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Network neighborhood for query Sequence : EDD1_MOUSE

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EDD1_MOUSE
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

EDD1_HUMAN
θ value	0 (rank : 1)	NC score	0.996449 (rank : 2)
Query Neighborhood Hits	167	Target Neighborhood Hits	170	Shared Neighborhood Hits	135
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

EDD1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	167	Target Neighborhood Hits	167	Shared Neighborhood Hits	167
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

HUWE1_HUMAN
θ value	1.62847e-25 (rank : 3)	NC score	0.699896 (rank : 10)
Query Neighborhood Hits	167	Target Neighborhood Hits	443	Shared Neighborhood Hits	56
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	1.62847e-25 (rank : 4)	NC score	0.700234 (rank : 9)
Query Neighborhood Hits	167	Target Neighborhood Hits	406	Shared Neighborhood Hits	54
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

K0317_MOUSE
θ value	1.37858e-24 (rank : 5)	NC score	0.734037 (rank : 3)
Query Neighborhood Hits	167	Target Neighborhood Hits	43	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_HUMAN
θ value	5.23862e-24 (rank : 6)	NC score	0.732745 (rank : 4)
Query Neighborhood Hits	167	Target Neighborhood Hits	46	Shared Neighborhood Hits	34
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

SMUF1_HUMAN
θ value	2.20094e-22 (rank : 7)	NC score	0.689678 (rank : 11)
Query Neighborhood Hits	167	Target Neighborhood Hits	135	Shared Neighborhood Hits	33
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
θ value	2.20094e-22 (rank : 8)	NC score	0.687207 (rank : 12)
Query Neighborhood Hits	167	Target Neighborhood Hits	142	Shared Neighborhood Hits	33
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SMUF2_HUMAN
θ value	8.36355e-22 (rank : 9)	NC score	0.684324 (rank : 13)
Query Neighborhood Hits	167	Target Neighborhood Hits	142	Shared Neighborhood Hits	34
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

NED4L_HUMAN
θ value	4.15078e-21 (rank : 10)	NC score	0.626426 (rank : 28)
Query Neighborhood Hits	167	Target Neighborhood Hits	238	Shared Neighborhood Hits	36
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
θ value	4.15078e-21 (rank : 11)	NC score	0.627251 (rank : 27)
Query Neighborhood Hits	167	Target Neighborhood Hits	231	Shared Neighborhood Hits	36
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

UBE3A_MOUSE
θ value	2.69047e-20 (rank : 12)	NC score	0.705426 (rank : 5)
Query Neighborhood Hits	167	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

ITCH_MOUSE
θ value	4.58923e-20 (rank : 13)	NC score	0.671252 (rank : 15)
Query Neighborhood Hits	167	Target Neighborhood Hits	127	Shared Neighborhood Hits	34
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

ITCH_HUMAN
θ value	7.82807e-20 (rank : 14)	NC score	0.665051 (rank : 17)
Query Neighborhood Hits	167	Target Neighborhood Hits	162	Shared Neighborhood Hits	35
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

NEDD4_HUMAN
θ value	7.82807e-20 (rank : 15)	NC score	0.635845 (rank : 26)
Query Neighborhood Hits	167	Target Neighborhood Hits	214	Shared Neighborhood Hits	34
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

NEDD4_MOUSE
θ value	2.27762e-19 (rank : 16)	NC score	0.640137 (rank : 25)
Query Neighborhood Hits	167	Target Neighborhood Hits	212	Shared Neighborhood Hits	34
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

UBE3A_HUMAN
θ value	3.28887e-18 (rank : 17)	NC score	0.702195 (rank : 7)
Query Neighborhood Hits	167	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3C_HUMAN
θ value	9.56915e-18 (rank : 18)	NC score	0.703674 (rank : 6)
Query Neighborhood Hits	167	Target Neighborhood Hits	51	Shared Neighborhood Hits	33
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
θ value	4.74913e-17 (rank : 19)	NC score	0.701260 (rank : 8)
Query Neighborhood Hits	167	Target Neighborhood Hits	48	Shared Neighborhood Hits	33
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

HERC2_MOUSE
θ value	5.25075e-16 (rank : 20)	NC score	0.537684 (rank : 31)
Query Neighborhood Hits	167	Target Neighborhood Hits	167	Shared Neighborhood Hits	41
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_HUMAN
θ value	8.95645e-16 (rank : 21)	NC score	0.534297 (rank : 32)
Query Neighborhood Hits	167	Target Neighborhood Hits	163	Shared Neighborhood Hits	41
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HECD3_MOUSE
θ value	1.52774e-15 (rank : 22)	NC score	0.643348 (rank : 23)
Query Neighborhood Hits	167	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_HUMAN
θ value	2.60593e-15 (rank : 23)	NC score	0.641138 (rank : 24)
Query Neighborhood Hits	167	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

WWP2_MOUSE
θ value	9.90251e-15 (rank : 24)	NC score	0.654237 (rank : 18)
Query Neighborhood Hits	167	Target Neighborhood Hits	118	Shared Neighborhood Hits	36
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

WWP2_HUMAN
θ value	2.20605e-14 (rank : 25)	NC score	0.652745 (rank : 19)
Query Neighborhood Hits	167	Target Neighborhood Hits	177	Shared Neighborhood Hits	41
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP1_HUMAN
θ value	1.09485e-13 (rank : 26)	NC score	0.645148 (rank : 22)
Query Neighborhood Hits	167	Target Neighborhood Hits	262	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

WWP1_MOUSE
θ value	1.09485e-13 (rank : 27)	NC score	0.649368 (rank : 20)
Query Neighborhood Hits	167	Target Neighborhood Hits	138	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

TRIPC_HUMAN
θ value	1.86753e-13 (rank : 28)	NC score	0.646610 (rank : 21)
Query Neighborhood Hits	167	Target Neighborhood Hits	319	Shared Neighborhood Hits	44
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

PABP3_HUMAN
θ value	2.69671e-12 (rank : 29)	NC score	0.171199 (rank : 38)
Query Neighborhood Hits	167	Target Neighborhood Hits	259	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H361, Q8NHV0, Q9H086	Gene names	PABPC3, PABP3, PABPL3
Domain Architecture
Description	Polyadenylate-binding protein 3 (Poly(A)-binding protein 3) (PABP 3) (Testis-specific poly(A)-binding protein).

HECD2_MOUSE
θ value	4.59992e-12 (rank : 30)	NC score	0.676192 (rank : 14)
Query Neighborhood Hits	167	Target Neighborhood Hits	38	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

PABP1_MOUSE
θ value	3.89403e-11 (rank : 31)	NC score	0.163426 (rank : 40)
Query Neighborhood Hits	167	Target Neighborhood Hits	278	Shared Neighborhood Hits	8
SwissProt Accessions	P29341	Gene names	Pabpc1, Pabp1
Domain Architecture
Description	Polyadenylate-binding protein 1 (Poly(A)-binding protein 1) (PABP 1).

HECD1_HUMAN
θ value	5.08577e-11 (rank : 32)	NC score	0.461428 (rank : 33)
Query Neighborhood Hits	167	Target Neighborhood Hits	371	Shared Neighborhood Hits	34
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

PABP1_HUMAN
θ value	5.08577e-11 (rank : 33)	NC score	0.163446 (rank : 39)
Query Neighborhood Hits	167	Target Neighborhood Hits	269	Shared Neighborhood Hits	8
SwissProt Accessions	P11940, Q15097, Q93004	Gene names	PABPC1, PAB1, PABP1, PABPC2
Domain Architecture
Description	Polyadenylate-binding protein 1 (Poly(A)-binding protein 1) (PABP 1).

HECD2_HUMAN
θ value	6.64225e-11 (rank : 34)	NC score	0.670006 (rank : 16)
Query Neighborhood Hits	167	Target Neighborhood Hits	41	Shared Neighborhood Hits	33
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HERC3_HUMAN
θ value	2.13673e-09 (rank : 35)	NC score	0.561811 (rank : 29)
Query Neighborhood Hits	167	Target Neighborhood Hits	62	Shared Neighborhood Hits	39
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

PABP4_HUMAN
θ value	2.13673e-09 (rank : 36)	NC score	0.154581 (rank : 43)
Query Neighborhood Hits	167	Target Neighborhood Hits	268	Shared Neighborhood Hits	8
SwissProt Accessions	Q13310, Q6P0N3	Gene names	PABPC4, APP1, PABP4
Domain Architecture
Description	Polyadenylate-binding protein 4 (Poly(A)-binding protein 4) (PABP 4) (Inducible poly(A)-binding protein) (iPABP) (Activated-platelet protein 1) (APP-1).

HERC5_HUMAN
θ value	0.00020696 (rank : 37)	NC score	0.541591 (rank : 30)
Query Neighborhood Hits	167	Target Neighborhood Hits	66	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

FBX11_HUMAN
θ value	0.00228821 (rank : 38)	NC score	0.110166 (rank : 54)
Query Neighborhood Hits	167	Target Neighborhood Hits	72	Shared Neighborhood Hits	3
SwissProt Accessions	Q86XK2, Q8IXG3, Q96E90, Q9H6V8, Q9H9L1, Q9NR14, Q9UFK1, Q9UHI1, Q9UKC2	Gene names	FBXO11, FBX11, VIT1
Domain Architecture
Description	F-box only protein 11 (Vitiligo-associated protein VIT-1).

AKA12_HUMAN
θ value	0.0193708 (rank : 39)	NC score	0.088207 (rank : 67)
Query Neighborhood Hits	167	Target Neighborhood Hits	825	Shared Neighborhood Hits	36
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

LEO1_HUMAN
θ value	0.0193708 (rank : 40)	NC score	0.072471 (rank : 79)
Query Neighborhood Hits	167	Target Neighborhood Hits	958	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

NFH_HUMAN
θ value	0.0193708 (rank : 41)	NC score	0.025651 (rank : 138)
Query Neighborhood Hits	167	Target Neighborhood Hits	1242	Shared Neighborhood Hits	40
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

UBQL4_MOUSE
θ value	0.0193708 (rank : 42)	NC score	0.048311 (rank : 109)
Query Neighborhood Hits	167	Target Neighborhood Hits	99	Shared Neighborhood Hits	4
SwissProt Accessions	Q99NB8, Q8BP88	Gene names	Ubqln4, Ubin
Domain Architecture
Description	Ubiquilin-4 (Ataxin-1 ubiquitin-like-interacting protein A1U).

LEO1_MOUSE
θ value	0.0330416 (rank : 43)	NC score	0.064855 (rank : 86)
Query Neighborhood Hits	167	Target Neighborhood Hits	946	Shared Neighborhood Hits	29
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

BSCL2_HUMAN
θ value	0.0563607 (rank : 44)	NC score	0.109119 (rank : 55)
Query Neighborhood Hits	167	Target Neighborhood Hits	148	Shared Neighborhood Hits	12
SwissProt Accessions	Q96G97, Q96SV1, Q9BSQ0	Gene names	BSCL2
Domain Architecture	No domain graphic available
Description	Seipin (Bernardinelli-Seip congenital lipodystrophy type 2 protein).

ACCN4_HUMAN
θ value	0.0736092 (rank : 45)	NC score	0.029346 (rank : 126)
Query Neighborhood Hits	167	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q96FT7, Q53SB7, Q6GMS1, Q6PIN9, Q9NQA4	Gene names	ACCN4, ASIC4
Domain Architecture	No domain graphic available
Description	Amiloride-sensitive cation channel 4 (Amiloride-sensitive cation channel 4, pituitary) (Acid-sensing ion channel 4).

ENAH_MOUSE
θ value	0.0736092 (rank : 46)	NC score	0.037228 (rank : 116)
Query Neighborhood Hits	167	Target Neighborhood Hits	919	Shared Neighborhood Hits	22
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

GNAS1_MOUSE
θ value	0.163984 (rank : 47)	NC score	0.025439 (rank : 142)
Query Neighborhood Hits	167	Target Neighborhood Hits	651	Shared Neighborhood Hits	30
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

JHD2B_HUMAN
θ value	0.163984 (rank : 48)	NC score	0.036452 (rank : 119)
Query Neighborhood Hits	167	Target Neighborhood Hits	171	Shared Neighborhood Hits	8
SwissProt Accessions	Q7LBC6, Q9BVH6, Q9BW93, Q9BZ52, Q9NYF4, Q9UPS0	Gene names	JMJD1B, C5orf7, JHDM2B, KIAA1082
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2B (EC 1.14.11.-) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA).

PEG3_MOUSE
θ value	0.163984 (rank : 49)	NC score	0.011216 (rank : 181)
Query Neighborhood Hits	167	Target Neighborhood Hits	1101	Shared Neighborhood Hits	27
SwissProt Accessions	Q3URU2, O54978, Q3TQ69, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53	Gene names	Peg3, Kiaa0287, Pw1
Domain Architecture	No domain graphic available
Description	Paternally expressed gene 3 protein (ASF-1).

HXB4_MOUSE
θ value	0.279714 (rank : 50)	NC score	0.013431 (rank : 173)
Query Neighborhood Hits	167	Target Neighborhood Hits	375	Shared Neighborhood Hits	4
SwissProt Accessions	P10284, Q3UZB4, Q4VBG0	Gene names	Hoxb4, Hox-2.6, Hoxb-4
Domain Architecture
Description	Homeobox protein Hox-B4 (Hox-2.6).

NSBP1_MOUSE
θ value	0.279714 (rank : 51)	NC score	0.064520 (rank : 87)
Query Neighborhood Hits	167	Target Neighborhood Hits	681	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JL35, O88832, Q8VC71, Q9CUW1	Gene names	Nsbp1, Garp45
Domain Architecture	No domain graphic available
Description	Nucleosome-binding protein 1 (Nucleosome-binding protein 45) (NBP-45) (GARP45 protein).

PGCA_HUMAN
θ value	0.279714 (rank : 52)	NC score	0.023547 (rank : 148)
Query Neighborhood Hits	167	Target Neighborhood Hits	821	Shared Neighborhood Hits	19
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

CGRE1_MOUSE
θ value	0.365318 (rank : 53)	NC score	0.066077 (rank : 83)
Query Neighborhood Hits	167	Target Neighborhood Hits	173	Shared Neighborhood Hits	8
SwissProt Accessions	Q8R1U2, Q9D1K1	Gene names	Cgref1, Cgr11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

DMRTC_HUMAN
θ value	0.365318 (rank : 54)	NC score	0.070761 (rank : 80)
Query Neighborhood Hits	167	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q5HYR2, Q5HYR0, Q5U5K2, Q8N6L3, Q96SD3	Gene names	DMRTC1
Domain Architecture	No domain graphic available
Description	Doublesex- and mab-3-related transcription factor C1.

VPS72_MOUSE
θ value	0.365318 (rank : 55)	NC score	0.073531 (rank : 78)
Query Neighborhood Hits	167	Target Neighborhood Hits	286	Shared Neighborhood Hits	14
SwissProt Accessions	Q62481, Q3U2N4, Q810A9, Q99K81	Gene names	Vps72, Tcfl1, Yl1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

RCBT2_MOUSE
θ value	0.47712 (rank : 56)	NC score	0.089008 (rank : 66)
Query Neighborhood Hits	167	Target Neighborhood Hits	156	Shared Neighborhood Hits	12
SwissProt Accessions	Q99LJ7, Q3TUA3, Q8BMG2	Gene names	Rcbtb2, Chc1l
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like).

WDHD1_MOUSE
θ value	0.47712 (rank : 57)	NC score	0.026394 (rank : 135)
Query Neighborhood Hits	167	Target Neighborhood Hits	414	Shared Neighborhood Hits	11
SwissProt Accessions	P59328, Q6P408	Gene names	Wdhd1, And1
Domain Architecture	No domain graphic available
Description	WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA- binding protein 1) (And-1).

ADA28_HUMAN
θ value	0.62314 (rank : 58)	NC score	0.013821 (rank : 170)
Query Neighborhood Hits	167	Target Neighborhood Hits	244	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UKQ2, Q9Y339, Q9Y3S0	Gene names	ADAM28, MDCL
Domain Architecture
Description	ADAM 28 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 28) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein-L) (MDC-L) (eMDC II) (ADAM23).

RCBT2_HUMAN
θ value	0.62314 (rank : 59)	NC score	0.087467 (rank : 68)
Query Neighborhood Hits	167	Target Neighborhood Hits	158	Shared Neighborhood Hits	12
SwissProt Accessions	O95199	Gene names	RCBTB2, CHC1L, RLG
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like) (CHC1-L) (RCC1-like G exchanging factor).

TNC6B_HUMAN
θ value	0.62314 (rank : 60)	NC score	0.047174 (rank : 110)
Query Neighborhood Hits	167	Target Neighborhood Hits	256	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UPQ9, Q5TH52, Q8TBX2	Gene names	TNRC6B, KIAA1093
Domain Architecture
Description	Trinucleotide repeat-containing 6B protein.

LYRIC_MOUSE
θ value	0.813845 (rank : 61)	NC score	0.052657 (rank : 104)
Query Neighborhood Hits	167	Target Neighborhood Hits	126	Shared Neighborhood Hits	13
SwissProt Accessions	Q80WJ7, Q3U9F8, Q3UAQ8, Q8BN67, Q8CBT9, Q8CDL0, Q8CGI7, Q9D052	Gene names	Mtdh, Lyric
Domain Architecture	No domain graphic available
Description	Protein LYRIC (Lysine-rich CEACAM1 co-isolated protein) (3D3/LYRIC) (Metastasis adhesion protein) (Metadherin).

WRN_MOUSE
θ value	0.813845 (rank : 62)	NC score	0.026801 (rank : 134)
Query Neighborhood Hits	167	Target Neighborhood Hits	295	Shared Neighborhood Hits	7
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

MUC7_HUMAN
θ value	1.06291 (rank : 63)	NC score	0.037392 (rank : 115)
Query Neighborhood Hits	167	Target Neighborhood Hits	538	Shared Neighborhood Hits	21
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

PGCA_MOUSE
θ value	1.06291 (rank : 64)	NC score	0.021556 (rank : 150)
Query Neighborhood Hits	167	Target Neighborhood Hits	643	Shared Neighborhood Hits	22
SwissProt Accessions	Q61282, Q64021	Gene names	Agc1, Agc
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP).

SRGEF_HUMAN
θ value	1.06291 (rank : 65)	NC score	0.111868 (rank : 53)
Query Neighborhood Hits	167	Target Neighborhood Hits	33	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UGK8, Q9UGK9	Gene names	SERGEF, DELGEF, GNEFR
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

TOIP2_MOUSE
θ value	1.06291 (rank : 66)	NC score	0.027227 (rank : 132)
Query Neighborhood Hits	167	Target Neighborhood Hits	115	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BYU6, Q6NY10, Q8BJP0	Gene names	Tor1aip2
Domain Architecture	No domain graphic available
Description	Torsin-1A-interacting protein 2.

VPS72_HUMAN
θ value	1.06291 (rank : 67)	NC score	0.065281 (rank : 84)
Query Neighborhood Hits	167	Target Neighborhood Hits	274	Shared Neighborhood Hits	15
SwissProt Accessions	Q15906, Q53GJ2, Q5U0R4	Gene names	VPS72, TCFL1, YL1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

ANLN_MOUSE
θ value	1.38821 (rank : 68)	NC score	0.027553 (rank : 129)
Query Neighborhood Hits	167	Target Neighborhood Hits	297	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

CJ012_HUMAN
θ value	1.38821 (rank : 69)	NC score	0.045162 (rank : 111)
Query Neighborhood Hits	167	Target Neighborhood Hits	467	Shared Neighborhood Hits	24
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

DGKK_HUMAN
θ value	1.38821 (rank : 70)	NC score	0.021004 (rank : 152)
Query Neighborhood Hits	167	Target Neighborhood Hits	378	Shared Neighborhood Hits	9
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

FILA_HUMAN
θ value	1.38821 (rank : 71)	NC score	0.035797 (rank : 120)
Query Neighborhood Hits	167	Target Neighborhood Hits	685	Shared Neighborhood Hits	24
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

PELP1_HUMAN
θ value	1.38821 (rank : 72)	NC score	0.039598 (rank : 113)
Query Neighborhood Hits	167	Target Neighborhood Hits	596	Shared Neighborhood Hits	24
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

RCC2_HUMAN
θ value	1.38821 (rank : 73)	NC score	0.103600 (rank : 58)
Query Neighborhood Hits	167	Target Neighborhood Hits	36	Shared Neighborhood Hits	13
SwissProt Accessions	Q9P258, Q8IVL9, Q9BSN6, Q9NPV8	Gene names	RCC2, KIAA1470, TD60
Domain Architecture	No domain graphic available
Description	Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like protein TD- 60).

SAPS1_MOUSE
θ value	1.38821 (rank : 74)	NC score	0.024615 (rank : 145)
Query Neighborhood Hits	167	Target Neighborhood Hits	144	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TSI3, Q80TJ4	Gene names	Saps1, Kiaa1115
Domain Architecture	No domain graphic available
Description	SAPS domain family member 1.

UBR1_HUMAN
θ value	1.38821 (rank : 75)	NC score	0.036844 (rank : 118)
Query Neighborhood Hits	167	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IWV7, O60708, O75492, Q68DN9, Q8IWY6, Q96JY4	Gene names	UBR1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-1 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3- alpha-I).

UBR1_MOUSE
θ value	1.38821 (rank : 76)	NC score	0.036877 (rank : 117)
Query Neighborhood Hits	167	Target Neighborhood Hits	52	Shared Neighborhood Hits	7
SwissProt Accessions	O70481, Q5BKR8, Q792M3, Q8BN40, Q8C5K3	Gene names	Ubr1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-1 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3- alpha-I).

CDR2_HUMAN
θ value	1.81305 (rank : 77)	NC score	0.031911 (rank : 122)
Query Neighborhood Hits	167	Target Neighborhood Hits	404	Shared Neighborhood Hits	10
SwissProt Accessions	Q01850, Q13977	Gene names	CDR2, PCD17
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2 (Paraneoplastic cerebellar degeneration-associated antigen) (Major Yo paraneoplastic antigen).

CDR2_MOUSE
θ value	1.81305 (rank : 78)	NC score	0.025597 (rank : 139)
Query Neighborhood Hits	167	Target Neighborhood Hits	482	Shared Neighborhood Hits	11
SwissProt Accessions	P97817	Gene names	Cdr2
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2.

MUC2_HUMAN
θ value	1.81305 (rank : 79)	NC score	0.017386 (rank : 160)
Query Neighborhood Hits	167	Target Neighborhood Hits	906	Shared Neighborhood Hits	23
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

NRK_HUMAN
θ value	1.81305 (rank : 80)	NC score	0.002522 (rank : 206)
Query Neighborhood Hits	167	Target Neighborhood Hits	931	Shared Neighborhood Hits	15
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

ZIC5_HUMAN
θ value	1.81305 (rank : 81)	NC score	0.000539 (rank : 210)
Query Neighborhood Hits	167	Target Neighborhood Hits	774	Shared Neighborhood Hits	13
SwissProt Accessions	Q96T25	Gene names	ZIC5
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZIC 5 (Zinc finger protein of the cerebellum 5).

ARMX2_HUMAN
θ value	2.36792 (rank : 82)	NC score	0.021076 (rank : 151)
Query Neighborhood Hits	167	Target Neighborhood Hits	134	Shared Neighborhood Hits	7
SwissProt Accessions	Q7L311, O60267, Q5H9D9	Gene names	ARMCX2, ALEX2, KIAA0512
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing X-linked protein 2 (Protein ALEX2) (ARM protein lost in epithelial cancers on chromosome X 2).

BAI1_HUMAN
θ value	2.36792 (rank : 83)	NC score	0.008310 (rank : 194)
Query Neighborhood Hits	167	Target Neighborhood Hits	375	Shared Neighborhood Hits	8
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

CENPF_HUMAN
θ value	2.36792 (rank : 84)	NC score	0.004996 (rank : 202)
Query Neighborhood Hits	167	Target Neighborhood Hits	1932	Shared Neighborhood Hits	25
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

CORO7_HUMAN
θ value	2.36792 (rank : 85)	NC score	0.011953 (rank : 180)
Query Neighborhood Hits	167	Target Neighborhood Hits	315	Shared Neighborhood Hits	5
SwissProt Accessions	P57737	Gene names	CORO7
Domain Architecture
Description	Coronin-7 (70 kDa WD repeat tumor rejection antigen homolog).

ELOA1_HUMAN
θ value	2.36792 (rank : 86)	NC score	0.030596 (rank : 125)
Query Neighborhood Hits	167	Target Neighborhood Hits	388	Shared Neighborhood Hits	18
SwissProt Accessions	Q14241, Q8IXH1	Gene names	TCEB3
Domain Architecture
Description	Transcription elongation factor B polypeptide 3 (RNA polymerase II transcription factor SIII subunit A1) (SIII p110) (Elongin-A) (EloA) (Elongin 110 kDa subunit).

KRA94_HUMAN
θ value	2.36792 (rank : 87)	NC score	0.025558 (rank : 140)
Query Neighborhood Hits	167	Target Neighborhood Hits	204	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BYQ2	Gene names	KRTAP9-4, KAP9.4, KRTAP9.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-4 (Keratin-associated protein 9.4) (Ultrahigh sulfur keratin-associated protein 9.4).

MLL3_HUMAN
θ value	2.36792 (rank : 88)	NC score	0.019245 (rank : 155)
Query Neighborhood Hits	167	Target Neighborhood Hits	1644	Shared Neighborhood Hits	50
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

PSD4_MOUSE
θ value	2.36792 (rank : 89)	NC score	0.012521 (rank : 176)
Query Neighborhood Hits	167	Target Neighborhood Hits	78	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

RP1L1_MOUSE
θ value	2.36792 (rank : 90)	NC score	0.025771 (rank : 137)
Query Neighborhood Hits	167	Target Neighborhood Hits	170	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CGM2, Q8K0I4	Gene names	Rp1l1, Rp1hl1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein (Retinitis pigmentosa 1-like protein 1).

ZBTB4_HUMAN
θ value	2.36792 (rank : 91)	NC score	0.002439 (rank : 207)
Query Neighborhood Hits	167	Target Neighborhood Hits	926	Shared Neighborhood Hits	15
SwissProt Accessions	Q9P1Z0, Q7Z697, Q86XJ4, Q8N4V8	Gene names	ZBTB4, KIAA1538
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 4 (KAISO-like zinc finger protein 1) (KAISO-L1).

CJ046_MOUSE
θ value	3.0926 (rank : 92)	NC score	0.030683 (rank : 124)
Query Neighborhood Hits	167	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R0X2, Q3TE79, Q9CY95	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf46 homolog.

CRCM_HUMAN
θ value	3.0926 (rank : 93)	NC score	0.018946 (rank : 156)
Query Neighborhood Hits	167	Target Neighborhood Hits	520	Shared Neighborhood Hits	12
SwissProt Accessions	P23508	Gene names	MCC
Domain Architecture
Description	Colorectal mutant cancer protein (Protein MCC).

ELL3_HUMAN
θ value	3.0926 (rank : 94)	NC score	0.027392 (rank : 130)
Query Neighborhood Hits	167	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HB65, Q9H634	Gene names	ELL3
Domain Architecture
Description	RNA polymerase II elongation factor ELL3.

ERIC1_HUMAN
θ value	3.0926 (rank : 95)	NC score	0.057649 (rank : 93)
Query Neighborhood Hits	167	Target Neighborhood Hits	364	Shared Neighborhood Hits	23
SwissProt Accessions	Q86X53, Q9P063	Gene names	ERICH1
Domain Architecture	No domain graphic available
Description	Glutamate-rich protein 1.

RIF1_MOUSE
θ value	3.0926 (rank : 96)	NC score	0.027366 (rank : 131)
Query Neighborhood Hits	167	Target Neighborhood Hits	315	Shared Neighborhood Hits	21
SwissProt Accessions	Q6PR54, Q6T8D9, Q7TPD8, Q8BTU2, Q8C408, Q9CS77	Gene names	Rif1
Domain Architecture	No domain graphic available
Description	Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) (mRif1).

SEMG2_HUMAN
θ value	3.0926 (rank : 97)	NC score	0.034127 (rank : 121)
Query Neighborhood Hits	167	Target Neighborhood Hits	251	Shared Neighborhood Hits	11
SwissProt Accessions	Q02383, Q6X2M6	Gene names	SEMG2
Domain Architecture
Description	Semenogelin-2 precursor (Semenogelin II) (SGII).

ADA28_MOUSE
θ value	4.03905 (rank : 98)	NC score	0.008946 (rank : 191)
Query Neighborhood Hits	167	Target Neighborhood Hits	241	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JLN6, Q8K5D2, Q8K5D3	Gene names	Adam28
Domain Architecture
Description	ADAM 28 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 28) (Thymic epithelial cell-ADAM) (TECADAM).

ASH2L_MOUSE
θ value	4.03905 (rank : 99)	NC score	0.023588 (rank : 147)
Query Neighborhood Hits	167	Target Neighborhood Hits	40	Shared Neighborhood Hits	6
SwissProt Accessions	Q91X20, Q3UIF9, Q9Z2X4	Gene names	Ash2l
Domain Architecture
Description	Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein).

ATRX_MOUSE
θ value	4.03905 (rank : 100)	NC score	0.017986 (rank : 159)
Query Neighborhood Hits	167	Target Neighborhood Hits	682	Shared Neighborhood Hits	27
SwissProt Accessions	Q61687	Gene names	Atrx, Hp1bp2, Xnp
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1 alpha-interacting protein) (HP1-BP38 protein).

BSCL2_MOUSE
θ value	4.03905 (rank : 101)	NC score	0.059285 (rank : 90)
Query Neighborhood Hits	167	Target Neighborhood Hits	94	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Z2E9, Q810B0, Q9JJC2, Q9JMF1	Gene names	Bscl2, Gng3lg
Domain Architecture	No domain graphic available
Description	Seipin (Bernardinelli-Seip congenital lipodystrophy type 2 protein homolog).

GGN_HUMAN
θ value	4.03905 (rank : 102)	NC score	0.026144 (rank : 136)
Query Neighborhood Hits	167	Target Neighborhood Hits	269	Shared Neighborhood Hits	11
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

ICAL_MOUSE
θ value	4.03905 (rank : 103)	NC score	0.026923 (rank : 133)
Query Neighborhood Hits	167	Target Neighborhood Hits	178	Shared Neighborhood Hits	11
SwissProt Accessions	P51125, Q9EQV4, Q9EQV5, Q9QXQ3, Q9QXQ4, Q9R0N1	Gene names	Cast
Domain Architecture
Description	Calpastatin (Calpain inhibitor).

INGR1_MOUSE
θ value	4.03905 (rank : 104)	NC score	0.017209 (rank : 161)
Query Neighborhood Hits	167	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	P15261	Gene names	Ifngr1, Ifngr
Domain Architecture
Description	Interferon-gamma receptor alpha chain precursor (IFN-gamma-R1) (CD119 antigen).

K1802_HUMAN
θ value	4.03905 (rank : 105)	NC score	0.015232 (rank : 164)
Query Neighborhood Hits	167	Target Neighborhood Hits	1378	Shared Neighborhood Hits	36
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MYCL1_HUMAN
θ value	4.03905 (rank : 106)	NC score	0.018413 (rank : 157)
Query Neighborhood Hits	167	Target Neighborhood Hits	146	Shared Neighborhood Hits	7
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

NACAM_MOUSE
θ value	4.03905 (rank : 107)	NC score	0.038733 (rank : 114)
Query Neighborhood Hits	167	Target Neighborhood Hits	1866	Shared Neighborhood Hits	64
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

RCC2_MOUSE
θ value	4.03905 (rank : 108)	NC score	0.097915 (rank : 63)
Query Neighborhood Hits	167	Target Neighborhood Hits	37	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BK67, Q6ZPQ0	Gene names	Rcc2, Kiaa1470
Domain Architecture	No domain graphic available
Description	Protein RCC2.

RRBP1_HUMAN
θ value	4.03905 (rank : 109)	NC score	0.008719 (rank : 193)
Query Neighborhood Hits	167	Target Neighborhood Hits	1306	Shared Neighborhood Hits	31
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

SNPC4_HUMAN
θ value	4.03905 (rank : 110)	NC score	0.024673 (rank : 144)
Query Neighborhood Hits	167	Target Neighborhood Hits	589	Shared Neighborhood Hits	26
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

TREF1_HUMAN
θ value	4.03905 (rank : 111)	NC score	0.009500 (rank : 189)
Query Neighborhood Hits	167	Target Neighborhood Hits	651	Shared Neighborhood Hits	12
SwissProt Accessions	Q96PN7, Q7Z6T2, Q7Z6T3, Q9NQ72, Q9NQ73, Q9NUN9	Gene names	TRERF1, RAPA, TREP132
Domain Architecture	No domain graphic available
Description	Transcriptional-regulating factor 1 (Transcriptional-regulating protein 132) (Zinc finger transcription factor TReP-132) (Zinc finger protein rapa).

YES_HUMAN
θ value	4.03905 (rank : 112)	NC score	-0.002884 (rank : 216)
Query Neighborhood Hits	167	Target Neighborhood Hits	1059	Shared Neighborhood Hits	9
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ZBTB1_HUMAN
θ value	4.03905 (rank : 113)	NC score	0.000572 (rank : 209)
Query Neighborhood Hits	167	Target Neighborhood Hits	805	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y2K1, Q86SW8	Gene names	ZBTB1, KIAA0997
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 1.

AB1IP_MOUSE
θ value	5.27518 (rank : 114)	NC score	0.009802 (rank : 188)
Query Neighborhood Hits	167	Target Neighborhood Hits	181	Shared Neighborhood Hits	7
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

ADCY9_HUMAN
θ value	5.27518 (rank : 115)	NC score	0.010109 (rank : 187)
Query Neighborhood Hits	167	Target Neighborhood Hits	51	Shared Neighborhood Hits	3
SwissProt Accessions	O60503, O60273, Q4ZHT9, Q4ZIR5, Q9BWT4, Q9UGP2	Gene names	ADCY9, KIAA0520
Domain Architecture
Description	Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9).

ARI1A_HUMAN
θ value	5.27518 (rank : 116)	NC score	0.020938 (rank : 153)
Query Neighborhood Hits	167	Target Neighborhood Hits	787	Shared Neighborhood Hits	27
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

ATN1_HUMAN
θ value	5.27518 (rank : 117)	NC score	0.019302 (rank : 154)
Query Neighborhood Hits	167	Target Neighborhood Hits	676	Shared Neighborhood Hits	26
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

CHD3_HUMAN
θ value	5.27518 (rank : 118)	NC score	0.009251 (rank : 190)
Query Neighborhood Hits	167	Target Neighborhood Hits	397	Shared Neighborhood Hits	15
SwissProt Accessions	Q12873, Q9Y4I0	Gene names	CHD3
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 3 (EC 3.6.1.-) (ATP- dependent helicase CHD3) (CHD-3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc-finger helicase) (hZFH).

DHX9_HUMAN
θ value	5.27518 (rank : 119)	NC score	0.008831 (rank : 192)
Query Neighborhood Hits	167	Target Neighborhood Hits	62	Shared Neighborhood Hits	3
SwissProt Accessions	Q08211, Q5VY62, Q6PD69, Q99556	Gene names	DHX9, DDX9, NDH2
Domain Architecture
Description	ATP-dependent RNA helicase A (EC 3.6.1.-) (Nuclear DNA helicase II) (NDH II) (DEAH box protein 9).

HCN4_MOUSE
θ value	5.27518 (rank : 120)	NC score	0.005184 (rank : 200)
Query Neighborhood Hits	167	Target Neighborhood Hits	284	Shared Neighborhood Hits	11
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

HRX_HUMAN
θ value	5.27518 (rank : 121)	NC score	0.010916 (rank : 183)
Query Neighborhood Hits	167	Target Neighborhood Hits	825	Shared Neighborhood Hits	19
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

MARK2_HUMAN
θ value	5.27518 (rank : 122)	NC score	-0.001025 (rank : 212)
Query Neighborhood Hits	167	Target Neighborhood Hits	1056	Shared Neighborhood Hits	18
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

MAST1_MOUSE
θ value	5.27518 (rank : 123)	NC score	-0.001646 (rank : 214)
Query Neighborhood Hits	167	Target Neighborhood Hits	1123	Shared Neighborhood Hits	15
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MOES_MOUSE
θ value	5.27518 (rank : 124)	NC score	0.005028 (rank : 201)
Query Neighborhood Hits	167	Target Neighborhood Hits	923	Shared Neighborhood Hits	14
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

NEUM_MOUSE
θ value	5.27518 (rank : 125)	NC score	0.027670 (rank : 128)
Query Neighborhood Hits	167	Target Neighborhood Hits	149	Shared Neighborhood Hits	16
SwissProt Accessions	P06837	Gene names	Gap43, Basp2
Domain Architecture
Description	Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Calmodulin-binding protein P-57).

PCD15_HUMAN
θ value	5.27518 (rank : 126)	NC score	0.003426 (rank : 204)
Query Neighborhood Hits	167	Target Neighborhood Hits	289	Shared Neighborhood Hits	8
SwissProt Accessions	Q96QU1, Q96QT8	Gene names	PCDH15
Domain Architecture
Description	Protocadherin-15 precursor.

PR285_HUMAN
θ value	5.27518 (rank : 127)	NC score	0.014261 (rank : 167)
Query Neighborhood Hits	167	Target Neighborhood Hits	63	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BYK8, Q3C2G2, Q4VXQ1, Q8TEF3, Q96ND3, Q9C094	Gene names	PRIC285, KIAA1769
Domain Architecture
Description	Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein (EC 3.6.1.-) (ATP-dependent helicase PRIC285) (PPAR-alpha- interacting complex protein 285) (PPAR-gamma DBD-interacting protein 1) (PDIP1).

SEMG1_HUMAN
θ value	5.27518 (rank : 128)	NC score	0.043043 (rank : 112)
Query Neighborhood Hits	167	Target Neighborhood Hits	200	Shared Neighborhood Hits	13
SwissProt Accessions	P04279, Q6X4I9, Q6Y809, Q6Y822, Q6Y823, Q86U64, Q96QM3	Gene names	SEMG1, SEMG
Domain Architecture
Description	Semenogelin-1 precursor (Semenogelin I) (SGI) [Contains: Alpha- inhibin-92; Alpha-inhibin-31; Seminal basic protein].

SRGEF_MOUSE
θ value	5.27518 (rank : 129)	NC score	0.101502 (rank : 59)
Query Neighborhood Hits	167	Target Neighborhood Hits	37	Shared Neighborhood Hits	13
SwissProt Accessions	Q80YD6, Q9QXB7	Gene names	Sergef, Delgef, Gnefr
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

T22D4_MOUSE
θ value	5.27518 (rank : 130)	NC score	0.013136 (rank : 174)
Query Neighborhood Hits	167	Target Neighborhood Hits	92	Shared Neighborhood Hits	6
SwissProt Accessions	Q9EQN3	Gene names	Tsc22d4, Tilz2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2).

TRIM6_HUMAN
θ value	5.27518 (rank : 131)	NC score	0.003767 (rank : 203)
Query Neighborhood Hits	167	Target Neighborhood Hits	412	Shared Neighborhood Hits	5
SwissProt Accessions	Q9C030, Q86WZ8, Q9HCR1	Gene names	TRIM6, RNF89
Domain Architecture
Description	Tripartite motif-containing protein 6 (RING finger protein 89).

ZBTB1_MOUSE
θ value	5.27518 (rank : 132)	NC score	0.000296 (rank : 211)
Query Neighborhood Hits	167	Target Neighborhood Hits	795	Shared Neighborhood Hits	9
SwissProt Accessions	Q91VL9, Q8CDP7, Q99LD2	Gene names	Zbtb1
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 1.

ERCC5_MOUSE
θ value	6.88961 (rank : 133)	NC score	0.024608 (rank : 146)
Query Neighborhood Hits	167	Target Neighborhood Hits	206	Shared Neighborhood Hits	12
SwissProt Accessions	P35689, Q61528, Q64248	Gene names	Ercc5, Ercc-5, Xpg
Domain Architecture
Description	DNA-repair protein complementing XP-G cells homolog (Xeroderma pigmentosum group G-complementing protein homolog) (DNA excision repair protein ERCC-5).

FMN1A_MOUSE
θ value	6.88961 (rank : 134)	NC score	0.016287 (rank : 162)
Query Neighborhood Hits	167	Target Neighborhood Hits	423	Shared Neighborhood Hits	17
SwissProt Accessions	Q05860	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoforms I/II/III (Limb deformity protein).

FMN1B_MOUSE
θ value	6.88961 (rank : 135)	NC score	0.014342 (rank : 166)
Query Neighborhood Hits	167	Target Neighborhood Hits	447	Shared Neighborhood Hits	16
SwissProt Accessions	Q05859	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoform IV (Limb deformity protein).

FOXL1_MOUSE
θ value	6.88961 (rank : 136)	NC score	0.005754 (rank : 199)
Query Neighborhood Hits	167	Target Neighborhood Hits	152	Shared Neighborhood Hits	5
SwissProt Accessions	Q64731	Gene names	Foxl1, Fkh6, Fkhl11
Domain Architecture
Description	Forkhead box protein L1 (Forkhead-related protein FKHL11) (Transcription factor FKH-6).

FXL16_HUMAN
θ value	6.88961 (rank : 137)	NC score	0.010614 (rank : 185)
Query Neighborhood Hits	167	Target Neighborhood Hits	85	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N461, Q2MHR2, Q96S14, Q9UJI0	Gene names	FBXL16, C16orf22, FBL16
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 16 (F-box and leucine-rich repeat protein 16).

HDAC6_HUMAN
θ value	6.88961 (rank : 138)	NC score	0.006229 (rank : 197)
Query Neighborhood Hits	167	Target Neighborhood Hits	145	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UBN7	Gene names	HDAC6
Domain Architecture
Description	Histone deacetylase 6 (HD6).

LIMK2_MOUSE
θ value	6.88961 (rank : 139)	NC score	-0.003347 (rank : 218)
Query Neighborhood Hits	167	Target Neighborhood Hits	998	Shared Neighborhood Hits	8
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

MA1A1_MOUSE
θ value	6.88961 (rank : 140)	NC score	0.006072 (rank : 198)
Query Neighborhood Hits	167	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	P45700	Gene names	Man1a1, Man1a
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase).

MAGE1_HUMAN
θ value	6.88961 (rank : 141)	NC score	0.027726 (rank : 127)
Query Neighborhood Hits	167	Target Neighborhood Hits	1389	Shared Neighborhood Hits	52
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MYT1_HUMAN
θ value	6.88961 (rank : 142)	NC score	0.014715 (rank : 165)
Query Neighborhood Hits	167	Target Neighborhood Hits	475	Shared Neighborhood Hits	21
SwissProt Accessions	Q01538, O94922, Q9UPV2	Gene names	MYT1, KIAA0835, KIAA1050, MTF1, MYTI, PLPB1
Domain Architecture
Description	Myelin transcription factor 1 (MyT1) (MyTI) (Proteolipid protein- binding protein) (PLPB1).

PACS1_HUMAN
θ value	6.88961 (rank : 143)	NC score	0.012470 (rank : 177)
Query Neighborhood Hits	167	Target Neighborhood Hits	82	Shared Neighborhood Hits	4
SwissProt Accessions	Q6VY07, Q6PJY6, Q6PKB6, Q7Z590, Q7Z5W4, Q8N8K6, Q96MW0, Q9NW92, Q9ULP5	Gene names	PACS1, KIAA1175
Domain Architecture	No domain graphic available
Description	Phosphofurin acidic cluster sorting protein 1 (PACS-1).

RERE_MOUSE
θ value	6.88961 (rank : 144)	NC score	0.013737 (rank : 171)
Query Neighborhood Hits	167	Target Neighborhood Hits	785	Shared Neighborhood Hits	30
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

TCRG1_MOUSE
θ value	6.88961 (rank : 145)	NC score	0.031048 (rank : 123)
Query Neighborhood Hits	167	Target Neighborhood Hits	947	Shared Neighborhood Hits	30
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

TPR_HUMAN
θ value	6.88961 (rank : 146)	NC score	0.006754 (rank : 196)
Query Neighborhood Hits	167	Target Neighborhood Hits	1921	Shared Neighborhood Hits	34
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

TSNA1_HUMAN
θ value	6.88961 (rank : 147)	NC score	0.018021 (rank : 158)
Query Neighborhood Hits	167	Target Neighborhood Hits	178	Shared Neighborhood Hits	7
SwissProt Accessions	Q96NA8	Gene names	TSNARE1
Domain Architecture	No domain graphic available
Description	t-SNARE domain-containing protein 1.

UBXD3_MOUSE
θ value	6.88961 (rank : 148)	NC score	0.013930 (rank : 169)
Query Neighborhood Hits	167	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BG34, Q3TTR1, Q8BP58, Q8R0B6	Gene names	Ubxd3
Domain Architecture	No domain graphic available
Description	UBX domain-containing protein 3.

ALEX_HUMAN
θ value	8.99809 (rank : 149)	NC score	0.016000 (rank : 163)
Query Neighborhood Hits	167	Target Neighborhood Hits	361	Shared Neighborhood Hits	14
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

AVEN_HUMAN
θ value	8.99809 (rank : 150)	NC score	0.014237 (rank : 168)
Query Neighborhood Hits	167	Target Neighborhood Hits	40	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NQS1	Gene names	AVEN
Domain Architecture	No domain graphic available
Description	Cell death regulator Aven.

C2TA_HUMAN
θ value	8.99809 (rank : 151)	NC score	0.021977 (rank : 149)
Query Neighborhood Hits	167	Target Neighborhood Hits	190	Shared Neighborhood Hits	10
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

CK002_HUMAN
θ value	8.99809 (rank : 152)	NC score	0.012719 (rank : 175)
Query Neighborhood Hits	167	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UID3, Q6PJV5, Q7L8A6, Q8WZ35, Q96DF4, Q96GR3	Gene names	C11orf2, ANG2
Domain Architecture	No domain graphic available
Description	Protein C11orf2 (Another new gene 2 protein).

EPN1_HUMAN
θ value	8.99809 (rank : 153)	NC score	0.006756 (rank : 195)
Query Neighborhood Hits	167	Target Neighborhood Hits	206	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y6I3, Q86ST3, Q9HA18	Gene names	EPN1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (EH domain-binding mitotic phosphoprotein).

FARP2_HUMAN
θ value	8.99809 (rank : 154)	NC score	0.002037 (rank : 208)
Query Neighborhood Hits	167	Target Neighborhood Hits	240	Shared Neighborhood Hits	5
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

IF35_MOUSE
θ value	8.99809 (rank : 155)	NC score	0.010192 (rank : 186)
Query Neighborhood Hits	167	Target Neighborhood Hits	210	Shared Neighborhood Hits	8
SwissProt Accessions	Q9DCH4	Gene names	Eif3s5
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 5 (eIF-3 epsilon) (eIF3 p47 subunit) (eIF3f).

IL16_MOUSE
θ value	8.99809 (rank : 156)	NC score	0.010805 (rank : 184)
Query Neighborhood Hits	167	Target Neighborhood Hits	189	Shared Neighborhood Hits	7
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

KRA93_HUMAN
θ value	8.99809 (rank : 157)	NC score	0.013483 (rank : 172)
Query Neighborhood Hits	167	Target Neighborhood Hits	203	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BYQ3	Gene names	KRTAP9-3, KAP9.3, KRTAP9.3
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-3 (Keratin-associated protein 9.3) (Ultrahigh sulfur keratin-associated protein 9.3).

MARK2_MOUSE
θ value	8.99809 (rank : 158)	NC score	-0.001216 (rank : 213)
Query Neighborhood Hits	167	Target Neighborhood Hits	1018	Shared Neighborhood Hits	20
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

NFX1_HUMAN
θ value	8.99809 (rank : 159)	NC score	0.011077 (rank : 182)
Query Neighborhood Hits	167	Target Neighborhood Hits	405	Shared Neighborhood Hits	11
SwissProt Accessions	Q12986	Gene names	NFX1
Domain Architecture
Description	Transcriptional repressor NF-X1 (EC 6.3.2.-) (Nuclear transcription factor, X box-binding, 1).

RFIP3_HUMAN
θ value	8.99809 (rank : 160)	NC score	0.002851 (rank : 205)
Query Neighborhood Hits	167	Target Neighborhood Hits	1055	Shared Neighborhood Hits	20
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

SC23A_HUMAN
θ value	8.99809 (rank : 161)	NC score	0.012176 (rank : 179)
Query Neighborhood Hits	167	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	Q15436, Q8NE16	Gene names	SEC23A
Domain Architecture
Description	Protein transport protein Sec23A (SEC23-related protein A).

SC23A_MOUSE
θ value	8.99809 (rank : 162)	NC score	0.012191 (rank : 178)
Query Neighborhood Hits	167	Target Neighborhood Hits	16	Shared Neighborhood Hits	4
SwissProt Accessions	Q01405, Q8JZL4	Gene names	Sec23a, Sec23, Sec23r
Domain Architecture
Description	Protein transport protein Sec23A (SEC23-related protein A).

SF3B4_HUMAN
θ value	8.99809 (rank : 163)	NC score	0.058199 (rank : 92)
Query Neighborhood Hits	167	Target Neighborhood Hits	445	Shared Neighborhood Hits	16
SwissProt Accessions	Q15427	Gene names	SF3B4, SAP49
Domain Architecture
Description	Splicing factor 3B subunit 4 (Spliceosome-associated protein 49) (SAP 49) (SF3b50) (Pre-mRNA-splicing factor SF3b 49 kDa subunit).

UBR2_HUMAN
θ value	8.99809 (rank : 164)	NC score	0.025312 (rank : 143)
Query Neighborhood Hits	167	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IWV8, O15057, Q4VXK2, Q5TFH6, Q6P2I2, Q6ZUD0	Gene names	UBR2, C6orf133, KIAA0349
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-2 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3- alpha-II).

UBR2_MOUSE
θ value	8.99809 (rank : 165)	NC score	0.025474 (rank : 141)
Query Neighborhood Hits	167	Target Neighborhood Hits	37	Shared Neighborhood Hits	7
SwissProt Accessions	Q6WKZ8, Q6DIB9, Q80U31, Q8BUL9, Q8CGW0, Q8K2I6, Q8R0V7, Q8R130	Gene names	Ubr2, Kiaa0349
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-2 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3- alpha-II).

ULK1_HUMAN
θ value	8.99809 (rank : 166)	NC score	-0.003260 (rank : 217)
Query Neighborhood Hits	167	Target Neighborhood Hits	1121	Shared Neighborhood Hits	21
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

ZN628_HUMAN
θ value	8.99809 (rank : 167)	NC score	-0.002746 (rank : 215)
Query Neighborhood Hits	167	Target Neighborhood Hits	814	Shared Neighborhood Hits	11
SwissProt Accessions	Q5EBL2, Q86X34	Gene names	ZNF628
Domain Architecture	No domain graphic available
Description	Zinc finger protein 628.

ALS2_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.051321 (rank : 107)
Query Neighborhood Hits	167	Target Neighborhood Hits	121	Shared Neighborhood Hits	14
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

APBB2_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.061752 (rank : 88)
Query Neighborhood Hits	167	Target Neighborhood Hits	96	Shared Neighborhood Hits	16
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

APBB2_MOUSE
θ value	θ > 10 (rank : 170)	NC score	0.059537 (rank : 89)
Query Neighborhood Hits	167	Target Neighborhood Hits	88	Shared Neighborhood Hits	13
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

APC10_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.058252 (rank : 91)
Query Neighborhood Hits	167	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UM13, Q2V500, Q9UG51, Q9Y5R0	Gene names	ANAPC10, APC10
Domain Architecture
Description	Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10).

APC10_MOUSE
θ value	θ > 10 (rank : 172)	NC score	0.055876 (rank : 97)
Query Neighborhood Hits	167	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K2H6, Q9CW24	Gene names	Anapc10, Apc10
Domain Architecture
Description	Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10).

BAG3_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.140699 (rank : 48)
Query Neighborhood Hits	167	Target Neighborhood Hits	314	Shared Neighborhood Hits	23
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

BAG3_MOUSE
θ value	θ > 10 (rank : 174)	NC score	0.121767 (rank : 52)
Query Neighborhood Hits	167	Target Neighborhood Hits	513	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

CUL7_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.070449 (rank : 81)
Query Neighborhood Hits	167	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q14999, Q5T654	Gene names	CUL7, KIAA0076
Domain Architecture
Description	Cullin-7 (CUL-7).

FA62A_MOUSE
θ value	θ > 10 (rank : 176)	NC score	0.054655 (rank : 100)
Query Neighborhood Hits	167	Target Neighborhood Hits	155	Shared Neighborhood Hits	11
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

GAS7_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.092891 (rank : 64)
Query Neighborhood Hits	167	Target Neighborhood Hits	258	Shared Neighborhood Hits	19
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

GAS7_MOUSE
θ value	θ > 10 (rank : 178)	NC score	0.091865 (rank : 65)
Query Neighborhood Hits	167	Target Neighborhood Hits	259	Shared Neighborhood Hits	17
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

K1333_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.055631 (rank : 98)
Query Neighborhood Hits	167	Target Neighborhood Hits	53	Shared Neighborhood Hits	14
SwissProt Accessions	Q5RJY2, Q6ZPT7, Q8BNA4	Gene names	Kiaa1333
Domain Architecture	No domain graphic available
Description	Protein KIAA1333 (EC 6.3.2.-).

MAGI1_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.099283 (rank : 61)
Query Neighborhood Hits	167	Target Neighborhood Hits	388	Shared Neighborhood Hits	22
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI1_MOUSE
θ value	θ > 10 (rank : 181)	NC score	0.100440 (rank : 60)
Query Neighborhood Hits	167	Target Neighborhood Hits	403	Shared Neighborhood Hits	28
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MAGI2_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.099045 (rank : 62)
Query Neighborhood Hits	167	Target Neighborhood Hits	373	Shared Neighborhood Hits	16
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MAGI2_MOUSE
θ value	θ > 10 (rank : 183)	NC score	0.107557 (rank : 57)
Query Neighborhood Hits	167	Target Neighborhood Hits	370	Shared Neighborhood Hits	22
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

NUCL_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.054545 (rank : 101)
Query Neighborhood Hits	167	Target Neighborhood Hits	415	Shared Neighborhood Hits	16
SwissProt Accessions	P19338, Q53SK1, Q8NB06	Gene names	NCL
Domain Architecture
Description	Nucleolin (Protein C23).

NUCL_MOUSE
θ value	θ > 10 (rank : 185)	NC score	0.056046 (rank : 96)
Query Neighborhood Hits	167	Target Neighborhood Hits	425	Shared Neighborhood Hits	18
SwissProt Accessions	P09405, Q548M9, Q61991, Q99K50	Gene names	Ncl, Nuc
Domain Architecture
Description	Nucleolin (Protein C23).

PABP5_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.086678 (rank : 69)
Query Neighborhood Hits	167	Target Neighborhood Hits	212	Shared Neighborhood Hits	5
SwissProt Accessions	Q96DU9, Q6P529, Q9UFE5	Gene names	PABPC5, PABP5
Domain Architecture
Description	Polyadenylate-binding protein 5 (Poly(A)-binding protein 5) (PABP 5).

PARC_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.052612 (rank : 105)
Query Neighborhood Hits	167	Target Neighborhood Hits	148	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).

PARC_MOUSE
θ value	θ > 10 (rank : 188)	NC score	0.055493 (rank : 99)
Query Neighborhood Hits	167	Target Neighborhood Hits	114	Shared Neighborhood Hits	9
SwissProt Accessions	Q80TT8, Q8BKL9, Q8CGC0, Q8R363	Gene names	Parc, Kiaa0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein.

PIN1_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.149777 (rank : 44)
Query Neighborhood Hits	167	Target Neighborhood Hits	59	Shared Neighborhood Hits	14
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PIN1_MOUSE
θ value	θ > 10 (rank : 190)	NC score	0.148645 (rank : 46)
Query Neighborhood Hits	167	Target Neighborhood Hits	60	Shared Neighborhood Hits	13
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PINL_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.175971 (rank : 37)
Query Neighborhood Hits	167	Target Neighborhood Hits	47	Shared Neighborhood Hits	13
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

PKHA5_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.108115 (rank : 56)
Query Neighborhood Hits	167	Target Neighborhood Hits	455	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PRP40_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.086067 (rank : 70)
Query Neighborhood Hits	167	Target Neighborhood Hits	442	Shared Neighborhood Hits	27
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

PRP40_MOUSE
θ value	θ > 10 (rank : 194)	NC score	0.085268 (rank : 71)
Query Neighborhood Hits	167	Target Neighborhood Hits	447	Shared Neighborhood Hits	30
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

RCBT1_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.064999 (rank : 85)
Query Neighborhood Hits	167	Target Neighborhood Hits	158	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NDN9, Q969U9	Gene names	RCBTB1, CLLD7, E4.5
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1) (Chronic lymphocytic leukemia deletion region gene 7 protein) (CLL deletion region gene 7 protein).

RCBT1_MOUSE
θ value	θ > 10 (rank : 196)	NC score	0.066150 (rank : 82)
Query Neighborhood Hits	167	Target Neighborhood Hits	157	Shared Neighborhood Hits	12
SwissProt Accessions	Q6NXM2, Q8BTZ6, Q8BZV0	Gene names	Rcbtb1
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1).

RCC1_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.079600 (rank : 73)
Query Neighborhood Hits	167	Target Neighborhood Hits	47	Shared Neighborhood Hits	10
SwissProt Accessions	P18754	Gene names	RCC1, CHC1
Domain Architecture
Description	Regulator of chromosome condensation (Chromosome condensation protein 1) (Cell cycle regulatory protein).

RCC1_MOUSE
θ value	θ > 10 (rank : 198)	NC score	0.076554 (rank : 75)
Query Neighborhood Hits	167	Target Neighborhood Hits	45	Shared Neighborhood Hits	10
SwissProt Accessions	Q8VE37, Q3UDB6	Gene names	Rcc1, Chc1
Domain Architecture	No domain graphic available
Description	Regulator of chromosome condensation (Chromosome condensation protein 1).

RPGR_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.084711 (rank : 72)
Query Neighborhood Hits	167	Target Neighborhood Hits	279	Shared Neighborhood Hits	24
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

RPGR_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.079373 (rank : 74)
Query Neighborhood Hits	167	Target Neighborhood Hits	281	Shared Neighborhood Hits	25
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

SAV1_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.190588 (rank : 36)
Query Neighborhood Hits	167	Target Neighborhood Hits	51	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.190821 (rank : 35)
Query Neighborhood Hits	167	Target Neighborhood Hits	48	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

SETD2_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.050329 (rank : 108)
Query Neighborhood Hits	167	Target Neighborhood Hits	412	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

STXB4_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.057570 (rank : 94)
Query Neighborhood Hits	167	Target Neighborhood Hits	616	Shared Neighborhood Hits	22
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_MOUSE
θ value	θ > 10 (rank : 205)	NC score	0.056798 (rank : 95)
Query Neighborhood Hits	167	Target Neighborhood Hits	629	Shared Neighborhood Hits	19
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

UN13A_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.052145 (rank : 106)
Query Neighborhood Hits	167	Target Neighborhood Hits	285	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.052831 (rank : 103)
Query Neighborhood Hits	167	Target Neighborhood Hits	217	Shared Neighborhood Hits	11
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.052845 (rank : 102)
Query Neighborhood Hits	167	Target Neighborhood Hits	210	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

WBS16_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.074061 (rank : 77)
Query Neighborhood Hits	167	Target Neighborhood Hits	29	Shared Neighborhood Hits	10
SwissProt Accessions	Q96I51, Q548B1, Q9H0G7	Gene names	WBSCR16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein (RCC1-like G exchanging factor-like protein).

WBS16_MOUSE
θ value	θ > 10 (rank : 210)	NC score	0.075248 (rank : 76)
Query Neighborhood Hits	167	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	Q9CYF5	Gene names	Wbscr16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein homolog.

WWC1_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.160975 (rank : 41)
Query Neighborhood Hits	167	Target Neighborhood Hits	290	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
θ value	θ > 10 (rank : 212)	NC score	0.160886 (rank : 42)
Query Neighborhood Hits	167	Target Neighborhood Hits	290	Shared Neighborhood Hits	18
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

WWOX_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.149137 (rank : 45)
Query Neighborhood Hits	167	Target Neighborhood Hits	115	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

WWOX_MOUSE
θ value	θ > 10 (rank : 214)	NC score	0.147827 (rank : 47)
Query Neighborhood Hits	167	Target Neighborhood Hits	118	Shared Neighborhood Hits	14
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

WWTR1_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.129438 (rank : 50)
Query Neighborhood Hits	167	Target Neighborhood Hits	76	Shared Neighborhood Hits	15
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

WWTR1_MOUSE
θ value	θ > 10 (rank : 216)	NC score	0.130963 (rank : 49)
Query Neighborhood Hits	167	Target Neighborhood Hits	54	Shared Neighborhood Hits	13
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

YAP1_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.123855 (rank : 51)
Query Neighborhood Hits	167	Target Neighborhood Hits	173	Shared Neighborhood Hits	16
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

YAP1_MOUSE
θ value	θ > 10 (rank : 218)	NC score	0.213360 (rank : 34)
Query Neighborhood Hits	167	Target Neighborhood Hits	96	Shared Neighborhood Hits	15
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

Hits sorted by NC score

EDD1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	167	Target Neighborhood Hits	167	Shared Neighborhood Hits	167
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

EDD1_HUMAN
NC score	0.996449 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	167	Target Neighborhood Hits	170	Shared Neighborhood Hits	135
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

K0317_MOUSE
NC score	0.734037 (rank : 3)	θ value	1.37858e-24 (rank : 5)
Query Neighborhood Hits	167	Target Neighborhood Hits	43	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_HUMAN
NC score	0.732745 (rank : 4)	θ value	5.23862e-24 (rank : 6)
Query Neighborhood Hits	167	Target Neighborhood Hits	46	Shared Neighborhood Hits	34
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

UBE3A_MOUSE
NC score	0.705426 (rank : 5)	θ value	2.69047e-20 (rank : 12)
Query Neighborhood Hits	167	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

UBE3C_HUMAN
NC score	0.703674 (rank : 6)	θ value	9.56915e-18 (rank : 18)
Query Neighborhood Hits	167	Target Neighborhood Hits	51	Shared Neighborhood Hits	33
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3A_HUMAN
NC score	0.702195 (rank : 7)	θ value	3.28887e-18 (rank : 17)
Query Neighborhood Hits	167	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3C_MOUSE
NC score	0.701260 (rank : 8)	θ value	4.74913e-17 (rank : 19)
Query Neighborhood Hits	167	Target Neighborhood Hits	48	Shared Neighborhood Hits	33
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

HUWE1_MOUSE
NC score	0.700234 (rank : 9)	θ value	1.62847e-25 (rank : 4)
Query Neighborhood Hits	167	Target Neighborhood Hits	406	Shared Neighborhood Hits	54
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

HUWE1_HUMAN
NC score	0.699896 (rank : 10)	θ value	1.62847e-25 (rank : 3)
Query Neighborhood Hits	167	Target Neighborhood Hits	443	Shared Neighborhood Hits	56
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

SMUF1_HUMAN
NC score	0.689678 (rank : 11)	θ value	2.20094e-22 (rank : 7)
Query Neighborhood Hits	167	Target Neighborhood Hits	135	Shared Neighborhood Hits	33
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
NC score	0.687207 (rank : 12)	θ value	2.20094e-22 (rank : 8)
Query Neighborhood Hits	167	Target Neighborhood Hits	142	Shared Neighborhood Hits	33
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SMUF2_HUMAN
NC score	0.684324 (rank : 13)	θ value	8.36355e-22 (rank : 9)
Query Neighborhood Hits	167	Target Neighborhood Hits	142	Shared Neighborhood Hits	34
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

HECD2_MOUSE
NC score	0.676192 (rank : 14)	θ value	4.59992e-12 (rank : 30)
Query Neighborhood Hits	167	Target Neighborhood Hits	38	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

ITCH_MOUSE
NC score	0.671252 (rank : 15)	θ value	4.58923e-20 (rank : 13)
Query Neighborhood Hits	167	Target Neighborhood Hits	127	Shared Neighborhood Hits	34
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

HECD2_HUMAN
NC score	0.670006 (rank : 16)	θ value	6.64225e-11 (rank : 34)
Query Neighborhood Hits	167	Target Neighborhood Hits	41	Shared Neighborhood Hits	33
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

ITCH_HUMAN
NC score	0.665051 (rank : 17)	θ value	7.82807e-20 (rank : 14)
Query Neighborhood Hits	167	Target Neighborhood Hits	162	Shared Neighborhood Hits	35
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

WWP2_MOUSE
NC score	0.654237 (rank : 18)	θ value	9.90251e-15 (rank : 24)
Query Neighborhood Hits	167	Target Neighborhood Hits	118	Shared Neighborhood Hits	36
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

WWP2_HUMAN
NC score	0.652745 (rank : 19)	θ value	2.20605e-14 (rank : 25)
Query Neighborhood Hits	167	Target Neighborhood Hits	177	Shared Neighborhood Hits	41
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP1_MOUSE
NC score	0.649368 (rank : 20)	θ value	1.09485e-13 (rank : 27)
Query Neighborhood Hits	167	Target Neighborhood Hits	138	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

TRIPC_HUMAN
NC score	0.646610 (rank : 21)	θ value	1.86753e-13 (rank : 28)
Query Neighborhood Hits	167	Target Neighborhood Hits	319	Shared Neighborhood Hits	44
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

WWP1_HUMAN
NC score	0.645148 (rank : 22)	θ value	1.09485e-13 (rank : 26)
Query Neighborhood Hits	167	Target Neighborhood Hits	262	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

HECD3_MOUSE
NC score	0.643348 (rank : 23)	θ value	1.52774e-15 (rank : 22)
Query Neighborhood Hits	167	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_HUMAN
NC score	0.641138 (rank : 24)	θ value	2.60593e-15 (rank : 23)
Query Neighborhood Hits	167	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

NEDD4_MOUSE
NC score	0.640137 (rank : 25)	θ value	2.27762e-19 (rank : 16)
Query Neighborhood Hits	167	Target Neighborhood Hits	212	Shared Neighborhood Hits	34
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

NEDD4_HUMAN
NC score	0.635845 (rank : 26)	θ value	7.82807e-20 (rank : 15)
Query Neighborhood Hits	167	Target Neighborhood Hits	214	Shared Neighborhood Hits	34
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

NED4L_MOUSE
NC score	0.627251 (rank : 27)	θ value	4.15078e-21 (rank : 11)
Query Neighborhood Hits	167	Target Neighborhood Hits	231	Shared Neighborhood Hits	36
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_HUMAN
NC score	0.626426 (rank : 28)	θ value	4.15078e-21 (rank : 10)
Query Neighborhood Hits	167	Target Neighborhood Hits	238	Shared Neighborhood Hits	36
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

HERC3_HUMAN
NC score	0.561811 (rank : 29)	θ value	2.13673e-09 (rank : 35)
Query Neighborhood Hits	167	Target Neighborhood Hits	62	Shared Neighborhood Hits	39
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

HERC5_HUMAN
NC score	0.541591 (rank : 30)	θ value	0.00020696 (rank : 37)
Query Neighborhood Hits	167	Target Neighborhood Hits	66	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HERC2_MOUSE
NC score	0.537684 (rank : 31)	θ value	5.25075e-16 (rank : 20)
Query Neighborhood Hits	167	Target Neighborhood Hits	167	Shared Neighborhood Hits	41
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_HUMAN
NC score	0.534297 (rank : 32)	θ value	8.95645e-16 (rank : 21)
Query Neighborhood Hits	167	Target Neighborhood Hits	163	Shared Neighborhood Hits	41
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HECD1_HUMAN
NC score	0.461428 (rank : 33)	θ value	5.08577e-11 (rank : 32)
Query Neighborhood Hits	167	Target Neighborhood Hits	371	Shared Neighborhood Hits	34
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

YAP1_MOUSE
NC score	0.213360 (rank : 34)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	167	Target Neighborhood Hits	96	Shared Neighborhood Hits	15
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

SAV1_MOUSE
NC score	0.190821 (rank : 35)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	167	Target Neighborhood Hits	48	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

SAV1_HUMAN
NC score	0.190588 (rank : 36)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	167	Target Neighborhood Hits	51	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

PINL_HUMAN
NC score	0.175971 (rank : 37)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	167	Target Neighborhood Hits	47	Shared Neighborhood Hits	13
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

PABP3_HUMAN
NC score	0.171199 (rank : 38)	θ value	2.69671e-12 (rank : 29)
Query Neighborhood Hits	167	Target Neighborhood Hits	259	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H361, Q8NHV0, Q9H086	Gene names	PABPC3, PABP3, PABPL3
Domain Architecture
Description	Polyadenylate-binding protein 3 (Poly(A)-binding protein 3) (PABP 3) (Testis-specific poly(A)-binding protein).

PABP1_HUMAN
NC score	0.163446 (rank : 39)	θ value	5.08577e-11 (rank : 33)
Query Neighborhood Hits	167	Target Neighborhood Hits	269	Shared Neighborhood Hits	8
SwissProt Accessions	P11940, Q15097, Q93004	Gene names	PABPC1, PAB1, PABP1, PABPC2
Domain Architecture
Description	Polyadenylate-binding protein 1 (Poly(A)-binding protein 1) (PABP 1).

PABP1_MOUSE
NC score	0.163426 (rank : 40)	θ value	3.89403e-11 (rank : 31)
Query Neighborhood Hits	167	Target Neighborhood Hits	278	Shared Neighborhood Hits	8
SwissProt Accessions	P29341	Gene names	Pabpc1, Pabp1
Domain Architecture
Description	Polyadenylate-binding protein 1 (Poly(A)-binding protein 1) (PABP 1).

WWC1_HUMAN
NC score	0.160975 (rank : 41)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	167	Target Neighborhood Hits	290	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
NC score	0.160886 (rank : 42)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	167	Target Neighborhood Hits	290	Shared Neighborhood Hits	18
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

PABP4_HUMAN
NC score	0.154581 (rank : 43)	θ value	2.13673e-09 (rank : 36)
Query Neighborhood Hits	167	Target Neighborhood Hits	268	Shared Neighborhood Hits	8
SwissProt Accessions	Q13310, Q6P0N3	Gene names	PABPC4, APP1, PABP4
Domain Architecture
Description	Polyadenylate-binding protein 4 (Poly(A)-binding protein 4) (PABP 4) (Inducible poly(A)-binding protein) (iPABP) (Activated-platelet protein 1) (APP-1).

PIN1_HUMAN
NC score	0.149777 (rank : 44)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	167	Target Neighborhood Hits	59	Shared Neighborhood Hits	14
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

WWOX_HUMAN
NC score	0.149137 (rank : 45)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	167	Target Neighborhood Hits	115	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

PIN1_MOUSE
NC score	0.148645 (rank : 46)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	167	Target Neighborhood Hits	60	Shared Neighborhood Hits	13
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

WWOX_MOUSE
NC score	0.147827 (rank : 47)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	167	Target Neighborhood Hits	118	Shared Neighborhood Hits	14
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

BAG3_HUMAN
NC score	0.140699 (rank : 48)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	167	Target Neighborhood Hits	314	Shared Neighborhood Hits	23
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

WWTR1_MOUSE
NC score	0.130963 (rank : 49)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	167	Target Neighborhood Hits	54	Shared Neighborhood Hits	13
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

WWTR1_HUMAN
NC score	0.129438 (rank : 50)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	167	Target Neighborhood Hits	76	Shared Neighborhood Hits	15
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

YAP1_HUMAN
NC score	0.123855 (rank : 51)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	167	Target Neighborhood Hits	173	Shared Neighborhood Hits	16
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

BAG3_MOUSE
NC score	0.121767 (rank : 52)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	167	Target Neighborhood Hits	513	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

SRGEF_HUMAN
NC score	0.111868 (rank : 53)	θ value	1.06291 (rank : 65)
Query Neighborhood Hits	167	Target Neighborhood Hits	33	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UGK8, Q9UGK9	Gene names	SERGEF, DELGEF, GNEFR
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

FBX11_HUMAN
NC score	0.110166 (rank : 54)	θ value	0.00228821 (rank : 38)
Query Neighborhood Hits	167	Target Neighborhood Hits	72	Shared Neighborhood Hits	3
SwissProt Accessions	Q86XK2, Q8IXG3, Q96E90, Q9H6V8, Q9H9L1, Q9NR14, Q9UFK1, Q9UHI1, Q9UKC2	Gene names	FBXO11, FBX11, VIT1
Domain Architecture
Description	F-box only protein 11 (Vitiligo-associated protein VIT-1).

BSCL2_HUMAN
NC score	0.109119 (rank : 55)	θ value	0.0563607 (rank : 44)
Query Neighborhood Hits	167	Target Neighborhood Hits	148	Shared Neighborhood Hits	12
SwissProt Accessions	Q96G97, Q96SV1, Q9BSQ0	Gene names	BSCL2
Domain Architecture	No domain graphic available
Description	Seipin (Bernardinelli-Seip congenital lipodystrophy type 2 protein).

PKHA5_HUMAN
NC score	0.108115 (rank : 56)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	167	Target Neighborhood Hits	455	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

MAGI2_MOUSE
NC score	0.107557 (rank : 57)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	167	Target Neighborhood Hits	370	Shared Neighborhood Hits	22
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

RCC2_HUMAN
NC score	0.103600 (rank : 58)	θ value	1.38821 (rank : 73)
Query Neighborhood Hits	167	Target Neighborhood Hits	36	Shared Neighborhood Hits	13
SwissProt Accessions	Q9P258, Q8IVL9, Q9BSN6, Q9NPV8	Gene names	RCC2, KIAA1470, TD60
Domain Architecture	No domain graphic available
Description	Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like protein TD- 60).

SRGEF_MOUSE
NC score	0.101502 (rank : 59)	θ value	5.27518 (rank : 129)
Query Neighborhood Hits	167	Target Neighborhood Hits	37	Shared Neighborhood Hits	13
SwissProt Accessions	Q80YD6, Q9QXB7	Gene names	Sergef, Delgef, Gnefr
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

MAGI1_MOUSE
NC score	0.100440 (rank : 60)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	167	Target Neighborhood Hits	403	Shared Neighborhood Hits	28
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MAGI1_HUMAN
NC score	0.099283 (rank : 61)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	167	Target Neighborhood Hits	388	Shared Neighborhood Hits	22
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI2_HUMAN
NC score	0.099045 (rank : 62)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	167	Target Neighborhood Hits	373	Shared Neighborhood Hits	16
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

RCC2_MOUSE
NC score	0.097915 (rank : 63)	θ value	4.03905 (rank : 108)
Query Neighborhood Hits	167	Target Neighborhood Hits	37	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BK67, Q6ZPQ0	Gene names	Rcc2, Kiaa1470
Domain Architecture	No domain graphic available
Description	Protein RCC2.

GAS7_HUMAN
NC score	0.092891 (rank : 64)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	167	Target Neighborhood Hits	258	Shared Neighborhood Hits	19
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

GAS7_MOUSE
NC score	0.091865 (rank : 65)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	167	Target Neighborhood Hits	259	Shared Neighborhood Hits	17
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

RCBT2_MOUSE
NC score	0.089008 (rank : 66)	θ value	0.47712 (rank : 56)
Query Neighborhood Hits	167	Target Neighborhood Hits	156	Shared Neighborhood Hits	12
SwissProt Accessions	Q99LJ7, Q3TUA3, Q8BMG2	Gene names	Rcbtb2, Chc1l
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like).

AKA12_HUMAN
NC score	0.088207 (rank : 67)	θ value	0.0193708 (rank : 39)
Query Neighborhood Hits	167	Target Neighborhood Hits	825	Shared Neighborhood Hits	36
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

RCBT2_HUMAN
NC score	0.087467 (rank : 68)	θ value	0.62314 (rank : 59)
Query Neighborhood Hits	167	Target Neighborhood Hits	158	Shared Neighborhood Hits	12
SwissProt Accessions	O95199	Gene names	RCBTB2, CHC1L, RLG
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like) (CHC1-L) (RCC1-like G exchanging factor).

PABP5_HUMAN
NC score	0.086678 (rank : 69)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	167	Target Neighborhood Hits	212	Shared Neighborhood Hits	5
SwissProt Accessions	Q96DU9, Q6P529, Q9UFE5	Gene names	PABPC5, PABP5
Domain Architecture
Description	Polyadenylate-binding protein 5 (Poly(A)-binding protein 5) (PABP 5).

PRP40_HUMAN
NC score	0.086067 (rank : 70)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	167	Target Neighborhood Hits	442	Shared Neighborhood Hits	27
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

PRP40_MOUSE
NC score	0.085268 (rank : 71)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	167	Target Neighborhood Hits	447	Shared Neighborhood Hits	30
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

RPGR_HUMAN
NC score	0.084711 (rank : 72)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	167	Target Neighborhood Hits	279	Shared Neighborhood Hits	24
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

RCC1_HUMAN
NC score	0.079600 (rank : 73)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	167	Target Neighborhood Hits	47	Shared Neighborhood Hits	10
SwissProt Accessions	P18754	Gene names	RCC1, CHC1
Domain Architecture
Description	Regulator of chromosome condensation (Chromosome condensation protein 1) (Cell cycle regulatory protein).

RPGR_MOUSE
NC score	0.079373 (rank : 74)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	167	Target Neighborhood Hits	281	Shared Neighborhood Hits	25
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

RCC1_MOUSE
NC score	0.076554 (rank : 75)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	167	Target Neighborhood Hits	45	Shared Neighborhood Hits	10
SwissProt Accessions	Q8VE37, Q3UDB6	Gene names	Rcc1, Chc1
Domain Architecture	No domain graphic available
Description	Regulator of chromosome condensation (Chromosome condensation protein 1).

WBS16_MOUSE
NC score	0.075248 (rank : 76)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	167	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	Q9CYF5	Gene names	Wbscr16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein homolog.

WBS16_HUMAN
NC score	0.074061 (rank : 77)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	167	Target Neighborhood Hits	29	Shared Neighborhood Hits	10
SwissProt Accessions	Q96I51, Q548B1, Q9H0G7	Gene names	WBSCR16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein (RCC1-like G exchanging factor-like protein).

VPS72_MOUSE
NC score	0.073531 (rank : 78)	θ value	0.365318 (rank : 55)
Query Neighborhood Hits	167	Target Neighborhood Hits	286	Shared Neighborhood Hits	14
SwissProt Accessions	Q62481, Q3U2N4, Q810A9, Q99K81	Gene names	Vps72, Tcfl1, Yl1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

LEO1_HUMAN
NC score	0.072471 (rank : 79)	θ value	0.0193708 (rank : 40)
Query Neighborhood Hits	167	Target Neighborhood Hits	958	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

DMRTC_HUMAN
NC score	0.070761 (rank : 80)	θ value	0.365318 (rank : 54)
Query Neighborhood Hits	167	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q5HYR2, Q5HYR0, Q5U5K2, Q8N6L3, Q96SD3	Gene names	DMRTC1
Domain Architecture	No domain graphic available
Description	Doublesex- and mab-3-related transcription factor C1.

CUL7_HUMAN
NC score	0.070449 (rank : 81)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	167	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q14999, Q5T654	Gene names	CUL7, KIAA0076
Domain Architecture
Description	Cullin-7 (CUL-7).

RCBT1_MOUSE
NC score	0.066150 (rank : 82)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	167	Target Neighborhood Hits	157	Shared Neighborhood Hits	12
SwissProt Accessions	Q6NXM2, Q8BTZ6, Q8BZV0	Gene names	Rcbtb1
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1).

CGRE1_MOUSE
NC score	0.066077 (rank : 83)	θ value	0.365318 (rank : 53)
Query Neighborhood Hits	167	Target Neighborhood Hits	173	Shared Neighborhood Hits	8
SwissProt Accessions	Q8R1U2, Q9D1K1	Gene names	Cgref1, Cgr11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

VPS72_HUMAN
NC score	0.065281 (rank : 84)	θ value	1.06291 (rank : 67)
Query Neighborhood Hits	167	Target Neighborhood Hits	274	Shared Neighborhood Hits	15
SwissProt Accessions	Q15906, Q53GJ2, Q5U0R4	Gene names	VPS72, TCFL1, YL1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

RCBT1_HUMAN
NC score	0.064999 (rank : 85)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	167	Target Neighborhood Hits	158	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NDN9, Q969U9	Gene names	RCBTB1, CLLD7, E4.5
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1) (Chronic lymphocytic leukemia deletion region gene 7 protein) (CLL deletion region gene 7 protein).

LEO1_MOUSE
NC score	0.064855 (rank : 86)	θ value	0.0330416 (rank : 43)
Query Neighborhood Hits	167	Target Neighborhood Hits	946	Shared Neighborhood Hits	29
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

NSBP1_MOUSE
NC score	0.064520 (rank : 87)	θ value	0.279714 (rank : 51)
Query Neighborhood Hits	167	Target Neighborhood Hits	681	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JL35, O88832, Q8VC71, Q9CUW1	Gene names	Nsbp1, Garp45
Domain Architecture	No domain graphic available
Description	Nucleosome-binding protein 1 (Nucleosome-binding protein 45) (NBP-45) (GARP45 protein).

APBB2_HUMAN
NC score	0.061752 (rank : 88)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	167	Target Neighborhood Hits	96	Shared Neighborhood Hits	16
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

APBB2_MOUSE
NC score	0.059537 (rank : 89)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	167	Target Neighborhood Hits	88	Shared Neighborhood Hits	13
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

BSCL2_MOUSE
NC score	0.059285 (rank : 90)	θ value	4.03905 (rank : 101)
Query Neighborhood Hits	167	Target Neighborhood Hits	94	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Z2E9, Q810B0, Q9JJC2, Q9JMF1	Gene names	Bscl2, Gng3lg
Domain Architecture	No domain graphic available
Description	Seipin (Bernardinelli-Seip congenital lipodystrophy type 2 protein homolog).

APC10_HUMAN
NC score	0.058252 (rank : 91)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	167	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UM13, Q2V500, Q9UG51, Q9Y5R0	Gene names	ANAPC10, APC10
Domain Architecture
Description	Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10).

SF3B4_HUMAN
NC score	0.058199 (rank : 92)	θ value	8.99809 (rank : 163)
Query Neighborhood Hits	167	Target Neighborhood Hits	445	Shared Neighborhood Hits	16
SwissProt Accessions	Q15427	Gene names	SF3B4, SAP49
Domain Architecture
Description	Splicing factor 3B subunit 4 (Spliceosome-associated protein 49) (SAP 49) (SF3b50) (Pre-mRNA-splicing factor SF3b 49 kDa subunit).

ERIC1_HUMAN
NC score	0.057649 (rank : 93)	θ value	3.0926 (rank : 95)
Query Neighborhood Hits	167	Target Neighborhood Hits	364	Shared Neighborhood Hits	23
SwissProt Accessions	Q86X53, Q9P063	Gene names	ERICH1
Domain Architecture	No domain graphic available
Description	Glutamate-rich protein 1.

STXB4_HUMAN
NC score	0.057570 (rank : 94)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	167	Target Neighborhood Hits	616	Shared Neighborhood Hits	22
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_MOUSE
NC score	0.056798 (rank : 95)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	167	Target Neighborhood Hits	629	Shared Neighborhood Hits	19
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

NUCL_MOUSE
NC score	0.056046 (rank : 96)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	167	Target Neighborhood Hits	425	Shared Neighborhood Hits	18
SwissProt Accessions	P09405, Q548M9, Q61991, Q99K50	Gene names	Ncl, Nuc
Domain Architecture
Description	Nucleolin (Protein C23).

APC10_MOUSE
NC score	0.055876 (rank : 97)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	167	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K2H6, Q9CW24	Gene names	Anapc10, Apc10
Domain Architecture
Description	Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10).

K1333_MOUSE
NC score	0.055631 (rank : 98)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	167	Target Neighborhood Hits	53	Shared Neighborhood Hits	14
SwissProt Accessions	Q5RJY2, Q6ZPT7, Q8BNA4	Gene names	Kiaa1333
Domain Architecture	No domain graphic available
Description	Protein KIAA1333 (EC 6.3.2.-).

PARC_MOUSE
NC score	0.055493 (rank : 99)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	167	Target Neighborhood Hits	114	Shared Neighborhood Hits	9
SwissProt Accessions	Q80TT8, Q8BKL9, Q8CGC0, Q8R363	Gene names	Parc, Kiaa0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein.

FA62A_MOUSE
NC score	0.054655 (rank : 100)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	167	Target Neighborhood Hits	155	Shared Neighborhood Hits	11
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

NUCL_HUMAN
NC score	0.054545 (rank : 101)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	167	Target Neighborhood Hits	415	Shared Neighborhood Hits	16
SwissProt Accessions	P19338, Q53SK1, Q8NB06	Gene names	NCL
Domain Architecture
Description	Nucleolin (Protein C23).

UN13B_MOUSE
NC score	0.052845 (rank : 102)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	167	Target Neighborhood Hits	210	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_HUMAN
NC score	0.052831 (rank : 103)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	167	Target Neighborhood Hits	217	Shared Neighborhood Hits	11
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

LYRIC_MOUSE
NC score	0.052657 (rank : 104)	θ value	0.813845 (rank : 61)
Query Neighborhood Hits	167	Target Neighborhood Hits	126	Shared Neighborhood Hits	13
SwissProt Accessions	Q80WJ7, Q3U9F8, Q3UAQ8, Q8BN67, Q8CBT9, Q8CDL0, Q8CGI7, Q9D052	Gene names	Mtdh, Lyric
Domain Architecture	No domain graphic available
Description	Protein LYRIC (Lysine-rich CEACAM1 co-isolated protein) (3D3/LYRIC) (Metastasis adhesion protein) (Metadherin).

PARC_HUMAN
NC score	0.052612 (rank : 105)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	167	Target Neighborhood Hits	148	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).

UN13A_HUMAN
NC score	0.052145 (rank : 106)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	167	Target Neighborhood Hits	285	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

ALS2_HUMAN
NC score	0.051321 (rank : 107)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	167	Target Neighborhood Hits	121	Shared Neighborhood Hits	14
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

SETD2_HUMAN
NC score	0.050329 (rank : 108)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	167	Target Neighborhood Hits	412	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

UBQL4_MOUSE
NC score	0.048311 (rank : 109)	θ value	0.0193708 (rank : 42)
Query Neighborhood Hits	167	Target Neighborhood Hits	99	Shared Neighborhood Hits	4
SwissProt Accessions	Q99NB8, Q8BP88	Gene names	Ubqln4, Ubin
Domain Architecture
Description	Ubiquilin-4 (Ataxin-1 ubiquitin-like-interacting protein A1U).

TNC6B_HUMAN
NC score	0.047174 (rank : 110)	θ value	0.62314 (rank : 60)
Query Neighborhood Hits	167	Target Neighborhood Hits	256	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UPQ9, Q5TH52, Q8TBX2	Gene names	TNRC6B, KIAA1093
Domain Architecture
Description	Trinucleotide repeat-containing 6B protein.

CJ012_HUMAN
NC score	0.045162 (rank : 111)	θ value	1.38821 (rank : 69)
Query Neighborhood Hits	167	Target Neighborhood Hits	467	Shared Neighborhood Hits	24
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

SEMG1_HUMAN
NC score	0.043043 (rank : 112)	θ value	5.27518 (rank : 128)
Query Neighborhood Hits	167	Target Neighborhood Hits	200	Shared Neighborhood Hits	13
SwissProt Accessions	P04279, Q6X4I9, Q6Y809, Q6Y822, Q6Y823, Q86U64, Q96QM3	Gene names	SEMG1, SEMG
Domain Architecture
Description	Semenogelin-1 precursor (Semenogelin I) (SGI) [Contains: Alpha- inhibin-92; Alpha-inhibin-31; Seminal basic protein].

PELP1_HUMAN
NC score	0.039598 (rank : 113)	θ value	1.38821 (rank : 72)
Query Neighborhood Hits	167	Target Neighborhood Hits	596	Shared Neighborhood Hits	24
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

NACAM_MOUSE
NC score	0.038733 (rank : 114)	θ value	4.03905 (rank : 107)
Query Neighborhood Hits	167	Target Neighborhood Hits	1866	Shared Neighborhood Hits	64
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

MUC7_HUMAN
NC score	0.037392 (rank : 115)	θ value	1.06291 (rank : 63)
Query Neighborhood Hits	167	Target Neighborhood Hits	538	Shared Neighborhood Hits	21
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

ENAH_MOUSE
NC score	0.037228 (rank : 116)	θ value	0.0736092 (rank : 46)
Query Neighborhood Hits	167	Target Neighborhood Hits	919	Shared Neighborhood Hits	22
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

UBR1_MOUSE
NC score	0.036877 (rank : 117)	θ value	1.38821 (rank : 76)
Query Neighborhood Hits	167	Target Neighborhood Hits	52	Shared Neighborhood Hits	7
SwissProt Accessions	O70481, Q5BKR8, Q792M3, Q8BN40, Q8C5K3	Gene names	Ubr1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-1 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3- alpha-I).

UBR1_HUMAN
NC score	0.036844 (rank : 118)	θ value	1.38821 (rank : 75)
Query Neighborhood Hits	167	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IWV7, O60708, O75492, Q68DN9, Q8IWY6, Q96JY4	Gene names	UBR1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-1 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3- alpha-I).

JHD2B_HUMAN
NC score	0.036452 (rank : 119)	θ value	0.163984 (rank : 48)
Query Neighborhood Hits	167	Target Neighborhood Hits	171	Shared Neighborhood Hits	8
SwissProt Accessions	Q7LBC6, Q9BVH6, Q9BW93, Q9BZ52, Q9NYF4, Q9UPS0	Gene names	JMJD1B, C5orf7, JHDM2B, KIAA1082
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2B (EC 1.14.11.-) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA).

FILA_HUMAN
NC score	0.035797 (rank : 120)	θ value	1.38821 (rank : 71)
Query Neighborhood Hits	167	Target Neighborhood Hits	685	Shared Neighborhood Hits	24
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

SEMG2_HUMAN
NC score	0.034127 (rank : 121)	θ value	3.0926 (rank : 97)
Query Neighborhood Hits	167	Target Neighborhood Hits	251	Shared Neighborhood Hits	11
SwissProt Accessions	Q02383, Q6X2M6	Gene names	SEMG2
Domain Architecture
Description	Semenogelin-2 precursor (Semenogelin II) (SGII).

CDR2_HUMAN
NC score	0.031911 (rank : 122)	θ value	1.81305 (rank : 77)
Query Neighborhood Hits	167	Target Neighborhood Hits	404	Shared Neighborhood Hits	10
SwissProt Accessions	Q01850, Q13977	Gene names	CDR2, PCD17
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2 (Paraneoplastic cerebellar degeneration-associated antigen) (Major Yo paraneoplastic antigen).

TCRG1_MOUSE
NC score	0.031048 (rank : 123)	θ value	6.88961 (rank : 145)
Query Neighborhood Hits	167	Target Neighborhood Hits	947	Shared Neighborhood Hits	30
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

CJ046_MOUSE
NC score	0.030683 (rank : 124)	θ value	3.0926 (rank : 92)
Query Neighborhood Hits	167	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R0X2, Q3TE79, Q9CY95	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf46 homolog.

ELOA1_HUMAN
NC score	0.030596 (rank : 125)	θ value	2.36792 (rank : 86)
Query Neighborhood Hits	167	Target Neighborhood Hits	388	Shared Neighborhood Hits	18
SwissProt Accessions	Q14241, Q8IXH1	Gene names	TCEB3
Domain Architecture
Description	Transcription elongation factor B polypeptide 3 (RNA polymerase II transcription factor SIII subunit A1) (SIII p110) (Elongin-A) (EloA) (Elongin 110 kDa subunit).

ACCN4_HUMAN
NC score	0.029346 (rank : 126)	θ value	0.0736092 (rank : 45)
Query Neighborhood Hits	167	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q96FT7, Q53SB7, Q6GMS1, Q6PIN9, Q9NQA4	Gene names	ACCN4, ASIC4
Domain Architecture	No domain graphic available
Description	Amiloride-sensitive cation channel 4 (Amiloride-sensitive cation channel 4, pituitary) (Acid-sensing ion channel 4).

MAGE1_HUMAN
NC score	0.027726 (rank : 127)	θ value	6.88961 (rank : 141)
Query Neighborhood Hits	167	Target Neighborhood Hits	1389	Shared Neighborhood Hits	52
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

NEUM_MOUSE
NC score	0.027670 (rank : 128)	θ value	5.27518 (rank : 125)
Query Neighborhood Hits	167	Target Neighborhood Hits	149	Shared Neighborhood Hits	16
SwissProt Accessions	P06837	Gene names	Gap43, Basp2
Domain Architecture
Description	Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Calmodulin-binding protein P-57).

ANLN_MOUSE
NC score	0.027553 (rank : 129)	θ value	1.38821 (rank : 68)
Query Neighborhood Hits	167	Target Neighborhood Hits	297	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

ELL3_HUMAN
NC score	0.027392 (rank : 130)	θ value	3.0926 (rank : 94)
Query Neighborhood Hits	167	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HB65, Q9H634	Gene names	ELL3
Domain Architecture
Description	RNA polymerase II elongation factor ELL3.

RIF1_MOUSE
NC score	0.027366 (rank : 131)	θ value	3.0926 (rank : 96)
Query Neighborhood Hits	167	Target Neighborhood Hits	315	Shared Neighborhood Hits	21
SwissProt Accessions	Q6PR54, Q6T8D9, Q7TPD8, Q8BTU2, Q8C408, Q9CS77	Gene names	Rif1
Domain Architecture	No domain graphic available
Description	Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) (mRif1).

TOIP2_MOUSE
NC score	0.027227 (rank : 132)	θ value	1.06291 (rank : 66)
Query Neighborhood Hits	167	Target Neighborhood Hits	115	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BYU6, Q6NY10, Q8BJP0	Gene names	Tor1aip2
Domain Architecture	No domain graphic available
Description	Torsin-1A-interacting protein 2.

ICAL_MOUSE
NC score	0.026923 (rank : 133)	θ value	4.03905 (rank : 103)
Query Neighborhood Hits	167	Target Neighborhood Hits	178	Shared Neighborhood Hits	11
SwissProt Accessions	P51125, Q9EQV4, Q9EQV5, Q9QXQ3, Q9QXQ4, Q9R0N1	Gene names	Cast
Domain Architecture
Description	Calpastatin (Calpain inhibitor).

WRN_MOUSE
NC score	0.026801 (rank : 134)	θ value	0.813845 (rank : 62)
Query Neighborhood Hits	167	Target Neighborhood Hits	295	Shared Neighborhood Hits	7
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

WDHD1_MOUSE
NC score	0.026394 (rank : 135)	θ value	0.47712 (rank : 57)
Query Neighborhood Hits	167	Target Neighborhood Hits	414	Shared Neighborhood Hits	11
SwissProt Accessions	P59328, Q6P408	Gene names	Wdhd1, And1
Domain Architecture	No domain graphic available
Description	WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA- binding protein 1) (And-1).

GGN_HUMAN
NC score	0.026144 (rank : 136)	θ value	4.03905 (rank : 102)
Query Neighborhood Hits	167	Target Neighborhood Hits	269	Shared Neighborhood Hits	11
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

RP1L1_MOUSE
NC score	0.025771 (rank : 137)	θ value	2.36792 (rank : 90)
Query Neighborhood Hits	167	Target Neighborhood Hits	170	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CGM2, Q8K0I4	Gene names	Rp1l1, Rp1hl1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein (Retinitis pigmentosa 1-like protein 1).

NFH_HUMAN
NC score	0.025651 (rank : 138)	θ value	0.0193708 (rank : 41)
Query Neighborhood Hits	167	Target Neighborhood Hits	1242	Shared Neighborhood Hits	40
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

CDR2_MOUSE
NC score	0.025597 (rank : 139)	θ value	1.81305 (rank : 78)
Query Neighborhood Hits	167	Target Neighborhood Hits	482	Shared Neighborhood Hits	11
SwissProt Accessions	P97817	Gene names	Cdr2
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2.

KRA94_HUMAN
NC score	0.025558 (rank : 140)	θ value	2.36792 (rank : 87)
Query Neighborhood Hits	167	Target Neighborhood Hits	204	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BYQ2	Gene names	KRTAP9-4, KAP9.4, KRTAP9.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-4 (Keratin-associated protein 9.4) (Ultrahigh sulfur keratin-associated protein 9.4).

UBR2_MOUSE
NC score	0.025474 (rank : 141)	θ value	8.99809 (rank : 165)
Query Neighborhood Hits	167	Target Neighborhood Hits	37	Shared Neighborhood Hits	7
SwissProt Accessions	Q6WKZ8, Q6DIB9, Q80U31, Q8BUL9, Q8CGW0, Q8K2I6, Q8R0V7, Q8R130	Gene names	Ubr2, Kiaa0349
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-2 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3- alpha-II).

GNAS1_MOUSE
NC score	0.025439 (rank : 142)	θ value	0.163984 (rank : 47)
Query Neighborhood Hits	167	Target Neighborhood Hits	651	Shared Neighborhood Hits	30
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

UBR2_HUMAN
NC score	0.025312 (rank : 143)	θ value	8.99809 (rank : 164)
Query Neighborhood Hits	167	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IWV8, O15057, Q4VXK2, Q5TFH6, Q6P2I2, Q6ZUD0	Gene names	UBR2, C6orf133, KIAA0349
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-2 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3- alpha-II).

SNPC4_HUMAN
NC score	0.024673 (rank : 144)	θ value	4.03905 (rank : 110)
Query Neighborhood Hits	167	Target Neighborhood Hits	589	Shared Neighborhood Hits	26
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

SAPS1_MOUSE
NC score	0.024615 (rank : 145)	θ value	1.38821 (rank : 74)
Query Neighborhood Hits	167	Target Neighborhood Hits	144	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TSI3, Q80TJ4	Gene names	Saps1, Kiaa1115
Domain Architecture	No domain graphic available
Description	SAPS domain family member 1.

ERCC5_MOUSE
NC score	0.024608 (rank : 146)	θ value	6.88961 (rank : 133)
Query Neighborhood Hits	167	Target Neighborhood Hits	206	Shared Neighborhood Hits	12
SwissProt Accessions	P35689, Q61528, Q64248	Gene names	Ercc5, Ercc-5, Xpg
Domain Architecture
Description	DNA-repair protein complementing XP-G cells homolog (Xeroderma pigmentosum group G-complementing protein homolog) (DNA excision repair protein ERCC-5).

ASH2L_MOUSE
NC score	0.023588 (rank : 147)	θ value	4.03905 (rank : 99)
Query Neighborhood Hits	167	Target Neighborhood Hits	40	Shared Neighborhood Hits	6
SwissProt Accessions	Q91X20, Q3UIF9, Q9Z2X4	Gene names	Ash2l
Domain Architecture
Description	Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein).

PGCA_HUMAN
NC score	0.023547 (rank : 148)	θ value	0.279714 (rank : 52)
Query Neighborhood Hits	167	Target Neighborhood Hits	821	Shared Neighborhood Hits	19
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

C2TA_HUMAN
NC score	0.021977 (rank : 149)	θ value	8.99809 (rank : 151)
Query Neighborhood Hits	167	Target Neighborhood Hits	190	Shared Neighborhood Hits	10
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

PGCA_MOUSE
NC score	0.021556 (rank : 150)	θ value	1.06291 (rank : 64)
Query Neighborhood Hits	167	Target Neighborhood Hits	643	Shared Neighborhood Hits	22
SwissProt Accessions	Q61282, Q64021	Gene names	Agc1, Agc
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP).

ARMX2_HUMAN
NC score	0.021076 (rank : 151)	θ value	2.36792 (rank : 82)
Query Neighborhood Hits	167	Target Neighborhood Hits	134	Shared Neighborhood Hits	7
SwissProt Accessions	Q7L311, O60267, Q5H9D9	Gene names	ARMCX2, ALEX2, KIAA0512
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing X-linked protein 2 (Protein ALEX2) (ARM protein lost in epithelial cancers on chromosome X 2).

DGKK_HUMAN
NC score	0.021004 (rank : 152)	θ value	1.38821 (rank : 70)
Query Neighborhood Hits	167	Target Neighborhood Hits	378	Shared Neighborhood Hits	9
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

ARI1A_HUMAN
NC score	0.020938 (rank : 153)	θ value	5.27518 (rank : 116)
Query Neighborhood Hits	167	Target Neighborhood Hits	787	Shared Neighborhood Hits	27
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

ATN1_HUMAN
NC score	0.019302 (rank : 154)	θ value	5.27518 (rank : 117)
Query Neighborhood Hits	167	Target Neighborhood Hits	676	Shared Neighborhood Hits	26
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

MLL3_HUMAN
NC score	0.019245 (rank : 155)	θ value	2.36792 (rank : 88)
Query Neighborhood Hits	167	Target Neighborhood Hits	1644	Shared Neighborhood Hits	50
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

CRCM_HUMAN
NC score	0.018946 (rank : 156)	θ value	3.0926 (rank : 93)
Query Neighborhood Hits	167	Target Neighborhood Hits	520	Shared Neighborhood Hits	12
SwissProt Accessions	P23508	Gene names	MCC
Domain Architecture
Description	Colorectal mutant cancer protein (Protein MCC).

MYCL1_HUMAN
NC score	0.018413 (rank : 157)	θ value	4.03905 (rank : 106)
Query Neighborhood Hits	167	Target Neighborhood Hits	146	Shared Neighborhood Hits	7
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

TSNA1_HUMAN
NC score	0.018021 (rank : 158)	θ value	6.88961 (rank : 147)
Query Neighborhood Hits	167	Target Neighborhood Hits	178	Shared Neighborhood Hits	7
SwissProt Accessions	Q96NA8	Gene names	TSNARE1
Domain Architecture	No domain graphic available
Description	t-SNARE domain-containing protein 1.

ATRX_MOUSE
NC score	0.017986 (rank : 159)	θ value	4.03905 (rank : 100)
Query Neighborhood Hits	167	Target Neighborhood Hits	682	Shared Neighborhood Hits	27
SwissProt Accessions	Q61687	Gene names	Atrx, Hp1bp2, Xnp
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1 alpha-interacting protein) (HP1-BP38 protein).

MUC2_HUMAN
NC score	0.017386 (rank : 160)	θ value	1.81305 (rank : 79)
Query Neighborhood Hits	167	Target Neighborhood Hits	906	Shared Neighborhood Hits	23
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

INGR1_MOUSE
NC score	0.017209 (rank : 161)	θ value	4.03905 (rank : 104)
Query Neighborhood Hits	167	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	P15261	Gene names	Ifngr1, Ifngr
Domain Architecture
Description	Interferon-gamma receptor alpha chain precursor (IFN-gamma-R1) (CD119 antigen).

FMN1A_MOUSE
NC score	0.016287 (rank : 162)	θ value	6.88961 (rank : 134)
Query Neighborhood Hits	167	Target Neighborhood Hits	423	Shared Neighborhood Hits	17
SwissProt Accessions	Q05860	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoforms I/II/III (Limb deformity protein).

ALEX_HUMAN
NC score	0.016000 (rank : 163)	θ value	8.99809 (rank : 149)
Query Neighborhood Hits	167	Target Neighborhood Hits	361	Shared Neighborhood Hits	14
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

K1802_HUMAN
NC score	0.015232 (rank : 164)	θ value	4.03905 (rank : 105)
Query Neighborhood Hits	167	Target Neighborhood Hits	1378	Shared Neighborhood Hits	36
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MYT1_HUMAN
NC score	0.014715 (rank : 165)	θ value	6.88961 (rank : 142)
Query Neighborhood Hits	167	Target Neighborhood Hits	475	Shared Neighborhood Hits	21
SwissProt Accessions	Q01538, O94922, Q9UPV2	Gene names	MYT1, KIAA0835, KIAA1050, MTF1, MYTI, PLPB1
Domain Architecture
Description	Myelin transcription factor 1 (MyT1) (MyTI) (Proteolipid protein- binding protein) (PLPB1).

FMN1B_MOUSE
NC score	0.014342 (rank : 166)	θ value	6.88961 (rank : 135)
Query Neighborhood Hits	167	Target Neighborhood Hits	447	Shared Neighborhood Hits	16
SwissProt Accessions	Q05859	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoform IV (Limb deformity protein).

PR285_HUMAN
NC score	0.014261 (rank : 167)	θ value	5.27518 (rank : 127)
Query Neighborhood Hits	167	Target Neighborhood Hits	63	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BYK8, Q3C2G2, Q4VXQ1, Q8TEF3, Q96ND3, Q9C094	Gene names	PRIC285, KIAA1769
Domain Architecture
Description	Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein (EC 3.6.1.-) (ATP-dependent helicase PRIC285) (PPAR-alpha- interacting complex protein 285) (PPAR-gamma DBD-interacting protein 1) (PDIP1).

AVEN_HUMAN
NC score	0.014237 (rank : 168)	θ value	8.99809 (rank : 150)
Query Neighborhood Hits	167	Target Neighborhood Hits	40	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NQS1	Gene names	AVEN
Domain Architecture	No domain graphic available
Description	Cell death regulator Aven.

UBXD3_MOUSE
NC score	0.013930 (rank : 169)	θ value	6.88961 (rank : 148)
Query Neighborhood Hits	167	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BG34, Q3TTR1, Q8BP58, Q8R0B6	Gene names	Ubxd3
Domain Architecture	No domain graphic available
Description	UBX domain-containing protein 3.

ADA28_HUMAN
NC score	0.013821 (rank : 170)	θ value	0.62314 (rank : 58)
Query Neighborhood Hits	167	Target Neighborhood Hits	244	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UKQ2, Q9Y339, Q9Y3S0	Gene names	ADAM28, MDCL
Domain Architecture
Description	ADAM 28 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 28) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein-L) (MDC-L) (eMDC II) (ADAM23).

RERE_MOUSE
NC score	0.013737 (rank : 171)	θ value	6.88961 (rank : 144)
Query Neighborhood Hits	167	Target Neighborhood Hits	785	Shared Neighborhood Hits	30
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

KRA93_HUMAN
NC score	0.013483 (rank : 172)	θ value	8.99809 (rank : 157)
Query Neighborhood Hits	167	Target Neighborhood Hits	203	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BYQ3	Gene names	KRTAP9-3, KAP9.3, KRTAP9.3
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-3 (Keratin-associated protein 9.3) (Ultrahigh sulfur keratin-associated protein 9.3).

HXB4_MOUSE
NC score	0.013431 (rank : 173)	θ value	0.279714 (rank : 50)
Query Neighborhood Hits	167	Target Neighborhood Hits	375	Shared Neighborhood Hits	4
SwissProt Accessions	P10284, Q3UZB4, Q4VBG0	Gene names	Hoxb4, Hox-2.6, Hoxb-4
Domain Architecture
Description	Homeobox protein Hox-B4 (Hox-2.6).

T22D4_MOUSE
NC score	0.013136 (rank : 174)	θ value	5.27518 (rank : 130)
Query Neighborhood Hits	167	Target Neighborhood Hits	92	Shared Neighborhood Hits	6
SwissProt Accessions	Q9EQN3	Gene names	Tsc22d4, Tilz2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2).

CK002_HUMAN
NC score	0.012719 (rank : 175)	θ value	8.99809 (rank : 152)
Query Neighborhood Hits	167	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UID3, Q6PJV5, Q7L8A6, Q8WZ35, Q96DF4, Q96GR3	Gene names	C11orf2, ANG2
Domain Architecture	No domain graphic available
Description	Protein C11orf2 (Another new gene 2 protein).

PSD4_MOUSE
NC score	0.012521 (rank : 176)	θ value	2.36792 (rank : 89)
Query Neighborhood Hits	167	Target Neighborhood Hits	78	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

PACS1_HUMAN
NC score	0.012470 (rank : 177)	θ value	6.88961 (rank : 143)
Query Neighborhood Hits	167	Target Neighborhood Hits	82	Shared Neighborhood Hits	4
SwissProt Accessions	Q6VY07, Q6PJY6, Q6PKB6, Q7Z590, Q7Z5W4, Q8N8K6, Q96MW0, Q9NW92, Q9ULP5	Gene names	PACS1, KIAA1175
Domain Architecture	No domain graphic available
Description	Phosphofurin acidic cluster sorting protein 1 (PACS-1).

SC23A_MOUSE
NC score	0.012191 (rank : 178)	θ value	8.99809 (rank : 162)
Query Neighborhood Hits	167	Target Neighborhood Hits	16	Shared Neighborhood Hits	4
SwissProt Accessions	Q01405, Q8JZL4	Gene names	Sec23a, Sec23, Sec23r
Domain Architecture
Description	Protein transport protein Sec23A (SEC23-related protein A).

SC23A_HUMAN
NC score	0.012176 (rank : 179)	θ value	8.99809 (rank : 161)
Query Neighborhood Hits	167	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	Q15436, Q8NE16	Gene names	SEC23A
Domain Architecture
Description	Protein transport protein Sec23A (SEC23-related protein A).

CORO7_HUMAN
NC score	0.011953 (rank : 180)	θ value	2.36792 (rank : 85)
Query Neighborhood Hits	167	Target Neighborhood Hits	315	Shared Neighborhood Hits	5
SwissProt Accessions	P57737	Gene names	CORO7
Domain Architecture
Description	Coronin-7 (70 kDa WD repeat tumor rejection antigen homolog).

PEG3_MOUSE
NC score	0.011216 (rank : 181)	θ value	0.163984 (rank : 49)
Query Neighborhood Hits	167	Target Neighborhood Hits	1101	Shared Neighborhood Hits	27
SwissProt Accessions	Q3URU2, O54978, Q3TQ69, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53	Gene names	Peg3, Kiaa0287, Pw1
Domain Architecture	No domain graphic available
Description	Paternally expressed gene 3 protein (ASF-1).

NFX1_HUMAN
NC score	0.011077 (rank : 182)	θ value	8.99809 (rank : 159)
Query Neighborhood Hits	167	Target Neighborhood Hits	405	Shared Neighborhood Hits	11
SwissProt Accessions	Q12986	Gene names	NFX1
Domain Architecture
Description	Transcriptional repressor NF-X1 (EC 6.3.2.-) (Nuclear transcription factor, X box-binding, 1).

HRX_HUMAN
NC score	0.010916 (rank : 183)	θ value	5.27518 (rank : 121)
Query Neighborhood Hits	167	Target Neighborhood Hits	825	Shared Neighborhood Hits	19
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

IL16_MOUSE
NC score	0.010805 (rank : 184)	θ value	8.99809 (rank : 156)
Query Neighborhood Hits	167	Target Neighborhood Hits	189	Shared Neighborhood Hits	7
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

FXL16_HUMAN
NC score	0.010614 (rank : 185)	θ value	6.88961 (rank : 137)
Query Neighborhood Hits	167	Target Neighborhood Hits	85	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N461, Q2MHR2, Q96S14, Q9UJI0	Gene names	FBXL16, C16orf22, FBL16
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 16 (F-box and leucine-rich repeat protein 16).

IF35_MOUSE
NC score	0.010192 (rank : 186)	θ value	8.99809 (rank : 155)
Query Neighborhood Hits	167	Target Neighborhood Hits	210	Shared Neighborhood Hits	8
SwissProt Accessions	Q9DCH4	Gene names	Eif3s5
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 5 (eIF-3 epsilon) (eIF3 p47 subunit) (eIF3f).

ADCY9_HUMAN
NC score	0.010109 (rank : 187)	θ value	5.27518 (rank : 115)
Query Neighborhood Hits	167	Target Neighborhood Hits	51	Shared Neighborhood Hits	3
SwissProt Accessions	O60503, O60273, Q4ZHT9, Q4ZIR5, Q9BWT4, Q9UGP2	Gene names	ADCY9, KIAA0520
Domain Architecture
Description	Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9).

AB1IP_MOUSE
NC score	0.009802 (rank : 188)	θ value	5.27518 (rank : 114)
Query Neighborhood Hits	167	Target Neighborhood Hits	181	Shared Neighborhood Hits	7
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

TREF1_HUMAN
NC score	0.009500 (rank : 189)	θ value	4.03905 (rank : 111)
Query Neighborhood Hits	167	Target Neighborhood Hits	651	Shared Neighborhood Hits	12
SwissProt Accessions	Q96PN7, Q7Z6T2, Q7Z6T3, Q9NQ72, Q9NQ73, Q9NUN9	Gene names	TRERF1, RAPA, TREP132
Domain Architecture	No domain graphic available
Description	Transcriptional-regulating factor 1 (Transcriptional-regulating protein 132) (Zinc finger transcription factor TReP-132) (Zinc finger protein rapa).

CHD3_HUMAN
NC score	0.009251 (rank : 190)	θ value	5.27518 (rank : 118)
Query Neighborhood Hits	167	Target Neighborhood Hits	397	Shared Neighborhood Hits	15
SwissProt Accessions	Q12873, Q9Y4I0	Gene names	CHD3
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 3 (EC 3.6.1.-) (ATP- dependent helicase CHD3) (CHD-3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc-finger helicase) (hZFH).

ADA28_MOUSE
NC score	0.008946 (rank : 191)	θ value	4.03905 (rank : 98)
Query Neighborhood Hits	167	Target Neighborhood Hits	241	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JLN6, Q8K5D2, Q8K5D3	Gene names	Adam28
Domain Architecture
Description	ADAM 28 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 28) (Thymic epithelial cell-ADAM) (TECADAM).

DHX9_HUMAN
NC score	0.008831 (rank : 192)	θ value	5.27518 (rank : 119)
Query Neighborhood Hits	167	Target Neighborhood Hits	62	Shared Neighborhood Hits	3
SwissProt Accessions	Q08211, Q5VY62, Q6PD69, Q99556	Gene names	DHX9, DDX9, NDH2
Domain Architecture
Description	ATP-dependent RNA helicase A (EC 3.6.1.-) (Nuclear DNA helicase II) (NDH II) (DEAH box protein 9).

RRBP1_HUMAN
NC score	0.008719 (rank : 193)	θ value	4.03905 (rank : 109)
Query Neighborhood Hits	167	Target Neighborhood Hits	1306	Shared Neighborhood Hits	31
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

BAI1_HUMAN
NC score	0.008310 (rank : 194)	θ value	2.36792 (rank : 83)
Query Neighborhood Hits	167	Target Neighborhood Hits	375	Shared Neighborhood Hits	8
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

EPN1_HUMAN
NC score	0.006756 (rank : 195)	θ value	8.99809 (rank : 153)
Query Neighborhood Hits	167	Target Neighborhood Hits	206	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y6I3, Q86ST3, Q9HA18	Gene names	EPN1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (EH domain-binding mitotic phosphoprotein).

TPR_HUMAN
NC score	0.006754 (rank : 196)	θ value	6.88961 (rank : 146)
Query Neighborhood Hits	167	Target Neighborhood Hits	1921	Shared Neighborhood Hits	34
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

HDAC6_HUMAN
NC score	0.006229 (rank : 197)	θ value	6.88961 (rank : 138)
Query Neighborhood Hits	167	Target Neighborhood Hits	145	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UBN7	Gene names	HDAC6
Domain Architecture
Description	Histone deacetylase 6 (HD6).

MA1A1_MOUSE
NC score	0.006072 (rank : 198)	θ value	6.88961 (rank : 140)
Query Neighborhood Hits	167	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	P45700	Gene names	Man1a1, Man1a
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase).

FOXL1_MOUSE
NC score	0.005754 (rank : 199)	θ value	6.88961 (rank : 136)
Query Neighborhood Hits	167	Target Neighborhood Hits	152	Shared Neighborhood Hits	5
SwissProt Accessions	Q64731	Gene names	Foxl1, Fkh6, Fkhl11
Domain Architecture
Description	Forkhead box protein L1 (Forkhead-related protein FKHL11) (Transcription factor FKH-6).

HCN4_MOUSE
NC score	0.005184 (rank : 200)	θ value	5.27518 (rank : 120)
Query Neighborhood Hits	167	Target Neighborhood Hits	284	Shared Neighborhood Hits	11
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

MOES_MOUSE
NC score	0.005028 (rank : 201)	θ value	5.27518 (rank : 124)
Query Neighborhood Hits	167	Target Neighborhood Hits	923	Shared Neighborhood Hits	14
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

CENPF_HUMAN
NC score	0.004996 (rank : 202)	θ value	2.36792 (rank : 84)
Query Neighborhood Hits	167	Target Neighborhood Hits	1932	Shared Neighborhood Hits	25
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

TRIM6_HUMAN
NC score	0.003767 (rank : 203)	θ value	5.27518 (rank : 131)
Query Neighborhood Hits	167	Target Neighborhood Hits	412	Shared Neighborhood Hits	5
SwissProt Accessions	Q9C030, Q86WZ8, Q9HCR1	Gene names	TRIM6, RNF89
Domain Architecture
Description	Tripartite motif-containing protein 6 (RING finger protein 89).

PCD15_HUMAN
NC score	0.003426 (rank : 204)	θ value	5.27518 (rank : 126)
Query Neighborhood Hits	167	Target Neighborhood Hits	289	Shared Neighborhood Hits	8
SwissProt Accessions	Q96QU1, Q96QT8	Gene names	PCDH15
Domain Architecture
Description	Protocadherin-15 precursor.

RFIP3_HUMAN
NC score	0.002851 (rank : 205)	θ value	8.99809 (rank : 160)
Query Neighborhood Hits	167	Target Neighborhood Hits	1055	Shared Neighborhood Hits	20
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

NRK_HUMAN
NC score	0.002522 (rank : 206)	θ value	1.81305 (rank : 80)
Query Neighborhood Hits	167	Target Neighborhood Hits	931	Shared Neighborhood Hits	15
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

ZBTB4_HUMAN
NC score	0.002439 (rank : 207)	θ value	2.36792 (rank : 91)
Query Neighborhood Hits	167	Target Neighborhood Hits	926	Shared Neighborhood Hits	15
SwissProt Accessions	Q9P1Z0, Q7Z697, Q86XJ4, Q8N4V8	Gene names	ZBTB4, KIAA1538
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 4 (KAISO-like zinc finger protein 1) (KAISO-L1).

FARP2_HUMAN
NC score	0.002037 (rank : 208)	θ value	8.99809 (rank : 154)
Query Neighborhood Hits	167	Target Neighborhood Hits	240	Shared Neighborhood Hits	5
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ZBTB1_HUMAN
NC score	0.000572 (rank : 209)	θ value	4.03905 (rank : 113)
Query Neighborhood Hits	167	Target Neighborhood Hits	805	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y2K1, Q86SW8	Gene names	ZBTB1, KIAA0997
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 1.

ZIC5_HUMAN
NC score	0.000539 (rank : 210)	θ value	1.81305 (rank : 81)
Query Neighborhood Hits	167	Target Neighborhood Hits	774	Shared Neighborhood Hits	13
SwissProt Accessions	Q96T25	Gene names	ZIC5
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZIC 5 (Zinc finger protein of the cerebellum 5).

ZBTB1_MOUSE
NC score	0.000296 (rank : 211)	θ value	5.27518 (rank : 132)
Query Neighborhood Hits	167	Target Neighborhood Hits	795	Shared Neighborhood Hits	9
SwissProt Accessions	Q91VL9, Q8CDP7, Q99LD2	Gene names	Zbtb1
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 1.

MARK2_HUMAN
NC score	-0.001025 (rank : 212)	θ value	5.27518 (rank : 122)
Query Neighborhood Hits	167	Target Neighborhood Hits	1056	Shared Neighborhood Hits	18
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

MARK2_MOUSE
NC score	-0.001216 (rank : 213)	θ value	8.99809 (rank : 158)
Query Neighborhood Hits	167	Target Neighborhood Hits	1018	Shared Neighborhood Hits	20
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

MAST1_MOUSE
NC score	-0.001646 (rank : 214)	θ value	5.27518 (rank : 123)
Query Neighborhood Hits	167	Target Neighborhood Hits	1123	Shared Neighborhood Hits	15
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

ZN628_HUMAN
NC score	-0.002746 (rank : 215)	θ value	8.99809 (rank : 167)
Query Neighborhood Hits	167	Target Neighborhood Hits	814	Shared Neighborhood Hits	11
SwissProt Accessions	Q5EBL2, Q86X34	Gene names	ZNF628
Domain Architecture	No domain graphic available
Description	Zinc finger protein 628.

YES_HUMAN
NC score	-0.002884 (rank : 216)	θ value	4.03905 (rank : 112)
Query Neighborhood Hits	167	Target Neighborhood Hits	1059	Shared Neighborhood Hits	9
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ULK1_HUMAN
NC score	-0.003260 (rank : 217)	θ value	8.99809 (rank : 166)
Query Neighborhood Hits	167	Target Neighborhood Hits	1121	Shared Neighborhood Hits	21
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

LIMK2_MOUSE
NC score	-0.003347 (rank : 218)	θ value	6.88961 (rank : 139)
Query Neighborhood Hits	167	Target Neighborhood Hits	998	Shared Neighborhood Hits	8
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).