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Network neighborhood for query Sequence : PARC_HUMAN

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PARC_HUMAN
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CUL7_HUMAN
θ value	0 (rank : 1)	NC score	0.794754 (rank : 3)
Query Neighborhood Hits	148	Target Neighborhood Hits	41	Shared Neighborhood Hits	10
SwissProt Accessions	Q14999, Q5T654	Gene names	CUL7, KIAA0076
Domain Architecture
Description	Cullin-7 (CUL-7).

PARC_HUMAN
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	148	Target Neighborhood Hits	148	Shared Neighborhood Hits	148
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).

PARC_MOUSE
θ value	0 (rank : 3)	NC score	0.986191 (rank : 2)
Query Neighborhood Hits	148	Target Neighborhood Hits	114	Shared Neighborhood Hits	64
SwissProt Accessions	Q80TT8, Q8BKL9, Q8CGC0, Q8R363	Gene names	Parc, Kiaa0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein.

ARI2_HUMAN
θ value	2.67181e-44 (rank : 4)	NC score	0.704588 (rank : 4)
Query Neighborhood Hits	148	Target Neighborhood Hits	113	Shared Neighborhood Hits	40
SwissProt Accessions	O95376, Q9HBZ6, Q9UEM9	Gene names	ARIH2, ARI2, TRIAD1
Domain Architecture
Description	Protein ariadne-2 homolog (ARI-2) (Triad1 protein).

ARI2_MOUSE
θ value	4.55743e-44 (rank : 5)	NC score	0.704003 (rank : 5)
Query Neighborhood Hits	148	Target Neighborhood Hits	106	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Z1K6	Gene names	Arih2, Ari2, Triad1, Uip48
Domain Architecture
Description	Protein ariadne-2 homolog (ARI-2) (Triad1 protein) (UbcM4-interacting protein 48).

ARI1_HUMAN
θ value	2.26708e-35 (rank : 6)	NC score	0.688363 (rank : 6)
Query Neighborhood Hits	148	Target Neighborhood Hits	71	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y4X5, O76026, Q9H3T6, Q9UEN0, Q9UP39	Gene names	ARIH1, ARI, UBCH7BP
Domain Architecture
Description	Protein ariadne-1 homolog (ARI-1) (Ubiquitin-conjugating enzyme E2- binding protein 1) (UbcH7-binding protein) (UbcM4-interacting protein) (HHARI) (H7-AP2) (MOP-6).

ARI1_MOUSE
θ value	2.26708e-35 (rank : 7)	NC score	0.688230 (rank : 7)
Query Neighborhood Hits	148	Target Neighborhood Hits	71	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z1K5, Q6PF92	Gene names	Arih1, Ari, Ubch7bp, Uip77
Domain Architecture	No domain graphic available
Description	Protein ariadne-1 homolog (ARI-1) (Ubiquitin-conjugating enzyme E2- binding protein 1) (UbcH7-binding protein) (UbcM4-interacting protein 77).

HECD3_MOUSE
θ value	1.33526e-19 (rank : 8)	NC score	0.356604 (rank : 25)
Query Neighborhood Hits	148	Target Neighborhood Hits	47	Shared Neighborhood Hits	10
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HERC2_HUMAN
θ value	1.74391e-19 (rank : 9)	NC score	0.260986 (rank : 30)
Query Neighborhood Hits	148	Target Neighborhood Hits	163	Shared Neighborhood Hits	10
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HECD3_HUMAN
θ value	5.07402e-19 (rank : 10)	NC score	0.356785 (rank : 24)
Query Neighborhood Hits	148	Target Neighborhood Hits	49	Shared Neighborhood Hits	9
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

RNF14_HUMAN
θ value	4.29542e-18 (rank : 11)	NC score	0.592242 (rank : 9)
Query Neighborhood Hits	148	Target Neighborhood Hits	70	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UBS8, O94793, Q6IBV0	Gene names	RNF14, ARA54
Domain Architecture
Description	RING finger protein 14 (Androgen receptor-associated protein 54) (Triad2 protein) (HFB30).

HERC2_MOUSE
θ value	5.60996e-18 (rank : 12)	NC score	0.254636 (rank : 31)
Query Neighborhood Hits	148	Target Neighborhood Hits	167	Shared Neighborhood Hits	9
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

RNF14_MOUSE
θ value	1.63225e-17 (rank : 13)	NC score	0.593726 (rank : 8)
Query Neighborhood Hits	148	Target Neighborhood Hits	69	Shared Neighborhood Hits	25
SwissProt Accessions	Q9JI90, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89	Gene names	Rnf14, Ara54, Triad2
Domain Architecture
Description	RING finger protein 14 (Androgen receptor-associated protein 54) (Triad2 protein).

IBRD3_HUMAN
θ value	4.02038e-16 (rank : 14)	NC score	0.567469 (rank : 12)
Query Neighborhood Hits	148	Target Neighborhood Hits	70	Shared Neighborhood Hits	29
SwissProt Accessions	Q6ZMZ0, Q6P6A4	Gene names	IBRDC3
Domain Architecture	No domain graphic available
Description	IBR domain-containing protein 3.

RNF19_HUMAN
θ value	8.95645e-16 (rank : 15)	NC score	0.535592 (rank : 16)
Query Neighborhood Hits	148	Target Neighborhood Hits	105	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NV58, Q9H5H9, Q9H8M8, Q9UFG0, Q9UFX6, Q9Y4Y1	Gene names	RNF19
Domain Architecture
Description	RING finger protein 19 (Dorfin) (Double ring-finger protein) (p38 protein).

RNF19_MOUSE
θ value	8.95645e-16 (rank : 16)	NC score	0.537188 (rank : 15)
Query Neighborhood Hits	148	Target Neighborhood Hits	96	Shared Neighborhood Hits	32
SwissProt Accessions	P50636, Q9QUJ5	Gene names	Rnf19, Geg-154, Xybp
Domain Architecture
Description	RING finger protein 19 (XY body protein) (XYbp) (Gametogenesis expressed protein GEG-154) (UBCM4-interacting protein 117) (UIP117).

UB7I4_MOUSE
θ value	2.20605e-14 (rank : 17)	NC score	0.572828 (rank : 10)
Query Neighborhood Hits	148	Target Neighborhood Hits	59	Shared Neighborhood Hits	26
SwissProt Accessions	Q925F3, Q6A0B4	Gene names	Rnf144, Kiaa0161, Ubce7ip4, Uip4
Domain Architecture
Description	Ubiquitin-conjugating enzyme 7-interacting protein 4 (UbcM4- interacting protein 4) (RING finger protein 144).

UB7I4_HUMAN
θ value	6.41864e-14 (rank : 18)	NC score	0.569648 (rank : 11)
Query Neighborhood Hits	148	Target Neighborhood Hits	54	Shared Neighborhood Hits	26
SwissProt Accessions	P50876	Gene names	RNF144, KIAA0161, UBCE7IP4
Domain Architecture
Description	Ubiquitin-conjugating enzyme 7-interacting protein 4 (UbcM4- interacting protein 4) (RING finger protein 144).

IBRD2_MOUSE
θ value	1.33837e-11 (rank : 19)	NC score	0.551799 (rank : 13)
Query Neighborhood Hits	148	Target Neighborhood Hits	46	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BKD6, Q8BG97	Gene names	Ibrdc2
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase IBRDC2 (EC 6.3.2.-) (IBR domain-containing protein 2).

PRKN2_HUMAN
θ value	5.08577e-11 (rank : 20)	NC score	0.499873 (rank : 19)
Query Neighborhood Hits	148	Target Neighborhood Hits	65	Shared Neighborhood Hits	24
SwissProt Accessions	O60260, Q5TFV8, Q6Q2I6, Q8NI41, Q8NI43, Q8NI44, Q8WW07	Gene names	PARK2, PRKN
Domain Architecture	No domain graphic available
Description	Parkin (EC 6.3.2.-) (Ubiquitin E3 ligase PRKN) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2).

PRKN2_MOUSE
θ value	5.08577e-11 (rank : 21)	NC score	0.501651 (rank : 18)
Query Neighborhood Hits	148	Target Neighborhood Hits	69	Shared Neighborhood Hits	24
SwissProt Accessions	Q9WVS6, Q9ES22, Q9ES23	Gene names	Park2, Prkn
Domain Architecture	No domain graphic available
Description	Parkin (EC 6.3.2.-) (Ubiquitin E3 ligase PRKN).

IBRD2_HUMAN
θ value	1.47974e-10 (rank : 22)	NC score	0.539059 (rank : 14)
Query Neighborhood Hits	148	Target Neighborhood Hits	55	Shared Neighborhood Hits	24
SwissProt Accessions	Q7Z419, Q6P4Q0, Q8N3R7, Q9BX38	Gene names	IBRDC2, P53RFP
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase IBRDC2 (EC 6.3.2.-) (IBR domain-containing protein 2) (p53-inducible RING finger protein).

RNF31_MOUSE
θ value	1.38499e-08 (rank : 23)	NC score	0.420591 (rank : 23)
Query Neighborhood Hits	148	Target Neighborhood Hits	113	Shared Neighborhood Hits	25
SwissProt Accessions	Q924T7	Gene names	Rnf31
Domain Architecture
Description	RING finger protein 31.

RNF31_HUMAN
θ value	1.80886e-08 (rank : 24)	NC score	0.423928 (rank : 22)
Query Neighborhood Hits	148	Target Neighborhood Hits	110	Shared Neighborhood Hits	25
SwissProt Accessions	Q96EP0, Q86VI2, Q8TEI0, Q96GB4, Q96NF1, Q9H5F1, Q9NWD2	Gene names	RNF31, ZIBRA
Domain Architecture
Description	RING finger protein 31 (Zinc in-between-RING-finger ubiquitin- associated domain protein).

UB7I3_MOUSE
θ value	2.36244e-08 (rank : 25)	NC score	0.441749 (rank : 20)
Query Neighborhood Hits	148	Target Neighborhood Hits	131	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WUB0	Gene names	Rbck1, Rbck, Ubce7ip3, Uip28
Domain Architecture
Description	RanBP-type and C3HC4-type zinc finger-containing protein 1 (Ubiquitin- conjugating enzyme 7-interacting protein 3) (UbcM4-interacting protein 28).

UB7I3_HUMAN
θ value	1.53129e-07 (rank : 26)	NC score	0.439187 (rank : 21)
Query Neighborhood Hits	148	Target Neighborhood Hits	136	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BYM8, O95623, Q96BS3, Q9BYM9	Gene names	RBCK1, C20orf18, RNF54, UBCE7IP3, XAP4
Domain Architecture
Description	RanBP-type and C3HC4-type zinc finger-containing protein 1 (Ubiquitin- conjugating enzyme 7-interacting protein 3) (Hepatitis B virus X- associated protein 4) (HBV-associated factor 4) (RING finger protein 54).

IBRD1_HUMAN
θ value	2.61198e-07 (rank : 27)	NC score	0.533604 (rank : 17)
Query Neighborhood Hits	148	Target Neighborhood Hits	62	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TC41, Q9BX48	Gene names	IBRDC1
Domain Architecture	No domain graphic available
Description	IBR domain-containing protein 1.

CUL4B_HUMAN
θ value	4.1701e-05 (rank : 28)	NC score	0.120236 (rank : 32)
Query Neighborhood Hits	148	Target Neighborhood Hits	80	Shared Neighborhood Hits	7
SwissProt Accessions	Q13620, Q6PIE4, Q6UP07, Q7Z673, Q9BY37, Q9UEB7, Q9UED7	Gene names	CUL4B, KIAA0695
Domain Architecture
Description	Cullin-4B (CUL-4B).

CUL4A_MOUSE
θ value	0.000602161 (rank : 29)	NC score	0.118158 (rank : 34)
Query Neighborhood Hits	148	Target Neighborhood Hits	31	Shared Neighborhood Hits	7
SwissProt Accessions	Q3TCH7, Q3THM3, Q91Z44	Gene names	Cul4a
Domain Architecture	No domain graphic available
Description	Cullin-4A (CUL-4A).

CUL4A_HUMAN
θ value	0.00175202 (rank : 30)	NC score	0.118721 (rank : 33)
Query Neighborhood Hits	148	Target Neighborhood Hits	40	Shared Neighborhood Hits	7
SwissProt Accessions	Q13619, O75834, Q589T6, Q5TC62, Q6UP08, Q9UP17	Gene names	CUL4A
Domain Architecture
Description	Cullin-4A (CUL-4A).

APC10_HUMAN
θ value	0.00228821 (rank : 31)	NC score	0.274878 (rank : 28)
Query Neighborhood Hits	148	Target Neighborhood Hits	10	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UM13, Q2V500, Q9UG51, Q9Y5R0	Gene names	ANAPC10, APC10
Domain Architecture
Description	Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10).

APC10_MOUSE
θ value	0.00228821 (rank : 32)	NC score	0.272998 (rank : 29)
Query Neighborhood Hits	148	Target Neighborhood Hits	9	Shared Neighborhood Hits	9
SwissProt Accessions	Q8K2H6, Q9CW24	Gene names	Anapc10, Apc10
Domain Architecture
Description	Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10).

CUL3_HUMAN
θ value	0.0252991 (rank : 33)	NC score	0.084673 (rank : 36)
Query Neighborhood Hits	148	Target Neighborhood Hits	42	Shared Neighborhood Hits	8
SwissProt Accessions	Q13618, O75415, Q569L3, Q9UBI8, Q9UET7	Gene names	CUL3, KIAA0617
Domain Architecture
Description	Cullin-3 (CUL-3).

CUL3_MOUSE
θ value	0.0252991 (rank : 34)	NC score	0.084827 (rank : 35)
Query Neighborhood Hits	148	Target Neighborhood Hits	39	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JLV5	Gene names	Cul3
Domain Architecture
Description	Cullin-3 (CUL-3).

PDE9A_MOUSE
θ value	0.0252991 (rank : 35)	NC score	0.040607 (rank : 66)
Query Neighborhood Hits	148	Target Neighborhood Hits	72	Shared Neighborhood Hits	4
SwissProt Accessions	O70628	Gene names	Pde9a, Pde8b
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

UB7I1_HUMAN
θ value	0.0252991 (rank : 36)	NC score	0.309899 (rank : 26)
Query Neighborhood Hits	148	Target Neighborhood Hits	177	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NWF9, Q6Y691, Q75ML7, Q7Z2H7, Q7Z7C1, Q8NHW7, Q9NYT1	Gene names	UBCE7IP1, ZIN
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase TRIAD3 (EC 6.3.2.-) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (Zinc finger protein inhibiting NF-kappa-B) (Triad domain-containing protein 3).

NOL8_MOUSE
θ value	0.0563607 (rank : 37)	NC score	0.041338 (rank : 65)
Query Neighborhood Hits	148	Target Neighborhood Hits	210	Shared Neighborhood Hits	5
SwissProt Accessions	Q3UHX0, Q504M4, Q8CDJ7, Q9CUR0	Gene names	Nol8
Domain Architecture	No domain graphic available
Description	Nucleolar protein 8.

PDE9A_HUMAN
θ value	0.0736092 (rank : 38)	NC score	0.037135 (rank : 68)
Query Neighborhood Hits	148	Target Neighborhood Hits	93	Shared Neighborhood Hits	4
SwissProt Accessions	O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0	Gene names	PDE9A
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

UB7I1_MOUSE
θ value	0.0961366 (rank : 39)	NC score	0.307020 (rank : 27)
Query Neighborhood Hits	148	Target Neighborhood Hits	206	Shared Neighborhood Hits	27
SwissProt Accessions	P58283, Q3U493, Q3UE56, Q3UGM3, Q68FN0, Q6P1H8, Q6PWY5, Q8BN27, Q8C1U3	Gene names	Ubce7ip1, Triad3, Uip83, Zin
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase TRIAD3 (EC 6.3.2.-) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (UbcM4-interacting protein 83) (Triad domain- containing protein 3).

INHA_HUMAN
θ value	0.125558 (rank : 40)	NC score	0.033060 (rank : 73)
Query Neighborhood Hits	148	Target Neighborhood Hits	66	Shared Neighborhood Hits	2
SwissProt Accessions	P05111	Gene names	INHA
Domain Architecture
Description	Inhibin alpha chain precursor.

CNOT4_HUMAN
θ value	0.163984 (rank : 41)	NC score	0.062314 (rank : 42)
Query Neighborhood Hits	148	Target Neighborhood Hits	207	Shared Neighborhood Hits	6
SwissProt Accessions	O95628, O95339, O95627, Q8IYM7, Q8NCL0, Q9NPQ1, Q9NZN6	Gene names	CNOT4, NOT4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

CNOT4_MOUSE
θ value	0.163984 (rank : 42)	NC score	0.059514 (rank : 43)
Query Neighborhood Hits	148	Target Neighborhood Hits	277	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BT14, Q8CCR4, Q9CV74, Q9Z1D0	Gene names	Cnot4, Not4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

FBN3_HUMAN
θ value	0.163984 (rank : 43)	NC score	0.017827 (rank : 89)
Query Neighborhood Hits	148	Target Neighborhood Hits	543	Shared Neighborhood Hits	20
SwissProt Accessions	Q75N90, Q75N91, Q75N92, Q75N93, Q86SJ5, Q96JP8	Gene names	FBN3, KIAA1776
Domain Architecture	No domain graphic available
Description	Fibrillin-3 precursor.

NEST_HUMAN
θ value	0.21417 (rank : 44)	NC score	0.013627 (rank : 102)
Query Neighborhood Hits	148	Target Neighborhood Hits	1305	Shared Neighborhood Hits	20
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

GOLI_HUMAN
θ value	0.365318 (rank : 45)	NC score	0.051723 (rank : 51)
Query Neighborhood Hits	148	Target Neighborhood Hits	137	Shared Neighborhood Hits	15
SwissProt Accessions	Q86XS8, Q641P9, Q6P177, Q7L2U2, Q9P0J9	Gene names	RNF130
Domain Architecture	No domain graphic available
Description	Goliath homolog precursor (RING finger protein 130).

GOLI_MOUSE
θ value	0.365318 (rank : 46)	NC score	0.043094 (rank : 63)
Query Neighborhood Hits	148	Target Neighborhood Hits	134	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VEM1, Q80VL7, Q9QZQ6	Gene names	Rnf130, G1rp
Domain Architecture	No domain graphic available
Description	Goliath homolog precursor (RING finger protein 130) (G1-related zinc finger protein).

PEX10_HUMAN
θ value	0.47712 (rank : 47)	NC score	0.071111 (rank : 40)
Query Neighborhood Hits	148	Target Neighborhood Hits	255	Shared Neighborhood Hits	25
SwissProt Accessions	O60683, Q5T095, Q9BW90	Gene names	PEX10, RNF69
Domain Architecture
Description	Peroxisome assembly protein 10 (Peroxin-10) (Peroxisome biogenesis factor 10) (RING finger protein 69).

NUMA1_HUMAN
θ value	0.62314 (rank : 48)	NC score	0.006540 (rank : 142)
Query Neighborhood Hits	148	Target Neighborhood Hits	1523	Shared Neighborhood Hits	21
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

TRIM9_HUMAN
θ value	0.62314 (rank : 49)	NC score	0.042449 (rank : 64)
Query Neighborhood Hits	148	Target Neighborhood Hits	294	Shared Neighborhood Hits	11
SwissProt Accessions	Q9C026, Q92557, Q96D24, Q96NI4, Q9C025, Q9C027	Gene names	TRIM9, KIAA0282, RNF91
Domain Architecture
Description	Tripartite motif-containing protein 9 (RING finger protein 91).

CD177_HUMAN
θ value	0.813845 (rank : 50)	NC score	0.054984 (rank : 45)
Query Neighborhood Hits	148	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N6Q3, Q711Q2, Q8NCV9, Q96QH1, Q9HDA5	Gene names	CD177, NB1, PRV1
Domain Architecture	No domain graphic available
Description	CD177 antigen precursor (Polycythemia rubra vera protein 1) (PRV-1) (NB1 glycoprotein) (NB1 GP) (Human neutrophil alloantigen 2a) (HNA- 2a).

OST3B_MOUSE
θ value	0.813845 (rank : 51)	NC score	0.012538 (rank : 112)
Query Neighborhood Hits	148	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QZS6	Gene names	Hs3st3b1, 3ost3b1, Hs3st3b
Domain Architecture	No domain graphic available
Description	Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 (EC 2.8.2.30) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1) (Heparan sulfate 3-O-sulfotransferase 3B1) (m3-OST-3B).

TOPRS_HUMAN
θ value	0.813845 (rank : 52)	NC score	0.070819 (rank : 41)
Query Neighborhood Hits	148	Target Neighborhood Hits	286	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NS56, O43273, Q6P987, Q9NS55, Q9UNR9	Gene names	TOPORS, LUN, TP53BPL
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

TOPRS_MOUSE
θ value	0.813845 (rank : 53)	NC score	0.072155 (rank : 39)
Query Neighborhood Hits	148	Target Neighborhood Hits	263	Shared Neighborhood Hits	30
SwissProt Accessions	Q80Z37, Q3U5B5, Q3UPZ1, Q3USN3, Q3UZ55, Q8BXP2, Q8CFF5, Q8CGC8, Q920L3	Gene names	Topors
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

YETS2_HUMAN
θ value	0.813845 (rank : 54)	NC score	0.022971 (rank : 86)
Query Neighborhood Hits	148	Target Neighborhood Hits	212	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ULM3, Q641P6, Q9NW96	Gene names	YEATS2, KIAA1197
Domain Architecture	No domain graphic available
Description	YEATS domain-containing protein 2.

ZEP1_HUMAN
θ value	0.813845 (rank : 55)	NC score	0.013402 (rank : 103)
Query Neighborhood Hits	148	Target Neighborhood Hits	1036	Shared Neighborhood Hits	12
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

CLUA1_HUMAN
θ value	1.06291 (rank : 56)	NC score	0.032627 (rank : 74)
Query Neighborhood Hits	148	Target Neighborhood Hits	236	Shared Neighborhood Hits	5
SwissProt Accessions	Q96AJ1, O75138, Q65ZA3, Q9H8R4, Q9H8T1	Gene names	CLUAP1, KIAA0643
Domain Architecture	No domain graphic available
Description	Clusterin-associated protein 1.

CLUA1_MOUSE
θ value	1.06291 (rank : 57)	NC score	0.032302 (rank : 76)
Query Neighborhood Hits	148	Target Neighborhood Hits	261	Shared Neighborhood Hits	10
SwissProt Accessions	Q8R3P7, Q6P3Y8	Gene names	Cluap1
Domain Architecture	No domain graphic available
Description	Clusterin-associated protein 1.

STX4_HUMAN
θ value	1.06291 (rank : 58)	NC score	0.016402 (rank : 93)
Query Neighborhood Hits	148	Target Neighborhood Hits	266	Shared Neighborhood Hits	7
SwissProt Accessions	Q12846, Q15525	Gene names	STX4, STX4A
Domain Architecture
Description	Syntaxin-4 (NY-REN-31 antigen).

ADA18_MOUSE
θ value	1.38821 (rank : 59)	NC score	0.011975 (rank : 114)
Query Neighborhood Hits	148	Target Neighborhood Hits	227	Shared Neighborhood Hits	15
SwissProt Accessions	Q9R157, Q60621	Gene names	Adam18, Adam27, Dtgn3, Tmdc3
Domain Architecture
Description	ADAM 18 precursor (A disintegrin and metalloproteinase domain 18) (Transmembrane metalloproteinase-like, disintegrin-like, and cysteine- rich protein III) (tMDC III) (ADAM 27).

B3A4_HUMAN
θ value	1.38821 (rank : 60)	NC score	0.010983 (rank : 121)
Query Neighborhood Hits	148	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	Q96Q91, Q96RM5, Q9BXF2, Q9BXN3	Gene names	SLC4A9, AE4, SBC5
Domain Architecture
Description	Anion exchange protein 4 (Anion exchanger 4) (Solute carrier family 4 member 9) (Sodium bicarbonate cotransporter 5).

DNJC3_MOUSE
θ value	1.38821 (rank : 61)	NC score	0.017502 (rank : 90)
Query Neighborhood Hits	148	Target Neighborhood Hits	230	Shared Neighborhood Hits	5
SwissProt Accessions	Q91YW3, Q60873	Gene names	Dnajc3, P58ipk
Domain Architecture	No domain graphic available
Description	DnaJ homolog subfamily C member 3 (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor p58) (Protein kinase inhibitor of 58 kDa).

JIP4_HUMAN
θ value	1.38821 (rank : 62)	NC score	0.013182 (rank : 105)
Query Neighborhood Hits	148	Target Neighborhood Hits	585	Shared Neighborhood Hits	7
SwissProt Accessions	O60271, O60905, Q3KQU8, Q3MKM7, Q86WC7, Q86WC8, Q8IZX7, Q96II0, Q9H811	Gene names	SPAG9, HSS, KIAA0516, MAPK8IP4, SYD1
Domain Architecture	No domain graphic available
Description	C-jun-amino-terminal kinase-interacting protein 4 (JNK-interacting protein 4) (JIP-4) (JNK-associated leucine-zipper protein) (JLP) (Sperm-associated antigen 9) (Mitogen-activated protein kinase 8- interacting protein 4) (Human lung cancer protein 6) (HLC-6) (Proliferation-inducing protein 6) (Sperm-specific protein) (Sperm surface protein) (Protein highly expressed in testis) (PHET) (Sunday driver 1).

PCSK5_HUMAN
θ value	1.38821 (rank : 63)	NC score	0.009853 (rank : 125)
Query Neighborhood Hits	148	Target Neighborhood Hits	291	Shared Neighborhood Hits	10
SwissProt Accessions	Q92824, Q13527	Gene names	PCSK5, PC5, PC6
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (hPC6).

IPO9_HUMAN
θ value	1.81305 (rank : 64)	NC score	0.027979 (rank : 77)
Query Neighborhood Hits	148	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	Q96P70, Q8N1Y1, Q8N3I2, Q8NCG9, Q96SU6, Q9NW01, Q9P0A8, Q9ULM8	Gene names	IPO9, IMP9, KIAA1192, RANBP9
Domain Architecture
Description	Importin-9 (Imp9) (Ran-binding protein 9) (RanbP9).

IPO9_MOUSE
θ value	1.81305 (rank : 65)	NC score	0.027916 (rank : 78)
Query Neighborhood Hits	148	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q91YE6, Q924M3, Q924M4	Gene names	Ipo9, Imp9, Ranbp9
Domain Architecture
Description	Importin-9 (Importin 9a) (Imp9a) (Importin 9b) (Imp9b) (Ran-binding protein 9) (RanBP9).

MICA2_HUMAN
θ value	1.81305 (rank : 66)	NC score	0.009456 (rank : 128)
Query Neighborhood Hits	148	Target Neighborhood Hits	174	Shared Neighborhood Hits	2
SwissProt Accessions	O94851, Q7Z3A8	Gene names	MICAL2, KIAA0750
Domain Architecture
Description	Protein MICAL-2.

RAI14_HUMAN
θ value	1.81305 (rank : 67)	NC score	0.002397 (rank : 155)
Query Neighborhood Hits	148	Target Neighborhood Hits	1367	Shared Neighborhood Hits	16
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

RNF6_HUMAN
θ value	1.81305 (rank : 68)	NC score	0.025148 (rank : 82)
Query Neighborhood Hits	148	Target Neighborhood Hits	157	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y252, Q9UF41	Gene names	RNF6
Domain Architecture
Description	RING finger protein 6 (RING-H2 protein).

SYP2L_MOUSE
θ value	1.81305 (rank : 69)	NC score	0.014529 (rank : 98)
Query Neighborhood Hits	148	Target Neighborhood Hits	289	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

ARHGC_MOUSE
θ value	2.36792 (rank : 70)	NC score	0.008537 (rank : 130)
Query Neighborhood Hits	148	Target Neighborhood Hits	344	Shared Neighborhood Hits	8
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARMC6_HUMAN
θ value	2.36792 (rank : 71)	NC score	0.021050 (rank : 88)
Query Neighborhood Hits	148	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	Q6NXE6, O94999, Q9BTH5	Gene names	ARMC6
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing protein 6.

DNJC3_HUMAN
θ value	2.36792 (rank : 72)	NC score	0.016201 (rank : 94)
Query Neighborhood Hits	148	Target Neighborhood Hits	223	Shared Neighborhood Hits	5
SwissProt Accessions	Q13217, Q86WT9, Q8N4N2	Gene names	DNAJC3, P58IPK, PRKRI
Domain Architecture	No domain graphic available
Description	DnaJ homolog subfamily C member 3 (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor p58) (Protein kinase inhibitor of 58 kDa).

KR104_HUMAN
θ value	2.36792 (rank : 73)	NC score	0.013940 (rank : 99)
Query Neighborhood Hits	148	Target Neighborhood Hits	313	Shared Neighborhood Hits	13
SwissProt Accessions	P60372	Gene names	KRTAP10-4, KAP10.4, KAP18-4, KRTAP10.4, KRTAP18-4, KRTAP18.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-4 (Keratin-associated protein 10.4) (High sulfur keratin-associated protein 10.4) (Keratin-associated protein 18-4) (Keratin-associated protein 18.4).

PEX6_MOUSE
θ value	2.36792 (rank : 74)	NC score	0.007363 (rank : 139)
Query Neighborhood Hits	148	Target Neighborhood Hits	94	Shared Neighborhood Hits	2
SwissProt Accessions	Q99LC9, Q6YNQ9	Gene names	Pex6
Domain Architecture	No domain graphic available
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).

RN185_HUMAN
θ value	2.36792 (rank : 75)	NC score	0.046787 (rank : 60)
Query Neighborhood Hits	148	Target Neighborhood Hits	213	Shared Neighborhood Hits	24
SwissProt Accessions	Q96GF1, Q8N900	Gene names	RNF185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

RN185_MOUSE
θ value	2.36792 (rank : 76)	NC score	0.045896 (rank : 62)
Query Neighborhood Hits	148	Target Neighborhood Hits	211	Shared Neighborhood Hits	22
SwissProt Accessions	Q91YT2, Q6ZWS3	Gene names	Rnf185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

STX4_MOUSE
θ value	2.36792 (rank : 77)	NC score	0.014659 (rank : 97)
Query Neighborhood Hits	148	Target Neighborhood Hits	312	Shared Neighborhood Hits	8
SwissProt Accessions	P70452	Gene names	Stx4, Stx4a
Domain Architecture
Description	Syntaxin-4.

TF65_MOUSE
θ value	2.36792 (rank : 78)	NC score	0.013195 (rank : 104)
Query Neighborhood Hits	148	Target Neighborhood Hits	66	Shared Neighborhood Hits	4
SwissProt Accessions	Q04207, Q62025	Gene names	Rela, Nfkb3
Domain Architecture
Description	Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit).

WIF1_MOUSE
θ value	2.36792 (rank : 79)	NC score	0.011372 (rank : 116)
Query Neighborhood Hits	148	Target Neighborhood Hits	393	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WUA1	Gene names	Wif1
Domain Architecture
Description	Wnt inhibitory factor 1 precursor (WIF-1).

ADDB_MOUSE
θ value	3.0926 (rank : 80)	NC score	0.009120 (rank : 129)
Query Neighborhood Hits	148	Target Neighborhood Hits	574	Shared Neighborhood Hits	7
SwissProt Accessions	Q9QYB8, Q3U0E1, Q80VH9, Q8C1C4, Q9CXE3, Q9JLE5, Q9QYB7	Gene names	Add2
Domain Architecture
Description	Beta-adducin (Erythrocyte adducin subunit beta) (Add97).

CF049_HUMAN
θ value	3.0926 (rank : 81)	NC score	0.015092 (rank : 96)
Query Neighborhood Hits	148	Target Neighborhood Hits	123	Shared Neighborhood Hits	4
SwissProt Accessions	Q2TBC4, Q5T3D4, Q9NSV1	Gene names	C6orf49
Domain Architecture	No domain graphic available
Description	Protein C6orf49.

KR105_HUMAN
θ value	3.0926 (rank : 82)	NC score	0.015150 (rank : 95)
Query Neighborhood Hits	148	Target Neighborhood Hits	271	Shared Neighborhood Hits	19
SwissProt Accessions	P60370, Q70LJ3	Gene names	KRTAP10-5, KAP10.5, KAP18-5, KRTAP10.5, KRTAP18-5, KRTAP18.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-5 (Keratin-associated protein 10.5) (High sulfur keratin-associated protein 10.5) (Keratin-associated protein 18-5) (Keratin-associated protein 18.5).

NIPBL_HUMAN
θ value	3.0926 (rank : 83)	NC score	0.007552 (rank : 138)
Query Neighborhood Hits	148	Target Neighborhood Hits	1311	Shared Neighborhood Hits	21
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

PPR3D_HUMAN
θ value	3.0926 (rank : 84)	NC score	0.026264 (rank : 80)
Query Neighborhood Hits	148	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	O95685, Q6DK02	Gene names	PPP1R3D, PPP1R6
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 3D (Protein phosphatase 1, regulatory subunit 6) (Protein phosphatase 1-binding subunit R6).

SEL1L_MOUSE
θ value	3.0926 (rank : 85)	NC score	0.013683 (rank : 101)
Query Neighborhood Hits	148	Target Neighborhood Hits	62	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z2G6, Q9DBD8	Gene names	Sel1l, Sel1h
Domain Architecture
Description	Sel-1 homolog precursor (Suppressor of lin-12-like protein) (Sel-1L).

TRIM9_MOUSE
θ value	3.0926 (rank : 86)	NC score	0.036595 (rank : 69)
Query Neighborhood Hits	148	Target Neighborhood Hits	274	Shared Neighborhood Hits	11
SwissProt Accessions	Q8C7M3, Q6ZQE5, Q80WT6, Q8C7Z4, Q8CC32, Q8CEG2, Q99PQ3	Gene names	Trim9, Kiaa0282
Domain Architecture
Description	Tripartite motif-containing protein 9.

AAKG3_MOUSE
θ value	4.03905 (rank : 87)	NC score	0.011004 (rank : 120)
Query Neighborhood Hits	148	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BGM7, Q80WK8, Q8CJ41	Gene names	Prkag3
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase subunit gamma-3 (AMPK gamma-3 chain) (AMPK gamma3).

ATS13_MOUSE
θ value	4.03905 (rank : 88)	NC score	0.004566 (rank : 147)
Query Neighborhood Hits	148	Target Neighborhood Hits	227	Shared Neighborhood Hits	6
SwissProt Accessions	Q769J6, Q76LW1	Gene names	Adamts13
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

CF182_MOUSE
θ value	4.03905 (rank : 89)	NC score	0.009647 (rank : 126)
Query Neighborhood Hits	148	Target Neighborhood Hits	551	Shared Neighborhood Hits	9
SwissProt Accessions	Q8VDS7, Q9CZE0, Q9D5A1	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf182 homolog.

KRA58_HUMAN
θ value	4.03905 (rank : 90)	NC score	0.011358 (rank : 117)
Query Neighborhood Hits	148	Target Neighborhood Hits	324	Shared Neighborhood Hits	13
SwissProt Accessions	O75690, Q6L8G7, Q6UTX6	Gene names	KRTAP5-8, KAP5.8, KRTAP5.8, UHSKB
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-8 (Keratin-associated protein 5.8) (Ultrahigh sulfur keratin-associated protein 5.8) (Keratin, ultra high-sulfur matrix protein B) (UHS keratin B) (UHS KerB).

MKRN1_MOUSE
θ value	4.03905 (rank : 91)	NC score	0.033149 (rank : 72)
Query Neighborhood Hits	148	Target Neighborhood Hits	141	Shared Neighborhood Hits	18
SwissProt Accessions	Q9QXP6	Gene names	Mkrn1
Domain Architecture
Description	Makorin-1.

PLCB3_HUMAN
θ value	4.03905 (rank : 92)	NC score	0.008062 (rank : 133)
Query Neighborhood Hits	148	Target Neighborhood Hits	445	Shared Neighborhood Hits	9
SwissProt Accessions	Q01970	Gene names	PLCB3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

PLXA4_HUMAN
θ value	4.03905 (rank : 93)	NC score	0.006802 (rank : 141)
Query Neighborhood Hits	148	Target Neighborhood Hits	106	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCM2, Q6UWC6, Q6ZW89, Q8N969, Q8ND00, Q8NEN3, Q9NTD4	Gene names	PLXNA4, KIAA1550, PLXNA4A, PLXNA4B
Domain Architecture	No domain graphic available
Description	Plexin-A4 precursor.

RGS12_HUMAN
θ value	4.03905 (rank : 94)	NC score	0.007697 (rank : 137)
Query Neighborhood Hits	148	Target Neighborhood Hits	333	Shared Neighborhood Hits	5
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

RNF5_MOUSE
θ value	4.03905 (rank : 95)	NC score	0.049828 (rank : 59)
Query Neighborhood Hits	148	Target Neighborhood Hits	206	Shared Neighborhood Hits	20
SwissProt Accessions	O35445	Gene names	Rnf5, Ng2
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (RING finger protein 5).

RTN2_MOUSE
θ value	4.03905 (rank : 96)	NC score	0.013913 (rank : 100)
Query Neighborhood Hits	148	Target Neighborhood Hits	48	Shared Neighborhood Hits	8
SwissProt Accessions	O70622, O70620	Gene names	Rtn2, Nspl1
Domain Architecture
Description	Reticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like protein 1) (NSPLI).

THUM1_MOUSE
θ value	4.03905 (rank : 97)	NC score	0.017396 (rank : 91)
Query Neighborhood Hits	148	Target Neighborhood Hits	55	Shared Neighborhood Hits	2
SwissProt Accessions	Q99J36, Q3U6Y3	Gene names	Thumpd1
Domain Architecture
Description	THUMP domain-containing protein 1.

ABLM1_MOUSE
θ value	5.27518 (rank : 98)	NC score	0.013120 (rank : 106)
Query Neighborhood Hits	148	Target Neighborhood Hits	356	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K4G5, Q80U86, Q8BIR9, Q8K4G3, Q8K4G4	Gene names	Ablim1, Ablim, Kiaa0059
Domain Architecture	No domain graphic available
Description	Actin-binding LIM protein 1 (Actin-binding LIM protein family member 1) (abLIM-1).

AGRIN_HUMAN
θ value	5.27518 (rank : 99)	NC score	0.007839 (rank : 135)
Query Neighborhood Hits	148	Target Neighborhood Hits	582	Shared Neighborhood Hits	19
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

APLP1_MOUSE
θ value	5.27518 (rank : 100)	NC score	0.010390 (rank : 122)
Query Neighborhood Hits	148	Target Neighborhood Hits	130	Shared Neighborhood Hits	4
SwissProt Accessions	Q03157, Q8VC38	Gene names	Aplp1
Domain Architecture
Description	Amyloid-like protein 1 precursor (APLP) (APLP-1) [Contains: C30].

EGFL7_HUMAN
θ value	5.27518 (rank : 101)	NC score	0.010156 (rank : 124)
Query Neighborhood Hits	148	Target Neighborhood Hits	325	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UHF1, Q5M7Y5, Q5VUD5, Q96EG0	Gene names	EGFL7, MEGF7
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 7 precursor (Multiple EGF-like domain protein 7) (Multiple epidermal growth factor-like domain protein 7) (Vascular endothelial statin) (VE-statin) (NOTCH4-like protein) (ZNEU1).

ELL3_MOUSE
θ value	5.27518 (rank : 102)	NC score	0.013053 (rank : 107)
Query Neighborhood Hits	148	Target Neighborhood Hits	47	Shared Neighborhood Hits	3
SwissProt Accessions	Q80VR2	Gene names	Ell3
Domain Architecture
Description	RNA polymerase II elongation factor ELL3.

EST1A_MOUSE
θ value	5.27518 (rank : 103)	NC score	0.012267 (rank : 113)
Query Neighborhood Hits	148	Target Neighborhood Hits	138	Shared Neighborhood Hits	4
SwissProt Accessions	P61406, Q5NC64	Gene names	Est1a, Kiaa0732
Domain Architecture
Description	Telomerase-binding protein EST1A (Ever shorter telomeres 1A) (Telomerase subunit EST1A) (EST1-like protein A).

FAS_MOUSE
θ value	5.27518 (rank : 104)	NC score	0.009548 (rank : 127)
Query Neighborhood Hits	148	Target Neighborhood Hits	76	Shared Neighborhood Hits	2
SwissProt Accessions	P19096, Q6PB72, Q8C4Z0, Q9EQR0	Gene names	Fasn
Domain Architecture	No domain graphic available
Description	Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S- acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S- malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.10); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)].

IWS1_HUMAN
θ value	5.27518 (rank : 105)	NC score	0.012782 (rank : 111)
Query Neighborhood Hits	148	Target Neighborhood Hits	1241	Shared Neighborhood Hits	23
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

MAGD2_HUMAN
θ value	5.27518 (rank : 106)	NC score	0.005038 (rank : 146)
Query Neighborhood Hits	148	Target Neighborhood Hits	95	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UNF1, O76058, Q5BJF3, Q8NAL6, Q9H218, Q9P0U9, Q9UM52	Gene names	MAGED2, BCG1
Domain Architecture
Description	Melanoma-associated antigen D2 (MAGE-D2 antigen) (MAGE-D) (Breast cancer-associated gene 1 protein) (BCG-1) (11B6) (Hepatocellular carcinoma-associated protein JCL-1).

MKRN1_HUMAN
θ value	5.27518 (rank : 107)	NC score	0.032506 (rank : 75)
Query Neighborhood Hits	148	Target Neighborhood Hits	141	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UHC7, Q6GSF1, Q9H0G0, Q9UEZ7	Gene names	MKRN1, RNF61
Domain Architecture
Description	Makorin-1 (RING finger protein 61).

MKRN4_HUMAN
θ value	5.27518 (rank : 108)	NC score	0.034100 (rank : 71)
Query Neighborhood Hits	148	Target Neighborhood Hits	147	Shared Neighborhood Hits	19
SwissProt Accessions	Q13434	Gene names	MKRN4, RNF64, ZNF127L1
Domain Architecture	No domain graphic available
Description	Makorin-4 (Zinc finger protein 127-Xp) (ZNF127-Xp) (RING finger protein 64).

NBN_MOUSE
θ value	5.27518 (rank : 109)	NC score	0.012802 (rank : 109)
Query Neighborhood Hits	148	Target Neighborhood Hits	125	Shared Neighborhood Hits	5
SwissProt Accessions	Q9R207, O88981, Q3UY57, Q811I6, Q8CCY0, Q9R1X1	Gene names	Nbn, Nbs1
Domain Architecture	No domain graphic available
Description	Nibrin (Nijmegen breakage syndrome protein 1 homolog) (Cell cycle regulatory protein p95).

PYGO1_MOUSE
θ value	5.27518 (rank : 110)	NC score	0.013007 (rank : 108)
Query Neighborhood Hits	148	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D0P5	Gene names	Pygo1
Domain Architecture
Description	Pygopus homolog 1.

SEC63_MOUSE
θ value	5.27518 (rank : 111)	NC score	0.023253 (rank : 85)
Query Neighborhood Hits	148	Target Neighborhood Hits	601	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VHE0, Q8VEB9	Gene names	Sec63, Sec63l
Domain Architecture
Description	Translocation protein SEC63 homolog.

SRRM2_HUMAN
θ value	5.27518 (rank : 112)	NC score	0.021408 (rank : 87)
Query Neighborhood Hits	148	Target Neighborhood Hits	1296	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

TAOK3_HUMAN
θ value	5.27518 (rank : 113)	NC score	-0.002035 (rank : 160)
Query Neighborhood Hits	148	Target Neighborhood Hits	1494	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

TAOK3_MOUSE
θ value	5.27518 (rank : 114)	NC score	-0.001888 (rank : 159)
Query Neighborhood Hits	148	Target Neighborhood Hits	1458	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

MKRN3_HUMAN
θ value	6.88961 (rank : 115)	NC score	0.039774 (rank : 67)
Query Neighborhood Hits	148	Target Neighborhood Hits	165	Shared Neighborhood Hits	21
SwissProt Accessions	Q13064	Gene names	MKRN3, RNF63, ZNF127
Domain Architecture
Description	Makorin-3 (Zinc finger protein 127) (RING finger protein 63).

MKRN3_MOUSE
θ value	6.88961 (rank : 116)	NC score	0.036587 (rank : 70)
Query Neighborhood Hits	148	Target Neighborhood Hits	137	Shared Neighborhood Hits	20
SwissProt Accessions	Q60764, Q7TQE4	Gene names	Mkrn3, Zfp127, Znf127
Domain Architecture
Description	Makorin-3 (Zinc finger protein 127).

NC6IP_HUMAN
θ value	6.88961 (rank : 117)	NC score	0.011169 (rank : 119)
Query Neighborhood Hits	148	Target Neighborhood Hits	116	Shared Neighborhood Hits	5
SwissProt Accessions	Q96RS0, Q5GH23, Q8TDG9, Q96QU3, Q9H5V3	Gene names	NCOA6IP, PIMT
Domain Architecture	No domain graphic available
Description	Putative RNA methyltransferase NCOA6IP (EC 2.1.1.-) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIPMT) (PIMT) (CLL-associated antigen KW-2) (Hepatocellular carcinoma-associated antigen 137) (HCA137).

PA2G3_HUMAN
θ value	6.88961 (rank : 118)	NC score	0.016999 (rank : 92)
Query Neighborhood Hits	148	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NZ20, O95768	Gene names	PLA2G3
Domain Architecture
Description	Group 3 secretory phospholipase A2 precursor (EC 3.1.1.4) (Group III secretory phospholipase A2) (Phosphatidylcholine 2-acylhydrolase GIII) (GIII sPLA2).

PACN3_HUMAN
θ value	6.88961 (rank : 119)	NC score	0.004217 (rank : 149)
Query Neighborhood Hits	148	Target Neighborhood Hits	385	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PTN23_HUMAN
θ value	6.88961 (rank : 120)	NC score	0.002710 (rank : 153)
Query Neighborhood Hits	148	Target Neighborhood Hits	646	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

RN141_HUMAN
θ value	6.88961 (rank : 121)	NC score	0.025274 (rank : 81)
Query Neighborhood Hits	148	Target Neighborhood Hits	199	Shared Neighborhood Hits	22
SwissProt Accessions	Q8WVD5, Q9NZB4	Gene names	RNF141, ZNF230
Domain Architecture	No domain graphic available
Description	RING finger protein 141 (Zinc finger protein 230).

RNF5_HUMAN
θ value	6.88961 (rank : 122)	NC score	0.046285 (rank : 61)
Query Neighborhood Hits	148	Target Neighborhood Hits	206	Shared Neighborhood Hits	20
SwissProt Accessions	Q99942, Q9UMQ2	Gene names	RNF5, G16, NG2, RMA1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (HsRma1) (RING finger protein 5) (Protein G16).

SON_MOUSE
θ value	6.88961 (rank : 123)	NC score	0.005418 (rank : 144)
Query Neighborhood Hits	148	Target Neighborhood Hits	957	Shared Neighborhood Hits	16
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

TMPS6_MOUSE
θ value	6.88961 (rank : 124)	NC score	0.000107 (rank : 157)
Query Neighborhood Hits	148	Target Neighborhood Hits	341	Shared Neighborhood Hits	7
SwissProt Accessions	Q9DBI0, Q6PF94	Gene names	Tmprss6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

ASPH_HUMAN
θ value	8.99809 (rank : 125)	NC score	0.011841 (rank : 115)
Query Neighborhood Hits	148	Target Neighborhood Hits	158	Shared Neighborhood Hits	5
SwissProt Accessions	Q12797	Gene names	ASPH
Domain Architecture
Description	Aspartyl/asparaginyl beta-hydroxylase (EC 1.14.11.16) (Aspartate beta- hydroxylase) (ASP beta-hydroxylase) (Peptide-aspartate beta- dioxygenase).

BRD8_HUMAN
θ value	8.99809 (rank : 126)	NC score	0.005386 (rank : 145)
Query Neighborhood Hits	148	Target Neighborhood Hits	292	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H0E9, O43178, Q15355, Q59GN0, Q969M9	Gene names	BRD8, SMAP
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8 (p120) (Skeletal muscle abundant protein) (Thyroid hormone receptor coactivating protein 120kDa) (TrCP120).

CELR1_HUMAN
θ value	8.99809 (rank : 127)	NC score	0.000347 (rank : 156)
Query Neighborhood Hits	148	Target Neighborhood Hits	613	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NYQ6, O95722, Q5TH47, Q9BWQ5, Q9Y506, Q9Y526	Gene names	CELSR1, CDHF9, FMI2
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 1 precursor (Flamingo homolog 2) (hFmi2).

CO7A1_HUMAN
θ value	8.99809 (rank : 128)	NC score	0.002471 (rank : 154)
Query Neighborhood Hits	148	Target Neighborhood Hits	807	Shared Neighborhood Hits	8
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

CT077_HUMAN
θ value	8.99809 (rank : 129)	NC score	0.007703 (rank : 136)
Query Neighborhood Hits	148	Target Neighborhood Hits	155	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NQG5	Gene names	C20orf77
Domain Architecture
Description	Uncharacterized protein C20orf77.

FBN1_HUMAN
θ value	8.99809 (rank : 130)	NC score	0.008497 (rank : 131)
Query Neighborhood Hits	148	Target Neighborhood Hits	557	Shared Neighborhood Hits	21
SwissProt Accessions	P35555, Q15972, Q75N87	Gene names	FBN1, FBN
Domain Architecture
Description	Fibrillin-1 precursor.

GCC2_MOUSE
θ value	8.99809 (rank : 131)	NC score	0.000102 (rank : 158)
Query Neighborhood Hits	148	Target Neighborhood Hits	1619	Shared Neighborhood Hits	16
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

IGF1R_HUMAN
θ value	8.99809 (rank : 132)	NC score	-0.002797 (rank : 161)
Query Neighborhood Hits	148	Target Neighborhood Hits	977	Shared Neighborhood Hits	12
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

KRA24_HUMAN
θ value	8.99809 (rank : 133)	NC score	0.012794 (rank : 110)
Query Neighborhood Hits	148	Target Neighborhood Hits	192	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BYR9, Q495J2	Gene names	KRTAP2-4, KAP2.4, KRTAP2.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 2-4 (Keratin-associated protein 2.4) (High sulfur keratin-associated protein 2.4).

KRA51_HUMAN
θ value	8.99809 (rank : 134)	NC score	0.008250 (rank : 132)
Query Neighborhood Hits	148	Target Neighborhood Hits	288	Shared Neighborhood Hits	12
SwissProt Accessions	Q6L8H4	Gene names	KRTAP5-1, KAP5.1, KRTAP5.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-1 (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1).

KRA53_HUMAN
θ value	8.99809 (rank : 135)	NC score	0.008016 (rank : 134)
Query Neighborhood Hits	148	Target Neighborhood Hits	331	Shared Neighborhood Hits	14
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

KRA56_HUMAN
θ value	8.99809 (rank : 136)	NC score	0.011282 (rank : 118)
Query Neighborhood Hits	148	Target Neighborhood Hits	207	Shared Neighborhood Hits	10
SwissProt Accessions	Q6L8G9	Gene names	KRTAP5-6, KAP5.6, KRTAP5.6
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-6 (Keratin-associated protein 5.6) (Ultrahigh sulfur keratin-associated protein 5.6).

NFKB1_HUMAN
θ value	8.99809 (rank : 137)	NC score	0.003824 (rank : 150)
Query Neighborhood Hits	148	Target Neighborhood Hits	306	Shared Neighborhood Hits	6
SwissProt Accessions	P19838, Q68D84, Q86V43, Q8N4X7, Q9NZC0	Gene names	NFKB1
Domain Architecture
Description	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) [Contains: Nuclear factor NF-kappa-B p50 subunit].

NOTC1_HUMAN
θ value	8.99809 (rank : 138)	NC score	0.006819 (rank : 140)
Query Neighborhood Hits	148	Target Neighborhood Hits	906	Shared Neighborhood Hits	24
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

NOTC1_MOUSE
θ value	8.99809 (rank : 139)	NC score	0.010157 (rank : 123)
Query Neighborhood Hits	148	Target Neighborhood Hits	916	Shared Neighborhood Hits	23
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

PI4KB_MOUSE
θ value	8.99809 (rank : 140)	NC score	0.005487 (rank : 143)
Query Neighborhood Hits	148	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

RN122_HUMAN
θ value	8.99809 (rank : 141)	NC score	0.026557 (rank : 79)
Query Neighborhood Hits	148	Target Neighborhood Hits	121	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H9V4, Q52LK3	Gene names	RNF122
Domain Architecture	No domain graphic available
Description	RING finger protein 122.

RN122_MOUSE
θ value	8.99809 (rank : 142)	NC score	0.024303 (rank : 83)
Query Neighborhood Hits	148	Target Neighborhood Hits	121	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BP31, Q80VA7, Q8BGD3	Gene names	Rnf122
Domain Architecture	No domain graphic available
Description	RING finger protein 122.

RN141_MOUSE
θ value	8.99809 (rank : 143)	NC score	0.023941 (rank : 84)
Query Neighborhood Hits	148	Target Neighborhood Hits	200	Shared Neighborhood Hits	22
SwissProt Accessions	Q99MB7, Q9D040, Q9D5C4, Q9D9L0	Gene names	Rnf141, Znf230
Domain Architecture	No domain graphic available
Description	RING finger protein 141 (Zinc finger protein 230).

STA13_MOUSE
θ value	8.99809 (rank : 144)	NC score	0.003766 (rank : 151)
Query Neighborhood Hits	148	Target Neighborhood Hits	89	Shared Neighborhood Hits	3
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

SYT14_MOUSE
θ value	8.99809 (rank : 145)	NC score	0.004446 (rank : 148)
Query Neighborhood Hits	148	Target Neighborhood Hits	82	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TN84	Gene names	Syt14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

TGON2_HUMAN
θ value	8.99809 (rank : 146)	NC score	0.002980 (rank : 152)
Query Neighborhood Hits	148	Target Neighborhood Hits	1037	Shared Neighborhood Hits	15
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

ZBT40_HUMAN
θ value	8.99809 (rank : 147)	NC score	-0.003790 (rank : 162)
Query Neighborhood Hits	148	Target Neighborhood Hits	949	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NUA8, O75066, Q5TFU5, Q8N1R1	Gene names	ZBTB40, KIAA0478
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 40.

ZN425_HUMAN
θ value	8.99809 (rank : 148)	NC score	-0.003975 (rank : 163)
Query Neighborhood Hits	148	Target Neighborhood Hits	795	Shared Neighborhood Hits	5
SwissProt Accessions	Q6IV72	Gene names	ZNF425
Domain Architecture	No domain graphic available
Description	Zinc finger protein 425.

CUL1_HUMAN
θ value	θ > 10 (rank : 149)	NC score	0.077021 (rank : 37)
Query Neighborhood Hits	148	Target Neighborhood Hits	38	Shared Neighborhood Hits	7
SwissProt Accessions	Q13616, O60719, Q8IYW1	Gene names	CUL1
Domain Architecture
Description	Cullin-1 (CUL-1).

CUL1_MOUSE
θ value	θ > 10 (rank : 150)	NC score	0.077015 (rank : 38)
Query Neighborhood Hits	148	Target Neighborhood Hits	38	Shared Neighborhood Hits	7
SwissProt Accessions	Q9WTX6, Q9WUI7	Gene names	Cul1
Domain Architecture
Description	Cullin-1 (CUL-1).

CUL2_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.050572 (rank : 56)
Query Neighborhood Hits	148	Target Neighborhood Hits	36	Shared Neighborhood Hits	5
SwissProt Accessions	Q13617, O00200, Q9UNF9	Gene names	CUL2
Domain Architecture
Description	Cullin-2 (CUL-2).

CUL2_MOUSE
θ value	θ > 10 (rank : 152)	NC score	0.050457 (rank : 57)
Query Neighborhood Hits	148	Target Neighborhood Hits	29	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D4H8, Q3TUR8	Gene names	Cul2
Domain Architecture
Description	Cullin-2 (CUL-2).

EDD1_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.052536 (rank : 50)
Query Neighborhood Hits	148	Target Neighborhood Hits	170	Shared Neighborhood Hits	4
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

EDD1_MOUSE
θ value	θ > 10 (rank : 154)	NC score	0.052612 (rank : 49)
Query Neighborhood Hits	148	Target Neighborhood Hits	167	Shared Neighborhood Hits	4
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

HECD2_MOUSE
θ value	θ > 10 (rank : 155)	NC score	0.050269 (rank : 58)
Query Neighborhood Hits	148	Target Neighborhood Hits	38	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HERC3_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.051437 (rank : 53)
Query Neighborhood Hits	148	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

HERC5_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.052672 (rank : 48)
Query Neighborhood Hits	148	Target Neighborhood Hits	66	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HUWE1_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.050942 (rank : 54)
Query Neighborhood Hits	148	Target Neighborhood Hits	443	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	θ > 10 (rank : 159)	NC score	0.050898 (rank : 55)
Query Neighborhood Hits	148	Target Neighborhood Hits	406	Shared Neighborhood Hits	12
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

TRIPC_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.056386 (rank : 44)
Query Neighborhood Hits	148	Target Neighborhood Hits	319	Shared Neighborhood Hits	11
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

UBE3A_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.051460 (rank : 52)
Query Neighborhood Hits	148	Target Neighborhood Hits	49	Shared Neighborhood Hits	4
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3C_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.053263 (rank : 46)
Query Neighborhood Hits	148	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
θ value	θ > 10 (rank : 163)	NC score	0.052934 (rank : 47)
Query Neighborhood Hits	148	Target Neighborhood Hits	48	Shared Neighborhood Hits	4
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

Hits sorted by NC score

PARC_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	148	Target Neighborhood Hits	148	Shared Neighborhood Hits	148
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).

PARC_MOUSE
NC score	0.986191 (rank : 2)	θ value	0 (rank : 3)
Query Neighborhood Hits	148	Target Neighborhood Hits	114	Shared Neighborhood Hits	64
SwissProt Accessions	Q80TT8, Q8BKL9, Q8CGC0, Q8R363	Gene names	Parc, Kiaa0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein.

CUL7_HUMAN
NC score	0.794754 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	148	Target Neighborhood Hits	41	Shared Neighborhood Hits	10
SwissProt Accessions	Q14999, Q5T654	Gene names	CUL7, KIAA0076
Domain Architecture
Description	Cullin-7 (CUL-7).

ARI2_HUMAN
NC score	0.704588 (rank : 4)	θ value	2.67181e-44 (rank : 4)
Query Neighborhood Hits	148	Target Neighborhood Hits	113	Shared Neighborhood Hits	40
SwissProt Accessions	O95376, Q9HBZ6, Q9UEM9	Gene names	ARIH2, ARI2, TRIAD1
Domain Architecture
Description	Protein ariadne-2 homolog (ARI-2) (Triad1 protein).

ARI2_MOUSE
NC score	0.704003 (rank : 5)	θ value	4.55743e-44 (rank : 5)
Query Neighborhood Hits	148	Target Neighborhood Hits	106	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Z1K6	Gene names	Arih2, Ari2, Triad1, Uip48
Domain Architecture
Description	Protein ariadne-2 homolog (ARI-2) (Triad1 protein) (UbcM4-interacting protein 48).

ARI1_HUMAN
NC score	0.688363 (rank : 6)	θ value	2.26708e-35 (rank : 6)
Query Neighborhood Hits	148	Target Neighborhood Hits	71	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y4X5, O76026, Q9H3T6, Q9UEN0, Q9UP39	Gene names	ARIH1, ARI, UBCH7BP
Domain Architecture
Description	Protein ariadne-1 homolog (ARI-1) (Ubiquitin-conjugating enzyme E2- binding protein 1) (UbcH7-binding protein) (UbcM4-interacting protein) (HHARI) (H7-AP2) (MOP-6).

ARI1_MOUSE
NC score	0.688230 (rank : 7)	θ value	2.26708e-35 (rank : 7)
Query Neighborhood Hits	148	Target Neighborhood Hits	71	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z1K5, Q6PF92	Gene names	Arih1, Ari, Ubch7bp, Uip77
Domain Architecture	No domain graphic available
Description	Protein ariadne-1 homolog (ARI-1) (Ubiquitin-conjugating enzyme E2- binding protein 1) (UbcH7-binding protein) (UbcM4-interacting protein 77).

RNF14_MOUSE
NC score	0.593726 (rank : 8)	θ value	1.63225e-17 (rank : 13)
Query Neighborhood Hits	148	Target Neighborhood Hits	69	Shared Neighborhood Hits	25
SwissProt Accessions	Q9JI90, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89	Gene names	Rnf14, Ara54, Triad2
Domain Architecture
Description	RING finger protein 14 (Androgen receptor-associated protein 54) (Triad2 protein).

RNF14_HUMAN
NC score	0.592242 (rank : 9)	θ value	4.29542e-18 (rank : 11)
Query Neighborhood Hits	148	Target Neighborhood Hits	70	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UBS8, O94793, Q6IBV0	Gene names	RNF14, ARA54
Domain Architecture
Description	RING finger protein 14 (Androgen receptor-associated protein 54) (Triad2 protein) (HFB30).

UB7I4_MOUSE
NC score	0.572828 (rank : 10)	θ value	2.20605e-14 (rank : 17)
Query Neighborhood Hits	148	Target Neighborhood Hits	59	Shared Neighborhood Hits	26
SwissProt Accessions	Q925F3, Q6A0B4	Gene names	Rnf144, Kiaa0161, Ubce7ip4, Uip4
Domain Architecture
Description	Ubiquitin-conjugating enzyme 7-interacting protein 4 (UbcM4- interacting protein 4) (RING finger protein 144).

UB7I4_HUMAN
NC score	0.569648 (rank : 11)	θ value	6.41864e-14 (rank : 18)
Query Neighborhood Hits	148	Target Neighborhood Hits	54	Shared Neighborhood Hits	26
SwissProt Accessions	P50876	Gene names	RNF144, KIAA0161, UBCE7IP4
Domain Architecture
Description	Ubiquitin-conjugating enzyme 7-interacting protein 4 (UbcM4- interacting protein 4) (RING finger protein 144).

IBRD3_HUMAN
NC score	0.567469 (rank : 12)	θ value	4.02038e-16 (rank : 14)
Query Neighborhood Hits	148	Target Neighborhood Hits	70	Shared Neighborhood Hits	29
SwissProt Accessions	Q6ZMZ0, Q6P6A4	Gene names	IBRDC3
Domain Architecture	No domain graphic available
Description	IBR domain-containing protein 3.

IBRD2_MOUSE
NC score	0.551799 (rank : 13)	θ value	1.33837e-11 (rank : 19)
Query Neighborhood Hits	148	Target Neighborhood Hits	46	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BKD6, Q8BG97	Gene names	Ibrdc2
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase IBRDC2 (EC 6.3.2.-) (IBR domain-containing protein 2).

IBRD2_HUMAN
NC score	0.539059 (rank : 14)	θ value	1.47974e-10 (rank : 22)
Query Neighborhood Hits	148	Target Neighborhood Hits	55	Shared Neighborhood Hits	24
SwissProt Accessions	Q7Z419, Q6P4Q0, Q8N3R7, Q9BX38	Gene names	IBRDC2, P53RFP
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase IBRDC2 (EC 6.3.2.-) (IBR domain-containing protein 2) (p53-inducible RING finger protein).

RNF19_MOUSE
NC score	0.537188 (rank : 15)	θ value	8.95645e-16 (rank : 16)
Query Neighborhood Hits	148	Target Neighborhood Hits	96	Shared Neighborhood Hits	32
SwissProt Accessions	P50636, Q9QUJ5	Gene names	Rnf19, Geg-154, Xybp
Domain Architecture
Description	RING finger protein 19 (XY body protein) (XYbp) (Gametogenesis expressed protein GEG-154) (UBCM4-interacting protein 117) (UIP117).

RNF19_HUMAN
NC score	0.535592 (rank : 16)	θ value	8.95645e-16 (rank : 15)
Query Neighborhood Hits	148	Target Neighborhood Hits	105	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NV58, Q9H5H9, Q9H8M8, Q9UFG0, Q9UFX6, Q9Y4Y1	Gene names	RNF19
Domain Architecture
Description	RING finger protein 19 (Dorfin) (Double ring-finger protein) (p38 protein).

IBRD1_HUMAN
NC score	0.533604 (rank : 17)	θ value	2.61198e-07 (rank : 27)
Query Neighborhood Hits	148	Target Neighborhood Hits	62	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TC41, Q9BX48	Gene names	IBRDC1
Domain Architecture	No domain graphic available
Description	IBR domain-containing protein 1.

PRKN2_MOUSE
NC score	0.501651 (rank : 18)	θ value	5.08577e-11 (rank : 21)
Query Neighborhood Hits	148	Target Neighborhood Hits	69	Shared Neighborhood Hits	24
SwissProt Accessions	Q9WVS6, Q9ES22, Q9ES23	Gene names	Park2, Prkn
Domain Architecture	No domain graphic available
Description	Parkin (EC 6.3.2.-) (Ubiquitin E3 ligase PRKN).

PRKN2_HUMAN
NC score	0.499873 (rank : 19)	θ value	5.08577e-11 (rank : 20)
Query Neighborhood Hits	148	Target Neighborhood Hits	65	Shared Neighborhood Hits	24
SwissProt Accessions	O60260, Q5TFV8, Q6Q2I6, Q8NI41, Q8NI43, Q8NI44, Q8WW07	Gene names	PARK2, PRKN
Domain Architecture	No domain graphic available
Description	Parkin (EC 6.3.2.-) (Ubiquitin E3 ligase PRKN) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2).

UB7I3_MOUSE
NC score	0.441749 (rank : 20)	θ value	2.36244e-08 (rank : 25)
Query Neighborhood Hits	148	Target Neighborhood Hits	131	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WUB0	Gene names	Rbck1, Rbck, Ubce7ip3, Uip28
Domain Architecture
Description	RanBP-type and C3HC4-type zinc finger-containing protein 1 (Ubiquitin- conjugating enzyme 7-interacting protein 3) (UbcM4-interacting protein 28).

UB7I3_HUMAN
NC score	0.439187 (rank : 21)	θ value	1.53129e-07 (rank : 26)
Query Neighborhood Hits	148	Target Neighborhood Hits	136	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BYM8, O95623, Q96BS3, Q9BYM9	Gene names	RBCK1, C20orf18, RNF54, UBCE7IP3, XAP4
Domain Architecture
Description	RanBP-type and C3HC4-type zinc finger-containing protein 1 (Ubiquitin- conjugating enzyme 7-interacting protein 3) (Hepatitis B virus X- associated protein 4) (HBV-associated factor 4) (RING finger protein 54).

RNF31_HUMAN
NC score	0.423928 (rank : 22)	θ value	1.80886e-08 (rank : 24)
Query Neighborhood Hits	148	Target Neighborhood Hits	110	Shared Neighborhood Hits	25
SwissProt Accessions	Q96EP0, Q86VI2, Q8TEI0, Q96GB4, Q96NF1, Q9H5F1, Q9NWD2	Gene names	RNF31, ZIBRA
Domain Architecture
Description	RING finger protein 31 (Zinc in-between-RING-finger ubiquitin- associated domain protein).

RNF31_MOUSE
NC score	0.420591 (rank : 23)	θ value	1.38499e-08 (rank : 23)
Query Neighborhood Hits	148	Target Neighborhood Hits	113	Shared Neighborhood Hits	25
SwissProt Accessions	Q924T7	Gene names	Rnf31
Domain Architecture
Description	RING finger protein 31.

HECD3_HUMAN
NC score	0.356785 (rank : 24)	θ value	5.07402e-19 (rank : 10)
Query Neighborhood Hits	148	Target Neighborhood Hits	49	Shared Neighborhood Hits	9
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_MOUSE
NC score	0.356604 (rank : 25)	θ value	1.33526e-19 (rank : 8)
Query Neighborhood Hits	148	Target Neighborhood Hits	47	Shared Neighborhood Hits	10
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

UB7I1_HUMAN
NC score	0.309899 (rank : 26)	θ value	0.0252991 (rank : 36)
Query Neighborhood Hits	148	Target Neighborhood Hits	177	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NWF9, Q6Y691, Q75ML7, Q7Z2H7, Q7Z7C1, Q8NHW7, Q9NYT1	Gene names	UBCE7IP1, ZIN
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase TRIAD3 (EC 6.3.2.-) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (Zinc finger protein inhibiting NF-kappa-B) (Triad domain-containing protein 3).

UB7I1_MOUSE
NC score	0.307020 (rank : 27)	θ value	0.0961366 (rank : 39)
Query Neighborhood Hits	148	Target Neighborhood Hits	206	Shared Neighborhood Hits	27
SwissProt Accessions	P58283, Q3U493, Q3UE56, Q3UGM3, Q68FN0, Q6P1H8, Q6PWY5, Q8BN27, Q8C1U3	Gene names	Ubce7ip1, Triad3, Uip83, Zin
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase TRIAD3 (EC 6.3.2.-) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (UbcM4-interacting protein 83) (Triad domain- containing protein 3).

APC10_HUMAN
NC score	0.274878 (rank : 28)	θ value	0.00228821 (rank : 31)
Query Neighborhood Hits	148	Target Neighborhood Hits	10	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UM13, Q2V500, Q9UG51, Q9Y5R0	Gene names	ANAPC10, APC10
Domain Architecture
Description	Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10).

APC10_MOUSE
NC score	0.272998 (rank : 29)	θ value	0.00228821 (rank : 32)
Query Neighborhood Hits	148	Target Neighborhood Hits	9	Shared Neighborhood Hits	9
SwissProt Accessions	Q8K2H6, Q9CW24	Gene names	Anapc10, Apc10
Domain Architecture
Description	Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10).

HERC2_HUMAN
NC score	0.260986 (rank : 30)	θ value	1.74391e-19 (rank : 9)
Query Neighborhood Hits	148	Target Neighborhood Hits	163	Shared Neighborhood Hits	10
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_MOUSE
NC score	0.254636 (rank : 31)	θ value	5.60996e-18 (rank : 12)
Query Neighborhood Hits	148	Target Neighborhood Hits	167	Shared Neighborhood Hits	9
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

CUL4B_HUMAN
NC score	0.120236 (rank : 32)	θ value	4.1701e-05 (rank : 28)
Query Neighborhood Hits	148	Target Neighborhood Hits	80	Shared Neighborhood Hits	7
SwissProt Accessions	Q13620, Q6PIE4, Q6UP07, Q7Z673, Q9BY37, Q9UEB7, Q9UED7	Gene names	CUL4B, KIAA0695
Domain Architecture
Description	Cullin-4B (CUL-4B).

CUL4A_HUMAN
NC score	0.118721 (rank : 33)	θ value	0.00175202 (rank : 30)
Query Neighborhood Hits	148	Target Neighborhood Hits	40	Shared Neighborhood Hits	7
SwissProt Accessions	Q13619, O75834, Q589T6, Q5TC62, Q6UP08, Q9UP17	Gene names	CUL4A
Domain Architecture
Description	Cullin-4A (CUL-4A).

CUL4A_MOUSE
NC score	0.118158 (rank : 34)	θ value	0.000602161 (rank : 29)
Query Neighborhood Hits	148	Target Neighborhood Hits	31	Shared Neighborhood Hits	7
SwissProt Accessions	Q3TCH7, Q3THM3, Q91Z44	Gene names	Cul4a
Domain Architecture	No domain graphic available
Description	Cullin-4A (CUL-4A).

CUL3_MOUSE
NC score	0.084827 (rank : 35)	θ value	0.0252991 (rank : 34)
Query Neighborhood Hits	148	Target Neighborhood Hits	39	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JLV5	Gene names	Cul3
Domain Architecture
Description	Cullin-3 (CUL-3).

CUL3_HUMAN
NC score	0.084673 (rank : 36)	θ value	0.0252991 (rank : 33)
Query Neighborhood Hits	148	Target Neighborhood Hits	42	Shared Neighborhood Hits	8
SwissProt Accessions	Q13618, O75415, Q569L3, Q9UBI8, Q9UET7	Gene names	CUL3, KIAA0617
Domain Architecture
Description	Cullin-3 (CUL-3).

CUL1_HUMAN
NC score	0.077021 (rank : 37)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	148	Target Neighborhood Hits	38	Shared Neighborhood Hits	7
SwissProt Accessions	Q13616, O60719, Q8IYW1	Gene names	CUL1
Domain Architecture
Description	Cullin-1 (CUL-1).

CUL1_MOUSE
NC score	0.077015 (rank : 38)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	148	Target Neighborhood Hits	38	Shared Neighborhood Hits	7
SwissProt Accessions	Q9WTX6, Q9WUI7	Gene names	Cul1
Domain Architecture
Description	Cullin-1 (CUL-1).

TOPRS_MOUSE
NC score	0.072155 (rank : 39)	θ value	0.813845 (rank : 53)
Query Neighborhood Hits	148	Target Neighborhood Hits	263	Shared Neighborhood Hits	30
SwissProt Accessions	Q80Z37, Q3U5B5, Q3UPZ1, Q3USN3, Q3UZ55, Q8BXP2, Q8CFF5, Q8CGC8, Q920L3	Gene names	Topors
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

PEX10_HUMAN
NC score	0.071111 (rank : 40)	θ value	0.47712 (rank : 47)
Query Neighborhood Hits	148	Target Neighborhood Hits	255	Shared Neighborhood Hits	25
SwissProt Accessions	O60683, Q5T095, Q9BW90	Gene names	PEX10, RNF69
Domain Architecture
Description	Peroxisome assembly protein 10 (Peroxin-10) (Peroxisome biogenesis factor 10) (RING finger protein 69).

TOPRS_HUMAN
NC score	0.070819 (rank : 41)	θ value	0.813845 (rank : 52)
Query Neighborhood Hits	148	Target Neighborhood Hits	286	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NS56, O43273, Q6P987, Q9NS55, Q9UNR9	Gene names	TOPORS, LUN, TP53BPL
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

CNOT4_HUMAN
NC score	0.062314 (rank : 42)	θ value	0.163984 (rank : 41)
Query Neighborhood Hits	148	Target Neighborhood Hits	207	Shared Neighborhood Hits	6
SwissProt Accessions	O95628, O95339, O95627, Q8IYM7, Q8NCL0, Q9NPQ1, Q9NZN6	Gene names	CNOT4, NOT4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

CNOT4_MOUSE
NC score	0.059514 (rank : 43)	θ value	0.163984 (rank : 42)
Query Neighborhood Hits	148	Target Neighborhood Hits	277	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BT14, Q8CCR4, Q9CV74, Q9Z1D0	Gene names	Cnot4, Not4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

TRIPC_HUMAN
NC score	0.056386 (rank : 44)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	148	Target Neighborhood Hits	319	Shared Neighborhood Hits	11
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

CD177_HUMAN
NC score	0.054984 (rank : 45)	θ value	0.813845 (rank : 50)
Query Neighborhood Hits	148	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N6Q3, Q711Q2, Q8NCV9, Q96QH1, Q9HDA5	Gene names	CD177, NB1, PRV1
Domain Architecture	No domain graphic available
Description	CD177 antigen precursor (Polycythemia rubra vera protein 1) (PRV-1) (NB1 glycoprotein) (NB1 GP) (Human neutrophil alloantigen 2a) (HNA- 2a).

UBE3C_HUMAN
NC score	0.053263 (rank : 46)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	148	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
NC score	0.052934 (rank : 47)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	148	Target Neighborhood Hits	48	Shared Neighborhood Hits	4
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

HERC5_HUMAN
NC score	0.052672 (rank : 48)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	148	Target Neighborhood Hits	66	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

EDD1_MOUSE
NC score	0.052612 (rank : 49)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	148	Target Neighborhood Hits	167	Shared Neighborhood Hits	4
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

EDD1_HUMAN
NC score	0.052536 (rank : 50)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	148	Target Neighborhood Hits	170	Shared Neighborhood Hits	4
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

GOLI_HUMAN
NC score	0.051723 (rank : 51)	θ value	0.365318 (rank : 45)
Query Neighborhood Hits	148	Target Neighborhood Hits	137	Shared Neighborhood Hits	15
SwissProt Accessions	Q86XS8, Q641P9, Q6P177, Q7L2U2, Q9P0J9	Gene names	RNF130
Domain Architecture	No domain graphic available
Description	Goliath homolog precursor (RING finger protein 130).

UBE3A_HUMAN
NC score	0.051460 (rank : 52)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	148	Target Neighborhood Hits	49	Shared Neighborhood Hits	4
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

HERC3_HUMAN
NC score	0.051437 (rank : 53)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	148	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

HUWE1_HUMAN
NC score	0.050942 (rank : 54)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	148	Target Neighborhood Hits	443	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
NC score	0.050898 (rank : 55)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	148	Target Neighborhood Hits	406	Shared Neighborhood Hits	12
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

CUL2_HUMAN
NC score	0.050572 (rank : 56)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	148	Target Neighborhood Hits	36	Shared Neighborhood Hits	5
SwissProt Accessions	Q13617, O00200, Q9UNF9	Gene names	CUL2
Domain Architecture
Description	Cullin-2 (CUL-2).

CUL2_MOUSE
NC score	0.050457 (rank : 57)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	148	Target Neighborhood Hits	29	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D4H8, Q3TUR8	Gene names	Cul2
Domain Architecture
Description	Cullin-2 (CUL-2).

HECD2_MOUSE
NC score	0.050269 (rank : 58)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	148	Target Neighborhood Hits	38	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

RNF5_MOUSE
NC score	0.049828 (rank : 59)	θ value	4.03905 (rank : 95)
Query Neighborhood Hits	148	Target Neighborhood Hits	206	Shared Neighborhood Hits	20
SwissProt Accessions	O35445	Gene names	Rnf5, Ng2
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (RING finger protein 5).

RN185_HUMAN
NC score	0.046787 (rank : 60)	θ value	2.36792 (rank : 75)
Query Neighborhood Hits	148	Target Neighborhood Hits	213	Shared Neighborhood Hits	24
SwissProt Accessions	Q96GF1, Q8N900	Gene names	RNF185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

RNF5_HUMAN
NC score	0.046285 (rank : 61)	θ value	6.88961 (rank : 122)
Query Neighborhood Hits	148	Target Neighborhood Hits	206	Shared Neighborhood Hits	20
SwissProt Accessions	Q99942, Q9UMQ2	Gene names	RNF5, G16, NG2, RMA1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (HsRma1) (RING finger protein 5) (Protein G16).

RN185_MOUSE
NC score	0.045896 (rank : 62)	θ value	2.36792 (rank : 76)
Query Neighborhood Hits	148	Target Neighborhood Hits	211	Shared Neighborhood Hits	22
SwissProt Accessions	Q91YT2, Q6ZWS3	Gene names	Rnf185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

GOLI_MOUSE
NC score	0.043094 (rank : 63)	θ value	0.365318 (rank : 46)
Query Neighborhood Hits	148	Target Neighborhood Hits	134	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VEM1, Q80VL7, Q9QZQ6	Gene names	Rnf130, G1rp
Domain Architecture	No domain graphic available
Description	Goliath homolog precursor (RING finger protein 130) (G1-related zinc finger protein).

TRIM9_HUMAN
NC score	0.042449 (rank : 64)	θ value	0.62314 (rank : 49)
Query Neighborhood Hits	148	Target Neighborhood Hits	294	Shared Neighborhood Hits	11
SwissProt Accessions	Q9C026, Q92557, Q96D24, Q96NI4, Q9C025, Q9C027	Gene names	TRIM9, KIAA0282, RNF91
Domain Architecture
Description	Tripartite motif-containing protein 9 (RING finger protein 91).

NOL8_MOUSE
NC score	0.041338 (rank : 65)	θ value	0.0563607 (rank : 37)
Query Neighborhood Hits	148	Target Neighborhood Hits	210	Shared Neighborhood Hits	5
SwissProt Accessions	Q3UHX0, Q504M4, Q8CDJ7, Q9CUR0	Gene names	Nol8
Domain Architecture	No domain graphic available
Description	Nucleolar protein 8.

PDE9A_MOUSE
NC score	0.040607 (rank : 66)	θ value	0.0252991 (rank : 35)
Query Neighborhood Hits	148	Target Neighborhood Hits	72	Shared Neighborhood Hits	4
SwissProt Accessions	O70628	Gene names	Pde9a, Pde8b
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

MKRN3_HUMAN
NC score	0.039774 (rank : 67)	θ value	6.88961 (rank : 115)
Query Neighborhood Hits	148	Target Neighborhood Hits	165	Shared Neighborhood Hits	21
SwissProt Accessions	Q13064	Gene names	MKRN3, RNF63, ZNF127
Domain Architecture
Description	Makorin-3 (Zinc finger protein 127) (RING finger protein 63).

PDE9A_HUMAN
NC score	0.037135 (rank : 68)	θ value	0.0736092 (rank : 38)
Query Neighborhood Hits	148	Target Neighborhood Hits	93	Shared Neighborhood Hits	4
SwissProt Accessions	O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0	Gene names	PDE9A
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

TRIM9_MOUSE
NC score	0.036595 (rank : 69)	θ value	3.0926 (rank : 86)
Query Neighborhood Hits	148	Target Neighborhood Hits	274	Shared Neighborhood Hits	11
SwissProt Accessions	Q8C7M3, Q6ZQE5, Q80WT6, Q8C7Z4, Q8CC32, Q8CEG2, Q99PQ3	Gene names	Trim9, Kiaa0282
Domain Architecture
Description	Tripartite motif-containing protein 9.

MKRN3_MOUSE
NC score	0.036587 (rank : 70)	θ value	6.88961 (rank : 116)
Query Neighborhood Hits	148	Target Neighborhood Hits	137	Shared Neighborhood Hits	20
SwissProt Accessions	Q60764, Q7TQE4	Gene names	Mkrn3, Zfp127, Znf127
Domain Architecture
Description	Makorin-3 (Zinc finger protein 127).

MKRN4_HUMAN
NC score	0.034100 (rank : 71)	θ value	5.27518 (rank : 108)
Query Neighborhood Hits	148	Target Neighborhood Hits	147	Shared Neighborhood Hits	19
SwissProt Accessions	Q13434	Gene names	MKRN4, RNF64, ZNF127L1
Domain Architecture	No domain graphic available
Description	Makorin-4 (Zinc finger protein 127-Xp) (ZNF127-Xp) (RING finger protein 64).

MKRN1_MOUSE
NC score	0.033149 (rank : 72)	θ value	4.03905 (rank : 91)
Query Neighborhood Hits	148	Target Neighborhood Hits	141	Shared Neighborhood Hits	18
SwissProt Accessions	Q9QXP6	Gene names	Mkrn1
Domain Architecture
Description	Makorin-1.

INHA_HUMAN
NC score	0.033060 (rank : 73)	θ value	0.125558 (rank : 40)
Query Neighborhood Hits	148	Target Neighborhood Hits	66	Shared Neighborhood Hits	2
SwissProt Accessions	P05111	Gene names	INHA
Domain Architecture
Description	Inhibin alpha chain precursor.

CLUA1_HUMAN
NC score	0.032627 (rank : 74)	θ value	1.06291 (rank : 56)
Query Neighborhood Hits	148	Target Neighborhood Hits	236	Shared Neighborhood Hits	5
SwissProt Accessions	Q96AJ1, O75138, Q65ZA3, Q9H8R4, Q9H8T1	Gene names	CLUAP1, KIAA0643
Domain Architecture	No domain graphic available
Description	Clusterin-associated protein 1.

MKRN1_HUMAN
NC score	0.032506 (rank : 75)	θ value	5.27518 (rank : 107)
Query Neighborhood Hits	148	Target Neighborhood Hits	141	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UHC7, Q6GSF1, Q9H0G0, Q9UEZ7	Gene names	MKRN1, RNF61
Domain Architecture
Description	Makorin-1 (RING finger protein 61).

CLUA1_MOUSE
NC score	0.032302 (rank : 76)	θ value	1.06291 (rank : 57)
Query Neighborhood Hits	148	Target Neighborhood Hits	261	Shared Neighborhood Hits	10
SwissProt Accessions	Q8R3P7, Q6P3Y8	Gene names	Cluap1
Domain Architecture	No domain graphic available
Description	Clusterin-associated protein 1.

IPO9_HUMAN
NC score	0.027979 (rank : 77)	θ value	1.81305 (rank : 64)
Query Neighborhood Hits	148	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	Q96P70, Q8N1Y1, Q8N3I2, Q8NCG9, Q96SU6, Q9NW01, Q9P0A8, Q9ULM8	Gene names	IPO9, IMP9, KIAA1192, RANBP9
Domain Architecture
Description	Importin-9 (Imp9) (Ran-binding protein 9) (RanbP9).

IPO9_MOUSE
NC score	0.027916 (rank : 78)	θ value	1.81305 (rank : 65)
Query Neighborhood Hits	148	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q91YE6, Q924M3, Q924M4	Gene names	Ipo9, Imp9, Ranbp9
Domain Architecture
Description	Importin-9 (Importin 9a) (Imp9a) (Importin 9b) (Imp9b) (Ran-binding protein 9) (RanBP9).

RN122_HUMAN
NC score	0.026557 (rank : 79)	θ value	8.99809 (rank : 141)
Query Neighborhood Hits	148	Target Neighborhood Hits	121	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H9V4, Q52LK3	Gene names	RNF122
Domain Architecture	No domain graphic available
Description	RING finger protein 122.

PPR3D_HUMAN
NC score	0.026264 (rank : 80)	θ value	3.0926 (rank : 84)
Query Neighborhood Hits	148	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	O95685, Q6DK02	Gene names	PPP1R3D, PPP1R6
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 3D (Protein phosphatase 1, regulatory subunit 6) (Protein phosphatase 1-binding subunit R6).

RN141_HUMAN
NC score	0.025274 (rank : 81)	θ value	6.88961 (rank : 121)
Query Neighborhood Hits	148	Target Neighborhood Hits	199	Shared Neighborhood Hits	22
SwissProt Accessions	Q8WVD5, Q9NZB4	Gene names	RNF141, ZNF230
Domain Architecture	No domain graphic available
Description	RING finger protein 141 (Zinc finger protein 230).

RNF6_HUMAN
NC score	0.025148 (rank : 82)	θ value	1.81305 (rank : 68)
Query Neighborhood Hits	148	Target Neighborhood Hits	157	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y252, Q9UF41	Gene names	RNF6
Domain Architecture
Description	RING finger protein 6 (RING-H2 protein).

RN122_MOUSE
NC score	0.024303 (rank : 83)	θ value	8.99809 (rank : 142)
Query Neighborhood Hits	148	Target Neighborhood Hits	121	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BP31, Q80VA7, Q8BGD3	Gene names	Rnf122
Domain Architecture	No domain graphic available
Description	RING finger protein 122.

RN141_MOUSE
NC score	0.023941 (rank : 84)	θ value	8.99809 (rank : 143)
Query Neighborhood Hits	148	Target Neighborhood Hits	200	Shared Neighborhood Hits	22
SwissProt Accessions	Q99MB7, Q9D040, Q9D5C4, Q9D9L0	Gene names	Rnf141, Znf230
Domain Architecture	No domain graphic available
Description	RING finger protein 141 (Zinc finger protein 230).

SEC63_MOUSE
NC score	0.023253 (rank : 85)	θ value	5.27518 (rank : 111)
Query Neighborhood Hits	148	Target Neighborhood Hits	601	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VHE0, Q8VEB9	Gene names	Sec63, Sec63l
Domain Architecture
Description	Translocation protein SEC63 homolog.

YETS2_HUMAN
NC score	0.022971 (rank : 86)	θ value	0.813845 (rank : 54)
Query Neighborhood Hits	148	Target Neighborhood Hits	212	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ULM3, Q641P6, Q9NW96	Gene names	YEATS2, KIAA1197
Domain Architecture	No domain graphic available
Description	YEATS domain-containing protein 2.

SRRM2_HUMAN
NC score	0.021408 (rank : 87)	θ value	5.27518 (rank : 112)
Query Neighborhood Hits	148	Target Neighborhood Hits	1296	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

ARMC6_HUMAN
NC score	0.021050 (rank : 88)	θ value	2.36792 (rank : 71)
Query Neighborhood Hits	148	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	Q6NXE6, O94999, Q9BTH5	Gene names	ARMC6
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing protein 6.

FBN3_HUMAN
NC score	0.017827 (rank : 89)	θ value	0.163984 (rank : 43)
Query Neighborhood Hits	148	Target Neighborhood Hits	543	Shared Neighborhood Hits	20
SwissProt Accessions	Q75N90, Q75N91, Q75N92, Q75N93, Q86SJ5, Q96JP8	Gene names	FBN3, KIAA1776
Domain Architecture	No domain graphic available
Description	Fibrillin-3 precursor.

DNJC3_MOUSE
NC score	0.017502 (rank : 90)	θ value	1.38821 (rank : 61)
Query Neighborhood Hits	148	Target Neighborhood Hits	230	Shared Neighborhood Hits	5
SwissProt Accessions	Q91YW3, Q60873	Gene names	Dnajc3, P58ipk
Domain Architecture	No domain graphic available
Description	DnaJ homolog subfamily C member 3 (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor p58) (Protein kinase inhibitor of 58 kDa).

THUM1_MOUSE
NC score	0.017396 (rank : 91)	θ value	4.03905 (rank : 97)
Query Neighborhood Hits	148	Target Neighborhood Hits	55	Shared Neighborhood Hits	2
SwissProt Accessions	Q99J36, Q3U6Y3	Gene names	Thumpd1
Domain Architecture
Description	THUMP domain-containing protein 1.

PA2G3_HUMAN
NC score	0.016999 (rank : 92)	θ value	6.88961 (rank : 118)
Query Neighborhood Hits	148	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NZ20, O95768	Gene names	PLA2G3
Domain Architecture
Description	Group 3 secretory phospholipase A2 precursor (EC 3.1.1.4) (Group III secretory phospholipase A2) (Phosphatidylcholine 2-acylhydrolase GIII) (GIII sPLA2).

STX4_HUMAN
NC score	0.016402 (rank : 93)	θ value	1.06291 (rank : 58)
Query Neighborhood Hits	148	Target Neighborhood Hits	266	Shared Neighborhood Hits	7
SwissProt Accessions	Q12846, Q15525	Gene names	STX4, STX4A
Domain Architecture
Description	Syntaxin-4 (NY-REN-31 antigen).

DNJC3_HUMAN
NC score	0.016201 (rank : 94)	θ value	2.36792 (rank : 72)
Query Neighborhood Hits	148	Target Neighborhood Hits	223	Shared Neighborhood Hits	5
SwissProt Accessions	Q13217, Q86WT9, Q8N4N2	Gene names	DNAJC3, P58IPK, PRKRI
Domain Architecture	No domain graphic available
Description	DnaJ homolog subfamily C member 3 (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor p58) (Protein kinase inhibitor of 58 kDa).

KR105_HUMAN
NC score	0.015150 (rank : 95)	θ value	3.0926 (rank : 82)
Query Neighborhood Hits	148	Target Neighborhood Hits	271	Shared Neighborhood Hits	19
SwissProt Accessions	P60370, Q70LJ3	Gene names	KRTAP10-5, KAP10.5, KAP18-5, KRTAP10.5, KRTAP18-5, KRTAP18.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-5 (Keratin-associated protein 10.5) (High sulfur keratin-associated protein 10.5) (Keratin-associated protein 18-5) (Keratin-associated protein 18.5).

CF049_HUMAN
NC score	0.015092 (rank : 96)	θ value	3.0926 (rank : 81)
Query Neighborhood Hits	148	Target Neighborhood Hits	123	Shared Neighborhood Hits	4
SwissProt Accessions	Q2TBC4, Q5T3D4, Q9NSV1	Gene names	C6orf49
Domain Architecture	No domain graphic available
Description	Protein C6orf49.

STX4_MOUSE
NC score	0.014659 (rank : 97)	θ value	2.36792 (rank : 77)
Query Neighborhood Hits	148	Target Neighborhood Hits	312	Shared Neighborhood Hits	8
SwissProt Accessions	P70452	Gene names	Stx4, Stx4a
Domain Architecture
Description	Syntaxin-4.

SYP2L_MOUSE
NC score	0.014529 (rank : 98)	θ value	1.81305 (rank : 69)
Query Neighborhood Hits	148	Target Neighborhood Hits	289	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

KR104_HUMAN
NC score	0.013940 (rank : 99)	θ value	2.36792 (rank : 73)
Query Neighborhood Hits	148	Target Neighborhood Hits	313	Shared Neighborhood Hits	13
SwissProt Accessions	P60372	Gene names	KRTAP10-4, KAP10.4, KAP18-4, KRTAP10.4, KRTAP18-4, KRTAP18.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-4 (Keratin-associated protein 10.4) (High sulfur keratin-associated protein 10.4) (Keratin-associated protein 18-4) (Keratin-associated protein 18.4).

RTN2_MOUSE
NC score	0.013913 (rank : 100)	θ value	4.03905 (rank : 96)
Query Neighborhood Hits	148	Target Neighborhood Hits	48	Shared Neighborhood Hits	8
SwissProt Accessions	O70622, O70620	Gene names	Rtn2, Nspl1
Domain Architecture
Description	Reticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like protein 1) (NSPLI).

SEL1L_MOUSE
NC score	0.013683 (rank : 101)	θ value	3.0926 (rank : 85)
Query Neighborhood Hits	148	Target Neighborhood Hits	62	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z2G6, Q9DBD8	Gene names	Sel1l, Sel1h
Domain Architecture
Description	Sel-1 homolog precursor (Suppressor of lin-12-like protein) (Sel-1L).

NEST_HUMAN
NC score	0.013627 (rank : 102)	θ value	0.21417 (rank : 44)
Query Neighborhood Hits	148	Target Neighborhood Hits	1305	Shared Neighborhood Hits	20
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

ZEP1_HUMAN
NC score	0.013402 (rank : 103)	θ value	0.813845 (rank : 55)
Query Neighborhood Hits	148	Target Neighborhood Hits	1036	Shared Neighborhood Hits	12
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

TF65_MOUSE
NC score	0.013195 (rank : 104)	θ value	2.36792 (rank : 78)
Query Neighborhood Hits	148	Target Neighborhood Hits	66	Shared Neighborhood Hits	4
SwissProt Accessions	Q04207, Q62025	Gene names	Rela, Nfkb3
Domain Architecture
Description	Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit).

JIP4_HUMAN
NC score	0.013182 (rank : 105)	θ value	1.38821 (rank : 62)
Query Neighborhood Hits	148	Target Neighborhood Hits	585	Shared Neighborhood Hits	7
SwissProt Accessions	O60271, O60905, Q3KQU8, Q3MKM7, Q86WC7, Q86WC8, Q8IZX7, Q96II0, Q9H811	Gene names	SPAG9, HSS, KIAA0516, MAPK8IP4, SYD1
Domain Architecture	No domain graphic available
Description	C-jun-amino-terminal kinase-interacting protein 4 (JNK-interacting protein 4) (JIP-4) (JNK-associated leucine-zipper protein) (JLP) (Sperm-associated antigen 9) (Mitogen-activated protein kinase 8- interacting protein 4) (Human lung cancer protein 6) (HLC-6) (Proliferation-inducing protein 6) (Sperm-specific protein) (Sperm surface protein) (Protein highly expressed in testis) (PHET) (Sunday driver 1).

ABLM1_MOUSE
NC score	0.013120 (rank : 106)	θ value	5.27518 (rank : 98)
Query Neighborhood Hits	148	Target Neighborhood Hits	356	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K4G5, Q80U86, Q8BIR9, Q8K4G3, Q8K4G4	Gene names	Ablim1, Ablim, Kiaa0059
Domain Architecture	No domain graphic available
Description	Actin-binding LIM protein 1 (Actin-binding LIM protein family member 1) (abLIM-1).

ELL3_MOUSE
NC score	0.013053 (rank : 107)	θ value	5.27518 (rank : 102)
Query Neighborhood Hits	148	Target Neighborhood Hits	47	Shared Neighborhood Hits	3
SwissProt Accessions	Q80VR2	Gene names	Ell3
Domain Architecture
Description	RNA polymerase II elongation factor ELL3.

PYGO1_MOUSE
NC score	0.013007 (rank : 108)	θ value	5.27518 (rank : 110)
Query Neighborhood Hits	148	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D0P5	Gene names	Pygo1
Domain Architecture
Description	Pygopus homolog 1.

NBN_MOUSE
NC score	0.012802 (rank : 109)	θ value	5.27518 (rank : 109)
Query Neighborhood Hits	148	Target Neighborhood Hits	125	Shared Neighborhood Hits	5
SwissProt Accessions	Q9R207, O88981, Q3UY57, Q811I6, Q8CCY0, Q9R1X1	Gene names	Nbn, Nbs1
Domain Architecture	No domain graphic available
Description	Nibrin (Nijmegen breakage syndrome protein 1 homolog) (Cell cycle regulatory protein p95).

KRA24_HUMAN
NC score	0.012794 (rank : 110)	θ value	8.99809 (rank : 133)
Query Neighborhood Hits	148	Target Neighborhood Hits	192	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BYR9, Q495J2	Gene names	KRTAP2-4, KAP2.4, KRTAP2.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 2-4 (Keratin-associated protein 2.4) (High sulfur keratin-associated protein 2.4).

IWS1_HUMAN
NC score	0.012782 (rank : 111)	θ value	5.27518 (rank : 105)
Query Neighborhood Hits	148	Target Neighborhood Hits	1241	Shared Neighborhood Hits	23
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

OST3B_MOUSE
NC score	0.012538 (rank : 112)	θ value	0.813845 (rank : 51)
Query Neighborhood Hits	148	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QZS6	Gene names	Hs3st3b1, 3ost3b1, Hs3st3b
Domain Architecture	No domain graphic available
Description	Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 (EC 2.8.2.30) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1) (Heparan sulfate 3-O-sulfotransferase 3B1) (m3-OST-3B).

EST1A_MOUSE
NC score	0.012267 (rank : 113)	θ value	5.27518 (rank : 103)
Query Neighborhood Hits	148	Target Neighborhood Hits	138	Shared Neighborhood Hits	4
SwissProt Accessions	P61406, Q5NC64	Gene names	Est1a, Kiaa0732
Domain Architecture
Description	Telomerase-binding protein EST1A (Ever shorter telomeres 1A) (Telomerase subunit EST1A) (EST1-like protein A).

ADA18_MOUSE
NC score	0.011975 (rank : 114)	θ value	1.38821 (rank : 59)
Query Neighborhood Hits	148	Target Neighborhood Hits	227	Shared Neighborhood Hits	15
SwissProt Accessions	Q9R157, Q60621	Gene names	Adam18, Adam27, Dtgn3, Tmdc3
Domain Architecture
Description	ADAM 18 precursor (A disintegrin and metalloproteinase domain 18) (Transmembrane metalloproteinase-like, disintegrin-like, and cysteine- rich protein III) (tMDC III) (ADAM 27).

ASPH_HUMAN
NC score	0.011841 (rank : 115)	θ value	8.99809 (rank : 125)
Query Neighborhood Hits	148	Target Neighborhood Hits	158	Shared Neighborhood Hits	5
SwissProt Accessions	Q12797	Gene names	ASPH
Domain Architecture
Description	Aspartyl/asparaginyl beta-hydroxylase (EC 1.14.11.16) (Aspartate beta- hydroxylase) (ASP beta-hydroxylase) (Peptide-aspartate beta- dioxygenase).

WIF1_MOUSE
NC score	0.011372 (rank : 116)	θ value	2.36792 (rank : 79)
Query Neighborhood Hits	148	Target Neighborhood Hits	393	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WUA1	Gene names	Wif1
Domain Architecture
Description	Wnt inhibitory factor 1 precursor (WIF-1).

KRA58_HUMAN
NC score	0.011358 (rank : 117)	θ value	4.03905 (rank : 90)
Query Neighborhood Hits	148	Target Neighborhood Hits	324	Shared Neighborhood Hits	13
SwissProt Accessions	O75690, Q6L8G7, Q6UTX6	Gene names	KRTAP5-8, KAP5.8, KRTAP5.8, UHSKB
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-8 (Keratin-associated protein 5.8) (Ultrahigh sulfur keratin-associated protein 5.8) (Keratin, ultra high-sulfur matrix protein B) (UHS keratin B) (UHS KerB).

KRA56_HUMAN
NC score	0.011282 (rank : 118)	θ value	8.99809 (rank : 136)
Query Neighborhood Hits	148	Target Neighborhood Hits	207	Shared Neighborhood Hits	10
SwissProt Accessions	Q6L8G9	Gene names	KRTAP5-6, KAP5.6, KRTAP5.6
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-6 (Keratin-associated protein 5.6) (Ultrahigh sulfur keratin-associated protein 5.6).

NC6IP_HUMAN
NC score	0.011169 (rank : 119)	θ value	6.88961 (rank : 117)
Query Neighborhood Hits	148	Target Neighborhood Hits	116	Shared Neighborhood Hits	5
SwissProt Accessions	Q96RS0, Q5GH23, Q8TDG9, Q96QU3, Q9H5V3	Gene names	NCOA6IP, PIMT
Domain Architecture	No domain graphic available
Description	Putative RNA methyltransferase NCOA6IP (EC 2.1.1.-) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIPMT) (PIMT) (CLL-associated antigen KW-2) (Hepatocellular carcinoma-associated antigen 137) (HCA137).

AAKG3_MOUSE
NC score	0.011004 (rank : 120)	θ value	4.03905 (rank : 87)
Query Neighborhood Hits	148	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BGM7, Q80WK8, Q8CJ41	Gene names	Prkag3
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase subunit gamma-3 (AMPK gamma-3 chain) (AMPK gamma3).

B3A4_HUMAN
NC score	0.010983 (rank : 121)	θ value	1.38821 (rank : 60)
Query Neighborhood Hits	148	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	Q96Q91, Q96RM5, Q9BXF2, Q9BXN3	Gene names	SLC4A9, AE4, SBC5
Domain Architecture
Description	Anion exchange protein 4 (Anion exchanger 4) (Solute carrier family 4 member 9) (Sodium bicarbonate cotransporter 5).

APLP1_MOUSE
NC score	0.010390 (rank : 122)	θ value	5.27518 (rank : 100)
Query Neighborhood Hits	148	Target Neighborhood Hits	130	Shared Neighborhood Hits	4
SwissProt Accessions	Q03157, Q8VC38	Gene names	Aplp1
Domain Architecture
Description	Amyloid-like protein 1 precursor (APLP) (APLP-1) [Contains: C30].

NOTC1_MOUSE
NC score	0.010157 (rank : 123)	θ value	8.99809 (rank : 139)
Query Neighborhood Hits	148	Target Neighborhood Hits	916	Shared Neighborhood Hits	23
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

EGFL7_HUMAN
NC score	0.010156 (rank : 124)	θ value	5.27518 (rank : 101)
Query Neighborhood Hits	148	Target Neighborhood Hits	325	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UHF1, Q5M7Y5, Q5VUD5, Q96EG0	Gene names	EGFL7, MEGF7
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 7 precursor (Multiple EGF-like domain protein 7) (Multiple epidermal growth factor-like domain protein 7) (Vascular endothelial statin) (VE-statin) (NOTCH4-like protein) (ZNEU1).

PCSK5_HUMAN
NC score	0.009853 (rank : 125)	θ value	1.38821 (rank : 63)
Query Neighborhood Hits	148	Target Neighborhood Hits	291	Shared Neighborhood Hits	10
SwissProt Accessions	Q92824, Q13527	Gene names	PCSK5, PC5, PC6
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (hPC6).

CF182_MOUSE
NC score	0.009647 (rank : 126)	θ value	4.03905 (rank : 89)
Query Neighborhood Hits	148	Target Neighborhood Hits	551	Shared Neighborhood Hits	9
SwissProt Accessions	Q8VDS7, Q9CZE0, Q9D5A1	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf182 homolog.

FAS_MOUSE
NC score	0.009548 (rank : 127)	θ value	5.27518 (rank : 104)
Query Neighborhood Hits	148	Target Neighborhood Hits	76	Shared Neighborhood Hits	2
SwissProt Accessions	P19096, Q6PB72, Q8C4Z0, Q9EQR0	Gene names	Fasn
Domain Architecture	No domain graphic available
Description	Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S- acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S- malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.10); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)].

MICA2_HUMAN
NC score	0.009456 (rank : 128)	θ value	1.81305 (rank : 66)
Query Neighborhood Hits	148	Target Neighborhood Hits	174	Shared Neighborhood Hits	2
SwissProt Accessions	O94851, Q7Z3A8	Gene names	MICAL2, KIAA0750
Domain Architecture
Description	Protein MICAL-2.

ADDB_MOUSE
NC score	0.009120 (rank : 129)	θ value	3.0926 (rank : 80)
Query Neighborhood Hits	148	Target Neighborhood Hits	574	Shared Neighborhood Hits	7
SwissProt Accessions	Q9QYB8, Q3U0E1, Q80VH9, Q8C1C4, Q9CXE3, Q9JLE5, Q9QYB7	Gene names	Add2
Domain Architecture
Description	Beta-adducin (Erythrocyte adducin subunit beta) (Add97).

ARHGC_MOUSE
NC score	0.008537 (rank : 130)	θ value	2.36792 (rank : 70)
Query Neighborhood Hits	148	Target Neighborhood Hits	344	Shared Neighborhood Hits	8
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

FBN1_HUMAN
NC score	0.008497 (rank : 131)	θ value	8.99809 (rank : 130)
Query Neighborhood Hits	148	Target Neighborhood Hits	557	Shared Neighborhood Hits	21
SwissProt Accessions	P35555, Q15972, Q75N87	Gene names	FBN1, FBN
Domain Architecture
Description	Fibrillin-1 precursor.

KRA51_HUMAN
NC score	0.008250 (rank : 132)	θ value	8.99809 (rank : 134)
Query Neighborhood Hits	148	Target Neighborhood Hits	288	Shared Neighborhood Hits	12
SwissProt Accessions	Q6L8H4	Gene names	KRTAP5-1, KAP5.1, KRTAP5.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-1 (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1).

PLCB3_HUMAN
NC score	0.008062 (rank : 133)	θ value	4.03905 (rank : 92)
Query Neighborhood Hits	148	Target Neighborhood Hits	445	Shared Neighborhood Hits	9
SwissProt Accessions	Q01970	Gene names	PLCB3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

KRA53_HUMAN
NC score	0.008016 (rank : 134)	θ value	8.99809 (rank : 135)
Query Neighborhood Hits	148	Target Neighborhood Hits	331	Shared Neighborhood Hits	14
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

AGRIN_HUMAN
NC score	0.007839 (rank : 135)	θ value	5.27518 (rank : 99)
Query Neighborhood Hits	148	Target Neighborhood Hits	582	Shared Neighborhood Hits	19
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

CT077_HUMAN
NC score	0.007703 (rank : 136)	θ value	8.99809 (rank : 129)
Query Neighborhood Hits	148	Target Neighborhood Hits	155	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NQG5	Gene names	C20orf77
Domain Architecture
Description	Uncharacterized protein C20orf77.

RGS12_HUMAN
NC score	0.007697 (rank : 137)	θ value	4.03905 (rank : 94)
Query Neighborhood Hits	148	Target Neighborhood Hits	333	Shared Neighborhood Hits	5
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

NIPBL_HUMAN
NC score	0.007552 (rank : 138)	θ value	3.0926 (rank : 83)
Query Neighborhood Hits	148	Target Neighborhood Hits	1311	Shared Neighborhood Hits	21
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

PEX6_MOUSE
NC score	0.007363 (rank : 139)	θ value	2.36792 (rank : 74)
Query Neighborhood Hits	148	Target Neighborhood Hits	94	Shared Neighborhood Hits	2
SwissProt Accessions	Q99LC9, Q6YNQ9	Gene names	Pex6
Domain Architecture	No domain graphic available
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).

NOTC1_HUMAN
NC score	0.006819 (rank : 140)	θ value	8.99809 (rank : 138)
Query Neighborhood Hits	148	Target Neighborhood Hits	906	Shared Neighborhood Hits	24
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

PLXA4_HUMAN
NC score	0.006802 (rank : 141)	θ value	4.03905 (rank : 93)
Query Neighborhood Hits	148	Target Neighborhood Hits	106	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCM2, Q6UWC6, Q6ZW89, Q8N969, Q8ND00, Q8NEN3, Q9NTD4	Gene names	PLXNA4, KIAA1550, PLXNA4A, PLXNA4B
Domain Architecture	No domain graphic available
Description	Plexin-A4 precursor.

NUMA1_HUMAN
NC score	0.006540 (rank : 142)	θ value	0.62314 (rank : 48)
Query Neighborhood Hits	148	Target Neighborhood Hits	1523	Shared Neighborhood Hits	21
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

PI4KB_MOUSE
NC score	0.005487 (rank : 143)	θ value	8.99809 (rank : 140)
Query Neighborhood Hits	148	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

SON_MOUSE
NC score	0.005418 (rank : 144)	θ value	6.88961 (rank : 123)
Query Neighborhood Hits	148	Target Neighborhood Hits	957	Shared Neighborhood Hits	16
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

BRD8_HUMAN
NC score	0.005386 (rank : 145)	θ value	8.99809 (rank : 126)
Query Neighborhood Hits	148	Target Neighborhood Hits	292	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H0E9, O43178, Q15355, Q59GN0, Q969M9	Gene names	BRD8, SMAP
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8 (p120) (Skeletal muscle abundant protein) (Thyroid hormone receptor coactivating protein 120kDa) (TrCP120).

MAGD2_HUMAN
NC score	0.005038 (rank : 146)	θ value	5.27518 (rank : 106)
Query Neighborhood Hits	148	Target Neighborhood Hits	95	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UNF1, O76058, Q5BJF3, Q8NAL6, Q9H218, Q9P0U9, Q9UM52	Gene names	MAGED2, BCG1
Domain Architecture
Description	Melanoma-associated antigen D2 (MAGE-D2 antigen) (MAGE-D) (Breast cancer-associated gene 1 protein) (BCG-1) (11B6) (Hepatocellular carcinoma-associated protein JCL-1).

ATS13_MOUSE
NC score	0.004566 (rank : 147)	θ value	4.03905 (rank : 88)
Query Neighborhood Hits	148	Target Neighborhood Hits	227	Shared Neighborhood Hits	6
SwissProt Accessions	Q769J6, Q76LW1	Gene names	Adamts13
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

SYT14_MOUSE
NC score	0.004446 (rank : 148)	θ value	8.99809 (rank : 145)
Query Neighborhood Hits	148	Target Neighborhood Hits	82	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TN84	Gene names	Syt14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

PACN3_HUMAN
NC score	0.004217 (rank : 149)	θ value	6.88961 (rank : 119)
Query Neighborhood Hits	148	Target Neighborhood Hits	385	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

NFKB1_HUMAN
NC score	0.003824 (rank : 150)	θ value	8.99809 (rank : 137)
Query Neighborhood Hits	148	Target Neighborhood Hits	306	Shared Neighborhood Hits	6
SwissProt Accessions	P19838, Q68D84, Q86V43, Q8N4X7, Q9NZC0	Gene names	NFKB1
Domain Architecture
Description	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) [Contains: Nuclear factor NF-kappa-B p50 subunit].

STA13_MOUSE
NC score	0.003766 (rank : 151)	θ value	8.99809 (rank : 144)
Query Neighborhood Hits	148	Target Neighborhood Hits	89	Shared Neighborhood Hits	3
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

TGON2_HUMAN
NC score	0.002980 (rank : 152)	θ value	8.99809 (rank : 146)
Query Neighborhood Hits	148	Target Neighborhood Hits	1037	Shared Neighborhood Hits	15
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

PTN23_HUMAN
NC score	0.002710 (rank : 153)	θ value	6.88961 (rank : 120)
Query Neighborhood Hits	148	Target Neighborhood Hits	646	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

CO7A1_HUMAN
NC score	0.002471 (rank : 154)	θ value	8.99809 (rank : 128)
Query Neighborhood Hits	148	Target Neighborhood Hits	807	Shared Neighborhood Hits	8
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

RAI14_HUMAN
NC score	0.002397 (rank : 155)	θ value	1.81305 (rank : 67)
Query Neighborhood Hits	148	Target Neighborhood Hits	1367	Shared Neighborhood Hits	16
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

CELR1_HUMAN
NC score	0.000347 (rank : 156)	θ value	8.99809 (rank : 127)
Query Neighborhood Hits	148	Target Neighborhood Hits	613	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NYQ6, O95722, Q5TH47, Q9BWQ5, Q9Y506, Q9Y526	Gene names	CELSR1, CDHF9, FMI2
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 1 precursor (Flamingo homolog 2) (hFmi2).

TMPS6_MOUSE
NC score	0.000107 (rank : 157)	θ value	6.88961 (rank : 124)
Query Neighborhood Hits	148	Target Neighborhood Hits	341	Shared Neighborhood Hits	7
SwissProt Accessions	Q9DBI0, Q6PF94	Gene names	Tmprss6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

GCC2_MOUSE
NC score	0.000102 (rank : 158)	θ value	8.99809 (rank : 131)
Query Neighborhood Hits	148	Target Neighborhood Hits	1619	Shared Neighborhood Hits	16
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

TAOK3_MOUSE
NC score	-0.001888 (rank : 159)	θ value	5.27518 (rank : 114)
Query Neighborhood Hits	148	Target Neighborhood Hits	1458	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

TAOK3_HUMAN
NC score	-0.002035 (rank : 160)	θ value	5.27518 (rank : 113)
Query Neighborhood Hits	148	Target Neighborhood Hits	1494	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

IGF1R_HUMAN
NC score	-0.002797 (rank : 161)	θ value	8.99809 (rank : 132)
Query Neighborhood Hits	148	Target Neighborhood Hits	977	Shared Neighborhood Hits	12
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

ZBT40_HUMAN
NC score	-0.003790 (rank : 162)	θ value	8.99809 (rank : 147)
Query Neighborhood Hits	148	Target Neighborhood Hits	949	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NUA8, O75066, Q5TFU5, Q8N1R1	Gene names	ZBTB40, KIAA0478
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 40.

ZN425_HUMAN
NC score	-0.003975 (rank : 163)	θ value	8.99809 (rank : 148)
Query Neighborhood Hits	148	Target Neighborhood Hits	795	Shared Neighborhood Hits	5
SwissProt Accessions	Q6IV72	Gene names	ZNF425
Domain Architecture	No domain graphic available
Description	Zinc finger protein 425.