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Network neighborhood for query Sequence : RTN2_MOUSE

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RTN2_MOUSE
SwissProt Accessions	O70622, O70620	Gene names	Rtn2, Nspl1
Domain Architecture
Description	Reticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like protein 1) (NSPLI).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RTN2_MOUSE
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	48	Target Neighborhood Hits	48	Shared Neighborhood Hits	48
SwissProt Accessions	O70622, O70620	Gene names	Rtn2, Nspl1
Domain Architecture
Description	Reticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like protein 1) (NSPLI).

RTN2_HUMAN
θ value	5.1304e-96 (rank : 2)	NC score	0.962858 (rank : 2)
Query Neighborhood Hits	48	Target Neighborhood Hits	59	Shared Neighborhood Hits	14
SwissProt Accessions	O75298, O60509, Q7RTM6, Q7RTN1, Q7RTN2	Gene names	RTN2, NSPL1
Domain Architecture
Description	Reticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like protein 1) (NSPLI).

RTN1_MOUSE
θ value	6.56568e-51 (rank : 3)	NC score	0.871597 (rank : 6)
Query Neighborhood Hits	48	Target Neighborhood Hits	189	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K0T0, Q8K4S4	Gene names	Rtn1, Nsp
Domain Architecture	No domain graphic available
Description	Reticulon-1 (Neuroendocrine-specific protein).

RTN1_HUMAN
θ value	8.57503e-51 (rank : 4)	NC score	0.874983 (rank : 5)
Query Neighborhood Hits	48	Target Neighborhood Hits	173	Shared Neighborhood Hits	13
SwissProt Accessions	Q16799, Q16800, Q16801	Gene names	RTN1, NSP
Domain Architecture
Description	Reticulon-1 (Neuroendocrine-specific protein).

RTN4_MOUSE
θ value	1.97686e-47 (rank : 5)	NC score	0.802466 (rank : 8)
Query Neighborhood Hits	48	Target Neighborhood Hits	341	Shared Neighborhood Hits	14
SwissProt Accessions	Q99P72, Q5DTK9, Q7TNB7, Q80W95, Q8BGK7, Q8BGM9, Q8K290, Q8K3G8, Q9CTE3	Gene names	Rtn4, Kiaa0886, Nogo
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein).

RTN4_HUMAN
θ value	5.7518e-47 (rank : 6)	NC score	0.804428 (rank : 7)
Query Neighborhood Hits	48	Target Neighborhood Hits	357	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NQC3, O94962, Q9BXG5, Q9H212, Q9H3I3, Q9UQ42, Q9Y293, Q9Y2Y7, Q9Y5U6	Gene names	RTN4, KIAA0886, NOGO
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) (Foocen) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5).

RTN3_MOUSE
θ value	2.76489e-41 (rank : 7)	NC score	0.934476 (rank : 3)
Query Neighborhood Hits	48	Target Neighborhood Hits	10	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ES97	Gene names	Rtn3
Domain Architecture
Description	Reticulon-3.

RTN3_HUMAN
θ value	4.71619e-41 (rank : 8)	NC score	0.934093 (rank : 4)
Query Neighborhood Hits	48	Target Neighborhood Hits	10	Shared Neighborhood Hits	8
SwissProt Accessions	O95197, Q496K2, Q7RTM8	Gene names	RTN3, NSPL2
Domain Architecture
Description	Reticulon-3 (Neuroendocrine-specific protein-like 2) (NSP-like protein II) (NSPLII).

TGON2_HUMAN
θ value	0.125558 (rank : 9)	NC score	0.048245 (rank : 14)
Query Neighborhood Hits	48	Target Neighborhood Hits	1037	Shared Neighborhood Hits	23
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

TRI47_MOUSE
θ value	0.125558 (rank : 10)	NC score	0.026907 (rank : 21)
Query Neighborhood Hits	48	Target Neighborhood Hits	295	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C0E3, Q6P249, Q811J7, Q8BVZ8, Q8R1K0, Q8R3Y1	Gene names	Trim47
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47.

LARGE_MOUSE
θ value	0.21417 (rank : 11)	NC score	0.049594 (rank : 11)
Query Neighborhood Hits	48	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z1M7, Q497S9, Q6P7U2, Q80TW0	Gene names	Large, Kiaa0609, Large1
Domain Architecture
Description	Glycosyltransferase-like protein LARGE1 (EC 2.4.-.-) (Acetylglucosaminyltransferase-like 1A).

NUMA1_HUMAN
θ value	0.21417 (rank : 12)	NC score	0.014095 (rank : 33)
Query Neighborhood Hits	48	Target Neighborhood Hits	1523	Shared Neighborhood Hits	13
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

LARGE_HUMAN
θ value	0.279714 (rank : 13)	NC score	0.048882 (rank : 13)
Query Neighborhood Hits	48	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	O95461, O60348, Q9UGD1, Q9UGE7, Q9UGG3, Q9UGZ8, Q9UH22	Gene names	LARGE, KIAA0609, LARGE1
Domain Architecture
Description	Glycosyltransferase-like protein LARGE1 (EC 2.4.-.-) (Acetylglucosaminyltransferase-like 1A).

SMBT2_HUMAN
θ value	0.279714 (rank : 14)	NC score	0.027205 (rank : 20)
Query Neighborhood Hits	48	Target Neighborhood Hits	44	Shared Neighborhood Hits	2
SwissProt Accessions	Q5VUG0, Q9HCF5	Gene names	SFMBT2, KIAA1617
Domain Architecture	No domain graphic available
Description	Scm-like with four MBT domains protein 2.

TAU_HUMAN
θ value	0.47712 (rank : 15)	NC score	0.028700 (rank : 17)
Query Neighborhood Hits	48	Target Neighborhood Hits	448	Shared Neighborhood Hits	10
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

PDXL2_MOUSE
θ value	0.813845 (rank : 16)	NC score	0.036530 (rank : 16)
Query Neighborhood Hits	48	Target Neighborhood Hits	213	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CAE9, Q8CFW3	Gene names	Podxl2
Domain Architecture	No domain graphic available
Description	Podocalyxin-like protein 2 precursor (Endoglycan).

SRCA_MOUSE
θ value	0.813845 (rank : 17)	NC score	0.027500 (rank : 19)
Query Neighborhood Hits	48	Target Neighborhood Hits	212	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TQ48, Q8BS43	Gene names	Srl, Sar
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

RIMB1_HUMAN
θ value	1.06291 (rank : 18)	NC score	0.019312 (rank : 26)
Query Neighborhood Hits	48	Target Neighborhood Hits	1479	Shared Neighborhood Hits	18
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

ARHGC_MOUSE
θ value	1.38821 (rank : 19)	NC score	0.014634 (rank : 32)
Query Neighborhood Hits	48	Target Neighborhood Hits	344	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

GFI1_HUMAN
θ value	1.38821 (rank : 20)	NC score	0.002176 (rank : 46)
Query Neighborhood Hits	48	Target Neighborhood Hits	726	Shared Neighborhood Hits	4
SwissProt Accessions	Q99684, Q8N564	Gene names	GFI1, ZNF163
Domain Architecture	No domain graphic available
Description	Zinc finger protein Gfi-1 (Growth factor independence 1).

LIRB4_HUMAN
θ value	1.38821 (rank : 21)	NC score	0.013719 (rank : 36)
Query Neighborhood Hits	48	Target Neighborhood Hits	111	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NHJ6, O15468, O75021, Q8N1C7, Q8NHL5	Gene names	LILRB4, ILT3, LIR5
Domain Architecture	No domain graphic available
Description	Leukocyte immunoglobulin-like receptor subfamily B member 4 precursor (Leukocyte immunoglobulin-like receptor 5) (LIR-5) (Immunoglobulin- like transcript 3) (ILT-3) (Monocyte inhibitory receptor HM18) (CD85k antigen).

PI51C_HUMAN
θ value	1.38821 (rank : 22)	NC score	0.022851 (rank : 22)
Query Neighborhood Hits	48	Target Neighborhood Hits	109	Shared Neighborhood Hits	7
SwissProt Accessions	O60331, Q7LE07	Gene names	PIP5K1C, KIAA0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).

IWS1_HUMAN
θ value	1.81305 (rank : 23)	NC score	0.055622 (rank : 9)
Query Neighborhood Hits	48	Target Neighborhood Hits	1241	Shared Neighborhood Hits	24
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

ZF106_HUMAN
θ value	1.81305 (rank : 24)	NC score	0.020162 (rank : 25)
Query Neighborhood Hits	48	Target Neighborhood Hits	470	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H2Y7, Q6NSD9, Q6PEK1, Q86T43, Q86T45, Q86T50, Q86T58, Q86TA9, Q96M37, Q9H7B8	Gene names	ZFP106, ZNF474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 homolog (Zfp-106) (Zinc finger protein 474).

I20RA_HUMAN
θ value	2.36792 (rank : 25)	NC score	0.021342 (rank : 24)
Query Neighborhood Hits	48	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UHF4, Q6UWA9, Q96SH8	Gene names	IL20RA, ZCYTOR7
Domain Architecture	No domain graphic available
Description	Interleukin-20 receptor alpha chain precursor (IL-20R-alpha) (IL-20R1) (Cytokine receptor family 2 member 8) (Cytokine receptor class-II member 8) (CRF2-8) (ZcytoR7).

LUZP1_MOUSE
θ value	2.36792 (rank : 26)	NC score	0.013287 (rank : 37)
Query Neighborhood Hits	48	Target Neighborhood Hits	940	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

SRRM2_MOUSE
θ value	2.36792 (rank : 27)	NC score	0.039774 (rank : 15)
Query Neighborhood Hits	48	Target Neighborhood Hits	1470	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

COTE1_HUMAN
θ value	3.0926 (rank : 28)	NC score	0.049216 (rank : 12)
Query Neighborhood Hits	48	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	P81408	Gene names	C1orf2, COTE1
Domain Architecture	No domain graphic available
Description	Protein COTE1.

NEK1_MOUSE
θ value	3.0926 (rank : 29)	NC score	0.001173 (rank : 47)
Query Neighborhood Hits	48	Target Neighborhood Hits	1311	Shared Neighborhood Hits	11
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

SALL1_HUMAN
θ value	3.0926 (rank : 30)	NC score	0.004120 (rank : 43)
Query Neighborhood Hits	48	Target Neighborhood Hits	821	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NSC2, Q99881, Q9NSC3, Q9P1R0	Gene names	SALL1, SAL1
Domain Architecture
Description	Sal-like protein 1 (Zinc finger protein SALL1) (Spalt-like transcription factor 1) (HSal1).

SRBP2_HUMAN
θ value	3.0926 (rank : 31)	NC score	0.018496 (rank : 27)
Query Neighborhood Hits	48	Target Neighborhood Hits	133	Shared Neighborhood Hits	4
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

UBP42_HUMAN
θ value	3.0926 (rank : 32)	NC score	0.015389 (rank : 30)
Query Neighborhood Hits	48	Target Neighborhood Hits	445	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

FCRLA_HUMAN
θ value	4.03905 (rank : 33)	NC score	0.015981 (rank : 29)
Query Neighborhood Hits	48	Target Neighborhood Hits	135	Shared Neighborhood Hits	4
SwissProt Accessions	Q7L513, Q5VXA1, Q5VXA2, Q5VXA3, Q5VXB0, Q8NEW4, Q8WXH3, Q96PC6, Q96PJ0, Q96PJ1, Q96PJ2, Q96PJ4, Q9BR57	Gene names	FCRLA, FCRL, FCRL1, FCRLM1, FCRX, FREB
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

PARC_HUMAN
θ value	4.03905 (rank : 34)	NC score	0.013913 (rank : 35)
Query Neighborhood Hits	48	Target Neighborhood Hits	148	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).

TRIPC_HUMAN
θ value	4.03905 (rank : 35)	NC score	0.015170 (rank : 31)
Query Neighborhood Hits	48	Target Neighborhood Hits	319	Shared Neighborhood Hits	8
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

ERIC1_HUMAN
θ value	5.27518 (rank : 36)	NC score	0.016581 (rank : 28)
Query Neighborhood Hits	48	Target Neighborhood Hits	364	Shared Neighborhood Hits	6
SwissProt Accessions	Q86X53, Q9P063	Gene names	ERICH1
Domain Architecture	No domain graphic available
Description	Glutamate-rich protein 1.

SEZ6L_HUMAN
θ value	5.27518 (rank : 37)	NC score	0.009098 (rank : 39)
Query Neighborhood Hits	48	Target Neighborhood Hits	289	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BYH1, O95917, Q5THY5, Q6IBZ4, Q6UXD4, Q9NUI3, Q9NUI4, Q9NUI5, Q9Y2E1, Q9Y3J6	Gene names	SEZ6L, KIAA0927
Domain Architecture
Description	Seizure 6-like protein precursor.

TCOF_MOUSE
θ value	5.27518 (rank : 38)	NC score	0.027893 (rank : 18)
Query Neighborhood Hits	48	Target Neighborhood Hits	471	Shared Neighborhood Hits	19
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

DMBT1_HUMAN
θ value	6.88961 (rank : 39)	NC score	0.005329 (rank : 42)
Query Neighborhood Hits	48	Target Neighborhood Hits	152	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UGM3, Q59EX0, Q5JR26, Q6MZN4, Q96DU4, Q9UGM2, Q9UJ57, Q9UKJ4, Q9Y211, Q9Y4V9	Gene names	DMBT1, GP340
Domain Architecture	No domain graphic available
Description	Deleted in malignant brain tumors 1 protein precursor (Glycoprotein 340) (Gp-340) (Surfactant pulmonary-associated D-binding protein).

LMO6_HUMAN
θ value	6.88961 (rank : 40)	NC score	0.005365 (rank : 41)
Query Neighborhood Hits	48	Target Neighborhood Hits	337	Shared Neighborhood Hits	2
SwissProt Accessions	O43900, O76007	Gene names	LMO6
Domain Architecture
Description	LIM domain only protein 6 (Triple LIM domain protein 6).

NEST_HUMAN
θ value	6.88961 (rank : 41)	NC score	0.007774 (rank : 40)
Query Neighborhood Hits	48	Target Neighborhood Hits	1305	Shared Neighborhood Hits	16
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

PRRT3_MOUSE
θ value	6.88961 (rank : 42)	NC score	0.013948 (rank : 34)
Query Neighborhood Hits	48	Target Neighborhood Hits	162	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PE13	Gene names	Prrt3
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

ULK1_MOUSE
θ value	6.88961 (rank : 43)	NC score	0.000480 (rank : 48)
Query Neighborhood Hits	48	Target Neighborhood Hits	1214	Shared Neighborhood Hits	9
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

OGFR_HUMAN
θ value	8.99809 (rank : 44)	NC score	0.053717 (rank : 10)
Query Neighborhood Hits	48	Target Neighborhood Hits	1582	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

REST_MOUSE
θ value	8.99809 (rank : 45)	NC score	0.003261 (rank : 45)
Query Neighborhood Hits	48	Target Neighborhood Hits	1506	Shared Neighborhood Hits	10
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

SPEG_HUMAN
θ value	8.99809 (rank : 46)	NC score	0.004049 (rank : 44)
Query Neighborhood Hits	48	Target Neighborhood Hits	1762	Shared Neighborhood Hits	16
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SPN90_MOUSE
θ value	8.99809 (rank : 47)	NC score	0.011362 (rank : 38)
Query Neighborhood Hits	48	Target Neighborhood Hits	157	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRRM2_HUMAN
θ value	8.99809 (rank : 48)	NC score	0.022356 (rank : 23)
Query Neighborhood Hits	48	Target Neighborhood Hits	1296	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

Hits sorted by NC score

RTN2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	48	Target Neighborhood Hits	48	Shared Neighborhood Hits	48
SwissProt Accessions	O70622, O70620	Gene names	Rtn2, Nspl1
Domain Architecture
Description	Reticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like protein 1) (NSPLI).

RTN2_HUMAN
NC score	0.962858 (rank : 2)	θ value	5.1304e-96 (rank : 2)
Query Neighborhood Hits	48	Target Neighborhood Hits	59	Shared Neighborhood Hits	14
SwissProt Accessions	O75298, O60509, Q7RTM6, Q7RTN1, Q7RTN2	Gene names	RTN2, NSPL1
Domain Architecture
Description	Reticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like protein 1) (NSPLI).

RTN3_MOUSE
NC score	0.934476 (rank : 3)	θ value	2.76489e-41 (rank : 7)
Query Neighborhood Hits	48	Target Neighborhood Hits	10	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ES97	Gene names	Rtn3
Domain Architecture
Description	Reticulon-3.

RTN3_HUMAN
NC score	0.934093 (rank : 4)	θ value	4.71619e-41 (rank : 8)
Query Neighborhood Hits	48	Target Neighborhood Hits	10	Shared Neighborhood Hits	8
SwissProt Accessions	O95197, Q496K2, Q7RTM8	Gene names	RTN3, NSPL2
Domain Architecture
Description	Reticulon-3 (Neuroendocrine-specific protein-like 2) (NSP-like protein II) (NSPLII).

RTN1_HUMAN
NC score	0.874983 (rank : 5)	θ value	8.57503e-51 (rank : 4)
Query Neighborhood Hits	48	Target Neighborhood Hits	173	Shared Neighborhood Hits	13
SwissProt Accessions	Q16799, Q16800, Q16801	Gene names	RTN1, NSP
Domain Architecture
Description	Reticulon-1 (Neuroendocrine-specific protein).

RTN1_MOUSE
NC score	0.871597 (rank : 6)	θ value	6.56568e-51 (rank : 3)
Query Neighborhood Hits	48	Target Neighborhood Hits	189	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K0T0, Q8K4S4	Gene names	Rtn1, Nsp
Domain Architecture	No domain graphic available
Description	Reticulon-1 (Neuroendocrine-specific protein).

RTN4_HUMAN
NC score	0.804428 (rank : 7)	θ value	5.7518e-47 (rank : 6)
Query Neighborhood Hits	48	Target Neighborhood Hits	357	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NQC3, O94962, Q9BXG5, Q9H212, Q9H3I3, Q9UQ42, Q9Y293, Q9Y2Y7, Q9Y5U6	Gene names	RTN4, KIAA0886, NOGO
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) (Foocen) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5).

RTN4_MOUSE
NC score	0.802466 (rank : 8)	θ value	1.97686e-47 (rank : 5)
Query Neighborhood Hits	48	Target Neighborhood Hits	341	Shared Neighborhood Hits	14
SwissProt Accessions	Q99P72, Q5DTK9, Q7TNB7, Q80W95, Q8BGK7, Q8BGM9, Q8K290, Q8K3G8, Q9CTE3	Gene names	Rtn4, Kiaa0886, Nogo
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein).

IWS1_HUMAN
NC score	0.055622 (rank : 9)	θ value	1.81305 (rank : 23)
Query Neighborhood Hits	48	Target Neighborhood Hits	1241	Shared Neighborhood Hits	24
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

OGFR_HUMAN
NC score	0.053717 (rank : 10)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	48	Target Neighborhood Hits	1582	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

LARGE_MOUSE
NC score	0.049594 (rank : 11)	θ value	0.21417 (rank : 11)
Query Neighborhood Hits	48	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z1M7, Q497S9, Q6P7U2, Q80TW0	Gene names	Large, Kiaa0609, Large1
Domain Architecture
Description	Glycosyltransferase-like protein LARGE1 (EC 2.4.-.-) (Acetylglucosaminyltransferase-like 1A).

COTE1_HUMAN
NC score	0.049216 (rank : 12)	θ value	3.0926 (rank : 28)
Query Neighborhood Hits	48	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	P81408	Gene names	C1orf2, COTE1
Domain Architecture	No domain graphic available
Description	Protein COTE1.

LARGE_HUMAN
NC score	0.048882 (rank : 13)	θ value	0.279714 (rank : 13)
Query Neighborhood Hits	48	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	O95461, O60348, Q9UGD1, Q9UGE7, Q9UGG3, Q9UGZ8, Q9UH22	Gene names	LARGE, KIAA0609, LARGE1
Domain Architecture
Description	Glycosyltransferase-like protein LARGE1 (EC 2.4.-.-) (Acetylglucosaminyltransferase-like 1A).

TGON2_HUMAN
NC score	0.048245 (rank : 14)	θ value	0.125558 (rank : 9)
Query Neighborhood Hits	48	Target Neighborhood Hits	1037	Shared Neighborhood Hits	23
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

SRRM2_MOUSE
NC score	0.039774 (rank : 15)	θ value	2.36792 (rank : 27)
Query Neighborhood Hits	48	Target Neighborhood Hits	1470	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

PDXL2_MOUSE
NC score	0.036530 (rank : 16)	θ value	0.813845 (rank : 16)
Query Neighborhood Hits	48	Target Neighborhood Hits	213	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CAE9, Q8CFW3	Gene names	Podxl2
Domain Architecture	No domain graphic available
Description	Podocalyxin-like protein 2 precursor (Endoglycan).

TAU_HUMAN
NC score	0.028700 (rank : 17)	θ value	0.47712 (rank : 15)
Query Neighborhood Hits	48	Target Neighborhood Hits	448	Shared Neighborhood Hits	10
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

TCOF_MOUSE
NC score	0.027893 (rank : 18)	θ value	5.27518 (rank : 38)
Query Neighborhood Hits	48	Target Neighborhood Hits	471	Shared Neighborhood Hits	19
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

SRCA_MOUSE
NC score	0.027500 (rank : 19)	θ value	0.813845 (rank : 17)
Query Neighborhood Hits	48	Target Neighborhood Hits	212	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TQ48, Q8BS43	Gene names	Srl, Sar
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

SMBT2_HUMAN
NC score	0.027205 (rank : 20)	θ value	0.279714 (rank : 14)
Query Neighborhood Hits	48	Target Neighborhood Hits	44	Shared Neighborhood Hits	2
SwissProt Accessions	Q5VUG0, Q9HCF5	Gene names	SFMBT2, KIAA1617
Domain Architecture	No domain graphic available
Description	Scm-like with four MBT domains protein 2.

TRI47_MOUSE
NC score	0.026907 (rank : 21)	θ value	0.125558 (rank : 10)
Query Neighborhood Hits	48	Target Neighborhood Hits	295	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C0E3, Q6P249, Q811J7, Q8BVZ8, Q8R1K0, Q8R3Y1	Gene names	Trim47
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47.

PI51C_HUMAN
NC score	0.022851 (rank : 22)	θ value	1.38821 (rank : 22)
Query Neighborhood Hits	48	Target Neighborhood Hits	109	Shared Neighborhood Hits	7
SwissProt Accessions	O60331, Q7LE07	Gene names	PIP5K1C, KIAA0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).

SRRM2_HUMAN
NC score	0.022356 (rank : 23)	θ value	8.99809 (rank : 48)
Query Neighborhood Hits	48	Target Neighborhood Hits	1296	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

I20RA_HUMAN
NC score	0.021342 (rank : 24)	θ value	2.36792 (rank : 25)
Query Neighborhood Hits	48	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UHF4, Q6UWA9, Q96SH8	Gene names	IL20RA, ZCYTOR7
Domain Architecture	No domain graphic available
Description	Interleukin-20 receptor alpha chain precursor (IL-20R-alpha) (IL-20R1) (Cytokine receptor family 2 member 8) (Cytokine receptor class-II member 8) (CRF2-8) (ZcytoR7).

ZF106_HUMAN
NC score	0.020162 (rank : 25)	θ value	1.81305 (rank : 24)
Query Neighborhood Hits	48	Target Neighborhood Hits	470	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H2Y7, Q6NSD9, Q6PEK1, Q86T43, Q86T45, Q86T50, Q86T58, Q86TA9, Q96M37, Q9H7B8	Gene names	ZFP106, ZNF474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 homolog (Zfp-106) (Zinc finger protein 474).

RIMB1_HUMAN
NC score	0.019312 (rank : 26)	θ value	1.06291 (rank : 18)
Query Neighborhood Hits	48	Target Neighborhood Hits	1479	Shared Neighborhood Hits	18
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SRBP2_HUMAN
NC score	0.018496 (rank : 27)	θ value	3.0926 (rank : 31)
Query Neighborhood Hits	48	Target Neighborhood Hits	133	Shared Neighborhood Hits	4
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

ERIC1_HUMAN
NC score	0.016581 (rank : 28)	θ value	5.27518 (rank : 36)
Query Neighborhood Hits	48	Target Neighborhood Hits	364	Shared Neighborhood Hits	6
SwissProt Accessions	Q86X53, Q9P063	Gene names	ERICH1
Domain Architecture	No domain graphic available
Description	Glutamate-rich protein 1.

FCRLA_HUMAN
NC score	0.015981 (rank : 29)	θ value	4.03905 (rank : 33)
Query Neighborhood Hits	48	Target Neighborhood Hits	135	Shared Neighborhood Hits	4
SwissProt Accessions	Q7L513, Q5VXA1, Q5VXA2, Q5VXA3, Q5VXB0, Q8NEW4, Q8WXH3, Q96PC6, Q96PJ0, Q96PJ1, Q96PJ2, Q96PJ4, Q9BR57	Gene names	FCRLA, FCRL, FCRL1, FCRLM1, FCRX, FREB
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

UBP42_HUMAN
NC score	0.015389 (rank : 30)	θ value	3.0926 (rank : 32)
Query Neighborhood Hits	48	Target Neighborhood Hits	445	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

TRIPC_HUMAN
NC score	0.015170 (rank : 31)	θ value	4.03905 (rank : 35)
Query Neighborhood Hits	48	Target Neighborhood Hits	319	Shared Neighborhood Hits	8
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

ARHGC_MOUSE
NC score	0.014634 (rank : 32)	θ value	1.38821 (rank : 19)
Query Neighborhood Hits	48	Target Neighborhood Hits	344	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

NUMA1_HUMAN
NC score	0.014095 (rank : 33)	θ value	0.21417 (rank : 12)
Query Neighborhood Hits	48	Target Neighborhood Hits	1523	Shared Neighborhood Hits	13
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

PRRT3_MOUSE
NC score	0.013948 (rank : 34)	θ value	6.88961 (rank : 42)
Query Neighborhood Hits	48	Target Neighborhood Hits	162	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PE13	Gene names	Prrt3
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

PARC_HUMAN
NC score	0.013913 (rank : 35)	θ value	4.03905 (rank : 34)
Query Neighborhood Hits	48	Target Neighborhood Hits	148	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).

LIRB4_HUMAN
NC score	0.013719 (rank : 36)	θ value	1.38821 (rank : 21)
Query Neighborhood Hits	48	Target Neighborhood Hits	111	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NHJ6, O15468, O75021, Q8N1C7, Q8NHL5	Gene names	LILRB4, ILT3, LIR5
Domain Architecture	No domain graphic available
Description	Leukocyte immunoglobulin-like receptor subfamily B member 4 precursor (Leukocyte immunoglobulin-like receptor 5) (LIR-5) (Immunoglobulin- like transcript 3) (ILT-3) (Monocyte inhibitory receptor HM18) (CD85k antigen).

LUZP1_MOUSE
NC score	0.013287 (rank : 37)	θ value	2.36792 (rank : 26)
Query Neighborhood Hits	48	Target Neighborhood Hits	940	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

SPN90_MOUSE
NC score	0.011362 (rank : 38)	θ value	8.99809 (rank : 47)
Query Neighborhood Hits	48	Target Neighborhood Hits	157	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SEZ6L_HUMAN
NC score	0.009098 (rank : 39)	θ value	5.27518 (rank : 37)
Query Neighborhood Hits	48	Target Neighborhood Hits	289	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BYH1, O95917, Q5THY5, Q6IBZ4, Q6UXD4, Q9NUI3, Q9NUI4, Q9NUI5, Q9Y2E1, Q9Y3J6	Gene names	SEZ6L, KIAA0927
Domain Architecture
Description	Seizure 6-like protein precursor.

NEST_HUMAN
NC score	0.007774 (rank : 40)	θ value	6.88961 (rank : 41)
Query Neighborhood Hits	48	Target Neighborhood Hits	1305	Shared Neighborhood Hits	16
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

LMO6_HUMAN
NC score	0.005365 (rank : 41)	θ value	6.88961 (rank : 40)
Query Neighborhood Hits	48	Target Neighborhood Hits	337	Shared Neighborhood Hits	2
SwissProt Accessions	O43900, O76007	Gene names	LMO6
Domain Architecture
Description	LIM domain only protein 6 (Triple LIM domain protein 6).

DMBT1_HUMAN
NC score	0.005329 (rank : 42)	θ value	6.88961 (rank : 39)
Query Neighborhood Hits	48	Target Neighborhood Hits	152	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UGM3, Q59EX0, Q5JR26, Q6MZN4, Q96DU4, Q9UGM2, Q9UJ57, Q9UKJ4, Q9Y211, Q9Y4V9	Gene names	DMBT1, GP340
Domain Architecture	No domain graphic available
Description	Deleted in malignant brain tumors 1 protein precursor (Glycoprotein 340) (Gp-340) (Surfactant pulmonary-associated D-binding protein).

SALL1_HUMAN
NC score	0.004120 (rank : 43)	θ value	3.0926 (rank : 30)
Query Neighborhood Hits	48	Target Neighborhood Hits	821	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NSC2, Q99881, Q9NSC3, Q9P1R0	Gene names	SALL1, SAL1
Domain Architecture
Description	Sal-like protein 1 (Zinc finger protein SALL1) (Spalt-like transcription factor 1) (HSal1).

SPEG_HUMAN
NC score	0.004049 (rank : 44)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	48	Target Neighborhood Hits	1762	Shared Neighborhood Hits	16
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

REST_MOUSE
NC score	0.003261 (rank : 45)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	48	Target Neighborhood Hits	1506	Shared Neighborhood Hits	10
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

GFI1_HUMAN
NC score	0.002176 (rank : 46)	θ value	1.38821 (rank : 20)
Query Neighborhood Hits	48	Target Neighborhood Hits	726	Shared Neighborhood Hits	4
SwissProt Accessions	Q99684, Q8N564	Gene names	GFI1, ZNF163
Domain Architecture	No domain graphic available
Description	Zinc finger protein Gfi-1 (Growth factor independence 1).

NEK1_MOUSE
NC score	0.001173 (rank : 47)	θ value	3.0926 (rank : 29)
Query Neighborhood Hits	48	Target Neighborhood Hits	1311	Shared Neighborhood Hits	11
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

ULK1_MOUSE
NC score	0.000480 (rank : 48)	θ value	6.88961 (rank : 43)
Query Neighborhood Hits	48	Target Neighborhood Hits	1214	Shared Neighborhood Hits	9
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).