecture
Description	Melanoma-associated antigen D4 (MAGE-D4 antigen) (MAGE-E1 antigen).

MINT_MOUSE
θ value	0.0961366 (rank : 1077)	NC score	0.051494 (rank : 1307)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1514	Shared Neighborhood Hits	357
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

NPBL_MOUSE
θ value	0.0961366 (rank : 1078)	NC score	0.037055 (rank : 1402)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1041	Shared Neighborhood Hits	219
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

PI3R4_HUMAN
θ value	0.0961366 (rank : 1079)	NC score	0.351690 (rank : 906)
Query Neighborhood Hits	1762	Target Neighborhood Hits	534	Shared Neighborhood Hits	349
SwissProt Accessions	Q99570	Gene names	PIK3R4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein).

PI3R4_MOUSE
θ value	0.0961366 (rank : 1080)	NC score	0.366106 (rank : 894)
Query Neighborhood Hits	1762	Target Neighborhood Hits	535	Shared Neighborhood Hits	360
SwissProt Accessions	Q8VD65, Q56A65, Q8C948, Q8C9D7, Q9CVC5	Gene names	Pik3r4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4).

RP3A_HUMAN
θ value	0.0961366 (rank : 1081)	NC score	0.032025 (rank : 1435)
Query Neighborhood Hits	1762	Target Neighborhood Hits	305	Shared Neighborhood Hits	102
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

TARSH_HUMAN
θ value	0.0961366 (rank : 1082)	NC score	0.136493 (rank : 1067)
Query Neighborhood Hits	1762	Target Neighborhood Hits	768	Shared Neighborhood Hits	317
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

TULP4_MOUSE
θ value	0.0961366 (rank : 1083)	NC score	0.024408 (rank : 1502)
Query Neighborhood Hits	1762	Target Neighborhood Hits	247	Shared Neighborhood Hits	54
SwissProt Accessions	Q9JIL5, Q8CA75, Q922C2	Gene names	Tulp4, Tusp
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

ARI1A_HUMAN
θ value	0.125558 (rank : 1084)	NC score	0.037804 (rank : 1392)
Query Neighborhood Hits	1762	Target Neighborhood Hits	787	Shared Neighborhood Hits	246
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

BASI_HUMAN
θ value	0.125558 (rank : 1085)	NC score	0.262384 (rank : 984)
Query Neighborhood Hits	1762	Target Neighborhood Hits	211	Shared Neighborhood Hits	188
SwissProt Accessions	P35613, Q7Z796, Q8IZL7	Gene names	BSG
Domain Architecture
Description	Basigin precursor (Leukocyte activation antigen M6) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (5F7) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (OK blood group antigen) (CD147 antigen).

BMPR2_MOUSE
θ value	0.125558 (rank : 1086)	NC score	0.591007 (rank : 792)
Query Neighborhood Hits	1762	Target Neighborhood Hits	738	Shared Neighborhood Hits	696
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

CIC_MOUSE
θ value	0.125558 (rank : 1087)	NC score	0.046826 (rank : 1339)
Query Neighborhood Hits	1762	Target Neighborhood Hits	742	Shared Neighborhood Hits	289
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

CN092_MOUSE
θ value	0.125558 (rank : 1088)	NC score	0.021318 (rank : 1530)
Query Neighborhood Hits	1762	Target Neighborhood Hits	206	Shared Neighborhood Hits	64
SwissProt Accessions	Q8BU11, Q80UI2, Q99PN9, Q9CS16	Gene names
Domain Architecture
Description	Epidermal Langerhans cell protein LCP1.

CTDP1_MOUSE
θ value	0.125558 (rank : 1089)	NC score	0.020319 (rank : 1545)
Query Neighborhood Hits	1762	Target Neighborhood Hits	146	Shared Neighborhood Hits	50
SwissProt Accessions	Q7TSG2, Q7TSS7, Q9D4S8	Gene names	Ctdp1, Fcp1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

ESAM_HUMAN
θ value	0.125558 (rank : 1090)	NC score	0.193122 (rank : 1011)
Query Neighborhood Hits	1762	Target Neighborhood Hits	251	Shared Neighborhood Hits	186
SwissProt Accessions	Q96AP7, Q96T50	Gene names	ESAM
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

ESPL1_MOUSE
θ value	0.125558 (rank : 1091)	NC score	0.017680 (rank : 1579)
Query Neighborhood Hits	1762	Target Neighborhood Hits	67	Shared Neighborhood Hits	11
SwissProt Accessions	P60330	Gene names	Espl1, Esp1, Kiaa0165
Domain Architecture
Description	Separin (EC 3.4.22.49) (Separase) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein).

INVS_HUMAN
θ value	0.125558 (rank : 1092)	NC score	0.014957 (rank : 1614)
Query Neighborhood Hits	1762	Target Neighborhood Hits	455	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Y283, Q5W0T6, Q8IVX8, Q9BRB9, Q9Y488, Q9Y498	Gene names	INVS, INV, NPHP2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning homolog) (Nephrocystin-2).

LRC4B_HUMAN
θ value	0.125558 (rank : 1093)	NC score	0.120092 (rank : 1087)
Query Neighborhood Hits	1762	Target Neighborhood Hits	479	Shared Neighborhood Hits	207
SwissProt Accessions	Q9NT99, Q3ZCQ4, Q58F20	Gene names	LRRC4B, LRIG4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

LRC4B_MOUSE
θ value	0.125558 (rank : 1094)	NC score	0.121158 (rank : 1084)
Query Neighborhood Hits	1762	Target Neighborhood Hits	484	Shared Neighborhood Hits	210
SwissProt Accessions	P0C192	Gene names	Lrrc4b, Lrig4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

MALT1_HUMAN
θ value	0.125558 (rank : 1095)	NC score	0.305472 (rank : 941)
Query Neighborhood Hits	1762	Target Neighborhood Hits	236	Shared Neighborhood Hits	207
SwissProt Accessions	Q9UDY8, Q9NTB7, Q9ULX4	Gene names	MALT1, MLT
Domain Architecture
Description	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase).

MAP4_HUMAN
θ value	0.125558 (rank : 1096)	NC score	0.049098 (rank : 1325)
Query Neighborhood Hits	1762	Target Neighborhood Hits	428	Shared Neighborhood Hits	149
SwissProt Accessions	P27816, Q13082, Q96A76	Gene names	MAP4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

MFA3L_MOUSE
θ value	0.125558 (rank : 1097)	NC score	0.225088 (rank : 1002)
Query Neighborhood Hits	1762	Target Neighborhood Hits	214	Shared Neighborhood Hits	193
SwissProt Accessions	Q9D3X9, Q80TV6, Q8BJA9	Gene names	Mfap3l, Kiaa0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor.

SIGIR_MOUSE
θ value	0.125558 (rank : 1098)	NC score	0.062136 (rank : 1242)
Query Neighborhood Hits	1762	Target Neighborhood Hits	95	Shared Neighborhood Hits	61
SwissProt Accessions	Q9JLZ8, Q52L48	Gene names	Sigirr, Tir8
Domain Architecture	No domain graphic available
Description	Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8).

SNPC4_HUMAN
θ value	0.125558 (rank : 1099)	NC score	0.039519 (rank : 1380)
Query Neighborhood Hits	1762	Target Neighborhood Hits	589	Shared Neighborhood Hits	204
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

SRRM2_MOUSE
θ value	0.125558 (rank : 1100)	NC score	0.104217 (rank : 1114)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1470	Shared Neighborhood Hits	424
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

TGFR1_HUMAN
θ value	0.125558 (rank : 1101)	NC score	0.605619 (rank : 782)
Query Neighborhood Hits	1762	Target Neighborhood Hits	755	Shared Neighborhood Hits	734
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
θ value	0.125558 (rank : 1102)	NC score	0.605312 (rank : 783)
Query Neighborhood Hits	1762	Target Neighborhood Hits	753	Shared Neighborhood Hits	734
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

TMPSD_HUMAN
θ value	0.125558 (rank : 1103)	NC score	-0.005860 (rank : 1889)
Query Neighborhood Hits	1762	Target Neighborhood Hits	333	Shared Neighborhood Hits	68
SwissProt Accessions	Q9BYE2, Q86YM4, Q96JY8, Q9BYE1	Gene names	TMPRSS13, MSP, TMPRSS11
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

ADA2C_HUMAN
θ value	0.163984 (rank : 1104)	NC score	-0.024474 (rank : 1928)
Query Neighborhood Hits	1762	Target Neighborhood Hits	784	Shared Neighborhood Hits	10
SwissProt Accessions	P18825, P35369, Q9HB49	Gene names	ADRA2C
Domain Architecture
Description	Alpha-2C adrenergic receptor (Alpha-2C adrenoceptor) (Alpha-2C adrenoreceptor) (Alpha-2 adrenergic receptor subtype C4).

AIM1_HUMAN
θ value	0.163984 (rank : 1105)	NC score	0.024082 (rank : 1505)
Query Neighborhood Hits	1762	Target Neighborhood Hits	247	Shared Neighborhood Hits	86
SwissProt Accessions	Q9Y4K1, O00296, Q5VWJ2	Gene names	AIM1
Domain Architecture
Description	Absent in melanoma 1 protein.

CECR2_HUMAN
θ value	0.163984 (rank : 1106)	NC score	0.015436 (rank : 1607)
Query Neighborhood Hits	1762	Target Neighborhood Hits	543	Shared Neighborhood Hits	140
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

CSTFT_HUMAN
θ value	0.163984 (rank : 1107)	NC score	0.004810 (rank : 1770)
Query Neighborhood Hits	1762	Target Neighborhood Hits	292	Shared Neighborhood Hits	45
SwissProt Accessions	Q9H0L4, O75174, Q53HK6, Q7LGE8, Q8N6T1	Gene names	CSTF2T, KIAA0689
Domain Architecture	No domain graphic available
Description	Cleavage stimulation factor 64 kDa subunit, tau variant (CSTF 64 kDa subunit, tau variant) (CF-1 64 kDa subunit, tau variant) (TauCstF-64).

IQEC3_MOUSE
θ value	0.163984 (rank : 1108)	NC score	0.013006 (rank : 1635)
Query Neighborhood Hits	1762	Target Neighborhood Hits	274	Shared Neighborhood Hits	99
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

K1802_HUMAN
θ value	0.163984 (rank : 1109)	NC score	0.032542 (rank : 1428)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1378	Shared Neighborhood Hits	324
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

LRRN1_HUMAN
θ value	0.163984 (rank : 1110)	NC score	0.148553 (rank : 1057)
Query Neighborhood Hits	1762	Target Neighborhood Hits	518	Shared Neighborhood Hits	246
SwissProt Accessions	Q6UXK5, Q3LID5, Q8IYV5, Q9H8V1, Q9P231	Gene names	LRRN1, KIAA1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

LRRN1_MOUSE
θ value	0.163984 (rank : 1111)	NC score	0.143032 (rank : 1064)
Query Neighborhood Hits	1762	Target Neighborhood Hits	508	Shared Neighborhood Hits	244
SwissProt Accessions	Q61809, Q3USY1, Q69ZI0	Gene names	Lrrn1, Kiaa1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

NCOA6_MOUSE
θ value	0.163984 (rank : 1112)	NC score	0.062708 (rank : 1240)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1076	Shared Neighborhood Hits	328
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

PDZD2_HUMAN
θ value	0.163984 (rank : 1113)	NC score	0.027484 (rank : 1472)
Query Neighborhood Hits	1762	Target Neighborhood Hits	772	Shared Neighborhood Hits	201
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

PHC2_HUMAN
θ value	0.163984 (rank : 1114)	NC score	0.028197 (rank : 1465)
Query Neighborhood Hits	1762	Target Neighborhood Hits	388	Shared Neighborhood Hits	154
SwissProt Accessions	Q8IXK0, Q5T0C1, Q6NUJ6, Q6ZQR1, Q8N306, Q8TAG8, Q96BL4, Q9Y4Y7	Gene names	PHC2, EDR2, PH2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2).

SFPQ_HUMAN
θ value	0.163984 (rank : 1115)	NC score	0.058144 (rank : 1266)
Query Neighborhood Hits	1762	Target Neighborhood Hits	986	Shared Neighborhood Hits	273
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

SFR16_HUMAN
θ value	0.163984 (rank : 1116)	NC score	0.032500 (rank : 1429)
Query Neighborhood Hits	1762	Target Neighborhood Hits	178	Shared Neighborhood Hits	48
SwissProt Accessions	Q8N2M8, O96026, Q6UW71, Q96DX2	Gene names	SFRS16, SWAP2
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 16 (Suppressor of white-apricot homolog 2).

TGON2_HUMAN
θ value	0.163984 (rank : 1117)	NC score	0.053561 (rank : 1295)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1037	Shared Neighborhood Hits	256
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

TMPSD_MOUSE
θ value	0.163984 (rank : 1118)	NC score	-0.005286 (rank : 1888)
Query Neighborhood Hits	1762	Target Neighborhood Hits	334	Shared Neighborhood Hits	84
SwissProt Accessions	Q5U405, Q8CFE0, Q91VQ8	Gene names	Tmprss13, Msp
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

ZN687_HUMAN
θ value	0.163984 (rank : 1119)	NC score	-0.011625 (rank : 1906)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1244	Shared Neighborhood Hits	211
SwissProt Accessions	Q8N1G0, Q68DQ8, Q9H937, Q9P2A7	Gene names	ZNF687, KIAA1441
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

AMHR2_HUMAN
θ value	0.21417 (rank : 1120)	NC score	0.505903 (rank : 817)
Query Neighborhood Hits	1762	Target Neighborhood Hits	715	Shared Neighborhood Hits	655
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

BSN_MOUSE
θ value	0.21417 (rank : 1121)	NC score	0.078967 (rank : 1159)
Query Neighborhood Hits	1762	Target Neighborhood Hits	2057	Shared Neighborhood Hits	514
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CO039_HUMAN
θ value	0.21417 (rank : 1122)	NC score	0.050694 (rank : 1312)
Query Neighborhood Hits	1762	Target Neighborhood Hits	264	Shared Neighborhood Hits	123
SwissProt Accessions	Q6ZRI6, Q71JB1, Q7L3S0, Q8N3F2, Q96FB6, Q9NTU5	Gene names	C15orf39
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39.

CSKI2_HUMAN
θ value	0.21417 (rank : 1123)	NC score	0.040435 (rank : 1370)
Query Neighborhood Hits	1762	Target Neighborhood Hits	747	Shared Neighborhood Hits	244
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

DLG5_HUMAN
θ value	0.21417 (rank : 1124)	NC score	0.015964 (rank : 1602)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1088	Shared Neighborhood Hits	152
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

ETV3_HUMAN
θ value	0.21417 (rank : 1125)	NC score	0.015432 (rank : 1608)
Query Neighborhood Hits	1762	Target Neighborhood Hits	312	Shared Neighborhood Hits	98
SwissProt Accessions	P41162, Q8TAC8, Q9BX30	Gene names	ETV3, METS, PE1
Domain Architecture	No domain graphic available
Description	ETS translocation variant 3 (ETS-domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor).

KS6C1_HUMAN
θ value	0.21417 (rank : 1126)	NC score	0.668279 (rank : 701)
Query Neighborhood Hits	1762	Target Neighborhood Hits	682	Shared Neighborhood Hits	636
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

MLL3_HUMAN
θ value	0.21417 (rank : 1127)	NC score	0.041173 (rank : 1367)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1644	Shared Neighborhood Hits	369
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

PP16A_HUMAN
θ value	0.21417 (rank : 1128)	NC score	0.009254 (rank : 1693)
Query Neighborhood Hits	1762	Target Neighborhood Hits	340	Shared Neighborhood Hits	45
SwissProt Accessions	Q96I34	Gene names	PPP1R16A, MYPT3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase- targeting subunit 3).

PSG8_HUMAN
θ value	0.21417 (rank : 1129)	NC score	0.173464 (rank : 1029)
Query Neighborhood Hits	1762	Target Neighborhood Hits	239	Shared Neighborhood Hits	189
SwissProt Accessions	Q9UQ74, O60410	Gene names	PSG8
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 8 precursor (PSBG-8).

RUSC2_MOUSE
θ value	0.21417 (rank : 1130)	NC score	0.023299 (rank : 1514)
Query Neighborhood Hits	1762	Target Neighborhood Hits	305	Shared Neighborhood Hits	111
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

TB182_HUMAN
θ value	0.21417 (rank : 1131)	NC score	0.041718 (rank : 1365)
Query Neighborhood Hits	1762	Target Neighborhood Hits	414	Shared Neighborhood Hits	140
SwissProt Accessions	Q9C0C2	Gene names	TNKS1BP1, KIAA1741, TAB182
Domain Architecture	No domain graphic available
Description	182 kDa tankyrase 1-binding protein.

TITF1_HUMAN
θ value	0.21417 (rank : 1132)	NC score	-0.010039 (rank : 1901)
Query Neighborhood Hits	1762	Target Neighborhood Hits	332	Shared Neighborhood Hits	15
SwissProt Accessions	P43699, O14954, O14955, Q9BRJ8	Gene names	TITF1, NKX2-1, NKX2A, TTF1
Domain Architecture
Description	Thyroid transcription factor 1 (Thyroid nuclear factor 1) (TTF-1) (Homeobox protein Nkx-2.1) (Homeobox protein NK-2 homolog A).

UNC5D_HUMAN
θ value	0.21417 (rank : 1133)	NC score	0.149348 (rank : 1056)
Query Neighborhood Hits	1762	Target Neighborhood Hits	267	Shared Neighborhood Hits	177
SwissProt Accessions	Q6UXZ4, Q8WYP7	Gene names	UNC5D, KIAA1777, UNC5H4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

UNC5D_MOUSE
θ value	0.21417 (rank : 1134)	NC score	0.151196 (rank : 1051)
Query Neighborhood Hits	1762	Target Neighborhood Hits	268	Shared Neighborhood Hits	177
SwissProt Accessions	Q8K1S2	Gene names	Unc5d, Unc5h4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

ADA2C_MOUSE
θ value	0.279714 (rank : 1135)	NC score	-0.024464 (rank : 1927)
Query Neighborhood Hits	1762	Target Neighborhood Hits	792	Shared Neighborhood Hits	12
SwissProt Accessions	Q01337	Gene names	Adra2c
Domain Architecture
Description	Alpha-2C adrenergic receptor (Alpha-2C adrenoceptor) (Alpha-2C adrenoreceptor) (Alpha-2 adrenergic receptor subtype C4).

ANK2_HUMAN
θ value	0.279714 (rank : 1136)	NC score	0.037309 (rank : 1397)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1615	Shared Neighborhood Hits	364
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

BAT2_HUMAN
θ value	0.279714 (rank : 1137)	NC score	0.071169 (rank : 1198)
Query Neighborhood Hits	1762	Target Neighborhood Hits	931	Shared Neighborhood Hits	337
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

BHLH8_HUMAN
θ value	0.279714 (rank : 1138)	NC score	-0.000327 (rank : 1848)
Query Neighborhood Hits	1762	Target Neighborhood Hits	123	Shared Neighborhood Hits	15
SwissProt Accessions	Q7RTS1	Gene names	BHLHB8, MIST1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

BSN_HUMAN
θ value	0.279714 (rank : 1139)	NC score	0.078527 (rank : 1161)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1537	Shared Neighborhood Hits	425
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

EFS_MOUSE
θ value	0.279714 (rank : 1140)	NC score	0.034471 (rank : 1419)
Query Neighborhood Hits	1762	Target Neighborhood Hits	389	Shared Neighborhood Hits	130
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

FLIP1_MOUSE
θ value	0.279714 (rank : 1141)	NC score	0.014619 (rank : 1618)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1176	Shared Neighborhood Hits	145
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

GP179_HUMAN
θ value	0.279714 (rank : 1142)	NC score	0.020372 (rank : 1544)
Query Neighborhood Hits	1762	Target Neighborhood Hits	372	Shared Neighborhood Hits	103
SwissProt Accessions	Q6PRD1	Gene names	GPR179, GPR158L1
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 179 precursor (Probable G-protein coupled receptor 158-like 1).

IF39_MOUSE
θ value	0.279714 (rank : 1143)	NC score	0.026513 (rank : 1485)
Query Neighborhood Hits	1762	Target Neighborhood Hits	206	Shared Neighborhood Hits	62
SwissProt Accessions	Q8JZQ9, Q922K2	Gene names	Eif3s9
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 3 subunit 9 (eIF-3 eta) (eIF3 p116).

KS6C1_MOUSE
θ value	0.279714 (rank : 1144)	NC score	0.672284 (rank : 688)
Query Neighborhood Hits	1762	Target Neighborhood Hits	700	Shared Neighborhood Hits	640
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

LSM11_HUMAN
θ value	0.279714 (rank : 1145)	NC score	0.020727 (rank : 1537)
Query Neighborhood Hits	1762	Target Neighborhood Hits	16	Shared Neighborhood Hits	5
SwissProt Accessions	P83369, Q7Z7P0, Q8N975	Gene names	LSM11
Domain Architecture	No domain graphic available
Description	U7 snRNA-associated Sm-like protein LSm11.

MKL1_MOUSE
θ value	0.279714 (rank : 1146)	NC score	0.032708 (rank : 1426)
Query Neighborhood Hits	1762	Target Neighborhood Hits	667	Shared Neighborhood Hits	189
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

NUFP1_HUMAN
θ value	0.279714 (rank : 1147)	NC score	0.014108 (rank : 1621)
Query Neighborhood Hits	1762	Target Neighborhood Hits	193	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UHK0, Q8WVM5, Q96SG1	Gene names	NUFIP1
Domain Architecture	No domain graphic available
Description	Nuclear fragile X mental retardation-interacting protein 1 (Nuclear FMRP-interacting protein 1).

PSG2_HUMAN
θ value	0.279714 (rank : 1148)	NC score	0.162158 (rank : 1038)
Query Neighborhood Hits	1762	Target Neighborhood Hits	229	Shared Neighborhood Hits	184
SwissProt Accessions	P11465, Q8TCD9, Q9UEA4, Q9UQ78	Gene names	PSG2
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 2 precursor (PSBG-2) (Pregnancy-specific beta-1 glycoprotein E) (PS-beta-E).

STK31_HUMAN
θ value	0.279714 (rank : 1149)	NC score	0.349142 (rank : 912)
Query Neighborhood Hits	1762	Target Neighborhood Hits	570	Shared Neighborhood Hits	377
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

TXLNA_HUMAN
θ value	0.279714 (rank : 1150)	NC score	0.027797 (rank : 1471)
Query Neighborhood Hits	1762	Target Neighborhood Hits	982	Shared Neighborhood Hits	145
SwissProt Accessions	P40222, Q66K62, Q86T54, Q86T85, Q86T86, Q86Y86, Q86YW3, Q8N2Y3	Gene names	TXLNA, TXLN
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

ACD_HUMAN
θ value	0.365318 (rank : 1151)	NC score	0.029582 (rank : 1454)
Query Neighborhood Hits	1762	Target Neighborhood Hits	143	Shared Neighborhood Hits	63
SwissProt Accessions	Q96AP0, Q562H5, Q9H8F9	Gene names	ACD, PIP1, PTOP
Domain Architecture	No domain graphic available
Description	Adrenocortical dysplasia protein homolog (POT1 and TIN2-interacting protein).

AGRIN_HUMAN
θ value	0.365318 (rank : 1152)	NC score	0.020226 (rank : 1549)
Query Neighborhood Hits	1762	Target Neighborhood Hits	582	Shared Neighborhood Hits	90
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

BMPR2_HUMAN
θ value	0.365318 (rank : 1153)	NC score	0.591717 (rank : 791)
Query Neighborhood Hits	1762	Target Neighborhood Hits	736	Shared Neighborhood Hits	696
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

DDFL1_HUMAN
θ value	0.365318 (rank : 1154)	NC score	0.004755 (rank : 1772)
Query Neighborhood Hits	1762	Target Neighborhood Hits	353	Shared Neighborhood Hits	47
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

FBLN2_MOUSE
θ value	0.365318 (rank : 1155)	NC score	0.001333 (rank : 1827)
Query Neighborhood Hits	1762	Target Neighborhood Hits	505	Shared Neighborhood Hits	95
SwissProt Accessions	P37889, Q9WUI2	Gene names	Fbln2
Domain Architecture
Description	Fibulin-2 precursor.

JIP2_HUMAN
θ value	0.365318 (rank : 1156)	NC score	0.030662 (rank : 1447)
Query Neighborhood Hits	1762	Target Neighborhood Hits	288	Shared Neighborhood Hits	99
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

KLF17_HUMAN
θ value	0.365318 (rank : 1157)	NC score	-0.020824 (rank : 1919)
Query Neighborhood Hits	1762	Target Neighborhood Hits	882	Shared Neighborhood Hits	117
SwissProt Accessions	Q5JT82, Q86VQ7, Q8N805	Gene names	KLF17, ZNF393
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 17 (Zinc finger protein 393).

MUC18_HUMAN
θ value	0.365318 (rank : 1158)	NC score	0.285293 (rank : 957)
Query Neighborhood Hits	1762	Target Neighborhood Hits	275	Shared Neighborhood Hits	219
SwissProt Accessions	P43121, O95812, Q59E86, Q6PHR3, Q6ZTR2	Gene names	MCAM, MUC18
Domain Architecture
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (S-endo 1 endothelial-associated antigen) (Cell surface glycoprotein P1H12) (CD146 antigen).

MYO15_MOUSE
θ value	0.365318 (rank : 1159)	NC score	0.019788 (rank : 1553)
Query Neighborhood Hits	1762	Target Neighborhood Hits	467	Shared Neighborhood Hits	152
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

NRBP_MOUSE
θ value	0.365318 (rank : 1160)	NC score	0.467643 (rank : 824)
Query Neighborhood Hits	1762	Target Neighborhood Hits	442	Shared Neighborhood Hits	414
SwissProt Accessions	Q99J45, Q8BL77	Gene names	Nrbp1, Madm, Nrbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein (MLF1 adapter molecule) (HLS7- interacting protein kinase).

OGFR_MOUSE
θ value	0.365318 (rank : 1161)	NC score	0.032796 (rank : 1425)
Query Neighborhood Hits	1762	Target Neighborhood Hits	584	Shared Neighborhood Hits	162
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

PRP2_MOUSE
θ value	0.365318 (rank : 1162)	NC score	0.091300 (rank : 1136)
Query Neighborhood Hits	1762	Target Neighborhood Hits	347	Shared Neighborhood Hits	184
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

RN5A_MOUSE
θ value	0.365318 (rank : 1163)	NC score	0.316307 (rank : 928)
Query Neighborhood Hits	1762	Target Neighborhood Hits	899	Shared Neighborhood Hits	612
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

SC24C_HUMAN
θ value	0.365318 (rank : 1164)	NC score	0.037291 (rank : 1398)
Query Neighborhood Hits	1762	Target Neighborhood Hits	662	Shared Neighborhood Hits	210
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

UBP42_HUMAN
θ value	0.365318 (rank : 1165)	NC score	0.014809 (rank : 1616)
Query Neighborhood Hits	1762	Target Neighborhood Hits	445	Shared Neighborhood Hits	131
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

UNC5A_HUMAN
θ value	0.365318 (rank : 1166)	NC score	0.119753 (rank : 1089)
Query Neighborhood Hits	1762	Target Neighborhood Hits	198	Shared Neighborhood Hits	131
SwissProt Accessions	Q6ZN44, Q8TF26, Q96GP4	Gene names	UNC5A, KIAA1976, UNC5H1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

VMD2_HUMAN
θ value	0.365318 (rank : 1167)	NC score	0.004118 (rank : 1781)
Query Neighborhood Hits	1762	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	O76090, O75904, Q8IUR9, Q8IZ80	Gene names	VMD2
Domain Architecture
Description	Bestrophin-1 (Vitelliform macular dystrophy protein 2) (TU15B).

ZAR1_HUMAN
θ value	0.365318 (rank : 1168)	NC score	0.039868 (rank : 1378)
Query Neighborhood Hits	1762	Target Neighborhood Hits	163	Shared Neighborhood Hits	64
SwissProt Accessions	Q86SH2	Gene names	ZAR1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

CAC1B_MOUSE
θ value	0.47712 (rank : 1169)	NC score	0.005612 (rank : 1755)
Query Neighborhood Hits	1762	Target Neighborhood Hits	351	Shared Neighborhood Hits	95
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CD166_MOUSE
θ value	0.47712 (rank : 1170)	NC score	0.222083 (rank : 1003)
Query Neighborhood Hits	1762	Target Neighborhood Hits	252	Shared Neighborhood Hits	185
SwissProt Accessions	Q61490, O70136, Q8CDA5, Q8R2T0	Gene names	Alcam
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM) (DM-GRASP protein).

CTGE6_HUMAN
θ value	0.47712 (rank : 1171)	NC score	0.008403 (rank : 1709)
Query Neighborhood Hits	1762	Target Neighborhood Hits	650	Shared Neighborhood Hits	58
SwissProt Accessions	Q86UF2	Gene names	CTAGE6
Domain Architecture	No domain graphic available
Description	Protein cTAGE-6 (cTAGE family member 6).

ELOA2_HUMAN
θ value	0.47712 (rank : 1172)	NC score	0.017572 (rank : 1582)
Query Neighborhood Hits	1762	Target Neighborhood Hits	165	Shared Neighborhood Hits	49
SwissProt Accessions	Q8IYF1, Q9P2V9	Gene names	TCEB3B, TCEB3L
Domain Architecture
Description	RNA polymerase II transcription factor SIII subunit A2 (Elongin-A2) (EloA2) (Transcription elongation factor B polypeptide 3B).

FINC_HUMAN
θ value	0.47712 (rank : 1173)	NC score	0.150599 (rank : 1052)
Query Neighborhood Hits	1762	Target Neighborhood Hits	302	Shared Neighborhood Hits	149
SwissProt Accessions	P02751, O95609, O95610, Q14312, Q14325, Q14326, Q6LDP6, Q86T27, Q8IVI8, Q96KP7, Q96KP8, Q96KP9, Q9H1B8, Q9HAP3, Q9UMK2	Gene names	FN1, FN
Domain Architecture
Description	Fibronectin precursor (FN) (Cold-insoluble globulin) (CIG).

JAM1_HUMAN
θ value	0.47712 (rank : 1174)	NC score	0.286718 (rank : 955)
Query Neighborhood Hits	1762	Target Neighborhood Hits	294	Shared Neighborhood Hits	233
SwissProt Accessions	Q9Y624	Gene names	F11R, JAM1, JCAM
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet adhesion molecule 1) (PAM-1) (Platelet F11 receptor) (CD321 antigen).

KLF12_HUMAN
θ value	0.47712 (rank : 1175)	NC score	-0.024040 (rank : 1925)
Query Neighborhood Hits	1762	Target Neighborhood Hits	717	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y4X4, Q5VZM7, Q9UHZ0	Gene names	KLF12, AP2REP
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 12 (Transcriptional repressor AP-2rep).

MAP1A_HUMAN
θ value	0.47712 (rank : 1176)	NC score	0.047931 (rank : 1332)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1626	Shared Neighborhood Hits	322
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

MAP4_MOUSE
θ value	0.47712 (rank : 1177)	NC score	0.052513 (rank : 1304)
Query Neighborhood Hits	1762	Target Neighborhood Hits	409	Shared Neighborhood Hits	164
SwissProt Accessions	P27546	Gene names	Map4, Mtap4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

MEGF9_MOUSE
θ value	0.47712 (rank : 1178)	NC score	0.030887 (rank : 1443)
Query Neighborhood Hits	1762	Target Neighborhood Hits	896	Shared Neighborhood Hits	239
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

MGRN1_HUMAN
θ value	0.47712 (rank : 1179)	NC score	0.002959 (rank : 1801)
Query Neighborhood Hits	1762	Target Neighborhood Hits	192	Shared Neighborhood Hits	19
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

MILK1_MOUSE
θ value	0.47712 (rank : 1180)	NC score	0.038762 (rank : 1385)
Query Neighborhood Hits	1762	Target Neighborhood Hits	788	Shared Neighborhood Hits	275
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

MISS_MOUSE
θ value	0.47712 (rank : 1181)	NC score	0.040869 (rank : 1369)
Query Neighborhood Hits	1762	Target Neighborhood Hits	444	Shared Neighborhood Hits	160
SwissProt Accessions	Q9D7G9, Q7M749	Gene names	Mapk1ip1, Miss
Domain Architecture	No domain graphic available
Description	MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1).

MYO15_HUMAN
θ value	0.47712 (rank : 1182)	NC score	0.023437 (rank : 1511)
Query Neighborhood Hits	1762	Target Neighborhood Hits	671	Shared Neighborhood Hits	231
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

PI5PA_HUMAN
θ value	0.47712 (rank : 1183)	NC score	0.050494 (rank : 1317)
Query Neighborhood Hits	1762	Target Neighborhood Hits	749	Shared Neighborhood Hits	266
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

PI5PA_MOUSE
θ value	0.47712 (rank : 1184)	NC score	0.040077 (rank : 1375)
Query Neighborhood Hits	1762	Target Neighborhood Hits	331	Shared Neighborhood Hits	156
SwissProt Accessions	P59644	Gene names	Pib5pa
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

PSG9_HUMAN
θ value	0.47712 (rank : 1185)	NC score	0.153044 (rank : 1048)
Query Neighborhood Hits	1762	Target Neighborhood Hits	221	Shared Neighborhood Hits	182
SwissProt Accessions	Q00887, Q15236, Q15237, Q8WW78, Q9UQ73	Gene names	PSG9, PSG11
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 9 precursor (PSBG-9) (Pregnancy-specific glycoprotein 9) (Pregnancy-specific beta-1 glycoprotein B) (PS-beta-B) (PS34) (Pregnancy-specific glycoprotein 7) (PSG7).

SEM6B_HUMAN
θ value	0.47712 (rank : 1186)	NC score	0.002169 (rank : 1813)
Query Neighborhood Hits	1762	Target Neighborhood Hits	187	Shared Neighborhood Hits	53
SwissProt Accessions	Q9H3T3, Q9NRK9	Gene names	SEMA6B, SEMAZ
Domain Architecture
Description	Semaphorin-6B precursor (Semaphorin Z) (Sema Z).

SET1A_HUMAN
θ value	0.47712 (rank : 1187)	NC score	0.057992 (rank : 1271)
Query Neighborhood Hits	1762	Target Neighborhood Hits	690	Shared Neighborhood Hits	235
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

SIG12_MOUSE
θ value	0.47712 (rank : 1188)	NC score	0.126531 (rank : 1077)
Query Neighborhood Hits	1762	Target Neighborhood Hits	225	Shared Neighborhood Hits	161
SwissProt Accessions	Q91Y57	Gene names	Siglec12, Siglec5, Siglece, Siglecl1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1) (Sialic acid-binding Ig-like lectin 5) (Siglec-5) (mSiglec-E) (Myeloid inhibitory siglec) (MIS).

T22D4_HUMAN
θ value	0.47712 (rank : 1189)	NC score	0.043049 (rank : 1354)
Query Neighborhood Hits	1762	Target Neighborhood Hits	403	Shared Neighborhood Hits	149
SwissProt Accessions	Q9Y3Q8	Gene names	TSC22D4, TILZ2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1).

UNC5A_MOUSE
θ value	0.47712 (rank : 1190)	NC score	0.103826 (rank : 1115)
Query Neighborhood Hits	1762	Target Neighborhood Hits	203	Shared Neighborhood Hits	127
SwissProt Accessions	Q8K1S4, Q6PEF7, Q80T71	Gene names	Unc5a, Kiaa1976, Unc5h1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

WAPL_HUMAN
θ value	0.47712 (rank : 1191)	NC score	0.016485 (rank : 1596)
Query Neighborhood Hits	1762	Target Neighborhood Hits	122	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z5K2, Q5VSK5, Q8IX10, Q92549	Gene names	WAPAL, FOE, KIAA0261, WAPL
Domain Architecture	No domain graphic available
Description	Wings apart-like protein homolog (Friend of EBNA2 protein).

BASI_MOUSE
θ value	0.62314 (rank : 1192)	NC score	0.254470 (rank : 991)
Query Neighborhood Hits	1762	Target Neighborhood Hits	238	Shared Neighborhood Hits	200
SwissProt Accessions	P18572, Q6LDB0, Q7TSC0	Gene names	Bsg
Domain Architecture
Description	Basigin precursor (Basic immunoglobulin superfamily) (Membrane glycoprotein gp42) (HT7 antigen) (CD147 antigen).

BASP_HUMAN
θ value	0.62314 (rank : 1193)	NC score	0.073814 (rank : 1184)
Query Neighborhood Hits	1762	Target Neighborhood Hits	321	Shared Neighborhood Hits	122
SwissProt Accessions	P80723, O43596, Q5U0S0	Gene names	BASP1, NAP22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

CEAM8_HUMAN
θ value	0.62314 (rank : 1194)	NC score	0.176390 (rank : 1023)
Query Neighborhood Hits	1762	Target Neighborhood Hits	264	Shared Neighborhood Hits	206
SwissProt Accessions	P31997, O60399, Q16574	Gene names	CEACAM8, CGM6
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 8 precursor (Carcinoembryonic antigen CGM6) (Nonspecific cross-reacting antigen NCA-95) (CD67 antigen) (CD66b antigen).

CJ108_HUMAN
θ value	0.62314 (rank : 1195)	NC score	0.024189 (rank : 1503)
Query Neighborhood Hits	1762	Target Neighborhood Hits	165	Shared Neighborhood Hits	57
SwissProt Accessions	Q8N8Z3	Gene names	C10orf108
Domain Architecture	No domain graphic available
Description	Putative uncharacterized protein C10orf108.

CS007_MOUSE
θ value	0.62314 (rank : 1196)	NC score	0.035934 (rank : 1408)
Query Neighborhood Hits	1762	Target Neighborhood Hits	464	Shared Neighborhood Hits	153
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

FOXN1_HUMAN
θ value	0.62314 (rank : 1197)	NC score	0.002300 (rank : 1811)
Query Neighborhood Hits	1762	Target Neighborhood Hits	377	Shared Neighborhood Hits	113
SwissProt Accessions	O15353, O15352	Gene names	FOXN1, WHN
Domain Architecture
Description	Forkhead box protein N1 (Transcription factor winged-helix nude).

FRS3_MOUSE
θ value	0.62314 (rank : 1198)	NC score	0.007286 (rank : 1727)
Query Neighborhood Hits	1762	Target Neighborhood Hits	168	Shared Neighborhood Hits	56
SwissProt Accessions	Q91WJ0	Gene names	Frs3, Frs2b
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (FRS2-beta).

GAK12_HUMAN
θ value	0.62314 (rank : 1199)	NC score	0.015634 (rank : 1605)
Query Neighborhood Hits	1762	Target Neighborhood Hits	374	Shared Neighborhood Hits	111
SwissProt Accessions	P63130, Q9UKI0	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q22 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K102 Gag protein) (HERV-K(III) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK5_HUMAN
θ value	0.62314 (rank : 1200)	NC score	0.017180 (rank : 1587)
Query Neighborhood Hits	1762	Target Neighborhood Hits	429	Shared Neighborhood Hits	128
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK6_HUMAN
θ value	0.62314 (rank : 1201)	NC score	0.017739 (rank : 1576)
Query Neighborhood Hits	1762	Target Neighborhood Hits	392	Shared Neighborhood Hits	125
SwissProt Accessions	P62685	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_8p23.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K115 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GCP_HUMAN
θ value	0.62314 (rank : 1202)	NC score	0.012687 (rank : 1640)
Query Neighborhood Hits	1762	Target Neighborhood Hits	4	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NPF4	Gene names	OSGEP, GCPL1
Domain Architecture
Description	Probable O-sialoglycoprotein endopeptidase (EC 3.4.24.57) (hOSGEP).

HXD9_HUMAN
θ value	0.62314 (rank : 1203)	NC score	-0.011604 (rank : 1905)
Query Neighborhood Hits	1762	Target Neighborhood Hits	352	Shared Neighborhood Hits	21
SwissProt Accessions	P28356	Gene names	HOXD9, HOX4C
Domain Architecture
Description	Homeobox protein Hox-D9 (Hox-4C) (Hox-5.2).

IL3RB_HUMAN
θ value	0.62314 (rank : 1204)	NC score	0.020233 (rank : 1548)
Query Neighborhood Hits	1762	Target Neighborhood Hits	163	Shared Neighborhood Hits	67
SwissProt Accessions	P32927	Gene names	CSF2RB, IL3RB, IL5RB
Domain Architecture
Description	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen) (CDw131).

MA1C1_HUMAN
θ value	0.62314 (rank : 1205)	NC score	0.002824 (rank : 1802)
Query Neighborhood Hits	1762	Target Neighborhood Hits	21	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NR34, Q9Y545	Gene names	MAN1C1, MAN1A3, MAN1C
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IC) (Alpha-1,2-mannosidase IC) (Mannosidase alpha class 1C member 1) (HMIC).

MTSS1_HUMAN
θ value	0.62314 (rank : 1206)	NC score	0.034490 (rank : 1418)
Query Neighborhood Hits	1762	Target Neighborhood Hits	504	Shared Neighborhood Hits	137
SwissProt Accessions	O43312, Q8TCA2, Q96RX2	Gene names	MTSS1, KIAA0429, MIM
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein) (Metastasis suppressor YGL-1).

PHXR5_MOUSE
θ value	0.62314 (rank : 1207)	NC score	0.016909 (rank : 1591)
Query Neighborhood Hits	1762	Target Neighborhood Hits	102	Shared Neighborhood Hits	19
SwissProt Accessions	P08399	Gene names	Phxr5, Per
Domain Architecture	No domain graphic available
Description	Per-hexamer repeat protein 5.

PSL1_HUMAN
θ value	0.62314 (rank : 1208)	NC score	0.038091 (rank : 1390)
Query Neighborhood Hits	1762	Target Neighborhood Hits	650	Shared Neighborhood Hits	215
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

RNF6_HUMAN
θ value	0.62314 (rank : 1209)	NC score	0.001365 (rank : 1825)
Query Neighborhood Hits	1762	Target Neighborhood Hits	157	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y252, Q9UF41	Gene names	RNF6
Domain Architecture
Description	RING finger protein 6 (RING-H2 protein).

RP3A_MOUSE
θ value	0.62314 (rank : 1210)	NC score	0.033236 (rank : 1424)
Query Neighborhood Hits	1762	Target Neighborhood Hits	510	Shared Neighborhood Hits	176
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

RPGF1_HUMAN
θ value	0.62314 (rank : 1211)	NC score	0.006706 (rank : 1737)
Query Neighborhood Hits	1762	Target Neighborhood Hits	262	Shared Neighborhood Hits	73
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

SYN3_MOUSE
θ value	0.62314 (rank : 1212)	NC score	0.025490 (rank : 1491)
Query Neighborhood Hits	1762	Target Neighborhood Hits	200	Shared Neighborhood Hits	101
SwissProt Accessions	Q8JZP2	Gene names	Syn3
Domain Architecture	No domain graphic available
Description	Synapsin-3 (Synapsin III).

TACT_HUMAN
θ value	0.62314 (rank : 1213)	NC score	0.030791 (rank : 1446)
Query Neighborhood Hits	1762	Target Neighborhood Hits	100	Shared Neighborhood Hits	37
SwissProt Accessions	P40200	Gene names	CD96
Domain Architecture	No domain graphic available
Description	T-cell surface protein tactile precursor (T cell-activated increased late expression protein) (CD96 antigen).

TENS4_HUMAN
θ value	0.62314 (rank : 1214)	NC score	0.034577 (rank : 1417)
Query Neighborhood Hits	1762	Target Neighborhood Hits	214	Shared Neighborhood Hits	78
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

VSIG4_HUMAN
θ value	0.62314 (rank : 1215)	NC score	0.230373 (rank : 1001)
Query Neighborhood Hits	1762	Target Neighborhood Hits	236	Shared Neighborhood Hits	184
SwissProt Accessions	Q9Y279, Q6UXI4	Gene names	VSIG4, Z39IG
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 4 precursor (Protein Z39Ig).

WAPL_MOUSE
θ value	0.62314 (rank : 1216)	NC score	0.012784 (rank : 1638)
Query Neighborhood Hits	1762	Target Neighborhood Hits	158	Shared Neighborhood Hits	31
SwissProt Accessions	Q65Z40, Q6ZQE9	Gene names	Wapal, Kiaa0261, Wapl
Domain Architecture	No domain graphic available
Description	Wings apart-like protein homolog (Dioxin-inducible factor 2) (DIF-2).

XKR5_MOUSE
θ value	0.62314 (rank : 1217)	NC score	0.007577 (rank : 1722)
Query Neighborhood Hits	1762	Target Neighborhood Hits	89	Shared Neighborhood Hits	18
SwissProt Accessions	Q5GH66	Gene names	Xkr5, Xrg5
Domain Architecture	No domain graphic available
Description	XK-related protein 5.

ZN217_HUMAN
θ value	0.62314 (rank : 1218)	NC score	-0.021498 (rank : 1920)
Query Neighborhood Hits	1762	Target Neighborhood Hits	905	Shared Neighborhood Hits	109
SwissProt Accessions	O75362	Gene names	ZNF217, ZABC1
Domain Architecture	No domain graphic available
Description	Zinc finger protein 217.

BASP_MOUSE
θ value	0.813845 (rank : 1219)	NC score	0.074984 (rank : 1180)
Query Neighborhood Hits	1762	Target Neighborhood Hits	260	Shared Neighborhood Hits	114
SwissProt Accessions	Q91XV3	Gene names	Basp1, Nap22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

BCL3_MOUSE
θ value	0.813845 (rank : 1220)	NC score	0.006695 (rank : 1739)
Query Neighborhood Hits	1762	Target Neighborhood Hits	388	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z2F6	Gene names	Bcl3
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 3-encoded protein homolog (Protein Bcl-3).

BCL9_HUMAN
θ value	0.813845 (rank : 1221)	NC score	0.039676 (rank : 1379)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1008	Shared Neighborhood Hits	283
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

DEN2C_MOUSE
θ value	0.813845 (rank : 1222)	NC score	0.001342 (rank : 1826)
Query Neighborhood Hits	1762	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	Q6P9P8, Q3T9X2, Q3UV30, Q80V46	Gene names	Dennd2c
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2C.

DIDO1_HUMAN
θ value	0.813845 (rank : 1223)	NC score	0.035368 (rank : 1412)
Query Neighborhood Hits	1762	Target Neighborhood Hits	960	Shared Neighborhood Hits	257
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

DYN1_HUMAN
θ value	0.813845 (rank : 1224)	NC score	0.017657 (rank : 1580)
Query Neighborhood Hits	1762	Target Neighborhood Hits	216	Shared Neighborhood Hits	107
SwissProt Accessions	Q05193	Gene names	DNM1, DNM
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

DYN1_MOUSE
θ value	0.813845 (rank : 1225)	NC score	0.012587 (rank : 1642)
Query Neighborhood Hits	1762	Target Neighborhood Hits	168	Shared Neighborhood Hits	72
SwissProt Accessions	P39053, Q61358, Q61359, Q61360, Q8JZZ4, Q9CSY7, Q9QXX1	Gene names	Dnm1, Dnm
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

EGR2_MOUSE
θ value	0.813845 (rank : 1226)	NC score	-0.025030 (rank : 1931)
Query Neighborhood Hits	1762	Target Neighborhood Hits	745	Shared Neighborhood Hits	56
SwissProt Accessions	P08152	Gene names	Egr2, Egr-2, Krox-20, Zfp-25
Domain Architecture	No domain graphic available
Description	Early growth response protein 2 (EGR-2) (Krox-20 protein).

EHMT2_MOUSE
θ value	0.813845 (rank : 1227)	NC score	0.011346 (rank : 1668)
Query Neighborhood Hits	1762	Target Neighborhood Hits	750	Shared Neighborhood Hits	163
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

EI2BD_HUMAN
θ value	0.813845 (rank : 1228)	NC score	0.011658 (rank : 1662)
Query Neighborhood Hits	1762	Target Neighborhood Hits	34	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UI10, Q5BJF4, Q9BUV9, Q9UBG4, Q9UIQ9, Q9UJ95	Gene names	EIF2B4, EIF2BD
Domain Architecture
Description	Translation initiation factor eIF-2B subunit delta (eIF-2B GDP-GTP exchange factor subunit delta).

FLIP1_HUMAN
θ value	0.813845 (rank : 1229)	NC score	0.016283 (rank : 1599)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1405	Shared Neighborhood Hits	154
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

GA2L1_MOUSE
θ value	0.813845 (rank : 1230)	NC score	0.023765 (rank : 1507)
Query Neighborhood Hits	1762	Target Neighborhood Hits	114	Shared Neighborhood Hits	56
SwissProt Accessions	Q8JZP9, Q5SVG0, Q8K573	Gene names	Gas2l1
Domain Architecture	No domain graphic available
Description	GAS2-like protein 1 (Growth arrest-specific 2-like 1).

GAK10_HUMAN
θ value	0.813845 (rank : 1231)	NC score	0.014928 (rank : 1615)
Query Neighborhood Hits	1762	Target Neighborhood Hits	289	Shared Neighborhood Hits	98
SwissProt Accessions	P87889, P10263, P10264, Q69385, Q9UKH6	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_5q33.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K10 Gag protein) (HERV-K107 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GCP_MOUSE
θ value	0.813845 (rank : 1232)	NC score	0.012239 (rank : 1651)
Query Neighborhood Hits	1762	Target Neighborhood Hits	4	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BWU5, Q99LN8	Gene names	Osgep
Domain Architecture
Description	Probable O-sialoglycoprotein endopeptidase (EC 3.4.24.57) (mOsgep).

IL1R1_HUMAN
θ value	0.813845 (rank : 1233)	NC score	0.133486 (rank : 1072)
Query Neighborhood Hits	1762	Target Neighborhood Hits	140	Shared Neighborhood Hits	116
SwissProt Accessions	P14778	Gene names	IL1R1, IL1R, IL1RA, IL1RT1
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (IL-1RT1) (IL-1R- alpha) (p80) (CD121a antigen).

K0179_HUMAN
θ value	0.813845 (rank : 1234)	NC score	0.009982 (rank : 1686)
Query Neighborhood Hits	1762	Target Neighborhood Hits	81	Shared Neighborhood Hits	28
SwissProt Accessions	Q14684, Q8TBZ4	Gene names	KIAA0179
Domain Architecture
Description	Protein KIAA0179.

K1543_HUMAN
θ value	0.813845 (rank : 1235)	NC score	0.044424 (rank : 1347)
Query Neighborhood Hits	1762	Target Neighborhood Hits	435	Shared Neighborhood Hits	172
SwissProt Accessions	Q9P1Y5, Q8NDF1	Gene names	KIAA1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

LARP4_HUMAN
θ value	0.813845 (rank : 1236)	NC score	0.015067 (rank : 1612)
Query Neighborhood Hits	1762	Target Neighborhood Hits	69	Shared Neighborhood Hits	19
SwissProt Accessions	Q71RC2, Q5CZ97, Q96NF9	Gene names	LARP4
Domain Architecture	No domain graphic available
Description	La-related protein 4 (La ribonucleoprotein domain family member 4).

LNK_HUMAN
θ value	0.813845 (rank : 1237)	NC score	0.041948 (rank : 1364)
Query Neighborhood Hits	1762	Target Neighborhood Hits	151	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LRC24_MOUSE
θ value	0.813845 (rank : 1238)	NC score	0.118683 (rank : 1092)
Query Neighborhood Hits	1762	Target Neighborhood Hits	387	Shared Neighborhood Hits	190
SwissProt Accessions	Q8BHA1	Gene names	Lrrc24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

MAP1B_HUMAN
θ value	0.813845 (rank : 1239)	NC score	0.040189 (rank : 1374)
Query Neighborhood Hits	1762	Target Neighborhood Hits	903	Shared Neighborhood Hits	165
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

MKL1_HUMAN
θ value	0.813845 (rank : 1240)	NC score	0.022755 (rank : 1519)
Query Neighborhood Hits	1762	Target Neighborhood Hits	232	Shared Neighborhood Hits	82
SwissProt Accessions	Q969V6, Q8TCL1, Q96SC5, Q96SC6, Q9P2B0	Gene names	MKL1, KIAA1438, MAL
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein).

MUCM_MOUSE
θ value	0.813845 (rank : 1241)	NC score	0.020699 (rank : 1539)
Query Neighborhood Hits	1762	Target Neighborhood Hits	242	Shared Neighborhood Hits	41
SwissProt Accessions	P01873	Gene names
Domain Architecture	No domain graphic available
Description	Ig mu chain C region membrane-bound form.

MUC_MOUSE
θ value	0.813845 (rank : 1242)	NC score	0.021090 (rank : 1532)
Query Neighborhood Hits	1762	Target Neighborhood Hits	242	Shared Neighborhood Hits	42
SwissProt Accessions	P01872	Gene names
Domain Architecture	No domain graphic available
Description	Ig mu chain C region secreted form.

PECA1_MOUSE
θ value	0.813845 (rank : 1243)	NC score	0.118814 (rank : 1091)
Query Neighborhood Hits	1762	Target Neighborhood Hits	126	Shared Neighborhood Hits	98
SwissProt Accessions	Q08481	Gene names	Pecam1, Pecam, Pecam-1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (CD31 antigen).

RASL1_MOUSE
θ value	0.813845 (rank : 1244)	NC score	0.028771 (rank : 1464)
Query Neighborhood Hits	1762	Target Neighborhood Hits	148	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

RFA1_MOUSE
θ value	0.813845 (rank : 1245)	NC score	0.007500 (rank : 1723)
Query Neighborhood Hits	1762	Target Neighborhood Hits	16	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VEE4, Q3TEJ8	Gene names	Rpa1
Domain Architecture	No domain graphic available
Description	Replication protein A 70 kDa DNA-binding subunit (RP-A) (RF-A) (Replication factor-A protein 1) (p70).

SEM6B_MOUSE
θ value	0.813845 (rank : 1246)	NC score	0.002344 (rank : 1810)
Query Neighborhood Hits	1762	Target Neighborhood Hits	200	Shared Neighborhood Hits	48
SwissProt Accessions	O54951	Gene names	Sema6b, Seman
Domain Architecture
Description	Semaphorin-6B precursor (Semaphorin VIB) (Sema VIB) (Semaphorin N) (Sema N).

SOX6_HUMAN
θ value	0.813845 (rank : 1247)	NC score	0.010688 (rank : 1677)
Query Neighborhood Hits	1762	Target Neighborhood Hits	332	Shared Neighborhood Hits	65
SwissProt Accessions	P35712, Q9BXQ3, Q9BXQ4, Q9BXQ5, Q9H0I8	Gene names	SOX6
Domain Architecture
Description	Transcription factor SOX-6.

STK31_MOUSE
θ value	0.813845 (rank : 1248)	NC score	0.295539 (rank : 945)
Query Neighborhood Hits	1762	Target Neighborhood Hits	474	Shared Neighborhood Hits	307
SwissProt Accessions	Q99MW1	Gene names	Stk31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1).

TBC10_HUMAN
θ value	0.813845 (rank : 1249)	NC score	0.008550 (rank : 1705)
Query Neighborhood Hits	1762	Target Neighborhood Hits	64	Shared Neighborhood Hits	22
SwissProt Accessions	Q9BXI6, O76053, Q543A2	Gene names	TBC1D10A, EPI64, TBC1D10
Domain Architecture
Description	TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein).

UNC5B_HUMAN
θ value	0.813845 (rank : 1250)	NC score	0.111722 (rank : 1102)
Query Neighborhood Hits	1762	Target Neighborhood Hits	225	Shared Neighborhood Hits	136
SwissProt Accessions	Q8IZJ1, Q86SN3, Q8N1Y2, Q9H9F3	Gene names	UNC5B, P53RDL1, UNC5H2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2) (p53-regulated receptor for death and life protein 1).

VGLL1_HUMAN
θ value	0.813845 (rank : 1251)	NC score	0.013596 (rank : 1625)
Query Neighborhood Hits	1762	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	Q99990	Gene names	VGLL1, TDU
Domain Architecture	No domain graphic available
Description	Transcription cofactor vestigial-like protein 1 (Vgl-1) (Protein TONDU).

ZDHC8_MOUSE
θ value	0.813845 (rank : 1252)	NC score	0.001828 (rank : 1819)
Query Neighborhood Hits	1762	Target Neighborhood Hits	243	Shared Neighborhood Hits	69
SwissProt Accessions	Q5Y5T5, Q7TNF7	Gene names	Zdhhc8
Domain Architecture	No domain graphic available
Description	Probable palmitoyltransferase ZDHHC8 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 8) (DHHC-8).

ZN385_HUMAN
θ value	0.813845 (rank : 1253)	NC score	0.024860 (rank : 1499)
Query Neighborhood Hits	1762	Target Neighborhood Hits	614	Shared Neighborhood Hits	177
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

ZN516_MOUSE
θ value	0.813845 (rank : 1254)	NC score	-0.019108 (rank : 1914)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1197	Shared Neighborhood Hits	186
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

ADA12_MOUSE
θ value	1.06291 (rank : 1255)	NC score	-0.000250 (rank : 1846)
Query Neighborhood Hits	1762	Target Neighborhood Hits	474	Shared Neighborhood Hits	124
SwissProt Accessions	Q61824	Gene names	Adam12, Mltna
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

AL2S4_MOUSE
θ value	1.06291 (rank : 1256)	NC score	0.029200 (rank : 1461)
Query Neighborhood Hits	1762	Target Neighborhood Hits	193	Shared Neighborhood Hits	61
SwissProt Accessions	Q3V0J1, Q3TIS2	Gene names	Als2cr4
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog.

APXL_HUMAN
θ value	1.06291 (rank : 1257)	NC score	0.036193 (rank : 1407)
Query Neighborhood Hits	1762	Target Neighborhood Hits	553	Shared Neighborhood Hits	144
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

BTBDC_HUMAN
θ value	1.06291 (rank : 1258)	NC score	0.030288 (rank : 1449)
Query Neighborhood Hits	1762	Target Neighborhood Hits	248	Shared Neighborhood Hits	70
SwissProt Accessions	Q8IY92, Q96JP1	Gene names	BTBD12, KIAA1784
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 12.

CEAM6_HUMAN
θ value	1.06291 (rank : 1259)	NC score	0.200566 (rank : 1009)
Query Neighborhood Hits	1762	Target Neighborhood Hits	308	Shared Neighborhood Hits	223
SwissProt Accessions	P40199, Q14920	Gene names	CEACAM6, NCA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 6 precursor (Normal cross-reacting antigen) (Nonspecific crossreacting antigen) (CD66c antigen).

CSPG5_MOUSE
θ value	1.06291 (rank : 1260)	NC score	0.017974 (rank : 1572)
Query Neighborhood Hits	1762	Target Neighborhood Hits	211	Shared Neighborhood Hits	70
SwissProt Accessions	Q71M36, Q71M37, Q7TNT8, Q8BPJ5, Q9QY32	Gene names	Cspg5, Caleb, Ngc
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 5 precursor (Neuroglycan C) (Acidic leucine-rich EGF-like domain-containing brain protein).

ENSA_HUMAN
θ value	1.06291 (rank : 1261)	NC score	0.008447 (rank : 1707)
Query Neighborhood Hits	1762	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	O43768, Q9NRZ0	Gene names	ENSA
Domain Architecture
Description	Alpha-endosulfine (ARPP-19e).

GAK11_HUMAN
θ value	1.06291 (rank : 1262)	NC score	0.017116 (rank : 1589)
Query Neighborhood Hits	1762	Target Neighborhood Hits	409	Shared Neighborhood Hits	127
SwissProt Accessions	P63145, Q9UKI1	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_22q11.21 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K101 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK2_HUMAN
θ value	1.06291 (rank : 1263)	NC score	0.016564 (rank : 1595)
Query Neighborhood Hits	1762	Target Neighborhood Hits	406	Shared Neighborhood Hits	124
SwissProt Accessions	Q7LDI9, Q9UKH5, Q9Y6I1, Q9YNA6, Q9YNB0	Gene names	ERVK6
Domain Architecture	No domain graphic available
Description	HERV-K_7p22.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K(C7) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK4_HUMAN
θ value	1.06291 (rank : 1264)	NC score	0.017222 (rank : 1586)
Query Neighborhood Hits	1762	Target Neighborhood Hits	415	Shared Neighborhood Hits	128
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

HCLS1_MOUSE
θ value	1.06291 (rank : 1265)	NC score	0.026889 (rank : 1478)
Query Neighborhood Hits	1762	Target Neighborhood Hits	329	Shared Neighborhood Hits	107
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HNF3B_HUMAN
θ value	1.06291 (rank : 1266)	NC score	-0.004056 (rank : 1884)
Query Neighborhood Hits	1762	Target Neighborhood Hits	106	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y261, Q8WUW4, Q96DF7	Gene names	FOXA2, HNF3B, TCF3B
Domain Architecture
Description	Hepatocyte nuclear factor 3-beta (HNF-3B) (Forkhead box protein A2).

HRSL5_HUMAN
θ value	1.06291 (rank : 1267)	NC score	0.009986 (rank : 1685)
Query Neighborhood Hits	1762	Target Neighborhood Hits	26	Shared Neighborhood Hits	8
SwissProt Accessions	Q96KN8	Gene names	HRASLS5, HRLP5
Domain Architecture
Description	HRAS-like suppressor 5 (H-rev107-like protein 5).

IASPP_HUMAN
θ value	1.06291 (rank : 1268)	NC score	0.048836 (rank : 1327)
Query Neighborhood Hits	1762	Target Neighborhood Hits	688	Shared Neighborhood Hits	201
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IRAK1_HUMAN
θ value	1.06291 (rank : 1269)	NC score	0.686781 (rank : 655)
Query Neighborhood Hits	1762	Target Neighborhood Hits	820	Shared Neighborhood Hits	767
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

IRAK3_HUMAN
θ value	1.06291 (rank : 1270)	NC score	0.586922 (rank : 797)
Query Neighborhood Hits	1762	Target Neighborhood Hits	644	Shared Neighborhood Hits	620
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

JPH2_MOUSE
θ value	1.06291 (rank : 1271)	NC score	0.029203 (rank : 1460)
Query Neighborhood Hits	1762	Target Neighborhood Hits	279	Shared Neighborhood Hits	114
SwissProt Accessions	Q9ET78, Q9ET79	Gene names	Jph2, Jp2
Domain Architecture	No domain graphic available
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

LAD1_MOUSE
θ value	1.06291 (rank : 1272)	NC score	0.050505 (rank : 1316)
Query Neighborhood Hits	1762	Target Neighborhood Hits	391	Shared Neighborhood Hits	128
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

MAGI2_HUMAN
θ value	1.06291 (rank : 1273)	NC score	0.012123 (rank : 1652)
Query Neighborhood Hits	1762	Target Neighborhood Hits	373	Shared Neighborhood Hits	91
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MAP1B_MOUSE
θ value	1.06291 (rank : 1274)	NC score	0.037060 (rank : 1401)
Query Neighborhood Hits	1762	Target Neighborhood Hits	977	Shared Neighborhood Hits	171
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

MKL2_MOUSE
θ value	1.06291 (rank : 1275)	NC score	0.017649 (rank : 1581)
Query Neighborhood Hits	1762	Target Neighborhood Hits	269	Shared Neighborhood Hits	66
SwissProt Accessions	P59759	Gene names	Mkl2, Mrtfb
Domain Architecture
Description	MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B).

MY18B_HUMAN
θ value	1.06291 (rank : 1276)	NC score	0.019237 (rank : 1558)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1299	Shared Neighborhood Hits	194
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

NRX2A_HUMAN
θ value	1.06291 (rank : 1277)	NC score	0.016121 (rank : 1600)
Query Neighborhood Hits	1762	Target Neighborhood Hits	614	Shared Neighborhood Hits	153
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

NRX2B_HUMAN
θ value	1.06291 (rank : 1278)	NC score	0.014316 (rank : 1619)
Query Neighborhood Hits	1762	Target Neighborhood Hits	481	Shared Neighborhood Hits	141
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

NU214_HUMAN
θ value	1.06291 (rank : 1279)	NC score	0.046009 (rank : 1342)
Query Neighborhood Hits	1762	Target Neighborhood Hits	657	Shared Neighborhood Hits	181
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

PKCB1_HUMAN
θ value	1.06291 (rank : 1280)	NC score	0.012549 (rank : 1644)
Query Neighborhood Hits	1762	Target Neighborhood Hits	488	Shared Neighborhood Hits	96
SwissProt Accessions	Q9ULU4, Q13517, Q4JJ94, Q4JJ95, Q5TH09, Q6MZM1, Q8WXC5, Q9H1F3, Q9H1F4, Q9H1F5, Q9H1L8, Q9H1L9, Q9H2G5, Q9NYN3, Q9UIX6	Gene names	PRKCBP1, KIAA1125, RACK7, ZMYND8
Domain Architecture
Description	Protein kinase C-binding protein 1 (Rack7) (Cutaneous T-cell lymphoma- associated antigen se14-3) (CTCL tumor antigen se14-3) (Zinc finger MYND domain-containing protein 8).

PSG4_HUMAN
θ value	1.06291 (rank : 1281)	NC score	0.171031 (rank : 1032)
Query Neighborhood Hits	1762	Target Neighborhood Hits	243	Shared Neighborhood Hits	192
SwissProt Accessions	Q00888, Q13047, Q13048, Q15234, Q15240, Q9UQ76	Gene names	PSG4, CGM4, PSG9
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 4 precursor (PSBG-4) (PSBG-9).

RFIP1_MOUSE
θ value	1.06291 (rank : 1282)	NC score	0.013256 (rank : 1632)
Query Neighborhood Hits	1762	Target Neighborhood Hits	152	Shared Neighborhood Hits	44
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

RP1L1_HUMAN
θ value	1.06291 (rank : 1283)	NC score	0.055241 (rank : 1285)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1072	Shared Neighborhood Hits	252
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

RU1C_HUMAN
θ value	1.06291 (rank : 1284)	NC score	0.027029 (rank : 1476)
Query Neighborhood Hits	1762	Target Neighborhood Hits	81	Shared Neighborhood Hits	37
SwissProt Accessions	P09234	Gene names	SNRPC
Domain Architecture
Description	U1 small nuclear ribonucleoprotein C (U1 snRNP protein C) (U1C protein) (U1-C).

RU1C_MOUSE
θ value	1.06291 (rank : 1285)	NC score	0.027799 (rank : 1470)
Query Neighborhood Hits	1762	Target Neighborhood Hits	83	Shared Neighborhood Hits	39
SwissProt Accessions	Q62241	Gene names	Snrp1c, Snrpc
Domain Architecture
Description	U1 small nuclear ribonucleoprotein C (U1 snRNP protein C) (U1C protein) (U1-C).

SEM6D_MOUSE
θ value	1.06291 (rank : 1286)	NC score	0.000969 (rank : 1832)
Query Neighborhood Hits	1762	Target Neighborhood Hits	161	Shared Neighborhood Hits	36
SwissProt Accessions	Q76KF0, Q76KF1, Q76KF2, Q76KF3, Q76KF4, Q80TD0	Gene names	Sema6d, Kiaa1479
Domain Architecture	No domain graphic available
Description	Semaphorin-6D precursor.

SF01_MOUSE
θ value	1.06291 (rank : 1287)	NC score	0.038533 (rank : 1387)
Query Neighborhood Hits	1762	Target Neighborhood Hits	240	Shared Neighborhood Hits	119
SwissProt Accessions	Q64213, O08817, P70167, Q61454, Q921Z4	Gene names	Sf1, Zfm1, Zfp162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (mZFM) (Zinc finger gene in MEN1 locus) (Mammalian branch point- binding protein mBBP) (BBP) (CW17).

SOX5_HUMAN
θ value	1.06291 (rank : 1288)	NC score	0.008614 (rank : 1704)
Query Neighborhood Hits	1762	Target Neighborhood Hits	219	Shared Neighborhood Hits	34
SwissProt Accessions	P35711, Q86UK8, Q8J017, Q8J018, Q8J019, Q8J020, Q8N1D9, Q8N7E0, Q8TEA4	Gene names	SOX5
Domain Architecture
Description	Transcription factor SOX-5.

SOX5_MOUSE
θ value	1.06291 (rank : 1289)	NC score	0.007707 (rank : 1719)
Query Neighborhood Hits	1762	Target Neighborhood Hits	196	Shared Neighborhood Hits	30
SwissProt Accessions	P35710, O88184, O89018	Gene names	Sox5, Sox-5
Domain Architecture
Description	Transcription factor SOX-5.

TBC10_MOUSE
θ value	1.06291 (rank : 1290)	NC score	0.008150 (rank : 1712)
Query Neighborhood Hits	1762	Target Neighborhood Hits	94	Shared Neighborhood Hits	30
SwissProt Accessions	P58802	Gene names	Tbc1d10a, Epi64, Tbc1d10
Domain Architecture
Description	TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein).

UBQL3_HUMAN
θ value	1.06291 (rank : 1291)	NC score	0.010762 (rank : 1675)
Query Neighborhood Hits	1762	Target Neighborhood Hits	141	Shared Neighborhood Hits	48
SwissProt Accessions	Q9H347, Q9NRE0	Gene names	UBQLN3
Domain Architecture
Description	Ubiquilin-3.

VINEX_MOUSE
θ value	1.06291 (rank : 1292)	NC score	0.028066 (rank : 1467)
Query Neighborhood Hits	1762	Target Neighborhood Hits	286	Shared Neighborhood Hits	76
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ZN509_MOUSE
θ value	1.06291 (rank : 1293)	NC score	-0.026803 (rank : 1938)
Query Neighborhood Hits	1762	Target Neighborhood Hits	990	Shared Neighborhood Hits	95
SwissProt Accessions	Q8BXX2, Q8CID4, Q8K2Z6	Gene names	Znf509, Zfp509
Domain Architecture	No domain graphic available
Description	Zinc finger protein 509.

ZSCA1_HUMAN
θ value	1.06291 (rank : 1294)	NC score	-0.024434 (rank : 1926)
Query Neighborhood Hits	1762	Target Neighborhood Hits	724	Shared Neighborhood Hits	43
SwissProt Accessions	Q8NBB4, Q6WLH8, Q86WS8	Gene names	ZSCAN1
Domain Architecture	No domain graphic available
Description	Zinc finger and SCAN domain-containing protein 1.

AHTF1_MOUSE
θ value	1.38821 (rank : 1295)	NC score	0.017923 (rank : 1574)
Query Neighborhood Hits	1762	Target Neighborhood Hits	176	Shared Neighborhood Hits	58
SwissProt Accessions	Q8CJF7, Q8BVJ5, Q8VD55	Gene names	Ahctf1, Elys
Domain Architecture	No domain graphic available
Description	AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac).

BAG4_HUMAN
θ value	1.38821 (rank : 1296)	NC score	0.019586 (rank : 1555)
Query Neighborhood Hits	1762	Target Neighborhood Hits	96	Shared Neighborhood Hits	34
SwissProt Accessions	O95429, O95818	Gene names	BAG4, SODD
Domain Architecture
Description	BAG family molecular chaperone regulator 4 (BCL2-associated athanogene 4) (BAG-4) (Silencer of death domains).

BSCL2_HUMAN
θ value	1.38821 (rank : 1297)	NC score	0.011582 (rank : 1663)
Query Neighborhood Hits	1762	Target Neighborhood Hits	148	Shared Neighborhood Hits	31
SwissProt Accessions	Q96G97, Q96SV1, Q9BSQ0	Gene names	BSCL2
Domain Architecture	No domain graphic available
Description	Seipin (Bernardinelli-Seip congenital lipodystrophy type 2 protein).

CBX2_HUMAN
θ value	1.38821 (rank : 1298)	NC score	0.013323 (rank : 1630)
Query Neighborhood Hits	1762	Target Neighborhood Hits	264	Shared Neighborhood Hits	83
SwissProt Accessions	Q14781, Q9BTB1	Gene names	CBX2
Domain Architecture	No domain graphic available
Description	Chromobox protein homolog 2.

CENPT_MOUSE
θ value	1.38821 (rank : 1299)	NC score	0.018306 (rank : 1566)
Query Neighborhood Hits	1762	Target Neighborhood Hits	115	Shared Neighborhood Hits	51
SwissProt Accessions	Q3TJM4, Q3TPY6, Q3UPD2, Q8BTH0, Q8BTP2, Q8R5E9	Gene names	Cenpt
Domain Architecture	No domain graphic available
Description	Centromere protein T (CENP-T).

CF150_HUMAN
θ value	1.38821 (rank : 1300)	NC score	0.029264 (rank : 1459)
Query Neighborhood Hits	1762	Target Neighborhood Hits	96	Shared Neighborhood Hits	37
SwissProt Accessions	Q8N884, Q32NC9, Q5SWL0, Q5SWL1, Q96E45	Gene names	C6orf150
Domain Architecture	No domain graphic available
Description	Protein C6orf150.

CI079_HUMAN
θ value	1.38821 (rank : 1301)	NC score	0.025954 (rank : 1490)
Query Neighborhood Hits	1762	Target Neighborhood Hits	288	Shared Neighborhood Hits	103
SwissProt Accessions	Q6ZUB1, Q5SQC9, Q8NA41, Q8ND27	Gene names	C9orf79
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf79.

CND1_HUMAN
θ value	1.38821 (rank : 1302)	NC score	0.005502 (rank : 1759)
Query Neighborhood Hits	1762	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	Q15021, Q8N6U3	Gene names	NCAPD2, CAPD2, CNAP1, KIAA0159
Domain Architecture
Description	Condensin complex subunit 1 (Non-SMC condensin I complex subunit D2) (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (XCAP-D2 homolog).

DOCK4_HUMAN
θ value	1.38821 (rank : 1303)	NC score	0.007764 (rank : 1718)
Query Neighborhood Hits	1762	Target Neighborhood Hits	237	Shared Neighborhood Hits	82
SwissProt Accessions	Q8N1I0, O14584, O94824, Q8NB45	Gene names	DOCK4, KIAA0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

ECT2_MOUSE
θ value	1.38821 (rank : 1304)	NC score	0.003929 (rank : 1787)
Query Neighborhood Hits	1762	Target Neighborhood Hits	98	Shared Neighborhood Hits	7
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

EFS_HUMAN
θ value	1.38821 (rank : 1305)	NC score	0.043017 (rank : 1355)
Query Neighborhood Hits	1762	Target Neighborhood Hits	348	Shared Neighborhood Hits	137
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

ESAM_MOUSE
θ value	1.38821 (rank : 1306)	NC score	0.176053 (rank : 1024)
Query Neighborhood Hits	1762	Target Neighborhood Hits	222	Shared Neighborhood Hits	166
SwissProt Accessions	Q925F2	Gene names	Esam, Esam1
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

EWS_HUMAN
θ value	1.38821 (rank : 1307)	NC score	0.009127 (rank : 1696)
Query Neighborhood Hits	1762	Target Neighborhood Hits	249	Shared Neighborhood Hits	54
SwissProt Accessions	Q01844, Q92635	Gene names	EWSR1, EWS
Domain Architecture
Description	RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein).

EWS_MOUSE
θ value	1.38821 (rank : 1308)	NC score	0.007284 (rank : 1728)
Query Neighborhood Hits	1762	Target Neighborhood Hits	271	Shared Neighborhood Hits	54
SwissProt Accessions	Q61545	Gene names	Ewsr1, Ews, Ewsh
Domain Architecture
Description	RNA-binding protein EWS.

FMN2_HUMAN
θ value	1.38821 (rank : 1309)	NC score	0.040412 (rank : 1371)
Query Neighborhood Hits	1762	Target Neighborhood Hits	484	Shared Neighborhood Hits	179
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

FOXK1_MOUSE
θ value	1.38821 (rank : 1310)	NC score	-0.001197 (rank : 1857)
Query Neighborhood Hits	1762	Target Neighborhood Hits	215	Shared Neighborhood Hits	59
SwissProt Accessions	P42128, O35939	Gene names	Foxk1, Mnf
Domain Architecture
Description	Forkhead box protein K1 (Myocyte nuclear factor) (MNF).

GLIS3_MOUSE
θ value	1.38821 (rank : 1311)	NC score	-0.021857 (rank : 1921)
Query Neighborhood Hits	1762	Target Neighborhood Hits	861	Shared Neighborhood Hits	90
SwissProt Accessions	Q6XP49, Q8BI60	Gene names	Glis3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS3 (GLI-similar 3).

GTF2I_HUMAN
θ value	1.38821 (rank : 1312)	NC score	0.008028 (rank : 1714)
Query Neighborhood Hits	1762	Target Neighborhood Hits	151	Shared Neighborhood Hits	36
SwissProt Accessions	P78347, O14743, O15359, O43546, O43588, O43589, Q9BSZ4	Gene names	GTF2I, BAP135, WBSCR6
Domain Architecture
Description	General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BTK-associated protein 135) (BAP-135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosome region 6 protein).

HHLA2_HUMAN
θ value	1.38821 (rank : 1313)	NC score	0.094840 (rank : 1132)
Query Neighborhood Hits	1762	Target Neighborhood Hits	140	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UM44, Q9NWQ6	Gene names	HHLA2
Domain Architecture	No domain graphic available
Description	HERV-H LTR-associating protein 2 precursor (Human endogenous retrovirus-H long terminal repeat-associating protein 2).

HMX3_MOUSE
θ value	1.38821 (rank : 1314)	NC score	-0.014389 (rank : 1911)
Query Neighborhood Hits	1762	Target Neighborhood Hits	342	Shared Neighborhood Hits	16
SwissProt Accessions	P42581	Gene names	Hmx3, Nkx-5.1, Nkx5-1
Domain Architecture
Description	Homeobox protein HMX3 (Homeobox protein Nkx-5.1).

HNF3B_MOUSE
θ value	1.38821 (rank : 1315)	NC score	-0.003137 (rank : 1875)
Query Neighborhood Hits	1762	Target Neighborhood Hits	112	Shared Neighborhood Hits	24
SwissProt Accessions	P35583, Q60602	Gene names	Foxa2, Hnf3b, Tcf-3b, Tcf3b
Domain Architecture
Description	Hepatocyte nuclear factor 3-beta (HNF-3B) (Forkhead box protein A2).

IL1R2_HUMAN
θ value	1.38821 (rank : 1316)	NC score	0.179120 (rank : 1020)
Query Neighborhood Hits	1762	Target Neighborhood Hits	153	Shared Neighborhood Hits	123
SwissProt Accessions	P27930, Q9UE68	Gene names	IL1R2, IL1RB
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen) (CDw121b).

INOC1_HUMAN
θ value	1.38821 (rank : 1317)	NC score	0.002417 (rank : 1809)
Query Neighborhood Hits	1762	Target Neighborhood Hits	181	Shared Neighborhood Hits	25
SwissProt Accessions	Q9ULG1, Q9NTG6	Gene names	INOC1, KIAA1259
Domain Architecture	No domain graphic available
Description	Putative DNA helicase INO80 complex homolog 1 (EC 3.6.1.-) (hINO80).

IRAK2_HUMAN
θ value	1.38821 (rank : 1318)	NC score	0.627175 (rank : 764)
Query Neighborhood Hits	1762	Target Neighborhood Hits	714	Shared Neighborhood Hits	678
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

K1688_HUMAN
θ value	1.38821 (rank : 1319)	NC score	0.008733 (rank : 1702)
Query Neighborhood Hits	1762	Target Neighborhood Hits	217	Shared Neighborhood Hits	61
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

KCNQ4_HUMAN
θ value	1.38821 (rank : 1320)	NC score	0.000438 (rank : 1839)
Query Neighborhood Hits	1762	Target Neighborhood Hits	136	Shared Neighborhood Hits	23
SwissProt Accessions	P56696, O96025	Gene names	KCNQ4
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4).

LRRC4_HUMAN
θ value	1.38821 (rank : 1321)	NC score	0.105468 (rank : 1111)
Query Neighborhood Hits	1762	Target Neighborhood Hits	444	Shared Neighborhood Hits	195
SwissProt Accessions	Q9HBW1, Q6ZMI8, Q96A85	Gene names	LRRC4, BAG
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4 precursor (Brain tumor- associated protein LRRC4) (NAG14).

MELPH_HUMAN
θ value	1.38821 (rank : 1322)	NC score	0.008648 (rank : 1703)
Query Neighborhood Hits	1762	Target Neighborhood Hits	145	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BV36, Q9HA71	Gene names	MLPH, SLAC2A
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Synaptotagmin-like protein 2a) (Slp homolog lacking C2 domains a).

MLKL_MOUSE
θ value	1.38821 (rank : 1323)	NC score	0.625091 (rank : 766)
Query Neighborhood Hits	1762	Target Neighborhood Hits	707	Shared Neighborhood Hits	681
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MUC5B_HUMAN
θ value	1.38821 (rank : 1324)	NC score	0.034048 (rank : 1421)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1020	Shared Neighborhood Hits	242
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

NOLC1_HUMAN
θ value	1.38821 (rank : 1325)	NC score	0.053087 (rank : 1298)
Query Neighborhood Hits	1762	Target Neighborhood Hits	452	Shared Neighborhood Hits	137
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

NPAS4_HUMAN
θ value	1.38821 (rank : 1326)	NC score	0.017387 (rank : 1585)
Query Neighborhood Hits	1762	Target Neighborhood Hits	214	Shared Neighborhood Hits	72
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

NRBP_HUMAN
θ value	1.38821 (rank : 1327)	NC score	0.469125 (rank : 822)
Query Neighborhood Hits	1762	Target Neighborhood Hits	448	Shared Neighborhood Hits	419
SwissProt Accessions	Q9UHY1, Q53FZ5, Q96SU3	Gene names	NRBP1, BCON3, NRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein.

PA24B_MOUSE
θ value	1.38821 (rank : 1328)	NC score	0.010745 (rank : 1676)
Query Neighborhood Hits	1762	Target Neighborhood Hits	102	Shared Neighborhood Hits	17
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

PCDH8_HUMAN
θ value	1.38821 (rank : 1329)	NC score	-0.010598 (rank : 1902)
Query Neighborhood Hits	1762	Target Neighborhood Hits	164	Shared Neighborhood Hits	12
SwissProt Accessions	O95206, Q8IYE9, Q96SF1	Gene names	PCDH8
Domain Architecture
Description	Protocadherin-8 precursor (Arcadlin).

PSG6_HUMAN
θ value	1.38821 (rank : 1330)	NC score	0.158098 (rank : 1043)
Query Neighborhood Hits	1762	Target Neighborhood Hits	231	Shared Neighborhood Hits	184
SwissProt Accessions	Q00889	Gene names	PSG6, CGM3, PSGGB
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 6 precursor (PSBG-6).

PTPRU_HUMAN
θ value	1.38821 (rank : 1331)	NC score	0.086514 (rank : 1140)
Query Neighborhood Hits	1762	Target Neighborhood Hits	237	Shared Neighborhood Hits	131
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

RUNX2_HUMAN
θ value	1.38821 (rank : 1332)	NC score	0.012120 (rank : 1653)
Query Neighborhood Hits	1762	Target Neighborhood Hits	103	Shared Neighborhood Hits	39
SwissProt Accessions	Q13950, O14614, O14615, O95181	Gene names	RUNX2, AML3, CBFA1, OSF2, PEBP2A
Domain Architecture
Description	Runt-related transcription factor 2 (Core-binding factor, alpha 1 subunit) (CBF-alpha 1) (Acute myeloid leukemia 3 protein) (Oncogene AML-3) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEBP2-alpha A) (PEA2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) (Osteoblast- specific transcription factor 2) (OSF-2).

RUNX2_MOUSE
θ value	1.38821 (rank : 1333)	NC score	0.011688 (rank : 1661)
Query Neighborhood Hits	1762	Target Neighborhood Hits	119	Shared Neighborhood Hits	44
SwissProt Accessions	Q08775, O35183, Q08776, Q9JLN0, Q9QUQ6, Q9QY29, Q9R0U4, Q9Z2J7	Gene names	Runx2, Aml3, Cbfa1, Osf2, Pebp2a
Domain Architecture
Description	Runt-related transcription factor 2 (Core-binding factor, alpha 1 subunit) (CBF-alpha 1) (Acute myeloid leukemia 3 protein) (Oncogene AML-3) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEBP2-alpha A) (PEA2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) (Osteoblast- specific transcription factor 2) (OSF-2).

SAPS2_MOUSE
θ value	1.38821 (rank : 1334)	NC score	0.007246 (rank : 1731)
Query Neighborhood Hits	1762	Target Neighborhood Hits	47	Shared Neighborhood Hits	15
SwissProt Accessions	Q8R3Q2, Q9CXB7	Gene names	Saps2, Kiaa0685
Domain Architecture
Description	SAPS domain family member 2.

SEN34_MOUSE
θ value	1.38821 (rank : 1335)	NC score	0.014194 (rank : 1620)
Query Neighborhood Hits	1762	Target Neighborhood Hits	158	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BMZ5, Q58EU2, Q99LV6, Q9CYW1	Gene names	Tsen34, Leng5, Sen34
Domain Architecture	No domain graphic available
Description	tRNA-splicing endonuclease subunit Sen34 (EC 3.1.27.9) (tRNA-intron endonuclease Sen34) (Leukocyte receptor cluster member 5 homolog).

SF3B1_HUMAN
θ value	1.38821 (rank : 1336)	NC score	0.031184 (rank : 1441)
Query Neighborhood Hits	1762	Target Neighborhood Hits	341	Shared Neighborhood Hits	118
SwissProt Accessions	O75533	Gene names	SF3B1, SAP155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SF3B1_MOUSE
θ value	1.38821 (rank : 1337)	NC score	0.032021 (rank : 1436)
Query Neighborhood Hits	1762	Target Neighborhood Hits	352	Shared Neighborhood Hits	122
SwissProt Accessions	Q99NB9, Q9CSK5	Gene names	Sf3b1, Sap155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SFRIP_HUMAN
θ value	1.38821 (rank : 1338)	NC score	0.041135 (rank : 1368)
Query Neighborhood Hits	1762	Target Neighborhood Hits	530	Shared Neighborhood Hits	131
SwissProt Accessions	Q99590, Q8IW59	Gene names	SFRS2IP, CASP11, SIP1
Domain Architecture	No domain graphic available
Description	SFRS2-interacting protein (Splicing factor, arginine/serine-rich 2- interacting protein) (SC35-interacting protein 1) (CTD-associated SR protein 11) (Splicing regulatory protein 129) (SRrp129) (NY-REN-40 antigen).

SFRS8_HUMAN
θ value	1.38821 (rank : 1339)	NC score	0.036955 (rank : 1403)
Query Neighborhood Hits	1762	Target Neighborhood Hits	166	Shared Neighborhood Hits	59
SwissProt Accessions	Q12872	Gene names	SFRS8, SWAP
Domain Architecture
Description	Splicing factor, arginine/serine-rich 8 (Suppressor of white apricot protein homolog).

SON_MOUSE
θ value	1.38821 (rank : 1340)	NC score	0.054767 (rank : 1289)
Query Neighborhood Hits	1762	Target Neighborhood Hits	957	Shared Neighborhood Hits	278
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

SORC2_HUMAN
θ value	1.38821 (rank : 1341)	NC score	0.004811 (rank : 1769)
Query Neighborhood Hits	1762	Target Neighborhood Hits	66	Shared Neighborhood Hits	29
SwissProt Accessions	Q96PQ0, Q9P2L7	Gene names	SORCS2, KIAA1329
Domain Architecture
Description	VPS10 domain-containing receptor SorCS2 precursor.

SPRR3_HUMAN
θ value	1.38821 (rank : 1342)	NC score	0.046753 (rank : 1340)
Query Neighborhood Hits	1762	Target Neighborhood Hits	102	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UBC9, O75597, Q4ZGI7, Q5T525, Q8NET7, Q9UDG3	Gene names	SPRR3, SPRC
Domain Architecture
Description	Small proline-rich protein 3 (Cornifin beta) (Esophagin) (22 kDa pancornulin).

SYP2L_MOUSE
θ value	1.38821 (rank : 1343)	NC score	0.026735 (rank : 1482)
Query Neighborhood Hits	1762	Target Neighborhood Hits	289	Shared Neighborhood Hits	114
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

TENX_HUMAN
θ value	1.38821 (rank : 1344)	NC score	0.060260 (rank : 1251)
Query Neighborhood Hits	1762	Target Neighborhood Hits	789	Shared Neighborhood Hits	174
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

UNC5B_MOUSE
θ value	1.38821 (rank : 1345)	NC score	0.109203 (rank : 1105)
Query Neighborhood Hits	1762	Target Neighborhood Hits	226	Shared Neighborhood Hits	139
SwissProt Accessions	Q8K1S3, Q3U4F2, Q6PFH0, Q80Y85, Q9D398	Gene names	Unc5b, Unc5h2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2).

WBS14_MOUSE
θ value	1.38821 (rank : 1346)	NC score	0.026848 (rank : 1480)
Query Neighborhood Hits	1762	Target Neighborhood Hits	171	Shared Neighborhood Hits	78
SwissProt Accessions	Q99MZ3, Q99MY9, Q99MZ0, Q99MZ1, Q99MZ2, Q9JLM5	Gene names	Mlxipl, Mio, Wbscr14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein homolog (Mlx interactor) (MLX-interacting protein-like).

ZN174_HUMAN
θ value	1.38821 (rank : 1347)	NC score	-0.026310 (rank : 1936)
Query Neighborhood Hits	1762	Target Neighborhood Hits	744	Shared Neighborhood Hits	52
SwissProt Accessions	Q15697, Q9BQ34	Gene names	ZNF174, ZSCAN8
Domain Architecture
Description	Zinc finger protein 174 (AW-1) (Zinc finger and SCAN domain-containing protein 8).

ALMS1_HUMAN
θ value	1.81305 (rank : 1348)	NC score	0.022932 (rank : 1518)
Query Neighborhood Hits	1762	Target Neighborhood Hits	356	Shared Neighborhood Hits	104
SwissProt Accessions	Q8TCU4, Q53S05, Q580Q8, Q86VP9, Q9Y4G4	Gene names	ALMS1, KIAA0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1.

AMOT_HUMAN
θ value	1.81305 (rank : 1349)	NC score	0.031831 (rank : 1438)
Query Neighborhood Hits	1762	Target Neighborhood Hits	712	Shared Neighborhood Hits	151
SwissProt Accessions	Q4VCS5, Q504X5, Q9HD27, Q9UPT1	Gene names	AMOT, KIAA1071
Domain Architecture	No domain graphic available
Description	Angiomotin.

ATS14_HUMAN
θ value	1.81305 (rank : 1350)	NC score	0.004878 (rank : 1768)
Query Neighborhood Hits	1762	Target Neighborhood Hits	382	Shared Neighborhood Hits	99
SwissProt Accessions	Q8WXS8, Q8TE55, Q8TEY8	Gene names	ADAMTS14
Domain Architecture
Description	ADAMTS-14 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 14) (ADAM-TS 14) (ADAM-TS14).

ATX7_HUMAN
θ value	1.81305 (rank : 1351)	NC score	0.021867 (rank : 1524)
Query Neighborhood Hits	1762	Target Neighborhood Hits	351	Shared Neighborhood Hits	114
SwissProt Accessions	O15265, O75328, O75329, Q9Y6P8	Gene names	ATXN7, SCA7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein).

BANK1_HUMAN
θ value	1.81305 (rank : 1352)	NC score	0.005609 (rank : 1756)
Query Neighborhood Hits	1762	Target Neighborhood Hits	44	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NDB2, Q8N5K8, Q8NB56, Q8WYN5, Q9NWP2	Gene names	BANK1
Domain Architecture	No domain graphic available
Description	B-cell scaffold protein with ankyrin repeats.

BAZ2A_HUMAN
θ value	1.81305 (rank : 1353)	NC score	0.022375 (rank : 1520)
Query Neighborhood Hits	1762	Target Neighborhood Hits	780	Shared Neighborhood Hits	183
SwissProt Accessions	Q9UIF9, O00536, O15030, Q96H26	Gene names	BAZ2A, KIAA0314, TIP5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3).

BCL6_MOUSE
θ value	1.81305 (rank : 1354)	NC score	-0.026189 (rank : 1935)
Query Neighborhood Hits	1762	Target Neighborhood Hits	913	Shared Neighborhood Hits	83
SwissProt Accessions	P41183, Q61065	Gene names	Bcl6, Bcl-6
Domain Architecture
Description	B-cell lymphoma 6 protein homolog.

CAN12_HUMAN
θ value	1.81305 (rank : 1355)	NC score	-0.000756 (rank : 1849)
Query Neighborhood Hits	1762	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZSI9	Gene names	CAPN12
Domain Architecture	No domain graphic available
Description	Calpain-12 (EC 3.4.22.-).

CK024_HUMAN
θ value	1.81305 (rank : 1356)	NC score	0.054703 (rank : 1290)
Query Neighborhood Hits	1762	Target Neighborhood Hits	408	Shared Neighborhood Hits	182
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

CNTRB_HUMAN
θ value	1.81305 (rank : 1357)	NC score	0.027354 (rank : 1473)
Query Neighborhood Hits	1762	Target Neighborhood Hits	690	Shared Neighborhood Hits	86
SwissProt Accessions	Q8N137, Q331K3, Q69YV7, Q8NCB8, Q8WXV3, Q96CQ7, Q9C060	Gene names	CNTROB, LIP8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

CS016_HUMAN
θ value	1.81305 (rank : 1358)	NC score	0.058641 (rank : 1261)
Query Neighborhood Hits	1762	Target Neighborhood Hits	310	Shared Neighborhood Hits	148
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

ES8L2_HUMAN
θ value	1.81305 (rank : 1359)	NC score	0.030857 (rank : 1444)
Query Neighborhood Hits	1762	Target Neighborhood Hits	193	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

EVC_MOUSE
θ value	1.81305 (rank : 1360)	NC score	0.011844 (rank : 1660)
Query Neighborhood Hits	1762	Target Neighborhood Hits	80	Shared Neighborhood Hits	13
SwissProt Accessions	P57680	Gene names	Evc
Domain Architecture	No domain graphic available
Description	Ellis-van Creveld syndrome protein homolog.

GA2L1_HUMAN
θ value	1.81305 (rank : 1361)	NC score	0.018094 (rank : 1568)
Query Neighborhood Hits	1762	Target Neighborhood Hits	177	Shared Neighborhood Hits	61
SwissProt Accessions	Q99501, Q53EN7, Q92640, Q9BUY9	Gene names	GAS2L1, GAR22
Domain Architecture
Description	GAS2-like protein 1 (Growth arrest-specific 2-like 1) (GAS2-related protein on chromosome 22) (GAR22 protein).

HB2A_MOUSE
θ value	1.81305 (rank : 1362)	NC score	-0.010832 (rank : 1903)
Query Neighborhood Hits	1762	Target Neighborhood Hits	203	Shared Neighborhood Hits	8
SwissProt Accessions	P14483	Gene names	H2-Ab1, H2-iabeta
Domain Architecture
Description	H-2 class II histocompatibility antigen, A beta chain precursor.

HCFC2_HUMAN
θ value	1.81305 (rank : 1363)	NC score	0.067253 (rank : 1218)
Query Neighborhood Hits	1762	Target Neighborhood Hits	154	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y5Z7	Gene names	HCFC2
Domain Architecture	No domain graphic available
Description	Host cell factor 2 (HCF-2) (C2 factor).

JIP2_MOUSE
θ value	1.81305 (rank : 1364)	NC score	0.023732 (rank : 1509)
Query Neighborhood Hits	1762	Target Neighborhood Hits	144	Shared Neighborhood Hits	38
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

MAVS_HUMAN
θ value	1.81305 (rank : 1365)	NC score	0.035800 (rank : 1410)
Query Neighborhood Hits	1762	Target Neighborhood Hits	271	Shared Neighborhood Hits	112
SwissProt Accessions	Q7Z434, Q3I0Y2, Q5T7I6, Q86VY7, Q9H1H3, Q9H4Y1, Q9H8D3, Q9ULE9	Gene names	MAVS, IPS1, KIAA1271, VISA
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif) (Putative NF-kappa-B- activating protein 031N).

MORC2_HUMAN
θ value	1.81305 (rank : 1366)	NC score	0.017728 (rank : 1578)
Query Neighborhood Hits	1762	Target Neighborhood Hits	207	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Y6X9, Q9UF28, Q9Y6V2	Gene names	MORC2, KIAA0852, ZCWCC1
Domain Architecture
Description	MORC family CW-type zinc finger protein 2 (Zinc finger CW-type coiled- coil domain protein 1).

MTR1L_HUMAN
θ value	1.81305 (rank : 1367)	NC score	-0.024010 (rank : 1924)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1180	Shared Neighborhood Hits	112
SwissProt Accessions	Q13585	Gene names	GPR50
Domain Architecture
Description	Melatonin-related receptor (G protein-coupled receptor 50) (H9).

OXRP_HUMAN
θ value	1.81305 (rank : 1368)	NC score	0.001754 (rank : 1821)
Query Neighborhood Hits	1762	Target Neighborhood Hits	544	Shared Neighborhood Hits	106
SwissProt Accessions	Q9Y4L1	Gene names	HYOU1, ORP150
Domain Architecture
Description	150 kDa oxygen-regulated protein precursor (Orp150) (Hypoxia up- regulated 1).

PKHA4_HUMAN
θ value	1.81305 (rank : 1369)	NC score	0.017990 (rank : 1571)
Query Neighborhood Hits	1762	Target Neighborhood Hits	283	Shared Neighborhood Hits	104
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PSG1_HUMAN
θ value	1.81305 (rank : 1370)	NC score	0.161682 (rank : 1039)
Query Neighborhood Hits	1762	Target Neighborhood Hits	232	Shared Neighborhood Hits	190
SwissProt Accessions	P11464, O75236, P11462, P11463, Q15231, Q15241, Q15243, Q16660, Q9P1W5, Q9UQ79	Gene names	PSG1, B1G1, PSGGA
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 1 precursor (PSBG-1) (Pregnancy-specific beta-1 glycoprotein C/D) (PS-beta-C/D) (Fetal liver non-specific cross-reactive antigen 1/2) (FL-NCA-1/2) (PSG95) (CD66f antigen).

PTN23_MOUSE
θ value	1.81305 (rank : 1371)	NC score	0.032330 (rank : 1432)
Query Neighborhood Hits	1762	Target Neighborhood Hits	726	Shared Neighborhood Hits	223
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

RECQ5_HUMAN
θ value	1.81305 (rank : 1372)	NC score	0.007592 (rank : 1721)
Query Neighborhood Hits	1762	Target Neighborhood Hits	390	Shared Neighborhood Hits	113
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

RFX1_HUMAN
θ value	1.81305 (rank : 1373)	NC score	0.029337 (rank : 1456)
Query Neighborhood Hits	1762	Target Neighborhood Hits	256	Shared Neighborhood Hits	132
SwissProt Accessions	P22670	Gene names	RFX1
Domain Architecture
Description	MHC class II regulatory factor RFX1 (RFX) (Enhancer factor C) (EF-C).

RHBD3_HUMAN
θ value	1.81305 (rank : 1374)	NC score	0.006864 (rank : 1735)
Query Neighborhood Hits	1762	Target Neighborhood Hits	15	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y3P4, Q6I9X3, Q9UGQ7	Gene names	RHBDD3, C22orf3
Domain Architecture
Description	Rhomboid domain-containing protein 3.

RTN1_HUMAN
θ value	1.81305 (rank : 1375)	NC score	0.016618 (rank : 1594)
Query Neighborhood Hits	1762	Target Neighborhood Hits	173	Shared Neighborhood Hits	63
SwissProt Accessions	Q16799, Q16800, Q16801	Gene names	RTN1, NSP
Domain Architecture
Description	Reticulon-1 (Neuroendocrine-specific protein).

SDC3_MOUSE
θ value	1.81305 (rank : 1376)	NC score	0.029112 (rank : 1463)
Query Neighborhood Hits	1762	Target Neighborhood Hits	107	Shared Neighborhood Hits	55
SwissProt Accessions	Q64519, Q3UDD9, Q6ZQA4, Q7TQD4	Gene names	Sdc3, Kiaa0468
Domain Architecture
Description	Syndecan-3 precursor (SYND3).

SEM6D_HUMAN
θ value	1.81305 (rank : 1377)	NC score	0.000419 (rank : 1840)
Query Neighborhood Hits	1762	Target Neighborhood Hits	169	Shared Neighborhood Hits	38
SwissProt Accessions	Q8NFY4, Q8NFY3, Q8NFY5, Q8NFY6, Q8NFY7, Q9P249	Gene names	SEMA6D, KIAA1479
Domain Architecture	No domain graphic available
Description	Semaphorin-6D precursor.

SPHK2_MOUSE
θ value	1.81305 (rank : 1378)	NC score	0.006338 (rank : 1741)
Query Neighborhood Hits	1762	Target Neighborhood Hits	78	Shared Neighborhood Hits	27
SwissProt Accessions	Q9JIA7, Q91VA9, Q9DBH6	Gene names	Sphk2
Domain Architecture
Description	Sphingosine kinase 2 (EC 2.7.1.-) (SK 2) (SPK 2).

TAB3_MOUSE
θ value	1.81305 (rank : 1379)	NC score	0.015828 (rank : 1603)
Query Neighborhood Hits	1762	Target Neighborhood Hits	273	Shared Neighborhood Hits	92
SwissProt Accessions	Q571K4	Gene names	Map3k7ip3, Kiaa4135, Tab3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3).

TAF4_HUMAN
θ value	1.81305 (rank : 1380)	NC score	0.069310 (rank : 1207)
Query Neighborhood Hits	1762	Target Neighborhood Hits	687	Shared Neighborhood Hits	239
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

TCP10_HUMAN
θ value	1.81305 (rank : 1381)	NC score	0.021858 (rank : 1525)
Query Neighborhood Hits	1762	Target Neighborhood Hits	134	Shared Neighborhood Hits	49
SwissProt Accessions	Q12799	Gene names	TCP10, TCP10A
Domain Architecture
Description	T-complex protein 10A homolog.

TMUB1_HUMAN
θ value	1.81305 (rank : 1382)	NC score	0.008177 (rank : 1711)
Query Neighborhood Hits	1762	Target Neighborhood Hits	30	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BVT8	Gene names	TMUB1, C7orf21
Domain Architecture
Description	Transmembrane and ubiquitin-like domain-containing protein 1 (Ubiquitin-like protein SB144).

TPO_MOUSE
θ value	1.81305 (rank : 1383)	NC score	0.016085 (rank : 1601)
Query Neighborhood Hits	1762	Target Neighborhood Hits	258	Shared Neighborhood Hits	70
SwissProt Accessions	P40226	Gene names	Thpo
Domain Architecture
Description	Thrombopoietin precursor (Megakaryocyte colony-stimulating factor) (Myeloproliferative leukemia virus oncogene ligand) (C-mpl ligand) (ML) (Megakaryocyte growth and development factor) (MGDF).

UNC5C_MOUSE
θ value	1.81305 (rank : 1384)	NC score	0.118119 (rank : 1093)
Query Neighborhood Hits	1762	Target Neighborhood Hits	225	Shared Neighborhood Hits	143
SwissProt Accessions	O08747, Q8CD16	Gene names	Unc5c, Rcm, Unc5h3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3) (Rostral cerebellar malformation protein).

USH1C_MOUSE
θ value	1.81305 (rank : 1385)	NC score	0.011271 (rank : 1669)
Query Neighborhood Hits	1762	Target Neighborhood Hits	557	Shared Neighborhood Hits	92
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

YAP1_HUMAN
θ value	1.81305 (rank : 1386)	NC score	0.011429 (rank : 1667)
Query Neighborhood Hits	1762	Target Neighborhood Hits	173	Shared Neighborhood Hits	56
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

ZAR1_MOUSE
θ value	1.81305 (rank : 1387)	NC score	0.025204 (rank : 1495)
Query Neighborhood Hits	1762	Target Neighborhood Hits	254	Shared Neighborhood Hits	88
SwissProt Accessions	Q80SU3	Gene names	Zar1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

ZO1_MOUSE
θ value	1.81305 (rank : 1388)	NC score	0.013489 (rank : 1626)
Query Neighborhood Hits	1762	Target Neighborhood Hits	453	Shared Neighborhood Hits	129
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ALEX_HUMAN
θ value	2.36792 (rank : 1389)	NC score	0.061012 (rank : 1245)
Query Neighborhood Hits	1762	Target Neighborhood Hits	361	Shared Neighborhood Hits	160
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

AT11C_HUMAN
θ value	2.36792 (rank : 1390)	NC score	-0.003718 (rank : 1882)
Query Neighborhood Hits	1762	Target Neighborhood Hits	89	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NB49, Q5JT69, Q5JT70, Q5JT71, Q5JT72, Q5JT73, Q6ZND5, Q6ZU50, Q6ZUP7, Q70IJ9, Q70IK0, Q8WX24	Gene names	ATP11C, ATPIG, ATPIQ
Domain Architecture	No domain graphic available
Description	Probable phospholipid-transporting ATPase IG (EC 3.6.3.1) (ATPase class I type 11C) (ATPase IG) (ATPase IQ) (ATPase class VI type 11C).

ATS19_HUMAN
θ value	2.36792 (rank : 1391)	NC score	0.003317 (rank : 1799)
Query Neighborhood Hits	1762	Target Neighborhood Hits	203	Shared Neighborhood Hits	51
SwissProt Accessions	Q8TE59	Gene names	ADAMTS19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

ATX7_MOUSE
θ value	2.36792 (rank : 1392)	NC score	0.021825 (rank : 1526)
Query Neighborhood Hits	1762	Target Neighborhood Hits	328	Shared Neighborhood Hits	122
SwissProt Accessions	Q8R4I1, Q8BL17	Gene names	Atxn7, Sca7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein homolog).

BAZ2A_MOUSE
θ value	2.36792 (rank : 1393)	NC score	0.025256 (rank : 1494)
Query Neighborhood Hits	1762	Target Neighborhood Hits	744	Shared Neighborhood Hits	208
SwissProt Accessions	Q91YE5	Gene names	Baz2a, Tip5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5).

BIN1_MOUSE
θ value	2.36792 (rank : 1394)	NC score	0.015633 (rank : 1606)
Query Neighborhood Hits	1762	Target Neighborhood Hits	283	Shared Neighborhood Hits	81
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

CABL1_MOUSE
θ value	2.36792 (rank : 1395)	NC score	0.004000 (rank : 1785)
Query Neighborhood Hits	1762	Target Neighborhood Hits	31	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ESJ1, Q9EPR8	Gene names	Cables1, Cables
Domain Architecture	No domain graphic available
Description	CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1).

CAN12_MOUSE
θ value	2.36792 (rank : 1396)	NC score	-0.001378 (rank : 1863)
Query Neighborhood Hits	1762	Target Neighborhood Hits	56	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ER56, Q9ER53, Q9ER54, Q9ER55	Gene names	Capn12
Domain Architecture
Description	Calpain-12 (EC 3.4.22.-).

CD166_HUMAN
θ value	2.36792 (rank : 1397)	NC score	0.207455 (rank : 1007)
Query Neighborhood Hits	1762	Target Neighborhood Hits	247	Shared Neighborhood Hits	178
SwissProt Accessions	Q13740, O60892	Gene names	ALCAM, MEMD
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM).

CGRE1_HUMAN
θ value	2.36792 (rank : 1398)	NC score	0.018059 (rank : 1570)
Query Neighborhood Hits	1762	Target Neighborhood Hits	354	Shared Neighborhood Hits	98
SwissProt Accessions	Q99674	Gene names	CGREF1, CGR11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

CMTA1_HUMAN
θ value	2.36792 (rank : 1399)	NC score	0.007197 (rank : 1732)
Query Neighborhood Hits	1762	Target Neighborhood Hits	217	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y6Y1, Q5VUE1	Gene names	CAMTA1, KIAA0833
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 1.

CO002_HUMAN
θ value	2.36792 (rank : 1400)	NC score	0.034644 (rank : 1415)
Query Neighborhood Hits	1762	Target Neighborhood Hits	387	Shared Neighborhood Hits	129
SwissProt Accessions	Q9NZP6	Gene names	C15orf2
Domain Architecture	No domain graphic available
Description	Protein C15orf2.

CTDP1_HUMAN
θ value	2.36792 (rank : 1401)	NC score	0.031321 (rank : 1440)
Query Neighborhood Hits	1762	Target Neighborhood Hits	416	Shared Neighborhood Hits	146
SwissProt Accessions	Q9Y5B0, Q7Z644, Q96BZ1, Q9Y6F5	Gene names	CTDP1, FCP1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

CUTL1_MOUSE
θ value	2.36792 (rank : 1402)	NC score	0.016798 (rank : 1593)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1620	Shared Neighborhood Hits	217
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

DEN1A_HUMAN
θ value	2.36792 (rank : 1403)	NC score	0.009010 (rank : 1698)
Query Neighborhood Hits	1762	Target Neighborhood Hits	176	Shared Neighborhood Hits	66
SwissProt Accessions	Q8TEH3, Q5VWF0, Q8IVD6, Q9H796	Gene names	DENND1A
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 1A.

DNM3B_MOUSE
θ value	2.36792 (rank : 1404)	NC score	0.004303 (rank : 1778)
Query Neighborhood Hits	1762	Target Neighborhood Hits	61	Shared Neighborhood Hits	6
SwissProt Accessions	O88509, O88510, O88511	Gene names	Dnmt3b
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3B (EC 2.1.1.37) (Dnmt3b) (DNA methyltransferase MmuIIIB) (DNA MTase MmuIIIB) (M.MmuIIIB).

FNDC3_HUMAN
θ value	2.36792 (rank : 1405)	NC score	0.231107 (rank : 1000)
Query Neighborhood Hits	1762	Target Neighborhood Hits	196	Shared Neighborhood Hits	131
SwissProt Accessions	Q9Y2H6, Q5JVF9, Q6EVH3, Q6N020, Q6P9D5, Q9H1W1	Gene names	FNDC3A, FNDC3, KIAA0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

FNDC3_MOUSE
θ value	2.36792 (rank : 1406)	NC score	0.232014 (rank : 998)
Query Neighborhood Hits	1762	Target Neighborhood Hits	207	Shared Neighborhood Hits	131
SwissProt Accessions	Q8BX90, Q2VEY7, Q6ZQ15, Q811D3, Q8BTM3	Gene names	Fndc3a, D14Ertd453e, Fndc3, Kiaa0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

FOXP4_MOUSE
θ value	2.36792 (rank : 1407)	NC score	-0.002906 (rank : 1873)
Query Neighborhood Hits	1762	Target Neighborhood Hits	211	Shared Neighborhood Hits	37
SwissProt Accessions	Q9DBY0, Q80V92, Q8CG10, Q8CIS1	Gene names	Foxp4
Domain Architecture	No domain graphic available
Description	Forkhead box protein P4 (Fork head-related protein like A) (mFKHLA).

FYB_MOUSE
θ value	2.36792 (rank : 1408)	NC score	0.029299 (rank : 1457)
Query Neighborhood Hits	1762	Target Neighborhood Hits	194	Shared Neighborhood Hits	65
SwissProt Accessions	O35601, Q9Z2H3	Gene names	Fyb
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

GON2_HUMAN
θ value	2.36792 (rank : 1409)	NC score	0.011511 (rank : 1664)
Query Neighborhood Hits	1762	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	O43555, Q9BYN9, Q9BYP0	Gene names	GNRH2
Domain Architecture	No domain graphic available
Description	Progonadoliberin-2 precursor (Progonadoliberin II) [Contains: Gonadoliberin-2 (Gonadoliberin II) (Luteinizing hormone-releasing hormone II) (LH-RH II) (Gonadotropin-releasing hormone II) (GnRH II) (Luliberin II); GnRH-associated peptide 2 (GnRH-associated peptide II)].

GPA33_HUMAN
θ value	2.36792 (rank : 1410)	NC score	0.204818 (rank : 1008)
Query Neighborhood Hits	1762	Target Neighborhood Hits	273	Shared Neighborhood Hits	175
SwissProt Accessions	Q99795	Gene names	GPA33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33).

GPR37_HUMAN
θ value	2.36792 (rank : 1411)	NC score	-0.019841 (rank : 1917)
Query Neighborhood Hits	1762	Target Neighborhood Hits	584	Shared Neighborhood Hits	14
SwissProt Accessions	O15354, O00348, O14768, Q8TD39	Gene names	GPR37
Domain Architecture
Description	Probable G-protein coupled receptor 37 precursor (Endothelin B receptor-like protein 1) (ETBR-LP-1) (Parkin-associated endothelin receptor-like receptor) (PAELR).

GPS2_HUMAN
θ value	2.36792 (rank : 1412)	NC score	0.030993 (rank : 1442)
Query Neighborhood Hits	1762	Target Neighborhood Hits	459	Shared Neighborhood Hits	96
SwissProt Accessions	Q13227	Gene names	GPS2
Domain Architecture	No domain graphic available
Description	G protein pathway suppressor 2 (Protein GPS2).

GRASP_HUMAN
θ value	2.36792 (rank : 1413)	NC score	0.017941 (rank : 1573)
Query Neighborhood Hits	1762	Target Neighborhood Hits	147	Shared Neighborhood Hits	30
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

HXB3_HUMAN
θ value	2.36792 (rank : 1414)	NC score	-0.013234 (rank : 1909)
Query Neighborhood Hits	1762	Target Neighborhood Hits	559	Shared Neighborhood Hits	82
SwissProt Accessions	P14651, O95615, P17484	Gene names	HOXB3, HOX2G
Domain Architecture
Description	Homeobox protein Hox-B3 (Hox-2G) (Hox-2.7).

I11RA_HUMAN
θ value	2.36792 (rank : 1415)	NC score	0.045559 (rank : 1343)
Query Neighborhood Hits	1762	Target Neighborhood Hits	138	Shared Neighborhood Hits	56
SwissProt Accessions	Q14626, Q16542, Q7KYJ7	Gene names	IL11RA
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha chain precursor (IL-11R-alpha) (IL- 11RA).

INOC1_MOUSE
θ value	2.36792 (rank : 1416)	NC score	0.001152 (rank : 1830)
Query Neighborhood Hits	1762	Target Neighborhood Hits	178	Shared Neighborhood Hits	25
SwissProt Accessions	Q6ZPV2, Q6P7V0, Q6PCP1, Q8C9T7	Gene names	Inoc1, Kiaa1259
Domain Architecture	No domain graphic available
Description	Putative DNA helicase INO80 complex homolog 1 (EC 3.6.1.-).

JIP1_MOUSE
θ value	2.36792 (rank : 1417)	NC score	0.020433 (rank : 1542)
Query Neighborhood Hits	1762	Target Neighborhood Hits	259	Shared Neighborhood Hits	88
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP3_HUMAN
θ value	2.36792 (rank : 1418)	NC score	0.024605 (rank : 1501)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1039	Shared Neighborhood Hits	202
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

KIF17_MOUSE
θ value	2.36792 (rank : 1419)	NC score	-0.002709 (rank : 1870)
Query Neighborhood Hits	1762	Target Neighborhood Hits	452	Shared Neighborhood Hits	51
SwissProt Accessions	Q99PW8	Gene names	Kif17
Domain Architecture
Description	Kinesin-like protein KIF17 (MmKIF17).

LRRF1_HUMAN
θ value	2.36792 (rank : 1420)	NC score	0.015152 (rank : 1611)
Query Neighborhood Hits	1762	Target Neighborhood Hits	625	Shared Neighborhood Hits	75
SwissProt Accessions	Q32MZ4, O75766, O75799, Q32MZ5, Q53T49, Q6PKG2	Gene names	LRRFIP1, GCF2, TRIP
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII- interacting protein 1) (TAR RNA-interacting protein) (GC-binding factor 2).

MARCS_MOUSE
θ value	2.36792 (rank : 1421)	NC score	0.055476 (rank : 1283)
Query Neighborhood Hits	1762	Target Neighborhood Hits	227	Shared Neighborhood Hits	103
SwissProt Accessions	P26645	Gene names	Marcks, Macs
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS).

MYCB2_MOUSE
θ value	2.36792 (rank : 1422)	NC score	0.019006 (rank : 1560)
Query Neighborhood Hits	1762	Target Neighborhood Hits	307	Shared Neighborhood Hits	69
SwissProt Accessions	Q7TPH6, Q6PCM8	Gene names	Mycbp2, Pam, Phr1
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

NOTC2_MOUSE
θ value	2.36792 (rank : 1423)	NC score	0.002778 (rank : 1804)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1069	Shared Neighborhood Hits	143
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

NPAS4_MOUSE
θ value	2.36792 (rank : 1424)	NC score	0.020960 (rank : 1534)
Query Neighborhood Hits	1762	Target Neighborhood Hits	245	Shared Neighborhood Hits	96
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

PAF49_HUMAN
θ value	2.36792 (rank : 1425)	NC score	0.027971 (rank : 1469)
Query Neighborhood Hits	1762	Target Neighborhood Hits	169	Shared Neighborhood Hits	68
SwissProt Accessions	O15446, Q32N11, Q7Z5U2, Q9UPF6	Gene names	CD3EAP, ASE1, CAST, PAF49
Domain Architecture	No domain graphic available
Description	RNA polymerase I-associated factor PAF49 (Anti-sense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (CAST).

PER3_HUMAN
θ value	2.36792 (rank : 1426)	NC score	0.019722 (rank : 1554)
Query Neighborhood Hits	1762	Target Neighborhood Hits	479	Shared Neighborhood Hits	161
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

PERQ1_MOUSE
θ value	2.36792 (rank : 1427)	NC score	0.020945 (rank : 1535)
Query Neighborhood Hits	1762	Target Neighborhood Hits	215	Shared Neighborhood Hits	47
SwissProt Accessions	Q99MR1	Gene names	Perq1
Domain Architecture
Description	PERQ amino acid rich with GYF domain protein 1.

PGFRL_MOUSE
θ value	2.36792 (rank : 1428)	NC score	0.135592 (rank : 1070)
Query Neighborhood Hits	1762	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	Q6PE55, Q3V182, Q9D0Z1	Gene names	Pdgfrl
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor.

PO6F1_MOUSE
θ value	2.36792 (rank : 1429)	NC score	0.004743 (rank : 1773)
Query Neighborhood Hits	1762	Target Neighborhood Hits	581	Shared Neighborhood Hits	114
SwissProt Accessions	Q07916, Q91XK3	Gene names	Pou6f1, Emb
Domain Architecture
Description	POU domain, class 6, transcription factor 1 (Octamer-binding transcription factor EMB) (Transcription regulatory protein MCP-1).

PSG11_HUMAN
θ value	2.36792 (rank : 1430)	NC score	0.163476 (rank : 1036)
Query Neighborhood Hits	1762	Target Neighborhood Hits	223	Shared Neighborhood Hits	186
SwissProt Accessions	Q9UQ72, Q13179, Q15242, Q9UNE4	Gene names	PSG11, PSG13
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 11 precursor (PSBG-11) (PSBG- 13).

PSG7_HUMAN
θ value	2.36792 (rank : 1431)	NC score	0.164687 (rank : 1034)
Query Neighborhood Hits	1762	Target Neighborhood Hits	239	Shared Neighborhood Hits	190
SwissProt Accessions	Q13046, Q15232	Gene names	PSG7
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 7 precursor (PSBG-7).

RFFL_HUMAN
θ value	2.36792 (rank : 1432)	NC score	-0.001918 (rank : 1866)
Query Neighborhood Hits	1762	Target Neighborhood Hits	175	Shared Neighborhood Hits	13
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

RTN1_MOUSE
θ value	2.36792 (rank : 1433)	NC score	0.025012 (rank : 1497)
Query Neighborhood Hits	1762	Target Neighborhood Hits	189	Shared Neighborhood Hits	78
SwissProt Accessions	Q8K0T0, Q8K4S4	Gene names	Rtn1, Nsp
Domain Architecture	No domain graphic available
Description	Reticulon-1 (Neuroendocrine-specific protein).

S27A4_MOUSE
θ value	2.36792 (rank : 1434)	NC score	-0.001499 (rank : 1864)
Query Neighborhood Hits	1762	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q91VE0, O88562	Gene names	Slc27a4, Acsvl4, Fatp4
Domain Architecture	No domain graphic available
Description	Long-chain fatty acid transport protein 4 (EC 6.2.1.-) (Fatty acid transport protein 4) (FATP-4) (Solute carrier family 27 member 4).

SAHH3_MOUSE
θ value	2.36792 (rank : 1435)	NC score	0.007272 (rank : 1729)
Query Neighborhood Hits	1762	Target Neighborhood Hits	35	Shared Neighborhood Hits	16
SwissProt Accessions	Q68FL4, Q8BIH1	Gene names
Domain Architecture	No domain graphic available
Description	Putative adenosylhomocysteinase 3 (EC 3.3.1.1) (S-adenosyl-L- homocysteine hydrolase 3) (AdoHcyase 3).

SEM3B_HUMAN
θ value	2.36792 (rank : 1436)	NC score	-0.000261 (rank : 1847)
Query Neighborhood Hits	1762	Target Neighborhood Hits	76	Shared Neighborhood Hits	18
SwissProt Accessions	Q13214, Q8TB71, Q8TDV7, Q93018, Q96GX0	Gene names	SEMA3B, SEMA5
Domain Architecture
Description	Semaphorin-3B precursor (Semaphorin V) (Sema V) (Sema A(V)).

TAF9_MOUSE
θ value	2.36792 (rank : 1437)	NC score	0.005446 (rank : 1760)
Query Neighborhood Hits	1762	Target Neighborhood Hits	69	Shared Neighborhood Hits	23
SwissProt Accessions	Q8VI33, Q32P09, Q80XS3, Q9CV61	Gene names	Taf9, Taf2g
Domain Architecture
Description	Transcription initiation factor TFIID subunit 9 (Transcription initiation factor TFIID 31 kDa subunit) (TAFII-31) (TAFII-32) (TAFII32).

TAU_HUMAN
θ value	2.36792 (rank : 1438)	NC score	0.043907 (rank : 1349)
Query Neighborhood Hits	1762	Target Neighborhood Hits	448	Shared Neighborhood Hits	172
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

TBCD2_HUMAN
θ value	2.36792 (rank : 1439)	NC score	0.004616 (rank : 1776)
Query Neighborhood Hits	1762	Target Neighborhood Hits	419	Shared Neighborhood Hits	69
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

TENS4_MOUSE
θ value	2.36792 (rank : 1440)	NC score	0.038896 (rank : 1384)
Query Neighborhood Hits	1762	Target Neighborhood Hits	225	Shared Neighborhood Hits	96
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

TTLL4_HUMAN
θ value	2.36792 (rank : 1441)	NC score	0.000939 (rank : 1834)
Query Neighborhood Hits	1762	Target Neighborhood Hits	79	Shared Neighborhood Hits	19
SwissProt Accessions	Q14679, Q8WW29	Gene names	TTLL4, KIAA0173
Domain Architecture
Description	Tubulin--tyrosine ligase-like protein 4.

YLPM1_HUMAN
θ value	2.36792 (rank : 1442)	NC score	0.053249 (rank : 1297)
Query Neighborhood Hits	1762	Target Neighborhood Hits	670	Shared Neighborhood Hits	250
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

ZIMP7_HUMAN
θ value	2.36792 (rank : 1443)	NC score	0.012433 (rank : 1647)
Query Neighborhood Hits	1762	Target Neighborhood Hits	290	Shared Neighborhood Hits	84
SwissProt Accessions	Q8NF64, O94790, Q659A8, Q6JKL5, Q8WTX8, Q96Q01, Q9BQH7	Gene names	ZIMP7, KIAA1886
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

ZIMP7_MOUSE
θ value	2.36792 (rank : 1444)	NC score	0.012399 (rank : 1648)
Query Neighborhood Hits	1762	Target Neighborhood Hits	566	Shared Neighborhood Hits	166
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

ZMYM3_HUMAN
θ value	2.36792 (rank : 1445)	NC score	0.012054 (rank : 1654)
Query Neighborhood Hits	1762	Target Neighborhood Hits	223	Shared Neighborhood Hits	67
SwissProt Accessions	Q14202, O15089	Gene names	ZMYM3, DXS6673E, KIAA0385, ZNF261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261).

ZO2_MOUSE
θ value	2.36792 (rank : 1446)	NC score	0.010451 (rank : 1681)
Query Neighborhood Hits	1762	Target Neighborhood Hits	296	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ACV1C_MOUSE
θ value	3.0926 (rank : 1447)	NC score	0.546311 (rank : 806)
Query Neighborhood Hits	1762	Target Neighborhood Hits	715	Shared Neighborhood Hits	690
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

BAT2_MOUSE
θ value	3.0926 (rank : 1448)	NC score	0.058007 (rank : 1270)
Query Neighborhood Hits	1762	Target Neighborhood Hits	947	Shared Neighborhood Hits	338
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

BOLL_HUMAN
θ value	3.0926 (rank : 1449)	NC score	-0.007948 (rank : 1897)
Query Neighborhood Hits	1762	Target Neighborhood Hits	227	Shared Neighborhood Hits	18
SwissProt Accessions	Q8N9W6, Q969U3	Gene names	BOLL, BOULE
Domain Architecture
Description	Protein boule-like.

CEP68_HUMAN
θ value	3.0926 (rank : 1450)	NC score	0.012609 (rank : 1641)
Query Neighborhood Hits	1762	Target Neighborhood Hits	128	Shared Neighborhood Hits	50
SwissProt Accessions	Q76N32, O60326, Q9BQ18, Q9UDM9	Gene names	CEP68, KIAA0582
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 68 kDa (Cep68 protein).

CJ012_HUMAN
θ value	3.0926 (rank : 1451)	NC score	0.041960 (rank : 1363)
Query Neighborhood Hits	1762	Target Neighborhood Hits	467	Shared Neighborhood Hits	126
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

CO5A1_HUMAN
θ value	3.0926 (rank : 1452)	NC score	0.007262 (rank : 1730)
Query Neighborhood Hits	1762	Target Neighborhood Hits	434	Shared Neighborhood Hits	145
SwissProt Accessions	P20908, Q15094, Q5SUX4	Gene names	COL5A1
Domain Architecture
Description	Collagen alpha-1(V) chain precursor.

CTND2_HUMAN
θ value	3.0926 (rank : 1453)	NC score	0.013693 (rank : 1624)
Query Neighborhood Hits	1762	Target Neighborhood Hits	333	Shared Neighborhood Hits	115
SwissProt Accessions	Q9UQB3, O00379, O15390, O43206, O43840, Q13589, Q9UM66, Q9UPM3	Gene names	CTNND2, NPRAP
Domain Architecture
Description	Catenin delta-2 (Delta-catenin) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) (GT24).

DBPA_HUMAN
θ value	3.0926 (rank : 1454)	NC score	0.009675 (rank : 1687)
Query Neighborhood Hits	1762	Target Neighborhood Hits	52	Shared Neighborhood Hits	19
SwissProt Accessions	P16989, Q14121, Q969N6	Gene names	CSDA, DBPA
Domain Architecture
Description	DNA-binding protein A (Cold shock domain-containing protein A) (Single-strand DNA-binding protein NF-GMB).

DBP_HUMAN
θ value	3.0926 (rank : 1455)	NC score	0.009276 (rank : 1692)
Query Neighborhood Hits	1762	Target Neighborhood Hits	136	Shared Neighborhood Hits	47
SwissProt Accessions	Q10586	Gene names	DBP
Domain Architecture
Description	D site-binding protein (Albumin D box-binding protein) (Albumin D- element-binding protein) (TAXREB302).

DOT1L_HUMAN
θ value	3.0926 (rank : 1456)	NC score	0.040214 (rank : 1373)
Query Neighborhood Hits	1762	Target Neighborhood Hits	660	Shared Neighborhood Hits	198
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

DSPP_MOUSE
θ value	3.0926 (rank : 1457)	NC score	0.020546 (rank : 1541)
Query Neighborhood Hits	1762	Target Neighborhood Hits	491	Shared Neighborhood Hits	80
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

FGFP2_HUMAN
θ value	3.0926 (rank : 1458)	NC score	0.006698 (rank : 1738)
Query Neighborhood Hits	1762	Target Neighborhood Hits	12	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BYJ0	Gene names	FGFBP2, KSP37
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor-binding protein 2 precursor (FGF-binding protein 2) (FGF-BP2) (FGFBP-2) (37 kDa killer-specific secretory protein) (Ksp37) (HBp17-related protein) (HBp17-RP).

FOG1_MOUSE
θ value	3.0926 (rank : 1459)	NC score	-0.008083 (rank : 1898)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1237	Shared Neighborhood Hits	247
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

FOXP4_HUMAN
θ value	3.0926 (rank : 1460)	NC score	-0.003062 (rank : 1874)
Query Neighborhood Hits	1762	Target Neighborhood Hits	246	Shared Neighborhood Hits	53
SwissProt Accessions	Q8IVH2, Q96E19	Gene names	FOXP4, FKHLA
Domain Architecture
Description	Forkhead box protein P4 (Fork head-related protein-like A).

GOGA3_HUMAN
θ value	3.0926 (rank : 1461)	NC score	0.011934 (rank : 1658)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1317	Shared Neighborhood Hits	140
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

GUC2C_HUMAN
θ value	3.0926 (rank : 1462)	NC score	0.459439 (rank : 826)
Query Neighborhood Hits	1762	Target Neighborhood Hits	624	Shared Neighborhood Hits	571
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

HAIR_MOUSE
θ value	3.0926 (rank : 1463)	NC score	0.003674 (rank : 1790)
Query Neighborhood Hits	1762	Target Neighborhood Hits	97	Shared Neighborhood Hits	23
SwissProt Accessions	Q61645, Q80Y47	Gene names	Hr
Domain Architecture
Description	Protein hairless.

HTF4_MOUSE
θ value	3.0926 (rank : 1464)	NC score	-0.000149 (rank : 1845)
Query Neighborhood Hits	1762	Target Neighborhood Hits	153	Shared Neighborhood Hits	23
SwissProt Accessions	Q61286	Gene names	Tcf12, Alf1, Meb
Domain Architecture
Description	Transcription factor 12 (Transcription factor HTF-4) (E-box-binding protein) (DNA-binding protein HTF4) (Class A helix-loop-helix transcription factor ME1).

IGSF8_HUMAN
θ value	3.0926 (rank : 1465)	NC score	0.043543 (rank : 1351)
Query Neighborhood Hits	1762	Target Neighborhood Hits	88	Shared Neighborhood Hits	40
SwissProt Accessions	Q969P0, Q8NG09, Q96DP4, Q9BTG9	Gene names	IGSF8, CD81P3, EWI2, KCT4
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 8 precursor (CD81 partner 3) (Glu- Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes- associated transmembrane protein 4) (KCT-4) (LIR-D1) (CD316 antigen).

IRAK1_MOUSE
θ value	3.0926 (rank : 1466)	NC score	0.681658 (rank : 665)
Query Neighborhood Hits	1762	Target Neighborhood Hits	784	Shared Neighborhood Hits	740
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

JHD2A_HUMAN
θ value	3.0926 (rank : 1467)	NC score	0.003485 (rank : 1796)
Query Neighborhood Hits	1762	Target Neighborhood Hits	118	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y4C1, Q53S72, Q68D47, Q68UT9, Q6N050, Q8IY08	Gene names	JMJD1A, JHDM2A, JMJD1, KIAA0742
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2A (EC 1.14.11.-) (Jumonji domain-containing protein 1A).

JHD3B_MOUSE
θ value	3.0926 (rank : 1468)	NC score	0.007654 (rank : 1720)
Query Neighborhood Hits	1762	Target Neighborhood Hits	152	Shared Neighborhood Hits	61
SwissProt Accessions	Q91VY5, Q3UR22, Q6ZQ30, Q99K42	Gene names	Jmjd2b, Jhdm3b
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3B (EC 1.14.11.-) (Jumonji domain-containing protein 2B).

K1543_MOUSE
θ value	3.0926 (rank : 1469)	NC score	0.038689 (rank : 1386)
Query Neighborhood Hits	1762	Target Neighborhood Hits	497	Shared Neighborhood Hits	170
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

K2027_HUMAN
θ value	3.0926 (rank : 1470)	NC score	0.026903 (rank : 1477)
Query Neighborhood Hits	1762	Target Neighborhood Hits	194	Shared Neighborhood Hits	69
SwissProt Accessions	Q6ZVF9, Q8IVE4	Gene names	KIAA2027
Domain Architecture	No domain graphic available
Description	Protein KIAA2027.

KCNC3_HUMAN
θ value	3.0926 (rank : 1471)	NC score	-0.001262 (rank : 1860)
Query Neighborhood Hits	1762	Target Neighborhood Hits	256	Shared Neighborhood Hits	73
SwissProt Accessions	Q14003	Gene names	KCNC3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

MEN1_MOUSE
θ value	3.0926 (rank : 1472)	NC score	0.007765 (rank : 1717)
Query Neighborhood Hits	1762	Target Neighborhood Hits	31	Shared Neighborhood Hits	14
SwissProt Accessions	O88559	Gene names	Men1
Domain Architecture
Description	Menin.

MUC2_HUMAN
θ value	3.0926 (rank : 1473)	NC score	0.048233 (rank : 1330)
Query Neighborhood Hits	1762	Target Neighborhood Hits	906	Shared Neighborhood Hits	277
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

NTBP1_MOUSE
θ value	3.0926 (rank : 1474)	NC score	0.018923 (rank : 1562)
Query Neighborhood Hits	1762	Target Neighborhood Hits	528	Shared Neighborhood Hits	91
SwissProt Accessions	Q8BRM2, Q8CAA8	Gene names	Scyl1bp1, Ntklbp1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like-binding protein 1 (NTKL-binding protein 1) (NTKL-BP1) (mNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-binding protein 1) (SCYL1-BP1).

PCBP4_HUMAN
θ value	3.0926 (rank : 1475)	NC score	0.001924 (rank : 1817)
Query Neighborhood Hits	1762	Target Neighborhood Hits	49	Shared Neighborhood Hits	12
SwissProt Accessions	P57723, Q96AH7	Gene names	PCBP4
Domain Architecture
Description	Poly(rC)-binding protein 4 (Alpha-CP4).

PININ_HUMAN
θ value	3.0926 (rank : 1476)	NC score	0.036436 (rank : 1405)
Query Neighborhood Hits	1762	Target Neighborhood Hits	753	Shared Neighborhood Hits	116
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

PLCB3_HUMAN
θ value	3.0926 (rank : 1477)	NC score	0.017788 (rank : 1575)
Query Neighborhood Hits	1762	Target Neighborhood Hits	445	Shared Neighborhood Hits	60
SwissProt Accessions	Q01970	Gene names	PLCB3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

PTN23_HUMAN
θ value	3.0926 (rank : 1478)	NC score	0.029927 (rank : 1452)
Query Neighborhood Hits	1762	Target Neighborhood Hits	646	Shared Neighborhood Hits	190
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

QSCN6_HUMAN
θ value	3.0926 (rank : 1479)	NC score	0.004259 (rank : 1779)
Query Neighborhood Hits	1762	Target Neighborhood Hits	98	Shared Neighborhood Hits	24
SwissProt Accessions	O00391, Q59G29, Q5T2X0, Q8TDL6, Q8WVP4	Gene names	QSCN6, QSOX1
Domain Architecture	No domain graphic available
Description	Sulfhydryl oxidase 1 precursor (EC 1.8.3.2) (Quiescin Q6) (hQSOX).

RIMB1_MOUSE
θ value	3.0926 (rank : 1480)	NC score	0.034616 (rank : 1416)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1376	Shared Neighborhood Hits	222
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SOX13_HUMAN
θ value	3.0926 (rank : 1481)	NC score	0.012028 (rank : 1657)
Query Neighborhood Hits	1762	Target Neighborhood Hits	464	Shared Neighborhood Hits	126
SwissProt Accessions	Q9UN79, O95275, O95826, Q9UHW7	Gene names	SOX13
Domain Architecture
Description	SOX-13 protein (Type 1 diabetes autoantigen ICA12) (Islet cell antigen 12).

SRBS1_MOUSE
θ value	3.0926 (rank : 1482)	NC score	0.025350 (rank : 1492)
Query Neighborhood Hits	1762	Target Neighborhood Hits	409	Shared Neighborhood Hits	109
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SSBP4_HUMAN
θ value	3.0926 (rank : 1483)	NC score	0.020249 (rank : 1547)
Query Neighborhood Hits	1762	Target Neighborhood Hits	753	Shared Neighborhood Hits	219
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

SYN3_HUMAN
θ value	3.0926 (rank : 1484)	NC score	0.029115 (rank : 1462)
Query Neighborhood Hits	1762	Target Neighborhood Hits	203	Shared Neighborhood Hits	96
SwissProt Accessions	O14994	Gene names	SYN3
Domain Architecture
Description	Synapsin-3 (Synapsin III).

TARA_MOUSE
θ value	3.0926 (rank : 1485)	NC score	0.039913 (rank : 1377)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1133	Shared Neighborhood Hits	257
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TSC1_HUMAN
θ value	3.0926 (rank : 1486)	NC score	0.026011 (rank : 1489)
Query Neighborhood Hits	1762	Target Neighborhood Hits	765	Shared Neighborhood Hits	120
SwissProt Accessions	Q92574	Gene names	TSC1, KIAA0243, TSC
Domain Architecture
Description	Hamartin (Tuberous sclerosis 1 protein).

VASP_HUMAN
θ value	3.0926 (rank : 1487)	NC score	0.021689 (rank : 1528)
Query Neighborhood Hits	1762	Target Neighborhood Hits	201	Shared Neighborhood Hits	93
SwissProt Accessions	P50552, Q6PIZ1, Q93035	Gene names	VASP
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

WASL_HUMAN
θ value	3.0926 (rank : 1488)	NC score	0.063332 (rank : 1237)
Query Neighborhood Hits	1762	Target Neighborhood Hits	312	Shared Neighborhood Hits	189
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

ZBT7A_HUMAN
θ value	3.0926 (rank : 1489)	NC score	-0.028938 (rank : 1941)
Query Neighborhood Hits	1762	Target Neighborhood Hits	823	Shared Neighborhood Hits	40
SwissProt Accessions	O95365, O00456	Gene names	ZBTB7A, FBI1, LRF, ZBTB7
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 7A (Leukemia/lymphoma- related factor) (Factor that binds to inducer of short transcripts protein 1) (Factor binding IST protein 1) (FBI-1) (HIV-1 1st-binding protein 1) (TTF-I-interacting peptide 21) (TIP21).

2DMB_MOUSE
θ value	4.03905 (rank : 1490)	NC score	-0.009047 (rank : 1900)
Query Neighborhood Hits	1762	Target Neighborhood Hits	214	Shared Neighborhood Hits	15
SwissProt Accessions	P35737	Gene names	H2-DMb1, H-2Mb1, Mb
Domain Architecture
Description	Class II histocompatibility antigen, M beta 1 chain precursor (H2-M beta 1 chain).

ACV1B_HUMAN
θ value	4.03905 (rank : 1491)	NC score	0.599788 (rank : 787)
Query Neighborhood Hits	1762	Target Neighborhood Hits	753	Shared Neighborhood Hits	735
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

ACV1B_MOUSE
θ value	4.03905 (rank : 1492)	NC score	0.600050 (rank : 786)
Query Neighborhood Hits	1762	Target Neighborhood Hits	753	Shared Neighborhood Hits	735
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

ARMX2_MOUSE
θ value	4.03905 (rank : 1493)	NC score	0.019104 (rank : 1559)
Query Neighborhood Hits	1762	Target Neighborhood Hits	349	Shared Neighborhood Hits	114
SwissProt Accessions	Q6A058, Q9CXI9	Gene names	Armcx2, Kiaa0512
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing X-linked protein 2.

B4GN4_MOUSE
θ value	4.03905 (rank : 1494)	NC score	0.003672 (rank : 1791)
Query Neighborhood Hits	1762	Target Neighborhood Hits	129	Shared Neighborhood Hits	33
SwissProt Accessions	Q766D5, Q8CHV2	Gene names	B4galnt4
Domain Architecture	No domain graphic available
Description	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferase 1 (EC 2.4.1.244) (NGalNAc-T1) (Beta- 1,4-N-acetylgalactosaminyltransferase IV) (Beta4GalNAc-T4) (Beta4GalNAcT4).

C2TA_MOUSE
θ value	4.03905 (rank : 1495)	NC score	-0.001306 (rank : 1861)
Query Neighborhood Hits	1762	Target Neighborhood Hits	131	Shared Neighborhood Hits	21
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

CAC1B_HUMAN
θ value	4.03905 (rank : 1496)	NC score	0.005812 (rank : 1750)
Query Neighborhood Hits	1762	Target Neighborhood Hits	257	Shared Neighborhood Hits	76
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CNOT3_HUMAN
θ value	4.03905 (rank : 1497)	NC score	0.045444 (rank : 1344)
Query Neighborhood Hits	1762	Target Neighborhood Hits	425	Shared Neighborhood Hits	134
SwissProt Accessions	O75175, Q9NZN7, Q9UF76	Gene names	CNOT3, KIAA0691, NOT3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

CO5A1_MOUSE
θ value	4.03905 (rank : 1498)	NC score	0.007289 (rank : 1726)
Query Neighborhood Hits	1762	Target Neighborhood Hits	419	Shared Neighborhood Hits	146
SwissProt Accessions	O88207	Gene names	Col5a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(V) chain precursor.

CT174_HUMAN
θ value	4.03905 (rank : 1499)	NC score	0.026549 (rank : 1484)
Query Neighborhood Hits	1762	Target Neighborhood Hits	181	Shared Neighborhood Hits	82
SwissProt Accessions	Q5JPB2, Q5TDR4, Q8TCP0	Gene names	C20orf174
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf174.

CTGE4_HUMAN
θ value	4.03905 (rank : 1500)	NC score	0.008866 (rank : 1700)
Query Neighborhood Hits	1762	Target Neighborhood Hits	393	Shared Neighborhood Hits	38
SwissProt Accessions	Q8IX94, O95046	Gene names	CTAGE4
Domain Architecture	No domain graphic available
Description	Cutaneous T-cell lymphoma-associated antigen 4 (cTAGE-4 protein).

DIAP1_HUMAN
θ value	4.03905 (rank : 1501)	NC score	0.021770 (rank : 1527)
Query Neighborhood Hits	1762	Target Neighborhood Hits	784	Shared Neighborhood Hits	177
SwissProt Accessions	O60610, Q9UC76	Gene names	DIAPH1, DIAP1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).

DIAP2_HUMAN
θ value	4.03905 (rank : 1502)	NC score	0.010571 (rank : 1678)
Query Neighborhood Hits	1762	Target Neighborhood Hits	342	Shared Neighborhood Hits	80
SwissProt Accessions	O60879, O60878, Q8WX06, Q8WX48, Q9UJL2	Gene names	DIAPH2, DIA
Domain Architecture
Description	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2).

DOK1_HUMAN
θ value	4.03905 (rank : 1503)	NC score	0.004674 (rank : 1774)
Query Neighborhood Hits	1762	Target Neighborhood Hits	85	Shared Neighborhood Hits	27
SwissProt Accessions	Q99704, O43204, Q9UHG6	Gene names	DOK1
Domain Architecture
Description	Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62).

ETV5_MOUSE
θ value	4.03905 (rank : 1504)	NC score	0.003425 (rank : 1797)
Query Neighborhood Hits	1762	Target Neighborhood Hits	328	Shared Neighborhood Hits	87
SwissProt Accessions	Q9CXC9, Q3TG49, Q8C0F3, Q9JHB1	Gene names	Etv5
Domain Architecture	No domain graphic available
Description	ETS translocation variant 5.

FBX41_MOUSE
θ value	4.03905 (rank : 1505)	NC score	0.012958 (rank : 1636)
Query Neighborhood Hits	1762	Target Neighborhood Hits	430	Shared Neighborhood Hits	62
SwissProt Accessions	Q6NS60, Q6P7W4, Q6ZPG1	Gene names	Fbxo41, D6Ertd538e, Kiaa1940
Domain Architecture	No domain graphic available
Description	F-box only protein 41.

FINC_MOUSE
θ value	4.03905 (rank : 1506)	NC score	0.151975 (rank : 1050)
Query Neighborhood Hits	1762	Target Neighborhood Hits	309	Shared Neighborhood Hits	157
SwissProt Accessions	P11276, Q61567, Q61568, Q61569, Q64233, Q80UI4	Gene names	Fn1
Domain Architecture
Description	Fibronectin precursor (FN).

FOXD2_MOUSE
θ value	4.03905 (rank : 1507)	NC score	-0.000891 (rank : 1853)
Query Neighborhood Hits	1762	Target Neighborhood Hits	130	Shared Neighborhood Hits	30
SwissProt Accessions	O35392	Gene names	Foxd2, Mf2
Domain Architecture
Description	Forkhead box protein D2 (Mesoderm/mesenchyme forkhead 2) (MF-2).

FXR2_MOUSE
θ value	4.03905 (rank : 1508)	NC score	0.002556 (rank : 1808)
Query Neighborhood Hits	1762	Target Neighborhood Hits	66	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WVR4, Q9WVR5	Gene names	Fxr2, Fxr2h
Domain Architecture
Description	Fragile X mental retardation syndrome-related protein 2.

GAK1_HUMAN
θ value	4.03905 (rank : 1509)	NC score	0.010088 (rank : 1684)
Query Neighborhood Hits	1762	Target Neighborhood Hits	268	Shared Neighborhood Hits	81
SwissProt Accessions	P62683	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_12q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GEMI5_MOUSE
θ value	4.03905 (rank : 1510)	NC score	-0.008989 (rank : 1899)
Query Neighborhood Hits	1762	Target Neighborhood Hits	424	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BX17	Gene names	Gemin5
Domain Architecture
Description	Gem-associated protein 5 (Gemin5).

IF16_HUMAN
θ value	4.03905 (rank : 1511)	NC score	0.010552 (rank : 1679)
Query Neighborhood Hits	1762	Target Neighborhood Hits	182	Shared Neighborhood Hits	68
SwissProt Accessions	Q16666, Q9UH78	Gene names	IFI16, IFNGIP1
Domain Architecture
Description	Gamma-interferon-inducible protein Ifi-16 (Interferon-inducible myeloid differentiation transcriptional activator) (IFI 16).

INCE_HUMAN
θ value	4.03905 (rank : 1512)	NC score	0.029717 (rank : 1453)
Query Neighborhood Hits	1762	Target Neighborhood Hits	978	Shared Neighborhood Hits	119
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

JAML1_MOUSE
θ value	4.03905 (rank : 1513)	NC score	0.097922 (rank : 1127)
Query Neighborhood Hits	1762	Target Neighborhood Hits	185	Shared Neighborhood Hits	108
SwissProt Accessions	Q80UL9, Q5DTC4	Gene names	Amica1, Gm638, Jaml
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule-like precursor (mCrea7).

K1688_MOUSE
θ value	4.03905 (rank : 1514)	NC score	0.006405 (rank : 1740)
Query Neighborhood Hits	1762	Target Neighborhood Hits	188	Shared Neighborhood Hits	52
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

LPIN3_MOUSE
θ value	4.03905 (rank : 1515)	NC score	0.001416 (rank : 1824)
Query Neighborhood Hits	1762	Target Neighborhood Hits	52	Shared Neighborhood Hits	12
SwissProt Accessions	Q99PI4, Q3TQ75, Q8C7R9	Gene names	Lpin3
Domain Architecture
Description	Lipin-3.

LR37A_HUMAN
θ value	4.03905 (rank : 1516)	NC score	0.048205 (rank : 1331)
Query Neighborhood Hits	1762	Target Neighborhood Hits	720	Shared Neighborhood Hits	222
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

NFM_HUMAN
θ value	4.03905 (rank : 1517)	NC score	0.011004 (rank : 1670)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1328	Shared Neighborhood Hits	200
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

NOTC4_HUMAN
θ value	4.03905 (rank : 1518)	NC score	0.000788 (rank : 1836)
Query Neighborhood Hits	1762	Target Neighborhood Hits	905	Shared Neighborhood Hits	85
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

OTU7A_HUMAN
θ value	4.03905 (rank : 1519)	NC score	0.005269 (rank : 1764)
Query Neighborhood Hits	1762	Target Neighborhood Hits	74	Shared Neighborhood Hits	19
SwissProt Accessions	Q8TE49, Q8IWK5	Gene names	OTUD7A, C15orf16, OTUD7
Domain Architecture	No domain graphic available
Description	OTU domain-containing protein 7A (EC 3.-.-.-) (Zinc finger protein Cezanne 2).

PHLB1_MOUSE
θ value	4.03905 (rank : 1520)	NC score	0.027313 (rank : 1474)
Query Neighborhood Hits	1762	Target Neighborhood Hits	678	Shared Neighborhood Hits	142
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PO121_MOUSE
θ value	4.03905 (rank : 1521)	NC score	0.043210 (rank : 1353)
Query Neighborhood Hits	1762	Target Neighborhood Hits	345	Shared Neighborhood Hits	143
SwissProt Accessions	Q8K3Z9, Q7TSH5	Gene names	Pom121, Nup121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa).

PP16A_MOUSE
θ value	4.03905 (rank : 1522)	NC score	0.005859 (rank : 1749)
Query Neighborhood Hits	1762	Target Neighborhood Hits	318	Shared Neighborhood Hits	31
SwissProt Accessions	Q923M0, Q4V9Z1	Gene names	Ppp1r16a, Mypt3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase targeting subunit 3).

PRR3_MOUSE
θ value	4.03905 (rank : 1523)	NC score	0.004134 (rank : 1780)
Query Neighborhood Hits	1762	Target Neighborhood Hits	39	Shared Neighborhood Hits	8
SwissProt Accessions	Q811B5, Q91YI5	Gene names	Prr3, Cat56
Domain Architecture	No domain graphic available
Description	Proline-rich protein 3 (MHC class I region proline-rich protein CAT56).

RAI1_MOUSE
θ value	4.03905 (rank : 1524)	NC score	0.017476 (rank : 1583)
Query Neighborhood Hits	1762	Target Neighborhood Hits	344	Shared Neighborhood Hits	117
SwissProt Accessions	Q61818, Q6ZPH7, Q8CEV1	Gene names	Rai1, Kiaa1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

RNF12_MOUSE
θ value	4.03905 (rank : 1525)	NC score	-0.001214 (rank : 1858)
Query Neighborhood Hits	1762	Target Neighborhood Hits	159	Shared Neighborhood Hits	15
SwissProt Accessions	Q9WTV7	Gene names	Rnf12, Rlim
Domain Architecture
Description	RING finger protein 12 (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM).

S23IP_MOUSE
θ value	4.03905 (rank : 1526)	NC score	0.016858 (rank : 1592)
Query Neighborhood Hits	1762	Target Neighborhood Hits	363	Shared Neighborhood Hits	115
SwissProt Accessions	Q6NZC7, Q8BXY6	Gene names	Sec23ip
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein.

SF01_HUMAN
θ value	4.03905 (rank : 1527)	NC score	0.047502 (rank : 1336)
Query Neighborhood Hits	1762	Target Neighborhood Hits	287	Shared Neighborhood Hits	146
SwissProt Accessions	Q15637, Q14818, Q14819, Q15913, Q8IY00, Q92744, Q92745, Q969H7, Q9BW01, Q9UEI0	Gene names	SF1, ZFM1, ZNF162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Mammalian branch point-binding protein mBBP) (BBP).

SNIP_MOUSE
θ value	4.03905 (rank : 1528)	NC score	0.018681 (rank : 1564)
Query Neighborhood Hits	1762	Target Neighborhood Hits	319	Shared Neighborhood Hits	83
SwissProt Accessions	Q9QWI6, O70298	Gene names	P140, Kiaa1684
Domain Architecture	No domain graphic available
Description	p130Cas-associated protein (p140Cap) (SNAP-25-interacting protein) (SNIP).

SYP2L_HUMAN
θ value	4.03905 (rank : 1529)	NC score	0.032261 (rank : 1433)
Query Neighborhood Hits	1762	Target Neighborhood Hits	400	Shared Neighborhood Hits	157
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

SYTL1_HUMAN
θ value	4.03905 (rank : 1530)	NC score	0.012569 (rank : 1643)
Query Neighborhood Hits	1762	Target Neighborhood Hits	227	Shared Neighborhood Hits	62
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

TM108_HUMAN
θ value	4.03905 (rank : 1531)	NC score	0.037747 (rank : 1393)
Query Neighborhood Hits	1762	Target Neighborhood Hits	166	Shared Neighborhood Hits	89
SwissProt Accessions	Q6UXF1, Q9BQH1, Q9BW81, Q9C0H3	Gene names	TMEM108, KIAA1690
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

TMM92_HUMAN
θ value	4.03905 (rank : 1532)	NC score	0.009568 (rank : 1689)
Query Neighborhood Hits	1762	Target Neighborhood Hits	6	Shared Neighborhood Hits	4
SwissProt Accessions	Q6UXU6, Q8NBF0	Gene names	TMEM92
Domain Architecture	No domain graphic available
Description	Transmembrane protein 92 precursor.

UBP8_MOUSE
θ value	4.03905 (rank : 1533)	NC score	-0.003555 (rank : 1880)
Query Neighborhood Hits	1762	Target Neighborhood Hits	362	Shared Neighborhood Hits	48
SwissProt Accessions	Q80U87, Q80YP2, Q8R0D3, Q9EQU1, Q9WVP5	Gene names	Usp8, Kiaa0055, Ubpy
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (mUBPy).

UNC5C_HUMAN
θ value	4.03905 (rank : 1534)	NC score	0.116695 (rank : 1095)
Query Neighborhood Hits	1762	Target Neighborhood Hits	226	Shared Neighborhood Hits	138
SwissProt Accessions	O95185, Q8IUT0	Gene names	UNC5C, UNC5H3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3).

WASP_MOUSE
θ value	4.03905 (rank : 1535)	NC score	0.038318 (rank : 1388)
Query Neighborhood Hits	1762	Target Neighborhood Hits	223	Shared Neighborhood Hits	129
SwissProt Accessions	P70315	Gene names	Was, Wasp
Domain Architecture
Description	Wiskott-Aldrich syndrome protein homolog (WASp).

YLPM1_MOUSE
θ value	4.03905 (rank : 1536)	NC score	0.058035 (rank : 1269)
Query Neighborhood Hits	1762	Target Neighborhood Hits	505	Shared Neighborhood Hits	207
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

ZBT7A_MOUSE
θ value	4.03905 (rank : 1537)	NC score	-0.029095 (rank : 1942)
Query Neighborhood Hits	1762	Target Neighborhood Hits	795	Shared Neighborhood Hits	32
SwissProt Accessions	O88939, Q9CRJ0	Gene names	Zbtb7a, Lrf, Zbtb7
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 7A (Leukemia/lymphoma- related factor).

ZN250_MOUSE
θ value	4.03905 (rank : 1538)	NC score	-0.027493 (rank : 1939)
Query Neighborhood Hits	1762	Target Neighborhood Hits	773	Shared Neighborhood Hits	39
SwissProt Accessions	Q7TNU6, Q8BJ57	Gene names	Znf250, Zfp647, Znf647
Domain Architecture	No domain graphic available
Description	Zinc finger protein 250 (Zinc finger protein 647).

ZN598_HUMAN
θ value	4.03905 (rank : 1539)	NC score	0.020162 (rank : 1550)
Query Neighborhood Hits	1762	Target Neighborhood Hits	339	Shared Neighborhood Hits	91
SwissProt Accessions	Q86UK7, Q8IW49, Q8N3D9, Q96FG3, Q9H7J3	Gene names	ZNF598
Domain Architecture	No domain graphic available
Description	Zinc finger protein 598.

3MG_HUMAN
θ value	5.27518 (rank : 1540)	NC score	0.005962 (rank : 1745)
Query Neighborhood Hits	1762	Target Neighborhood Hits	32	Shared Neighborhood Hits	15
SwissProt Accessions	P29372, Q13770, Q15275, Q15961, Q96BZ6, Q96S33, Q9NNX5	Gene names	MPG, AAG, ANPG, MID1
Domain Architecture
Description	DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-methyladenine DNA glycosidase) (ADPG) (3-alkyladenine DNA glycosylase) (N-methylpurine- DNA glycosylase).

ACV1C_HUMAN
θ value	5.27518 (rank : 1541)	NC score	0.541719 (rank : 814)
Query Neighborhood Hits	1762	Target Neighborhood Hits	709	Shared Neighborhood Hits	684
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

AMGO3_MOUSE
θ value	5.27518 (rank : 1542)	NC score	0.042202 (rank : 1360)
Query Neighborhood Hits	1762	Target Neighborhood Hits	276	Shared Neighborhood Hits	80
SwissProt Accessions	Q8C2S7, Q6ZPH1, Q8CEB3	Gene names	Amigo3, Ali3, Kiaa1851
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 3 precursor (AMIGO-3) (Alivin-3).

ANR43_HUMAN
θ value	5.27518 (rank : 1543)	NC score	0.005938 (rank : 1746)
Query Neighborhood Hits	1762	Target Neighborhood Hits	209	Shared Neighborhood Hits	26
SwissProt Accessions	Q2M3V2, Q8NAE7	Gene names	ANKRD43
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 43.

ASPP1_MOUSE
θ value	5.27518 (rank : 1544)	NC score	0.047385 (rank : 1337)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1244	Shared Neighborhood Hits	283
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASTL_HUMAN
θ value	5.27518 (rank : 1545)	NC score	0.013394 (rank : 1628)
Query Neighborhood Hits	1762	Target Neighborhood Hits	252	Shared Neighborhood Hits	103
SwissProt Accessions	Q6HA08	Gene names	ASTL
Domain Architecture	No domain graphic available
Description	Astacin-like metalloendopeptidase precursor (EC 3.4.-.-) (Oocyte astacin) (Ovastacin).

BBS10_MOUSE
θ value	5.27518 (rank : 1546)	NC score	0.000955 (rank : 1833)
Query Neighborhood Hits	1762	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	Q9DBI2	Gene names	Bbs10
Domain Architecture	No domain graphic available
Description	Bardet-Biedl syndrome 10 protein homolog.

CAC1G_HUMAN
θ value	5.27518 (rank : 1547)	NC score	0.011489 (rank : 1665)
Query Neighborhood Hits	1762	Target Neighborhood Hits	587	Shared Neighborhood Hits	184
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

CAC1H_HUMAN
θ value	5.27518 (rank : 1548)	NC score	0.006960 (rank : 1734)
Query Neighborhood Hits	1762	Target Neighborhood Hits	307	Shared Neighborhood Hits	102
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

CDC20_HUMAN
θ value	5.27518 (rank : 1549)	NC score	-0.012938 (rank : 1908)
Query Neighborhood Hits	1762	Target Neighborhood Hits	329	Shared Neighborhood Hits	28
SwissProt Accessions	Q12834, Q9BW56, Q9UQI9	Gene names	CDC20
Domain Architecture
Description	Cell division cycle protein 20 homolog (p55CDC).

CO1A1_MOUSE
θ value	5.27518 (rank : 1550)	NC score	0.013266 (rank : 1631)
Query Neighborhood Hits	1762	Target Neighborhood Hits	457	Shared Neighborhood Hits	154
SwissProt Accessions	P11087, Q53WT0, Q60635, Q61367, Q61427, Q63919, Q6PCL3, Q810J9	Gene names	Col1a1, Cola1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

CO6A3_HUMAN
θ value	5.27518 (rank : 1551)	NC score	-0.002785 (rank : 1871)
Query Neighborhood Hits	1762	Target Neighborhood Hits	317	Shared Neighborhood Hits	79
SwissProt Accessions	P12111, Q16501	Gene names	COL6A3
Domain Architecture
Description	Collagen alpha-3(VI) chain precursor.

CS007_HUMAN
θ value	5.27518 (rank : 1552)	NC score	0.031883 (rank : 1437)
Query Neighborhood Hits	1762	Target Neighborhood Hits	401	Shared Neighborhood Hits	156
SwissProt Accessions	Q9UPT8, Q9Y420	Gene names	C19orf7, KIAA1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7.

CSF1_HUMAN
θ value	5.27518 (rank : 1553)	NC score	0.023205 (rank : 1515)
Query Neighborhood Hits	1762	Target Neighborhood Hits	258	Shared Neighborhood Hits	115
SwissProt Accessions	P09603, Q13130, Q14086, Q14806, Q9UQR8	Gene names	CSF1
Domain Architecture
Description	Macrophage colony-stimulating factor 1 precursor (CSF-1) (MCSF) (M- CSF) (Lanimostim).

DDX46_MOUSE
θ value	5.27518 (rank : 1554)	NC score	-0.003165 (rank : 1876)
Query Neighborhood Hits	1762	Target Neighborhood Hits	358	Shared Neighborhood Hits	49
SwissProt Accessions	Q569Z5, Q6ZQ42, Q8R0R6	Gene names	Ddx46, Kiaa0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46).

DDX51_HUMAN
θ value	5.27518 (rank : 1555)	NC score	0.001667 (rank : 1822)
Query Neighborhood Hits	1762	Target Neighborhood Hits	332	Shared Neighborhood Hits	84
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DEND_HUMAN
θ value	5.27518 (rank : 1556)	NC score	0.007350 (rank : 1725)
Query Neighborhood Hits	1762	Target Neighborhood Hits	88	Shared Neighborhood Hits	30
SwissProt Accessions	O94850	Gene names	DDN, KIAA0749
Domain Architecture	No domain graphic available
Description	Dendrin.

DREB_HUMAN
θ value	5.27518 (rank : 1557)	NC score	0.037721 (rank : 1394)
Query Neighborhood Hits	1762	Target Neighborhood Hits	450	Shared Neighborhood Hits	91
SwissProt Accessions	Q16643	Gene names	DBN1
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

DUX4_HUMAN
θ value	5.27518 (rank : 1558)	NC score	-0.011454 (rank : 1904)
Query Neighborhood Hits	1762	Target Neighborhood Hits	403	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UBX2	Gene names	DUX4, DUX10
Domain Architecture	No domain graphic available
Description	Double homeobox protein 4 (Double homeobox protein 10) (Double homeobox protein 4/10).

ENAH_MOUSE
θ value	5.27518 (rank : 1559)	NC score	0.060939 (rank : 1246)
Query Neighborhood Hits	1762	Target Neighborhood Hits	919	Shared Neighborhood Hits	271
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

ETV1_HUMAN
θ value	5.27518 (rank : 1560)	NC score	-0.001135 (rank : 1855)
Query Neighborhood Hits	1762	Target Neighborhood Hits	107	Shared Neighborhood Hits	25
SwissProt Accessions	P50549, O75849, Q9UQ71, Q9Y636	Gene names	ETV1, ER81
Domain Architecture
Description	ETS translocation variant 1 (ER81 protein).

EYA4_MOUSE
θ value	5.27518 (rank : 1561)	NC score	0.001038 (rank : 1831)
Query Neighborhood Hits	1762	Target Neighborhood Hits	74	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z191	Gene names	Eya4
Domain Architecture
Description	Eyes absent homolog 4 (EC 3.1.3.48).

FRAT1_MOUSE
θ value	5.27518 (rank : 1562)	NC score	0.002038 (rank : 1816)
Query Neighborhood Hits	1762	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	P70339	Gene names	Frat1
Domain Architecture
Description	Proto-oncogene FRAT1 (Frequently rearranged in advanced T-cell lymphomas) (Frat-1).

GA2L2_MOUSE
θ value	5.27518 (rank : 1563)	NC score	0.026858 (rank : 1479)
Query Neighborhood Hits	1762	Target Neighborhood Hits	395	Shared Neighborhood Hits	156
SwissProt Accessions	Q5SSG4	Gene names	Gas2l2
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2).

GP116_HUMAN
θ value	5.27518 (rank : 1564)	NC score	0.037890 (rank : 1391)
Query Neighborhood Hits	1762	Target Neighborhood Hits	167	Shared Neighborhood Hits	67
SwissProt Accessions	Q8IZF2, O94858, Q6RGN2, Q86SP0, Q9Y3Z2	Gene names	GPR116, KIAA0758
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 116 precursor.

HRX_HUMAN
θ value	5.27518 (rank : 1565)	NC score	0.016436 (rank : 1597)
Query Neighborhood Hits	1762	Target Neighborhood Hits	825	Shared Neighborhood Hits	202
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

I20RA_MOUSE
θ value	5.27518 (rank : 1566)	NC score	0.008882 (rank : 1699)
Query Neighborhood Hits	1762	Target Neighborhood Hits	37	Shared Neighborhood Hits	12
SwissProt Accessions	Q6PHB0, Q8BW64	Gene names	Il20ra
Domain Architecture	No domain graphic available
Description	Interleukin-20 receptor alpha chain precursor (IL-20R-alpha) (IL- 20R1).

IF4G1_MOUSE
θ value	5.27518 (rank : 1567)	NC score	0.020425 (rank : 1543)
Query Neighborhood Hits	1762	Target Neighborhood Hits	534	Shared Neighborhood Hits	165
SwissProt Accessions	Q6NZJ6, Q6NZN8, Q8BW99	Gene names	Eif4g1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1).

IRX5_HUMAN
θ value	5.27518 (rank : 1568)	NC score	0.004674 (rank : 1775)
Query Neighborhood Hits	1762	Target Neighborhood Hits	362	Shared Neighborhood Hits	83
SwissProt Accessions	P78411, P78416, Q7Z2E1	Gene names	IRX5, IRX2A, IRXB2
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-5 (Iroquois homeobox protein 5) (Homeodomain protein IRXB2) (IRX-2A).

KLF12_MOUSE
θ value	5.27518 (rank : 1569)	NC score	-0.024680 (rank : 1930)
Query Neighborhood Hits	1762	Target Neighborhood Hits	721	Shared Neighborhood Hits	44
SwissProt Accessions	O35738	Gene names	Klf12, Ap2rep
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 12 (Transcriptional repressor AP-2rep).

LARP1_HUMAN
θ value	5.27518 (rank : 1570)	NC score	0.009494 (rank : 1690)
Query Neighborhood Hits	1762	Target Neighborhood Hits	242	Shared Neighborhood Hits	56
SwissProt Accessions	Q6PKG0, O94836, Q8N4M2, Q8NB73, Q9UFD7	Gene names	LARP1, KIAA0731, LARP
Domain Architecture	No domain graphic available
Description	La-related protein 1 (La ribonucleoprotein domain family member 1).

LR37B_HUMAN
θ value	5.27518 (rank : 1571)	NC score	0.032548 (rank : 1427)
Query Neighborhood Hits	1762	Target Neighborhood Hits	392	Shared Neighborhood Hits	109
SwissProt Accessions	Q96QE4, Q5YKG6	Gene names	LRRC37B
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37B precursor (C66 SLIT-like testicular protein).

LRRC4_MOUSE
θ value	5.27518 (rank : 1572)	NC score	0.090113 (rank : 1138)
Query Neighborhood Hits	1762	Target Neighborhood Hits	412	Shared Neighborhood Hits	173
SwissProt Accessions	Q99PH1, Q8VI35	Gene names	Lrrc4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing 4 protein precursor (Brain tumor- associated protein MBAG1).

MEOX1_MOUSE
θ value	5.27518 (rank : 1573)	NC score	-0.016797 (rank : 1913)
Query Neighborhood Hits	1762	Target Neighborhood Hits	345	Shared Neighborhood Hits	18
SwissProt Accessions	P32442	Gene names	Meox1, Mox-1, Mox1
Domain Architecture
Description	Homeobox protein MOX-1 (Mesenchyme homeobox 1).

NECP2_MOUSE
θ value	5.27518 (rank : 1574)	NC score	0.003649 (rank : 1792)
Query Neighborhood Hits	1762	Target Neighborhood Hits	16	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D1J1, Q3U1M1, Q9CV41	Gene names	Necap2
Domain Architecture	No domain graphic available
Description	Adaptin ear-binding coat-associated protein 2 (NECAP-2).

NMDE4_HUMAN
θ value	5.27518 (rank : 1575)	NC score	-0.000764 (rank : 1850)
Query Neighborhood Hits	1762	Target Neighborhood Hits	133	Shared Neighborhood Hits	46
SwissProt Accessions	O15399	Gene names	GRIN2D
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 4 precursor (N-methyl D- aspartate receptor subtype 2D) (NR2D) (NMDAR2D) (EB11).

NPFF1_HUMAN
θ value	5.27518 (rank : 1576)	NC score	-0.028500 (rank : 1940)
Query Neighborhood Hits	1762	Target Neighborhood Hits	858	Shared Neighborhood Hits	8
SwissProt Accessions	Q9GZQ6, Q8NGR0, Q96RN3	Gene names	NPFFR1, GPR147, NPFF1
Domain Architecture
Description	Neuropeptide FF receptor 1 (G-protein coupled receptor 147) (RFamide- related peptide receptor OT7T022).

NTKL_MOUSE
θ value	5.27518 (rank : 1577)	NC score	0.339433 (rank : 916)
Query Neighborhood Hits	1762	Target Neighborhood Hits	326	Shared Neighborhood Hits	292
SwissProt Accessions	Q9EQC5, Q3TST7, Q3UKU0, Q8K222	Gene names	Scyl1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (105 kDa kinase- like protein) (Mitosis-associated kinase-like protein NTKL).

PGFRL_HUMAN
θ value	5.27518 (rank : 1578)	NC score	0.150419 (rank : 1053)
Query Neighborhood Hits	1762	Target Neighborhood Hits	115	Shared Neighborhood Hits	111
SwissProt Accessions	Q15198, Q6FH04	Gene names	PDGFRL, PRLTS
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor (PDGF receptor beta-like tumor suppressor).

PKP4_HUMAN
θ value	5.27518 (rank : 1579)	NC score	0.000513 (rank : 1838)
Query Neighborhood Hits	1762	Target Neighborhood Hits	107	Shared Neighborhood Hits	28
SwissProt Accessions	Q99569	Gene names	PKP4
Domain Architecture
Description	Plakophilin-4 (p0071).

PPRB_HUMAN
θ value	5.27518 (rank : 1580)	NC score	0.036394 (rank : 1406)
Query Neighborhood Hits	1762	Target Neighborhood Hits	311	Shared Neighborhood Hits	102
SwissProt Accessions	Q15648, O43810, O75447, Q9HD39	Gene names	PPARBP, ARC205, DRIP205, TRAP220, TRIP2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2) (p53 regulatory protein RB18A) (Vitamin D receptor-interacting protein complex component DRIP205) (Activator- recruited cofactor 205 kDa component) (ARC205).

PRB4S_HUMAN
θ value	5.27518 (rank : 1581)	NC score	0.078361 (rank : 1162)
Query Neighborhood Hits	1762	Target Neighborhood Hits	330	Shared Neighborhood Hits	178
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

PTPRM_HUMAN
θ value	5.27518 (rank : 1582)	NC score	0.101853 (rank : 1119)
Query Neighborhood Hits	1762	Target Neighborhood Hits	244	Shared Neighborhood Hits	136
SwissProt Accessions	P28827	Gene names	PTPRM, PTPRL1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTPRM_MOUSE
θ value	5.27518 (rank : 1583)	NC score	0.099420 (rank : 1125)
Query Neighborhood Hits	1762	Target Neighborhood Hits	238	Shared Neighborhood Hits	135
SwissProt Accessions	P28828	Gene names	Ptprm
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PZRN4_HUMAN
θ value	5.27518 (rank : 1584)	NC score	-0.007615 (rank : 1895)
Query Neighborhood Hits	1762	Target Neighborhood Hits	438	Shared Neighborhood Hits	29
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

RTN2_HUMAN
θ value	5.27518 (rank : 1585)	NC score	0.010770 (rank : 1674)
Query Neighborhood Hits	1762	Target Neighborhood Hits	59	Shared Neighborhood Hits	26
SwissProt Accessions	O75298, O60509, Q7RTM6, Q7RTN1, Q7RTN2	Gene names	RTN2, NSPL1
Domain Architecture
Description	Reticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like protein 1) (NSPLI).

SC24A_MOUSE
θ value	5.27518 (rank : 1586)	NC score	0.021011 (rank : 1533)
Query Neighborhood Hits	1762	Target Neighborhood Hits	394	Shared Neighborhood Hits	150
SwissProt Accessions	Q3U2P1, Q3TQ05, Q3TRG7, Q8BIS0	Gene names	Sec24a
Domain Architecture	No domain graphic available
Description	Protein transport protein Sec24A (SEC24-related protein A).

SEPT9_MOUSE
θ value	5.27518 (rank : 1587)	NC score	0.014707 (rank : 1617)
Query Neighborhood Hits	1762	Target Neighborhood Hits	238	Shared Neighborhood Hits	78
SwissProt Accessions	Q80UG5, Q3URP2, Q80TM7, Q9QYX9	Gene names	Sept9, Kiaa0991, Sint1
Domain Architecture	No domain graphic available
Description	Septin-9 (SL3-3 integration site 1 protein).

SL9A1_MOUSE
θ value	5.27518 (rank : 1588)	NC score	0.001791 (rank : 1820)
Query Neighborhood Hits	1762	Target Neighborhood Hits	32	Shared Neighborhood Hits	6
SwissProt Accessions	Q61165	Gene names	Slc9a1, Nhe1
Domain Architecture
Description	Sodium/hydrogen exchanger 1 (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1).

SPAG5_MOUSE
θ value	5.27518 (rank : 1589)	NC score	0.011869 (rank : 1659)
Query Neighborhood Hits	1762	Target Neighborhood Hits	612	Shared Neighborhood Hits	63
SwissProt Accessions	Q7TME2, Q8CH61	Gene names	Spag5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Mastrin) (Mitotic spindle-associated protein p126) (MAP126).

SPRE3_MOUSE
θ value	5.27518 (rank : 1590)	NC score	0.012452 (rank : 1646)
Query Neighborhood Hits	1762	Target Neighborhood Hits	111	Shared Neighborhood Hits	54
SwissProt Accessions	Q6P6N5, Q7TNJ8	Gene names	Spred3
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 3 (Spred-3).

STAT2_MOUSE
θ value	5.27518 (rank : 1591)	NC score	0.004756 (rank : 1771)
Query Neighborhood Hits	1762	Target Neighborhood Hits	175	Shared Neighborhood Hits	52
SwissProt Accessions	Q9WVL2, Q64188, Q64189, Q64250	Gene names	Stat2
Domain Architecture
Description	Signal transducer and activator of transcription 2.

SYNJ1_MOUSE
θ value	5.27518 (rank : 1592)	NC score	0.044629 (rank : 1346)
Query Neighborhood Hits	1762	Target Neighborhood Hits	516	Shared Neighborhood Hits	228
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

TCOF_HUMAN
θ value	5.27518 (rank : 1593)	NC score	0.047878 (rank : 1333)
Query Neighborhood Hits	1762	Target Neighborhood Hits	543	Shared Neighborhood Hits	163
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

TENN_HUMAN
θ value	5.27518 (rank : 1594)	NC score	0.065598 (rank : 1230)
Query Neighborhood Hits	1762	Target Neighborhood Hits	453	Shared Neighborhood Hits	117
SwissProt Accessions	Q9UQP3, Q5R360	Gene names	TNN
Domain Architecture
Description	Tenascin-N precursor (TN-N).

ZAN_HUMAN
θ value	5.27518 (rank : 1595)	NC score	0.024678 (rank : 1500)
Query Neighborhood Hits	1762	Target Neighborhood Hits	679	Shared Neighborhood Hits	133
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

ZHX1_MOUSE
θ value	5.27518 (rank : 1596)	NC score	-0.004108 (rank : 1885)
Query Neighborhood Hits	1762	Target Neighborhood Hits	334	Shared Neighborhood Hits	29
SwissProt Accessions	P70121, Q8BQ68, Q8C6T4, Q8CJG3	Gene names	Zhx1
Domain Architecture
Description	Zinc fingers and homeoboxes protein 1.

ZN414_HUMAN
θ value	5.27518 (rank : 1597)	NC score	-0.007111 (rank : 1893)
Query Neighborhood Hits	1762	Target Neighborhood Hits	548	Shared Neighborhood Hits	63
SwissProt Accessions	Q96IQ9	Gene names	ZNF414
Domain Architecture	No domain graphic available
Description	Zinc finger protein 414.

ZN447_HUMAN
θ value	5.27518 (rank : 1598)	NC score	-0.019488 (rank : 1915)
Query Neighborhood Hits	1762	Target Neighborhood Hits	899	Shared Neighborhood Hits	107
SwissProt Accessions	Q8TBC5, Q9BRK7, Q9H9A0	Gene names	ZNF447
Domain Architecture	No domain graphic available
Description	Zinc finger protein 447.

AMGO2_HUMAN
θ value	6.88961 (rank : 1599)	NC score	0.056791 (rank : 1275)
Query Neighborhood Hits	1762	Target Neighborhood Hits	357	Shared Neighborhood Hits	134
SwissProt Accessions	Q86SJ2, Q7Z4A0, Q96CN8	Gene names	AMIGO2, ALI1
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 2 precursor (AMIGO-2) (Alivin-1) (Differentially expressed in gastric adenocarcinomas) (DEGA).

BAI1_HUMAN
θ value	6.88961 (rank : 1600)	NC score	0.010495 (rank : 1680)
Query Neighborhood Hits	1762	Target Neighborhood Hits	375	Shared Neighborhood Hits	120
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

BCAR1_HUMAN
θ value	6.88961 (rank : 1601)	NC score	0.034126 (rank : 1420)
Query Neighborhood Hits	1762	Target Neighborhood Hits	554	Shared Neighborhood Hits	188
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	6.88961 (rank : 1602)	NC score	0.031701 (rank : 1439)
Query Neighborhood Hits	1762	Target Neighborhood Hits	438	Shared Neighborhood Hits	157
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BRD8_HUMAN
θ value	6.88961 (rank : 1603)	NC score	0.006066 (rank : 1744)
Query Neighborhood Hits	1762	Target Neighborhood Hits	292	Shared Neighborhood Hits	55
SwissProt Accessions	Q9H0E9, O43178, Q15355, Q59GN0, Q969M9	Gene names	BRD8, SMAP
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8 (p120) (Skeletal muscle abundant protein) (Thyroid hormone receptor coactivating protein 120kDa) (TrCP120).

CAC1H_MOUSE
θ value	6.88961 (rank : 1604)	NC score	0.005177 (rank : 1765)
Query Neighborhood Hits	1762	Target Neighborhood Hits	230	Shared Neighborhood Hits	73
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

CAD23_MOUSE
θ value	6.88961 (rank : 1605)	NC score	-0.012101 (rank : 1907)
Query Neighborhood Hits	1762	Target Neighborhood Hits	208	Shared Neighborhood Hits	15
SwissProt Accessions	Q99PF4, Q99NH1, Q9D4N9	Gene names	Cdh23
Domain Architecture
Description	Cadherin-23 precursor (Otocadherin).

CE110_MOUSE
θ value	6.88961 (rank : 1606)	NC score	0.004986 (rank : 1766)
Query Neighborhood Hits	1762	Target Neighborhood Hits	170	Shared Neighborhood Hits	24
SwissProt Accessions	Q7TSH4, Q6A072	Gene names	Cep110, Cp110, Kiaa0419
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 110 kDa (Cep110 protein).

CG1_HUMAN
θ value	6.88961 (rank : 1607)	NC score	0.032345 (rank : 1431)
Query Neighborhood Hits	1762	Target Neighborhood Hits	222	Shared Neighborhood Hits	86
SwissProt Accessions	Q13495	Gene names	CXorf6, CG1
Domain Architecture	No domain graphic available
Description	CG1 protein (F18).

CLCN1_MOUSE
θ value	6.88961 (rank : 1608)	NC score	0.003096 (rank : 1800)
Query Neighborhood Hits	1762	Target Neighborhood Hits	61	Shared Neighborhood Hits	22
SwissProt Accessions	Q64347	Gene names	Clcn1, Clc1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

CO2A1_HUMAN
θ value	6.88961 (rank : 1609)	NC score	0.003822 (rank : 1789)
Query Neighborhood Hits	1762	Target Neighborhood Hits	486	Shared Neighborhood Hits	149
SwissProt Accessions	P02458, Q12985, Q14009, Q14044, Q14046, Q14056, Q14058, Q16672, Q6LBY1, Q6LBY2, Q6LBY3, Q99227, Q9UE38, Q9UE39, Q9UE40, Q9UE41, Q9UE42, Q9UE43	Gene names	COL2A1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

CRSP7_HUMAN
θ value	6.88961 (rank : 1610)	NC score	0.015233 (rank : 1610)
Query Neighborhood Hits	1762	Target Neighborhood Hits	247	Shared Neighborhood Hits	69
SwissProt Accessions	O95402	Gene names	CRSP7, ARC70
Domain Architecture
Description	CRSP complex subunit 7 (Cofactor required for Sp1 transcriptional activation subunit 7) (Transcriptional coactivator CRSP70) (Activator- recruited cofactor 70 kDa component) (ARC70).

CS021_HUMAN
θ value	6.88961 (rank : 1611)	NC score	0.013141 (rank : 1633)
Query Neighborhood Hits	1762	Target Neighborhood Hits	98	Shared Neighborhood Hits	36
SwissProt Accessions	Q8IVT2	Gene names	C19orf21
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf21.

CSPG4_HUMAN
θ value	6.88961 (rank : 1612)	NC score	0.004918 (rank : 1767)
Query Neighborhood Hits	1762	Target Neighborhood Hits	112	Shared Neighborhood Hits	18
SwissProt Accessions	Q6UVK1, Q92675	Gene names	CSPG4, MCSP
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 4 precursor (Chondroitin sulfate proteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan) (Melanoma-associated chondroitin sulfate proteoglycan).

CTND2_MOUSE
θ value	6.88961 (rank : 1613)	NC score	0.007844 (rank : 1715)
Query Neighborhood Hits	1762	Target Neighborhood Hits	227	Shared Neighborhood Hits	74
SwissProt Accessions	O35927	Gene names	Ctnnd2, Catnd2, Nprap
Domain Architecture
Description	Catenin delta-2 (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin).

DDX46_HUMAN
θ value	6.88961 (rank : 1614)	NC score	-0.003278 (rank : 1878)
Query Neighborhood Hits	1762	Target Neighborhood Hits	357	Shared Neighborhood Hits	48
SwissProt Accessions	Q7L014, O94894, Q96EI0, Q9Y658	Gene names	DDX46, KIAA0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46) (PRP5 homolog).

DDX51_MOUSE
θ value	6.88961 (rank : 1615)	NC score	-0.007553 (rank : 1894)
Query Neighborhood Hits	1762	Target Neighborhood Hits	130	Shared Neighborhood Hits	17
SwissProt Accessions	Q6P9R1, Q3U7M2	Gene names	Ddx51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

ELF4_HUMAN
θ value	6.88961 (rank : 1616)	NC score	0.001252 (rank : 1828)
Query Neighborhood Hits	1762	Target Neighborhood Hits	87	Shared Neighborhood Hits	22
SwissProt Accessions	Q99607, O60435	Gene names	ELF4, ELFR, MEF
Domain Architecture	No domain graphic available
Description	ETS-related transcription factor Elf-4 (E74-like factor 4) (Myeloid Elf-1-like factor).

FCRLA_MOUSE
θ value	6.88961 (rank : 1617)	NC score	0.054645 (rank : 1291)
Query Neighborhood Hits	1762	Target Neighborhood Hits	110	Shared Neighborhood Hits	58
SwissProt Accessions	Q920A9, Q3T9Q2, Q8K3U9, Q8VHP5	Gene names	Fcrla, Fcrl, Fcrl1, Fcrlm1, Fcrx, Freb
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

FMN1A_MOUSE
θ value	6.88961 (rank : 1618)	NC score	0.029947 (rank : 1451)
Query Neighborhood Hits	1762	Target Neighborhood Hits	423	Shared Neighborhood Hits	166
SwissProt Accessions	Q05860	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoforms I/II/III (Limb deformity protein).

FMN1B_MOUSE
θ value	6.88961 (rank : 1619)	NC score	0.030803 (rank : 1445)
Query Neighborhood Hits	1762	Target Neighborhood Hits	447	Shared Neighborhood Hits	171
SwissProt Accessions	Q05859	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoform IV (Limb deformity protein).

GGN_MOUSE
θ value	6.88961 (rank : 1620)	NC score	0.052303 (rank : 1305)
Query Neighborhood Hits	1762	Target Neighborhood Hits	311	Shared Neighborhood Hits	160
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

GP137_HUMAN
θ value	6.88961 (rank : 1621)	NC score	0.012865 (rank : 1637)
Query Neighborhood Hits	1762	Target Neighborhood Hits	119	Shared Neighborhood Hits	29
SwissProt Accessions	Q14444, Q15074	Gene names	M11S1, GPIP137
Domain Architecture	No domain graphic available
Description	GPI-anchored protein p137 (p137GPI) (Membrane component chromosome 11 surface marker 1).

HCFC2_MOUSE
θ value	6.88961 (rank : 1622)	NC score	0.108053 (rank : 1106)
Query Neighborhood Hits	1762	Target Neighborhood Hits	97	Shared Neighborhood Hits	85
SwissProt Accessions	Q9D968	Gene names	Hcfc2
Domain Architecture	No domain graphic available
Description	Host cell factor 2 (HCF-2) (C2 factor).

IL3RB_MOUSE
θ value	6.88961 (rank : 1623)	NC score	0.015416 (rank : 1609)
Query Neighborhood Hits	1762	Target Neighborhood Hits	355	Shared Neighborhood Hits	99
SwissProt Accessions	P26955	Gene names	Csf2rb, Aic2b, Csf2rb1, Il3rb1
Domain Architecture
Description	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen).

ITAE_MOUSE
θ value	6.88961 (rank : 1624)	NC score	-0.006143 (rank : 1890)
Query Neighborhood Hits	1762	Target Neighborhood Hits	73	Shared Neighborhood Hits	5
SwissProt Accessions	Q60677	Gene names	Itgae
Domain Architecture
Description	Integrin alpha-E precursor (Integrin alpha M290) (CD103 antigen) [Contains: Integrin alpha-E light chain; Integrin alpha-E heavy chain].

K0226_HUMAN
θ value	6.88961 (rank : 1625)	NC score	0.004566 (rank : 1777)
Query Neighborhood Hits	1762	Target Neighborhood Hits	92	Shared Neighborhood Hits	26
SwissProt Accessions	Q92622	Gene names	KIAA0226
Domain Architecture	No domain graphic available
Description	Protein KIAA0226.

MAP2_HUMAN
θ value	6.88961 (rank : 1626)	NC score	0.017730 (rank : 1577)
Query Neighborhood Hits	1762	Target Neighborhood Hits	348	Shared Neighborhood Hits	96
SwissProt Accessions	P11137, Q99975, Q99976	Gene names	MAP2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2) (MAP-2).

MARCS_HUMAN
θ value	6.88961 (rank : 1627)	NC score	0.058075 (rank : 1268)
Query Neighborhood Hits	1762	Target Neighborhood Hits	204	Shared Neighborhood Hits	98
SwissProt Accessions	P29966, Q2LA83, Q5TDB7	Gene names	MARCKS, MACS, PRKCSL
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (PKCSL) (80K-L protein).

MEGF9_HUMAN
θ value	6.88961 (rank : 1628)	NC score	0.024130 (rank : 1504)
Query Neighborhood Hits	1762	Target Neighborhood Hits	557	Shared Neighborhood Hits	154
SwissProt Accessions	Q9H1U4, O75098	Gene names	MEGF9, EGFL5, KIAA0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

MICA1_HUMAN
θ value	6.88961 (rank : 1629)	NC score	0.003530 (rank : 1795)
Query Neighborhood Hits	1762	Target Neighborhood Hits	279	Shared Neighborhood Hits	69
SwissProt Accessions	Q8TDZ2, Q7Z633, Q8IVS9, Q96G47, Q9H6X6, Q9H7I0, Q9HAA1, Q9UFF7	Gene names	MICAL1, MICAL, NICAL
Domain Architecture
Description	NEDD9-interacting protein with calponin homology and LIM domains (Molecule interacting with CasL protein 1).

MINT_HUMAN
θ value	6.88961 (rank : 1630)	NC score	0.043676 (rank : 1350)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1291	Shared Neighborhood Hits	305
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

MKL2_HUMAN
θ value	6.88961 (rank : 1631)	NC score	0.018875 (rank : 1563)
Query Neighborhood Hits	1762	Target Neighborhood Hits	274	Shared Neighborhood Hits	86
SwissProt Accessions	Q9ULH7, Q68CT1, Q6UB16, Q86WW2, Q8N226	Gene names	MKL2, KIAA1243, MRTFB
Domain Architecture
Description	MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B) (Megakaryoblastic leukemia 2).

MLL2_HUMAN
θ value	6.88961 (rank : 1632)	NC score	0.054923 (rank : 1287)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1788	Shared Neighborhood Hits	435
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

MPP2_MOUSE
θ value	6.88961 (rank : 1633)	NC score	0.021959 (rank : 1523)
Query Neighborhood Hits	1762	Target Neighborhood Hits	189	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

MTG8R_HUMAN
θ value	6.88961 (rank : 1634)	NC score	0.001477 (rank : 1823)
Query Neighborhood Hits	1762	Target Neighborhood Hits	125	Shared Neighborhood Hits	31
SwissProt Accessions	O43439, Q5TGE4, Q5TGE7, Q8IWF3, Q96B06, Q96L00, Q9H436, Q9UJP8, Q9UJP9, Q9UP24	Gene names	CBFA2T2, EHT, MTGR1
Domain Architecture
Description	Protein CBFA2T2 (MTG8-like protein) (MTG8-related protein 1) (Myeloid translocation-related protein 1) (ETO homologous on chromosome 20) (p85).

NASP_HUMAN
θ value	6.88961 (rank : 1635)	NC score	0.013410 (rank : 1627)
Query Neighborhood Hits	1762	Target Neighborhood Hits	709	Shared Neighborhood Hits	101
SwissProt Accessions	P49321, Q96A69, Q9BTW2	Gene names	NASP
Domain Architecture
Description	Nuclear autoantigenic sperm protein (NASP).

NFAM1_HUMAN
θ value	6.88961 (rank : 1636)	NC score	0.003639 (rank : 1793)
Query Neighborhood Hits	1762	Target Neighborhood Hits	14	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NET5, Q8IUY8, Q8TEM8	Gene names	NFAM1, CNAIP
Domain Architecture	No domain graphic available
Description	NFAT activation molecule 1 precursor (Calcineurin/NFAT-activating ITAM-containing protein) (NFAT-activating protein with ITAM motif 1).

PCBP4_MOUSE
θ value	6.88961 (rank : 1637)	NC score	-0.000037 (rank : 1844)
Query Neighborhood Hits	1762	Target Neighborhood Hits	46	Shared Neighborhood Hits	10
SwissProt Accessions	P57724, Q91VR3	Gene names	Pcbp4
Domain Architecture
Description	Poly(rC)-binding protein 4 (Alpha-CP4).

PCIF1_HUMAN
θ value	6.88961 (rank : 1638)	NC score	0.006305 (rank : 1742)
Query Neighborhood Hits	1762	Target Neighborhood Hits	92	Shared Neighborhood Hits	29
SwissProt Accessions	Q9H4Z3, Q9NT85	Gene names	PCIF1, C20orf67
Domain Architecture
Description	Phosphorylated CTD-interacting factor 1.

PCX3_MOUSE
θ value	6.88961 (rank : 1639)	NC score	0.018063 (rank : 1569)
Query Neighborhood Hits	1762	Target Neighborhood Hits	134	Shared Neighborhood Hits	61
SwissProt Accessions	Q8VI59	Gene names	Pcnxl3
Domain Architecture
Description	Pecanex-like protein 3.

PDCD7_MOUSE
θ value	6.88961 (rank : 1640)	NC score	0.023010 (rank : 1517)
Query Neighborhood Hits	1762	Target Neighborhood Hits	214	Shared Neighborhood Hits	75
SwissProt Accessions	Q9WTY1, Q8R5D9	Gene names	Pdcd7
Domain Architecture	No domain graphic available
Description	Programmed cell death protein 7 (ES18).

PDLI7_MOUSE
θ value	6.88961 (rank : 1641)	NC score	0.003620 (rank : 1794)
Query Neighborhood Hits	1762	Target Neighborhood Hits	279	Shared Neighborhood Hits	40
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PRG4_HUMAN
θ value	6.88961 (rank : 1642)	NC score	0.077213 (rank : 1167)
Query Neighborhood Hits	1762	Target Neighborhood Hits	764	Shared Neighborhood Hits	286
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PRP1_HUMAN
θ value	6.88961 (rank : 1643)	NC score	0.084290 (rank : 1147)
Query Neighborhood Hits	1762	Target Neighborhood Hits	385	Shared Neighborhood Hits	193
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

PS1C2_MOUSE
θ value	6.88961 (rank : 1644)	NC score	0.034784 (rank : 1414)
Query Neighborhood Hits	1762	Target Neighborhood Hits	59	Shared Neighborhood Hits	32
SwissProt Accessions	Q80ZC9	Gene names	Psors1c2, Spr1
Domain Architecture	No domain graphic available
Description	Psoriasis susceptibility 1 candidate gene 2 protein homolog precursor (SPR1 protein).

PSG5_HUMAN
θ value	6.88961 (rank : 1645)	NC score	0.150148 (rank : 1054)
Query Neighborhood Hits	1762	Target Neighborhood Hits	231	Shared Neighborhood Hits	182
SwissProt Accessions	Q15238, Q15239, Q96QJ1, Q9UQ75	Gene names	PSG5
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 5 precursor (PSBG-5) (Fetal liver non-specific cross-reactive antigen 3) (FL-NCA-3).

RAI1_HUMAN
θ value	6.88961 (rank : 1646)	NC score	0.017435 (rank : 1584)
Query Neighborhood Hits	1762	Target Neighborhood Hits	360	Shared Neighborhood Hits	120
SwissProt Accessions	Q7Z5J4, Q8N3B4, Q8ND08, Q8WU64, Q96JK5, Q9H1C1, Q9H1C2, Q9UF69	Gene names	RAI1, KIAA1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

RAPH1_HUMAN
θ value	6.88961 (rank : 1647)	NC score	0.054118 (rank : 1294)
Query Neighborhood Hits	1762	Target Neighborhood Hits	593	Shared Neighborhood Hits	246
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

RASL1_HUMAN
θ value	6.88961 (rank : 1648)	NC score	0.025280 (rank : 1493)
Query Neighborhood Hits	1762	Target Neighborhood Hits	142	Shared Neighborhood Hits	28
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

SFR16_MOUSE
θ value	6.88961 (rank : 1649)	NC score	0.026456 (rank : 1486)
Query Neighborhood Hits	1762	Target Neighborhood Hits	177	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CFC7, Q8CFC8, Q9Z2N3	Gene names	Sfrs16, Clasp, Swap2
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 16 (Suppressor of white-apricot homolog 2) (Clk4-associating SR-related protein).

SKI_HUMAN
θ value	6.88961 (rank : 1650)	NC score	0.010801 (rank : 1673)
Query Neighborhood Hits	1762	Target Neighborhood Hits	423	Shared Neighborhood Hits	48
SwissProt Accessions	P12755, Q5SYT7	Gene names	SKI
Domain Architecture
Description	Ski oncogene (C-ski).

SMAL1_HUMAN
θ value	6.88961 (rank : 1651)	NC score	0.000198 (rank : 1842)
Query Neighborhood Hits	1762	Target Neighborhood Hits	174	Shared Neighborhood Hits	49
SwissProt Accessions	Q9NZC9, Q96AY1, Q9NXQ5, Q9UFH3, Q9UI93	Gene names	SMARCAL1, HARP
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (hHARP).

SOX6_MOUSE
θ value	6.88961 (rank : 1652)	NC score	0.009592 (rank : 1688)
Query Neighborhood Hits	1762	Target Neighborhood Hits	341	Shared Neighborhood Hits	58
SwissProt Accessions	P40645, Q62250, Q9QWS5	Gene names	Sox6, Sox-6
Domain Architecture
Description	Transcription factor SOX-6 (SOX-LZ).

SPT5H_HUMAN
θ value	6.88961 (rank : 1653)	NC score	0.023338 (rank : 1513)
Query Neighborhood Hits	1762	Target Neighborhood Hits	436	Shared Neighborhood Hits	146
SwissProt Accessions	O00267, O43279, Q59G52, Q99639	Gene names	SUPT5H, SPT5, SPT5H
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (DSIF p160) (Tat- cotransactivator 1 protein) (Tat-CT1 protein).

SPT5H_MOUSE
θ value	6.88961 (rank : 1654)	NC score	0.023368 (rank : 1512)
Query Neighborhood Hits	1762	Target Neighborhood Hits	437	Shared Neighborhood Hits	146
SwissProt Accessions	O55201, Q3UJ77, Q3UJH1, Q3UKD7, Q3UM54, Q6PB73, Q6PDP0, Q6PFR4	Gene names	Supt5h
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit).

SYN1_HUMAN
θ value	6.88961 (rank : 1655)	NC score	0.050074 (rank : 1322)
Query Neighborhood Hits	1762	Target Neighborhood Hits	419	Shared Neighborhood Hits	217
SwissProt Accessions	P17600, O75825, Q5H9A9	Gene names	SYN1
Domain Architecture
Description	Synapsin-1 (Synapsin I) (Brain protein 4.1).

TJAP1_MOUSE
θ value	6.88961 (rank : 1656)	NC score	0.013818 (rank : 1623)
Query Neighborhood Hits	1762	Target Neighborhood Hits	295	Shared Neighborhood Hits	41
SwissProt Accessions	Q9DCD5, Q8CFL7, Q8R5I2	Gene names	Tjap1, Pilt, Tjp4
Domain Architecture	No domain graphic available
Description	Tight junction-associated protein 1 (Tight junction protein 4) (Protein incorporated later into tight junctions).

UBP6_HUMAN
θ value	6.88961 (rank : 1657)	NC score	-0.003307 (rank : 1879)
Query Neighborhood Hits	1762	Target Neighborhood Hits	188	Shared Neighborhood Hits	33
SwissProt Accessions	P35125, Q15634, Q86WP6, Q8IWT4	Gene names	USP6, TRE2
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.1.2.15) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6) (Deubiquitinating enzyme 6) (Proto-oncogene TRE-2).

UBXD2_HUMAN
θ value	6.88961 (rank : 1658)	NC score	0.012047 (rank : 1655)
Query Neighborhood Hits	1762	Target Neighborhood Hits	241	Shared Neighborhood Hits	29
SwissProt Accessions	Q92575, Q8IYM5	Gene names	UBXD2, KIAA0242, UBXDC1
Domain Architecture
Description	UBX domain-containing protein 2.

WASF3_MOUSE
θ value	6.88961 (rank : 1659)	NC score	0.021664 (rank : 1529)
Query Neighborhood Hits	1762	Target Neighborhood Hits	188	Shared Neighborhood Hits	99
SwissProt Accessions	Q8VHI6	Gene names	Wasf3, Wave3
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 3 (WASP-family protein member 3) (Protein WAVE-3).

WFDC1_MOUSE
θ value	6.88961 (rank : 1660)	NC score	0.001853 (rank : 1818)
Query Neighborhood Hits	1762	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ESH5, Q8R110	Gene names	Wfdc1, Ps20
Domain Architecture	No domain graphic available
Description	WAP four-disulfide core domain protein 1 precursor (Prostate stromal protein ps20) (ps20 growth inhibitor).

WFS1_HUMAN
θ value	6.88961 (rank : 1661)	NC score	0.005898 (rank : 1747)
Query Neighborhood Hits	1762	Target Neighborhood Hits	42	Shared Neighborhood Hits	18
SwissProt Accessions	O76024, Q8N6I3, Q9UNW6	Gene names	WFS1
Domain Architecture	No domain graphic available
Description	Wolframin.

ZDHC8_HUMAN
θ value	6.88961 (rank : 1662)	NC score	0.002151 (rank : 1814)
Query Neighborhood Hits	1762	Target Neighborhood Hits	234	Shared Neighborhood Hits	71
SwissProt Accessions	Q9ULC8, Q6ICL1, Q6ZNF5, Q7Z6L9	Gene names	ZDHHC8, KIAA1292, ZDHHCL1, ZNF378
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC8 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378).

ZFY28_HUMAN
θ value	6.88961 (rank : 1663)	NC score	-0.004706 (rank : 1886)
Query Neighborhood Hits	1762	Target Neighborhood Hits	152	Shared Neighborhood Hits	20
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZN219_HUMAN
θ value	6.88961 (rank : 1664)	NC score	-0.020225 (rank : 1918)
Query Neighborhood Hits	1762	Target Neighborhood Hits	876	Shared Neighborhood Hits	128
SwissProt Accessions	Q9P2Y4, Q8IYC1, Q9BW28	Gene names	ZNF219
Domain Architecture	No domain graphic available
Description	Zinc finger protein 219.

3BP2_MOUSE
θ value	8.99809 (rank : 1665)	NC score	0.020643 (rank : 1540)
Query Neighborhood Hits	1762	Target Neighborhood Hits	142	Shared Neighborhood Hits	51
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

AB1IP_MOUSE
θ value	8.99809 (rank : 1666)	NC score	0.017048 (rank : 1590)
Query Neighborhood Hits	1762	Target Neighborhood Hits	181	Shared Neighborhood Hits	83
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

ABCA7_HUMAN
θ value	8.99809 (rank : 1667)	NC score	-0.006927 (rank : 1891)
Query Neighborhood Hits	1762	Target Neighborhood Hits	144	Shared Neighborhood Hits	18
SwissProt Accessions	Q8IZY2, Q96S58, Q9BZC4, Q9NR73, Q9UKP8	Gene names	ABCA7
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 7 (Macrophage ABC transporter) (Autoantigen SS-N) (ABCA-SSN).

AKIP_HUMAN
θ value	8.99809 (rank : 1668)	NC score	0.002256 (rank : 1812)
Query Neighborhood Hits	1762	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NWT8, Q5TA36, Q8TBD3	Gene names	AURKAIP1, AIP, AKIP
Domain Architecture	No domain graphic available
Description	Aurora kinase A-interacting protein (AURKA-interacting protein).

AMGO3_HUMAN
θ value	8.99809 (rank : 1669)	NC score	0.045022 (rank : 1345)
Query Neighborhood Hits	1762	Target Neighborhood Hits	276	Shared Neighborhood Hits	83
SwissProt Accessions	Q86WK7, Q96JH6	Gene names	AMIGO3, ALI3, KIAA1851
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 3 precursor (AMIGO-3) (Alivin-3).

ANK1_HUMAN
θ value	8.99809 (rank : 1670)	NC score	0.005761 (rank : 1752)
Query Neighborhood Hits	1762	Target Neighborhood Hits	416	Shared Neighborhood Hits	54
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

BAG3_HUMAN
θ value	8.99809 (rank : 1671)	NC score	0.033724 (rank : 1422)
Query Neighborhood Hits	1762	Target Neighborhood Hits	314	Shared Neighborhood Hits	129
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

BAG3_MOUSE
θ value	8.99809 (rank : 1672)	NC score	0.033367 (rank : 1423)
Query Neighborhood Hits	1762	Target Neighborhood Hits	513	Shared Neighborhood Hits	185
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

BAT3_HUMAN
θ value	8.99809 (rank : 1673)	NC score	0.026218 (rank : 1487)
Query Neighborhood Hits	1762	Target Neighborhood Hits	490	Shared Neighborhood Hits	169
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

BAT3_MOUSE
θ value	8.99809 (rank : 1674)	NC score	0.028080 (rank : 1466)
Query Neighborhood Hits	1762	Target Neighborhood Hits	518	Shared Neighborhood Hits	177
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

CABIN_HUMAN
θ value	8.99809 (rank : 1675)	NC score	0.039382 (rank : 1382)
Query Neighborhood Hits	1762	Target Neighborhood Hits	490	Shared Neighborhood Hits	183
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

CALX_HUMAN
θ value	8.99809 (rank : 1676)	NC score	0.003425 (rank : 1798)
Query Neighborhood Hits	1762	Target Neighborhood Hits	96	Shared Neighborhood Hits	23
SwissProt Accessions	P27824	Gene names	CANX
Domain Architecture
Description	Calnexin precursor (Major histocompatibility complex class I antigen- binding protein p88) (p90) (IP90).

CDC73_HUMAN
θ value	8.99809 (rank : 1677)	NC score	0.005541 (rank : 1757)
Query Neighborhood Hits	1762	Target Neighborhood Hits	38	Shared Neighborhood Hits	15
SwissProt Accessions	Q6P1J9, Q6PK51, Q96A07, Q9H245, Q9H5L7	Gene names	CDC73, C1orf28, HRPT2
Domain Architecture	No domain graphic available
Description	Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein).

CDC73_MOUSE
θ value	8.99809 (rank : 1678)	NC score	0.005541 (rank : 1758)
Query Neighborhood Hits	1762	Target Neighborhood Hits	38	Shared Neighborhood Hits	15
SwissProt Accessions	Q8JZM7	Gene names	Cdc73
Domain Architecture	No domain graphic available
Description	Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein homolog).

CI037_HUMAN
θ value	8.99809 (rank : 1679)	NC score	0.005310 (rank : 1763)
Query Neighborhood Hits	1762	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H2J1, Q5T368	Gene names	C9orf37
Domain Architecture	No domain graphic available
Description	Protein C9orf37.

CIR_MOUSE
θ value	8.99809 (rank : 1680)	NC score	0.012032 (rank : 1656)
Query Neighborhood Hits	1762	Target Neighborhood Hits	255	Shared Neighborhood Hits	38
SwissProt Accessions	Q9DA19, Q3V2N9, Q4KL44, Q52KL9, Q5FW66	Gene names	Cir
Domain Architecture	No domain graphic available
Description	CBF1-interacting corepressor.

CJ078_MOUSE
θ value	8.99809 (rank : 1681)	NC score	0.060339 (rank : 1249)
Query Neighborhood Hits	1762	Target Neighborhood Hits	559	Shared Neighborhood Hits	204
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

CO3A1_HUMAN
θ value	8.99809 (rank : 1682)	NC score	0.013367 (rank : 1629)
Query Neighborhood Hits	1762	Target Neighborhood Hits	452	Shared Neighborhood Hits	145
SwissProt Accessions	P02461, Q15112, Q16403, Q6LDB3, Q6LDJ2, Q6LDJ3, Q7KZ56	Gene names	COL3A1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

COFA1_HUMAN
θ value	8.99809 (rank : 1683)	NC score	0.006240 (rank : 1743)
Query Neighborhood Hits	1762	Target Neighborhood Hits	292	Shared Neighborhood Hits	95
SwissProt Accessions	P39059, Q5T6J4, Q9Y4W4	Gene names	COL15A1
Domain Architecture
Description	Collagen alpha-1(XV) chain precursor [Contains: Endostatin (Endostatin-XV) (Restin) (Related to endostatin)].

CRTC1_HUMAN
θ value	8.99809 (rank : 1684)	NC score	0.032221 (rank : 1434)
Query Neighborhood Hits	1762	Target Neighborhood Hits	319	Shared Neighborhood Hits	140
SwissProt Accessions	Q6UUV9, O75114, Q6Y3A3, Q7LDZ2, Q8IUL3, Q8IZ34, Q8IZL1, Q8N6W3, Q96AI8, Q9H801	Gene names	CRTC1, KIAA0616, MECT1, TORC1, WAMTP1
Domain Architecture	No domain graphic available
Description	CREB-regulated transcription coactivator 1 (Transducer of regulated cAMP response element-binding protein 1) (Transducer of CREB protein 1) (Mucoepidermoid carcinoma translocated protein 1).

CSKI1_HUMAN
θ value	8.99809 (rank : 1685)	NC score	0.046709 (rank : 1341)
Query Neighborhood Hits	1762	Target Neighborhood Hits	997	Shared Neighborhood Hits	318
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

DBPA_MOUSE
θ value	8.99809 (rank : 1686)	NC score	0.007089 (rank : 1733)
Query Neighborhood Hits	1762	Target Neighborhood Hits	64	Shared Neighborhood Hits	25
SwissProt Accessions	Q9JKB3, Q80WG4, Q9EQF7, Q9EQF8	Gene names	Csda, Msy4, Ybx3
Domain Architecture	No domain graphic available
Description	DNA-binding protein A (Cold shock domain-containing protein A) (Y-box protein 3).

DDEF2_MOUSE
θ value	8.99809 (rank : 1687)	NC score	0.007379 (rank : 1724)
Query Neighborhood Hits	1762	Target Neighborhood Hits	625	Shared Neighborhood Hits	137
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DIPA_HUMAN
θ value	8.99809 (rank : 1688)	NC score	0.002664 (rank : 1806)
Query Neighborhood Hits	1762	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q15834, Q96HA0	Gene names	CCDC85B, DIPA
Domain Architecture	No domain graphic available
Description	Delta-interacting protein A (Hepatitis delta antigen-interacting protein A) (Coiled-coil domain-containing protein 85B).

DIPA_MOUSE
θ value	8.99809 (rank : 1689)	NC score	0.002764 (rank : 1805)
Query Neighborhood Hits	1762	Target Neighborhood Hits	25	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PDY0	Gene names	Ccdc85b, Dipa
Domain Architecture	No domain graphic available
Description	Delta-interacting protein A homolog (Coiled-coil domain-containing protein 85B).

EMIL2_HUMAN
θ value	8.99809 (rank : 1690)	NC score	0.000408 (rank : 1841)
Query Neighborhood Hits	1762	Target Neighborhood Hits	573	Shared Neighborhood Hits	96
SwissProt Accessions	Q9BXX0, Q8NBH3, Q96JQ4	Gene names	EMILIN2
Domain Architecture
Description	EMILIN-2 precursor (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2) (Protein FOAP-10).

ENSA_MOUSE
θ value	8.99809 (rank : 1691)	NC score	0.004105 (rank : 1782)
Query Neighborhood Hits	1762	Target Neighborhood Hits	10	Shared Neighborhood Hits	5
SwissProt Accessions	P60840, Q9CQZ9, Q9Z0G1	Gene names	Ensa
Domain Architecture
Description	Alpha-endosulfine (ARPP-19e).

EP400_MOUSE
θ value	8.99809 (rank : 1692)	NC score	0.018277 (rank : 1567)
Query Neighborhood Hits	1762	Target Neighborhood Hits	592	Shared Neighborhood Hits	207
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

EPIPL_HUMAN
θ value	8.99809 (rank : 1693)	NC score	-0.000971 (rank : 1854)
Query Neighborhood Hits	1762	Target Neighborhood Hits	73	Shared Neighborhood Hits	10
SwissProt Accessions	P58107, Q76E58	Gene names	EPPK1, EPIPL
Domain Architecture
Description	Epiplakin (450 kDa epidermal antigen).

ETV5_HUMAN
θ value	8.99809 (rank : 1694)	NC score	0.001247 (rank : 1829)
Query Neighborhood Hits	1762	Target Neighborhood Hits	181	Shared Neighborhood Hits	57
SwissProt Accessions	P41161	Gene names	ETV5, ERM
Domain Architecture
Description	ETS translocation variant 5 (Ets-related protein ERM).

EVI2B_HUMAN
θ value	8.99809 (rank : 1695)	NC score	0.010900 (rank : 1672)
Query Neighborhood Hits	1762	Target Neighborhood Hits	135	Shared Neighborhood Hits	47
SwissProt Accessions	P34910	Gene names	EVI2B, EVDB
Domain Architecture	No domain graphic available
Description	EVI2B protein precursor (Ecotropic viral integration site 2B protein).

EVL_HUMAN
θ value	8.99809 (rank : 1696)	NC score	0.022106 (rank : 1521)
Query Neighborhood Hits	1762	Target Neighborhood Hits	260	Shared Neighborhood Hits	112
SwissProt Accessions	Q9UI08, O95884, Q7Z522, Q8TBV1, Q9UF25, Q9UIC2	Gene names	EVL, RNB6
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

EVL_MOUSE
θ value	8.99809 (rank : 1697)	NC score	0.015058 (rank : 1613)
Query Neighborhood Hits	1762	Target Neighborhood Hits	203	Shared Neighborhood Hits	83
SwissProt Accessions	P70429, Q9ERU8	Gene names	Evl
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

FOXO4_HUMAN
θ value	8.99809 (rank : 1698)	NC score	-0.003583 (rank : 1881)
Query Neighborhood Hits	1762	Target Neighborhood Hits	197	Shared Neighborhood Hits	54
SwissProt Accessions	P98177, O43821, Q13720, Q3KPF1, Q8TDK9	Gene names	MLLT7, AFX, AFX1, FOXO4
Domain Architecture
Description	Fork head domain transcription factor AFX1 (Forkhead box protein O4).

GAK7_HUMAN
θ value	8.99809 (rank : 1699)	NC score	0.009171 (rank : 1694)
Query Neighborhood Hits	1762	Target Neighborhood Hits	90	Shared Neighborhood Hits	37
SwissProt Accessions	Q96PI4, Q9QC08	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q23.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K18 Gag protein) (HERV-K110 Gag protein) (HERV-K(C1a) Gag protein) [Contains: Matrix protein].

GGA1_HUMAN
θ value	8.99809 (rank : 1700)	NC score	0.006740 (rank : 1736)
Query Neighborhood Hits	1762	Target Neighborhood Hits	169	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UJY5, Q5TG07, Q9BW94, Q9UG00, Q9UGW0, Q9UGW1	Gene names	GGA1
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein 1).

GLI3_MOUSE
θ value	8.99809 (rank : 1701)	NC score	-0.026163 (rank : 1934)
Query Neighborhood Hits	1762	Target Neighborhood Hits	807	Shared Neighborhood Hits	61
SwissProt Accessions	Q61602	Gene names	Gli3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI3.

GP137_MOUSE
θ value	8.99809 (rank : 1702)	NC score	0.007814 (rank : 1716)
Query Neighborhood Hits	1762	Target Neighborhood Hits	102	Shared Neighborhood Hits	20
SwissProt Accessions	Q60865, Q60758, Q61620	Gene names	M11s1, Gpiap, Gpiap1, Gpip137
Domain Architecture	No domain graphic available
Description	GPI-anchored protein p137 (p137GPI).

GP152_HUMAN
θ value	8.99809 (rank : 1703)	NC score	-0.000835 (rank : 1852)
Query Neighborhood Hits	1762	Target Neighborhood Hits	636	Shared Neighborhood Hits	137
SwissProt Accessions	Q8TDT2, Q86SM0	Gene names	GPR152, PGR5
Domain Architecture
Description	Probable G-protein coupled receptor 152 (G-protein coupled receptor PGR5).

HSF1_HUMAN
θ value	8.99809 (rank : 1704)	NC score	0.011489 (rank : 1666)
Query Neighborhood Hits	1762	Target Neighborhood Hits	163	Shared Neighborhood Hits	56
SwissProt Accessions	Q00613	Gene names	HSF1, HSTF1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

HXB2_MOUSE
θ value	8.99809 (rank : 1705)	NC score	-0.015848 (rank : 1912)
Query Neighborhood Hits	1762	Target Neighborhood Hits	350	Shared Neighborhood Hits	25
SwissProt Accessions	P0C1T1	Gene names	Hoxb2, Hox-2.8
Domain Architecture	No domain graphic available
Description	Homeobox protein Hox-B2 (Hox-2.8).

ICAM3_HUMAN
θ value	8.99809 (rank : 1706)	NC score	0.069465 (rank : 1206)
Query Neighborhood Hits	1762	Target Neighborhood Hits	100	Shared Neighborhood Hits	82
SwissProt Accessions	P32942	Gene names	ICAM3
Domain Architecture
Description	Intercellular adhesion molecule 3 precursor (ICAM-3) (ICAM-R) (CDw50) (CD50 antigen).

INADL_HUMAN
θ value	8.99809 (rank : 1707)	NC score	-0.000765 (rank : 1851)
Query Neighborhood Hits	1762	Target Neighborhood Hits	260	Shared Neighborhood Hits	36
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

IQEC2_MOUSE
θ value	8.99809 (rank : 1708)	NC score	0.017147 (rank : 1588)
Query Neighborhood Hits	1762	Target Neighborhood Hits	417	Shared Neighborhood Hits	156
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

K0319_HUMAN
θ value	8.99809 (rank : 1709)	NC score	0.016353 (rank : 1598)
Query Neighborhood Hits	1762	Target Neighborhood Hits	154	Shared Neighborhood Hits	44
SwissProt Accessions	Q5VV43, Q9UJC8, Q9Y4G7	Gene names	KIAA0319
Domain Architecture	No domain graphic available
Description	Protein KIAA0319 precursor.

KCNQ1_MOUSE
θ value	8.99809 (rank : 1710)	NC score	-0.001803 (rank : 1865)
Query Neighborhood Hits	1762	Target Neighborhood Hits	175	Shared Neighborhood Hits	39
SwissProt Accessions	P97414, O88702, Q7TNZ1, Q7TPL7, Q80VR7	Gene names	Kcnq1, Kcna9, Kvlqt1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

LEG9_MOUSE
θ value	8.99809 (rank : 1711)	NC score	-0.002676 (rank : 1869)
Query Neighborhood Hits	1762	Target Neighborhood Hits	27	Shared Neighborhood Hits	5
SwissProt Accessions	O08573, O08572	Gene names	Lgals9
Domain Architecture
Description	Galectin-9.

LTBP3_MOUSE
θ value	8.99809 (rank : 1712)	NC score	-0.002843 (rank : 1872)
Query Neighborhood Hits	1762	Target Neighborhood Hits	475	Shared Neighborhood Hits	61
SwissProt Accessions	Q61810, Q8BNQ6	Gene names	Ltbp3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

MBD2_HUMAN
θ value	8.99809 (rank : 1713)	NC score	-0.001371 (rank : 1862)
Query Neighborhood Hits	1762	Target Neighborhood Hits	46	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UBB5, O95242, Q9UIS8	Gene names	MBD2
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 2 (Methyl-CpG-binding protein MBD2) (Demethylase) (DMTase).

MEF2A_HUMAN
θ value	8.99809 (rank : 1714)	NC score	0.005713 (rank : 1753)
Query Neighborhood Hits	1762	Target Neighborhood Hits	69	Shared Neighborhood Hits	28
SwissProt Accessions	Q02078, O43814, Q14223, Q14224, Q96D14	Gene names	MEF2A, MEF2
Domain Architecture
Description	Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1).

MEF2B_MOUSE
θ value	8.99809 (rank : 1715)	NC score	0.003930 (rank : 1786)
Query Neighborhood Hits	1762	Target Neighborhood Hits	218	Shared Neighborhood Hits	63
SwissProt Accessions	O55087, O55088, O55089, O55090, O55231, Q61843	Gene names	Mef2b
Domain Architecture
Description	Myocyte-specific enhancer factor 2B.

MN1_HUMAN
θ value	8.99809 (rank : 1716)	NC score	0.020868 (rank : 1536)
Query Neighborhood Hits	1762	Target Neighborhood Hits	196	Shared Neighborhood Hits	80
SwissProt Accessions	Q10571	Gene names	MN1
Domain Architecture	No domain graphic available
Description	Probable tumor suppressor protein MN1.

MRIP_MOUSE
θ value	8.99809 (rank : 1717)	NC score	0.015675 (rank : 1604)
Query Neighborhood Hits	1762	Target Neighborhood Hits	569	Shared Neighborhood Hits	64
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

MUCDL_MOUSE
θ value	8.99809 (rank : 1718)	NC score	0.018543 (rank : 1565)
Query Neighborhood Hits	1762	Target Neighborhood Hits	461	Shared Neighborhood Hits	137
SwissProt Accessions	Q8VHF2, Q8CEJ3, Q9D8I9	Gene names	Mucdhl
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

MYCL1_HUMAN
θ value	8.99809 (rank : 1719)	NC score	-0.002087 (rank : 1867)
Query Neighborhood Hits	1762	Target Neighborhood Hits	146	Shared Neighborhood Hits	31
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

NUCL_HUMAN
θ value	8.99809 (rank : 1720)	NC score	-0.003212 (rank : 1877)
Query Neighborhood Hits	1762	Target Neighborhood Hits	415	Shared Neighborhood Hits	53
SwissProt Accessions	P19338, Q53SK1, Q8NB06	Gene names	NCL
Domain Architecture
Description	Nucleolin (Protein C23).

NUP98_HUMAN
θ value	8.99809 (rank : 1721)	NC score	0.005322 (rank : 1762)
Query Neighborhood Hits	1762	Target Neighborhood Hits	81	Shared Neighborhood Hits	24
SwissProt Accessions	P52948, Q8IUT2, Q8WYB0, Q96E54, Q9H3Q4, Q9NT02, Q9UF57, Q9UHX0, Q9Y6J4, Q9Y6J5	Gene names	NUP98
Domain Architecture
Description	Nuclear pore complex protein Nup98-Nup96 precursor [Contains: Nuclear pore complex protein Nup98 (Nucleoporin Nup98) (98 kDa nucleoporin); Nuclear pore complex protein Nup96 (Nucleoporin Nup96) (96 kDa nucleoporin)].

OLR1_MOUSE
θ value	8.99809 (rank : 1722)	NC score	-0.002142 (rank : 1868)
Query Neighborhood Hits	1762	Target Neighborhood Hits	596	Shared Neighborhood Hits	42
SwissProt Accessions	Q9EQ09	Gene names	Olr1, Lox1
Domain Architecture	No domain graphic available
Description	Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) (Lectin-type oxidized LDL receptor 1) (Lectin-like oxidized LDL receptor 1) (Lectin-like oxLDL receptor 1) (LOX-1) [Contains: Oxidized low-density lipoprotein receptor 1, soluble form].

PAR10_HUMAN
θ value	8.99809 (rank : 1723)	NC score	0.002100 (rank : 1815)
Query Neighborhood Hits	1762	Target Neighborhood Hits	142	Shared Neighborhood Hits	32
SwissProt Accessions	Q53GL7, Q8N2I0, Q8WV05, Q96CH7	Gene names	PARP10
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 10 (EC 2.4.2.30) (PARP-10).

PCGF2_HUMAN
θ value	8.99809 (rank : 1724)	NC score	-0.001148 (rank : 1856)
Query Neighborhood Hits	1762	Target Neighborhood Hits	222	Shared Neighborhood Hits	37
SwissProt Accessions	P35227	Gene names	PCGF2, MEL18, RNF110, ZNF144
Domain Architecture
Description	Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144).

PCOC1_HUMAN
θ value	8.99809 (rank : 1725)	NC score	-0.004967 (rank : 1887)
Query Neighborhood Hits	1762	Target Neighborhood Hits	146	Shared Neighborhood Hits	30
SwissProt Accessions	Q15113, O14550	Gene names	PCOLCE, PCPE1
Domain Architecture
Description	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein).

PDCD7_HUMAN
θ value	8.99809 (rank : 1726)	NC score	0.022050 (rank : 1522)
Query Neighborhood Hits	1762	Target Neighborhood Hits	255	Shared Neighborhood Hits	80
SwissProt Accessions	Q8N8D1, Q96AK8, Q9Y6D7	Gene names	PDCD7
Domain Architecture	No domain graphic available
Description	Programmed cell death protein 7 (ES18) (HES18).

PER2_MOUSE
θ value	8.99809 (rank : 1727)	NC score	0.009170 (rank : 1695)
Query Neighborhood Hits	1762	Target Neighborhood Hits	325	Shared Neighborhood Hits	91
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

PGCA_HUMAN
θ value	8.99809 (rank : 1728)	NC score	0.008084 (rank : 1713)
Query Neighborhood Hits	1762	Target Neighborhood Hits	821	Shared Neighborhood Hits	188
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

PGCA_MOUSE
θ value	8.99809 (rank : 1729)	NC score	0.008433 (rank : 1708)
Query Neighborhood Hits	1762	Target Neighborhood Hits	643	Shared Neighborhood Hits	134
SwissProt Accessions	Q61282, Q64021	Gene names	Agc1, Agc
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP).

PHLPP_MOUSE
θ value	8.99809 (rank : 1730)	NC score	0.019297 (rank : 1556)
Query Neighborhood Hits	1762	Target Neighborhood Hits	394	Shared Neighborhood Hits	91
SwissProt Accessions	Q8CHE4, Q6PCN0, Q8QZU8, Q8R5E5, Q99KL6	Gene names	Phlpp, Kiaa0606, Plekhe1, Scop
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein).

POGZ_HUMAN
θ value	8.99809 (rank : 1731)	NC score	-0.022901 (rank : 1922)
Query Neighborhood Hits	1762	Target Neighborhood Hits	745	Shared Neighborhood Hits	60
SwissProt Accessions	Q7Z3K3, O75049, Q8TDZ7, Q9Y4X7	Gene names	POGZ, KIAA0461
Domain Architecture
Description	Pogo transposable element with ZNF domain.

PRAX_HUMAN
θ value	8.99809 (rank : 1732)	NC score	0.037257 (rank : 1399)
Query Neighborhood Hits	1762	Target Neighborhood Hits	215	Shared Neighborhood Hits	72
SwissProt Accessions	Q9BXM0, Q9BXL9, Q9HCF2	Gene names	PRX, KIAA1620
Domain Architecture
Description	Periaxin.

PRG4_MOUSE
θ value	8.99809 (rank : 1733)	NC score	0.070142 (rank : 1205)
Query Neighborhood Hits	1762	Target Neighborhood Hits	624	Shared Neighborhood Hits	233
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PRGC2_HUMAN
θ value	8.99809 (rank : 1734)	NC score	0.012727 (rank : 1639)
Query Neighborhood Hits	1762	Target Neighborhood Hits	272	Shared Neighborhood Hits	74
SwissProt Accessions	Q86YN6, Q86YN3, Q86YN4, Q86YN5, Q8N1N9, Q8TDE4, Q8TDE5	Gene names	PPARGC1B, PERC, PGC1, PGC1B, PPARGC1
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPAR gamma coactivator-1beta) (PGC-1-related estrogen receptor alpha coactivator) (PPARGC-1-beta) (PGC-1-beta).

PS1C2_HUMAN
θ value	8.99809 (rank : 1735)	NC score	0.029445 (rank : 1455)
Query Neighborhood Hits	1762	Target Neighborhood Hits	66	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UIG4	Gene names	PSORS1C2, C6orf17, SPR1
Domain Architecture	No domain graphic available
Description	Psoriasis susceptibility 1 candidate gene 2 protein precursor (SPR1 protein).

PSG10_HUMAN
θ value	8.99809 (rank : 1736)	NC score	0.154225 (rank : 1046)
Query Neighborhood Hits	1762	Target Neighborhood Hits	227	Shared Neighborhood Hits	182
SwissProt Accessions	Q15235, O75244, Q15224	Gene names	PSG10, PSG12
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 10 precursor (PSBG-10) (PSBG- 12).

PYR1_HUMAN
θ value	8.99809 (rank : 1737)	NC score	0.000742 (rank : 1837)
Query Neighborhood Hits	1762	Target Neighborhood Hits	119	Shared Neighborhood Hits	27
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].

RGL2_MOUSE
θ value	8.99809 (rank : 1738)	NC score	0.000935 (rank : 1835)
Query Neighborhood Hits	1762	Target Neighborhood Hits	51	Shared Neighborhood Hits	13
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RM46_MOUSE
θ value	8.99809 (rank : 1739)	NC score	0.004040 (rank : 1784)
Query Neighborhood Hits	1762	Target Neighborhood Hits	22	Shared Neighborhood Hits	6
SwissProt Accessions	Q9EQI8	Gene names	Mrpl46
Domain Architecture	No domain graphic available
Description	39S ribosomal protein L46, mitochondrial precursor (L46mt) (MRP-L46).

RTN2_MOUSE
θ value	8.99809 (rank : 1740)	NC score	0.004049 (rank : 1783)
Query Neighborhood Hits	1762	Target Neighborhood Hits	48	Shared Neighborhood Hits	16
SwissProt Accessions	O70622, O70620	Gene names	Rtn2, Nspl1
Domain Architecture
Description	Reticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like protein 1) (NSPLI).

S12A5_HUMAN
θ value	8.99809 (rank : 1741)	NC score	-0.001255 (rank : 1859)
Query Neighborhood Hits	1762	Target Neighborhood Hits	68	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H2X9, Q5VZ41, Q9H4Z0, Q9ULP4	Gene names	SLC12A5, KCC2, KIAA1176
Domain Architecture
Description	Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (Erythroid K-Cl cotransporter 2) (Neuronal K-Cl cotransporter) (hKCC2).

SETX_HUMAN
θ value	8.99809 (rank : 1742)	NC score	0.010395 (rank : 1682)
Query Neighborhood Hits	1762	Target Neighborhood Hits	368	Shared Neighborhood Hits	84
SwissProt Accessions	Q7Z333, O75120, Q3KQX4, Q68DW5, Q6AZD7, Q7Z3J6, Q8WX33, Q9H9D1, Q9NVP9	Gene names	SETX, ALS4, KIAA0625, SCAR1
Domain Architecture
Description	Probable helicase senataxin (EC 3.6.1.-) (SEN1 homolog).

SFR15_HUMAN
θ value	8.99809 (rank : 1743)	NC score	0.042031 (rank : 1362)
Query Neighborhood Hits	1762	Target Neighborhood Hits	368	Shared Neighborhood Hits	134
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

SHC2_HUMAN
θ value	8.99809 (rank : 1744)	NC score	0.037642 (rank : 1395)
Query Neighborhood Hits	1762	Target Neighborhood Hits	170	Shared Neighborhood Hits	61
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SOS1_MOUSE
θ value	8.99809 (rank : 1745)	NC score	0.008229 (rank : 1710)
Query Neighborhood Hits	1762	Target Neighborhood Hits	281	Shared Neighborhood Hits	84
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SRBS1_HUMAN
θ value	8.99809 (rank : 1746)	NC score	0.026694 (rank : 1483)
Query Neighborhood Hits	1762	Target Neighborhood Hits	396	Shared Neighborhood Hits	104
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SSFA2_HUMAN
θ value	8.99809 (rank : 1747)	NC score	0.002794 (rank : 1803)
Query Neighborhood Hits	1762	Target Neighborhood Hits	40	Shared Neighborhood Hits	11
SwissProt Accessions	P28290, Q96E36	Gene names	SSFA2, CS1
Domain Architecture	No domain graphic available
Description	Sperm-specific antigen 2 (Cleavage signal-1 protein) (CS-1).

SSH2_MOUSE
θ value	8.99809 (rank : 1748)	NC score	-0.003754 (rank : 1883)
Query Neighborhood Hits	1762	Target Neighborhood Hits	119	Shared Neighborhood Hits	19
SwissProt Accessions	Q5SW75, Q3TDK8, Q3TYP8, Q3U2K3, Q5F268, Q5SW74, Q69ZC3, Q76I78	Gene names	Ssh2, Kiaa1725, Ssh2l
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-2L) (mSSH-2L).

SSPO_MOUSE
θ value	8.99809 (rank : 1749)	NC score	0.009056 (rank : 1697)
Query Neighborhood Hits	1762	Target Neighborhood Hits	800	Shared Neighborhood Hits	116
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

SUHW1_HUMAN
θ value	8.99809 (rank : 1750)	NC score	-0.023592 (rank : 1923)
Query Neighborhood Hits	1762	Target Neighborhood Hits	648	Shared Neighborhood Hits	32
SwissProt Accessions	P59817	Gene names	SUHW1
Domain Architecture	No domain graphic available
Description	Suppressor of hairy wing homolog 1 (3'OY11.1).

SYN1_MOUSE
θ value	8.99809 (rank : 1751)	NC score	0.047259 (rank : 1338)
Query Neighborhood Hits	1762	Target Neighborhood Hits	363	Shared Neighborhood Hits	193
SwissProt Accessions	O88935, Q62279, Q8QZT8	Gene names	Syn1, Syn-1
Domain Architecture
Description	Synapsin-1 (Synapsin I).

TCOF_MOUSE
θ value	8.99809 (rank : 1752)	NC score	0.053282 (rank : 1296)
Query Neighborhood Hits	1762	Target Neighborhood Hits	471	Shared Neighborhood Hits	152
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

TDRD7_MOUSE
θ value	8.99809 (rank : 1753)	NC score	0.000063 (rank : 1843)
Query Neighborhood Hits	1762	Target Neighborhood Hits	39	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K1H1, Q8R181	Gene names	Tdrd7, Pctaire2bp
Domain Architecture
Description	Tudor domain-containing protein 7 (Tudor repeat associator with PCTAIRE 2) (Trap).

TIEG3_MOUSE
θ value	8.99809 (rank : 1754)	NC score	-0.025794 (rank : 1933)
Query Neighborhood Hits	1762	Target Neighborhood Hits	774	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K1S5, Q8BI37	Gene names	Tieg3, Tieg2b
Domain Architecture
Description	Transforming growth factor-beta-inducible early growth response protein 3 (TGFB-inducible early growth response protein 3) (TIEG-3) (TGFB-inducible early growth response protein 2b).

TIF1G_MOUSE
θ value	8.99809 (rank : 1755)	NC score	0.003846 (rank : 1788)
Query Neighborhood Hits	1762	Target Neighborhood Hits	498	Shared Neighborhood Hits	106
SwissProt Accessions	Q99PP7, Q6SI71, Q6ZPX5	Gene names	Trim33, Kiaa1113
Domain Architecture	No domain graphic available
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33).

TXLNB_MOUSE
θ value	8.99809 (rank : 1756)	NC score	0.019247 (rank : 1557)
Query Neighborhood Hits	1762	Target Neighborhood Hits	640	Shared Neighborhood Hits	95
SwissProt Accessions	Q8VBT1, Q3UVB8, Q8BUK2	Gene names	Txlnb, Mdp77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77).

VRK3_HUMAN
θ value	8.99809 (rank : 1757)	NC score	0.277559 (rank : 969)
Query Neighborhood Hits	1762	Target Neighborhood Hits	349	Shared Neighborhood Hits	324
SwissProt Accessions	Q8IV63, Q9P2V8	Gene names	VRK3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

WFS1_MOUSE
θ value	8.99809 (rank : 1758)	NC score	0.005768 (rank : 1751)
Query Neighborhood Hits	1762	Target Neighborhood Hits	49	Shared Neighborhood Hits	21
SwissProt Accessions	P56695, Q9Z276	Gene names	Wfs1
Domain Architecture	No domain graphic available
Description	Wolframin.

XRCC1_MOUSE
θ value	8.99809 (rank : 1759)	NC score	0.021151 (rank : 1531)
Query Neighborhood Hits	1762	Target Neighborhood Hits	242	Shared Neighborhood Hits	73
SwissProt Accessions	Q60596, Q3THC5, Q5U435, Q7TNQ5	Gene names	Xrcc1, Xrcc-1
Domain Architecture
Description	DNA-repair protein XRCC1 (X-ray repair cross-complementing protein 1).

ZEP1_HUMAN
θ value	8.99809 (rank : 1760)	NC score	-0.019752 (rank : 1916)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1036	Shared Neighborhood Hits	117
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

ZEP1_MOUSE
θ value	8.99809 (rank : 1761)	NC score	-0.013892 (rank : 1910)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1063	Shared Neighborhood Hits	161
SwissProt Accessions	Q03172	Gene names	Hivep1, Cryabp1, Znf40
Domain Architecture
Description	Zinc finger protein 40 (Transcription factor alphaA-CRYBP1) (Alpha A- crystallin-binding protein I) (Alpha A-CRYBP1).

ZNF19_HUMAN
θ value	8.99809 (rank : 1762)	NC score	-0.026744 (rank : 1937)
Query Neighborhood Hits	1762	Target Neighborhood Hits	751	Shared Neighborhood Hits	40
SwissProt Accessions	P17023, Q86Y66	Gene names	ZNF19, KOX12
Domain Architecture
Description	Zinc finger protein 19 (Zinc finger protein KOX12).

ACVL1_HUMAN
θ value	θ > 10 (rank : 1763)	NC score	0.560430 (rank : 802)
Query Neighborhood Hits	1762	Target Neighborhood Hits	716	Shared Neighborhood Hits	698
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVL1_MOUSE
θ value	θ > 10 (rank : 1764)	NC score	0.580454 (rank : 799)
Query Neighborhood Hits	1762	Target Neighborhood Hits	739	Shared Neighborhood Hits	723
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ANKF1_HUMAN
θ value	θ > 10 (rank : 1765)	NC score	0.062608 (rank : 1241)
Query Neighborhood Hits	1762	Target Neighborhood Hits	126	Shared Neighborhood Hits	52
SwissProt Accessions	Q8N957	Gene names	ANKFN1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and fibronectin type-III domain-containing protein 1.

ANPRA_HUMAN
θ value	θ > 10 (rank : 1766)	NC score	0.413776 (rank : 833)
Query Neighborhood Hits	1762	Target Neighborhood Hits	612	Shared Neighborhood Hits	534
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
θ value	θ > 10 (rank : 1767)	NC score	0.413290 (rank : 834)
Query Neighborhood Hits	1762	Target Neighborhood Hits	600	Shared Neighborhood Hits	526
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_HUMAN
θ value	θ > 10 (rank : 1768)	NC score	0.443502 (rank : 829)
Query Neighborhood Hits	1762	Target Neighborhood Hits	646	Shared Neighborhood Hits	572
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRB_MOUSE
θ value	θ > 10 (rank : 1769)	NC score	0.416795 (rank : 832)
Query Neighborhood Hits	1762	Target Neighborhood Hits	607	Shared Neighborhood Hits	546
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ATN1_HUMAN
θ value	θ > 10 (rank : 1770)	NC score	0.054328 (rank : 1293)
Query Neighborhood Hits	1762	Target Neighborhood Hits	676	Shared Neighborhood Hits	237
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

BMR1B_HUMAN
θ value	θ > 10 (rank : 1771)	NC score	0.598954 (rank : 788)
Query Neighborhood Hits	1762	Target Neighborhood Hits	760	Shared Neighborhood Hits	735
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

BMR1B_MOUSE
θ value	θ > 10 (rank : 1772)	NC score	0.600308 (rank : 785)
Query Neighborhood Hits	1762	Target Neighborhood Hits	758	Shared Neighborhood Hits	736
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

BTNL2_HUMAN
θ value	θ > 10 (rank : 1773)	NC score	0.055056 (rank : 1286)
Query Neighborhood Hits	1762	Target Neighborhood Hits	164	Shared Neighborhood Hits	92
SwissProt Accessions	Q9UIR0, O98261, Q5JYF9, Q5RIF8, Q5SP08, Q5SP09, Q5SRW3, Q5SRW4, Q5SU36, Q95HK0	Gene names	BTNL2
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 2 precursor (BTL-II).

BUB1B_HUMAN
θ value	θ > 10 (rank : 1774)	NC score	0.102169 (rank : 1118)
Query Neighborhood Hits	1762	Target Neighborhood Hits	208	Shared Neighborhood Hits	113
SwissProt Accessions	O60566, O60501, O60627, O60758, O75389, Q96KM4	Gene names	BUB1B, BUBR1, MAD3L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (hBUBR1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L) (SSK1).

BUB1B_MOUSE
θ value	θ > 10 (rank : 1775)	NC score	0.083125 (rank : 1150)
Query Neighborhood Hits	1762	Target Neighborhood Hits	202	Shared Neighborhood Hits	129
SwissProt Accessions	Q9Z1S0	Gene names	Bub1b, Mad3l
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L).

CD276_HUMAN
θ value	θ > 10 (rank : 1776)	NC score	0.147146 (rank : 1058)
Query Neighborhood Hits	1762	Target Neighborhood Hits	261	Shared Neighborhood Hits	146
SwissProt Accessions	Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1	Gene names	CD276, B7H3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3) (4Ig-B7-H3).

CD276_MOUSE
θ value	θ > 10 (rank : 1777)	NC score	0.115428 (rank : 1097)
Query Neighborhood Hits	1762	Target Neighborhood Hits	243	Shared Neighborhood Hits	150
SwissProt Accessions	Q8VE98	Gene names	Cd276, B7h3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3).

CD4_HUMAN
θ value	θ > 10 (rank : 1778)	NC score	0.060411 (rank : 1248)
Query Neighborhood Hits	1762	Target Neighborhood Hits	122	Shared Neighborhood Hits	55
SwissProt Accessions	P01730, Q4ZGK2, Q5U066	Gene names	CD4
Domain Architecture
Description	T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3).

CD79A_HUMAN
θ value	θ > 10 (rank : 1779)	NC score	0.081337 (rank : 1154)
Query Neighborhood Hits	1762	Target Neighborhood Hits	102	Shared Neighborhood Hits	61
SwissProt Accessions	P11912	Gene names	CD79A, IGA, MB1
Domain Architecture
Description	B-cell antigen receptor complex-associated protein alpha-chain precursor (Ig-alpha) (MB-1 membrane glycoprotein) (Surface IgM- associated protein) (Membrane-bound immunoglobulin-associated protein) (CD79a antigen).

CD80_HUMAN
θ value	θ > 10 (rank : 1780)	NC score	0.078346 (rank : 1163)
Query Neighborhood Hits	1762	Target Neighborhood Hits	129	Shared Neighborhood Hits	87
SwissProt Accessions	P33681	Gene names	CD80, CD28LG, CD28LG1, LAB7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (CTLA-4 counter-receptor B7.1) (B7) (BB1).

CD80_MOUSE
θ value	θ > 10 (rank : 1781)	NC score	0.075101 (rank : 1178)
Query Neighborhood Hits	1762	Target Neighborhood Hits	136	Shared Neighborhood Hits	92
SwissProt Accessions	Q00609, Q61332	Gene names	Cd80, B7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (B7).

CEAM1_MOUSE
θ value	θ > 10 (rank : 1782)	NC score	0.255592 (rank : 990)
Query Neighborhood Hits	1762	Target Neighborhood Hits	326	Shared Neighborhood Hits	241
SwissProt Accessions	P31809	Gene names	Ceacam1, Bgp, Bgp1, Bgpd
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (Murine hepatitis virus receptor) (MHV-R) (Biliary glycoprotein D).

CEAM7_HUMAN
θ value	θ > 10 (rank : 1783)	NC score	0.102531 (rank : 1117)
Query Neighborhood Hits	1762	Target Neighborhood Hits	170	Shared Neighborhood Hits	129
SwissProt Accessions	Q14002, O15148, O15149, Q13983, Q9UPJ2	Gene names	CEACAM7, CGM2
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 7 precursor (Carcinoembryonic antigen CGM2).

CHIN_HUMAN
θ value	θ > 10 (rank : 1784)	NC score	0.066645 (rank : 1223)
Query Neighborhood Hits	1762	Target Neighborhood Hits	227	Shared Neighborhood Hits	66
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 1785)	NC score	0.067251 (rank : 1219)
Query Neighborhood Hits	1762	Target Neighborhood Hits	229	Shared Neighborhood Hits	67
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 1786)	NC score	0.067876 (rank : 1214)
Query Neighborhood Hits	1762	Target Neighborhood Hits	220	Shared Neighborhood Hits	66
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_MOUSE
θ value	θ > 10 (rank : 1787)	NC score	0.061201 (rank : 1244)
Query Neighborhood Hits	1762	Target Neighborhood Hits	130	Shared Neighborhood Hits	38
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CN155_HUMAN
θ value	θ > 10 (rank : 1788)	NC score	0.066089 (rank : 1228)
Query Neighborhood Hits	1762	Target Neighborhood Hits	385	Shared Neighborhood Hits	167
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

CO7A1_HUMAN
θ value	θ > 10 (rank : 1789)	NC score	0.081935 (rank : 1153)
Query Neighborhood Hits	1762	Target Neighborhood Hits	807	Shared Neighborhood Hits	285
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

COCA1_HUMAN
θ value	θ > 10 (rank : 1790)	NC score	0.106233 (rank : 1108)
Query Neighborhood Hits	1762	Target Neighborhood Hits	458	Shared Neighborhood Hits	199
SwissProt Accessions	Q99715, Q99716	Gene names	COL12A1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

COCA1_MOUSE
θ value	θ > 10 (rank : 1791)	NC score	0.113485 (rank : 1101)
Query Neighborhood Hits	1762	Target Neighborhood Hits	467	Shared Neighborhood Hits	213
SwissProt Accessions	Q60847, P70322	Gene names	Col12a1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

COEA1_HUMAN
θ value	θ > 10 (rank : 1792)	NC score	0.073176 (rank : 1189)
Query Neighborhood Hits	1762	Target Neighborhood Hits	427	Shared Neighborhood Hits	169
SwissProt Accessions	Q05707, O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67	Gene names	COL14A1, UND
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor (Undulin).

COEA1_MOUSE
θ value	θ > 10 (rank : 1793)	NC score	0.089208 (rank : 1139)
Query Neighborhood Hits	1762	Target Neighborhood Hits	402	Shared Neighborhood Hits	162
SwissProt Accessions	Q80X19, Q8C6X3, Q9WV05	Gene names	Col14a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor.

COKA1_HUMAN
θ value	θ > 10 (rank : 1794)	NC score	0.064338 (rank : 1233)
Query Neighborhood Hits	1762	Target Neighborhood Hits	403	Shared Neighborhood Hits	150
SwissProt Accessions	Q9P218, Q4VXQ4, Q8WUT2, Q96CY9, Q9BQU6, Q9BQU7	Gene names	COL20A1, KIAA1510
Domain Architecture
Description	Collagen alpha-1(XX) chain precursor.

CSF3R_HUMAN
θ value	θ > 10 (rank : 1795)	NC score	0.080209 (rank : 1156)
Query Neighborhood Hits	1762	Target Neighborhood Hits	140	Shared Neighborhood Hits	81
SwissProt Accessions	Q99062	Gene names	CSF3R, GCSFR
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

CSF3R_MOUSE
θ value	θ > 10 (rank : 1796)	NC score	0.061460 (rank : 1243)
Query Neighborhood Hits	1762	Target Neighborhood Hits	104	Shared Neighborhood Hits	57
SwissProt Accessions	P40223	Gene names	Csf3r, Csfgr
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

CT075_HUMAN
θ value	θ > 10 (rank : 1797)	NC score	0.064331 (rank : 1234)
Query Neighborhood Hits	1762	Target Neighborhood Hits	387	Shared Neighborhood Hits	118
SwissProt Accessions	Q8WUT4, Q5JWV6, Q9H419	Gene names	C20orf75
Domain Architecture
Description	Uncharacterized protein C20orf75 precursor.

CXAR_HUMAN
θ value	θ > 10 (rank : 1798)	NC score	0.162346 (rank : 1037)
Query Neighborhood Hits	1762	Target Neighborhood Hits	245	Shared Neighborhood Hits	154
SwissProt Accessions	P78310, O00694, Q8WWT6, Q8WWT7, Q8WWT8, Q9UKV4	Gene names	CXADR, CAR
Domain Architecture
Description	Coxsackievirus and adenovirus receptor precursor (Coxsackievirus B- adenovirus receptor) (hCAR) (CVB3-binding protein) (HCVADR).

CXAR_MOUSE
θ value	θ > 10 (rank : 1799)	NC score	0.152913 (rank : 1049)
Query Neighborhood Hits	1762	Target Neighborhood Hits	250	Shared Neighborhood Hits	153
SwissProt Accessions	P97792, O09052, Q3ULD0, Q91W66, Q99KG0, Q9DBJ8	Gene names	Cxadr, Car
Domain Architecture
Description	Coxsackievirus and adenovirus receptor homolog precursor (CAR) (mCAR).

DAPP1_HUMAN
θ value	θ > 10 (rank : 1800)	NC score	0.050565 (rank : 1315)
Query Neighborhood Hits	1762	Target Neighborhood Hits	227	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DCX_HUMAN
θ value	θ > 10 (rank : 1801)	NC score	0.070757 (rank : 1199)
Query Neighborhood Hits	1762	Target Neighborhood Hits	141	Shared Neighborhood Hits	66
SwissProt Accessions	O43602, O43911	Gene names	DCX, DBCN, LISX
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

DCX_MOUSE
θ value	θ > 10 (rank : 1802)	NC score	0.066555 (rank : 1224)
Query Neighborhood Hits	1762	Target Neighborhood Hits	124	Shared Neighborhood Hits	47
SwissProt Accessions	O88809	Gene names	Dcx, Dcn
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

DGKB_HUMAN
θ value	θ > 10 (rank : 1803)	NC score	0.050301 (rank : 1318)
Query Neighborhood Hits	1762	Target Neighborhood Hits	238	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y6T7, O75241, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29	Gene names	DGKB, DAGK2, KIAA0718
Domain Architecture
Description	Diacylglycerol kinase beta (EC 2.7.1.107) (Diglyceride kinase beta) (DGK-beta) (DAG kinase beta) (90 kDa diacylglycerol kinase).

DGKD_HUMAN
θ value	θ > 10 (rank : 1804)	NC score	0.067671 (rank : 1217)
Query Neighborhood Hits	1762	Target Neighborhood Hits	231	Shared Neighborhood Hits	78
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

DGKH_HUMAN
θ value	θ > 10 (rank : 1805)	NC score	0.063254 (rank : 1238)
Query Neighborhood Hits	1762	Target Neighborhood Hits	255	Shared Neighborhood Hits	74
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

DGKK_HUMAN
θ value	θ > 10 (rank : 1806)	NC score	0.057243 (rank : 1273)
Query Neighborhood Hits	1762	Target Neighborhood Hits	378	Shared Neighborhood Hits	182
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

DGKQ_HUMAN
θ value	θ > 10 (rank : 1807)	NC score	0.062923 (rank : 1239)
Query Neighborhood Hits	1762	Target Neighborhood Hits	131	Shared Neighborhood Hits	39
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

EMB_HUMAN
θ value	θ > 10 (rank : 1808)	NC score	0.067160 (rank : 1220)
Query Neighborhood Hits	1762	Target Neighborhood Hits	54	Shared Neighborhood Hits	42
SwissProt Accessions	Q6PCB8	Gene names	EMB
Domain Architecture	No domain graphic available
Description	Embigin precursor.

EMB_MOUSE
θ value	θ > 10 (rank : 1809)	NC score	0.123757 (rank : 1081)
Query Neighborhood Hits	1762	Target Neighborhood Hits	83	Shared Neighborhood Hits	73
SwissProt Accessions	P21995, Q3UFF1, Q8C2J8, Q8C543, Q96C38	Gene names	Emb, Gp70
Domain Architecture
Description	Embigin precursor (Teratocarcinoma glycoprotein Gp-70).

FCERA_HUMAN
θ value	θ > 10 (rank : 1810)	NC score	0.090767 (rank : 1137)
Query Neighborhood Hits	1762	Target Neighborhood Hits	150	Shared Neighborhood Hits	107
SwissProt Accessions	P12319	Gene names	FCER1A, FCE1A
Domain Architecture
Description	High affinity immunoglobulin epsilon receptor alpha-subunit precursor (FcERI) (IgE Fc receptor, alpha-subunit) (Fc-epsilon RI-alpha).

FCG2B_HUMAN
θ value	θ > 10 (rank : 1811)	NC score	0.052983 (rank : 1301)
Query Neighborhood Hits	1762	Target Neighborhood Hits	116	Shared Neighborhood Hits	73
SwissProt Accessions	P31994, O95649, Q53X85, Q5VXA9, Q8NIA1	Gene names	FCGR2B, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-b precursor (Fc-gamma RII-b) (FcRII-b) (IgG Fc receptor II-b) (Fc-gamma-RIIb) (CD32 antigen) (CDw32).

FCG2C_HUMAN
θ value	θ > 10 (rank : 1812)	NC score	0.052646 (rank : 1303)
Query Neighborhood Hits	1762	Target Neighborhood Hits	118	Shared Neighborhood Hits	75
SwissProt Accessions	P31995, O00523, O00524, O00525	Gene names	FCGR2C, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-c precursor (Fc-gamma RII-c) (FcRII-c) (IgG Fc receptor II-c) (Fc-gamma-RIIc) (CD32 antigen) (CDw32).

FCGR1_HUMAN
θ value	θ > 10 (rank : 1813)	NC score	0.085223 (rank : 1145)
Query Neighborhood Hits	1762	Target Neighborhood Hits	145	Shared Neighborhood Hits	98
SwissProt Accessions	P12314, P12315, Q92495, Q92663	Gene names	FCGR1A, FCG1, FCGR1, IGFR1
Domain Architecture
Description	High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma RI) (FcRI) (IgG Fc receptor I) (CD64 antigen).

FCGR1_MOUSE
θ value	θ > 10 (rank : 1814)	NC score	0.065269 (rank : 1231)
Query Neighborhood Hits	1762	Target Neighborhood Hits	123	Shared Neighborhood Hits	86
SwissProt Accessions	P26151	Gene names	Fcgr1, Fcg1
Domain Architecture
Description	High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma RI) (FcRI) (IgG Fc receptor I).

FCRL2_HUMAN
θ value	θ > 10 (rank : 1815)	NC score	0.231280 (rank : 999)
Query Neighborhood Hits	1762	Target Neighborhood Hits	251	Shared Neighborhood Hits	191
SwissProt Accessions	Q96LA5, Q6NTA1, Q9BZI4, Q9BZI5, Q9BZI6	Gene names	FCRL2, FCRH2, IFGP4, IRTA4, SPAP1
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 2 precursor (SH2 domain-containing phosphatase anchor protein 1) (Fc receptor homolog 2) (FcRH2) (Immunoglobulin receptor translocation-associated 4 protein).

FCRL5_HUMAN
θ value	θ > 10 (rank : 1816)	NC score	0.240696 (rank : 995)
Query Neighborhood Hits	1762	Target Neighborhood Hits	267	Shared Neighborhood Hits	211
SwissProt Accessions	Q96RD9, Q495Q2, Q495Q4, Q5VYK9, Q6UY46	Gene names	FCRL5, FCRH5, IRTA2
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 5 precursor (Immunoglobulin receptor translocation-associated gene 2 protein) (BXMAS1) (CD307 antigen).

FPRP_HUMAN
θ value	θ > 10 (rank : 1817)	NC score	0.063949 (rank : 1236)
Query Neighborhood Hits	1762	Target Neighborhood Hits	130	Shared Neighborhood Hits	84
SwissProt Accessions	Q9P2B2, Q8N2K6	Gene names	PTGFRN, CD9P1, FPRP, KIAA1436
Domain Architecture
Description	Prostaglandin F2 receptor negative regulator precursor (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD9 partner 1) (CD9P-1) (CD315 antigen).

FPRP_MOUSE
θ value	θ > 10 (rank : 1818)	NC score	0.059551 (rank : 1255)
Query Neighborhood Hits	1762	Target Neighborhood Hits	116	Shared Neighborhood Hits	66
SwissProt Accessions	Q9WV91	Gene names	Ptgfrn, Fprp
Domain Architecture
Description	Prostaglandin F2 receptor negative regulator precursor (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD315 antigen).

GGN_HUMAN
θ value	θ > 10 (rank : 1819)	NC score	0.050925 (rank : 1308)
Query Neighborhood Hits	1762	Target Neighborhood Hits	269	Shared Neighborhood Hits	146
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

GRAP2_HUMAN
θ value	θ > 10 (rank : 1820)	NC score	0.071860 (rank : 1194)
Query Neighborhood Hits	1762	Target Neighborhood Hits	304	Shared Neighborhood Hits	76
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 1821)	NC score	0.070355 (rank : 1203)
Query Neighborhood Hits	1762	Target Neighborhood Hits	297	Shared Neighborhood Hits	74
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 1822)	NC score	0.075056 (rank : 1179)
Query Neighborhood Hits	1762	Target Neighborhood Hits	307	Shared Neighborhood Hits	81
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 1823)	NC score	0.074032 (rank : 1182)
Query Neighborhood Hits	1762	Target Neighborhood Hits	309	Shared Neighborhood Hits	79
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 1824)	NC score	0.071842 (rank : 1195)
Query Neighborhood Hits	1762	Target Neighborhood Hits	310	Shared Neighborhood Hits	76
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 1825)	NC score	0.071786 (rank : 1196)
Query Neighborhood Hits	1762	Target Neighborhood Hits	312	Shared Neighborhood Hits	76
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRP3_HUMAN
θ value	θ > 10 (rank : 1826)	NC score	0.092741 (rank : 1133)
Query Neighborhood Hits	1762	Target Neighborhood Hits	131	Shared Neighborhood Hits	43
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

GSCR1_HUMAN
θ value	θ > 10 (rank : 1827)	NC score	0.070622 (rank : 1200)
Query Neighborhood Hits	1762	Target Neighborhood Hits	674	Shared Neighborhood Hits	275
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

I12R1_HUMAN
θ value	θ > 10 (rank : 1828)	NC score	0.059385 (rank : 1258)
Query Neighborhood Hits	1762	Target Neighborhood Hits	78	Shared Neighborhood Hits	51
SwissProt Accessions	P42701	Gene names	IL12RB1, IL12R, IL12RB
Domain Architecture
Description	Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component) (IL- 12RB1) (CD212 antigen).

I12R2_HUMAN
θ value	θ > 10 (rank : 1829)	NC score	0.100924 (rank : 1122)
Query Neighborhood Hits	1762	Target Neighborhood Hits	163	Shared Neighborhood Hits	93
SwissProt Accessions	Q99665	Gene names	IL12RB2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

I12R2_MOUSE
θ value	θ > 10 (rank : 1830)	NC score	0.101683 (rank : 1120)
Query Neighborhood Hits	1762	Target Neighborhood Hits	143	Shared Neighborhood Hits	88
SwissProt Accessions	P97378	Gene names	Il12rb2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

ICAM1_HUMAN
θ value	θ > 10 (rank : 1831)	NC score	0.071958 (rank : 1193)
Query Neighborhood Hits	1762	Target Neighborhood Hits	80	Shared Neighborhood Hits	67
SwissProt Accessions	P05362, Q96B50	Gene names	ICAM1
Domain Architecture
Description	Intercellular adhesion molecule 1 precursor (ICAM-1) (Major group rhinovirus receptor) (CD54 antigen).

ICAM1_MOUSE
θ value	θ > 10 (rank : 1832)	NC score	0.076482 (rank : 1174)
Query Neighborhood Hits	1762	Target Neighborhood Hits	99	Shared Neighborhood Hits	83
SwissProt Accessions	P13597, Q61828	Gene names	Icam1, Icam-1
Domain Architecture
Description	Intercellular adhesion molecule 1 precursor (ICAM-1) (MALA-2).

IGS21_HUMAN
θ value	θ > 10 (rank : 1833)	NC score	0.105710 (rank : 1110)
Query Neighborhood Hits	1762	Target Neighborhood Hits	123	Shared Neighborhood Hits	98
SwissProt Accessions	Q96ID5, Q8NBR8	Gene names	IGSF21
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 21 precursor.

IGS21_MOUSE
θ value	θ > 10 (rank : 1834)	NC score	0.104690 (rank : 1113)
Query Neighborhood Hits	1762	Target Neighborhood Hits	118	Shared Neighborhood Hits	95
SwissProt Accessions	Q7TNR6	Gene names	Igsf21
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 21 precursor.

IGSF2_HUMAN
θ value	θ > 10 (rank : 1835)	NC score	0.066181 (rank : 1227)
Query Neighborhood Hits	1762	Target Neighborhood Hits	208	Shared Neighborhood Hits	92
SwissProt Accessions	Q93033, Q15856	Gene names	IGSF2, CD101, EWI101, V7
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 2 precursor (Glu-Trp-Ile EWI motif- containing protein 101) (EWI-101) (Cell surface glycoprotein V7) (CD101 antigen).

IL1R1_MOUSE
θ value	θ > 10 (rank : 1836)	NC score	0.119958 (rank : 1088)
Query Neighborhood Hits	1762	Target Neighborhood Hits	142	Shared Neighborhood Hits	120
SwissProt Accessions	P13504	Gene names	Il1r1, Il-1r1, Il1ra
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (p80) (CD121a antigen).

IL6RB_HUMAN
θ value	θ > 10 (rank : 1837)	NC score	0.135838 (rank : 1069)
Query Neighborhood Hits	1762	Target Neighborhood Hits	181	Shared Neighborhood Hits	103
SwissProt Accessions	P40189, Q9UQ41	Gene names	IL6ST
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin M receptor) (CD130 antigen) (CDw130).

IL6RB_MOUSE
θ value	θ > 10 (rank : 1838)	NC score	0.115254 (rank : 1098)
Query Neighborhood Hits	1762	Target Neighborhood Hits	168	Shared Neighborhood Hits	103
SwissProt Accessions	Q00560	Gene names	Il6st
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (CD130 antigen).

ILK1_HUMAN
θ value	θ > 10 (rank : 1839)	NC score	0.410724 (rank : 835)
Query Neighborhood Hits	1762	Target Neighborhood Hits	857	Shared Neighborhood Hits	585
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 1840)	NC score	0.398366 (rank : 848)
Query Neighborhood Hits	1762	Target Neighborhood Hits	848	Shared Neighborhood Hits	579
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 1841)	NC score	0.408587 (rank : 836)
Query Neighborhood Hits	1762	Target Neighborhood Hits	858	Shared Neighborhood Hits	586
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ILRL1_MOUSE
θ value	θ > 10 (rank : 1842)	NC score	0.086157 (rank : 1141)
Query Neighborhood Hits	1762	Target Neighborhood Hits	172	Shared Neighborhood Hits	124
SwissProt Accessions	P14719, Q05208	Gene names	Il1rl1, Ly84, St2, Ste2
Domain Architecture
Description	Interleukin-1 receptor-like 1 precursor (ST2 protein) (T1 protein) (Lymphocyte antigen 84).

ILRL2_HUMAN
θ value	θ > 10 (rank : 1843)	NC score	0.077041 (rank : 1168)
Query Neighborhood Hits	1762	Target Neighborhood Hits	112	Shared Neighborhood Hits	94
SwissProt Accessions	Q9HB29, Q13525, Q45H74	Gene names	IL1RL2, IL1RRP2
Domain Architecture
Description	Interleukin-1 receptor-like 2 precursor (IL-1Rrp2) (Interleukin-1 receptor-related protein 2) (IL1R-rp2).

IRAK3_MOUSE
θ value	θ > 10 (rank : 1844)	NC score	0.589214 (rank : 794)
Query Neighborhood Hits	1762	Target Neighborhood Hits	628	Shared Neighborhood Hits	596
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

ITB4_HUMAN
θ value	θ > 10 (rank : 1845)	NC score	0.122043 (rank : 1083)
Query Neighborhood Hits	1762	Target Neighborhood Hits	458	Shared Neighborhood Hits	150
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

JAML1_HUMAN
θ value	θ > 10 (rank : 1846)	NC score	0.050881 (rank : 1310)
Query Neighborhood Hits	1762	Target Neighborhood Hits	108	Shared Neighborhood Hits	53
SwissProt Accessions	Q86YT9, Q5DTC6, Q7Z499, Q8N9I7, Q8NF70	Gene names	AMICA1, JAML
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule-like precursor (Dendritic cell-specific protein CREA7-1) (Adhesion molecule interacting with CXADR antigen 1).

KALM_HUMAN
θ value	θ > 10 (rank : 1847)	NC score	0.109567 (rank : 1103)
Query Neighborhood Hits	1762	Target Neighborhood Hits	114	Shared Neighborhood Hits	70
SwissProt Accessions	P23352	Gene names	KAL1, ADMLX, KAL, KALIG1
Domain Architecture
Description	Anosmin-1 precursor (Kallmann syndrome protein) (Adhesion molecule- like X-linked).

LAG3_HUMAN
θ value	θ > 10 (rank : 1848)	NC score	0.082799 (rank : 1152)
Query Neighborhood Hits	1762	Target Neighborhood Hits	129	Shared Neighborhood Hits	78
SwissProt Accessions	P18627	Gene names	LAG3, FDC
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (FDC protein) (CD223 antigen).

LCP2_HUMAN
θ value	θ > 10 (rank : 1849)	NC score	0.058529 (rank : 1262)
Query Neighborhood Hits	1762	Target Neighborhood Hits	531	Shared Neighborhood Hits	192
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LIFR_HUMAN
θ value	θ > 10 (rank : 1850)	NC score	0.109318 (rank : 1104)
Query Neighborhood Hits	1762	Target Neighborhood Hits	130	Shared Neighborhood Hits	75
SwissProt Accessions	P42702, Q6LCD9	Gene names	LIFR
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (CD118 antigen).

LIFR_MOUSE
θ value	θ > 10 (rank : 1851)	NC score	0.100523 (rank : 1124)
Query Neighborhood Hits	1762	Target Neighborhood Hits	127	Shared Neighborhood Hits	70
SwissProt Accessions	P42703	Gene names	Lifr
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (D-factor/LIF receptor) (CD118 antigen).

MADCA_HUMAN
θ value	θ > 10 (rank : 1852)	NC score	0.058139 (rank : 1267)
Query Neighborhood Hits	1762	Target Neighborhood Hits	221	Shared Neighborhood Hits	121
SwissProt Accessions	Q13477, O60222, O75867	Gene names	MADCAM1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (hMAdCAM-1).

MBD6_HUMAN
θ value	θ > 10 (rank : 1853)	NC score	0.060731 (rank : 1247)
Query Neighborhood Hits	1762	Target Neighborhood Hits	349	Shared Neighborhood Hits	161
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

MFAP3_HUMAN
θ value	θ > 10 (rank : 1854)	NC score	0.072837 (rank : 1191)
Query Neighborhood Hits	1762	Target Neighborhood Hits	91	Shared Neighborhood Hits	80
SwissProt Accessions	P55082, Q9NXA7	Gene names	MFAP3
Domain Architecture
Description	Microfibril-associated glycoprotein 3 precursor.

MFAP3_MOUSE
θ value	θ > 10 (rank : 1855)	NC score	0.067739 (rank : 1216)
Query Neighborhood Hits	1762	Target Neighborhood Hits	97	Shared Neighborhood Hits	85
SwissProt Accessions	Q922T2, Q8BHK5	Gene names	Mfap3
Domain Architecture	No domain graphic available
Description	Microfibril-associated glycoprotein 3 precursor.

MLKL_HUMAN
θ value	θ > 10 (rank : 1856)	NC score	0.531391 (rank : 815)
Query Neighborhood Hits	1762	Target Neighborhood Hits	600	Shared Neighborhood Hits	564
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MOX2R_HUMAN
θ value	θ > 10 (rank : 1857)	NC score	0.055510 (rank : 1282)
Query Neighborhood Hits	1762	Target Neighborhood Hits	51	Shared Neighborhood Hits	39
SwissProt Accessions	Q8TD46, Q8TD44, Q8TD45, Q8TD52	Gene names	CD200R1, CD200R, CRTR2, MOX2R, OX2R
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor).

MOX2R_MOUSE
θ value	θ > 10 (rank : 1858)	NC score	0.119096 (rank : 1090)
Query Neighborhood Hits	1762	Target Neighborhood Hits	110	Shared Neighborhood Hits	88
SwissProt Accessions	Q9ES57	Gene names	Cd200r1, Mox2r, Ox2r
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor).

MUC7_HUMAN
θ value	θ > 10 (rank : 1859)	NC score	0.079312 (rank : 1158)
Query Neighborhood Hits	1762	Target Neighborhood Hits	538	Shared Neighborhood Hits	236
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

NCK1_HUMAN
θ value	θ > 10 (rank : 1860)	NC score	0.068300 (rank : 1211)
Query Neighborhood Hits	1762	Target Neighborhood Hits	312	Shared Neighborhood Hits	76
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 1861)	NC score	0.068167 (rank : 1212)
Query Neighborhood Hits	1762	Target Neighborhood Hits	310	Shared Neighborhood Hits	75
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NCOR2_HUMAN
θ value	θ > 10 (rank : 1862)	NC score	0.050905 (rank : 1309)
Query Neighborhood Hits	1762	Target Neighborhood Hits	870	Shared Neighborhood Hits	263
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

NTKL_HUMAN
θ value	θ > 10 (rank : 1863)	NC score	0.259203 (rank : 987)
Query Neighborhood Hits	1762	Target Neighborhood Hits	266	Shared Neighborhood Hits	228
SwissProt Accessions	Q96KG9, Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53	Gene names	SCYL1, GKLP, NTKL, TAPK, TEIF, TRAP
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (Teratoma- associated tyrosine kinase) (Telomerase transcriptional element- interacting factor) (Telomerase regulation-associated protein).

OX2G_HUMAN
θ value	θ > 10 (rank : 1864)	NC score	0.070467 (rank : 1201)
Query Neighborhood Hits	1762	Target Neighborhood Hits	100	Shared Neighborhood Hits	68
SwissProt Accessions	P41217, Q6J2Q6, Q6PIQ4, Q8TB85, Q9H3J3	Gene names	CD200, MOX2
Domain Architecture
Description	OX-2 membrane glycoprotein precursor (CD200 antigen).

OX2G_MOUSE
θ value	θ > 10 (rank : 1865)	NC score	0.083947 (rank : 1148)
Query Neighborhood Hits	1762	Target Neighborhood Hits	105	Shared Neighborhood Hits	81
SwissProt Accessions	O54901, O54816, Q9JHD5	Gene names	Cd200, Mox2
Domain Architecture
Description	OX-2 membrane glycoprotein precursor (MRC OX-2 antigen) (CD200 antigen).

PACE1_HUMAN
θ value	θ > 10 (rank : 1866)	NC score	0.066265 (rank : 1226)
Query Neighborhood Hits	1762	Target Neighborhood Hits	74	Shared Neighborhood Hits	50
SwissProt Accessions	Q8IZE3, Q5THA6, Q5THA8, Q8IZN9, Q96C56, Q9UBK6	Gene names	SCYL3, PACE1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

PACE1_MOUSE
θ value	θ > 10 (rank : 1867)	NC score	0.070311 (rank : 1204)
Query Neighborhood Hits	1762	Target Neighborhood Hits	92	Shared Neighborhood Hits	64
SwissProt Accessions	Q9DBQ7, Q6NY01, Q8BQC9, Q8BRJ1	Gene names	Scyl3, Pace1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

PCQAP_HUMAN
θ value	θ > 10 (rank : 1868)	NC score	0.053072 (rank : 1299)
Query Neighborhood Hits	1762	Target Neighborhood Hits	549	Shared Neighborhood Hits	175
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

PDL1_HUMAN
θ value	θ > 10 (rank : 1869)	NC score	0.115771 (rank : 1096)
Query Neighborhood Hits	1762	Target Neighborhood Hits	195	Shared Neighborhood Hits	126
SwissProt Accessions	Q9NZQ7, Q66RK1, Q6WEX4, Q9NUZ5	Gene names	CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

PDL1_MOUSE
θ value	θ > 10 (rank : 1870)	NC score	0.091531 (rank : 1135)
Query Neighborhood Hits	1762	Target Neighborhood Hits	168	Shared Neighborhood Hits	112
SwissProt Accessions	Q9EP73	Gene names	Cd274, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

PDL2_HUMAN
θ value	θ > 10 (rank : 1871)	NC score	0.076065 (rank : 1176)
Query Neighborhood Hits	1762	Target Neighborhood Hits	114	Shared Neighborhood Hits	74
SwissProt Accessions	Q9BQ51, Q5T7Z6, Q6JXL8, Q6JXL9	Gene names	PDCD1LG2, B7DC, CD273, PDCD1L2, PDL2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

PDL2_MOUSE
θ value	θ > 10 (rank : 1872)	NC score	0.104739 (rank : 1112)
Query Neighborhood Hits	1762	Target Neighborhood Hits	116	Shared Neighborhood Hits	86
SwissProt Accessions	Q9WUL5	Gene names	Pdcd1lg2, B7dc, Btdc, Cd273, Pdl2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

PDZD8_HUMAN
θ value	θ > 10 (rank : 1873)	NC score	0.076419 (rank : 1175)
Query Neighborhood Hits	1762	Target Neighborhood Hits	185	Shared Neighborhood Hits	65
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PECA1_HUMAN
θ value	θ > 10 (rank : 1874)	NC score	0.144631 (rank : 1062)
Query Neighborhood Hits	1762	Target Neighborhood Hits	178	Shared Neighborhood Hits	139
SwissProt Accessions	P16284, Q6LDA9, Q8TBH1, Q96RF5, Q96RF6, Q9NP65, Q9NPB7, Q9NPG9, Q9NQS9, Q9NQT0, Q9NQT1, Q9NQT2	Gene names	PECAM1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (EndoCAM) (GPIIA') (CD31 antigen).

PIGR_HUMAN
θ value	θ > 10 (rank : 1875)	NC score	0.116932 (rank : 1094)
Query Neighborhood Hits	1762	Target Neighborhood Hits	164	Shared Neighborhood Hits	99
SwissProt Accessions	P01833, Q8IZY7	Gene names	PIGR
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) (Hepatocellular carcinoma-associated protein TB6) [Contains: Secretory component].

PIGR_MOUSE
θ value	θ > 10 (rank : 1876)	NC score	0.124042 (rank : 1080)
Query Neighborhood Hits	1762	Target Neighborhood Hits	214	Shared Neighborhood Hits	122
SwissProt Accessions	O70570	Gene names	Pigr
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) [Contains: Secretory component].

PRB3_HUMAN
θ value	θ > 10 (rank : 1877)	NC score	0.069188 (rank : 1208)
Query Neighborhood Hits	1762	Target Neighborhood Hits	318	Shared Neighborhood Hits	166
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

PRPK_HUMAN
θ value	θ > 10 (rank : 1878)	NC score	0.146203 (rank : 1059)
Query Neighborhood Hits	1762	Target Neighborhood Hits	131	Shared Neighborhood Hits	127
SwissProt Accessions	Q96S44, Q3T977, Q5JZ01, Q96FM7, Q9NQE6	Gene names	TP53RK, C20orf64, PRPK
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PRPK_MOUSE
θ value	θ > 10 (rank : 1879)	NC score	0.145811 (rank : 1060)
Query Neighborhood Hits	1762	Target Neighborhood Hits	139	Shared Neighborhood Hits	130
SwissProt Accessions	Q99PW4, Q91W37, Q9CZ32	Gene names	Tp53rk, Prpk, Trp53rk
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PRR12_HUMAN
θ value	θ > 10 (rank : 1880)	NC score	0.076957 (rank : 1170)
Query Neighborhood Hits	1762	Target Neighborhood Hits	460	Shared Neighborhood Hits	208
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

PTPRK_HUMAN
θ value	θ > 10 (rank : 1881)	NC score	0.077657 (rank : 1164)
Query Neighborhood Hits	1762	Target Neighborhood Hits	228	Shared Neighborhood Hits	122
SwissProt Accessions	Q15262, Q14763	Gene names	PTPRK, PTPK
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRK_MOUSE
θ value	θ > 10 (rank : 1882)	NC score	0.078893 (rank : 1160)
Query Neighborhood Hits	1762	Target Neighborhood Hits	223	Shared Neighborhood Hits	120
SwissProt Accessions	P35822	Gene names	Ptprk, Ptpk
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRT_HUMAN
θ value	θ > 10 (rank : 1883)	NC score	0.085393 (rank : 1144)
Query Neighborhood Hits	1762	Target Neighborhood Hits	217	Shared Neighborhood Hits	114
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

PTPRT_MOUSE
θ value	θ > 10 (rank : 1884)	NC score	0.085948 (rank : 1143)
Query Neighborhood Hits	1762	Target Neighborhood Hits	219	Shared Neighborhood Hits	114
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

PVRL1_HUMAN
θ value	θ > 10 (rank : 1885)	NC score	0.124496 (rank : 1078)
Query Neighborhood Hits	1762	Target Neighborhood Hits	219	Shared Neighborhood Hits	153
SwissProt Accessions	Q15223, O75465, Q9HBE6, Q9HBW2	Gene names	PVRL1, HVEC, PRR1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (Herpesvirus Ig-like receptor) (HIgR) (CD111 antigen).

PVRL1_MOUSE
θ value	θ > 10 (rank : 1886)	NC score	0.114615 (rank : 1099)
Query Neighborhood Hits	1762	Target Neighborhood Hits	201	Shared Neighborhood Hits	141
SwissProt Accessions	Q9JKF6, Q9ERL5, Q9JI17	Gene names	Pvrl1, Hvec, Prr1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (CD111 antigen).

PVRL2_HUMAN
θ value	θ > 10 (rank : 1887)	NC score	0.092652 (rank : 1134)
Query Neighborhood Hits	1762	Target Neighborhood Hits	185	Shared Neighborhood Hits	117
SwissProt Accessions	Q92692, O75455, Q96J29	Gene names	PVRL2, HVEB, PRR2
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Herpes virus entry mediator B) (HveB) (Nectin-2) (CD112 antigen).

PVRL2_MOUSE
θ value	θ > 10 (rank : 1888)	NC score	0.103212 (rank : 1116)
Query Neighborhood Hits	1762	Target Neighborhood Hits	242	Shared Neighborhood Hits	123
SwissProt Accessions	P32507, Q62096	Gene names	Pvrl2, Mph, Pvr, Pvs
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Murine herpesvirus entry protein B) (mHveB) (Nectin-2) (Poliovirus receptor homolog) (CD112 antigen).

PVRL3_HUMAN
θ value	θ > 10 (rank : 1889)	NC score	0.131614 (rank : 1073)
Query Neighborhood Hits	1762	Target Neighborhood Hits	204	Shared Neighborhood Hits	137
SwissProt Accessions	Q9NQS3, Q6NVZ3, Q8WVU4, Q9BVA9, Q9Y412	Gene names	PVRL3, PRR3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Nectin-3) (CDw113 antigen).

PVRL3_MOUSE
θ value	θ > 10 (rank : 1890)	NC score	0.136277 (rank : 1068)
Query Neighborhood Hits	1762	Target Neighborhood Hits	212	Shared Neighborhood Hits	143
SwissProt Accessions	Q9JLB9, Q9D006, Q9JLB7, Q9JLB8	Gene names	Pvrl3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Cell adhesion molecule nectin-3) (Nectin-3) (CDw113 antigen).

PVR_HUMAN
θ value	θ > 10 (rank : 1891)	NC score	0.105758 (rank : 1109)
Query Neighborhood Hits	1762	Target Neighborhood Hits	195	Shared Neighborhood Hits	118
SwissProt Accessions	P15151, P15152, Q15267, Q15268, Q96BJ1	Gene names	PVR, PVS
Domain Architecture
Description	Poliovirus receptor precursor (Nectin-like protein 5) (Necl-5) (CD155 antigen).

PXK_HUMAN
θ value	θ > 10 (rank : 1892)	NC score	0.127507 (rank : 1076)
Query Neighborhood Hits	1762	Target Neighborhood Hits	216	Shared Neighborhood Hits	152
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

PXK_MOUSE
θ value	θ > 10 (rank : 1893)	NC score	0.173075 (rank : 1030)
Query Neighborhood Hits	1762	Target Neighborhood Hits	320	Shared Neighborhood Hits	220
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

RASA1_HUMAN
θ value	θ > 10 (rank : 1894)	NC score	0.059192 (rank : 1259)
Query Neighborhood Hits	1762	Target Neighborhood Hits	258	Shared Neighborhood Hits	69
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RASF1_HUMAN
θ value	θ > 10 (rank : 1895)	NC score	0.060311 (rank : 1250)
Query Neighborhood Hits	1762	Target Neighborhood Hits	62	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NS23, O14571, O60539, O60710, Q9HB04, Q9HB18, Q9NS22, Q9UND4, Q9UND5	Gene names	RASSF1, RDA32
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1.

RASF1_MOUSE
θ value	θ > 10 (rank : 1896)	NC score	0.073508 (rank : 1188)
Query Neighborhood Hits	1762	Target Neighborhood Hits	74	Shared Neighborhood Hits	33
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

RERE_HUMAN
θ value	θ > 10 (rank : 1897)	NC score	0.050220 (rank : 1319)
Query Neighborhood Hits	1762	Target Neighborhood Hits	779	Shared Neighborhood Hits	266
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

RIMB2_HUMAN
θ value	θ > 10 (rank : 1898)	NC score	0.056717 (rank : 1276)
Query Neighborhood Hits	1762	Target Neighborhood Hits	263	Shared Neighborhood Hits	91
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 1899)	NC score	0.052722 (rank : 1302)
Query Neighborhood Hits	1762	Target Neighborhood Hits	246	Shared Neighborhood Hits	76
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RN5A_HUMAN
θ value	θ > 10 (rank : 1900)	NC score	0.140112 (rank : 1065)
Query Neighborhood Hits	1762	Target Neighborhood Hits	608	Shared Neighborhood Hits	335
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

SFPQ_MOUSE
θ value	θ > 10 (rank : 1901)	NC score	0.050200 (rank : 1320)
Query Neighborhood Hits	1762	Target Neighborhood Hits	958	Shared Neighborhood Hits	259
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

SH21A_HUMAN
θ value	θ > 10 (rank : 1902)	NC score	0.053037 (rank : 1300)
Query Neighborhood Hits	1762	Target Neighborhood Hits	89	Shared Neighborhood Hits	38
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 1903)	NC score	0.058449 (rank : 1263)
Query Neighborhood Hits	1762	Target Neighborhood Hits	89	Shared Neighborhood Hits	40
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 1904)	NC score	0.058756 (rank : 1260)
Query Neighborhood Hits	1762	Target Neighborhood Hits	101	Shared Neighborhood Hits	41
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 1905)	NC score	0.064479 (rank : 1232)
Query Neighborhood Hits	1762	Target Neighborhood Hits	101	Shared Neighborhood Hits	40
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SHPS1_HUMAN
θ value	θ > 10 (rank : 1906)	NC score	0.064057 (rank : 1235)
Query Neighborhood Hits	1762	Target Neighborhood Hits	455	Shared Neighborhood Hits	105
SwissProt Accessions	P78324, O00683, O43799, Q8N517, Q8TAL8, Q9H0Z2, Q9UDX2, Q9UIJ6, Q9Y4U9	Gene names	SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (Sirp-alpha-2) (Sirp-alpha- 3) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (Macrophage fusion receptor) (p84) (CD172a antigen).

SIGL9_HUMAN
θ value	θ > 10 (rank : 1907)	NC score	0.066012 (rank : 1229)
Query Neighborhood Hits	1762	Target Neighborhood Hits	76	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y336, Q9BYI9	Gene names	SIGLEC9
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 9 precursor (Siglec-9) (Protein FOAP-9).

SIRB1_HUMAN
θ value	θ > 10 (rank : 1908)	NC score	0.054814 (rank : 1288)
Query Neighborhood Hits	1762	Target Neighborhood Hits	422	Shared Neighborhood Hits	96
SwissProt Accessions	O00241, Q5TFR0, Q8TB12, Q9H1U5, Q9Y4V0	Gene names	SIRPB1
Domain Architecture
Description	Signal-regulatory protein beta-1 precursor (SIRP-beta-1) (CD172b antigen).

SLAP1_HUMAN
θ value	θ > 10 (rank : 1909)	NC score	0.096369 (rank : 1129)
Query Neighborhood Hits	1762	Target Neighborhood Hits	113	Shared Neighborhood Hits	43
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 1910)	NC score	0.094937 (rank : 1131)
Query Neighborhood Hits	1762	Target Neighborhood Hits	117	Shared Neighborhood Hits	42
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 1911)	NC score	0.097713 (rank : 1128)
Query Neighborhood Hits	1762	Target Neighborhood Hits	139	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 1912)	NC score	0.100718 (rank : 1123)
Query Neighborhood Hits	1762	Target Neighborhood Hits	136	Shared Neighborhood Hits	47
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SORL_HUMAN
θ value	θ > 10 (rank : 1913)	NC score	0.073652 (rank : 1186)
Query Neighborhood Hits	1762	Target Neighborhood Hits	440	Shared Neighborhood Hits	121
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

SORL_MOUSE
θ value	θ > 10 (rank : 1914)	NC score	0.072596 (rank : 1192)
Query Neighborhood Hits	1762	Target Neighborhood Hits	439	Shared Neighborhood Hits	127
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

SRRM1_HUMAN
θ value	θ > 10 (rank : 1915)	NC score	0.095353 (rank : 1130)
Query Neighborhood Hits	1762	Target Neighborhood Hits	690	Shared Neighborhood Hits	264
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

STAC3_HUMAN
θ value	θ > 10 (rank : 1916)	NC score	0.083104 (rank : 1151)
Query Neighborhood Hits	1762	Target Neighborhood Hits	228	Shared Neighborhood Hits	77
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 1917)	NC score	0.083795 (rank : 1149)
Query Neighborhood Hits	1762	Target Neighborhood Hits	232	Shared Neighborhood Hits	76
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 1918)	NC score	0.079775 (rank : 1157)
Query Neighborhood Hits	1762	Target Neighborhood Hits	276	Shared Neighborhood Hits	94
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 1919)	NC score	0.086015 (rank : 1142)
Query Neighborhood Hits	1762	Target Neighborhood Hits	268	Shared Neighborhood Hits	95
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

TENA_HUMAN
θ value	θ > 10 (rank : 1920)	NC score	0.050110 (rank : 1321)
Query Neighborhood Hits	1762	Target Neighborhood Hits	631	Shared Neighborhood Hits	136
SwissProt Accessions	P24821, Q14583, Q15567	Gene names	TNC, HXB
Domain Architecture
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Myotendinous antigen) (Glioma- associated-extracellular matrix antigen) (GP 150-225).

TENN_MOUSE
θ value	θ > 10 (rank : 1921)	NC score	0.077024 (rank : 1169)
Query Neighborhood Hits	1762	Target Neighborhood Hits	484	Shared Neighborhood Hits	133
SwissProt Accessions	Q80Z71	Gene names	Tnn
Domain Architecture
Description	Tenascin-N precursor (TN-N).

TENR_HUMAN
θ value	θ > 10 (rank : 1922)	NC score	0.077320 (rank : 1166)
Query Neighborhood Hits	1762	Target Neighborhood Hits	526	Shared Neighborhood Hits	142
SwissProt Accessions	Q92752, Q15568, Q5R3G0	Gene names	TNR
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin).

TENR_MOUSE
θ value	θ > 10 (rank : 1923)	NC score	0.073583 (rank : 1187)
Query Neighborhood Hits	1762	Target Neighborhood Hits	531	Shared Neighborhood Hits	135
SwissProt Accessions	Q8BYI9, O88717	Gene names	Tnr
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin) (Neural recognition molecule J1-160/180).

TEX14_HUMAN
θ value	θ > 10 (rank : 1924)	NC score	0.429028 (rank : 830)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1103	Shared Neighborhood Hits	614
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
θ value	θ > 10 (rank : 1925)	NC score	0.468703 (rank : 823)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1333	Shared Neighborhood Hits	674
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TOPK_HUMAN
θ value	θ > 10 (rank : 1926)	NC score	0.583081 (rank : 798)
Query Neighborhood Hits	1762	Target Neighborhood Hits	605	Shared Neighborhood Hits	583
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

TOPK_MOUSE
θ value	θ > 10 (rank : 1927)	NC score	0.589547 (rank : 793)
Query Neighborhood Hits	1762	Target Neighborhood Hits	618	Shared Neighborhood Hits	595
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

UN13A_HUMAN
θ value	θ > 10 (rank : 1928)	NC score	0.073101 (rank : 1190)
Query Neighborhood Hits	1762	Target Neighborhood Hits	285	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_HUMAN
θ value	θ > 10 (rank : 1929)	NC score	0.068796 (rank : 1210)
Query Neighborhood Hits	1762	Target Neighborhood Hits	217	Shared Neighborhood Hits	52
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_MOUSE
θ value	θ > 10 (rank : 1930)	NC score	0.066456 (rank : 1225)
Query Neighborhood Hits	1762	Target Neighborhood Hits	210	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

VAV2_HUMAN
θ value	θ > 10 (rank : 1931)	NC score	0.071442 (rank : 1197)
Query Neighborhood Hits	1762	Target Neighborhood Hits	453	Shared Neighborhood Hits	111
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	θ > 10 (rank : 1932)	NC score	0.069038 (rank : 1209)
Query Neighborhood Hits	1762	Target Neighborhood Hits	456	Shared Neighborhood Hits	112
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	θ > 10 (rank : 1933)	NC score	0.073853 (rank : 1183)
Query Neighborhood Hits	1762	Target Neighborhood Hits	398	Shared Neighborhood Hits	102
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 1934)	NC score	0.073781 (rank : 1185)
Query Neighborhood Hits	1762	Target Neighborhood Hits	404	Shared Neighborhood Hits	107
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
θ value	θ > 10 (rank : 1935)	NC score	0.075186 (rank : 1177)
Query Neighborhood Hits	1762	Target Neighborhood Hits	452	Shared Neighborhood Hits	108
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 1936)	NC score	0.070450 (rank : 1202)
Query Neighborhood Hits	1762	Target Neighborhood Hits	430	Shared Neighborhood Hits	110
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VRK3_MOUSE
θ value	θ > 10 (rank : 1937)	NC score	0.253853 (rank : 992)
Query Neighborhood Hits	1762	Target Neighborhood Hits	342	Shared Neighborhood Hits	324
SwissProt Accessions	Q8K3G5, Q921W6	Gene names	Vrk3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

WASIP_HUMAN
θ value	θ > 10 (rank : 1938)	NC score	0.076794 (rank : 1171)
Query Neighborhood Hits	1762	Target Neighborhood Hits	458	Shared Neighborhood Hits	235
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

WASIP_MOUSE
θ value	θ > 10 (rank : 1939)	NC score	0.066804 (rank : 1221)
Query Neighborhood Hits	1762	Target Neighborhood Hits	392	Shared Neighborhood Hits	212
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

WASL_MOUSE
θ value	θ > 10 (rank : 1940)	NC score	0.059398 (rank : 1257)
Query Neighborhood Hits	1762	Target Neighborhood Hits	339	Shared Neighborhood Hits	189
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

WIRE_HUMAN
θ value	θ > 10 (rank : 1941)	NC score	0.056453 (rank : 1277)
Query Neighborhood Hits	1762	Target Neighborhood Hits	329	Shared Neighborhood Hits	172
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

WIRE_MOUSE
θ value	θ > 10 (rank : 1942)	NC score	0.050722 (rank : 1311)
Query Neighborhood Hits	1762	Target Neighborhood Hits	310	Shared Neighborhood Hits	166
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

Hits sorted by NC score

SPEG_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1762	Shared Neighborhood Hits	1762
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SPEG_MOUSE
NC score	0.986780 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1959	Shared Neighborhood Hits	1436
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

MYLK_HUMAN
NC score	0.954093 (rank : 3)	θ value	3.84914e-51 (rank : 8)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1328	Shared Neighborhood Hits	1090
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

MYLK_MOUSE
NC score	0.953467 (rank : 4)	θ value	5.02714e-51 (rank : 9)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1489	Shared Neighborhood Hits	1151
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

OBSCN_HUMAN
NC score	0.943865 (rank : 5)	θ value	1.18001e-100 (rank : 3)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1931	Shared Neighborhood Hits	1244
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

DUET_HUMAN
NC score	0.898241 (rank : 6)	θ value	9.50281e-42 (rank : 17)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1220	Shared Neighborhood Hits	1005
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

TITIN_HUMAN
NC score	0.889460 (rank : 7)	θ value	7.75577e-52 (rank : 6)
Query Neighborhood Hits	1762	Target Neighborhood Hits	2923	Shared Neighborhood Hits	1282
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

DAPK2_HUMAN
NC score	0.888155 (rank : 8)	θ value	3.48141e-52 (rank : 4)
Query Neighborhood Hits	1762	Target Neighborhood Hits	832	Shared Neighborhood Hits	814
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK2_MOUSE
NC score	0.887650 (rank : 9)	θ value	5.93839e-52 (rank : 5)
Query Neighborhood Hits	1762	Target Neighborhood Hits	834	Shared Neighborhood Hits	817
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

ST17A_HUMAN
NC score	0.886986 (rank : 10)	θ value	3.26607e-42 (rank : 15)
Query Neighborhood Hits	1762	Target Neighborhood Hits	843	Shared Neighborhood Hits	815
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

DAPK3_MOUSE
NC score	0.886752 (rank : 11)	θ value	1.72781e-51 (rank : 7)
Query Neighborhood Hits	1762	Target Neighborhood Hits	843	Shared Neighborhood Hits	813
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

ST17B_MOUSE
NC score	0.886453 (rank : 12)	θ value	7.27602e-42 (rank : 16)
Query Neighborhood Hits	1762	Target Neighborhood Hits	838	Shared Neighborhood Hits	820
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

ST17B_HUMAN
NC score	0.886255 (rank : 13)	θ value	1.2411e-41 (rank : 18)
Query Neighborhood Hits	1762	Target Neighborhood Hits	833	Shared Neighborhood Hits	816
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

DAPK3_HUMAN
NC score	0.885151 (rank : 14)	θ value	9.81109e-47 (rank : 12)
Query Neighborhood Hits	1762	Target Neighborhood Hits	945	Shared Neighborhood Hits	816
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

MYLK2_HUMAN
NC score	0.884650 (rank : 15)	θ value	2.26182e-43 (rank : 14)
Query Neighborhood Hits	1762	Target Neighborhood Hits	920	Shared Neighborhood Hits	852
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

KPSH1_HUMAN
NC score	0.879590 (rank : 16)	θ value	9.52487e-34 (rank : 24)
Query Neighborhood Hits	1762	Target Neighborhood Hits	842	Shared Neighborhood Hits	820
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KPSH1_MOUSE
NC score	0.879438 (rank : 17)	θ value	2.12192e-33 (rank : 28)
Query Neighborhood Hits	1762	Target Neighborhood Hits	839	Shared Neighborhood Hits	820
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KPSH2_HUMAN
NC score	0.879117 (rank : 18)	θ value	2.42779e-29 (rank : 42)
Query Neighborhood Hits	1762	Target Neighborhood Hits	822	Shared Neighborhood Hits	808
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

KCC1D_MOUSE
NC score	0.879052 (rank : 19)	θ value	1.46948e-34 (rank : 23)
Query Neighborhood Hits	1762	Target Neighborhood Hits	847	Shared Neighborhood Hits	826
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

DCAK3_HUMAN
NC score	0.879034 (rank : 20)	θ value	1.92365e-26 (rank : 62)
Query Neighborhood Hits	1762	Target Neighborhood Hits	888	Shared Neighborhood Hits	835
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

KCC1D_HUMAN
NC score	0.878925 (rank : 21)	θ value	1.46948e-34 (rank : 22)
Query Neighborhood Hits	1762	Target Neighborhood Hits	846	Shared Neighborhood Hits	825
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

KCC1B_MOUSE
NC score	0.878806 (rank : 22)	θ value	7.54701e-31 (rank : 34)
Query Neighborhood Hits	1762	Target Neighborhood Hits	842	Shared Neighborhood Hits	823
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

KCC1B_HUMAN
NC score	0.878610 (rank : 23)	θ value	2.42779e-29 (rank : 40)
Query Neighborhood Hits	1762	Target Neighborhood Hits	842	Shared Neighborhood Hits	823
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

KCC4_HUMAN
NC score	0.878410 (rank : 24)	θ value	2.86786e-30 (rank : 39)
Query Neighborhood Hits	1762	Target Neighborhood Hits	841	Shared Neighborhood Hits	819
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KCC1A_MOUSE
NC score	0.878278 (rank : 25)	θ value	1.28732e-30 (rank : 37)
Query Neighborhood Hits	1762	Target Neighborhood Hits	845	Shared Neighborhood Hits	824
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1A_HUMAN
NC score	0.878221 (rank : 26)	θ value	9.8567e-31 (rank : 36)
Query Neighborhood Hits	1762	Target Neighborhood Hits	846	Shared Neighborhood Hits	824
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC4_MOUSE
NC score	0.878162 (rank : 27)	θ value	1.6813e-30 (rank : 38)
Query Neighborhood Hits	1762	Target Neighborhood Hits	899	Shared Neighborhood Hits	828
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

DCAK3_MOUSE
NC score	0.878074 (rank : 28)	θ value	5.06226e-27 (rank : 58)
Query Neighborhood Hits	1762	Target Neighborhood Hits	922	Shared Neighborhood Hits	838
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

KCC2G_MOUSE
NC score	0.877937 (rank : 29)	θ value	1.24399e-33 (rank : 26)
Query Neighborhood Hits	1762	Target Neighborhood Hits	838	Shared Neighborhood Hits	815
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2G_HUMAN
NC score	0.877902 (rank : 30)	θ value	1.24399e-33 (rank : 25)
Query Neighborhood Hits	1762	Target Neighborhood Hits	841	Shared Neighborhood Hits	814
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC1G_MOUSE
NC score	0.876976 (rank : 31)	θ value	2.42779e-29 (rank : 41)
Query Neighborhood Hits	1762	Target Neighborhood Hits	851	Shared Neighborhood Hits	827
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC1G_HUMAN
NC score	0.876802 (rank : 32)	θ value	7.06379e-29 (rank : 45)
Query Neighborhood Hits	1762	Target Neighborhood Hits	850	Shared Neighborhood Hits	825
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC2D_HUMAN
NC score	0.876762 (rank : 33)	θ value	2.12192e-33 (rank : 27)
Query Neighborhood Hits	1762	Target Neighborhood Hits	830	Shared Neighborhood Hits	811
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

KCC2A_HUMAN
NC score	0.875890 (rank : 34)	θ value	3.61944e-33 (rank : 29)
Query Neighborhood Hits	1762	Target Neighborhood Hits	830	Shared Neighborhood Hits	811
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KCC2B_HUMAN
NC score	0.875829 (rank : 35)	θ value	1.0531e-32 (rank : 31)
Query Neighborhood Hits	1762	Target Neighborhood Hits	866	Shared Neighborhood Hits	823
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

KCC2A_MOUSE
NC score	0.875704 (rank : 36)	θ value	6.17384e-33 (rank : 30)
Query Neighborhood Hits	1762	Target Neighborhood Hits	829	Shared Neighborhood Hits	809
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

STK33_HUMAN
NC score	0.874439 (rank : 37)	θ value	4.73814e-25 (rank : 75)
Query Neighborhood Hits	1762	Target Neighborhood Hits	879	Shared Neighborhood Hits	823
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

KCC2B_MOUSE
NC score	0.874120 (rank : 38)	θ value	1.0531e-32 (rank : 32)
Query Neighborhood Hits	1762	Target Neighborhood Hits	841	Shared Neighborhood Hits	810
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

CHK2_MOUSE
NC score	0.873825 (rank : 39)	θ value	2.77775e-25 (rank : 72)
Query Neighborhood Hits	1762	Target Neighborhood Hits	860	Shared Neighborhood Hits	819
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

PHKG2_MOUSE
NC score	0.873424 (rank : 40)	θ value	4.73814e-25 (rank : 74)
Query Neighborhood Hits	1762	Target Neighborhood Hits	841	Shared Neighborhood Hits	823
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

PHKG2_HUMAN
NC score	0.873282 (rank : 41)	θ value	9.54697e-26 (rank : 66)
Query Neighborhood Hits	1762	Target Neighborhood Hits	839	Shared Neighborhood Hits	821
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

CHK2_HUMAN
NC score	0.872697 (rank : 42)	θ value	1.5242e-23 (rank : 91)
Query Neighborhood Hits	1762	Target Neighborhood Hits	859	Shared Neighborhood Hits	820
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

AURKC_MOUSE
NC score	0.872617 (rank : 43)	θ value	2.06002e-20 (rank : 162)
Query Neighborhood Hits	1762	Target Neighborhood Hits	844	Shared Neighborhood Hits	827
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

PLK4_HUMAN
NC score	0.872267 (rank : 44)	θ value	1.37858e-24 (rank : 80)
Query Neighborhood Hits	1762	Target Neighborhood Hits	884	Shared Neighborhood Hits	831
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PLK4_MOUSE
NC score	0.872125 (rank : 45)	θ value	3.62785e-25 (rank : 73)
Query Neighborhood Hits	1762	Target Neighborhood Hits	879	Shared Neighborhood Hits	832
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

STK6_HUMAN
NC score	0.871846 (rank : 46)	θ value	5.23862e-24 (rank : 84)
Query Neighborhood Hits	1762	Target Neighborhood Hits	916	Shared Neighborhood Hits	846
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

AURKB_MOUSE
NC score	0.871814 (rank : 47)	θ value	3.07116e-24 (rank : 83)
Query Neighborhood Hits	1762	Target Neighborhood Hits	858	Shared Neighborhood Hits	827
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

STK6_MOUSE
NC score	0.871812 (rank : 48)	θ value	1.29031e-22 (rank : 115)
Query Neighborhood Hits	1762	Target Neighborhood Hits	886	Shared Neighborhood Hits	838
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

ULK3_MOUSE
NC score	0.871676 (rank : 49)	θ value	1.02238e-19 (rank : 176)
Query Neighborhood Hits	1762	Target Neighborhood Hits	872	Shared Neighborhood Hits	824
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

AURKC_HUMAN
NC score	0.871102 (rank : 50)	θ value	3.51386e-20 (rank : 165)
Query Neighborhood Hits	1762	Target Neighborhood Hits	847	Shared Neighborhood Hits	827
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

AURKB_HUMAN
NC score	0.870880 (rank : 51)	θ value	3.07116e-24 (rank : 82)
Query Neighborhood Hits	1762	Target Neighborhood Hits	847	Shared Neighborhood Hits	826
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

ULK3_HUMAN
NC score	0.870769 (rank : 52)	θ value	2.60593e-15 (rank : 366)
Query Neighborhood Hits	1762	Target Neighborhood Hits	830	Shared Neighborhood Hits	818
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

BRSK1_HUMAN
NC score	0.870091 (rank : 53)	θ value	8.93572e-24 (rank : 88)
Query Neighborhood Hits	1762	Target Neighborhood Hits	942	Shared Neighborhood Hits	866
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

PHKG1_HUMAN
NC score	0.870086 (rank : 54)	θ value	2.12685e-25 (rank : 71)
Query Neighborhood Hits	1762	Target Neighborhood Hits	838	Shared Neighborhood Hits	819
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

SNRK_HUMAN
NC score	0.869825 (rank : 55)	θ value	5.42112e-21 (rank : 150)
Query Neighborhood Hits	1762	Target Neighborhood Hits	855	Shared Neighborhood Hits	812
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

PLK1_MOUSE
NC score	0.869734 (rank : 56)	θ value	1.42661e-21 (rank : 134)
Query Neighborhood Hits	1762	Target Neighborhood Hits	849	Shared Neighborhood Hits	822
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

PHKG1_MOUSE
NC score	0.869478 (rank : 57)	θ value	2.20094e-22 (rank : 119)
Query Neighborhood Hits	1762	Target Neighborhood Hits	840	Shared Neighborhood Hits	819
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

PLK3_MOUSE
NC score	0.869364 (rank : 58)	θ value	2.96777e-27 (rank : 56)
Query Neighborhood Hits	1762	Target Neighborhood Hits	863	Shared Neighborhood Hits	832
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

PLK3_HUMAN
NC score	0.869092 (rank : 59)	θ value	1.62847e-25 (rank : 68)
Query Neighborhood Hits	1762	Target Neighborhood Hits	865	Shared Neighborhood Hits	830
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

PLK1_HUMAN
NC score	0.869081 (rank : 60)	θ value	3.17815e-21 (rank : 139)
Query Neighborhood Hits	1762	Target Neighborhood Hits	849	Shared Neighborhood Hits	823
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

HUNK_MOUSE
NC score	0.869042 (rank : 61)	θ value	7.0802e-21 (rank : 151)
Query Neighborhood Hits	1762	Target Neighborhood Hits	874	Shared Neighborhood Hits	830
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

SNRK_MOUSE
NC score	0.868939 (rank : 62)	θ value	4.58923e-20 (rank : 170)
Query Neighborhood Hits	1762	Target Neighborhood Hits	849	Shared Neighborhood Hits	810
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

NUAK2_HUMAN
NC score	0.868849 (rank : 63)	θ value	1.99067e-23 (rank : 96)
Query Neighborhood Hits	1762	Target Neighborhood Hits	874	Shared Neighborhood Hits	830
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

HUNK_HUMAN
NC score	0.868762 (rank : 64)	θ value	1.5773e-20 (rank : 160)
Query Neighborhood Hits	1762	Target Neighborhood Hits	884	Shared Neighborhood Hits	830
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

MELK_MOUSE
NC score	0.868598 (rank : 65)	θ value	1.62847e-25 (rank : 67)
Query Neighborhood Hits	1762	Target Neighborhood Hits	860	Shared Neighborhood Hits	824
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

NUAK2_MOUSE
NC score	0.868453 (rank : 66)	θ value	6.40375e-22 (rank : 126)
Query Neighborhood Hits	1762	Target Neighborhood Hits	878	Shared Neighborhood Hits	830
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

MELK_HUMAN
NC score	0.868429 (rank : 67)	θ value	1.37858e-24 (rank : 79)
Query Neighborhood Hits	1762	Target Neighborhood Hits	847	Shared Neighborhood Hits	820
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

BRSK2_HUMAN
NC score	0.868373 (rank : 68)	θ value	2.20094e-22 (rank : 117)
Query Neighborhood Hits	1762	Target Neighborhood Hits	897	Shared Neighborhood Hits	846
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

STK11_HUMAN
NC score	0.868280 (rank : 69)	θ value	4.74913e-17 (rank : 278)
Query Neighborhood Hits	1762	Target Neighborhood Hits	831	Shared Neighborhood Hits	818
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

KKCC1_MOUSE
NC score	0.867881 (rank : 70)	θ value	2.97466e-19 (rank : 186)
Query Neighborhood Hits	1762	Target Neighborhood Hits	866	Shared Neighborhood Hits	833
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KKCC1_HUMAN
NC score	0.867651 (rank : 71)	θ value	8.65492e-19 (rank : 195)
Query Neighborhood Hits	1762	Target Neighborhood Hits	858	Shared Neighborhood Hits	829
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

PLK2_HUMAN
NC score	0.867565 (rank : 72)	θ value	1.16704e-23 (rank : 89)
Query Neighborhood Hits	1762	Target Neighborhood Hits	854	Shared Neighborhood Hits	828
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK2_MOUSE
NC score	0.867253 (rank : 73)	θ value	1.16704e-23 (rank : 90)
Query Neighborhood Hits	1762	Target Neighborhood Hits	849	Shared Neighborhood Hits	827
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

KKCC2_MOUSE
NC score	0.867045 (rank : 74)	θ value	1.24977e-17 (rank : 245)
Query Neighborhood Hits	1762	Target Neighborhood Hits	855	Shared Neighborhood Hits	820
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_HUMAN
NC score	0.866951 (rank : 75)	θ value	3.63628e-17 (rank : 264)
Query Neighborhood Hits	1762	Target Neighborhood Hits	852	Shared Neighborhood Hits	823
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

NUAK1_HUMAN
NC score	0.866926 (rank : 76)	θ value	1.29031e-22 (rank : 113)
Query Neighborhood Hits	1762	Target Neighborhood Hits	874	Shared Neighborhood Hits	830
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

NUAK1_MOUSE
NC score	0.866867 (rank : 77)	θ value	3.75424e-22 (rank : 122)
Query Neighborhood Hits	1762	Target Neighborhood Hits	881	Shared Neighborhood Hits	829
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

CHK1_MOUSE
NC score	0.866810 (rank : 78)	θ value	3.28887e-18 (rank : 218)
Query Neighborhood Hits	1762	Target Neighborhood Hits	839	Shared Neighborhood Hits	820
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

STK36_HUMAN
NC score	0.866502 (rank : 79)	θ value	4.43474e-23 (rank : 103)
Query Neighborhood Hits	1762	Target Neighborhood Hits	896	Shared Neighborhood Hits	835
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

CHK1_HUMAN
NC score	0.866334 (rank : 80)	θ value	1.92812e-18 (rank : 204)
Query Neighborhood Hits	1762	Target Neighborhood Hits	843	Shared Neighborhood Hits	818
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

MAPK2_HUMAN
NC score	0.866155 (rank : 81)	θ value	2.7842e-17 (rank : 258)
Query Neighborhood Hits	1762	Target Neighborhood Hits	844	Shared Neighborhood Hits	816
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MAPK2_MOUSE
NC score	0.865705 (rank : 82)	θ value	2.5182e-18 (rank : 213)
Query Neighborhood Hits	1762	Target Neighborhood Hits	831	Shared Neighborhood Hits	807
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

AAPK1_HUMAN
NC score	0.865659 (rank : 83)	θ value	2.97466e-19 (rank : 184)
Query Neighborhood Hits	1762	Target Neighborhood Hits	842	Shared Neighborhood Hits	828
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

DCAK1_MOUSE
NC score	0.865599 (rank : 84)	θ value	1.12775e-26 (rank : 60)
Query Neighborhood Hits	1762	Target Neighborhood Hits	867	Shared Neighborhood Hits	828
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

AAPK1_MOUSE
NC score	0.865499 (rank : 85)	θ value	2.97466e-19 (rank : 185)
Query Neighborhood Hits	1762	Target Neighborhood Hits	843	Shared Neighborhood Hits	828
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

DCAK1_HUMAN
NC score	0.865487 (rank : 86)	θ value	7.80994e-28 (rank : 53)
Query Neighborhood Hits	1762	Target Neighborhood Hits	877	Shared Neighborhood Hits	833
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DCAK2_MOUSE
NC score	0.865272 (rank : 87)	θ value	3.28125e-26 (rank : 63)
Query Neighborhood Hits	1762	Target Neighborhood Hits	858	Shared Neighborhood Hits	820
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

AAPK2_HUMAN
NC score	0.865176 (rank : 88)	θ value	1.2077e-20 (rank : 157)
Query Neighborhood Hits	1762	Target Neighborhood Hits	843	Shared Neighborhood Hits	826
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

KPCD2_HUMAN
NC score	0.864933 (rank : 89)	θ value	5.42112e-21 (rank : 149)
Query Neighborhood Hits	1762	Target Neighborhood Hits	910	Shared Neighborhood Hits	823
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

DCAK2_HUMAN
NC score	0.864853 (rank : 90)	θ value	1.12775e-26 (rank : 61)
Query Neighborhood Hits	1762	Target Neighborhood Hits	862	Shared Neighborhood Hits	820
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

SN1L1_MOUSE
NC score	0.864791 (rank : 91)	θ value	4.28545e-26 (rank : 64)
Query Neighborhood Hits	1762	Target Neighborhood Hits	895	Shared Neighborhood Hits	839
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

ULK2_MOUSE
NC score	0.864544 (rank : 92)	θ value	2.7842e-17 (rank : 262)
Query Neighborhood Hits	1762	Target Neighborhood Hits	943	Shared Neighborhood Hits	860
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

STK36_MOUSE
NC score	0.864423 (rank : 93)	θ value	1.6852e-22 (rank : 116)
Query Neighborhood Hits	1762	Target Neighborhood Hits	877	Shared Neighborhood Hits	832
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

KPCD1_HUMAN
NC score	0.864240 (rank : 94)	θ value	4.43474e-23 (rank : 98)
Query Neighborhood Hits	1762	Target Neighborhood Hits	901	Shared Neighborhood Hits	820
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

PDPK1_HUMAN
NC score	0.864229 (rank : 95)	θ value	1.02238e-19 (rank : 173)
Query Neighborhood Hits	1762	Target Neighborhood Hits	851	Shared Neighborhood Hits	828
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

SN1L1_HUMAN
NC score	0.863927 (rank : 96)	θ value	1.80048e-24 (rank : 81)
Query Neighborhood Hits	1762	Target Neighborhood Hits	911	Shared Neighborhood Hits	839
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

KPCD1_MOUSE
NC score	0.863895 (rank : 97)	θ value	7.56453e-23 (rank : 108)
Query Neighborhood Hits	1762	Target Neighborhood Hits	891	Shared Neighborhood Hits	821
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

ULK2_HUMAN
NC score	0.863856 (rank : 98)	θ value	3.63628e-17 (rank : 269)
Query Neighborhood Hits	1762	Target Neighborhood Hits	979	Shared Neighborhood Hits	872
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

PDPK1_MOUSE
NC score	0.863847 (rank : 99)	θ value	1.74391e-19 (rank : 179)
Query Neighborhood Hits	1762	Target Neighborhood Hits	852	Shared Neighborhood Hits	827
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

MAPK3_MOUSE
NC score	0.863816 (rank : 100)	θ value	8.10077e-17 (rank : 282)
Query Neighborhood Hits	1762	Target Neighborhood Hits	811	Shared Neighborhood Hits	797
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

NIM1_MOUSE
NC score	0.863776 (rank : 101)	θ value	3.07829e-16 (rank : 323)
Query Neighborhood Hits	1762	Target Neighborhood Hits	850	Shared Neighborhood Hits	825
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

ULK1_HUMAN
NC score	0.863522 (rank : 102)	θ value	2.7842e-17 (rank : 261)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1121	Shared Neighborhood Hits	920
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

TRIO_HUMAN
NC score	0.863352 (rank : 103)	θ value	3.15612e-45 (rank : 13)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1580	Shared Neighborhood Hits	1060
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

MAPK3_HUMAN
NC score	0.863301 (rank : 104)	θ value	4.74913e-17 (rank : 274)
Query Neighborhood Hits	1762	Target Neighborhood Hits	807	Shared Neighborhood Hits	789
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

MARK4_HUMAN
NC score	0.863197 (rank : 105)	θ value	1.99067e-23 (rank : 94)
Query Neighborhood Hits	1762	Target Neighborhood Hits	886	Shared Neighborhood Hits	840
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

PASK_MOUSE
NC score	0.863156 (rank : 106)	θ value	2.60593e-15 (rank : 362)
Query Neighborhood Hits	1762	Target Neighborhood Hits	867	Shared Neighborhood Hits	823
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

MARK4_MOUSE
NC score	0.863001 (rank : 107)	θ value	1.99067e-23 (rank : 95)
Query Neighborhood Hits	1762	Target Neighborhood Hits	898	Shared Neighborhood Hits	840
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

SBK1_MOUSE
NC score	0.862746 (rank : 108)	θ value	1.02475e-11 (rank : 529)
Query Neighborhood Hits	1762	Target Neighborhood Hits	824	Shared Neighborhood Hits	804
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

KPCD3_MOUSE
NC score	0.862619 (rank : 109)	θ value	1.5242e-23 (rank : 92)
Query Neighborhood Hits	1762	Target Neighborhood Hits	901	Shared Neighborhood Hits	818
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

NIM1_HUMAN
NC score	0.862535 (rank : 110)	θ value	3.07829e-16 (rank : 322)
Query Neighborhood Hits	1762	Target Neighborhood Hits	850	Shared Neighborhood Hits	823
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

PRKY_HUMAN
NC score	0.862312 (rank : 111)	θ value	9.24701e-21 (rank : 155)
Query Neighborhood Hits	1762	Target Neighborhood Hits	844	Shared Neighborhood Hits	822
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

KPCD3_HUMAN
NC score	0.862149 (rank : 112)	θ value	7.56453e-23 (rank : 109)
Query Neighborhood Hits	1762	Target Neighborhood Hits	895	Shared Neighborhood Hits	819
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

K0999_HUMAN
NC score	0.861968 (rank : 113)	θ value	1.29031e-22 (rank : 110)
Query Neighborhood Hits	1762	Target Neighborhood Hits	899	Shared Neighborhood Hits	831
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

K0999_MOUSE
NC score	0.861920 (rank : 114)	θ value	1.29031e-22 (rank : 111)
Query Neighborhood Hits	1762	Target Neighborhood Hits	931	Shared Neighborhood Hits	838
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

SN1L2_HUMAN
NC score	0.861893 (rank : 115)	θ value	1.29031e-22 (rank : 114)
Query Neighborhood Hits	1762	Target Neighborhood Hits	964	Shared Neighborhood Hits	883
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

MARK2_HUMAN
NC score	0.861791 (rank : 116)	θ value	6.84181e-24 (rank : 86)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1056	Shared Neighborhood Hits	890
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

ULK1_MOUSE
NC score	0.861390 (rank : 117)	θ value	1.38178e-16 (rank : 298)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1214	Shared Neighborhood Hits	944
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

SN1L2_MOUSE
NC score	0.861316 (rank : 118)	θ value	4.43474e-23 (rank : 102)
Query Neighborhood Hits	1762	Target Neighborhood Hits	944	Shared Neighborhood Hits	866
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

SBK1_HUMAN
NC score	0.861230 (rank : 119)	θ value	6.00763e-12 (rank : 512)
Query Neighborhood Hits	1762	Target Neighborhood Hits	828	Shared Neighborhood Hits	806
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

MARK2_MOUSE
NC score	0.861074 (rank : 120)	θ value	4.43474e-23 (rank : 99)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1018	Shared Neighborhood Hits	874
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

MARK3_MOUSE
NC score	0.860906 (rank : 121)	θ value	1.86321e-21 (rank : 136)
Query Neighborhood Hits	1762	Target Neighborhood Hits	919	Shared Neighborhood Hits	845
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

MKNK2_HUMAN
NC score	0.860634 (rank : 122)	θ value	6.20254e-17 (rank : 280)
Query Neighborhood Hits	1762	Target Neighborhood Hits	821	Shared Neighborhood Hits	803
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

KS6A2_MOUSE
NC score	0.860587 (rank : 123)	θ value	1.2049e-28 (rank : 46)
Query Neighborhood Hits	1762	Target Neighborhood Hits	858	Shared Neighborhood Hits	830
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

TSSK4_MOUSE
NC score	0.860548 (rank : 124)	θ value	4.44505e-15 (rank : 380)
Query Neighborhood Hits	1762	Target Neighborhood Hits	840	Shared Neighborhood Hits	824
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

TSSK6_MOUSE
NC score	0.860504 (rank : 125)	θ value	2.13179e-17 (rank : 252)
Query Neighborhood Hits	1762	Target Neighborhood Hits	824	Shared Neighborhood Hits	810
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

NEK3_MOUSE
NC score	0.860340 (rank : 126)	θ value	4.15078e-21 (rank : 143)
Query Neighborhood Hits	1762	Target Neighborhood Hits	854	Shared Neighborhood Hits	830
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

KS6A1_MOUSE
NC score	0.860328 (rank : 127)	θ value	5.97985e-28 (rank : 51)
Query Neighborhood Hits	1762	Target Neighborhood Hits	850	Shared Neighborhood Hits	828
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A2_HUMAN
NC score	0.860185 (rank : 128)	θ value	4.14116e-29 (rank : 44)
Query Neighborhood Hits	1762	Target Neighborhood Hits	857	Shared Neighborhood Hits	827
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

MKNK2_MOUSE
NC score	0.860120 (rank : 129)	θ value	2.7842e-17 (rank : 259)
Query Neighborhood Hits	1762	Target Neighborhood Hits	819	Shared Neighborhood Hits	801
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

KS6A6_HUMAN
NC score	0.859969 (rank : 130)	θ value	3.17079e-29 (rank : 43)
Query Neighborhood Hits	1762	Target Neighborhood Hits	853	Shared Neighborhood Hits	826
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

KS6A1_HUMAN
NC score	0.859876 (rank : 131)	θ value	1.73987e-27 (rank : 55)
Query Neighborhood Hits	1762	Target Neighborhood Hits	854	Shared Neighborhood Hits	829
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

MARK1_HUMAN
NC score	0.859856 (rank : 132)	θ value	1.29031e-22 (rank : 112)
Query Neighborhood Hits	1762	Target Neighborhood Hits	887	Shared Neighborhood Hits	829
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

MARK1_MOUSE
NC score	0.859621 (rank : 133)	θ value	1.86321e-21 (rank : 135)
Query Neighborhood Hits	1762	Target Neighborhood Hits	886	Shared Neighborhood Hits	829
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

TSSK6_HUMAN
NC score	0.859333 (rank : 134)	θ value	1.38178e-16 (rank : 297)
Query Neighborhood Hits	1762	Target Neighborhood Hits	824	Shared Neighborhood Hits	811
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

PASK_HUMAN
NC score	0.859184 (rank : 135)	θ value	1.68911e-14 (rank : 417)
Query Neighborhood Hits	1762	Target Neighborhood Hits	857	Shared Neighborhood Hits	816
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

KS6A3_MOUSE
NC score	0.858746 (rank : 136)	θ value	3.50572e-28 (rank : 50)
Query Neighborhood Hits	1762	Target Neighborhood Hits	860	Shared Neighborhood Hits	829
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_HUMAN
NC score	0.858736 (rank : 137)	θ value	3.50572e-28 (rank : 49)
Query Neighborhood Hits	1762	Target Neighborhood Hits	859	Shared Neighborhood Hits	829
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

TSSK4_HUMAN
NC score	0.858679 (rank : 138)	θ value	3.76295e-14 (rank : 432)
Query Neighborhood Hits	1762	Target Neighborhood Hits	836	Shared Neighborhood Hits	824
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

NEK3_HUMAN
NC score	0.858361 (rank : 139)	θ value	3.51386e-20 (rank : 168)
Query Neighborhood Hits	1762	Target Neighborhood Hits	865	Shared Neighborhood Hits	829
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

TSSK1_MOUSE
NC score	0.858200 (rank : 140)	θ value	7.58209e-15 (rank : 389)
Query Neighborhood Hits	1762	Target Neighborhood Hits	835	Shared Neighborhood Hits	810
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

KAPCG_HUMAN
NC score	0.858171 (rank : 141)	θ value	1.2077e-20 (rank : 158)
Query Neighborhood Hits	1762	Target Neighborhood Hits	845	Shared Neighborhood Hits	826
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

MKNK1_MOUSE
NC score	0.857508 (rank : 142)	θ value	3.51386e-20 (rank : 167)
Query Neighborhood Hits	1762	Target Neighborhood Hits	811	Shared Neighborhood Hits	794
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

TSSK2_HUMAN
NC score	0.857422 (rank : 143)	θ value	1.29331e-14 (rank : 405)
Query Neighborhood Hits	1762	Target Neighborhood Hits	826	Shared Neighborhood Hits	810
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

PAK6_HUMAN
NC score	0.857312 (rank : 144)	θ value	5.07402e-19 (rank : 191)
Query Neighborhood Hits	1762	Target Neighborhood Hits	915	Shared Neighborhood Hits	858
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

PRKX_HUMAN
NC score	0.857017 (rank : 145)	θ value	6.40375e-22 (rank : 127)
Query Neighborhood Hits	1762	Target Neighborhood Hits	847	Shared Neighborhood Hits	823
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

PRKX_MOUSE
NC score	0.856949 (rank : 146)	θ value	9.24701e-21 (rank : 154)
Query Neighborhood Hits	1762	Target Neighborhood Hits	846	Shared Neighborhood Hits	824
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

CAMKV_MOUSE
NC score	0.856832 (rank : 147)	θ value	4.15078e-21 (rank : 140)
Query Neighborhood Hits	1762	Target Neighborhood Hits	848	Shared Neighborhood Hits	802
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

TSSK3_HUMAN
NC score	0.856211 (rank : 148)	θ value	2.5182e-18 (rank : 216)
Query Neighborhood Hits	1762	Target Neighborhood Hits	806	Shared Neighborhood Hits	790
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

KS6A5_HUMAN
NC score	0.856193 (rank : 149)	θ value	2.20094e-22 (rank : 118)
Query Neighborhood Hits	1762	Target Neighborhood Hits	855	Shared Neighborhood Hits	827
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

PAK7_MOUSE
NC score	0.856028 (rank : 150)	θ value	1.09232e-21 (rank : 131)
Query Neighborhood Hits	1762	Target Neighborhood Hits	875	Shared Neighborhood Hits	832
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

PAK4_HUMAN
NC score	0.856007 (rank : 151)	θ value	4.29542e-18 (rank : 221)
Query Neighborhood Hits	1762	Target Neighborhood Hits	924	Shared Neighborhood Hits	868
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

MARK3_HUMAN
NC score	0.855978 (rank : 152)	θ value	8.10077e-17 (rank : 283)
Query Neighborhood Hits	1762	Target Neighborhood Hits	893	Shared Neighborhood Hits	829
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

TSSK3_MOUSE
NC score	0.855945 (rank : 153)	θ value	2.5182e-18 (rank : 217)
Query Neighborhood Hits	1762	Target Neighborhood Hits	806	Shared Neighborhood Hits	789
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

PAK7_HUMAN
NC score	0.855912 (rank : 154)	θ value	1.09232e-21 (rank : 130)
Query Neighborhood Hits	1762	Target Neighborhood Hits	875	Shared Neighborhood Hits	829
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

PAK2_HUMAN
NC score	0.855819 (rank : 155)	θ value	4.15078e-21 (rank : 144)
Query Neighborhood Hits	1762	Target Neighborhood Hits	862	Shared Neighborhood Hits	832
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

PAK2_MOUSE
NC score	0.855772 (rank : 156)	θ value	4.15078e-21 (rank : 145)
Query Neighborhood Hits	1762	Target Neighborhood Hits	858	Shared Neighborhood Hits	831
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

KAPCA_MOUSE
NC score	0.855211 (rank : 157)	θ value	2.7842e-17 (rank : 254)
Query Neighborhood Hits	1762	Target Neighborhood Hits	836	Shared Neighborhood Hits	823
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

TSSK1_HUMAN
NC score	0.854962 (rank : 158)	θ value	4.91457e-14 (rank : 435)
Query Neighborhood Hits	1762	Target Neighborhood Hits	840	Shared Neighborhood Hits	808
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

KAPCA_HUMAN
NC score	0.854945 (rank : 159)	θ value	1.63225e-17 (rank : 246)
Query Neighborhood Hits	1762	Target Neighborhood Hits	838	Shared Neighborhood Hits	823
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

CAMKV_HUMAN
NC score	0.854667 (rank : 160)	θ value	1.42661e-21 (rank : 132)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1084	Shared Neighborhood Hits	880
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

PAK4_MOUSE
NC score	0.854514 (rank : 161)	θ value	5.60996e-18 (rank : 225)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1098	Shared Neighborhood Hits	923
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

KAPCB_HUMAN
NC score	0.854197 (rank : 162)	θ value	1.24977e-17 (rank : 244)
Query Neighborhood Hits	1762	Target Neighborhood Hits	837	Shared Neighborhood Hits	822
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

M3K2_MOUSE
NC score	0.853926 (rank : 163)	θ value	3.63628e-17 (rank : 265)
Query Neighborhood Hits	1762	Target Neighborhood Hits	846	Shared Neighborhood Hits	823
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

KAPCB_MOUSE
NC score	0.853924 (rank : 164)	θ value	2.7842e-17 (rank : 255)
Query Neighborhood Hits	1762	Target Neighborhood Hits	836	Shared Neighborhood Hits	822
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

PAK1_HUMAN
NC score	0.853869 (rank : 165)	θ value	2.43343e-21 (rank : 138)
Query Neighborhood Hits	1762	Target Neighborhood Hits	873	Shared Neighborhood Hits	836
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

ULK4_MOUSE
NC score	0.853841 (rank : 166)	θ value	1.29331e-14 (rank : 406)
Query Neighborhood Hits	1762	Target Neighborhood Hits	793	Shared Neighborhood Hits	770
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

M3K3_MOUSE
NC score	0.853684 (rank : 167)	θ value	7.32683e-18 (rank : 233)
Query Neighborhood Hits	1762	Target Neighborhood Hits	876	Shared Neighborhood Hits	833
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K1_MOUSE
NC score	0.853644 (rank : 168)	θ value	1.09485e-13 (rank : 446)
Query Neighborhood Hits	1762	Target Neighborhood Hits	952	Shared Neighborhood Hits	851
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

PAK3_MOUSE
NC score	0.853637 (rank : 169)	θ value	1.2077e-20 (rank : 159)
Query Neighborhood Hits	1762	Target Neighborhood Hits	874	Shared Neighborhood Hits	829
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

PAK3_HUMAN
NC score	0.853573 (rank : 170)	θ value	1.86321e-21 (rank : 137)
Query Neighborhood Hits	1762	Target Neighborhood Hits	887	Shared Neighborhood Hits	833
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PAK1_MOUSE
NC score	0.853414 (rank : 171)	θ value	9.24701e-21 (rank : 153)
Query Neighborhood Hits	1762	Target Neighborhood Hits	878	Shared Neighborhood Hits	841
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

ST32A_MOUSE
NC score	0.853391 (rank : 172)	θ value	3.63628e-17 (rank : 268)
Query Neighborhood Hits	1762	Target Neighborhood Hits	833	Shared Neighborhood Hits	816
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

M3K3_HUMAN
NC score	0.853382 (rank : 173)	θ value	1.92812e-18 (rank : 208)
Query Neighborhood Hits	1762	Target Neighborhood Hits	885	Shared Neighborhood Hits	833
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

TSSK2_MOUSE
NC score	0.853283 (rank : 174)	θ value	7.09661e-13 (rank : 484)
Query Neighborhood Hits	1762	Target Neighborhood Hits	819	Shared Neighborhood Hits	800
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

KS6B1_MOUSE
NC score	0.853230 (rank : 175)	θ value	1.92812e-18 (rank : 207)
Query Neighborhood Hits	1762	Target Neighborhood Hits	849	Shared Neighborhood Hits	822
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

KS6B1_HUMAN
NC score	0.853211 (rank : 176)	θ value	1.92812e-18 (rank : 206)
Query Neighborhood Hits	1762	Target Neighborhood Hits	850	Shared Neighborhood Hits	822
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B2_HUMAN
NC score	0.852980 (rank : 177)	θ value	1.47631e-18 (rank : 202)
Query Neighborhood Hits	1762	Target Neighborhood Hits	858	Shared Neighborhood Hits	834
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

IKKA_MOUSE
NC score	0.852844 (rank : 178)	θ value	1.92812e-18 (rank : 205)
Query Neighborhood Hits	1762	Target Neighborhood Hits	867	Shared Neighborhood Hits	824
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

NEK2_HUMAN
NC score	0.852839 (rank : 179)	θ value	2.20605e-14 (rank : 424)
Query Neighborhood Hits	1762	Target Neighborhood Hits	908	Shared Neighborhood Hits	811
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

ST32A_HUMAN
NC score	0.852837 (rank : 180)	θ value	1.058e-16 (rank : 290)
Query Neighborhood Hits	1762	Target Neighborhood Hits	834	Shared Neighborhood Hits	819
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

KS6A4_MOUSE
NC score	0.852783 (rank : 181)	θ value	6.40375e-22 (rank : 124)
Query Neighborhood Hits	1762	Target Neighborhood Hits	866	Shared Neighborhood Hits	826
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

NEK2_MOUSE
NC score	0.852696 (rank : 182)	θ value	2.20605e-14 (rank : 425)
Query Neighborhood Hits	1762	Target Neighborhood Hits	876	Shared Neighborhood Hits	806
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

KS6A4_HUMAN
NC score	0.852662 (rank : 183)	θ value	2.87452e-22 (rank : 121)
Query Neighborhood Hits	1762	Target Neighborhood Hits	868	Shared Neighborhood Hits	830
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

NEK4_MOUSE
NC score	0.852627 (rank : 184)	θ value	4.74913e-17 (rank : 275)
Query Neighborhood Hits	1762	Target Neighborhood Hits	899	Shared Neighborhood Hits	834
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

ST32C_MOUSE
NC score	0.852298 (rank : 185)	θ value	2.13179e-17 (rank : 251)
Query Neighborhood Hits	1762	Target Neighborhood Hits	824	Shared Neighborhood Hits	812
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

M3K2_HUMAN
NC score	0.852293 (rank : 186)	θ value	2.35696e-16 (rank : 314)
Query Neighborhood Hits	1762	Target Neighborhood Hits	849	Shared Neighborhood Hits	824
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

AKT3_HUMAN
NC score	0.852275 (rank : 187)	θ value	1.37858e-24 (rank : 77)
Query Neighborhood Hits	1762	Target Neighborhood Hits	872	Shared Neighborhood Hits	820
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
NC score	0.852259 (rank : 188)	θ value	1.37858e-24 (rank : 78)
Query Neighborhood Hits	1762	Target Neighborhood Hits	872	Shared Neighborhood Hits	820
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

KS6B2_MOUSE
NC score	0.851604 (rank : 189)	θ value	5.07402e-19 (rank : 189)
Query Neighborhood Hits	1762	Target Neighborhood Hits	871	Shared Neighborhood Hits	838
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

NEK1_HUMAN
NC score	0.851493 (rank : 190)	θ value	1.80466e-16 (rank : 305)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1129	Shared Neighborhood Hits	845
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

AKT2_HUMAN
NC score	0.851377 (rank : 191)	θ value	1.99067e-23 (rank : 93)
Query Neighborhood Hits	1762	Target Neighborhood Hits	878	Shared Neighborhood Hits	816
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

NEK4_HUMAN
NC score	0.851377 (rank : 192)	θ value	1.058e-16 (rank : 288)
Query Neighborhood Hits	1762	Target Neighborhood Hits	883	Shared Neighborhood Hits	829
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

ST32B_MOUSE
NC score	0.851294 (rank : 193)	θ value	1.86753e-13 (rank : 455)
Query Neighborhood Hits	1762	Target Neighborhood Hits	828	Shared Neighborhood Hits	816
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

M3K6_HUMAN
NC score	0.851062 (rank : 194)	θ value	1.13037e-18 (rank : 199)
Query Neighborhood Hits	1762	Target Neighborhood Hits	889	Shared Neighborhood Hits	845
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

AKT2_MOUSE
NC score	0.850884 (rank : 195)	θ value	8.93572e-24 (rank : 87)
Query Neighborhood Hits	1762	Target Neighborhood Hits	875	Shared Neighborhood Hits	816
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

ST32B_HUMAN
NC score	0.850817 (rank : 196)	θ value	4.91457e-14 (rank : 434)
Query Neighborhood Hits	1762	Target Neighborhood Hits	830	Shared Neighborhood Hits	817
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

NEK1_MOUSE
NC score	0.850801 (rank : 197)	θ value	1.80466e-16 (rank : 306)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1311	Shared Neighborhood Hits	875
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

IKKA_HUMAN
NC score	0.850761 (rank : 198)	θ value	7.32683e-18 (rank : 229)
Query Neighborhood Hits	1762	Target Neighborhood Hits	863	Shared Neighborhood Hits	823
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

ST32C_HUMAN
NC score	0.850471 (rank : 199)	θ value	4.29542e-18 (rank : 222)
Query Neighborhood Hits	1762	Target Neighborhood Hits	832	Shared Neighborhood Hits	814
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

SGK2_MOUSE
NC score	0.850153 (rank : 200)	θ value	4.74913e-17 (rank : 276)
Query Neighborhood Hits	1762	Target Neighborhood Hits	833	Shared Neighborhood Hits	816
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

SGK1_HUMAN
NC score	0.850117 (rank : 201)	θ value	7.32683e-18 (rank : 234)
Query Neighborhood Hits	1762	Target Neighborhood Hits	848	Shared Neighborhood Hits	823
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

SGK2_HUMAN
NC score	0.849936 (rank : 202)	θ value	1.92812e-18 (rank : 210)
Query Neighborhood Hits	1762	Target Neighborhood Hits	840	Shared Neighborhood Hits	819
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

SGK1_MOUSE
NC score	0.849920 (rank : 203)	θ value	9.56915e-18 (rank : 240)
Query Neighborhood Hits	1762	Target Neighborhood Hits	848	Shared Neighborhood Hits	822
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

NEK6_HUMAN
NC score	0.849465 (rank : 204)	θ value	7.84624e-12 (rank : 518)
Query Neighborhood Hits	1762	Target Neighborhood Hits	848	Shared Neighborhood Hits	827
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

KS6A5_MOUSE
NC score	0.849427 (rank : 205)	θ value	2.97466e-19 (rank : 187)
Query Neighborhood Hits	1762	Target Neighborhood Hits	854	Shared Neighborhood Hits	824
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

NEK6_MOUSE
NC score	0.849319 (rank : 206)	θ value	7.84624e-12 (rank : 519)
Query Neighborhood Hits	1762	Target Neighborhood Hits	851	Shared Neighborhood Hits	827
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

RK_MOUSE
NC score	0.849206 (rank : 207)	θ value	1.47631e-18 (rank : 203)
Query Neighborhood Hits	1762	Target Neighborhood Hits	829	Shared Neighborhood Hits	814
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

IKKE_HUMAN
NC score	0.848850 (rank : 208)	θ value	1.80466e-16 (rank : 300)
Query Neighborhood Hits	1762	Target Neighborhood Hits	837	Shared Neighborhood Hits	800
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

IKKB_HUMAN
NC score	0.848617 (rank : 209)	θ value	4.74913e-17 (rank : 271)
Query Neighborhood Hits	1762	Target Neighborhood Hits	980	Shared Neighborhood Hits	826
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKB_MOUSE
NC score	0.848265 (rank : 210)	θ value	2.7842e-17 (rank : 253)
Query Neighborhood Hits	1762	Target Neighborhood Hits	984	Shared Neighborhood Hits	824
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

MAPK5_MOUSE
NC score	0.847798 (rank : 211)	θ value	6.62687e-19 (rank : 192)
Query Neighborhood Hits	1762	Target Neighborhood Hits	799	Shared Neighborhood Hits	781
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

NEK11_MOUSE
NC score	0.847557 (rank : 212)	θ value	9.90251e-15 (rank : 395)
Query Neighborhood Hits	1762	Target Neighborhood Hits	875	Shared Neighborhood Hits	823
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

M3K5_MOUSE
NC score	0.847477 (rank : 213)	θ value	3.63628e-17 (rank : 267)
Query Neighborhood Hits	1762	Target Neighborhood Hits	867	Shared Neighborhood Hits	824
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

IKKE_MOUSE
NC score	0.847445 (rank : 214)	θ value	3.07829e-16 (rank : 321)
Query Neighborhood Hits	1762	Target Neighborhood Hits	848	Shared Neighborhood Hits	801
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

AKT1_HUMAN
NC score	0.847408 (rank : 215)	θ value	7.56453e-23 (rank : 105)
Query Neighborhood Hits	1762	Target Neighborhood Hits	885	Shared Neighborhood Hits	815
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

M3K5_HUMAN
NC score	0.847381 (rank : 216)	θ value	3.63628e-17 (rank : 266)
Query Neighborhood Hits	1762	Target Neighborhood Hits	868	Shared Neighborhood Hits	822
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K4_HUMAN
NC score	0.847248 (rank : 217)	θ value	1.09485e-13 (rank : 447)
Query Neighborhood Hits	1762	Target Neighborhood Hits	911	Shared Neighborhood Hits	833
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

AKT1_MOUSE
NC score	0.847121 (rank : 218)	θ value	7.56453e-23 (rank : 106)
Query Neighborhood Hits	1762	Target Neighborhood Hits	878	Shared Neighborhood Hits	814
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

E2AK2_MOUSE
NC score	0.846980 (rank : 219)	θ value	8.38298e-14 (rank : 440)
Query Neighborhood Hits	1762	Target Neighborhood Hits	864	Shared Neighborhood Hits	825
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

NEK7_HUMAN
NC score	0.846755 (rank : 220)	θ value	6.41864e-14 (rank : 437)
Query Neighborhood Hits	1762	Target Neighborhood Hits	846	Shared Neighborhood Hits	826
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK7_MOUSE
NC score	0.846687 (rank : 221)	θ value	1.42992e-13 (rank : 452)
Query Neighborhood Hits	1762	Target Neighborhood Hits	847	Shared Neighborhood Hits	827
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

CDKL3_MOUSE
NC score	0.846657 (rank : 222)	θ value	2.35696e-16 (rank : 312)
Query Neighborhood Hits	1762	Target Neighborhood Hits	857	Shared Neighborhood Hits	826
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

M3K15_HUMAN
NC score	0.846528 (rank : 223)	θ value	7.32683e-18 (rank : 232)
Query Neighborhood Hits	1762	Target Neighborhood Hits	914	Shared Neighborhood Hits	829
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

MAPK5_HUMAN
NC score	0.846456 (rank : 224)	θ value	5.07402e-19 (rank : 190)
Query Neighborhood Hits	1762	Target Neighborhood Hits	795	Shared Neighborhood Hits	777
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

RK_HUMAN
NC score	0.846354 (rank : 225)	θ value	8.10077e-17 (rank : 284)
Query Neighborhood Hits	1762	Target Neighborhood Hits	835	Shared Neighborhood Hits	816
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

TBK1_HUMAN
NC score	0.846340 (rank : 226)	θ value	1.99529e-15 (rank : 359)
Query Neighborhood Hits	1762	Target Neighborhood Hits	861	Shared Neighborhood Hits	792
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

M3K4_MOUSE
NC score	0.846257 (rank : 227)	θ value	6.41864e-14 (rank : 436)
Query Neighborhood Hits	1762	Target Neighborhood Hits	924	Shared Neighborhood Hits	836
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

TBK1_MOUSE
NC score	0.845993 (rank : 228)	θ value	2.60593e-15 (rank : 365)
Query Neighborhood Hits	1762	Target Neighborhood Hits	893	Shared Neighborhood Hits	794
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

CDKL3_HUMAN
NC score	0.845817 (rank : 229)	θ value	4.02038e-16 (rank : 325)
Query Neighborhood Hits	1762	Target Neighborhood Hits	853	Shared Neighborhood Hits	826
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

M3K14_HUMAN
NC score	0.845578 (rank : 230)	θ value	3.52202e-12 (rank : 502)
Query Neighborhood Hits	1762	Target Neighborhood Hits	887	Shared Neighborhood Hits	840
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

SGK3_MOUSE
NC score	0.844655 (rank : 231)	θ value	6.62687e-19 (rank : 193)
Query Neighborhood Hits	1762	Target Neighborhood Hits	882	Shared Neighborhood Hits	817
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

SGK3_HUMAN
NC score	0.844223 (rank : 232)	θ value	4.74913e-17 (rank : 277)
Query Neighborhood Hits	1762	Target Neighborhood Hits	877	Shared Neighborhood Hits	817
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

NEK11_HUMAN
NC score	0.844174 (rank : 233)	θ value	3.76295e-14 (rank : 431)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1043	Shared Neighborhood Hits	841
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK8_MOUSE
NC score	0.843568 (rank : 234)	θ value	1.80466e-16 (rank : 308)
Query Neighborhood Hits	1762	Target Neighborhood Hits	872	Shared Neighborhood Hits	825
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

CDKL5_HUMAN
NC score	0.843524 (rank : 235)	θ value	1.47631e-18 (rank : 201)
Query Neighborhood Hits	1762	Target Neighborhood Hits	967	Shared Neighborhood Hits	856
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

NEK8_HUMAN
NC score	0.843509 (rank : 236)	θ value	1.80466e-16 (rank : 307)
Query Neighborhood Hits	1762	Target Neighborhood Hits	872	Shared Neighborhood Hits	825
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

TTK_HUMAN
NC score	0.843308 (rank : 237)	θ value	3.40345e-15 (rank : 374)
Query Neighborhood Hits	1762	Target Neighborhood Hits	816	Shared Neighborhood Hits	776
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

KGP2_HUMAN
NC score	0.843304 (rank : 238)	θ value	3.63628e-17 (rank : 263)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1023	Shared Neighborhood Hits	832
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

M3K14_MOUSE
NC score	0.843293 (rank : 239)	θ value	7.09661e-13 (rank : 480)
Query Neighborhood Hits	1762	Target Neighborhood Hits	889	Shared Neighborhood Hits	828
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

CDKL1_MOUSE
NC score	0.843277 (rank : 240)	θ value	8.36355e-22 (rank : 128)
Query Neighborhood Hits	1762	Target Neighborhood Hits	829	Shared Neighborhood Hits	815
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

KGP1A_HUMAN
NC score	0.843127 (rank : 241)	θ value	5.42112e-21 (rank : 146)
Query Neighborhood Hits	1762	Target Neighborhood Hits	901	Shared Neighborhood Hits	821
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP2_MOUSE
NC score	0.842970 (rank : 242)	θ value	2.7842e-17 (rank : 256)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1029	Shared Neighborhood Hits	833
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KGP1B_MOUSE
NC score	0.842736 (rank : 243)	θ value	5.42112e-21 (rank : 148)
Query Neighborhood Hits	1762	Target Neighborhood Hits	922	Shared Neighborhood Hits	823
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_HUMAN
NC score	0.842673 (rank : 244)	θ value	5.42112e-21 (rank : 147)
Query Neighborhood Hits	1762	Target Neighborhood Hits	921	Shared Neighborhood Hits	823
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

CDKL1_HUMAN
NC score	0.842542 (rank : 245)	θ value	4.15078e-21 (rank : 141)
Query Neighborhood Hits	1762	Target Neighborhood Hits	830	Shared Neighborhood Hits	815
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

GRK5_MOUSE
NC score	0.842470 (rank : 246)	θ value	2.5182e-18 (rank : 212)
Query Neighborhood Hits	1762	Target Neighborhood Hits	823	Shared Neighborhood Hits	805
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

CDKL4_MOUSE
NC score	0.842365 (rank : 247)	θ value	1.42661e-21 (rank : 133)
Query Neighborhood Hits	1762	Target Neighborhood Hits	833	Shared Neighborhood Hits	816
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

GRK5_HUMAN
NC score	0.842129 (rank : 248)	θ value	2.5182e-18 (rank : 211)
Query Neighborhood Hits	1762	Target Neighborhood Hits	819	Shared Neighborhood Hits	805
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK6_HUMAN
NC score	0.842129 (rank : 249)	θ value	9.56915e-18 (rank : 236)
Query Neighborhood Hits	1762	Target Neighborhood Hits	823	Shared Neighborhood Hits	812
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

PKN2_MOUSE
NC score	0.842023 (rank : 250)	θ value	9.56915e-18 (rank : 239)
Query Neighborhood Hits	1762	Target Neighborhood Hits	899	Shared Neighborhood Hits	822
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN2_HUMAN
NC score	0.841773 (rank : 251)	θ value	9.56915e-18 (rank : 238)
Query Neighborhood Hits	1762	Target Neighborhood Hits	892	Shared Neighborhood Hits	823
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

TTK_MOUSE
NC score	0.841577 (rank : 252)	θ value	3.40345e-15 (rank : 375)
Query Neighborhood Hits	1762	Target Neighborhood Hits	803	Shared Neighborhood Hits	757
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

YSK4_HUMAN
NC score	0.841509 (rank : 253)	θ value	1.68911e-14 (rank : 419)
Query Neighborhood Hits	1762	Target Neighborhood Hits	921	Shared Neighborhood Hits	827
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

GRK6_MOUSE
NC score	0.841354 (rank : 254)	θ value	2.13179e-17 (rank : 248)
Query Neighborhood Hits	1762	Target Neighborhood Hits	820	Shared Neighborhood Hits	811
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

PIM2_MOUSE
NC score	0.841107 (rank : 255)	θ value	6.21693e-09 (rank : 631)
Query Neighborhood Hits	1762	Target Neighborhood Hits	809	Shared Neighborhood Hits	793
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

STK3_MOUSE
NC score	0.841070 (rank : 256)	θ value	9.56915e-18 (rank : 241)
Query Neighborhood Hits	1762	Target Neighborhood Hits	869	Shared Neighborhood Hits	821
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

STK4_MOUSE
NC score	0.840958 (rank : 257)	θ value	3.88503e-19 (rank : 188)
Query Neighborhood Hits	1762	Target Neighborhood Hits	873	Shared Neighborhood Hits	821
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

STK4_HUMAN
NC score	0.840938 (rank : 258)	θ value	8.65492e-19 (rank : 197)
Query Neighborhood Hits	1762	Target Neighborhood Hits	870	Shared Neighborhood Hits	821
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

PKN3_HUMAN
NC score	0.840833 (rank : 259)	θ value	8.95645e-16 (rank : 341)
Query Neighborhood Hits	1762	Target Neighborhood Hits	893	Shared Neighborhood Hits	832
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

STK3_HUMAN
NC score	0.840778 (rank : 260)	θ value	7.32683e-18 (rank : 235)
Query Neighborhood Hits	1762	Target Neighborhood Hits	861	Shared Neighborhood Hits	822
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

PDK1L_HUMAN
NC score	0.840668 (rank : 261)	θ value	2.13673e-09 (rank : 604)
Query Neighborhood Hits	1762	Target Neighborhood Hits	821	Shared Neighborhood Hits	802
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PDK1L_MOUSE
NC score	0.840523 (rank : 262)	θ value	2.13673e-09 (rank : 605)
Query Neighborhood Hits	1762	Target Neighborhood Hits	821	Shared Neighborhood Hits	803
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

MAST3_HUMAN
NC score	0.840313 (rank : 263)	θ value	1.29331e-14 (rank : 402)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1128	Shared Neighborhood Hits	923
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

CDKL2_MOUSE
NC score	0.840203 (rank : 264)	θ value	4.74913e-17 (rank : 270)
Query Neighborhood Hits	1762	Target Neighborhood Hits	854	Shared Neighborhood Hits	823
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

PKN3_MOUSE
NC score	0.840176 (rank : 265)	θ value	1.02238e-19 (rank : 174)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1009	Shared Neighborhood Hits	851
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

CDKL4_HUMAN
NC score	0.840112 (rank : 266)	θ value	8.36355e-22 (rank : 129)
Query Neighborhood Hits	1762	Target Neighborhood Hits	828	Shared Neighborhood Hits	812
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

PIM2_HUMAN
NC score	0.839896 (rank : 267)	θ value	1.25267e-09 (rank : 595)
Query Neighborhood Hits	1762	Target Neighborhood Hits	808	Shared Neighborhood Hits	793
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

KPCT_MOUSE
NC score	0.839737 (rank : 268)	θ value	8.95645e-16 (rank : 339)
Query Neighborhood Hits	1762	Target Neighborhood Hits	895	Shared Neighborhood Hits	822
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

PKN1_MOUSE
NC score	0.839587 (rank : 269)	θ value	1.13037e-18 (rank : 200)
Query Neighborhood Hits	1762	Target Neighborhood Hits	888	Shared Neighborhood Hits	824
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

CDKL2_HUMAN
NC score	0.839474 (rank : 270)	θ value	1.16975e-15 (rank : 347)
Query Neighborhood Hits	1762	Target Neighborhood Hits	838	Shared Neighborhood Hits	818
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

PKN1_HUMAN
NC score	0.839356 (rank : 271)	θ value	2.5182e-18 (rank : 214)
Query Neighborhood Hits	1762	Target Neighborhood Hits	886	Shared Neighborhood Hits	832
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

KPCT_HUMAN
NC score	0.839341 (rank : 272)	θ value	6.85773e-16 (rank : 333)
Query Neighborhood Hits	1762	Target Neighborhood Hits	897	Shared Neighborhood Hits	824
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPCI_MOUSE
NC score	0.838914 (rank : 273)	θ value	1.13037e-18 (rank : 198)
Query Neighborhood Hits	1762	Target Neighborhood Hits	888	Shared Neighborhood Hits	824
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

M3K8_MOUSE
NC score	0.838789 (rank : 274)	θ value	1.74796e-11 (rank : 535)
Query Neighborhood Hits	1762	Target Neighborhood Hits	815	Shared Neighborhood Hits	793
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

M3K8_HUMAN
NC score	0.838598 (rank : 275)	θ value	1.74796e-11 (rank : 534)
Query Neighborhood Hits	1762	Target Neighborhood Hits	807	Shared Neighborhood Hits	793
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

KPCI_HUMAN
NC score	0.838451 (rank : 276)	θ value	4.74913e-17 (rank : 273)
Query Neighborhood Hits	1762	Target Neighborhood Hits	885	Shared Neighborhood Hits	824
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

GRK4_HUMAN
NC score	0.838260 (rank : 277)	θ value	4.29542e-18 (rank : 220)
Query Neighborhood Hits	1762	Target Neighborhood Hits	822	Shared Neighborhood Hits	805
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

PIM1_HUMAN
NC score	0.838258 (rank : 278)	θ value	2.13673e-09 (rank : 606)
Query Neighborhood Hits	1762	Target Neighborhood Hits	797	Shared Neighborhood Hits	781
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

PIM1_MOUSE
NC score	0.837462 (rank : 279)	θ value	2.52405e-10 (rank : 570)
Query Neighborhood Hits	1762	Target Neighborhood Hits	787	Shared Neighborhood Hits	770
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

PIM3_HUMAN
NC score	0.837377 (rank : 280)	θ value	1.38499e-08 (rank : 650)
Query Neighborhood Hits	1762	Target Neighborhood Hits	789	Shared Neighborhood Hits	776
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

STK24_HUMAN
NC score	0.837236 (rank : 281)	θ value	2.5182e-18 (rank : 215)
Query Neighborhood Hits	1762	Target Neighborhood Hits	853	Shared Neighborhood Hits	826
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

MAST2_MOUSE
NC score	0.837021 (rank : 282)	θ value	5.8054e-15 (rank : 383)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1110	Shared Neighborhood Hits	890
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

OXSR1_HUMAN
NC score	0.836831 (rank : 283)	θ value	3.18553e-13 (rank : 468)
Query Neighborhood Hits	1762	Target Neighborhood Hits	874	Shared Neighborhood Hits	829
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

OXSR1_MOUSE
NC score	0.836439 (rank : 284)	θ value	2.0648e-12 (rank : 500)
Query Neighborhood Hits	1762	Target Neighborhood Hits	865	Shared Neighborhood Hits	827
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

STK24_MOUSE
NC score	0.836407 (rank : 285)	θ value	4.29542e-18 (rank : 223)
Query Neighborhood Hits	1762	Target Neighborhood Hits	856	Shared Neighborhood Hits	827
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

GRK4_MOUSE
NC score	0.836186 (rank : 286)	θ value	1.24977e-17 (rank : 243)
Query Neighborhood Hits	1762	Target Neighborhood Hits	808	Shared Neighborhood Hits	798
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

MST4_MOUSE
NC score	0.836076 (rank : 287)	θ value	1.80466e-16 (rank : 304)
Query Neighborhood Hits	1762	Target Neighborhood Hits	860	Shared Neighborhood Hits	822
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

MST4_HUMAN
NC score	0.836025 (rank : 288)	θ value	1.80466e-16 (rank : 303)
Query Neighborhood Hits	1762	Target Neighborhood Hits	852	Shared Neighborhood Hits	822
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

E2AK2_HUMAN
NC score	0.835872 (rank : 289)	θ value	1.74796e-11 (rank : 533)
Query Neighborhood Hits	1762	Target Neighborhood Hits	856	Shared Neighborhood Hits	815
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

MAST2_HUMAN
NC score	0.835833 (rank : 290)	θ value	4.44505e-15 (rank : 377)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1189	Shared Neighborhood Hits	914
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

CDC2_HUMAN
NC score	0.835784 (rank : 291)	θ value	4.29542e-18 (rank : 219)
Query Neighborhood Hits	1762	Target Neighborhood Hits	842	Shared Neighborhood Hits	821
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

STK35_HUMAN
NC score	0.835702 (rank : 292)	θ value	1.80886e-08 (rank : 657)
Query Neighborhood Hits	1762	Target Neighborhood Hits	825	Shared Neighborhood Hits	806
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

GRK7_HUMAN
NC score	0.835653 (rank : 293)	θ value	2.13673e-09 (rank : 602)
Query Neighborhood Hits	1762	Target Neighborhood Hits	820	Shared Neighborhood Hits	806
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

KPCL_MOUSE
NC score	0.835594 (rank : 294)	θ value	2.35696e-16 (rank : 313)
Query Neighborhood Hits	1762	Target Neighborhood Hits	891	Shared Neighborhood Hits	811
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

STK39_MOUSE
NC score	0.835444 (rank : 295)	θ value	5.08577e-11 (rank : 546)
Query Neighborhood Hits	1762	Target Neighborhood Hits	915	Shared Neighborhood Hits	839
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

MP2K2_HUMAN
NC score	0.835389 (rank : 296)	θ value	1.68911e-14 (rank : 415)
Query Neighborhood Hits	1762	Target Neighborhood Hits	830	Shared Neighborhood Hits	815
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

PIM3_MOUSE
NC score	0.835326 (rank : 297)	θ value	1.17247e-07 (rank : 697)
Query Neighborhood Hits	1762	Target Neighborhood Hits	783	Shared Neighborhood Hits	770
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

CDK3_MOUSE
NC score	0.834981 (rank : 298)	θ value	1.68911e-14 (rank : 408)
Query Neighborhood Hits	1762	Target Neighborhood Hits	829	Shared Neighborhood Hits	813
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

STK39_HUMAN
NC score	0.834925 (rank : 299)	θ value	5.08577e-11 (rank : 545)
Query Neighborhood Hits	1762	Target Neighborhood Hits	882	Shared Neighborhood Hits	831
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

CDC2_MOUSE
NC score	0.834807 (rank : 300)	θ value	6.20254e-17 (rank : 279)
Query Neighborhood Hits	1762	Target Neighborhood Hits	838	Shared Neighborhood Hits	820
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

STK25_HUMAN
NC score	0.834241 (rank : 301)	θ value	1.68911e-14 (rank : 418)
Query Neighborhood Hits	1762	Target Neighborhood Hits	853	Shared Neighborhood Hits	822
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

KPCZ_MOUSE
NC score	0.834219 (rank : 302)	θ value	4.02038e-16 (rank : 327)
Query Neighborhood Hits	1762	Target Neighborhood Hits	882	Shared Neighborhood Hits	819
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KPCZ_HUMAN
NC score	0.834197 (rank : 303)	θ value	1.80466e-16 (rank : 301)
Query Neighborhood Hits	1762	Target Neighborhood Hits	884	Shared Neighborhood Hits	820
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

MP2K2_MOUSE
NC score	0.834084 (rank : 304)	θ value	4.44505e-15 (rank : 379)
Query Neighborhood Hits	1762	Target Neighborhood Hits	828	Shared Neighborhood Hits	814
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

KPCD_HUMAN
NC score	0.833896 (rank : 305)	θ value	2.20605e-14 (rank : 420)
Query Neighborhood Hits	1762	Target Neighborhood Hits	900	Shared Neighborhood Hits	818
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

STK25_MOUSE
NC score	0.833862 (rank : 306)	θ value	2.20605e-14 (rank : 427)
Query Neighborhood Hits	1762	Target Neighborhood Hits	851	Shared Neighborhood Hits	822
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

PMYT1_MOUSE
NC score	0.833696 (rank : 307)	θ value	4.59992e-12 (rank : 508)
Query Neighborhood Hits	1762	Target Neighborhood Hits	910	Shared Neighborhood Hits	837
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

MP2K1_HUMAN
NC score	0.833690 (rank : 308)	θ value	7.09661e-13 (rank : 482)
Query Neighborhood Hits	1762	Target Neighborhood Hits	826	Shared Neighborhood Hits	813
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_MOUSE
NC score	0.833551 (rank : 309)	θ value	7.09661e-13 (rank : 483)
Query Neighborhood Hits	1762	Target Neighborhood Hits	826	Shared Neighborhood Hits	813
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MAST1_HUMAN
NC score	0.833543 (rank : 310)	θ value	4.91457e-14 (rank : 433)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1146	Shared Neighborhood Hits	902
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

KPCL_HUMAN
NC score	0.833321 (rank : 311)	θ value	4.02038e-16 (rank : 326)
Query Neighborhood Hits	1762	Target Neighborhood Hits	887	Shared Neighborhood Hits	811
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KPCE_MOUSE
NC score	0.833279 (rank : 312)	θ value	5.8054e-15 (rank : 382)
Query Neighborhood Hits	1762	Target Neighborhood Hits	906	Shared Neighborhood Hits	820
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCE_HUMAN
NC score	0.833221 (rank : 313)	θ value	8.95645e-16 (rank : 338)
Query Neighborhood Hits	1762	Target Neighborhood Hits	906	Shared Neighborhood Hits	818
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

M4K3_HUMAN
NC score	0.833176 (rank : 314)	θ value	8.38298e-14 (rank : 442)
Query Neighborhood Hits	1762	Target Neighborhood Hits	857	Shared Neighborhood Hits	821
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

MAST1_MOUSE
NC score	0.833018 (rank : 315)	θ value	2.20605e-14 (rank : 423)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1123	Shared Neighborhood Hits	886
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

KPCD_MOUSE
NC score	0.832820 (rank : 316)	θ value	1.52774e-15 (rank : 349)
Query Neighborhood Hits	1762	Target Neighborhood Hits	888	Shared Neighborhood Hits	816
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

M4K1_HUMAN
NC score	0.832553 (rank : 317)	θ value	6.85773e-16 (rank : 335)
Query Neighborhood Hits	1762	Target Neighborhood Hits	884	Shared Neighborhood Hits	831
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

CDK3_HUMAN
NC score	0.832182 (rank : 318)	θ value	1.38178e-16 (rank : 292)
Query Neighborhood Hits	1762	Target Neighborhood Hits	843	Shared Neighborhood Hits	823
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

ARBK1_HUMAN
NC score	0.831597 (rank : 319)	θ value	1.68911e-14 (rank : 407)
Query Neighborhood Hits	1762	Target Neighborhood Hits	859	Shared Neighborhood Hits	812
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

MP2K5_MOUSE
NC score	0.831477 (rank : 320)	θ value	1.02475e-11 (rank : 527)
Query Neighborhood Hits	1762	Target Neighborhood Hits	840	Shared Neighborhood Hits	821
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

NEK9_HUMAN
NC score	0.831423 (rank : 321)	θ value	2.69671e-12 (rank : 501)
Query Neighborhood Hits	1762	Target Neighborhood Hits	900	Shared Neighborhood Hits	831
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

MAST4_HUMAN
NC score	0.831260 (rank : 322)	θ value	1.68911e-14 (rank : 413)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1804	Shared Neighborhood Hits	1083
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

ICK_MOUSE
NC score	0.831028 (rank : 323)	θ value	1.68911e-14 (rank : 411)
Query Neighborhood Hits	1762	Target Neighborhood Hits	860	Shared Neighborhood Hits	827
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

ARBK2_HUMAN
NC score	0.831022 (rank : 324)	θ value	8.38298e-14 (rank : 439)
Query Neighborhood Hits	1762	Target Neighborhood Hits	849	Shared Neighborhood Hits	812
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

NEK9_MOUSE
NC score	0.830981 (rank : 325)	θ value	3.52202e-12 (rank : 505)
Query Neighborhood Hits	1762	Target Neighborhood Hits	890	Shared Neighborhood Hits	830
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

CDK2_HUMAN
NC score	0.830863 (rank : 326)	θ value	7.32683e-18 (rank : 228)
Query Neighborhood Hits	1762	Target Neighborhood Hits	832	Shared Neighborhood Hits	816
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

M4K1_MOUSE
NC score	0.830857 (rank : 327)	θ value	2.20605e-14 (rank : 422)
Query Neighborhood Hits	1762	Target Neighborhood Hits	858	Shared Neighborhood Hits	827
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

ARBK1_MOUSE
NC score	0.830742 (rank : 328)	θ value	1.29331e-14 (rank : 397)
Query Neighborhood Hits	1762	Target Neighborhood Hits	849	Shared Neighborhood Hits	811
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

ST38L_HUMAN
NC score	0.830605 (rank : 329)	θ value	1.74391e-19 (rank : 180)
Query Neighborhood Hits	1762	Target Neighborhood Hits	824	Shared Neighborhood Hits	790
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

ICK_HUMAN
NC score	0.830324 (rank : 330)	θ value	1.29331e-14 (rank : 398)
Query Neighborhood Hits	1762	Target Neighborhood Hits	867	Shared Neighborhood Hits	828
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

MAK_MOUSE
NC score	0.830088 (rank : 331)	θ value	4.02038e-16 (rank : 329)
Query Neighborhood Hits	1762	Target Neighborhood Hits	873	Shared Neighborhood Hits	825
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

M4K2_MOUSE
NC score	0.829908 (rank : 332)	θ value	5.43371e-13 (rank : 476)
Query Neighborhood Hits	1762	Target Neighborhood Hits	843	Shared Neighborhood Hits	813
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

M4K2_HUMAN
NC score	0.829752 (rank : 333)	θ value	9.26847e-13 (rank : 486)
Query Neighborhood Hits	1762	Target Neighborhood Hits	850	Shared Neighborhood Hits	819
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

CSKP_MOUSE
NC score	0.829742 (rank : 334)	θ value	3.87602e-27 (rank : 57)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1027	Shared Neighborhood Hits	813
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

PMYT1_HUMAN
NC score	0.829736 (rank : 335)	θ value	8.38298e-14 (rank : 444)
Query Neighborhood Hits	1762	Target Neighborhood Hits	814	Shared Neighborhood Hits	799
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

PFTK1_MOUSE
NC score	0.829591 (rank : 336)	θ value	4.02038e-16 (rank : 330)
Query Neighborhood Hits	1762	Target Neighborhood Hits	835	Shared Neighborhood Hits	811
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PFTK1_HUMAN
NC score	0.829524 (rank : 337)	θ value	1.058e-16 (rank : 289)
Query Neighborhood Hits	1762	Target Neighborhood Hits	834	Shared Neighborhood Hits	812
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

CDK7_MOUSE
NC score	0.829469 (rank : 338)	θ value	3.07829e-16 (rank : 320)
Query Neighborhood Hits	1762	Target Neighborhood Hits	835	Shared Neighborhood Hits	813
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

CDK7_HUMAN
NC score	0.829319 (rank : 339)	θ value	3.07829e-16 (rank : 319)
Query Neighborhood Hits	1762	Target Neighborhood Hits	833	Shared Neighborhood Hits	812
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

STK38_HUMAN
NC score	0.829030 (rank : 340)	θ value	4.02038e-16 (rank : 332)
Query Neighborhood Hits	1762	Target Neighborhood Hits	840	Shared Neighborhood Hits	795
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK38_MOUSE
NC score	0.828977 (rank : 341)	θ value	1.38178e-16 (rank : 296)
Query Neighborhood Hits	1762	Target Neighborhood Hits	838	Shared Neighborhood Hits	795
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

MAK_HUMAN
NC score	0.828824 (rank : 342)	θ value	8.95645e-16 (rank : 340)
Query Neighborhood Hits	1762	Target Neighborhood Hits	857	Shared Neighborhood Hits	819
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

TLK1_MOUSE
NC score	0.828625 (rank : 343)	θ value	9.26847e-13 (rank : 491)
Query Neighborhood Hits	1762	Target Neighborhood Hits	947	Shared Neighborhood Hits	770
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

TLK1_HUMAN
NC score	0.828544 (rank : 344)	θ value	9.26847e-13 (rank : 490)
Query Neighborhood Hits	1762	Target Neighborhood Hits	967	Shared Neighborhood Hits	771
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

CDK2_MOUSE
NC score	0.828320 (rank : 345)	θ value	2.35696e-16 (rank : 311)
Query Neighborhood Hits	1762	Target Neighborhood Hits	828	Shared Neighborhood Hits	814
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

MASTL_HUMAN
NC score	0.827974 (rank : 346)	θ value	6.87365e-08 (rank : 679)
Query Neighborhood Hits	1762	Target Neighborhood Hits	894	Shared Neighborhood Hits	824
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

MASTL_MOUSE
NC score	0.827671 (rank : 347)	θ value	8.97725e-08 (rank : 687)
Query Neighborhood Hits	1762	Target Neighborhood Hits	862	Shared Neighborhood Hits	825
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

TLK2_HUMAN
NC score	0.827498 (rank : 348)	θ value	6.00763e-12 (rank : 513)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1044	Shared Neighborhood Hits	790
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

CSKP_HUMAN
NC score	0.827480 (rank : 349)	θ value	1.73987e-27 (rank : 54)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1022	Shared Neighborhood Hits	813
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

M4K5_MOUSE
NC score	0.826947 (rank : 350)	θ value	1.68911e-14 (rank : 412)
Query Neighborhood Hits	1762	Target Neighborhood Hits	839	Shared Neighborhood Hits	810
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

PCTK3_MOUSE
NC score	0.826529 (rank : 351)	θ value	7.58209e-15 (rank : 387)
Query Neighborhood Hits	1762	Target Neighborhood Hits	834	Shared Neighborhood Hits	811
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

CDK5_HUMAN
NC score	0.825920 (rank : 352)	θ value	1.68911e-14 (rank : 409)
Query Neighborhood Hits	1762	Target Neighborhood Hits	826	Shared Neighborhood Hits	812
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

MP2K5_HUMAN
NC score	0.825887 (rank : 353)	θ value	3.29651e-10 (rank : 574)
Query Neighborhood Hits	1762	Target Neighborhood Hits	837	Shared Neighborhood Hits	817
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

CDK5_MOUSE
NC score	0.825783 (rank : 354)	θ value	1.68911e-14 (rank : 410)
Query Neighborhood Hits	1762	Target Neighborhood Hits	826	Shared Neighborhood Hits	812
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

M4K5_HUMAN
NC score	0.825711 (rank : 355)	θ value	1.29331e-14 (rank : 401)
Query Neighborhood Hits	1762	Target Neighborhood Hits	845	Shared Neighborhood Hits	814
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

PCTK1_HUMAN
NC score	0.825625 (rank : 356)	θ value	1.29331e-14 (rank : 403)
Query Neighborhood Hits	1762	Target Neighborhood Hits	832	Shared Neighborhood Hits	812
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

PCTK1_MOUSE
NC score	0.825423 (rank : 357)	θ value	1.29331e-14 (rank : 404)
Query Neighborhood Hits	1762	Target Neighborhood Hits	832	Shared Neighborhood Hits	811
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

CDK6_MOUSE
NC score	0.825359 (rank : 358)	θ value	1.86753e-13 (rank : 453)
Query Neighborhood Hits	1762	Target Neighborhood Hits	837	Shared Neighborhood Hits	820
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

TLK2_MOUSE
NC score	0.825192 (rank : 359)	θ value	6.00763e-12 (rank : 514)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1088	Shared Neighborhood Hits	791
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

MP2K7_HUMAN
NC score	0.825164 (rank : 360)	θ value	3.64472e-09 (rank : 618)
Query Neighborhood Hits	1762	Target Neighborhood Hits	833	Shared Neighborhood Hits	808
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

DMPK_MOUSE
NC score	0.824920 (rank : 361)	θ value	1.80466e-16 (rank : 299)
Query Neighborhood Hits	1762	Target Neighborhood Hits	908	Shared Neighborhood Hits	814
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

CDK6_HUMAN
NC score	0.824878 (rank : 362)	θ value	2.43908e-13 (rank : 456)
Query Neighborhood Hits	1762	Target Neighborhood Hits	837	Shared Neighborhood Hits	820
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

MK15_HUMAN
NC score	0.824707 (rank : 363)	θ value	8.67504e-11 (rank : 555)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1038	Shared Neighborhood Hits	884
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

PCTK3_HUMAN
NC score	0.824602 (rank : 364)	θ value	1.52774e-15 (rank : 356)
Query Neighborhood Hits	1762	Target Neighborhood Hits	827	Shared Neighborhood Hits	806
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

CD2L7_HUMAN
NC score	0.824536 (rank : 365)	θ value	1.38178e-16 (rank : 291)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1275	Shared Neighborhood Hits	967
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

DMPK_HUMAN
NC score	0.824494 (rank : 366)	θ value	7.58209e-15 (rank : 384)
Query Neighborhood Hits	1762	Target Neighborhood Hits	944	Shared Neighborhood Hits	819
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

ST38L_MOUSE
NC score	0.824311 (rank : 367)	θ value	5.60996e-18 (rank : 227)
Query Neighborhood Hits	1762	Target Neighborhood Hits	821	Shared Neighborhood Hits	786
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

CCRK_HUMAN
NC score	0.824306 (rank : 368)	θ value	3.18553e-13 (rank : 464)
Query Neighborhood Hits	1762	Target Neighborhood Hits	835	Shared Neighborhood Hits	819
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

CCRK_MOUSE
NC score	0.823770 (rank : 369)	θ value	5.43371e-13 (rank : 475)
Query Neighborhood Hits	1762	Target Neighborhood Hits	832	Shared Neighborhood Hits	817
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

GSK3A_HUMAN
NC score	0.823601 (rank : 370)	θ value	1.09485e-13 (rank : 445)
Query Neighborhood Hits	1762	Target Neighborhood Hits	835	Shared Neighborhood Hits	795
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

PCTK2_HUMAN
NC score	0.823241 (rank : 371)	θ value	1.52774e-15 (rank : 354)
Query Neighborhood Hits	1762	Target Neighborhood Hits	837	Shared Neighborhood Hits	812
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

MK15_MOUSE
NC score	0.823122 (rank : 372)	θ value	6.21693e-09 (rank : 629)
Query Neighborhood Hits	1762	Target Neighborhood Hits	843	Shared Neighborhood Hits	822
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

F5006_MOUSE
NC score	0.822903 (rank : 373)	θ value	8.11959e-09 (rank : 635)
Query Neighborhood Hits	1762	Target Neighborhood Hits	793	Shared Neighborhood Hits	785
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

PCTK2_MOUSE
NC score	0.822880 (rank : 374)	θ value	1.52774e-15 (rank : 355)
Query Neighborhood Hits	1762	Target Neighborhood Hits	836	Shared Neighborhood Hits	813
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

MK12_MOUSE
NC score	0.822868 (rank : 375)	θ value	9.90251e-15 (rank : 392)
Query Neighborhood Hits	1762	Target Neighborhood Hits	835	Shared Neighborhood Hits	814
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

GSK3B_MOUSE
NC score	0.821730 (rank : 376)	θ value	4.16044e-13 (rank : 473)
Query Neighborhood Hits	1762	Target Neighborhood Hits	800	Shared Neighborhood Hits	791
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_HUMAN
NC score	0.821727 (rank : 377)	θ value	4.16044e-13 (rank : 472)
Query Neighborhood Hits	1762	Target Neighborhood Hits	801	Shared Neighborhood Hits	791
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

MK12_HUMAN
NC score	0.821496 (rank : 378)	θ value	3.18553e-13 (rank : 466)
Query Neighborhood Hits	1762	Target Neighborhood Hits	830	Shared Neighborhood Hits	813
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

STK16_HUMAN
NC score	0.820643 (rank : 379)	θ value	6.21693e-09 (rank : 632)
Query Neighborhood Hits	1762	Target Neighborhood Hits	824	Shared Neighborhood Hits	810
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

AL2S7_HUMAN
NC score	0.820467 (rank : 380)	θ value	5.8054e-15 (rank : 381)
Query Neighborhood Hits	1762	Target Neighborhood Hits	831	Shared Neighborhood Hits	811
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

NRK_HUMAN
NC score	0.820441 (rank : 381)	θ value	3.18553e-13 (rank : 467)
Query Neighborhood Hits	1762	Target Neighborhood Hits	931	Shared Neighborhood Hits	835
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

MK07_MOUSE
NC score	0.819991 (rank : 382)	θ value	1.52774e-15 (rank : 352)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1054	Shared Neighborhood Hits	926
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

MK07_HUMAN
NC score	0.819701 (rank : 383)	θ value	3.40345e-15 (rank : 369)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1087	Shared Neighborhood Hits	946
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

CD2L5_MOUSE
NC score	0.819626 (rank : 384)	θ value	1.16975e-15 (rank : 345)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1011	Shared Neighborhood Hits	871
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

MK14_MOUSE
NC score	0.819427 (rank : 385)	θ value	6.00763e-12 (rank : 511)
Query Neighborhood Hits	1762	Target Neighborhood Hits	838	Shared Neighborhood Hits	817
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

CD2L5_HUMAN
NC score	0.819343 (rank : 386)	θ value	1.16975e-15 (rank : 344)
Query Neighborhood Hits	1762	Target Neighborhood Hits	987	Shared Neighborhood Hits	857
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

NRK_MOUSE
NC score	0.819309 (rank : 387)	θ value	5.43371e-13 (rank : 478)
Query Neighborhood Hits	1762	Target Neighborhood Hits	899	Shared Neighborhood Hits	833
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

STK16_MOUSE
NC score	0.819302 (rank : 388)	θ value	6.21693e-09 (rank : 633)
Query Neighborhood Hits	1762	Target Neighborhood Hits	824	Shared Neighborhood Hits	804
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

MK14_HUMAN
NC score	0.819238 (rank : 389)	θ value	2.0648e-12 (rank : 499)
Query Neighborhood Hits	1762	Target Neighborhood Hits	838	Shared Neighborhood Hits	817
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

F5006_HUMAN
NC score	0.819119 (rank : 390)	θ value	5.26297e-08 (rank : 672)
Query Neighborhood Hits	1762	Target Neighborhood Hits	794	Shared Neighborhood Hits	783
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

KPCA_MOUSE
NC score	0.818968 (rank : 391)	θ value	4.74913e-17 (rank : 272)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1067	Shared Neighborhood Hits	820
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

MK13_MOUSE
NC score	0.818688 (rank : 392)	θ value	7.09661e-13 (rank : 481)
Query Neighborhood Hits	1762	Target Neighborhood Hits	832	Shared Neighborhood Hits	814
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

KPCA_HUMAN
NC score	0.818349 (rank : 393)	θ value	8.65492e-19 (rank : 196)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1070	Shared Neighborhood Hits	823
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

MP2K4_HUMAN
NC score	0.818186 (rank : 394)	θ value	1.53129e-07 (rank : 702)
Query Neighborhood Hits	1762	Target Neighborhood Hits	832	Shared Neighborhood Hits	812
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K4_MOUSE
NC score	0.818161 (rank : 395)	θ value	1.53129e-07 (rank : 703)
Query Neighborhood Hits	1762	Target Neighborhood Hits	833	Shared Neighborhood Hits	812
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

MOK_HUMAN
NC score	0.817797 (rank : 396)	θ value	1.86753e-13 (rank : 454)
Query Neighborhood Hits	1762	Target Neighborhood Hits	807	Shared Neighborhood Hits	794
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

MK04_HUMAN
NC score	0.817414 (rank : 397)	θ value	6.00763e-12 (rank : 510)
Query Neighborhood Hits	1762	Target Neighborhood Hits	837	Shared Neighborhood Hits	816
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

MK13_HUMAN
NC score	0.816986 (rank : 398)	θ value	3.89403e-11 (rank : 543)
Query Neighborhood Hits	1762	Target Neighborhood Hits	829	Shared Neighborhood Hits	814
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

NLK_MOUSE
NC score	0.816922 (rank : 399)	θ value	3.40345e-15 (rank : 371)
Query Neighborhood Hits	1762	Target Neighborhood Hits	839	Shared Neighborhood Hits	821
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

ERN1_HUMAN
NC score	0.816855 (rank : 400)	θ value	1.9326e-10 (rank : 568)
Query Neighborhood Hits	1762	Target Neighborhood Hits	829	Shared Neighborhood Hits	807
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

NLK_HUMAN
NC score	0.816852 (rank : 401)	θ value	3.40345e-15 (rank : 370)
Query Neighborhood Hits	1762	Target Neighborhood Hits	840	Shared Neighborhood Hits	821
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

MK04_MOUSE
NC score	0.816724 (rank : 402)	θ value	1.42992e-13 (rank : 449)
Query Neighborhood Hits	1762	Target Neighborhood Hits	852	Shared Neighborhood Hits	812
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

MP2K3_MOUSE
NC score	0.815949 (rank : 403)	θ value	1.06045e-08 (rank : 645)
Query Neighborhood Hits	1762	Target Neighborhood Hits	826	Shared Neighborhood Hits	811
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

ERN1_MOUSE
NC score	0.815886 (rank : 404)	θ value	3.29651e-10 (rank : 573)
Query Neighborhood Hits	1762	Target Neighborhood Hits	823	Shared Neighborhood Hits	807
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

MOK_MOUSE
NC score	0.815575 (rank : 405)	θ value	1.42992e-13 (rank : 450)
Query Neighborhood Hits	1762	Target Neighborhood Hits	796	Shared Neighborhood Hits	788
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

TAOK2_HUMAN
NC score	0.815496 (rank : 406)	θ value	3.40345e-15 (rank : 373)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1172	Shared Neighborhood Hits	857
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

CDK4_MOUSE
NC score	0.815425 (rank : 407)	θ value	3.89403e-11 (rank : 541)
Query Neighborhood Hits	1762	Target Neighborhood Hits	838	Shared Neighborhood Hits	819
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

CDK4_HUMAN
NC score	0.815299 (rank : 408)	θ value	2.98157e-11 (rank : 537)
Query Neighborhood Hits	1762	Target Neighborhood Hits	834	Shared Neighborhood Hits	819
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

MKNK1_HUMAN
NC score	0.815103 (rank : 409)	θ value	3.76295e-14 (rank : 430)
Query Neighborhood Hits	1762	Target Neighborhood Hits	701	Shared Neighborhood Hits	686
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

MP2K3_HUMAN
NC score	0.814814 (rank : 410)	θ value	1.06045e-08 (rank : 644)
Query Neighborhood Hits	1762	Target Neighborhood Hits	825	Shared Neighborhood Hits	811
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MK11_MOUSE
NC score	0.814500 (rank : 411)	θ value	1.47974e-10 (rank : 563)
Query Neighborhood Hits	1762	Target Neighborhood Hits	835	Shared Neighborhood Hits	818
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

MK03_MOUSE
NC score	0.814283 (rank : 412)	θ value	4.44505e-15 (rank : 378)
Query Neighborhood Hits	1762	Target Neighborhood Hits	840	Shared Neighborhood Hits	817
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

ERN2_HUMAN
NC score	0.814228 (rank : 413)	θ value	1.02475e-11 (rank : 523)
Query Neighborhood Hits	1762	Target Neighborhood Hits	844	Shared Neighborhood Hits	815
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

MK03_HUMAN
NC score	0.814157 (rank : 414)	θ value	1.68911e-14 (rank : 414)
Query Neighborhood Hits	1762	Target Neighborhood Hits	837	Shared Neighborhood Hits	817
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

CDK10_HUMAN
NC score	0.813786 (rank : 415)	θ value	4.16044e-13 (rank : 471)
Query Neighborhood Hits	1762	Target Neighborhood Hits	831	Shared Neighborhood Hits	818
SwissProt Accessions	Q15131, Q15130	Gene names	CDK10
Domain Architecture
Description	Cell division protein kinase 10 (EC 2.7.11.22) (Serine/threonine- protein kinase PISSLRE).

CSK21_MOUSE
NC score	0.813568 (rank : 416)	θ value	9.59137e-10 (rank : 590)
Query Neighborhood Hits	1762	Target Neighborhood Hits	770	Shared Neighborhood Hits	763
SwissProt Accessions	Q60737	Gene names	Csnk2a1, Ckiia
Domain Architecture
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

E2AK1_MOUSE
NC score	0.813547 (rank : 417)	θ value	9.92553e-07 (rank : 741)
Query Neighborhood Hits	1762	Target Neighborhood Hits	821	Shared Neighborhood Hits	803
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

CSK21_HUMAN
NC score	0.813320 (rank : 418)	θ value	9.59137e-10 (rank : 589)
Query Neighborhood Hits	1762	Target Neighborhood Hits	772	Shared Neighborhood Hits	764
SwissProt Accessions	P68400, P19138, P20426, Q14013	Gene names	CSNK2A1, CK2A1
Domain Architecture	No domain graphic available
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

STK40_HUMAN
NC score	0.813215 (rank : 419)	θ value	3.08544e-08 (rank : 664)
Query Neighborhood Hits	1762	Target Neighborhood Hits	751	Shared Neighborhood Hits	738
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

STK40_MOUSE
NC score	0.813052 (rank : 420)	θ value	3.08544e-08 (rank : 665)
Query Neighborhood Hits	1762	Target Neighborhood Hits	751	Shared Neighborhood Hits	738
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

CDK9_HUMAN
NC score	0.813027 (rank : 421)	θ value	1.16975e-15 (rank : 346)
Query Neighborhood Hits	1762	Target Neighborhood Hits	822	Shared Neighborhood Hits	806
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

MP2K6_MOUSE
NC score	0.812688 (rank : 422)	θ value	4.30538e-10 (rank : 579)
Query Neighborhood Hits	1762	Target Neighborhood Hits	830	Shared Neighborhood Hits	811
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

KPCB_MOUSE
NC score	0.812515 (rank : 423)	θ value	7.32683e-18 (rank : 231)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1117	Shared Neighborhood Hits	821
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

MK09_HUMAN
NC score	0.812505 (rank : 424)	θ value	8.11959e-09 (rank : 638)
Query Neighborhood Hits	1762	Target Neighborhood Hits	842	Shared Neighborhood Hits	820
SwissProt Accessions	P45984, Q15708, Q15710, Q15711, Q8N5C5	Gene names	MAPK9, JNK2, PRKM9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).

CDK9_MOUSE
NC score	0.812421 (rank : 425)	θ value	2.60593e-15 (rank : 360)
Query Neighborhood Hits	1762	Target Neighborhood Hits	822	Shared Neighborhood Hits	806
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

SLK_MOUSE
NC score	0.812383 (rank : 426)	θ value	3.40345e-15 (rank : 372)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1798	Shared Neighborhood Hits	896
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

KPCG_MOUSE
NC score	0.812334 (rank : 427)	θ value	2.27762e-19 (rank : 183)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1123	Shared Neighborhood Hits	821
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

MINK1_HUMAN
NC score	0.812221 (rank : 428)	θ value	1.52774e-15 (rank : 350)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1477	Shared Neighborhood Hits	919
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MK01_HUMAN
NC score	0.812179 (rank : 429)	θ value	2.60593e-15 (rank : 361)
Query Neighborhood Hits	1762	Target Neighborhood Hits	836	Shared Neighborhood Hits	816
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

KPCB_HUMAN
NC score	0.812101 (rank : 430)	θ value	7.32683e-18 (rank : 230)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1121	Shared Neighborhood Hits	822
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCG_HUMAN
NC score	0.812083 (rank : 431)	θ value	2.27762e-19 (rank : 182)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1126	Shared Neighborhood Hits	821
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

MINK1_MOUSE
NC score	0.812022 (rank : 432)	θ value	1.52774e-15 (rank : 351)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1451	Shared Neighborhood Hits	901
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

ERN2_MOUSE
NC score	0.811991 (rank : 433)	θ value	2.98157e-11 (rank : 538)
Query Neighborhood Hits	1762	Target Neighborhood Hits	825	Shared Neighborhood Hits	804
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

MK01_MOUSE
NC score	0.811971 (rank : 434)	θ value	3.40345e-15 (rank : 368)
Query Neighborhood Hits	1762	Target Neighborhood Hits	836	Shared Neighborhood Hits	816
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MP2K6_HUMAN
NC score	0.811796 (rank : 435)	θ value	5.08577e-11 (rank : 544)
Query Neighborhood Hits	1762	Target Neighborhood Hits	830	Shared Neighborhood Hits	810
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

TNIK_HUMAN
NC score	0.810994 (rank : 436)	θ value	7.58209e-15 (rank : 388)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1570	Shared Neighborhood Hits	909
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

LATS1_HUMAN
NC score	0.810659 (rank : 437)	θ value	3.18553e-13 (rank : 465)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1057	Shared Neighborhood Hits	880
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

SLK_HUMAN
NC score	0.810546 (rank : 438)	θ value	2.20605e-14 (rank : 426)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1775	Shared Neighborhood Hits	891
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

E2AK3_HUMAN
NC score	0.810457 (rank : 439)	θ value	1.29631e-06 (rank : 747)
Query Neighborhood Hits	1762	Target Neighborhood Hits	859	Shared Neighborhood Hits	818
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

MK09_MOUSE
NC score	0.808840 (rank : 440)	θ value	1.06045e-08 (rank : 641)
Query Neighborhood Hits	1762	Target Neighborhood Hits	843	Shared Neighborhood Hits	819
SwissProt Accessions	Q9WTU6, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5	Gene names	Mapk9, Jnk2, Prkm9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2).

E2AK3_MOUSE
NC score	0.808737 (rank : 441)	θ value	5.81887e-07 (rank : 726)
Query Neighborhood Hits	1762	Target Neighborhood Hits	851	Shared Neighborhood Hits	825
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

E2AK1_HUMAN
NC score	0.808690 (rank : 442)	θ value	4.92598e-06 (rank : 761)
Query Neighborhood Hits	1762	Target Neighborhood Hits	833	Shared Neighborhood Hits	806
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

MK11_HUMAN
NC score	0.808206 (rank : 443)	θ value	5.62301e-10 (rank : 584)
Query Neighborhood Hits	1762	Target Neighborhood Hits	823	Shared Neighborhood Hits	813
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

CSK22_HUMAN
NC score	0.807942 (rank : 444)	θ value	1.63604e-09 (rank : 597)
Query Neighborhood Hits	1762	Target Neighborhood Hits	758	Shared Neighborhood Hits	754
SwissProt Accessions	P19784	Gene names	CSNK2A2, CK2A2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

CSK22_MOUSE
NC score	0.807909 (rank : 445)	θ value	3.64472e-09 (rank : 613)
Query Neighborhood Hits	1762	Target Neighborhood Hits	758	Shared Neighborhood Hits	754
SwissProt Accessions	O54833	Gene names	Csnk2a2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

LATS1_MOUSE
NC score	0.807801 (rank : 446)	θ value	6.64225e-11 (rank : 548)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1027	Shared Neighborhood Hits	869
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

MK08_MOUSE
NC score	0.806886 (rank : 447)	θ value	8.97725e-08 (rank : 689)
Query Neighborhood Hits	1762	Target Neighborhood Hits	834	Shared Neighborhood Hits	815
SwissProt Accessions	Q91Y86	Gene names	Mapk8, Jnk1, Prkm8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1).

MK06_HUMAN
NC score	0.806884 (rank : 448)	θ value	1.02475e-11 (rank : 524)
Query Neighborhood Hits	1762	Target Neighborhood Hits	815	Shared Neighborhood Hits	791
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

MK06_MOUSE
NC score	0.806639 (rank : 449)	θ value	1.02475e-11 (rank : 525)
Query Neighborhood Hits	1762	Target Neighborhood Hits	818	Shared Neighborhood Hits	791
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

WNK3_HUMAN
NC score	0.806602 (rank : 450)	θ value	7.09661e-13 (rank : 485)
Query Neighborhood Hits	1762	Target Neighborhood Hits	948	Shared Neighborhood Hits	779
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

HIPK4_HUMAN
NC score	0.806572 (rank : 451)	θ value	3.89403e-11 (rank : 542)
Query Neighborhood Hits	1762	Target Neighborhood Hits	799	Shared Neighborhood Hits	783
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

MK08_HUMAN
NC score	0.806232 (rank : 452)	θ value	8.97725e-08 (rank : 688)
Query Neighborhood Hits	1762	Target Neighborhood Hits	834	Shared Neighborhood Hits	815
SwissProt Accessions	P45983, Q15709, Q15712, Q15713	Gene names	MAPK8, JNK1, PRKM8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46).

MK10_HUMAN
NC score	0.805958 (rank : 453)	θ value	1.06045e-08 (rank : 642)
Query Neighborhood Hits	1762	Target Neighborhood Hits	836	Shared Neighborhood Hits	816
SwissProt Accessions	P53779, Q15707	Gene names	MAPK10, JNK3, JNK3A, PRKM10
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

LATS2_MOUSE
NC score	0.805560 (rank : 454)	θ value	2.28291e-11 (rank : 536)
Query Neighborhood Hits	1762	Target Neighborhood Hits	879	Shared Neighborhood Hits	822
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

MK10_MOUSE
NC score	0.805459 (rank : 455)	θ value	1.06045e-08 (rank : 643)
Query Neighborhood Hits	1762	Target Neighborhood Hits	849	Shared Neighborhood Hits	819
SwissProt Accessions	Q61831, Q9R0U6	Gene names	Mapk10, Jnk3, Prkm10, Serk2
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

LATS2_HUMAN
NC score	0.804606 (rank : 456)	θ value	6.21693e-09 (rank : 627)
Query Neighborhood Hits	1762	Target Neighborhood Hits	884	Shared Neighborhood Hits	828
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

TAOK2_MOUSE
NC score	0.802799 (rank : 457)	θ value	1.16975e-15 (rank : 348)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1373	Shared Neighborhood Hits	866
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

M3K13_HUMAN
NC score	0.802257 (rank : 458)	θ value	8.10077e-17 (rank : 281)
Query Neighborhood Hits	1762	Target Neighborhood Hits	911	Shared Neighborhood Hits	828
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

WNK4_MOUSE
NC score	0.802254 (rank : 459)	θ value	4.59992e-12 (rank : 509)
Query Neighborhood Hits	1762	Target Neighborhood Hits	961	Shared Neighborhood Hits	823
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

WNK1_HUMAN
NC score	0.801871 (rank : 460)	θ value	2.43908e-13 (rank : 462)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1158	Shared Neighborhood Hits	877
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

DYRK3_HUMAN
NC score	0.801728 (rank : 461)	θ value	1.58096e-12 (rank : 497)
Query Neighborhood Hits	1762	Target Neighborhood Hits	798	Shared Neighborhood Hits	781
SwissProt Accessions	O43781	Gene names	DYRK3
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1).

WNK4_HUMAN
NC score	0.801068 (rank : 462)	θ value	1.58096e-12 (rank : 498)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1043	Shared Neighborhood Hits	862
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

CI096_HUMAN
NC score	0.801017 (rank : 463)	θ value	8.40245e-06 (rank : 775)
Query Neighborhood Hits	1762	Target Neighborhood Hits	821	Shared Neighborhood Hits	796
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

DYRK2_HUMAN
NC score	0.800795 (rank : 464)	θ value	8.67504e-11 (rank : 553)
Query Neighborhood Hits	1762	Target Neighborhood Hits	799	Shared Neighborhood Hits	782
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

DAPK1_HUMAN
NC score	0.800276 (rank : 465)	θ value	3.2585e-50 (rank : 10)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1130	Shared Neighborhood Hits	839
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

CD2L6_MOUSE
NC score	0.799891 (rank : 466)	θ value	3.64472e-09 (rank : 612)
Query Neighborhood Hits	1762	Target Neighborhood Hits	851	Shared Neighborhood Hits	819
SwissProt Accessions	Q8BWD8, Q80TM1	Gene names	Cdc2l6, Kiaa1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6).

CD2L6_HUMAN
NC score	0.799697 (rank : 467)	θ value	3.64472e-09 (rank : 611)
Query Neighborhood Hits	1762	Target Neighborhood Hits	844	Shared Neighborhood Hits	815
SwissProt Accessions	Q9BWU1, Q5JQZ7, Q5JR00, Q8TC78, Q9UPX2	Gene names	CDC2L6, CDK11, KIAA1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11).

WNK1_MOUSE
NC score	0.799244 (rank : 468)	θ value	2.43908e-13 (rank : 463)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1179	Shared Neighborhood Hits	862
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

M4K4_HUMAN
NC score	0.799130 (rank : 469)	θ value	3.40345e-15 (rank : 367)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1589	Shared Neighborhood Hits	882
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

CD2L2_HUMAN
NC score	0.798883 (rank : 470)	θ value	8.67504e-11 (rank : 552)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1439	Shared Neighborhood Hits	877
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

WNK2_HUMAN
NC score	0.798786 (rank : 471)	θ value	1.33837e-11 (rank : 532)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1407	Shared Neighborhood Hits	979
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

RIPK5_HUMAN
NC score	0.798291 (rank : 472)	θ value	8.67504e-11 (rank : 556)
Query Neighborhood Hits	1762	Target Neighborhood Hits	864	Shared Neighborhood Hits	818
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK5_MOUSE
NC score	0.797564 (rank : 473)	θ value	8.67504e-11 (rank : 557)
Query Neighborhood Hits	1762	Target Neighborhood Hits	874	Shared Neighborhood Hits	819
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

CD2L1_HUMAN
NC score	0.796611 (rank : 474)	θ value	1.02475e-11 (rank : 521)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1467	Shared Neighborhood Hits	872
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

CD2L1_MOUSE
NC score	0.796526 (rank : 475)	θ value	1.02475e-11 (rank : 522)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1463	Shared Neighborhood Hits	870
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

CDK8_HUMAN
NC score	0.796449 (rank : 476)	θ value	1.17247e-07 (rank : 692)
Query Neighborhood Hits	1762	Target Neighborhood Hits	831	Shared Neighborhood Hits	809
SwissProt Accessions	P49336	Gene names	CDK8
Domain Architecture
Description	Cell division protein kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Protein kinase K35).

DAPK1_MOUSE
NC score	0.796112 (rank : 477)	θ value	5.55816e-50 (rank : 11)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1138	Shared Neighborhood Hits	840
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

M3K12_HUMAN
NC score	0.794955 (rank : 478)	θ value	1.058e-16 (rank : 286)
Query Neighborhood Hits	1762	Target Neighborhood Hits	940	Shared Neighborhood Hits	851
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
NC score	0.794796 (rank : 479)	θ value	1.058e-16 (rank : 287)
Query Neighborhood Hits	1762	Target Neighborhood Hits	957	Shared Neighborhood Hits	854
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

DYR1B_MOUSE
NC score	0.794786 (rank : 480)	θ value	1.25267e-09 (rank : 592)
Query Neighborhood Hits	1762	Target Neighborhood Hits	799	Shared Neighborhood Hits	777
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

E2AK4_HUMAN
NC score	0.794168 (rank : 481)	θ value	0.000786445 (rank : 899)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1012	Shared Neighborhood Hits	836
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

STK10_HUMAN
NC score	0.793989 (rank : 482)	θ value	2.7842e-17 (rank : 260)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1921	Shared Neighborhood Hits	929
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

M4K4_MOUSE
NC score	0.793984 (rank : 483)	θ value	2.43908e-13 (rank : 459)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1560	Shared Neighborhood Hits	884
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

GAK_HUMAN
NC score	0.793644 (rank : 484)	θ value	7.34386e-10 (rank : 587)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1028	Shared Neighborhood Hits	863
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

TAOK3_MOUSE
NC score	0.793110 (rank : 485)	θ value	2.20605e-14 (rank : 428)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1458	Shared Neighborhood Hits	857
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

WEE1_MOUSE
NC score	0.792844 (rank : 486)	θ value	7.59969e-07 (rank : 740)
Query Neighborhood Hits	1762	Target Neighborhood Hits	794	Shared Neighborhood Hits	759
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

BMP2K_MOUSE
NC score	0.791788 (rank : 487)	θ value	1.87187e-05 (rank : 797)
Query Neighborhood Hits	1762	Target Neighborhood Hits	874	Shared Neighborhood Hits	786
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

MRCKG_HUMAN
NC score	0.791459 (rank : 488)	θ value	2.35696e-16 (rank : 315)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1519	Shared Neighborhood Hits	858
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

DYR1B_HUMAN
NC score	0.790891 (rank : 489)	θ value	1.63604e-09 (rank : 598)
Query Neighborhood Hits	1762	Target Neighborhood Hits	831	Shared Neighborhood Hits	785
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

E2AK4_MOUSE
NC score	0.790580 (rank : 490)	θ value	0.00102713 (rank : 907)
Query Neighborhood Hits	1762	Target Neighborhood Hits	984	Shared Neighborhood Hits	834
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

AAK1_HUMAN
NC score	0.790563 (rank : 491)	θ value	1.43324e-05 (rank : 787)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1077	Shared Neighborhood Hits	909
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

TAOK3_HUMAN
NC score	0.790464 (rank : 492)	θ value	6.41864e-14 (rank : 438)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1494	Shared Neighborhood Hits	862
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

MRCKG_MOUSE
NC score	0.790395 (rank : 493)	θ value	6.85773e-16 (rank : 337)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1466	Shared Neighborhood Hits	849
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

GAK_MOUSE
NC score	0.790310 (rank : 494)	θ value	1.63604e-09 (rank : 599)
Query Neighborhood Hits	1762	Target Neighborhood Hits	964	Shared Neighborhood Hits	830
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

BMP2K_HUMAN
NC score	0.790201 (rank : 495)	θ value	1.87187e-05 (rank : 796)
Query Neighborhood Hits	1762	Target Neighborhood Hits	867	Shared Neighborhood Hits	788
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

TESK1_MOUSE
NC score	0.790092 (rank : 496)	θ value	2.52405e-10 (rank : 571)
Query Neighborhood Hits	1762	Target Neighborhood Hits	862	Shared Neighborhood Hits	812
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK2_MOUSE
NC score	0.789257 (rank : 497)	θ value	3.52202e-12 (rank : 506)
Query Neighborhood Hits	1762	Target Neighborhood Hits	833	Shared Neighborhood Hits	801
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TESK2_HUMAN
NC score	0.789166 (rank : 498)	θ value	3.18553e-13 (rank : 469)
Query Neighborhood Hits	1762	Target Neighborhood Hits	851	Shared Neighborhood Hits	808
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

AAK1_MOUSE
NC score	0.788835 (rank : 499)	θ value	1.43324e-05 (rank : 788)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1051	Shared Neighborhood Hits	885
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

TESK1_HUMAN
NC score	0.788353 (rank : 500)	θ value	4.76016e-09 (rank : 624)
Query Neighborhood Hits	1762	Target Neighborhood Hits	864	Shared Neighborhood Hits	814
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

M3K7_MOUSE
NC score	0.787263 (rank : 501)	θ value	2.43908e-13 (rank : 458)
Query Neighborhood Hits	1762	Target Neighborhood Hits	892	Shared Neighborhood Hits	816
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_HUMAN
NC score	0.787167 (rank : 502)	θ value	2.43908e-13 (rank : 457)
Query Neighborhood Hits	1762	Target Neighborhood Hits	892	Shared Neighborhood Hits	816
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

DYRK4_HUMAN
NC score	0.786715 (rank : 503)	θ value	1.9326e-10 (rank : 567)
Query Neighborhood Hits	1762	Target Neighborhood Hits	750	Shared Neighborhood Hits	742
SwissProt Accessions	Q9NR20, Q8NEF2, Q92631	Gene names	DYRK4
Domain Architecture	No domain graphic available
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1).

HIPK3_MOUSE
NC score	0.785768 (rank : 504)	θ value	1.25267e-09 (rank : 594)
Query Neighborhood Hits	1762	Target Neighborhood Hits	857	Shared Neighborhood Hits	802
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

UHMK1_HUMAN
NC score	0.785751 (rank : 505)	θ value	0.000158464 (rank : 862)
Query Neighborhood Hits	1762	Target Neighborhood Hits	808	Shared Neighborhood Hits	764
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

IRAK4_MOUSE
NC score	0.785045 (rank : 506)	θ value	2.79066e-09 (rank : 609)
Query Neighborhood Hits	1762	Target Neighborhood Hits	820	Shared Neighborhood Hits	794
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

UHMK1_MOUSE
NC score	0.784619 (rank : 507)	θ value	0.000158464 (rank : 863)
Query Neighborhood Hits	1762	Target Neighborhood Hits	809	Shared Neighborhood Hits	764
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

RIPK1_HUMAN
NC score	0.784036 (rank : 508)	θ value	6.64225e-11 (rank : 550)
Query Neighborhood Hits	1762	Target Neighborhood Hits	891	Shared Neighborhood Hits	829
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

HIPK3_HUMAN
NC score	0.783828 (rank : 509)	θ value	1.25267e-09 (rank : 593)
Query Neighborhood Hits	1762	Target Neighborhood Hits	867	Shared Neighborhood Hits	803
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

HIPK1_HUMAN
NC score	0.783827 (rank : 510)	θ value	5.62301e-10 (rank : 581)
Query Neighborhood Hits	1762	Target Neighborhood Hits	843	Shared Neighborhood Hits	797
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

HIPK1_MOUSE
NC score	0.783492 (rank : 511)	θ value	5.62301e-10 (rank : 582)
Query Neighborhood Hits	1762	Target Neighborhood Hits	838	Shared Neighborhood Hits	793
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

WEE1_HUMAN
NC score	0.783270 (rank : 512)	θ value	5.26297e-08 (rank : 677)
Query Neighborhood Hits	1762	Target Neighborhood Hits	777	Shared Neighborhood Hits	744
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

HIPK2_HUMAN
NC score	0.783120 (rank : 513)	θ value	4.30538e-10 (rank : 577)
Query Neighborhood Hits	1762	Target Neighborhood Hits	845	Shared Neighborhood Hits	794
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

HIPK2_MOUSE
NC score	0.782416 (rank : 514)	θ value	4.30538e-10 (rank : 578)
Query Neighborhood Hits	1762	Target Neighborhood Hits	871	Shared Neighborhood Hits	800
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

TAOK1_MOUSE
NC score	0.780999 (rank : 515)	θ value	2.60593e-15 (rank : 364)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1720	Shared Neighborhood Hits	889
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

DYR1A_MOUSE
NC score	0.780761 (rank : 516)	θ value	2.79066e-09 (rank : 608)
Query Neighborhood Hits	1762	Target Neighborhood Hits	762	Shared Neighborhood Hits	747
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

DYR1A_HUMAN
NC score	0.780725 (rank : 517)	θ value	2.79066e-09 (rank : 607)
Query Neighborhood Hits	1762	Target Neighborhood Hits	764	Shared Neighborhood Hits	747
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

TAOK1_HUMAN
NC score	0.780632 (rank : 518)	θ value	2.60593e-15 (rank : 363)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1734	Shared Neighborhood Hits	892
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

IRAK4_HUMAN
NC score	0.779179 (rank : 519)	θ value	2.61198e-07 (rank : 714)
Query Neighborhood Hits	1762	Target Neighborhood Hits	816	Shared Neighborhood Hits	795
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

RIPK1_MOUSE
NC score	0.777004 (rank : 520)	θ value	1.9326e-10 (rank : 569)
Query Neighborhood Hits	1762	Target Neighborhood Hits	874	Shared Neighborhood Hits	821
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RAF1_MOUSE
NC score	0.775504 (rank : 521)	θ value	9.26847e-13 (rank : 489)
Query Neighborhood Hits	1762	Target Neighborhood Hits	886	Shared Neighborhood Hits	825
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAF1_HUMAN
NC score	0.775173 (rank : 522)	θ value	9.26847e-13 (rank : 488)
Query Neighborhood Hits	1762	Target Neighborhood Hits	886	Shared Neighborhood Hits	824
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

PRP4B_HUMAN
NC score	0.774517 (rank : 523)	θ value	3.29651e-10 (rank : 575)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1030	Shared Neighborhood Hits	805
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

BRAF1_HUMAN
NC score	0.774094 (rank : 524)	θ value	3.29651e-10 (rank : 572)
Query Neighborhood Hits	1762	Target Neighborhood Hits	883	Shared Neighborhood Hits	816
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

M3K11_HUMAN
NC score	0.773236 (rank : 525)	θ value	7.84624e-12 (rank : 517)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1136	Shared Neighborhood Hits	892
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

MOS_MOUSE
NC score	0.772902 (rank : 526)	θ value	1.02475e-11 (rank : 526)
Query Neighborhood Hits	1762	Target Neighborhood Hits	833	Shared Neighborhood Hits	811
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

PRP4B_MOUSE
NC score	0.772698 (rank : 527)	θ value	3.29651e-10 (rank : 576)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1040	Shared Neighborhood Hits	802
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

STK10_MOUSE
NC score	0.772694 (rank : 528)	θ value	8.10077e-17 (rank : 285)
Query Neighborhood Hits	1762	Target Neighborhood Hits	2132	Shared Neighborhood Hits	954
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

MOS_HUMAN
NC score	0.772117 (rank : 529)	θ value	3.64472e-09 (rank : 617)
Query Neighborhood Hits	1762	Target Neighborhood Hits	829	Shared Neighborhood Hits	811
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

M3K10_HUMAN
NC score	0.771901 (rank : 530)	θ value	8.38298e-14 (rank : 441)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1071	Shared Neighborhood Hits	838
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K9_HUMAN
NC score	0.771698 (rank : 531)	θ value	3.52202e-12 (rank : 503)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1123	Shared Neighborhood Hits	861
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

ARAF_HUMAN
NC score	0.770972 (rank : 532)	θ value	4.59992e-12 (rank : 507)
Query Neighborhood Hits	1762	Target Neighborhood Hits	924	Shared Neighborhood Hits	831
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ARAF_MOUSE
NC score	0.770913 (rank : 533)	θ value	7.09661e-13 (rank : 479)
Query Neighborhood Hits	1762	Target Neighborhood Hits	874	Shared Neighborhood Hits	819
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

TRIB2_HUMAN
NC score	0.770423 (rank : 534)	θ value	1.99992e-07 (rank : 708)
Query Neighborhood Hits	1762	Target Neighborhood Hits	657	Shared Neighborhood Hits	649
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB2_MOUSE
NC score	0.769807 (rank : 535)	θ value	4.45536e-07 (rank : 723)
Query Neighborhood Hits	1762	Target Neighborhood Hits	653	Shared Neighborhood Hits	645
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

PTK7_HUMAN
NC score	0.769463 (rank : 536)	θ value	5.60996e-18 (rank : 226)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1103	Shared Neighborhood Hits	995
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

MLTK_MOUSE
NC score	0.769346 (rank : 537)	θ value	1.2105e-12 (rank : 494)
Query Neighborhood Hits	1762	Target Neighborhood Hits	874	Shared Neighborhood Hits	808
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

CLK1_MOUSE
NC score	0.769330 (rank : 538)	θ value	1.53129e-07 (rank : 699)
Query Neighborhood Hits	1762	Target Neighborhood Hits	760	Shared Neighborhood Hits	749
SwissProt Accessions	P22518	Gene names	Clk1, Clk, Sty
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY).

MLTK_HUMAN
NC score	0.769131 (rank : 539)	θ value	4.16044e-13 (rank : 474)
Query Neighborhood Hits	1762	Target Neighborhood Hits	911	Shared Neighborhood Hits	816
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

CLK1_HUMAN
NC score	0.769111 (rank : 540)	θ value	1.99992e-07 (rank : 706)
Query Neighborhood Hits	1762	Target Neighborhood Hits	756	Shared Neighborhood Hits	742
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

WEE1B_HUMAN
NC score	0.765946 (rank : 541)	θ value	1.53129e-07 (rank : 704)
Query Neighborhood Hits	1762	Target Neighborhood Hits	836	Shared Neighborhood Hits	747
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

CLK4_HUMAN
NC score	0.764548 (rank : 542)	θ value	8.97725e-08 (rank : 682)
Query Neighborhood Hits	1762	Target Neighborhood Hits	759	Shared Neighborhood Hits	751
SwissProt Accessions	Q9HAZ1	Gene names	CLK4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

CLK4_MOUSE
NC score	0.763430 (rank : 543)	θ value	5.26297e-08 (rank : 671)
Query Neighborhood Hits	1762	Target Neighborhood Hits	759	Shared Neighborhood Hits	749
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

WEE1B_MOUSE
NC score	0.763119 (rank : 544)	θ value	1.53129e-07 (rank : 705)
Query Neighborhood Hits	1762	Target Neighborhood Hits	765	Shared Neighborhood Hits	731
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

CLK2_HUMAN
NC score	0.760464 (rank : 545)	θ value	2.13673e-09 (rank : 601)
Query Neighborhood Hits	1762	Target Neighborhood Hits	752	Shared Neighborhood Hits	734
SwissProt Accessions	P49760, Q96CQ0	Gene names	CLK2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

M3KL4_HUMAN
NC score	0.760448 (rank : 546)	θ value	9.59137e-10 (rank : 591)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1087	Shared Neighborhood Hits	830
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

RIPK3_MOUSE
NC score	0.759296 (rank : 547)	θ value	2.44474e-05 (rank : 812)
Query Neighborhood Hits	1762	Target Neighborhood Hits	867	Shared Neighborhood Hits	809
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

FGFR1_MOUSE
NC score	0.757237 (rank : 548)	θ value	6.64225e-11 (rank : 547)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1068	Shared Neighborhood Hits	1009
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR1_HUMAN
NC score	0.757111 (rank : 549)	θ value	5.62301e-10 (rank : 580)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1069	Shared Neighborhood Hits	1012
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

LIMK2_HUMAN
NC score	0.756964 (rank : 550)	θ value	5.81887e-07 (rank : 729)
Query Neighborhood Hits	1762	Target Neighborhood Hits	986	Shared Neighborhood Hits	808
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

RIPK3_HUMAN
NC score	0.756556 (rank : 551)	θ value	5.81887e-07 (rank : 733)
Query Neighborhood Hits	1762	Target Neighborhood Hits	828	Shared Neighborhood Hits	796
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

LIMK1_HUMAN
NC score	0.754457 (rank : 552)	θ value	6.21693e-09 (rank : 628)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1005	Shared Neighborhood Hits	817
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK2_MOUSE
NC score	0.754120 (rank : 553)	θ value	4.45536e-07 (rank : 721)
Query Neighborhood Hits	1762	Target Neighborhood Hits	998	Shared Neighborhood Hits	807
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

FGFR2_HUMAN
NC score	0.753754 (rank : 554)	θ value	3.64472e-09 (rank : 615)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1062	Shared Neighborhood Hits	993
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

LIMK1_MOUSE
NC score	0.753471 (rank : 555)	θ value	1.80886e-08 (rank : 655)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1008	Shared Neighborhood Hits	815
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

KSR2_HUMAN
NC score	0.752949 (rank : 556)	θ value	7.1131e-05 (rank : 833)
Query Neighborhood Hits	1762	Target Neighborhood Hits	920	Shared Neighborhood Hits	840
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

FGFR2_MOUSE
NC score	0.750413 (rank : 557)	θ value	1.17247e-07 (rank : 693)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1062	Shared Neighborhood Hits	991
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

CLK2_MOUSE
NC score	0.748261 (rank : 558)	θ value	1.80886e-08 (rank : 654)
Query Neighborhood Hits	1762	Target Neighborhood Hits	743	Shared Neighborhood Hits	728
SwissProt Accessions	O35491	Gene names	Clk2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

FGFR3_MOUSE
NC score	0.747241 (rank : 559)	θ value	9.92553e-07 (rank : 742)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1059	Shared Neighborhood Hits	1000
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FGFR3_HUMAN
NC score	0.746795 (rank : 560)	θ value	2.61198e-07 (rank : 713)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1042	Shared Neighborhood Hits	995
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

ROCK2_HUMAN
NC score	0.742605 (rank : 561)	θ value	1.80466e-16 (rank : 310)
Query Neighborhood Hits	1762	Target Neighborhood Hits	2073	Shared Neighborhood Hits	884
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

TRIB1_HUMAN
NC score	0.741936 (rank : 562)	θ value	9.92553e-07 (rank : 744)
Query Neighborhood Hits	1762	Target Neighborhood Hits	598	Shared Neighborhood Hits	587
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

JAK2_HUMAN
NC score	0.741828 (rank : 563)	θ value	8.67504e-11 (rank : 554)
Query Neighborhood Hits	1762	Target Neighborhood Hits	847	Shared Neighborhood Hits	813
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

MRCKA_HUMAN
NC score	0.741179 (rank : 564)	θ value	1.52774e-15 (rank : 353)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1999	Shared Neighborhood Hits	883
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

JAK2_MOUSE
NC score	0.741146 (rank : 565)	θ value	1.47974e-10 (rank : 562)
Query Neighborhood Hits	1762	Target Neighborhood Hits	839	Shared Neighborhood Hits	808
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

TRIB1_MOUSE
NC score	0.740393 (rank : 566)	θ value	3.77169e-06 (rank : 760)
Query Neighborhood Hits	1762	Target Neighborhood Hits	593	Shared Neighborhood Hits	585
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

MUSK_HUMAN
NC score	0.740181 (rank : 567)	θ value	9.56915e-18 (rank : 237)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1074	Shared Neighborhood Hits	998
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

FGFR4_HUMAN
NC score	0.739512 (rank : 568)	θ value	7.59969e-07 (rank : 738)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1037	Shared Neighborhood Hits	994
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

JAK3_MOUSE
NC score	0.739044 (rank : 569)	θ value	4.45536e-07 (rank : 720)
Query Neighborhood Hits	1762	Target Neighborhood Hits	821	Shared Neighborhood Hits	795
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

ROCK1_HUMAN
NC score	0.739041 (rank : 570)	θ value	2.13179e-17 (rank : 249)
Query Neighborhood Hits	1762	Target Neighborhood Hits	2000	Shared Neighborhood Hits	881
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

CTRO_HUMAN
NC score	0.738376 (rank : 571)	θ value	1.38178e-16 (rank : 294)
Query Neighborhood Hits	1762	Target Neighborhood Hits	2092	Shared Neighborhood Hits	905
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

CLK3_HUMAN
NC score	0.737960 (rank : 572)	θ value	2.88788e-06 (rank : 755)
Query Neighborhood Hits	1762	Target Neighborhood Hits	748	Shared Neighborhood Hits	733
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK3_MOUSE
NC score	0.737332 (rank : 573)	θ value	2.88788e-06 (rank : 756)
Query Neighborhood Hits	1762	Target Neighborhood Hits	761	Shared Neighborhood Hits	734
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

MUSK_MOUSE
NC score	0.736893 (rank : 574)	θ value	2.35696e-16 (rank : 316)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1057	Shared Neighborhood Hits	989
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

ROCK2_MOUSE
NC score	0.735723 (rank : 575)	θ value	3.07829e-16 (rank : 324)
Query Neighborhood Hits	1762	Target Neighborhood Hits	2072	Shared Neighborhood Hits	884
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

MYO3A_MOUSE
NC score	0.735349 (rank : 576)	θ value	2.43908e-13 (rank : 460)
Query Neighborhood Hits	1762	Target Neighborhood Hits	902	Shared Neighborhood Hits	820
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

PINK1_MOUSE
NC score	0.734775 (rank : 577)	θ value	2.44474e-05 (rank : 810)
Query Neighborhood Hits	1762	Target Neighborhood Hits	726	Shared Neighborhood Hits	713
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

TYK2_HUMAN
NC score	0.734436 (rank : 578)	θ value	6.21693e-09 (rank : 634)
Query Neighborhood Hits	1762	Target Neighborhood Hits	841	Shared Neighborhood Hits	813
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

JAK3_HUMAN
NC score	0.734062 (rank : 579)	θ value	5.26297e-08 (rank : 675)
Query Neighborhood Hits	1762	Target Neighborhood Hits	827	Shared Neighborhood Hits	802
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

NTRK2_MOUSE
NC score	0.733088 (rank : 580)	θ value	1.47974e-10 (rank : 565)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1088	Shared Neighborhood Hits	960
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

NTRK2_HUMAN
NC score	0.733083 (rank : 581)	θ value	1.47974e-10 (rank : 564)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1081	Shared Neighborhood Hits	960
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

PINK1_HUMAN
NC score	0.730085 (rank : 582)	θ value	8.40245e-06 (rank : 778)
Query Neighborhood Hits	1762	Target Neighborhood Hits	741	Shared Neighborhood Hits	716
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

TYK2_MOUSE
NC score	0.729808 (rank : 583)	θ value	8.11959e-09 (rank : 640)
Query Neighborhood Hits	1762	Target Neighborhood Hits	850	Shared Neighborhood Hits	814
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

AL2S2_HUMAN
NC score	0.729780 (rank : 584)	θ value	0.0148317 (rank : 999)
Query Neighborhood Hits	1762	Target Neighborhood Hits	727	Shared Neighborhood Hits	706
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

TRIB3_MOUSE
NC score	0.729530 (rank : 585)	θ value	5.44631e-05 (rank : 831)
Query Neighborhood Hits	1762	Target Neighborhood Hits	578	Shared Neighborhood Hits	571
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

VGFR1_MOUSE
NC score	0.729514 (rank : 586)	θ value	9.26847e-13 (rank : 492)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1118	Shared Neighborhood Hits	1013
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

MRCKB_MOUSE
NC score	0.729088 (rank : 587)	θ value	1.80466e-16 (rank : 302)
Query Neighborhood Hits	1762	Target Neighborhood Hits	2180	Shared Neighborhood Hits	914
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MYO3A_HUMAN
NC score	0.727704 (rank : 588)	θ value	1.09485e-13 (rank : 448)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1033	Shared Neighborhood Hits	836
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

KSR1_MOUSE
NC score	0.725904 (rank : 589)	θ value	0.00020696 (rank : 867)
Query Neighborhood Hits	1762	Target Neighborhood Hits	870	Shared Neighborhood Hits	806
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

VGFR1_HUMAN
NC score	0.724516 (rank : 590)	θ value	6.00763e-12 (rank : 515)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1109	Shared Neighborhood Hits	1011
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

ROCK1_MOUSE
NC score	0.723930 (rank : 591)	θ value	2.13179e-17 (rank : 250)
Query Neighborhood Hits	1762	Target Neighborhood Hits	2126	Shared Neighborhood Hits	893
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

JAK1_HUMAN
NC score	0.723727 (rank : 592)	θ value	1.38499e-08 (rank : 648)
Query Neighborhood Hits	1762	Target Neighborhood Hits	858	Shared Neighborhood Hits	813
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

MYO3B_HUMAN
NC score	0.723322 (rank : 593)	θ value	9.26847e-13 (rank : 487)
Query Neighborhood Hits	1762	Target Neighborhood Hits	923	Shared Neighborhood Hits	837
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

MRCKB_HUMAN
NC score	0.721174 (rank : 594)	θ value	6.85773e-16 (rank : 336)
Query Neighborhood Hits	1762	Target Neighborhood Hits	2239	Shared Neighborhood Hits	929
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

FES_MOUSE
NC score	0.720826 (rank : 595)	θ value	1.38499e-08 (rank : 647)
Query Neighborhood Hits	1762	Target Neighborhood Hits	980	Shared Neighborhood Hits	802
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGFR4_MOUSE
NC score	0.720548 (rank : 596)	θ value	5.26297e-08 (rank : 673)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1026	Shared Neighborhood Hits	981
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

LRRK1_HUMAN
NC score	0.720266 (rank : 597)	θ value	4.45536e-07 (rank : 722)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1237	Shared Neighborhood Hits	830
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

FES_HUMAN
NC score	0.719959 (rank : 598)	θ value	3.64472e-09 (rank : 614)
Query Neighborhood Hits	1762	Target Neighborhood Hits	978	Shared Neighborhood Hits	799
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

LRRK1_MOUSE
NC score	0.718751 (rank : 599)	θ value	1.99992e-07 (rank : 707)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1267	Shared Neighborhood Hits	836
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

CTRO_MOUSE
NC score	0.717228 (rank : 600)	θ value	3.76295e-14 (rank : 429)
Query Neighborhood Hits	1762	Target Neighborhood Hits	2344	Shared Neighborhood Hits	928
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

KSR1_HUMAN
NC score	0.716780 (rank : 601)	θ value	0.000158464 (rank : 858)
Query Neighborhood Hits	1762	Target Neighborhood Hits	867	Shared Neighborhood Hits	793
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

AL2S2_MOUSE
NC score	0.716703 (rank : 602)	θ value	0.0961366 (rank : 1072)
Query Neighborhood Hits	1762	Target Neighborhood Hits	709	Shared Neighborhood Hits	687
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

JAK1_MOUSE
NC score	0.716470 (rank : 603)	θ value	5.81887e-07 (rank : 727)
Query Neighborhood Hits	1762	Target Neighborhood Hits	854	Shared Neighborhood Hits	811
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

PTK6_HUMAN
NC score	0.715910 (rank : 604)	θ value	1.29631e-06 (rank : 751)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1020	Shared Neighborhood Hits	822
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

VGFR2_HUMAN
NC score	0.715199 (rank : 605)	θ value	3.18553e-13 (rank : 470)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1103	Shared Neighborhood Hits	999
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

VGFR2_MOUSE
NC score	0.714781 (rank : 606)	θ value	1.38499e-08 (rank : 652)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1089	Shared Neighborhood Hits	996
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

PTK6_MOUSE
NC score	0.714082 (rank : 607)	θ value	1.06045e-08 (rank : 646)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1026	Shared Neighborhood Hits	822
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

ROR1_MOUSE
NC score	0.713567 (rank : 608)	θ value	3.41135e-07 (rank : 718)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1025	Shared Neighborhood Hits	966
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

ROR1_HUMAN
NC score	0.711982 (rank : 609)	θ value	5.81887e-07 (rank : 735)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1018	Shared Neighborhood Hits	960
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

TYRO3_HUMAN
NC score	0.711721 (rank : 610)	θ value	1.09739e-05 (rank : 785)
Query Neighborhood Hits	1762	Target Neighborhood Hits	995	Shared Neighborhood Hits	934
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

TYRO3_MOUSE
NC score	0.710630 (rank : 611)	θ value	1.09739e-05 (rank : 786)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1007	Shared Neighborhood Hits	939
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

TRIB3_HUMAN
NC score	0.707849 (rank : 612)	θ value	0.000158464 (rank : 860)
Query Neighborhood Hits	1762	Target Neighborhood Hits	519	Shared Neighborhood Hits	514
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

RIPK2_HUMAN
NC score	0.707394 (rank : 613)	θ value	1.87187e-05 (rank : 802)
Query Neighborhood Hits	1762	Target Neighborhood Hits	774	Shared Neighborhood Hits	740
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

TEC_MOUSE
NC score	0.706511 (rank : 614)	θ value	6.64225e-11 (rank : 551)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1006	Shared Neighborhood Hits	816
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

LRRK2_HUMAN
NC score	0.706499 (rank : 615)	θ value	5.62301e-10 (rank : 583)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1382	Shared Neighborhood Hits	845
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

KSYK_MOUSE
NC score	0.705704 (rank : 616)	θ value	7.59969e-07 (rank : 739)
Query Neighborhood Hits	1762	Target Neighborhood Hits	944	Shared Neighborhood Hits	810
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_HUMAN
NC score	0.705472 (rank : 617)	θ value	6.43352e-06 (rank : 772)
Query Neighborhood Hits	1762	Target Neighborhood Hits	901	Shared Neighborhood Hits	797
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

ZAP70_HUMAN
NC score	0.705466 (rank : 618)	θ value	4.45536e-07 (rank : 725)
Query Neighborhood Hits	1762	Target Neighborhood Hits	893	Shared Neighborhood Hits	802
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

RIPK2_MOUSE
NC score	0.705336 (rank : 619)	θ value	1.87187e-05 (rank : 803)
Query Neighborhood Hits	1762	Target Neighborhood Hits	776	Shared Neighborhood Hits	740
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

ZAP70_MOUSE
NC score	0.703574 (rank : 620)	θ value	8.97725e-08 (rank : 691)
Query Neighborhood Hits	1762	Target Neighborhood Hits	905	Shared Neighborhood Hits	807
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

FAK1_HUMAN
NC score	0.703435 (rank : 621)	θ value	1.133e-10 (rank : 560)
Query Neighborhood Hits	1762	Target Neighborhood Hits	850	Shared Neighborhood Hits	808
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
NC score	0.703054 (rank : 622)	θ value	1.133e-10 (rank : 561)
Query Neighborhood Hits	1762	Target Neighborhood Hits	850	Shared Neighborhood Hits	808
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

CSK_MOUSE
NC score	0.702283 (rank : 623)	θ value	6.21693e-09 (rank : 626)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1009	Shared Neighborhood Hits	822
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

ROR2_HUMAN
NC score	0.702139 (rank : 624)	θ value	6.87365e-08 (rank : 681)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1014	Shared Neighborhood Hits	945
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

NTRK3_HUMAN
NC score	0.701778 (rank : 625)	θ value	1.09739e-05 (rank : 783)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1115	Shared Neighborhood Hits	946
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

TEC_HUMAN
NC score	0.701469 (rank : 626)	θ value	7.84624e-12 (rank : 520)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1006	Shared Neighborhood Hits	814
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

FER_HUMAN
NC score	0.700678 (rank : 627)	θ value	1.53129e-07 (rank : 700)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1278	Shared Neighborhood Hits	806
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

RPKL1_MOUSE
NC score	0.699107 (rank : 628)	θ value	0.00175202 (rank : 931)
Query Neighborhood Hits	1762	Target Neighborhood Hits	704	Shared Neighborhood Hits	667
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

TXK_HUMAN
NC score	0.698796 (rank : 629)	θ value	1.38499e-08 (rank : 651)
Query Neighborhood Hits	1762	Target Neighborhood Hits	971	Shared Neighborhood Hits	806
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

VGFR3_MOUSE
NC score	0.698154 (rank : 630)	θ value	1.38499e-08 (rank : 653)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1056	Shared Neighborhood Hits	978
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

RPKL1_HUMAN
NC score	0.696817 (rank : 631)	θ value	0.000158464 (rank : 859)
Query Neighborhood Hits	1762	Target Neighborhood Hits	708	Shared Neighborhood Hits	660
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

BMX_HUMAN
NC score	0.696179 (rank : 632)	θ value	2.36244e-08 (rank : 659)
Query Neighborhood Hits	1762	Target Neighborhood Hits	942	Shared Neighborhood Hits	796
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

SRMS_MOUSE
NC score	0.696124 (rank : 633)	θ value	2.43908e-13 (rank : 461)
Query Neighborhood Hits	1762	Target Neighborhood Hits	964	Shared Neighborhood Hits	818
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

BMX_MOUSE
NC score	0.695457 (rank : 634)	θ value	6.21693e-09 (rank : 625)
Query Neighborhood Hits	1762	Target Neighborhood Hits	912	Shared Neighborhood Hits	787
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

ABL1_MOUSE
NC score	0.695433 (rank : 635)	θ value	0.00020696 (rank : 864)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1178	Shared Neighborhood Hits	895
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

MATK_MOUSE
NC score	0.694720 (rank : 636)	θ value	1.38499e-08 (rank : 649)
Query Neighborhood Hits	1762	Target Neighborhood Hits	952	Shared Neighborhood Hits	823
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

ITK_MOUSE
NC score	0.694670 (rank : 637)	θ value	8.97725e-08 (rank : 686)
Query Neighborhood Hits	1762	Target Neighborhood Hits	985	Shared Neighborhood Hits	814
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

VGFR3_HUMAN
NC score	0.694478 (rank : 638)	θ value	1.80886e-08 (rank : 658)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1037	Shared Neighborhood Hits	972
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

CSK_HUMAN
NC score	0.694414 (rank : 639)	θ value	2.36244e-08 (rank : 660)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1009	Shared Neighborhood Hits	821
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

ITK_HUMAN
NC score	0.694184 (rank : 640)	θ value	2.61198e-07 (rank : 715)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1016	Shared Neighborhood Hits	818
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

TIE2_HUMAN
NC score	0.694048 (rank : 641)	θ value	8.40245e-06 (rank : 780)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1192	Shared Neighborhood Hits	888
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE2_MOUSE
NC score	0.693820 (rank : 642)	θ value	1.09739e-05 (rank : 784)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1204	Shared Neighborhood Hits	889
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

ABL1_HUMAN
NC score	0.693678 (rank : 643)	θ value	0.000158464 (rank : 856)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1220	Shared Neighborhood Hits	896
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

BTK_HUMAN
NC score	0.693267 (rank : 644)	θ value	1.2105e-12 (rank : 493)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1026	Shared Neighborhood Hits	818
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
NC score	0.692796 (rank : 645)	θ value	1.58096e-12 (rank : 496)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1017	Shared Neighborhood Hits	818
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

LYN_MOUSE
NC score	0.692121 (rank : 646)	θ value	8.11959e-09 (rank : 637)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1023	Shared Neighborhood Hits	837
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

TTBK1_HUMAN
NC score	0.691617 (rank : 647)	θ value	0.000270298 (rank : 872)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1058	Shared Neighborhood Hits	814
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

FRK_HUMAN
NC score	0.691371 (rank : 648)	θ value	8.97725e-08 (rank : 685)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1058	Shared Neighborhood Hits	829
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

LYN_HUMAN
NC score	0.690903 (rank : 649)	θ value	1.80886e-08 (rank : 656)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1022	Shared Neighborhood Hits	834
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

FAK2_MOUSE
NC score	0.690451 (rank : 650)	θ value	3.19293e-05 (rank : 815)
Query Neighborhood Hits	1762	Target Neighborhood Hits	851	Shared Neighborhood Hits	788
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

MATK_HUMAN
NC score	0.690267 (rank : 651)	θ value	4.0297e-08 (rank : 666)
Query Neighborhood Hits	1762	Target Neighborhood Hits	954	Shared Neighborhood Hits	818
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

LRRK2_MOUSE
NC score	0.689952 (rank : 652)	θ value	4.76016e-09 (rank : 623)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1359	Shared Neighborhood Hits	834
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

SRMS_HUMAN
NC score	0.689740 (rank : 653)	θ value	8.67504e-11 (rank : 558)
Query Neighborhood Hits	1762	Target Neighborhood Hits	946	Shared Neighborhood Hits	817
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

ABL2_HUMAN
NC score	0.689078 (rank : 654)	θ value	0.000270298 (rank : 869)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1045	Shared Neighborhood Hits	826
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

IRAK1_HUMAN
NC score	0.686781 (rank : 655)	θ value	1.06291 (rank : 1269)
Query Neighborhood Hits	1762	Target Neighborhood Hits	820	Shared Neighborhood Hits	767
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

TXK_MOUSE
NC score	0.686763 (rank : 656)	θ value	3.64472e-09 (rank : 620)
Query Neighborhood Hits	1762	Target Neighborhood Hits	980	Shared Neighborhood Hits	804
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

CDC7_HUMAN
NC score	0.686091 (rank : 657)	θ value	0.00665767 (rank : 964)
Query Neighborhood Hits	1762	Target Neighborhood Hits	652	Shared Neighborhood Hits	632
SwissProt Accessions	O00311, O00558	Gene names	CDC7, CDC7L1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (HsCdc7) (huCdc7).

FAK2_HUMAN
NC score	0.685532 (rank : 658)	θ value	3.19293e-05 (rank : 814)
Query Neighborhood Hits	1762	Target Neighborhood Hits	847	Shared Neighborhood Hits	785
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

UFO_MOUSE
NC score	0.684590 (rank : 659)	θ value	0.00665767 (rank : 978)
Query Neighborhood Hits	1762	Target Neighborhood Hits	988	Shared Neighborhood Hits	893
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

TNK1_MOUSE
NC score	0.684149 (rank : 660)	θ value	9.92553e-07 (rank : 743)
Query Neighborhood Hits	1762	Target Neighborhood Hits	806	Shared Neighborhood Hits	770
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

LCK_MOUSE
NC score	0.683350 (rank : 661)	θ value	8.11959e-09 (rank : 636)
Query Neighborhood Hits	1762	Target Neighborhood Hits	981	Shared Neighborhood Hits	822
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

TIE1_MOUSE
NC score	0.683061 (rank : 662)	θ value	9.29e-05 (rank : 847)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1266	Shared Neighborhood Hits	923
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

CDC7_MOUSE
NC score	0.682832 (rank : 663)	θ value	0.000270298 (rank : 870)
Query Neighborhood Hits	1762	Target Neighborhood Hits	641	Shared Neighborhood Hits	629
SwissProt Accessions	Q9Z0H0, Q9Z2Y7	Gene names	Cdc7, Cdc7l1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (muCdc7).

EPHA5_MOUSE
NC score	0.682146 (rank : 664)	θ value	1.87187e-05 (rank : 800)
Query Neighborhood Hits	1762	Target Neighborhood Hits	950	Shared Neighborhood Hits	857
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

IRAK1_MOUSE
NC score	0.681658 (rank : 665)	θ value	3.0926 (rank : 1466)
Query Neighborhood Hits	1762	Target Neighborhood Hits	784	Shared Neighborhood Hits	740
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

ROR2_MOUSE
NC score	0.681527 (rank : 666)	θ value	4.0297e-08 (rank : 669)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1000	Shared Neighborhood Hits	925
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

ACK1_HUMAN
NC score	0.680214 (rank : 667)	θ value	7.84624e-12 (rank : 516)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1140	Shared Neighborhood Hits	934
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

EPHB1_HUMAN
NC score	0.679031 (rank : 668)	θ value	6.43352e-06 (rank : 770)
Query Neighborhood Hits	1762	Target Neighborhood Hits	988	Shared Neighborhood Hits	861
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

LCK_HUMAN
NC score	0.678883 (rank : 669)	θ value	4.76016e-09 (rank : 622)
Query Neighborhood Hits	1762	Target Neighborhood Hits	987	Shared Neighborhood Hits	825
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

MERTK_MOUSE
NC score	0.678508 (rank : 670)	θ value	0.000461057 (rank : 888)
Query Neighborhood Hits	1762	Target Neighborhood Hits	974	Shared Neighborhood Hits	897
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

ACK1_MOUSE
NC score	0.678367 (rank : 671)	θ value	1.33837e-11 (rank : 530)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1080	Shared Neighborhood Hits	918
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

TTBK2_HUMAN
NC score	0.678367 (rank : 672)	θ value	0.000158464 (rank : 861)
Query Neighborhood Hits	1762	Target Neighborhood Hits	822	Shared Neighborhood Hits	734
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

TIE1_HUMAN
NC score	0.678079 (rank : 673)	θ value	9.29e-05 (rank : 846)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1241	Shared Neighborhood Hits	908
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

BLK_HUMAN
NC score	0.677719 (rank : 674)	θ value	1.29631e-06 (rank : 745)
Query Neighborhood Hits	1762	Target Neighborhood Hits	994	Shared Neighborhood Hits	823
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

EPHA7_HUMAN
NC score	0.677694 (rank : 675)	θ value	4.92598e-06 (rank : 764)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1053	Shared Neighborhood Hits	873
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

UFO_HUMAN
NC score	0.677674 (rank : 676)	θ value	0.00665767 (rank : 977)
Query Neighborhood Hits	1762	Target Neighborhood Hits	981	Shared Neighborhood Hits	895
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

EPHA7_MOUSE
NC score	0.677393 (rank : 677)	θ value	6.43352e-06 (rank : 769)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1025	Shared Neighborhood Hits	872
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

HCK_HUMAN
NC score	0.677229 (rank : 678)	θ value	3.64472e-09 (rank : 616)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1035	Shared Neighborhood Hits	829
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

TNK1_HUMAN
NC score	0.676668 (rank : 679)	θ value	2.61198e-07 (rank : 716)
Query Neighborhood Hits	1762	Target Neighborhood Hits	815	Shared Neighborhood Hits	776
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

EPHA3_HUMAN
NC score	0.676552 (rank : 680)	θ value	1.87187e-05 (rank : 798)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1005	Shared Neighborhood Hits	883
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

BLK_MOUSE
NC score	0.676329 (rank : 681)	θ value	5.26297e-08 (rank : 670)
Query Neighborhood Hits	1762	Target Neighborhood Hits	992	Shared Neighborhood Hits	821
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

FYN_HUMAN
NC score	0.675551 (rank : 682)	θ value	4.45536e-07 (rank : 719)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1078	Shared Neighborhood Hits	833
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

TTBK2_MOUSE
NC score	0.674898 (rank : 683)	θ value	0.000270298 (rank : 873)
Query Neighborhood Hits	1762	Target Neighborhood Hits	811	Shared Neighborhood Hits	720
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

MERTK_HUMAN
NC score	0.673476 (rank : 684)	θ value	0.00134147 (rank : 923)
Query Neighborhood Hits	1762	Target Neighborhood Hits	988	Shared Neighborhood Hits	915
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

EPHB4_MOUSE
NC score	0.673150 (rank : 685)	θ value	0.000121331 (rank : 850)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1013	Shared Neighborhood Hits	861
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

RET_HUMAN
NC score	0.672620 (rank : 686)	θ value	6.43352e-06 (rank : 773)
Query Neighborhood Hits	1762	Target Neighborhood Hits	873	Shared Neighborhood Hits	792
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

HCK_MOUSE
NC score	0.672325 (rank : 687)	θ value	5.26297e-08 (rank : 674)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1029	Shared Neighborhood Hits	825
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

KS6C1_MOUSE
NC score	0.672284 (rank : 688)	θ value	0.279714 (rank : 1144)
Query Neighborhood Hits	1762	Target Neighborhood Hits	700	Shared Neighborhood Hits	640
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

KC1A_HUMAN
NC score	0.672224 (rank : 689)	θ value	0.00134147 (rank : 920)
Query Neighborhood Hits	1762	Target Neighborhood Hits	728	Shared Neighborhood Hits	724
SwissProt Accessions	P48729, Q96HD2	Gene names	CSNK1A1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1A_MOUSE
NC score	0.672224 (rank : 690)	θ value	0.00134147 (rank : 921)
Query Neighborhood Hits	1762	Target Neighborhood Hits	728	Shared Neighborhood Hits	724
SwissProt Accessions	Q8BK63, Q3UIL0, Q64506, Q80XI2, Q99LY3	Gene names	Csnk1a1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

RET_MOUSE
NC score	0.671380 (rank : 691)	θ value	3.19293e-05 (rank : 817)
Query Neighborhood Hits	1762	Target Neighborhood Hits	884	Shared Neighborhood Hits	792
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

SRC_MOUSE
NC score	0.671128 (rank : 692)	θ value	2.36244e-08 (rank : 663)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1033	Shared Neighborhood Hits	821
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

FYN_MOUSE
NC score	0.670500 (rank : 693)	θ value	1.29631e-06 (rank : 748)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1073	Shared Neighborhood Hits	834
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

EPHA5_HUMAN
NC score	0.670287 (rank : 694)	θ value	1.87187e-05 (rank : 799)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1009	Shared Neighborhood Hits	870
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

SRC_HUMAN
NC score	0.670191 (rank : 695)	θ value	2.36244e-08 (rank : 662)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1058	Shared Neighborhood Hits	823
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

EPHA3_MOUSE
NC score	0.670191 (rank : 696)	θ value	0.000602161 (rank : 894)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1009	Shared Neighborhood Hits	890
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

ROS_HUMAN
NC score	0.670076 (rank : 697)	θ value	0.000786445 (rank : 903)
Query Neighborhood Hits	1762	Target Neighborhood Hits	907	Shared Neighborhood Hits	823
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

KC1AL_HUMAN
NC score	0.669424 (rank : 698)	θ value	0.000786445 (rank : 901)
Query Neighborhood Hits	1762	Target Neighborhood Hits	734	Shared Neighborhood Hits	723
SwissProt Accessions	Q8N752	Gene names	CSNK1A1L
Domain Architecture
Description	Casein kinase I isoform alpha-like (EC 2.7.11.1) (CKI-alpha-like) (CK1).

PGFRA_HUMAN
NC score	0.669002 (rank : 699)	θ value	2.44474e-05 (rank : 808)
Query Neighborhood Hits	1762	Target Neighborhood Hits	980	Shared Neighborhood Hits	925
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

EPHB4_HUMAN
NC score	0.668678 (rank : 700)	θ value	0.000121331 (rank : 849)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1056	Shared Neighborhood Hits	867
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

KS6C1_HUMAN
NC score	0.668279 (rank : 701)	θ value	0.21417 (rank : 1126)
Query Neighborhood Hits	1762	Target Neighborhood Hits	682	Shared Neighborhood Hits	636
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

KC1D_MOUSE
NC score	0.667885 (rank : 702)	θ value	0.00102713 (rank : 912)
Query Neighborhood Hits	1762	Target Neighborhood Hits	737	Shared Neighborhood Hits	723
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_HUMAN
NC score	0.667874 (rank : 703)	θ value	0.00102713 (rank : 911)
Query Neighborhood Hits	1762	Target Neighborhood Hits	737	Shared Neighborhood Hits	723
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

EPHA2_HUMAN
NC score	0.666764 (rank : 704)	θ value	3.77169e-06 (rank : 758)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1021	Shared Neighborhood Hits	868
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

YES_HUMAN
NC score	0.666613 (rank : 705)	θ value	4.45536e-07 (rank : 724)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1059	Shared Neighborhood Hits	824
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

PGFRA_MOUSE
NC score	0.666229 (rank : 706)	θ value	2.44474e-05 (rank : 809)
Query Neighborhood Hits	1762	Target Neighborhood Hits	975	Shared Neighborhood Hits	922
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

YES_MOUSE
NC score	0.665926 (rank : 707)	θ value	5.81887e-07 (rank : 737)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1052	Shared Neighborhood Hits	819
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

EPHA4_MOUSE
NC score	0.665910 (rank : 708)	θ value	4.92598e-06 (rank : 763)
Query Neighborhood Hits	1762	Target Neighborhood Hits	982	Shared Neighborhood Hits	867
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

NTRK1_HUMAN
NC score	0.664978 (rank : 709)	θ value	1.29631e-06 (rank : 750)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1023	Shared Neighborhood Hits	877
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

EPHA4_HUMAN
NC score	0.664956 (rank : 710)	θ value	4.92598e-06 (rank : 762)
Query Neighborhood Hits	1762	Target Neighborhood Hits	975	Shared Neighborhood Hits	865
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

KC1E_HUMAN
NC score	0.664782 (rank : 711)	θ value	0.00102713 (rank : 913)
Query Neighborhood Hits	1762	Target Neighborhood Hits	732	Shared Neighborhood Hits	722
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

EPHA8_HUMAN
NC score	0.664765 (rank : 712)	θ value	9.29e-05 (rank : 838)
Query Neighborhood Hits	1762	Target Neighborhood Hits	956	Shared Neighborhood Hits	864
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

KC1E_MOUSE
NC score	0.664757 (rank : 713)	θ value	0.00102713 (rank : 914)
Query Neighborhood Hits	1762	Target Neighborhood Hits	728	Shared Neighborhood Hits	721
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1G1_MOUSE
NC score	0.664536 (rank : 714)	θ value	2.36244e-08 (rank : 661)
Query Neighborhood Hits	1762	Target Neighborhood Hits	713	Shared Neighborhood Hits	703
SwissProt Accessions	Q8BTH8	Gene names	Csnk1g1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

EPHA2_MOUSE
NC score	0.664118 (rank : 715)	θ value	2.21117e-06 (rank : 752)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1020	Shared Neighborhood Hits	860
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHB2_MOUSE
NC score	0.662718 (rank : 716)	θ value	5.44631e-05 (rank : 826)
Query Neighborhood Hits	1762	Target Neighborhood Hits	982	Shared Neighborhood Hits	855
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

KC1G1_HUMAN
NC score	0.662524 (rank : 717)	θ value	1.17247e-07 (rank : 694)
Query Neighborhood Hits	1762	Target Neighborhood Hits	708	Shared Neighborhood Hits	701
SwissProt Accessions	Q9HCP0, Q96AE9, Q9HCP1	Gene names	CSNK1G1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

EPHB2_HUMAN
NC score	0.662513 (rank : 718)	θ value	5.44631e-05 (rank : 825)
Query Neighborhood Hits	1762	Target Neighborhood Hits	983	Shared Neighborhood Hits	855
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

ERBB4_HUMAN
NC score	0.662351 (rank : 719)	θ value	0.000461057 (rank : 883)
Query Neighborhood Hits	1762	Target Neighborhood Hits	910	Shared Neighborhood Hits	801
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

EPHA8_MOUSE
NC score	0.661830 (rank : 720)	θ value	2.44474e-05 (rank : 805)
Query Neighborhood Hits	1762	Target Neighborhood Hits	969	Shared Neighborhood Hits	864
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

STYK1_HUMAN
NC score	0.661573 (rank : 721)	θ value	2.44474e-05 (rank : 813)
Query Neighborhood Hits	1762	Target Neighborhood Hits	786	Shared Neighborhood Hits	760
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

EGFR_MOUSE
NC score	0.661566 (rank : 722)	θ value	0.000602161 (rank : 893)
Query Neighborhood Hits	1762	Target Neighborhood Hits	927	Shared Neighborhood Hits	806
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

FGR_HUMAN
NC score	0.661479 (rank : 723)	θ value	8.97725e-08 (rank : 683)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1067	Shared Neighborhood Hits	828
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

EGFR_HUMAN
NC score	0.661017 (rank : 724)	θ value	0.000602161 (rank : 892)
Query Neighborhood Hits	1762	Target Neighborhood Hits	939	Shared Neighborhood Hits	799
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EPHB3_HUMAN
NC score	0.660899 (rank : 725)	θ value	2.61198e-07 (rank : 711)
Query Neighborhood Hits	1762	Target Neighborhood Hits	996	Shared Neighborhood Hits	870
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHB3_MOUSE
NC score	0.659664 (rank : 726)	θ value	2.61198e-07 (rank : 712)
Query Neighborhood Hits	1762	Target Neighborhood Hits	996	Shared Neighborhood Hits	870
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

KC1G3_HUMAN
NC score	0.659091 (rank : 727)	θ value	1.53129e-07 (rank : 701)
Query Neighborhood Hits	1762	Target Neighborhood Hits	711	Shared Neighborhood Hits	706
SwissProt Accessions	Q9Y6M4, Q86WZ7, Q9Y6M3	Gene names	CSNK1G3
Domain Architecture
Description	Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma 3).

RON_HUMAN
NC score	0.659037 (rank : 728)	θ value	1.17247e-07 (rank : 698)
Query Neighborhood Hits	1762	Target Neighborhood Hits	842	Shared Neighborhood Hits	792
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

PGFRB_MOUSE
NC score	0.658574 (rank : 729)	θ value	1.87187e-05 (rank : 801)
Query Neighborhood Hits	1762	Target Neighborhood Hits	960	Shared Neighborhood Hits	911
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

FGR_MOUSE
NC score	0.658515 (rank : 730)	θ value	8.97725e-08 (rank : 684)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1069	Shared Neighborhood Hits	825
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

TNI3K_MOUSE
NC score	0.655056 (rank : 731)	θ value	0.00228821 (rank : 938)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1079	Shared Neighborhood Hits	788
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

PGFRB_HUMAN
NC score	0.654602 (rank : 732)	θ value	2.21117e-06 (rank : 753)
Query Neighborhood Hits	1762	Target Neighborhood Hits	962	Shared Neighborhood Hits	915
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

ERBB2_MOUSE
NC score	0.653616 (rank : 733)	θ value	4.1701e-05 (rank : 819)
Query Neighborhood Hits	1762	Target Neighborhood Hits	918	Shared Neighborhood Hits	816
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

EPHA1_HUMAN
NC score	0.652446 (rank : 734)	θ value	2.61198e-07 (rank : 709)
Query Neighborhood Hits	1762	Target Neighborhood Hits	997	Shared Neighborhood Hits	842
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

MET_MOUSE
NC score	0.651897 (rank : 735)	θ value	1.43324e-05 (rank : 793)
Query Neighborhood Hits	1762	Target Neighborhood Hits	844	Shared Neighborhood Hits	786
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

INSR_HUMAN
NC score	0.650946 (rank : 736)	θ value	1.43324e-05 (rank : 792)
Query Neighborhood Hits	1762	Target Neighborhood Hits	963	Shared Neighborhood Hits	833
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

ERBB2_HUMAN
NC score	0.650936 (rank : 737)	θ value	5.44631e-05 (rank : 827)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1073	Shared Neighborhood Hits	849
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

INSR_MOUSE
NC score	0.650586 (rank : 738)	θ value	6.43352e-06 (rank : 771)
Query Neighborhood Hits	1762	Target Neighborhood Hits	968	Shared Neighborhood Hits	826
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

KIT_HUMAN
NC score	0.650397 (rank : 739)	θ value	5.44631e-05 (rank : 829)
Query Neighborhood Hits	1762	Target Neighborhood Hits	953	Shared Neighborhood Hits	909
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

AVR2A_MOUSE
NC score	0.650224 (rank : 740)	θ value	1.87187e-05 (rank : 795)
Query Neighborhood Hits	1762	Target Neighborhood Hits	767	Shared Neighborhood Hits	750
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

AVR2A_HUMAN
NC score	0.650208 (rank : 741)	θ value	1.87187e-05 (rank : 794)
Query Neighborhood Hits	1762	Target Neighborhood Hits	767	Shared Neighborhood Hits	750
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

MET_HUMAN
NC score	0.649809 (rank : 742)	θ value	2.44474e-05 (rank : 807)
Query Neighborhood Hits	1762	Target Neighborhood Hits	831	Shared Neighborhood Hits	782
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

KIT_MOUSE
NC score	0.649638 (rank : 743)	θ value	9.29e-05 (rank : 842)
Query Neighborhood Hits	1762	Target Neighborhood Hits	949	Shared Neighborhood Hits	913
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

TNI3K_HUMAN
NC score	0.648678 (rank : 744)	θ value	0.00102713 (rank : 916)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1084	Shared Neighborhood Hits	792
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

AATK_HUMAN
NC score	0.648128 (rank : 745)	θ value	0.00390308 (rank : 949)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1243	Shared Neighborhood Hits	905
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

RON_MOUSE
NC score	0.648099 (rank : 746)	θ value	5.81887e-07 (rank : 734)
Query Neighborhood Hits	1762	Target Neighborhood Hits	836	Shared Neighborhood Hits	784
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

STYK1_MOUSE
NC score	0.647905 (rank : 747)	θ value	2.21117e-06 (rank : 754)
Query Neighborhood Hits	1762	Target Neighborhood Hits	779	Shared Neighborhood Hits	753
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

DDR2_MOUSE
NC score	0.646901 (rank : 748)	θ value	6.43352e-06 (rank : 768)
Query Neighborhood Hits	1762	Target Neighborhood Hits	813	Shared Neighborhood Hits	763
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

EPHA1_MOUSE
NC score	0.644070 (rank : 749)	θ value	2.61198e-07 (rank : 710)
Query Neighborhood Hits	1762	Target Neighborhood Hits	958	Shared Neighborhood Hits	835
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

DDR2_HUMAN
NC score	0.641266 (rank : 750)	θ value	1.29631e-06 (rank : 746)
Query Neighborhood Hits	1762	Target Neighborhood Hits	818	Shared Neighborhood Hits	763
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

CSF1R_MOUSE
NC score	0.638315 (rank : 751)	θ value	0.000158464 (rank : 857)
Query Neighborhood Hits	1762	Target Neighborhood Hits	983	Shared Neighborhood Hits	927
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

TGFR2_MOUSE
NC score	0.637518 (rank : 752)	θ value	0.0113563 (rank : 996)
Query Neighborhood Hits	1762	Target Neighborhood Hits	748	Shared Neighborhood Hits	729
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TGFR2_HUMAN
NC score	0.637411 (rank : 753)	θ value	0.0113563 (rank : 995)
Query Neighborhood Hits	1762	Target Neighborhood Hits	748	Shared Neighborhood Hits	728
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

AVR2B_MOUSE
NC score	0.636755 (rank : 754)	θ value	1.43324e-05 (rank : 791)
Query Neighborhood Hits	1762	Target Neighborhood Hits	749	Shared Neighborhood Hits	729
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AATK_MOUSE
NC score	0.636627 (rank : 755)	θ value	0.00035302 (rank : 874)
Query Neighborhood Hits	1762	Target Neighborhood Hits	942	Shared Neighborhood Hits	814
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

AVR2B_HUMAN
NC score	0.636625 (rank : 756)	θ value	1.43324e-05 (rank : 790)
Query Neighborhood Hits	1762	Target Neighborhood Hits	748	Shared Neighborhood Hits	729
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

INSRR_MOUSE
NC score	0.635597 (rank : 757)	θ value	9.29e-05 (rank : 841)
Query Neighborhood Hits	1762	Target Neighborhood Hits	961	Shared Neighborhood Hits	811
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

KC1G2_MOUSE
NC score	0.634543 (rank : 758)	θ value	1.29631e-06 (rank : 749)
Query Neighborhood Hits	1762	Target Neighborhood Hits	695	Shared Neighborhood Hits	687
SwissProt Accessions	Q8BVP5	Gene names	Csnk1g2
Domain Architecture	No domain graphic available
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

KC1G2_HUMAN
NC score	0.633468 (rank : 759)	θ value	5.81887e-07 (rank : 728)
Query Neighborhood Hits	1762	Target Neighborhood Hits	693	Shared Neighborhood Hits	687
SwissProt Accessions	P78368, O00704, Q8WUB1	Gene names	CSNK1G2
Domain Architecture
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

IGF1R_MOUSE
NC score	0.633314 (rank : 760)	θ value	9.29e-05 (rank : 840)
Query Neighborhood Hits	1762	Target Neighborhood Hits	973	Shared Neighborhood Hits	822
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

INSRR_HUMAN
NC score	0.632462 (rank : 761)	θ value	0.000461057 (rank : 884)
Query Neighborhood Hits	1762	Target Neighborhood Hits	950	Shared Neighborhood Hits	809
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

IGF1R_HUMAN
NC score	0.631401 (rank : 762)	θ value	9.29e-05 (rank : 839)
Query Neighborhood Hits	1762	Target Neighborhood Hits	977	Shared Neighborhood Hits	823
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

ACVR1_MOUSE
NC score	0.628336 (rank : 763)	θ value	0.0113563 (rank : 990)
Query Neighborhood Hits	1762	Target Neighborhood Hits	768	Shared Neighborhood Hits	747
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

IRAK2_HUMAN
NC score	0.627175 (rank : 764)	θ value	1.38821 (rank : 1318)
Query Neighborhood Hits	1762	Target Neighborhood Hits	714	Shared Neighborhood Hits	678
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

ERBB3_MOUSE
NC score	0.627125 (rank : 765)	θ value	0.000121331 (rank : 851)
Query Neighborhood Hits	1762	Target Neighborhood Hits	898	Shared Neighborhood Hits	773
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

MLKL_MOUSE
NC score	0.625091 (rank : 766)	θ value	1.38821 (rank : 1323)
Query Neighborhood Hits	1762	Target Neighborhood Hits	707	Shared Neighborhood Hits	681
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

ERBB3_HUMAN
NC score	0.623455 (rank : 767)	θ value	5.44631e-05 (rank : 828)
Query Neighborhood Hits	1762	Target Neighborhood Hits	918	Shared Neighborhood Hits	772
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ACVR1_HUMAN
NC score	0.622164 (rank : 768)	θ value	0.0148317 (rank : 998)
Query Neighborhood Hits	1762	Target Neighborhood Hits	760	Shared Neighborhood Hits	741
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

CSF1R_HUMAN
NC score	0.621704 (rank : 769)	θ value	0.00020696 (rank : 865)
Query Neighborhood Hits	1762	Target Neighborhood Hits	943	Shared Neighborhood Hits	898
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

FLT3_MOUSE
NC score	0.618880 (rank : 770)	θ value	0.00035302 (rank : 876)
Query Neighborhood Hits	1762	Target Neighborhood Hits	847	Shared Neighborhood Hits	826
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

SCYL2_HUMAN
NC score	0.618705 (rank : 771)	θ value	7.1131e-05 (rank : 837)
Query Neighborhood Hits	1762	Target Neighborhood Hits	632	Shared Neighborhood Hits	564
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

DDR1_MOUSE
NC score	0.617706 (rank : 772)	θ value	0.00102713 (rank : 906)
Query Neighborhood Hits	1762	Target Neighborhood Hits	818	Shared Neighborhood Hits	762
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR1_HUMAN
NC score	0.615484 (rank : 773)	θ value	0.00134147 (rank : 918)
Query Neighborhood Hits	1762	Target Neighborhood Hits	819	Shared Neighborhood Hits	763
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

BMR1A_HUMAN
NC score	0.615333 (rank : 774)	θ value	0.0563607 (rank : 1051)
Query Neighborhood Hits	1762	Target Neighborhood Hits	759	Shared Neighborhood Hits	735
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

BMR1A_MOUSE
NC score	0.614377 (rank : 775)	θ value	0.0563607 (rank : 1052)
Query Neighborhood Hits	1762	Target Neighborhood Hits	758	Shared Neighborhood Hits	735
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

FLT3_HUMAN
NC score	0.614065 (rank : 776)	θ value	0.00035302 (rank : 875)
Query Neighborhood Hits	1762	Target Neighborhood Hits	843	Shared Neighborhood Hits	819
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

EPHA6_MOUSE
NC score	0.612841 (rank : 777)	θ value	0.000461057 (rank : 882)
Query Neighborhood Hits	1762	Target Neighborhood Hits	946	Shared Neighborhood Hits	842
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

ALK_HUMAN
NC score	0.612545 (rank : 778)	θ value	1.43324e-05 (rank : 789)
Query Neighborhood Hits	1762	Target Neighborhood Hits	795	Shared Neighborhood Hits	732
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

EPHA6_HUMAN
NC score	0.611103 (rank : 779)	θ value	0.000461057 (rank : 881)
Query Neighborhood Hits	1762	Target Neighborhood Hits	959	Shared Neighborhood Hits	847
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

ALK_MOUSE
NC score	0.610317 (rank : 780)	θ value	4.1701e-05 (rank : 818)
Query Neighborhood Hits	1762	Target Neighborhood Hits	811	Shared Neighborhood Hits	743
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

LTK_MOUSE
NC score	0.609419 (rank : 781)	θ value	9.29e-05 (rank : 843)
Query Neighborhood Hits	1762	Target Neighborhood Hits	770	Shared Neighborhood Hits	732
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

TGFR1_HUMAN
NC score	0.605619 (rank : 782)	θ value	0.125558 (rank : 1101)
Query Neighborhood Hits	1762	Target Neighborhood Hits	755	Shared Neighborhood Hits	734
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
NC score	0.605312 (rank : 783)	θ value	0.125558 (rank : 1102)
Query Neighborhood Hits	1762	Target Neighborhood Hits	753	Shared Neighborhood Hits	734
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

LTK_HUMAN
NC score	0.604293 (rank : 784)	θ value	8.40245e-06 (rank : 777)
Query Neighborhood Hits	1762	Target Neighborhood Hits	774	Shared Neighborhood Hits	740
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

BMR1B_MOUSE
NC score	0.600308 (rank : 785)	θ value	θ > 10 (rank : 1772)
Query Neighborhood Hits	1762	Target Neighborhood Hits	758	Shared Neighborhood Hits	736
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

ACV1B_MOUSE
NC score	0.600050 (rank : 786)	θ value	4.03905 (rank : 1492)
Query Neighborhood Hits	1762	Target Neighborhood Hits	753	Shared Neighborhood Hits	735
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

ACV1B_HUMAN
NC score	0.599788 (rank : 787)	θ value	4.03905 (rank : 1491)
Query Neighborhood Hits	1762	Target Neighborhood Hits	753	Shared Neighborhood Hits	735
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

BMR1B_HUMAN
NC score	0.598954 (rank : 788)	θ value	θ > 10 (rank : 1771)
Query Neighborhood Hits	1762	Target Neighborhood Hits	760	Shared Neighborhood Hits	735
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

SCYL2_MOUSE
NC score	0.598892 (rank : 789)	θ value	9.29e-05 (rank : 845)
Query Neighborhood Hits	1762	Target Neighborhood Hits	603	Shared Neighborhood Hits	541
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

ANKK1_MOUSE
NC score	0.598233 (rank : 790)	θ value	0.000121331 (rank : 848)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1072	Shared Neighborhood Hits	788
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

BMPR2_HUMAN
NC score	0.591717 (rank : 791)	θ value	0.365318 (rank : 1153)
Query Neighborhood Hits	1762	Target Neighborhood Hits	736	Shared Neighborhood Hits	696
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

BMPR2_MOUSE
NC score	0.591007 (rank : 792)	θ value	0.125558 (rank : 1086)
Query Neighborhood Hits	1762	Target Neighborhood Hits	738	Shared Neighborhood Hits	696
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

TOPK_MOUSE
NC score	0.589547 (rank : 793)	θ value	θ > 10 (rank : 1927)
Query Neighborhood Hits	1762	Target Neighborhood Hits	618	Shared Neighborhood Hits	595
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

IRAK3_MOUSE
NC score	0.589214 (rank : 794)	θ value	θ > 10 (rank : 1844)
Query Neighborhood Hits	1762	Target Neighborhood Hits	628	Shared Neighborhood Hits	596
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

RIPK4_HUMAN
NC score	0.587405 (rank : 795)	θ value	0.00228821 (rank : 936)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1094	Shared Neighborhood Hits	795
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

ANKK1_HUMAN
NC score	0.586981 (rank : 796)	θ value	0.000786445 (rank : 898)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1075	Shared Neighborhood Hits	786
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

IRAK3_HUMAN
NC score	0.586922 (rank : 797)	θ value	1.06291 (rank : 1270)
Query Neighborhood Hits	1762	Target Neighborhood Hits	644	Shared Neighborhood Hits	620
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

TOPK_HUMAN
NC score	0.583081 (rank : 798)	θ value	θ > 10 (rank : 1926)
Query Neighborhood Hits	1762	Target Neighborhood Hits	605	Shared Neighborhood Hits	583
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

ACVL1_MOUSE
NC score	0.580454 (rank : 799)	θ value	θ > 10 (rank : 1764)
Query Neighborhood Hits	1762	Target Neighborhood Hits	739	Shared Neighborhood Hits	723
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

BUB1_MOUSE
NC score	0.580203 (rank : 800)	θ value	0.000461057 (rank : 879)
Query Neighborhood Hits	1762	Target Neighborhood Hits	583	Shared Neighborhood Hits	540
SwissProt Accessions	O08901, O09007	Gene names	Bub1
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (MBUB1) (BUB1A).

EPHB6_MOUSE
NC score	0.568353 (rank : 801)	θ value	0.0330416 (rank : 1026)
Query Neighborhood Hits	1762	Target Neighborhood Hits	906	Shared Neighborhood Hits	775
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

ACVL1_HUMAN
NC score	0.560430 (rank : 802)	θ value	θ > 10 (rank : 1763)
Query Neighborhood Hits	1762	Target Neighborhood Hits	716	Shared Neighborhood Hits	698
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

RYK_MOUSE
NC score	0.557178 (rank : 803)	θ value	8.11959e-09 (rank : 639)
Query Neighborhood Hits	1762	Target Neighborhood Hits	715	Shared Neighborhood Hits	688
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

EPHAA_HUMAN
NC score	0.555841 (rank : 804)	θ value	0.00102713 (rank : 908)
Query Neighborhood Hits	1762	Target Neighborhood Hits	960	Shared Neighborhood Hits	784
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHB6_HUMAN
NC score	0.555556 (rank : 805)	θ value	0.00869519 (rank : 979)
Query Neighborhood Hits	1762	Target Neighborhood Hits	912	Shared Neighborhood Hits	753
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

ACV1C_MOUSE
NC score	0.546311 (rank : 806)	θ value	3.0926 (rank : 1447)
Query Neighborhood Hits	1762	Target Neighborhood Hits	715	Shared Neighborhood Hits	690
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

SRPK1_MOUSE
NC score	0.545983 (rank : 807)	θ value	0.00665767 (rank : 976)
Query Neighborhood Hits	1762	Target Neighborhood Hits	639	Shared Neighborhood Hits	567
SwissProt Accessions	O70551, O70193, Q99JT3	Gene names	Srpk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

SRPK2_HUMAN
NC score	0.545755 (rank : 808)	θ value	0.00134147 (rank : 925)
Query Neighborhood Hits	1762	Target Neighborhood Hits	664	Shared Neighborhood Hits	574
SwissProt Accessions	P78362, O75220, O75221, Q6NUL0, Q6V1X2, Q8IYQ3	Gene names	SRPK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

SRPK1_HUMAN
NC score	0.544175 (rank : 809)	θ value	0.00665767 (rank : 975)
Query Neighborhood Hits	1762	Target Neighborhood Hits	706	Shared Neighborhood Hits	584
SwissProt Accessions	Q96SB4, Q12890, Q5R364, Q5R365, Q8IY12	Gene names	SRPK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

STK23_MOUSE
NC score	0.543570 (rank : 810)	θ value	0.00298849 (rank : 948)
Query Neighborhood Hits	1762	Target Neighborhood Hits	572	Shared Neighborhood Hits	557
SwissProt Accessions	Q9Z0G2	Gene names	Stk23, Mssk1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

SRPK2_MOUSE
NC score	0.543187 (rank : 811)	θ value	0.00134147 (rank : 926)
Query Neighborhood Hits	1762	Target Neighborhood Hits	765	Shared Neighborhood Hits	586
SwissProt Accessions	O54781, Q8VCD9	Gene names	Srpk2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

STK23_HUMAN
NC score	0.543037 (rank : 812)	θ value	0.00298849 (rank : 947)
Query Neighborhood Hits	1762	Target Neighborhood Hits	556	Shared Neighborhood Hits	551
SwissProt Accessions	Q9UPE1, Q13583, Q9UM62	Gene names	STK23, MSSK1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

RYK_HUMAN
NC score	0.542817 (rank : 813)	θ value	5.26297e-08 (rank : 676)
Query Neighborhood Hits	1762	Target Neighborhood Hits	701	Shared Neighborhood Hits	677
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

ACV1C_HUMAN
NC score	0.541719 (rank : 814)	θ value	5.27518 (rank : 1541)
Query Neighborhood Hits	1762	Target Neighborhood Hits	709	Shared Neighborhood Hits	684
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

MLKL_HUMAN
NC score	0.531391 (rank : 815)	θ value	θ > 10 (rank : 1856)
Query Neighborhood Hits	1762	Target Neighborhood Hits	600	Shared Neighborhood Hits	564
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

GUC2F_HUMAN
NC score	0.513069 (rank : 816)	θ value	0.000786445 (rank : 900)
Query Neighborhood Hits	1762	Target Neighborhood Hits	740	Shared Neighborhood Hits	665
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

AMHR2_HUMAN
NC score	0.505903 (rank : 817)	θ value	0.21417 (rank : 1120)
Query Neighborhood Hits	1762	Target Neighborhood Hits	715	Shared Neighborhood Hits	655
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

VRK1_MOUSE
NC score	0.493186 (rank : 818)	θ value	4.92598e-06 (rank : 767)
Query Neighborhood Hits	1762	Target Neighborhood Hits	583	Shared Neighborhood Hits	574
SwissProt Accessions	Q80X41, O88635, O88636, Q8C2P7, Q91YH9	Gene names	Vrk1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) (Serine/threonine-protein kinase 51PK).

VRK2_MOUSE
NC score	0.488019 (rank : 819)	θ value	0.0113563 (rank : 997)
Query Neighborhood Hits	1762	Target Neighborhood Hits	586	Shared Neighborhood Hits	573
SwissProt Accessions	Q8BN21, Q5F1Z5, Q5SP88, Q8BPU8, Q8CJ46, Q91WS1, Q9CZF9	Gene names	Vrk2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

VRK1_HUMAN
NC score	0.487707 (rank : 820)	θ value	5.44631e-05 (rank : 832)
Query Neighborhood Hits	1762	Target Neighborhood Hits	584	Shared Neighborhood Hits	573
SwissProt Accessions	Q99986	Gene names	VRK1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1).

VRK2_HUMAN
NC score	0.485646 (rank : 821)	θ value	0.000602161 (rank : 897)
Query Neighborhood Hits	1762	Target Neighborhood Hits	582	Shared Neighborhood Hits	559
SwissProt Accessions	Q86Y07, Q49AK9, Q53EU9, Q86Y08, Q86Y09, Q86Y10, Q86Y11, Q86Y12, Q8IXI5, Q99987	Gene names	VRK2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

NRBP_HUMAN
NC score	0.469125 (rank : 822)	θ value	1.38821 (rank : 1327)
Query Neighborhood Hits	1762	Target Neighborhood Hits	448	Shared Neighborhood Hits	419
SwissProt Accessions	Q9UHY1, Q53FZ5, Q96SU3	Gene names	NRBP1, BCON3, NRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein.

TEX14_MOUSE
NC score	0.468703 (rank : 823)	θ value	θ > 10 (rank : 1925)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1333	Shared Neighborhood Hits	674
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

NRBP_MOUSE
NC score	0.467643 (rank : 824)	θ value	0.365318 (rank : 1160)
Query Neighborhood Hits	1762	Target Neighborhood Hits	442	Shared Neighborhood Hits	414
SwissProt Accessions	Q99J45, Q8BL77	Gene names	Nrbp1, Madm, Nrbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein (MLF1 adapter molecule) (HLS7- interacting protein kinase).

GUC2D_HUMAN
NC score	0.466170 (rank : 825)	θ value	0.0193708 (rank : 1006)
Query Neighborhood Hits	1762	Target Neighborhood Hits	715	Shared Neighborhood Hits	653
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2C_HUMAN
NC score	0.459439 (rank : 826)	θ value	3.0926 (rank : 1462)
Query Neighborhood Hits	1762	Target Neighborhood Hits	624	Shared Neighborhood Hits	571
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GUC2G_MOUSE
NC score	0.445258 (rank : 827)	θ value	0.00869519 (rank : 981)
Query Neighborhood Hits	1762	Target Neighborhood Hits	644	Shared Neighborhood Hits	571
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

GUC2E_MOUSE
NC score	0.443798 (rank : 828)	θ value	0.0431538 (rank : 1043)
Query Neighborhood Hits	1762	Target Neighborhood Hits	692	Shared Neighborhood Hits	626
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

ANPRB_HUMAN
NC score	0.443502 (rank : 829)	θ value	θ > 10 (rank : 1768)
Query Neighborhood Hits	1762	Target Neighborhood Hits	646	Shared Neighborhood Hits	572
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

TEX14_HUMAN
NC score	0.429028 (rank : 830)	θ value	θ > 10 (rank : 1924)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1103	Shared Neighborhood Hits	614
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

OBSL1_HUMAN
NC score	0.421978 (rank : 831)	θ value	2.34062e-40 (rank : 19)
Query Neighborhood Hits	1762	Target Neighborhood Hits	354	Shared Neighborhood Hits	270
SwissProt Accessions	O75147, Q96IW3	Gene names	OBSL1, KIAA0657
Domain Architecture	No domain graphic available
Description	Obscurin-like protein 1 precursor.

ANPRB_MOUSE
NC score	0.416795 (rank : 832)	θ value	θ > 10 (rank : 1769)
Query Neighborhood Hits	1762	Target Neighborhood Hits	607	Shared Neighborhood Hits	546
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRA_HUMAN
NC score	0.413776 (rank : 833)	θ value	θ > 10 (rank : 1766)
Query Neighborhood Hits	1762	Target Neighborhood Hits	612	Shared Neighborhood Hits	534
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
NC score	0.413290 (rank : 834)	θ value	θ > 10 (rank : 1767)
Query Neighborhood Hits	1762	Target Neighborhood Hits	600	Shared Neighborhood Hits	526
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ILK1_HUMAN
NC score	0.410724 (rank : 835)	θ value	θ > 10 (rank : 1839)
Query Neighborhood Hits	1762	Target Neighborhood Hits	857	Shared Neighborhood Hits	585
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK_MOUSE
NC score	0.408587 (rank : 836)	θ value	θ > 10 (rank : 1841)
Query Neighborhood Hits	1762	Target Neighborhood Hits	858	Shared Neighborhood Hits	586
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ROBO1_MOUSE
NC score	0.406209 (rank : 837)	θ value	5.97985e-28 (rank : 52)
Query Neighborhood Hits	1762	Target Neighborhood Hits	559	Shared Neighborhood Hits	353
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

ROBO1_HUMAN
NC score	0.406174 (rank : 838)	θ value	2.68423e-28 (rank : 48)
Query Neighborhood Hits	1762	Target Neighborhood Hits	529	Shared Neighborhood Hits	332
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

BUB1_HUMAN
NC score	0.405996 (rank : 839)	θ value	0.0563607 (rank : 1053)
Query Neighborhood Hits	1762	Target Neighborhood Hits	543	Shared Neighborhood Hits	417
SwissProt Accessions	O43683, O43430, O43643, O60626	Gene names	BUB1, BUB1L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (hBUB1) (BUB1A).

ROBO3_HUMAN
NC score	0.405148 (rank : 840)	θ value	8.08199e-25 (rank : 76)
Query Neighborhood Hits	1762	Target Neighborhood Hits	570	Shared Neighborhood Hits	375
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

MYPN_HUMAN
NC score	0.404430 (rank : 841)	θ value	4.43474e-23 (rank : 100)
Query Neighborhood Hits	1762	Target Neighborhood Hits	418	Shared Neighborhood Hits	308
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

ROBO2_HUMAN
NC score	0.404414 (rank : 842)	θ value	7.54701e-31 (rank : 35)
Query Neighborhood Hits	1762	Target Neighborhood Hits	479	Shared Neighborhood Hits	323
SwissProt Accessions	Q9HCK4, O43608	Gene names	ROBO2, KIAA1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

ROBO2_MOUSE
NC score	0.404279 (rank : 843)	θ value	4.42448e-31 (rank : 33)
Query Neighborhood Hits	1762	Target Neighborhood Hits	504	Shared Neighborhood Hits	331
SwissProt Accessions	Q7TPD3, Q8BJ59	Gene names	Robo2, Kiaa1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

ROBO3_MOUSE
NC score	0.401808 (rank : 844)	θ value	1.5773e-20 (rank : 161)
Query Neighborhood Hits	1762	Target Neighborhood Hits	524	Shared Neighborhood Hits	360
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

MYPN_MOUSE
NC score	0.401698 (rank : 845)	θ value	4.43474e-23 (rank : 101)
Query Neighborhood Hits	1762	Target Neighborhood Hits	421	Shared Neighborhood Hits	310
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

PUNC_HUMAN
NC score	0.399457 (rank : 846)	θ value	9.24701e-21 (rank : 156)
Query Neighborhood Hits	1762	Target Neighborhood Hits	449	Shared Neighborhood Hits	302
SwissProt Accessions	Q8IVU1, O95215	Gene names	PUNC
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

PUNC_MOUSE
NC score	0.399405 (rank : 847)	θ value	1.02238e-19 (rank : 175)
Query Neighborhood Hits	1762	Target Neighborhood Hits	501	Shared Neighborhood Hits	325
SwissProt Accessions	Q8BQC3, O70246, Q792T2, Q9Z2S6	Gene names	Punc
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

ILK2_HUMAN
NC score	0.398366 (rank : 848)	θ value	θ > 10 (rank : 1840)
Query Neighborhood Hits	1762	Target Neighborhood Hits	848	Shared Neighborhood Hits	579
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

MYOTI_HUMAN
NC score	0.397300 (rank : 849)	θ value	8.38298e-14 (rank : 443)
Query Neighborhood Hits	1762	Target Neighborhood Hits	292	Shared Neighborhood Hits	261
SwissProt Accessions	Q9UBF9	Gene names	MYOT, TTID
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein) (57 kDa cytoskeletal protein).

MYOTI_MOUSE
NC score	0.396167 (rank : 850)	θ value	7.58209e-15 (rank : 386)
Query Neighborhood Hits	1762	Target Neighborhood Hits	297	Shared Neighborhood Hits	257
SwissProt Accessions	Q9JIF9	Gene names	Myot, Ttid
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein).

BOC_MOUSE
NC score	0.394622 (rank : 851)	θ value	5.99374e-20 (rank : 171)
Query Neighborhood Hits	1762	Target Neighborhood Hits	433	Shared Neighborhood Hits	312
SwissProt Accessions	Q6AZB0, Q6KAM5, Q6P5H3, Q7TMJ3, Q8CE73, Q8CE91, Q8R377, Q923W7	Gene names	Boc
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

DSCL1_HUMAN
NC score	0.393912 (rank : 852)	θ value	1.02238e-19 (rank : 172)
Query Neighborhood Hits	1762	Target Neighborhood Hits	589	Shared Neighborhood Hits	379
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

DCC_HUMAN
NC score	0.392243 (rank : 853)	θ value	2.12685e-25 (rank : 69)
Query Neighborhood Hits	1762	Target Neighborhood Hits	583	Shared Neighborhood Hits	370
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

BOC_HUMAN
NC score	0.392174 (rank : 854)	θ value	2.13179e-17 (rank : 247)
Query Neighborhood Hits	1762	Target Neighborhood Hits	543	Shared Neighborhood Hits	339
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

NFASC_MOUSE
NC score	0.391841 (rank : 855)	θ value	1.74391e-19 (rank : 178)
Query Neighborhood Hits	1762	Target Neighborhood Hits	475	Shared Neighborhood Hits	339
SwissProt Accessions	Q810U3	Gene names	Nfasc
Domain Architecture
Description	Neurofascin precursor.

DCC_MOUSE
NC score	0.391344 (rank : 856)	θ value	2.12685e-25 (rank : 70)
Query Neighborhood Hits	1762	Target Neighborhood Hits	896	Shared Neighborhood Hits	473
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

DSCAM_HUMAN
NC score	0.391323 (rank : 857)	θ value	8.65492e-19 (rank : 194)
Query Neighborhood Hits	1762	Target Neighborhood Hits	524	Shared Neighborhood Hits	342
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).

NCAM2_MOUSE
NC score	0.390942 (rank : 858)	θ value	2.35696e-16 (rank : 317)
Query Neighborhood Hits	1762	Target Neighborhood Hits	472	Shared Neighborhood Hits	324
SwissProt Accessions	O35136, O35962	Gene names	Ncam2, Ocam, Rncam
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2) (RB-8 neural cell adhesion molecule) (R4B12).

NEO1_HUMAN
NC score	0.390758 (rank : 859)	θ value	5.79196e-23 (rank : 104)
Query Neighborhood Hits	1762	Target Neighborhood Hits	530	Shared Neighborhood Hits	340
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

NFASC_HUMAN
NC score	0.390296 (rank : 860)	θ value	3.51386e-20 (rank : 169)
Query Neighborhood Hits	1762	Target Neighborhood Hits	497	Shared Neighborhood Hits	349
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

NEO1_MOUSE
NC score	0.390063 (rank : 861)	θ value	6.40375e-22 (rank : 125)
Query Neighborhood Hits	1762	Target Neighborhood Hits	523	Shared Neighborhood Hits	343
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

CNTN5_HUMAN
NC score	0.390011 (rank : 862)	θ value	3.39556e-23 (rank : 97)
Query Neighborhood Hits	1762	Target Neighborhood Hits	446	Shared Neighborhood Hits	329
SwissProt Accessions	O94779, O94780	Gene names	CNTN5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2) (hNB-2).

FGRL1_HUMAN
NC score	0.389518 (rank : 863)	θ value	7.58209e-15 (rank : 385)
Query Neighborhood Hits	1762	Target Neighborhood Hits	335	Shared Neighborhood Hits	267
SwissProt Accessions	Q8N441, Q6PJN1, Q9BXN7, Q9H4D7	Gene names	FGFRL1, FGFR5, FHFR
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5) (FGFR-like protein) (FGF homologous factor receptor).

NCAM2_HUMAN
NC score	0.389379 (rank : 864)	θ value	1.68911e-14 (rank : 416)
Query Neighborhood Hits	1762	Target Neighborhood Hits	441	Shared Neighborhood Hits	319
SwissProt Accessions	O15394	Gene names	NCAM2, NCAM21
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2).

FGRL1_MOUSE
NC score	0.388615 (rank : 865)	θ value	9.90251e-15 (rank : 390)
Query Neighborhood Hits	1762	Target Neighborhood Hits	325	Shared Neighborhood Hits	271
SwissProt Accessions	Q91V87, Q920C2, Q920C3	Gene names	Fgfrl1, Fgfr5
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5).

CNTN4_MOUSE
NC score	0.388345 (rank : 866)	θ value	9.54697e-26 (rank : 65)
Query Neighborhood Hits	1762	Target Neighborhood Hits	445	Shared Neighborhood Hits	312
SwissProt Accessions	Q69Z26, Q8BRT6, Q8CBD3	Gene names	Cntn4, Kiaa3024
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

CNTN4_HUMAN
NC score	0.387774 (rank : 867)	θ value	1.12775e-26 (rank : 59)
Query Neighborhood Hits	1762	Target Neighborhood Hits	449	Shared Neighborhood Hits	313
SwissProt Accessions	Q8IWV2, Q8IX14, Q8TC35	Gene names	CNTN4
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

NCA11_MOUSE
NC score	0.386774 (rank : 868)	θ value	5.43371e-13 (rank : 477)
Query Neighborhood Hits	1762	Target Neighborhood Hits	661	Shared Neighborhood Hits	426
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

CNTN5_MOUSE
NC score	0.386478 (rank : 869)	θ value	4.9032e-22 (rank : 123)
Query Neighborhood Hits	1762	Target Neighborhood Hits	434	Shared Neighborhood Hits	326
SwissProt Accessions	P68500	Gene names	Cntn5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2).

CDON_HUMAN
NC score	0.386268 (rank : 870)	θ value	1.33837e-11 (rank : 531)
Query Neighborhood Hits	1762	Target Neighborhood Hits	412	Shared Neighborhood Hits	295
SwissProt Accessions	Q4KMG0, O14631	Gene names	CDON, CDO
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

L1CAM_HUMAN
NC score	0.385447 (rank : 871)	θ value	7.0802e-21 (rank : 152)
Query Neighborhood Hits	1762	Target Neighborhood Hits	457	Shared Neighborhood Hits	324
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

NCA12_HUMAN
NC score	0.385372 (rank : 872)	θ value	1.42992e-13 (rank : 451)
Query Neighborhood Hits	1762	Target Neighborhood Hits	437	Shared Neighborhood Hits	315
SwissProt Accessions	P13592, P13593	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120) (CD56 antigen).

CNTN2_HUMAN
NC score	0.385354 (rank : 873)	θ value	1.24977e-17 (rank : 242)
Query Neighborhood Hits	1762	Target Neighborhood Hits	440	Shared Neighborhood Hits	326
SwissProt Accessions	Q02246, P78432	Gene names	CNTN2, TAG1, TAX1
Domain Architecture
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CNTN2_MOUSE
NC score	0.384917 (rank : 874)	θ value	1.38178e-16 (rank : 293)
Query Neighborhood Hits	1762	Target Neighborhood Hits	450	Shared Neighborhood Hits	331
SwissProt Accessions	Q61330, Q6NZJ4, Q7TSJ5	Gene names	Cntn2, Tax
Domain Architecture	No domain graphic available
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CDON_MOUSE
NC score	0.384800 (rank : 875)	θ value	1.9326e-10 (rank : 566)
Query Neighborhood Hits	1762	Target Neighborhood Hits	410	Shared Neighborhood Hits	302
SwissProt Accessions	Q32MD9, O88971	Gene names	Cdon, Cdo
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

NCA11_HUMAN
NC score	0.384761 (rank : 876)	θ value	9.90251e-15 (rank : 394)
Query Neighborhood Hits	1762	Target Neighborhood Hits	443	Shared Neighborhood Hits	317
SwissProt Accessions	P13591, Q15829, Q16180	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM 140) (NCAM-140) (CD56 antigen).

L1CAM_MOUSE
NC score	0.384075 (rank : 877)	θ value	2.06002e-20 (rank : 163)
Query Neighborhood Hits	1762	Target Neighborhood Hits	457	Shared Neighborhood Hits	322
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

CNTN6_MOUSE
NC score	0.384021 (rank : 878)	θ value	2.87452e-22 (rank : 120)
Query Neighborhood Hits	1762	Target Neighborhood Hits	429	Shared Neighborhood Hits	307
SwissProt Accessions	Q9JMB8, Q8C6X1	Gene names	Cntn6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (mNB-3).

CNTN3_HUMAN
NC score	0.383941 (rank : 879)	θ value	7.56453e-23 (rank : 107)
Query Neighborhood Hits	1762	Target Neighborhood Hits	455	Shared Neighborhood Hits	322
SwissProt Accessions	Q9P232, Q9H039	Gene names	CNTN3, KIAA1496, PANG
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

CNTN6_HUMAN
NC score	0.382200 (rank : 880)	θ value	4.15078e-21 (rank : 142)
Query Neighborhood Hits	1762	Target Neighborhood Hits	422	Shared Neighborhood Hits	307
SwissProt Accessions	Q9UQ52	Gene names	CNTN6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (hNB-3).

NCA12_MOUSE
NC score	0.382073 (rank : 881)	θ value	1.2105e-12 (rank : 495)
Query Neighborhood Hits	1762	Target Neighborhood Hits	399	Shared Neighborhood Hits	302
SwissProt Accessions	P13594, Q61950	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120).

NRCAM_MOUSE
NC score	0.381883 (rank : 882)	θ value	1.92812e-18 (rank : 209)
Query Neighborhood Hits	1762	Target Neighborhood Hits	432	Shared Neighborhood Hits	321
SwissProt Accessions	Q810U4, Q80U33, Q8BLG8, Q8BX92, Q8BYJ8	Gene names	Nrcam, Kiaa0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (mBravo).

CNTN1_MOUSE
NC score	0.381557 (rank : 883)	θ value	3.51386e-20 (rank : 166)
Query Neighborhood Hits	1762	Target Neighborhood Hits	422	Shared Neighborhood Hits	312
SwissProt Accessions	P12960, Q6NXV7, Q8BR42, Q8C6A0	Gene names	Cntn1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3).

CNTN3_MOUSE
NC score	0.381086 (rank : 884)	θ value	6.84181e-24 (rank : 85)
Query Neighborhood Hits	1762	Target Neighborhood Hits	447	Shared Neighborhood Hits	317
SwissProt Accessions	Q07409	Gene names	Cntn3, Pang, Pcs
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

CNTN1_HUMAN
NC score	0.380997 (rank : 885)	θ value	2.27762e-19 (rank : 181)
Query Neighborhood Hits	1762	Target Neighborhood Hits	431	Shared Neighborhood Hits	314
SwissProt Accessions	Q12860, Q12861, Q14030, Q8N466	Gene names	CNTN1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3) (Glycoprotein gp135).

SDK1_HUMAN
NC score	0.378722 (rank : 886)	θ value	8.95645e-16 (rank : 343)
Query Neighborhood Hits	1762	Target Neighborhood Hits	511	Shared Neighborhood Hits	352
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

NRCAM_HUMAN
NC score	0.378637 (rank : 887)	θ value	1.80466e-16 (rank : 309)
Query Neighborhood Hits	1762	Target Neighborhood Hits	439	Shared Neighborhood Hits	326
SwissProt Accessions	Q92823, O15051, O15179, Q9UHI3, Q9UHI4	Gene names	NRCAM, KIAA0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (hBravo).

SDK1_MOUSE
NC score	0.376595 (rank : 888)	θ value	1.52774e-15 (rank : 357)
Query Neighborhood Hits	1762	Target Neighborhood Hits	495	Shared Neighborhood Hits	339
SwissProt Accessions	Q3UH53, Q3UFD1, Q6PAL2, Q6V3A4, Q8BMC2, Q8BZI1	Gene names	Sdk1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

SDK2_HUMAN
NC score	0.374787 (rank : 889)	θ value	2.35696e-16 (rank : 318)
Query Neighborhood Hits	1762	Target Neighborhood Hits	495	Shared Neighborhood Hits	338
SwissProt Accessions	Q58EX2, Q86VY3, Q9NTD2, Q9NVB3, Q9P214	Gene names	SDK2, KIAA1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

SDK2_MOUSE
NC score	0.373991 (rank : 890)	θ value	4.02038e-16 (rank : 331)
Query Neighborhood Hits	1762	Target Neighborhood Hits	480	Shared Neighborhood Hits	340
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

CHL1_HUMAN
NC score	0.373312 (rank : 891)	θ value	7.34386e-10 (rank : 586)
Query Neighborhood Hits	1762	Target Neighborhood Hits	413	Shared Neighborhood Hits	311
SwissProt Accessions	O00533, Q2M3G2, Q59FY0	Gene names	CHL1, CALL
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Close homolog of L1).

CHL1_MOUSE
NC score	0.373186 (rank : 892)	θ value	1.133e-10 (rank : 559)
Query Neighborhood Hits	1762	Target Neighborhood Hits	402	Shared Neighborhood Hits	303
SwissProt Accessions	P70232, Q8BS24, Q8C6W0, Q8C823, Q8VBY7	Gene names	Chl1, Call
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Cell adhesion molecule with homology to L1CAM) (Close homolog of L1) (Chl1-like protein).

LSAMP_HUMAN
NC score	0.366171 (rank : 893)	θ value	1.29331e-14 (rank : 400)
Query Neighborhood Hits	1762	Target Neighborhood Hits	347	Shared Neighborhood Hits	273
SwissProt Accessions	Q13449, Q8IV49	Gene names	LSAMP, LAMP
Domain Architecture
Description	Limbic system-associated membrane protein precursor (LSAMP).

PI3R4_MOUSE
NC score	0.366106 (rank : 894)	θ value	0.0961366 (rank : 1080)
Query Neighborhood Hits	1762	Target Neighborhood Hits	535	Shared Neighborhood Hits	360
SwissProt Accessions	Q8VD65, Q56A65, Q8C948, Q8C9D7, Q9CVC5	Gene names	Pik3r4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4).

LSAMP_MOUSE
NC score	0.365988 (rank : 895)	θ value	2.20605e-14 (rank : 421)
Query Neighborhood Hits	1762	Target Neighborhood Hits	344	Shared Neighborhood Hits	272
SwissProt Accessions	Q8BLK3	Gene names	Lsamp
Domain Architecture	No domain graphic available
Description	Limbic system-associated membrane protein precursor (LSAMP).

MYPC1_HUMAN
NC score	0.363451 (rank : 896)	θ value	2.69047e-20 (rank : 164)
Query Neighborhood Hits	1762	Target Neighborhood Hits	303	Shared Neighborhood Hits	259
SwissProt Accessions	Q00872, Q15497	Gene names	MYBPC1, MYBPCS
Domain Architecture
Description	Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform).

OPCM_HUMAN
NC score	0.362215 (rank : 897)	θ value	2.98157e-11 (rank : 540)
Query Neighborhood Hits	1762	Target Neighborhood Hits	332	Shared Neighborhood Hits	271
SwissProt Accessions	Q14982	Gene names	OPCML, OBCAM
Domain Architecture
Description	Opioid-binding protein/cell adhesion molecule precursor (OBCAM) (Opioid-binding cell adhesion molecule) (OPCML).

ROBO4_MOUSE
NC score	0.358741 (rank : 898)	θ value	3.77169e-06 (rank : 759)
Query Neighborhood Hits	1762	Target Neighborhood Hits	358	Shared Neighborhood Hits	271
SwissProt Accessions	Q8C310, Q9DBW1	Gene names	Robo4
Domain Architecture
Description	Roundabout homolog 4 precursor.

MYPC2_HUMAN
NC score	0.356251 (rank : 899)	θ value	1.33526e-19 (rank : 177)
Query Neighborhood Hits	1762	Target Neighborhood Hits	316	Shared Neighborhood Hits	264
SwissProt Accessions	Q14324	Gene names	MYBPC2, MYBPCF
Domain Architecture
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

ROBO4_HUMAN
NC score	0.355185 (rank : 900)	θ value	4.92598e-06 (rank : 766)
Query Neighborhood Hits	1762	Target Neighborhood Hits	364	Shared Neighborhood Hits	284
SwissProt Accessions	Q8WZ75, Q8TEG1, Q96JV6, Q9H718, Q9NWJ8	Gene names	ROBO4
Domain Architecture
Description	Roundabout homolog 4 precursor (Magic roundabout).

NTRI_MOUSE
NC score	0.354862 (rank : 901)	θ value	4.0297e-08 (rank : 668)
Query Neighborhood Hits	1762	Target Neighborhood Hits	342	Shared Neighborhood Hits	271
SwissProt Accessions	Q99PJ0	Gene names	Nt, Hnt
Domain Architecture
Description	Neurotrimin precursor.

NEGR1_HUMAN
NC score	0.354098 (rank : 902)	θ value	6.87365e-08 (rank : 680)
Query Neighborhood Hits	1762	Target Neighborhood Hits	346	Shared Neighborhood Hits	260
SwissProt Accessions	Q7Z3B1, Q5VT21, Q6UY06, Q8NAQ3	Gene names	NEGR1
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor.

NTRI_HUMAN
NC score	0.353975 (rank : 903)	θ value	4.0297e-08 (rank : 667)
Query Neighborhood Hits	1762	Target Neighborhood Hits	344	Shared Neighborhood Hits	271
SwissProt Accessions	Q9P121, Q6UXJ3, Q86VJ9	Gene names	NT
Domain Architecture
Description	Neurotrimin precursor (hNT).

NEGR1_MOUSE
NC score	0.353654 (rank : 904)	θ value	6.21693e-09 (rank : 630)
Query Neighborhood Hits	1762	Target Neighborhood Hits	349	Shared Neighborhood Hits	261
SwissProt Accessions	Q80Z24, Q3UHQ8, Q80T70	Gene names	Negr1, Kiaa3001, Ntra
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor (Kilon protein) (Kindred of IgLON) (Neurotractin).

MYOM2_HUMAN
NC score	0.352608 (rank : 905)	θ value	3.52202e-12 (rank : 504)
Query Neighborhood Hits	1762	Target Neighborhood Hits	341	Shared Neighborhood Hits	267
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

PI3R4_HUMAN
NC score	0.351690 (rank : 906)	θ value	0.0961366 (rank : 1079)
Query Neighborhood Hits	1762	Target Neighborhood Hits	534	Shared Neighborhood Hits	349
SwissProt Accessions	Q99570	Gene names	PIK3R4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein).

MYPC2_MOUSE
NC score	0.351070 (rank : 907)	θ value	1.38178e-16 (rank : 295)
Query Neighborhood Hits	1762	Target Neighborhood Hits	297	Shared Neighborhood Hits	252
SwissProt Accessions	Q5XKE0, Q8C109, Q8K2V0	Gene names	Mybpc2
Domain Architecture	No domain graphic available
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

MAMC1_HUMAN
NC score	0.350066 (rank : 908)	θ value	6.87365e-08 (rank : 678)
Query Neighborhood Hits	1762	Target Neighborhood Hits	357	Shared Neighborhood Hits	269
SwissProt Accessions	Q7Z553	Gene names	MAMDC1, MDGA2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

MYPC3_MOUSE
NC score	0.349650 (rank : 909)	θ value	5.60996e-18 (rank : 224)
Query Neighborhood Hits	1762	Target Neighborhood Hits	310	Shared Neighborhood Hits	260
SwissProt Accessions	O70468, O88997	Gene names	Mybpc3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

MAMC1_MOUSE
NC score	0.349424 (rank : 910)	θ value	1.17247e-07 (rank : 696)
Query Neighborhood Hits	1762	Target Neighborhood Hits	357	Shared Neighborhood Hits	269
SwissProt Accessions	P60755	Gene names	Mamdc1, Mdga2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

MYOM1_MOUSE
NC score	0.349224 (rank : 911)	θ value	1.02475e-11 (rank : 528)
Query Neighborhood Hits	1762	Target Neighborhood Hits	415	Shared Neighborhood Hits	299
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

STK31_HUMAN
NC score	0.349142 (rank : 912)	θ value	0.279714 (rank : 1149)
Query Neighborhood Hits	1762	Target Neighborhood Hits	570	Shared Neighborhood Hits	377
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

MDGA1_HUMAN
NC score	0.348158 (rank : 913)	θ value	2.98157e-11 (rank : 539)
Query Neighborhood Hits	1762	Target Neighborhood Hits	358	Shared Neighborhood Hits	265
SwissProt Accessions	Q8NFP4, Q8NBE3	Gene names	MDGA1, MAMDC3
Domain Architecture
Description	MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor (MAM domain-containing protein 3) (GPI and MAM protein) (Glycosylphosphatidylinositol-MAM) (GPIM).

MYPC3_HUMAN
NC score	0.347135 (rank : 914)	θ value	9.90251e-15 (rank : 393)
Query Neighborhood Hits	1762	Target Neighborhood Hits	318	Shared Neighborhood Hits	265
SwissProt Accessions	Q14896, Q16410, Q6R2F7, Q9UE27, Q9UM53	Gene names	MYBPC3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

MYOM1_HUMAN
NC score	0.342474 (rank : 915)	θ value	5.62301e-10 (rank : 585)
Query Neighborhood Hits	1762	Target Neighborhood Hits	405	Shared Neighborhood Hits	283
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

NTKL_MOUSE
NC score	0.339433 (rank : 916)	θ value	5.27518 (rank : 1577)
Query Neighborhood Hits	1762	Target Neighborhood Hits	326	Shared Neighborhood Hits	292
SwissProt Accessions	Q9EQC5, Q3TST7, Q3UKU0, Q8K222	Gene names	Scyl1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (105 kDa kinase- like protein) (Mitosis-associated kinase-like protein NTKL).

VCAM1_MOUSE
NC score	0.339383 (rank : 917)	θ value	8.97725e-08 (rank : 690)
Query Neighborhood Hits	1762	Target Neighborhood Hits	320	Shared Neighborhood Hits	246
SwissProt Accessions	P29533	Gene names	Vcam1, Vcam-1
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1).

NPHN_HUMAN
NC score	0.339233 (rank : 918)	θ value	5.81887e-07 (rank : 731)
Query Neighborhood Hits	1762	Target Neighborhood Hits	362	Shared Neighborhood Hits	265
SwissProt Accessions	O60500	Gene names	NPHS1, NPHN
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

VCAM1_HUMAN
NC score	0.337130 (rank : 919)	θ value	5.81887e-07 (rank : 736)
Query Neighborhood Hits	1762	Target Neighborhood Hits	352	Shared Neighborhood Hits	245
SwissProt Accessions	P19320, Q6NUP8	Gene names	VCAM1, L1CAM
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1) (CD106 antigen) (INCAM-100).

NPHN_MOUSE
NC score	0.332016 (rank : 920)	θ value	5.81887e-07 (rank : 732)
Query Neighborhood Hits	1762	Target Neighborhood Hits	370	Shared Neighborhood Hits	265
SwissProt Accessions	Q9QZS7	Gene names	Nphs1, Nphn
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

K2002_HUMAN
NC score	0.331014 (rank : 921)	θ value	0.0252991 (rank : 1017)
Query Neighborhood Hits	1762	Target Neighborhood Hits	274	Shared Neighborhood Hits	262
SwissProt Accessions	Q9H792, Q6ZS78, Q8NCM3	Gene names	KIAA2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

MAG_MOUSE
NC score	0.329118 (rank : 922)	θ value	7.1131e-05 (rank : 836)
Query Neighborhood Hits	1762	Target Neighborhood Hits	271	Shared Neighborhood Hits	238
SwissProt Accessions	P20917, P16880	Gene names	Mag
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

MAG_HUMAN
NC score	0.328422 (rank : 923)	θ value	0.000121331 (rank : 854)
Query Neighborhood Hits	1762	Target Neighborhood Hits	278	Shared Neighborhood Hits	239
SwissProt Accessions	P20916	Gene names	MAG
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

MYBPH_HUMAN
NC score	0.328124 (rank : 924)	θ value	3.64472e-09 (rank : 619)
Query Neighborhood Hits	1762	Target Neighborhood Hits	256	Shared Neighborhood Hits	240
SwissProt Accessions	Q13203, Q16886, Q86YC5	Gene names	MYBPH
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

MYBPH_MOUSE
NC score	0.326718 (rank : 925)	θ value	7.34386e-10 (rank : 588)
Query Neighborhood Hits	1762	Target Neighborhood Hits	290	Shared Neighborhood Hits	247
SwissProt Accessions	P70402	Gene names	Mybph
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

SN_MOUSE
NC score	0.322935 (rank : 926)	θ value	1.25267e-09 (rank : 596)
Query Neighborhood Hits	1762	Target Neighborhood Hits	416	Shared Neighborhood Hits	275
SwissProt Accessions	Q62230, O55216, Q62228, Q62229	Gene names	Sn, Sa
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (Sheep erythrocyte receptor) (SER) (CD169 antigen).

SN_HUMAN
NC score	0.319160 (rank : 927)	θ value	2.79066e-09 (rank : 610)
Query Neighborhood Hits	1762	Target Neighborhood Hits	434	Shared Neighborhood Hits	269
SwissProt Accessions	Q9BZZ2, Q96DL4, Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7	Gene names	SN
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (CD169 antigen).

RN5A_MOUSE
NC score	0.316307 (rank : 928)	θ value	0.365318 (rank : 1163)
Query Neighborhood Hits	1762	Target Neighborhood Hits	899	Shared Neighborhood Hits	612
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

RAGE_HUMAN
NC score	0.316283 (rank : 929)	θ value	3.19293e-05 (rank : 816)
Query Neighborhood Hits	1762	Target Neighborhood Hits	269	Shared Neighborhood Hits	227
SwissProt Accessions	Q15109, Q15279, Q9H2X7, Q9Y3R3	Gene names	AGER, RAGE
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

KIRR2_HUMAN
NC score	0.314062 (rank : 930)	θ value	1.17247e-07 (rank : 695)
Query Neighborhood Hits	1762	Target Neighborhood Hits	321	Shared Neighborhood Hits	236
SwissProt Accessions	Q6UWL6, Q6P1R1, Q7Z5P1, Q7Z5P2, Q96IQ8, Q9H0T1	Gene names	KIRREL2, NEPH3
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3).

TMIGD_HUMAN
NC score	0.313136 (rank : 931)	θ value	0.0330416 (rank : 1038)
Query Neighborhood Hits	1762	Target Neighborhood Hits	240	Shared Neighborhood Hits	210
SwissProt Accessions	Q6UXZ0, Q6ZMC6	Gene names	TMIGD
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

FSTL4_HUMAN
NC score	0.312156 (rank : 932)	θ value	4.1701e-05 (rank : 820)
Query Neighborhood Hits	1762	Target Neighborhood Hits	344	Shared Neighborhood Hits	264
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

LU_HUMAN
NC score	0.312120 (rank : 933)	θ value	0.00390308 (rank : 955)
Query Neighborhood Hits	1762	Target Neighborhood Hits	283	Shared Neighborhood Hits	233
SwissProt Accessions	P50895, Q86VC7	Gene names	BCAM, LU, MSK19
Domain Architecture
Description	Lutheran blood group glycoprotein precursor (B-CAM cell surface glycoprotein) (Auberger B antigen) (F8/G253 antigen) (CD239 antigen).

CD22_HUMAN
NC score	0.310795 (rank : 934)	θ value	4.76016e-09 (rank : 621)
Query Neighborhood Hits	1762	Target Neighborhood Hits	365	Shared Neighborhood Hits	241
SwissProt Accessions	P20273, O95699, O95701, O95702, O95703, Q01665, Q92872, Q92873, Q9UQA6, Q9UQA7, Q9UQA8, Q9UQA9, Q9UQB0, Q9Y2A6	Gene names	CD22
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

CD22_MOUSE
NC score	0.310573 (rank : 935)	θ value	2.13673e-09 (rank : 600)
Query Neighborhood Hits	1762	Target Neighborhood Hits	331	Shared Neighborhood Hits	226
SwissProt Accessions	P35329, Q9JHL2, Q9JJX9, Q9JJY0, Q9JJY1, Q9R056, Q9R094, Q9WU51	Gene names	Cd22, Lyb-8
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

FSTL5_HUMAN
NC score	0.307796 (rank : 936)	θ value	0.000602161 (rank : 895)
Query Neighborhood Hits	1762	Target Neighborhood Hits	347	Shared Neighborhood Hits	258
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

TMIGD_MOUSE
NC score	0.307135 (rank : 937)	θ value	0.000786445 (rank : 904)
Query Neighborhood Hits	1762	Target Neighborhood Hits	234	Shared Neighborhood Hits	212
SwissProt Accessions	Q9D7L8, Q8R202	Gene names	Tmigd
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

KIRR2_MOUSE
NC score	0.307128 (rank : 938)	θ value	0.000121331 (rank : 852)
Query Neighborhood Hits	1762	Target Neighborhood Hits	326	Shared Neighborhood Hits	237
SwissProt Accessions	Q7TSU7, Q7TQ98	Gene names	Kirrel2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2).

FSTL4_MOUSE
NC score	0.306879 (rank : 939)	θ value	0.00020696 (rank : 866)
Query Neighborhood Hits	1762	Target Neighborhood Hits	333	Shared Neighborhood Hits	255
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

RAGE_MOUSE
NC score	0.306865 (rank : 940)	θ value	4.92598e-06 (rank : 765)
Query Neighborhood Hits	1762	Target Neighborhood Hits	295	Shared Neighborhood Hits	218
SwissProt Accessions	Q62151	Gene names	Ager, Rage
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

MALT1_HUMAN
NC score	0.305472 (rank : 941)	θ value	0.125558 (rank : 1095)
Query Neighborhood Hits	1762	Target Neighborhood Hits	236	Shared Neighborhood Hits	207
SwissProt Accessions	Q9UDY8, Q9NTB7, Q9ULX4	Gene names	MALT1, MLT
Domain Architecture
Description	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase).

FSTL5_MOUSE
NC score	0.302999 (rank : 942)	θ value	0.00035302 (rank : 877)
Query Neighborhood Hits	1762	Target Neighborhood Hits	355	Shared Neighborhood Hits	255
SwissProt Accessions	Q8BFR2, Q80TG3, Q8C4T3	Gene names	Fstl5, Kiaa1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5) (m- D/Bsp120I 1-2).

ICAM5_MOUSE
NC score	0.297582 (rank : 943)	θ value	1.09739e-05 (rank : 781)
Query Neighborhood Hits	1762	Target Neighborhood Hits	308	Shared Neighborhood Hits	234
SwissProt Accessions	Q60625	Gene names	Icam5, Tlcn
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

NPTN_HUMAN
NC score	0.296349 (rank : 944)	θ value	0.00869519 (rank : 985)
Query Neighborhood Hits	1762	Target Neighborhood Hits	212	Shared Neighborhood Hits	193
SwissProt Accessions	Q9Y639, Q59EJ9, Q6NVX7, Q9Y640	Gene names	NPTN, SDFR1, SDR1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

STK31_MOUSE
NC score	0.295539 (rank : 945)	θ value	0.813845 (rank : 1248)
Query Neighborhood Hits	1762	Target Neighborhood Hits	474	Shared Neighborhood Hits	307
SwissProt Accessions	Q99MW1	Gene names	Stk31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1).

NPTN_MOUSE
NC score	0.295327 (rank : 946)	θ value	0.0736092 (rank : 1064)
Query Neighborhood Hits	1762	Target Neighborhood Hits	216	Shared Neighborhood Hits	195
SwissProt Accessions	P97300, Q3U519, Q8C637, Q8C6H8	Gene names	Nptn, Sdfr1, Sdr1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

KIRR3_HUMAN
NC score	0.294437 (rank : 947)	θ value	1.09739e-05 (rank : 782)
Query Neighborhood Hits	1762	Target Neighborhood Hits	302	Shared Neighborhood Hits	227
SwissProt Accessions	Q8IZU9, Q6UWJ9, Q6UWL5, Q96JG0	Gene names	KIRREL3, KIAA1867, NEPH2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3) (Nephrin-like 2).

KIRR3_MOUSE
NC score	0.292618 (rank : 948)	θ value	8.40245e-06 (rank : 776)
Query Neighborhood Hits	1762	Target Neighborhood Hits	292	Shared Neighborhood Hits	221
SwissProt Accessions	Q8BR86, Q6P555, Q810H3, Q8BGQ5, Q8BRS8	Gene names	Kirrel3, Kiaa1867
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3).

JAM3_HUMAN
NC score	0.288997 (rank : 949)	θ value	0.00175202 (rank : 927)
Query Neighborhood Hits	1762	Target Neighborhood Hits	271	Shared Neighborhood Hits	221
SwissProt Accessions	Q9BX67, Q8WWL8, Q96FL1	Gene names	JAM3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

KIRR1_HUMAN
NC score	0.288144 (rank : 950)	θ value	0.00390308 (rank : 954)
Query Neighborhood Hits	1762	Target Neighborhood Hits	401	Shared Neighborhood Hits	236
SwissProt Accessions	Q96J84, Q5XKC6, Q7Z696, Q7Z7N8, Q8TB15, Q9H9N1, Q9NVA5	Gene names	KIRREL, NEPH1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

ICAM5_HUMAN
NC score	0.288125 (rank : 951)	θ value	0.00509761 (rank : 959)
Query Neighborhood Hits	1762	Target Neighborhood Hits	276	Shared Neighborhood Hits	226
SwissProt Accessions	Q9UMF0, Q9Y6F3	Gene names	ICAM5, TLCN, TLN
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

HMCN1_HUMAN
NC score	0.288036 (rank : 952)	θ value	1.16164e-39 (rank : 20)
Query Neighborhood Hits	1762	Target Neighborhood Hits	983	Shared Neighborhood Hits	334
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

JAM3_MOUSE
NC score	0.287914 (rank : 953)	θ value	0.00298849 (rank : 940)
Query Neighborhood Hits	1762	Target Neighborhood Hits	286	Shared Neighborhood Hits	225
SwissProt Accessions	Q9D8B7, Q8BT59, Q9D1M9, Q9EPK4	Gene names	Jam3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

PGBM_HUMAN
NC score	0.287597 (rank : 954)	θ value	9.20422e-37 (rank : 21)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1113	Shared Neighborhood Hits	359
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

JAM1_HUMAN
NC score	0.286718 (rank : 955)	θ value	0.47712 (rank : 1174)
Query Neighborhood Hits	1762	Target Neighborhood Hits	294	Shared Neighborhood Hits	233
SwissProt Accessions	Q9Y624	Gene names	F11R, JAM1, JCAM
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet adhesion molecule 1) (PAM-1) (Platelet F11 receptor) (CD321 antigen).

MUC18_MOUSE
NC score	0.285345 (rank : 956)	θ value	0.000461057 (rank : 889)
Query Neighborhood Hits	1762	Target Neighborhood Hits	292	Shared Neighborhood Hits	215
SwissProt Accessions	Q8R2Y2, Q9EPF1, Q9ESS7, Q9JHQ2, Q9JHQ3	Gene names	Mcam, Muc18
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Gicerin).

MUC18_HUMAN
NC score	0.285293 (rank : 957)	θ value	0.365318 (rank : 1158)
Query Neighborhood Hits	1762	Target Neighborhood Hits	275	Shared Neighborhood Hits	219
SwissProt Accessions	P43121, O95812, Q59E86, Q6PHR3, Q6ZTR2	Gene names	MCAM, MUC18
Domain Architecture
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (S-endo 1 endothelial-associated antigen) (Cell surface glycoprotein P1H12) (CD146 antigen).

KIRR1_MOUSE
NC score	0.284283 (rank : 958)	θ value	0.0148317 (rank : 1002)
Query Neighborhood Hits	1762	Target Neighborhood Hits	403	Shared Neighborhood Hits	235
SwissProt Accessions	Q80W68, Q8CIJ4, Q8CJ59, Q923L4	Gene names	Kirrel1, Kirrel, Neph1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

KAZD1_MOUSE
NC score	0.282914 (rank : 959)	θ value	0.00035302 (rank : 878)
Query Neighborhood Hits	1762	Target Neighborhood Hits	281	Shared Neighborhood Hits	202
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

JAM2_HUMAN
NC score	0.281437 (rank : 960)	θ value	0.000461057 (rank : 885)
Query Neighborhood Hits	1762	Target Neighborhood Hits	304	Shared Neighborhood Hits	244
SwissProt Accessions	P57087, Q6UXG6, Q6YNC1	Gene names	JAM2, C21orf43, VEJAM
Domain Architecture
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

PTPRD_MOUSE
NC score	0.281172 (rank : 961)	θ value	1.99529e-15 (rank : 358)
Query Neighborhood Hits	1762	Target Neighborhood Hits	491	Shared Neighborhood Hits	318
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRF_HUMAN
NC score	0.280911 (rank : 962)	θ value	9.90251e-15 (rank : 396)
Query Neighborhood Hits	1762	Target Neighborhood Hits	489	Shared Neighborhood Hits	319
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

LRIG1_HUMAN
NC score	0.280768 (rank : 963)	θ value	2.7842e-17 (rank : 257)
Query Neighborhood Hits	1762	Target Neighborhood Hits	654	Shared Neighborhood Hits	298
SwissProt Accessions	Q96JA1, Q6IQ51, Q96CF9, Q9BYB8, Q9UFI4	Gene names	LRIG1, LIG1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

SIG11_HUMAN
NC score	0.279603 (rank : 964)	θ value	8.40245e-06 (rank : 779)
Query Neighborhood Hits	1762	Target Neighborhood Hits	273	Shared Neighborhood Hits	232
SwissProt Accessions	Q96RL6	Gene names	SIGLEC11
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 11 precursor (Siglec-11) (Sialic acid-binding lectin 11).

JAM1_MOUSE
NC score	0.278730 (rank : 965)	θ value	0.00665767 (rank : 971)
Query Neighborhood Hits	1762	Target Neighborhood Hits	287	Shared Neighborhood Hits	219
SwissProt Accessions	O88792	Gene names	F11r, Jam1, Jcam, Jcam1
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (CD321 antigen).

PGBM_MOUSE
NC score	0.278440 (rank : 966)	θ value	1.57365e-28 (rank : 47)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1073	Shared Neighborhood Hits	338
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

LRIG2_HUMAN
NC score	0.278347 (rank : 967)	θ value	4.44505e-15 (rank : 376)
Query Neighborhood Hits	1762	Target Neighborhood Hits	595	Shared Neighborhood Hits	288
SwissProt Accessions	O94898, Q9NSN2	Gene names	LRIG2, KIAA0806, LIG2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor (LIG-2).

CI094_HUMAN
NC score	0.277590 (rank : 968)	θ value	3.41135e-07 (rank : 717)
Query Neighborhood Hits	1762	Target Neighborhood Hits	310	Shared Neighborhood Hits	229
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

VRK3_HUMAN
NC score	0.277559 (rank : 969)	θ value	8.99809 (rank : 1757)
Query Neighborhood Hits	1762	Target Neighborhood Hits	349	Shared Neighborhood Hits	324
SwissProt Accessions	Q8IV63, Q9P2V8	Gene names	VRK3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

LRIG2_MOUSE
NC score	0.277318 (rank : 970)	θ value	6.85773e-16 (rank : 334)
Query Neighborhood Hits	1762	Target Neighborhood Hits	586	Shared Neighborhood Hits	286
SwissProt Accessions	Q52KR2, Q69ZY8	Gene names	Lrig2, Kiaa0806
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor.

PTPRD_HUMAN
NC score	0.275871 (rank : 971)	θ value	8.95645e-16 (rank : 342)
Query Neighborhood Hits	1762	Target Neighborhood Hits	485	Shared Neighborhood Hits	310
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

LRIG1_MOUSE
NC score	0.274969 (rank : 972)	θ value	4.02038e-16 (rank : 328)
Query Neighborhood Hits	1762	Target Neighborhood Hits	627	Shared Neighborhood Hits	288
SwissProt Accessions	P70193	Gene names	Lrig1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

SIG10_HUMAN
NC score	0.274081 (rank : 973)	θ value	1.87187e-05 (rank : 804)
Query Neighborhood Hits	1762	Target Neighborhood Hits	363	Shared Neighborhood Hits	261
SwissProt Accessions	Q96LC7, Q6UXI8, Q96G54, Q96LC8	Gene names	SIGLEC10, SLG2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 10 precursor (Siglec-10) (Siglec- like protein 2).

K2002_MOUSE
NC score	0.273674 (rank : 974)	θ value	0.0330416 (rank : 1031)
Query Neighborhood Hits	1762	Target Neighborhood Hits	267	Shared Neighborhood Hits	233
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

PTPRS_HUMAN
NC score	0.272967 (rank : 975)	θ value	6.64225e-11 (rank : 549)
Query Neighborhood Hits	1762	Target Neighborhood Hits	472	Shared Neighborhood Hits	311
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

IGS4B_MOUSE
NC score	0.272865 (rank : 976)	θ value	0.00102713 (rank : 909)
Query Neighborhood Hits	1762	Target Neighborhood Hits	328	Shared Neighborhood Hits	230
SwissProt Accessions	Q99N28, Q8BSQ8, Q8K1H8	Gene names	Igsf4b, Necl1, Syncam3, Tsll1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (Necl-1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3).

JAM2_MOUSE
NC score	0.272774 (rank : 977)	θ value	0.00869519 (rank : 983)
Query Neighborhood Hits	1762	Target Neighborhood Hits	292	Shared Neighborhood Hits	230
SwissProt Accessions	Q9JI59, Q8C5K9, Q8CE95	Gene names	Jam2, Vejam
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

VSIG2_HUMAN
NC score	0.272729 (rank : 978)	θ value	4.1701e-05 (rank : 824)
Query Neighborhood Hits	1762	Target Neighborhood Hits	321	Shared Neighborhood Hits	219
SwissProt Accessions	Q96IQ7, O95791, Q9NX42	Gene names	VSIG2, CTH, CTXL
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

MFA3L_HUMAN
NC score	0.266725 (rank : 979)	θ value	0.0330416 (rank : 1033)
Query Neighborhood Hits	1762	Target Neighborhood Hits	230	Shared Neighborhood Hits	209
SwissProt Accessions	O75121, Q6TNA8, Q9BVE1, Q9BXK0	Gene names	MFAP3L, KIAA0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor (Protein kinase NYD-SP9).

LRIG3_MOUSE
NC score	0.266415 (rank : 980)	θ value	1.29331e-14 (rank : 399)
Query Neighborhood Hits	1762	Target Neighborhood Hits	611	Shared Neighborhood Hits	289
SwissProt Accessions	Q6P1C6, Q6ZPE6, Q8BRF0, Q8BS51, Q8C5E4	Gene names	Lrig3, Kiaa3016
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor.

CEAM5_HUMAN
NC score	0.266400 (rank : 981)	θ value	0.00228821 (rank : 933)
Query Neighborhood Hits	1762	Target Neighborhood Hits	343	Shared Neighborhood Hits	245
SwissProt Accessions	P06731	Gene names	CEACAM5, CEA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 5 precursor (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD66e antigen).

IGS4B_HUMAN
NC score	0.264548 (rank : 982)	θ value	0.00665767 (rank : 970)
Query Neighborhood Hits	1762	Target Neighborhood Hits	305	Shared Neighborhood Hits	221
SwissProt Accessions	Q8N126, Q9NVJ5, Q9UJP1	Gene names	IGSF4B, NECL1, SYNCAM3, TSLL1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3) (Brain immunoglobulin receptor).

LRIG3_HUMAN
NC score	0.263604 (rank : 983)	θ value	9.90251e-15 (rank : 391)
Query Neighborhood Hits	1762	Target Neighborhood Hits	601	Shared Neighborhood Hits	290
SwissProt Accessions	Q6UXM1, Q6UXL7, Q8NC72	Gene names	LRIG3, LIG3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor (LIG-3).

BASI_HUMAN
NC score	0.262384 (rank : 984)	θ value	0.125558 (rank : 1085)
Query Neighborhood Hits	1762	Target Neighborhood Hits	211	Shared Neighborhood Hits	188
SwissProt Accessions	P35613, Q7Z796, Q8IZL7	Gene names	BSG
Domain Architecture
Description	Basigin precursor (Leukocyte activation antigen M6) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (5F7) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (OK blood group antigen) (CD147 antigen).

VSIG2_MOUSE
NC score	0.262042 (rank : 985)	θ value	0.00390308 (rank : 958)
Query Neighborhood Hits	1762	Target Neighborhood Hits	316	Shared Neighborhood Hits	209
SwissProt Accessions	Q9Z109, Q9CVA4, Q9D0T4	Gene names	Vsig2, Ctm, Ctxl
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

CEA20_HUMAN
NC score	0.261786 (rank : 986)	θ value	0.000602161 (rank : 891)
Query Neighborhood Hits	1762	Target Neighborhood Hits	251	Shared Neighborhood Hits	195
SwissProt Accessions	Q6UY09	Gene names	CEACAM20
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 20 precursor.

NTKL_HUMAN
NC score	0.259203 (rank : 987)	θ value	θ > 10 (rank : 1863)
Query Neighborhood Hits	1762	Target Neighborhood Hits	266	Shared Neighborhood Hits	228
SwissProt Accessions	Q96KG9, Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53	Gene names	SCYL1, GKLP, NTKL, TAPK, TEIF, TRAP
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (Teratoma- associated tyrosine kinase) (Telomerase transcriptional element- interacting factor) (Telomerase regulation-associated protein).

KAZD1_HUMAN
NC score	0.257781 (rank : 988)	θ value	0.00134147 (rank : 919)
Query Neighborhood Hits	1762	Target Neighborhood Hits	248	Shared Neighborhood Hits	168
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

NRG2_HUMAN
NC score	0.256593 (rank : 989)	θ value	0.00665767 (rank : 973)
Query Neighborhood Hits	1762	Target Neighborhood Hits	419	Shared Neighborhood Hits	257
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

CEAM1_MOUSE
NC score	0.255592 (rank : 990)	θ value	θ > 10 (rank : 1782)
Query Neighborhood Hits	1762	Target Neighborhood Hits	326	Shared Neighborhood Hits	241
SwissProt Accessions	P31809	Gene names	Ceacam1, Bgp, Bgp1, Bgpd
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (Murine hepatitis virus receptor) (MHV-R) (Biliary glycoprotein D).

BASI_MOUSE
NC score	0.254470 (rank : 991)	θ value	0.62314 (rank : 1192)
Query Neighborhood Hits	1762	Target Neighborhood Hits	238	Shared Neighborhood Hits	200
SwissProt Accessions	P18572, Q6LDB0, Q7TSC0	Gene names	Bsg
Domain Architecture
Description	Basigin precursor (Basic immunoglobulin superfamily) (Membrane glycoprotein gp42) (HT7 antigen) (CD147 antigen).

VRK3_MOUSE
NC score	0.253853 (rank : 992)	θ value	θ > 10 (rank : 1937)
Query Neighborhood Hits	1762	Target Neighborhood Hits	342	Shared Neighborhood Hits	324
SwissProt Accessions	Q8K3G5, Q921W6	Gene names	Vrk3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

NRG2_MOUSE
NC score	0.248796 (rank : 993)	θ value	0.00298849 (rank : 942)
Query Neighborhood Hits	1762	Target Neighborhood Hits	392	Shared Neighborhood Hits	240
SwissProt Accessions	P56974	Gene names	Nrg2
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)].

IBP7_HUMAN
NC score	0.246840 (rank : 994)	θ value	0.00665767 (rank : 968)
Query Neighborhood Hits	1762	Target Neighborhood Hits	220	Shared Neighborhood Hits	165
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

FCRL5_HUMAN
NC score	0.240696 (rank : 995)	θ value	θ > 10 (rank : 1816)
Query Neighborhood Hits	1762	Target Neighborhood Hits	267	Shared Neighborhood Hits	211
SwissProt Accessions	Q96RD9, Q495Q2, Q495Q4, Q5VYK9, Q6UY46	Gene names	FCRL5, FCRH5, IRTA2
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 5 precursor (Immunoglobulin receptor translocation-associated gene 2 protein) (BXMAS1) (CD307 antigen).

CEAM1_HUMAN
NC score	0.236699 (rank : 996)	θ value	0.00390308 (rank : 951)
Query Neighborhood Hits	1762	Target Neighborhood Hits	348	Shared Neighborhood Hits	228
SwissProt Accessions	P13688, O60430, Q13858, Q15600, Q9UQV9	Gene names	CEACAM1, BGP, BGP1
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (CD66 antigen) (CD66a antigen).

IBP7_MOUSE
NC score	0.236443 (rank : 997)	θ value	0.00665767 (rank : 969)
Query Neighborhood Hits	1762	Target Neighborhood Hits	230	Shared Neighborhood Hits	161
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

FNDC3_MOUSE
NC score	0.232014 (rank : 998)	θ value	2.36792 (rank : 1406)
Query Neighborhood Hits	1762	Target Neighborhood Hits	207	Shared Neighborhood Hits	131
SwissProt Accessions	Q8BX90, Q2VEY7, Q6ZQ15, Q811D3, Q8BTM3	Gene names	Fndc3a, D14Ertd453e, Fndc3, Kiaa0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

FCRL2_HUMAN
NC score	0.231280 (rank : 999)	θ value	θ > 10 (rank : 1815)
Query Neighborhood Hits	1762	Target Neighborhood Hits	251	Shared Neighborhood Hits	191
SwissProt Accessions	Q96LA5, Q6NTA1, Q9BZI4, Q9BZI5, Q9BZI6	Gene names	FCRL2, FCRH2, IFGP4, IRTA4, SPAP1
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 2 precursor (SH2 domain-containing phosphatase anchor protein 1) (Fc receptor homolog 2) (FcRH2) (Immunoglobulin receptor translocation-associated 4 protein).

FNDC3_HUMAN
NC score	0.231107 (rank : 1000)	θ value	2.36792 (rank : 1405)
Query Neighborhood Hits	1762	Target Neighborhood Hits	196	Shared Neighborhood Hits	131
SwissProt Accessions	Q9Y2H6, Q5JVF9, Q6EVH3, Q6N020, Q6P9D5, Q9H1W1	Gene names	FNDC3A, FNDC3, KIAA0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

VSIG4_HUMAN
NC score	0.230373 (rank : 1001)	θ value	0.62314 (rank : 1215)
Query Neighborhood Hits	1762	Target Neighborhood Hits	236	Shared Neighborhood Hits	184
SwissProt Accessions	Q9Y279, Q6UXI4	Gene names	VSIG4, Z39IG
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 4 precursor (Protein Z39Ig).

MFA3L_MOUSE
NC score	0.225088 (rank : 1002)	θ value	0.125558 (rank : 1097)
Query Neighborhood Hits	1762	Target Neighborhood Hits	214	Shared Neighborhood Hits	193
SwissProt Accessions	Q9D3X9, Q80TV6, Q8BJA9	Gene names	Mfap3l, Kiaa0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor.

CD166_MOUSE
NC score	0.222083 (rank : 1003)	θ value	0.47712 (rank : 1170)
Query Neighborhood Hits	1762	Target Neighborhood Hits	252	Shared Neighborhood Hits	185
SwissProt Accessions	Q61490, O70136, Q8CDA5, Q8R2T0	Gene names	Alcam
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM) (DM-GRASP protein).

SIGL5_MOUSE
NC score	0.220029 (rank : 1004)	θ value	0.00228821 (rank : 937)
Query Neighborhood Hits	1762	Target Neighborhood Hits	271	Shared Neighborhood Hits	218
SwissProt Accessions	Q920G3	Gene names	Siglec5, Siglecf
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Sialic acid-binding Ig-like lectin-F) (mSiglec-F).

GPA33_MOUSE
NC score	0.218458 (rank : 1005)	θ value	0.0431538 (rank : 1042)
Query Neighborhood Hits	1762	Target Neighborhood Hits	294	Shared Neighborhood Hits	177
SwissProt Accessions	Q9JKA5, Q922D5	Gene names	Gpa33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33) (mA33).

ATL3_HUMAN
NC score	0.212254 (rank : 1006)	θ value	8.40245e-06 (rank : 774)
Query Neighborhood Hits	1762	Target Neighborhood Hits	414	Shared Neighborhood Hits	261
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

CD166_HUMAN
NC score	0.207455 (rank : 1007)	θ value	2.36792 (rank : 1397)
Query Neighborhood Hits	1762	Target Neighborhood Hits	247	Shared Neighborhood Hits	178
SwissProt Accessions	Q13740, O60892	Gene names	ALCAM, MEMD
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM).

GPA33_HUMAN
NC score	0.204818 (rank : 1008)	θ value	2.36792 (rank : 1410)
Query Neighborhood Hits	1762	Target Neighborhood Hits	273	Shared Neighborhood Hits	175
SwissProt Accessions	Q99795	Gene names	GPA33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33).

CEAM6_HUMAN
NC score	0.200566 (rank : 1009)	θ value	1.06291 (rank : 1259)
Query Neighborhood Hits	1762	Target Neighborhood Hits	308	Shared Neighborhood Hits	223
SwissProt Accessions	P40199, Q14920	Gene names	CEACAM6, NCA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 6 precursor (Normal cross-reacting antigen) (Nonspecific crossreacting antigen) (CD66c antigen).

NRG1_HUMAN
NC score	0.194704 (rank : 1010)	θ value	0.00134147 (rank : 924)
Query Neighborhood Hits	1762	Target Neighborhood Hits	285	Shared Neighborhood Hits	168
SwissProt Accessions	Q02297, O14667, P98202, Q02298, Q02299, Q07110, Q07111, Q12779, Q12780, Q12781, Q12782, Q12783, Q12784, Q7RTV9, Q7RTW0, Q7RTW1, Q7RTW2, Q8NFN1, Q8NFN2, Q8NFN3, Q9UPE3	Gene names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Domain Architecture
Description	Pro-neuregulin-1, membrane-bound isoform precursor (Pro-NRG1) [Contains: Neuregulin-1 (Neu differentiation factor) (Heregulin) (HRG) (Breast cancer cell differentiation factor p45) (Acetylcholine receptor-inducing activity) (ARIA) (Sensory and motor neuron-derived factor) (Glial growth factor)].

ESAM_HUMAN
NC score	0.193122 (rank : 1011)	θ value	0.125558 (rank : 1090)
Query Neighborhood Hits	1762	Target Neighborhood Hits	251	Shared Neighborhood Hits	186
SwissProt Accessions	Q96AP7, Q96T50	Gene names	ESAM
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

SIGL8_HUMAN
NC score	0.191263 (rank : 1012)	θ value	5.44631e-05 (rank : 830)
Query Neighborhood Hits	1762	Target Neighborhood Hits	252	Shared Neighborhood Hits	213
SwissProt Accessions	Q9NYZ4, Q7Z728	Gene names	SIGLEC8, SAF2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 8 precursor (Siglec-8) (Sialoadhesin family member 2) (SAF-2) (CDw329 antigen).

SIGL5_HUMAN
NC score	0.190368 (rank : 1013)	θ value	0.00509761 (rank : 962)
Query Neighborhood Hits	1762	Target Neighborhood Hits	246	Shared Neighborhood Hits	187
SwissProt Accessions	O15389	Gene names	SIGLEC5, CD33L2, OBBP2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Obesity- binding protein 2) (OB-binding protein 2) (OB-BP2) (CD33 antigen-like 2) (CD170 antigen).

LRFN4_HUMAN
NC score	0.189352 (rank : 1014)	θ value	0.000602161 (rank : 896)
Query Neighborhood Hits	1762	Target Neighborhood Hits	462	Shared Neighborhood Hits	222
SwissProt Accessions	Q6PJG9, Q9BWJ0	Gene names	LRFN4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

LRFN4_MOUSE
NC score	0.187895 (rank : 1015)	θ value	7.1131e-05 (rank : 835)
Query Neighborhood Hits	1762	Target Neighborhood Hits	442	Shared Neighborhood Hits	214
SwissProt Accessions	Q80XU8, Q3TQG8, Q8K3C4	Gene names	Lrfn4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

LRFN2_HUMAN
NC score	0.185835 (rank : 1016)	θ value	0.000786445 (rank : 902)
Query Neighborhood Hits	1762	Target Neighborhood Hits	450	Shared Neighborhood Hits	216
SwissProt Accessions	Q9ULH4, Q5SYP9	Gene names	LRFN2, KIAA1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

LRFN2_MOUSE
NC score	0.185755 (rank : 1017)	θ value	0.000461057 (rank : 887)
Query Neighborhood Hits	1762	Target Neighborhood Hits	450	Shared Neighborhood Hits	220
SwissProt Accessions	Q80TG9, Q9CYK3	Gene names	Lrfn2, Kiaa1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

LRFN3_MOUSE
NC score	0.185089 (rank : 1018)	θ value	7.1131e-05 (rank : 834)
Query Neighborhood Hits	1762	Target Neighborhood Hits	455	Shared Neighborhood Hits	220
SwissProt Accessions	Q8BLY3	Gene names	Lrfn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

CILP2_HUMAN
NC score	0.183570 (rank : 1019)	θ value	0.0252991 (rank : 1013)
Query Neighborhood Hits	1762	Target Neighborhood Hits	307	Shared Neighborhood Hits	190
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

IL1R2_HUMAN
NC score	0.179120 (rank : 1020)	θ value	1.38821 (rank : 1316)
Query Neighborhood Hits	1762	Target Neighborhood Hits	153	Shared Neighborhood Hits	123
SwissProt Accessions	P27930, Q9UE68	Gene names	IL1R2, IL1RB
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen) (CDw121b).

SIG12_HUMAN
NC score	0.178903 (rank : 1021)	θ value	0.00298849 (rank : 944)
Query Neighborhood Hits	1762	Target Neighborhood Hits	245	Shared Neighborhood Hits	210
SwissProt Accessions	Q96PQ1, Q8IYH7	Gene names	SIGLEC12, SIGLECL1, SLG
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1).

LRFN3_HUMAN
NC score	0.177786 (rank : 1022)	θ value	4.1701e-05 (rank : 821)
Query Neighborhood Hits	1762	Target Neighborhood Hits	444	Shared Neighborhood Hits	213
SwissProt Accessions	Q9BTN0, Q6UY10	Gene names	LRFN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

CEAM8_HUMAN
NC score	0.176390 (rank : 1023)	θ value	0.62314 (rank : 1194)
Query Neighborhood Hits	1762	Target Neighborhood Hits	264	Shared Neighborhood Hits	206
SwissProt Accessions	P31997, O60399, Q16574	Gene names	CEACAM8, CGM6
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 8 precursor (Carcinoembryonic antigen CGM6) (Nonspecific cross-reacting antigen NCA-95) (CD67 antigen) (CD66b antigen).

ESAM_MOUSE
NC score	0.176053 (rank : 1024)	θ value	1.38821 (rank : 1306)
Query Neighborhood Hits	1762	Target Neighborhood Hits	222	Shared Neighborhood Hits	166
SwissProt Accessions	Q925F2	Gene names	Esam, Esam1
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

SIGL6_HUMAN
NC score	0.174520 (rank : 1025)	θ value	0.00298849 (rank : 945)
Query Neighborhood Hits	1762	Target Neighborhood Hits	233	Shared Neighborhood Hits	192
SwissProt Accessions	O43699, O15388, O43700	Gene names	SIGLEC6, CD33L, CD33L1, OBBP1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 6 precursor (Siglec-6) (Obesity- binding protein 1) (OB-BP1) (CD33 antigen-like 1) (CDw327 antigen).

LRC21_MOUSE
NC score	0.173784 (rank : 1026)	θ value	0.00134147 (rank : 922)
Query Neighborhood Hits	1762	Target Neighborhood Hits	462	Shared Neighborhood Hits	225
SwissProt Accessions	Q8K099, Q8BXN3	Gene names	Lrrc21, Pal
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

PSG3_HUMAN
NC score	0.173762 (rank : 1027)	θ value	0.0431538 (rank : 1048)
Query Neighborhood Hits	1762	Target Neighborhood Hits	242	Shared Neighborhood Hits	192
SwissProt Accessions	Q16557, Q08265, Q9BRW2, Q9UPL4, Q9UQ77	Gene names	PSG3
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 3 precursor (PSBG-3) (Carcinoembryonic antigen SG5).

LRFN5_MOUSE
NC score	0.173730 (rank : 1028)	θ value	0.000121331 (rank : 853)
Query Neighborhood Hits	1762	Target Neighborhood Hits	472	Shared Neighborhood Hits	225
SwissProt Accessions	Q8BXA0, Q8BJH4, Q8BZL0	Gene names	Lrfn5
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

PSG8_HUMAN
NC score	0.173464 (rank : 1029)	θ value	0.21417 (rank : 1129)
Query Neighborhood Hits	1762	Target Neighborhood Hits	239	Shared Neighborhood Hits	189
SwissProt Accessions	Q9UQ74, O60410	Gene names	PSG8
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 8 precursor (PSBG-8).

PXK_MOUSE
NC score	0.173075 (rank : 1030)	θ value	θ > 10 (rank : 1893)
Query Neighborhood Hits	1762	Target Neighborhood Hits	320	Shared Neighborhood Hits	220
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

LRC21_HUMAN
NC score	0.172512 (rank : 1031)	θ value	0.00175202 (rank : 928)
Query Neighborhood Hits	1762	Target Neighborhood Hits	456	Shared Neighborhood Hits	220
SwissProt Accessions	Q9P2V4, Q9Y4N7	Gene names	LRRC21, PAL
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

PSG4_HUMAN
NC score	0.171031 (rank : 1032)	θ value	1.06291 (rank : 1281)
Query Neighborhood Hits	1762	Target Neighborhood Hits	243	Shared Neighborhood Hits	192
SwissProt Accessions	Q00888, Q13047, Q13048, Q15234, Q15240, Q9UQ76	Gene names	PSG4, CGM4, PSG9
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 4 precursor (PSBG-4) (PSBG-9).

LRFN5_HUMAN
NC score	0.169977 (rank : 1033)	θ value	0.00020696 (rank : 868)
Query Neighborhood Hits	1762	Target Neighborhood Hits	464	Shared Neighborhood Hits	221
SwissProt Accessions	Q96NI6, Q86XL2	Gene names	LRFN5, C14orf146
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

PSG7_HUMAN
NC score	0.164687 (rank : 1034)	θ value	2.36792 (rank : 1431)
Query Neighborhood Hits	1762	Target Neighborhood Hits	239	Shared Neighborhood Hits	190
SwissProt Accessions	Q13046, Q15232	Gene names	PSG7
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 7 precursor (PSBG-7).

IRPL2_HUMAN
NC score	0.163828 (rank : 1035)	θ value	0.00390308 (rank : 952)
Query Neighborhood Hits	1762	Target Neighborhood Hits	194	Shared Neighborhood Hits	140
SwissProt Accessions	Q9NP60, Q9NZN0	Gene names	IL1RAPL2, IL1R9
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (Interleukin-1 receptor 9) (IL-1R9) (IL-1 receptor accessory protein-like 2) (Three immunoglobulin domain- containing IL-1 receptor-related 1) (TIGIRR-1).

PSG11_HUMAN
NC score	0.163476 (rank : 1036)	θ value	2.36792 (rank : 1430)
Query Neighborhood Hits	1762	Target Neighborhood Hits	223	Shared Neighborhood Hits	186
SwissProt Accessions	Q9UQ72, Q13179, Q15242, Q9UNE4	Gene names	PSG11, PSG13
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 11 precursor (PSBG-11) (PSBG- 13).

CXAR_HUMAN
NC score	0.162346 (rank : 1037)	θ value	θ > 10 (rank : 1798)
Query Neighborhood Hits	1762	Target Neighborhood Hits	245	Shared Neighborhood Hits	154
SwissProt Accessions	P78310, O00694, Q8WWT6, Q8WWT7, Q8WWT8, Q9UKV4	Gene names	CXADR, CAR
Domain Architecture
Description	Coxsackievirus and adenovirus receptor precursor (Coxsackievirus B- adenovirus receptor) (hCAR) (CVB3-binding protein) (HCVADR).

PSG2_HUMAN
NC score	0.162158 (rank : 1038)	θ value	0.279714 (rank : 1148)
Query Neighborhood Hits	1762	Target Neighborhood Hits	229	Shared Neighborhood Hits	184
SwissProt Accessions	P11465, Q8TCD9, Q9UEA4, Q9UQ78	Gene names	PSG2
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 2 precursor (PSBG-2) (Pregnancy-specific beta-1 glycoprotein E) (PS-beta-E).

PSG1_HUMAN
NC score	0.161682 (rank : 1039)	θ value	1.81305 (rank : 1370)
Query Neighborhood Hits	1762	Target Neighborhood Hits	232	Shared Neighborhood Hits	190
SwissProt Accessions	P11464, O75236, P11462, P11463, Q15231, Q15241, Q15243, Q16660, Q9P1W5, Q9UQ79	Gene names	PSG1, B1G1, PSGGA
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 1 precursor (PSBG-1) (Pregnancy-specific beta-1 glycoprotein C/D) (PS-beta-C/D) (Fetal liver non-specific cross-reactive antigen 1/2) (FL-NCA-1/2) (PSG95) (CD66f antigen).

IRPL2_MOUSE
NC score	0.161543 (rank : 1040)	θ value	0.00390308 (rank : 953)
Query Neighborhood Hits	1762	Target Neighborhood Hits	195	Shared Neighborhood Hits	138
SwissProt Accessions	Q9ERS6, Q9ER66	Gene names	Il1rapl2
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (TIGIRR-1).

IRPL1_MOUSE
NC score	0.160523 (rank : 1041)	θ value	0.00228821 (rank : 935)
Query Neighborhood Hits	1762	Target Neighborhood Hits	186	Shared Neighborhood Hits	147
SwissProt Accessions	P59823	Gene names	Il1rapl1
Domain Architecture	No domain graphic available
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1).

CILP1_MOUSE
NC score	0.158120 (rank : 1042)	θ value	0.0431538 (rank : 1041)
Query Neighborhood Hits	1762	Target Neighborhood Hits	282	Shared Neighborhood Hits	188
SwissProt Accessions	Q66K08, Q7TSS0, Q7TSS1, Q8BV01	Gene names	Cilp
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

PSG6_HUMAN
NC score	0.158098 (rank : 1043)	θ value	1.38821 (rank : 1330)
Query Neighborhood Hits	1762	Target Neighborhood Hits	231	Shared Neighborhood Hits	184
SwissProt Accessions	Q00889	Gene names	PSG6, CGM3, PSGGB
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 6 precursor (PSBG-6).

IL1R2_MOUSE
NC score	0.156935 (rank : 1044)	θ value	0.0330416 (rank : 1030)
Query Neighborhood Hits	1762	Target Neighborhood Hits	125	Shared Neighborhood Hits	97
SwissProt Accessions	P27931	Gene names	Il1r2, Il-1r2, Il1rb
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen).

IRPL1_HUMAN
NC score	0.155970 (rank : 1045)	θ value	0.00228821 (rank : 934)
Query Neighborhood Hits	1762	Target Neighborhood Hits	196	Shared Neighborhood Hits	151
SwissProt Accessions	Q9NZN1, Q9UJ53	Gene names	IL1RAPL1, OPHN4
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2).

PSG10_HUMAN
NC score	0.154225 (rank : 1046)	θ value	8.99809 (rank : 1736)
Query Neighborhood Hits	1762	Target Neighborhood Hits	227	Shared Neighborhood Hits	182
SwissProt Accessions	Q15235, O75244, Q15224	Gene names	PSG10, PSG12
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 10 precursor (PSBG-10) (PSBG- 12).

LRRN3_HUMAN
NC score	0.153228 (rank : 1047)	θ value	0.0193708 (rank : 1007)
Query Neighborhood Hits	1762	Target Neighborhood Hits	461	Shared Neighborhood Hits	222
SwissProt Accessions	Q9H3W5, O43377, Q6I9V8, Q8IYQ6	Gene names	LRRN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

PSG9_HUMAN
NC score	0.153044 (rank : 1048)	θ value	0.47712 (rank : 1185)
Query Neighborhood Hits	1762	Target Neighborhood Hits	221	Shared Neighborhood Hits	182
SwissProt Accessions	Q00887, Q15236, Q15237, Q8WW78, Q9UQ73	Gene names	PSG9, PSG11
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 9 precursor (PSBG-9) (Pregnancy-specific glycoprotein 9) (Pregnancy-specific beta-1 glycoprotein B) (PS-beta-B) (PS34) (Pregnancy-specific glycoprotein 7) (PSG7).

CXAR_MOUSE
NC score	0.152913 (rank : 1049)	θ value	θ > 10 (rank : 1799)
Query Neighborhood Hits	1762	Target Neighborhood Hits	250	Shared Neighborhood Hits	153
SwissProt Accessions	P97792, O09052, Q3ULD0, Q91W66, Q99KG0, Q9DBJ8	Gene names	Cxadr, Car
Domain Architecture
Description	Coxsackievirus and adenovirus receptor homolog precursor (CAR) (mCAR).

FINC_MOUSE
NC score	0.151975 (rank : 1050)	θ value	4.03905 (rank : 1506)
Query Neighborhood Hits	1762	Target Neighborhood Hits	309	Shared Neighborhood Hits	157
SwissProt Accessions	P11276, Q61567, Q61568, Q61569, Q64233, Q80UI4	Gene names	Fn1
Domain Architecture
Description	Fibronectin precursor (FN).

UNC5D_MOUSE
NC score	0.151196 (rank : 1051)	θ value	0.21417 (rank : 1134)
Query Neighborhood Hits	1762	Target Neighborhood Hits	268	Shared Neighborhood Hits	177
SwissProt Accessions	Q8K1S2	Gene names	Unc5d, Unc5h4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

FINC_HUMAN
NC score	0.150599 (rank : 1052)	θ value	0.47712 (rank : 1173)
Query Neighborhood Hits	1762	Target Neighborhood Hits	302	Shared Neighborhood Hits	149
SwissProt Accessions	P02751, O95609, O95610, Q14312, Q14325, Q14326, Q6LDP6, Q86T27, Q8IVI8, Q96KP7, Q96KP8, Q96KP9, Q9H1B8, Q9HAP3, Q9UMK2	Gene names	FN1, FN
Domain Architecture
Description	Fibronectin precursor (FN) (Cold-insoluble globulin) (CIG).

PGFRL_HUMAN
NC score	0.150419 (rank : 1053)	θ value	5.27518 (rank : 1578)
Query Neighborhood Hits	1762	Target Neighborhood Hits	115	Shared Neighborhood Hits	111
SwissProt Accessions	Q15198, Q6FH04	Gene names	PDGFRL, PRLTS
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor (PDGF receptor beta-like tumor suppressor).

PSG5_HUMAN
NC score	0.150148 (rank : 1054)	θ value	6.88961 (rank : 1645)
Query Neighborhood Hits	1762	Target Neighborhood Hits	231	Shared Neighborhood Hits	182
SwissProt Accessions	Q15238, Q15239, Q96QJ1, Q9UQ75	Gene names	PSG5
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 5 precursor (PSBG-5) (Fetal liver non-specific cross-reactive antigen 3) (FL-NCA-3).

CILP1_HUMAN
NC score	0.149897 (rank : 1055)	θ value	0.0148317 (rank : 1000)
Query Neighborhood Hits	1762	Target Neighborhood Hits	266	Shared Neighborhood Hits	171
SwissProt Accessions	O75339, Q6UW99, Q8IYI5	Gene names	CILP
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) (Cartilage intermediate-layer protein) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

UNC5D_HUMAN
NC score	0.149348 (rank : 1056)	θ value	0.21417 (rank : 1133)
Query Neighborhood Hits	1762	Target Neighborhood Hits	267	Shared Neighborhood Hits	177
SwissProt Accessions	Q6UXZ4, Q8WYP7	Gene names	UNC5D, KIAA1777, UNC5H4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

LRRN1_HUMAN
NC score	0.148553 (rank : 1057)	θ value	0.163984 (rank : 1110)
Query Neighborhood Hits	1762	Target Neighborhood Hits	518	Shared Neighborhood Hits	246
SwissProt Accessions	Q6UXK5, Q3LID5, Q8IYV5, Q9H8V1, Q9P231	Gene names	LRRN1, KIAA1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

CD276_HUMAN
NC score	0.147146 (rank : 1058)	θ value	θ > 10 (rank : 1776)
Query Neighborhood Hits	1762	Target Neighborhood Hits	261	Shared Neighborhood Hits	146
SwissProt Accessions	Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1	Gene names	CD276, B7H3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3) (4Ig-B7-H3).

PRPK_HUMAN
NC score	0.146203 (rank : 1059)	θ value	θ > 10 (rank : 1878)
Query Neighborhood Hits	1762	Target Neighborhood Hits	131	Shared Neighborhood Hits	127
SwissProt Accessions	Q96S44, Q3T977, Q5JZ01, Q96FM7, Q9NQE6	Gene names	TP53RK, C20orf64, PRPK
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PRPK_MOUSE
NC score	0.145811 (rank : 1060)	θ value	θ > 10 (rank : 1879)
Query Neighborhood Hits	1762	Target Neighborhood Hits	139	Shared Neighborhood Hits	130
SwissProt Accessions	Q99PW4, Q91W37, Q9CZ32	Gene names	Tp53rk, Prpk, Trp53rk
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

LRRN3_MOUSE
NC score	0.144711 (rank : 1061)	θ value	0.0330416 (rank : 1032)
Query Neighborhood Hits	1762	Target Neighborhood Hits	455	Shared Neighborhood Hits	218
SwissProt Accessions	Q8CBC6, P97860	Gene names	Lrrn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

PECA1_HUMAN
NC score	0.144631 (rank : 1062)	θ value	θ > 10 (rank : 1874)
Query Neighborhood Hits	1762	Target Neighborhood Hits	178	Shared Neighborhood Hits	139
SwissProt Accessions	P16284, Q6LDA9, Q8TBH1, Q96RF5, Q96RF6, Q9NP65, Q9NPB7, Q9NPG9, Q9NQS9, Q9NQT0, Q9NQT1, Q9NQT2	Gene names	PECAM1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (EndoCAM) (GPIIA') (CD31 antigen).

LRRN5_HUMAN
NC score	0.144495 (rank : 1063)	θ value	0.0148317 (rank : 1003)
Query Neighborhood Hits	1762	Target Neighborhood Hits	493	Shared Neighborhood Hits	236
SwissProt Accessions	O75325, Q5T0Y0, Q6UXM0, Q8N182	Gene names	LRRN5, GAC1, LRRN2
Domain Architecture
Description	Leucine-rich repeats neuronal protein 5 precursor (Glioma amplified on chromosome 1 protein).

LRRN1_MOUSE
NC score	0.143032 (rank : 1064)	θ value	0.163984 (rank : 1111)
Query Neighborhood Hits	1762	Target Neighborhood Hits	508	Shared Neighborhood Hits	244
SwissProt Accessions	Q61809, Q3USY1, Q69ZI0	Gene names	Lrrn1, Kiaa1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

RN5A_HUMAN
NC score	0.140112 (rank : 1065)	θ value	θ > 10 (rank : 1900)
Query Neighborhood Hits	1762	Target Neighborhood Hits	608	Shared Neighborhood Hits	335
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

SIGL7_HUMAN
NC score	0.139533 (rank : 1066)	θ value	0.0252991 (rank : 1019)
Query Neighborhood Hits	1762	Target Neighborhood Hits	180	Shared Neighborhood Hits	151
SwissProt Accessions	Q9Y286, Q9NZQ1, Q9UJ86, Q9UJ87, Q9Y502	Gene names	SIGLEC7, AIRM1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 7 precursor (Siglec-7) (QA79 membrane protein) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (p75) (D-siglec) (CDw328 antigen).

TARSH_HUMAN
NC score	0.136493 (rank : 1067)	θ value	0.0961366 (rank : 1082)
Query Neighborhood Hits	1762	Target Neighborhood Hits	768	Shared Neighborhood Hits	317
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

PVRL3_MOUSE
NC score	0.136277 (rank : 1068)	θ value	θ > 10 (rank : 1890)
Query Neighborhood Hits	1762	Target Neighborhood Hits	212	Shared Neighborhood Hits	143
SwissProt Accessions	Q9JLB9, Q9D006, Q9JLB7, Q9JLB8	Gene names	Pvrl3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Cell adhesion molecule nectin-3) (Nectin-3) (CDw113 antigen).

IL6RB_HUMAN
NC score	0.135838 (rank : 1069)	θ value	θ > 10 (rank : 1837)
Query Neighborhood Hits	1762	Target Neighborhood Hits	181	Shared Neighborhood Hits	103
SwissProt Accessions	P40189, Q9UQ41	Gene names	IL6ST
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin M receptor) (CD130 antigen) (CDw130).

PGFRL_MOUSE
NC score	0.135592 (rank : 1070)	θ value	2.36792 (rank : 1428)
Query Neighborhood Hits	1762	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	Q6PE55, Q3V182, Q9D0Z1	Gene names	Pdgfrl
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor.

LRC24_HUMAN
NC score	0.134216 (rank : 1071)	θ value	0.000461057 (rank : 886)
Query Neighborhood Hits	1762	Target Neighborhood Hits	404	Shared Neighborhood Hits	193
SwissProt Accessions	Q50LG9	Gene names	LRRC24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

IL1R1_HUMAN
NC score	0.133486 (rank : 1072)	θ value	0.813845 (rank : 1233)
Query Neighborhood Hits	1762	Target Neighborhood Hits	140	Shared Neighborhood Hits	116
SwissProt Accessions	P14778	Gene names	IL1R1, IL1R, IL1RA, IL1RT1
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (IL-1RT1) (IL-1R- alpha) (p80) (CD121a antigen).

PVRL3_HUMAN
NC score	0.131614 (rank : 1073)	θ value	θ > 10 (rank : 1889)
Query Neighborhood Hits	1762	Target Neighborhood Hits	204	Shared Neighborhood Hits	137
SwissProt Accessions	Q9NQS3, Q6NVZ3, Q8WVU4, Q9BVA9, Q9Y412	Gene names	PVRL3, PRR3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Nectin-3) (CDw113 antigen).

USH2A_HUMAN
NC score	0.130212 (rank : 1074)	θ value	0.0252991 (rank : 1021)
Query Neighborhood Hits	1762	Target Neighborhood Hits	600	Shared Neighborhood Hits	161
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

ILRL2_MOUSE
NC score	0.129051 (rank : 1075)	θ value	0.0563607 (rank : 1059)
Query Neighborhood Hits	1762	Target Neighborhood Hits	158	Shared Neighborhood Hits	137
SwissProt Accessions	Q9ERS7	Gene names	Il1rl2
Domain Architecture
Description	Interleukin-1 receptor-like 2 precursor (IL-1Rrp2).

PXK_HUMAN
NC score	0.127507 (rank : 1076)	θ value	θ > 10 (rank : 1892)
Query Neighborhood Hits	1762	Target Neighborhood Hits	216	Shared Neighborhood Hits	152
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

SIG12_MOUSE
NC score	0.126531 (rank : 1077)	θ value	0.47712 (rank : 1188)
Query Neighborhood Hits	1762	Target Neighborhood Hits	225	Shared Neighborhood Hits	161
SwissProt Accessions	Q91Y57	Gene names	Siglec12, Siglec5, Siglece, Siglecl1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1) (Sialic acid-binding Ig-like lectin 5) (Siglec-5) (mSiglec-E) (Myeloid inhibitory siglec) (MIS).

PVRL1_HUMAN
NC score	0.124496 (rank : 1078)	θ value	θ > 10 (rank : 1885)
Query Neighborhood Hits	1762	Target Neighborhood Hits	219	Shared Neighborhood Hits	153
SwissProt Accessions	Q15223, O75465, Q9HBE6, Q9HBW2	Gene names	PVRL1, HVEC, PRR1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (Herpesvirus Ig-like receptor) (HIgR) (CD111 antigen).

USH2A_MOUSE
NC score	0.124194 (rank : 1079)	θ value	0.0252991 (rank : 1022)
Query Neighborhood Hits	1762	Target Neighborhood Hits	626	Shared Neighborhood Hits	170
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

PIGR_MOUSE
NC score	0.124042 (rank : 1080)	θ value	θ > 10 (rank : 1876)
Query Neighborhood Hits	1762	Target Neighborhood Hits	214	Shared Neighborhood Hits	122
SwissProt Accessions	O70570	Gene names	Pigr
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) [Contains: Secretory component].

EMB_MOUSE
NC score	0.123757 (rank : 1081)	θ value	θ > 10 (rank : 1809)
Query Neighborhood Hits	1762	Target Neighborhood Hits	83	Shared Neighborhood Hits	73
SwissProt Accessions	P21995, Q3UFF1, Q8C2J8, Q8C543, Q96C38	Gene names	Emb, Gp70
Domain Architecture
Description	Embigin precursor (Teratocarcinoma glycoprotein Gp-70).

ILRL1_HUMAN
NC score	0.123251 (rank : 1082)	θ value	0.0113563 (rank : 991)
Query Neighborhood Hits	1762	Target Neighborhood Hits	167	Shared Neighborhood Hits	121
SwissProt Accessions	Q01638, Q53TU7, Q8NEJ3, Q9ULV7, Q9UQ44	Gene names	IL1RL1, DER4, ST2, T1
Domain Architecture
Description	Interleukin-1 receptor-like 1 precursor (ST2 protein).

ITB4_HUMAN
NC score	0.122043 (rank : 1083)	θ value	θ > 10 (rank : 1845)
Query Neighborhood Hits	1762	Target Neighborhood Hits	458	Shared Neighborhood Hits	150
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

LRC4B_MOUSE
NC score	0.121158 (rank : 1084)	θ value	0.125558 (rank : 1094)
Query Neighborhood Hits	1762	Target Neighborhood Hits	484	Shared Neighborhood Hits	210
SwissProt Accessions	P0C192	Gene names	Lrrc4b, Lrig4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

NGL1_HUMAN
NC score	0.120615 (rank : 1085)	θ value	0.00869519 (rank : 984)
Query Neighborhood Hits	1762	Target Neighborhood Hits	511	Shared Neighborhood Hits	220
SwissProt Accessions	Q9HCJ2, Q7L0N3	Gene names	LRRC4C, KIAA1580, NGL1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

NGL1_MOUSE
NC score	0.120572 (rank : 1086)	θ value	0.0113563 (rank : 994)
Query Neighborhood Hits	1762	Target Neighborhood Hits	512	Shared Neighborhood Hits	220
SwissProt Accessions	Q8C031, Q8BGH8	Gene names	Lrrc4c, Ngl1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

LRC4B_HUMAN
NC score	0.120092 (rank : 1087)	θ value	0.125558 (rank : 1093)
Query Neighborhood Hits	1762	Target Neighborhood Hits	479	Shared Neighborhood Hits	207
SwissProt Accessions	Q9NT99, Q3ZCQ4, Q58F20	Gene names	LRRC4B, LRIG4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

IL1R1_MOUSE
NC score	0.119958 (rank : 1088)	θ value	θ > 10 (rank : 1836)
Query Neighborhood Hits	1762	Target Neighborhood Hits	142	Shared Neighborhood Hits	120
SwissProt Accessions	P13504	Gene names	Il1r1, Il-1r1, Il1ra
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (p80) (CD121a antigen).

UNC5A_HUMAN
NC score	0.119753 (rank : 1089)	θ value	0.365318 (rank : 1166)
Query Neighborhood Hits	1762	Target Neighborhood Hits	198	Shared Neighborhood Hits	131
SwissProt Accessions	Q6ZN44, Q8TF26, Q96GP4	Gene names	UNC5A, KIAA1976, UNC5H1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

MOX2R_MOUSE
NC score	0.119096 (rank : 1090)	θ value	θ > 10 (rank : 1858)
Query Neighborhood Hits	1762	Target Neighborhood Hits	110	Shared Neighborhood Hits	88
SwissProt Accessions	Q9ES57	Gene names	Cd200r1, Mox2r, Ox2r
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor).

PECA1_MOUSE
NC score	0.118814 (rank : 1091)	θ value	0.813845 (rank : 1243)
Query Neighborhood Hits	1762	Target Neighborhood Hits	126	Shared Neighborhood Hits	98
SwissProt Accessions	Q08481	Gene names	Pecam1, Pecam, Pecam-1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (CD31 antigen).

LRC24_MOUSE
NC score	0.118683 (rank : 1092)	θ value	0.813845 (rank : 1238)
Query Neighborhood Hits	1762	Target Neighborhood Hits	387	Shared Neighborhood Hits	190
SwissProt Accessions	Q8BHA1	Gene names	Lrrc24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

UNC5C_MOUSE
NC score	0.118119 (rank : 1093)	θ value	1.81305 (rank : 1384)
Query Neighborhood Hits	1762	Target Neighborhood Hits	225	Shared Neighborhood Hits	143
SwissProt Accessions	O08747, Q8CD16	Gene names	Unc5c, Rcm, Unc5h3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3) (Rostral cerebellar malformation protein).

PIGR_HUMAN
NC score	0.116932 (rank : 1094)	θ value	θ > 10 (rank : 1875)
Query Neighborhood Hits	1762	Target Neighborhood Hits	164	Shared Neighborhood Hits	99
SwissProt Accessions	P01833, Q8IZY7	Gene names	PIGR
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) (Hepatocellular carcinoma-associated protein TB6) [Contains: Secretory component].

UNC5C_HUMAN
NC score	0.116695 (rank : 1095)	θ value	4.03905 (rank : 1534)
Query Neighborhood Hits	1762	Target Neighborhood Hits	226	Shared Neighborhood Hits	138
SwissProt Accessions	O95185, Q8IUT0	Gene names	UNC5C, UNC5H3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3).

PDL1_HUMAN
NC score	0.115771 (rank : 1096)	θ value	θ > 10 (rank : 1869)
Query Neighborhood Hits	1762	Target Neighborhood Hits	195	Shared Neighborhood Hits	126
SwissProt Accessions	Q9NZQ7, Q66RK1, Q6WEX4, Q9NUZ5	Gene names	CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

CD276_MOUSE
NC score	0.115428 (rank : 1097)	θ value	θ > 10 (rank : 1777)
Query Neighborhood Hits	1762	Target Neighborhood Hits	243	Shared Neighborhood Hits	150
SwissProt Accessions	Q8VE98	Gene names	Cd276, B7h3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3).

IL6RB_MOUSE
NC score	0.115254 (rank : 1098)	θ value	θ > 10 (rank : 1838)
Query Neighborhood Hits	1762	Target Neighborhood Hits	168	Shared Neighborhood Hits	103
SwissProt Accessions	Q00560	Gene names	Il6st
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (CD130 antigen).

PVRL1_MOUSE
NC score	0.114615 (rank : 1099)	θ value	θ > 10 (rank : 1886)
Query Neighborhood Hits	1762	Target Neighborhood Hits	201	Shared Neighborhood Hits	141
SwissProt Accessions	Q9JKF6, Q9ERL5, Q9JI17	Gene names	Pvrl1, Hvec, Prr1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (CD111 antigen).

SRRM1_MOUSE
NC score	0.114280 (rank : 1100)	θ value	0.00869519 (rank : 988)
Query Neighborhood Hits	1762	Target Neighborhood Hits	966	Shared Neighborhood Hits	351
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

COCA1_MOUSE
NC score	0.113485 (rank : 1101)	θ value	θ > 10 (rank : 1791)
Query Neighborhood Hits	1762	Target Neighborhood Hits	467	Shared Neighborhood Hits	213
SwissProt Accessions	Q60847, P70322	Gene names	Col12a1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

UNC5B_HUMAN
NC score	0.111722 (rank : 1102)	θ value	0.813845 (rank : 1250)
Query Neighborhood Hits	1762	Target Neighborhood Hits	225	Shared Neighborhood Hits	136
SwissProt Accessions	Q8IZJ1, Q86SN3, Q8N1Y2, Q9H9F3	Gene names	UNC5B, P53RDL1, UNC5H2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2) (p53-regulated receptor for death and life protein 1).

KALM_HUMAN
NC score	0.109567 (rank : 1103)	θ value	θ > 10 (rank : 1847)
Query Neighborhood Hits	1762	Target Neighborhood Hits	114	Shared Neighborhood Hits	70
SwissProt Accessions	P23352	Gene names	KAL1, ADMLX, KAL, KALIG1
Domain Architecture
Description	Anosmin-1 precursor (Kallmann syndrome protein) (Adhesion molecule- like X-linked).

LIFR_HUMAN
NC score	0.109318 (rank : 1104)	θ value	θ > 10 (rank : 1850)
Query Neighborhood Hits	1762	Target Neighborhood Hits	130	Shared Neighborhood Hits	75
SwissProt Accessions	P42702, Q6LCD9	Gene names	LIFR
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (CD118 antigen).

UNC5B_MOUSE
NC score	0.109203 (rank : 1105)	θ value	1.38821 (rank : 1345)
Query Neighborhood Hits	1762	Target Neighborhood Hits	226	Shared Neighborhood Hits	139
SwissProt Accessions	Q8K1S3, Q3U4F2, Q6PFH0, Q80Y85, Q9D398	Gene names	Unc5b, Unc5h2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2).

HCFC2_MOUSE
NC score	0.108053 (rank : 1106)	θ value	6.88961 (rank : 1622)
Query Neighborhood Hits	1762	Target Neighborhood Hits	97	Shared Neighborhood Hits	85
SwissProt Accessions	Q9D968	Gene names	Hcfc2
Domain Architecture	No domain graphic available
Description	Host cell factor 2 (HCF-2) (C2 factor).

LAG3_MOUSE
NC score	0.107322 (rank : 1107)	θ value	0.0431538 (rank : 1044)
Query Neighborhood Hits	1762	Target Neighborhood Hits	117	Shared Neighborhood Hits	83
SwissProt Accessions	Q61790, Q0VBL2	Gene names	Lag3
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (CD223 antigen).

COCA1_HUMAN
NC score	0.106233 (rank : 1108)	θ value	θ > 10 (rank : 1790)
Query Neighborhood Hits	1762	Target Neighborhood Hits	458	Shared Neighborhood Hits	199
SwissProt Accessions	Q99715, Q99716	Gene names	COL12A1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

PVR_HUMAN
NC score	0.105758 (rank : 1109)	θ value	θ > 10 (rank : 1891)
Query Neighborhood Hits	1762	Target Neighborhood Hits	195	Shared Neighborhood Hits	118
SwissProt Accessions	P15151, P15152, Q15267, Q15268, Q96BJ1	Gene names	PVR, PVS
Domain Architecture
Description	Poliovirus receptor precursor (Nectin-like protein 5) (Necl-5) (CD155 antigen).

IGS21_HUMAN
NC score	0.105710 (rank : 1110)	θ value	θ > 10 (rank : 1833)
Query Neighborhood Hits	1762	Target Neighborhood Hits	123	Shared Neighborhood Hits	98
SwissProt Accessions	Q96ID5, Q8NBR8	Gene names	IGSF21
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 21 precursor.

LRRC4_HUMAN
NC score	0.105468 (rank : 1111)	θ value	1.38821 (rank : 1321)
Query Neighborhood Hits	1762	Target Neighborhood Hits	444	Shared Neighborhood Hits	195
SwissProt Accessions	Q9HBW1, Q6ZMI8, Q96A85	Gene names	LRRC4, BAG
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4 precursor (Brain tumor- associated protein LRRC4) (NAG14).

PDL2_MOUSE
NC score	0.104739 (rank : 1112)	θ value	θ > 10 (rank : 1872)
Query Neighborhood Hits	1762	Target Neighborhood Hits	116	Shared Neighborhood Hits	86
SwissProt Accessions	Q9WUL5	Gene names	Pdcd1lg2, B7dc, Btdc, Cd273, Pdl2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

IGS21_MOUSE
NC score	0.104690 (rank : 1113)	θ value	θ > 10 (rank : 1834)
Query Neighborhood Hits	1762	Target Neighborhood Hits	118	Shared Neighborhood Hits	95
SwissProt Accessions	Q7TNR6	Gene names	Igsf21
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 21 precursor.

SRRM2_MOUSE
NC score	0.104217 (rank : 1114)	θ value	0.125558 (rank : 1100)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1470	Shared Neighborhood Hits	424
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

UNC5A_MOUSE
NC score	0.103826 (rank : 1115)	θ value	0.47712 (rank : 1190)
Query Neighborhood Hits	1762	Target Neighborhood Hits	203	Shared Neighborhood Hits	127
SwissProt Accessions	Q8K1S4, Q6PEF7, Q80T71	Gene names	Unc5a, Kiaa1976, Unc5h1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

PVRL2_MOUSE
NC score	0.103212 (rank : 1116)	θ value	θ > 10 (rank : 1888)
Query Neighborhood Hits	1762	Target Neighborhood Hits	242	Shared Neighborhood Hits	123
SwissProt Accessions	P32507, Q62096	Gene names	Pvrl2, Mph, Pvr, Pvs
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Murine herpesvirus entry protein B) (mHveB) (Nectin-2) (Poliovirus receptor homolog) (CD112 antigen).

CEAM7_HUMAN
NC score	0.102531 (rank : 1117)	θ value	θ > 10 (rank : 1783)
Query Neighborhood Hits	1762	Target Neighborhood Hits	170	Shared Neighborhood Hits	129
SwissProt Accessions	Q14002, O15148, O15149, Q13983, Q9UPJ2	Gene names	CEACAM7, CGM2
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 7 precursor (Carcinoembryonic antigen CGM2).

BUB1B_HUMAN
NC score	0.102169 (rank : 1118)	θ value	θ > 10 (rank : 1774)
Query Neighborhood Hits	1762	Target Neighborhood Hits	208	Shared Neighborhood Hits	113
SwissProt Accessions	O60566, O60501, O60627, O60758, O75389, Q96KM4	Gene names	BUB1B, BUBR1, MAD3L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (hBUBR1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L) (SSK1).

PTPRM_HUMAN
NC score	0.101853 (rank : 1119)	θ value	5.27518 (rank : 1582)
Query Neighborhood Hits	1762	Target Neighborhood Hits	244	Shared Neighborhood Hits	136
SwissProt Accessions	P28827	Gene names	PTPRM, PTPRL1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

I12R2_MOUSE
NC score	0.101683 (rank : 1120)	θ value	θ > 10 (rank : 1830)
Query Neighborhood Hits	1762	Target Neighborhood Hits	143	Shared Neighborhood Hits	88
SwissProt Accessions	P97378	Gene names	Il12rb2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

SRRM2_HUMAN
NC score	0.101499 (rank : 1121)	θ value	0.00509761 (rank : 963)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1296	Shared Neighborhood Hits	395
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

I12R2_HUMAN
NC score	0.100924 (rank : 1122)	θ value	θ > 10 (rank : 1829)
Query Neighborhood Hits	1762	Target Neighborhood Hits	163	Shared Neighborhood Hits	93
SwissProt Accessions	Q99665	Gene names	IL12RB2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

SLAP2_MOUSE
NC score	0.100718 (rank : 1123)	θ value	θ > 10 (rank : 1912)
Query Neighborhood Hits	1762	Target Neighborhood Hits	136	Shared Neighborhood Hits	47
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

LIFR_MOUSE
NC score	0.100523 (rank : 1124)	θ value	θ > 10 (rank : 1851)
Query Neighborhood Hits	1762	Target Neighborhood Hits	127	Shared Neighborhood Hits	70
SwissProt Accessions	P42703	Gene names	Lifr
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (D-factor/LIF receptor) (CD118 antigen).

PTPRM_MOUSE
NC score	0.099420 (rank : 1125)	θ value	5.27518 (rank : 1583)
Query Neighborhood Hits	1762	Target Neighborhood Hits	238	Shared Neighborhood Hits	135
SwissProt Accessions	P28828	Gene names	Ptprm
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

NACAM_MOUSE
NC score	0.098560 (rank : 1126)	θ value	0.00175202 (rank : 929)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1866	Shared Neighborhood Hits	518
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

JAML1_MOUSE
NC score	0.097922 (rank : 1127)	θ value	4.03905 (rank : 1513)
Query Neighborhood Hits	1762	Target Neighborhood Hits	185	Shared Neighborhood Hits	108
SwissProt Accessions	Q80UL9, Q5DTC4	Gene names	Amica1, Gm638, Jaml
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule-like precursor (mCrea7).

SLAP2_HUMAN
NC score	0.097713 (rank : 1128)	θ value	θ > 10 (rank : 1911)
Query Neighborhood Hits	1762	Target Neighborhood Hits	139	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP1_HUMAN
NC score	0.096369 (rank : 1129)	θ value	θ > 10 (rank : 1909)
Query Neighborhood Hits	1762	Target Neighborhood Hits	113	Shared Neighborhood Hits	43
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SRRM1_HUMAN
NC score	0.095353 (rank : 1130)	θ value	θ > 10 (rank : 1915)
Query Neighborhood Hits	1762	Target Neighborhood Hits	690	Shared Neighborhood Hits	264
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

SLAP1_MOUSE
NC score	0.094937 (rank : 1131)	θ value	θ > 10 (rank : 1910)
Query Neighborhood Hits	1762	Target Neighborhood Hits	117	Shared Neighborhood Hits	42
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

HHLA2_HUMAN
NC score	0.094840 (rank : 1132)	θ value	1.38821 (rank : 1313)
Query Neighborhood Hits	1762	Target Neighborhood Hits	140	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UM44, Q9NWQ6	Gene names	HHLA2
Domain Architecture	No domain graphic available
Description	HERV-H LTR-associating protein 2 precursor (Human endogenous retrovirus-H long terminal repeat-associating protein 2).

GRP3_HUMAN
NC score	0.092741 (rank : 1133)	θ value	θ > 10 (rank : 1826)
Query Neighborhood Hits	1762	Target Neighborhood Hits	131	Shared Neighborhood Hits	43
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

PVRL2_HUMAN
NC score	0.092652 (rank : 1134)	θ value	θ > 10 (rank : 1887)
Query Neighborhood Hits	1762	Target Neighborhood Hits	185	Shared Neighborhood Hits	117
SwissProt Accessions	Q92692, O75455, Q96J29	Gene names	PVRL2, HVEB, PRR2
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Herpes virus entry mediator B) (HveB) (Nectin-2) (CD112 antigen).

PDL1_MOUSE
NC score	0.091531 (rank : 1135)	θ value	θ > 10 (rank : 1870)
Query Neighborhood Hits	1762	Target Neighborhood Hits	168	Shared Neighborhood Hits	112
SwissProt Accessions	Q9EP73	Gene names	Cd274, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

PRP2_MOUSE
NC score	0.091300 (rank : 1136)	θ value	0.365318 (rank : 1162)
Query Neighborhood Hits	1762	Target Neighborhood Hits	347	Shared Neighborhood Hits	184
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

FCERA_HUMAN
NC score	0.090767 (rank : 1137)	θ value	θ > 10 (rank : 1810)
Query Neighborhood Hits	1762	Target Neighborhood Hits	150	Shared Neighborhood Hits	107
SwissProt Accessions	P12319	Gene names	FCER1A, FCE1A
Domain Architecture
Description	High affinity immunoglobulin epsilon receptor alpha-subunit precursor (FcERI) (IgE Fc receptor, alpha-subunit) (Fc-epsilon RI-alpha).

LRRC4_MOUSE
NC score	0.090113 (rank : 1138)	θ value	5.27518 (rank : 1572)
Query Neighborhood Hits	1762	Target Neighborhood Hits	412	Shared Neighborhood Hits	173
SwissProt Accessions	Q99PH1, Q8VI35	Gene names	Lrrc4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing 4 protein precursor (Brain tumor- associated protein MBAG1).

COEA1_MOUSE
NC score	0.089208 (rank : 1139)	θ value	θ > 10 (rank : 1793)
Query Neighborhood Hits	1762	Target Neighborhood Hits	402	Shared Neighborhood Hits	162
SwissProt Accessions	Q80X19, Q8C6X3, Q9WV05	Gene names	Col14a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor.

PTPRU_HUMAN
NC score	0.086514 (rank : 1140)	θ value	1.38821 (rank : 1331)
Query Neighborhood Hits	1762	Target Neighborhood Hits	237	Shared Neighborhood Hits	131
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

ILRL1_MOUSE
NC score	0.086157 (rank : 1141)	θ value	θ > 10 (rank : 1842)
Query Neighborhood Hits	1762	Target Neighborhood Hits	172	Shared Neighborhood Hits	124
SwissProt Accessions	P14719, Q05208	Gene names	Il1rl1, Ly84, St2, Ste2
Domain Architecture
Description	Interleukin-1 receptor-like 1 precursor (ST2 protein) (T1 protein) (Lymphocyte antigen 84).

STAC_MOUSE
NC score	0.086015 (rank : 1142)	θ value	θ > 10 (rank : 1919)
Query Neighborhood Hits	1762	Target Neighborhood Hits	268	Shared Neighborhood Hits	95
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

PTPRT_MOUSE
NC score	0.085948 (rank : 1143)	θ value	θ > 10 (rank : 1884)
Query Neighborhood Hits	1762	Target Neighborhood Hits	219	Shared Neighborhood Hits	114
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

PTPRT_HUMAN
NC score	0.085393 (rank : 1144)	θ value	θ > 10 (rank : 1883)
Query Neighborhood Hits	1762	Target Neighborhood Hits	217	Shared Neighborhood Hits	114
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

FCGR1_HUMAN
NC score	0.085223 (rank : 1145)	θ value	θ > 10 (rank : 1813)
Query Neighborhood Hits	1762	Target Neighborhood Hits	145	Shared Neighborhood Hits	98
SwissProt Accessions	P12314, P12315, Q92495, Q92663	Gene names	FCGR1A, FCG1, FCGR1, IGFR1
Domain Architecture
Description	High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma RI) (FcRI) (IgG Fc receptor I) (CD64 antigen).

MDC1_HUMAN
NC score	0.084663 (rank : 1146)	θ value	2.88788e-06 (rank : 757)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1446	Shared Neighborhood Hits	386
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

PRP1_HUMAN
NC score	0.084290 (rank : 1147)	θ value	6.88961 (rank : 1643)
Query Neighborhood Hits	1762	Target Neighborhood Hits	385	Shared Neighborhood Hits	193
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

OX2G_MOUSE
NC score	0.083947 (rank : 1148)	θ value	θ > 10 (rank : 1865)
Query Neighborhood Hits	1762	Target Neighborhood Hits	105	Shared Neighborhood Hits	81
SwissProt Accessions	O54901, O54816, Q9JHD5	Gene names	Cd200, Mox2
Domain Architecture
Description	OX-2 membrane glycoprotein precursor (MRC OX-2 antigen) (CD200 antigen).

STAC3_MOUSE
NC score	0.083795 (rank : 1149)	θ value	θ > 10 (rank : 1917)
Query Neighborhood Hits	1762	Target Neighborhood Hits	232	Shared Neighborhood Hits	76
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

BUB1B_MOUSE
NC score	0.083125 (rank : 1150)	θ value	θ > 10 (rank : 1775)
Query Neighborhood Hits	1762	Target Neighborhood Hits	202	Shared Neighborhood Hits	129
SwissProt Accessions	Q9Z1S0	Gene names	Bub1b, Mad3l
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L).

STAC3_HUMAN
NC score	0.083104 (rank : 1151)	θ value	θ > 10 (rank : 1916)
Query Neighborhood Hits	1762	Target Neighborhood Hits	228	Shared Neighborhood Hits	77
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

LAG3_HUMAN
NC score	0.082799 (rank : 1152)	θ value	θ > 10 (rank : 1848)
Query Neighborhood Hits	1762	Target Neighborhood Hits	129	Shared Neighborhood Hits	78
SwissProt Accessions	P18627	Gene names	LAG3, FDC
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (FDC protein) (CD223 antigen).

CO7A1_HUMAN
NC score	0.081935 (rank : 1153)	θ value	θ > 10 (rank : 1789)
Query Neighborhood Hits	1762	Target Neighborhood Hits	807	Shared Neighborhood Hits	285
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

CD79A_HUMAN
NC score	0.081337 (rank : 1154)	θ value	θ > 10 (rank : 1779)
Query Neighborhood Hits	1762	Target Neighborhood Hits	102	Shared Neighborhood Hits	61
SwissProt Accessions	P11912	Gene names	CD79A, IGA, MB1
Domain Architecture
Description	B-cell antigen receptor complex-associated protein alpha-chain precursor (Ig-alpha) (MB-1 membrane glycoprotein) (Surface IgM- associated protein) (Membrane-bound immunoglobulin-associated protein) (CD79a antigen).

PCLO_MOUSE
NC score	0.080921 (rank : 1155)	θ value	0.00665767 (rank : 974)
Query Neighborhood Hits	1762	Target Neighborhood Hits	2275	Shared Neighborhood Hits	553
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

CSF3R_HUMAN
NC score	0.080209 (rank : 1156)	θ value	θ > 10 (rank : 1795)
Query Neighborhood Hits	1762	Target Neighborhood Hits	140	Shared Neighborhood Hits	81
SwissProt Accessions	Q99062	Gene names	CSF3R, GCSFR
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

STAC_HUMAN
NC score	0.079775 (rank : 1157)	θ value	θ > 10 (rank : 1918)
Query Neighborhood Hits	1762	Target Neighborhood Hits	276	Shared Neighborhood Hits	94
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

MUC7_HUMAN
NC score	0.079312 (rank : 1158)	θ value	θ > 10 (rank : 1859)
Query Neighborhood Hits	1762	Target Neighborhood Hits	538	Shared Neighborhood Hits	236
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

BSN_MOUSE
NC score	0.078967 (rank : 1159)	θ value	0.21417 (rank : 1121)
Query Neighborhood Hits	1762	Target Neighborhood Hits	2057	Shared Neighborhood Hits	514
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

PTPRK_MOUSE
NC score	0.078893 (rank : 1160)	θ value	θ > 10 (rank : 1882)
Query Neighborhood Hits	1762	Target Neighborhood Hits	223	Shared Neighborhood Hits	120
SwissProt Accessions	P35822	Gene names	Ptprk, Ptpk
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

BSN_HUMAN
NC score	0.078527 (rank : 1161)	θ value	0.279714 (rank : 1139)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1537	Shared Neighborhood Hits	425
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

PRB4S_HUMAN
NC score	0.078361 (rank : 1162)	θ value	5.27518 (rank : 1581)
Query Neighborhood Hits	1762	Target Neighborhood Hits	330	Shared Neighborhood Hits	178
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

CD80_HUMAN
NC score	0.078346 (rank : 1163)	θ value	θ > 10 (rank : 1780)
Query Neighborhood Hits	1762	Target Neighborhood Hits	129	Shared Neighborhood Hits	87
SwissProt Accessions	P33681	Gene names	CD80, CD28LG, CD28LG1, LAB7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (CTLA-4 counter-receptor B7.1) (B7) (BB1).

PTPRK_HUMAN
NC score	0.077657 (rank : 1164)	θ value	θ > 10 (rank : 1881)
Query Neighborhood Hits	1762	Target Neighborhood Hits	228	Shared Neighborhood Hits	122
SwissProt Accessions	Q15262, Q14763	Gene names	PTPRK, PTPK
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

OGFR_HUMAN
NC score	0.077631 (rank : 1165)	θ value	0.00175202 (rank : 930)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1582	Shared Neighborhood Hits	437
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

TENR_HUMAN
NC score	0.077320 (rank : 1166)	θ value	θ > 10 (rank : 1922)
Query Neighborhood Hits	1762	Target Neighborhood Hits	526	Shared Neighborhood Hits	142
SwissProt Accessions	Q92752, Q15568, Q5R3G0	Gene names	TNR
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin).

PRG4_HUMAN
NC score	0.077213 (rank : 1167)	θ value	6.88961 (rank : 1642)
Query Neighborhood Hits	1762	Target Neighborhood Hits	764	Shared Neighborhood Hits	286
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

ILRL2_HUMAN
NC score	0.077041 (rank : 1168)	θ value	θ > 10 (rank : 1843)
Query Neighborhood Hits	1762	Target Neighborhood Hits	112	Shared Neighborhood Hits	94
SwissProt Accessions	Q9HB29, Q13525, Q45H74	Gene names	IL1RL2, IL1RRP2
Domain Architecture
Description	Interleukin-1 receptor-like 2 precursor (IL-1Rrp2) (Interleukin-1 receptor-related protein 2) (IL1R-rp2).

TENN_MOUSE
NC score	0.077024 (rank : 1169)	θ value	θ > 10 (rank : 1921)
Query Neighborhood Hits	1762	Target Neighborhood Hits	484	Shared Neighborhood Hits	133
SwissProt Accessions	Q80Z71	Gene names	Tnn
Domain Architecture
Description	Tenascin-N precursor (TN-N).

PRR12_HUMAN
NC score	0.076957 (rank : 1170)	θ value	θ > 10 (rank : 1880)
Query Neighborhood Hits	1762	Target Neighborhood Hits	460	Shared Neighborhood Hits	208
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

WASIP_HUMAN
NC score	0.076794 (rank : 1171)	θ value	θ > 10 (rank : 1938)
Query Neighborhood Hits	1762	Target Neighborhood Hits	458	Shared Neighborhood Hits	235
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

PCLO_HUMAN
NC score	0.076757 (rank : 1172)	θ value	0.0563607 (rank : 1060)
Query Neighborhood Hits	1762	Target Neighborhood Hits	2046	Shared Neighborhood Hits	493
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

MDC1_MOUSE
NC score	0.076603 (rank : 1173)	θ value	0.00390308 (rank : 956)
Query Neighborhood Hits	1762	Target Neighborhood Hits	998	Shared Neighborhood Hits	303
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

ICAM1_MOUSE
NC score	0.076482 (rank : 1174)	θ value	θ > 10 (rank : 1832)
Query Neighborhood Hits	1762	Target Neighborhood Hits	99	Shared Neighborhood Hits	83
SwissProt Accessions	P13597, Q61828	Gene names	Icam1, Icam-1
Domain Architecture
Description	Intercellular adhesion molecule 1 precursor (ICAM-1) (MALA-2).

PDZD8_HUMAN
NC score	0.076419 (rank : 1175)	θ value	θ > 10 (rank : 1873)
Query Neighborhood Hits	1762	Target Neighborhood Hits	185	Shared Neighborhood Hits	65
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PDL2_HUMAN
NC score	0.076065 (rank : 1176)	θ value	θ > 10 (rank : 1871)
Query Neighborhood Hits	1762	Target Neighborhood Hits	114	Shared Neighborhood Hits	74
SwissProt Accessions	Q9BQ51, Q5T7Z6, Q6JXL8, Q6JXL9	Gene names	PDCD1LG2, B7DC, CD273, PDCD1L2, PDL2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

VAV_HUMAN
NC score	0.075186 (rank : 1177)	θ value	θ > 10 (rank : 1935)
Query Neighborhood Hits	1762	Target Neighborhood Hits	452	Shared Neighborhood Hits	108
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

CD80_MOUSE
NC score	0.075101 (rank : 1178)	θ value	θ > 10 (rank : 1781)
Query Neighborhood Hits	1762	Target Neighborhood Hits	136	Shared Neighborhood Hits	92
SwissProt Accessions	Q00609, Q61332	Gene names	Cd80, B7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (B7).

GRAP_HUMAN
NC score	0.075056 (rank : 1179)	θ value	θ > 10 (rank : 1822)
Query Neighborhood Hits	1762	Target Neighborhood Hits	307	Shared Neighborhood Hits	81
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

BASP_MOUSE
NC score	0.074984 (rank : 1180)	θ value	0.813845 (rank : 1219)
Query Neighborhood Hits	1762	Target Neighborhood Hits	260	Shared Neighborhood Hits	114
SwissProt Accessions	Q91XV3	Gene names	Basp1, Nap22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

PRRT3_HUMAN
NC score	0.074678 (rank : 1181)	θ value	0.00298849 (rank : 943)
Query Neighborhood Hits	1762	Target Neighborhood Hits	998	Shared Neighborhood Hits	342
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

GRAP_MOUSE
NC score	0.074032 (rank : 1182)	θ value	θ > 10 (rank : 1823)
Query Neighborhood Hits	1762	Target Neighborhood Hits	309	Shared Neighborhood Hits	79
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

VAV3_HUMAN
NC score	0.073853 (rank : 1183)	θ value	θ > 10 (rank : 1933)
Query Neighborhood Hits	1762	Target Neighborhood Hits	398	Shared Neighborhood Hits	102
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

BASP_HUMAN
NC score	0.073814 (rank : 1184)	θ value	0.62314 (rank : 1193)
Query Neighborhood Hits	1762	Target Neighborhood Hits	321	Shared Neighborhood Hits	122
SwissProt Accessions	P80723, O43596, Q5U0S0	Gene names	BASP1, NAP22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

VAV3_MOUSE
NC score	0.073781 (rank : 1185)	θ value	θ > 10 (rank : 1934)
Query Neighborhood Hits	1762	Target Neighborhood Hits	404	Shared Neighborhood Hits	107
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

SORL_HUMAN
NC score	0.073652 (rank : 1186)	θ value	θ > 10 (rank : 1913)
Query Neighborhood Hits	1762	Target Neighborhood Hits	440	Shared Neighborhood Hits	121
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

TENR_MOUSE
NC score	0.073583 (rank : 1187)	θ value	θ > 10 (rank : 1923)
Query Neighborhood Hits	1762	Target Neighborhood Hits	531	Shared Neighborhood Hits	135
SwissProt Accessions	Q8BYI9, O88717	Gene names	Tnr
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin) (Neural recognition molecule J1-160/180).

RASF1_MOUSE
NC score	0.073508 (rank : 1188)	θ value	θ > 10 (rank : 1896)
Query Neighborhood Hits	1762	Target Neighborhood Hits	74	Shared Neighborhood Hits	33
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

COEA1_HUMAN
NC score	0.073176 (rank : 1189)	θ value	θ > 10 (rank : 1792)
Query Neighborhood Hits	1762	Target Neighborhood Hits	427	Shared Neighborhood Hits	169
SwissProt Accessions	Q05707, O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67	Gene names	COL14A1, UND
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor (Undulin).

UN13A_HUMAN
NC score	0.073101 (rank : 1190)	θ value	θ > 10 (rank : 1928)
Query Neighborhood Hits	1762	Target Neighborhood Hits	285	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

MFAP3_HUMAN
NC score	0.072837 (rank : 1191)	θ value	θ > 10 (rank : 1854)
Query Neighborhood Hits	1762	Target Neighborhood Hits	91	Shared Neighborhood Hits	80
SwissProt Accessions	P55082, Q9NXA7	Gene names	MFAP3
Domain Architecture
Description	Microfibril-associated glycoprotein 3 precursor.

SORL_MOUSE
NC score	0.072596 (rank : 1192)	θ value	θ > 10 (rank : 1914)
Query Neighborhood Hits	1762	Target Neighborhood Hits	439	Shared Neighborhood Hits	127
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

ICAM1_HUMAN
NC score	0.071958 (rank : 1193)	θ value	θ > 10 (rank : 1831)
Query Neighborhood Hits	1762	Target Neighborhood Hits	80	Shared Neighborhood Hits	67
SwissProt Accessions	P05362, Q96B50	Gene names	ICAM1
Domain Architecture
Description	Intercellular adhesion molecule 1 precursor (ICAM-1) (Major group rhinovirus receptor) (CD54 antigen).

GRAP2_HUMAN
NC score	0.071860 (rank : 1194)	θ value	θ > 10 (rank : 1820)
Query Neighborhood Hits	1762	Target Neighborhood Hits	304	Shared Neighborhood Hits	76
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRB2_HUMAN
NC score	0.071842 (rank : 1195)	θ value	θ > 10 (rank : 1824)
Query Neighborhood Hits	1762	Target Neighborhood Hits	310	Shared Neighborhood Hits	76
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.071786 (rank : 1196)	θ value	θ > 10 (rank : 1825)
Query Neighborhood Hits	1762	Target Neighborhood Hits	312	Shared Neighborhood Hits	76
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

VAV2_HUMAN
NC score	0.071442 (rank : 1197)	θ value	θ > 10 (rank : 1931)
Query Neighborhood Hits	1762	Target Neighborhood Hits	453	Shared Neighborhood Hits	111
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

BAT2_HUMAN
NC score	0.071169 (rank : 1198)	θ value	0.279714 (rank : 1137)
Query Neighborhood Hits	1762	Target Neighborhood Hits	931	Shared Neighborhood Hits	337
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

DCX_HUMAN
NC score	0.070757 (rank : 1199)	θ value	θ > 10 (rank : 1801)
Query Neighborhood Hits	1762	Target Neighborhood Hits	141	Shared Neighborhood Hits	66
SwissProt Accessions	O43602, O43911	Gene names	DCX, DBCN, LISX
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

GSCR1_HUMAN
NC score	0.070622 (rank : 1200)	θ value	θ > 10 (rank : 1827)
Query Neighborhood Hits	1762	Target Neighborhood Hits	674	Shared Neighborhood Hits	275
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

OX2G_HUMAN
NC score	0.070467 (rank : 1201)	θ value	θ > 10 (rank : 1864)
Query Neighborhood Hits	1762	Target Neighborhood Hits	100	Shared Neighborhood Hits	68
SwissProt Accessions	P41217, Q6J2Q6, Q6PIQ4, Q8TB85, Q9H3J3	Gene names	CD200, MOX2
Domain Architecture
Description	OX-2 membrane glycoprotein precursor (CD200 antigen).

VAV_MOUSE
NC score	0.070450 (rank : 1202)	θ value	θ > 10 (rank : 1936)
Query Neighborhood Hits	1762	Target Neighborhood Hits	430	Shared Neighborhood Hits	110
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

GRAP2_MOUSE
NC score	0.070355 (rank : 1203)	θ value	θ > 10 (rank : 1821)
Query Neighborhood Hits	1762	Target Neighborhood Hits	297	Shared Neighborhood Hits	74
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

PACE1_MOUSE
NC score	0.070311 (rank : 1204)	θ value	θ > 10 (rank : 1867)
Query Neighborhood Hits	1762	Target Neighborhood Hits	92	Shared Neighborhood Hits	64
SwissProt Accessions	Q9DBQ7, Q6NY01, Q8BQC9, Q8BRJ1	Gene names	Scyl3, Pace1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

PRG4_MOUSE
NC score	0.070142 (rank : 1205)	θ value	8.99809 (rank : 1733)
Query Neighborhood Hits	1762	Target Neighborhood Hits	624	Shared Neighborhood Hits	233
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

ICAM3_HUMAN
NC score	0.069465 (rank : 1206)	θ value	8.99809 (rank : 1706)
Query Neighborhood Hits	1762	Target Neighborhood Hits	100	Shared Neighborhood Hits	82
SwissProt Accessions	P32942	Gene names	ICAM3
Domain Architecture
Description	Intercellular adhesion molecule 3 precursor (ICAM-3) (ICAM-R) (CDw50) (CD50 antigen).

TAF4_HUMAN
NC score	0.069310 (rank : 1207)	θ value	1.81305 (rank : 1380)
Query Neighborhood Hits	1762	Target Neighborhood Hits	687	Shared Neighborhood Hits	239
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

PRB3_HUMAN
NC score	0.069188 (rank : 1208)	θ value	θ > 10 (rank : 1877)
Query Neighborhood Hits	1762	Target Neighborhood Hits	318	Shared Neighborhood Hits	166
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

VAV2_MOUSE
NC score	0.069038 (rank : 1209)	θ value	θ > 10 (rank : 1932)
Query Neighborhood Hits	1762	Target Neighborhood Hits	456	Shared Neighborhood Hits	112
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

UN13B_HUMAN
NC score	0.068796 (rank : 1210)	θ value	θ > 10 (rank : 1929)
Query Neighborhood Hits	1762	Target Neighborhood Hits	217	Shared Neighborhood Hits	52
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

NCK1_HUMAN
NC score	0.068300 (rank : 1211)	θ value	θ > 10 (rank : 1860)
Query Neighborhood Hits	1762	Target Neighborhood Hits	312	Shared Neighborhood Hits	76
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
NC score	0.068167 (rank : 1212)	θ value	θ > 10 (rank : 1861)
Query Neighborhood Hits	1762	Target Neighborhood Hits	310	Shared Neighborhood Hits	75
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

SON_HUMAN
NC score	0.068079 (rank : 1213)	θ value	0.000461057 (rank : 890)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1568	Shared Neighborhood Hits	406
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

CHIO_HUMAN
NC score	0.067876 (rank : 1214)	θ value	θ > 10 (rank : 1786)
Query Neighborhood Hits	1762	Target Neighborhood Hits	220	Shared Neighborhood Hits	66
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

NCOA6_HUMAN
NC score	0.067867 (rank : 1215)	θ value	0.00509761 (rank : 960)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1202	Shared Neighborhood Hits	376
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

MFAP3_MOUSE
NC score	0.067739 (rank : 1216)	θ value	θ > 10 (rank : 1855)
Query Neighborhood Hits	1762	Target Neighborhood Hits	97	Shared Neighborhood Hits	85
SwissProt Accessions	Q922T2, Q8BHK5	Gene names	Mfap3
Domain Architecture	No domain graphic available
Description	Microfibril-associated glycoprotein 3 precursor.

DGKD_HUMAN
NC score	0.067671 (rank : 1217)	θ value	θ > 10 (rank : 1804)
Query Neighborhood Hits	1762	Target Neighborhood Hits	231	Shared Neighborhood Hits	78
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

HCFC2_HUMAN
NC score	0.067253 (rank : 1218)	θ value	1.81305 (rank : 1363)
Query Neighborhood Hits	1762	Target Neighborhood Hits	154	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y5Z7	Gene names	HCFC2
Domain Architecture	No domain graphic available
Description	Host cell factor 2 (HCF-2) (C2 factor).

CHIN_MOUSE
NC score	0.067251 (rank : 1219)	θ value	θ > 10 (rank : 1785)
Query Neighborhood Hits	1762	Target Neighborhood Hits	229	Shared Neighborhood Hits	67
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

EMB_HUMAN
NC score	0.067160 (rank : 1220)	θ value	θ > 10 (rank : 1808)
Query Neighborhood Hits	1762	Target Neighborhood Hits	54	Shared Neighborhood Hits	42
SwissProt Accessions	Q6PCB8	Gene names	EMB
Domain Architecture	No domain graphic available
Description	Embigin precursor.

WASIP_MOUSE
NC score	0.066804 (rank : 1221)	θ value	θ > 10 (rank : 1939)
Query Neighborhood Hits	1762	Target Neighborhood Hits	392	Shared Neighborhood Hits	212
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

RGS3_MOUSE
NC score	0.066794 (rank : 1222)	θ value	2.44474e-05 (rank : 811)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1621	Shared Neighborhood Hits	444
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

CHIN_HUMAN
NC score	0.066645 (rank : 1223)	θ value	θ > 10 (rank : 1784)
Query Neighborhood Hits	1762	Target Neighborhood Hits	227	Shared Neighborhood Hits	66
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

DCX_MOUSE
NC score	0.066555 (rank : 1224)	θ value	θ > 10 (rank : 1802)
Query Neighborhood Hits	1762	Target Neighborhood Hits	124	Shared Neighborhood Hits	47
SwissProt Accessions	O88809	Gene names	Dcx, Dcn
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

UN13B_MOUSE
NC score	0.066456 (rank : 1225)	θ value	θ > 10 (rank : 1930)
Query Neighborhood Hits	1762	Target Neighborhood Hits	210	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

PACE1_HUMAN
NC score	0.066265 (rank : 1226)	θ value	θ > 10 (rank : 1866)
Query Neighborhood Hits	1762	Target Neighborhood Hits	74	Shared Neighborhood Hits	50
SwissProt Accessions	Q8IZE3, Q5THA6, Q5THA8, Q8IZN9, Q96C56, Q9UBK6	Gene names	SCYL3, PACE1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

IGSF2_HUMAN
NC score	0.066181 (rank : 1227)	θ value	θ > 10 (rank : 1835)
Query Neighborhood Hits	1762	Target Neighborhood Hits	208	Shared Neighborhood Hits	92
SwissProt Accessions	Q93033, Q15856	Gene names	IGSF2, CD101, EWI101, V7
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 2 precursor (Glu-Trp-Ile EWI motif- containing protein 101) (EWI-101) (Cell surface glycoprotein V7) (CD101 antigen).

CN155_HUMAN
NC score	0.066089 (rank : 1228)	θ value	θ > 10 (rank : 1788)
Query Neighborhood Hits	1762	Target Neighborhood Hits	385	Shared Neighborhood Hits	167
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

SIGL9_HUMAN
NC score	0.066012 (rank : 1229)	θ value	θ > 10 (rank : 1907)
Query Neighborhood Hits	1762	Target Neighborhood Hits	76	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y336, Q9BYI9	Gene names	SIGLEC9
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 9 precursor (Siglec-9) (Protein FOAP-9).

TENN_HUMAN
NC score	0.065598 (rank : 1230)	θ value	5.27518 (rank : 1594)
Query Neighborhood Hits	1762	Target Neighborhood Hits	453	Shared Neighborhood Hits	117
SwissProt Accessions	Q9UQP3, Q5R360	Gene names	TNN
Domain Architecture
Description	Tenascin-N precursor (TN-N).

FCGR1_MOUSE
NC score	0.065269 (rank : 1231)	θ value	θ > 10 (rank : 1814)
Query Neighborhood Hits	1762	Target Neighborhood Hits	123	Shared Neighborhood Hits	86
SwissProt Accessions	P26151	Gene names	Fcgr1, Fcg1
Domain Architecture
Description	High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma RI) (FcRI) (IgG Fc receptor I).

SH21B_MOUSE
NC score	0.064479 (rank : 1232)	θ value	θ > 10 (rank : 1905)
Query Neighborhood Hits	1762	Target Neighborhood Hits	101	Shared Neighborhood Hits	40
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

COKA1_HUMAN
NC score	0.064338 (rank : 1233)	θ value	θ > 10 (rank : 1794)
Query Neighborhood Hits	1762	Target Neighborhood Hits	403	Shared Neighborhood Hits	150
SwissProt Accessions	Q9P218, Q4VXQ4, Q8WUT2, Q96CY9, Q9BQU6, Q9BQU7	Gene names	COL20A1, KIAA1510
Domain Architecture
Description	Collagen alpha-1(XX) chain precursor.

CT075_HUMAN
NC score	0.064331 (rank : 1234)	θ value	θ > 10 (rank : 1797)
Query Neighborhood Hits	1762	Target Neighborhood Hits	387	Shared Neighborhood Hits	118
SwissProt Accessions	Q8WUT4, Q5JWV6, Q9H419	Gene names	C20orf75
Domain Architecture
Description	Uncharacterized protein C20orf75 precursor.

SHPS1_HUMAN
NC score	0.064057 (rank : 1235)	θ value	θ > 10 (rank : 1906)
Query Neighborhood Hits	1762	Target Neighborhood Hits	455	Shared Neighborhood Hits	105
SwissProt Accessions	P78324, O00683, O43799, Q8N517, Q8TAL8, Q9H0Z2, Q9UDX2, Q9UIJ6, Q9Y4U9	Gene names	SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (Sirp-alpha-2) (Sirp-alpha- 3) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (Macrophage fusion receptor) (p84) (CD172a antigen).

FPRP_HUMAN
NC score	0.063949 (rank : 1236)	θ value	θ > 10 (rank : 1817)
Query Neighborhood Hits	1762	Target Neighborhood Hits	130	Shared Neighborhood Hits	84
SwissProt Accessions	Q9P2B2, Q8N2K6	Gene names	PTGFRN, CD9P1, FPRP, KIAA1436
Domain Architecture
Description	Prostaglandin F2 receptor negative regulator precursor (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD9 partner 1) (CD9P-1) (CD315 antigen).

WASL_HUMAN
NC score	0.063332 (rank : 1237)	θ value	3.0926 (rank : 1488)
Query Neighborhood Hits	1762	Target Neighborhood Hits	312	Shared Neighborhood Hits	189
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

DGKH_HUMAN
NC score	0.063254 (rank : 1238)	θ value	θ > 10 (rank : 1805)
Query Neighborhood Hits	1762	Target Neighborhood Hits	255	Shared Neighborhood Hits	74
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

DGKQ_HUMAN
NC score	0.062923 (rank : 1239)	θ value	θ > 10 (rank : 1807)
Query Neighborhood Hits	1762	Target Neighborhood Hits	131	Shared Neighborhood Hits	39
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

NCOA6_MOUSE
NC score	0.062708 (rank : 1240)	θ value	0.163984 (rank : 1112)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1076	Shared Neighborhood Hits	328
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

ANKF1_HUMAN
NC score	0.062608 (rank : 1241)	θ value	θ > 10 (rank : 1765)
Query Neighborhood Hits	1762	Target Neighborhood Hits	126	Shared Neighborhood Hits	52
SwissProt Accessions	Q8N957	Gene names	ANKFN1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and fibronectin type-III domain-containing protein 1.

SIGIR_MOUSE
NC score	0.062136 (rank : 1242)	θ value	0.125558 (rank : 1098)
Query Neighborhood Hits	1762	Target Neighborhood Hits	95	Shared Neighborhood Hits	61
SwissProt Accessions	Q9JLZ8, Q52L48	Gene names	Sigirr, Tir8
Domain Architecture	No domain graphic available
Description	Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8).

CSF3R_MOUSE
NC score	0.061460 (rank : 1243)	θ value	θ > 10 (rank : 1796)
Query Neighborhood Hits	1762	Target Neighborhood Hits	104	Shared Neighborhood Hits	57
SwissProt Accessions	P40223	Gene names	Csf3r, Csfgr
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

CHIO_MOUSE
NC score	0.061201 (rank : 1244)	θ value	θ > 10 (rank : 1787)
Query Neighborhood Hits	1762	Target Neighborhood Hits	130	Shared Neighborhood Hits	38
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

ALEX_HUMAN
NC score	0.061012 (rank : 1245)	θ value	2.36792 (rank : 1389)
Query Neighborhood Hits	1762	Target Neighborhood Hits	361	Shared Neighborhood Hits	160
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

ENAH_MOUSE
NC score	0.060939 (rank : 1246)	θ value	5.27518 (rank : 1559)
Query Neighborhood Hits	1762	Target Neighborhood Hits	919	Shared Neighborhood Hits	271
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

MBD6_HUMAN
NC score	0.060731 (rank : 1247)	θ value	θ > 10 (rank : 1853)
Query Neighborhood Hits	1762	Target Neighborhood Hits	349	Shared Neighborhood Hits	161
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

CD4_HUMAN
NC score	0.060411 (rank : 1248)	θ value	θ > 10 (rank : 1778)
Query Neighborhood Hits	1762	Target Neighborhood Hits	122	Shared Neighborhood Hits	55
SwissProt Accessions	P01730, Q4ZGK2, Q5U066	Gene names	CD4
Domain Architecture
Description	T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3).

CJ078_MOUSE
NC score	0.060339 (rank : 1249)	θ value	8.99809 (rank : 1681)
Query Neighborhood Hits	1762	Target Neighborhood Hits	559	Shared Neighborhood Hits	204
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

RASF1_HUMAN
NC score	0.060311 (rank : 1250)	θ value	θ > 10 (rank : 1895)
Query Neighborhood Hits	1762	Target Neighborhood Hits	62	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NS23, O14571, O60539, O60710, Q9HB04, Q9HB18, Q9NS22, Q9UND4, Q9UND5	Gene names	RASSF1, RDA32
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1.

TENX_HUMAN
NC score	0.060260 (rank : 1251)	θ value	1.38821 (rank : 1344)
Query Neighborhood Hits	1762	Target Neighborhood Hits	789	Shared Neighborhood Hits	174
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

MUC1_HUMAN
NC score	0.060030 (rank : 1252)	θ value	5.81887e-07 (rank : 730)
Query Neighborhood Hits	1762	Target Neighborhood Hits	975	Shared Neighborhood Hits	301
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

RGS3_HUMAN
NC score	0.059704 (rank : 1253)	θ value	0.00869519 (rank : 986)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1375	Shared Neighborhood Hits	349
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

CIC_HUMAN
NC score	0.059620 (rank : 1254)	θ value	0.00134147 (rank : 917)
Query Neighborhood Hits	1762	Target Neighborhood Hits	992	Shared Neighborhood Hits	340
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

FPRP_MOUSE
NC score	0.059551 (rank : 1255)	θ value	θ > 10 (rank : 1818)
Query Neighborhood Hits	1762	Target Neighborhood Hits	116	Shared Neighborhood Hits	66
SwissProt Accessions	Q9WV91	Gene names	Ptgfrn, Fprp
Domain Architecture
Description	Prostaglandin F2 receptor negative regulator precursor (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD315 antigen).

TARA_HUMAN
NC score	0.059462 (rank : 1256)	θ value	0.0252991 (rank : 1020)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1626	Shared Neighborhood Hits	368
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

WASL_MOUSE
NC score	0.059398 (rank : 1257)	θ value	θ > 10 (rank : 1940)
Query Neighborhood Hits	1762	Target Neighborhood Hits	339	Shared Neighborhood Hits	189
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

I12R1_HUMAN
NC score	0.059385 (rank : 1258)	θ value	θ > 10 (rank : 1828)
Query Neighborhood Hits	1762	Target Neighborhood Hits	78	Shared Neighborhood Hits	51
SwissProt Accessions	P42701	Gene names	IL12RB1, IL12R, IL12RB
Domain Architecture
Description	Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component) (IL- 12RB1) (CD212 antigen).

RASA1_HUMAN
NC score	0.059192 (rank : 1259)	θ value	θ > 10 (rank : 1894)
Query Neighborhood Hits	1762	Target Neighborhood Hits	258	Shared Neighborhood Hits	69
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

SH21B_HUMAN
NC score	0.058756 (rank : 1260)	θ value	θ > 10 (rank : 1904)
Query Neighborhood Hits	1762	Target Neighborhood Hits	101	Shared Neighborhood Hits	41
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

CS016_HUMAN
NC score	0.058641 (rank : 1261)	θ value	1.81305 (rank : 1358)
Query Neighborhood Hits	1762	Target Neighborhood Hits	310	Shared Neighborhood Hits	148
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

LCP2_HUMAN
NC score	0.058529 (rank : 1262)	θ value	θ > 10 (rank : 1849)
Query Neighborhood Hits	1762	Target Neighborhood Hits	531	Shared Neighborhood Hits	192
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

SH21A_MOUSE
NC score	0.058449 (rank : 1263)	θ value	θ > 10 (rank : 1903)
Query Neighborhood Hits	1762	Target Neighborhood Hits	89	Shared Neighborhood Hits	40
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

IASPP_MOUSE
NC score	0.058290 (rank : 1264)	θ value	0.00869519 (rank : 982)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1024	Shared Neighborhood Hits	300
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

NFH_MOUSE
NC score	0.058178 (rank : 1265)	θ value	2.13673e-09 (rank : 603)
Query Neighborhood Hits	1762	Target Neighborhood Hits	2247	Shared Neighborhood Hits	476
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

SFPQ_HUMAN
NC score	0.058144 (rank : 1266)	θ value	0.163984 (rank : 1115)
Query Neighborhood Hits	1762	Target Neighborhood Hits	986	Shared Neighborhood Hits	273
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

MADCA_HUMAN
NC score	0.058139 (rank : 1267)	θ value	θ > 10 (rank : 1852)
Query Neighborhood Hits	1762	Target Neighborhood Hits	221	Shared Neighborhood Hits	121
SwissProt Accessions	Q13477, O60222, O75867	Gene names	MADCAM1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (hMAdCAM-1).

MARCS_HUMAN
NC score	0.058075 (rank : 1268)	θ value	6.88961 (rank : 1627)
Query Neighborhood Hits	1762	Target Neighborhood Hits	204	Shared Neighborhood Hits	98
SwissProt Accessions	P29966, Q2LA83, Q5TDB7	Gene names	MARCKS, MACS, PRKCSL
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (PKCSL) (80K-L protein).

YLPM1_MOUSE
NC score	0.058035 (rank : 1269)	θ value	4.03905 (rank : 1536)
Query Neighborhood Hits	1762	Target Neighborhood Hits	505	Shared Neighborhood Hits	207
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

BAT2_MOUSE
NC score	0.058007 (rank : 1270)	θ value	3.0926 (rank : 1448)
Query Neighborhood Hits	1762	Target Neighborhood Hits	947	Shared Neighborhood Hits	338
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

SET1A_HUMAN
NC score	0.057992 (rank : 1271)	θ value	0.47712 (rank : 1187)
Query Neighborhood Hits	1762	Target Neighborhood Hits	690	Shared Neighborhood Hits	235
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

TXND2_HUMAN
NC score	0.057865 (rank : 1272)	θ value	0.000786445 (rank : 905)
Query Neighborhood Hits	1762	Target Neighborhood Hits	793	Shared Neighborhood Hits	216
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

DGKK_HUMAN
NC score	0.057243 (rank : 1273)	θ value	θ > 10 (rank : 1806)
Query Neighborhood Hits	1762	Target Neighborhood Hits	378	Shared Neighborhood Hits	182
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

SELPL_MOUSE
NC score	0.057215 (rank : 1274)	θ value	0.0736092 (rank : 1067)
Query Neighborhood Hits	1762	Target Neighborhood Hits	588	Shared Neighborhood Hits	208
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

AMGO2_HUMAN
NC score	0.056791 (rank : 1275)	θ value	6.88961 (rank : 1599)
Query Neighborhood Hits	1762	Target Neighborhood Hits	357	Shared Neighborhood Hits	134
SwissProt Accessions	Q86SJ2, Q7Z4A0, Q96CN8	Gene names	AMIGO2, ALI1
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 2 precursor (AMIGO-2) (Alivin-1) (Differentially expressed in gastric adenocarcinomas) (DEGA).

RIMB2_HUMAN
NC score	0.056717 (rank : 1276)	θ value	θ > 10 (rank : 1898)
Query Neighborhood Hits	1762	Target Neighborhood Hits	263	Shared Neighborhood Hits	91
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

WIRE_HUMAN
NC score	0.056453 (rank : 1277)	θ value	θ > 10 (rank : 1941)
Query Neighborhood Hits	1762	Target Neighborhood Hits	329	Shared Neighborhood Hits	172
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

A1BG_HUMAN
NC score	0.056099 (rank : 1278)	θ value	0.0961366 (rank : 1071)
Query Neighborhood Hits	1762	Target Neighborhood Hits	94	Shared Neighborhood Hits	42
SwissProt Accessions	P04217, Q8IYJ6, Q96P39	Gene names	A1BG
Domain Architecture
Description	Alpha-1B-glycoprotein precursor (Alpha-1-B glycoprotein).

SPR1B_MOUSE
NC score	0.055990 (rank : 1279)	θ value	4.1701e-05 (rank : 823)
Query Neighborhood Hits	1762	Target Neighborhood Hits	395	Shared Neighborhood Hits	138
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

GRIN1_HUMAN
NC score	0.055942 (rank : 1280)	θ value	0.0252991 (rank : 1014)
Query Neighborhood Hits	1762	Target Neighborhood Hits	681	Shared Neighborhood Hits	234
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

FA47B_HUMAN
NC score	0.055568 (rank : 1281)	θ value	2.44474e-05 (rank : 806)
Query Neighborhood Hits	1762	Target Neighborhood Hits	431	Shared Neighborhood Hits	147
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

MOX2R_HUMAN
NC score	0.055510 (rank : 1282)	θ value	θ > 10 (rank : 1857)
Query Neighborhood Hits	1762	Target Neighborhood Hits	51	Shared Neighborhood Hits	39
SwissProt Accessions	Q8TD46, Q8TD44, Q8TD45, Q8TD52	Gene names	CD200R1, CD200R, CRTR2, MOX2R, OX2R
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor).

MARCS_MOUSE
NC score	0.055476 (rank : 1283)	θ value	2.36792 (rank : 1421)
Query Neighborhood Hits	1762	Target Neighborhood Hits	227	Shared Neighborhood Hits	103
SwissProt Accessions	P26645	Gene names	Marcks, Macs
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS).

FA47A_HUMAN
NC score	0.055245 (rank : 1284)	θ value	0.0330416 (rank : 1027)
Query Neighborhood Hits	1762	Target Neighborhood Hits	451	Shared Neighborhood Hits	165
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

RP1L1_HUMAN
NC score	0.055241 (rank : 1285)	θ value	1.06291 (rank : 1283)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1072	Shared Neighborhood Hits	252
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

BTNL2_HUMAN
NC score	0.055056 (rank : 1286)	θ value	θ > 10 (rank : 1773)
Query Neighborhood Hits	1762	Target Neighborhood Hits	164	Shared Neighborhood Hits	92
SwissProt Accessions	Q9UIR0, O98261, Q5JYF9, Q5RIF8, Q5SP08, Q5SP09, Q5SRW3, Q5SRW4, Q5SU36, Q95HK0	Gene names	BTNL2
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 2 precursor (BTL-II).

MLL2_HUMAN
NC score	0.054923 (rank : 1287)	θ value	6.88961 (rank : 1632)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1788	Shared Neighborhood Hits	435
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

SIRB1_HUMAN
NC score	0.054814 (rank : 1288)	θ value	θ > 10 (rank : 1908)
Query Neighborhood Hits	1762	Target Neighborhood Hits	422	Shared Neighborhood Hits	96
SwissProt Accessions	O00241, Q5TFR0, Q8TB12, Q9H1U5, Q9Y4V0	Gene names	SIRPB1
Domain Architecture
Description	Signal-regulatory protein beta-1 precursor (SIRP-beta-1) (CD172b antigen).

SON_MOUSE
NC score	0.054767 (rank : 1289)	θ value	1.38821 (rank : 1340)
Query Neighborhood Hits	1762	Target Neighborhood Hits	957	Shared Neighborhood Hits	278
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

CK024_HUMAN
NC score	0.054703 (rank : 1290)	θ value	1.81305 (rank : 1356)
Query Neighborhood Hits	1762	Target Neighborhood Hits	408	Shared Neighborhood Hits	182
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

FCRLA_MOUSE
NC score	0.054645 (rank : 1291)	θ value	6.88961 (rank : 1617)
Query Neighborhood Hits	1762	Target Neighborhood Hits	110	Shared Neighborhood Hits	58
SwissProt Accessions	Q920A9, Q3T9Q2, Q8K3U9, Q8VHP5	Gene names	Fcrla, Fcrl, Fcrl1, Fcrlm1, Fcrx, Freb
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

MAGE1_HUMAN
NC score	0.054332 (rank : 1292)	θ value	9.29e-05 (rank : 844)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1389	Shared Neighborhood Hits	402
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

ATN1_HUMAN
NC score	0.054328 (rank : 1293)	θ value	θ > 10 (rank : 1770)
Query Neighborhood Hits	1762	Target Neighborhood Hits	676	Shared Neighborhood Hits	237
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

RAPH1_HUMAN
NC score	0.054118 (rank : 1294)	θ value	6.88961 (rank : 1647)
Query Neighborhood Hits	1762	Target Neighborhood Hits	593	Shared Neighborhood Hits	246
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

TGON2_HUMAN
NC score	0.053561 (rank : 1295)	θ value	0.163984 (rank : 1117)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1037	Shared Neighborhood Hits	256
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

TCOF_MOUSE
NC score	0.053282 (rank : 1296)	θ value	8.99809 (rank : 1752)
Query Neighborhood Hits	1762	Target Neighborhood Hits	471	Shared Neighborhood Hits	152
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

YLPM1_HUMAN
NC score	0.053249 (rank : 1297)	θ value	2.36792 (rank : 1442)
Query Neighborhood Hits	1762	Target Neighborhood Hits	670	Shared Neighborhood Hits	250
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

NOLC1_HUMAN
NC score	0.053087 (rank : 1298)	θ value	1.38821 (rank : 1325)
Query Neighborhood Hits	1762	Target Neighborhood Hits	452	Shared Neighborhood Hits	137
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

PCQAP_HUMAN
NC score	0.053072 (rank : 1299)	θ value	θ > 10 (rank : 1868)
Query Neighborhood Hits	1762	Target Neighborhood Hits	549	Shared Neighborhood Hits	175
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

SH21A_HUMAN
NC score	0.053037 (rank : 1300)	θ value	θ > 10 (rank : 1902)
Query Neighborhood Hits	1762	Target Neighborhood Hits	89	Shared Neighborhood Hits	38
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

FCG2B_HUMAN
NC score	0.052983 (rank : 1301)	θ value	θ > 10 (rank : 1811)
Query Neighborhood Hits	1762	Target Neighborhood Hits	116	Shared Neighborhood Hits	73
SwissProt Accessions	P31994, O95649, Q53X85, Q5VXA9, Q8NIA1	Gene names	FCGR2B, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-b precursor (Fc-gamma RII-b) (FcRII-b) (IgG Fc receptor II-b) (Fc-gamma-RIIb) (CD32 antigen) (CDw32).

RIMB2_MOUSE
NC score	0.052722 (rank : 1302)	θ value	θ > 10 (rank : 1899)
Query Neighborhood Hits	1762	Target Neighborhood Hits	246	Shared Neighborhood Hits	76
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

FCG2C_HUMAN
NC score	0.052646 (rank : 1303)	θ value	θ > 10 (rank : 1812)
Query Neighborhood Hits	1762	Target Neighborhood Hits	118	Shared Neighborhood Hits	75
SwissProt Accessions	P31995, O00523, O00524, O00525	Gene names	FCGR2C, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-c precursor (Fc-gamma RII-c) (FcRII-c) (IgG Fc receptor II-c) (Fc-gamma-RIIc) (CD32 antigen) (CDw32).

MAP4_MOUSE
NC score	0.052513 (rank : 1304)	θ value	0.47712 (rank : 1177)
Query Neighborhood Hits	1762	Target Neighborhood Hits	409	Shared Neighborhood Hits	164
SwissProt Accessions	P27546	Gene names	Map4, Mtap4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

GGN_MOUSE
NC score	0.052303 (rank : 1305)	θ value	6.88961 (rank : 1620)
Query Neighborhood Hits	1762	Target Neighborhood Hits	311	Shared Neighborhood Hits	160
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

CO039_MOUSE
NC score	0.051534 (rank : 1306)	θ value	0.00665767 (rank : 965)
Query Neighborhood Hits	1762	Target Neighborhood Hits	445	Shared Neighborhood Hits	178
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

MINT_MOUSE
NC score	0.051494 (rank : 1307)	θ value	0.0961366 (rank : 1077)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1514	Shared Neighborhood Hits	357
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

GGN_HUMAN
NC score	0.050925 (rank : 1308)	θ value	θ > 10 (rank : 1819)
Query Neighborhood Hits	1762	Target Neighborhood Hits	269	Shared Neighborhood Hits	146
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

NCOR2_HUMAN
NC score	0.050905 (rank : 1309)	θ value	θ > 10 (rank : 1862)
Query Neighborhood Hits	1762	Target Neighborhood Hits	870	Shared Neighborhood Hits	263
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

JAML1_HUMAN
NC score	0.050881 (rank : 1310)	θ value	θ > 10 (rank : 1846)
Query Neighborhood Hits	1762	Target Neighborhood Hits	108	Shared Neighborhood Hits	53
SwissProt Accessions	Q86YT9, Q5DTC6, Q7Z499, Q8N9I7, Q8NF70	Gene names	AMICA1, JAML
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule-like precursor (Dendritic cell-specific protein CREA7-1) (Adhesion molecule interacting with CXADR antigen 1).

WIRE_MOUSE
NC score	0.050722 (rank : 1311)	θ value	θ > 10 (rank : 1942)
Query Neighborhood Hits	1762	Target Neighborhood Hits	310	Shared Neighborhood Hits	166
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

CO039_HUMAN
NC score	0.050694 (rank : 1312)	θ value	0.21417 (rank : 1122)
Query Neighborhood Hits	1762	Target Neighborhood Hits	264	Shared Neighborhood Hits	123
SwissProt Accessions	Q6ZRI6, Q71JB1, Q7L3S0, Q8N3F2, Q96FB6, Q9NTU5	Gene names	C15orf39
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39.

K1683_HUMAN
NC score	0.050628 (rank : 1313)	θ value	0.00102713 (rank : 910)
Query Neighborhood Hits	1762	Target Neighborhood Hits	240	Shared Neighborhood Hits	94
SwissProt Accessions	Q9H0B3, Q8N4G8, Q96M14, Q9C0I0	Gene names	KIAA1683
Domain Architecture	No domain graphic available
Description	Protein KIAA1683.

PELP1_MOUSE
NC score	0.050603 (rank : 1314)	θ value	0.0431538 (rank : 1047)
Query Neighborhood Hits	1762	Target Neighborhood Hits	709	Shared Neighborhood Hits	213
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

DAPP1_HUMAN
NC score	0.050565 (rank : 1315)	θ value	θ > 10 (rank : 1800)
Query Neighborhood Hits	1762	Target Neighborhood Hits	227	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

LAD1_MOUSE
NC score	0.050505 (rank : 1316)	θ value	1.06291 (rank : 1272)
Query Neighborhood Hits	1762	Target Neighborhood Hits	391	Shared Neighborhood Hits	128
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

PI5PA_HUMAN
NC score	0.050494 (rank : 1317)	θ value	0.47712 (rank : 1183)
Query Neighborhood Hits	1762	Target Neighborhood Hits	749	Shared Neighborhood Hits	266
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

DGKB_HUMAN
NC score	0.050301 (rank : 1318)	θ value	θ > 10 (rank : 1803)
Query Neighborhood Hits	1762	Target Neighborhood Hits	238	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y6T7, O75241, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29	Gene names	DGKB, DAGK2, KIAA0718
Domain Architecture
Description	Diacylglycerol kinase beta (EC 2.7.1.107) (Diglyceride kinase beta) (DGK-beta) (DAG kinase beta) (90 kDa diacylglycerol kinase).

RERE_HUMAN
NC score	0.050220 (rank : 1319)	θ value	θ > 10 (rank : 1897)
Query Neighborhood Hits	1762	Target Neighborhood Hits	779	Shared Neighborhood Hits	266
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

SFPQ_MOUSE
NC score	0.050200 (rank : 1320)	θ value	θ > 10 (rank : 1901)
Query Neighborhood Hits	1762	Target Neighborhood Hits	958	Shared Neighborhood Hits	259
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

TENA_HUMAN
NC score	0.050110 (rank : 1321)	θ value	θ > 10 (rank : 1920)
Query Neighborhood Hits	1762	Target Neighborhood Hits	631	Shared Neighborhood Hits	136
SwissProt Accessions	P24821, Q14583, Q15567	Gene names	TNC, HXB
Domain Architecture
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Myotendinous antigen) (Glioma- associated-extracellular matrix antigen) (GP 150-225).

SYN1_HUMAN
NC score	0.050074 (rank : 1322)	θ value	6.88961 (rank : 1655)
Query Neighborhood Hits	1762	Target Neighborhood Hits	419	Shared Neighborhood Hits	217
SwissProt Accessions	P17600, O75825, Q5H9A9	Gene names	SYN1
Domain Architecture
Description	Synapsin-1 (Synapsin I) (Brain protein 4.1).

CBP_HUMAN
NC score	0.049630 (rank : 1323)	θ value	0.0563607 (rank : 1054)
Query Neighborhood Hits	1762	Target Neighborhood Hits	941	Shared Neighborhood Hits	301
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

RIMB1_HUMAN
NC score	0.049339 (rank : 1324)	θ value	0.0431538 (rank : 1049)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1479	Shared Neighborhood Hits	301
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

MAP4_HUMAN
NC score	0.049098 (rank : 1325)	θ value	0.125558 (rank : 1096)
Query Neighborhood Hits	1762	Target Neighborhood Hits	428	Shared Neighborhood Hits	149
SwissProt Accessions	P27816, Q13082, Q96A76	Gene names	MAP4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

MBB1A_HUMAN
NC score	0.048864 (rank : 1326)	θ value	0.0431538 (rank : 1045)
Query Neighborhood Hits	1762	Target Neighborhood Hits	665	Shared Neighborhood Hits	202
SwissProt Accessions	Q9BQG0, Q86VM3, Q9BW49, Q9P0V5, Q9UF99	Gene names	MYBBP1A, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A.

IASPP_HUMAN
NC score	0.048836 (rank : 1327)	θ value	1.06291 (rank : 1268)
Query Neighborhood Hits	1762	Target Neighborhood Hits	688	Shared Neighborhood Hits	201
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

CBP_MOUSE
NC score	0.048448 (rank : 1328)	θ value	0.0563607 (rank : 1055)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1051	Shared Neighborhood Hits	320
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

PELP1_HUMAN
NC score	0.048241 (rank : 1329)	θ value	0.0431538 (rank : 1046)
Query Neighborhood Hits	1762	Target Neighborhood Hits	596	Shared Neighborhood Hits	171
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

MUC2_HUMAN
NC score	0.048233 (rank : 1330)	θ value	3.0926 (rank : 1473)
Query Neighborhood Hits	1762	Target Neighborhood Hits	906	Shared Neighborhood Hits	277
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

LR37A_HUMAN
NC score	0.048205 (rank : 1331)	θ value	4.03905 (rank : 1516)
Query Neighborhood Hits	1762	Target Neighborhood Hits	720	Shared Neighborhood Hits	222
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

MAP1A_HUMAN
NC score	0.047931 (rank : 1332)	θ value	0.47712 (rank : 1176)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1626	Shared Neighborhood Hits	322
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

TCOF_HUMAN
NC score	0.047878 (rank : 1333)	θ value	5.27518 (rank : 1593)
Query Neighborhood Hits	1762	Target Neighborhood Hits	543	Shared Neighborhood Hits	163
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

SPR1A_MOUSE
NC score	0.047760 (rank : 1334)	θ value	4.1701e-05 (rank : 822)
Query Neighborhood Hits	1762	Target Neighborhood Hits	343	Shared Neighborhood Hits	108
SwissProt Accessions	Q62266	Gene names	Sprr1a
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein 1A) (SPR1A) (SPR1 A).

SAPS1_HUMAN
NC score	0.047577 (rank : 1335)	θ value	0.00509761 (rank : 961)
Query Neighborhood Hits	1762	Target Neighborhood Hits	704	Shared Neighborhood Hits	239
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

SF01_HUMAN
NC score	0.047502 (rank : 1336)	θ value	4.03905 (rank : 1527)
Query Neighborhood Hits	1762	Target Neighborhood Hits	287	Shared Neighborhood Hits	146
SwissProt Accessions	Q15637, Q14818, Q14819, Q15913, Q8IY00, Q92744, Q92745, Q969H7, Q9BW01, Q9UEI0	Gene names	SF1, ZFM1, ZNF162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Mammalian branch point-binding protein mBBP) (BBP).

ASPP1_MOUSE
NC score	0.047385 (rank : 1337)	θ value	5.27518 (rank : 1544)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1244	Shared Neighborhood Hits	283
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

SYN1_MOUSE
NC score	0.047259 (rank : 1338)	θ value	8.99809 (rank : 1751)
Query Neighborhood Hits	1762	Target Neighborhood Hits	363	Shared Neighborhood Hits	193
SwissProt Accessions	O88935, Q62279, Q8QZT8	Gene names	Syn1, Syn-1
Domain Architecture
Description	Synapsin-1 (Synapsin I).

CIC_MOUSE
NC score	0.046826 (rank : 1339)	θ value	0.125558 (rank : 1087)
Query Neighborhood Hits	1762	Target Neighborhood Hits	742	Shared Neighborhood Hits	289
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

SPRR3_HUMAN
NC score	0.046753 (rank : 1340)	θ value	1.38821 (rank : 1342)
Query Neighborhood Hits	1762	Target Neighborhood Hits	102	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UBC9, O75597, Q4ZGI7, Q5T525, Q8NET7, Q9UDG3	Gene names	SPRR3, SPRC
Domain Architecture
Description	Small proline-rich protein 3 (Cornifin beta) (Esophagin) (22 kDa pancornulin).

CSKI1_HUMAN
NC score	0.046709 (rank : 1341)	θ value	8.99809 (rank : 1685)
Query Neighborhood Hits	1762	Target Neighborhood Hits	997	Shared Neighborhood Hits	318
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

NU214_HUMAN
NC score	0.046009 (rank : 1342)	θ value	1.06291 (rank : 1279)
Query Neighborhood Hits	1762	Target Neighborhood Hits	657	Shared Neighborhood Hits	181
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

I11RA_HUMAN
NC score	0.045559 (rank : 1343)	θ value	2.36792 (rank : 1415)
Query Neighborhood Hits	1762	Target Neighborhood Hits	138	Shared Neighborhood Hits	56
SwissProt Accessions	Q14626, Q16542, Q7KYJ7	Gene names	IL11RA
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha chain precursor (IL-11R-alpha) (IL- 11RA).

CNOT3_HUMAN
NC score	0.045444 (rank : 1344)	θ value	4.03905 (rank : 1497)
Query Neighborhood Hits	1762	Target Neighborhood Hits	425	Shared Neighborhood Hits	134
SwissProt Accessions	O75175, Q9NZN7, Q9UF76	Gene names	CNOT3, KIAA0691, NOT3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

AMGO3_HUMAN
NC score	0.045022 (rank : 1345)	θ value	8.99809 (rank : 1669)
Query Neighborhood Hits	1762	Target Neighborhood Hits	276	Shared Neighborhood Hits	83
SwissProt Accessions	Q86WK7, Q96JH6	Gene names	AMIGO3, ALI3, KIAA1851
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 3 precursor (AMIGO-3) (Alivin-3).

SYNJ1_MOUSE
NC score	0.044629 (rank : 1346)	θ value	5.27518 (rank : 1592)
Query Neighborhood Hits	1762	Target Neighborhood Hits	516	Shared Neighborhood Hits	228
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

K1543_HUMAN
NC score	0.044424 (rank : 1347)	θ value	0.813845 (rank : 1235)
Query Neighborhood Hits	1762	Target Neighborhood Hits	435	Shared Neighborhood Hits	172
SwissProt Accessions	Q9P1Y5, Q8NDF1	Gene names	KIAA1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

SPR1A_HUMAN
NC score	0.044005 (rank : 1348)	θ value	0.00298849 (rank : 946)
Query Neighborhood Hits	1762	Target Neighborhood Hits	136	Shared Neighborhood Hits	38
SwissProt Accessions	P35321, Q9UDG4	Gene names	SPRR1A
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein IA) (SPR-IA) (SPRK) (19 kDa pancornulin).

TAU_HUMAN
NC score	0.043907 (rank : 1349)	θ value	2.36792 (rank : 1438)
Query Neighborhood Hits	1762	Target Neighborhood Hits	448	Shared Neighborhood Hits	172
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

MINT_HUMAN
NC score	0.043676 (rank : 1350)	θ value	6.88961 (rank : 1630)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1291	Shared Neighborhood Hits	305
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

IGSF8_HUMAN
NC score	0.043543 (rank : 1351)	θ value	3.0926 (rank : 1465)
Query Neighborhood Hits	1762	Target Neighborhood Hits	88	Shared Neighborhood Hits	40
SwissProt Accessions	Q969P0, Q8NG09, Q96DP4, Q9BTG9	Gene names	IGSF8, CD81P3, EWI2, KCT4
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 8 precursor (CD81 partner 3) (Glu- Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes- associated transmembrane protein 4) (KCT-4) (LIR-D1) (CD316 antigen).

FYB_HUMAN
NC score	0.043319 (rank : 1352)	θ value	0.0148317 (rank : 1001)
Query Neighborhood Hits	1762	Target Neighborhood Hits	379	Shared Neighborhood Hits	124
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

PO121_MOUSE
NC score	0.043210 (rank : 1353)	θ value	4.03905 (rank : 1521)
Query Neighborhood Hits	1762	Target Neighborhood Hits	345	Shared Neighborhood Hits	143
SwissProt Accessions	Q8K3Z9, Q7TSH5	Gene names	Pom121, Nup121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa).

T22D4_HUMAN
NC score	0.043049 (rank : 1354)	θ value	0.47712 (rank : 1189)
Query Neighborhood Hits	1762	Target Neighborhood Hits	403	Shared Neighborhood Hits	149
SwissProt Accessions	Q9Y3Q8	Gene names	TSC22D4, TILZ2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1).

EFS_HUMAN
NC score	0.043017 (rank : 1355)	θ value	1.38821 (rank : 1305)
Query Neighborhood Hits	1762	Target Neighborhood Hits	348	Shared Neighborhood Hits	137
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

TP53B_MOUSE
NC score	0.042794 (rank : 1356)	θ value	0.0736092 (rank : 1069)
Query Neighborhood Hits	1762	Target Neighborhood Hits	644	Shared Neighborhood Hits	169
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

CASC3_MOUSE
NC score	0.042675 (rank : 1357)	θ value	0.00390308 (rank : 950)
Query Neighborhood Hits	1762	Target Neighborhood Hits	333	Shared Neighborhood Hits	118
SwissProt Accessions	Q8K3W3, Q8K219, Q99NF0	Gene names	Casc3, Mln51
Domain Architecture	No domain graphic available
Description	Protein CASC3 (Cancer susceptibility candidate gene 3 protein homolog) (Metastatic lymph node protein 51 homolog) (Protein MLN 51 homolog) (Protein barentsz) (Btz).

NIPBL_HUMAN
NC score	0.042668 (rank : 1358)	θ value	0.00102713 (rank : 915)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1311	Shared Neighborhood Hits	243
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

RTP3_MOUSE
NC score	0.042451 (rank : 1359)	θ value	0.0563607 (rank : 1061)
Query Neighborhood Hits	1762	Target Neighborhood Hits	374	Shared Neighborhood Hits	133
SwissProt Accessions	Q5QGU6, Q8VDC2	Gene names	Rtp3, Tmem7
Domain Architecture	No domain graphic available
Description	Receptor-transporting protein 3 (Transmembrane protein 7).

AMGO3_MOUSE
NC score	0.042202 (rank : 1360)	θ value	5.27518 (rank : 1542)
Query Neighborhood Hits	1762	Target Neighborhood Hits	276	Shared Neighborhood Hits	80
SwissProt Accessions	Q8C2S7, Q6ZPH1, Q8CEB3	Gene names	Amigo3, Ali3, Kiaa1851
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 3 precursor (AMIGO-3) (Alivin-3).

ASPP2_HUMAN
NC score	0.042157 (rank : 1361)	θ value	0.00228821 (rank : 932)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1156	Shared Neighborhood Hits	221
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

SFR15_HUMAN
NC score	0.042031 (rank : 1362)	θ value	8.99809 (rank : 1743)
Query Neighborhood Hits	1762	Target Neighborhood Hits	368	Shared Neighborhood Hits	134
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

CJ012_HUMAN
NC score	0.041960 (rank : 1363)	θ value	3.0926 (rank : 1451)
Query Neighborhood Hits	1762	Target Neighborhood Hits	467	Shared Neighborhood Hits	126
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

LNK_HUMAN
NC score	0.041948 (rank : 1364)	θ value	0.813845 (rank : 1237)
Query Neighborhood Hits	1762	Target Neighborhood Hits	151	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

TB182_HUMAN
NC score	0.041718 (rank : 1365)	θ value	0.21417 (rank : 1131)
Query Neighborhood Hits	1762	Target Neighborhood Hits	414	Shared Neighborhood Hits	140
SwissProt Accessions	Q9C0C2	Gene names	TNKS1BP1, KIAA1741, TAB182
Domain Architecture	No domain graphic available
Description	182 kDa tankyrase 1-binding protein.

JPH2_HUMAN
NC score	0.041498 (rank : 1366)	θ value	0.0113563 (rank : 993)
Query Neighborhood Hits	1762	Target Neighborhood Hits	639	Shared Neighborhood Hits	225
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

MLL3_HUMAN
NC score	0.041173 (rank : 1367)	θ value	0.21417 (rank : 1127)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1644	Shared Neighborhood Hits	369
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

SFRIP_HUMAN
NC score	0.041135 (rank : 1368)	θ value	1.38821 (rank : 1338)
Query Neighborhood Hits	1762	Target Neighborhood Hits	530	Shared Neighborhood Hits	131
SwissProt Accessions	Q99590, Q8IW59	Gene names	SFRS2IP, CASP11, SIP1
Domain Architecture	No domain graphic available
Description	SFRS2-interacting protein (Splicing factor, arginine/serine-rich 2- interacting protein) (SC35-interacting protein 1) (CTD-associated SR protein 11) (Splicing regulatory protein 129) (SRrp129) (NY-REN-40 antigen).

MISS_MOUSE
NC score	0.040869 (rank : 1369)	θ value	0.47712 (rank : 1181)
Query Neighborhood Hits	1762	Target Neighborhood Hits	444	Shared Neighborhood Hits	160
SwissProt Accessions	Q9D7G9, Q7M749	Gene names	Mapk1ip1, Miss
Domain Architecture	No domain graphic available
Description	MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1).

CSKI2_HUMAN
NC score	0.040435 (rank : 1370)	θ value	0.21417 (rank : 1123)
Query Neighborhood Hits	1762	Target Neighborhood Hits	747	Shared Neighborhood Hits	244
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

FMN2_HUMAN
NC score	0.040412 (rank : 1371)	θ value	1.38821 (rank : 1309)
Query Neighborhood Hits	1762	Target Neighborhood Hits	484	Shared Neighborhood Hits	179
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

IWS1_HUMAN
NC score	0.040334 (rank : 1372)	θ value	0.000270298 (rank : 871)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1241	Shared Neighborhood Hits	224
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

DOT1L_HUMAN
NC score	0.040214 (rank : 1373)	θ value	3.0926 (rank : 1456)
Query Neighborhood Hits	1762	Target Neighborhood Hits	660	Shared Neighborhood Hits	198
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

MAP1B_HUMAN
NC score	0.040189 (rank : 1374)	θ value	0.813845 (rank : 1239)
Query Neighborhood Hits	1762	Target Neighborhood Hits	903	Shared Neighborhood Hits	165
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

PI5PA_MOUSE
NC score	0.040077 (rank : 1375)	θ value	0.47712 (rank : 1184)
Query Neighborhood Hits	1762	Target Neighborhood Hits	331	Shared Neighborhood Hits	156
SwissProt Accessions	P59644	Gene names	Pib5pa
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

SPR1B_HUMAN
NC score	0.040016 (rank : 1376)	θ value	0.0193708 (rank : 1010)
Query Neighborhood Hits	1762	Target Neighborhood Hits	102	Shared Neighborhood Hits	25
SwissProt Accessions	P22528, P22529, P22530, Q5T524	Gene names	SPRR1B
Domain Architecture	No domain graphic available
Description	Cornifin B (Small proline-rich protein IB) (SPR-IB) (14.9 kDa pancornulin).

TARA_MOUSE
NC score	0.039913 (rank : 1377)	θ value	3.0926 (rank : 1485)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1133	Shared Neighborhood Hits	257
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

ZAR1_HUMAN
NC score	0.039868 (rank : 1378)	θ value	0.365318 (rank : 1168)
Query Neighborhood Hits	1762	Target Neighborhood Hits	163	Shared Neighborhood Hits	64
SwissProt Accessions	Q86SH2	Gene names	ZAR1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

BCL9_HUMAN
NC score	0.039676 (rank : 1379)	θ value	0.813845 (rank : 1221)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1008	Shared Neighborhood Hits	283
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

SNPC4_HUMAN
NC score	0.039519 (rank : 1380)	θ value	0.125558 (rank : 1099)
Query Neighborhood Hits	1762	Target Neighborhood Hits	589	Shared Neighborhood Hits	204
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

BT1A1_MOUSE
NC score	0.039440 (rank : 1381)	θ value	0.0431538 (rank : 1039)
Query Neighborhood Hits	1762	Target Neighborhood Hits	252	Shared Neighborhood Hits	100
SwissProt Accessions	Q62556, P97392, Q8K2H7, Q921K7	Gene names	Btn1a1, Btn
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

CABIN_HUMAN
NC score	0.039382 (rank : 1382)	θ value	8.99809 (rank : 1675)
Query Neighborhood Hits	1762	Target Neighborhood Hits	490	Shared Neighborhood Hits	183
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

MUCDL_HUMAN
NC score	0.039084 (rank : 1383)	θ value	0.00390308 (rank : 957)
Query Neighborhood Hits	1762	Target Neighborhood Hits	777	Shared Neighborhood Hits	248
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

TENS4_MOUSE
NC score	0.038896 (rank : 1384)	θ value	2.36792 (rank : 1440)
Query Neighborhood Hits	1762	Target Neighborhood Hits	225	Shared Neighborhood Hits	96
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

MILK1_MOUSE
NC score	0.038762 (rank : 1385)	θ value	0.47712 (rank : 1180)
Query Neighborhood Hits	1762	Target Neighborhood Hits	788	Shared Neighborhood Hits	275
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

K1543_MOUSE
NC score	0.038689 (rank : 1386)	θ value	3.0926 (rank : 1469)
Query Neighborhood Hits	1762	Target Neighborhood Hits	497	Shared Neighborhood Hits	170
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

SF01_MOUSE
NC score	0.038533 (rank : 1387)	θ value	1.06291 (rank : 1287)
Query Neighborhood Hits	1762	Target Neighborhood Hits	240	Shared Neighborhood Hits	119
SwissProt Accessions	Q64213, O08817, P70167, Q61454, Q921Z4	Gene names	Sf1, Zfm1, Zfp162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (mZFM) (Zinc finger gene in MEN1 locus) (Mammalian branch point- binding protein mBBP) (BBP) (CW17).

WASP_MOUSE
NC score	0.038318 (rank : 1388)	θ value	4.03905 (rank : 1535)
Query Neighborhood Hits	1762	Target Neighborhood Hits	223	Shared Neighborhood Hits	129
SwissProt Accessions	P70315	Gene names	Was, Wasp
Domain Architecture
Description	Wiskott-Aldrich syndrome protein homolog (WASp).

IWS1_MOUSE
NC score	0.038234 (rank : 1389)	θ value	0.0252991 (rank : 1016)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1258	Shared Neighborhood Hits	236
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

PSL1_HUMAN
NC score	0.038091 (rank : 1390)	θ value	0.62314 (rank : 1208)
Query Neighborhood Hits	1762	Target Neighborhood Hits	650	Shared Neighborhood Hits	215
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

GP116_HUMAN
NC score	0.037890 (rank : 1391)	θ value	5.27518 (rank : 1564)
Query Neighborhood Hits	1762	Target Neighborhood Hits	167	Shared Neighborhood Hits	67
SwissProt Accessions	Q8IZF2, O94858, Q6RGN2, Q86SP0, Q9Y3Z2	Gene names	GPR116, KIAA0758
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 116 precursor.

ARI1A_HUMAN
NC score	0.037804 (rank : 1392)	θ value	0.125558 (rank : 1084)
Query Neighborhood Hits	1762	Target Neighborhood Hits	787	Shared Neighborhood Hits	246
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

TM108_HUMAN
NC score	0.037747 (rank : 1393)	θ value	4.03905 (rank : 1531)
Query Neighborhood Hits	1762	Target Neighborhood Hits	166	Shared Neighborhood Hits	89
SwissProt Accessions	Q6UXF1, Q9BQH1, Q9BW81, Q9C0H3	Gene names	TMEM108, KIAA1690
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

DREB_HUMAN
NC score	0.037721 (rank : 1394)	θ value	5.27518 (rank : 1557)
Query Neighborhood Hits	1762	Target Neighborhood Hits	450	Shared Neighborhood Hits	91
SwissProt Accessions	Q16643	Gene names	DBN1
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

SHC2_HUMAN
NC score	0.037642 (rank : 1395)	θ value	8.99809 (rank : 1744)
Query Neighborhood Hits	1762	Target Neighborhood Hits	170	Shared Neighborhood Hits	61
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

K1802_MOUSE
NC score	0.037424 (rank : 1396)	θ value	0.00298849 (rank : 941)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1596	Shared Neighborhood Hits	354
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

ANK2_HUMAN
NC score	0.037309 (rank : 1397)	θ value	0.279714 (rank : 1136)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1615	Shared Neighborhood Hits	364
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

SC24C_HUMAN
NC score	0.037291 (rank : 1398)	θ value	0.365318 (rank : 1164)
Query Neighborhood Hits	1762	Target Neighborhood Hits	662	Shared Neighborhood Hits	210
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

PRAX_HUMAN
NC score	0.037257 (rank : 1399)	θ value	8.99809 (rank : 1732)
Query Neighborhood Hits	1762	Target Neighborhood Hits	215	Shared Neighborhood Hits	72
SwissProt Accessions	Q9BXM0, Q9BXL9, Q9HCF2	Gene names	PRX, KIAA1620
Domain Architecture
Description	Periaxin.

CNTRB_MOUSE
NC score	0.037083 (rank : 1400)	θ value	0.00298849 (rank : 939)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1029	Shared Neighborhood Hits	143
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

MAP1B_MOUSE
NC score	0.037060 (rank : 1401)	θ value	1.06291 (rank : 1274)
Query Neighborhood Hits	1762	Target Neighborhood Hits	977	Shared Neighborhood Hits	171
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

NPBL_MOUSE
NC score	0.037055 (rank : 1402)	θ value	0.0961366 (rank : 1078)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1041	Shared Neighborhood Hits	219
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

SFRS8_HUMAN
NC score	0.036955 (rank : 1403)	θ value	1.38821 (rank : 1339)
Query Neighborhood Hits	1762	Target Neighborhood Hits	166	Shared Neighborhood Hits	59
SwissProt Accessions	Q12872	Gene names	SFRS8, SWAP
Domain Architecture
Description	Splicing factor, arginine/serine-rich 8 (Suppressor of white apricot protein homolog).

MLL3_MOUSE
NC score	0.036737 (rank : 1404)	θ value	0.0193708 (rank : 1008)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1399	Shared Neighborhood Hits	314
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

PININ_HUMAN
NC score	0.036436 (rank : 1405)	θ value	3.0926 (rank : 1476)
Query Neighborhood Hits	1762	Target Neighborhood Hits	753	Shared Neighborhood Hits	116
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

PPRB_HUMAN
NC score	0.036394 (rank : 1406)	θ value	5.27518 (rank : 1580)
Query Neighborhood Hits	1762	Target Neighborhood Hits	311	Shared Neighborhood Hits	102
SwissProt Accessions	Q15648, O43810, O75447, Q9HD39	Gene names	PPARBP, ARC205, DRIP205, TRAP220, TRIP2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2) (p53 regulatory protein RB18A) (Vitamin D receptor-interacting protein complex component DRIP205) (Activator- recruited cofactor 205 kDa component) (ARC205).

APXL_HUMAN
NC score	0.036193 (rank : 1407)	θ value	1.06291 (rank : 1257)
Query Neighborhood Hits	1762	Target Neighborhood Hits	553	Shared Neighborhood Hits	144
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

CS007_MOUSE
NC score	0.035934 (rank : 1408)	θ value	0.62314 (rank : 1196)
Query Neighborhood Hits	1762	Target Neighborhood Hits	464	Shared Neighborhood Hits	153
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

TULP4_HUMAN
NC score	0.035923 (rank : 1409)	θ value	0.000121331 (rank : 855)
Query Neighborhood Hits	1762	Target Neighborhood Hits	426	Shared Neighborhood Hits	100
SwissProt Accessions	Q9NRJ4, Q9HD22, Q9P2F0	Gene names	TULP4, KIAA1397, TUSP
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

MAVS_HUMAN
NC score	0.035800 (rank : 1410)	θ value	1.81305 (rank : 1365)
Query Neighborhood Hits	1762	Target Neighborhood Hits	271	Shared Neighborhood Hits	112
SwissProt Accessions	Q7Z434, Q3I0Y2, Q5T7I6, Q86VY7, Q9H1H3, Q9H4Y1, Q9H8D3, Q9ULE9	Gene names	MAVS, IPS1, KIAA1271, VISA
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif) (Putative NF-kappa-B- activating protein 031N).

SMOO_HUMAN
NC score	0.035547 (rank : 1411)	θ value	0.0330416 (rank : 1035)
Query Neighborhood Hits	1762	Target Neighborhood Hits	391	Shared Neighborhood Hits	159
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

DIDO1_HUMAN
NC score	0.035368 (rank : 1412)	θ value	0.813845 (rank : 1223)
Query Neighborhood Hits	1762	Target Neighborhood Hits	960	Shared Neighborhood Hits	257
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

PHLB1_HUMAN
NC score	0.035321 (rank : 1413)	θ value	0.0330416 (rank : 1034)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1038	Shared Neighborhood Hits	209
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PS1C2_MOUSE
NC score	0.034784 (rank : 1414)	θ value	6.88961 (rank : 1644)
Query Neighborhood Hits	1762	Target Neighborhood Hits	59	Shared Neighborhood Hits	32
SwissProt Accessions	Q80ZC9	Gene names	Psors1c2, Spr1
Domain Architecture	No domain graphic available
Description	Psoriasis susceptibility 1 candidate gene 2 protein homolog precursor (SPR1 protein).

CO002_HUMAN
NC score	0.034644 (rank : 1415)	θ value	2.36792 (rank : 1400)
Query Neighborhood Hits	1762	Target Neighborhood Hits	387	Shared Neighborhood Hits	129
SwissProt Accessions	Q9NZP6	Gene names	C15orf2
Domain Architecture	No domain graphic available
Description	Protein C15orf2.

RIMB1_MOUSE
NC score	0.034616 (rank : 1416)	θ value	3.0926 (rank : 1480)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1376	Shared Neighborhood Hits	222
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

TENS4_HUMAN
NC score	0.034577 (rank : 1417)	θ value	0.62314 (rank : 1214)
Query Neighborhood Hits	1762	Target Neighborhood Hits	214	Shared Neighborhood Hits	78
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

MTSS1_HUMAN
NC score	0.034490 (rank : 1418)	θ value	0.62314 (rank : 1206)
Query Neighborhood Hits	1762	Target Neighborhood Hits	504	Shared Neighborhood Hits	137
SwissProt Accessions	O43312, Q8TCA2, Q96RX2	Gene names	MTSS1, KIAA0429, MIM
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein) (Metastasis suppressor YGL-1).

EFS_MOUSE
NC score	0.034471 (rank : 1419)	θ value	0.279714 (rank : 1140)
Query Neighborhood Hits	1762	Target Neighborhood Hits	389	Shared Neighborhood Hits	130
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

BCAR1_HUMAN
NC score	0.034126 (rank : 1420)	θ value	6.88961 (rank : 1601)
Query Neighborhood Hits	1762	Target Neighborhood Hits	554	Shared Neighborhood Hits	188
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

MUC5B_HUMAN
NC score	0.034048 (rank : 1421)	θ value	1.38821 (rank : 1324)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1020	Shared Neighborhood Hits	242
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

BAG3_HUMAN
NC score	0.033724 (rank : 1422)	θ value	8.99809 (rank : 1671)
Query Neighborhood Hits	1762	Target Neighborhood Hits	314	Shared Neighborhood Hits	129
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

BAG3_MOUSE
NC score	0.033367 (rank : 1423)	θ value	8.99809 (rank : 1672)
Query Neighborhood Hits	1762	Target Neighborhood Hits	513	Shared Neighborhood Hits	185
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

RP3A_MOUSE
NC score	0.033236 (rank : 1424)	θ value	0.62314 (rank : 1210)
Query Neighborhood Hits	1762	Target Neighborhood Hits	510	Shared Neighborhood Hits	176
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

OGFR_MOUSE
NC score	0.032796 (rank : 1425)	θ value	0.365318 (rank : 1161)
Query Neighborhood Hits	1762	Target Neighborhood Hits	584	Shared Neighborhood Hits	162
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

MKL1_MOUSE
NC score	0.032708 (rank : 1426)	θ value	0.279714 (rank : 1146)
Query Neighborhood Hits	1762	Target Neighborhood Hits	667	Shared Neighborhood Hits	189
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

LR37B_HUMAN
NC score	0.032548 (rank : 1427)	θ value	5.27518 (rank : 1571)
Query Neighborhood Hits	1762	Target Neighborhood Hits	392	Shared Neighborhood Hits	109
SwissProt Accessions	Q96QE4, Q5YKG6	Gene names	LRRC37B
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37B precursor (C66 SLIT-like testicular protein).

K1802_HUMAN
NC score	0.032542 (rank : 1428)	θ value	0.163984 (rank : 1109)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1378	Shared Neighborhood Hits	324
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

SFR16_HUMAN
NC score	0.032500 (rank : 1429)	θ value	0.163984 (rank : 1116)
Query Neighborhood Hits	1762	Target Neighborhood Hits	178	Shared Neighborhood Hits	48
SwissProt Accessions	Q8N2M8, O96026, Q6UW71, Q96DX2	Gene names	SFRS16, SWAP2
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 16 (Suppressor of white-apricot homolog 2).

XRCC1_HUMAN
NC score	0.032454 (rank : 1430)	θ value	0.0193708 (rank : 1011)
Query Neighborhood Hits	1762	Target Neighborhood Hits	131	Shared Neighborhood Hits	56
SwissProt Accessions	P18887, Q9HCB1	Gene names	XRCC1
Domain Architecture
Description	DNA-repair protein XRCC1 (X-ray repair cross-complementing protein 1).

CG1_HUMAN
NC score	0.032345 (rank : 1431)	θ value	6.88961 (rank : 1607)
Query Neighborhood Hits	1762	Target Neighborhood Hits	222	Shared Neighborhood Hits	86
SwissProt Accessions	Q13495	Gene names	CXorf6, CG1
Domain Architecture	No domain graphic available
Description	CG1 protein (F18).

PTN23_MOUSE
NC score	0.032330 (rank : 1432)	θ value	1.81305 (rank : 1371)
Query Neighborhood Hits	1762	Target Neighborhood Hits	726	Shared Neighborhood Hits	223
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

SYP2L_HUMAN
NC score	0.032261 (rank : 1433)	θ value	4.03905 (rank : 1529)
Query Neighborhood Hits	1762	Target Neighborhood Hits	400	Shared Neighborhood Hits	157
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

CRTC1_HUMAN
NC score	0.032221 (rank : 1434)	θ value	8.99809 (rank : 1684)
Query Neighborhood Hits	1762	Target Neighborhood Hits	319	Shared Neighborhood Hits	140
SwissProt Accessions	Q6UUV9, O75114, Q6Y3A3, Q7LDZ2, Q8IUL3, Q8IZ34, Q8IZL1, Q8N6W3, Q96AI8, Q9H801	Gene names	CRTC1, KIAA0616, MECT1, TORC1, WAMTP1
Domain Architecture	No domain graphic available
Description	CREB-regulated transcription coactivator 1 (Transducer of regulated cAMP response element-binding protein 1) (Transducer of CREB protein 1) (Mucoepidermoid carcinoma translocated protein 1).

RP3A_HUMAN
NC score	0.032025 (rank : 1435)	θ value	0.0961366 (rank : 1081)
Query Neighborhood Hits	1762	Target Neighborhood Hits	305	Shared Neighborhood Hits	102
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SF3B1_MOUSE
NC score	0.032021 (rank : 1436)	θ value	1.38821 (rank : 1337)
Query Neighborhood Hits	1762	Target Neighborhood Hits	352	Shared Neighborhood Hits	122
SwissProt Accessions	Q99NB9, Q9CSK5	Gene names	Sf3b1, Sap155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

CS007_HUMAN
NC score	0.031883 (rank : 1437)	θ value	5.27518 (rank : 1552)
Query Neighborhood Hits	1762	Target Neighborhood Hits	401	Shared Neighborhood Hits	156
SwissProt Accessions	Q9UPT8, Q9Y420	Gene names	C19orf7, KIAA1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7.

AMOT_HUMAN
NC score	0.031831 (rank : 1438)	θ value	1.81305 (rank : 1349)
Query Neighborhood Hits	1762	Target Neighborhood Hits	712	Shared Neighborhood Hits	151
SwissProt Accessions	Q4VCS5, Q504X5, Q9HD27, Q9UPT1	Gene names	AMOT, KIAA1071
Domain Architecture	No domain graphic available
Description	Angiomotin.

BCAR1_MOUSE
NC score	0.031701 (rank : 1439)	θ value	6.88961 (rank : 1602)
Query Neighborhood Hits	1762	Target Neighborhood Hits	438	Shared Neighborhood Hits	157
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CTDP1_HUMAN
NC score	0.031321 (rank : 1440)	θ value	2.36792 (rank : 1401)
Query Neighborhood Hits	1762	Target Neighborhood Hits	416	Shared Neighborhood Hits	146
SwissProt Accessions	Q9Y5B0, Q7Z644, Q96BZ1, Q9Y6F5	Gene names	CTDP1, FCP1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

SF3B1_HUMAN
NC score	0.031184 (rank : 1441)	θ value	1.38821 (rank : 1336)
Query Neighborhood Hits	1762	Target Neighborhood Hits	341	Shared Neighborhood Hits	118
SwissProt Accessions	O75533	Gene names	SF3B1, SAP155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

GPS2_HUMAN
NC score	0.030993 (rank : 1442)	θ value	2.36792 (rank : 1412)
Query Neighborhood Hits	1762	Target Neighborhood Hits	459	Shared Neighborhood Hits	96
SwissProt Accessions	Q13227	Gene names	GPS2
Domain Architecture	No domain graphic available
Description	G protein pathway suppressor 2 (Protein GPS2).

MEGF9_MOUSE
NC score	0.030887 (rank : 1443)	θ value	0.47712 (rank : 1178)
Query Neighborhood Hits	1762	Target Neighborhood Hits	896	Shared Neighborhood Hits	239
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

ES8L2_HUMAN
NC score	0.030857 (rank : 1444)	θ value	1.81305 (rank : 1359)
Query Neighborhood Hits	1762	Target Neighborhood Hits	193	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

FMN1B_MOUSE
NC score	0.030803 (rank : 1445)	θ value	6.88961 (rank : 1619)
Query Neighborhood Hits	1762	Target Neighborhood Hits	447	Shared Neighborhood Hits	171
SwissProt Accessions	Q05859	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoform IV (Limb deformity protein).

TACT_HUMAN
NC score	0.030791 (rank : 1446)	θ value	0.62314 (rank : 1213)
Query Neighborhood Hits	1762	Target Neighborhood Hits	100	Shared Neighborhood Hits	37
SwissProt Accessions	P40200	Gene names	CD96
Domain Architecture	No domain graphic available
Description	T-cell surface protein tactile precursor (T cell-activated increased late expression protein) (CD96 antigen).

JIP2_HUMAN
NC score	0.030662 (rank : 1447)	θ value	0.365318 (rank : 1156)
Query Neighborhood Hits	1762	Target Neighborhood Hits	288	Shared Neighborhood Hits	99
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

SVIL_MOUSE
NC score	0.030432 (rank : 1448)	θ value	0.0330416 (rank : 1036)
Query Neighborhood Hits	1762	Target Neighborhood Hits	439	Shared Neighborhood Hits	103
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

BTBDC_HUMAN
NC score	0.030288 (rank : 1449)	θ value	1.06291 (rank : 1258)
Query Neighborhood Hits	1762	Target Neighborhood Hits	248	Shared Neighborhood Hits	70
SwissProt Accessions	Q8IY92, Q96JP1	Gene names	BTBD12, KIAA1784
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 12.

SEPT9_HUMAN
NC score	0.029969 (rank : 1450)	θ value	0.00869519 (rank : 987)
Query Neighborhood Hits	1762	Target Neighborhood Hits	706	Shared Neighborhood Hits	218
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

FMN1A_MOUSE
NC score	0.029947 (rank : 1451)	θ value	6.88961 (rank : 1618)
Query Neighborhood Hits	1762	Target Neighborhood Hits	423	Shared Neighborhood Hits	166
SwissProt Accessions	Q05860	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoforms I/II/III (Limb deformity protein).

PTN23_HUMAN
NC score	0.029927 (rank : 1452)	θ value	3.0926 (rank : 1478)
Query Neighborhood Hits	1762	Target Neighborhood Hits	646	Shared Neighborhood Hits	190
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

INCE_HUMAN
NC score	0.029717 (rank : 1453)	θ value	4.03905 (rank : 1512)
Query Neighborhood Hits	1762	Target Neighborhood Hits	978	Shared Neighborhood Hits	119
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

ACD_HUMAN
NC score	0.029582 (rank : 1454)	θ value	0.365318 (rank : 1151)
Query Neighborhood Hits	1762	Target Neighborhood Hits	143	Shared Neighborhood Hits	63
SwissProt Accessions	Q96AP0, Q562H5, Q9H8F9	Gene names	ACD, PIP1, PTOP
Domain Architecture	No domain graphic available
Description	Adrenocortical dysplasia protein homolog (POT1 and TIN2-interacting protein).

PS1C2_HUMAN
NC score	0.029445 (rank : 1455)	θ value	8.99809 (rank : 1735)
Query Neighborhood Hits	1762	Target Neighborhood Hits	66	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UIG4	Gene names	PSORS1C2, C6orf17, SPR1
Domain Architecture	No domain graphic available
Description	Psoriasis susceptibility 1 candidate gene 2 protein precursor (SPR1 protein).

RFX1_HUMAN
NC score	0.029337 (rank : 1456)	θ value	1.81305 (rank : 1373)
Query Neighborhood Hits	1762	Target Neighborhood Hits	256	Shared Neighborhood Hits	132
SwissProt Accessions	P22670	Gene names	RFX1
Domain Architecture
Description	MHC class II regulatory factor RFX1 (RFX) (Enhancer factor C) (EF-C).

FYB_MOUSE
NC score	0.029299 (rank : 1457)	θ value	2.36792 (rank : 1408)
Query Neighborhood Hits	1762	Target Neighborhood Hits	194	Shared Neighborhood Hits	65
SwissProt Accessions	O35601, Q9Z2H3	Gene names	Fyb
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

LPP_HUMAN
NC score	0.029288 (rank : 1458)	θ value	0.00665767 (rank : 972)
Query Neighborhood Hits	1762	Target Neighborhood Hits	775	Shared Neighborhood Hits	221
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

CF150_HUMAN
NC score	0.029264 (rank : 1459)	θ value	1.38821 (rank : 1300)
Query Neighborhood Hits	1762	Target Neighborhood Hits	96	Shared Neighborhood Hits	37
SwissProt Accessions	Q8N884, Q32NC9, Q5SWL0, Q5SWL1, Q96E45	Gene names	C6orf150
Domain Architecture	No domain graphic available
Description	Protein C6orf150.

JPH2_MOUSE
NC score	0.029203 (rank : 1460)	θ value	1.06291 (rank : 1271)
Query Neighborhood Hits	1762	Target Neighborhood Hits	279	Shared Neighborhood Hits	114
SwissProt Accessions	Q9ET78, Q9ET79	Gene names	Jph2, Jp2
Domain Architecture	No domain graphic available
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

AL2S4_MOUSE
NC score	0.029200 (rank : 1461)	θ value	1.06291 (rank : 1256)
Query Neighborhood Hits	1762	Target Neighborhood Hits	193	Shared Neighborhood Hits	61
SwissProt Accessions	Q3V0J1, Q3TIS2	Gene names	Als2cr4
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog.

SYN3_HUMAN
NC score	0.029115 (rank : 1462)	θ value	3.0926 (rank : 1484)
Query Neighborhood Hits	1762	Target Neighborhood Hits	203	Shared Neighborhood Hits	96
SwissProt Accessions	O14994	Gene names	SYN3
Domain Architecture
Description	Synapsin-3 (Synapsin III).

SDC3_MOUSE
NC score	0.029112 (rank : 1463)	θ value	1.81305 (rank : 1376)
Query Neighborhood Hits	1762	Target Neighborhood Hits	107	Shared Neighborhood Hits	55
SwissProt Accessions	Q64519, Q3UDD9, Q6ZQA4, Q7TQD4	Gene names	Sdc3, Kiaa0468
Domain Architecture
Description	Syndecan-3 precursor (SYND3).

RASL1_MOUSE
NC score	0.028771 (rank : 1464)	θ value	0.813845 (rank : 1244)
Query Neighborhood Hits	1762	Target Neighborhood Hits	148	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

PHC2_HUMAN
NC score	0.028197 (rank : 1465)	θ value	0.163984 (rank : 1114)
Query Neighborhood Hits	1762	Target Neighborhood Hits	388	Shared Neighborhood Hits	154
SwissProt Accessions	Q8IXK0, Q5T0C1, Q6NUJ6, Q6ZQR1, Q8N306, Q8TAG8, Q96BL4, Q9Y4Y7	Gene names	PHC2, EDR2, PH2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2).

BAT3_MOUSE
NC score	0.028080 (rank : 1466)	θ value	8.99809 (rank : 1674)
Query Neighborhood Hits	1762	Target Neighborhood Hits	518	Shared Neighborhood Hits	177
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

VINEX_MOUSE
NC score	0.028066 (rank : 1467)	θ value	1.06291 (rank : 1292)
Query Neighborhood Hits	1762	Target Neighborhood Hits	286	Shared Neighborhood Hits	76
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

SVIL_HUMAN
NC score	0.028009 (rank : 1468)	θ value	0.00869519 (rank : 989)
Query Neighborhood Hits	1762	Target Neighborhood Hits	232	Shared Neighborhood Hits	60
SwissProt Accessions	O95425, O60611, O60612, Q5VZK5, Q5VZK6, Q9H1R7	Gene names	SVIL
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

PAF49_HUMAN
NC score	0.027971 (rank : 1469)	θ value	2.36792 (rank : 1425)
Query Neighborhood Hits	1762	Target Neighborhood Hits	169	Shared Neighborhood Hits	68
SwissProt Accessions	O15446, Q32N11, Q7Z5U2, Q9UPF6	Gene names	CD3EAP, ASE1, CAST, PAF49
Domain Architecture	No domain graphic available
Description	RNA polymerase I-associated factor PAF49 (Anti-sense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (CAST).

RU1C_MOUSE
NC score	0.027799 (rank : 1470)	θ value	1.06291 (rank : 1285)
Query Neighborhood Hits	1762	Target Neighborhood Hits	83	Shared Neighborhood Hits	39
SwissProt Accessions	Q62241	Gene names	Snrp1c, Snrpc
Domain Architecture
Description	U1 small nuclear ribonucleoprotein C (U1 snRNP protein C) (U1C protein) (U1-C).

TXLNA_HUMAN
NC score	0.027797 (rank : 1471)	θ value	0.279714 (rank : 1150)
Query Neighborhood Hits	1762	Target Neighborhood Hits	982	Shared Neighborhood Hits	145
SwissProt Accessions	P40222, Q66K62, Q86T54, Q86T85, Q86T86, Q86Y86, Q86YW3, Q8N2Y3	Gene names	TXLNA, TXLN
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

PDZD2_HUMAN
NC score	0.027484 (rank : 1472)	θ value	0.163984 (rank : 1113)
Query Neighborhood Hits	1762	Target Neighborhood Hits	772	Shared Neighborhood Hits	201
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

CNTRB_HUMAN
NC score	0.027354 (rank : 1473)	θ value	1.81305 (rank : 1357)
Query Neighborhood Hits	1762	Target Neighborhood Hits	690	Shared Neighborhood Hits	86
SwissProt Accessions	Q8N137, Q331K3, Q69YV7, Q8NCB8, Q8WXV3, Q96CQ7, Q9C060	Gene names	CNTROB, LIP8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

PHLB1_MOUSE
NC score	0.027313 (rank : 1474)	θ value	4.03905 (rank : 1520)
Query Neighborhood Hits	1762	Target Neighborhood Hits	678	Shared Neighborhood Hits	142
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

ZN318_HUMAN
NC score	0.027250 (rank : 1475)	θ value	0.0148317 (rank : 1004)
Query Neighborhood Hits	1762	Target Neighborhood Hits	497	Shared Neighborhood Hits	97
SwissProt Accessions	Q5VUA4, O94796, Q4G0E4, Q8NEM6, Q9UNU8, Q9Y2W9	Gene names	ZNF318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Endocrine regulatory protein).

RU1C_HUMAN
NC score	0.027029 (rank : 1476)	θ value	1.06291 (rank : 1284)
Query Neighborhood Hits	1762	Target Neighborhood Hits	81	Shared Neighborhood Hits	37
SwissProt Accessions	P09234	Gene names	SNRPC
Domain Architecture
Description	U1 small nuclear ribonucleoprotein C (U1 snRNP protein C) (U1C protein) (U1-C).

K2027_HUMAN
NC score	0.026903 (rank : 1477)	θ value	3.0926 (rank : 1470)
Query Neighborhood Hits	1762	Target Neighborhood Hits	194	Shared Neighborhood Hits	69
SwissProt Accessions	Q6ZVF9, Q8IVE4	Gene names	KIAA2027
Domain Architecture	No domain graphic available
Description	Protein KIAA2027.

HCLS1_MOUSE
NC score	0.026889 (rank : 1478)	θ value	1.06291 (rank : 1265)
Query Neighborhood Hits	1762	Target Neighborhood Hits	329	Shared Neighborhood Hits	107
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

GA2L2_MOUSE
NC score	0.026858 (rank : 1479)	θ value	5.27518 (rank : 1563)
Query Neighborhood Hits	1762	Target Neighborhood Hits	395	Shared Neighborhood Hits	156
SwissProt Accessions	Q5SSG4	Gene names	Gas2l2
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2).

WBS14_MOUSE
NC score	0.026848 (rank : 1480)	θ value	1.38821 (rank : 1346)
Query Neighborhood Hits	1762	Target Neighborhood Hits	171	Shared Neighborhood Hits	78
SwissProt Accessions	Q99MZ3, Q99MY9, Q99MZ0, Q99MZ1, Q99MZ2, Q9JLM5	Gene names	Mlxipl, Mio, Wbscr14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein homolog (Mlx interactor) (MLX-interacting protein-like).

CEL_HUMAN
NC score	0.026780 (rank : 1481)	θ value	0.0193708 (rank : 1005)
Query Neighborhood Hits	1762	Target Neighborhood Hits	896	Shared Neighborhood Hits	245
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

SYP2L_MOUSE
NC score	0.026735 (rank : 1482)	θ value	1.38821 (rank : 1343)
Query Neighborhood Hits	1762	Target Neighborhood Hits	289	Shared Neighborhood Hits	114
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

SRBS1_HUMAN
NC score	0.026694 (rank : 1483)	θ value	8.99809 (rank : 1746)
Query Neighborhood Hits	1762	Target Neighborhood Hits	396	Shared Neighborhood Hits	104
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

CT174_HUMAN
NC score	0.026549 (rank : 1484)	θ value	4.03905 (rank : 1499)
Query Neighborhood Hits	1762	Target Neighborhood Hits	181	Shared Neighborhood Hits	82
SwissProt Accessions	Q5JPB2, Q5TDR4, Q8TCP0	Gene names	C20orf174
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf174.

IF39_MOUSE
NC score	0.026513 (rank : 1485)	θ value	0.279714 (rank : 1143)
Query Neighborhood Hits	1762	Target Neighborhood Hits	206	Shared Neighborhood Hits	62
SwissProt Accessions	Q8JZQ9, Q922K2	Gene names	Eif3s9
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 3 subunit 9 (eIF-3 eta) (eIF3 p116).

SFR16_MOUSE
NC score	0.026456 (rank : 1486)	θ value	6.88961 (rank : 1649)
Query Neighborhood Hits	1762	Target Neighborhood Hits	177	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CFC7, Q8CFC8, Q9Z2N3	Gene names	Sfrs16, Clasp, Swap2
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 16 (Suppressor of white-apricot homolog 2) (Clk4-associating SR-related protein).

BAT3_HUMAN
NC score	0.026218 (rank : 1487)	θ value	8.99809 (rank : 1673)
Query Neighborhood Hits	1762	Target Neighborhood Hits	490	Shared Neighborhood Hits	169
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

ARMX2_HUMAN
NC score	0.026071 (rank : 1488)	θ value	0.0736092 (rank : 1063)
Query Neighborhood Hits	1762	Target Neighborhood Hits	134	Shared Neighborhood Hits	59
SwissProt Accessions	Q7L311, O60267, Q5H9D9	Gene names	ARMCX2, ALEX2, KIAA0512
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing X-linked protein 2 (Protein ALEX2) (ARM protein lost in epithelial cancers on chromosome X 2).

TSC1_HUMAN
NC score	0.026011 (rank : 1489)	θ value	3.0926 (rank : 1486)
Query Neighborhood Hits	1762	Target Neighborhood Hits	765	Shared Neighborhood Hits	120
SwissProt Accessions	Q92574	Gene names	TSC1, KIAA0243, TSC
Domain Architecture
Description	Hamartin (Tuberous sclerosis 1 protein).

CI079_HUMAN
NC score	0.025954 (rank : 1490)	θ value	1.38821 (rank : 1301)
Query Neighborhood Hits	1762	Target Neighborhood Hits	288	Shared Neighborhood Hits	103
SwissProt Accessions	Q6ZUB1, Q5SQC9, Q8NA41, Q8ND27	Gene names	C9orf79
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf79.

SYN3_MOUSE
NC score	0.025490 (rank : 1491)	θ value	0.62314 (rank : 1212)
Query Neighborhood Hits	1762	Target Neighborhood Hits	200	Shared Neighborhood Hits	101
SwissProt Accessions	Q8JZP2	Gene names	Syn3
Domain Architecture	No domain graphic available
Description	Synapsin-3 (Synapsin III).

SRBS1_MOUSE
NC score	0.025350 (rank : 1492)	θ value	3.0926 (rank : 1482)
Query Neighborhood Hits	1762	Target Neighborhood Hits	409	Shared Neighborhood Hits	109
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

RASL1_HUMAN
NC score	0.025280 (rank : 1493)	θ value	6.88961 (rank : 1648)
Query Neighborhood Hits	1762	Target Neighborhood Hits	142	Shared Neighborhood Hits	28
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

BAZ2A_MOUSE
NC score	0.025256 (rank : 1494)	θ value	2.36792 (rank : 1393)
Query Neighborhood Hits	1762	Target Neighborhood Hits	744	Shared Neighborhood Hits	208
SwissProt Accessions	Q91YE5	Gene names	Baz2a, Tip5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5).

ZAR1_MOUSE
NC score	0.025204 (rank : 1495)	θ value	1.81305 (rank : 1387)
Query Neighborhood Hits	1762	Target Neighborhood Hits	254	Shared Neighborhood Hits	88
SwissProt Accessions	Q80SU3	Gene names	Zar1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

JIP1_HUMAN
NC score	0.025041 (rank : 1496)	θ value	0.0961366 (rank : 1075)
Query Neighborhood Hits	1762	Target Neighborhood Hits	271	Shared Neighborhood Hits	83
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

RTN1_MOUSE
NC score	0.025012 (rank : 1497)	θ value	2.36792 (rank : 1433)
Query Neighborhood Hits	1762	Target Neighborhood Hits	189	Shared Neighborhood Hits	78
SwissProt Accessions	Q8K0T0, Q8K4S4	Gene names	Rtn1, Nsp
Domain Architecture	No domain graphic available
Description	Reticulon-1 (Neuroendocrine-specific protein).

HCN2_HUMAN
NC score	0.024922 (rank : 1498)	θ value	0.0252991 (rank : 1015)
Query Neighborhood Hits	1762	Target Neighborhood Hits	369	Shared Neighborhood Hits	161
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

ZN385_HUMAN
NC score	0.024860 (rank : 1499)	θ value	0.813845 (rank : 1253)
Query Neighborhood Hits	1762	Target Neighborhood Hits	614	Shared Neighborhood Hits	177
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

ZAN_HUMAN
NC score	0.024678 (rank : 1500)	θ value	5.27518 (rank : 1595)
Query Neighborhood Hits	1762	Target Neighborhood Hits	679	Shared Neighborhood Hits	133
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

JIP3_HUMAN
NC score	0.024605 (rank : 1501)	θ value	2.36792 (rank : 1418)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1039	Shared Neighborhood Hits	202
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

TULP4_MOUSE
NC score	0.024408 (rank : 1502)	θ value	0.0961366 (rank : 1083)
Query Neighborhood Hits	1762	Target Neighborhood Hits	247	Shared Neighborhood Hits	54
SwissProt Accessions	Q9JIL5, Q8CA75, Q922C2	Gene names	Tulp4, Tusp
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

CJ108_HUMAN
NC score	0.024189 (rank : 1503)	θ value	0.62314 (rank : 1195)
Query Neighborhood Hits	1762	Target Neighborhood Hits	165	Shared Neighborhood Hits	57
SwissProt Accessions	Q8N8Z3	Gene names	C10orf108
Domain Architecture	No domain graphic available
Description	Putative uncharacterized protein C10orf108.

MEGF9_HUMAN
NC score	0.024130 (rank : 1504)	θ value	6.88961 (rank : 1628)
Query Neighborhood Hits	1762	Target Neighborhood Hits	557	Shared Neighborhood Hits	154
SwissProt Accessions	Q9H1U4, O75098	Gene names	MEGF9, EGFL5, KIAA0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

AIM1_HUMAN
NC score	0.024082 (rank : 1505)	θ value	0.163984 (rank : 1105)
Query Neighborhood Hits	1762	Target Neighborhood Hits	247	Shared Neighborhood Hits	86
SwissProt Accessions	Q9Y4K1, O00296, Q5VWJ2	Gene names	AIM1
Domain Architecture
Description	Absent in melanoma 1 protein.

SREC2_HUMAN
NC score	0.023935 (rank : 1506)	θ value	0.0736092 (rank : 1068)
Query Neighborhood Hits	1762	Target Neighborhood Hits	645	Shared Neighborhood Hits	161
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

GA2L1_MOUSE
NC score	0.023765 (rank : 1507)	θ value	0.813845 (rank : 1230)
Query Neighborhood Hits	1762	Target Neighborhood Hits	114	Shared Neighborhood Hits	56
SwissProt Accessions	Q8JZP9, Q5SVG0, Q8K573	Gene names	Gas2l1
Domain Architecture	No domain graphic available
Description	GAS2-like protein 1 (Growth arrest-specific 2-like 1).

FA61A_MOUSE
NC score	0.023751 (rank : 1508)	θ value	0.00869519 (rank : 980)
Query Neighborhood Hits	1762	Target Neighborhood Hits	81	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K2F8, Q9CTG8	Gene names	Fam61a
Domain Architecture	No domain graphic available
Description	Protein FAM61A.

JIP2_MOUSE
NC score	0.023732 (rank : 1509)	θ value	1.81305 (rank : 1364)
Query Neighborhood Hits	1762	Target Neighborhood Hits	144	Shared Neighborhood Hits	38
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

CD248_HUMAN
NC score	0.023669 (rank : 1510)	θ value	0.0431538 (rank : 1040)
Query Neighborhood Hits	1762	Target Neighborhood Hits	679	Shared Neighborhood Hits	167
SwissProt Accessions	Q9HCU0, Q3SX55, Q96KB6	Gene names	CD248, CD164L1, TEM1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

MYO15_HUMAN
NC score	0.023437 (rank : 1511)	θ value	0.47712 (rank : 1182)
Query Neighborhood Hits	1762	Target Neighborhood Hits	671	Shared Neighborhood Hits	231
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

SPT5H_MOUSE
NC score	0.023368 (rank : 1512)	θ value	6.88961 (rank : 1654)
Query Neighborhood Hits	1762	Target Neighborhood Hits	437	Shared Neighborhood Hits	146
SwissProt Accessions	O55201, Q3UJ77, Q3UJH1, Q3UKD7, Q3UM54, Q6PB73, Q6PDP0, Q6PFR4	Gene names	Supt5h
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit).

SPT5H_HUMAN
NC score	0.023338 (rank : 1513)	θ value	6.88961 (rank : 1653)
Query Neighborhood Hits	1762	Target Neighborhood Hits	436	Shared Neighborhood Hits	146
SwissProt Accessions	O00267, O43279, Q59G52, Q99639	Gene names	SUPT5H, SPT5, SPT5H
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (DSIF p160) (Tat- cotransactivator 1 protein) (Tat-CT1 protein).

RUSC2_MOUSE
NC score	0.023299 (rank : 1514)	θ value	0.21417 (rank : 1130)
Query Neighborhood Hits	1762	Target Neighborhood Hits	305	Shared Neighborhood Hits	111
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

CSF1_HUMAN
NC score	0.023205 (rank : 1515)	θ value	5.27518 (rank : 1553)
Query Neighborhood Hits	1762	Target Neighborhood Hits	258	Shared Neighborhood Hits	115
SwissProt Accessions	P09603, Q13130, Q14086, Q14806, Q9UQR8	Gene names	CSF1
Domain Architecture
Description	Macrophage colony-stimulating factor 1 precursor (CSF-1) (MCSF) (M- CSF) (Lanimostim).

JADE2_MOUSE
NC score	0.023140 (rank : 1516)	θ value	0.0113563 (rank : 992)
Query Neighborhood Hits	1762	Target Neighborhood Hits	560	Shared Neighborhood Hits	180
SwissProt Accessions	Q6ZQF7, Q3UHD5, Q6IE83	Gene names	Phf15, Jade2, Kiaa0239
Domain Architecture	No domain graphic available
Description	Protein Jade-2 (PHD finger protein 15).

PDCD7_MOUSE
NC score	0.023010 (rank : 1517)	θ value	6.88961 (rank : 1640)
Query Neighborhood Hits	1762	Target Neighborhood Hits	214	Shared Neighborhood Hits	75
SwissProt Accessions	Q9WTY1, Q8R5D9	Gene names	Pdcd7
Domain Architecture	No domain graphic available
Description	Programmed cell death protein 7 (ES18).

ALMS1_HUMAN
NC score	0.022932 (rank : 1518)	θ value	1.81305 (rank : 1348)
Query Neighborhood Hits	1762	Target Neighborhood Hits	356	Shared Neighborhood Hits	104
SwissProt Accessions	Q8TCU4, Q53S05, Q580Q8, Q86VP9, Q9Y4G4	Gene names	ALMS1, KIAA0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1.

MKL1_HUMAN
NC score	0.022755 (rank : 1519)	θ value	0.813845 (rank : 1240)
Query Neighborhood Hits	1762	Target Neighborhood Hits	232	Shared Neighborhood Hits	82
SwissProt Accessions	Q969V6, Q8TCL1, Q96SC5, Q96SC6, Q9P2B0	Gene names	MKL1, KIAA1438, MAL
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein).

BAZ2A_HUMAN
NC score	0.022375 (rank : 1520)	θ value	1.81305 (rank : 1353)
Query Neighborhood Hits	1762	Target Neighborhood Hits	780	Shared Neighborhood Hits	183
SwissProt Accessions	Q9UIF9, O00536, O15030, Q96H26	Gene names	BAZ2A, KIAA0314, TIP5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3).

EVL_HUMAN
NC score	0.022106 (rank : 1521)	θ value	8.99809 (rank : 1696)
Query Neighborhood Hits	1762	Target Neighborhood Hits	260	Shared Neighborhood Hits	112
SwissProt Accessions	Q9UI08, O95884, Q7Z522, Q8TBV1, Q9UF25, Q9UIC2	Gene names	EVL, RNB6
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

PDCD7_HUMAN
NC score	0.022050 (rank : 1522)	θ value	8.99809 (rank : 1726)
Query Neighborhood Hits	1762	Target Neighborhood Hits	255	Shared Neighborhood Hits	80
SwissProt Accessions	Q8N8D1, Q96AK8, Q9Y6D7	Gene names	PDCD7
Domain Architecture	No domain graphic available
Description	Programmed cell death protein 7 (ES18) (HES18).

MPP2_MOUSE
NC score	0.021959 (rank : 1523)	θ value	6.88961 (rank : 1633)
Query Neighborhood Hits	1762	Target Neighborhood Hits	189	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

ATX7_HUMAN
NC score	0.021867 (rank : 1524)	θ value	1.81305 (rank : 1351)
Query Neighborhood Hits	1762	Target Neighborhood Hits	351	Shared Neighborhood Hits	114
SwissProt Accessions	O15265, O75328, O75329, Q9Y6P8	Gene names	ATXN7, SCA7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein).

TCP10_HUMAN
NC score	0.021858 (rank : 1525)	θ value	1.81305 (rank : 1381)
Query Neighborhood Hits	1762	Target Neighborhood Hits	134	Shared Neighborhood Hits	49
SwissProt Accessions	Q12799	Gene names	TCP10, TCP10A
Domain Architecture
Description	T-complex protein 10A homolog.

ATX7_MOUSE
NC score	0.021825 (rank : 1526)	θ value	2.36792 (rank : 1392)
Query Neighborhood Hits	1762	Target Neighborhood Hits	328	Shared Neighborhood Hits	122
SwissProt Accessions	Q8R4I1, Q8BL17	Gene names	Atxn7, Sca7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein homolog).

DIAP1_HUMAN
NC score	0.021770 (rank : 1527)	θ value	4.03905 (rank : 1501)
Query Neighborhood Hits	1762	Target Neighborhood Hits	784	Shared Neighborhood Hits	177
SwissProt Accessions	O60610, Q9UC76	Gene names	DIAPH1, DIAP1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).

VASP_HUMAN
NC score	0.021689 (rank : 1528)	θ value	3.0926 (rank : 1487)
Query Neighborhood Hits	1762	Target Neighborhood Hits	201	Shared Neighborhood Hits	93
SwissProt Accessions	P50552, Q6PIZ1, Q93035	Gene names	VASP
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

WASF3_MOUSE
NC score	0.021664 (rank : 1529)	θ value	6.88961 (rank : 1659)
Query Neighborhood Hits	1762	Target Neighborhood Hits	188	Shared Neighborhood Hits	99
SwissProt Accessions	Q8VHI6	Gene names	Wasf3, Wave3
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 3 (WASP-family protein member 3) (Protein WAVE-3).

CN092_MOUSE
NC score	0.021318 (rank : 1530)	θ value	0.125558 (rank : 1088)
Query Neighborhood Hits	1762	Target Neighborhood Hits	206	Shared Neighborhood Hits	64
SwissProt Accessions	Q8BU11, Q80UI2, Q99PN9, Q9CS16	Gene names
Domain Architecture
Description	Epidermal Langerhans cell protein LCP1.

XRCC1_MOUSE
NC score	0.021151 (rank : 1531)	θ value	8.99809 (rank : 1759)
Query Neighborhood Hits	1762	Target Neighborhood Hits	242	Shared Neighborhood Hits	73
SwissProt Accessions	Q60596, Q3THC5, Q5U435, Q7TNQ5	Gene names	Xrcc1, Xrcc-1
Domain Architecture
Description	DNA-repair protein XRCC1 (X-ray repair cross-complementing protein 1).

MUC_MOUSE
NC score	0.021090 (rank : 1532)	θ value	0.813845 (rank : 1242)
Query Neighborhood Hits	1762	Target Neighborhood Hits	242	Shared Neighborhood Hits	42
SwissProt Accessions	P01872	Gene names
Domain Architecture	No domain graphic available
Description	Ig mu chain C region secreted form.

SC24A_MOUSE
NC score	0.021011 (rank : 1533)	θ value	5.27518 (rank : 1586)
Query Neighborhood Hits	1762	Target Neighborhood Hits	394	Shared Neighborhood Hits	150
SwissProt Accessions	Q3U2P1, Q3TQ05, Q3TRG7, Q8BIS0	Gene names	Sec24a
Domain Architecture	No domain graphic available
Description	Protein transport protein Sec24A (SEC24-related protein A).

NPAS4_MOUSE
NC score	0.020960 (rank : 1534)	θ value	2.36792 (rank : 1424)
Query Neighborhood Hits	1762	Target Neighborhood Hits	245	Shared Neighborhood Hits	96
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

PERQ1_MOUSE
NC score	0.020945 (rank : 1535)	θ value	2.36792 (rank : 1427)
Query Neighborhood Hits	1762	Target Neighborhood Hits	215	Shared Neighborhood Hits	47
SwissProt Accessions	Q99MR1	Gene names	Perq1
Domain Architecture
Description	PERQ amino acid rich with GYF domain protein 1.

MN1_HUMAN
NC score	0.020868 (rank : 1536)	θ value	8.99809 (rank : 1716)
Query Neighborhood Hits	1762	Target Neighborhood Hits	196	Shared Neighborhood Hits	80
SwissProt Accessions	Q10571	Gene names	MN1
Domain Architecture	No domain graphic available
Description	Probable tumor suppressor protein MN1.

LSM11_HUMAN
NC score	0.020727 (rank : 1537)	θ value	0.279714 (rank : 1145)
Query Neighborhood Hits	1762	Target Neighborhood Hits	16	Shared Neighborhood Hits	5
SwissProt Accessions	P83369, Q7Z7P0, Q8N975	Gene names	LSM11
Domain Architecture	No domain graphic available
Description	U7 snRNA-associated Sm-like protein LSm11.

EGLN1_MOUSE
NC score	0.020721 (rank : 1538)	θ value	0.000461057 (rank : 880)
Query Neighborhood Hits	1762	Target Neighborhood Hits	88	Shared Neighborhood Hits	32
SwissProt Accessions	Q91YE3, Q8VHJ2, Q922P3	Gene names	Egln1
Domain Architecture
Description	Egl nine homolog 1 (EC 1.14.11.-) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-prolyl hydroxylase 2) (HIF-PH2) (HPH-2) (SM-20).

MUCM_MOUSE
NC score	0.020699 (rank : 1539)	θ value	0.813845 (rank : 1241)
Query Neighborhood Hits	1762	Target Neighborhood Hits	242	Shared Neighborhood Hits	41
SwissProt Accessions	P01873	Gene names
Domain Architecture	No domain graphic available
Description	Ig mu chain C region membrane-bound form.

3BP2_MOUSE
NC score	0.020643 (rank : 1540)	θ value	8.99809 (rank : 1665)
Query Neighborhood Hits	1762	Target Neighborhood Hits	142	Shared Neighborhood Hits	51
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

DSPP_MOUSE
NC score	0.020546 (rank : 1541)	θ value	3.0926 (rank : 1457)
Query Neighborhood Hits	1762	Target Neighborhood Hits	491	Shared Neighborhood Hits	80
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

JIP1_MOUSE
NC score	0.020433 (rank : 1542)	θ value	2.36792 (rank : 1417)
Query Neighborhood Hits	1762	Target Neighborhood Hits	259	Shared Neighborhood Hits	88
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

IF4G1_MOUSE
NC score	0.020425 (rank : 1543)	θ value	5.27518 (rank : 1567)
Query Neighborhood Hits	1762	Target Neighborhood Hits	534	Shared Neighborhood Hits	165
SwissProt Accessions	Q6NZJ6, Q6NZN8, Q8BW99	Gene names	Eif4g1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1).

GP179_HUMAN
NC score	0.020372 (rank : 1544)	θ value	0.279714 (rank : 1142)
Query Neighborhood Hits	1762	Target Neighborhood Hits	372	Shared Neighborhood Hits	103
SwissProt Accessions	Q6PRD1	Gene names	GPR179, GPR158L1
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 179 precursor (Probable G-protein coupled receptor 158-like 1).

CTDP1_MOUSE
NC score	0.020319 (rank : 1545)	θ value	0.125558 (rank : 1089)
Query Neighborhood Hits	1762	Target Neighborhood Hits	146	Shared Neighborhood Hits	50
SwissProt Accessions	Q7TSG2, Q7TSS7, Q9D4S8	Gene names	Ctdp1, Fcp1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

DMRTD_HUMAN
NC score	0.020277 (rank : 1546)	θ value	0.0563607 (rank : 1057)
Query Neighborhood Hits	1762	Target Neighborhood Hits	216	Shared Neighborhood Hits	85
SwissProt Accessions	Q8IXT2, Q8N6Q2, Q96M39, Q96SD4	Gene names	DMRTC2
Domain Architecture	No domain graphic available
Description	Doublesex- and mab-3-related transcription factor C2.

SSBP4_HUMAN
NC score	0.020249 (rank : 1547)	θ value	3.0926 (rank : 1483)
Query Neighborhood Hits	1762	Target Neighborhood Hits	753	Shared Neighborhood Hits	219
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

IL3RB_HUMAN
NC score	0.020233 (rank : 1548)	θ value	0.62314 (rank : 1204)
Query Neighborhood Hits	1762	Target Neighborhood Hits	163	Shared Neighborhood Hits	67
SwissProt Accessions	P32927	Gene names	CSF2RB, IL3RB, IL5RB
Domain Architecture
Description	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen) (CDw131).

AGRIN_HUMAN
NC score	0.020226 (rank : 1549)	θ value	0.365318 (rank : 1152)
Query Neighborhood Hits	1762	Target Neighborhood Hits	582	Shared Neighborhood Hits	90
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

ZN598_HUMAN
NC score	0.020162 (rank : 1550)	θ value	4.03905 (rank : 1539)
Query Neighborhood Hits	1762	Target Neighborhood Hits	339	Shared Neighborhood Hits	91
SwissProt Accessions	Q86UK7, Q8IW49, Q8N3D9, Q96FG3, Q9H7J3	Gene names	ZNF598
Domain Architecture	No domain graphic available
Description	Zinc finger protein 598.

GNAS1_MOUSE
NC score	0.020112 (rank : 1551)	θ value	0.0330416 (rank : 1028)
Query Neighborhood Hits	1762	Target Neighborhood Hits	651	Shared Neighborhood Hits	198
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

HSF1_MOUSE
NC score	0.019945 (rank : 1552)	θ value	0.0330416 (rank : 1029)
Query Neighborhood Hits	1762	Target Neighborhood Hits	267	Shared Neighborhood Hits	88
SwissProt Accessions	P38532, O70462	Gene names	Hsf1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

MYO15_MOUSE
NC score	0.019788 (rank : 1553)	θ value	0.365318 (rank : 1159)
Query Neighborhood Hits	1762	Target Neighborhood Hits	467	Shared Neighborhood Hits	152
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

PER3_HUMAN
NC score	0.019722 (rank : 1554)	θ value	2.36792 (rank : 1426)
Query Neighborhood Hits	1762	Target Neighborhood Hits	479	Shared Neighborhood Hits	161
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

BAG4_HUMAN
NC score	0.019586 (rank : 1555)	θ value	1.38821 (rank : 1296)
Query Neighborhood Hits	1762	Target Neighborhood Hits	96	Shared Neighborhood Hits	34
SwissProt Accessions	O95429, O95818	Gene names	BAG4, SODD
Domain Architecture
Description	BAG family molecular chaperone regulator 4 (BCL2-associated athanogene 4) (BAG-4) (Silencer of death domains).

PHLPP_MOUSE
NC score	0.019297 (rank : 1556)	θ value	8.99809 (rank : 1730)
Query Neighborhood Hits	1762	Target Neighborhood Hits	394	Shared Neighborhood Hits	91
SwissProt Accessions	Q8CHE4, Q6PCN0, Q8QZU8, Q8R5E5, Q99KL6	Gene names	Phlpp, Kiaa0606, Plekhe1, Scop
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein).

TXLNB_MOUSE
NC score	0.019247 (rank : 1557)	θ value	8.99809 (rank : 1756)
Query Neighborhood Hits	1762	Target Neighborhood Hits	640	Shared Neighborhood Hits	95
SwissProt Accessions	Q8VBT1, Q3UVB8, Q8BUK2	Gene names	Txlnb, Mdp77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77).

MY18B_HUMAN
NC score	0.019237 (rank : 1558)	θ value	1.06291 (rank : 1276)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1299	Shared Neighborhood Hits	194
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

ARMX2_MOUSE
NC score	0.019104 (rank : 1559)	θ value	4.03905 (rank : 1493)
Query Neighborhood Hits	1762	Target Neighborhood Hits	349	Shared Neighborhood Hits	114
SwissProt Accessions	Q6A058, Q9CXI9	Gene names	Armcx2, Kiaa0512
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing X-linked protein 2.

MYCB2_MOUSE
NC score	0.019006 (rank : 1560)	θ value	2.36792 (rank : 1422)
Query Neighborhood Hits	1762	Target Neighborhood Hits	307	Shared Neighborhood Hits	69
SwissProt Accessions	Q7TPH6, Q6PCM8	Gene names	Mycbp2, Pam, Phr1
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

SOX13_MOUSE
NC score	0.018934 (rank : 1561)	θ value	0.0193708 (rank : 1009)
Query Neighborhood Hits	1762	Target Neighborhood Hits	495	Shared Neighborhood Hits	140
SwissProt Accessions	Q04891, Q922L3	Gene names	Sox13, Sox-13
Domain Architecture
Description	SOX-13 protein.

NTBP1_MOUSE
NC score	0.018923 (rank : 1562)	θ value	3.0926 (rank : 1474)
Query Neighborhood Hits	1762	Target Neighborhood Hits	528	Shared Neighborhood Hits	91
SwissProt Accessions	Q8BRM2, Q8CAA8	Gene names	Scyl1bp1, Ntklbp1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like-binding protein 1 (NTKL-binding protein 1) (NTKL-BP1) (mNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-binding protein 1) (SCYL1-BP1).

MKL2_HUMAN
NC score	0.018875 (rank : 1563)	θ value	6.88961 (rank : 1631)
Query Neighborhood Hits	1762	Target Neighborhood Hits	274	Shared Neighborhood Hits	86
SwissProt Accessions	Q9ULH7, Q68CT1, Q6UB16, Q86WW2, Q8N226	Gene names	MKL2, KIAA1243, MRTFB
Domain Architecture
Description	MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B) (Megakaryoblastic leukemia 2).

SNIP_MOUSE
NC score	0.018681 (rank : 1564)	θ value	4.03905 (rank : 1528)
Query Neighborhood Hits	1762	Target Neighborhood Hits	319	Shared Neighborhood Hits	83
SwissProt Accessions	Q9QWI6, O70298	Gene names	P140, Kiaa1684
Domain Architecture	No domain graphic available
Description	p130Cas-associated protein (p140Cap) (SNAP-25-interacting protein) (SNIP).

MUCDL_MOUSE
NC score	0.018543 (rank : 1565)	θ value	8.99809 (rank : 1718)
Query Neighborhood Hits	1762	Target Neighborhood Hits	461	Shared Neighborhood Hits	137
SwissProt Accessions	Q8VHF2, Q8CEJ3, Q9D8I9	Gene names	Mucdhl
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

CENPT_MOUSE
NC score	0.018306 (rank : 1566)	θ value	1.38821 (rank : 1299)
Query Neighborhood Hits	1762	Target Neighborhood Hits	115	Shared Neighborhood Hits	51
SwissProt Accessions	Q3TJM4, Q3TPY6, Q3UPD2, Q8BTH0, Q8BTP2, Q8R5E9	Gene names	Cenpt
Domain Architecture	No domain graphic available
Description	Centromere protein T (CENP-T).

EP400_MOUSE
NC score	0.018277 (rank : 1567)	θ value	8.99809 (rank : 1692)
Query Neighborhood Hits	1762	Target Neighborhood Hits	592	Shared Neighborhood Hits	207
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

GA2L1_HUMAN
NC score	0.018094 (rank : 1568)	θ value	1.81305 (rank : 1361)
Query Neighborhood Hits	1762	Target Neighborhood Hits	177	Shared Neighborhood Hits	61
SwissProt Accessions	Q99501, Q53EN7, Q92640, Q9BUY9	Gene names	GAS2L1, GAR22
Domain Architecture
Description	GAS2-like protein 1 (Growth arrest-specific 2-like 1) (GAS2-related protein on chromosome 22) (GAR22 protein).

PCX3_MOUSE
NC score	0.018063 (rank : 1569)	θ value	6.88961 (rank : 1639)
Query Neighborhood Hits	1762	Target Neighborhood Hits	134	Shared Neighborhood Hits	61
SwissProt Accessions	Q8VI59	Gene names	Pcnxl3
Domain Architecture
Description	Pecanex-like protein 3.

CGRE1_HUMAN
NC score	0.018059 (rank : 1570)	θ value	2.36792 (rank : 1398)
Query Neighborhood Hits	1762	Target Neighborhood Hits	354	Shared Neighborhood Hits	98
SwissProt Accessions	Q99674	Gene names	CGREF1, CGR11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

PKHA4_HUMAN
NC score	0.017990 (rank : 1571)	θ value	1.81305 (rank : 1369)
Query Neighborhood Hits	1762	Target Neighborhood Hits	283	Shared Neighborhood Hits	104
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

CSPG5_MOUSE
NC score	0.017974 (rank : 1572)	θ value	1.06291 (rank : 1260)
Query Neighborhood Hits	1762	Target Neighborhood Hits	211	Shared Neighborhood Hits	70
SwissProt Accessions	Q71M36, Q71M37, Q7TNT8, Q8BPJ5, Q9QY32	Gene names	Cspg5, Caleb, Ngc
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 5 precursor (Neuroglycan C) (Acidic leucine-rich EGF-like domain-containing brain protein).

GRASP_HUMAN
NC score	0.017941 (rank : 1573)	θ value	2.36792 (rank : 1413)
Query Neighborhood Hits	1762	Target Neighborhood Hits	147	Shared Neighborhood Hits	30
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

AHTF1_MOUSE
NC score	0.017923 (rank : 1574)	θ value	1.38821 (rank : 1295)
Query Neighborhood Hits	1762	Target Neighborhood Hits	176	Shared Neighborhood Hits	58
SwissProt Accessions	Q8CJF7, Q8BVJ5, Q8VD55	Gene names	Ahctf1, Elys
Domain Architecture	No domain graphic available
Description	AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac).

PLCB3_HUMAN
NC score	0.017788 (rank : 1575)	θ value	3.0926 (rank : 1477)
Query Neighborhood Hits	1762	Target Neighborhood Hits	445	Shared Neighborhood Hits	60
SwissProt Accessions	Q01970	Gene names	PLCB3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

GAK6_HUMAN
NC score	0.017739 (rank : 1576)	θ value	0.62314 (rank : 1201)
Query Neighborhood Hits	1762	Target Neighborhood Hits	392	Shared Neighborhood Hits	125
SwissProt Accessions	P62685	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_8p23.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K115 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

MAP2_HUMAN
NC score	0.017730 (rank : 1577)	θ value	6.88961 (rank : 1626)
Query Neighborhood Hits	1762	Target Neighborhood Hits	348	Shared Neighborhood Hits	96
SwissProt Accessions	P11137, Q99975, Q99976	Gene names	MAP2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2) (MAP-2).

MORC2_HUMAN
NC score	0.017728 (rank : 1578)	θ value	1.81305 (rank : 1366)
Query Neighborhood Hits	1762	Target Neighborhood Hits	207	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Y6X9, Q9UF28, Q9Y6V2	Gene names	MORC2, KIAA0852, ZCWCC1
Domain Architecture
Description	MORC family CW-type zinc finger protein 2 (Zinc finger CW-type coiled- coil domain protein 1).

ESPL1_MOUSE
NC score	0.017680 (rank : 1579)	θ value	0.125558 (rank : 1091)
Query Neighborhood Hits	1762	Target Neighborhood Hits	67	Shared Neighborhood Hits	11
SwissProt Accessions	P60330	Gene names	Espl1, Esp1, Kiaa0165
Domain Architecture
Description	Separin (EC 3.4.22.49) (Separase) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein).

DYN1_HUMAN
NC score	0.017657 (rank : 1580)	θ value	0.813845 (rank : 1224)
Query Neighborhood Hits	1762	Target Neighborhood Hits	216	Shared Neighborhood Hits	107
SwissProt Accessions	Q05193	Gene names	DNM1, DNM
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

MKL2_MOUSE
NC score	0.017649 (rank : 1581)	θ value	1.06291 (rank : 1275)
Query Neighborhood Hits	1762	Target Neighborhood Hits	269	Shared Neighborhood Hits	66
SwissProt Accessions	P59759	Gene names	Mkl2, Mrtfb
Domain Architecture
Description	MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B).

ELOA2_HUMAN
NC score	0.017572 (rank : 1582)	θ value	0.47712 (rank : 1172)
Query Neighborhood Hits	1762	Target Neighborhood Hits	165	Shared Neighborhood Hits	49
SwissProt Accessions	Q8IYF1, Q9P2V9	Gene names	TCEB3B, TCEB3L
Domain Architecture
Description	RNA polymerase II transcription factor SIII subunit A2 (Elongin-A2) (EloA2) (Transcription elongation factor B polypeptide 3B).

RAI1_MOUSE
NC score	0.017476 (rank : 1583)	θ value	4.03905 (rank : 1524)
Query Neighborhood Hits	1762	Target Neighborhood Hits	344	Shared Neighborhood Hits	117
SwissProt Accessions	Q61818, Q6ZPH7, Q8CEV1	Gene names	Rai1, Kiaa1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

RAI1_HUMAN
NC score	0.017435 (rank : 1584)	θ value	6.88961 (rank : 1646)
Query Neighborhood Hits	1762	Target Neighborhood Hits	360	Shared Neighborhood Hits	120
SwissProt Accessions	Q7Z5J4, Q8N3B4, Q8ND08, Q8WU64, Q96JK5, Q9H1C1, Q9H1C2, Q9UF69	Gene names	RAI1, KIAA1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

NPAS4_HUMAN
NC score	0.017387 (rank : 1585)	θ value	1.38821 (rank : 1326)
Query Neighborhood Hits	1762	Target Neighborhood Hits	214	Shared Neighborhood Hits	72
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

GAK4_HUMAN
NC score	0.017222 (rank : 1586)	θ value	1.06291 (rank : 1264)
Query Neighborhood Hits	1762	Target Neighborhood Hits	415	Shared Neighborhood Hits	128
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK5_HUMAN
NC score	0.017180 (rank : 1587)	θ value	0.62314 (rank : 1200)
Query Neighborhood Hits	1762	Target Neighborhood Hits	429	Shared Neighborhood Hits	128
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

IQEC2_MOUSE
NC score	0.017147 (rank : 1588)	θ value	8.99809 (rank : 1708)
Query Neighborhood Hits	1762	Target Neighborhood Hits	417	Shared Neighborhood Hits	156
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

GAK11_HUMAN
NC score	0.017116 (rank : 1589)	θ value	1.06291 (rank : 1262)
Query Neighborhood Hits	1762	Target Neighborhood Hits	409	Shared Neighborhood Hits	127
SwissProt Accessions	P63145, Q9UKI1	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_22q11.21 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K101 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

AB1IP_MOUSE
NC score	0.017048 (rank : 1590)	θ value	8.99809 (rank : 1666)
Query Neighborhood Hits	1762	Target Neighborhood Hits	181	Shared Neighborhood Hits	83
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

PHXR5_MOUSE
NC score	0.016909 (rank : 1591)	θ value	0.62314 (rank : 1207)
Query Neighborhood Hits	1762	Target Neighborhood Hits	102	Shared Neighborhood Hits	19
SwissProt Accessions	P08399	Gene names	Phxr5, Per
Domain Architecture	No domain graphic available
Description	Per-hexamer repeat protein 5.

S23IP_MOUSE
NC score	0.016858 (rank : 1592)	θ value	4.03905 (rank : 1526)
Query Neighborhood Hits	1762	Target Neighborhood Hits	363	Shared Neighborhood Hits	115
SwissProt Accessions	Q6NZC7, Q8BXY6	Gene names	Sec23ip
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein.

CUTL1_MOUSE
NC score	0.016798 (rank : 1593)	θ value	2.36792 (rank : 1402)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1620	Shared Neighborhood Hits	217
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

RTN1_HUMAN
NC score	0.016618 (rank : 1594)	θ value	1.81305 (rank : 1375)
Query Neighborhood Hits	1762	Target Neighborhood Hits	173	Shared Neighborhood Hits	63
SwissProt Accessions	Q16799, Q16800, Q16801	Gene names	RTN1, NSP
Domain Architecture
Description	Reticulon-1 (Neuroendocrine-specific protein).

GAK2_HUMAN
NC score	0.016564 (rank : 1595)	θ value	1.06291 (rank : 1263)
Query Neighborhood Hits	1762	Target Neighborhood Hits	406	Shared Neighborhood Hits	124
SwissProt Accessions	Q7LDI9, Q9UKH5, Q9Y6I1, Q9YNA6, Q9YNB0	Gene names	ERVK6
Domain Architecture	No domain graphic available
Description	HERV-K_7p22.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K(C7) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

WAPL_HUMAN
NC score	0.016485 (rank : 1596)	θ value	0.47712 (rank : 1191)
Query Neighborhood Hits	1762	Target Neighborhood Hits	122	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z5K2, Q5VSK5, Q8IX10, Q92549	Gene names	WAPAL, FOE, KIAA0261, WAPL
Domain Architecture	No domain graphic available
Description	Wings apart-like protein homolog (Friend of EBNA2 protein).

HRX_HUMAN
NC score	0.016436 (rank : 1597)	θ value	5.27518 (rank : 1565)
Query Neighborhood Hits	1762	Target Neighborhood Hits	825	Shared Neighborhood Hits	202
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

K0319_HUMAN
NC score	0.016353 (rank : 1598)	θ value	8.99809 (rank : 1709)
Query Neighborhood Hits	1762	Target Neighborhood Hits	154	Shared Neighborhood Hits	44
SwissProt Accessions	Q5VV43, Q9UJC8, Q9Y4G7	Gene names	KIAA0319
Domain Architecture	No domain graphic available
Description	Protein KIAA0319 precursor.

FLIP1_HUMAN
NC score	0.016283 (rank : 1599)	θ value	0.813845 (rank : 1229)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1405	Shared Neighborhood Hits	154
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

NRX2A_HUMAN
NC score	0.016121 (rank : 1600)	θ value	1.06291 (rank : 1277)
Query Neighborhood Hits	1762	Target Neighborhood Hits	614	Shared Neighborhood Hits	153
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

TPO_MOUSE
NC score	0.016085 (rank : 1601)	θ value	1.81305 (rank : 1383)
Query Neighborhood Hits	1762	Target Neighborhood Hits	258	Shared Neighborhood Hits	70
SwissProt Accessions	P40226	Gene names	Thpo
Domain Architecture
Description	Thrombopoietin precursor (Megakaryocyte colony-stimulating factor) (Myeloproliferative leukemia virus oncogene ligand) (C-mpl ligand) (ML) (Megakaryocyte growth and development factor) (MGDF).

DLG5_HUMAN
NC score	0.015964 (rank : 1602)	θ value	0.21417 (rank : 1124)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1088	Shared Neighborhood Hits	152
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

TAB3_MOUSE
NC score	0.015828 (rank : 1603)	θ value	1.81305 (rank : 1379)
Query Neighborhood Hits	1762	Target Neighborhood Hits	273	Shared Neighborhood Hits	92
SwissProt Accessions	Q571K4	Gene names	Map3k7ip3, Kiaa4135, Tab3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3).

MRIP_MOUSE
NC score	0.015675 (rank : 1604)	θ value	8.99809 (rank : 1717)
Query Neighborhood Hits	1762	Target Neighborhood Hits	569	Shared Neighborhood Hits	64
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

GAK12_HUMAN
NC score	0.015634 (rank : 1605)	θ value	0.62314 (rank : 1199)
Query Neighborhood Hits	1762	Target Neighborhood Hits	374	Shared Neighborhood Hits	111
SwissProt Accessions	P63130, Q9UKI0	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q22 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K102 Gag protein) (HERV-K(III) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

BIN1_MOUSE
NC score	0.015633 (rank : 1606)	θ value	2.36792 (rank : 1394)
Query Neighborhood Hits	1762	Target Neighborhood Hits	283	Shared Neighborhood Hits	81
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

CECR2_HUMAN
NC score	0.015436 (rank : 1607)	θ value	0.163984 (rank : 1106)
Query Neighborhood Hits	1762	Target Neighborhood Hits	543	Shared Neighborhood Hits	140
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

ETV3_HUMAN
NC score	0.015432 (rank : 1608)	θ value	0.21417 (rank : 1125)
Query Neighborhood Hits	1762	Target Neighborhood Hits	312	Shared Neighborhood Hits	98
SwissProt Accessions	P41162, Q8TAC8, Q9BX30	Gene names	ETV3, METS, PE1
Domain Architecture	No domain graphic available
Description	ETS translocation variant 3 (ETS-domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor).

IL3RB_MOUSE
NC score	0.015416 (rank : 1609)	θ value	6.88961 (rank : 1623)
Query Neighborhood Hits	1762	Target Neighborhood Hits	355	Shared Neighborhood Hits	99
SwissProt Accessions	P26955	Gene names	Csf2rb, Aic2b, Csf2rb1, Il3rb1
Domain Architecture
Description	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen).

CRSP7_HUMAN
NC score	0.015233 (rank : 1610)	θ value	6.88961 (rank : 1610)
Query Neighborhood Hits	1762	Target Neighborhood Hits	247	Shared Neighborhood Hits	69
SwissProt Accessions	O95402	Gene names	CRSP7, ARC70
Domain Architecture
Description	CRSP complex subunit 7 (Cofactor required for Sp1 transcriptional activation subunit 7) (Transcriptional coactivator CRSP70) (Activator- recruited cofactor 70 kDa component) (ARC70).

LRRF1_HUMAN
NC score	0.015152 (rank : 1611)	θ value	2.36792 (rank : 1420)
Query Neighborhood Hits	1762	Target Neighborhood Hits	625	Shared Neighborhood Hits	75
SwissProt Accessions	Q32MZ4, O75766, O75799, Q32MZ5, Q53T49, Q6PKG2	Gene names	LRRFIP1, GCF2, TRIP
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII- interacting protein 1) (TAR RNA-interacting protein) (GC-binding factor 2).

LARP4_HUMAN
NC score	0.015067 (rank : 1612)	θ value	0.813845 (rank : 1236)
Query Neighborhood Hits	1762	Target Neighborhood Hits	69	Shared Neighborhood Hits	19
SwissProt Accessions	Q71RC2, Q5CZ97, Q96NF9	Gene names	LARP4
Domain Architecture	No domain graphic available
Description	La-related protein 4 (La ribonucleoprotein domain family member 4).

EVL_MOUSE
NC score	0.015058 (rank : 1613)	θ value	8.99809 (rank : 1697)
Query Neighborhood Hits	1762	Target Neighborhood Hits	203	Shared Neighborhood Hits	83
SwissProt Accessions	P70429, Q9ERU8	Gene names	Evl
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

INVS_HUMAN
NC score	0.014957 (rank : 1614)	θ value	0.125558 (rank : 1092)
Query Neighborhood Hits	1762	Target Neighborhood Hits	455	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Y283, Q5W0T6, Q8IVX8, Q9BRB9, Q9Y488, Q9Y498	Gene names	INVS, INV, NPHP2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning homolog) (Nephrocystin-2).

GAK10_HUMAN
NC score	0.014928 (rank : 1615)	θ value	0.813845 (rank : 1231)
Query Neighborhood Hits	1762	Target Neighborhood Hits	289	Shared Neighborhood Hits	98
SwissProt Accessions	P87889, P10263, P10264, Q69385, Q9UKH6	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_5q33.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K10 Gag protein) (HERV-K107 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

UBP42_HUMAN
NC score	0.014809 (rank : 1616)	θ value	0.365318 (rank : 1165)
Query Neighborhood Hits	1762	Target Neighborhood Hits	445	Shared Neighborhood Hits	131
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

SEPT9_MOUSE
NC score	0.014707 (rank : 1617)	θ value	5.27518 (rank : 1587)
Query Neighborhood Hits	1762	Target Neighborhood Hits	238	Shared Neighborhood Hits	78
SwissProt Accessions	Q80UG5, Q3URP2, Q80TM7, Q9QYX9	Gene names	Sept9, Kiaa0991, Sint1
Domain Architecture	No domain graphic available
Description	Septin-9 (SL3-3 integration site 1 protein).

FLIP1_MOUSE
NC score	0.014619 (rank : 1618)	θ value	0.279714 (rank : 1141)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1176	Shared Neighborhood Hits	145
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

NRX2B_HUMAN
NC score	0.014316 (rank : 1619)	θ value	1.06291 (rank : 1278)
Query Neighborhood Hits	1762	Target Neighborhood Hits	481	Shared Neighborhood Hits	141
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

SEN34_MOUSE
NC score	0.014194 (rank : 1620)	θ value	1.38821 (rank : 1335)
Query Neighborhood Hits	1762	Target Neighborhood Hits	158	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BMZ5, Q58EU2, Q99LV6, Q9CYW1	Gene names	Tsen34, Leng5, Sen34
Domain Architecture	No domain graphic available
Description	tRNA-splicing endonuclease subunit Sen34 (EC 3.1.27.9) (tRNA-intron endonuclease Sen34) (Leukocyte receptor cluster member 5 homolog).

NUFP1_HUMAN
NC score	0.014108 (rank : 1621)	θ value	0.279714 (rank : 1147)
Query Neighborhood Hits	1762	Target Neighborhood Hits	193	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UHK0, Q8WVM5, Q96SG1	Gene names	NUFIP1
Domain Architecture	No domain graphic available
Description	Nuclear fragile X mental retardation-interacting protein 1 (Nuclear FMRP-interacting protein 1).

SPRE3_HUMAN
NC score	0.014102 (rank : 1622)	θ value	0.0563607 (rank : 1062)
Query Neighborhood Hits	1762	Target Neighborhood Hits	65	Shared Neighborhood Hits	31
SwissProt Accessions	Q2MJR0	Gene names	SPRED3
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 3 (Spred-3).

TJAP1_MOUSE
NC score	0.013818 (rank : 1623)	θ value	6.88961 (rank : 1656)
Query Neighborhood Hits	1762	Target Neighborhood Hits	295	Shared Neighborhood Hits	41
SwissProt Accessions	Q9DCD5, Q8CFL7, Q8R5I2	Gene names	Tjap1, Pilt, Tjp4
Domain Architecture	No domain graphic available
Description	Tight junction-associated protein 1 (Tight junction protein 4) (Protein incorporated later into tight junctions).

CTND2_HUMAN
NC score	0.013693 (rank : 1624)	θ value	3.0926 (rank : 1453)
Query Neighborhood Hits	1762	Target Neighborhood Hits	333	Shared Neighborhood Hits	115
SwissProt Accessions	Q9UQB3, O00379, O15390, O43206, O43840, Q13589, Q9UM66, Q9UPM3	Gene names	CTNND2, NPRAP
Domain Architecture
Description	Catenin delta-2 (Delta-catenin) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) (GT24).

VGLL1_HUMAN
NC score	0.013596 (rank : 1625)	θ value	0.813845 (rank : 1251)
Query Neighborhood Hits	1762	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	Q99990	Gene names	VGLL1, TDU
Domain Architecture	No domain graphic available
Description	Transcription cofactor vestigial-like protein 1 (Vgl-1) (Protein TONDU).

ZO1_MOUSE
NC score	0.013489 (rank : 1626)	θ value	1.81305 (rank : 1388)
Query Neighborhood Hits	1762	Target Neighborhood Hits	453	Shared Neighborhood Hits	129
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

NASP_HUMAN
NC score	0.013410 (rank : 1627)	θ value	6.88961 (rank : 1635)
Query Neighborhood Hits	1762	Target Neighborhood Hits	709	Shared Neighborhood Hits	101
SwissProt Accessions	P49321, Q96A69, Q9BTW2	Gene names	NASP
Domain Architecture
Description	Nuclear autoantigenic sperm protein (NASP).

ASTL_HUMAN
NC score	0.013394 (rank : 1628)	θ value	5.27518 (rank : 1545)
Query Neighborhood Hits	1762	Target Neighborhood Hits	252	Shared Neighborhood Hits	103
SwissProt Accessions	Q6HA08	Gene names	ASTL
Domain Architecture	No domain graphic available
Description	Astacin-like metalloendopeptidase precursor (EC 3.4.-.-) (Oocyte astacin) (Ovastacin).

CO3A1_HUMAN
NC score	0.013367 (rank : 1629)	θ value	8.99809 (rank : 1682)
Query Neighborhood Hits	1762	Target Neighborhood Hits	452	Shared Neighborhood Hits	145
SwissProt Accessions	P02461, Q15112, Q16403, Q6LDB3, Q6LDJ2, Q6LDJ3, Q7KZ56	Gene names	COL3A1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

CBX2_HUMAN
NC score	0.013323 (rank : 1630)	θ value	1.38821 (rank : 1298)
Query Neighborhood Hits	1762	Target Neighborhood Hits	264	Shared Neighborhood Hits	83
SwissProt Accessions	Q14781, Q9BTB1	Gene names	CBX2
Domain Architecture	No domain graphic available
Description	Chromobox protein homolog 2.

CO1A1_MOUSE
NC score	0.013266 (rank : 1631)	θ value	5.27518 (rank : 1550)
Query Neighborhood Hits	1762	Target Neighborhood Hits	457	Shared Neighborhood Hits	154
SwissProt Accessions	P11087, Q53WT0, Q60635, Q61367, Q61427, Q63919, Q6PCL3, Q810J9	Gene names	Col1a1, Cola1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

RFIP1_MOUSE
NC score	0.013256 (rank : 1632)	θ value	1.06291 (rank : 1282)
Query Neighborhood Hits	1762	Target Neighborhood Hits	152	Shared Neighborhood Hits	44
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

CS021_HUMAN
NC score	0.013141 (rank : 1633)	θ value	6.88961 (rank : 1611)
Query Neighborhood Hits	1762	Target Neighborhood Hits	98	Shared Neighborhood Hits	36
SwissProt Accessions	Q8IVT2	Gene names	C19orf21
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf21.

GNAS1_HUMAN
NC score	0.013074 (rank : 1634)	θ value	0.0563607 (rank : 1058)
Query Neighborhood Hits	1762	Target Neighborhood Hits	278	Shared Neighborhood Hits	98
SwissProt Accessions	Q5JWF2, O75684, O75685, Q5JW67, Q5JWF1, Q9NY42	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

IQEC3_MOUSE
NC score	0.013006 (rank : 1635)	θ value	0.163984 (rank : 1108)
Query Neighborhood Hits	1762	Target Neighborhood Hits	274	Shared Neighborhood Hits	99
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

FBX41_MOUSE
NC score	0.012958 (rank : 1636)	θ value	4.03905 (rank : 1505)
Query Neighborhood Hits	1762	Target Neighborhood Hits	430	Shared Neighborhood Hits	62
SwissProt Accessions	Q6NS60, Q6P7W4, Q6ZPG1	Gene names	Fbxo41, D6Ertd538e, Kiaa1940
Domain Architecture	No domain graphic available
Description	F-box only protein 41.

GP137_HUMAN
NC score	0.012865 (rank : 1637)	θ value	6.88961 (rank : 1621)
Query Neighborhood Hits	1762	Target Neighborhood Hits	119	Shared Neighborhood Hits	29
SwissProt Accessions	Q14444, Q15074	Gene names	M11S1, GPIP137
Domain Architecture	No domain graphic available
Description	GPI-anchored protein p137 (p137GPI) (Membrane component chromosome 11 surface marker 1).

WAPL_MOUSE
NC score	0.012784 (rank : 1638)	θ value	0.62314 (rank : 1216)
Query Neighborhood Hits	1762	Target Neighborhood Hits	158	Shared Neighborhood Hits	31
SwissProt Accessions	Q65Z40, Q6ZQE9	Gene names	Wapal, Kiaa0261, Wapl
Domain Architecture	No domain graphic available
Description	Wings apart-like protein homolog (Dioxin-inducible factor 2) (DIF-2).

PRGC2_HUMAN
NC score	0.012727 (rank : 1639)	θ value	8.99809 (rank : 1734)
Query Neighborhood Hits	1762	Target Neighborhood Hits	272	Shared Neighborhood Hits	74
SwissProt Accessions	Q86YN6, Q86YN3, Q86YN4, Q86YN5, Q8N1N9, Q8TDE4, Q8TDE5	Gene names	PPARGC1B, PERC, PGC1, PGC1B, PPARGC1
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPAR gamma coactivator-1beta) (PGC-1-related estrogen receptor alpha coactivator) (PPARGC-1-beta) (PGC-1-beta).

GCP_HUMAN
NC score	0.012687 (rank : 1640)	θ value	0.62314 (rank : 1202)
Query Neighborhood Hits	1762	Target Neighborhood Hits	4	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NPF4	Gene names	OSGEP, GCPL1
Domain Architecture
Description	Probable O-sialoglycoprotein endopeptidase (EC 3.4.24.57) (hOSGEP).

CEP68_HUMAN
NC score	0.012609 (rank : 1641)	θ value	3.0926 (rank : 1450)
Query Neighborhood Hits	1762	Target Neighborhood Hits	128	Shared Neighborhood Hits	50
SwissProt Accessions	Q76N32, O60326, Q9BQ18, Q9UDM9	Gene names	CEP68, KIAA0582
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 68 kDa (Cep68 protein).

DYN1_MOUSE
NC score	0.012587 (rank : 1642)	θ value	0.813845 (rank : 1225)
Query Neighborhood Hits	1762	Target Neighborhood Hits	168	Shared Neighborhood Hits	72
SwissProt Accessions	P39053, Q61358, Q61359, Q61360, Q8JZZ4, Q9CSY7, Q9QXX1	Gene names	Dnm1, Dnm
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

SYTL1_HUMAN
NC score	0.012569 (rank : 1643)	θ value	4.03905 (rank : 1530)
Query Neighborhood Hits	1762	Target Neighborhood Hits	227	Shared Neighborhood Hits	62
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

PKCB1_HUMAN
NC score	0.012549 (rank : 1644)	θ value	1.06291 (rank : 1280)
Query Neighborhood Hits	1762	Target Neighborhood Hits	488	Shared Neighborhood Hits	96
SwissProt Accessions	Q9ULU4, Q13517, Q4JJ94, Q4JJ95, Q5TH09, Q6MZM1, Q8WXC5, Q9H1F3, Q9H1F4, Q9H1F5, Q9H1L8, Q9H1L9, Q9H2G5, Q9NYN3, Q9UIX6	Gene names	PRKCBP1, KIAA1125, RACK7, ZMYND8
Domain Architecture
Description	Protein kinase C-binding protein 1 (Rack7) (Cutaneous T-cell lymphoma- associated antigen se14-3) (CTCL tumor antigen se14-3) (Zinc finger MYND domain-containing protein 8).

MAGD4_HUMAN
NC score	0.012520 (rank : 1645)	θ value	0.0961366 (rank : 1076)
Query Neighborhood Hits	1762	Target Neighborhood Hits	338	Shared Neighborhood Hits	130
SwissProt Accessions	Q96JG8, Q8WXW4, Q9BQ84, Q9BYH3, Q9BYH4	Gene names	MAGED4, KIAA1859, MAGEE1
Domain Architecture
Description	Melanoma-associated antigen D4 (MAGE-D4 antigen) (MAGE-E1 antigen).

SPRE3_MOUSE
NC score	0.012452 (rank : 1646)	θ value	5.27518 (rank : 1590)
Query Neighborhood Hits	1762	Target Neighborhood Hits	111	Shared Neighborhood Hits	54
SwissProt Accessions	Q6P6N5, Q7TNJ8	Gene names	Spred3
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 3 (Spred-3).

ZIMP7_HUMAN
NC score	0.012433 (rank : 1647)	θ value	2.36792 (rank : 1443)
Query Neighborhood Hits	1762	Target Neighborhood Hits	290	Shared Neighborhood Hits	84
SwissProt Accessions	Q8NF64, O94790, Q659A8, Q6JKL5, Q8WTX8, Q96Q01, Q9BQH7	Gene names	ZIMP7, KIAA1886
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

ZIMP7_MOUSE
NC score	0.012399 (rank : 1648)	θ value	2.36792 (rank : 1444)
Query Neighborhood Hits	1762	Target Neighborhood Hits	566	Shared Neighborhood Hits	166
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

PDLI7_HUMAN
NC score	0.012356 (rank : 1649)	θ value	0.0736092 (rank : 1065)
Query Neighborhood Hits	1762	Target Neighborhood Hits	547	Shared Neighborhood Hits	136
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

ZC3H6_MOUSE
NC score	0.012333 (rank : 1650)	θ value	0.0252991 (rank : 1023)
Query Neighborhood Hits	1762	Target Neighborhood Hits	239	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BYK8, Q80UK3, Q8C1H1, Q9D604	Gene names	Zc3h6, Zc3hdc6
Domain Architecture
Description	Zinc finger CCCH domain-containing protein 6.

GCP_MOUSE
NC score	0.012239 (rank : 1651)	θ value	0.813845 (rank : 1232)
Query Neighborhood Hits	1762	Target Neighborhood Hits	4	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BWU5, Q99LN8	Gene names	Osgep
Domain Architecture
Description	Probable O-sialoglycoprotein endopeptidase (EC 3.4.24.57) (mOsgep).

MAGI2_HUMAN
NC score	0.012123 (rank : 1652)	θ value	1.06291 (rank : 1273)
Query Neighborhood Hits	1762	Target Neighborhood Hits	373	Shared Neighborhood Hits	91
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

RUNX2_HUMAN
NC score	0.012120 (rank : 1653)	θ value	1.38821 (rank : 1332)
Query Neighborhood Hits	1762	Target Neighborhood Hits	103	Shared Neighborhood Hits	39
SwissProt Accessions	Q13950, O14614, O14615, O95181	Gene names	RUNX2, AML3, CBFA1, OSF2, PEBP2A
Domain Architecture
Description	Runt-related transcription factor 2 (Core-binding factor, alpha 1 subunit) (CBF-alpha 1) (Acute myeloid leukemia 3 protein) (Oncogene AML-3) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEBP2-alpha A) (PEA2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) (Osteoblast- specific transcription factor 2) (OSF-2).

ZMYM3_HUMAN
NC score	0.012054 (rank : 1654)	θ value	2.36792 (rank : 1445)
Query Neighborhood Hits	1762	Target Neighborhood Hits	223	Shared Neighborhood Hits	67
SwissProt Accessions	Q14202, O15089	Gene names	ZMYM3, DXS6673E, KIAA0385, ZNF261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261).

UBXD2_HUMAN
NC score	0.012047 (rank : 1655)	θ value	6.88961 (rank : 1658)
Query Neighborhood Hits	1762	Target Neighborhood Hits	241	Shared Neighborhood Hits	29
SwissProt Accessions	Q92575, Q8IYM5	Gene names	UBXD2, KIAA0242, UBXDC1
Domain Architecture
Description	UBX domain-containing protein 2.

CIR_MOUSE
NC score	0.012032 (rank : 1656)	θ value	8.99809 (rank : 1680)
Query Neighborhood Hits	1762	Target Neighborhood Hits	255	Shared Neighborhood Hits	38
SwissProt Accessions	Q9DA19, Q3V2N9, Q4KL44, Q52KL9, Q5FW66	Gene names	Cir
Domain Architecture	No domain graphic available
Description	CBF1-interacting corepressor.

SOX13_HUMAN
NC score	0.012028 (rank : 1657)	θ value	3.0926 (rank : 1481)
Query Neighborhood Hits	1762	Target Neighborhood Hits	464	Shared Neighborhood Hits	126
SwissProt Accessions	Q9UN79, O95275, O95826, Q9UHW7	Gene names	SOX13
Domain Architecture
Description	SOX-13 protein (Type 1 diabetes autoantigen ICA12) (Islet cell antigen 12).

GOGA3_HUMAN
NC score	0.011934 (rank : 1658)	θ value	3.0926 (rank : 1461)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1317	Shared Neighborhood Hits	140
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

SPAG5_MOUSE
NC score	0.011869 (rank : 1659)	θ value	5.27518 (rank : 1589)
Query Neighborhood Hits	1762	Target Neighborhood Hits	612	Shared Neighborhood Hits	63
SwissProt Accessions	Q7TME2, Q8CH61	Gene names	Spag5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Mastrin) (Mitotic spindle-associated protein p126) (MAP126).

EVC_MOUSE
NC score	0.011844 (rank : 1660)	θ value	1.81305 (rank : 1360)
Query Neighborhood Hits	1762	Target Neighborhood Hits	80	Shared Neighborhood Hits	13
SwissProt Accessions	P57680	Gene names	Evc
Domain Architecture	No domain graphic available
Description	Ellis-van Creveld syndrome protein homolog.

RUNX2_MOUSE
NC score	0.011688 (rank : 1661)	θ value	1.38821 (rank : 1333)
Query Neighborhood Hits	1762	Target Neighborhood Hits	119	Shared Neighborhood Hits	44
SwissProt Accessions	Q08775, O35183, Q08776, Q9JLN0, Q9QUQ6, Q9QY29, Q9R0U4, Q9Z2J7	Gene names	Runx2, Aml3, Cbfa1, Osf2, Pebp2a
Domain Architecture
Description	Runt-related transcription factor 2 (Core-binding factor, alpha 1 subunit) (CBF-alpha 1) (Acute myeloid leukemia 3 protein) (Oncogene AML-3) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEBP2-alpha A) (PEA2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) (Osteoblast- specific transcription factor 2) (OSF-2).

EI2BD_HUMAN
NC score	0.011658 (rank : 1662)	θ value	0.813845 (rank : 1228)
Query Neighborhood Hits	1762	Target Neighborhood Hits	34	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UI10, Q5BJF4, Q9BUV9, Q9UBG4, Q9UIQ9, Q9UJ95	Gene names	EIF2B4, EIF2BD
Domain Architecture
Description	Translation initiation factor eIF-2B subunit delta (eIF-2B GDP-GTP exchange factor subunit delta).

BSCL2_HUMAN
NC score	0.011582 (rank : 1663)	θ value	1.38821 (rank : 1297)
Query Neighborhood Hits	1762	Target Neighborhood Hits	148	Shared Neighborhood Hits	31
SwissProt Accessions	Q96G97, Q96SV1, Q9BSQ0	Gene names	BSCL2
Domain Architecture	No domain graphic available
Description	Seipin (Bernardinelli-Seip congenital lipodystrophy type 2 protein).

GON2_HUMAN
NC score	0.011511 (rank : 1664)	θ value	2.36792 (rank : 1409)
Query Neighborhood Hits	1762	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	O43555, Q9BYN9, Q9BYP0	Gene names	GNRH2
Domain Architecture	No domain graphic available
Description	Progonadoliberin-2 precursor (Progonadoliberin II) [Contains: Gonadoliberin-2 (Gonadoliberin II) (Luteinizing hormone-releasing hormone II) (LH-RH II) (Gonadotropin-releasing hormone II) (GnRH II) (Luliberin II); GnRH-associated peptide 2 (GnRH-associated peptide II)].

CAC1G_HUMAN
NC score	0.011489 (rank : 1665)	θ value	5.27518 (rank : 1547)
Query Neighborhood Hits	1762	Target Neighborhood Hits	587	Shared Neighborhood Hits	184
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

HSF1_HUMAN
NC score	0.011489 (rank : 1666)	θ value	8.99809 (rank : 1704)
Query Neighborhood Hits	1762	Target Neighborhood Hits	163	Shared Neighborhood Hits	56
SwissProt Accessions	Q00613	Gene names	HSF1, HSTF1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

YAP1_HUMAN
NC score	0.011429 (rank : 1667)	θ value	1.81305 (rank : 1386)
Query Neighborhood Hits	1762	Target Neighborhood Hits	173	Shared Neighborhood Hits	56
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

EHMT2_MOUSE
NC score	0.011346 (rank : 1668)	θ value	0.813845 (rank : 1227)
Query Neighborhood Hits	1762	Target Neighborhood Hits	750	Shared Neighborhood Hits	163
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

USH1C_MOUSE
NC score	0.011271 (rank : 1669)	θ value	1.81305 (rank : 1385)
Query Neighborhood Hits	1762	Target Neighborhood Hits	557	Shared Neighborhood Hits	92
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

NFM_HUMAN
NC score	0.011004 (rank : 1670)	θ value	4.03905 (rank : 1517)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1328	Shared Neighborhood Hits	200
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

CSTFT_MOUSE
NC score	0.010918 (rank : 1671)	θ value	0.00665767 (rank : 967)
Query Neighborhood Hits	1762	Target Neighborhood Hits	356	Shared Neighborhood Hits	74
SwissProt Accessions	Q8C7E9, Q6A016, Q8BHH7, Q8C3W7, Q8R2Y1, Q9EPU3	Gene names	Cstf2t, Kiaa0689
Domain Architecture	No domain graphic available
Description	Cleavage stimulation factor 64 kDa subunit, tau variant (CSTF 64 kDa subunit, tau variant) (CF-1 64 kDa subunit, tau variant) (TauCstF-64).

EVI2B_HUMAN
NC score	0.010900 (rank : 1672)	θ value	8.99809 (rank : 1695)
Query Neighborhood Hits	1762	Target Neighborhood Hits	135	Shared Neighborhood Hits	47
SwissProt Accessions	P34910	Gene names	EVI2B, EVDB
Domain Architecture	No domain graphic available
Description	EVI2B protein precursor (Ecotropic viral integration site 2B protein).

SKI_HUMAN
NC score	0.010801 (rank : 1673)	θ value	6.88961 (rank : 1650)
Query Neighborhood Hits	1762	Target Neighborhood Hits	423	Shared Neighborhood Hits	48
SwissProt Accessions	P12755, Q5SYT7	Gene names	SKI
Domain Architecture
Description	Ski oncogene (C-ski).

RTN2_HUMAN
NC score	0.010770 (rank : 1674)	θ value	5.27518 (rank : 1585)
Query Neighborhood Hits	1762	Target Neighborhood Hits	59	Shared Neighborhood Hits	26
SwissProt Accessions	O75298, O60509, Q7RTM6, Q7RTN1, Q7RTN2	Gene names	RTN2, NSPL1
Domain Architecture
Description	Reticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like protein 1) (NSPLI).

UBQL3_HUMAN
NC score	0.010762 (rank : 1675)	θ value	1.06291 (rank : 1291)
Query Neighborhood Hits	1762	Target Neighborhood Hits	141	Shared Neighborhood Hits	48
SwissProt Accessions	Q9H347, Q9NRE0	Gene names	UBQLN3
Domain Architecture
Description	Ubiquilin-3.

PA24B_MOUSE
NC score	0.010745 (rank : 1676)	θ value	1.38821 (rank : 1328)
Query Neighborhood Hits	1762	Target Neighborhood Hits	102	Shared Neighborhood Hits	17
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

SOX6_HUMAN
NC score	0.010688 (rank : 1677)	θ value	0.813845 (rank : 1247)
Query Neighborhood Hits	1762	Target Neighborhood Hits	332	Shared Neighborhood Hits	65
SwissProt Accessions	P35712, Q9BXQ3, Q9BXQ4, Q9BXQ5, Q9H0I8	Gene names	SOX6
Domain Architecture
Description	Transcription factor SOX-6.

DIAP2_HUMAN
NC score	0.010571 (rank : 1678)	θ value	4.03905 (rank : 1502)
Query Neighborhood Hits	1762	Target Neighborhood Hits	342	Shared Neighborhood Hits	80
SwissProt Accessions	O60879, O60878, Q8WX06, Q8WX48, Q9UJL2	Gene names	DIAPH2, DIA
Domain Architecture
Description	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2).

IF16_HUMAN
NC score	0.010552 (rank : 1679)	θ value	4.03905 (rank : 1511)
Query Neighborhood Hits	1762	Target Neighborhood Hits	182	Shared Neighborhood Hits	68
SwissProt Accessions	Q16666, Q9UH78	Gene names	IFI16, IFNGIP1
Domain Architecture
Description	Gamma-interferon-inducible protein Ifi-16 (Interferon-inducible myeloid differentiation transcriptional activator) (IFI 16).

BAI1_HUMAN
NC score	0.010495 (rank : 1680)	θ value	6.88961 (rank : 1600)
Query Neighborhood Hits	1762	Target Neighborhood Hits	375	Shared Neighborhood Hits	120
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

ZO2_MOUSE
NC score	0.010451 (rank : 1681)	θ value	2.36792 (rank : 1446)
Query Neighborhood Hits	1762	Target Neighborhood Hits	296	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

SETX_HUMAN
NC score	0.010395 (rank : 1682)	θ value	8.99809 (rank : 1742)
Query Neighborhood Hits	1762	Target Neighborhood Hits	368	Shared Neighborhood Hits	84
SwissProt Accessions	Q7Z333, O75120, Q3KQX4, Q68DW5, Q6AZD7, Q7Z3J6, Q8WX33, Q9H9D1, Q9NVP9	Gene names	SETX, ALS4, KIAA0625, SCAR1
Domain Architecture
Description	Probable helicase senataxin (EC 3.6.1.-) (SEN1 homolog).

ELF4_MOUSE
NC score	0.010225 (rank : 1683)	θ value	0.0961366 (rank : 1073)
Query Neighborhood Hits	1762	Target Neighborhood Hits	191	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Z2U4	Gene names	Elf4, Mef
Domain Architecture	No domain graphic available
Description	ETS-related transcription factor Elf-4 (E74-like factor 4) (Myeloid Elf-1-like factor).

GAK1_HUMAN
NC score	0.010088 (rank : 1684)	θ value	4.03905 (rank : 1509)
Query Neighborhood Hits	1762	Target Neighborhood Hits	268	Shared Neighborhood Hits	81
SwissProt Accessions	P62683	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_12q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

HRSL5_HUMAN
NC score	0.009986 (rank : 1685)	θ value	1.06291 (rank : 1267)
Query Neighborhood Hits	1762	Target Neighborhood Hits	26	Shared Neighborhood Hits	8
SwissProt Accessions	Q96KN8	Gene names	HRASLS5, HRLP5
Domain Architecture
Description	HRAS-like suppressor 5 (H-rev107-like protein 5).

K0179_HUMAN
NC score	0.009982 (rank : 1686)	θ value	0.813845 (rank : 1234)
Query Neighborhood Hits	1762	Target Neighborhood Hits	81	Shared Neighborhood Hits	28
SwissProt Accessions	Q14684, Q8TBZ4	Gene names	KIAA0179
Domain Architecture
Description	Protein KIAA0179.

DBPA_HUMAN
NC score	0.009675 (rank : 1687)	θ value	3.0926 (rank : 1454)
Query Neighborhood Hits	1762	Target Neighborhood Hits	52	Shared Neighborhood Hits	19
SwissProt Accessions	P16989, Q14121, Q969N6	Gene names	CSDA, DBPA
Domain Architecture
Description	DNA-binding protein A (Cold shock domain-containing protein A) (Single-strand DNA-binding protein NF-GMB).

SOX6_MOUSE
NC score	0.009592 (rank : 1688)	θ value	6.88961 (rank : 1652)
Query Neighborhood Hits	1762	Target Neighborhood Hits	341	Shared Neighborhood Hits	58
SwissProt Accessions	P40645, Q62250, Q9QWS5	Gene names	Sox6, Sox-6
Domain Architecture
Description	Transcription factor SOX-6 (SOX-LZ).

TMM92_HUMAN
NC score	0.009568 (rank : 1689)	θ value	4.03905 (rank : 1532)
Query Neighborhood Hits	1762	Target Neighborhood Hits	6	Shared Neighborhood Hits	4
SwissProt Accessions	Q6UXU6, Q8NBF0	Gene names	TMEM92
Domain Architecture	No domain graphic available
Description	Transmembrane protein 92 precursor.

LARP1_HUMAN
NC score	0.009494 (rank : 1690)	θ value	5.27518 (rank : 1570)
Query Neighborhood Hits	1762	Target Neighborhood Hits	242	Shared Neighborhood Hits	56
SwissProt Accessions	Q6PKG0, O94836, Q8N4M2, Q8NB73, Q9UFD7	Gene names	LARP1, KIAA0731, LARP
Domain Architecture	No domain graphic available
Description	La-related protein 1 (La ribonucleoprotein domain family member 1).

CAC1A_HUMAN
NC score	0.009345 (rank : 1691)	θ value	0.0330416 (rank : 1025)
Query Neighborhood Hits	1762	Target Neighborhood Hits	387	Shared Neighborhood Hits	124
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

DBP_HUMAN
NC score	0.009276 (rank : 1692)	θ value	3.0926 (rank : 1455)
Query Neighborhood Hits	1762	Target Neighborhood Hits	136	Shared Neighborhood Hits	47
SwissProt Accessions	Q10586	Gene names	DBP
Domain Architecture
Description	D site-binding protein (Albumin D box-binding protein) (Albumin D- element-binding protein) (TAXREB302).

PP16A_HUMAN
NC score	0.009254 (rank : 1693)	θ value	0.21417 (rank : 1128)
Query Neighborhood Hits	1762	Target Neighborhood Hits	340	Shared Neighborhood Hits	45
SwissProt Accessions	Q96I34	Gene names	PPP1R16A, MYPT3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase- targeting subunit 3).

GAK7_HUMAN
NC score	0.009171 (rank : 1694)	θ value	8.99809 (rank : 1699)
Query Neighborhood Hits	1762	Target Neighborhood Hits	90	Shared Neighborhood Hits	37
SwissProt Accessions	Q96PI4, Q9QC08	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q23.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K18 Gag protein) (HERV-K110 Gag protein) (HERV-K(C1a) Gag protein) [Contains: Matrix protein].

PER2_MOUSE
NC score	0.009170 (rank : 1695)	θ value	8.99809 (rank : 1727)
Query Neighborhood Hits	1762	Target Neighborhood Hits	325	Shared Neighborhood Hits	91
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

EWS_HUMAN
NC score	0.009127 (rank : 1696)	θ value	1.38821 (rank : 1307)
Query Neighborhood Hits	1762	Target Neighborhood Hits	249	Shared Neighborhood Hits	54
SwissProt Accessions	Q01844, Q92635	Gene names	EWSR1, EWS
Domain Architecture
Description	RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein).

SSPO_MOUSE
NC score	0.009056 (rank : 1697)	θ value	8.99809 (rank : 1749)
Query Neighborhood Hits	1762	Target Neighborhood Hits	800	Shared Neighborhood Hits	116
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

DEN1A_HUMAN
NC score	0.009010 (rank : 1698)	θ value	2.36792 (rank : 1403)
Query Neighborhood Hits	1762	Target Neighborhood Hits	176	Shared Neighborhood Hits	66
SwissProt Accessions	Q8TEH3, Q5VWF0, Q8IVD6, Q9H796	Gene names	DENND1A
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 1A.

I20RA_MOUSE
NC score	0.008882 (rank : 1699)	θ value	5.27518 (rank : 1566)
Query Neighborhood Hits	1762	Target Neighborhood Hits	37	Shared Neighborhood Hits	12
SwissProt Accessions	Q6PHB0, Q8BW64	Gene names	Il20ra
Domain Architecture	No domain graphic available
Description	Interleukin-20 receptor alpha chain precursor (IL-20R-alpha) (IL- 20R1).

CTGE4_HUMAN
NC score	0.008866 (rank : 1700)	θ value	4.03905 (rank : 1500)
Query Neighborhood Hits	1762	Target Neighborhood Hits	393	Shared Neighborhood Hits	38
SwissProt Accessions	Q8IX94, O95046	Gene names	CTAGE4
Domain Architecture	No domain graphic available
Description	Cutaneous T-cell lymphoma-associated antigen 4 (cTAGE-4 protein).

SAHH3_HUMAN
NC score	0.008832 (rank : 1701)	θ value	0.0736092 (rank : 1066)
Query Neighborhood Hits	1762	Target Neighborhood Hits	23	Shared Neighborhood Hits	8
SwissProt Accessions	Q96HN2, O94917	Gene names	KIAA0828
Domain Architecture
Description	Putative adenosylhomocysteinase 3 (EC 3.3.1.1) (S-adenosyl-L- homocysteine hydrolase 3) (AdoHcyase 3).

K1688_HUMAN
NC score	0.008733 (rank : 1702)	θ value	1.38821 (rank : 1319)
Query Neighborhood Hits	1762	Target Neighborhood Hits	217	Shared Neighborhood Hits	61
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

MELPH_HUMAN
NC score	0.008648 (rank : 1703)	θ value	1.38821 (rank : 1322)
Query Neighborhood Hits	1762	Target Neighborhood Hits	145	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BV36, Q9HA71	Gene names	MLPH, SLAC2A
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Synaptotagmin-like protein 2a) (Slp homolog lacking C2 domains a).

SOX5_HUMAN
NC score	0.008614 (rank : 1704)	θ value	1.06291 (rank : 1288)
Query Neighborhood Hits	1762	Target Neighborhood Hits	219	Shared Neighborhood Hits	34
SwissProt Accessions	P35711, Q86UK8, Q8J017, Q8J018, Q8J019, Q8J020, Q8N1D9, Q8N7E0, Q8TEA4	Gene names	SOX5
Domain Architecture
Description	Transcription factor SOX-5.

TBC10_HUMAN
NC score	0.008550 (rank : 1705)	θ value	0.813845 (rank : 1249)
Query Neighborhood Hits	1762	Target Neighborhood Hits	64	Shared Neighborhood Hits	22
SwissProt Accessions	Q9BXI6, O76053, Q543A2	Gene names	TBC1D10A, EPI64, TBC1D10
Domain Architecture
Description	TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein).

XKR7_MOUSE
NC score	0.008539 (rank : 1706)	θ value	0.0736092 (rank : 1070)
Query Neighborhood Hits	1762	Target Neighborhood Hits	146	Shared Neighborhood Hits	42
SwissProt Accessions	Q5GH64	Gene names	Xkr7, Xrg7
Domain Architecture	No domain graphic available
Description	XK-related protein 7.

ENSA_HUMAN
NC score	0.008447 (rank : 1707)	θ value	1.06291 (rank : 1261)
Query Neighborhood Hits	1762	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	O43768, Q9NRZ0	Gene names	ENSA
Domain Architecture
Description	Alpha-endosulfine (ARPP-19e).

PGCA_MOUSE
NC score	0.008433 (rank : 1708)	θ value	8.99809 (rank : 1729)
Query Neighborhood Hits	1762	Target Neighborhood Hits	643	Shared Neighborhood Hits	134
SwissProt Accessions	Q61282, Q64021	Gene names	Agc1, Agc
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP).

CTGE6_HUMAN
NC score	0.008403 (rank : 1709)	θ value	0.47712 (rank : 1171)
Query Neighborhood Hits	1762	Target Neighborhood Hits	650	Shared Neighborhood Hits	58
SwissProt Accessions	Q86UF2	Gene names	CTAGE6
Domain Architecture	No domain graphic available
Description	Protein cTAGE-6 (cTAGE family member 6).

SOS1_MOUSE
NC score	0.008229 (rank : 1710)	θ value	8.99809 (rank : 1745)
Query Neighborhood Hits	1762	Target Neighborhood Hits	281	Shared Neighborhood Hits	84
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

TMUB1_HUMAN
NC score	0.008177 (rank : 1711)	θ value	1.81305 (rank : 1382)
Query Neighborhood Hits	1762	Target Neighborhood Hits	30	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BVT8	Gene names	TMUB1, C7orf21
Domain Architecture
Description	Transmembrane and ubiquitin-like domain-containing protein 1 (Ubiquitin-like protein SB144).

TBC10_MOUSE
NC score	0.008150 (rank : 1712)	θ value	1.06291 (rank : 1290)
Query Neighborhood Hits	1762	Target Neighborhood Hits	94	Shared Neighborhood Hits	30
SwissProt Accessions	P58802	Gene names	Tbc1d10a, Epi64, Tbc1d10
Domain Architecture
Description	TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein).

PGCA_HUMAN
NC score	0.008084 (rank : 1713)	θ value	8.99809 (rank : 1728)
Query Neighborhood Hits	1762	Target Neighborhood Hits	821	Shared Neighborhood Hits	188
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

GTF2I_HUMAN
NC score	0.008028 (rank : 1714)	θ value	1.38821 (rank : 1312)
Query Neighborhood Hits	1762	Target Neighborhood Hits	151	Shared Neighborhood Hits	36
SwissProt Accessions	P78347, O14743, O15359, O43546, O43588, O43589, Q9BSZ4	Gene names	GTF2I, BAP135, WBSCR6
Domain Architecture
Description	General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BTK-associated protein 135) (BAP-135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosome region 6 protein).

CTND2_MOUSE
NC score	0.007844 (rank : 1715)	θ value	6.88961 (rank : 1613)
Query Neighborhood Hits	1762	Target Neighborhood Hits	227	Shared Neighborhood Hits	74
SwissProt Accessions	O35927	Gene names	Ctnnd2, Catnd2, Nprap
Domain Architecture
Description	Catenin delta-2 (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin).

GP137_MOUSE
NC score	0.007814 (rank : 1716)	θ value	8.99809 (rank : 1702)
Query Neighborhood Hits	1762	Target Neighborhood Hits	102	Shared Neighborhood Hits	20
SwissProt Accessions	Q60865, Q60758, Q61620	Gene names	M11s1, Gpiap, Gpiap1, Gpip137
Domain Architecture	No domain graphic available
Description	GPI-anchored protein p137 (p137GPI).

MEN1_MOUSE
NC score	0.007765 (rank : 1717)	θ value	3.0926 (rank : 1472)
Query Neighborhood Hits	1762	Target Neighborhood Hits	31	Shared Neighborhood Hits	14
SwissProt Accessions	O88559	Gene names	Men1
Domain Architecture
Description	Menin.

DOCK4_HUMAN
NC score	0.007764 (rank : 1718)	θ value	1.38821 (rank : 1303)
Query Neighborhood Hits	1762	Target Neighborhood Hits	237	Shared Neighborhood Hits	82
SwissProt Accessions	Q8N1I0, O14584, O94824, Q8NB45	Gene names	DOCK4, KIAA0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

SOX5_MOUSE
NC score	0.007707 (rank : 1719)	θ value	1.06291 (rank : 1289)
Query Neighborhood Hits	1762	Target Neighborhood Hits	196	Shared Neighborhood Hits	30
SwissProt Accessions	P35710, O88184, O89018	Gene names	Sox5, Sox-5
Domain Architecture
Description	Transcription factor SOX-5.

JHD3B_MOUSE
NC score	0.007654 (rank : 1720)	θ value	3.0926 (rank : 1468)
Query Neighborhood Hits	1762	Target Neighborhood Hits	152	Shared Neighborhood Hits	61
SwissProt Accessions	Q91VY5, Q3UR22, Q6ZQ30, Q99K42	Gene names	Jmjd2b, Jhdm3b
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3B (EC 1.14.11.-) (Jumonji domain-containing protein 2B).

RECQ5_HUMAN
NC score	0.007592 (rank : 1721)	θ value	1.81305 (rank : 1372)
Query Neighborhood Hits	1762	Target Neighborhood Hits	390	Shared Neighborhood Hits	113
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

XKR5_MOUSE
NC score	0.007577 (rank : 1722)	θ value	0.62314 (rank : 1217)
Query Neighborhood Hits	1762	Target Neighborhood Hits	89	Shared Neighborhood Hits	18
SwissProt Accessions	Q5GH66	Gene names	Xkr5, Xrg5
Domain Architecture	No domain graphic available
Description	XK-related protein 5.

RFA1_MOUSE
NC score	0.007500 (rank : 1723)	θ value	0.813845 (rank : 1245)
Query Neighborhood Hits	1762	Target Neighborhood Hits	16	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VEE4, Q3TEJ8	Gene names	Rpa1
Domain Architecture	No domain graphic available
Description	Replication protein A 70 kDa DNA-binding subunit (RP-A) (RF-A) (Replication factor-A protein 1) (p70).

DDEF2_MOUSE
NC score	0.007379 (rank : 1724)	θ value	8.99809 (rank : 1687)
Query Neighborhood Hits	1762	Target Neighborhood Hits	625	Shared Neighborhood Hits	137
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DEND_HUMAN
NC score	0.007350 (rank : 1725)	θ value	5.27518 (rank : 1556)
Query Neighborhood Hits	1762	Target Neighborhood Hits	88	Shared Neighborhood Hits	30
SwissProt Accessions	O94850	Gene names	DDN, KIAA0749
Domain Architecture	No domain graphic available
Description	Dendrin.

CO5A1_MOUSE
NC score	0.007289 (rank : 1726)	θ value	4.03905 (rank : 1498)
Query Neighborhood Hits	1762	Target Neighborhood Hits	419	Shared Neighborhood Hits	146
SwissProt Accessions	O88207	Gene names	Col5a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(V) chain precursor.

FRS3_MOUSE
NC score	0.007286 (rank : 1727)	θ value	0.62314 (rank : 1198)
Query Neighborhood Hits	1762	Target Neighborhood Hits	168	Shared Neighborhood Hits	56
SwissProt Accessions	Q91WJ0	Gene names	Frs3, Frs2b
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (FRS2-beta).

EWS_MOUSE
NC score	0.007284 (rank : 1728)	θ value	1.38821 (rank : 1308)
Query Neighborhood Hits	1762	Target Neighborhood Hits	271	Shared Neighborhood Hits	54
SwissProt Accessions	Q61545	Gene names	Ewsr1, Ews, Ewsh
Domain Architecture
Description	RNA-binding protein EWS.

SAHH3_MOUSE
NC score	0.007272 (rank : 1729)	θ value	2.36792 (rank : 1435)
Query Neighborhood Hits	1762	Target Neighborhood Hits	35	Shared Neighborhood Hits	16
SwissProt Accessions	Q68FL4, Q8BIH1	Gene names
Domain Architecture	No domain graphic available
Description	Putative adenosylhomocysteinase 3 (EC 3.3.1.1) (S-adenosyl-L- homocysteine hydrolase 3) (AdoHcyase 3).

CO5A1_HUMAN
NC score	0.007262 (rank : 1730)	θ value	3.0926 (rank : 1452)
Query Neighborhood Hits	1762	Target Neighborhood Hits	434	Shared Neighborhood Hits	145
SwissProt Accessions	P20908, Q15094, Q5SUX4	Gene names	COL5A1
Domain Architecture
Description	Collagen alpha-1(V) chain precursor.

SAPS2_MOUSE
NC score	0.007246 (rank : 1731)	θ value	1.38821 (rank : 1334)
Query Neighborhood Hits	1762	Target Neighborhood Hits	47	Shared Neighborhood Hits	15
SwissProt Accessions	Q8R3Q2, Q9CXB7	Gene names	Saps2, Kiaa0685
Domain Architecture
Description	SAPS domain family member 2.

CMTA1_HUMAN
NC score	0.007197 (rank : 1732)	θ value	2.36792 (rank : 1399)
Query Neighborhood Hits	1762	Target Neighborhood Hits	217	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y6Y1, Q5VUE1	Gene names	CAMTA1, KIAA0833
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 1.

DBPA_MOUSE
NC score	0.007089 (rank : 1733)	θ value	8.99809 (rank : 1686)
Query Neighborhood Hits	1762	Target Neighborhood Hits	64	Shared Neighborhood Hits	25
SwissProt Accessions	Q9JKB3, Q80WG4, Q9EQF7, Q9EQF8	Gene names	Csda, Msy4, Ybx3
Domain Architecture	No domain graphic available
Description	DNA-binding protein A (Cold shock domain-containing protein A) (Y-box protein 3).

CAC1H_HUMAN
NC score	0.006960 (rank : 1734)	θ value	5.27518 (rank : 1548)
Query Neighborhood Hits	1762	Target Neighborhood Hits	307	Shared Neighborhood Hits	102
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

RHBD3_HUMAN
NC score	0.006864 (rank : 1735)	θ value	1.81305 (rank : 1374)
Query Neighborhood Hits	1762	Target Neighborhood Hits	15	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y3P4, Q6I9X3, Q9UGQ7	Gene names	RHBDD3, C22orf3
Domain Architecture
Description	Rhomboid domain-containing protein 3.

GGA1_HUMAN
NC score	0.006740 (rank : 1736)	θ value	8.99809 (rank : 1700)
Query Neighborhood Hits	1762	Target Neighborhood Hits	169	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UJY5, Q5TG07, Q9BW94, Q9UG00, Q9UGW0, Q9UGW1	Gene names	GGA1
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein 1).

RPGF1_HUMAN
NC score	0.006706 (rank : 1737)	θ value	0.62314 (rank : 1211)
Query Neighborhood Hits	1762	Target Neighborhood Hits	262	Shared Neighborhood Hits	73
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

FGFP2_HUMAN
NC score	0.006698 (rank : 1738)	θ value	3.0926 (rank : 1458)
Query Neighborhood Hits	1762	Target Neighborhood Hits	12	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BYJ0	Gene names	FGFBP2, KSP37
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor-binding protein 2 precursor (FGF-binding protein 2) (FGF-BP2) (FGFBP-2) (37 kDa killer-specific secretory protein) (Ksp37) (HBp17-related protein) (HBp17-RP).

BCL3_MOUSE
NC score	0.006695 (rank : 1739)	θ value	0.813845 (rank : 1220)
Query Neighborhood Hits	1762	Target Neighborhood Hits	388	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z2F6	Gene names	Bcl3
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 3-encoded protein homolog (Protein Bcl-3).

K1688_MOUSE
NC score	0.006405 (rank : 1740)	θ value	4.03905 (rank : 1514)
Query Neighborhood Hits	1762	Target Neighborhood Hits	188	Shared Neighborhood Hits	52
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

SPHK2_MOUSE
NC score	0.006338 (rank : 1741)	θ value	1.81305 (rank : 1378)
Query Neighborhood Hits	1762	Target Neighborhood Hits	78	Shared Neighborhood Hits	27
SwissProt Accessions	Q9JIA7, Q91VA9, Q9DBH6	Gene names	Sphk2
Domain Architecture
Description	Sphingosine kinase 2 (EC 2.7.1.-) (SK 2) (SPK 2).

PCIF1_HUMAN
NC score	0.006305 (rank : 1742)	θ value	6.88961 (rank : 1638)
Query Neighborhood Hits	1762	Target Neighborhood Hits	92	Shared Neighborhood Hits	29
SwissProt Accessions	Q9H4Z3, Q9NT85	Gene names	PCIF1, C20orf67
Domain Architecture
Description	Phosphorylated CTD-interacting factor 1.

COFA1_HUMAN
NC score	0.006240 (rank : 1743)	θ value	8.99809 (rank : 1683)
Query Neighborhood Hits	1762	Target Neighborhood Hits	292	Shared Neighborhood Hits	95
SwissProt Accessions	P39059, Q5T6J4, Q9Y4W4	Gene names	COL15A1
Domain Architecture
Description	Collagen alpha-1(XV) chain precursor [Contains: Endostatin (Endostatin-XV) (Restin) (Related to endostatin)].

BRD8_HUMAN
NC score	0.006066 (rank : 1744)	θ value	6.88961 (rank : 1603)
Query Neighborhood Hits	1762	Target Neighborhood Hits	292	Shared Neighborhood Hits	55
SwissProt Accessions	Q9H0E9, O43178, Q15355, Q59GN0, Q969M9	Gene names	BRD8, SMAP
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8 (p120) (Skeletal muscle abundant protein) (Thyroid hormone receptor coactivating protein 120kDa) (TrCP120).

3MG_HUMAN
NC score	0.005962 (rank : 1745)	θ value	5.27518 (rank : 1540)
Query Neighborhood Hits	1762	Target Neighborhood Hits	32	Shared Neighborhood Hits	15
SwissProt Accessions	P29372, Q13770, Q15275, Q15961, Q96BZ6, Q96S33, Q9NNX5	Gene names	MPG, AAG, ANPG, MID1
Domain Architecture
Description	DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-methyladenine DNA glycosidase) (ADPG) (3-alkyladenine DNA glycosylase) (N-methylpurine- DNA glycosylase).

ANR43_HUMAN
NC score	0.005938 (rank : 1746)	θ value	5.27518 (rank : 1543)
Query Neighborhood Hits	1762	Target Neighborhood Hits	209	Shared Neighborhood Hits	26
SwissProt Accessions	Q2M3V2, Q8NAE7	Gene names	ANKRD43
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 43.

WFS1_HUMAN
NC score	0.005898 (rank : 1747)	θ value	6.88961 (rank : 1661)
Query Neighborhood Hits	1762	Target Neighborhood Hits	42	Shared Neighborhood Hits	18
SwissProt Accessions	O76024, Q8N6I3, Q9UNW6	Gene names	WFS1
Domain Architecture	No domain graphic available
Description	Wolframin.

CSTF2_HUMAN
NC score	0.005875 (rank : 1748)	θ value	0.00665767 (rank : 966)
Query Neighborhood Hits	1762	Target Neighborhood Hits	296	Shared Neighborhood Hits	49
SwissProt Accessions	P33240, Q5H951, Q6LA74, Q8N502	Gene names	CSTF2
Domain Architecture
Description	Cleavage stimulation factor 64 kDa subunit (CSTF 64 kDa subunit) (CF-1 64 kDa subunit) (CstF-64).

PP16A_MOUSE
NC score	0.005859 (rank : 1749)	θ value	4.03905 (rank : 1522)
Query Neighborhood Hits	1762	Target Neighborhood Hits	318	Shared Neighborhood Hits	31
SwissProt Accessions	Q923M0, Q4V9Z1	Gene names	Ppp1r16a, Mypt3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase targeting subunit 3).

CAC1B_HUMAN
NC score	0.005812 (rank : 1750)	θ value	4.03905 (rank : 1496)
Query Neighborhood Hits	1762	Target Neighborhood Hits	257	Shared Neighborhood Hits	76
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

WFS1_MOUSE
NC score	0.005768 (rank : 1751)	θ value	8.99809 (rank : 1758)
Query Neighborhood Hits	1762	Target Neighborhood Hits	49	Shared Neighborhood Hits	21
SwissProt Accessions	P56695, Q9Z276	Gene names	Wfs1
Domain Architecture	No domain graphic available
Description	Wolframin.

ANK1_HUMAN
NC score	0.005761 (rank : 1752)	θ value	8.99809 (rank : 1670)
Query Neighborhood Hits	1762	Target Neighborhood Hits	416	Shared Neighborhood Hits	54
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

MEF2A_HUMAN
NC score	0.005713 (rank : 1753)	θ value	8.99809 (rank : 1714)
Query Neighborhood Hits	1762	Target Neighborhood Hits	69	Shared Neighborhood Hits	28
SwissProt Accessions	Q02078, O43814, Q14223, Q14224, Q96D14	Gene names	MEF2A, MEF2
Domain Architecture
Description	Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1).

PHF8_HUMAN
NC score	0.005662 (rank : 1754)	θ value	0.0252991 (rank : 1018)
Query Neighborhood Hits	1762	Target Neighborhood Hits	105	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UPP1, Q5H9U5, Q5VUJ4, Q7Z6D4, Q9HAH2	Gene names	PHF8, KIAA1111, ZNF422
Domain Architecture	No domain graphic available
Description	PHD finger protein 8.

CAC1B_MOUSE
NC score	0.005612 (rank : 1755)	θ value	0.47712 (rank : 1169)
Query Neighborhood Hits	1762	Target Neighborhood Hits	351	Shared Neighborhood Hits	95
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

BANK1_HUMAN
NC score	0.005609 (rank : 1756)	θ value	1.81305 (rank : 1352)
Query Neighborhood Hits	1762	Target Neighborhood Hits	44	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NDB2, Q8N5K8, Q8NB56, Q8WYN5, Q9NWP2	Gene names	BANK1
Domain Architecture	No domain graphic available
Description	B-cell scaffold protein with ankyrin repeats.

CDC73_HUMAN
NC score	0.005541 (rank : 1757)	θ value	8.99809 (rank : 1677)
Query Neighborhood Hits	1762	Target Neighborhood Hits	38	Shared Neighborhood Hits	15
SwissProt Accessions	Q6P1J9, Q6PK51, Q96A07, Q9H245, Q9H5L7	Gene names	CDC73, C1orf28, HRPT2
Domain Architecture	No domain graphic available
Description	Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein).

CDC73_MOUSE
NC score	0.005541 (rank : 1758)	θ value	8.99809 (rank : 1678)
Query Neighborhood Hits	1762	Target Neighborhood Hits	38	Shared Neighborhood Hits	15
SwissProt Accessions	Q8JZM7	Gene names	Cdc73
Domain Architecture	No domain graphic available
Description	Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein homolog).

CND1_HUMAN
NC score	0.005502 (rank : 1759)	θ value	1.38821 (rank : 1302)
Query Neighborhood Hits	1762	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	Q15021, Q8N6U3	Gene names	NCAPD2, CAPD2, CNAP1, KIAA0159
Domain Architecture
Description	Condensin complex subunit 1 (Non-SMC condensin I complex subunit D2) (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (XCAP-D2 homolog).

TAF9_MOUSE
NC score	0.005446 (rank : 1760)	θ value	2.36792 (rank : 1437)
Query Neighborhood Hits	1762	Target Neighborhood Hits	69	Shared Neighborhood Hits	23
SwissProt Accessions	Q8VI33, Q32P09, Q80XS3, Q9CV61	Gene names	Taf9, Taf2g
Domain Architecture
Description	Transcription initiation factor TFIID subunit 9 (Transcription initiation factor TFIID 31 kDa subunit) (TAFII-31) (TAFII-32) (TAFII32).

CLCN1_HUMAN
NC score	0.005393 (rank : 1761)	θ value	0.0563607 (rank : 1056)
Query Neighborhood Hits	1762	Target Neighborhood Hits	89	Shared Neighborhood Hits	30
SwissProt Accessions	P35523	Gene names	CLCN1, CLC1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

NUP98_HUMAN
NC score	0.005322 (rank : 1762)	θ value	8.99809 (rank : 1721)
Query Neighborhood Hits	1762	Target Neighborhood Hits	81	Shared Neighborhood Hits	24
SwissProt Accessions	P52948, Q8IUT2, Q8WYB0, Q96E54, Q9H3Q4, Q9NT02, Q9UF57, Q9UHX0, Q9Y6J4, Q9Y6J5	Gene names	NUP98
Domain Architecture
Description	Nuclear pore complex protein Nup98-Nup96 precursor [Contains: Nuclear pore complex protein Nup98 (Nucleoporin Nup98) (98 kDa nucleoporin); Nuclear pore complex protein Nup96 (Nucleoporin Nup96) (96 kDa nucleoporin)].

CI037_HUMAN
NC score	0.005310 (rank : 1763)	θ value	8.99809 (rank : 1679)
Query Neighborhood Hits	1762	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H2J1, Q5T368	Gene names	C9orf37
Domain Architecture	No domain graphic available
Description	Protein C9orf37.

OTU7A_HUMAN
NC score	0.005269 (rank : 1764)	θ value	4.03905 (rank : 1519)
Query Neighborhood Hits	1762	Target Neighborhood Hits	74	Shared Neighborhood Hits	19
SwissProt Accessions	Q8TE49, Q8IWK5	Gene names	OTUD7A, C15orf16, OTUD7
Domain Architecture	No domain graphic available
Description	OTU domain-containing protein 7A (EC 3.-.-.-) (Zinc finger protein Cezanne 2).

CAC1H_MOUSE
NC score	0.005177 (rank : 1765)	θ value	6.88961 (rank : 1604)
Query Neighborhood Hits	1762	Target Neighborhood Hits	230	Shared Neighborhood Hits	73
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

CE110_MOUSE
NC score	0.004986 (rank : 1766)	θ value	6.88961 (rank : 1606)
Query Neighborhood Hits	1762	Target Neighborhood Hits	170	Shared Neighborhood Hits	24
SwissProt Accessions	Q7TSH4, Q6A072	Gene names	Cep110, Cp110, Kiaa0419
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 110 kDa (Cep110 protein).

CSPG4_HUMAN
NC score	0.004918 (rank : 1767)	θ value	6.88961 (rank : 1612)
Query Neighborhood Hits	1762	Target Neighborhood Hits	112	Shared Neighborhood Hits	18
SwissProt Accessions	Q6UVK1, Q92675	Gene names	CSPG4, MCSP
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 4 precursor (Chondroitin sulfate proteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan) (Melanoma-associated chondroitin sulfate proteoglycan).

ATS14_HUMAN
NC score	0.004878 (rank : 1768)	θ value	1.81305 (rank : 1350)
Query Neighborhood Hits	1762	Target Neighborhood Hits	382	Shared Neighborhood Hits	99
SwissProt Accessions	Q8WXS8, Q8TE55, Q8TEY8	Gene names	ADAMTS14
Domain Architecture
Description	ADAMTS-14 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 14) (ADAM-TS 14) (ADAM-TS14).

SORC2_HUMAN
NC score	0.004811 (rank : 1769)	θ value	1.38821 (rank : 1341)
Query Neighborhood Hits	1762	Target Neighborhood Hits	66	Shared Neighborhood Hits	29
SwissProt Accessions	Q96PQ0, Q9P2L7	Gene names	SORCS2, KIAA1329
Domain Architecture
Description	VPS10 domain-containing receptor SorCS2 precursor.

CSTFT_HUMAN
NC score	0.004810 (rank : 1770)	θ value	0.163984 (rank : 1107)
Query Neighborhood Hits	1762	Target Neighborhood Hits	292	Shared Neighborhood Hits	45
SwissProt Accessions	Q9H0L4, O75174, Q53HK6, Q7LGE8, Q8N6T1	Gene names	CSTF2T, KIAA0689
Domain Architecture	No domain graphic available
Description	Cleavage stimulation factor 64 kDa subunit, tau variant (CSTF 64 kDa subunit, tau variant) (CF-1 64 kDa subunit, tau variant) (TauCstF-64).

STAT2_MOUSE
NC score	0.004756 (rank : 1771)	θ value	5.27518 (rank : 1591)
Query Neighborhood Hits	1762	Target Neighborhood Hits	175	Shared Neighborhood Hits	52
SwissProt Accessions	Q9WVL2, Q64188, Q64189, Q64250	Gene names	Stat2
Domain Architecture
Description	Signal transducer and activator of transcription 2.

DDFL1_HUMAN
NC score	0.004755 (rank : 1772)	θ value	0.365318 (rank : 1154)
Query Neighborhood Hits	1762	Target Neighborhood Hits	353	Shared Neighborhood Hits	47
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

PO6F1_MOUSE
NC score	0.004743 (rank : 1773)	θ value	2.36792 (rank : 1429)
Query Neighborhood Hits	1762	Target Neighborhood Hits	581	Shared Neighborhood Hits	114
SwissProt Accessions	Q07916, Q91XK3	Gene names	Pou6f1, Emb
Domain Architecture
Description	POU domain, class 6, transcription factor 1 (Octamer-binding transcription factor EMB) (Transcription regulatory protein MCP-1).

DOK1_HUMAN
NC score	0.004674 (rank : 1774)	θ value	4.03905 (rank : 1503)
Query Neighborhood Hits	1762	Target Neighborhood Hits	85	Shared Neighborhood Hits	27
SwissProt Accessions	Q99704, O43204, Q9UHG6	Gene names	DOK1
Domain Architecture
Description	Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62).

IRX5_HUMAN
NC score	0.004674 (rank : 1775)	θ value	5.27518 (rank : 1568)
Query Neighborhood Hits	1762	Target Neighborhood Hits	362	Shared Neighborhood Hits	83
SwissProt Accessions	P78411, P78416, Q7Z2E1	Gene names	IRX5, IRX2A, IRXB2
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-5 (Iroquois homeobox protein 5) (Homeodomain protein IRXB2) (IRX-2A).

TBCD2_HUMAN
NC score	0.004616 (rank : 1776)	θ value	2.36792 (rank : 1439)
Query Neighborhood Hits	1762	Target Neighborhood Hits	419	Shared Neighborhood Hits	69
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

K0226_HUMAN
NC score	0.004566 (rank : 1777)	θ value	6.88961 (rank : 1625)
Query Neighborhood Hits	1762	Target Neighborhood Hits	92	Shared Neighborhood Hits	26
SwissProt Accessions	Q92622	Gene names	KIAA0226
Domain Architecture	No domain graphic available
Description	Protein KIAA0226.

DNM3B_MOUSE
NC score	0.004303 (rank : 1778)	θ value	2.36792 (rank : 1404)
Query Neighborhood Hits	1762	Target Neighborhood Hits	61	Shared Neighborhood Hits	6
SwissProt Accessions	O88509, O88510, O88511	Gene names	Dnmt3b
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3B (EC 2.1.1.37) (Dnmt3b) (DNA methyltransferase MmuIIIB) (DNA MTase MmuIIIB) (M.MmuIIIB).

QSCN6_HUMAN
NC score	0.004259 (rank : 1779)	θ value	3.0926 (rank : 1479)
Query Neighborhood Hits	1762	Target Neighborhood Hits	98	Shared Neighborhood Hits	24
SwissProt Accessions	O00391, Q59G29, Q5T2X0, Q8TDL6, Q8WVP4	Gene names	QSCN6, QSOX1
Domain Architecture	No domain graphic available
Description	Sulfhydryl oxidase 1 precursor (EC 1.8.3.2) (Quiescin Q6) (hQSOX).

PRR3_MOUSE
NC score	0.004134 (rank : 1780)	θ value	4.03905 (rank : 1523)
Query Neighborhood Hits	1762	Target Neighborhood Hits	39	Shared Neighborhood Hits	8
SwissProt Accessions	Q811B5, Q91YI5	Gene names	Prr3, Cat56
Domain Architecture	No domain graphic available
Description	Proline-rich protein 3 (MHC class I region proline-rich protein CAT56).

VMD2_HUMAN
NC score	0.004118 (rank : 1781)	θ value	0.365318 (rank : 1167)
Query Neighborhood Hits	1762	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	O76090, O75904, Q8IUR9, Q8IZ80	Gene names	VMD2
Domain Architecture
Description	Bestrophin-1 (Vitelliform macular dystrophy protein 2) (TU15B).

ENSA_MOUSE
NC score	0.004105 (rank : 1782)	θ value	8.99809 (rank : 1691)
Query Neighborhood Hits	1762	Target Neighborhood Hits	10	Shared Neighborhood Hits	5
SwissProt Accessions	P60840, Q9CQZ9, Q9Z0G1	Gene names	Ensa
Domain Architecture
Description	Alpha-endosulfine (ARPP-19e).

RTN2_MOUSE
NC score	0.004049 (rank : 1783)	θ value	8.99809 (rank : 1740)
Query Neighborhood Hits	1762	Target Neighborhood Hits	48	Shared Neighborhood Hits	16
SwissProt Accessions	O70622, O70620	Gene names	Rtn2, Nspl1
Domain Architecture
Description	Reticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like protein 1) (NSPLI).

RM46_MOUSE
NC score	0.004040 (rank : 1784)	θ value	8.99809 (rank : 1739)
Query Neighborhood Hits	1762	Target Neighborhood Hits	22	Shared Neighborhood Hits	6
SwissProt Accessions	Q9EQI8	Gene names	Mrpl46
Domain Architecture	No domain graphic available
Description	39S ribosomal protein L46, mitochondrial precursor (L46mt) (MRP-L46).

CABL1_MOUSE
NC score	0.004000 (rank : 1785)	θ value	2.36792 (rank : 1395)
Query Neighborhood Hits	1762	Target Neighborhood Hits	31	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ESJ1, Q9EPR8	Gene names	Cables1, Cables
Domain Architecture	No domain graphic available
Description	CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1).

MEF2B_MOUSE
NC score	0.003930 (rank : 1786)	θ value	8.99809 (rank : 1715)
Query Neighborhood Hits	1762	Target Neighborhood Hits	218	Shared Neighborhood Hits	63
SwissProt Accessions	O55087, O55088, O55089, O55090, O55231, Q61843	Gene names	Mef2b
Domain Architecture
Description	Myocyte-specific enhancer factor 2B.

ECT2_MOUSE
NC score	0.003929 (rank : 1787)	θ value	1.38821 (rank : 1304)
Query Neighborhood Hits	1762	Target Neighborhood Hits	98	Shared Neighborhood Hits	7
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

TIF1G_MOUSE
NC score	0.003846 (rank : 1788)	θ value	8.99809 (rank : 1755)
Query Neighborhood Hits	1762	Target Neighborhood Hits	498	Shared Neighborhood Hits	106
SwissProt Accessions	Q99PP7, Q6SI71, Q6ZPX5	Gene names	Trim33, Kiaa1113
Domain Architecture	No domain graphic available
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33).

CO2A1_HUMAN
NC score	0.003822 (rank : 1789)	θ value	6.88961 (rank : 1609)
Query Neighborhood Hits	1762	Target Neighborhood Hits	486	Shared Neighborhood Hits	149
SwissProt Accessions	P02458, Q12985, Q14009, Q14044, Q14046, Q14056, Q14058, Q16672, Q6LBY1, Q6LBY2, Q6LBY3, Q99227, Q9UE38, Q9UE39, Q9UE40, Q9UE41, Q9UE42, Q9UE43	Gene names	COL2A1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

HAIR_MOUSE
NC score	0.003674 (rank : 1790)	θ value	3.0926 (rank : 1463)
Query Neighborhood Hits	1762	Target Neighborhood Hits	97	Shared Neighborhood Hits	23
SwissProt Accessions	Q61645, Q80Y47	Gene names	Hr
Domain Architecture
Description	Protein hairless.

B4GN4_MOUSE
NC score	0.003672 (rank : 1791)	θ value	4.03905 (rank : 1494)
Query Neighborhood Hits	1762	Target Neighborhood Hits	129	Shared Neighborhood Hits	33
SwissProt Accessions	Q766D5, Q8CHV2	Gene names	B4galnt4
Domain Architecture	No domain graphic available
Description	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferase 1 (EC 2.4.1.244) (NGalNAc-T1) (Beta- 1,4-N-acetylgalactosaminyltransferase IV) (Beta4GalNAc-T4) (Beta4GalNAcT4).

NECP2_MOUSE
NC score	0.003649 (rank : 1792)	θ value	5.27518 (rank : 1574)
Query Neighborhood Hits	1762	Target Neighborhood Hits	16	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D1J1, Q3U1M1, Q9CV41	Gene names	Necap2
Domain Architecture	No domain graphic available
Description	Adaptin ear-binding coat-associated protein 2 (NECAP-2).

NFAM1_HUMAN
NC score	0.003639 (rank : 1793)	θ value	6.88961 (rank : 1636)
Query Neighborhood Hits	1762	Target Neighborhood Hits	14	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NET5, Q8IUY8, Q8TEM8	Gene names	NFAM1, CNAIP
Domain Architecture	No domain graphic available
Description	NFAT activation molecule 1 precursor (Calcineurin/NFAT-activating ITAM-containing protein) (NFAT-activating protein with ITAM motif 1).

PDLI7_MOUSE
NC score	0.003620 (rank : 1794)	θ value	6.88961 (rank : 1641)
Query Neighborhood Hits	1762	Target Neighborhood Hits	279	Shared Neighborhood Hits	40
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

MICA1_HUMAN
NC score	0.003530 (rank : 1795)	θ value	6.88961 (rank : 1629)
Query Neighborhood Hits	1762	Target Neighborhood Hits	279	Shared Neighborhood Hits	69
SwissProt Accessions	Q8TDZ2, Q7Z633, Q8IVS9, Q96G47, Q9H6X6, Q9H7I0, Q9HAA1, Q9UFF7	Gene names	MICAL1, MICAL, NICAL
Domain Architecture
Description	NEDD9-interacting protein with calponin homology and LIM domains (Molecule interacting with CasL protein 1).

JHD2A_HUMAN
NC score	0.003485 (rank : 1796)	θ value	3.0926 (rank : 1467)
Query Neighborhood Hits	1762	Target Neighborhood Hits	118	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y4C1, Q53S72, Q68D47, Q68UT9, Q6N050, Q8IY08	Gene names	JMJD1A, JHDM2A, JMJD1, KIAA0742
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2A (EC 1.14.11.-) (Jumonji domain-containing protein 1A).

ETV5_MOUSE
NC score	0.003425 (rank : 1797)	θ value	4.03905 (rank : 1504)
Query Neighborhood Hits	1762	Target Neighborhood Hits	328	Shared Neighborhood Hits	87
SwissProt Accessions	Q9CXC9, Q3TG49, Q8C0F3, Q9JHB1	Gene names	Etv5
Domain Architecture	No domain graphic available
Description	ETS translocation variant 5.

CALX_HUMAN
NC score	0.003425 (rank : 1798)	θ value	8.99809 (rank : 1676)
Query Neighborhood Hits	1762	Target Neighborhood Hits	96	Shared Neighborhood Hits	23
SwissProt Accessions	P27824	Gene names	CANX
Domain Architecture
Description	Calnexin precursor (Major histocompatibility complex class I antigen- binding protein p88) (p90) (IP90).

ATS19_HUMAN
NC score	0.003317 (rank : 1799)	θ value	2.36792 (rank : 1391)
Query Neighborhood Hits	1762	Target Neighborhood Hits	203	Shared Neighborhood Hits	51
SwissProt Accessions	Q8TE59	Gene names	ADAMTS19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

CLCN1_MOUSE
NC score	0.003096 (rank : 1800)	θ value	6.88961 (rank : 1608)
Query Neighborhood Hits	1762	Target Neighborhood Hits	61	Shared Neighborhood Hits	22
SwissProt Accessions	Q64347	Gene names	Clcn1, Clc1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

MGRN1_HUMAN
NC score	0.002959 (rank : 1801)	θ value	0.47712 (rank : 1179)
Query Neighborhood Hits	1762	Target Neighborhood Hits	192	Shared Neighborhood Hits	19
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

MA1C1_HUMAN
NC score	0.002824 (rank : 1802)	θ value	0.62314 (rank : 1205)
Query Neighborhood Hits	1762	Target Neighborhood Hits	21	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NR34, Q9Y545	Gene names	MAN1C1, MAN1A3, MAN1C
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IC) (Alpha-1,2-mannosidase IC) (Mannosidase alpha class 1C member 1) (HMIC).

SSFA2_HUMAN
NC score	0.002794 (rank : 1803)	θ value	8.99809 (rank : 1747)
Query Neighborhood Hits	1762	Target Neighborhood Hits	40	Shared Neighborhood Hits	11
SwissProt Accessions	P28290, Q96E36	Gene names	SSFA2, CS1
Domain Architecture	No domain graphic available
Description	Sperm-specific antigen 2 (Cleavage signal-1 protein) (CS-1).

NOTC2_MOUSE
NC score	0.002778 (rank : 1804)	θ value	2.36792 (rank : 1423)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1069	Shared Neighborhood Hits	143
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

DIPA_MOUSE
NC score	0.002764 (rank : 1805)	θ value	8.99809 (rank : 1689)
Query Neighborhood Hits	1762	Target Neighborhood Hits	25	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PDY0	Gene names	Ccdc85b, Dipa
Domain Architecture	No domain graphic available
Description	Delta-interacting protein A homolog (Coiled-coil domain-containing protein 85B).

DIPA_HUMAN
NC score	0.002664 (rank : 1806)	θ value	8.99809 (rank : 1688)
Query Neighborhood Hits	1762	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q15834, Q96HA0	Gene names	CCDC85B, DIPA
Domain Architecture	No domain graphic available
Description	Delta-interacting protein A (Hepatitis delta antigen-interacting protein A) (Coiled-coil domain-containing protein 85B).

UBP43_HUMAN
NC score	0.002597 (rank : 1807)	θ value	0.0431538 (rank : 1050)
Query Neighborhood Hits	1762	Target Neighborhood Hits	144	Shared Neighborhood Hits	32
SwissProt Accessions	Q70EL4, Q8N2C5, Q96DQ6	Gene names	USP43
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.1.2.15) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) (Deubiquitinating enzyme 43).

FXR2_MOUSE
NC score	0.002556 (rank : 1808)	θ value	4.03905 (rank : 1508)
Query Neighborhood Hits	1762	Target Neighborhood Hits	66	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WVR4, Q9WVR5	Gene names	Fxr2, Fxr2h
Domain Architecture
Description	Fragile X mental retardation syndrome-related protein 2.

INOC1_HUMAN
NC score	0.002417 (rank : 1809)	θ value	1.38821 (rank : 1317)
Query Neighborhood Hits	1762	Target Neighborhood Hits	181	Shared Neighborhood Hits	25
SwissProt Accessions	Q9ULG1, Q9NTG6	Gene names	INOC1, KIAA1259
Domain Architecture	No domain graphic available
Description	Putative DNA helicase INO80 complex homolog 1 (EC 3.6.1.-) (hINO80).

SEM6B_MOUSE
NC score	0.002344 (rank : 1810)	θ value	0.813845 (rank : 1246)
Query Neighborhood Hits	1762	Target Neighborhood Hits	200	Shared Neighborhood Hits	48
SwissProt Accessions	O54951	Gene names	Sema6b, Seman
Domain Architecture
Description	Semaphorin-6B precursor (Semaphorin VIB) (Sema VIB) (Semaphorin N) (Sema N).

FOXN1_HUMAN
NC score	0.002300 (rank : 1811)	θ value	0.62314 (rank : 1197)
Query Neighborhood Hits	1762	Target Neighborhood Hits	377	Shared Neighborhood Hits	113
SwissProt Accessions	O15353, O15352	Gene names	FOXN1, WHN
Domain Architecture
Description	Forkhead box protein N1 (Transcription factor winged-helix nude).

AKIP_HUMAN
NC score	0.002256 (rank : 1812)	θ value	8.99809 (rank : 1668)
Query Neighborhood Hits	1762	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NWT8, Q5TA36, Q8TBD3	Gene names	AURKAIP1, AIP, AKIP
Domain Architecture	No domain graphic available
Description	Aurora kinase A-interacting protein (AURKA-interacting protein).

SEM6B_HUMAN
NC score	0.002169 (rank : 1813)	θ value	0.47712 (rank : 1186)
Query Neighborhood Hits	1762	Target Neighborhood Hits	187	Shared Neighborhood Hits	53
SwissProt Accessions	Q9H3T3, Q9NRK9	Gene names	SEMA6B, SEMAZ
Domain Architecture
Description	Semaphorin-6B precursor (Semaphorin Z) (Sema Z).

ZDHC8_HUMAN
NC score	0.002151 (rank : 1814)	θ value	6.88961 (rank : 1662)
Query Neighborhood Hits	1762	Target Neighborhood Hits	234	Shared Neighborhood Hits	71
SwissProt Accessions	Q9ULC8, Q6ICL1, Q6ZNF5, Q7Z6L9	Gene names	ZDHHC8, KIAA1292, ZDHHCL1, ZNF378
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC8 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378).

PAR10_HUMAN
NC score	0.002100 (rank : 1815)	θ value	8.99809 (rank : 1723)
Query Neighborhood Hits	1762	Target Neighborhood Hits	142	Shared Neighborhood Hits	32
SwissProt Accessions	Q53GL7, Q8N2I0, Q8WV05, Q96CH7	Gene names	PARP10
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 10 (EC 2.4.2.30) (PARP-10).

FRAT1_MOUSE
NC score	0.002038 (rank : 1816)	θ value	5.27518 (rank : 1562)
Query Neighborhood Hits	1762	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	P70339	Gene names	Frat1
Domain Architecture
Description	Proto-oncogene FRAT1 (Frequently rearranged in advanced T-cell lymphomas) (Frat-1).

PCBP4_HUMAN
NC score	0.001924 (rank : 1817)	θ value	3.0926 (rank : 1475)
Query Neighborhood Hits	1762	Target Neighborhood Hits	49	Shared Neighborhood Hits	12
SwissProt Accessions	P57723, Q96AH7	Gene names	PCBP4
Domain Architecture
Description	Poly(rC)-binding protein 4 (Alpha-CP4).

WFDC1_MOUSE
NC score	0.001853 (rank : 1818)	θ value	6.88961 (rank : 1660)
Query Neighborhood Hits	1762	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ESH5, Q8R110	Gene names	Wfdc1, Ps20
Domain Architecture	No domain graphic available
Description	WAP four-disulfide core domain protein 1 precursor (Prostate stromal protein ps20) (ps20 growth inhibitor).

ZDHC8_MOUSE
NC score	0.001828 (rank : 1819)	θ value	0.813845 (rank : 1252)
Query Neighborhood Hits	1762	Target Neighborhood Hits	243	Shared Neighborhood Hits	69
SwissProt Accessions	Q5Y5T5, Q7TNF7	Gene names	Zdhhc8
Domain Architecture	No domain graphic available
Description	Probable palmitoyltransferase ZDHHC8 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 8) (DHHC-8).

SL9A1_MOUSE
NC score	0.001791 (rank : 1820)	θ value	5.27518 (rank : 1588)
Query Neighborhood Hits	1762	Target Neighborhood Hits	32	Shared Neighborhood Hits	6
SwissProt Accessions	Q61165	Gene names	Slc9a1, Nhe1
Domain Architecture
Description	Sodium/hydrogen exchanger 1 (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1).

OXRP_HUMAN
NC score	0.001754 (rank : 1821)	θ value	1.81305 (rank : 1368)
Query Neighborhood Hits	1762	Target Neighborhood Hits	544	Shared Neighborhood Hits	106
SwissProt Accessions	Q9Y4L1	Gene names	HYOU1, ORP150
Domain Architecture
Description	150 kDa oxygen-regulated protein precursor (Orp150) (Hypoxia up- regulated 1).

DDX51_HUMAN
NC score	0.001667 (rank : 1822)	θ value	5.27518 (rank : 1555)
Query Neighborhood Hits	1762	Target Neighborhood Hits	332	Shared Neighborhood Hits	84
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

MTG8R_HUMAN
NC score	0.001477 (rank : 1823)	θ value	6.88961 (rank : 1634)
Query Neighborhood Hits	1762	Target Neighborhood Hits	125	Shared Neighborhood Hits	31
SwissProt Accessions	O43439, Q5TGE4, Q5TGE7, Q8IWF3, Q96B06, Q96L00, Q9H436, Q9UJP8, Q9UJP9, Q9UP24	Gene names	CBFA2T2, EHT, MTGR1
Domain Architecture
Description	Protein CBFA2T2 (MTG8-like protein) (MTG8-related protein 1) (Myeloid translocation-related protein 1) (ETO homologous on chromosome 20) (p85).

LPIN3_MOUSE
NC score	0.001416 (rank : 1824)	θ value	4.03905 (rank : 1515)
Query Neighborhood Hits	1762	Target Neighborhood Hits	52	Shared Neighborhood Hits	12
SwissProt Accessions	Q99PI4, Q3TQ75, Q8C7R9	Gene names	Lpin3
Domain Architecture
Description	Lipin-3.

RNF6_HUMAN
NC score	0.001365 (rank : 1825)	θ value	0.62314 (rank : 1209)
Query Neighborhood Hits	1762	Target Neighborhood Hits	157	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y252, Q9UF41	Gene names	RNF6
Domain Architecture
Description	RING finger protein 6 (RING-H2 protein).

DEN2C_MOUSE
NC score	0.001342 (rank : 1826)	θ value	0.813845 (rank : 1222)
Query Neighborhood Hits	1762	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	Q6P9P8, Q3T9X2, Q3UV30, Q80V46	Gene names	Dennd2c
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2C.

FBLN2_MOUSE
NC score	0.001333 (rank : 1827)	θ value	0.365318 (rank : 1155)
Query Neighborhood Hits	1762	Target Neighborhood Hits	505	Shared Neighborhood Hits	95
SwissProt Accessions	P37889, Q9WUI2	Gene names	Fbln2
Domain Architecture
Description	Fibulin-2 precursor.

ELF4_HUMAN
NC score	0.001252 (rank : 1828)	θ value	6.88961 (rank : 1616)
Query Neighborhood Hits	1762	Target Neighborhood Hits	87	Shared Neighborhood Hits	22
SwissProt Accessions	Q99607, O60435	Gene names	ELF4, ELFR, MEF
Domain Architecture	No domain graphic available
Description	ETS-related transcription factor Elf-4 (E74-like factor 4) (Myeloid Elf-1-like factor).

ETV5_HUMAN
NC score	0.001247 (rank : 1829)	θ value	8.99809 (rank : 1694)
Query Neighborhood Hits	1762	Target Neighborhood Hits	181	Shared Neighborhood Hits	57
SwissProt Accessions	P41161	Gene names	ETV5, ERM
Domain Architecture
Description	ETS translocation variant 5 (Ets-related protein ERM).

INOC1_MOUSE
NC score	0.001152 (rank : 1830)	θ value	2.36792 (rank : 1416)
Query Neighborhood Hits	1762	Target Neighborhood Hits	178	Shared Neighborhood Hits	25
SwissProt Accessions	Q6ZPV2, Q6P7V0, Q6PCP1, Q8C9T7	Gene names	Inoc1, Kiaa1259
Domain Architecture	No domain graphic available
Description	Putative DNA helicase INO80 complex homolog 1 (EC 3.6.1.-).

EYA4_MOUSE
NC score	0.001038 (rank : 1831)	θ value	5.27518 (rank : 1561)
Query Neighborhood Hits	1762	Target Neighborhood Hits	74	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z191	Gene names	Eya4
Domain Architecture
Description	Eyes absent homolog 4 (EC 3.1.3.48).

SEM6D_MOUSE
NC score	0.000969 (rank : 1832)	θ value	1.06291 (rank : 1286)
Query Neighborhood Hits	1762	Target Neighborhood Hits	161	Shared Neighborhood Hits	36
SwissProt Accessions	Q76KF0, Q76KF1, Q76KF2, Q76KF3, Q76KF4, Q80TD0	Gene names	Sema6d, Kiaa1479
Domain Architecture	No domain graphic available
Description	Semaphorin-6D precursor.

BBS10_MOUSE
NC score	0.000955 (rank : 1833)	θ value	5.27518 (rank : 1546)
Query Neighborhood Hits	1762	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	Q9DBI2	Gene names	Bbs10
Domain Architecture	No domain graphic available
Description	Bardet-Biedl syndrome 10 protein homolog.

TTLL4_HUMAN
NC score	0.000939 (rank : 1834)	θ value	2.36792 (rank : 1441)
Query Neighborhood Hits	1762	Target Neighborhood Hits	79	Shared Neighborhood Hits	19
SwissProt Accessions	Q14679, Q8WW29	Gene names	TTLL4, KIAA0173
Domain Architecture
Description	Tubulin--tyrosine ligase-like protein 4.

RGL2_MOUSE
NC score	0.000935 (rank : 1835)	θ value	8.99809 (rank : 1738)
Query Neighborhood Hits	1762	Target Neighborhood Hits	51	Shared Neighborhood Hits	13
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

NOTC4_HUMAN
NC score	0.000788 (rank : 1836)	θ value	4.03905 (rank : 1518)
Query Neighborhood Hits	1762	Target Neighborhood Hits	905	Shared Neighborhood Hits	85
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

PYR1_HUMAN
NC score	0.000742 (rank : 1837)	θ value	8.99809 (rank : 1737)
Query Neighborhood Hits	1762	Target Neighborhood Hits	119	Shared Neighborhood Hits	27
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].

PKP4_HUMAN
NC score	0.000513 (rank : 1838)	θ value	5.27518 (rank : 1579)
Query Neighborhood Hits	1762	Target Neighborhood Hits	107	Shared Neighborhood Hits	28
SwissProt Accessions	Q99569	Gene names	PKP4
Domain Architecture
Description	Plakophilin-4 (p0071).

KCNQ4_HUMAN
NC score	0.000438 (rank : 1839)	θ value	1.38821 (rank : 1320)
Query Neighborhood Hits	1762	Target Neighborhood Hits	136	Shared Neighborhood Hits	23
SwissProt Accessions	P56696, O96025	Gene names	KCNQ4
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4).

SEM6D_HUMAN
NC score	0.000419 (rank : 1840)	θ value	1.81305 (rank : 1377)
Query Neighborhood Hits	1762	Target Neighborhood Hits	169	Shared Neighborhood Hits	38
SwissProt Accessions	Q8NFY4, Q8NFY3, Q8NFY5, Q8NFY6, Q8NFY7, Q9P249	Gene names	SEMA6D, KIAA1479
Domain Architecture	No domain graphic available
Description	Semaphorin-6D precursor.

EMIL2_HUMAN
NC score	0.000408 (rank : 1841)	θ value	8.99809 (rank : 1690)
Query Neighborhood Hits	1762	Target Neighborhood Hits	573	Shared Neighborhood Hits	96
SwissProt Accessions	Q9BXX0, Q8NBH3, Q96JQ4	Gene names	EMILIN2
Domain Architecture
Description	EMILIN-2 precursor (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2) (Protein FOAP-10).

SMAL1_HUMAN
NC score	0.000198 (rank : 1842)	θ value	6.88961 (rank : 1651)
Query Neighborhood Hits	1762	Target Neighborhood Hits	174	Shared Neighborhood Hits	49
SwissProt Accessions	Q9NZC9, Q96AY1, Q9NXQ5, Q9UFH3, Q9UI93	Gene names	SMARCAL1, HARP
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (hHARP).

TDRD7_MOUSE
NC score	0.000063 (rank : 1843)	θ value	8.99809 (rank : 1753)
Query Neighborhood Hits	1762	Target Neighborhood Hits	39	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K1H1, Q8R181	Gene names	Tdrd7, Pctaire2bp
Domain Architecture
Description	Tudor domain-containing protein 7 (Tudor repeat associator with PCTAIRE 2) (Trap).

PCBP4_MOUSE
NC score	-0.000037 (rank : 1844)	θ value	6.88961 (rank : 1637)
Query Neighborhood Hits	1762	Target Neighborhood Hits	46	Shared Neighborhood Hits	10
SwissProt Accessions	P57724, Q91VR3	Gene names	Pcbp4
Domain Architecture
Description	Poly(rC)-binding protein 4 (Alpha-CP4).

HTF4_MOUSE
NC score	-0.000149 (rank : 1845)	θ value	3.0926 (rank : 1464)
Query Neighborhood Hits	1762	Target Neighborhood Hits	153	Shared Neighborhood Hits	23
SwissProt Accessions	Q61286	Gene names	Tcf12, Alf1, Meb
Domain Architecture
Description	Transcription factor 12 (Transcription factor HTF-4) (E-box-binding protein) (DNA-binding protein HTF4) (Class A helix-loop-helix transcription factor ME1).

ADA12_MOUSE
NC score	-0.000250 (rank : 1846)	θ value	1.06291 (rank : 1255)
Query Neighborhood Hits	1762	Target Neighborhood Hits	474	Shared Neighborhood Hits	124
SwissProt Accessions	Q61824	Gene names	Adam12, Mltna
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

SEM3B_HUMAN
NC score	-0.000261 (rank : 1847)	θ value	2.36792 (rank : 1436)
Query Neighborhood Hits	1762	Target Neighborhood Hits	76	Shared Neighborhood Hits	18
SwissProt Accessions	Q13214, Q8TB71, Q8TDV7, Q93018, Q96GX0	Gene names	SEMA3B, SEMA5
Domain Architecture
Description	Semaphorin-3B precursor (Semaphorin V) (Sema V) (Sema A(V)).

BHLH8_HUMAN
NC score	-0.000327 (rank : 1848)	θ value	0.279714 (rank : 1138)
Query Neighborhood Hits	1762	Target Neighborhood Hits	123	Shared Neighborhood Hits	15
SwissProt Accessions	Q7RTS1	Gene names	BHLHB8, MIST1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

CAN12_HUMAN
NC score	-0.000756 (rank : 1849)	θ value	1.81305 (rank : 1355)
Query Neighborhood Hits	1762	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZSI9	Gene names	CAPN12
Domain Architecture	No domain graphic available
Description	Calpain-12 (EC 3.4.22.-).

NMDE4_HUMAN
NC score	-0.000764 (rank : 1850)	θ value	5.27518 (rank : 1575)
Query Neighborhood Hits	1762	Target Neighborhood Hits	133	Shared Neighborhood Hits	46
SwissProt Accessions	O15399	Gene names	GRIN2D
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 4 precursor (N-methyl D- aspartate receptor subtype 2D) (NR2D) (NMDAR2D) (EB11).

INADL_HUMAN
NC score	-0.000765 (rank : 1851)	θ value	8.99809 (rank : 1707)
Query Neighborhood Hits	1762	Target Neighborhood Hits	260	Shared Neighborhood Hits	36
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

GP152_HUMAN
NC score	-0.000835 (rank : 1852)	θ value	8.99809 (rank : 1703)
Query Neighborhood Hits	1762	Target Neighborhood Hits	636	Shared Neighborhood Hits	137
SwissProt Accessions	Q8TDT2, Q86SM0	Gene names	GPR152, PGR5
Domain Architecture
Description	Probable G-protein coupled receptor 152 (G-protein coupled receptor PGR5).

FOXD2_MOUSE
NC score	-0.000891 (rank : 1853)	θ value	4.03905 (rank : 1507)
Query Neighborhood Hits	1762	Target Neighborhood Hits	130	Shared Neighborhood Hits	30
SwissProt Accessions	O35392	Gene names	Foxd2, Mf2
Domain Architecture
Description	Forkhead box protein D2 (Mesoderm/mesenchyme forkhead 2) (MF-2).

EPIPL_HUMAN
NC score	-0.000971 (rank : 1854)	θ value	8.99809 (rank : 1693)
Query Neighborhood Hits	1762	Target Neighborhood Hits	73	Shared Neighborhood Hits	10
SwissProt Accessions	P58107, Q76E58	Gene names	EPPK1, EPIPL
Domain Architecture
Description	Epiplakin (450 kDa epidermal antigen).

ETV1_HUMAN
NC score	-0.001135 (rank : 1855)	θ value	5.27518 (rank : 1560)
Query Neighborhood Hits	1762	Target Neighborhood Hits	107	Shared Neighborhood Hits	25
SwissProt Accessions	P50549, O75849, Q9UQ71, Q9Y636	Gene names	ETV1, ER81
Domain Architecture
Description	ETS translocation variant 1 (ER81 protein).

PCGF2_HUMAN
NC score	-0.001148 (rank : 1856)	θ value	8.99809 (rank : 1724)
Query Neighborhood Hits	1762	Target Neighborhood Hits	222	Shared Neighborhood Hits	37
SwissProt Accessions	P35227	Gene names	PCGF2, MEL18, RNF110, ZNF144
Domain Architecture
Description	Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144).

FOXK1_MOUSE
NC score	-0.001197 (rank : 1857)	θ value	1.38821 (rank : 1310)
Query Neighborhood Hits	1762	Target Neighborhood Hits	215	Shared Neighborhood Hits	59
SwissProt Accessions	P42128, O35939	Gene names	Foxk1, Mnf
Domain Architecture
Description	Forkhead box protein K1 (Myocyte nuclear factor) (MNF).

RNF12_MOUSE
NC score	-0.001214 (rank : 1858)	θ value	4.03905 (rank : 1525)
Query Neighborhood Hits	1762	Target Neighborhood Hits	159	Shared Neighborhood Hits	15
SwissProt Accessions	Q9WTV7	Gene names	Rnf12, Rlim
Domain Architecture
Description	RING finger protein 12 (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM).

S12A5_HUMAN
NC score	-0.001255 (rank : 1859)	θ value	8.99809 (rank : 1741)
Query Neighborhood Hits	1762	Target Neighborhood Hits	68	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H2X9, Q5VZ41, Q9H4Z0, Q9ULP4	Gene names	SLC12A5, KCC2, KIAA1176
Domain Architecture
Description	Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (Erythroid K-Cl cotransporter 2) (Neuronal K-Cl cotransporter) (hKCC2).

KCNC3_HUMAN
NC score	-0.001262 (rank : 1860)	θ value	3.0926 (rank : 1471)
Query Neighborhood Hits	1762	Target Neighborhood Hits	256	Shared Neighborhood Hits	73
SwissProt Accessions	Q14003	Gene names	KCNC3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

C2TA_MOUSE
NC score	-0.001306 (rank : 1861)	θ value	4.03905 (rank : 1495)
Query Neighborhood Hits	1762	Target Neighborhood Hits	131	Shared Neighborhood Hits	21
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

MBD2_HUMAN
NC score	-0.001371 (rank : 1862)	θ value	8.99809 (rank : 1713)
Query Neighborhood Hits	1762	Target Neighborhood Hits	46	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UBB5, O95242, Q9UIS8	Gene names	MBD2
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 2 (Methyl-CpG-binding protein MBD2) (Demethylase) (DMTase).

CAN12_MOUSE
NC score	-0.001378 (rank : 1863)	θ value	2.36792 (rank : 1396)
Query Neighborhood Hits	1762	Target Neighborhood Hits	56	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ER56, Q9ER53, Q9ER54, Q9ER55	Gene names	Capn12
Domain Architecture
Description	Calpain-12 (EC 3.4.22.-).

S27A4_MOUSE
NC score	-0.001499 (rank : 1864)	θ value	2.36792 (rank : 1434)
Query Neighborhood Hits	1762	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q91VE0, O88562	Gene names	Slc27a4, Acsvl4, Fatp4
Domain Architecture	No domain graphic available
Description	Long-chain fatty acid transport protein 4 (EC 6.2.1.-) (Fatty acid transport protein 4) (FATP-4) (Solute carrier family 27 member 4).

KCNQ1_MOUSE
NC score	-0.001803 (rank : 1865)	θ value	8.99809 (rank : 1710)
Query Neighborhood Hits	1762	Target Neighborhood Hits	175	Shared Neighborhood Hits	39
SwissProt Accessions	P97414, O88702, Q7TNZ1, Q7TPL7, Q80VR7	Gene names	Kcnq1, Kcna9, Kvlqt1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

RFFL_HUMAN
NC score	-0.001918 (rank : 1866)	θ value	2.36792 (rank : 1432)
Query Neighborhood Hits	1762	Target Neighborhood Hits	175	Shared Neighborhood Hits	13
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

MYCL1_HUMAN
NC score	-0.002087 (rank : 1867)	θ value	8.99809 (rank : 1719)
Query Neighborhood Hits	1762	Target Neighborhood Hits	146	Shared Neighborhood Hits	31
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

OLR1_MOUSE
NC score	-0.002142 (rank : 1868)	θ value	8.99809 (rank : 1722)
Query Neighborhood Hits	1762	Target Neighborhood Hits	596	Shared Neighborhood Hits	42
SwissProt Accessions	Q9EQ09	Gene names	Olr1, Lox1
Domain Architecture	No domain graphic available
Description	Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) (Lectin-type oxidized LDL receptor 1) (Lectin-like oxidized LDL receptor 1) (Lectin-like oxLDL receptor 1) (LOX-1) [Contains: Oxidized low-density lipoprotein receptor 1, soluble form].

LEG9_MOUSE
NC score	-0.002676 (rank : 1869)	θ value	8.99809 (rank : 1711)
Query Neighborhood Hits	1762	Target Neighborhood Hits	27	Shared Neighborhood Hits	5
SwissProt Accessions	O08573, O08572	Gene names	Lgals9
Domain Architecture
Description	Galectin-9.

KIF17_MOUSE
NC score	-0.002709 (rank : 1870)	θ value	2.36792 (rank : 1419)
Query Neighborhood Hits	1762	Target Neighborhood Hits	452	Shared Neighborhood Hits	51
SwissProt Accessions	Q99PW8	Gene names	Kif17
Domain Architecture
Description	Kinesin-like protein KIF17 (MmKIF17).

CO6A3_HUMAN
NC score	-0.002785 (rank : 1871)	θ value	5.27518 (rank : 1551)
Query Neighborhood Hits	1762	Target Neighborhood Hits	317	Shared Neighborhood Hits	79
SwissProt Accessions	P12111, Q16501	Gene names	COL6A3
Domain Architecture
Description	Collagen alpha-3(VI) chain precursor.

LTBP3_MOUSE
NC score	-0.002843 (rank : 1872)	θ value	8.99809 (rank : 1712)
Query Neighborhood Hits	1762	Target Neighborhood Hits	475	Shared Neighborhood Hits	61
SwissProt Accessions	Q61810, Q8BNQ6	Gene names	Ltbp3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

FOXP4_MOUSE
NC score	-0.002906 (rank : 1873)	θ value	2.36792 (rank : 1407)
Query Neighborhood Hits	1762	Target Neighborhood Hits	211	Shared Neighborhood Hits	37
SwissProt Accessions	Q9DBY0, Q80V92, Q8CG10, Q8CIS1	Gene names	Foxp4
Domain Architecture	No domain graphic available
Description	Forkhead box protein P4 (Fork head-related protein like A) (mFKHLA).

FOXP4_HUMAN
NC score	-0.003062 (rank : 1874)	θ value	3.0926 (rank : 1460)
Query Neighborhood Hits	1762	Target Neighborhood Hits	246	Shared Neighborhood Hits	53
SwissProt Accessions	Q8IVH2, Q96E19	Gene names	FOXP4, FKHLA
Domain Architecture
Description	Forkhead box protein P4 (Fork head-related protein-like A).

HNF3B_MOUSE
NC score	-0.003137 (rank : 1875)	θ value	1.38821 (rank : 1315)
Query Neighborhood Hits	1762	Target Neighborhood Hits	112	Shared Neighborhood Hits	24
SwissProt Accessions	P35583, Q60602	Gene names	Foxa2, Hnf3b, Tcf-3b, Tcf3b
Domain Architecture
Description	Hepatocyte nuclear factor 3-beta (HNF-3B) (Forkhead box protein A2).

DDX46_MOUSE
NC score	-0.003165 (rank : 1876)	θ value	5.27518 (rank : 1554)
Query Neighborhood Hits	1762	Target Neighborhood Hits	358	Shared Neighborhood Hits	49
SwissProt Accessions	Q569Z5, Q6ZQ42, Q8R0R6	Gene names	Ddx46, Kiaa0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46).

NUCL_HUMAN
NC score	-0.003212 (rank : 1877)	θ value	8.99809 (rank : 1720)
Query Neighborhood Hits	1762	Target Neighborhood Hits	415	Shared Neighborhood Hits	53
SwissProt Accessions	P19338, Q53SK1, Q8NB06	Gene names	NCL
Domain Architecture
Description	Nucleolin (Protein C23).

DDX46_HUMAN
NC score	-0.003278 (rank : 1878)	θ value	6.88961 (rank : 1614)
Query Neighborhood Hits	1762	Target Neighborhood Hits	357	Shared Neighborhood Hits	48
SwissProt Accessions	Q7L014, O94894, Q96EI0, Q9Y658	Gene names	DDX46, KIAA0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46) (PRP5 homolog).

UBP6_HUMAN
NC score	-0.003307 (rank : 1879)	θ value	6.88961 (rank : 1657)
Query Neighborhood Hits	1762	Target Neighborhood Hits	188	Shared Neighborhood Hits	33
SwissProt Accessions	P35125, Q15634, Q86WP6, Q8IWT4	Gene names	USP6, TRE2
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.1.2.15) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6) (Deubiquitinating enzyme 6) (Proto-oncogene TRE-2).

UBP8_MOUSE
NC score	-0.003555 (rank : 1880)	θ value	4.03905 (rank : 1533)
Query Neighborhood Hits	1762	Target Neighborhood Hits	362	Shared Neighborhood Hits	48
SwissProt Accessions	Q80U87, Q80YP2, Q8R0D3, Q9EQU1, Q9WVP5	Gene names	Usp8, Kiaa0055, Ubpy
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (mUBPy).

FOXO4_HUMAN
NC score	-0.003583 (rank : 1881)	θ value	8.99809 (rank : 1698)
Query Neighborhood Hits	1762	Target Neighborhood Hits	197	Shared Neighborhood Hits	54
SwissProt Accessions	P98177, O43821, Q13720, Q3KPF1, Q8TDK9	Gene names	MLLT7, AFX, AFX1, FOXO4
Domain Architecture
Description	Fork head domain transcription factor AFX1 (Forkhead box protein O4).

AT11C_HUMAN
NC score	-0.003718 (rank : 1882)	θ value	2.36792 (rank : 1390)
Query Neighborhood Hits	1762	Target Neighborhood Hits	89	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NB49, Q5JT69, Q5JT70, Q5JT71, Q5JT72, Q5JT73, Q6ZND5, Q6ZU50, Q6ZUP7, Q70IJ9, Q70IK0, Q8WX24	Gene names	ATP11C, ATPIG, ATPIQ
Domain Architecture	No domain graphic available
Description	Probable phospholipid-transporting ATPase IG (EC 3.6.3.1) (ATPase class I type 11C) (ATPase IG) (ATPase IQ) (ATPase class VI type 11C).

SSH2_MOUSE
NC score	-0.003754 (rank : 1883)	θ value	8.99809 (rank : 1748)
Query Neighborhood Hits	1762	Target Neighborhood Hits	119	Shared Neighborhood Hits	19
SwissProt Accessions	Q5SW75, Q3TDK8, Q3TYP8, Q3U2K3, Q5F268, Q5SW74, Q69ZC3, Q76I78	Gene names	Ssh2, Kiaa1725, Ssh2l
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-2L) (mSSH-2L).

HNF3B_HUMAN
NC score	-0.004056 (rank : 1884)	θ value	1.06291 (rank : 1266)
Query Neighborhood Hits	1762	Target Neighborhood Hits	106	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y261, Q8WUW4, Q96DF7	Gene names	FOXA2, HNF3B, TCF3B
Domain Architecture
Description	Hepatocyte nuclear factor 3-beta (HNF-3B) (Forkhead box protein A2).

ZHX1_MOUSE
NC score	-0.004108 (rank : 1885)	θ value	5.27518 (rank : 1596)
Query Neighborhood Hits	1762	Target Neighborhood Hits	334	Shared Neighborhood Hits	29
SwissProt Accessions	P70121, Q8BQ68, Q8C6T4, Q8CJG3	Gene names	Zhx1
Domain Architecture
Description	Zinc fingers and homeoboxes protein 1.

ZFY28_HUMAN
NC score	-0.004706 (rank : 1886)	θ value	6.88961 (rank : 1663)
Query Neighborhood Hits	1762	Target Neighborhood Hits	152	Shared Neighborhood Hits	20
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

PCOC1_HUMAN
NC score	-0.004967 (rank : 1887)	θ value	8.99809 (rank : 1725)
Query Neighborhood Hits	1762	Target Neighborhood Hits	146	Shared Neighborhood Hits	30
SwissProt Accessions	Q15113, O14550	Gene names	PCOLCE, PCPE1
Domain Architecture
Description	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein).

TMPSD_MOUSE
NC score	-0.005286 (rank : 1888)	θ value	0.163984 (rank : 1118)
Query Neighborhood Hits	1762	Target Neighborhood Hits	334	Shared Neighborhood Hits	84
SwissProt Accessions	Q5U405, Q8CFE0, Q91VQ8	Gene names	Tmprss13, Msp
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

TMPSD_HUMAN
NC score	-0.005860 (rank : 1889)	θ value	0.125558 (rank : 1103)
Query Neighborhood Hits	1762	Target Neighborhood Hits	333	Shared Neighborhood Hits	68
SwissProt Accessions	Q9BYE2, Q86YM4, Q96JY8, Q9BYE1	Gene names	TMPRSS13, MSP, TMPRSS11
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

ITAE_MOUSE
NC score	-0.006143 (rank : 1890)	θ value	6.88961 (rank : 1624)
Query Neighborhood Hits	1762	Target Neighborhood Hits	73	Shared Neighborhood Hits	5
SwissProt Accessions	Q60677	Gene names	Itgae
Domain Architecture
Description	Integrin alpha-E precursor (Integrin alpha M290) (CD103 antigen) [Contains: Integrin alpha-E light chain; Integrin alpha-E heavy chain].

ABCA7_HUMAN
NC score	-0.006927 (rank : 1891)	θ value	8.99809 (rank : 1667)
Query Neighborhood Hits	1762	Target Neighborhood Hits	144	Shared Neighborhood Hits	18
SwissProt Accessions	Q8IZY2, Q96S58, Q9BZC4, Q9NR73, Q9UKP8	Gene names	ABCA7
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 7 (Macrophage ABC transporter) (Autoantigen SS-N) (ABCA-SSN).

FOG1_HUMAN
NC score	-0.007035 (rank : 1892)	θ value	0.0961366 (rank : 1074)
Query Neighborhood Hits	1762	Target Neighborhood Hits	981	Shared Neighborhood Hits	175
SwissProt Accessions	Q8IX07	Gene names	ZFPM1, FOG1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

ZN414_HUMAN
NC score	-0.007111 (rank : 1893)	θ value	5.27518 (rank : 1597)
Query Neighborhood Hits	1762	Target Neighborhood Hits	548	Shared Neighborhood Hits	63
SwissProt Accessions	Q96IQ9	Gene names	ZNF414
Domain Architecture	No domain graphic available
Description	Zinc finger protein 414.

DDX51_MOUSE
NC score	-0.007553 (rank : 1894)	θ value	6.88961 (rank : 1615)
Query Neighborhood Hits	1762	Target Neighborhood Hits	130	Shared Neighborhood Hits	17
SwissProt Accessions	Q6P9R1, Q3U7M2	Gene names	Ddx51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

PZRN4_HUMAN
NC score	-0.007615 (rank : 1895)	θ value	5.27518 (rank : 1584)
Query Neighborhood Hits	1762	Target Neighborhood Hits	438	Shared Neighborhood Hits	29
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

TITF1_MOUSE
NC score	-0.007875 (rank : 1896)	θ value	0.0330416 (rank : 1037)
Query Neighborhood Hits	1762	Target Neighborhood Hits	335	Shared Neighborhood Hits	15
SwissProt Accessions	P50220	Gene names	Titf1, Nkx-2.1, Nkx2-1, Ttf1
Domain Architecture	No domain graphic available
Description	Thyroid transcription factor 1 (Thyroid nuclear factor 1) (TTF-1) (Homeobox protein Nkx-2.1).

BOLL_HUMAN
NC score	-0.007948 (rank : 1897)	θ value	3.0926 (rank : 1449)
Query Neighborhood Hits	1762	Target Neighborhood Hits	227	Shared Neighborhood Hits	18
SwissProt Accessions	Q8N9W6, Q969U3	Gene names	BOLL, BOULE
Domain Architecture
Description	Protein boule-like.

FOG1_MOUSE
NC score	-0.008083 (rank : 1898)	θ value	3.0926 (rank : 1459)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1237	Shared Neighborhood Hits	247
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

GEMI5_MOUSE
NC score	-0.008989 (rank : 1899)	θ value	4.03905 (rank : 1510)
Query Neighborhood Hits	1762	Target Neighborhood Hits	424	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BX17	Gene names	Gemin5
Domain Architecture
Description	Gem-associated protein 5 (Gemin5).

2DMB_MOUSE
NC score	-0.009047 (rank : 1900)	θ value	4.03905 (rank : 1490)
Query Neighborhood Hits	1762	Target Neighborhood Hits	214	Shared Neighborhood Hits	15
SwissProt Accessions	P35737	Gene names	H2-DMb1, H-2Mb1, Mb
Domain Architecture
Description	Class II histocompatibility antigen, M beta 1 chain precursor (H2-M beta 1 chain).

TITF1_HUMAN
NC score	-0.010039 (rank : 1901)	θ value	0.21417 (rank : 1132)
Query Neighborhood Hits	1762	Target Neighborhood Hits	332	Shared Neighborhood Hits	15
SwissProt Accessions	P43699, O14954, O14955, Q9BRJ8	Gene names	TITF1, NKX2-1, NKX2A, TTF1
Domain Architecture
Description	Thyroid transcription factor 1 (Thyroid nuclear factor 1) (TTF-1) (Homeobox protein Nkx-2.1) (Homeobox protein NK-2 homolog A).

PCDH8_HUMAN
NC score	-0.010598 (rank : 1902)	θ value	1.38821 (rank : 1329)
Query Neighborhood Hits	1762	Target Neighborhood Hits	164	Shared Neighborhood Hits	12
SwissProt Accessions	O95206, Q8IYE9, Q96SF1	Gene names	PCDH8
Domain Architecture
Description	Protocadherin-8 precursor (Arcadlin).

HB2A_MOUSE
NC score	-0.010832 (rank : 1903)	θ value	1.81305 (rank : 1362)
Query Neighborhood Hits	1762	Target Neighborhood Hits	203	Shared Neighborhood Hits	8
SwissProt Accessions	P14483	Gene names	H2-Ab1, H2-iabeta
Domain Architecture
Description	H-2 class II histocompatibility antigen, A beta chain precursor.

DUX4_HUMAN
NC score	-0.011454 (rank : 1904)	θ value	5.27518 (rank : 1558)
Query Neighborhood Hits	1762	Target Neighborhood Hits	403	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UBX2	Gene names	DUX4, DUX10
Domain Architecture	No domain graphic available
Description	Double homeobox protein 4 (Double homeobox protein 10) (Double homeobox protein 4/10).

HXD9_HUMAN
NC score	-0.011604 (rank : 1905)	θ value	0.62314 (rank : 1203)
Query Neighborhood Hits	1762	Target Neighborhood Hits	352	Shared Neighborhood Hits	21
SwissProt Accessions	P28356	Gene names	HOXD9, HOX4C
Domain Architecture
Description	Homeobox protein Hox-D9 (Hox-4C) (Hox-5.2).

ZN687_HUMAN
NC score	-0.011625 (rank : 1906)	θ value	0.163984 (rank : 1119)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1244	Shared Neighborhood Hits	211
SwissProt Accessions	Q8N1G0, Q68DQ8, Q9H937, Q9P2A7	Gene names	ZNF687, KIAA1441
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

CAD23_MOUSE
NC score	-0.012101 (rank : 1907)	θ value	6.88961 (rank : 1605)
Query Neighborhood Hits	1762	Target Neighborhood Hits	208	Shared Neighborhood Hits	15
SwissProt Accessions	Q99PF4, Q99NH1, Q9D4N9	Gene names	Cdh23
Domain Architecture
Description	Cadherin-23 precursor (Otocadherin).

CDC20_HUMAN
NC score	-0.012938 (rank : 1908)	θ value	5.27518 (rank : 1549)
Query Neighborhood Hits	1762	Target Neighborhood Hits	329	Shared Neighborhood Hits	28
SwissProt Accessions	Q12834, Q9BW56, Q9UQI9	Gene names	CDC20
Domain Architecture
Description	Cell division cycle protein 20 homolog (p55CDC).

HXB3_HUMAN
NC score	-0.013234 (rank : 1909)	θ value	2.36792 (rank : 1414)
Query Neighborhood Hits	1762	Target Neighborhood Hits	559	Shared Neighborhood Hits	82
SwissProt Accessions	P14651, O95615, P17484	Gene names	HOXB3, HOX2G
Domain Architecture
Description	Homeobox protein Hox-B3 (Hox-2G) (Hox-2.7).

ZEP1_MOUSE
NC score	-0.013892 (rank : 1910)	θ value	8.99809 (rank : 1761)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1063	Shared Neighborhood Hits	161
SwissProt Accessions	Q03172	Gene names	Hivep1, Cryabp1, Znf40
Domain Architecture
Description	Zinc finger protein 40 (Transcription factor alphaA-CRYBP1) (Alpha A- crystallin-binding protein I) (Alpha A-CRYBP1).

HMX3_MOUSE
NC score	-0.014389 (rank : 1911)	θ value	1.38821 (rank : 1314)
Query Neighborhood Hits	1762	Target Neighborhood Hits	342	Shared Neighborhood Hits	16
SwissProt Accessions	P42581	Gene names	Hmx3, Nkx-5.1, Nkx5-1
Domain Architecture
Description	Homeobox protein HMX3 (Homeobox protein Nkx-5.1).

HXB2_MOUSE
NC score	-0.015848 (rank : 1912)	θ value	8.99809 (rank : 1705)
Query Neighborhood Hits	1762	Target Neighborhood Hits	350	Shared Neighborhood Hits	25
SwissProt Accessions	P0C1T1	Gene names	Hoxb2, Hox-2.8
Domain Architecture	No domain graphic available
Description	Homeobox protein Hox-B2 (Hox-2.8).

MEOX1_MOUSE
NC score	-0.016797 (rank : 1913)	θ value	5.27518 (rank : 1573)
Query Neighborhood Hits	1762	Target Neighborhood Hits	345	Shared Neighborhood Hits	18
SwissProt Accessions	P32442	Gene names	Meox1, Mox-1, Mox1
Domain Architecture
Description	Homeobox protein MOX-1 (Mesenchyme homeobox 1).

ZN516_MOUSE
NC score	-0.019108 (rank : 1914)	θ value	0.813845 (rank : 1254)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1197	Shared Neighborhood Hits	186
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

ZN447_HUMAN
NC score	-0.019488 (rank : 1915)	θ value	5.27518 (rank : 1598)
Query Neighborhood Hits	1762	Target Neighborhood Hits	899	Shared Neighborhood Hits	107
SwissProt Accessions	Q8TBC5, Q9BRK7, Q9H9A0	Gene names	ZNF447
Domain Architecture	No domain graphic available
Description	Zinc finger protein 447.

ZEP1_HUMAN
NC score	-0.019752 (rank : 1916)	θ value	8.99809 (rank : 1760)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1036	Shared Neighborhood Hits	117
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

GPR37_HUMAN
NC score	-0.019841 (rank : 1917)	θ value	2.36792 (rank : 1411)
Query Neighborhood Hits	1762	Target Neighborhood Hits	584	Shared Neighborhood Hits	14
SwissProt Accessions	O15354, O00348, O14768, Q8TD39	Gene names	GPR37
Domain Architecture
Description	Probable G-protein coupled receptor 37 precursor (Endothelin B receptor-like protein 1) (ETBR-LP-1) (Parkin-associated endothelin receptor-like receptor) (PAELR).

ZN219_HUMAN
NC score	-0.020225 (rank : 1918)	θ value	6.88961 (rank : 1664)
Query Neighborhood Hits	1762	Target Neighborhood Hits	876	Shared Neighborhood Hits	128
SwissProt Accessions	Q9P2Y4, Q8IYC1, Q9BW28	Gene names	ZNF219
Domain Architecture	No domain graphic available
Description	Zinc finger protein 219.

KLF17_HUMAN
NC score	-0.020824 (rank : 1919)	θ value	0.365318 (rank : 1157)
Query Neighborhood Hits	1762	Target Neighborhood Hits	882	Shared Neighborhood Hits	117
SwissProt Accessions	Q5JT82, Q86VQ7, Q8N805	Gene names	KLF17, ZNF393
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 17 (Zinc finger protein 393).

ZN217_HUMAN
NC score	-0.021498 (rank : 1920)	θ value	0.62314 (rank : 1218)
Query Neighborhood Hits	1762	Target Neighborhood Hits	905	Shared Neighborhood Hits	109
SwissProt Accessions	O75362	Gene names	ZNF217, ZABC1
Domain Architecture	No domain graphic available
Description	Zinc finger protein 217.

GLIS3_MOUSE
NC score	-0.021857 (rank : 1921)	θ value	1.38821 (rank : 1311)
Query Neighborhood Hits	1762	Target Neighborhood Hits	861	Shared Neighborhood Hits	90
SwissProt Accessions	Q6XP49, Q8BI60	Gene names	Glis3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS3 (GLI-similar 3).

POGZ_HUMAN
NC score	-0.022901 (rank : 1922)	θ value	8.99809 (rank : 1731)
Query Neighborhood Hits	1762	Target Neighborhood Hits	745	Shared Neighborhood Hits	60
SwissProt Accessions	Q7Z3K3, O75049, Q8TDZ7, Q9Y4X7	Gene names	POGZ, KIAA0461
Domain Architecture
Description	Pogo transposable element with ZNF domain.

SUHW1_HUMAN
NC score	-0.023592 (rank : 1923)	θ value	8.99809 (rank : 1750)
Query Neighborhood Hits	1762	Target Neighborhood Hits	648	Shared Neighborhood Hits	32
SwissProt Accessions	P59817	Gene names	SUHW1
Domain Architecture	No domain graphic available
Description	Suppressor of hairy wing homolog 1 (3'OY11.1).

MTR1L_HUMAN
NC score	-0.024010 (rank : 1924)	θ value	1.81305 (rank : 1367)
Query Neighborhood Hits	1762	Target Neighborhood Hits	1180	Shared Neighborhood Hits	112
SwissProt Accessions	Q13585	Gene names	GPR50
Domain Architecture
Description	Melatonin-related receptor (G protein-coupled receptor 50) (H9).

KLF12_HUMAN
NC score	-0.024040 (rank : 1925)	θ value	0.47712 (rank : 1175)
Query Neighborhood Hits	1762	Target Neighborhood Hits	717	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y4X4, Q5VZM7, Q9UHZ0	Gene names	KLF12, AP2REP
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 12 (Transcriptional repressor AP-2rep).

ZSCA1_HUMAN
NC score	-0.024434 (rank : 1926)	θ value	1.06291 (rank : 1294)
Query Neighborhood Hits	1762	Target Neighborhood Hits	724	Shared Neighborhood Hits	43
SwissProt Accessions	Q8NBB4, Q6WLH8, Q86WS8	Gene names	ZSCAN1
Domain Architecture	No domain graphic available
Description	Zinc finger and SCAN domain-containing protein 1.

ADA2C_MOUSE
NC score	-0.024464 (rank : 1927)	θ value	0.279714 (rank : 1135)
Query Neighborhood Hits	1762	Target Neighborhood Hits	792	Shared Neighborhood Hits	12
SwissProt Accessions	Q01337	Gene names	Adra2c
Domain Architecture
Description	Alpha-2C adrenergic receptor (Alpha-2C adrenoceptor) (Alpha-2C adrenoreceptor) (Alpha-2 adrenergic receptor subtype C4).

ADA2C_HUMAN
NC score	-0.024474 (rank : 1928)	θ value	0.163984 (rank : 1104)
Query Neighborhood Hits	1762	Target Neighborhood Hits	784	Shared Neighborhood Hits	10
SwissProt Accessions	P18825, P35369, Q9HB49	Gene names	ADRA2C
Domain Architecture
Description	Alpha-2C adrenergic receptor (Alpha-2C adrenoceptor) (Alpha-2C adrenoreceptor) (Alpha-2 adrenergic receptor subtype C4).

ZN688_HUMAN
NC score	-0.024560 (rank : 1929)	θ value	0.0193708 (rank : 1012)
Query Neighborhood Hits	1762	Target Neighborhood Hits	873	Shared Neighborhood Hits	89
SwissProt Accessions	Q8WV14, O75701, Q8IW91, Q96MN0	Gene names	ZNF688
Domain Architecture	No domain graphic available
Description	Zinc finger protein 688.

KLF12_MOUSE
NC score	-0.024680 (rank : 1930)	θ value	5.27518 (rank : 1569)
Query Neighborhood Hits	1762	Target Neighborhood Hits	721	Shared Neighborhood Hits	44
SwissProt Accessions	O35738	Gene names	Klf12, Ap2rep
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 12 (Transcriptional repressor AP-2rep).

EGR2_MOUSE
NC score	-0.025030 (rank : 1931)	θ value	0.813845 (rank : 1226)
Query Neighborhood Hits	1762	Target Neighborhood Hits	745	Shared Neighborhood Hits	56
SwissProt Accessions	P08152	Gene names	Egr2, Egr-2, Krox-20, Zfp-25
Domain Architecture	No domain graphic available
Description	Early growth response protein 2 (EGR-2) (Krox-20 protein).

BCL6_HUMAN
NC score	-0.025759 (rank : 1932)	θ value	0.0330416 (rank : 1024)
Query Neighborhood Hits	1762	Target Neighborhood Hits	922	Shared Neighborhood Hits	83
SwissProt Accessions	P41182	Gene names	BCL6, BCL5, LAZ3, ZBTB27, ZNF51
Domain Architecture
Description	B-cell lymphoma 6 protein (BCL-6) (Zinc finger protein 51) (LAZ-3 protein) (BCL-5) (Zinc finger and BTB domain-containing protein 27).

TIEG3_MOUSE
NC score	-0.025794 (rank : 1933)	θ value	8.99809 (rank : 1754)
Query Neighborhood Hits	1762	Target Neighborhood Hits	774	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K1S5, Q8BI37	Gene names	Tieg3, Tieg2b
Domain Architecture
Description	Transforming growth factor-beta-inducible early growth response protein 3 (TGFB-inducible early growth response protein 3) (TIEG-3) (TGFB-inducible early growth response protein 2b).

GLI3_MOUSE
NC score	-0.026163 (rank : 1934)	θ value	8.99809 (rank : 1701)
Query Neighborhood Hits	1762	Target Neighborhood Hits	807	Shared Neighborhood Hits	61
SwissProt Accessions	Q61602	Gene names	Gli3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI3.

BCL6_MOUSE
NC score	-0.026189 (rank : 1935)	θ value	1.81305 (rank : 1354)
Query Neighborhood Hits	1762	Target Neighborhood Hits	913	Shared Neighborhood Hits	83
SwissProt Accessions	P41183, Q61065	Gene names	Bcl6, Bcl-6
Domain Architecture
Description	B-cell lymphoma 6 protein homolog.

ZN174_HUMAN
NC score	-0.026310 (rank : 1936)	θ value	1.38821 (rank : 1347)
Query Neighborhood Hits	1762	Target Neighborhood Hits	744	Shared Neighborhood Hits	52
SwissProt Accessions	Q15697, Q9BQ34	Gene names	ZNF174, ZSCAN8
Domain Architecture
Description	Zinc finger protein 174 (AW-1) (Zinc finger and SCAN domain-containing protein 8).

ZNF19_HUMAN
NC score	-0.026744 (rank : 1937)	θ value	8.99809 (rank : 1762)
Query Neighborhood Hits	1762	Target Neighborhood Hits	751	Shared Neighborhood Hits	40
SwissProt Accessions	P17023, Q86Y66	Gene names	ZNF19, KOX12
Domain Architecture
Description	Zinc finger protein 19 (Zinc finger protein KOX12).

ZN509_MOUSE
NC score	-0.026803 (rank : 1938)	θ value	1.06291 (rank : 1293)
Query Neighborhood Hits	1762	Target Neighborhood Hits	990	Shared Neighborhood Hits	95
SwissProt Accessions	Q8BXX2, Q8CID4, Q8K2Z6	Gene names	Znf509, Zfp509
Domain Architecture	No domain graphic available
Description	Zinc finger protein 509.

ZN250_MOUSE
NC score	-0.027493 (rank : 1939)	θ value	4.03905 (rank : 1538)
Query Neighborhood Hits	1762	Target Neighborhood Hits	773	Shared Neighborhood Hits	39
SwissProt Accessions	Q7TNU6, Q8BJ57	Gene names	Znf250, Zfp647, Znf647
Domain Architecture	No domain graphic available
Description	Zinc finger protein 250 (Zinc finger protein 647).

NPFF1_HUMAN
NC score	-0.028500 (rank : 1940)	θ value	5.27518 (rank : 1576)
Query Neighborhood Hits	1762	Target Neighborhood Hits	858	Shared Neighborhood Hits	8
SwissProt Accessions	Q9GZQ6, Q8NGR0, Q96RN3	Gene names	NPFFR1, GPR147, NPFF1
Domain Architecture
Description	Neuropeptide FF receptor 1 (G-protein coupled receptor 147) (RFamide- related peptide receptor OT7T022).

ZBT7A_HUMAN
NC score	-0.028938 (rank : 1941)	θ value	3.0926 (rank : 1489)
Query Neighborhood Hits	1762	Target Neighborhood Hits	823	Shared Neighborhood Hits	40
SwissProt Accessions	O95365, O00456	Gene names	ZBTB7A, FBI1, LRF, ZBTB7
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 7A (Leukemia/lymphoma- related factor) (Factor that binds to inducer of short transcripts protein 1) (Factor binding IST protein 1) (FBI-1) (HIV-1 1st-binding protein 1) (TTF-I-interacting peptide 21) (TIP21).

ZBT7A_MOUSE
NC score	-0.029095 (rank : 1942)	θ value	4.03905 (rank : 1537)
Query Neighborhood Hits	1762	Target Neighborhood Hits	795	Shared Neighborhood Hits	32
SwissProt Accessions	O88939, Q9CRJ0	Gene names	Zbtb7a, Lrf, Zbtb7
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 7A (Leukemia/lymphoma- related factor).