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Network neighborhood for query Sequence : HECD1_HUMAN

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HECD1_HUMAN
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HECD1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	371	Target Neighborhood Hits	371	Shared Neighborhood Hits	371
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

TRIPC_HUMAN
θ value	9.18288e-45 (rank : 2)	NC score	0.593067 (rank : 107)
Query Neighborhood Hits	371	Target Neighborhood Hits	319	Shared Neighborhood Hits	43
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

UBE3A_HUMAN
θ value	9.54697e-26 (rank : 3)	NC score	0.596869 (rank : 99)
Query Neighborhood Hits	371	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

WWP2_HUMAN
θ value	6.18819e-25 (rank : 4)	NC score	0.564506 (rank : 141)
Query Neighborhood Hits	371	Target Neighborhood Hits	177	Shared Neighborhood Hits	38
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP1_HUMAN
θ value	8.08199e-25 (rank : 5)	NC score	0.558530 (rank : 153)
Query Neighborhood Hits	371	Target Neighborhood Hits	262	Shared Neighborhood Hits	35
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

WWP1_MOUSE
θ value	8.08199e-25 (rank : 6)	NC score	0.563312 (rank : 144)
Query Neighborhood Hits	371	Target Neighborhood Hits	138	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

ITCH_MOUSE
θ value	6.84181e-24 (rank : 7)	NC score	0.566360 (rank : 138)
Query Neighborhood Hits	371	Target Neighborhood Hits	127	Shared Neighborhood Hits	34
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

WWP2_MOUSE
θ value	6.84181e-24 (rank : 8)	NC score	0.563211 (rank : 145)
Query Neighborhood Hits	371	Target Neighborhood Hits	118	Shared Neighborhood Hits	33
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

NED4L_HUMAN
θ value	2.59989e-23 (rank : 9)	NC score	0.518727 (rank : 186)
Query Neighborhood Hits	371	Target Neighborhood Hits	238	Shared Neighborhood Hits	34
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
θ value	2.59989e-23 (rank : 10)	NC score	0.519353 (rank : 185)
Query Neighborhood Hits	371	Target Neighborhood Hits	231	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

UBE3C_HUMAN
θ value	5.79196e-23 (rank : 11)	NC score	0.588085 (rank : 112)
Query Neighborhood Hits	371	Target Neighborhood Hits	51	Shared Neighborhood Hits	35
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

ITCH_HUMAN
θ value	1.6852e-22 (rank : 12)	NC score	0.560570 (rank : 150)
Query Neighborhood Hits	371	Target Neighborhood Hits	162	Shared Neighborhood Hits	35
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

UBE3C_MOUSE
θ value	1.6852e-22 (rank : 13)	NC score	0.587322 (rank : 115)
Query Neighborhood Hits	371	Target Neighborhood Hits	48	Shared Neighborhood Hits	35
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3A_MOUSE
θ value	2.20094e-22 (rank : 14)	NC score	0.591843 (rank : 108)
Query Neighborhood Hits	371	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

HUWE1_HUMAN
θ value	2.06002e-20 (rank : 15)	NC score	0.556768 (rank : 158)
Query Neighborhood Hits	371	Target Neighborhood Hits	443	Shared Neighborhood Hits	52
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	2.06002e-20 (rank : 16)	NC score	0.556719 (rank : 159)
Query Neighborhood Hits	371	Target Neighborhood Hits	406	Shared Neighborhood Hits	47
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

HERC2_MOUSE
θ value	8.65492e-19 (rank : 17)	NC score	0.449229 (rank : 230)
Query Neighborhood Hits	371	Target Neighborhood Hits	167	Shared Neighborhood Hits	43
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

SMUF2_HUMAN
θ value	8.65492e-19 (rank : 18)	NC score	0.558970 (rank : 152)
Query Neighborhood Hits	371	Target Neighborhood Hits	142	Shared Neighborhood Hits	34
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

HERC2_HUMAN
θ value	2.5182e-18 (rank : 19)	NC score	0.446430 (rank : 233)
Query Neighborhood Hits	371	Target Neighborhood Hits	163	Shared Neighborhood Hits	41
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HECD2_HUMAN
θ value	9.56915e-18 (rank : 20)	NC score	0.579681 (rank : 124)
Query Neighborhood Hits	371	Target Neighborhood Hits	41	Shared Neighborhood Hits	34
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

NEDD4_HUMAN
θ value	1.24977e-17 (rank : 21)	NC score	0.523249 (rank : 181)
Query Neighborhood Hits	371	Target Neighborhood Hits	214	Shared Neighborhood Hits	35
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

NEDD4_MOUSE
θ value	2.7842e-17 (rank : 22)	NC score	0.526236 (rank : 179)
Query Neighborhood Hits	371	Target Neighborhood Hits	212	Shared Neighborhood Hits	34
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

HECD2_MOUSE
θ value	1.058e-16 (rank : 23)	NC score	0.580139 (rank : 123)
Query Neighborhood Hits	371	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HERC3_HUMAN
θ value	6.85773e-16 (rank : 24)	NC score	0.483499 (rank : 208)
Query Neighborhood Hits	371	Target Neighborhood Hits	62	Shared Neighborhood Hits	35
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

SMUF1_HUMAN
θ value	6.85773e-16 (rank : 25)	NC score	0.559128 (rank : 151)
Query Neighborhood Hits	371	Target Neighborhood Hits	135	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
θ value	6.85773e-16 (rank : 26)	NC score	0.557149 (rank : 157)
Query Neighborhood Hits	371	Target Neighborhood Hits	142	Shared Neighborhood Hits	35
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

K0317_HUMAN
θ value	2.20605e-14 (rank : 27)	NC score	0.564776 (rank : 140)
Query Neighborhood Hits	371	Target Neighborhood Hits	46	Shared Neighborhood Hits	35
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
θ value	4.91457e-14 (rank : 28)	NC score	0.563952 (rank : 142)
Query Neighborhood Hits	371	Target Neighborhood Hits	43	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

ANR39_HUMAN
θ value	1.02475e-11 (rank : 29)	NC score	0.668495 (rank : 2)
Query Neighborhood Hits	371	Target Neighborhood Hits	285	Shared Neighborhood Hits	268
SwissProt Accessions	Q53RE8, Q59FU2, Q8N5X5, Q9P0S5	Gene names	ANKRD39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ANR39_MOUSE
θ value	2.98157e-11 (rank : 30)	NC score	0.666839 (rank : 3)
Query Neighborhood Hits	371	Target Neighborhood Hits	284	Shared Neighborhood Hits	266
SwissProt Accessions	Q9D2X0	Gene names	Ankrd39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

EDD1_HUMAN
θ value	5.08577e-11 (rank : 31)	NC score	0.459930 (rank : 221)
Query Neighborhood Hits	371	Target Neighborhood Hits	170	Shared Neighborhood Hits	34
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

EDD1_MOUSE
θ value	5.08577e-11 (rank : 32)	NC score	0.461428 (rank : 220)
Query Neighborhood Hits	371	Target Neighborhood Hits	167	Shared Neighborhood Hits	34
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

ACBD6_MOUSE
θ value	6.64225e-11 (rank : 33)	NC score	0.630055 (rank : 27)
Query Neighborhood Hits	371	Target Neighborhood Hits	305	Shared Neighborhood Hits	269
SwissProt Accessions	Q9D061, Q3TMN7, Q9DCU4	Gene names	Acbd6
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 6.

TNKS2_HUMAN
θ value	6.64225e-11 (rank : 34)	NC score	0.638601 (rank : 8)
Query Neighborhood Hits	371	Target Neighborhood Hits	361	Shared Neighborhood Hits	273
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

HERC5_HUMAN
θ value	1.133e-10 (rank : 35)	NC score	0.478028 (rank : 213)
Query Neighborhood Hits	371	Target Neighborhood Hits	66	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

ACBD6_HUMAN
θ value	1.9326e-10 (rank : 36)	NC score	0.625707 (rank : 38)
Query Neighborhood Hits	371	Target Neighborhood Hits	304	Shared Neighborhood Hits	267
SwissProt Accessions	Q9BR61	Gene names	ACBD6
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 6.

NOTC1_HUMAN
θ value	1.63604e-09 (rank : 37)	NC score	0.330967 (rank : 280)
Query Neighborhood Hits	371	Target Neighborhood Hits	906	Shared Neighborhood Hits	271
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

TNKS1_HUMAN
θ value	2.13673e-09 (rank : 38)	NC score	0.633431 (rank : 19)
Query Neighborhood Hits	371	Target Neighborhood Hits	477	Shared Neighborhood Hits	273
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

NOTC3_HUMAN
θ value	2.79066e-09 (rank : 39)	NC score	0.333146 (rank : 278)
Query Neighborhood Hits	371	Target Neighborhood Hits	1062	Shared Neighborhood Hits	274
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

NOTC3_MOUSE
θ value	3.64472e-09 (rank : 40)	NC score	0.334975 (rank : 277)
Query Neighborhood Hits	371	Target Neighborhood Hits	975	Shared Neighborhood Hits	274
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

NOTC2_HUMAN
θ value	4.76016e-09 (rank : 41)	NC score	0.330483 (rank : 281)
Query Neighborhood Hits	371	Target Neighborhood Hits	1113	Shared Neighborhood Hits	269
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

NOTC2_MOUSE
θ value	4.76016e-09 (rank : 42)	NC score	0.329429 (rank : 283)
Query Neighborhood Hits	371	Target Neighborhood Hits	1069	Shared Neighborhood Hits	272
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

PSD10_MOUSE
θ value	6.21693e-09 (rank : 43)	NC score	0.658925 (rank : 5)
Query Neighborhood Hits	371	Target Neighborhood Hits	293	Shared Neighborhood Hits	268
SwissProt Accessions	Q9Z2X2, Q9D7N8	Gene names	Psmd10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

PSD10_HUMAN
θ value	8.11959e-09 (rank : 44)	NC score	0.659023 (rank : 4)
Query Neighborhood Hits	371	Target Neighborhood Hits	301	Shared Neighborhood Hits	270
SwissProt Accessions	O75832	Gene names	PSMD10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

ANR28_HUMAN
θ value	1.06045e-08 (rank : 45)	NC score	0.634110 (rank : 18)
Query Neighborhood Hits	371	Target Neighborhood Hits	314	Shared Neighborhood Hits	272
SwissProt Accessions	O15084, Q6ULS0, Q6ZT57	Gene names	ANKRD28, KIAA0379
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ANR28_MOUSE
θ value	1.06045e-08 (rank : 46)	NC score	0.634664 (rank : 16)
Query Neighborhood Hits	371	Target Neighborhood Hits	314	Shared Neighborhood Hits	272
SwissProt Accessions	Q505D1	Gene names	Ankrd28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ANS4B_HUMAN
θ value	1.06045e-08 (rank : 47)	NC score	0.607207 (rank : 80)
Query Neighborhood Hits	371	Target Neighborhood Hits	289	Shared Neighborhood Hits	254
SwissProt Accessions	Q8N8V4	Gene names	ANKS4B, HARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

DAPK1_MOUSE
θ value	1.38499e-08 (rank : 48)	NC score	0.288116 (rank : 297)
Query Neighborhood Hits	371	Target Neighborhood Hits	1138	Shared Neighborhood Hits	275
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

MIB1_HUMAN
θ value	1.38499e-08 (rank : 49)	NC score	0.617426 (rank : 62)
Query Neighborhood Hits	371	Target Neighborhood Hits	470	Shared Neighborhood Hits	275
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

MIB1_MOUSE
θ value	1.38499e-08 (rank : 50)	NC score	0.617230 (rank : 63)
Query Neighborhood Hits	371	Target Neighborhood Hits	471	Shared Neighborhood Hits	275
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

ANS4B_MOUSE
θ value	1.80886e-08 (rank : 51)	NC score	0.597826 (rank : 98)
Query Neighborhood Hits	371	Target Neighborhood Hits	294	Shared Neighborhood Hits	249
SwissProt Accessions	Q8K3X6, Q9D8A5	Gene names	Anks4b, Harp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

NOTC1_MOUSE
θ value	1.80886e-08 (rank : 52)	NC score	0.287594 (rank : 298)
Query Neighborhood Hits	371	Target Neighborhood Hits	916	Shared Neighborhood Hits	255
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

ANK2_HUMAN
θ value	2.36244e-08 (rank : 53)	NC score	0.583458 (rank : 119)
Query Neighborhood Hits	371	Target Neighborhood Hits	1615	Shared Neighborhood Hits	289
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

ANKS6_HUMAN
θ value	3.08544e-08 (rank : 54)	NC score	0.624433 (rank : 46)
Query Neighborhood Hits	371	Target Neighborhood Hits	411	Shared Neighborhood Hits	267
SwissProt Accessions	Q68DC2, Q5VSL0, Q5VSL2, Q5VSL3, Q5VSL4, Q68DB8, Q6P2R2, Q8N9L6, Q96D62	Gene names	ANKS6, ANKRD14, SAMD6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6) (Ankyrin repeat domain-containing protein 14).

ANR44_HUMAN
θ value	3.08544e-08 (rank : 55)	NC score	0.634280 (rank : 17)
Query Neighborhood Hits	371	Target Neighborhood Hits	318	Shared Neighborhood Hits	272
SwissProt Accessions	Q8N8A2, Q6P480, Q86VL5, Q8IZ72, Q9UFA4	Gene names	ANKRD44
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 44.

ANK1_HUMAN
θ value	4.0297e-08 (rank : 56)	NC score	0.624461 (rank : 45)
Query Neighborhood Hits	371	Target Neighborhood Hits	416	Shared Neighborhood Hits	273
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

ANK3_HUMAN
θ value	4.0297e-08 (rank : 57)	NC score	0.620072 (rank : 59)
Query Neighborhood Hits	371	Target Neighborhood Hits	853	Shared Neighborhood Hits	281
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

NOTC4_MOUSE
θ value	4.0297e-08 (rank : 58)	NC score	0.362351 (rank : 268)
Query Neighborhood Hits	371	Target Neighborhood Hits	872	Shared Neighborhood Hits	272
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

ANR50_HUMAN
θ value	5.26297e-08 (rank : 59)	NC score	0.645332 (rank : 7)
Query Neighborhood Hits	371	Target Neighborhood Hits	361	Shared Neighborhood Hits	274
SwissProt Accessions	Q9ULJ7, Q6N064, Q6ZSE6	Gene names	ANKRD50, KIAA1223
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 50.

ANR52_MOUSE
θ value	5.26297e-08 (rank : 60)	NC score	0.626684 (rank : 34)
Query Neighborhood Hits	371	Target Neighborhood Hits	318	Shared Neighborhood Hits	273
SwissProt Accessions	Q8BTI7	Gene names	Ankrd52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

NOTC4_HUMAN
θ value	5.26297e-08 (rank : 61)	NC score	0.358402 (rank : 269)
Query Neighborhood Hits	371	Target Neighborhood Hits	905	Shared Neighborhood Hits	273
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

ANR35_HUMAN
θ value	6.87365e-08 (rank : 62)	NC score	0.582193 (rank : 120)
Query Neighborhood Hits	371	Target Neighborhood Hits	784	Shared Neighborhood Hits	273
SwissProt Accessions	Q8N283, Q3MJ10, Q96LS3	Gene names	ANKRD35
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 35.

MYPT1_HUMAN
θ value	8.97725e-08 (rank : 63)	NC score	0.607745 (rank : 79)
Query Neighborhood Hits	371	Target Neighborhood Hits	723	Shared Neighborhood Hits	271
SwissProt Accessions	O14974, Q86WU3, Q8NFR6, Q9BYH0	Gene names	PPP1R12A, MBS, MYPT1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit).

MYPT1_MOUSE
θ value	8.97725e-08 (rank : 64)	NC score	0.620562 (rank : 57)
Query Neighborhood Hits	371	Target Neighborhood Hits	539	Shared Neighborhood Hits	270
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

ANR42_MOUSE
θ value	1.17247e-07 (rank : 65)	NC score	0.635272 (rank : 15)
Query Neighborhood Hits	371	Target Neighborhood Hits	334	Shared Neighborhood Hits	270
SwissProt Accessions	Q3V096, Q8BX55, Q8BZT3, Q8C0T6, Q8C0X5	Gene names	Ankrd42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

ANR52_HUMAN
θ value	1.17247e-07 (rank : 66)	NC score	0.625236 (rank : 41)
Query Neighborhood Hits	371	Target Neighborhood Hits	322	Shared Neighborhood Hits	273
SwissProt Accessions	Q8NB46	Gene names	ANKRD52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ASB15_HUMAN
θ value	1.17247e-07 (rank : 67)	NC score	0.606768 (rank : 81)
Query Neighborhood Hits	371	Target Neighborhood Hits	305	Shared Neighborhood Hits	265
SwissProt Accessions	Q8WXK1	Gene names	ASB15
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 15 (ASB-15).

FANK1_MOUSE
θ value	1.17247e-07 (rank : 68)	NC score	0.637961 (rank : 10)
Query Neighborhood Hits	371	Target Neighborhood Hits	325	Shared Neighborhood Hits	264
SwissProt Accessions	Q9DAM9, Q9CUA7	Gene names	Fank1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains 1 protein (Germ cell- specific gene 1 protein) (GSG1).

ANK1_MOUSE
θ value	1.53129e-07 (rank : 69)	NC score	0.623149 (rank : 49)
Query Neighborhood Hits	371	Target Neighborhood Hits	430	Shared Neighborhood Hits	273
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

CENB2_HUMAN
θ value	1.99992e-07 (rank : 70)	NC score	0.446188 (rank : 234)
Query Neighborhood Hits	371	Target Neighborhood Hits	425	Shared Neighborhood Hits	250
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENB5_HUMAN
θ value	1.99992e-07 (rank : 71)	NC score	0.454440 (rank : 226)
Query Neighborhood Hits	371	Target Neighborhood Hits	395	Shared Neighborhood Hits	253
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

FANK1_HUMAN
θ value	1.99992e-07 (rank : 72)	NC score	0.638310 (rank : 9)
Query Neighborhood Hits	371	Target Neighborhood Hits	326	Shared Neighborhood Hits	265
SwissProt Accessions	Q8TC84, Q6UXY9, Q6X7T6	Gene names	FANK1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains protein 1.

ANKS3_HUMAN
θ value	2.61198e-07 (rank : 73)	NC score	0.624847 (rank : 44)
Query Neighborhood Hits	371	Target Neighborhood Hits	355	Shared Neighborhood Hits	262
SwissProt Accessions	Q6ZW76, Q8TF25	Gene names	ANKS3, KIAA1977
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 3.

ANKS3_MOUSE
θ value	3.41135e-07 (rank : 74)	NC score	0.628494 (rank : 30)
Query Neighborhood Hits	371	Target Neighborhood Hits	355	Shared Neighborhood Hits	262
SwissProt Accessions	Q9CZK6, Q6ZPF6, Q80X46	Gene names	Anks3, Kiaa1977
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 3.

CSKI1_HUMAN
θ value	3.41135e-07 (rank : 75)	NC score	0.588336 (rank : 111)
Query Neighborhood Hits	371	Target Neighborhood Hits	997	Shared Neighborhood Hits	277
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI1_MOUSE
θ value	3.41135e-07 (rank : 76)	NC score	0.587973 (rank : 114)
Query Neighborhood Hits	371	Target Neighborhood Hits	1031	Shared Neighborhood Hits	277
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

DAPK1_HUMAN
θ value	3.41135e-07 (rank : 77)	NC score	0.279181 (rank : 303)
Query Neighborhood Hits	371	Target Neighborhood Hits	1130	Shared Neighborhood Hits	273
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

ASB8_HUMAN
θ value	4.45536e-07 (rank : 78)	NC score	0.636380 (rank : 13)
Query Neighborhood Hits	371	Target Neighborhood Hits	294	Shared Neighborhood Hits	268
SwissProt Accessions	Q9H765, Q547Q2	Gene names	ASB8
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 8 (ASB-8).

ASB8_MOUSE
θ value	4.45536e-07 (rank : 79)	NC score	0.636411 (rank : 12)
Query Neighborhood Hits	371	Target Neighborhood Hits	293	Shared Neighborhood Hits	267
SwissProt Accessions	Q91ZT9, Q8R178	Gene names	Asb8
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 8 (ASB-8).

MIB2_MOUSE
θ value	4.45536e-07 (rank : 80)	NC score	0.608378 (rank : 78)
Query Neighborhood Hits	371	Target Neighborhood Hits	409	Shared Neighborhood Hits	268
SwissProt Accessions	Q8R516, Q52QU8, Q6PEF6, Q8C1N7, Q8VIB4	Gene names	Mib2, Skd
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) (Dystrophin-like protein) (Dyslike).

MIB2_HUMAN
θ value	5.81887e-07 (rank : 81)	NC score	0.610474 (rank : 72)
Query Neighborhood Hits	371	Target Neighborhood Hits	438	Shared Neighborhood Hits	271
SwissProt Accessions	Q96AX9, Q7Z437, Q8IY62, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1	Gene names	MIB2, SKD, ZZANK1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N).

RFXK_HUMAN
θ value	7.59969e-07 (rank : 82)	NC score	0.623866 (rank : 47)
Query Neighborhood Hits	371	Target Neighborhood Hits	282	Shared Neighborhood Hits	254
SwissProt Accessions	O14593, O95839	Gene names	RFXANK, ANKRA1, RFXB
Domain Architecture
Description	DNA-binding protein RFXANK (Regulatory factor X subunit B) (RFX-B) (Ankyrin repeat family A protein 1).

USH1G_HUMAN
θ value	7.59969e-07 (rank : 83)	NC score	0.606195 (rank : 82)
Query Neighborhood Hits	371	Target Neighborhood Hits	267	Shared Neighborhood Hits	253
SwissProt Accessions	Q495M9, Q8N251	Gene names	USH1G, SANS
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein (Scaffold protein containing ankyrin repeats and SAM domain).

USH1G_MOUSE
θ value	7.59969e-07 (rank : 84)	NC score	0.606174 (rank : 83)
Query Neighborhood Hits	371	Target Neighborhood Hits	271	Shared Neighborhood Hits	253
SwissProt Accessions	Q80T11, Q80UG0	Gene names	Ush1g, Sans
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein homolog (Scaffold protein containing ankyrin repeats and SAM domain) (Jackson shaker protein).

ZDH17_HUMAN
θ value	7.59969e-07 (rank : 85)	NC score	0.561685 (rank : 147)
Query Neighborhood Hits	371	Target Neighborhood Hits	334	Shared Neighborhood Hits	266
SwissProt Accessions	Q8IUH5, O75407, Q7Z2I0, Q86W89, Q86YK0, Q9P088, Q9UPZ8	Gene names	ZDHHC17, HIP14, HIP3, KIAA0946
Domain Architecture
Description	Palmitoyltransferase ZDHHC17 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 17) (DHHC-17) (Huntingtin-interacting protein 14) (Huntingtin-interacting protein 3) (Huntingtin-interacting protein HYPH) (Putative NF-kappa-B-activating protein 205) (Putative MAPK- activating protein PM11).

ZDH17_MOUSE
θ value	7.59969e-07 (rank : 86)	NC score	0.558339 (rank : 154)
Query Neighborhood Hits	371	Target Neighborhood Hits	328	Shared Neighborhood Hits	264
SwissProt Accessions	Q80TN5, Q8BJ08, Q8BYQ2, Q8BYQ6	Gene names	Zdhhc17, Hip14, Kiaa0946
Domain Architecture
Description	Palmitoyltransferase ZDHHC17 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 17) (DHHC-17) (Huntingtin-interacting protein 14).

ANKS6_MOUSE
θ value	9.92553e-07 (rank : 87)	NC score	0.621138 (rank : 56)
Query Neighborhood Hits	371	Target Neighborhood Hits	435	Shared Neighborhood Hits	268
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

RIPK4_HUMAN
θ value	9.92553e-07 (rank : 88)	NC score	0.398260 (rank : 247)
Query Neighborhood Hits	371	Target Neighborhood Hits	1094	Shared Neighborhood Hits	275
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

ANKK1_HUMAN
θ value	1.29631e-06 (rank : 89)	NC score	0.405057 (rank : 246)
Query Neighborhood Hits	371	Target Neighborhood Hits	1075	Shared Neighborhood Hits	273
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

ANKR5_MOUSE
θ value	1.29631e-06 (rank : 90)	NC score	0.625270 (rank : 40)
Query Neighborhood Hits	371	Target Neighborhood Hits	298	Shared Neighborhood Hits	265
SwissProt Accessions	Q9D2J7	Gene names	Ankrd5
Domain Architecture
Description	Ankyrin repeat domain-containing protein 5.

ANR29_HUMAN
θ value	1.29631e-06 (rank : 91)	NC score	0.650661 (rank : 6)
Query Neighborhood Hits	371	Target Neighborhood Hits	294	Shared Neighborhood Hits	271
SwissProt Accessions	Q8N6D5, Q6ZWE8, Q96LU9	Gene names	ANKRD29
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 29.

ASZ1_HUMAN
θ value	1.69304e-06 (rank : 92)	NC score	0.630554 (rank : 23)
Query Neighborhood Hits	371	Target Neighborhood Hits	341	Shared Neighborhood Hits	262
SwissProt Accessions	Q8WWH4	Gene names	ASZ1, GASZ
Domain Architecture
Description	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).

TRPA1_MOUSE
θ value	1.69304e-06 (rank : 93)	NC score	0.616361 (rank : 65)
Query Neighborhood Hits	371	Target Neighborhood Hits	343	Shared Neighborhood Hits	273
SwissProt Accessions	Q8BLA8	Gene names	Trpa1, Anktm1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1).

RN5A_MOUSE
θ value	2.88788e-06 (rank : 94)	NC score	0.560607 (rank : 149)
Query Neighborhood Hits	371	Target Neighborhood Hits	899	Shared Neighborhood Hits	269
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

TNI3K_MOUSE
θ value	2.88788e-06 (rank : 95)	NC score	0.317310 (rank : 287)
Query Neighborhood Hits	371	Target Neighborhood Hits	1079	Shared Neighborhood Hits	275
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

ANR15_HUMAN
θ value	3.77169e-06 (rank : 96)	NC score	0.561246 (rank : 148)
Query Neighborhood Hits	371	Target Neighborhood Hits	478	Shared Neighborhood Hits	259
SwissProt Accessions	Q14678, Q5W0W0, Q8IY65, Q8WX74	Gene names	ANKRD15, KANK, KIAA0172
Domain Architecture
Description	Ankyrin repeat domain-containing protein 15 (Kidney ankyrin repeat- containing protein).

ANRA2_HUMAN
θ value	3.77169e-06 (rank : 97)	NC score	0.623693 (rank : 48)
Query Neighborhood Hits	371	Target Neighborhood Hits	288	Shared Neighborhood Hits	260
SwissProt Accessions	Q9H9E1	Gene names	ANKRA2, ANKRA
Domain Architecture
Description	Ankyrin repeat family A protein 2 (RFXANK-like 2).

ASZ1_MOUSE
θ value	3.77169e-06 (rank : 98)	NC score	0.630199 (rank : 26)
Query Neighborhood Hits	371	Target Neighborhood Hits	319	Shared Neighborhood Hits	264
SwissProt Accessions	Q8VD46, Q9JKQ7	Gene names	Asz1, Gasz
Domain Architecture
Description	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).

RFXK_MOUSE
θ value	3.77169e-06 (rank : 99)	NC score	0.614392 (rank : 69)
Query Neighborhood Hits	371	Target Neighborhood Hits	273	Shared Neighborhood Hits	257
SwissProt Accessions	Q9Z205	Gene names	Rfxank, Rfxb, Tvl1
Domain Architecture
Description	DNA-binding protein RFXANK (Regulatory factor X subunit B) (RFX-B) (Regulatory factor X-associated ankyrin-containing protein) (Ankyrin repeat-containing adapter protein Tvl-1).

ABTB2_HUMAN
θ value	4.92598e-06 (rank : 100)	NC score	0.457351 (rank : 224)
Query Neighborhood Hits	371	Target Neighborhood Hits	391	Shared Neighborhood Hits	229
SwissProt Accessions	Q8N961, Q6MZW4, Q8NB44	Gene names	ABTB2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

ANR11_HUMAN
θ value	4.92598e-06 (rank : 101)	NC score	0.555894 (rank : 161)
Query Neighborhood Hits	371	Target Neighborhood Hits	1289	Shared Neighborhood Hits	274
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

ANRA2_MOUSE
θ value	4.92598e-06 (rank : 102)	NC score	0.623139 (rank : 50)
Query Neighborhood Hits	371	Target Neighborhood Hits	287	Shared Neighborhood Hits	260
SwissProt Accessions	Q99PE2	Gene names	Ankra2, Ankra
Domain Architecture
Description	Ankyrin repeat family A protein 2 (RFXANK-like 2).

ASB15_MOUSE
θ value	4.92598e-06 (rank : 103)	NC score	0.596564 (rank : 100)
Query Neighborhood Hits	371	Target Neighborhood Hits	292	Shared Neighborhood Hits	259
SwissProt Accessions	Q8VHS6	Gene names	Asb15
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 15 (ASB-15).

CSKI2_HUMAN
θ value	4.92598e-06 (rank : 104)	NC score	0.586322 (rank : 116)
Query Neighborhood Hits	371	Target Neighborhood Hits	747	Shared Neighborhood Hits	274
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

ILK_MOUSE
θ value	4.92598e-06 (rank : 105)	NC score	0.379379 (rank : 260)
Query Neighborhood Hits	371	Target Neighborhood Hits	858	Shared Neighborhood Hits	268
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

TNI3K_HUMAN
θ value	4.92598e-06 (rank : 106)	NC score	0.319773 (rank : 286)
Query Neighborhood Hits	371	Target Neighborhood Hits	1084	Shared Neighborhood Hits	274
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

ABTB2_MOUSE
θ value	6.43352e-06 (rank : 107)	NC score	0.448708 (rank : 231)
Query Neighborhood Hits	371	Target Neighborhood Hits	414	Shared Neighborhood Hits	227
SwissProt Accessions	Q7TQI7	Gene names	Abtb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

PA2G6_HUMAN
θ value	6.43352e-06 (rank : 108)	NC score	0.608732 (rank : 77)
Query Neighborhood Hits	371	Target Neighborhood Hits	284	Shared Neighborhood Hits	264
SwissProt Accessions	O60733, O75645, Q8N452, Q9UG29, Q9UIT0, Q9Y671	Gene names	PLA2G6, IPLA2
Domain Architecture
Description	85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4) (iPLA2) (CaI- PLA2) (Group VI phospholipase A2) (GVI PLA2).

CENB1_HUMAN
θ value	8.40245e-06 (rank : 109)	NC score	0.448654 (rank : 232)
Query Neighborhood Hits	371	Target Neighborhood Hits	383	Shared Neighborhood Hits	248
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

CSKI2_MOUSE
θ value	8.40245e-06 (rank : 110)	NC score	0.585653 (rank : 117)
Query Neighborhood Hits	371	Target Neighborhood Hits	812	Shared Neighborhood Hits	273
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

ILK1_HUMAN
θ value	8.40245e-06 (rank : 111)	NC score	0.379816 (rank : 259)
Query Neighborhood Hits	371	Target Neighborhood Hits	857	Shared Neighborhood Hits	267
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	8.40245e-06 (rank : 112)	NC score	0.393064 (rank : 251)
Query Neighborhood Hits	371	Target Neighborhood Hits	848	Shared Neighborhood Hits	267
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ANR41_HUMAN
θ value	1.09739e-05 (rank : 113)	NC score	0.593637 (rank : 105)
Query Neighborhood Hits	371	Target Neighborhood Hits	332	Shared Neighborhood Hits	244
SwissProt Accessions	Q8NAG6, Q8N8J8	Gene names	ANKRD41
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 41.

ASB14_MOUSE
θ value	1.09739e-05 (rank : 114)	NC score	0.600702 (rank : 92)
Query Neighborhood Hits	371	Target Neighborhood Hits	293	Shared Neighborhood Hits	260
SwissProt Accessions	Q8VHS7	Gene names	Asb14
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 14 (ASB-14).

BCOR_MOUSE
θ value	1.09739e-05 (rank : 115)	NC score	0.545020 (rank : 173)
Query Neighborhood Hits	371	Target Neighborhood Hits	521	Shared Neighborhood Hits	261
SwissProt Accessions	Q8CGN4, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3	Gene names	Bcor, Kiaa1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

RAI14_MOUSE
θ value	1.09739e-05 (rank : 116)	NC score	0.440922 (rank : 237)
Query Neighborhood Hits	371	Target Neighborhood Hits	1505	Shared Neighborhood Hits	278
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

ANKR6_HUMAN
θ value	1.43324e-05 (rank : 117)	NC score	0.636767 (rank : 11)
Query Neighborhood Hits	371	Target Neighborhood Hits	439	Shared Neighborhood Hits	274
SwissProt Accessions	Q9Y2G4, Q9NU24, Q9UFQ9	Gene names	ANKRD6, KIAA0957
Domain Architecture
Description	Ankyrin repeat domain-containing protein 6.

ASB1_MOUSE
θ value	1.43324e-05 (rank : 118)	NC score	0.591815 (rank : 109)
Query Neighborhood Hits	371	Target Neighborhood Hits	292	Shared Neighborhood Hits	257
SwissProt Accessions	Q9WV74	Gene names	Asb1
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 1 (ASB-1).

BCOR_HUMAN
θ value	1.43324e-05 (rank : 119)	NC score	0.537812 (rank : 177)
Query Neighborhood Hits	371	Target Neighborhood Hits	609	Shared Neighborhood Hits	261
SwissProt Accessions	Q6W2J9, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2	Gene names	BCOR, KIAA1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

ANKR1_HUMAN
θ value	1.87187e-05 (rank : 120)	NC score	0.628480 (rank : 31)
Query Neighborhood Hits	371	Target Neighborhood Hits	308	Shared Neighborhood Hits	266
SwissProt Accessions	Q15327, Q96LE7	Gene names	ANKRD1, C193, CARP, HA1A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) (Cytokine-inducible nuclear protein) (C-193).

ANKR2_MOUSE
θ value	1.87187e-05 (rank : 121)	NC score	0.635785 (rank : 14)
Query Neighborhood Hits	371	Target Neighborhood Hits	312	Shared Neighborhood Hits	270
SwissProt Accessions	Q9WV06	Gene names	Ankrd2, Arpp
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (mArpp).

ANKS1_HUMAN
θ value	1.87187e-05 (rank : 122)	NC score	0.600449 (rank : 93)
Query Neighborhood Hits	371	Target Neighborhood Hits	438	Shared Neighborhood Hits	271
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

ANR10_HUMAN
θ value	1.87187e-05 (rank : 123)	NC score	0.610359 (rank : 74)
Query Neighborhood Hits	371	Target Neighborhood Hits	289	Shared Neighborhood Hits	257
SwissProt Accessions	Q9NXR5	Gene names	ANKRD10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

ANR10_MOUSE
θ value	1.87187e-05 (rank : 124)	NC score	0.609810 (rank : 75)
Query Neighborhood Hits	371	Target Neighborhood Hits	273	Shared Neighborhood Hits	256
SwissProt Accessions	Q99LW0	Gene names	Ankrd10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

ASB10_MOUSE
θ value	1.87187e-05 (rank : 125)	NC score	0.625459 (rank : 39)
Query Neighborhood Hits	371	Target Neighborhood Hits	301	Shared Neighborhood Hits	270
SwissProt Accessions	Q91ZT7	Gene names	Asb10
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

MYPT2_HUMAN
θ value	1.87187e-05 (rank : 126)	NC score	0.603620 (rank : 89)
Query Neighborhood Hits	371	Target Neighborhood Hits	707	Shared Neighborhood Hits	274
SwissProt Accessions	O60237, Q8N179, Q9HCB7, Q9HCB8	Gene names	PPP1R12B, MYPT2
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase- targeting subunit 2) (Myosin phosphatase target subunit 2).

ANFY1_HUMAN
θ value	2.44474e-05 (rank : 127)	NC score	0.551349 (rank : 168)
Query Neighborhood Hits	371	Target Neighborhood Hits	480	Shared Neighborhood Hits	271
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANKR1_MOUSE
θ value	2.44474e-05 (rank : 128)	NC score	0.624853 (rank : 43)
Query Neighborhood Hits	371	Target Neighborhood Hits	316	Shared Neighborhood Hits	271
SwissProt Accessions	Q9CR42, O55014, Q3UIF7, Q3UJ39, Q792Q9	Gene names	Ankrd1, Carp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein).

ANKR2_HUMAN
θ value	2.44474e-05 (rank : 129)	NC score	0.632456 (rank : 20)
Query Neighborhood Hits	371	Target Neighborhood Hits	321	Shared Neighborhood Hits	270
SwissProt Accessions	Q9GZV1, Q5T456, Q8WUD7	Gene names	ANKRD2, ARPP
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp).

ANR12_HUMAN
θ value	2.44474e-05 (rank : 130)	NC score	0.536108 (rank : 178)
Query Neighborhood Hits	371	Target Neighborhood Hits	1081	Shared Neighborhood Hits	273
SwissProt Accessions	Q6UB98, O94951, Q658K1, Q6QMF7, Q9H231, Q9H784	Gene names	ANKRD12, ANCO2, KIAA0874
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein).

BARD1_HUMAN
θ value	2.44474e-05 (rank : 131)	NC score	0.599539 (rank : 95)
Query Neighborhood Hits	371	Target Neighborhood Hits	427	Shared Neighborhood Hits	268
SwissProt Accessions	Q99728, O43574	Gene names	BARD1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

EHMT1_HUMAN
θ value	2.44474e-05 (rank : 132)	NC score	0.588081 (rank : 113)
Query Neighborhood Hits	371	Target Neighborhood Hits	417	Shared Neighborhood Hits	270
SwissProt Accessions	Q9H9B1, Q8TCN7, Q96F53, Q96JF1, Q96KH4	Gene names	EHMT1, EUHMTASE1, KIAA1876
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a- like protein 1) (GLP1).

GABP2_HUMAN
θ value	2.44474e-05 (rank : 133)	NC score	0.628982 (rank : 28)
Query Neighborhood Hits	371	Target Neighborhood Hits	454	Shared Neighborhood Hits	269
SwissProt Accessions	Q06547, Q06545, Q12940, Q12941, Q12942, Q8IYD0	Gene names	GABPB2, E4TF1B, GABPB, GABPB1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1) (Transcription factor E4TF1-53) (Transcription factor E4TF1-47) (Nuclear respiratory factor 2).

ASB1_HUMAN
θ value	3.19293e-05 (rank : 134)	NC score	0.593580 (rank : 106)
Query Neighborhood Hits	371	Target Neighborhood Hits	291	Shared Neighborhood Hits	259
SwissProt Accessions	Q9Y576, Q9ULS4	Gene names	ASB1, KIAA1146
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 1 (ASB-1).

DDEF1_MOUSE
θ value	3.19293e-05 (rank : 135)	NC score	0.270640 (rank : 306)
Query Neighborhood Hits	371	Target Neighborhood Hits	592	Shared Neighborhood Hits	192
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

GABP2_MOUSE
θ value	3.19293e-05 (rank : 136)	NC score	0.630512 (rank : 24)
Query Neighborhood Hits	371	Target Neighborhood Hits	429	Shared Neighborhood Hits	269
SwissProt Accessions	Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2	Gene names	Gabpb2, Gabpb, Gabpb1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1).

HECD3_MOUSE
θ value	3.19293e-05 (rank : 137)	NC score	0.459911 (rank : 222)
Query Neighborhood Hits	371	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

OSTF1_MOUSE
θ value	3.19293e-05 (rank : 138)	NC score	0.491562 (rank : 204)
Query Neighborhood Hits	371	Target Neighborhood Hits	467	Shared Neighborhood Hits	244
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

ANKR5_HUMAN
θ value	4.1701e-05 (rank : 139)	NC score	0.618175 (rank : 61)
Query Neighborhood Hits	371	Target Neighborhood Hits	297	Shared Neighborhood Hits	265
SwissProt Accessions	Q9NU02, Q9H6Y9	Gene names	ANKRD5
Domain Architecture
Description	Ankyrin repeat domain-containing protein 5.

BARD1_MOUSE
θ value	4.1701e-05 (rank : 140)	NC score	0.596089 (rank : 102)
Query Neighborhood Hits	371	Target Neighborhood Hits	411	Shared Neighborhood Hits	265
SwissProt Accessions	O70445	Gene names	Bard1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

EHMT2_HUMAN
θ value	4.1701e-05 (rank : 141)	NC score	0.580843 (rank : 121)
Query Neighborhood Hits	371	Target Neighborhood Hits	498	Shared Neighborhood Hits	272
SwissProt Accessions	Q96KQ7, Q14349, Q6PK06, Q96MH5, Q96QD0, Q9UQL8, Q9Y331	Gene names	EHMT2, BAT8, G9A, NG36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

RAI14_HUMAN
θ value	4.1701e-05 (rank : 142)	NC score	0.465355 (rank : 218)
Query Neighborhood Hits	371	Target Neighborhood Hits	1367	Shared Neighborhood Hits	277
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

ZDH13_MOUSE
θ value	4.1701e-05 (rank : 143)	NC score	0.551625 (rank : 167)
Query Neighborhood Hits	371	Target Neighborhood Hits	329	Shared Neighborhood Hits	269
SwissProt Accessions	Q9CWU2, Q3UK32, Q3UKV1	Gene names	Zdhhc13, Hip14l
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC13 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein).

ANKK1_MOUSE
θ value	5.44631e-05 (rank : 144)	NC score	0.390969 (rank : 253)
Query Neighborhood Hits	371	Target Neighborhood Hits	1072	Shared Neighborhood Hits	274
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

ASB10_HUMAN
θ value	5.44631e-05 (rank : 145)	NC score	0.626032 (rank : 36)
Query Neighborhood Hits	371	Target Neighborhood Hits	291	Shared Neighborhood Hits	269
SwissProt Accessions	Q8WXI3	Gene names	ASB10
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

ASB7_HUMAN
θ value	5.44631e-05 (rank : 146)	NC score	0.622103 (rank : 53)
Query Neighborhood Hits	371	Target Neighborhood Hits	296	Shared Neighborhood Hits	268
SwissProt Accessions	Q9H672, Q7Z4S3	Gene names	ASB7
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 7 (ASB-7).

ASB7_MOUSE
θ value	5.44631e-05 (rank : 147)	NC score	0.622453 (rank : 52)
Query Neighborhood Hits	371	Target Neighborhood Hits	296	Shared Neighborhood Hits	268
SwissProt Accessions	Q91ZU0	Gene names	Asb7
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 7 (ASB-7).

DGKI_HUMAN
θ value	5.44631e-05 (rank : 148)	NC score	0.294650 (rank : 295)
Query Neighborhood Hits	371	Target Neighborhood Hits	609	Shared Neighborhood Hits	210
SwissProt Accessions	O75912, Q9NZ49	Gene names	DGKI
Domain Architecture
Description	Diacylglycerol kinase iota (EC 2.7.1.107) (Diglyceride kinase iota) (DGK-iota) (DAG kinase iota).

ASB3_HUMAN
θ value	7.1131e-05 (rank : 149)	NC score	0.626363 (rank : 35)
Query Neighborhood Hits	371	Target Neighborhood Hits	316	Shared Neighborhood Hits	270
SwissProt Accessions	Q9Y575, Q9NVZ2	Gene names	ASB3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

ASB3_MOUSE
θ value	7.1131e-05 (rank : 150)	NC score	0.628250 (rank : 32)
Query Neighborhood Hits	371	Target Neighborhood Hits	316	Shared Neighborhood Hits	270
SwissProt Accessions	Q9WV72	Gene names	Asb3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

CD2A1_MOUSE
θ value	7.1131e-05 (rank : 151)	NC score	0.552646 (rank : 166)
Query Neighborhood Hits	371	Target Neighborhood Hits	206	Shared Neighborhood Hits	199
SwissProt Accessions	P51480, O89088, P97510, P97937, Q6PEA2, Q78E39, Q78E57, Q792X7, Q9QWH6, Q9QWH7, Q9QWH8	Gene names	Cdkn2a, P16ink4a
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 2A, isoforms 1/2 (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4) (p16-INK4a).

INVS_MOUSE
θ value	7.1131e-05 (rank : 152)	NC score	0.619491 (rank : 60)
Query Neighborhood Hits	371	Target Neighborhood Hits	609	Shared Neighborhood Hits	272
SwissProt Accessions	O89019, O88849	Gene names	Invs, Inv, Nphp2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning protein) (Nephrocystin-2).

ZDH13_HUMAN
θ value	7.1131e-05 (rank : 153)	NC score	0.554190 (rank : 163)
Query Neighborhood Hits	371	Target Neighborhood Hits	322	Shared Neighborhood Hits	268
SwissProt Accessions	Q8IUH4, Q7Z2D3, Q86VK2, Q9NV30, Q9NV99	Gene names	ZDHHC13, HIP14L, HIP3RP
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC13 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein) (Huntingtin- interacting protein HIP3RP) (Putative NF-kappa-B-activating protein 209) (Putative MAPK-activating protein PM03).

CLPB_MOUSE
θ value	9.29e-05 (rank : 154)	NC score	0.519992 (rank : 184)
Query Neighborhood Hits	371	Target Neighborhood Hits	289	Shared Neighborhood Hits	237
SwissProt Accessions	Q60649	Gene names	Clpb, Skd3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

EHMT2_MOUSE
θ value	9.29e-05 (rank : 155)	NC score	0.570778 (rank : 134)
Query Neighborhood Hits	371	Target Neighborhood Hits	750	Shared Neighborhood Hits	277
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

HECD3_HUMAN
θ value	9.29e-05 (rank : 156)	NC score	0.456308 (rank : 225)
Query Neighborhood Hits	371	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

INVS_HUMAN
θ value	9.29e-05 (rank : 157)	NC score	0.621722 (rank : 54)
Query Neighborhood Hits	371	Target Neighborhood Hits	455	Shared Neighborhood Hits	271
SwissProt Accessions	Q9Y283, Q5W0T6, Q8IVX8, Q9BRB9, Q9Y488, Q9Y498	Gene names	INVS, INV, NPHP2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning homolog) (Nephrocystin-2).

PA2G6_MOUSE
θ value	9.29e-05 (rank : 158)	NC score	0.611233 (rank : 71)
Query Neighborhood Hits	371	Target Neighborhood Hits	293	Shared Neighborhood Hits	268
SwissProt Accessions	P97819, Q99LA9, Q9JK61	Gene names	Pla2g6
Domain Architecture
Description	85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4) (iPLA2) (CaI- PLA2) (Group VI phospholipase A2) (GVI PLA2).

ANFY1_MOUSE
θ value	0.000121331 (rank : 159)	NC score	0.550306 (rank : 169)
Query Neighborhood Hits	371	Target Neighborhood Hits	480	Shared Neighborhood Hits	273
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

GABP3_MOUSE
θ value	0.000121331 (rank : 160)	NC score	0.628698 (rank : 29)
Query Neighborhood Hits	371	Target Neighborhood Hits	330	Shared Neighborhood Hits	263
SwissProt Accessions	P81069	Gene names	Gabpb2
Domain Architecture	No domain graphic available
Description	GA-binding protein beta-2-1 chain (GABP subunit beta-2-1) (GABPB2-1).

OSTF1_HUMAN
θ value	0.000121331 (rank : 161)	NC score	0.474751 (rank : 214)
Query Neighborhood Hits	371	Target Neighborhood Hits	466	Shared Neighborhood Hits	243
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

ANR23_MOUSE
θ value	0.000158464 (rank : 162)	NC score	0.630858 (rank : 22)
Query Neighborhood Hits	371	Target Neighborhood Hits	296	Shared Neighborhood Hits	268
SwissProt Accessions	Q812A3	Gene names	Ankrd23, Darp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein).

BCL3_MOUSE
θ value	0.000158464 (rank : 163)	NC score	0.604078 (rank : 87)
Query Neighborhood Hits	371	Target Neighborhood Hits	388	Shared Neighborhood Hits	268
SwissProt Accessions	Q9Z2F6	Gene names	Bcl3
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 3-encoded protein homolog (Protein Bcl-3).

KRIT1_MOUSE
θ value	0.000158464 (rank : 164)	NC score	0.521614 (rank : 183)
Query Neighborhood Hits	371	Target Neighborhood Hits	258	Shared Neighborhood Hits	225
SwissProt Accessions	Q6S5J6, Q6VSV2, Q7TPR8, Q8C9Q6, Q9EPY2, Q9ERH0	Gene names	Krit1, Ccm1
Domain Architecture	No domain graphic available
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog).

MPP8_HUMAN
θ value	0.000158464 (rank : 165)	NC score	0.498425 (rank : 199)
Query Neighborhood Hits	371	Target Neighborhood Hits	948	Shared Neighborhood Hits	251
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

RN5A_HUMAN
θ value	0.000158464 (rank : 166)	NC score	0.594239 (rank : 104)
Query Neighborhood Hits	371	Target Neighborhood Hits	608	Shared Neighborhood Hits	268
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

UACA_HUMAN
θ value	0.000158464 (rank : 167)	NC score	0.364309 (rank : 267)
Query Neighborhood Hits	371	Target Neighborhood Hits	1622	Shared Neighborhood Hits	277
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

ANKY2_HUMAN
θ value	0.00020696 (rank : 168)	NC score	0.574158 (rank : 130)
Query Neighborhood Hits	371	Target Neighborhood Hits	306	Shared Neighborhood Hits	249
SwissProt Accessions	Q8IV38, Q96BL3	Gene names	ANKMY2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and MYND domain-containing protein 2.

ASB2_HUMAN
θ value	0.00020696 (rank : 169)	NC score	0.616996 (rank : 64)
Query Neighborhood Hits	371	Target Neighborhood Hits	309	Shared Neighborhood Hits	269
SwissProt Accessions	Q96Q27, Q9NSU5, Q9Y567	Gene names	ASB2
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 2 (ASB-2).

ASB4_MOUSE
θ value	0.00020696 (rank : 170)	NC score	0.573486 (rank : 131)
Query Neighborhood Hits	371	Target Neighborhood Hits	265	Shared Neighborhood Hits	251
SwissProt Accessions	Q9WV71	Gene names	Asb4
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 4 (ASB-4).

FKBP3_HUMAN
θ value	0.00020696 (rank : 171)	NC score	0.067762 (rank : 371)
Query Neighborhood Hits	371	Target Neighborhood Hits	35	Shared Neighborhood Hits	4
SwissProt Accessions	Q00688, Q14317	Gene names	FKBP3, FKBP25
Domain Architecture
Description	FK506-binding protein 3 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) (25 kDa FKBP) (FKBP-25) (Rapamycin- selective 25 kDa immunophilin).

KRIT1_HUMAN
θ value	0.00020696 (rank : 172)	NC score	0.509615 (rank : 193)
Query Neighborhood Hits	371	Target Neighborhood Hits	258	Shared Neighborhood Hits	216
SwissProt Accessions	O00522, O43894, Q506L6, Q6U276, Q75N19, Q9H180, Q9H264, Q9HAX5	Gene names	KRIT1, CCM1
Domain Architecture
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein).

ANKS1_MOUSE
θ value	0.000270298 (rank : 173)	NC score	0.588914 (rank : 110)
Query Neighborhood Hits	371	Target Neighborhood Hits	453	Shared Neighborhood Hits	270
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

ASB13_MOUSE
θ value	0.000270298 (rank : 174)	NC score	0.603811 (rank : 88)
Query Neighborhood Hits	371	Target Neighborhood Hits	293	Shared Neighborhood Hits	263
SwissProt Accessions	Q8VBX0	Gene names	Asb13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 13 (ASB-13).

CDN2D_HUMAN
θ value	0.000270298 (rank : 175)	NC score	0.620182 (rank : 58)
Query Neighborhood Hits	371	Target Neighborhood Hits	268	Shared Neighborhood Hits	255
SwissProt Accessions	P55273, Q13102, Q6FGE9	Gene names	CDKN2D
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

DDFL1_HUMAN
θ value	0.000270298 (rank : 176)	NC score	0.332781 (rank : 279)
Query Neighborhood Hits	371	Target Neighborhood Hits	353	Shared Neighborhood Hits	224
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

ANKR9_MOUSE
θ value	0.00035302 (rank : 177)	NC score	0.279971 (rank : 302)
Query Neighborhood Hits	371	Target Neighborhood Hits	120	Shared Neighborhood Hits	115
SwissProt Accessions	Q8BH83, Q3TA09, Q8BHR3	Gene names	Ankrd9
Domain Architecture
Description	Ankyrin repeat domain-containing protein 9.

ASB13_HUMAN
θ value	0.00035302 (rank : 178)	NC score	0.603183 (rank : 90)
Query Neighborhood Hits	371	Target Neighborhood Hits	293	Shared Neighborhood Hits	264
SwissProt Accessions	Q8WXK3, Q96EP7, Q9H8Z1	Gene names	ASB13
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 13 (ASB-13).

ASB4_HUMAN
θ value	0.00035302 (rank : 179)	NC score	0.572915 (rank : 132)
Query Neighborhood Hits	371	Target Neighborhood Hits	264	Shared Neighborhood Hits	251
SwissProt Accessions	Q9Y574, O14586	Gene names	ASB4
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 4 (ASB-4).

BCL3_HUMAN
θ value	0.00035302 (rank : 180)	NC score	0.604611 (rank : 84)
Query Neighborhood Hits	371	Target Neighborhood Hits	324	Shared Neighborhood Hits	267
SwissProt Accessions	P20749	Gene names	BCL3
Domain Architecture
Description	B-cell lymphoma 3-encoded protein (Protein Bcl-3).

CTTB2_HUMAN
θ value	0.00035302 (rank : 181)	NC score	0.540455 (rank : 176)
Query Neighborhood Hits	371	Target Neighborhood Hits	1061	Shared Neighborhood Hits	277
SwissProt Accessions	Q8WZ74, O43389, Q7LG11, Q9C0A5	Gene names	CTTNBP2, C7orf8, CORTBP2, KIAA1758
Domain Architecture	No domain graphic available
Description	Cortactin-binding protein 2 (CortBP2).

GIT2_MOUSE
θ value	0.00035302 (rank : 182)	NC score	0.427980 (rank : 238)
Query Neighborhood Hits	371	Target Neighborhood Hits	323	Shared Neighborhood Hits	249
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

ANKY2_MOUSE
θ value	0.000461057 (rank : 183)	NC score	0.556501 (rank : 160)
Query Neighborhood Hits	371	Target Neighborhood Hits	316	Shared Neighborhood Hits	248
SwissProt Accessions	Q3TPE9, Q8BK14, Q8BYW5, Q8R3N4, Q921J1	Gene names	Ankmy2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and MYND domain-containing protein 2.

ANR26_MOUSE
θ value	0.000461057 (rank : 184)	NC score	0.330307 (rank : 282)
Query Neighborhood Hits	371	Target Neighborhood Hits	1554	Shared Neighborhood Hits	272
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

IKBB_HUMAN
θ value	0.000461057 (rank : 185)	NC score	0.563667 (rank : 143)
Query Neighborhood Hits	371	Target Neighborhood Hits	284	Shared Neighborhood Hits	261
SwissProt Accessions	Q15653, Q96BJ7	Gene names	NFKBIB, IKBB, TRIP9
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9).

OSBL1_HUMAN
θ value	0.000461057 (rank : 186)	NC score	0.493646 (rank : 203)
Query Neighborhood Hits	371	Target Neighborhood Hits	368	Shared Neighborhood Hits	267
SwissProt Accessions	Q9BXW6, Q9BZF5, Q9NW87	Gene names	OSBPL1A, ORP1, OSBP8, OSBPL1
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

PP16B_HUMAN
θ value	0.000461057 (rank : 187)	NC score	0.600035 (rank : 94)
Query Neighborhood Hits	371	Target Neighborhood Hits	307	Shared Neighborhood Hits	268
SwissProt Accessions	Q96T49, O94912, Q9NQG4	Gene names	PPP1R16B, ANKRD4, KIAA0823
Domain Architecture
Description	Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein) (hTIMAP) (CAAX box protein TIMAP) (Ankyrin repeat domain protein 4).

TRPA1_HUMAN
θ value	0.000461057 (rank : 188)	NC score	0.609028 (rank : 76)
Query Neighborhood Hits	371	Target Neighborhood Hits	339	Shared Neighborhood Hits	271
SwissProt Accessions	O75762	Gene names	TRPA1, ANKTM1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation sensitive-protein p120).

CDN2D_MOUSE
θ value	0.000602161 (rank : 189)	NC score	0.614072 (rank : 70)
Query Neighborhood Hits	371	Target Neighborhood Hits	267	Shared Neighborhood Hits	252
SwissProt Accessions	Q60773, Q60794	Gene names	Cdkn2d
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

FKBP3_MOUSE
θ value	0.000602161 (rank : 190)	NC score	0.064620 (rank : 380)
Query Neighborhood Hits	371	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	Q62446, Q9WTJ7	Gene names	Fkbp3, Fkbp25
Domain Architecture
Description	FK506-binding protein 3 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) (25 kDa FKBP) (FKBP-25) (Rapamycin- selective 25 kDa immunophilin).

OSBL1_MOUSE
θ value	0.000602161 (rank : 191)	NC score	0.484797 (rank : 207)
Query Neighborhood Hits	371	Target Neighborhood Hits	336	Shared Neighborhood Hits	268
SwissProt Accessions	Q91XL9, O88318, Q3TH97, Q673L8, Q6DFU6	Gene names	Osbpl1a, Orp1, Orp1a
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

ANR23_HUMAN
θ value	0.000786445 (rank : 192)	NC score	0.627410 (rank : 33)
Query Neighborhood Hits	371	Target Neighborhood Hits	291	Shared Neighborhood Hits	269
SwissProt Accessions	Q86SG2, Q711K7, Q8NAJ7	Gene names	ANKRD23, DARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein) (Muscle ankyrin repeat protein 3).

ASB2_MOUSE
θ value	0.000786445 (rank : 193)	NC score	0.610458 (rank : 73)
Query Neighborhood Hits	371	Target Neighborhood Hits	321	Shared Neighborhood Hits	268
SwissProt Accessions	Q8K0L0, Q9CTH4, Q9WV73	Gene names	Asb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 2 (ASB-2).

IKBA_MOUSE
θ value	0.000786445 (rank : 194)	NC score	0.575062 (rank : 129)
Query Neighborhood Hits	371	Target Neighborhood Hits	283	Shared Neighborhood Hits	258
SwissProt Accessions	Q9Z1E3, Q80ZX5	Gene names	Nfkbia, Ikba
Domain Architecture	No domain graphic available
Description	NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkappaBalpha) (IKB- alpha).

MTPN_HUMAN
θ value	0.000786445 (rank : 195)	NC score	0.630468 (rank : 25)
Query Neighborhood Hits	371	Target Neighborhood Hits	269	Shared Neighborhood Hits	259
SwissProt Accessions	P58546	Gene names	MTPN
Domain Architecture
Description	Myotrophin (Protein V-1).

MTPN_MOUSE
θ value	0.000786445 (rank : 196)	NC score	0.632187 (rank : 21)
Query Neighborhood Hits	371	Target Neighborhood Hits	269	Shared Neighborhood Hits	259
SwissProt Accessions	P62774, P80144, Q543M6, Q9DCN8	Gene names	Mtpn, Gcdp
Domain Architecture	No domain graphic available
Description	Myotrophin (Protein V-1) (Granule cell differentiation protein).

ANR16_HUMAN
θ value	0.00134147 (rank : 197)	NC score	0.625836 (rank : 37)
Query Neighborhood Hits	371	Target Neighborhood Hits	286	Shared Neighborhood Hits	266
SwissProt Accessions	Q6P6B7, Q9NT01	Gene names	ANKRD16
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 16.

ANR47_MOUSE
θ value	0.00134147 (rank : 198)	NC score	0.546727 (rank : 172)
Query Neighborhood Hits	371	Target Neighborhood Hits	350	Shared Neighborhood Hits	251
SwissProt Accessions	Q9Z1P7	Gene names	Ankrd47, D17Ertd288e, Ng28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

GIT1_HUMAN
θ value	0.00134147 (rank : 199)	NC score	0.410951 (rank : 243)
Query Neighborhood Hits	371	Target Neighborhood Hits	336	Shared Neighborhood Hits	242
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

GIT1_MOUSE
θ value	0.00134147 (rank : 200)	NC score	0.413497 (rank : 241)
Query Neighborhood Hits	371	Target Neighborhood Hits	341	Shared Neighborhood Hits	243
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

UACA_MOUSE
θ value	0.00134147 (rank : 201)	NC score	0.343611 (rank : 273)
Query Neighborhood Hits	371	Target Neighborhood Hits	1620	Shared Neighborhood Hits	281
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

ANR25_HUMAN
θ value	0.00175202 (rank : 202)	NC score	0.507518 (rank : 195)
Query Neighborhood Hits	371	Target Neighborhood Hits	350	Shared Neighborhood Hits	242
SwissProt Accessions	Q63ZY3, Q3KQZ3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210	Gene names	ANKRD25, KIAA1518, SIP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25 (SRC-1-interacting protein) (SRC1-interacting protein).

ANR46_HUMAN
θ value	0.00175202 (rank : 203)	NC score	0.614971 (rank : 66)
Query Neighborhood Hits	371	Target Neighborhood Hits	281	Shared Neighborhood Hits	258
SwissProt Accessions	Q86W74, Q6P9B7	Gene names	ANKRD46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

DDEF2_HUMAN
θ value	0.00175202 (rank : 204)	NC score	0.339571 (rank : 275)
Query Neighborhood Hits	371	Target Neighborhood Hits	599	Shared Neighborhood Hits	229
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	0.00175202 (rank : 205)	NC score	0.337886 (rank : 276)
Query Neighborhood Hits	371	Target Neighborhood Hits	625	Shared Neighborhood Hits	232
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DGKZ_HUMAN
θ value	0.00175202 (rank : 206)	NC score	0.310468 (rank : 288)
Query Neighborhood Hits	371	Target Neighborhood Hits	551	Shared Neighborhood Hits	215
SwissProt Accessions	Q13574, O00542	Gene names	DGKZ, DAGK6
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

GIT2_HUMAN
θ value	0.00175202 (rank : 207)	NC score	0.394338 (rank : 250)
Query Neighborhood Hits	371	Target Neighborhood Hits	381	Shared Neighborhood Hits	243
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

IKBB_MOUSE
θ value	0.00175202 (rank : 208)	NC score	0.566736 (rank : 137)
Query Neighborhood Hits	371	Target Neighborhood Hits	284	Shared Neighborhood Hits	263
SwissProt Accessions	Q60778, Q9D6L5	Gene names	Nfkbib, Ikbb
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B).

PP16B_MOUSE
θ value	0.00175202 (rank : 209)	NC score	0.598111 (rank : 97)
Query Neighborhood Hits	371	Target Neighborhood Hits	302	Shared Neighborhood Hits	268
SwissProt Accessions	Q8VHQ3	Gene names	Ppp1r16b
Domain Architecture
Description	Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein) (CAAX box protein TIMAP).

ANKR9_HUMAN
θ value	0.00228821 (rank : 210)	NC score	0.244642 (rank : 309)
Query Neighborhood Hits	371	Target Neighborhood Hits	99	Shared Neighborhood Hits	96
SwissProt Accessions	Q96BM1	Gene names	ANKRD9
Domain Architecture
Description	Ankyrin repeat domain-containing protein 9.

ANR25_MOUSE
θ value	0.00228821 (rank : 211)	NC score	0.495524 (rank : 201)
Query Neighborhood Hits	371	Target Neighborhood Hits	398	Shared Neighborhood Hits	241
SwissProt Accessions	Q8BX02, Q8BLD5, Q91Z35	Gene names	Ankrd25
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25.

ANR46_MOUSE
θ value	0.00228821 (rank : 212)	NC score	0.614742 (rank : 68)
Query Neighborhood Hits	371	Target Neighborhood Hits	274	Shared Neighborhood Hits	253
SwissProt Accessions	Q8BTZ5, Q1LZK9, Q8BV97	Gene names	Ankrd46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

CDN2B_HUMAN
θ value	0.00228821 (rank : 213)	NC score	0.495016 (rank : 202)
Query Neighborhood Hits	371	Target Neighborhood Hits	196	Shared Neighborhood Hits	190
SwissProt Accessions	P42772, Q6FI09	Gene names	CDKN2B, MTS2
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b) (p15INK4B) (Multiple tumor suppressor 2) (MTS2).

IKBA_HUMAN
θ value	0.00228821 (rank : 214)	NC score	0.585041 (rank : 118)
Query Neighborhood Hits	371	Target Neighborhood Hits	280	Shared Neighborhood Hits	258
SwissProt Accessions	P25963	Gene names	NFKBIA, IKBA, MAD3, NFKBI
Domain Architecture
Description	NF-kappa-B inhibitor alpha (Major histocompatibility complex enhancer- binding protein MAD3) (I-kappa-B-alpha) (IkappaBalpha) (IKB-alpha).

POT14_HUMAN
θ value	0.00228821 (rank : 215)	NC score	0.509523 (rank : 194)
Query Neighborhood Hits	371	Target Neighborhood Hits	403	Shared Neighborhood Hits	257
SwissProt Accessions	Q6S5H5, Q6S5H6, Q6S8J2	Gene names	POTE14
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 14.

POT22_HUMAN
θ value	0.00228821 (rank : 216)	NC score	0.486619 (rank : 206)
Query Neighborhood Hits	371	Target Neighborhood Hits	266	Shared Neighborhood Hits	247
SwissProt Accessions	Q6S545	Gene names	ACTBL1, POTE22
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 22.

PP16A_MOUSE
θ value	0.00228821 (rank : 217)	NC score	0.604433 (rank : 86)
Query Neighborhood Hits	371	Target Neighborhood Hits	318	Shared Neighborhood Hits	270
SwissProt Accessions	Q923M0, Q4V9Z1	Gene names	Ppp1r16a, Mypt3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase targeting subunit 3).

TEX14_HUMAN
θ value	0.00298849 (rank : 218)	NC score	0.299707 (rank : 293)
Query Neighborhood Hits	371	Target Neighborhood Hits	1103	Shared Neighborhood Hits	238
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

ASB12_MOUSE
θ value	0.00390308 (rank : 219)	NC score	0.580200 (rank : 122)
Query Neighborhood Hits	371	Target Neighborhood Hits	261	Shared Neighborhood Hits	251
SwissProt Accessions	Q9D738	Gene names	Asb12
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 12 (ASB-12).

DGKZ_MOUSE
θ value	0.00390308 (rank : 220)	NC score	0.287468 (rank : 299)
Query Neighborhood Hits	371	Target Neighborhood Hits	542	Shared Neighborhood Hits	196
SwissProt Accessions	Q80UP3	Gene names	Dgkz
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

AN36A_HUMAN
θ value	0.00509761 (rank : 221)	NC score	0.553246 (rank : 164)
Query Neighborhood Hits	371	Target Neighborhood Hits	271	Shared Neighborhood Hits	256
SwissProt Accessions	Q6UX02, Q86X62	Gene names	ANKRD36, ANKRD36A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 36A.

ANR47_HUMAN
θ value	0.00509761 (rank : 222)	NC score	0.523173 (rank : 182)
Query Neighborhood Hits	371	Target Neighborhood Hits	369	Shared Neighborhood Hits	246
SwissProt Accessions	Q6NY19, Q6NZI1, Q6ZQR3, Q8IUV2	Gene names	ANKRD47
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

ASB11_MOUSE
θ value	0.00509761 (rank : 223)	NC score	0.570226 (rank : 135)
Query Neighborhood Hits	371	Target Neighborhood Hits	271	Shared Neighborhood Hits	249
SwissProt Accessions	Q9CQ31, Q3UJ13, Q9D0V1	Gene names	Asb11
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 11 (ASB-11).

ASPP2_HUMAN
θ value	0.00509761 (rank : 224)	NC score	0.412440 (rank : 242)
Query Neighborhood Hits	371	Target Neighborhood Hits	1156	Shared Neighborhood Hits	266
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

CDN2C_HUMAN
θ value	0.00509761 (rank : 225)	NC score	0.621226 (rank : 55)
Query Neighborhood Hits	371	Target Neighborhood Hits	262	Shared Neighborhood Hits	253
SwissProt Accessions	P42773, Q8TB83	Gene names	CDKN2C, CDKN6
Domain Architecture
Description	Cyclin-dependent kinase 6 inhibitor (p18-INK6) (Cyclin-dependent kinase 4 inhibitor C) (p18-INK4c).

CT086_HUMAN
θ value	0.00509761 (rank : 226)	NC score	0.624889 (rank : 42)
Query Neighborhood Hits	371	Target Neighborhood Hits	277	Shared Neighborhood Hits	258
SwissProt Accessions	Q9BZ19, Q4VXE6	Gene names	C20orf86
Domain Architecture
Description	Putative uncharacterized protein C20orf86.

CLPB_HUMAN
θ value	0.00665767 (rank : 227)	NC score	0.454358 (rank : 227)
Query Neighborhood Hits	371	Target Neighborhood Hits	265	Shared Neighborhood Hits	223
SwissProt Accessions	Q9H078, Q8ND11, Q9H8Y0	Gene names	CLPB, SKD3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

ANR32_HUMAN
θ value	0.00869519 (rank : 228)	NC score	0.557196 (rank : 156)
Query Neighborhood Hits	371	Target Neighborhood Hits	270	Shared Neighborhood Hits	250
SwissProt Accessions	Q9BQI6	Gene names	ANKRD32
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 32.

ASB16_HUMAN
θ value	0.00869519 (rank : 229)	NC score	0.594990 (rank : 103)
Query Neighborhood Hits	371	Target Neighborhood Hits	286	Shared Neighborhood Hits	259
SwissProt Accessions	Q96NS5, Q8WXK0	Gene names	ASB16
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 16 (ASB-16).

DDFL1_MOUSE
θ value	0.00869519 (rank : 230)	NC score	0.393042 (rank : 252)
Query Neighborhood Hits	371	Target Neighborhood Hits	324	Shared Neighborhood Hits	240
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

SNCAP_HUMAN
θ value	0.00869519 (rank : 231)	NC score	0.523613 (rank : 180)
Query Neighborhood Hits	371	Target Neighborhood Hits	313	Shared Neighborhood Hits	232
SwissProt Accessions	Q9Y6H5	Gene names	SNCAIP
Domain Architecture
Description	Synphilin-1 (Alpha-synuclein-interacting protein).

ANR26_HUMAN
θ value	0.0113563 (rank : 232)	NC score	0.308844 (rank : 289)
Query Neighborhood Hits	371	Target Neighborhood Hits	1614	Shared Neighborhood Hits	275
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

ANR42_HUMAN
θ value	0.0113563 (rank : 233)	NC score	0.622685 (rank : 51)
Query Neighborhood Hits	371	Target Neighborhood Hits	284	Shared Neighborhood Hits	264
SwissProt Accessions	Q8N9B4, Q49A49	Gene names	ANKRD42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

PP16A_HUMAN
θ value	0.0113563 (rank : 234)	NC score	0.596294 (rank : 101)
Query Neighborhood Hits	371	Target Neighborhood Hits	340	Shared Neighborhood Hits	265
SwissProt Accessions	Q96I34	Gene names	PPP1R16A, MYPT3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase- targeting subunit 3).

AN36B_HUMAN
θ value	0.0148317 (rank : 235)	NC score	0.571359 (rank : 133)
Query Neighborhood Hits	371	Target Neighborhood Hits	294	Shared Neighborhood Hits	262
SwissProt Accessions	Q8N2N9, Q6IPR0	Gene names	ANKRD36B
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 36B.

ASB16_MOUSE
θ value	0.0148317 (rank : 236)	NC score	0.599289 (rank : 96)
Query Neighborhood Hits	371	Target Neighborhood Hits	306	Shared Neighborhood Hits	265
SwissProt Accessions	Q8VHS5, Q8BYT0	Gene names	Asb16
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 16 (ASB-16).

LRRK2_MOUSE
θ value	0.0148317 (rank : 237)	NC score	0.016246 (rank : 446)
Query Neighborhood Hits	371	Target Neighborhood Hits	1359	Shared Neighborhood Hits	38
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

SHAN1_HUMAN
θ value	0.0148317 (rank : 238)	NC score	0.510905 (rank : 192)
Query Neighborhood Hits	371	Target Neighborhood Hits	1041	Shared Neighborhood Hits	265
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

AN30A_HUMAN
θ value	0.0193708 (rank : 239)	NC score	0.407023 (rank : 245)
Query Neighborhood Hits	371	Target Neighborhood Hits	1119	Shared Neighborhood Hits	264
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

CD2A1_HUMAN
θ value	0.0193708 (rank : 240)	NC score	0.488532 (rank : 205)
Query Neighborhood Hits	371	Target Neighborhood Hits	196	Shared Neighborhood Hits	188
SwissProt Accessions	P42771, O95440, Q15191, Q5VVJ5, Q96B52, Q9NP05	Gene names	CDKN2A, CDKN2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4) (p16-INK4a) (p16INK4A) (Multiple tumor suppressor 1) (MTS1).

IKBE_MOUSE
θ value	0.0193708 (rank : 241)	NC score	0.575264 (rank : 128)
Query Neighborhood Hits	371	Target Neighborhood Hits	308	Shared Neighborhood Hits	260
SwissProt Accessions	O54910, Q3U686, Q9CZZ9, Q9D7U3	Gene names	Nfkbie, Ikbe
Domain Architecture
Description	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKB-E).

ANR21_HUMAN
θ value	0.0252991 (rank : 242)	NC score	0.512728 (rank : 190)
Query Neighborhood Hits	371	Target Neighborhood Hits	864	Shared Neighborhood Hits	273
SwissProt Accessions	Q86YR6	Gene names	ANKRD21, POTE
Domain Architecture
Description	Ankyrin repeat domain-containing protein 21 (Protein POTE) (Prostate, ovary, testis-expressed protein).

CLR59_HUMAN
θ value	0.0252991 (rank : 243)	NC score	0.239488 (rank : 310)
Query Neighborhood Hits	371	Target Neighborhood Hits	163	Shared Neighborhood Hits	140
SwissProt Accessions	Q96DZ5, Q8WWL1, Q96C99, Q9UFT7	Gene names	CLIPR59
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 170-related 59 kDa protein (CLIPR-59) (CLIP-170-related 59 kDa protein).

POT15_HUMAN
θ value	0.0252991 (rank : 244)	NC score	0.512559 (rank : 191)
Query Neighborhood Hits	371	Target Neighborhood Hits	893	Shared Neighborhood Hits	273
SwissProt Accessions	Q6S5H4, Q6NXN7, Q6S5H7	Gene names	POTE15
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 15.

A20A2_HUMAN
θ value	0.0330416 (rank : 245)	NC score	0.467534 (rank : 216)
Query Neighborhood Hits	371	Target Neighborhood Hits	716	Shared Neighborhood Hits	264
SwissProt Accessions	Q4UJ75	Gene names	ANKRD20A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A2.

ANR19_HUMAN
θ value	0.0330416 (rank : 246)	NC score	0.547313 (rank : 170)
Query Neighborhood Hits	371	Target Neighborhood Hits	276	Shared Neighborhood Hits	260
SwissProt Accessions	Q9H560	Gene names	ANKRD19
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 19.

ASB11_HUMAN
θ value	0.0330416 (rank : 247)	NC score	0.568233 (rank : 136)
Query Neighborhood Hits	371	Target Neighborhood Hits	271	Shared Neighborhood Hits	249
SwissProt Accessions	Q8WXH4, Q3SYC4	Gene names	ASB11
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 11 (ASB-11).

ASB12_HUMAN
θ value	0.0330416 (rank : 248)	NC score	0.576769 (rank : 126)
Query Neighborhood Hits	371	Target Neighborhood Hits	263	Shared Neighborhood Hits	252
SwissProt Accessions	Q8WXK4, Q52LK4, Q6ISF9	Gene names	ASB12
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 12 (ASB-12).

GLSL_MOUSE
θ value	0.0330416 (rank : 249)	NC score	0.382306 (rank : 258)
Query Neighborhood Hits	371	Target Neighborhood Hits	212	Shared Neighborhood Hits	194
SwissProt Accessions	Q571F8	Gene names	Gls2, Kiaa4146
Domain Architecture	No domain graphic available
Description	Glutaminase liver isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (L-glutaminase).

GRIN1_MOUSE
θ value	0.0330416 (rank : 250)	NC score	0.037507 (rank : 418)
Query Neighborhood Hits	371	Target Neighborhood Hits	337	Shared Neighborhood Hits	12
SwissProt Accessions	Q3UNH4, Q6PGF9, Q9QZY2	Gene names	Gprin1
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

IKBE_HUMAN
θ value	0.0431538 (rank : 251)	NC score	0.562051 (rank : 146)
Query Neighborhood Hits	371	Target Neighborhood Hits	288	Shared Neighborhood Hits	256
SwissProt Accessions	O00221	Gene names	NFKBIE, IKBE
Domain Architecture
Description	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKBE).

GLSK_HUMAN
θ value	0.0563607 (rank : 252)	NC score	0.365646 (rank : 266)
Query Neighborhood Hits	371	Target Neighborhood Hits	204	Shared Neighborhood Hits	182
SwissProt Accessions	O94925, Q9UL05, Q9UL06, Q9UL07, Q9UN40	Gene names	GLS, GLS1, KIAA0838
Domain Architecture
Description	Glutaminase kidney isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (K-glutaminase).

GLSL_HUMAN
θ value	0.0563607 (rank : 253)	NC score	0.387979 (rank : 255)
Query Neighborhood Hits	371	Target Neighborhood Hits	211	Shared Neighborhood Hits	194
SwissProt Accessions	Q9UI32, Q9NYY2, Q9UI31	Gene names	GLS2, GA
Domain Architecture
Description	Glutaminase liver isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (L-glutaminase).

TRPV6_MOUSE
θ value	0.0563607 (rank : 254)	NC score	0.376735 (rank : 261)
Query Neighborhood Hits	371	Target Neighborhood Hits	284	Shared Neighborhood Hits	241
SwissProt Accessions	Q91WD2	Gene names	Trpv6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1).

A20A3_HUMAN
θ value	0.0736092 (rank : 255)	NC score	0.468271 (rank : 215)
Query Neighborhood Hits	371	Target Neighborhood Hits	692	Shared Neighborhood Hits	264
SwissProt Accessions	Q5VUR7	Gene names	ANKRD20A3
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A3.

A20A4_HUMAN
θ value	0.0736092 (rank : 256)	NC score	0.464949 (rank : 219)
Query Neighborhood Hits	371	Target Neighborhood Hits	710	Shared Neighborhood Hits	264
SwissProt Accessions	Q5SQ80	Gene names	ANKRD20A4
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A4.

CDN2B_MOUSE
θ value	0.0736092 (rank : 257)	NC score	0.504054 (rank : 196)
Query Neighborhood Hits	371	Target Neighborhood Hits	201	Shared Neighborhood Hits	190
SwissProt Accessions	P55271	Gene names	Cdkn2b
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b).

CDN2C_MOUSE
θ value	0.0736092 (rank : 258)	NC score	0.614767 (rank : 67)
Query Neighborhood Hits	371	Target Neighborhood Hits	270	Shared Neighborhood Hits	256
SwissProt Accessions	Q60772	Gene names	Cdkn2c
Domain Architecture
Description	Cyclin-dependent kinase 6 inhibitor (p18-INK6) (Cyclin-dependent kinase 4 inhibitor C) (p18-INK4c).

TEX14_MOUSE
θ value	0.0736092 (rank : 259)	NC score	0.297022 (rank : 294)
Query Neighborhood Hits	371	Target Neighborhood Hits	1333	Shared Neighborhood Hits	252
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TRPV5_MOUSE
θ value	0.0736092 (rank : 260)	NC score	0.342449 (rank : 274)
Query Neighborhood Hits	371	Target Neighborhood Hits	278	Shared Neighborhood Hits	235
SwissProt Accessions	P69744	Gene names	Trpv5
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC1) (Calcium transport protein 2) (CaT2).

A20A1_HUMAN
θ value	0.0961366 (rank : 261)	NC score	0.466874 (rank : 217)
Query Neighborhood Hits	371	Target Neighborhood Hits	698	Shared Neighborhood Hits	264
SwissProt Accessions	Q5TYW2, Q9H0H6	Gene names	ANKRD20A1, ANKRD20A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A1.

AN13A_MOUSE
θ value	0.0961366 (rank : 262)	NC score	0.307825 (rank : 291)
Query Neighborhood Hits	371	Target Neighborhood Hits	226	Shared Neighborhood Hits	209
SwissProt Accessions	Q80UP5, Q2VPQ7, Q6P7F2	Gene names	Ankrd13a, Ankrd13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13A.

ANR40_HUMAN
θ value	0.0961366 (rank : 263)	NC score	0.452419 (rank : 228)
Query Neighborhood Hits	371	Target Neighborhood Hits	224	Shared Neighborhood Hits	195
SwissProt Accessions	Q6AI12, Q96E32	Gene names	ANKRD40
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 40.

ASB6_MOUSE
θ value	0.0961366 (rank : 264)	NC score	0.515750 (rank : 187)
Query Neighborhood Hits	371	Target Neighborhood Hits	264	Shared Neighborhood Hits	234
SwissProt Accessions	Q91ZU1, Q8VEC6	Gene names	Asb6
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 6 (ASB-6).

NFKB1_HUMAN
θ value	0.0961366 (rank : 265)	NC score	0.501713 (rank : 198)
Query Neighborhood Hits	371	Target Neighborhood Hits	306	Shared Neighborhood Hits	263
SwissProt Accessions	P19838, Q68D84, Q86V43, Q8N4X7, Q9NZC0	Gene names	NFKB1
Domain Architecture
Description	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) [Contains: Nuclear factor NF-kappa-B p50 subunit].

SYNG_HUMAN
θ value	0.0961366 (rank : 266)	NC score	0.030219 (rank : 421)
Query Neighborhood Hits	371	Target Neighborhood Hits	160	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UMZ2, Q6ZT17	Gene names	AP1GBP1, SYNG
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

ASB9_HUMAN
θ value	0.125558 (rank : 267)	NC score	0.565493 (rank : 139)
Query Neighborhood Hits	371	Target Neighborhood Hits	267	Shared Neighborhood Hits	248
SwissProt Accessions	Q96DX5, Q9NWS5, Q9Y4T3	Gene names	ASB9
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 9 (ASB-9).

GNPTA_HUMAN
θ value	0.125558 (rank : 268)	NC score	0.075588 (rank : 355)
Query Neighborhood Hits	371	Target Neighborhood Hits	43	Shared Neighborhood Hits	10
SwissProt Accessions	Q3T906, Q3ZQK2, Q6IPW5, Q86TQ2, Q96N13, Q9ULL2	Gene names	GNPTAB, GNPTA, KIAA1208
Domain Architecture	No domain graphic available
Description	N-acetylglucosamine-1-phosphotransferase subunits alpha/beta precursor (EC 2.7.8.17) (GlcNAc-1-phosphotransferase alpha/beta subunits) (UDP- N-acetylglucosamine-1-phosphotransferase alpha/beta subunits) (Stealth protein GNPTAB) [Contains: N-acetylglucosamine-1-phosphotransferase subunit alpha; N-acetylglucosamine-1-phosphotransferase subunit beta].

NFKB1_MOUSE
θ value	0.125558 (rank : 269)	NC score	0.502765 (rank : 197)
Query Neighborhood Hits	371	Target Neighborhood Hits	300	Shared Neighborhood Hits	256
SwissProt Accessions	P25799, Q3TZE8, Q3V2V6, Q6TDG8, Q75ZL1, Q80Y21, Q8C712	Gene names	Nfkb1
Domain Architecture
Description	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) (NF-kappa-B1 p84/NF-kappa-B1 p98) [Contains: Nuclear factor NF- kappa-B p50 subunit].

AN13A_HUMAN
θ value	0.163984 (rank : 270)	NC score	0.324724 (rank : 284)
Query Neighborhood Hits	371	Target Neighborhood Hits	243	Shared Neighborhood Hits	213
SwissProt Accessions	Q8IZ07, O60736	Gene names	ANKRD13A, ANKRD13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13A (Protein KE03).

ANR38_HUMAN
θ value	0.163984 (rank : 271)	NC score	0.480508 (rank : 211)
Query Neighborhood Hits	371	Target Neighborhood Hits	443	Shared Neighborhood Hits	227
SwissProt Accessions	Q5T7N3, Q6P9A0, Q86T71, Q86VE6, Q8NAX3	Gene names	ANKRD38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

GIDRP_MOUSE
θ value	0.163984 (rank : 272)	NC score	0.034275 (rank : 419)
Query Neighborhood Hits	371	Target Neighborhood Hits	96	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BJM3, Q3UGJ8, Q5U5U8	Gene names	Gidrp88, D19Ertd386e
Domain Architecture	No domain graphic available
Description	Growth inhibition and differentiation-related protein 88 homolog.

POTE8_HUMAN
θ value	0.163984 (rank : 273)	NC score	0.542661 (rank : 175)
Query Neighborhood Hits	371	Target Neighborhood Hits	337	Shared Neighborhood Hits	268
SwissProt Accessions	Q6S8J7, Q6S8J6	Gene names	POTE8
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 8.

ASB9_MOUSE
θ value	0.21417 (rank : 274)	NC score	0.557389 (rank : 155)
Query Neighborhood Hits	371	Target Neighborhood Hits	257	Shared Neighborhood Hits	242
SwissProt Accessions	Q91ZT8, Q9DAF7	Gene names	Asb9
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 9 (ASB-9).

NFKB2_HUMAN
θ value	0.279714 (rank : 275)	NC score	0.498231 (rank : 200)
Query Neighborhood Hits	371	Target Neighborhood Hits	325	Shared Neighborhood Hits	263
SwissProt Accessions	Q00653, Q04860, Q9BU75, Q9H471, Q9H472	Gene names	NFKB2, LYT10
Domain Architecture
Description	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10) (Oncogene Lyt-10) (Lyt10) [Contains: Nuclear factor NF-kappa-B p52 subunit].

ANKR7_HUMAN
θ value	0.365318 (rank : 276)	NC score	0.578547 (rank : 125)
Query Neighborhood Hits	371	Target Neighborhood Hits	286	Shared Neighborhood Hits	260
SwissProt Accessions	Q92527, Q96QN1, Q9UDM3	Gene names	ANKRD7
Domain Architecture
Description	Ankyrin repeat domain-containing protein 7 (Testis-specific protein TSA806).

ANR32_MOUSE
θ value	0.365318 (rank : 277)	NC score	0.546890 (rank : 171)
Query Neighborhood Hits	371	Target Neighborhood Hits	285	Shared Neighborhood Hits	250
SwissProt Accessions	Q8R3P9, Q5XK30, Q8BHY5, Q921Y9	Gene names	Ankrd32
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 32.

ANR37_HUMAN
θ value	0.365318 (rank : 278)	NC score	0.544080 (rank : 174)
Query Neighborhood Hits	371	Target Neighborhood Hits	247	Shared Neighborhood Hits	239
SwissProt Accessions	Q7Z713	Gene names	ANKRD37, LPR2BP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37 (Low-density lipoprotein receptor-related protein 2-binding protein) (hLrp2bp).

ANR40_MOUSE
θ value	0.365318 (rank : 279)	NC score	0.443733 (rank : 235)
Query Neighborhood Hits	371	Target Neighborhood Hits	228	Shared Neighborhood Hits	198
SwissProt Accessions	Q5SUE8, Q8R595, Q9CU71	Gene names	Ankrd40
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 40.

ANR43_HUMAN
θ value	0.365318 (rank : 280)	NC score	0.449484 (rank : 229)
Query Neighborhood Hits	371	Target Neighborhood Hits	209	Shared Neighborhood Hits	198
SwissProt Accessions	Q2M3V2, Q8NAE7	Gene names	ANKRD43
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 43.

ANR49_MOUSE
θ value	0.365318 (rank : 281)	NC score	0.604610 (rank : 85)
Query Neighborhood Hits	371	Target Neighborhood Hits	285	Shared Neighborhood Hits	263
SwissProt Accessions	Q8VE42, Q9Z2S1	Gene names	Ankrd49, Fgif, Gbif
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor) (Fetal globin-increasing factor).

ANR22_HUMAN
θ value	0.47712 (rank : 282)	NC score	0.576679 (rank : 127)
Query Neighborhood Hits	371	Target Neighborhood Hits	243	Shared Neighborhood Hits	230
SwissProt Accessions	Q5VYY1, Q8WU06	Gene names	ANKRD22
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 22.

ASPP1_HUMAN
θ value	0.47712 (rank : 283)	NC score	0.395632 (rank : 248)
Query Neighborhood Hits	371	Target Neighborhood Hits	956	Shared Neighborhood Hits	260
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_MOUSE
θ value	0.47712 (rank : 284)	NC score	0.387873 (rank : 256)
Query Neighborhood Hits	371	Target Neighborhood Hits	1244	Shared Neighborhood Hits	265
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

LRRK2_HUMAN
θ value	0.47712 (rank : 285)	NC score	0.012455 (rank : 449)
Query Neighborhood Hits	371	Target Neighborhood Hits	1382	Shared Neighborhood Hits	30
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

TMF1_HUMAN
θ value	0.47712 (rank : 286)	NC score	0.023833 (rank : 428)
Query Neighborhood Hits	371	Target Neighborhood Hits	987	Shared Neighborhood Hits	29
SwissProt Accessions	P82094	Gene names	TMF1
Domain Architecture	No domain graphic available
Description	TATA element modulatory factor (TMF).

ALS2_HUMAN
θ value	0.62314 (rank : 287)	NC score	0.057122 (rank : 392)
Query Neighborhood Hits	371	Target Neighborhood Hits	121	Shared Neighborhood Hits	8
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

CENG1_HUMAN
θ value	0.62314 (rank : 288)	NC score	0.280401 (rank : 301)
Query Neighborhood Hits	371	Target Neighborhood Hits	544	Shared Neighborhood Hits	233
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

CENG1_MOUSE
θ value	0.62314 (rank : 289)	NC score	0.280432 (rank : 300)
Query Neighborhood Hits	371	Target Neighborhood Hits	531	Shared Neighborhood Hits	231
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

CENG2_HUMAN
θ value	0.62314 (rank : 290)	NC score	0.278712 (rank : 304)
Query Neighborhood Hits	371	Target Neighborhood Hits	471	Shared Neighborhood Hits	244
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

K1333_HUMAN
θ value	0.62314 (rank : 291)	NC score	0.045949 (rank : 416)
Query Neighborhood Hits	371	Target Neighborhood Hits	50	Shared Neighborhood Hits	9
SwissProt Accessions	Q7L622, Q9BVR2, Q9H9E9, Q9NXC0, Q9P2L3	Gene names	KIAA1333
Domain Architecture	No domain graphic available
Description	Protein KIAA1333 (EC 6.3.2.-).

K1333_MOUSE
θ value	0.62314 (rank : 292)	NC score	0.066018 (rank : 376)
Query Neighborhood Hits	371	Target Neighborhood Hits	53	Shared Neighborhood Hits	13
SwissProt Accessions	Q5RJY2, Q6ZPT7, Q8BNA4	Gene names	Kiaa1333
Domain Architecture	No domain graphic available
Description	Protein KIAA1333 (EC 6.3.2.-).

SYYM_MOUSE
θ value	0.62314 (rank : 293)	NC score	0.025961 (rank : 426)
Query Neighborhood Hits	371	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BYL4, Q6PAH7	Gene names	Yars2
Domain Architecture	No domain graphic available
Description	Tyrosyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.1) (Tyrosine--tRNA ligase) (TyrRS).

TRAK1_HUMAN
θ value	0.62314 (rank : 294)	NC score	0.023732 (rank : 430)
Query Neighborhood Hits	371	Target Neighborhood Hits	660	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UPV9, Q96B69	Gene names	TRAK1, KIAA1042, OIP106
Domain Architecture	No domain graphic available
Description	Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase- interacting protein).

ANR49_HUMAN
θ value	0.813845 (rank : 295)	NC score	0.601942 (rank : 91)
Query Neighborhood Hits	371	Target Neighborhood Hits	282	Shared Neighborhood Hits	264
SwissProt Accessions	Q8WVL7, Q8NDF2, Q96JE5, Q9NXK7	Gene names	ANKRD49, FGIF
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor).

ASB6_HUMAN
θ value	0.813845 (rank : 296)	NC score	0.513012 (rank : 189)
Query Neighborhood Hits	371	Target Neighborhood Hits	256	Shared Neighborhood Hits	234
SwissProt Accessions	Q9NWX5	Gene names	ASB6
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 6 (ASB-6).

RAPSN_HUMAN
θ value	0.813845 (rank : 297)	NC score	0.027090 (rank : 423)
Query Neighborhood Hits	371	Target Neighborhood Hits	84	Shared Neighborhood Hits	5
SwissProt Accessions	Q13702, Q9BTD9	Gene names	RAPSN
Domain Architecture
Description	43 kDa receptor-associated protein of the synapse (RAPsyn) (Acetylcholine receptor-associated 43 kDa protein) (43 kDa postsynaptic protein).

CENG2_MOUSE
θ value	1.06291 (rank : 298)	NC score	0.277410 (rank : 305)
Query Neighborhood Hits	371	Target Neighborhood Hits	463	Shared Neighborhood Hits	242
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

ANR43_MOUSE
θ value	1.38821 (rank : 299)	NC score	0.442976 (rank : 236)
Query Neighborhood Hits	371	Target Neighborhood Hits	214	Shared Neighborhood Hits	201
SwissProt Accessions	Q8BLS7	Gene names	Ankrd43
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 43.

K1958_HUMAN
θ value	1.38821 (rank : 300)	NC score	0.019735 (rank : 442)
Query Neighborhood Hits	371	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N8K9, Q5T252, Q8TF43, Q96N02	Gene names	KIAA1958
Domain Architecture	No domain graphic available
Description	Protein KIAA1958.

REST_MOUSE
θ value	1.38821 (rank : 301)	NC score	0.022712 (rank : 433)
Query Neighborhood Hits	371	Target Neighborhood Hits	1506	Shared Neighborhood Hits	52
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

TPP2_HUMAN
θ value	1.38821 (rank : 302)	NC score	0.026790 (rank : 424)
Query Neighborhood Hits	371	Target Neighborhood Hits	30	Shared Neighborhood Hits	6
SwissProt Accessions	P29144	Gene names	TPP2
Domain Architecture
Description	Tripeptidyl-peptidase 2 (EC 3.4.14.10) (Tripeptidyl-peptidase II) (TPP-II) (Tripeptidyl aminopeptidase).

TPP2_MOUSE
θ value	1.38821 (rank : 303)	NC score	0.027298 (rank : 422)
Query Neighborhood Hits	371	Target Neighborhood Hits	24	Shared Neighborhood Hits	6
SwissProt Accessions	Q64514	Gene names	Tpp2
Domain Architecture
Description	Tripeptidyl-peptidase 2 (EC 3.4.14.10) (Tripeptidyl-peptidase II) (TPP-II) (Tripeptidyl aminopeptidase).

NFKB2_MOUSE
θ value	1.81305 (rank : 304)	NC score	0.480080 (rank : 212)
Query Neighborhood Hits	371	Target Neighborhood Hits	326	Shared Neighborhood Hits	259
SwissProt Accessions	Q9WTK5	Gene names	Nfkb2
Domain Architecture
Description	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) [Contains: Nuclear factor NF-kappa-B p52 subunit].

RAPSN_MOUSE
θ value	1.81305 (rank : 305)	NC score	0.024331 (rank : 427)
Query Neighborhood Hits	371	Target Neighborhood Hits	92	Shared Neighborhood Hits	5
SwissProt Accessions	P12672	Gene names	Rapsn
Domain Architecture
Description	43 kDa receptor-associated protein of the synapse (RAPsyn) (Acetylcholine receptor-associated 43 kDa protein) (43 kDa postsynaptic protein).

RSNL2_MOUSE
θ value	1.81305 (rank : 306)	NC score	0.161758 (rank : 324)
Query Neighborhood Hits	371	Target Neighborhood Hits	129	Shared Neighborhood Hits	96
SwissProt Accessions	Q8CI96, Q8BW09, Q921Q4, Q9D2S6	Gene names	Rsnl2
Domain Architecture	No domain graphic available
Description	Restin-like protein 2.

WAPL_HUMAN
θ value	1.81305 (rank : 307)	NC score	0.021176 (rank : 437)
Query Neighborhood Hits	371	Target Neighborhood Hits	122	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z5K2, Q5VSK5, Q8IX10, Q92549	Gene names	WAPAL, FOE, KIAA0261, WAPL
Domain Architecture	No domain graphic available
Description	Wings apart-like protein homolog (Friend of EBNA2 protein).

ZN638_HUMAN
θ value	1.81305 (rank : 308)	NC score	0.019949 (rank : 441)
Query Neighborhood Hits	371	Target Neighborhood Hits	343	Shared Neighborhood Hits	14
SwissProt Accessions	Q14966, Q53R34, Q5XJ05, Q68DP3, Q6P2H2, Q7Z3T7, Q8NF92, Q8TCA1, Q9H2G1, Q9NP37	Gene names	ZNF638, NP220, ZFML
Domain Architecture	No domain graphic available
Description	Zinc finger protein 638 (Nuclear protein 220) (Zinc-finger matrin-like protein) (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL tumor antigen se33-1).

AMPH_MOUSE
θ value	2.36792 (rank : 309)	NC score	0.020609 (rank : 439)
Query Neighborhood Hits	371	Target Neighborhood Hits	291	Shared Neighborhood Hits	14
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

ANR37_MOUSE
θ value	2.36792 (rank : 310)	NC score	0.514075 (rank : 188)
Query Neighborhood Hits	371	Target Neighborhood Hits	237	Shared Neighborhood Hits	229
SwissProt Accessions	Q569N2, Q8CHS0	Gene names	Ankrd37
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37.

BMS1_HUMAN
θ value	2.36792 (rank : 311)	NC score	0.020892 (rank : 438)
Query Neighborhood Hits	371	Target Neighborhood Hits	109	Shared Neighborhood Hits	4
SwissProt Accessions	Q14692, Q86XJ9	Gene names	BMS1L, KIAA0187
Domain Architecture
Description	Ribosome biogenesis protein BMS1 homolog.

CCD46_HUMAN
θ value	2.36792 (rank : 312)	NC score	0.016587 (rank : 445)
Query Neighborhood Hits	371	Target Neighborhood Hits	1430	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

GAB1_HUMAN
θ value	2.36792 (rank : 313)	NC score	0.018058 (rank : 443)
Query Neighborhood Hits	371	Target Neighborhood Hits	279	Shared Neighborhood Hits	12
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

K0141_MOUSE
θ value	2.36792 (rank : 314)	NC score	0.022690 (rank : 434)
Query Neighborhood Hits	371	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q9DCV6, Q6A0B8	Gene names	Kiaa0141
Domain Architecture
Description	Protein KIAA0141.

K0319_HUMAN
θ value	2.36792 (rank : 315)	NC score	0.016185 (rank : 447)
Query Neighborhood Hits	371	Target Neighborhood Hits	154	Shared Neighborhood Hits	7
SwissProt Accessions	Q5VV43, Q9UJC8, Q9Y4G7	Gene names	KIAA0319
Domain Architecture	No domain graphic available
Description	Protein KIAA0319 precursor.

MARK2_HUMAN
θ value	2.36792 (rank : 316)	NC score	0.006103 (rank : 457)
Query Neighborhood Hits	371	Target Neighborhood Hits	1056	Shared Neighborhood Hits	31
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

RBM25_HUMAN
θ value	2.36792 (rank : 317)	NC score	0.020487 (rank : 440)
Query Neighborhood Hits	371	Target Neighborhood Hits	682	Shared Neighborhood Hits	23
SwissProt Accessions	P49756, Q9UEQ5, Q9UIE9	Gene names	RBM25, RNPC7
Domain Architecture	No domain graphic available
Description	Probable RNA-binding protein 25 (RNA-binding motif protein 25) (RNA- binding region-containing protein 7) (Protein S164).

RSNL2_HUMAN
θ value	2.36792 (rank : 318)	NC score	0.180158 (rank : 319)
Query Neighborhood Hits	371	Target Neighborhood Hits	136	Shared Neighborhood Hits	113
SwissProt Accessions	Q8N3C7, Q7Z4U3, Q96BR7, Q96MA5, Q9H7C0	Gene names	RSNL2
Domain Architecture	No domain graphic available
Description	Restin-like protein 2.

TOP2A_MOUSE
θ value	2.36792 (rank : 319)	NC score	0.011990 (rank : 450)
Query Neighborhood Hits	371	Target Neighborhood Hits	101	Shared Neighborhood Hits	6
SwissProt Accessions	Q01320	Gene names	Top2a, Top-2, Top2
Domain Architecture
Description	DNA topoisomerase 2-alpha (EC 5.99.1.3) (DNA topoisomerase II, alpha isozyme).

VATH_HUMAN
θ value	2.36792 (rank : 320)	NC score	0.023078 (rank : 432)
Query Neighborhood Hits	371	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UI12, Q6PK44, Q9H3E3, Q9Y300	Gene names	ATP6V1H
Domain Architecture
Description	Vacuolar ATP synthase subunit H (EC 3.6.3.14) (V-ATPase H subunit) (Vacuolar proton pump subunit H) (V-ATPase 50/57 kDa subunits) (Vacuolar proton pump subunit SFD) (VMA13) (Nef-binding protein 1) (NBP1).

VATH_MOUSE
θ value	2.36792 (rank : 321)	NC score	0.023117 (rank : 431)
Query Neighborhood Hits	371	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BVE3, Q921X8	Gene names	Atp6v1h
Domain Architecture	No domain graphic available
Description	Vacuolar ATP synthase subunit H (EC 3.6.3.14) (V-ATPase H subunit) (Vacuolar proton pump subunit H).

ZN644_HUMAN
θ value	2.36792 (rank : 322)	NC score	-0.006355 (rank : 475)
Query Neighborhood Hits	371	Target Neighborhood Hits	704	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H582, Q5TCC0, Q6BEP7, Q6P446, Q6PI06, Q7LG67, Q9ULJ9	Gene names	ZNF644, KIAA1221, ZEP2
Domain Architecture	No domain graphic available
Description	Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2).

ANR18_HUMAN
θ value	3.0926 (rank : 323)	NC score	0.426719 (rank : 239)
Query Neighborhood Hits	371	Target Neighborhood Hits	1106	Shared Neighborhood Hits	266
SwissProt Accessions	Q8IVF6, Q7Z468	Gene names	ANKRD18A, KIAA2015
Domain Architecture
Description	Ankyrin repeat domain-containing protein 18A.

ASB5_MOUSE
θ value	3.0926 (rank : 324)	NC score	0.553073 (rank : 165)
Query Neighborhood Hits	371	Target Neighborhood Hits	266	Shared Neighborhood Hits	248
SwissProt Accessions	Q9D1A4	Gene names	Asb5
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 5 (ASB-5).

CENG3_HUMAN
θ value	3.0926 (rank : 325)	NC score	0.254322 (rank : 307)
Query Neighborhood Hits	371	Target Neighborhood Hits	455	Shared Neighborhood Hits	225
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_MOUSE
θ value	3.0926 (rank : 326)	NC score	0.254320 (rank : 308)
Query Neighborhood Hits	371	Target Neighborhood Hits	467	Shared Neighborhood Hits	225
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

NUD12_HUMAN
θ value	3.0926 (rank : 327)	NC score	0.389370 (rank : 254)
Query Neighborhood Hits	371	Target Neighborhood Hits	222	Shared Neighborhood Hits	193
SwissProt Accessions	Q9BQG2, Q8TAL7	Gene names	NUDT12
Domain Architecture	No domain graphic available
Description	Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12).

NUD12_MOUSE
θ value	3.0926 (rank : 328)	NC score	0.416104 (rank : 240)
Query Neighborhood Hits	371	Target Neighborhood Hits	243	Shared Neighborhood Hits	214
SwissProt Accessions	Q9DCN1, Q6PFA5	Gene names	Nudt12
Domain Architecture	No domain graphic available
Description	Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12).

PCDGI_HUMAN
θ value	3.0926 (rank : 329)	NC score	-0.002746 (rank : 471)
Query Neighborhood Hits	371	Target Neighborhood Hits	162	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y5F9, Q9Y5C5	Gene names	PCDHGB6
Domain Architecture
Description	Protocadherin gamma B6 precursor (PCDH-gamma-B6).

WAPL_MOUSE
θ value	3.0926 (rank : 330)	NC score	0.022427 (rank : 435)
Query Neighborhood Hits	371	Target Neighborhood Hits	158	Shared Neighborhood Hits	7
SwissProt Accessions	Q65Z40, Q6ZQE9	Gene names	Wapal, Kiaa0261, Wapl
Domain Architecture	No domain graphic available
Description	Wings apart-like protein homolog (Dioxin-inducible factor 2) (DIF-2).

AMPH_HUMAN
θ value	4.03905 (rank : 331)	NC score	0.023828 (rank : 429)
Query Neighborhood Hits	371	Target Neighborhood Hits	455	Shared Neighborhood Hits	19
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

ANR38_MOUSE
θ value	4.03905 (rank : 332)	NC score	0.458398 (rank : 223)
Query Neighborhood Hits	371	Target Neighborhood Hits	512	Shared Neighborhood Hits	228
SwissProt Accessions	Q6P9J5, Q8BV03	Gene names	Ankrd38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

CSPG3_MOUSE
θ value	4.03905 (rank : 333)	NC score	0.033211 (rank : 420)
Query Neighborhood Hits	371	Target Neighborhood Hits	657	Shared Neighborhood Hits	14
SwissProt Accessions	P55066, Q6P1E3, Q8C4F8	Gene names	Cspg3, Ncan
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

CT012_HUMAN
θ value	4.03905 (rank : 334)	NC score	0.290888 (rank : 296)
Query Neighborhood Hits	371	Target Neighborhood Hits	205	Shared Neighborhood Hits	166
SwissProt Accessions	Q9NVP4, Q4F7X1, Q5QPD9, Q5QPE0, Q68DN8, Q6ZMX9, Q96NF0, Q9H1E0, Q9H442	Gene names	C20orf12
Domain Architecture
Description	Protein C20orf12.

DRD4_MOUSE
θ value	4.03905 (rank : 335)	NC score	-0.009544 (rank : 476)
Query Neighborhood Hits	371	Target Neighborhood Hits	852	Shared Neighborhood Hits	2
SwissProt Accessions	P51436, O35838	Gene names	Drd4
Domain Architecture
Description	D(4) dopamine receptor (Dopamine D4 receptor) (D(2C) dopamine receptor).

EVI2A_MOUSE
θ value	4.03905 (rank : 336)	NC score	0.017824 (rank : 444)
Query Neighborhood Hits	371	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	P20934	Gene names	Evi2a, Evi-2, Evi-2a, Evi2
Domain Architecture
Description	EVI2A protein precursor (Ecotropic viral integration site 2A protein).

AN13B_HUMAN
θ value	5.27518 (rank : 337)	NC score	0.374070 (rank : 263)
Query Neighborhood Hits	371	Target Neighborhood Hits	265	Shared Neighborhood Hits	245
SwissProt Accessions	Q86YJ7, Q8N7S9	Gene names	ANKRD13B
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13B.

AN13B_MOUSE
θ value	5.27518 (rank : 338)	NC score	0.374907 (rank : 262)
Query Neighborhood Hits	371	Target Neighborhood Hits	276	Shared Neighborhood Hits	245
SwissProt Accessions	Q5F259, Q6IR40	Gene names	Ankrd13b
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13B.

AN13C_HUMAN
θ value	5.27518 (rank : 339)	NC score	0.351372 (rank : 271)
Query Neighborhood Hits	371	Target Neighborhood Hits	241	Shared Neighborhood Hits	230
SwissProt Accessions	Q8N6S4, Q5VYH4, Q5VYH5, Q6PJE4, Q9H0N9	Gene names	ANKRD13C
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13C.

AN13C_MOUSE
θ value	5.27518 (rank : 340)	NC score	0.343835 (rank : 272)
Query Neighborhood Hits	371	Target Neighborhood Hits	242	Shared Neighborhood Hits	226
SwissProt Accessions	Q3UX43, Q6P1G4	Gene names	Ankrd13c
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13C.

CETN2_HUMAN
θ value	5.27518 (rank : 341)	NC score	0.000443 (rank : 468)
Query Neighborhood Hits	371	Target Neighborhood Hits	213	Shared Neighborhood Hits	3
SwissProt Accessions	P41208, Q53XW1	Gene names	CETN2, CALT, CEN2
Domain Architecture
Description	Centrin-2 (Caltractin isoform 1).

CETN2_MOUSE
θ value	5.27518 (rank : 342)	NC score	0.000333 (rank : 469)
Query Neighborhood Hits	371	Target Neighborhood Hits	211	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R1K9, Q3UBB4, Q9CWM0	Gene names	Cetn2, Calt
Domain Architecture
Description	Centrin-2 (Caltractin isoform 1).

FURIN_HUMAN
θ value	5.27518 (rank : 343)	NC score	0.005449 (rank : 461)
Query Neighborhood Hits	371	Target Neighborhood Hits	52	Shared Neighborhood Hits	3
SwissProt Accessions	P09958, Q14336, Q6LBS3	Gene names	FURIN, FUR, PACE
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme).

FURIN_MOUSE
θ value	5.27518 (rank : 344)	NC score	0.005469 (rank : 460)
Query Neighborhood Hits	371	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	P23188	Gene names	Furin, Fur, Pcsk3
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme) (Prohormone convertase 3).

SUHW4_HUMAN
θ value	5.27518 (rank : 345)	NC score	-0.005667 (rank : 474)
Query Neighborhood Hits	371	Target Neighborhood Hits	860	Shared Neighborhood Hits	12
SwissProt Accessions	Q6N043, Q6MZM6, Q6N085, Q9H0U5, Q9HCI8, Q9NXS0	Gene names	SUHW4, KIAA1584
Domain Architecture	No domain graphic available
Description	Suppressor of hairy wing homolog 4.

TRPV1_MOUSE
θ value	5.27518 (rank : 346)	NC score	0.147428 (rank : 327)
Query Neighborhood Hits	371	Target Neighborhood Hits	189	Shared Neighborhood Hits	145
SwissProt Accessions	Q704Y3, Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0	Gene names	Trpv1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).

ASB5_HUMAN
θ value	6.88961 (rank : 347)	NC score	0.554483 (rank : 162)
Query Neighborhood Hits	371	Target Neighborhood Hits	283	Shared Neighborhood Hits	256
SwissProt Accessions	Q8WWX0	Gene names	ASB5
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 5 (ASB-5).

C2TA_MOUSE
θ value	6.88961 (rank : 348)	NC score	0.004603 (rank : 462)
Query Neighborhood Hits	371	Target Neighborhood Hits	131	Shared Neighborhood Hits	5
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

EP400_MOUSE
θ value	6.88961 (rank : 349)	NC score	0.005825 (rank : 459)
Query Neighborhood Hits	371	Target Neighborhood Hits	592	Shared Neighborhood Hits	17
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

FBX24_MOUSE
θ value	6.88961 (rank : 350)	NC score	0.026731 (rank : 425)
Query Neighborhood Hits	371	Target Neighborhood Hits	59	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D417	Gene names	Fbxo24, Fbx24
Domain Architecture	No domain graphic available
Description	F-box only protein 24.

GLI1_MOUSE
θ value	6.88961 (rank : 351)	NC score	-0.011627 (rank : 477)
Query Neighborhood Hits	371	Target Neighborhood Hits	785	Shared Neighborhood Hits	7
SwissProt Accessions	P47806, Q9QYK1	Gene names	Gli1, Gli
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI1 (Glioma-associated oncogene homolog).

LRP6_HUMAN
θ value	6.88961 (rank : 352)	NC score	0.006339 (rank : 455)
Query Neighborhood Hits	371	Target Neighborhood Hits	235	Shared Neighborhood Hits	12
SwissProt Accessions	O75581	Gene names	LRP6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

LRP6_MOUSE
θ value	6.88961 (rank : 353)	NC score	0.005844 (rank : 458)
Query Neighborhood Hits	371	Target Neighborhood Hits	232	Shared Neighborhood Hits	12
SwissProt Accessions	O88572	Gene names	Lrp6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

NEDD1_MOUSE
θ value	6.88961 (rank : 354)	NC score	0.001054 (rank : 467)
Query Neighborhood Hits	371	Target Neighborhood Hits	281	Shared Neighborhood Hits	4
SwissProt Accessions	P33215, Q6NXV3, Q8BN12, Q8BN86, Q8BQL9, Q9CWK2	Gene names	Nedd1, Nedd-1
Domain Architecture	No domain graphic available
Description	Protein NEDD1 (Neural precursor cell expressed developmentally down- regulated protein 1).

PCNT_MOUSE
θ value	6.88961 (rank : 355)	NC score	0.013328 (rank : 448)
Query Neighborhood Hits	371	Target Neighborhood Hits	1207	Shared Neighborhood Hits	36
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

PKP1_MOUSE
θ value	6.88961 (rank : 356)	NC score	0.003488 (rank : 464)
Query Neighborhood Hits	371	Target Neighborhood Hits	37	Shared Neighborhood Hits	2
SwissProt Accessions	P97350	Gene names	Pkp1
Domain Architecture
Description	Plakophilin-1.

ST14_HUMAN
θ value	6.88961 (rank : 357)	NC score	0.001125 (rank : 466)
Query Neighborhood Hits	371	Target Neighborhood Hits	409	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y5Y6, Q9BS01, Q9H3S0, Q9HB36, Q9HCA3	Gene names	ST14, PRSS14, SNC19, TADG15
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein).

TRPC6_HUMAN
θ value	6.88961 (rank : 358)	NC score	0.070470 (rank : 360)
Query Neighborhood Hits	371	Target Neighborhood Hits	171	Shared Neighborhood Hits	94
SwissProt Accessions	Q9Y210, Q9HCW3, Q9NQA8, Q9NQA9	Gene names	TRPC6, TRP6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6).

TYDP1_MOUSE
θ value	6.88961 (rank : 359)	NC score	0.009377 (rank : 452)
Query Neighborhood Hits	371	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BJ37, Q8VE39	Gene names	Tdp1
Domain Architecture
Description	Tyrosyl-DNA phosphodiesterase 1 (EC 3.1.4.-) (Tyr-DNA phosphodiesterase 1).

ZN533_HUMAN
θ value	6.88961 (rank : 360)	NC score	0.007269 (rank : 454)
Query Neighborhood Hits	371	Target Neighborhood Hits	85	Shared Neighborhood Hits	5
SwissProt Accessions	Q569K4, Q49A04, Q6ZMZ7, Q8IY01, Q8N8H2, Q96DK4	Gene names	ZNF533
Domain Architecture	No domain graphic available
Description	Zinc finger protein 533.

B2L12_HUMAN
θ value	8.99809 (rank : 361)	NC score	0.011779 (rank : 451)
Query Neighborhood Hits	371	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HB09, Q3SY11, Q96I96, Q9HB08	Gene names	BCL2L12, BPR
Domain Architecture	No domain graphic available
Description	Bcl-2-related proline-rich protein (Bcl-2-like 12 protein).

IASPP_HUMAN
θ value	8.99809 (rank : 362)	NC score	0.394741 (rank : 249)
Query Neighborhood Hits	371	Target Neighborhood Hits	688	Shared Neighborhood Hits	248
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

K0195_MOUSE
θ value	8.99809 (rank : 363)	NC score	0.006158 (rank : 456)
Query Neighborhood Hits	371	Target Neighborhood Hits	45	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TSH8, Q80U66, Q8BL05, Q8K0Q0, Q91VY1	Gene names	Kiaa0195
Domain Architecture	No domain graphic available
Description	Protein KIAA0195.

KIRR3_MOUSE
θ value	8.99809 (rank : 364)	NC score	-0.003392 (rank : 472)
Query Neighborhood Hits	371	Target Neighborhood Hits	292	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BR86, Q6P555, Q810H3, Q8BGQ5, Q8BRS8	Gene names	Kirrel3, Kiaa1867
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3).

MCRS1_HUMAN
θ value	8.99809 (rank : 365)	NC score	0.007383 (rank : 453)
Query Neighborhood Hits	371	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	Q96EZ8, O14742, O75497, Q6VN53	Gene names	MCRS1, MSP58
Domain Architecture
Description	Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle- regulated factor p78) (MCRS2).

MYCPP_HUMAN
θ value	8.99809 (rank : 366)	NC score	0.004151 (rank : 463)
Query Neighborhood Hits	371	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	Q7Z401, Q14655, Q86T77, Q8IVX2, Q8NB93	Gene names	MYCPBP, IRLB
Domain Architecture	No domain graphic available
Description	C-myc promoter-binding protein.

PCDGH_HUMAN
θ value	8.99809 (rank : 367)	NC score	-0.003642 (rank : 473)
Query Neighborhood Hits	371	Target Neighborhood Hits	164	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y5G0, Q9Y5C6	Gene names	PCDHGB5
Domain Architecture
Description	Protocadherin gamma B5 precursor (PCDH-gamma-B5).

REL_HUMAN
θ value	8.99809 (rank : 368)	NC score	0.021639 (rank : 436)
Query Neighborhood Hits	371	Target Neighborhood Hits	31	Shared Neighborhood Hits	6
SwissProt Accessions	Q04864, Q2PNZ7, Q6LDY0	Gene names	REL
Domain Architecture
Description	C-Rel proto-oncogene protein (C-Rel protein).

RHBT1_HUMAN
θ value	8.99809 (rank : 369)	NC score	0.002194 (rank : 465)
Query Neighborhood Hits	371	Target Neighborhood Hits	262	Shared Neighborhood Hits	6
SwissProt Accessions	O94844	Gene names	RHOBTB1, KIAA0740
Domain Architecture
Description	Rho-related BTB domain-containing protein 1.

SPB5_HUMAN
θ value	8.99809 (rank : 370)	NC score	-0.002122 (rank : 470)
Query Neighborhood Hits	371	Target Neighborhood Hits	91	Shared Neighborhood Hits	3
SwissProt Accessions	P36952	Gene names	SERPINB5, PI5
Domain Architecture
Description	Serpin B5 precursor (Maspin) (Protease inhibitor 5).

TRPC7_HUMAN
θ value	8.99809 (rank : 371)	NC score	0.042708 (rank : 417)
Query Neighborhood Hits	371	Target Neighborhood Hits	123	Shared Neighborhood Hits	63
SwissProt Accessions	Q9HCX4	Gene names	TRPC7, TRP7
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (TRP7 protein).

ABTB1_HUMAN
θ value	θ > 10 (rank : 372)	NC score	0.183365 (rank : 318)
Query Neighborhood Hits	371	Target Neighborhood Hits	325	Shared Neighborhood Hits	158
SwissProt Accessions	Q969K4, Q6ZNU9, Q71MF1, Q96S62, Q96S63	Gene names	ABTB1, BPOZ
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 1 (Elongation factor 1A-binding protein).

ABTB1_MOUSE
θ value	θ > 10 (rank : 373)	NC score	0.212002 (rank : 314)
Query Neighborhood Hits	371	Target Neighborhood Hits	349	Shared Neighborhood Hits	174
SwissProt Accessions	Q99LJ2, Q8C2K7, Q91XU4	Gene names	Abtb1, Bpoz
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 1.

ANKF1_HUMAN
θ value	θ > 10 (rank : 374)	NC score	0.085639 (rank : 353)
Query Neighborhood Hits	371	Target Neighborhood Hits	126	Shared Neighborhood Hits	67
SwissProt Accessions	Q8N957	Gene names	ANKFN1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and fibronectin type-III domain-containing protein 1.

ANKY1_HUMAN
θ value	θ > 10 (rank : 375)	NC score	0.373078 (rank : 264)
Query Neighborhood Hits	371	Target Neighborhood Hits	248	Shared Neighborhood Hits	198
SwissProt Accessions	Q9P2S6, Q8IYX5, Q8NDK5, Q9NX10	Gene names	ANKMY1, TSAL1, ZMYND13
Domain Architecture
Description	Ankyrin repeat and MYND domain-containing protein 1 (Testis-specific ankyrin-like protein 1) (Zinc-finger MYND domain-containing protein 13).

ANKZ1_HUMAN
θ value	θ > 10 (rank : 376)	NC score	0.223680 (rank : 312)
Query Neighborhood Hits	371	Target Neighborhood Hits	236	Shared Neighborhood Hits	152
SwissProt Accessions	Q9H8Y5, Q9NVZ4	Gene names	ANKZF1, ZNF744
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1 (Zinc finger protein 744).

ANKZ1_MOUSE
θ value	θ > 10 (rank : 377)	NC score	0.236514 (rank : 311)
Query Neighborhood Hits	371	Target Neighborhood Hits	208	Shared Neighborhood Hits	147
SwissProt Accessions	Q80UU1, Q9CZF5	Gene names	Ankzf1, D1Ertd161e
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1.

ANR33_HUMAN
θ value	θ > 10 (rank : 378)	NC score	0.480667 (rank : 210)
Query Neighborhood Hits	371	Target Neighborhood Hits	215	Shared Neighborhood Hits	209
SwissProt Accessions	Q7Z3H0, Q5K619, Q5K621, Q5K622, Q5K623, Q5K624, Q6ZUN0	Gene names	ANKRD33, C12orf7
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

ANR33_MOUSE
θ value	θ > 10 (rank : 379)	NC score	0.483108 (rank : 209)
Query Neighborhood Hits	371	Target Neighborhood Hits	225	Shared Neighborhood Hits	219
SwissProt Accessions	Q8BXP5, Q8BXP4, Q8R1Z1	Gene names	Ankrd33
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

ANR45_HUMAN
θ value	θ > 10 (rank : 380)	NC score	0.385151 (rank : 257)
Query Neighborhood Hits	371	Target Neighborhood Hits	201	Shared Neighborhood Hits	180
SwissProt Accessions	Q5TZF3, Q6ZST1	Gene names	ANKRD45
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 45.

ANR45_MOUSE
θ value	θ > 10 (rank : 381)	NC score	0.407258 (rank : 244)
Query Neighborhood Hits	371	Target Neighborhood Hits	204	Shared Neighborhood Hits	185
SwissProt Accessions	Q810N6	Gene names	Ankrd45
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 45.

APBB2_HUMAN
θ value	θ > 10 (rank : 382)	NC score	0.056668 (rank : 394)
Query Neighborhood Hits	371	Target Neighborhood Hits	96	Shared Neighborhood Hits	13
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

APBB2_MOUSE
θ value	θ > 10 (rank : 383)	NC score	0.055357 (rank : 401)
Query Neighborhood Hits	371	Target Neighborhood Hits	88	Shared Neighborhood Hits	14
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

ARFG1_HUMAN
θ value	θ > 10 (rank : 384)	NC score	0.064975 (rank : 378)
Query Neighborhood Hits	371	Target Neighborhood Hits	60	Shared Neighborhood Hits	18
SwissProt Accessions	Q8N6T3, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0	Gene names	ARFGAP1, ARF1GAP
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

ARFG1_MOUSE
θ value	θ > 10 (rank : 385)	NC score	0.067010 (rank : 373)
Query Neighborhood Hits	371	Target Neighborhood Hits	51	Shared Neighborhood Hits	19
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

ARFG3_HUMAN
θ value	θ > 10 (rank : 386)	NC score	0.065640 (rank : 377)
Query Neighborhood Hits	371	Target Neighborhood Hits	56	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ARFG3_MOUSE
θ value	θ > 10 (rank : 387)	NC score	0.066227 (rank : 374)
Query Neighborhood Hits	371	Target Neighborhood Hits	80	Shared Neighborhood Hits	19
SwissProt Accessions	Q9D8S3, Q99KN8	Gene names	Arfgap3
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ASB14_HUMAN
θ value	θ > 10 (rank : 388)	NC score	0.372949 (rank : 265)
Query Neighborhood Hits	371	Target Neighborhood Hits	187	Shared Neighborhood Hits	170
SwissProt Accessions	Q8WXK2	Gene names	ASB14
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 14 (ASB-14).

BAG3_HUMAN
θ value	θ > 10 (rank : 389)	NC score	0.129178 (rank : 335)
Query Neighborhood Hits	371	Target Neighborhood Hits	314	Shared Neighborhood Hits	23
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

BAG3_MOUSE
θ value	θ > 10 (rank : 390)	NC score	0.111414 (rank : 341)
Query Neighborhood Hits	371	Target Neighborhood Hits	513	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

BAT4_HUMAN
θ value	θ > 10 (rank : 391)	NC score	0.170082 (rank : 322)
Query Neighborhood Hits	371	Target Neighborhood Hits	157	Shared Neighborhood Hits	105
SwissProt Accessions	O95872	Gene names	BAT4, G5
Domain Architecture
Description	Protein BAT4 (HLA-B-associated transcript 4) (G5 protein).

BAT4_MOUSE
θ value	θ > 10 (rank : 392)	NC score	0.189858 (rank : 317)
Query Neighborhood Hits	371	Target Neighborhood Hits	171	Shared Neighborhood Hits	115
SwissProt Accessions	Q61858, Q9R065	Gene names	Bat4, Bat-4, G5
Domain Architecture
Description	Protein BAT4 (HLA-B-associated transcript 4) (G5 protein).

CENA1_HUMAN
θ value	θ > 10 (rank : 393)	NC score	0.069366 (rank : 363)
Query Neighborhood Hits	371	Target Neighborhood Hits	87	Shared Neighborhood Hits	19
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

CENA2_HUMAN
θ value	θ > 10 (rank : 394)	NC score	0.062797 (rank : 385)
Query Neighborhood Hits	371	Target Neighborhood Hits	83	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

CENA2_MOUSE
θ value	θ > 10 (rank : 395)	NC score	0.063478 (rank : 384)
Query Neighborhood Hits	371	Target Neighborhood Hits	68	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

CEND1_HUMAN
θ value	θ > 10 (rank : 396)	NC score	0.057309 (rank : 391)
Query Neighborhood Hits	371	Target Neighborhood Hits	284	Shared Neighborhood Hits	30
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CEND1_MOUSE
θ value	θ > 10 (rank : 397)	NC score	0.053688 (rank : 404)
Query Neighborhood Hits	371	Target Neighborhood Hits	260	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CEND2_HUMAN
θ value	θ > 10 (rank : 398)	NC score	0.050004 (rank : 415)
Query Neighborhood Hits	371	Target Neighborhood Hits	166	Shared Neighborhood Hits	22
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

CEND3_HUMAN
θ value	θ > 10 (rank : 399)	NC score	0.051834 (rank : 411)
Query Neighborhood Hits	371	Target Neighborhood Hits	275	Shared Neighborhood Hits	24
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CEND3_MOUSE
θ value	θ > 10 (rank : 400)	NC score	0.051020 (rank : 413)
Query Neighborhood Hits	371	Target Neighborhood Hits	228	Shared Neighborhood Hits	27
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CMTA1_HUMAN
θ value	θ > 10 (rank : 401)	NC score	0.127804 (rank : 336)
Query Neighborhood Hits	371	Target Neighborhood Hits	217	Shared Neighborhood Hits	99
SwissProt Accessions	Q9Y6Y1, Q5VUE1	Gene names	CAMTA1, KIAA0833
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 1.

CMTA2_HUMAN
θ value	θ > 10 (rank : 402)	NC score	0.102675 (rank : 343)
Query Neighborhood Hits	371	Target Neighborhood Hits	199	Shared Neighborhood Hits	86
SwissProt Accessions	O94983, Q7Z6M8, Q8N3V0, Q8NDG4, Q96G17	Gene names	CAMTA2, KIAA0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

CMTA2_MOUSE
θ value	θ > 10 (rank : 403)	NC score	0.092950 (rank : 344)
Query Neighborhood Hits	371	Target Neighborhood Hits	216	Shared Neighborhood Hits	75
SwissProt Accessions	Q80Y50, Q3TFK0, Q5SX68, Q80TP1, Q8R0D9, Q8R2N5	Gene names	Camta2, Kiaa0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

CRUM1_HUMAN
θ value	θ > 10 (rank : 404)	NC score	0.053366 (rank : 405)
Query Neighborhood Hits	371	Target Neighborhood Hits	457	Shared Neighborhood Hits	11
SwissProt Accessions	P82279, Q5K3A6, Q5TC28, Q5VUT1, Q6N027, Q8WWY0	Gene names	CRB1
Domain Architecture
Description	Crumbs homolog 1 precursor.

CRUM1_MOUSE
θ value	θ > 10 (rank : 405)	NC score	0.053145 (rank : 407)
Query Neighborhood Hits	371	Target Neighborhood Hits	444	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VHS2, Q6ST50, Q71JF2, Q8BGR4	Gene names	Crb1
Domain Architecture	No domain graphic available
Description	Crumbs homolog 1 precursor.

CRUM2_HUMAN
θ value	θ > 10 (rank : 406)	NC score	0.054121 (rank : 403)
Query Neighborhood Hits	371	Target Neighborhood Hits	453	Shared Neighborhood Hits	9
SwissProt Accessions	Q5IJ48, Q5JS41, Q5JS43, Q6ZTA9, Q6ZWI6	Gene names	CRB2
Domain Architecture	No domain graphic available
Description	Crumbs homolog 2 precursor (Crumbs-like protein 2).

CT012_MOUSE
θ value	θ > 10 (rank : 407)	NC score	0.320157 (rank : 285)
Query Neighborhood Hits	371	Target Neighborhood Hits	229	Shared Neighborhood Hits	172
SwissProt Accessions	Q8C008, Q8C060	Gene names
Domain Architecture	No domain graphic available
Description	Protein C20orf12 homolog.

DLL3_MOUSE
θ value	θ > 10 (rank : 408)	NC score	0.050251 (rank : 414)
Query Neighborhood Hits	371	Target Neighborhood Hits	399	Shared Neighborhood Hits	9
SwissProt Accessions	O88516, O35675, Q80W06, Q9QWL9, Q9QWZ7	Gene names	Dll3
Domain Architecture	No domain graphic available
Description	Delta-like protein 3 precursor (Drosophila Delta homolog 3) (M-Delta- 3).

DNER_HUMAN
θ value	θ > 10 (rank : 409)	NC score	0.054645 (rank : 402)
Query Neighborhood Hits	371	Target Neighborhood Hits	460	Shared Neighborhood Hits	10
SwissProt Accessions	Q8NFT8, Q53R88, Q53TP7, Q53TQ5, Q8IYT0, Q8TB42, Q9NTF1, Q9UDM2	Gene names	DNER, BET
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor.

DNER_MOUSE
θ value	θ > 10 (rank : 410)	NC score	0.055445 (rank : 399)
Query Neighborhood Hits	371	Target Neighborhood Hits	413	Shared Neighborhood Hits	9
SwissProt Accessions	Q8JZM4, Q3U697, Q8R226, Q8R4T6, Q8VD97	Gene names	Dner, Bet, Bret
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor (Brain EGF repeat-containing transmembrane protein).

EGFL9_HUMAN
θ value	θ > 10 (rank : 411)	NC score	0.052145 (rank : 409)
Query Neighborhood Hits	371	Target Neighborhood Hits	365	Shared Neighborhood Hits	9
SwissProt Accessions	Q6UY11, Q9BQ54	Gene names	EGFL9
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 9 precursor (Multiple EGF-like domain protein 9).

EGFL9_MOUSE
θ value	θ > 10 (rank : 412)	NC score	0.051920 (rank : 410)
Query Neighborhood Hits	371	Target Neighborhood Hits	379	Shared Neighborhood Hits	9
SwissProt Accessions	Q8K1E3, Q9QYP3	Gene names	Egfl9
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 9 precursor (Multiple EGF-like domain protein 9) (Endothelial cell-specific protein S-1).

GAS7_HUMAN
θ value	θ > 10 (rank : 413)	NC score	0.085754 (rank : 352)
Query Neighborhood Hits	371	Target Neighborhood Hits	258	Shared Neighborhood Hits	18
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

GAS7_MOUSE
θ value	θ > 10 (rank : 414)	NC score	0.086248 (rank : 350)
Query Neighborhood Hits	371	Target Neighborhood Hits	259	Shared Neighborhood Hits	20
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

GNPTA_MOUSE
θ value	θ > 10 (rank : 415)	NC score	0.058561 (rank : 388)
Query Neighborhood Hits	371	Target Neighborhood Hits	47	Shared Neighborhood Hits	9
SwissProt Accessions	Q69ZN6, Q3U3K6, Q3US34	Gene names	Gnptab, Gnpta, Kiaa1208
Domain Architecture	No domain graphic available
Description	N-acetylglucosamine-1-phosphotransferase subunits alpha/beta precursor (EC 2.7.8.17) (GlcNAc-1-phosphotransferase alpha/beta subunits) (UDP- N-acetylglucosamine-1-phosphotransferase alpha/beta subunits) (Stealth protein GNPTAB) [Contains: N-acetylglucosamine-1-phosphotransferase subunit alpha; N-acetylglucosamine-1-phosphotransferase subunit beta].

IASPP_MOUSE
θ value	θ > 10 (rank : 416)	NC score	0.352336 (rank : 270)
Query Neighborhood Hits	371	Target Neighborhood Hits	1024	Shared Neighborhood Hits	249
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IKBL_HUMAN
θ value	θ > 10 (rank : 417)	NC score	0.216790 (rank : 313)
Query Neighborhood Hits	371	Target Neighborhood Hits	168	Shared Neighborhood Hits	137
SwissProt Accessions	Q9UBC1, Q14625, Q9UBX4	Gene names	NFKBIL1, IKBL
Domain Architecture
Description	NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like) (I- kappa-B-like) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1).

IKBL_MOUSE
θ value	θ > 10 (rank : 418)	NC score	0.211679 (rank : 315)
Query Neighborhood Hits	371	Target Neighborhood Hits	196	Shared Neighborhood Hits	138
SwissProt Accessions	O88995, Q91X16, Q9R1Y3	Gene names	Nfkbil1, Ikbl
Domain Architecture
Description	NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like) (I- kappa-B-like) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1).

JAG1_HUMAN
θ value	θ > 10 (rank : 419)	NC score	0.055766 (rank : 398)
Query Neighborhood Hits	371	Target Neighborhood Hits	514	Shared Neighborhood Hits	11
SwissProt Accessions	P78504, O14902, O15122, Q15816	Gene names	JAG1, JAGL1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (hJ1) (CD339 antigen).

JAG1_MOUSE
θ value	θ > 10 (rank : 420)	NC score	0.055386 (rank : 400)
Query Neighborhood Hits	371	Target Neighborhood Hits	518	Shared Neighborhood Hits	10
SwissProt Accessions	Q9QXX0	Gene names	Jag1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (CD339 antigen).

JAG2_HUMAN
θ value	θ > 10 (rank : 421)	NC score	0.055779 (rank : 397)
Query Neighborhood Hits	371	Target Neighborhood Hits	491	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y219, Q9UE17, Q9UE99, Q9UNK8, Q9Y6P9, Q9Y6Q0	Gene names	JAG2
Domain Architecture
Description	Jagged-2 precursor (Jagged2) (HJ2).

JAG2_MOUSE
θ value	θ > 10 (rank : 422)	NC score	0.056955 (rank : 393)
Query Neighborhood Hits	371	Target Neighborhood Hits	504	Shared Neighborhood Hits	13
SwissProt Accessions	Q9QYE5, O55139, O70219	Gene names	Jag2
Domain Architecture
Description	Jagged-2 precursor (Jagged2).

LCE1B_HUMAN
θ value	θ > 10 (rank : 423)	NC score	0.056490 (rank : 395)
Query Neighborhood Hits	371	Target Neighborhood Hits	58	Shared Neighborhood Hits	7
SwissProt Accessions	Q5T7P3	Gene names	LCE1B, LEP2, SPRL2A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1B (Late envelope protein 2) (Small proline-rich-like epidermal differentiation complex protein 2A).

LCE1C_HUMAN
θ value	θ > 10 (rank : 424)	NC score	0.053224 (rank : 406)
Query Neighborhood Hits	371	Target Neighborhood Hits	65	Shared Neighborhood Hits	7
SwissProt Accessions	Q5T751	Gene names	LCE1C, LEP3
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1C (Late envelope protein 3).

LCE1D_HUMAN
θ value	θ > 10 (rank : 425)	NC score	0.052859 (rank : 408)
Query Neighborhood Hits	371	Target Neighborhood Hits	44	Shared Neighborhood Hits	6
SwissProt Accessions	Q5T752	Gene names	LCE1D, LEP4
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1D (Late envelope protein 4).

LRRK1_MOUSE
θ value	θ > 10 (rank : 426)	NC score	0.056163 (rank : 396)
Query Neighborhood Hits	371	Target Neighborhood Hits	1267	Shared Neighborhood Hits	120
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

MAGI1_HUMAN
θ value	θ > 10 (rank : 427)	NC score	0.086796 (rank : 349)
Query Neighborhood Hits	371	Target Neighborhood Hits	388	Shared Neighborhood Hits	17
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI1_MOUSE
θ value	θ > 10 (rank : 428)	NC score	0.089128 (rank : 347)
Query Neighborhood Hits	371	Target Neighborhood Hits	403	Shared Neighborhood Hits	19
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MAGI2_HUMAN
θ value	θ > 10 (rank : 429)	NC score	0.086013 (rank : 351)
Query Neighborhood Hits	371	Target Neighborhood Hits	373	Shared Neighborhood Hits	17
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MAGI2_MOUSE
θ value	θ > 10 (rank : 430)	NC score	0.092629 (rank : 345)
Query Neighborhood Hits	371	Target Neighborhood Hits	370	Shared Neighborhood Hits	15
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

PIN1_HUMAN
θ value	θ > 10 (rank : 431)	NC score	0.136388 (rank : 331)
Query Neighborhood Hits	371	Target Neighborhood Hits	59	Shared Neighborhood Hits	13
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PIN1_MOUSE
θ value	θ > 10 (rank : 432)	NC score	0.135312 (rank : 332)
Query Neighborhood Hits	371	Target Neighborhood Hits	60	Shared Neighborhood Hits	13
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PINL_HUMAN
θ value	θ > 10 (rank : 433)	NC score	0.164149 (rank : 323)
Query Neighborhood Hits	371	Target Neighborhood Hits	47	Shared Neighborhood Hits	13
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

PKHA5_HUMAN
θ value	θ > 10 (rank : 434)	NC score	0.109767 (rank : 342)
Query Neighborhood Hits	371	Target Neighborhood Hits	455	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PRP40_HUMAN
θ value	θ > 10 (rank : 435)	NC score	0.084877 (rank : 354)
Query Neighborhood Hits	371	Target Neighborhood Hits	442	Shared Neighborhood Hits	27
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

PRP40_MOUSE
θ value	θ > 10 (rank : 436)	NC score	0.087254 (rank : 348)
Query Neighborhood Hits	371	Target Neighborhood Hits	447	Shared Neighborhood Hits	31
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

RCBT1_HUMAN
θ value	θ > 10 (rank : 437)	NC score	0.062443 (rank : 386)
Query Neighborhood Hits	371	Target Neighborhood Hits	158	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NDN9, Q969U9	Gene names	RCBTB1, CLLD7, E4.5
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1) (Chronic lymphocytic leukemia deletion region gene 7 protein) (CLL deletion region gene 7 protein).

RCBT1_MOUSE
θ value	θ > 10 (rank : 438)	NC score	0.063938 (rank : 381)
Query Neighborhood Hits	371	Target Neighborhood Hits	157	Shared Neighborhood Hits	11
SwissProt Accessions	Q6NXM2, Q8BTZ6, Q8BZV0	Gene names	Rcbtb1
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1).

RCBT2_HUMAN
θ value	θ > 10 (rank : 439)	NC score	0.067970 (rank : 369)
Query Neighborhood Hits	371	Target Neighborhood Hits	158	Shared Neighborhood Hits	13
SwissProt Accessions	O95199	Gene names	RCBTB2, CHC1L, RLG
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like) (CHC1-L) (RCC1-like G exchanging factor).

RCBT2_MOUSE
θ value	θ > 10 (rank : 440)	NC score	0.068598 (rank : 367)
Query Neighborhood Hits	371	Target Neighborhood Hits	156	Shared Neighborhood Hits	13
SwissProt Accessions	Q99LJ7, Q3TUA3, Q8BMG2	Gene names	Rcbtb2, Chc1l
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like).

RCC1_HUMAN
θ value	θ > 10 (rank : 441)	NC score	0.068098 (rank : 368)
Query Neighborhood Hits	371	Target Neighborhood Hits	47	Shared Neighborhood Hits	6
SwissProt Accessions	P18754	Gene names	RCC1, CHC1
Domain Architecture
Description	Regulator of chromosome condensation (Chromosome condensation protein 1) (Cell cycle regulatory protein).

RCC1_MOUSE
θ value	θ > 10 (rank : 442)	NC score	0.066081 (rank : 375)
Query Neighborhood Hits	371	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VE37, Q3UDB6	Gene names	Rcc1, Chc1
Domain Architecture	No domain graphic available
Description	Regulator of chromosome condensation (Chromosome condensation protein 1).

RCC2_HUMAN
θ value	θ > 10 (rank : 443)	NC score	0.071104 (rank : 359)
Query Neighborhood Hits	371	Target Neighborhood Hits	36	Shared Neighborhood Hits	8
SwissProt Accessions	Q9P258, Q8IVL9, Q9BSN6, Q9NPV8	Gene names	RCC2, KIAA1470, TD60
Domain Architecture	No domain graphic available
Description	Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like protein TD- 60).

RCC2_MOUSE
θ value	θ > 10 (rank : 444)	NC score	0.070413 (rank : 361)
Query Neighborhood Hits	371	Target Neighborhood Hits	37	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BK67, Q6ZPQ0	Gene names	Rcc2, Kiaa1470
Domain Architecture	No domain graphic available
Description	Protein RCC2.

RPGR_HUMAN
θ value	θ > 10 (rank : 445)	NC score	0.072009 (rank : 357)
Query Neighborhood Hits	371	Target Neighborhood Hits	279	Shared Neighborhood Hits	15
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

RPGR_MOUSE
θ value	θ > 10 (rank : 446)	NC score	0.067527 (rank : 372)
Query Neighborhood Hits	371	Target Neighborhood Hits	281	Shared Neighborhood Hits	17
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

SAV1_HUMAN
θ value	θ > 10 (rank : 447)	NC score	0.173550 (rank : 321)
Query Neighborhood Hits	371	Target Neighborhood Hits	51	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
θ value	θ > 10 (rank : 448)	NC score	0.173769 (rank : 320)
Query Neighborhood Hits	371	Target Neighborhood Hits	48	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

SETD2_HUMAN
θ value	θ > 10 (rank : 449)	NC score	0.063581 (rank : 383)
Query Neighborhood Hits	371	Target Neighborhood Hits	412	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

SMAP1_HUMAN
θ value	θ > 10 (rank : 450)	NC score	0.067863 (rank : 370)
Query Neighborhood Hits	371	Target Neighborhood Hits	98	Shared Neighborhood Hits	18
SwissProt Accessions	Q8IYB5, Q53H70, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4	Gene names	SMAP1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMAP1_MOUSE
θ value	θ > 10 (rank : 451)	NC score	0.070061 (rank : 362)
Query Neighborhood Hits	371	Target Neighborhood Hits	120	Shared Neighborhood Hits	20
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMP1L_HUMAN
θ value	θ > 10 (rank : 452)	NC score	0.069013 (rank : 364)
Query Neighborhood Hits	371	Target Neighborhood Hits	74	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

SMP1L_MOUSE
θ value	θ > 10 (rank : 453)	NC score	0.068884 (rank : 366)
Query Neighborhood Hits	371	Target Neighborhood Hits	70	Shared Neighborhood Hits	19
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

SRGEF_HUMAN
θ value	θ > 10 (rank : 454)	NC score	0.073536 (rank : 356)
Query Neighborhood Hits	371	Target Neighborhood Hits	33	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UGK8, Q9UGK9	Gene names	SERGEF, DELGEF, GNEFR
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

SRGEF_MOUSE
θ value	θ > 10 (rank : 455)	NC score	0.071440 (rank : 358)
Query Neighborhood Hits	371	Target Neighborhood Hits	37	Shared Neighborhood Hits	8
SwissProt Accessions	Q80YD6, Q9QXB7	Gene names	Sergef, Delgef, Gnefr
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

STXB4_HUMAN
θ value	θ > 10 (rank : 456)	NC score	0.058247 (rank : 389)
Query Neighborhood Hits	371	Target Neighborhood Hits	616	Shared Neighborhood Hits	31
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_MOUSE
θ value	θ > 10 (rank : 457)	NC score	0.057443 (rank : 390)
Query Neighborhood Hits	371	Target Neighborhood Hits	629	Shared Neighborhood Hits	34
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

TRPC3_HUMAN
θ value	θ > 10 (rank : 458)	NC score	0.051068 (rank : 412)
Query Neighborhood Hits	371	Target Neighborhood Hits	137	Shared Neighborhood Hits	72
SwissProt Accessions	Q13507, O00593, Q15660	Gene names	TRPC3, TRP3
Domain Architecture
Description	Short transient receptor potential channel 3 (TrpC3) (Htrp-3) (Htrp3).

TRPV1_HUMAN
θ value	θ > 10 (rank : 459)	NC score	0.136566 (rank : 330)
Query Neighborhood Hits	371	Target Neighborhood Hits	184	Shared Neighborhood Hits	137
SwissProt Accessions	Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22	Gene names	TRPV1, VR1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Capsaicin receptor).

TRPV2_HUMAN
θ value	θ > 10 (rank : 460)	NC score	0.122977 (rank : 337)
Query Neighborhood Hits	371	Target Neighborhood Hits	130	Shared Neighborhood Hits	103
SwissProt Accessions	Q9Y5S1, Q9Y670	Gene names	TRPV2, VRL
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1).

TRPV2_MOUSE
θ value	θ > 10 (rank : 461)	NC score	0.089189 (rank : 346)
Query Neighborhood Hits	371	Target Neighborhood Hits	111	Shared Neighborhood Hits	83
SwissProt Accessions	Q9WTR1, Q99K71	Gene names	Trpv2, Grc
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Growth factor-regulated calcium channel) (GRC).

TRPV3_HUMAN
θ value	θ > 10 (rank : 462)	NC score	0.145161 (rank : 329)
Query Neighborhood Hits	371	Target Neighborhood Hits	198	Shared Neighborhood Hits	131
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

TRPV3_MOUSE
θ value	θ > 10 (rank : 463)	NC score	0.147255 (rank : 328)
Query Neighborhood Hits	371	Target Neighborhood Hits	188	Shared Neighborhood Hits	121
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

TRPV4_HUMAN
θ value	θ > 10 (rank : 464)	NC score	0.069004 (rank : 365)
Query Neighborhood Hits	371	Target Neighborhood Hits	150	Shared Neighborhood Hits	71
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TRPV4_MOUSE
θ value	θ > 10 (rank : 465)	NC score	0.060936 (rank : 387)
Query Neighborhood Hits	371	Target Neighborhood Hits	117	Shared Neighborhood Hits	68
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TRPV5_HUMAN
θ value	θ > 10 (rank : 466)	NC score	0.308358 (rank : 290)
Query Neighborhood Hits	371	Target Neighborhood Hits	261	Shared Neighborhood Hits	214
SwissProt Accessions	Q9NQA5, Q8NDW5, Q8NDX7, Q8NDX8, Q96PM6	Gene names	TRPV5, ECAC1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Calcium transport protein 2) (CaT2).

TRPV6_HUMAN
θ value	θ > 10 (rank : 467)	NC score	0.302164 (rank : 292)
Query Neighborhood Hits	371	Target Neighborhood Hits	262	Shared Neighborhood Hits	214
SwissProt Accessions	Q9H1D0, Q8TDL3, Q8WXR8, Q96LC5, Q9H1D1, Q9H296	Gene names	TRPV6, ECAC2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1) (CaT-like) (CaT-L).

WBS16_HUMAN
θ value	θ > 10 (rank : 468)	NC score	0.063719 (rank : 382)
Query Neighborhood Hits	371	Target Neighborhood Hits	29	Shared Neighborhood Hits	6
SwissProt Accessions	Q96I51, Q548B1, Q9H0G7	Gene names	WBSCR16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein (RCC1-like G exchanging factor-like protein).

WBS16_MOUSE
θ value	θ > 10 (rank : 469)	NC score	0.064864 (rank : 379)
Query Neighborhood Hits	371	Target Neighborhood Hits	31	Shared Neighborhood Hits	6
SwissProt Accessions	Q9CYF5	Gene names	Wbscr16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein homolog.

WWC1_HUMAN
θ value	θ > 10 (rank : 470)	NC score	0.150983 (rank : 325)
Query Neighborhood Hits	371	Target Neighborhood Hits	290	Shared Neighborhood Hits	28
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
θ value	θ > 10 (rank : 471)	NC score	0.150082 (rank : 326)
Query Neighborhood Hits	371	Target Neighborhood Hits	290	Shared Neighborhood Hits	25
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

WWOX_HUMAN
θ value	θ > 10 (rank : 472)	NC score	0.132475 (rank : 333)
Query Neighborhood Hits	371	Target Neighborhood Hits	115	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

WWOX_MOUSE
θ value	θ > 10 (rank : 473)	NC score	0.131213 (rank : 334)
Query Neighborhood Hits	371	Target Neighborhood Hits	118	Shared Neighborhood Hits	13
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

WWTR1_HUMAN
θ value	θ > 10 (rank : 474)	NC score	0.114770 (rank : 339)
Query Neighborhood Hits	371	Target Neighborhood Hits	76	Shared Neighborhood Hits	14
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

WWTR1_MOUSE
θ value	θ > 10 (rank : 475)	NC score	0.115877 (rank : 338)
Query Neighborhood Hits	371	Target Neighborhood Hits	54	Shared Neighborhood Hits	13
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

YAP1_HUMAN
θ value	θ > 10 (rank : 476)	NC score	0.111461 (rank : 340)
Query Neighborhood Hits	371	Target Neighborhood Hits	173	Shared Neighborhood Hits	19
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

YAP1_MOUSE
θ value	θ > 10 (rank : 477)	NC score	0.191257 (rank : 316)
Query Neighborhood Hits	371	Target Neighborhood Hits	96	Shared Neighborhood Hits	16
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

Hits sorted by NC score

HECD1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	371	Target Neighborhood Hits	371	Shared Neighborhood Hits	371
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

ANR39_HUMAN
NC score	0.668495 (rank : 2)	θ value	1.02475e-11 (rank : 29)
Query Neighborhood Hits	371	Target Neighborhood Hits	285	Shared Neighborhood Hits	268
SwissProt Accessions	Q53RE8, Q59FU2, Q8N5X5, Q9P0S5	Gene names	ANKRD39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ANR39_MOUSE
NC score	0.666839 (rank : 3)	θ value	2.98157e-11 (rank : 30)
Query Neighborhood Hits	371	Target Neighborhood Hits	284	Shared Neighborhood Hits	266
SwissProt Accessions	Q9D2X0	Gene names	Ankrd39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

PSD10_HUMAN
NC score	0.659023 (rank : 4)	θ value	8.11959e-09 (rank : 44)
Query Neighborhood Hits	371	Target Neighborhood Hits	301	Shared Neighborhood Hits	270
SwissProt Accessions	O75832	Gene names	PSMD10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

PSD10_MOUSE
NC score	0.658925 (rank : 5)	θ value	6.21693e-09 (rank : 43)
Query Neighborhood Hits	371	Target Neighborhood Hits	293	Shared Neighborhood Hits	268
SwissProt Accessions	Q9Z2X2, Q9D7N8	Gene names	Psmd10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

ANR29_HUMAN
NC score	0.650661 (rank : 6)	θ value	1.29631e-06 (rank : 91)
Query Neighborhood Hits	371	Target Neighborhood Hits	294	Shared Neighborhood Hits	271
SwissProt Accessions	Q8N6D5, Q6ZWE8, Q96LU9	Gene names	ANKRD29
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 29.

ANR50_HUMAN
NC score	0.645332 (rank : 7)	θ value	5.26297e-08 (rank : 59)
Query Neighborhood Hits	371	Target Neighborhood Hits	361	Shared Neighborhood Hits	274
SwissProt Accessions	Q9ULJ7, Q6N064, Q6ZSE6	Gene names	ANKRD50, KIAA1223
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 50.

TNKS2_HUMAN
NC score	0.638601 (rank : 8)	θ value	6.64225e-11 (rank : 34)
Query Neighborhood Hits	371	Target Neighborhood Hits	361	Shared Neighborhood Hits	273
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

FANK1_HUMAN
NC score	0.638310 (rank : 9)	θ value	1.99992e-07 (rank : 72)
Query Neighborhood Hits	371	Target Neighborhood Hits	326	Shared Neighborhood Hits	265
SwissProt Accessions	Q8TC84, Q6UXY9, Q6X7T6	Gene names	FANK1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains protein 1.

FANK1_MOUSE
NC score	0.637961 (rank : 10)	θ value	1.17247e-07 (rank : 68)
Query Neighborhood Hits	371	Target Neighborhood Hits	325	Shared Neighborhood Hits	264
SwissProt Accessions	Q9DAM9, Q9CUA7	Gene names	Fank1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains 1 protein (Germ cell- specific gene 1 protein) (GSG1).

ANKR6_HUMAN
NC score	0.636767 (rank : 11)	θ value	1.43324e-05 (rank : 117)
Query Neighborhood Hits	371	Target Neighborhood Hits	439	Shared Neighborhood Hits	274
SwissProt Accessions	Q9Y2G4, Q9NU24, Q9UFQ9	Gene names	ANKRD6, KIAA0957
Domain Architecture
Description	Ankyrin repeat domain-containing protein 6.

ASB8_MOUSE
NC score	0.636411 (rank : 12)	θ value	4.45536e-07 (rank : 79)
Query Neighborhood Hits	371	Target Neighborhood Hits	293	Shared Neighborhood Hits	267
SwissProt Accessions	Q91ZT9, Q8R178	Gene names	Asb8
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 8 (ASB-8).

ASB8_HUMAN
NC score	0.636380 (rank : 13)	θ value	4.45536e-07 (rank : 78)
Query Neighborhood Hits	371	Target Neighborhood Hits	294	Shared Neighborhood Hits	268
SwissProt Accessions	Q9H765, Q547Q2	Gene names	ASB8
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 8 (ASB-8).

ANKR2_MOUSE
NC score	0.635785 (rank : 14)	θ value	1.87187e-05 (rank : 121)
Query Neighborhood Hits	371	Target Neighborhood Hits	312	Shared Neighborhood Hits	270
SwissProt Accessions	Q9WV06	Gene names	Ankrd2, Arpp
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (mArpp).

ANR42_MOUSE
NC score	0.635272 (rank : 15)	θ value	1.17247e-07 (rank : 65)
Query Neighborhood Hits	371	Target Neighborhood Hits	334	Shared Neighborhood Hits	270
SwissProt Accessions	Q3V096, Q8BX55, Q8BZT3, Q8C0T6, Q8C0X5	Gene names	Ankrd42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

ANR28_MOUSE
NC score	0.634664 (rank : 16)	θ value	1.06045e-08 (rank : 46)
Query Neighborhood Hits	371	Target Neighborhood Hits	314	Shared Neighborhood Hits	272
SwissProt Accessions	Q505D1	Gene names	Ankrd28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ANR44_HUMAN
NC score	0.634280 (rank : 17)	θ value	3.08544e-08 (rank : 55)
Query Neighborhood Hits	371	Target Neighborhood Hits	318	Shared Neighborhood Hits	272
SwissProt Accessions	Q8N8A2, Q6P480, Q86VL5, Q8IZ72, Q9UFA4	Gene names	ANKRD44
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 44.

ANR28_HUMAN
NC score	0.634110 (rank : 18)	θ value	1.06045e-08 (rank : 45)
Query Neighborhood Hits	371	Target Neighborhood Hits	314	Shared Neighborhood Hits	272
SwissProt Accessions	O15084, Q6ULS0, Q6ZT57	Gene names	ANKRD28, KIAA0379
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

TNKS1_HUMAN
NC score	0.633431 (rank : 19)	θ value	2.13673e-09 (rank : 38)
Query Neighborhood Hits	371	Target Neighborhood Hits	477	Shared Neighborhood Hits	273
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

ANKR2_HUMAN
NC score	0.632456 (rank : 20)	θ value	2.44474e-05 (rank : 129)
Query Neighborhood Hits	371	Target Neighborhood Hits	321	Shared Neighborhood Hits	270
SwissProt Accessions	Q9GZV1, Q5T456, Q8WUD7	Gene names	ANKRD2, ARPP
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp).

MTPN_MOUSE
NC score	0.632187 (rank : 21)	θ value	0.000786445 (rank : 196)
Query Neighborhood Hits	371	Target Neighborhood Hits	269	Shared Neighborhood Hits	259
SwissProt Accessions	P62774, P80144, Q543M6, Q9DCN8	Gene names	Mtpn, Gcdp
Domain Architecture	No domain graphic available
Description	Myotrophin (Protein V-1) (Granule cell differentiation protein).

ANR23_MOUSE
NC score	0.630858 (rank : 22)	θ value	0.000158464 (rank : 162)
Query Neighborhood Hits	371	Target Neighborhood Hits	296	Shared Neighborhood Hits	268
SwissProt Accessions	Q812A3	Gene names	Ankrd23, Darp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein).

ASZ1_HUMAN
NC score	0.630554 (rank : 23)	θ value	1.69304e-06 (rank : 92)
Query Neighborhood Hits	371	Target Neighborhood Hits	341	Shared Neighborhood Hits	262
SwissProt Accessions	Q8WWH4	Gene names	ASZ1, GASZ
Domain Architecture
Description	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).

GABP2_MOUSE
NC score	0.630512 (rank : 24)	θ value	3.19293e-05 (rank : 136)
Query Neighborhood Hits	371	Target Neighborhood Hits	429	Shared Neighborhood Hits	269
SwissProt Accessions	Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2	Gene names	Gabpb2, Gabpb, Gabpb1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1).

MTPN_HUMAN
NC score	0.630468 (rank : 25)	θ value	0.000786445 (rank : 195)
Query Neighborhood Hits	371	Target Neighborhood Hits	269	Shared Neighborhood Hits	259
SwissProt Accessions	P58546	Gene names	MTPN
Domain Architecture
Description	Myotrophin (Protein V-1).

ASZ1_MOUSE
NC score	0.630199 (rank : 26)	θ value	3.77169e-06 (rank : 98)
Query Neighborhood Hits	371	Target Neighborhood Hits	319	Shared Neighborhood Hits	264
SwissProt Accessions	Q8VD46, Q9JKQ7	Gene names	Asz1, Gasz
Domain Architecture
Description	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).

ACBD6_MOUSE
NC score	0.630055 (rank : 27)	θ value	6.64225e-11 (rank : 33)
Query Neighborhood Hits	371	Target Neighborhood Hits	305	Shared Neighborhood Hits	269
SwissProt Accessions	Q9D061, Q3TMN7, Q9DCU4	Gene names	Acbd6
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 6.

GABP2_HUMAN
NC score	0.628982 (rank : 28)	θ value	2.44474e-05 (rank : 133)
Query Neighborhood Hits	371	Target Neighborhood Hits	454	Shared Neighborhood Hits	269
SwissProt Accessions	Q06547, Q06545, Q12940, Q12941, Q12942, Q8IYD0	Gene names	GABPB2, E4TF1B, GABPB, GABPB1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1) (Transcription factor E4TF1-53) (Transcription factor E4TF1-47) (Nuclear respiratory factor 2).

GABP3_MOUSE
NC score	0.628698 (rank : 29)	θ value	0.000121331 (rank : 160)
Query Neighborhood Hits	371	Target Neighborhood Hits	330	Shared Neighborhood Hits	263
SwissProt Accessions	P81069	Gene names	Gabpb2
Domain Architecture	No domain graphic available
Description	GA-binding protein beta-2-1 chain (GABP subunit beta-2-1) (GABPB2-1).

ANKS3_MOUSE
NC score	0.628494 (rank : 30)	θ value	3.41135e-07 (rank : 74)
Query Neighborhood Hits	371	Target Neighborhood Hits	355	Shared Neighborhood Hits	262
SwissProt Accessions	Q9CZK6, Q6ZPF6, Q80X46	Gene names	Anks3, Kiaa1977
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 3.

ANKR1_HUMAN
NC score	0.628480 (rank : 31)	θ value	1.87187e-05 (rank : 120)
Query Neighborhood Hits	371	Target Neighborhood Hits	308	Shared Neighborhood Hits	266
SwissProt Accessions	Q15327, Q96LE7	Gene names	ANKRD1, C193, CARP, HA1A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) (Cytokine-inducible nuclear protein) (C-193).

ASB3_MOUSE
NC score	0.628250 (rank : 32)	θ value	7.1131e-05 (rank : 150)
Query Neighborhood Hits	371	Target Neighborhood Hits	316	Shared Neighborhood Hits	270
SwissProt Accessions	Q9WV72	Gene names	Asb3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

ANR23_HUMAN
NC score	0.627410 (rank : 33)	θ value	0.000786445 (rank : 192)
Query Neighborhood Hits	371	Target Neighborhood Hits	291	Shared Neighborhood Hits	269
SwissProt Accessions	Q86SG2, Q711K7, Q8NAJ7	Gene names	ANKRD23, DARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein) (Muscle ankyrin repeat protein 3).

ANR52_MOUSE
NC score	0.626684 (rank : 34)	θ value	5.26297e-08 (rank : 60)
Query Neighborhood Hits	371	Target Neighborhood Hits	318	Shared Neighborhood Hits	273
SwissProt Accessions	Q8BTI7	Gene names	Ankrd52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ASB3_HUMAN
NC score	0.626363 (rank : 35)	θ value	7.1131e-05 (rank : 149)
Query Neighborhood Hits	371	Target Neighborhood Hits	316	Shared Neighborhood Hits	270
SwissProt Accessions	Q9Y575, Q9NVZ2	Gene names	ASB3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

ASB10_HUMAN
NC score	0.626032 (rank : 36)	θ value	5.44631e-05 (rank : 145)
Query Neighborhood Hits	371	Target Neighborhood Hits	291	Shared Neighborhood Hits	269
SwissProt Accessions	Q8WXI3	Gene names	ASB10
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

ANR16_HUMAN
NC score	0.625836 (rank : 37)	θ value	0.00134147 (rank : 197)
Query Neighborhood Hits	371	Target Neighborhood Hits	286	Shared Neighborhood Hits	266
SwissProt Accessions	Q6P6B7, Q9NT01	Gene names	ANKRD16
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 16.

ACBD6_HUMAN
NC score	0.625707 (rank : 38)	θ value	1.9326e-10 (rank : 36)
Query Neighborhood Hits	371	Target Neighborhood Hits	304	Shared Neighborhood Hits	267
SwissProt Accessions	Q9BR61	Gene names	ACBD6
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 6.

ASB10_MOUSE
NC score	0.625459 (rank : 39)	θ value	1.87187e-05 (rank : 125)
Query Neighborhood Hits	371	Target Neighborhood Hits	301	Shared Neighborhood Hits	270
SwissProt Accessions	Q91ZT7	Gene names	Asb10
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

ANKR5_MOUSE
NC score	0.625270 (rank : 40)	θ value	1.29631e-06 (rank : 90)
Query Neighborhood Hits	371	Target Neighborhood Hits	298	Shared Neighborhood Hits	265
SwissProt Accessions	Q9D2J7	Gene names	Ankrd5
Domain Architecture
Description	Ankyrin repeat domain-containing protein 5.

ANR52_HUMAN
NC score	0.625236 (rank : 41)	θ value	1.17247e-07 (rank : 66)
Query Neighborhood Hits	371	Target Neighborhood Hits	322	Shared Neighborhood Hits	273
SwissProt Accessions	Q8NB46	Gene names	ANKRD52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

CT086_HUMAN
NC score	0.624889 (rank : 42)	θ value	0.00509761 (rank : 226)
Query Neighborhood Hits	371	Target Neighborhood Hits	277	Shared Neighborhood Hits	258
SwissProt Accessions	Q9BZ19, Q4VXE6	Gene names	C20orf86
Domain Architecture
Description	Putative uncharacterized protein C20orf86.

ANKR1_MOUSE
NC score	0.624853 (rank : 43)	θ value	2.44474e-05 (rank : 128)
Query Neighborhood Hits	371	Target Neighborhood Hits	316	Shared Neighborhood Hits	271
SwissProt Accessions	Q9CR42, O55014, Q3UIF7, Q3UJ39, Q792Q9	Gene names	Ankrd1, Carp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein).

ANKS3_HUMAN
NC score	0.624847 (rank : 44)	θ value	2.61198e-07 (rank : 73)
Query Neighborhood Hits	371	Target Neighborhood Hits	355	Shared Neighborhood Hits	262
SwissProt Accessions	Q6ZW76, Q8TF25	Gene names	ANKS3, KIAA1977
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 3.

ANK1_HUMAN
NC score	0.624461 (rank : 45)	θ value	4.0297e-08 (rank : 56)
Query Neighborhood Hits	371	Target Neighborhood Hits	416	Shared Neighborhood Hits	273
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

ANKS6_HUMAN
NC score	0.624433 (rank : 46)	θ value	3.08544e-08 (rank : 54)
Query Neighborhood Hits	371	Target Neighborhood Hits	411	Shared Neighborhood Hits	267
SwissProt Accessions	Q68DC2, Q5VSL0, Q5VSL2, Q5VSL3, Q5VSL4, Q68DB8, Q6P2R2, Q8N9L6, Q96D62	Gene names	ANKS6, ANKRD14, SAMD6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6) (Ankyrin repeat domain-containing protein 14).

RFXK_HUMAN
NC score	0.623866 (rank : 47)	θ value	7.59969e-07 (rank : 82)
Query Neighborhood Hits	371	Target Neighborhood Hits	282	Shared Neighborhood Hits	254
SwissProt Accessions	O14593, O95839	Gene names	RFXANK, ANKRA1, RFXB
Domain Architecture
Description	DNA-binding protein RFXANK (Regulatory factor X subunit B) (RFX-B) (Ankyrin repeat family A protein 1).

ANRA2_HUMAN
NC score	0.623693 (rank : 48)	θ value	3.77169e-06 (rank : 97)
Query Neighborhood Hits	371	Target Neighborhood Hits	288	Shared Neighborhood Hits	260
SwissProt Accessions	Q9H9E1	Gene names	ANKRA2, ANKRA
Domain Architecture
Description	Ankyrin repeat family A protein 2 (RFXANK-like 2).

ANK1_MOUSE
NC score	0.623149 (rank : 49)	θ value	1.53129e-07 (rank : 69)
Query Neighborhood Hits	371	Target Neighborhood Hits	430	Shared Neighborhood Hits	273
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

ANRA2_MOUSE
NC score	0.623139 (rank : 50)	θ value	4.92598e-06 (rank : 102)
Query Neighborhood Hits	371	Target Neighborhood Hits	287	Shared Neighborhood Hits	260
SwissProt Accessions	Q99PE2	Gene names	Ankra2, Ankra
Domain Architecture
Description	Ankyrin repeat family A protein 2 (RFXANK-like 2).

ANR42_HUMAN
NC score	0.622685 (rank : 51)	θ value	0.0113563 (rank : 233)
Query Neighborhood Hits	371	Target Neighborhood Hits	284	Shared Neighborhood Hits	264
SwissProt Accessions	Q8N9B4, Q49A49	Gene names	ANKRD42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

ASB7_MOUSE
NC score	0.622453 (rank : 52)	θ value	5.44631e-05 (rank : 147)
Query Neighborhood Hits	371	Target Neighborhood Hits	296	Shared Neighborhood Hits	268
SwissProt Accessions	Q91ZU0	Gene names	Asb7
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 7 (ASB-7).

ASB7_HUMAN
NC score	0.622103 (rank : 53)	θ value	5.44631e-05 (rank : 146)
Query Neighborhood Hits	371	Target Neighborhood Hits	296	Shared Neighborhood Hits	268
SwissProt Accessions	Q9H672, Q7Z4S3	Gene names	ASB7
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 7 (ASB-7).

INVS_HUMAN
NC score	0.621722 (rank : 54)	θ value	9.29e-05 (rank : 157)
Query Neighborhood Hits	371	Target Neighborhood Hits	455	Shared Neighborhood Hits	271
SwissProt Accessions	Q9Y283, Q5W0T6, Q8IVX8, Q9BRB9, Q9Y488, Q9Y498	Gene names	INVS, INV, NPHP2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning homolog) (Nephrocystin-2).

CDN2C_HUMAN
NC score	0.621226 (rank : 55)	θ value	0.00509761 (rank : 225)
Query Neighborhood Hits	371	Target Neighborhood Hits	262	Shared Neighborhood Hits	253
SwissProt Accessions	P42773, Q8TB83	Gene names	CDKN2C, CDKN6
Domain Architecture
Description	Cyclin-dependent kinase 6 inhibitor (p18-INK6) (Cyclin-dependent kinase 4 inhibitor C) (p18-INK4c).

ANKS6_MOUSE
NC score	0.621138 (rank : 56)	θ value	9.92553e-07 (rank : 87)
Query Neighborhood Hits	371	Target Neighborhood Hits	435	Shared Neighborhood Hits	268
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

MYPT1_MOUSE
NC score	0.620562 (rank : 57)	θ value	8.97725e-08 (rank : 64)
Query Neighborhood Hits	371	Target Neighborhood Hits	539	Shared Neighborhood Hits	270
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

CDN2D_HUMAN
NC score	0.620182 (rank : 58)	θ value	0.000270298 (rank : 175)
Query Neighborhood Hits	371	Target Neighborhood Hits	268	Shared Neighborhood Hits	255
SwissProt Accessions	P55273, Q13102, Q6FGE9	Gene names	CDKN2D
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

ANK3_HUMAN
NC score	0.620072 (rank : 59)	θ value	4.0297e-08 (rank : 57)
Query Neighborhood Hits	371	Target Neighborhood Hits	853	Shared Neighborhood Hits	281
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

INVS_MOUSE
NC score	0.619491 (rank : 60)	θ value	7.1131e-05 (rank : 152)
Query Neighborhood Hits	371	Target Neighborhood Hits	609	Shared Neighborhood Hits	272
SwissProt Accessions	O89019, O88849	Gene names	Invs, Inv, Nphp2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning protein) (Nephrocystin-2).

ANKR5_HUMAN
NC score	0.618175 (rank : 61)	θ value	4.1701e-05 (rank : 139)
Query Neighborhood Hits	371	Target Neighborhood Hits	297	Shared Neighborhood Hits	265
SwissProt Accessions	Q9NU02, Q9H6Y9	Gene names	ANKRD5
Domain Architecture
Description	Ankyrin repeat domain-containing protein 5.

MIB1_HUMAN
NC score	0.617426 (rank : 62)	θ value	1.38499e-08 (rank : 49)
Query Neighborhood Hits	371	Target Neighborhood Hits	470	Shared Neighborhood Hits	275
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

MIB1_MOUSE
NC score	0.617230 (rank : 63)	θ value	1.38499e-08 (rank : 50)
Query Neighborhood Hits	371	Target Neighborhood Hits	471	Shared Neighborhood Hits	275
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

ASB2_HUMAN
NC score	0.616996 (rank : 64)	θ value	0.00020696 (rank : 169)
Query Neighborhood Hits	371	Target Neighborhood Hits	309	Shared Neighborhood Hits	269
SwissProt Accessions	Q96Q27, Q9NSU5, Q9Y567	Gene names	ASB2
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 2 (ASB-2).

TRPA1_MOUSE
NC score	0.616361 (rank : 65)	θ value	1.69304e-06 (rank : 93)
Query Neighborhood Hits	371	Target Neighborhood Hits	343	Shared Neighborhood Hits	273
SwissProt Accessions	Q8BLA8	Gene names	Trpa1, Anktm1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1).

ANR46_HUMAN
NC score	0.614971 (rank : 66)	θ value	0.00175202 (rank : 203)
Query Neighborhood Hits	371	Target Neighborhood Hits	281	Shared Neighborhood Hits	258
SwissProt Accessions	Q86W74, Q6P9B7	Gene names	ANKRD46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

CDN2C_MOUSE
NC score	0.614767 (rank : 67)	θ value	0.0736092 (rank : 258)
Query Neighborhood Hits	371	Target Neighborhood Hits	270	Shared Neighborhood Hits	256
SwissProt Accessions	Q60772	Gene names	Cdkn2c
Domain Architecture
Description	Cyclin-dependent kinase 6 inhibitor (p18-INK6) (Cyclin-dependent kinase 4 inhibitor C) (p18-INK4c).

ANR46_MOUSE
NC score	0.614742 (rank : 68)	θ value	0.00228821 (rank : 212)
Query Neighborhood Hits	371	Target Neighborhood Hits	274	Shared Neighborhood Hits	253
SwissProt Accessions	Q8BTZ5, Q1LZK9, Q8BV97	Gene names	Ankrd46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

RFXK_MOUSE
NC score	0.614392 (rank : 69)	θ value	3.77169e-06 (rank : 99)
Query Neighborhood Hits	371	Target Neighborhood Hits	273	Shared Neighborhood Hits	257
SwissProt Accessions	Q9Z205	Gene names	Rfxank, Rfxb, Tvl1
Domain Architecture
Description	DNA-binding protein RFXANK (Regulatory factor X subunit B) (RFX-B) (Regulatory factor X-associated ankyrin-containing protein) (Ankyrin repeat-containing adapter protein Tvl-1).

CDN2D_MOUSE
NC score	0.614072 (rank : 70)	θ value	0.000602161 (rank : 189)
Query Neighborhood Hits	371	Target Neighborhood Hits	267	Shared Neighborhood Hits	252
SwissProt Accessions	Q60773, Q60794	Gene names	Cdkn2d
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

PA2G6_MOUSE
NC score	0.611233 (rank : 71)	θ value	9.29e-05 (rank : 158)
Query Neighborhood Hits	371	Target Neighborhood Hits	293	Shared Neighborhood Hits	268
SwissProt Accessions	P97819, Q99LA9, Q9JK61	Gene names	Pla2g6
Domain Architecture
Description	85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4) (iPLA2) (CaI- PLA2) (Group VI phospholipase A2) (GVI PLA2).

MIB2_HUMAN
NC score	0.610474 (rank : 72)	θ value	5.81887e-07 (rank : 81)
Query Neighborhood Hits	371	Target Neighborhood Hits	438	Shared Neighborhood Hits	271
SwissProt Accessions	Q96AX9, Q7Z437, Q8IY62, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1	Gene names	MIB2, SKD, ZZANK1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N).

ASB2_MOUSE
NC score	0.610458 (rank : 73)	θ value	0.000786445 (rank : 193)
Query Neighborhood Hits	371	Target Neighborhood Hits	321	Shared Neighborhood Hits	268
SwissProt Accessions	Q8K0L0, Q9CTH4, Q9WV73	Gene names	Asb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 2 (ASB-2).

ANR10_HUMAN
NC score	0.610359 (rank : 74)	θ value	1.87187e-05 (rank : 123)
Query Neighborhood Hits	371	Target Neighborhood Hits	289	Shared Neighborhood Hits	257
SwissProt Accessions	Q9NXR5	Gene names	ANKRD10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

ANR10_MOUSE
NC score	0.609810 (rank : 75)	θ value	1.87187e-05 (rank : 124)
Query Neighborhood Hits	371	Target Neighborhood Hits	273	Shared Neighborhood Hits	256
SwissProt Accessions	Q99LW0	Gene names	Ankrd10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

TRPA1_HUMAN
NC score	0.609028 (rank : 76)	θ value	0.000461057 (rank : 188)
Query Neighborhood Hits	371	Target Neighborhood Hits	339	Shared Neighborhood Hits	271
SwissProt Accessions	O75762	Gene names	TRPA1, ANKTM1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation sensitive-protein p120).

PA2G6_HUMAN
NC score	0.608732 (rank : 77)	θ value	6.43352e-06 (rank : 108)
Query Neighborhood Hits	371	Target Neighborhood Hits	284	Shared Neighborhood Hits	264
SwissProt Accessions	O60733, O75645, Q8N452, Q9UG29, Q9UIT0, Q9Y671	Gene names	PLA2G6, IPLA2
Domain Architecture
Description	85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4) (iPLA2) (CaI- PLA2) (Group VI phospholipase A2) (GVI PLA2).

MIB2_MOUSE
NC score	0.608378 (rank : 78)	θ value	4.45536e-07 (rank : 80)
Query Neighborhood Hits	371	Target Neighborhood Hits	409	Shared Neighborhood Hits	268
SwissProt Accessions	Q8R516, Q52QU8, Q6PEF6, Q8C1N7, Q8VIB4	Gene names	Mib2, Skd
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) (Dystrophin-like protein) (Dyslike).

MYPT1_HUMAN
NC score	0.607745 (rank : 79)	θ value	8.97725e-08 (rank : 63)
Query Neighborhood Hits	371	Target Neighborhood Hits	723	Shared Neighborhood Hits	271
SwissProt Accessions	O14974, Q86WU3, Q8NFR6, Q9BYH0	Gene names	PPP1R12A, MBS, MYPT1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit).

ANS4B_HUMAN
NC score	0.607207 (rank : 80)	θ value	1.06045e-08 (rank : 47)
Query Neighborhood Hits	371	Target Neighborhood Hits	289	Shared Neighborhood Hits	254
SwissProt Accessions	Q8N8V4	Gene names	ANKS4B, HARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

ASB15_HUMAN
NC score	0.606768 (rank : 81)	θ value	1.17247e-07 (rank : 67)
Query Neighborhood Hits	371	Target Neighborhood Hits	305	Shared Neighborhood Hits	265
SwissProt Accessions	Q8WXK1	Gene names	ASB15
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 15 (ASB-15).

USH1G_HUMAN
NC score	0.606195 (rank : 82)	θ value	7.59969e-07 (rank : 83)
Query Neighborhood Hits	371	Target Neighborhood Hits	267	Shared Neighborhood Hits	253
SwissProt Accessions	Q495M9, Q8N251	Gene names	USH1G, SANS
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein (Scaffold protein containing ankyrin repeats and SAM domain).

USH1G_MOUSE
NC score	0.606174 (rank : 83)	θ value	7.59969e-07 (rank : 84)
Query Neighborhood Hits	371	Target Neighborhood Hits	271	Shared Neighborhood Hits	253
SwissProt Accessions	Q80T11, Q80UG0	Gene names	Ush1g, Sans
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein homolog (Scaffold protein containing ankyrin repeats and SAM domain) (Jackson shaker protein).

BCL3_HUMAN
NC score	0.604611 (rank : 84)	θ value	0.00035302 (rank : 180)
Query Neighborhood Hits	371	Target Neighborhood Hits	324	Shared Neighborhood Hits	267
SwissProt Accessions	P20749	Gene names	BCL3
Domain Architecture
Description	B-cell lymphoma 3-encoded protein (Protein Bcl-3).

ANR49_MOUSE
NC score	0.604610 (rank : 85)	θ value	0.365318 (rank : 281)
Query Neighborhood Hits	371	Target Neighborhood Hits	285	Shared Neighborhood Hits	263
SwissProt Accessions	Q8VE42, Q9Z2S1	Gene names	Ankrd49, Fgif, Gbif
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor) (Fetal globin-increasing factor).

PP16A_MOUSE
NC score	0.604433 (rank : 86)	θ value	0.00228821 (rank : 217)
Query Neighborhood Hits	371	Target Neighborhood Hits	318	Shared Neighborhood Hits	270
SwissProt Accessions	Q923M0, Q4V9Z1	Gene names	Ppp1r16a, Mypt3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase targeting subunit 3).

BCL3_MOUSE
NC score	0.604078 (rank : 87)	θ value	0.000158464 (rank : 163)
Query Neighborhood Hits	371	Target Neighborhood Hits	388	Shared Neighborhood Hits	268
SwissProt Accessions	Q9Z2F6	Gene names	Bcl3
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 3-encoded protein homolog (Protein Bcl-3).

ASB13_MOUSE
NC score	0.603811 (rank : 88)	θ value	0.000270298 (rank : 174)
Query Neighborhood Hits	371	Target Neighborhood Hits	293	Shared Neighborhood Hits	263
SwissProt Accessions	Q8VBX0	Gene names	Asb13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 13 (ASB-13).

MYPT2_HUMAN
NC score	0.603620 (rank : 89)	θ value	1.87187e-05 (rank : 126)
Query Neighborhood Hits	371	Target Neighborhood Hits	707	Shared Neighborhood Hits	274
SwissProt Accessions	O60237, Q8N179, Q9HCB7, Q9HCB8	Gene names	PPP1R12B, MYPT2
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase- targeting subunit 2) (Myosin phosphatase target subunit 2).

ASB13_HUMAN
NC score	0.603183 (rank : 90)	θ value	0.00035302 (rank : 178)
Query Neighborhood Hits	371	Target Neighborhood Hits	293	Shared Neighborhood Hits	264
SwissProt Accessions	Q8WXK3, Q96EP7, Q9H8Z1	Gene names	ASB13
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 13 (ASB-13).

ANR49_HUMAN
NC score	0.601942 (rank : 91)	θ value	0.813845 (rank : 295)
Query Neighborhood Hits	371	Target Neighborhood Hits	282	Shared Neighborhood Hits	264
SwissProt Accessions	Q8WVL7, Q8NDF2, Q96JE5, Q9NXK7	Gene names	ANKRD49, FGIF
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor).

ASB14_MOUSE
NC score	0.600702 (rank : 92)	θ value	1.09739e-05 (rank : 114)
Query Neighborhood Hits	371	Target Neighborhood Hits	293	Shared Neighborhood Hits	260
SwissProt Accessions	Q8VHS7	Gene names	Asb14
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 14 (ASB-14).

ANKS1_HUMAN
NC score	0.600449 (rank : 93)	θ value	1.87187e-05 (rank : 122)
Query Neighborhood Hits	371	Target Neighborhood Hits	438	Shared Neighborhood Hits	271
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

PP16B_HUMAN
NC score	0.600035 (rank : 94)	θ value	0.000461057 (rank : 187)
Query Neighborhood Hits	371	Target Neighborhood Hits	307	Shared Neighborhood Hits	268
SwissProt Accessions	Q96T49, O94912, Q9NQG4	Gene names	PPP1R16B, ANKRD4, KIAA0823
Domain Architecture
Description	Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein) (hTIMAP) (CAAX box protein TIMAP) (Ankyrin repeat domain protein 4).

BARD1_HUMAN
NC score	0.599539 (rank : 95)	θ value	2.44474e-05 (rank : 131)
Query Neighborhood Hits	371	Target Neighborhood Hits	427	Shared Neighborhood Hits	268
SwissProt Accessions	Q99728, O43574	Gene names	BARD1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

ASB16_MOUSE
NC score	0.599289 (rank : 96)	θ value	0.0148317 (rank : 236)
Query Neighborhood Hits	371	Target Neighborhood Hits	306	Shared Neighborhood Hits	265
SwissProt Accessions	Q8VHS5, Q8BYT0	Gene names	Asb16
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 16 (ASB-16).

PP16B_MOUSE
NC score	0.598111 (rank : 97)	θ value	0.00175202 (rank : 209)
Query Neighborhood Hits	371	Target Neighborhood Hits	302	Shared Neighborhood Hits	268
SwissProt Accessions	Q8VHQ3	Gene names	Ppp1r16b
Domain Architecture
Description	Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein) (CAAX box protein TIMAP).

ANS4B_MOUSE
NC score	0.597826 (rank : 98)	θ value	1.80886e-08 (rank : 51)
Query Neighborhood Hits	371	Target Neighborhood Hits	294	Shared Neighborhood Hits	249
SwissProt Accessions	Q8K3X6, Q9D8A5	Gene names	Anks4b, Harp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

UBE3A_HUMAN
NC score	0.596869 (rank : 99)	θ value	9.54697e-26 (rank : 3)
Query Neighborhood Hits	371	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

ASB15_MOUSE
NC score	0.596564 (rank : 100)	θ value	4.92598e-06 (rank : 103)
Query Neighborhood Hits	371	Target Neighborhood Hits	292	Shared Neighborhood Hits	259
SwissProt Accessions	Q8VHS6	Gene names	Asb15
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 15 (ASB-15).

PP16A_HUMAN
NC score	0.596294 (rank : 101)	θ value	0.0113563 (rank : 234)
Query Neighborhood Hits	371	Target Neighborhood Hits	340	Shared Neighborhood Hits	265
SwissProt Accessions	Q96I34	Gene names	PPP1R16A, MYPT3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase- targeting subunit 3).

BARD1_MOUSE
NC score	0.596089 (rank : 102)	θ value	4.1701e-05 (rank : 140)
Query Neighborhood Hits	371	Target Neighborhood Hits	411	Shared Neighborhood Hits	265
SwissProt Accessions	O70445	Gene names	Bard1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

ASB16_HUMAN
NC score	0.594990 (rank : 103)	θ value	0.00869519 (rank : 229)
Query Neighborhood Hits	371	Target Neighborhood Hits	286	Shared Neighborhood Hits	259
SwissProt Accessions	Q96NS5, Q8WXK0	Gene names	ASB16
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 16 (ASB-16).

RN5A_HUMAN
NC score	0.594239 (rank : 104)	θ value	0.000158464 (rank : 166)
Query Neighborhood Hits	371	Target Neighborhood Hits	608	Shared Neighborhood Hits	268
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

ANR41_HUMAN
NC score	0.593637 (rank : 105)	θ value	1.09739e-05 (rank : 113)
Query Neighborhood Hits	371	Target Neighborhood Hits	332	Shared Neighborhood Hits	244
SwissProt Accessions	Q8NAG6, Q8N8J8	Gene names	ANKRD41
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 41.

ASB1_HUMAN
NC score	0.593580 (rank : 106)	θ value	3.19293e-05 (rank : 134)
Query Neighborhood Hits	371	Target Neighborhood Hits	291	Shared Neighborhood Hits	259
SwissProt Accessions	Q9Y576, Q9ULS4	Gene names	ASB1, KIAA1146
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 1 (ASB-1).

TRIPC_HUMAN
NC score	0.593067 (rank : 107)	θ value	9.18288e-45 (rank : 2)
Query Neighborhood Hits	371	Target Neighborhood Hits	319	Shared Neighborhood Hits	43
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

UBE3A_MOUSE
NC score	0.591843 (rank : 108)	θ value	2.20094e-22 (rank : 14)
Query Neighborhood Hits	371	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

ASB1_MOUSE
NC score	0.591815 (rank : 109)	θ value	1.43324e-05 (rank : 118)
Query Neighborhood Hits	371	Target Neighborhood Hits	292	Shared Neighborhood Hits	257
SwissProt Accessions	Q9WV74	Gene names	Asb1
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 1 (ASB-1).

ANKS1_MOUSE
NC score	0.588914 (rank : 110)	θ value	0.000270298 (rank : 173)
Query Neighborhood Hits	371	Target Neighborhood Hits	453	Shared Neighborhood Hits	270
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

CSKI1_HUMAN
NC score	0.588336 (rank : 111)	θ value	3.41135e-07 (rank : 75)
Query Neighborhood Hits	371	Target Neighborhood Hits	997	Shared Neighborhood Hits	277
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

UBE3C_HUMAN
NC score	0.588085 (rank : 112)	θ value	5.79196e-23 (rank : 11)
Query Neighborhood Hits	371	Target Neighborhood Hits	51	Shared Neighborhood Hits	35
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

EHMT1_HUMAN
NC score	0.588081 (rank : 113)	θ value	2.44474e-05 (rank : 132)
Query Neighborhood Hits	371	Target Neighborhood Hits	417	Shared Neighborhood Hits	270
SwissProt Accessions	Q9H9B1, Q8TCN7, Q96F53, Q96JF1, Q96KH4	Gene names	EHMT1, EUHMTASE1, KIAA1876
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a- like protein 1) (GLP1).

CSKI1_MOUSE
NC score	0.587973 (rank : 114)	θ value	3.41135e-07 (rank : 76)
Query Neighborhood Hits	371	Target Neighborhood Hits	1031	Shared Neighborhood Hits	277
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

UBE3C_MOUSE
NC score	0.587322 (rank : 115)	θ value	1.6852e-22 (rank : 13)
Query Neighborhood Hits	371	Target Neighborhood Hits	48	Shared Neighborhood Hits	35
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

CSKI2_HUMAN
NC score	0.586322 (rank : 116)	θ value	4.92598e-06 (rank : 104)
Query Neighborhood Hits	371	Target Neighborhood Hits	747	Shared Neighborhood Hits	274
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CSKI2_MOUSE
NC score	0.585653 (rank : 117)	θ value	8.40245e-06 (rank : 110)
Query Neighborhood Hits	371	Target Neighborhood Hits	812	Shared Neighborhood Hits	273
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

IKBA_HUMAN
NC score	0.585041 (rank : 118)	θ value	0.00228821 (rank : 214)
Query Neighborhood Hits	371	Target Neighborhood Hits	280	Shared Neighborhood Hits	258
SwissProt Accessions	P25963	Gene names	NFKBIA, IKBA, MAD3, NFKBI
Domain Architecture
Description	NF-kappa-B inhibitor alpha (Major histocompatibility complex enhancer- binding protein MAD3) (I-kappa-B-alpha) (IkappaBalpha) (IKB-alpha).

ANK2_HUMAN
NC score	0.583458 (rank : 119)	θ value	2.36244e-08 (rank : 53)
Query Neighborhood Hits	371	Target Neighborhood Hits	1615	Shared Neighborhood Hits	289
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

ANR35_HUMAN
NC score	0.582193 (rank : 120)	θ value	6.87365e-08 (rank : 62)
Query Neighborhood Hits	371	Target Neighborhood Hits	784	Shared Neighborhood Hits	273
SwissProt Accessions	Q8N283, Q3MJ10, Q96LS3	Gene names	ANKRD35
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 35.

EHMT2_HUMAN
NC score	0.580843 (rank : 121)	θ value	4.1701e-05 (rank : 141)
Query Neighborhood Hits	371	Target Neighborhood Hits	498	Shared Neighborhood Hits	272
SwissProt Accessions	Q96KQ7, Q14349, Q6PK06, Q96MH5, Q96QD0, Q9UQL8, Q9Y331	Gene names	EHMT2, BAT8, G9A, NG36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

ASB12_MOUSE
NC score	0.580200 (rank : 122)	θ value	0.00390308 (rank : 219)
Query Neighborhood Hits	371	Target Neighborhood Hits	261	Shared Neighborhood Hits	251
SwissProt Accessions	Q9D738	Gene names	Asb12
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 12 (ASB-12).

HECD2_MOUSE
NC score	0.580139 (rank : 123)	θ value	1.058e-16 (rank : 23)
Query Neighborhood Hits	371	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_HUMAN
NC score	0.579681 (rank : 124)	θ value	9.56915e-18 (rank : 20)
Query Neighborhood Hits	371	Target Neighborhood Hits	41	Shared Neighborhood Hits	34
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

ANKR7_HUMAN
NC score	0.578547 (rank : 125)	θ value	0.365318 (rank : 276)
Query Neighborhood Hits	371	Target Neighborhood Hits	286	Shared Neighborhood Hits	260
SwissProt Accessions	Q92527, Q96QN1, Q9UDM3	Gene names	ANKRD7
Domain Architecture
Description	Ankyrin repeat domain-containing protein 7 (Testis-specific protein TSA806).

ASB12_HUMAN
NC score	0.576769 (rank : 126)	θ value	0.0330416 (rank : 248)
Query Neighborhood Hits	371	Target Neighborhood Hits	263	Shared Neighborhood Hits	252
SwissProt Accessions	Q8WXK4, Q52LK4, Q6ISF9	Gene names	ASB12
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 12 (ASB-12).

ANR22_HUMAN
NC score	0.576679 (rank : 127)	θ value	0.47712 (rank : 282)
Query Neighborhood Hits	371	Target Neighborhood Hits	243	Shared Neighborhood Hits	230
SwissProt Accessions	Q5VYY1, Q8WU06	Gene names	ANKRD22
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 22.

IKBE_MOUSE
NC score	0.575264 (rank : 128)	θ value	0.0193708 (rank : 241)
Query Neighborhood Hits	371	Target Neighborhood Hits	308	Shared Neighborhood Hits	260
SwissProt Accessions	O54910, Q3U686, Q9CZZ9, Q9D7U3	Gene names	Nfkbie, Ikbe
Domain Architecture
Description	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKB-E).

IKBA_MOUSE
NC score	0.575062 (rank : 129)	θ value	0.000786445 (rank : 194)
Query Neighborhood Hits	371	Target Neighborhood Hits	283	Shared Neighborhood Hits	258
SwissProt Accessions	Q9Z1E3, Q80ZX5	Gene names	Nfkbia, Ikba
Domain Architecture	No domain graphic available
Description	NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkappaBalpha) (IKB- alpha).

ANKY2_HUMAN
NC score	0.574158 (rank : 130)	θ value	0.00020696 (rank : 168)
Query Neighborhood Hits	371	Target Neighborhood Hits	306	Shared Neighborhood Hits	249
SwissProt Accessions	Q8IV38, Q96BL3	Gene names	ANKMY2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and MYND domain-containing protein 2.

ASB4_MOUSE
NC score	0.573486 (rank : 131)	θ value	0.00020696 (rank : 170)
Query Neighborhood Hits	371	Target Neighborhood Hits	265	Shared Neighborhood Hits	251
SwissProt Accessions	Q9WV71	Gene names	Asb4
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 4 (ASB-4).

ASB4_HUMAN
NC score	0.572915 (rank : 132)	θ value	0.00035302 (rank : 179)
Query Neighborhood Hits	371	Target Neighborhood Hits	264	Shared Neighborhood Hits	251
SwissProt Accessions	Q9Y574, O14586	Gene names	ASB4
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 4 (ASB-4).

AN36B_HUMAN
NC score	0.571359 (rank : 133)	θ value	0.0148317 (rank : 235)
Query Neighborhood Hits	371	Target Neighborhood Hits	294	Shared Neighborhood Hits	262
SwissProt Accessions	Q8N2N9, Q6IPR0	Gene names	ANKRD36B
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 36B.

EHMT2_MOUSE
NC score	0.570778 (rank : 134)	θ value	9.29e-05 (rank : 155)
Query Neighborhood Hits	371	Target Neighborhood Hits	750	Shared Neighborhood Hits	277
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

ASB11_MOUSE
NC score	0.570226 (rank : 135)	θ value	0.00509761 (rank : 223)
Query Neighborhood Hits	371	Target Neighborhood Hits	271	Shared Neighborhood Hits	249
SwissProt Accessions	Q9CQ31, Q3UJ13, Q9D0V1	Gene names	Asb11
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 11 (ASB-11).

ASB11_HUMAN
NC score	0.568233 (rank : 136)	θ value	0.0330416 (rank : 247)
Query Neighborhood Hits	371	Target Neighborhood Hits	271	Shared Neighborhood Hits	249
SwissProt Accessions	Q8WXH4, Q3SYC4	Gene names	ASB11
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 11 (ASB-11).

IKBB_MOUSE
NC score	0.566736 (rank : 137)	θ value	0.00175202 (rank : 208)
Query Neighborhood Hits	371	Target Neighborhood Hits	284	Shared Neighborhood Hits	263
SwissProt Accessions	Q60778, Q9D6L5	Gene names	Nfkbib, Ikbb
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B).

ITCH_MOUSE
NC score	0.566360 (rank : 138)	θ value	6.84181e-24 (rank : 7)
Query Neighborhood Hits	371	Target Neighborhood Hits	127	Shared Neighborhood Hits	34
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

ASB9_HUMAN
NC score	0.565493 (rank : 139)	θ value	0.125558 (rank : 267)
Query Neighborhood Hits	371	Target Neighborhood Hits	267	Shared Neighborhood Hits	248
SwissProt Accessions	Q96DX5, Q9NWS5, Q9Y4T3	Gene names	ASB9
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 9 (ASB-9).

K0317_HUMAN
NC score	0.564776 (rank : 140)	θ value	2.20605e-14 (rank : 27)
Query Neighborhood Hits	371	Target Neighborhood Hits	46	Shared Neighborhood Hits	35
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

WWP2_HUMAN
NC score	0.564506 (rank : 141)	θ value	6.18819e-25 (rank : 4)
Query Neighborhood Hits	371	Target Neighborhood Hits	177	Shared Neighborhood Hits	38
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

K0317_MOUSE
NC score	0.563952 (rank : 142)	θ value	4.91457e-14 (rank : 28)
Query Neighborhood Hits	371	Target Neighborhood Hits	43	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

IKBB_HUMAN
NC score	0.563667 (rank : 143)	θ value	0.000461057 (rank : 185)
Query Neighborhood Hits	371	Target Neighborhood Hits	284	Shared Neighborhood Hits	261
SwissProt Accessions	Q15653, Q96BJ7	Gene names	NFKBIB, IKBB, TRIP9
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9).

WWP1_MOUSE
NC score	0.563312 (rank : 144)	θ value	8.08199e-25 (rank : 6)
Query Neighborhood Hits	371	Target Neighborhood Hits	138	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP2_MOUSE
NC score	0.563211 (rank : 145)	θ value	6.84181e-24 (rank : 8)
Query Neighborhood Hits	371	Target Neighborhood Hits	118	Shared Neighborhood Hits	33
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

IKBE_HUMAN
NC score	0.562051 (rank : 146)	θ value	0.0431538 (rank : 251)
Query Neighborhood Hits	371	Target Neighborhood Hits	288	Shared Neighborhood Hits	256
SwissProt Accessions	O00221	Gene names	NFKBIE, IKBE
Domain Architecture
Description	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKBE).

ZDH17_HUMAN
NC score	0.561685 (rank : 147)	θ value	7.59969e-07 (rank : 85)
Query Neighborhood Hits	371	Target Neighborhood Hits	334	Shared Neighborhood Hits	266
SwissProt Accessions	Q8IUH5, O75407, Q7Z2I0, Q86W89, Q86YK0, Q9P088, Q9UPZ8	Gene names	ZDHHC17, HIP14, HIP3, KIAA0946
Domain Architecture
Description	Palmitoyltransferase ZDHHC17 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 17) (DHHC-17) (Huntingtin-interacting protein 14) (Huntingtin-interacting protein 3) (Huntingtin-interacting protein HYPH) (Putative NF-kappa-B-activating protein 205) (Putative MAPK- activating protein PM11).

ANR15_HUMAN
NC score	0.561246 (rank : 148)	θ value	3.77169e-06 (rank : 96)
Query Neighborhood Hits	371	Target Neighborhood Hits	478	Shared Neighborhood Hits	259
SwissProt Accessions	Q14678, Q5W0W0, Q8IY65, Q8WX74	Gene names	ANKRD15, KANK, KIAA0172
Domain Architecture
Description	Ankyrin repeat domain-containing protein 15 (Kidney ankyrin repeat- containing protein).

RN5A_MOUSE
NC score	0.560607 (rank : 149)	θ value	2.88788e-06 (rank : 94)
Query Neighborhood Hits	371	Target Neighborhood Hits	899	Shared Neighborhood Hits	269
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

ITCH_HUMAN
NC score	0.560570 (rank : 150)	θ value	1.6852e-22 (rank : 12)
Query Neighborhood Hits	371	Target Neighborhood Hits	162	Shared Neighborhood Hits	35
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

SMUF1_HUMAN
NC score	0.559128 (rank : 151)	θ value	6.85773e-16 (rank : 25)
Query Neighborhood Hits	371	Target Neighborhood Hits	135	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF2_HUMAN
NC score	0.558970 (rank : 152)	θ value	8.65492e-19 (rank : 18)
Query Neighborhood Hits	371	Target Neighborhood Hits	142	Shared Neighborhood Hits	34
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

WWP1_HUMAN
NC score	0.558530 (rank : 153)	θ value	8.08199e-25 (rank : 5)
Query Neighborhood Hits	371	Target Neighborhood Hits	262	Shared Neighborhood Hits	35
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

ZDH17_MOUSE
NC score	0.558339 (rank : 154)	θ value	7.59969e-07 (rank : 86)
Query Neighborhood Hits	371	Target Neighborhood Hits	328	Shared Neighborhood Hits	264
SwissProt Accessions	Q80TN5, Q8BJ08, Q8BYQ2, Q8BYQ6	Gene names	Zdhhc17, Hip14, Kiaa0946
Domain Architecture
Description	Palmitoyltransferase ZDHHC17 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 17) (DHHC-17) (Huntingtin-interacting protein 14).

ASB9_MOUSE
NC score	0.557389 (rank : 155)	θ value	0.21417 (rank : 274)
Query Neighborhood Hits	371	Target Neighborhood Hits	257	Shared Neighborhood Hits	242
SwissProt Accessions	Q91ZT8, Q9DAF7	Gene names	Asb9
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 9 (ASB-9).

ANR32_HUMAN
NC score	0.557196 (rank : 156)	θ value	0.00869519 (rank : 228)
Query Neighborhood Hits	371	Target Neighborhood Hits	270	Shared Neighborhood Hits	250
SwissProt Accessions	Q9BQI6	Gene names	ANKRD32
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 32.

SMUF1_MOUSE
NC score	0.557149 (rank : 157)	θ value	6.85773e-16 (rank : 26)
Query Neighborhood Hits	371	Target Neighborhood Hits	142	Shared Neighborhood Hits	35
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

HUWE1_HUMAN
NC score	0.556768 (rank : 158)	θ value	2.06002e-20 (rank : 15)
Query Neighborhood Hits	371	Target Neighborhood Hits	443	Shared Neighborhood Hits	52
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
NC score	0.556719 (rank : 159)	θ value	2.06002e-20 (rank : 16)
Query Neighborhood Hits	371	Target Neighborhood Hits	406	Shared Neighborhood Hits	47
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

ANKY2_MOUSE
NC score	0.556501 (rank : 160)	θ value	0.000461057 (rank : 183)
Query Neighborhood Hits	371	Target Neighborhood Hits	316	Shared Neighborhood Hits	248
SwissProt Accessions	Q3TPE9, Q8BK14, Q8BYW5, Q8R3N4, Q921J1	Gene names	Ankmy2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and MYND domain-containing protein 2.

ANR11_HUMAN
NC score	0.555894 (rank : 161)	θ value	4.92598e-06 (rank : 101)
Query Neighborhood Hits	371	Target Neighborhood Hits	1289	Shared Neighborhood Hits	274
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

ASB5_HUMAN
NC score	0.554483 (rank : 162)	θ value	6.88961 (rank : 347)
Query Neighborhood Hits	371	Target Neighborhood Hits	283	Shared Neighborhood Hits	256
SwissProt Accessions	Q8WWX0	Gene names	ASB5
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 5 (ASB-5).

ZDH13_HUMAN
NC score	0.554190 (rank : 163)	θ value	7.1131e-05 (rank : 153)
Query Neighborhood Hits	371	Target Neighborhood Hits	322	Shared Neighborhood Hits	268
SwissProt Accessions	Q8IUH4, Q7Z2D3, Q86VK2, Q9NV30, Q9NV99	Gene names	ZDHHC13, HIP14L, HIP3RP
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC13 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein) (Huntingtin- interacting protein HIP3RP) (Putative NF-kappa-B-activating protein 209) (Putative MAPK-activating protein PM03).

AN36A_HUMAN
NC score	0.553246 (rank : 164)	θ value	0.00509761 (rank : 221)
Query Neighborhood Hits	371	Target Neighborhood Hits	271	Shared Neighborhood Hits	256
SwissProt Accessions	Q6UX02, Q86X62	Gene names	ANKRD36, ANKRD36A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 36A.

ASB5_MOUSE
NC score	0.553073 (rank : 165)	θ value	3.0926 (rank : 324)
Query Neighborhood Hits	371	Target Neighborhood Hits	266	Shared Neighborhood Hits	248
SwissProt Accessions	Q9D1A4	Gene names	Asb5
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 5 (ASB-5).

CD2A1_MOUSE
NC score	0.552646 (rank : 166)	θ value	7.1131e-05 (rank : 151)
Query Neighborhood Hits	371	Target Neighborhood Hits	206	Shared Neighborhood Hits	199
SwissProt Accessions	P51480, O89088, P97510, P97937, Q6PEA2, Q78E39, Q78E57, Q792X7, Q9QWH6, Q9QWH7, Q9QWH8	Gene names	Cdkn2a, P16ink4a
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 2A, isoforms 1/2 (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4) (p16-INK4a).

ZDH13_MOUSE
NC score	0.551625 (rank : 167)	θ value	4.1701e-05 (rank : 143)
Query Neighborhood Hits	371	Target Neighborhood Hits	329	Shared Neighborhood Hits	269
SwissProt Accessions	Q9CWU2, Q3UK32, Q3UKV1	Gene names	Zdhhc13, Hip14l
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC13 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein).

ANFY1_HUMAN
NC score	0.551349 (rank : 168)	θ value	2.44474e-05 (rank : 127)
Query Neighborhood Hits	371	Target Neighborhood Hits	480	Shared Neighborhood Hits	271
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_MOUSE
NC score	0.550306 (rank : 169)	θ value	0.000121331 (rank : 159)
Query Neighborhood Hits	371	Target Neighborhood Hits	480	Shared Neighborhood Hits	273
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANR19_HUMAN
NC score	0.547313 (rank : 170)	θ value	0.0330416 (rank : 246)
Query Neighborhood Hits	371	Target Neighborhood Hits	276	Shared Neighborhood Hits	260
SwissProt Accessions	Q9H560	Gene names	ANKRD19
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 19.

ANR32_MOUSE
NC score	0.546890 (rank : 171)	θ value	0.365318 (rank : 277)
Query Neighborhood Hits	371	Target Neighborhood Hits	285	Shared Neighborhood Hits	250
SwissProt Accessions	Q8R3P9, Q5XK30, Q8BHY5, Q921Y9	Gene names	Ankrd32
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 32.

ANR47_MOUSE
NC score	0.546727 (rank : 172)	θ value	0.00134147 (rank : 198)
Query Neighborhood Hits	371	Target Neighborhood Hits	350	Shared Neighborhood Hits	251
SwissProt Accessions	Q9Z1P7	Gene names	Ankrd47, D17Ertd288e, Ng28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

BCOR_MOUSE
NC score	0.545020 (rank : 173)	θ value	1.09739e-05 (rank : 115)
Query Neighborhood Hits	371	Target Neighborhood Hits	521	Shared Neighborhood Hits	261
SwissProt Accessions	Q8CGN4, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3	Gene names	Bcor, Kiaa1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

ANR37_HUMAN
NC score	0.544080 (rank : 174)	θ value	0.365318 (rank : 278)
Query Neighborhood Hits	371	Target Neighborhood Hits	247	Shared Neighborhood Hits	239
SwissProt Accessions	Q7Z713	Gene names	ANKRD37, LPR2BP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37 (Low-density lipoprotein receptor-related protein 2-binding protein) (hLrp2bp).

POTE8_HUMAN
NC score	0.542661 (rank : 175)	θ value	0.163984 (rank : 273)
Query Neighborhood Hits	371	Target Neighborhood Hits	337	Shared Neighborhood Hits	268
SwissProt Accessions	Q6S8J7, Q6S8J6	Gene names	POTE8
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 8.

CTTB2_HUMAN
NC score	0.540455 (rank : 176)	θ value	0.00035302 (rank : 181)
Query Neighborhood Hits	371	Target Neighborhood Hits	1061	Shared Neighborhood Hits	277
SwissProt Accessions	Q8WZ74, O43389, Q7LG11, Q9C0A5	Gene names	CTTNBP2, C7orf8, CORTBP2, KIAA1758
Domain Architecture	No domain graphic available
Description	Cortactin-binding protein 2 (CortBP2).

BCOR_HUMAN
NC score	0.537812 (rank : 177)	θ value	1.43324e-05 (rank : 119)
Query Neighborhood Hits	371	Target Neighborhood Hits	609	Shared Neighborhood Hits	261
SwissProt Accessions	Q6W2J9, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2	Gene names	BCOR, KIAA1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

ANR12_HUMAN
NC score	0.536108 (rank : 178)	θ value	2.44474e-05 (rank : 130)
Query Neighborhood Hits	371	Target Neighborhood Hits	1081	Shared Neighborhood Hits	273
SwissProt Accessions	Q6UB98, O94951, Q658K1, Q6QMF7, Q9H231, Q9H784	Gene names	ANKRD12, ANCO2, KIAA0874
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein).

NEDD4_MOUSE
NC score	0.526236 (rank : 179)	θ value	2.7842e-17 (rank : 22)
Query Neighborhood Hits	371	Target Neighborhood Hits	212	Shared Neighborhood Hits	34
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

SNCAP_HUMAN
NC score	0.523613 (rank : 180)	θ value	0.00869519 (rank : 231)
Query Neighborhood Hits	371	Target Neighborhood Hits	313	Shared Neighborhood Hits	232
SwissProt Accessions	Q9Y6H5	Gene names	SNCAIP
Domain Architecture
Description	Synphilin-1 (Alpha-synuclein-interacting protein).

NEDD4_HUMAN
NC score	0.523249 (rank : 181)	θ value	1.24977e-17 (rank : 21)
Query Neighborhood Hits	371	Target Neighborhood Hits	214	Shared Neighborhood Hits	35
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

ANR47_HUMAN
NC score	0.523173 (rank : 182)	θ value	0.00509761 (rank : 222)
Query Neighborhood Hits	371	Target Neighborhood Hits	369	Shared Neighborhood Hits	246
SwissProt Accessions	Q6NY19, Q6NZI1, Q6ZQR3, Q8IUV2	Gene names	ANKRD47
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

KRIT1_MOUSE
NC score	0.521614 (rank : 183)	θ value	0.000158464 (rank : 164)
Query Neighborhood Hits	371	Target Neighborhood Hits	258	Shared Neighborhood Hits	225
SwissProt Accessions	Q6S5J6, Q6VSV2, Q7TPR8, Q8C9Q6, Q9EPY2, Q9ERH0	Gene names	Krit1, Ccm1
Domain Architecture	No domain graphic available
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog).

CLPB_MOUSE
NC score	0.519992 (rank : 184)	θ value	9.29e-05 (rank : 154)
Query Neighborhood Hits	371	Target Neighborhood Hits	289	Shared Neighborhood Hits	237
SwissProt Accessions	Q60649	Gene names	Clpb, Skd3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

NED4L_MOUSE
NC score	0.519353 (rank : 185)	θ value	2.59989e-23 (rank : 10)
Query Neighborhood Hits	371	Target Neighborhood Hits	231	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_HUMAN
NC score	0.518727 (rank : 186)	θ value	2.59989e-23 (rank : 9)
Query Neighborhood Hits	371	Target Neighborhood Hits	238	Shared Neighborhood Hits	34
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

ASB6_MOUSE
NC score	0.515750 (rank : 187)	θ value	0.0961366 (rank : 264)
Query Neighborhood Hits	371	Target Neighborhood Hits	264	Shared Neighborhood Hits	234
SwissProt Accessions	Q91ZU1, Q8VEC6	Gene names	Asb6
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 6 (ASB-6).

ANR37_MOUSE
NC score	0.514075 (rank : 188)	θ value	2.36792 (rank : 310)
Query Neighborhood Hits	371	Target Neighborhood Hits	237	Shared Neighborhood Hits	229
SwissProt Accessions	Q569N2, Q8CHS0	Gene names	Ankrd37
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37.

ASB6_HUMAN
NC score	0.513012 (rank : 189)	θ value	0.813845 (rank : 296)
Query Neighborhood Hits	371	Target Neighborhood Hits	256	Shared Neighborhood Hits	234
SwissProt Accessions	Q9NWX5	Gene names	ASB6
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 6 (ASB-6).

ANR21_HUMAN
NC score	0.512728 (rank : 190)	θ value	0.0252991 (rank : 242)
Query Neighborhood Hits	371	Target Neighborhood Hits	864	Shared Neighborhood Hits	273
SwissProt Accessions	Q86YR6	Gene names	ANKRD21, POTE
Domain Architecture
Description	Ankyrin repeat domain-containing protein 21 (Protein POTE) (Prostate, ovary, testis-expressed protein).

POT15_HUMAN
NC score	0.512559 (rank : 191)	θ value	0.0252991 (rank : 244)
Query Neighborhood Hits	371	Target Neighborhood Hits	893	Shared Neighborhood Hits	273
SwissProt Accessions	Q6S5H4, Q6NXN7, Q6S5H7	Gene names	POTE15
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 15.

SHAN1_HUMAN
NC score	0.510905 (rank : 192)	θ value	0.0148317 (rank : 238)
Query Neighborhood Hits	371	Target Neighborhood Hits	1041	Shared Neighborhood Hits	265
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

KRIT1_HUMAN
NC score	0.509615 (rank : 193)	θ value	0.00020696 (rank : 172)
Query Neighborhood Hits	371	Target Neighborhood Hits	258	Shared Neighborhood Hits	216
SwissProt Accessions	O00522, O43894, Q506L6, Q6U276, Q75N19, Q9H180, Q9H264, Q9HAX5	Gene names	KRIT1, CCM1
Domain Architecture
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein).

POT14_HUMAN
NC score	0.509523 (rank : 194)	θ value	0.00228821 (rank : 215)
Query Neighborhood Hits	371	Target Neighborhood Hits	403	Shared Neighborhood Hits	257
SwissProt Accessions	Q6S5H5, Q6S5H6, Q6S8J2	Gene names	POTE14
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 14.

ANR25_HUMAN
NC score	0.507518 (rank : 195)	θ value	0.00175202 (rank : 202)
Query Neighborhood Hits	371	Target Neighborhood Hits	350	Shared Neighborhood Hits	242
SwissProt Accessions	Q63ZY3, Q3KQZ3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210	Gene names	ANKRD25, KIAA1518, SIP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25 (SRC-1-interacting protein) (SRC1-interacting protein).

CDN2B_MOUSE
NC score	0.504054 (rank : 196)	θ value	0.0736092 (rank : 257)
Query Neighborhood Hits	371	Target Neighborhood Hits	201	Shared Neighborhood Hits	190
SwissProt Accessions	P55271	Gene names	Cdkn2b
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b).

NFKB1_MOUSE
NC score	0.502765 (rank : 197)	θ value	0.125558 (rank : 269)
Query Neighborhood Hits	371	Target Neighborhood Hits	300	Shared Neighborhood Hits	256
SwissProt Accessions	P25799, Q3TZE8, Q3V2V6, Q6TDG8, Q75ZL1, Q80Y21, Q8C712	Gene names	Nfkb1
Domain Architecture
Description	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) (NF-kappa-B1 p84/NF-kappa-B1 p98) [Contains: Nuclear factor NF- kappa-B p50 subunit].

NFKB1_HUMAN
NC score	0.501713 (rank : 198)	θ value	0.0961366 (rank : 265)
Query Neighborhood Hits	371	Target Neighborhood Hits	306	Shared Neighborhood Hits	263
SwissProt Accessions	P19838, Q68D84, Q86V43, Q8N4X7, Q9NZC0	Gene names	NFKB1
Domain Architecture
Description	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) [Contains: Nuclear factor NF-kappa-B p50 subunit].

MPP8_HUMAN
NC score	0.498425 (rank : 199)	θ value	0.000158464 (rank : 165)
Query Neighborhood Hits	371	Target Neighborhood Hits	948	Shared Neighborhood Hits	251
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

NFKB2_HUMAN
NC score	0.498231 (rank : 200)	θ value	0.279714 (rank : 275)
Query Neighborhood Hits	371	Target Neighborhood Hits	325	Shared Neighborhood Hits	263
SwissProt Accessions	Q00653, Q04860, Q9BU75, Q9H471, Q9H472	Gene names	NFKB2, LYT10
Domain Architecture
Description	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10) (Oncogene Lyt-10) (Lyt10) [Contains: Nuclear factor NF-kappa-B p52 subunit].

ANR25_MOUSE
NC score	0.495524 (rank : 201)	θ value	0.00228821 (rank : 211)
Query Neighborhood Hits	371	Target Neighborhood Hits	398	Shared Neighborhood Hits	241
SwissProt Accessions	Q8BX02, Q8BLD5, Q91Z35	Gene names	Ankrd25
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25.

CDN2B_HUMAN
NC score	0.495016 (rank : 202)	θ value	0.00228821 (rank : 213)
Query Neighborhood Hits	371	Target Neighborhood Hits	196	Shared Neighborhood Hits	190
SwissProt Accessions	P42772, Q6FI09	Gene names	CDKN2B, MTS2
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b) (p15INK4B) (Multiple tumor suppressor 2) (MTS2).

OSBL1_HUMAN
NC score	0.493646 (rank : 203)	θ value	0.000461057 (rank : 186)
Query Neighborhood Hits	371	Target Neighborhood Hits	368	Shared Neighborhood Hits	267
SwissProt Accessions	Q9BXW6, Q9BZF5, Q9NW87	Gene names	OSBPL1A, ORP1, OSBP8, OSBPL1
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

OSTF1_MOUSE
NC score	0.491562 (rank : 204)	θ value	3.19293e-05 (rank : 138)
Query Neighborhood Hits	371	Target Neighborhood Hits	467	Shared Neighborhood Hits	244
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

CD2A1_HUMAN
NC score	0.488532 (rank : 205)	θ value	0.0193708 (rank : 240)
Query Neighborhood Hits	371	Target Neighborhood Hits	196	Shared Neighborhood Hits	188
SwissProt Accessions	P42771, O95440, Q15191, Q5VVJ5, Q96B52, Q9NP05	Gene names	CDKN2A, CDKN2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4) (p16-INK4a) (p16INK4A) (Multiple tumor suppressor 1) (MTS1).

POT22_HUMAN
NC score	0.486619 (rank : 206)	θ value	0.00228821 (rank : 216)
Query Neighborhood Hits	371	Target Neighborhood Hits	266	Shared Neighborhood Hits	247
SwissProt Accessions	Q6S545	Gene names	ACTBL1, POTE22
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 22.

OSBL1_MOUSE
NC score	0.484797 (rank : 207)	θ value	0.000602161 (rank : 191)
Query Neighborhood Hits	371	Target Neighborhood Hits	336	Shared Neighborhood Hits	268
SwissProt Accessions	Q91XL9, O88318, Q3TH97, Q673L8, Q6DFU6	Gene names	Osbpl1a, Orp1, Orp1a
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

HERC3_HUMAN
NC score	0.483499 (rank : 208)	θ value	6.85773e-16 (rank : 24)
Query Neighborhood Hits	371	Target Neighborhood Hits	62	Shared Neighborhood Hits	35
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

ANR33_MOUSE
NC score	0.483108 (rank : 209)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	371	Target Neighborhood Hits	225	Shared Neighborhood Hits	219
SwissProt Accessions	Q8BXP5, Q8BXP4, Q8R1Z1	Gene names	Ankrd33
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

ANR33_HUMAN
NC score	0.480667 (rank : 210)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	371	Target Neighborhood Hits	215	Shared Neighborhood Hits	209
SwissProt Accessions	Q7Z3H0, Q5K619, Q5K621, Q5K622, Q5K623, Q5K624, Q6ZUN0	Gene names	ANKRD33, C12orf7
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

ANR38_HUMAN
NC score	0.480508 (rank : 211)	θ value	0.163984 (rank : 271)
Query Neighborhood Hits	371	Target Neighborhood Hits	443	Shared Neighborhood Hits	227
SwissProt Accessions	Q5T7N3, Q6P9A0, Q86T71, Q86VE6, Q8NAX3	Gene names	ANKRD38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

NFKB2_MOUSE
NC score	0.480080 (rank : 212)	θ value	1.81305 (rank : 304)
Query Neighborhood Hits	371	Target Neighborhood Hits	326	Shared Neighborhood Hits	259
SwissProt Accessions	Q9WTK5	Gene names	Nfkb2
Domain Architecture
Description	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) [Contains: Nuclear factor NF-kappa-B p52 subunit].

HERC5_HUMAN
NC score	0.478028 (rank : 213)	θ value	1.133e-10 (rank : 35)
Query Neighborhood Hits	371	Target Neighborhood Hits	66	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

OSTF1_HUMAN
NC score	0.474751 (rank : 214)	θ value	0.000121331 (rank : 161)
Query Neighborhood Hits	371	Target Neighborhood Hits	466	Shared Neighborhood Hits	243
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

A20A3_HUMAN
NC score	0.468271 (rank : 215)	θ value	0.0736092 (rank : 255)
Query Neighborhood Hits	371	Target Neighborhood Hits	692	Shared Neighborhood Hits	264
SwissProt Accessions	Q5VUR7	Gene names	ANKRD20A3
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A3.

A20A2_HUMAN
NC score	0.467534 (rank : 216)	θ value	0.0330416 (rank : 245)
Query Neighborhood Hits	371	Target Neighborhood Hits	716	Shared Neighborhood Hits	264
SwissProt Accessions	Q4UJ75	Gene names	ANKRD20A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A2.

A20A1_HUMAN
NC score	0.466874 (rank : 217)	θ value	0.0961366 (rank : 261)
Query Neighborhood Hits	371	Target Neighborhood Hits	698	Shared Neighborhood Hits	264
SwissProt Accessions	Q5TYW2, Q9H0H6	Gene names	ANKRD20A1, ANKRD20A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A1.

RAI14_HUMAN
NC score	0.465355 (rank : 218)	θ value	4.1701e-05 (rank : 142)
Query Neighborhood Hits	371	Target Neighborhood Hits	1367	Shared Neighborhood Hits	277
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

A20A4_HUMAN
NC score	0.464949 (rank : 219)	θ value	0.0736092 (rank : 256)
Query Neighborhood Hits	371	Target Neighborhood Hits	710	Shared Neighborhood Hits	264
SwissProt Accessions	Q5SQ80	Gene names	ANKRD20A4
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A4.

EDD1_MOUSE
NC score	0.461428 (rank : 220)	θ value	5.08577e-11 (rank : 32)
Query Neighborhood Hits	371	Target Neighborhood Hits	167	Shared Neighborhood Hits	34
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

EDD1_HUMAN
NC score	0.459930 (rank : 221)	θ value	5.08577e-11 (rank : 31)
Query Neighborhood Hits	371	Target Neighborhood Hits	170	Shared Neighborhood Hits	34
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

HECD3_MOUSE
NC score	0.459911 (rank : 222)	θ value	3.19293e-05 (rank : 137)
Query Neighborhood Hits	371	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

ANR38_MOUSE
NC score	0.458398 (rank : 223)	θ value	4.03905 (rank : 332)
Query Neighborhood Hits	371	Target Neighborhood Hits	512	Shared Neighborhood Hits	228
SwissProt Accessions	Q6P9J5, Q8BV03	Gene names	Ankrd38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

ABTB2_HUMAN
NC score	0.457351 (rank : 224)	θ value	4.92598e-06 (rank : 100)
Query Neighborhood Hits	371	Target Neighborhood Hits	391	Shared Neighborhood Hits	229
SwissProt Accessions	Q8N961, Q6MZW4, Q8NB44	Gene names	ABTB2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

HECD3_HUMAN
NC score	0.456308 (rank : 225)	θ value	9.29e-05 (rank : 156)
Query Neighborhood Hits	371	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

CENB5_HUMAN
NC score	0.454440 (rank : 226)	θ value	1.99992e-07 (rank : 71)
Query Neighborhood Hits	371	Target Neighborhood Hits	395	Shared Neighborhood Hits	253
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CLPB_HUMAN
NC score	0.454358 (rank : 227)	θ value	0.00665767 (rank : 227)
Query Neighborhood Hits	371	Target Neighborhood Hits	265	Shared Neighborhood Hits	223
SwissProt Accessions	Q9H078, Q8ND11, Q9H8Y0	Gene names	CLPB, SKD3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

ANR40_HUMAN
NC score	0.452419 (rank : 228)	θ value	0.0961366 (rank : 263)
Query Neighborhood Hits	371	Target Neighborhood Hits	224	Shared Neighborhood Hits	195
SwissProt Accessions	Q6AI12, Q96E32	Gene names	ANKRD40
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 40.

ANR43_HUMAN
NC score	0.449484 (rank : 229)	θ value	0.365318 (rank : 280)
Query Neighborhood Hits	371	Target Neighborhood Hits	209	Shared Neighborhood Hits	198
SwissProt Accessions	Q2M3V2, Q8NAE7	Gene names	ANKRD43
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 43.

HERC2_MOUSE
NC score	0.449229 (rank : 230)	θ value	8.65492e-19 (rank : 17)
Query Neighborhood Hits	371	Target Neighborhood Hits	167	Shared Neighborhood Hits	43
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

ABTB2_MOUSE
NC score	0.448708 (rank : 231)	θ value	6.43352e-06 (rank : 107)
Query Neighborhood Hits	371	Target Neighborhood Hits	414	Shared Neighborhood Hits	227
SwissProt Accessions	Q7TQI7	Gene names	Abtb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

CENB1_HUMAN
NC score	0.448654 (rank : 232)	θ value	8.40245e-06 (rank : 109)
Query Neighborhood Hits	371	Target Neighborhood Hits	383	Shared Neighborhood Hits	248
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

HERC2_HUMAN
NC score	0.446430 (rank : 233)	θ value	2.5182e-18 (rank : 19)
Query Neighborhood Hits	371	Target Neighborhood Hits	163	Shared Neighborhood Hits	41
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

CENB2_HUMAN
NC score	0.446188 (rank : 234)	θ value	1.99992e-07 (rank : 70)
Query Neighborhood Hits	371	Target Neighborhood Hits	425	Shared Neighborhood Hits	250
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

ANR40_MOUSE
NC score	0.443733 (rank : 235)	θ value	0.365318 (rank : 279)
Query Neighborhood Hits	371	Target Neighborhood Hits	228	Shared Neighborhood Hits	198
SwissProt Accessions	Q5SUE8, Q8R595, Q9CU71	Gene names	Ankrd40
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 40.

ANR43_MOUSE
NC score	0.442976 (rank : 236)	θ value	1.38821 (rank : 299)
Query Neighborhood Hits	371	Target Neighborhood Hits	214	Shared Neighborhood Hits	201
SwissProt Accessions	Q8BLS7	Gene names	Ankrd43
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 43.

RAI14_MOUSE
NC score	0.440922 (rank : 237)	θ value	1.09739e-05 (rank : 116)
Query Neighborhood Hits	371	Target Neighborhood Hits	1505	Shared Neighborhood Hits	278
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

GIT2_MOUSE
NC score	0.427980 (rank : 238)	θ value	0.00035302 (rank : 182)
Query Neighborhood Hits	371	Target Neighborhood Hits	323	Shared Neighborhood Hits	249
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

ANR18_HUMAN
NC score	0.426719 (rank : 239)	θ value	3.0926 (rank : 323)
Query Neighborhood Hits	371	Target Neighborhood Hits	1106	Shared Neighborhood Hits	266
SwissProt Accessions	Q8IVF6, Q7Z468	Gene names	ANKRD18A, KIAA2015
Domain Architecture
Description	Ankyrin repeat domain-containing protein 18A.

NUD12_MOUSE
NC score	0.416104 (rank : 240)	θ value	3.0926 (rank : 328)
Query Neighborhood Hits	371	Target Neighborhood Hits	243	Shared Neighborhood Hits	214
SwissProt Accessions	Q9DCN1, Q6PFA5	Gene names	Nudt12
Domain Architecture	No domain graphic available
Description	Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12).

GIT1_MOUSE
NC score	0.413497 (rank : 241)	θ value	0.00134147 (rank : 200)
Query Neighborhood Hits	371	Target Neighborhood Hits	341	Shared Neighborhood Hits	243
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

ASPP2_HUMAN
NC score	0.412440 (rank : 242)	θ value	0.00509761 (rank : 224)
Query Neighborhood Hits	371	Target Neighborhood Hits	1156	Shared Neighborhood Hits	266
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

GIT1_HUMAN
NC score	0.410951 (rank : 243)	θ value	0.00134147 (rank : 199)
Query Neighborhood Hits	371	Target Neighborhood Hits	336	Shared Neighborhood Hits	242
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

ANR45_MOUSE
NC score	0.407258 (rank : 244)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	371	Target Neighborhood Hits	204	Shared Neighborhood Hits	185
SwissProt Accessions	Q810N6	Gene names	Ankrd45
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 45.

AN30A_HUMAN
NC score	0.407023 (rank : 245)	θ value	0.0193708 (rank : 239)
Query Neighborhood Hits	371	Target Neighborhood Hits	1119	Shared Neighborhood Hits	264
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

ANKK1_HUMAN
NC score	0.405057 (rank : 246)	θ value	1.29631e-06 (rank : 89)
Query Neighborhood Hits	371	Target Neighborhood Hits	1075	Shared Neighborhood Hits	273
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

RIPK4_HUMAN
NC score	0.398260 (rank : 247)	θ value	9.92553e-07 (rank : 88)
Query Neighborhood Hits	371	Target Neighborhood Hits	1094	Shared Neighborhood Hits	275
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

ASPP1_HUMAN
NC score	0.395632 (rank : 248)	θ value	0.47712 (rank : 283)
Query Neighborhood Hits	371	Target Neighborhood Hits	956	Shared Neighborhood Hits	260
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

IASPP_HUMAN
NC score	0.394741 (rank : 249)	θ value	8.99809 (rank : 362)
Query Neighborhood Hits	371	Target Neighborhood Hits	688	Shared Neighborhood Hits	248
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

GIT2_HUMAN
NC score	0.394338 (rank : 250)	θ value	0.00175202 (rank : 207)
Query Neighborhood Hits	371	Target Neighborhood Hits	381	Shared Neighborhood Hits	243
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

ILK2_HUMAN
NC score	0.393064 (rank : 251)	θ value	8.40245e-06 (rank : 112)
Query Neighborhood Hits	371	Target Neighborhood Hits	848	Shared Neighborhood Hits	267
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

DDFL1_MOUSE
NC score	0.393042 (rank : 252)	θ value	0.00869519 (rank : 230)
Query Neighborhood Hits	371	Target Neighborhood Hits	324	Shared Neighborhood Hits	240
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

ANKK1_MOUSE
NC score	0.390969 (rank : 253)	θ value	5.44631e-05 (rank : 144)
Query Neighborhood Hits	371	Target Neighborhood Hits	1072	Shared Neighborhood Hits	274
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

NUD12_HUMAN
NC score	0.389370 (rank : 254)	θ value	3.0926 (rank : 327)
Query Neighborhood Hits	371	Target Neighborhood Hits	222	Shared Neighborhood Hits	193
SwissProt Accessions	Q9BQG2, Q8TAL7	Gene names	NUDT12
Domain Architecture	No domain graphic available
Description	Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12).

GLSL_HUMAN
NC score	0.387979 (rank : 255)	θ value	0.0563607 (rank : 253)
Query Neighborhood Hits	371	Target Neighborhood Hits	211	Shared Neighborhood Hits	194
SwissProt Accessions	Q9UI32, Q9NYY2, Q9UI31	Gene names	GLS2, GA
Domain Architecture
Description	Glutaminase liver isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (L-glutaminase).

ASPP1_MOUSE
NC score	0.387873 (rank : 256)	θ value	0.47712 (rank : 284)
Query Neighborhood Hits	371	Target Neighborhood Hits	1244	Shared Neighborhood Hits	265
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ANR45_HUMAN
NC score	0.385151 (rank : 257)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	371	Target Neighborhood Hits	201	Shared Neighborhood Hits	180
SwissProt Accessions	Q5TZF3, Q6ZST1	Gene names	ANKRD45
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 45.

GLSL_MOUSE
NC score	0.382306 (rank : 258)	θ value	0.0330416 (rank : 249)
Query Neighborhood Hits	371	Target Neighborhood Hits	212	Shared Neighborhood Hits	194
SwissProt Accessions	Q571F8	Gene names	Gls2, Kiaa4146
Domain Architecture	No domain graphic available
Description	Glutaminase liver isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (L-glutaminase).

ILK1_HUMAN
NC score	0.379816 (rank : 259)	θ value	8.40245e-06 (rank : 111)
Query Neighborhood Hits	371	Target Neighborhood Hits	857	Shared Neighborhood Hits	267
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK_MOUSE
NC score	0.379379 (rank : 260)	θ value	4.92598e-06 (rank : 105)
Query Neighborhood Hits	371	Target Neighborhood Hits	858	Shared Neighborhood Hits	268
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

TRPV6_MOUSE
NC score	0.376735 (rank : 261)	θ value	0.0563607 (rank : 254)
Query Neighborhood Hits	371	Target Neighborhood Hits	284	Shared Neighborhood Hits	241
SwissProt Accessions	Q91WD2	Gene names	Trpv6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1).

AN13B_MOUSE
NC score	0.374907 (rank : 262)	θ value	5.27518 (rank : 338)
Query Neighborhood Hits	371	Target Neighborhood Hits	276	Shared Neighborhood Hits	245
SwissProt Accessions	Q5F259, Q6IR40	Gene names	Ankrd13b
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13B.

AN13B_HUMAN
NC score	0.374070 (rank : 263)	θ value	5.27518 (rank : 337)
Query Neighborhood Hits	371	Target Neighborhood Hits	265	Shared Neighborhood Hits	245
SwissProt Accessions	Q86YJ7, Q8N7S9	Gene names	ANKRD13B
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13B.

ANKY1_HUMAN
NC score	0.373078 (rank : 264)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	371	Target Neighborhood Hits	248	Shared Neighborhood Hits	198
SwissProt Accessions	Q9P2S6, Q8IYX5, Q8NDK5, Q9NX10	Gene names	ANKMY1, TSAL1, ZMYND13
Domain Architecture
Description	Ankyrin repeat and MYND domain-containing protein 1 (Testis-specific ankyrin-like protein 1) (Zinc-finger MYND domain-containing protein 13).

ASB14_HUMAN
NC score	0.372949 (rank : 265)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	371	Target Neighborhood Hits	187	Shared Neighborhood Hits	170
SwissProt Accessions	Q8WXK2	Gene names	ASB14
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 14 (ASB-14).

GLSK_HUMAN
NC score	0.365646 (rank : 266)	θ value	0.0563607 (rank : 252)
Query Neighborhood Hits	371	Target Neighborhood Hits	204	Shared Neighborhood Hits	182
SwissProt Accessions	O94925, Q9UL05, Q9UL06, Q9UL07, Q9UN40	Gene names	GLS, GLS1, KIAA0838
Domain Architecture
Description	Glutaminase kidney isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (K-glutaminase).

UACA_HUMAN
NC score	0.364309 (rank : 267)	θ value	0.000158464 (rank : 167)
Query Neighborhood Hits	371	Target Neighborhood Hits	1622	Shared Neighborhood Hits	277
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

NOTC4_MOUSE
NC score	0.362351 (rank : 268)	θ value	4.0297e-08 (rank : 58)
Query Neighborhood Hits	371	Target Neighborhood Hits	872	Shared Neighborhood Hits	272
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

NOTC4_HUMAN
NC score	0.358402 (rank : 269)	θ value	5.26297e-08 (rank : 61)
Query Neighborhood Hits	371	Target Neighborhood Hits	905	Shared Neighborhood Hits	273
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

IASPP_MOUSE
NC score	0.352336 (rank : 270)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	371	Target Neighborhood Hits	1024	Shared Neighborhood Hits	249
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

AN13C_HUMAN
NC score	0.351372 (rank : 271)	θ value	5.27518 (rank : 339)
Query Neighborhood Hits	371	Target Neighborhood Hits	241	Shared Neighborhood Hits	230
SwissProt Accessions	Q8N6S4, Q5VYH4, Q5VYH5, Q6PJE4, Q9H0N9	Gene names	ANKRD13C
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13C.

AN13C_MOUSE
NC score	0.343835 (rank : 272)	θ value	5.27518 (rank : 340)
Query Neighborhood Hits	371	Target Neighborhood Hits	242	Shared Neighborhood Hits	226
SwissProt Accessions	Q3UX43, Q6P1G4	Gene names	Ankrd13c
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13C.

UACA_MOUSE
NC score	0.343611 (rank : 273)	θ value	0.00134147 (rank : 201)
Query Neighborhood Hits	371	Target Neighborhood Hits	1620	Shared Neighborhood Hits	281
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

TRPV5_MOUSE
NC score	0.342449 (rank : 274)	θ value	0.0736092 (rank : 260)
Query Neighborhood Hits	371	Target Neighborhood Hits	278	Shared Neighborhood Hits	235
SwissProt Accessions	P69744	Gene names	Trpv5
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC1) (Calcium transport protein 2) (CaT2).

DDEF2_HUMAN
NC score	0.339571 (rank : 275)	θ value	0.00175202 (rank : 204)
Query Neighborhood Hits	371	Target Neighborhood Hits	599	Shared Neighborhood Hits	229
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
NC score	0.337886 (rank : 276)	θ value	0.00175202 (rank : 205)
Query Neighborhood Hits	371	Target Neighborhood Hits	625	Shared Neighborhood Hits	232
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

NOTC3_MOUSE
NC score	0.334975 (rank : 277)	θ value	3.64472e-09 (rank : 40)
Query Neighborhood Hits	371	Target Neighborhood Hits	975	Shared Neighborhood Hits	274
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

NOTC3_HUMAN
NC score	0.333146 (rank : 278)	θ value	2.79066e-09 (rank : 39)
Query Neighborhood Hits	371	Target Neighborhood Hits	1062	Shared Neighborhood Hits	274
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

DDFL1_HUMAN
NC score	0.332781 (rank : 279)	θ value	0.000270298 (rank : 176)
Query Neighborhood Hits	371	Target Neighborhood Hits	353	Shared Neighborhood Hits	224
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

NOTC1_HUMAN
NC score	0.330967 (rank : 280)	θ value	1.63604e-09 (rank : 37)
Query Neighborhood Hits	371	Target Neighborhood Hits	906	Shared Neighborhood Hits	271
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

NOTC2_HUMAN
NC score	0.330483 (rank : 281)	θ value	4.76016e-09 (rank : 41)
Query Neighborhood Hits	371	Target Neighborhood Hits	1113	Shared Neighborhood Hits	269
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

ANR26_MOUSE
NC score	0.330307 (rank : 282)	θ value	0.000461057 (rank : 184)
Query Neighborhood Hits	371	Target Neighborhood Hits	1554	Shared Neighborhood Hits	272
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

NOTC2_MOUSE
NC score	0.329429 (rank : 283)	θ value	4.76016e-09 (rank : 42)
Query Neighborhood Hits	371	Target Neighborhood Hits	1069	Shared Neighborhood Hits	272
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

AN13A_HUMAN
NC score	0.324724 (rank : 284)	θ value	0.163984 (rank : 270)
Query Neighborhood Hits	371	Target Neighborhood Hits	243	Shared Neighborhood Hits	213
SwissProt Accessions	Q8IZ07, O60736	Gene names	ANKRD13A, ANKRD13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13A (Protein KE03).

CT012_MOUSE
NC score	0.320157 (rank : 285)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	371	Target Neighborhood Hits	229	Shared Neighborhood Hits	172
SwissProt Accessions	Q8C008, Q8C060	Gene names
Domain Architecture	No domain graphic available
Description	Protein C20orf12 homolog.

TNI3K_HUMAN
NC score	0.319773 (rank : 286)	θ value	4.92598e-06 (rank : 106)
Query Neighborhood Hits	371	Target Neighborhood Hits	1084	Shared Neighborhood Hits	274
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNI3K_MOUSE
NC score	0.317310 (rank : 287)	θ value	2.88788e-06 (rank : 95)
Query Neighborhood Hits	371	Target Neighborhood Hits	1079	Shared Neighborhood Hits	275
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

DGKZ_HUMAN
NC score	0.310468 (rank : 288)	θ value	0.00175202 (rank : 206)
Query Neighborhood Hits	371	Target Neighborhood Hits	551	Shared Neighborhood Hits	215
SwissProt Accessions	Q13574, O00542	Gene names	DGKZ, DAGK6
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

ANR26_HUMAN
NC score	0.308844 (rank : 289)	θ value	0.0113563 (rank : 232)
Query Neighborhood Hits	371	Target Neighborhood Hits	1614	Shared Neighborhood Hits	275
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

TRPV5_HUMAN
NC score	0.308358 (rank : 290)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	371	Target Neighborhood Hits	261	Shared Neighborhood Hits	214
SwissProt Accessions	Q9NQA5, Q8NDW5, Q8NDX7, Q8NDX8, Q96PM6	Gene names	TRPV5, ECAC1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Calcium transport protein 2) (CaT2).

AN13A_MOUSE
NC score	0.307825 (rank : 291)	θ value	0.0961366 (rank : 262)
Query Neighborhood Hits	371	Target Neighborhood Hits	226	Shared Neighborhood Hits	209
SwissProt Accessions	Q80UP5, Q2VPQ7, Q6P7F2	Gene names	Ankrd13a, Ankrd13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13A.

TRPV6_HUMAN
NC score	0.302164 (rank : 292)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	371	Target Neighborhood Hits	262	Shared Neighborhood Hits	214
SwissProt Accessions	Q9H1D0, Q8TDL3, Q8WXR8, Q96LC5, Q9H1D1, Q9H296	Gene names	TRPV6, ECAC2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1) (CaT-like) (CaT-L).

TEX14_HUMAN
NC score	0.299707 (rank : 293)	θ value	0.00298849 (rank : 218)
Query Neighborhood Hits	371	Target Neighborhood Hits	1103	Shared Neighborhood Hits	238
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
NC score	0.297022 (rank : 294)	θ value	0.0736092 (rank : 259)
Query Neighborhood Hits	371	Target Neighborhood Hits	1333	Shared Neighborhood Hits	252
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

DGKI_HUMAN
NC score	0.294650 (rank : 295)	θ value	5.44631e-05 (rank : 148)
Query Neighborhood Hits	371	Target Neighborhood Hits	609	Shared Neighborhood Hits	210
SwissProt Accessions	O75912, Q9NZ49	Gene names	DGKI
Domain Architecture
Description	Diacylglycerol kinase iota (EC 2.7.1.107) (Diglyceride kinase iota) (DGK-iota) (DAG kinase iota).

CT012_HUMAN
NC score	0.290888 (rank : 296)	θ value	4.03905 (rank : 334)
Query Neighborhood Hits	371	Target Neighborhood Hits	205	Shared Neighborhood Hits	166
SwissProt Accessions	Q9NVP4, Q4F7X1, Q5QPD9, Q5QPE0, Q68DN8, Q6ZMX9, Q96NF0, Q9H1E0, Q9H442	Gene names	C20orf12
Domain Architecture
Description	Protein C20orf12.

DAPK1_MOUSE
NC score	0.288116 (rank : 297)	θ value	1.38499e-08 (rank : 48)
Query Neighborhood Hits	371	Target Neighborhood Hits	1138	Shared Neighborhood Hits	275
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

NOTC1_MOUSE
NC score	0.287594 (rank : 298)	θ value	1.80886e-08 (rank : 52)
Query Neighborhood Hits	371	Target Neighborhood Hits	916	Shared Neighborhood Hits	255
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

DGKZ_MOUSE
NC score	0.287468 (rank : 299)	θ value	0.00390308 (rank : 220)
Query Neighborhood Hits	371	Target Neighborhood Hits	542	Shared Neighborhood Hits	196
SwissProt Accessions	Q80UP3	Gene names	Dgkz
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

CENG1_MOUSE
NC score	0.280432 (rank : 300)	θ value	0.62314 (rank : 289)
Query Neighborhood Hits	371	Target Neighborhood Hits	531	Shared Neighborhood Hits	231
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

CENG1_HUMAN
NC score	0.280401 (rank : 301)	θ value	0.62314 (rank : 288)
Query Neighborhood Hits	371	Target Neighborhood Hits	544	Shared Neighborhood Hits	233
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

ANKR9_MOUSE
NC score	0.279971 (rank : 302)	θ value	0.00035302 (rank : 177)
Query Neighborhood Hits	371	Target Neighborhood Hits	120	Shared Neighborhood Hits	115
SwissProt Accessions	Q8BH83, Q3TA09, Q8BHR3	Gene names	Ankrd9
Domain Architecture
Description	Ankyrin repeat domain-containing protein 9.

DAPK1_HUMAN
NC score	0.279181 (rank : 303)	θ value	3.41135e-07 (rank : 77)
Query Neighborhood Hits	371	Target Neighborhood Hits	1130	Shared Neighborhood Hits	273
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

CENG2_HUMAN
NC score	0.278712 (rank : 304)	θ value	0.62314 (rank : 290)
Query Neighborhood Hits	371	Target Neighborhood Hits	471	Shared Neighborhood Hits	244
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

CENG2_MOUSE
NC score	0.277410 (rank : 305)	θ value	1.06291 (rank : 298)
Query Neighborhood Hits	371	Target Neighborhood Hits	463	Shared Neighborhood Hits	242
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

DDEF1_MOUSE
NC score	0.270640 (rank : 306)	θ value	3.19293e-05 (rank : 135)
Query Neighborhood Hits	371	Target Neighborhood Hits	592	Shared Neighborhood Hits	192
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

CENG3_HUMAN
NC score	0.254322 (rank : 307)	θ value	3.0926 (rank : 325)
Query Neighborhood Hits	371	Target Neighborhood Hits	455	Shared Neighborhood Hits	225
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_MOUSE
NC score	0.254320 (rank : 308)	θ value	3.0926 (rank : 326)
Query Neighborhood Hits	371	Target Neighborhood Hits	467	Shared Neighborhood Hits	225
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

ANKR9_HUMAN
NC score	0.244642 (rank : 309)	θ value	0.00228821 (rank : 210)
Query Neighborhood Hits	371	Target Neighborhood Hits	99	Shared Neighborhood Hits	96
SwissProt Accessions	Q96BM1	Gene names	ANKRD9
Domain Architecture
Description	Ankyrin repeat domain-containing protein 9.

CLR59_HUMAN
NC score	0.239488 (rank : 310)	θ value	0.0252991 (rank : 243)
Query Neighborhood Hits	371	Target Neighborhood Hits	163	Shared Neighborhood Hits	140
SwissProt Accessions	Q96DZ5, Q8WWL1, Q96C99, Q9UFT7	Gene names	CLIPR59
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 170-related 59 kDa protein (CLIPR-59) (CLIP-170-related 59 kDa protein).

ANKZ1_MOUSE
NC score	0.236514 (rank : 311)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	371	Target Neighborhood Hits	208	Shared Neighborhood Hits	147
SwissProt Accessions	Q80UU1, Q9CZF5	Gene names	Ankzf1, D1Ertd161e
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1.

ANKZ1_HUMAN
NC score	0.223680 (rank : 312)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	371	Target Neighborhood Hits	236	Shared Neighborhood Hits	152
SwissProt Accessions	Q9H8Y5, Q9NVZ4	Gene names	ANKZF1, ZNF744
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1 (Zinc finger protein 744).

IKBL_HUMAN
NC score	0.216790 (rank : 313)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	371	Target Neighborhood Hits	168	Shared Neighborhood Hits	137
SwissProt Accessions	Q9UBC1, Q14625, Q9UBX4	Gene names	NFKBIL1, IKBL
Domain Architecture
Description	NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like) (I- kappa-B-like) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1).

ABTB1_MOUSE
NC score	0.212002 (rank : 314)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	371	Target Neighborhood Hits	349	Shared Neighborhood Hits	174
SwissProt Accessions	Q99LJ2, Q8C2K7, Q91XU4	Gene names	Abtb1, Bpoz
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 1.

IKBL_MOUSE
NC score	0.211679 (rank : 315)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	371	Target Neighborhood Hits	196	Shared Neighborhood Hits	138
SwissProt Accessions	O88995, Q91X16, Q9R1Y3	Gene names	Nfkbil1, Ikbl
Domain Architecture
Description	NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like) (I- kappa-B-like) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1).

YAP1_MOUSE
NC score	0.191257 (rank : 316)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	371	Target Neighborhood Hits	96	Shared Neighborhood Hits	16
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

BAT4_MOUSE
NC score	0.189858 (rank : 317)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	371	Target Neighborhood Hits	171	Shared Neighborhood Hits	115
SwissProt Accessions	Q61858, Q9R065	Gene names	Bat4, Bat-4, G5
Domain Architecture
Description	Protein BAT4 (HLA-B-associated transcript 4) (G5 protein).

ABTB1_HUMAN
NC score	0.183365 (rank : 318)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	371	Target Neighborhood Hits	325	Shared Neighborhood Hits	158
SwissProt Accessions	Q969K4, Q6ZNU9, Q71MF1, Q96S62, Q96S63	Gene names	ABTB1, BPOZ
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 1 (Elongation factor 1A-binding protein).

RSNL2_HUMAN
NC score	0.180158 (rank : 319)	θ value	2.36792 (rank : 318)
Query Neighborhood Hits	371	Target Neighborhood Hits	136	Shared Neighborhood Hits	113
SwissProt Accessions	Q8N3C7, Q7Z4U3, Q96BR7, Q96MA5, Q9H7C0	Gene names	RSNL2
Domain Architecture	No domain graphic available
Description	Restin-like protein 2.

SAV1_MOUSE
NC score	0.173769 (rank : 320)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	371	Target Neighborhood Hits	48	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

SAV1_HUMAN
NC score	0.173550 (rank : 321)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	371	Target Neighborhood Hits	51	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

BAT4_HUMAN
NC score	0.170082 (rank : 322)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	371	Target Neighborhood Hits	157	Shared Neighborhood Hits	105
SwissProt Accessions	O95872	Gene names	BAT4, G5
Domain Architecture
Description	Protein BAT4 (HLA-B-associated transcript 4) (G5 protein).

PINL_HUMAN
NC score	0.164149 (rank : 323)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	371	Target Neighborhood Hits	47	Shared Neighborhood Hits	13
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

RSNL2_MOUSE
NC score	0.161758 (rank : 324)	θ value	1.81305 (rank : 306)
Query Neighborhood Hits	371	Target Neighborhood Hits	129	Shared Neighborhood Hits	96
SwissProt Accessions	Q8CI96, Q8BW09, Q921Q4, Q9D2S6	Gene names	Rsnl2
Domain Architecture	No domain graphic available
Description	Restin-like protein 2.

WWC1_HUMAN
NC score	0.150983 (rank : 325)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	371	Target Neighborhood Hits	290	Shared Neighborhood Hits	28
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
NC score	0.150082 (rank : 326)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	371	Target Neighborhood Hits	290	Shared Neighborhood Hits	25
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

TRPV1_MOUSE
NC score	0.147428 (rank : 327)	θ value	5.27518 (rank : 346)
Query Neighborhood Hits	371	Target Neighborhood Hits	189	Shared Neighborhood Hits	145
SwissProt Accessions	Q704Y3, Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0	Gene names	Trpv1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).

TRPV3_MOUSE
NC score	0.147255 (rank : 328)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	371	Target Neighborhood Hits	188	Shared Neighborhood Hits	121
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

TRPV3_HUMAN
NC score	0.145161 (rank : 329)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	371	Target Neighborhood Hits	198	Shared Neighborhood Hits	131
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

TRPV1_HUMAN
NC score	0.136566 (rank : 330)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	371	Target Neighborhood Hits	184	Shared Neighborhood Hits	137
SwissProt Accessions	Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22	Gene names	TRPV1, VR1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Capsaicin receptor).

PIN1_HUMAN
NC score	0.136388 (rank : 331)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	371	Target Neighborhood Hits	59	Shared Neighborhood Hits	13
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PIN1_MOUSE
NC score	0.135312 (rank : 332)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	371	Target Neighborhood Hits	60	Shared Neighborhood Hits	13
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

WWOX_HUMAN
NC score	0.132475 (rank : 333)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	371	Target Neighborhood Hits	115	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

WWOX_MOUSE
NC score	0.131213 (rank : 334)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	371	Target Neighborhood Hits	118	Shared Neighborhood Hits	13
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

BAG3_HUMAN
NC score	0.129178 (rank : 335)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	371	Target Neighborhood Hits	314	Shared Neighborhood Hits	23
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

CMTA1_HUMAN
NC score	0.127804 (rank : 336)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	371	Target Neighborhood Hits	217	Shared Neighborhood Hits	99
SwissProt Accessions	Q9Y6Y1, Q5VUE1	Gene names	CAMTA1, KIAA0833
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 1.

TRPV2_HUMAN
NC score	0.122977 (rank : 337)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	371	Target Neighborhood Hits	130	Shared Neighborhood Hits	103
SwissProt Accessions	Q9Y5S1, Q9Y670	Gene names	TRPV2, VRL
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1).

WWTR1_MOUSE
NC score	0.115877 (rank : 338)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	371	Target Neighborhood Hits	54	Shared Neighborhood Hits	13
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

WWTR1_HUMAN
NC score	0.114770 (rank : 339)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	371	Target Neighborhood Hits	76	Shared Neighborhood Hits	14
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

YAP1_HUMAN
NC score	0.111461 (rank : 340)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	371	Target Neighborhood Hits	173	Shared Neighborhood Hits	19
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

BAG3_MOUSE
NC score	0.111414 (rank : 341)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	371	Target Neighborhood Hits	513	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

PKHA5_HUMAN
NC score	0.109767 (rank : 342)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	371	Target Neighborhood Hits	455	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

CMTA2_HUMAN
NC score	0.102675 (rank : 343)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	371	Target Neighborhood Hits	199	Shared Neighborhood Hits	86
SwissProt Accessions	O94983, Q7Z6M8, Q8N3V0, Q8NDG4, Q96G17	Gene names	CAMTA2, KIAA0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

CMTA2_MOUSE
NC score	0.092950 (rank : 344)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	371	Target Neighborhood Hits	216	Shared Neighborhood Hits	75
SwissProt Accessions	Q80Y50, Q3TFK0, Q5SX68, Q80TP1, Q8R0D9, Q8R2N5	Gene names	Camta2, Kiaa0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

MAGI2_MOUSE
NC score	0.092629 (rank : 345)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	371	Target Neighborhood Hits	370	Shared Neighborhood Hits	15
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

TRPV2_MOUSE
NC score	0.089189 (rank : 346)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	371	Target Neighborhood Hits	111	Shared Neighborhood Hits	83
SwissProt Accessions	Q9WTR1, Q99K71	Gene names	Trpv2, Grc
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Growth factor-regulated calcium channel) (GRC).

MAGI1_MOUSE
NC score	0.089128 (rank : 347)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	371	Target Neighborhood Hits	403	Shared Neighborhood Hits	19
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

PRP40_MOUSE
NC score	0.087254 (rank : 348)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	371	Target Neighborhood Hits	447	Shared Neighborhood Hits	31
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

MAGI1_HUMAN
NC score	0.086796 (rank : 349)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	371	Target Neighborhood Hits	388	Shared Neighborhood Hits	17
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

GAS7_MOUSE
NC score	0.086248 (rank : 350)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	371	Target Neighborhood Hits	259	Shared Neighborhood Hits	20
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

MAGI2_HUMAN
NC score	0.086013 (rank : 351)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	371	Target Neighborhood Hits	373	Shared Neighborhood Hits	17
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

GAS7_HUMAN
NC score	0.085754 (rank : 352)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	371	Target Neighborhood Hits	258	Shared Neighborhood Hits	18
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

ANKF1_HUMAN
NC score	0.085639 (rank : 353)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	371	Target Neighborhood Hits	126	Shared Neighborhood Hits	67
SwissProt Accessions	Q8N957	Gene names	ANKFN1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and fibronectin type-III domain-containing protein 1.

PRP40_HUMAN
NC score	0.084877 (rank : 354)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	371	Target Neighborhood Hits	442	Shared Neighborhood Hits	27
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

GNPTA_HUMAN
NC score	0.075588 (rank : 355)	θ value	0.125558 (rank : 268)
Query Neighborhood Hits	371	Target Neighborhood Hits	43	Shared Neighborhood Hits	10
SwissProt Accessions	Q3T906, Q3ZQK2, Q6IPW5, Q86TQ2, Q96N13, Q9ULL2	Gene names	GNPTAB, GNPTA, KIAA1208
Domain Architecture	No domain graphic available
Description	N-acetylglucosamine-1-phosphotransferase subunits alpha/beta precursor (EC 2.7.8.17) (GlcNAc-1-phosphotransferase alpha/beta subunits) (UDP- N-acetylglucosamine-1-phosphotransferase alpha/beta subunits) (Stealth protein GNPTAB) [Contains: N-acetylglucosamine-1-phosphotransferase subunit alpha; N-acetylglucosamine-1-phosphotransferase subunit beta].

SRGEF_HUMAN
NC score	0.073536 (rank : 356)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	371	Target Neighborhood Hits	33	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UGK8, Q9UGK9	Gene names	SERGEF, DELGEF, GNEFR
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

RPGR_HUMAN
NC score	0.072009 (rank : 357)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	371	Target Neighborhood Hits	279	Shared Neighborhood Hits	15
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

SRGEF_MOUSE
NC score	0.071440 (rank : 358)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	371	Target Neighborhood Hits	37	Shared Neighborhood Hits	8
SwissProt Accessions	Q80YD6, Q9QXB7	Gene names	Sergef, Delgef, Gnefr
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

RCC2_HUMAN
NC score	0.071104 (rank : 359)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	371	Target Neighborhood Hits	36	Shared Neighborhood Hits	8
SwissProt Accessions	Q9P258, Q8IVL9, Q9BSN6, Q9NPV8	Gene names	RCC2, KIAA1470, TD60
Domain Architecture	No domain graphic available
Description	Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like protein TD- 60).

TRPC6_HUMAN
NC score	0.070470 (rank : 360)	θ value	6.88961 (rank : 358)
Query Neighborhood Hits	371	Target Neighborhood Hits	171	Shared Neighborhood Hits	94
SwissProt Accessions	Q9Y210, Q9HCW3, Q9NQA8, Q9NQA9	Gene names	TRPC6, TRP6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6).

RCC2_MOUSE
NC score	0.070413 (rank : 361)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	371	Target Neighborhood Hits	37	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BK67, Q6ZPQ0	Gene names	Rcc2, Kiaa1470
Domain Architecture	No domain graphic available
Description	Protein RCC2.

SMAP1_MOUSE
NC score	0.070061 (rank : 362)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	371	Target Neighborhood Hits	120	Shared Neighborhood Hits	20
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

CENA1_HUMAN
NC score	0.069366 (rank : 363)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	371	Target Neighborhood Hits	87	Shared Neighborhood Hits	19
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

SMP1L_HUMAN
NC score	0.069013 (rank : 364)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	371	Target Neighborhood Hits	74	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

TRPV4_HUMAN
NC score	0.069004 (rank : 365)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	371	Target Neighborhood Hits	150	Shared Neighborhood Hits	71
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

SMP1L_MOUSE
NC score	0.068884 (rank : 366)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	371	Target Neighborhood Hits	70	Shared Neighborhood Hits	19
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

RCBT2_MOUSE
NC score	0.068598 (rank : 367)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	371	Target Neighborhood Hits	156	Shared Neighborhood Hits	13
SwissProt Accessions	Q99LJ7, Q3TUA3, Q8BMG2	Gene names	Rcbtb2, Chc1l
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like).

RCC1_HUMAN
NC score	0.068098 (rank : 368)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	371	Target Neighborhood Hits	47	Shared Neighborhood Hits	6
SwissProt Accessions	P18754	Gene names	RCC1, CHC1
Domain Architecture
Description	Regulator of chromosome condensation (Chromosome condensation protein 1) (Cell cycle regulatory protein).

RCBT2_HUMAN
NC score	0.067970 (rank : 369)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	371	Target Neighborhood Hits	158	Shared Neighborhood Hits	13
SwissProt Accessions	O95199	Gene names	RCBTB2, CHC1L, RLG
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like) (CHC1-L) (RCC1-like G exchanging factor).

SMAP1_HUMAN
NC score	0.067863 (rank : 370)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	371	Target Neighborhood Hits	98	Shared Neighborhood Hits	18
SwissProt Accessions	Q8IYB5, Q53H70, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4	Gene names	SMAP1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

FKBP3_HUMAN
NC score	0.067762 (rank : 371)	θ value	0.00020696 (rank : 171)
Query Neighborhood Hits	371	Target Neighborhood Hits	35	Shared Neighborhood Hits	4
SwissProt Accessions	Q00688, Q14317	Gene names	FKBP3, FKBP25
Domain Architecture
Description	FK506-binding protein 3 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) (25 kDa FKBP) (FKBP-25) (Rapamycin- selective 25 kDa immunophilin).

RPGR_MOUSE
NC score	0.067527 (rank : 372)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	371	Target Neighborhood Hits	281	Shared Neighborhood Hits	17
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

ARFG1_MOUSE
NC score	0.067010 (rank : 373)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	371	Target Neighborhood Hits	51	Shared Neighborhood Hits	19
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

ARFG3_MOUSE
NC score	0.066227 (rank : 374)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	371	Target Neighborhood Hits	80	Shared Neighborhood Hits	19
SwissProt Accessions	Q9D8S3, Q99KN8	Gene names	Arfgap3
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

RCC1_MOUSE
NC score	0.066081 (rank : 375)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	371	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VE37, Q3UDB6	Gene names	Rcc1, Chc1
Domain Architecture	No domain graphic available
Description	Regulator of chromosome condensation (Chromosome condensation protein 1).

K1333_MOUSE
NC score	0.066018 (rank : 376)	θ value	0.62314 (rank : 292)
Query Neighborhood Hits	371	Target Neighborhood Hits	53	Shared Neighborhood Hits	13
SwissProt Accessions	Q5RJY2, Q6ZPT7, Q8BNA4	Gene names	Kiaa1333
Domain Architecture	No domain graphic available
Description	Protein KIAA1333 (EC 6.3.2.-).

ARFG3_HUMAN
NC score	0.065640 (rank : 377)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	371	Target Neighborhood Hits	56	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ARFG1_HUMAN
NC score	0.064975 (rank : 378)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	371	Target Neighborhood Hits	60	Shared Neighborhood Hits	18
SwissProt Accessions	Q8N6T3, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0	Gene names	ARFGAP1, ARF1GAP
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

WBS16_MOUSE
NC score	0.064864 (rank : 379)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	371	Target Neighborhood Hits	31	Shared Neighborhood Hits	6
SwissProt Accessions	Q9CYF5	Gene names	Wbscr16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein homolog.

FKBP3_MOUSE
NC score	0.064620 (rank : 380)	θ value	0.000602161 (rank : 190)
Query Neighborhood Hits	371	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	Q62446, Q9WTJ7	Gene names	Fkbp3, Fkbp25
Domain Architecture
Description	FK506-binding protein 3 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) (25 kDa FKBP) (FKBP-25) (Rapamycin- selective 25 kDa immunophilin).

RCBT1_MOUSE
NC score	0.063938 (rank : 381)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	371	Target Neighborhood Hits	157	Shared Neighborhood Hits	11
SwissProt Accessions	Q6NXM2, Q8BTZ6, Q8BZV0	Gene names	Rcbtb1
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1).

WBS16_HUMAN
NC score	0.063719 (rank : 382)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	371	Target Neighborhood Hits	29	Shared Neighborhood Hits	6
SwissProt Accessions	Q96I51, Q548B1, Q9H0G7	Gene names	WBSCR16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein (RCC1-like G exchanging factor-like protein).

SETD2_HUMAN
NC score	0.063581 (rank : 383)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	371	Target Neighborhood Hits	412	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

CENA2_MOUSE
NC score	0.063478 (rank : 384)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	371	Target Neighborhood Hits	68	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

CENA2_HUMAN
NC score	0.062797 (rank : 385)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	371	Target Neighborhood Hits	83	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

RCBT1_HUMAN
NC score	0.062443 (rank : 386)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	371	Target Neighborhood Hits	158	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NDN9, Q969U9	Gene names	RCBTB1, CLLD7, E4.5
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1) (Chronic lymphocytic leukemia deletion region gene 7 protein) (CLL deletion region gene 7 protein).

TRPV4_MOUSE
NC score	0.060936 (rank : 387)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	371	Target Neighborhood Hits	117	Shared Neighborhood Hits	68
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

GNPTA_MOUSE
NC score	0.058561 (rank : 388)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	371	Target Neighborhood Hits	47	Shared Neighborhood Hits	9
SwissProt Accessions	Q69ZN6, Q3U3K6, Q3US34	Gene names	Gnptab, Gnpta, Kiaa1208
Domain Architecture	No domain graphic available
Description	N-acetylglucosamine-1-phosphotransferase subunits alpha/beta precursor (EC 2.7.8.17) (GlcNAc-1-phosphotransferase alpha/beta subunits) (UDP- N-acetylglucosamine-1-phosphotransferase alpha/beta subunits) (Stealth protein GNPTAB) [Contains: N-acetylglucosamine-1-phosphotransferase subunit alpha; N-acetylglucosamine-1-phosphotransferase subunit beta].

STXB4_HUMAN
NC score	0.058247 (rank : 389)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	371	Target Neighborhood Hits	616	Shared Neighborhood Hits	31
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_MOUSE
NC score	0.057443 (rank : 390)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	371	Target Neighborhood Hits	629	Shared Neighborhood Hits	34
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

CEND1_HUMAN
NC score	0.057309 (rank : 391)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	371	Target Neighborhood Hits	284	Shared Neighborhood Hits	30
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

ALS2_HUMAN
NC score	0.057122 (rank : 392)	θ value	0.62314 (rank : 287)
Query Neighborhood Hits	371	Target Neighborhood Hits	121	Shared Neighborhood Hits	8
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

JAG2_MOUSE
NC score	0.056955 (rank : 393)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	371	Target Neighborhood Hits	504	Shared Neighborhood Hits	13
SwissProt Accessions	Q9QYE5, O55139, O70219	Gene names	Jag2
Domain Architecture
Description	Jagged-2 precursor (Jagged2).

APBB2_HUMAN
NC score	0.056668 (rank : 394)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	371	Target Neighborhood Hits	96	Shared Neighborhood Hits	13
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

LCE1B_HUMAN
NC score	0.056490 (rank : 395)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	371	Target Neighborhood Hits	58	Shared Neighborhood Hits	7
SwissProt Accessions	Q5T7P3	Gene names	LCE1B, LEP2, SPRL2A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1B (Late envelope protein 2) (Small proline-rich-like epidermal differentiation complex protein 2A).

LRRK1_MOUSE
NC score	0.056163 (rank : 396)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	371	Target Neighborhood Hits	1267	Shared Neighborhood Hits	120
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

JAG2_HUMAN
NC score	0.055779 (rank : 397)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	371	Target Neighborhood Hits	491	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y219, Q9UE17, Q9UE99, Q9UNK8, Q9Y6P9, Q9Y6Q0	Gene names	JAG2
Domain Architecture
Description	Jagged-2 precursor (Jagged2) (HJ2).

JAG1_HUMAN
NC score	0.055766 (rank : 398)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	371	Target Neighborhood Hits	514	Shared Neighborhood Hits	11
SwissProt Accessions	P78504, O14902, O15122, Q15816	Gene names	JAG1, JAGL1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (hJ1) (CD339 antigen).

DNER_MOUSE
NC score	0.055445 (rank : 399)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	371	Target Neighborhood Hits	413	Shared Neighborhood Hits	9
SwissProt Accessions	Q8JZM4, Q3U697, Q8R226, Q8R4T6, Q8VD97	Gene names	Dner, Bet, Bret
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor (Brain EGF repeat-containing transmembrane protein).

JAG1_MOUSE
NC score	0.055386 (rank : 400)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	371	Target Neighborhood Hits	518	Shared Neighborhood Hits	10
SwissProt Accessions	Q9QXX0	Gene names	Jag1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (CD339 antigen).

APBB2_MOUSE
NC score	0.055357 (rank : 401)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	371	Target Neighborhood Hits	88	Shared Neighborhood Hits	14
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

DNER_HUMAN
NC score	0.054645 (rank : 402)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	371	Target Neighborhood Hits	460	Shared Neighborhood Hits	10
SwissProt Accessions	Q8NFT8, Q53R88, Q53TP7, Q53TQ5, Q8IYT0, Q8TB42, Q9NTF1, Q9UDM2	Gene names	DNER, BET
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor.

CRUM2_HUMAN
NC score	0.054121 (rank : 403)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	371	Target Neighborhood Hits	453	Shared Neighborhood Hits	9
SwissProt Accessions	Q5IJ48, Q5JS41, Q5JS43, Q6ZTA9, Q6ZWI6	Gene names	CRB2
Domain Architecture	No domain graphic available
Description	Crumbs homolog 2 precursor (Crumbs-like protein 2).

CEND1_MOUSE
NC score	0.053688 (rank : 404)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	371	Target Neighborhood Hits	260	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CRUM1_HUMAN
NC score	0.053366 (rank : 405)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	371	Target Neighborhood Hits	457	Shared Neighborhood Hits	11
SwissProt Accessions	P82279, Q5K3A6, Q5TC28, Q5VUT1, Q6N027, Q8WWY0	Gene names	CRB1
Domain Architecture
Description	Crumbs homolog 1 precursor.

LCE1C_HUMAN
NC score	0.053224 (rank : 406)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	371	Target Neighborhood Hits	65	Shared Neighborhood Hits	7
SwissProt Accessions	Q5T751	Gene names	LCE1C, LEP3
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1C (Late envelope protein 3).

CRUM1_MOUSE
NC score	0.053145 (rank : 407)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	371	Target Neighborhood Hits	444	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VHS2, Q6ST50, Q71JF2, Q8BGR4	Gene names	Crb1
Domain Architecture	No domain graphic available
Description	Crumbs homolog 1 precursor.

LCE1D_HUMAN
NC score	0.052859 (rank : 408)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	371	Target Neighborhood Hits	44	Shared Neighborhood Hits	6
SwissProt Accessions	Q5T752	Gene names	LCE1D, LEP4
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1D (Late envelope protein 4).

EGFL9_HUMAN
NC score	0.052145 (rank : 409)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	371	Target Neighborhood Hits	365	Shared Neighborhood Hits	9
SwissProt Accessions	Q6UY11, Q9BQ54	Gene names	EGFL9
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 9 precursor (Multiple EGF-like domain protein 9).

EGFL9_MOUSE
NC score	0.051920 (rank : 410)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	371	Target Neighborhood Hits	379	Shared Neighborhood Hits	9
SwissProt Accessions	Q8K1E3, Q9QYP3	Gene names	Egfl9
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 9 precursor (Multiple EGF-like domain protein 9) (Endothelial cell-specific protein S-1).

CEND3_HUMAN
NC score	0.051834 (rank : 411)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	371	Target Neighborhood Hits	275	Shared Neighborhood Hits	24
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

TRPC3_HUMAN
NC score	0.051068 (rank : 412)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	371	Target Neighborhood Hits	137	Shared Neighborhood Hits	72
SwissProt Accessions	Q13507, O00593, Q15660	Gene names	TRPC3, TRP3
Domain Architecture
Description	Short transient receptor potential channel 3 (TrpC3) (Htrp-3) (Htrp3).

CEND3_MOUSE
NC score	0.051020 (rank : 413)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	371	Target Neighborhood Hits	228	Shared Neighborhood Hits	27
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

DLL3_MOUSE
NC score	0.050251 (rank : 414)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	371	Target Neighborhood Hits	399	Shared Neighborhood Hits	9
SwissProt Accessions	O88516, O35675, Q80W06, Q9QWL9, Q9QWZ7	Gene names	Dll3
Domain Architecture	No domain graphic available
Description	Delta-like protein 3 precursor (Drosophila Delta homolog 3) (M-Delta- 3).

CEND2_HUMAN
NC score	0.050004 (rank : 415)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	371	Target Neighborhood Hits	166	Shared Neighborhood Hits	22
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

K1333_HUMAN
NC score	0.045949 (rank : 416)	θ value	0.62314 (rank : 291)
Query Neighborhood Hits	371	Target Neighborhood Hits	50	Shared Neighborhood Hits	9
SwissProt Accessions	Q7L622, Q9BVR2, Q9H9E9, Q9NXC0, Q9P2L3	Gene names	KIAA1333
Domain Architecture	No domain graphic available
Description	Protein KIAA1333 (EC 6.3.2.-).

TRPC7_HUMAN
NC score	0.042708 (rank : 417)	θ value	8.99809 (rank : 371)
Query Neighborhood Hits	371	Target Neighborhood Hits	123	Shared Neighborhood Hits	63
SwissProt Accessions	Q9HCX4	Gene names	TRPC7, TRP7
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (TRP7 protein).

GRIN1_MOUSE
NC score	0.037507 (rank : 418)	θ value	0.0330416 (rank : 250)
Query Neighborhood Hits	371	Target Neighborhood Hits	337	Shared Neighborhood Hits	12
SwissProt Accessions	Q3UNH4, Q6PGF9, Q9QZY2	Gene names	Gprin1
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

GIDRP_MOUSE
NC score	0.034275 (rank : 419)	θ value	0.163984 (rank : 272)
Query Neighborhood Hits	371	Target Neighborhood Hits	96	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BJM3, Q3UGJ8, Q5U5U8	Gene names	Gidrp88, D19Ertd386e
Domain Architecture	No domain graphic available
Description	Growth inhibition and differentiation-related protein 88 homolog.

CSPG3_MOUSE
NC score	0.033211 (rank : 420)	θ value	4.03905 (rank : 333)
Query Neighborhood Hits	371	Target Neighborhood Hits	657	Shared Neighborhood Hits	14
SwissProt Accessions	P55066, Q6P1E3, Q8C4F8	Gene names	Cspg3, Ncan
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

SYNG_HUMAN
NC score	0.030219 (rank : 421)	θ value	0.0961366 (rank : 266)
Query Neighborhood Hits	371	Target Neighborhood Hits	160	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UMZ2, Q6ZT17	Gene names	AP1GBP1, SYNG
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

TPP2_MOUSE
NC score	0.027298 (rank : 422)	θ value	1.38821 (rank : 303)
Query Neighborhood Hits	371	Target Neighborhood Hits	24	Shared Neighborhood Hits	6
SwissProt Accessions	Q64514	Gene names	Tpp2
Domain Architecture
Description	Tripeptidyl-peptidase 2 (EC 3.4.14.10) (Tripeptidyl-peptidase II) (TPP-II) (Tripeptidyl aminopeptidase).

RAPSN_HUMAN
NC score	0.027090 (rank : 423)	θ value	0.813845 (rank : 297)
Query Neighborhood Hits	371	Target Neighborhood Hits	84	Shared Neighborhood Hits	5
SwissProt Accessions	Q13702, Q9BTD9	Gene names	RAPSN
Domain Architecture
Description	43 kDa receptor-associated protein of the synapse (RAPsyn) (Acetylcholine receptor-associated 43 kDa protein) (43 kDa postsynaptic protein).

TPP2_HUMAN
NC score	0.026790 (rank : 424)	θ value	1.38821 (rank : 302)
Query Neighborhood Hits	371	Target Neighborhood Hits	30	Shared Neighborhood Hits	6
SwissProt Accessions	P29144	Gene names	TPP2
Domain Architecture
Description	Tripeptidyl-peptidase 2 (EC 3.4.14.10) (Tripeptidyl-peptidase II) (TPP-II) (Tripeptidyl aminopeptidase).

FBX24_MOUSE
NC score	0.026731 (rank : 425)	θ value	6.88961 (rank : 350)
Query Neighborhood Hits	371	Target Neighborhood Hits	59	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D417	Gene names	Fbxo24, Fbx24
Domain Architecture	No domain graphic available
Description	F-box only protein 24.

SYYM_MOUSE
NC score	0.025961 (rank : 426)	θ value	0.62314 (rank : 293)
Query Neighborhood Hits	371	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BYL4, Q6PAH7	Gene names	Yars2
Domain Architecture	No domain graphic available
Description	Tyrosyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.1) (Tyrosine--tRNA ligase) (TyrRS).

RAPSN_MOUSE
NC score	0.024331 (rank : 427)	θ value	1.81305 (rank : 305)
Query Neighborhood Hits	371	Target Neighborhood Hits	92	Shared Neighborhood Hits	5
SwissProt Accessions	P12672	Gene names	Rapsn
Domain Architecture
Description	43 kDa receptor-associated protein of the synapse (RAPsyn) (Acetylcholine receptor-associated 43 kDa protein) (43 kDa postsynaptic protein).

TMF1_HUMAN
NC score	0.023833 (rank : 428)	θ value	0.47712 (rank : 286)
Query Neighborhood Hits	371	Target Neighborhood Hits	987	Shared Neighborhood Hits	29
SwissProt Accessions	P82094	Gene names	TMF1
Domain Architecture	No domain graphic available
Description	TATA element modulatory factor (TMF).

AMPH_HUMAN
NC score	0.023828 (rank : 429)	θ value	4.03905 (rank : 331)
Query Neighborhood Hits	371	Target Neighborhood Hits	455	Shared Neighborhood Hits	19
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

TRAK1_HUMAN
NC score	0.023732 (rank : 430)	θ value	0.62314 (rank : 294)
Query Neighborhood Hits	371	Target Neighborhood Hits	660	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UPV9, Q96B69	Gene names	TRAK1, KIAA1042, OIP106
Domain Architecture	No domain graphic available
Description	Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase- interacting protein).

VATH_MOUSE
NC score	0.023117 (rank : 431)	θ value	2.36792 (rank : 321)
Query Neighborhood Hits	371	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BVE3, Q921X8	Gene names	Atp6v1h
Domain Architecture	No domain graphic available
Description	Vacuolar ATP synthase subunit H (EC 3.6.3.14) (V-ATPase H subunit) (Vacuolar proton pump subunit H).

VATH_HUMAN
NC score	0.023078 (rank : 432)	θ value	2.36792 (rank : 320)
Query Neighborhood Hits	371	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UI12, Q6PK44, Q9H3E3, Q9Y300	Gene names	ATP6V1H
Domain Architecture
Description	Vacuolar ATP synthase subunit H (EC 3.6.3.14) (V-ATPase H subunit) (Vacuolar proton pump subunit H) (V-ATPase 50/57 kDa subunits) (Vacuolar proton pump subunit SFD) (VMA13) (Nef-binding protein 1) (NBP1).

REST_MOUSE
NC score	0.022712 (rank : 433)	θ value	1.38821 (rank : 301)
Query Neighborhood Hits	371	Target Neighborhood Hits	1506	Shared Neighborhood Hits	52
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

K0141_MOUSE
NC score	0.022690 (rank : 434)	θ value	2.36792 (rank : 314)
Query Neighborhood Hits	371	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q9DCV6, Q6A0B8	Gene names	Kiaa0141
Domain Architecture
Description	Protein KIAA0141.

WAPL_MOUSE
NC score	0.022427 (rank : 435)	θ value	3.0926 (rank : 330)
Query Neighborhood Hits	371	Target Neighborhood Hits	158	Shared Neighborhood Hits	7
SwissProt Accessions	Q65Z40, Q6ZQE9	Gene names	Wapal, Kiaa0261, Wapl
Domain Architecture	No domain graphic available
Description	Wings apart-like protein homolog (Dioxin-inducible factor 2) (DIF-2).

REL_HUMAN
NC score	0.021639 (rank : 436)	θ value	8.99809 (rank : 368)
Query Neighborhood Hits	371	Target Neighborhood Hits	31	Shared Neighborhood Hits	6
SwissProt Accessions	Q04864, Q2PNZ7, Q6LDY0	Gene names	REL
Domain Architecture
Description	C-Rel proto-oncogene protein (C-Rel protein).

WAPL_HUMAN
NC score	0.021176 (rank : 437)	θ value	1.81305 (rank : 307)
Query Neighborhood Hits	371	Target Neighborhood Hits	122	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z5K2, Q5VSK5, Q8IX10, Q92549	Gene names	WAPAL, FOE, KIAA0261, WAPL
Domain Architecture	No domain graphic available
Description	Wings apart-like protein homolog (Friend of EBNA2 protein).

BMS1_HUMAN
NC score	0.020892 (rank : 438)	θ value	2.36792 (rank : 311)
Query Neighborhood Hits	371	Target Neighborhood Hits	109	Shared Neighborhood Hits	4
SwissProt Accessions	Q14692, Q86XJ9	Gene names	BMS1L, KIAA0187
Domain Architecture
Description	Ribosome biogenesis protein BMS1 homolog.

AMPH_MOUSE
NC score	0.020609 (rank : 439)	θ value	2.36792 (rank : 309)
Query Neighborhood Hits	371	Target Neighborhood Hits	291	Shared Neighborhood Hits	14
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

RBM25_HUMAN
NC score	0.020487 (rank : 440)	θ value	2.36792 (rank : 317)
Query Neighborhood Hits	371	Target Neighborhood Hits	682	Shared Neighborhood Hits	23
SwissProt Accessions	P49756, Q9UEQ5, Q9UIE9	Gene names	RBM25, RNPC7
Domain Architecture	No domain graphic available
Description	Probable RNA-binding protein 25 (RNA-binding motif protein 25) (RNA- binding region-containing protein 7) (Protein S164).

ZN638_HUMAN
NC score	0.019949 (rank : 441)	θ value	1.81305 (rank : 308)
Query Neighborhood Hits	371	Target Neighborhood Hits	343	Shared Neighborhood Hits	14
SwissProt Accessions	Q14966, Q53R34, Q5XJ05, Q68DP3, Q6P2H2, Q7Z3T7, Q8NF92, Q8TCA1, Q9H2G1, Q9NP37	Gene names	ZNF638, NP220, ZFML
Domain Architecture	No domain graphic available
Description	Zinc finger protein 638 (Nuclear protein 220) (Zinc-finger matrin-like protein) (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL tumor antigen se33-1).

K1958_HUMAN
NC score	0.019735 (rank : 442)	θ value	1.38821 (rank : 300)
Query Neighborhood Hits	371	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N8K9, Q5T252, Q8TF43, Q96N02	Gene names	KIAA1958
Domain Architecture	No domain graphic available
Description	Protein KIAA1958.

GAB1_HUMAN
NC score	0.018058 (rank : 443)	θ value	2.36792 (rank : 313)
Query Neighborhood Hits	371	Target Neighborhood Hits	279	Shared Neighborhood Hits	12
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

EVI2A_MOUSE
NC score	0.017824 (rank : 444)	θ value	4.03905 (rank : 336)
Query Neighborhood Hits	371	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	P20934	Gene names	Evi2a, Evi-2, Evi-2a, Evi2
Domain Architecture
Description	EVI2A protein precursor (Ecotropic viral integration site 2A protein).

CCD46_HUMAN
NC score	0.016587 (rank : 445)	θ value	2.36792 (rank : 312)
Query Neighborhood Hits	371	Target Neighborhood Hits	1430	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

LRRK2_MOUSE
NC score	0.016246 (rank : 446)	θ value	0.0148317 (rank : 237)
Query Neighborhood Hits	371	Target Neighborhood Hits	1359	Shared Neighborhood Hits	38
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

K0319_HUMAN
NC score	0.016185 (rank : 447)	θ value	2.36792 (rank : 315)
Query Neighborhood Hits	371	Target Neighborhood Hits	154	Shared Neighborhood Hits	7
SwissProt Accessions	Q5VV43, Q9UJC8, Q9Y4G7	Gene names	KIAA0319
Domain Architecture	No domain graphic available
Description	Protein KIAA0319 precursor.

PCNT_MOUSE
NC score	0.013328 (rank : 448)	θ value	6.88961 (rank : 355)
Query Neighborhood Hits	371	Target Neighborhood Hits	1207	Shared Neighborhood Hits	36
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

LRRK2_HUMAN
NC score	0.012455 (rank : 449)	θ value	0.47712 (rank : 285)
Query Neighborhood Hits	371	Target Neighborhood Hits	1382	Shared Neighborhood Hits	30
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

TOP2A_MOUSE
NC score	0.011990 (rank : 450)	θ value	2.36792 (rank : 319)
Query Neighborhood Hits	371	Target Neighborhood Hits	101	Shared Neighborhood Hits	6
SwissProt Accessions	Q01320	Gene names	Top2a, Top-2, Top2
Domain Architecture
Description	DNA topoisomerase 2-alpha (EC 5.99.1.3) (DNA topoisomerase II, alpha isozyme).

B2L12_HUMAN
NC score	0.011779 (rank : 451)	θ value	8.99809 (rank : 361)
Query Neighborhood Hits	371	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HB09, Q3SY11, Q96I96, Q9HB08	Gene names	BCL2L12, BPR
Domain Architecture	No domain graphic available
Description	Bcl-2-related proline-rich protein (Bcl-2-like 12 protein).

TYDP1_MOUSE
NC score	0.009377 (rank : 452)	θ value	6.88961 (rank : 359)
Query Neighborhood Hits	371	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BJ37, Q8VE39	Gene names	Tdp1
Domain Architecture
Description	Tyrosyl-DNA phosphodiesterase 1 (EC 3.1.4.-) (Tyr-DNA phosphodiesterase 1).

MCRS1_HUMAN
NC score	0.007383 (rank : 453)	θ value	8.99809 (rank : 365)
Query Neighborhood Hits	371	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	Q96EZ8, O14742, O75497, Q6VN53	Gene names	MCRS1, MSP58
Domain Architecture
Description	Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle- regulated factor p78) (MCRS2).

ZN533_HUMAN
NC score	0.007269 (rank : 454)	θ value	6.88961 (rank : 360)
Query Neighborhood Hits	371	Target Neighborhood Hits	85	Shared Neighborhood Hits	5
SwissProt Accessions	Q569K4, Q49A04, Q6ZMZ7, Q8IY01, Q8N8H2, Q96DK4	Gene names	ZNF533
Domain Architecture	No domain graphic available
Description	Zinc finger protein 533.

LRP6_HUMAN
NC score	0.006339 (rank : 455)	θ value	6.88961 (rank : 352)
Query Neighborhood Hits	371	Target Neighborhood Hits	235	Shared Neighborhood Hits	12
SwissProt Accessions	O75581	Gene names	LRP6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

K0195_MOUSE
NC score	0.006158 (rank : 456)	θ value	8.99809 (rank : 363)
Query Neighborhood Hits	371	Target Neighborhood Hits	45	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TSH8, Q80U66, Q8BL05, Q8K0Q0, Q91VY1	Gene names	Kiaa0195
Domain Architecture	No domain graphic available
Description	Protein KIAA0195.

MARK2_HUMAN
NC score	0.006103 (rank : 457)	θ value	2.36792 (rank : 316)
Query Neighborhood Hits	371	Target Neighborhood Hits	1056	Shared Neighborhood Hits	31
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

LRP6_MOUSE
NC score	0.005844 (rank : 458)	θ value	6.88961 (rank : 353)
Query Neighborhood Hits	371	Target Neighborhood Hits	232	Shared Neighborhood Hits	12
SwissProt Accessions	O88572	Gene names	Lrp6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

EP400_MOUSE
NC score	0.005825 (rank : 459)	θ value	6.88961 (rank : 349)
Query Neighborhood Hits	371	Target Neighborhood Hits	592	Shared Neighborhood Hits	17
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

FURIN_MOUSE
NC score	0.005469 (rank : 460)	θ value	5.27518 (rank : 344)
Query Neighborhood Hits	371	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	P23188	Gene names	Furin, Fur, Pcsk3
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme) (Prohormone convertase 3).

FURIN_HUMAN
NC score	0.005449 (rank : 461)	θ value	5.27518 (rank : 343)
Query Neighborhood Hits	371	Target Neighborhood Hits	52	Shared Neighborhood Hits	3
SwissProt Accessions	P09958, Q14336, Q6LBS3	Gene names	FURIN, FUR, PACE
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme).

C2TA_MOUSE
NC score	0.004603 (rank : 462)	θ value	6.88961 (rank : 348)
Query Neighborhood Hits	371	Target Neighborhood Hits	131	Shared Neighborhood Hits	5
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

MYCPP_HUMAN
NC score	0.004151 (rank : 463)	θ value	8.99809 (rank : 366)
Query Neighborhood Hits	371	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	Q7Z401, Q14655, Q86T77, Q8IVX2, Q8NB93	Gene names	MYCPBP, IRLB
Domain Architecture	No domain graphic available
Description	C-myc promoter-binding protein.

PKP1_MOUSE
NC score	0.003488 (rank : 464)	θ value	6.88961 (rank : 356)
Query Neighborhood Hits	371	Target Neighborhood Hits	37	Shared Neighborhood Hits	2
SwissProt Accessions	P97350	Gene names	Pkp1
Domain Architecture
Description	Plakophilin-1.

RHBT1_HUMAN
NC score	0.002194 (rank : 465)	θ value	8.99809 (rank : 369)
Query Neighborhood Hits	371	Target Neighborhood Hits	262	Shared Neighborhood Hits	6
SwissProt Accessions	O94844	Gene names	RHOBTB1, KIAA0740
Domain Architecture
Description	Rho-related BTB domain-containing protein 1.

ST14_HUMAN
NC score	0.001125 (rank : 466)	θ value	6.88961 (rank : 357)
Query Neighborhood Hits	371	Target Neighborhood Hits	409	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y5Y6, Q9BS01, Q9H3S0, Q9HB36, Q9HCA3	Gene names	ST14, PRSS14, SNC19, TADG15
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein).

NEDD1_MOUSE
NC score	0.001054 (rank : 467)	θ value	6.88961 (rank : 354)
Query Neighborhood Hits	371	Target Neighborhood Hits	281	Shared Neighborhood Hits	4
SwissProt Accessions	P33215, Q6NXV3, Q8BN12, Q8BN86, Q8BQL9, Q9CWK2	Gene names	Nedd1, Nedd-1
Domain Architecture	No domain graphic available
Description	Protein NEDD1 (Neural precursor cell expressed developmentally down- regulated protein 1).

CETN2_HUMAN
NC score	0.000443 (rank : 468)	θ value	5.27518 (rank : 341)
Query Neighborhood Hits	371	Target Neighborhood Hits	213	Shared Neighborhood Hits	3
SwissProt Accessions	P41208, Q53XW1	Gene names	CETN2, CALT, CEN2
Domain Architecture
Description	Centrin-2 (Caltractin isoform 1).

CETN2_MOUSE
NC score	0.000333 (rank : 469)	θ value	5.27518 (rank : 342)
Query Neighborhood Hits	371	Target Neighborhood Hits	211	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R1K9, Q3UBB4, Q9CWM0	Gene names	Cetn2, Calt
Domain Architecture
Description	Centrin-2 (Caltractin isoform 1).

SPB5_HUMAN
NC score	-0.002122 (rank : 470)	θ value	8.99809 (rank : 370)
Query Neighborhood Hits	371	Target Neighborhood Hits	91	Shared Neighborhood Hits	3
SwissProt Accessions	P36952	Gene names	SERPINB5, PI5
Domain Architecture
Description	Serpin B5 precursor (Maspin) (Protease inhibitor 5).

PCDGI_HUMAN
NC score	-0.002746 (rank : 471)	θ value	3.0926 (rank : 329)
Query Neighborhood Hits	371	Target Neighborhood Hits	162	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y5F9, Q9Y5C5	Gene names	PCDHGB6
Domain Architecture
Description	Protocadherin gamma B6 precursor (PCDH-gamma-B6).

KIRR3_MOUSE
NC score	-0.003392 (rank : 472)	θ value	8.99809 (rank : 364)
Query Neighborhood Hits	371	Target Neighborhood Hits	292	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BR86, Q6P555, Q810H3, Q8BGQ5, Q8BRS8	Gene names	Kirrel3, Kiaa1867
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3).

PCDGH_HUMAN
NC score	-0.003642 (rank : 473)	θ value	8.99809 (rank : 367)
Query Neighborhood Hits	371	Target Neighborhood Hits	164	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y5G0, Q9Y5C6	Gene names	PCDHGB5
Domain Architecture
Description	Protocadherin gamma B5 precursor (PCDH-gamma-B5).

SUHW4_HUMAN
NC score	-0.005667 (rank : 474)	θ value	5.27518 (rank : 345)
Query Neighborhood Hits	371	Target Neighborhood Hits	860	Shared Neighborhood Hits	12
SwissProt Accessions	Q6N043, Q6MZM6, Q6N085, Q9H0U5, Q9HCI8, Q9NXS0	Gene names	SUHW4, KIAA1584
Domain Architecture	No domain graphic available
Description	Suppressor of hairy wing homolog 4.

ZN644_HUMAN
NC score	-0.006355 (rank : 475)	θ value	2.36792 (rank : 322)
Query Neighborhood Hits	371	Target Neighborhood Hits	704	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H582, Q5TCC0, Q6BEP7, Q6P446, Q6PI06, Q7LG67, Q9ULJ9	Gene names	ZNF644, KIAA1221, ZEP2
Domain Architecture	No domain graphic available
Description	Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2).

DRD4_MOUSE
NC score	-0.009544 (rank : 476)	θ value	4.03905 (rank : 335)
Query Neighborhood Hits	371	Target Neighborhood Hits	852	Shared Neighborhood Hits	2
SwissProt Accessions	P51436, O35838	Gene names	Drd4
Domain Architecture
Description	D(4) dopamine receptor (Dopamine D4 receptor) (D(2C) dopamine receptor).

GLI1_MOUSE
NC score	-0.011627 (rank : 477)	θ value	6.88961 (rank : 351)
Query Neighborhood Hits	371	Target Neighborhood Hits	785	Shared Neighborhood Hits	7
SwissProt Accessions	P47806, Q9QYK1	Gene names	Gli1, Gli
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI1 (Glioma-associated oncogene homolog).