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Network neighborhood for query Sequence : DDEF2_HUMAN

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DDEF2_HUMAN
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DDEF1_MOUSE
θ value	0 (rank : 1)	NC score	0.935238 (rank : 3)
Query Neighborhood Hits	599	Target Neighborhood Hits	592	Shared Neighborhood Hits	376
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_HUMAN
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	599	Target Neighborhood Hits	599	Shared Neighborhood Hits	599
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	0 (rank : 3)	NC score	0.983964 (rank : 2)
Query Neighborhood Hits	599	Target Neighborhood Hits	625	Shared Neighborhood Hits	500
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDFL1_HUMAN
θ value	0 (rank : 4)	NC score	0.899353 (rank : 4)
Query Neighborhood Hits	599	Target Neighborhood Hits	353	Shared Neighborhood Hits	263
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

DDFL1_MOUSE
θ value	0 (rank : 5)	NC score	0.896132 (rank : 5)
Query Neighborhood Hits	599	Target Neighborhood Hits	324	Shared Neighborhood Hits	260
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

CENB5_HUMAN
θ value	2.85459e-46 (rank : 6)	NC score	0.786941 (rank : 7)
Query Neighborhood Hits	599	Target Neighborhood Hits	395	Shared Neighborhood Hits	273
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CENB2_HUMAN
θ value	6.35935e-46 (rank : 7)	NC score	0.775289 (rank : 8)
Query Neighborhood Hits	599	Target Neighborhood Hits	425	Shared Neighborhood Hits	263
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENB1_HUMAN
θ value	2.50074e-42 (rank : 8)	NC score	0.788057 (rank : 6)
Query Neighborhood Hits	599	Target Neighborhood Hits	383	Shared Neighborhood Hits	264
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

CENG3_MOUSE
θ value	6.61148e-27 (rank : 9)	NC score	0.639325 (rank : 12)
Query Neighborhood Hits	599	Target Neighborhood Hits	467	Shared Neighborhood Hits	230
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_HUMAN
θ value	1.92365e-26 (rank : 10)	NC score	0.638601 (rank : 13)
Query Neighborhood Hits	599	Target Neighborhood Hits	455	Shared Neighborhood Hits	230
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG2_HUMAN
θ value	2.12685e-25 (rank : 11)	NC score	0.627690 (rank : 15)
Query Neighborhood Hits	599	Target Neighborhood Hits	471	Shared Neighborhood Hits	239
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

CENG2_MOUSE
θ value	2.77775e-25 (rank : 12)	NC score	0.629816 (rank : 14)
Query Neighborhood Hits	599	Target Neighborhood Hits	463	Shared Neighborhood Hits	239
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

CENG1_HUMAN
θ value	5.23862e-24 (rank : 13)	NC score	0.654151 (rank : 10)
Query Neighborhood Hits	599	Target Neighborhood Hits	544	Shared Neighborhood Hits	256
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

CENG1_MOUSE
θ value	1.5242e-23 (rank : 14)	NC score	0.659977 (rank : 9)
Query Neighborhood Hits	599	Target Neighborhood Hits	531	Shared Neighborhood Hits	259
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

CEND2_HUMAN
θ value	1.33526e-19 (rank : 15)	NC score	0.485135 (rank : 32)
Query Neighborhood Hits	599	Target Neighborhood Hits	166	Shared Neighborhood Hits	67
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

CEND1_HUMAN
θ value	1.63225e-17 (rank : 16)	NC score	0.494457 (rank : 30)
Query Neighborhood Hits	599	Target Neighborhood Hits	284	Shared Neighborhood Hits	75
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CEND1_MOUSE
θ value	6.20254e-17 (rank : 17)	NC score	0.492697 (rank : 31)
Query Neighborhood Hits	599	Target Neighborhood Hits	260	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CEND3_HUMAN
θ value	1.99529e-15 (rank : 18)	NC score	0.476871 (rank : 33)
Query Neighborhood Hits	599	Target Neighborhood Hits	275	Shared Neighborhood Hits	82
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CEND3_MOUSE
θ value	4.44505e-15 (rank : 19)	NC score	0.469856 (rank : 35)
Query Neighborhood Hits	599	Target Neighborhood Hits	228	Shared Neighborhood Hits	72
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

SMAP1_MOUSE
θ value	7.58209e-15 (rank : 20)	NC score	0.614673 (rank : 19)
Query Neighborhood Hits	599	Target Neighborhood Hits	120	Shared Neighborhood Hits	52
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

ARFG1_MOUSE
θ value	9.90251e-15 (rank : 21)	NC score	0.610386 (rank : 22)
Query Neighborhood Hits	599	Target Neighborhood Hits	51	Shared Neighborhood Hits	38
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

SMAP1_HUMAN
θ value	9.90251e-15 (rank : 22)	NC score	0.612902 (rank : 20)
Query Neighborhood Hits	599	Target Neighborhood Hits	98	Shared Neighborhood Hits	50
SwissProt Accessions	Q8IYB5, Q53H70, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4	Gene names	SMAP1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

ARFG1_HUMAN
θ value	2.20605e-14 (rank : 23)	NC score	0.596552 (rank : 25)
Query Neighborhood Hits	599	Target Neighborhood Hits	60	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N6T3, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0	Gene names	ARFGAP1, ARF1GAP
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

SMP1L_MOUSE
θ value	8.38298e-14 (rank : 24)	NC score	0.608990 (rank : 23)
Query Neighborhood Hits	599	Target Neighborhood Hits	70	Shared Neighborhood Hits	41
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

SMP1L_HUMAN
θ value	1.09485e-13 (rank : 25)	NC score	0.610966 (rank : 21)
Query Neighborhood Hits	599	Target Neighborhood Hits	74	Shared Neighborhood Hits	45
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

GIT2_MOUSE
θ value	1.42992e-13 (rank : 26)	NC score	0.642708 (rank : 11)
Query Neighborhood Hits	599	Target Neighborhood Hits	323	Shared Neighborhood Hits	242
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

GIT2_HUMAN
θ value	2.69671e-12 (rank : 27)	NC score	0.626367 (rank : 16)
Query Neighborhood Hits	599	Target Neighborhood Hits	381	Shared Neighborhood Hits	238
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

CENA1_HUMAN
θ value	6.00763e-12 (rank : 28)	NC score	0.601400 (rank : 24)
Query Neighborhood Hits	599	Target Neighborhood Hits	87	Shared Neighborhood Hits	49
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

GIT1_HUMAN
θ value	2.98157e-11 (rank : 29)	NC score	0.620988 (rank : 17)
Query Neighborhood Hits	599	Target Neighborhood Hits	336	Shared Neighborhood Hits	245
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

GIT1_MOUSE
θ value	2.98157e-11 (rank : 30)	NC score	0.620676 (rank : 18)
Query Neighborhood Hits	599	Target Neighborhood Hits	341	Shared Neighborhood Hits	243
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

CENA2_MOUSE
θ value	2.52405e-10 (rank : 31)	NC score	0.573441 (rank : 26)
Query Neighborhood Hits	599	Target Neighborhood Hits	68	Shared Neighborhood Hits	45
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

ARFG3_MOUSE
θ value	4.30538e-10 (rank : 32)	NC score	0.570076 (rank : 28)
Query Neighborhood Hits	599	Target Neighborhood Hits	80	Shared Neighborhood Hits	39
SwissProt Accessions	Q9D8S3, Q99KN8	Gene names	Arfgap3
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ARFG3_HUMAN
θ value	5.62301e-10 (rank : 33)	NC score	0.573149 (rank : 27)
Query Neighborhood Hits	599	Target Neighborhood Hits	56	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

CENA2_HUMAN
θ value	5.62301e-10 (rank : 34)	NC score	0.565025 (rank : 29)
Query Neighborhood Hits	599	Target Neighborhood Hits	83	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

DP13A_HUMAN
θ value	5.62301e-10 (rank : 35)	NC score	0.277271 (rank : 242)
Query Neighborhood Hits	599	Target Neighborhood Hits	107	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13A_MOUSE
θ value	3.64472e-09 (rank : 36)	NC score	0.274481 (rank : 245)
Query Neighborhood Hits	599	Target Neighborhood Hits	96	Shared Neighborhood Hits	20
SwissProt Accessions	Q8K3H0, Q3UJP7, Q69ZJ9, Q8BWZ8, Q8VCJ8, Q9CUW4	Gene names	Appl1, Dip13a, Kiaa1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

ANK3_HUMAN
θ value	2.36244e-08 (rank : 37)	NC score	0.416312 (rank : 72)
Query Neighborhood Hits	599	Target Neighborhood Hits	853	Shared Neighborhood Hits	268
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

ANK1_MOUSE
θ value	7.59969e-07 (rank : 38)	NC score	0.423255 (rank : 55)
Query Neighborhood Hits	599	Target Neighborhood Hits	430	Shared Neighborhood Hits	236
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

ITSN1_MOUSE
θ value	7.59969e-07 (rank : 39)	NC score	0.201433 (rank : 331)
Query Neighborhood Hits	599	Target Neighborhood Hits	1669	Shared Neighborhood Hits	274
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ANK1_HUMAN
θ value	9.92553e-07 (rank : 40)	NC score	0.424516 (rank : 52)
Query Neighborhood Hits	599	Target Neighborhood Hits	416	Shared Neighborhood Hits	235
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

DP13B_MOUSE
θ value	9.92553e-07 (rank : 41)	NC score	0.267412 (rank : 255)
Query Neighborhood Hits	599	Target Neighborhood Hits	58	Shared Neighborhood Hits	26
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

ANR22_HUMAN
θ value	1.29631e-06 (rank : 42)	NC score	0.454309 (rank : 37)
Query Neighborhood Hits	599	Target Neighborhood Hits	243	Shared Neighborhood Hits	212
SwissProt Accessions	Q5VYY1, Q8WU06	Gene names	ANKRD22
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 22.

OPHN1_MOUSE
θ value	2.88788e-06 (rank : 43)	NC score	0.215995 (rank : 317)
Query Neighborhood Hits	599	Target Neighborhood Hits	174	Shared Neighborhood Hits	34
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

ANK2_HUMAN
θ value	3.77169e-06 (rank : 44)	NC score	0.399939 (rank : 106)
Query Neighborhood Hits	599	Target Neighborhood Hits	1615	Shared Neighborhood Hits	333
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

OPHN1_HUMAN
θ value	6.43352e-06 (rank : 45)	NC score	0.194994 (rank : 348)
Query Neighborhood Hits	599	Target Neighborhood Hits	161	Shared Neighborhood Hits	34
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

ITSN1_HUMAN
θ value	8.40245e-06 (rank : 46)	NC score	0.194128 (rank : 350)
Query Neighborhood Hits	599	Target Neighborhood Hits	1757	Shared Neighborhood Hits	268
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

SH3G1_HUMAN
θ value	8.40245e-06 (rank : 47)	NC score	0.270971 (rank : 249)
Query Neighborhood Hits	599	Target Neighborhood Hits	307	Shared Neighborhood Hits	158
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

ITSN2_HUMAN
θ value	1.09739e-05 (rank : 48)	NC score	0.201199 (rank : 333)
Query Neighborhood Hits	599	Target Neighborhood Hits	1173	Shared Neighborhood Hits	231
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

SH3G1_MOUSE
θ value	1.09739e-05 (rank : 49)	NC score	0.271112 (rank : 248)
Query Neighborhood Hits	599	Target Neighborhood Hits	291	Shared Neighborhood Hits	159
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

STAM2_MOUSE
θ value	1.09739e-05 (rank : 50)	NC score	0.253769 (rank : 272)
Query Neighborhood Hits	599	Target Neighborhood Hits	285	Shared Neighborhood Hits	154
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

ITSN2_MOUSE
θ value	2.44474e-05 (rank : 51)	NC score	0.193909 (rank : 351)
Query Neighborhood Hits	599	Target Neighborhood Hits	1371	Shared Neighborhood Hits	234
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

CSKI1_HUMAN
θ value	4.1701e-05 (rank : 52)	NC score	0.414253 (rank : 80)
Query Neighborhood Hits	599	Target Neighborhood Hits	997	Shared Neighborhood Hits	350
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

SH3K1_HUMAN
θ value	4.1701e-05 (rank : 53)	NC score	0.292761 (rank : 234)
Query Neighborhood Hits	599	Target Neighborhood Hits	341	Shared Neighborhood Hits	170
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

ANKR6_HUMAN
θ value	5.44631e-05 (rank : 54)	NC score	0.440470 (rank : 40)
Query Neighborhood Hits	599	Target Neighborhood Hits	439	Shared Neighborhood Hits	248
SwissProt Accessions	Q9Y2G4, Q9NU24, Q9UFQ9	Gene names	ANKRD6, KIAA0957
Domain Architecture
Description	Ankyrin repeat domain-containing protein 6.

CSKI1_MOUSE
θ value	5.44631e-05 (rank : 55)	NC score	0.413577 (rank : 84)
Query Neighborhood Hits	599	Target Neighborhood Hits	1031	Shared Neighborhood Hits	338
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

MYO1E_HUMAN
θ value	5.44631e-05 (rank : 56)	NC score	0.122146 (rank : 418)
Query Neighborhood Hits	599	Target Neighborhood Hits	293	Shared Neighborhood Hits	150
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

MYPT1_HUMAN
θ value	5.44631e-05 (rank : 57)	NC score	0.419149 (rank : 65)
Query Neighborhood Hits	599	Target Neighborhood Hits	723	Shared Neighborhood Hits	268
SwissProt Accessions	O14974, Q86WU3, Q8NFR6, Q9BYH0	Gene names	PPP1R12A, MBS, MYPT1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit).

MYPT1_MOUSE
θ value	5.44631e-05 (rank : 58)	NC score	0.427810 (rank : 50)
Query Neighborhood Hits	599	Target Neighborhood Hits	539	Shared Neighborhood Hits	257
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

SH3K1_MOUSE
θ value	5.44631e-05 (rank : 59)	NC score	0.290193 (rank : 235)
Query Neighborhood Hits	599	Target Neighborhood Hits	332	Shared Neighborhood Hits	169
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

ANR42_HUMAN
θ value	7.1131e-05 (rank : 60)	NC score	0.430233 (rank : 47)
Query Neighborhood Hits	599	Target Neighborhood Hits	284	Shared Neighborhood Hits	228
SwissProt Accessions	Q8N9B4, Q49A49	Gene names	ANKRD42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

ANR42_MOUSE
θ value	7.1131e-05 (rank : 61)	NC score	0.428337 (rank : 49)
Query Neighborhood Hits	599	Target Neighborhood Hits	334	Shared Neighborhood Hits	235
SwissProt Accessions	Q3V096, Q8BX55, Q8BZT3, Q8C0T6, Q8C0X5	Gene names	Ankrd42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

ANKR1_MOUSE
θ value	9.29e-05 (rank : 62)	NC score	0.422025 (rank : 57)
Query Neighborhood Hits	599	Target Neighborhood Hits	316	Shared Neighborhood Hits	233
SwissProt Accessions	Q9CR42, O55014, Q3UIF7, Q3UJ39, Q792Q9	Gene names	Ankrd1, Carp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein).

CSKI2_HUMAN
θ value	9.29e-05 (rank : 63)	NC score	0.421918 (rank : 58)
Query Neighborhood Hits	599	Target Neighborhood Hits	747	Shared Neighborhood Hits	326
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CSKI2_MOUSE
θ value	9.29e-05 (rank : 64)	NC score	0.421586 (rank : 59)
Query Neighborhood Hits	599	Target Neighborhood Hits	812	Shared Neighborhood Hits	318
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

OSBP1_HUMAN
θ value	9.29e-05 (rank : 65)	NC score	0.121536 (rank : 419)
Query Neighborhood Hits	599	Target Neighborhood Hits	180	Shared Neighborhood Hits	46
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

AHI1_MOUSE
θ value	0.000121331 (rank : 66)	NC score	0.180841 (rank : 369)
Query Neighborhood Hits	599	Target Neighborhood Hits	496	Shared Neighborhood Hits	157
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

DAPK1_MOUSE
θ value	0.000121331 (rank : 67)	NC score	0.186703 (rank : 363)
Query Neighborhood Hits	599	Target Neighborhood Hits	1138	Shared Neighborhood Hits	250
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

MIB1_HUMAN
θ value	0.000121331 (rank : 68)	NC score	0.387982 (rank : 128)
Query Neighborhood Hits	599	Target Neighborhood Hits	470	Shared Neighborhood Hits	234
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

MIB1_MOUSE
θ value	0.000121331 (rank : 69)	NC score	0.388066 (rank : 127)
Query Neighborhood Hits	599	Target Neighborhood Hits	471	Shared Neighborhood Hits	235
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

OSTF1_HUMAN
θ value	0.000121331 (rank : 70)	NC score	0.453022 (rank : 38)
Query Neighborhood Hits	599	Target Neighborhood Hits	466	Shared Neighborhood Hits	348
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

SH3G3_MOUSE
θ value	0.000121331 (rank : 71)	NC score	0.270540 (rank : 251)
Query Neighborhood Hits	599	Target Neighborhood Hits	236	Shared Neighborhood Hits	149
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

AN36B_HUMAN
θ value	0.000158464 (rank : 72)	NC score	0.389949 (rank : 126)
Query Neighborhood Hits	599	Target Neighborhood Hits	294	Shared Neighborhood Hits	227
SwissProt Accessions	Q8N2N9, Q6IPR0	Gene names	ANKRD36B
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 36B.

ANR28_MOUSE
θ value	0.000158464 (rank : 73)	NC score	0.413710 (rank : 81)
Query Neighborhood Hits	599	Target Neighborhood Hits	314	Shared Neighborhood Hits	232
SwissProt Accessions	Q505D1	Gene names	Ankrd28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ANR46_HUMAN
θ value	0.000158464 (rank : 74)	NC score	0.439501 (rank : 41)
Query Neighborhood Hits	599	Target Neighborhood Hits	281	Shared Neighborhood Hits	223
SwissProt Accessions	Q86W74, Q6P9B7	Gene names	ANKRD46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

ARHG7_HUMAN
θ value	0.000158464 (rank : 75)	NC score	0.236707 (rank : 294)
Query Neighborhood Hits	599	Target Neighborhood Hits	347	Shared Neighborhood Hits	171
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

DAPK1_HUMAN
θ value	0.000158464 (rank : 76)	NC score	0.179575 (rank : 370)
Query Neighborhood Hits	599	Target Neighborhood Hits	1130	Shared Neighborhood Hits	248
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

IKBB_MOUSE
θ value	0.000158464 (rank : 77)	NC score	0.419477 (rank : 64)
Query Neighborhood Hits	599	Target Neighborhood Hits	284	Shared Neighborhood Hits	225
SwissProt Accessions	Q60778, Q9D6L5	Gene names	Nfkbib, Ikbb
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B).

MYO1F_MOUSE
θ value	0.000158464 (rank : 78)	NC score	0.123716 (rank : 414)
Query Neighborhood Hits	599	Target Neighborhood Hits	262	Shared Neighborhood Hits	148
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

OSTF1_MOUSE
θ value	0.000158464 (rank : 79)	NC score	0.467604 (rank : 36)
Query Neighborhood Hits	599	Target Neighborhood Hits	467	Shared Neighborhood Hits	347
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

SH3G2_MOUSE
θ value	0.000158464 (rank : 80)	NC score	0.268206 (rank : 254)
Query Neighborhood Hits	599	Target Neighborhood Hits	319	Shared Neighborhood Hits	159
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

AHI1_HUMAN
θ value	0.00020696 (rank : 81)	NC score	0.181434 (rank : 368)
Query Neighborhood Hits	599	Target Neighborhood Hits	537	Shared Neighborhood Hits	157
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ANR44_HUMAN
θ value	0.00020696 (rank : 82)	NC score	0.416203 (rank : 73)
Query Neighborhood Hits	599	Target Neighborhood Hits	318	Shared Neighborhood Hits	231
SwissProt Accessions	Q8N8A2, Q6P480, Q86VL5, Q8IZ72, Q9UFA4	Gene names	ANKRD44
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 44.

ASB2_MOUSE
θ value	0.00020696 (rank : 83)	NC score	0.399026 (rank : 109)
Query Neighborhood Hits	599	Target Neighborhood Hits	321	Shared Neighborhood Hits	230
SwissProt Accessions	Q8K0L0, Q9CTH4, Q9WV73	Gene names	Asb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 2 (ASB-2).

PA2G6_MOUSE
θ value	0.00020696 (rank : 84)	NC score	0.422434 (rank : 56)
Query Neighborhood Hits	599	Target Neighborhood Hits	293	Shared Neighborhood Hits	231
SwissProt Accessions	P97819, Q99LA9, Q9JK61	Gene names	Pla2g6
Domain Architecture
Description	85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4) (iPLA2) (CaI- PLA2) (Group VI phospholipase A2) (GVI PLA2).

PSD10_HUMAN
θ value	0.00020696 (rank : 85)	NC score	0.432462 (rank : 45)
Query Neighborhood Hits	599	Target Neighborhood Hits	301	Shared Neighborhood Hits	231
SwissProt Accessions	O75832	Gene names	PSMD10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

ANR10_HUMAN
θ value	0.000270298 (rank : 86)	NC score	0.428682 (rank : 48)
Query Neighborhood Hits	599	Target Neighborhood Hits	289	Shared Neighborhood Hits	227
SwissProt Accessions	Q9NXR5	Gene names	ANKRD10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

ANR52_MOUSE
θ value	0.000270298 (rank : 87)	NC score	0.416411 (rank : 71)
Query Neighborhood Hits	599	Target Neighborhood Hits	318	Shared Neighborhood Hits	231
SwissProt Accessions	Q8BTI7	Gene names	Ankrd52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ASB2_HUMAN
θ value	0.000270298 (rank : 88)	NC score	0.405627 (rank : 92)
Query Neighborhood Hits	599	Target Neighborhood Hits	309	Shared Neighborhood Hits	229
SwissProt Accessions	Q96Q27, Q9NSU5, Q9Y567	Gene names	ASB2
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 2 (ASB-2).

CD2AP_HUMAN
θ value	0.000270298 (rank : 89)	NC score	0.287769 (rank : 237)
Query Neighborhood Hits	599	Target Neighborhood Hits	315	Shared Neighborhood Hits	171
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

PA2G6_HUMAN
θ value	0.000270298 (rank : 90)	NC score	0.418903 (rank : 66)
Query Neighborhood Hits	599	Target Neighborhood Hits	284	Shared Neighborhood Hits	229
SwissProt Accessions	O60733, O75645, Q8N452, Q9UG29, Q9UIT0, Q9Y671	Gene names	PLA2G6, IPLA2
Domain Architecture
Description	85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4) (iPLA2) (CaI- PLA2) (Group VI phospholipase A2) (GVI PLA2).

SH3G3_HUMAN
θ value	0.000270298 (rank : 91)	NC score	0.267130 (rank : 256)
Query Neighborhood Hits	599	Target Neighborhood Hits	222	Shared Neighborhood Hits	145
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

TRPA1_MOUSE
θ value	0.000270298 (rank : 92)	NC score	0.394263 (rank : 121)
Query Neighborhood Hits	599	Target Neighborhood Hits	343	Shared Neighborhood Hits	232
SwissProt Accessions	Q8BLA8	Gene names	Trpa1, Anktm1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1).

ANR52_HUMAN
θ value	0.00035302 (rank : 93)	NC score	0.415420 (rank : 78)
Query Neighborhood Hits	599	Target Neighborhood Hits	322	Shared Neighborhood Hits	231
SwissProt Accessions	Q8NB46	Gene names	ANKRD52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ASB16_HUMAN
θ value	0.00035302 (rank : 94)	NC score	0.409722 (rank : 87)
Query Neighborhood Hits	599	Target Neighborhood Hits	286	Shared Neighborhood Hits	228
SwissProt Accessions	Q96NS5, Q8WXK0	Gene names	ASB16
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 16 (ASB-16).

CT086_HUMAN
θ value	0.00035302 (rank : 95)	NC score	0.473004 (rank : 34)
Query Neighborhood Hits	599	Target Neighborhood Hits	277	Shared Neighborhood Hits	227
SwissProt Accessions	Q9BZ19, Q4VXE6	Gene names	C20orf86
Domain Architecture
Description	Putative uncharacterized protein C20orf86.

MYPT2_HUMAN
θ value	0.00035302 (rank : 96)	NC score	0.415948 (rank : 75)
Query Neighborhood Hits	599	Target Neighborhood Hits	707	Shared Neighborhood Hits	262
SwissProt Accessions	O60237, Q8N179, Q9HCB7, Q9HCB8	Gene names	PPP1R12B, MYPT2
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase- targeting subunit 2) (Myosin phosphatase target subunit 2).

PSD10_MOUSE
θ value	0.00035302 (rank : 97)	NC score	0.430401 (rank : 46)
Query Neighborhood Hits	599	Target Neighborhood Hits	293	Shared Neighborhood Hits	229
SwissProt Accessions	Q9Z2X2, Q9D7N8	Gene names	Psmd10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

ZDH13_MOUSE
θ value	0.00035302 (rank : 98)	NC score	0.358210 (rank : 180)
Query Neighborhood Hits	599	Target Neighborhood Hits	329	Shared Neighborhood Hits	229
SwissProt Accessions	Q9CWU2, Q3UK32, Q3UKV1	Gene names	Zdhhc13, Hip14l
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC13 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein).

ANR28_HUMAN
θ value	0.000461057 (rank : 99)	NC score	0.412213 (rank : 86)
Query Neighborhood Hits	599	Target Neighborhood Hits	314	Shared Neighborhood Hits	232
SwissProt Accessions	O15084, Q6ULS0, Q6ZT57	Gene names	ANKRD28, KIAA0379
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ANR45_MOUSE
θ value	0.000461057 (rank : 100)	NC score	0.373513 (rank : 152)
Query Neighborhood Hits	599	Target Neighborhood Hits	204	Shared Neighborhood Hits	170
SwissProt Accessions	Q810N6	Gene names	Ankrd45
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 45.

ARHG7_MOUSE
θ value	0.000461057 (rank : 101)	NC score	0.237349 (rank : 293)
Query Neighborhood Hits	599	Target Neighborhood Hits	396	Shared Neighborhood Hits	176
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

AN36A_HUMAN
θ value	0.000602161 (rank : 102)	NC score	0.387264 (rank : 130)
Query Neighborhood Hits	599	Target Neighborhood Hits	271	Shared Neighborhood Hits	224
SwissProt Accessions	Q6UX02, Q86X62	Gene names	ANKRD36, ANKRD36A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 36A.

ANR10_MOUSE
θ value	0.000602161 (rank : 103)	NC score	0.424152 (rank : 54)
Query Neighborhood Hits	599	Target Neighborhood Hits	273	Shared Neighborhood Hits	225
SwissProt Accessions	Q99LW0	Gene names	Ankrd10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

ANR46_MOUSE
θ value	0.000602161 (rank : 104)	NC score	0.427384 (rank : 51)
Query Neighborhood Hits	599	Target Neighborhood Hits	274	Shared Neighborhood Hits	218
SwissProt Accessions	Q8BTZ5, Q1LZK9, Q8BV97	Gene names	Ankrd46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

OSBL3_HUMAN
θ value	0.000602161 (rank : 105)	NC score	0.102741 (rank : 447)
Query Neighborhood Hits	599	Target Neighborhood Hits	93	Shared Neighborhood Hits	30
SwissProt Accessions	Q9H4L5, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9UED6	Gene names	OSBPL3, KIAA0704, ORP3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

PACN1_HUMAN
θ value	0.000602161 (rank : 106)	NC score	0.238826 (rank : 289)
Query Neighborhood Hits	599	Target Neighborhood Hits	320	Shared Neighborhood Hits	154
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	0.000602161 (rank : 107)	NC score	0.238693 (rank : 290)
Query Neighborhood Hits	599	Target Neighborhood Hits	283	Shared Neighborhood Hits	152
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	0.000602161 (rank : 108)	NC score	0.237399 (rank : 292)
Query Neighborhood Hits	599	Target Neighborhood Hits	339	Shared Neighborhood Hits	163
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

A20A1_HUMAN
θ value	0.000786445 (rank : 109)	NC score	0.339682 (rank : 201)
Query Neighborhood Hits	599	Target Neighborhood Hits	698	Shared Neighborhood Hits	261
SwissProt Accessions	Q5TYW2, Q9H0H6	Gene names	ANKRD20A1, ANKRD20A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A1.

A20A3_HUMAN
θ value	0.000786445 (rank : 110)	NC score	0.340650 (rank : 199)
Query Neighborhood Hits	599	Target Neighborhood Hits	692	Shared Neighborhood Hits	261
SwissProt Accessions	Q5VUR7	Gene names	ANKRD20A3
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A3.

A20A4_HUMAN
θ value	0.000786445 (rank : 111)	NC score	0.338684 (rank : 204)
Query Neighborhood Hits	599	Target Neighborhood Hits	710	Shared Neighborhood Hits	263
SwissProt Accessions	Q5SQ80	Gene names	ANKRD20A4
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A4.

ASB16_MOUSE
θ value	0.000786445 (rank : 112)	NC score	0.408905 (rank : 88)
Query Neighborhood Hits	599	Target Neighborhood Hits	306	Shared Neighborhood Hits	229
SwissProt Accessions	Q8VHS5, Q8BYT0	Gene names	Asb16
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 16 (ASB-16).

NOTC3_MOUSE
θ value	0.000786445 (rank : 113)	NC score	0.200473 (rank : 335)
Query Neighborhood Hits	599	Target Neighborhood Hits	975	Shared Neighborhood Hits	261
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

A20A2_HUMAN
θ value	0.00102713 (rank : 114)	NC score	0.340196 (rank : 200)
Query Neighborhood Hits	599	Target Neighborhood Hits	716	Shared Neighborhood Hits	264
SwissProt Accessions	Q4UJ75	Gene names	ANKRD20A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A2.

ARHG6_HUMAN
θ value	0.00102713 (rank : 115)	NC score	0.227706 (rank : 302)
Query Neighborhood Hits	599	Target Neighborhood Hits	376	Shared Neighborhood Hits	165
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	0.00102713 (rank : 116)	NC score	0.232167 (rank : 298)
Query Neighborhood Hits	599	Target Neighborhood Hits	394	Shared Neighborhood Hits	169
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ASB8_HUMAN
θ value	0.00102713 (rank : 117)	NC score	0.420044 (rank : 63)
Query Neighborhood Hits	599	Target Neighborhood Hits	294	Shared Neighborhood Hits	229
SwissProt Accessions	Q9H765, Q547Q2	Gene names	ASB8
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 8 (ASB-8).

DP13B_HUMAN
θ value	0.00102713 (rank : 118)	NC score	0.249308 (rank : 281)
Query Neighborhood Hits	599	Target Neighborhood Hits	58	Shared Neighborhood Hits	22
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

HRBL_MOUSE
θ value	0.00102713 (rank : 119)	NC score	0.327428 (rank : 212)
Query Neighborhood Hits	599	Target Neighborhood Hits	269	Shared Neighborhood Hits	63
SwissProt Accessions	Q80WC7, Q8BKS5, Q99J67	Gene names	Hrbl, Rabr
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

ILK1_HUMAN
θ value	0.00102713 (rank : 120)	NC score	0.260050 (rank : 266)
Query Neighborhood Hits	599	Target Neighborhood Hits	857	Shared Neighborhood Hits	244
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	0.00102713 (rank : 121)	NC score	0.269282 (rank : 253)
Query Neighborhood Hits	599	Target Neighborhood Hits	848	Shared Neighborhood Hits	244
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

NCF2_HUMAN
θ value	0.00102713 (rank : 122)	NC score	0.276687 (rank : 244)
Query Neighborhood Hits	599	Target Neighborhood Hits	229	Shared Neighborhood Hits	141
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

PACN2_MOUSE
θ value	0.00102713 (rank : 123)	NC score	0.235475 (rank : 295)
Query Neighborhood Hits	599	Target Neighborhood Hits	382	Shared Neighborhood Hits	165
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

SH3G2_HUMAN
θ value	0.00102713 (rank : 124)	NC score	0.262520 (rank : 263)
Query Neighborhood Hits	599	Target Neighborhood Hits	324	Shared Neighborhood Hits	157
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SNX18_MOUSE
θ value	0.00102713 (rank : 125)	NC score	0.199929 (rank : 337)
Query Neighborhood Hits	599	Target Neighborhood Hits	198	Shared Neighborhood Hits	114
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

TNI3K_MOUSE
θ value	0.00102713 (rank : 126)	NC score	0.208931 (rank : 324)
Query Neighborhood Hits	599	Target Neighborhood Hits	1079	Shared Neighborhood Hits	250
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

ANR37_HUMAN
θ value	0.00134147 (rank : 127)	NC score	0.438605 (rank : 43)
Query Neighborhood Hits	599	Target Neighborhood Hits	247	Shared Neighborhood Hits	216
SwissProt Accessions	Q7Z713	Gene names	ANKRD37, LPR2BP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37 (Low-density lipoprotein receptor-related protein 2-binding protein) (hLrp2bp).

ASB8_MOUSE
θ value	0.00134147 (rank : 128)	NC score	0.420094 (rank : 62)
Query Neighborhood Hits	599	Target Neighborhood Hits	293	Shared Neighborhood Hits	229
SwissProt Accessions	Q91ZT9, Q8R178	Gene names	Asb8
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 8 (ASB-8).

CD2AP_MOUSE
θ value	0.00134147 (rank : 129)	NC score	0.284981 (rank : 238)
Query Neighborhood Hits	599	Target Neighborhood Hits	336	Shared Neighborhood Hits	186
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

MYO1F_HUMAN
θ value	0.00134147 (rank : 130)	NC score	0.122219 (rank : 416)
Query Neighborhood Hits	599	Target Neighborhood Hits	275	Shared Neighborhood Hits	158
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

NUPL_HUMAN
θ value	0.00134147 (rank : 131)	NC score	0.377158 (rank : 142)
Query Neighborhood Hits	599	Target Neighborhood Hits	68	Shared Neighborhood Hits	38
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).

NUPL_MOUSE
θ value	0.00134147 (rank : 132)	NC score	0.373839 (rank : 151)
Query Neighborhood Hits	599	Target Neighborhood Hits	113	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K2K6, O70448, Q8BQL5, Q8CDK9	Gene names	Hrb, Rip
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein homolog).

STAM2_HUMAN
θ value	0.00134147 (rank : 133)	NC score	0.242611 (rank : 287)
Query Neighborhood Hits	599	Target Neighborhood Hits	288	Shared Neighborhood Hits	158
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

HECD1_HUMAN
θ value	0.00175202 (rank : 134)	NC score	0.339571 (rank : 203)
Query Neighborhood Hits	599	Target Neighborhood Hits	371	Shared Neighborhood Hits	229
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

HRBL_HUMAN
θ value	0.00175202 (rank : 135)	NC score	0.334334 (rank : 205)
Query Neighborhood Hits	599	Target Neighborhood Hits	179	Shared Neighborhood Hits	54
SwissProt Accessions	O95081, O75429, Q96AB9, Q96GL4	Gene names	HRBL, RABR
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

NOTC4_HUMAN
θ value	0.00175202 (rank : 136)	NC score	0.218650 (rank : 316)
Query Neighborhood Hits	599	Target Neighborhood Hits	905	Shared Neighborhood Hits	236
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

PCLO_HUMAN
θ value	0.00175202 (rank : 137)	NC score	0.082972 (rank : 481)
Query Neighborhood Hits	599	Target Neighborhood Hits	2046	Shared Neighborhood Hits	205
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

SNX18_HUMAN
θ value	0.00175202 (rank : 138)	NC score	0.196063 (rank : 347)
Query Neighborhood Hits	599	Target Neighborhood Hits	207	Shared Neighborhood Hits	112
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

ANR35_HUMAN
θ value	0.00228821 (rank : 139)	NC score	0.390083 (rank : 125)
Query Neighborhood Hits	599	Target Neighborhood Hits	784	Shared Neighborhood Hits	271
SwissProt Accessions	Q8N283, Q3MJ10, Q96LS3	Gene names	ANKRD35
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 35.

ASB10_HUMAN
θ value	0.00228821 (rank : 140)	NC score	0.417193 (rank : 69)
Query Neighborhood Hits	599	Target Neighborhood Hits	291	Shared Neighborhood Hits	231
SwissProt Accessions	Q8WXI3	Gene names	ASB10
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

CLPB_HUMAN
θ value	0.00228821 (rank : 141)	NC score	0.296800 (rank : 231)
Query Neighborhood Hits	599	Target Neighborhood Hits	265	Shared Neighborhood Hits	196
SwissProt Accessions	Q9H078, Q8ND11, Q9H8Y0	Gene names	CLPB, SKD3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

IKBE_MOUSE
θ value	0.00228821 (rank : 142)	NC score	0.401702 (rank : 99)
Query Neighborhood Hits	599	Target Neighborhood Hits	308	Shared Neighborhood Hits	233
SwissProt Accessions	O54910, Q3U686, Q9CZZ9, Q9D7U3	Gene names	Nfkbie, Ikbe
Domain Architecture
Description	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKB-E).

ILK_MOUSE
θ value	0.00228821 (rank : 143)	NC score	0.257327 (rank : 268)
Query Neighborhood Hits	599	Target Neighborhood Hits	858	Shared Neighborhood Hits	246
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

NOTC3_HUMAN
θ value	0.00228821 (rank : 144)	NC score	0.198246 (rank : 344)
Query Neighborhood Hits	599	Target Neighborhood Hits	1062	Shared Neighborhood Hits	254
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

ZDH17_HUMAN
θ value	0.00228821 (rank : 145)	NC score	0.370102 (rank : 159)
Query Neighborhood Hits	599	Target Neighborhood Hits	334	Shared Neighborhood Hits	229
SwissProt Accessions	Q8IUH5, O75407, Q7Z2I0, Q86W89, Q86YK0, Q9P088, Q9UPZ8	Gene names	ZDHHC17, HIP14, HIP3, KIAA0946
Domain Architecture
Description	Palmitoyltransferase ZDHHC17 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 17) (DHHC-17) (Huntingtin-interacting protein 14) (Huntingtin-interacting protein 3) (Huntingtin-interacting protein HYPH) (Putative NF-kappa-B-activating protein 205) (Putative MAPK- activating protein PM11).

ANR39_MOUSE
θ value	0.00298849 (rank : 146)	NC score	0.437798 (rank : 44)
Query Neighborhood Hits	599	Target Neighborhood Hits	284	Shared Neighborhood Hits	227
SwissProt Accessions	Q9D2X0	Gene names	Ankrd39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ASB3_MOUSE
θ value	0.00298849 (rank : 147)	NC score	0.402544 (rank : 97)
Query Neighborhood Hits	599	Target Neighborhood Hits	316	Shared Neighborhood Hits	229
SwissProt Accessions	Q9WV72	Gene names	Asb3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

BARD1_HUMAN
θ value	0.00298849 (rank : 148)	NC score	0.393119 (rank : 122)
Query Neighborhood Hits	599	Target Neighborhood Hits	427	Shared Neighborhood Hits	228
SwissProt Accessions	Q99728, O43574	Gene names	BARD1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

IKBB_HUMAN
θ value	0.00298849 (rank : 149)	NC score	0.400745 (rank : 102)
Query Neighborhood Hits	599	Target Neighborhood Hits	284	Shared Neighborhood Hits	229
SwissProt Accessions	Q15653, Q96BJ7	Gene names	NFKBIB, IKBB, TRIP9
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9).

SHAN1_HUMAN
θ value	0.00298849 (rank : 150)	NC score	0.415637 (rank : 77)
Query Neighborhood Hits	599	Target Neighborhood Hits	1041	Shared Neighborhood Hits	401
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

TNI3K_HUMAN
θ value	0.00298849 (rank : 151)	NC score	0.212561 (rank : 320)
Query Neighborhood Hits	599	Target Neighborhood Hits	1084	Shared Neighborhood Hits	249
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

VINEX_HUMAN
θ value	0.00298849 (rank : 152)	NC score	0.252757 (rank : 273)
Query Neighborhood Hits	599	Target Neighborhood Hits	270	Shared Neighborhood Hits	160
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

ANR39_HUMAN
θ value	0.00390308 (rank : 153)	NC score	0.439160 (rank : 42)
Query Neighborhood Hits	599	Target Neighborhood Hits	285	Shared Neighborhood Hits	230
SwissProt Accessions	Q53RE8, Q59FU2, Q8N5X5, Q9P0S5	Gene names	ANKRD39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ASB3_HUMAN
θ value	0.00390308 (rank : 154)	NC score	0.399704 (rank : 107)
Query Neighborhood Hits	599	Target Neighborhood Hits	316	Shared Neighborhood Hits	228
SwissProt Accessions	Q9Y575, Q9NVZ2	Gene names	ASB3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

CLPB_MOUSE
θ value	0.00390308 (rank : 155)	NC score	0.326363 (rank : 216)
Query Neighborhood Hits	599	Target Neighborhood Hits	289	Shared Neighborhood Hits	207
SwissProt Accessions	Q60649	Gene names	Clpb, Skd3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

DNMBP_HUMAN
θ value	0.00390308 (rank : 156)	NC score	0.225792 (rank : 305)
Query Neighborhood Hits	599	Target Neighborhood Hits	413	Shared Neighborhood Hits	175
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
θ value	0.00390308 (rank : 157)	NC score	0.225185 (rank : 307)
Query Neighborhood Hits	599	Target Neighborhood Hits	435	Shared Neighborhood Hits	178
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

LASP1_HUMAN
θ value	0.00390308 (rank : 158)	NC score	0.213110 (rank : 318)
Query Neighborhood Hits	599	Target Neighborhood Hits	293	Shared Neighborhood Hits	131
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	0.00390308 (rank : 159)	NC score	0.212963 (rank : 319)
Query Neighborhood Hits	599	Target Neighborhood Hits	297	Shared Neighborhood Hits	132
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

NOTC4_MOUSE
θ value	0.00390308 (rank : 160)	NC score	0.223139 (rank : 309)
Query Neighborhood Hits	599	Target Neighborhood Hits	872	Shared Neighborhood Hits	234
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

PP16A_HUMAN
θ value	0.00390308 (rank : 161)	NC score	0.384746 (rank : 135)
Query Neighborhood Hits	599	Target Neighborhood Hits	340	Shared Neighborhood Hits	235
SwissProt Accessions	Q96I34	Gene names	PPP1R16A, MYPT3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase- targeting subunit 3).

ZDH13_HUMAN
θ value	0.00390308 (rank : 162)	NC score	0.354395 (rank : 185)
Query Neighborhood Hits	599	Target Neighborhood Hits	322	Shared Neighborhood Hits	228
SwissProt Accessions	Q8IUH4, Q7Z2D3, Q86VK2, Q9NV30, Q9NV99	Gene names	ZDHHC13, HIP14L, HIP3RP
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC13 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein) (Huntingtin- interacting protein HIP3RP) (Putative NF-kappa-B-activating protein 209) (Putative MAPK-activating protein PM03).

ANKR1_HUMAN
θ value	0.00509761 (rank : 163)	NC score	0.417813 (rank : 68)
Query Neighborhood Hits	599	Target Neighborhood Hits	308	Shared Neighborhood Hits	234
SwissProt Accessions	Q15327, Q96LE7	Gene names	ANKRD1, C193, CARP, HA1A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) (Cytokine-inducible nuclear protein) (C-193).

ANR37_MOUSE
θ value	0.00509761 (rank : 164)	NC score	0.440501 (rank : 39)
Query Neighborhood Hits	599	Target Neighborhood Hits	237	Shared Neighborhood Hits	208
SwissProt Accessions	Q569N2, Q8CHS0	Gene names	Ankrd37
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37.

ANS4B_HUMAN
θ value	0.00509761 (rank : 165)	NC score	0.413346 (rank : 85)
Query Neighborhood Hits	599	Target Neighborhood Hits	289	Shared Neighborhood Hits	222
SwissProt Accessions	Q8N8V4	Gene names	ANKS4B, HARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

ASB10_MOUSE
θ value	0.00509761 (rank : 166)	NC score	0.413663 (rank : 82)
Query Neighborhood Hits	599	Target Neighborhood Hits	301	Shared Neighborhood Hits	231
SwissProt Accessions	Q91ZT7	Gene names	Asb10
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

BCAR1_HUMAN
θ value	0.00509761 (rank : 167)	NC score	0.185634 (rank : 364)
Query Neighborhood Hits	599	Target Neighborhood Hits	554	Shared Neighborhood Hits	175
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

GRAP_MOUSE
θ value	0.00509761 (rank : 168)	NC score	0.197445 (rank : 345)
Query Neighborhood Hits	599	Target Neighborhood Hits	309	Shared Neighborhood Hits	158
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

ZDH17_MOUSE
θ value	0.00509761 (rank : 169)	NC score	0.367233 (rank : 166)
Query Neighborhood Hits	599	Target Neighborhood Hits	328	Shared Neighborhood Hits	229
SwissProt Accessions	Q80TN5, Q8BJ08, Q8BYQ2, Q8BYQ6	Gene names	Zdhhc17, Hip14, Kiaa0946
Domain Architecture
Description	Palmitoyltransferase ZDHHC17 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 17) (DHHC-17) (Huntingtin-interacting protein 14).

ANR45_HUMAN
θ value	0.00665767 (rank : 170)	NC score	0.344798 (rank : 196)
Query Neighborhood Hits	599	Target Neighborhood Hits	201	Shared Neighborhood Hits	165
SwissProt Accessions	Q5TZF3, Q6ZST1	Gene names	ANKRD45
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 45.

ANS4B_MOUSE
θ value	0.00665767 (rank : 171)	NC score	0.415784 (rank : 76)
Query Neighborhood Hits	599	Target Neighborhood Hits	294	Shared Neighborhood Hits	221
SwissProt Accessions	Q8K3X6, Q9D8A5	Gene names	Anks4b, Harp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

BCL3_HUMAN
θ value	0.00665767 (rank : 172)	NC score	0.407110 (rank : 89)
Query Neighborhood Hits	599	Target Neighborhood Hits	324	Shared Neighborhood Hits	236
SwissProt Accessions	P20749	Gene names	BCL3
Domain Architecture
Description	B-cell lymphoma 3-encoded protein (Protein Bcl-3).

BCL3_MOUSE
θ value	0.00665767 (rank : 173)	NC score	0.403277 (rank : 96)
Query Neighborhood Hits	599	Target Neighborhood Hits	388	Shared Neighborhood Hits	238
SwissProt Accessions	Q9Z2F6	Gene names	Bcl3
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 3-encoded protein homolog (Protein Bcl-3).

NCF4_HUMAN
θ value	0.00665767 (rank : 174)	NC score	0.250217 (rank : 279)
Query Neighborhood Hits	599	Target Neighborhood Hits	161	Shared Neighborhood Hits	114
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

PACN3_HUMAN
θ value	0.00665767 (rank : 175)	NC score	0.222863 (rank : 310)
Query Neighborhood Hits	599	Target Neighborhood Hits	385	Shared Neighborhood Hits	151
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	0.00665767 (rank : 176)	NC score	0.225417 (rank : 306)
Query Neighborhood Hits	599	Target Neighborhood Hits	380	Shared Neighborhood Hits	160
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PP16B_HUMAN
θ value	0.00665767 (rank : 177)	NC score	0.393105 (rank : 123)
Query Neighborhood Hits	599	Target Neighborhood Hits	307	Shared Neighborhood Hits	230
SwissProt Accessions	Q96T49, O94912, Q9NQG4	Gene names	PPP1R16B, ANKRD4, KIAA0823
Domain Architecture
Description	Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein) (hTIMAP) (CAAX box protein TIMAP) (Ankyrin repeat domain protein 4).

PP16B_MOUSE
θ value	0.00665767 (rank : 178)	NC score	0.392986 (rank : 124)
Query Neighborhood Hits	599	Target Neighborhood Hits	302	Shared Neighborhood Hits	229
SwissProt Accessions	Q8VHQ3	Gene names	Ppp1r16b
Domain Architecture
Description	Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein) (CAAX box protein TIMAP).

VINEX_MOUSE
θ value	0.00665767 (rank : 179)	NC score	0.250098 (rank : 280)
Query Neighborhood Hits	599	Target Neighborhood Hits	286	Shared Neighborhood Hits	165
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ANKR2_MOUSE
θ value	0.00869519 (rank : 180)	NC score	0.413655 (rank : 83)
Query Neighborhood Hits	599	Target Neighborhood Hits	312	Shared Neighborhood Hits	232
SwissProt Accessions	Q9WV06	Gene names	Ankrd2, Arpp
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (mArpp).

BARD1_MOUSE
θ value	0.00869519 (rank : 181)	NC score	0.387139 (rank : 131)
Query Neighborhood Hits	599	Target Neighborhood Hits	411	Shared Neighborhood Hits	228
SwissProt Accessions	O70445	Gene names	Bard1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

BCAR1_MOUSE
θ value	0.00869519 (rank : 182)	NC score	0.183006 (rank : 366)
Query Neighborhood Hits	599	Target Neighborhood Hits	438	Shared Neighborhood Hits	168
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

EHMT1_HUMAN
θ value	0.00869519 (rank : 183)	NC score	0.384047 (rank : 138)
Query Neighborhood Hits	599	Target Neighborhood Hits	417	Shared Neighborhood Hits	234
SwissProt Accessions	Q9H9B1, Q8TCN7, Q96F53, Q96JF1, Q96KH4	Gene names	EHMT1, EUHMTASE1, KIAA1876
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a- like protein 1) (GLP1).

EHMT2_HUMAN
θ value	0.00869519 (rank : 184)	NC score	0.382013 (rank : 140)
Query Neighborhood Hits	599	Target Neighborhood Hits	498	Shared Neighborhood Hits	242
SwissProt Accessions	Q96KQ7, Q14349, Q6PK06, Q96MH5, Q96QD0, Q9UQL8, Q9Y331	Gene names	EHMT2, BAT8, G9A, NG36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

INVS_MOUSE
θ value	0.00869519 (rank : 185)	NC score	0.399988 (rank : 105)
Query Neighborhood Hits	599	Target Neighborhood Hits	609	Shared Neighborhood Hits	259
SwissProt Accessions	O89019, O88849	Gene names	Invs, Inv, Nphp2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning protein) (Nephrocystin-2).

STAM1_HUMAN
θ value	0.00869519 (rank : 186)	NC score	0.244630 (rank : 284)
Query Neighborhood Hits	599	Target Neighborhood Hits	271	Shared Neighborhood Hits	155
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	0.00869519 (rank : 187)	NC score	0.251554 (rank : 276)
Query Neighborhood Hits	599	Target Neighborhood Hits	273	Shared Neighborhood Hits	154
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

USH1G_HUMAN
θ value	0.00869519 (rank : 188)	NC score	0.403956 (rank : 94)
Query Neighborhood Hits	599	Target Neighborhood Hits	267	Shared Neighborhood Hits	222
SwissProt Accessions	Q495M9, Q8N251	Gene names	USH1G, SANS
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein (Scaffold protein containing ankyrin repeats and SAM domain).

USH1G_MOUSE
θ value	0.00869519 (rank : 189)	NC score	0.404326 (rank : 93)
Query Neighborhood Hits	599	Target Neighborhood Hits	271	Shared Neighborhood Hits	222
SwissProt Accessions	Q80T11, Q80UG0	Gene names	Ush1g, Sans
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein homolog (Scaffold protein containing ankyrin repeats and SAM domain) (Jackson shaker protein).

ABI2_HUMAN
θ value	0.0113563 (rank : 190)	NC score	0.248121 (rank : 282)
Query Neighborhood Hits	599	Target Neighborhood Hits	350	Shared Neighborhood Hits	176
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	0.0113563 (rank : 191)	NC score	0.238441 (rank : 291)
Query Neighborhood Hits	599	Target Neighborhood Hits	266	Shared Neighborhood Hits	149
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

AMPH_HUMAN
θ value	0.0113563 (rank : 192)	NC score	0.134634 (rank : 406)
Query Neighborhood Hits	599	Target Neighborhood Hits	455	Shared Neighborhood Hits	119
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

ANR23_HUMAN
θ value	0.0113563 (rank : 193)	NC score	0.424332 (rank : 53)
Query Neighborhood Hits	599	Target Neighborhood Hits	291	Shared Neighborhood Hits	231
SwissProt Accessions	Q86SG2, Q711K7, Q8NAJ7	Gene names	ANKRD23, DARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein) (Muscle ankyrin repeat protein 3).

FANK1_MOUSE
θ value	0.0113563 (rank : 194)	NC score	0.398898 (rank : 112)
Query Neighborhood Hits	599	Target Neighborhood Hits	325	Shared Neighborhood Hits	230
SwissProt Accessions	Q9DAM9, Q9CUA7	Gene names	Fank1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains 1 protein (Germ cell- specific gene 1 protein) (GSG1).

INVS_HUMAN
θ value	0.0113563 (rank : 195)	NC score	0.400488 (rank : 103)
Query Neighborhood Hits	599	Target Neighborhood Hits	455	Shared Neighborhood Hits	247
SwissProt Accessions	Q9Y283, Q5W0T6, Q8IVX8, Q9BRB9, Q9Y488, Q9Y498	Gene names	INVS, INV, NPHP2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning homolog) (Nephrocystin-2).

JIP2_HUMAN
θ value	0.0113563 (rank : 196)	NC score	0.114954 (rank : 431)
Query Neighborhood Hits	599	Target Neighborhood Hits	288	Shared Neighborhood Hits	94
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JIP2_MOUSE
θ value	0.0113563 (rank : 197)	NC score	0.103465 (rank : 444)
Query Neighborhood Hits	599	Target Neighborhood Hits	144	Shared Neighborhood Hits	64
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

PPIP1_HUMAN
θ value	0.0113563 (rank : 198)	NC score	0.221942 (rank : 312)
Query Neighborhood Hits	599	Target Neighborhood Hits	389	Shared Neighborhood Hits	169
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

RGS3_MOUSE
θ value	0.0113563 (rank : 199)	NC score	0.068621 (rank : 510)
Query Neighborhood Hits	599	Target Neighborhood Hits	1621	Shared Neighborhood Hits	150
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

TNKS1_HUMAN
θ value	0.0113563 (rank : 200)	NC score	0.414486 (rank : 79)
Query Neighborhood Hits	599	Target Neighborhood Hits	477	Shared Neighborhood Hits	261
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

ANR26_MOUSE
θ value	0.0148317 (rank : 201)	NC score	0.242780 (rank : 286)
Query Neighborhood Hits	599	Target Neighborhood Hits	1554	Shared Neighborhood Hits	303
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

ANRA2_HUMAN
θ value	0.0148317 (rank : 202)	NC score	0.398724 (rank : 113)
Query Neighborhood Hits	599	Target Neighborhood Hits	288	Shared Neighborhood Hits	225
SwissProt Accessions	Q9H9E1	Gene names	ANKRA2, ANKRA
Domain Architecture
Description	Ankyrin repeat family A protein 2 (RFXANK-like 2).

ARHG4_HUMAN
θ value	0.0148317 (rank : 203)	NC score	0.175360 (rank : 376)
Query Neighborhood Hits	599	Target Neighborhood Hits	242	Shared Neighborhood Hits	138
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

CRK_HUMAN
θ value	0.0148317 (rank : 204)	NC score	0.196672 (rank : 346)
Query Neighborhood Hits	599	Target Neighborhood Hits	308	Shared Neighborhood Hits	148
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	0.0148317 (rank : 205)	NC score	0.199097 (rank : 341)
Query Neighborhood Hits	599	Target Neighborhood Hits	314	Shared Neighborhood Hits	146
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CTTB2_HUMAN
θ value	0.0148317 (rank : 206)	NC score	0.369678 (rank : 162)
Query Neighborhood Hits	599	Target Neighborhood Hits	1061	Shared Neighborhood Hits	302
SwissProt Accessions	Q8WZ74, O43389, Q7LG11, Q9C0A5	Gene names	CTTNBP2, C7orf8, CORTBP2, KIAA1758
Domain Architecture	No domain graphic available
Description	Cortactin-binding protein 2 (CortBP2).

EPAS1_MOUSE
θ value	0.0148317 (rank : 207)	NC score	0.021747 (rank : 736)
Query Neighborhood Hits	599	Target Neighborhood Hits	94	Shared Neighborhood Hits	12
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

MAGE1_HUMAN
θ value	0.0148317 (rank : 208)	NC score	0.059451 (rank : 567)
Query Neighborhood Hits	599	Target Neighborhood Hits	1389	Shared Neighborhood Hits	126
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MKL1_MOUSE
θ value	0.0148317 (rank : 209)	NC score	0.058181 (rank : 574)
Query Neighborhood Hits	599	Target Neighborhood Hits	667	Shared Neighborhood Hits	74
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

ANR18_HUMAN
θ value	0.0193708 (rank : 210)	NC score	0.312761 (rank : 223)
Query Neighborhood Hits	599	Target Neighborhood Hits	1106	Shared Neighborhood Hits	284
SwissProt Accessions	Q8IVF6, Q7Z468	Gene names	ANKRD18A, KIAA2015
Domain Architecture
Description	Ankyrin repeat domain-containing protein 18A.

GSCR1_HUMAN
θ value	0.0193708 (rank : 211)	NC score	0.091432 (rank : 463)
Query Neighborhood Hits	599	Target Neighborhood Hits	674	Shared Neighborhood Hits	112
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

NCOA6_MOUSE
θ value	0.0193708 (rank : 212)	NC score	0.078808 (rank : 490)
Query Neighborhood Hits	599	Target Neighborhood Hits	1076	Shared Neighborhood Hits	120
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

RIPK4_HUMAN
θ value	0.0193708 (rank : 213)	NC score	0.251240 (rank : 277)
Query Neighborhood Hits	599	Target Neighborhood Hits	1094	Shared Neighborhood Hits	249
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

ANKR2_HUMAN
θ value	0.0252991 (rank : 214)	NC score	0.416088 (rank : 74)
Query Neighborhood Hits	599	Target Neighborhood Hits	321	Shared Neighborhood Hits	235
SwissProt Accessions	Q9GZV1, Q5T456, Q8WUD7	Gene names	ANKRD2, ARPP
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp).

ANKS1_MOUSE
θ value	0.0252991 (rank : 215)	NC score	0.372795 (rank : 156)
Query Neighborhood Hits	599	Target Neighborhood Hits	453	Shared Neighborhood Hits	242
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

ANR23_MOUSE
θ value	0.0252991 (rank : 216)	NC score	0.420165 (rank : 61)
Query Neighborhood Hits	599	Target Neighborhood Hits	296	Shared Neighborhood Hits	229
SwissProt Accessions	Q812A3	Gene names	Ankrd23, Darp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein).

ARHG9_HUMAN
θ value	0.0252991 (rank : 217)	NC score	0.168151 (rank : 380)
Query Neighborhood Hits	599	Target Neighborhood Hits	235	Shared Neighborhood Hits	135
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	0.0252991 (rank : 218)	NC score	0.167836 (rank : 382)
Query Neighborhood Hits	599	Target Neighborhood Hits	234	Shared Neighborhood Hits	134
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

EHMT2_MOUSE
θ value	0.0252991 (rank : 219)	NC score	0.373234 (rank : 153)
Query Neighborhood Hits	599	Target Neighborhood Hits	750	Shared Neighborhood Hits	266
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

GRAP_HUMAN
θ value	0.0252991 (rank : 220)	NC score	0.193188 (rank : 354)
Query Neighborhood Hits	599	Target Neighborhood Hits	307	Shared Neighborhood Hits	159
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

OSBL3_MOUSE
θ value	0.0252991 (rank : 221)	NC score	0.099468 (rank : 453)
Query Neighborhood Hits	599	Target Neighborhood Hits	86	Shared Neighborhood Hits	27
SwissProt Accessions	Q9DBS9	Gene names	Osbpl3, Orp3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

PP16A_MOUSE
θ value	0.0252991 (rank : 222)	NC score	0.397252 (rank : 115)
Query Neighborhood Hits	599	Target Neighborhood Hits	318	Shared Neighborhood Hits	231
SwissProt Accessions	Q923M0, Q4V9Z1	Gene names	Ppp1r16a, Mypt3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase targeting subunit 3).

RAI14_MOUSE
θ value	0.0252991 (rank : 223)	NC score	0.313032 (rank : 222)
Query Neighborhood Hits	599	Target Neighborhood Hits	1505	Shared Neighborhood Hits	304
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

TNKS2_HUMAN
θ value	0.0252991 (rank : 224)	NC score	0.406885 (rank : 90)
Query Neighborhood Hits	599	Target Neighborhood Hits	361	Shared Neighborhood Hits	236
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

ACBD6_HUMAN
θ value	0.0330416 (rank : 225)	NC score	0.384101 (rank : 137)
Query Neighborhood Hits	599	Target Neighborhood Hits	304	Shared Neighborhood Hits	227
SwissProt Accessions	Q9BR61	Gene names	ACBD6
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 6.

ANKK1_MOUSE
θ value	0.0330416 (rank : 226)	NC score	0.250275 (rank : 278)
Query Neighborhood Hits	599	Target Neighborhood Hits	1072	Shared Neighborhood Hits	249
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

ANRA2_MOUSE
θ value	0.0330416 (rank : 227)	NC score	0.397624 (rank : 114)
Query Neighborhood Hits	599	Target Neighborhood Hits	287	Shared Neighborhood Hits	225
SwissProt Accessions	Q99PE2	Gene names	Ankra2, Ankra
Domain Architecture
Description	Ankyrin repeat family A protein 2 (RFXANK-like 2).

ASB11_MOUSE
θ value	0.0330416 (rank : 228)	NC score	0.376493 (rank : 144)
Query Neighborhood Hits	599	Target Neighborhood Hits	271	Shared Neighborhood Hits	221
SwissProt Accessions	Q9CQ31, Q3UJ13, Q9D0V1	Gene names	Asb11
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 11 (ASB-11).

ASB15_MOUSE
θ value	0.0330416 (rank : 229)	NC score	0.365536 (rank : 171)
Query Neighborhood Hits	599	Target Neighborhood Hits	292	Shared Neighborhood Hits	224
SwissProt Accessions	Q8VHS6	Gene names	Asb15
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 15 (ASB-15).

ASZ1_MOUSE
θ value	0.0330416 (rank : 230)	NC score	0.376273 (rank : 147)
Query Neighborhood Hits	599	Target Neighborhood Hits	319	Shared Neighborhood Hits	230
SwissProt Accessions	Q8VD46, Q9JKQ7	Gene names	Asz1, Gasz
Domain Architecture
Description	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).

GCC2_MOUSE
θ value	0.0330416 (rank : 231)	NC score	0.045808 (rank : 636)
Query Neighborhood Hits	599	Target Neighborhood Hits	1619	Shared Neighborhood Hits	112
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

GRAP2_HUMAN
θ value	0.0330416 (rank : 232)	NC score	0.206214 (rank : 327)
Query Neighborhood Hits	599	Target Neighborhood Hits	304	Shared Neighborhood Hits	153
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

MIB2_MOUSE
θ value	0.0330416 (rank : 233)	NC score	0.385204 (rank : 134)
Query Neighborhood Hits	599	Target Neighborhood Hits	409	Shared Neighborhood Hits	230
SwissProt Accessions	Q8R516, Q52QU8, Q6PEF6, Q8C1N7, Q8VIB4	Gene names	Mib2, Skd
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) (Dystrophin-like protein) (Dyslike).

NCF4_MOUSE
θ value	0.0330416 (rank : 234)	NC score	0.243910 (rank : 285)
Query Neighborhood Hits	599	Target Neighborhood Hits	177	Shared Neighborhood Hits	123
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NEBU_HUMAN
θ value	0.0330416 (rank : 235)	NC score	0.160560 (rank : 386)
Query Neighborhood Hits	599	Target Neighborhood Hits	420	Shared Neighborhood Hits	148
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

VAV_HUMAN
θ value	0.0330416 (rank : 236)	NC score	0.165661 (rank : 383)
Query Neighborhood Hits	599	Target Neighborhood Hits	452	Shared Neighborhood Hits	158
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ACBD6_MOUSE
θ value	0.0431538 (rank : 237)	NC score	0.385579 (rank : 133)
Query Neighborhood Hits	599	Target Neighborhood Hits	305	Shared Neighborhood Hits	229
SwissProt Accessions	Q9D061, Q3TMN7, Q9DCU4	Gene names	Acbd6
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 6.

CRKL_HUMAN
θ value	0.0431538 (rank : 238)	NC score	0.203377 (rank : 329)
Query Neighborhood Hits	599	Target Neighborhood Hits	313	Shared Neighborhood Hits	149
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

GABP2_HUMAN
θ value	0.0431538 (rank : 239)	NC score	0.417118 (rank : 70)
Query Neighborhood Hits	599	Target Neighborhood Hits	454	Shared Neighborhood Hits	241
SwissProt Accessions	Q06547, Q06545, Q12940, Q12941, Q12942, Q8IYD0	Gene names	GABPB2, E4TF1B, GABPB, GABPB1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1) (Transcription factor E4TF1-53) (Transcription factor E4TF1-47) (Nuclear respiratory factor 2).

GABP2_MOUSE
θ value	0.0431538 (rank : 240)	NC score	0.417918 (rank : 67)
Query Neighborhood Hits	599	Target Neighborhood Hits	429	Shared Neighborhood Hits	239
SwissProt Accessions	Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2	Gene names	Gabpb2, Gabpb, Gabpb1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1).

GRAP2_MOUSE
θ value	0.0431538 (rank : 241)	NC score	0.208106 (rank : 326)
Query Neighborhood Hits	599	Target Neighborhood Hits	297	Shared Neighborhood Hits	152
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

NEBL_HUMAN
θ value	0.0431538 (rank : 242)	NC score	0.187937 (rank : 361)
Query Neighborhood Hits	599	Target Neighborhood Hits	457	Shared Neighborhood Hits	159
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

POTE8_HUMAN
θ value	0.0431538 (rank : 243)	NC score	0.373015 (rank : 155)
Query Neighborhood Hits	599	Target Neighborhood Hits	337	Shared Neighborhood Hits	229
SwissProt Accessions	Q6S8J7, Q6S8J6	Gene names	POTE8
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 8.

RAI14_HUMAN
θ value	0.0431538 (rank : 244)	NC score	0.327042 (rank : 213)
Query Neighborhood Hits	599	Target Neighborhood Hits	1367	Shared Neighborhood Hits	296
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

RFXK_HUMAN
θ value	0.0431538 (rank : 245)	NC score	0.375563 (rank : 148)
Query Neighborhood Hits	599	Target Neighborhood Hits	282	Shared Neighborhood Hits	225
SwissProt Accessions	O14593, O95839	Gene names	RFXANK, ANKRA1, RFXB
Domain Architecture
Description	DNA-binding protein RFXANK (Regulatory factor X subunit B) (RFX-B) (Ankyrin repeat family A protein 1).

SNCAP_HUMAN
θ value	0.0431538 (rank : 246)	NC score	0.366989 (rank : 167)
Query Neighborhood Hits	599	Target Neighborhood Hits	313	Shared Neighborhood Hits	217
SwissProt Accessions	Q9Y6H5	Gene names	SNCAIP
Domain Architecture
Description	Synphilin-1 (Alpha-synuclein-interacting protein).

ANKK1_HUMAN
θ value	0.0563607 (rank : 247)	NC score	0.254782 (rank : 270)
Query Neighborhood Hits	599	Target Neighborhood Hits	1075	Shared Neighborhood Hits	249
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

ANKR5_MOUSE
θ value	0.0563607 (rank : 248)	NC score	0.396317 (rank : 116)
Query Neighborhood Hits	599	Target Neighborhood Hits	298	Shared Neighborhood Hits	229
SwissProt Accessions	Q9D2J7	Gene names	Ankrd5
Domain Architecture
Description	Ankyrin repeat domain-containing protein 5.

ANR49_HUMAN
θ value	0.0563607 (rank : 249)	NC score	0.401800 (rank : 98)
Query Neighborhood Hits	599	Target Neighborhood Hits	282	Shared Neighborhood Hits	228
SwissProt Accessions	Q8WVL7, Q8NDF2, Q96JE5, Q9NXK7	Gene names	ANKRD49, FGIF
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor).

ASB15_HUMAN
θ value	0.0563607 (rank : 250)	NC score	0.374155 (rank : 150)
Query Neighborhood Hits	599	Target Neighborhood Hits	305	Shared Neighborhood Hits	228
SwissProt Accessions	Q8WXK1	Gene names	ASB15
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 15 (ASB-15).

ASB4_MOUSE
θ value	0.0563607 (rank : 251)	NC score	0.375142 (rank : 149)
Query Neighborhood Hits	599	Target Neighborhood Hits	265	Shared Neighborhood Hits	222
SwissProt Accessions	Q9WV71	Gene names	Asb4
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 4 (ASB-4).

DOCK1_HUMAN
θ value	0.0563607 (rank : 252)	NC score	0.090054 (rank : 466)
Query Neighborhood Hits	599	Target Neighborhood Hits	191	Shared Neighborhood Hits	101
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

FANK1_HUMAN
θ value	0.0563607 (rank : 253)	NC score	0.396171 (rank : 117)
Query Neighborhood Hits	599	Target Neighborhood Hits	326	Shared Neighborhood Hits	231
SwissProt Accessions	Q8TC84, Q6UXY9, Q6X7T6	Gene names	FANK1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains protein 1.

NOTC2_HUMAN
θ value	0.0563607 (rank : 254)	NC score	0.193409 (rank : 352)
Query Neighborhood Hits	599	Target Neighborhood Hits	1113	Shared Neighborhood Hits	260
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

NOTC2_MOUSE
θ value	0.0563607 (rank : 255)	NC score	0.190398 (rank : 357)
Query Neighborhood Hits	599	Target Neighborhood Hits	1069	Shared Neighborhood Hits	249
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

PPIP1_MOUSE
θ value	0.0563607 (rank : 256)	NC score	0.220980 (rank : 313)
Query Neighborhood Hits	599	Target Neighborhood Hits	377	Shared Neighborhood Hits	173
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

RFIP3_HUMAN
θ value	0.0563607 (rank : 257)	NC score	0.045943 (rank : 635)
Query Neighborhood Hits	599	Target Neighborhood Hits	1055	Shared Neighborhood Hits	100
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

RHG09_HUMAN
θ value	0.0563607 (rank : 258)	NC score	0.090060 (rank : 465)
Query Neighborhood Hits	599	Target Neighborhood Hits	186	Shared Neighborhood Hits	47
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

AMPH_MOUSE
θ value	0.0736092 (rank : 259)	NC score	0.122807 (rank : 415)
Query Neighborhood Hits	599	Target Neighborhood Hits	291	Shared Neighborhood Hits	105
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

AN13C_HUMAN
θ value	0.0736092 (rank : 260)	NC score	0.270100 (rank : 252)
Query Neighborhood Hits	599	Target Neighborhood Hits	241	Shared Neighborhood Hits	205
SwissProt Accessions	Q8N6S4, Q5VYH4, Q5VYH5, Q6PJE4, Q9H0N9	Gene names	ANKRD13C
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13C.

AN13C_MOUSE
θ value	0.0736092 (rank : 261)	NC score	0.264911 (rank : 260)
Query Neighborhood Hits	599	Target Neighborhood Hits	242	Shared Neighborhood Hits	201
SwissProt Accessions	Q3UX43, Q6P1G4	Gene names	Ankrd13c
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13C.

AN30A_HUMAN
θ value	0.0736092 (rank : 262)	NC score	0.277588 (rank : 241)
Query Neighborhood Hits	599	Target Neighborhood Hits	1119	Shared Neighborhood Hits	280
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

ANR19_HUMAN
θ value	0.0736092 (rank : 263)	NC score	0.376533 (rank : 143)
Query Neighborhood Hits	599	Target Neighborhood Hits	276	Shared Neighborhood Hits	222
SwissProt Accessions	Q9H560	Gene names	ANKRD19
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 19.

CEL_HUMAN
θ value	0.0736092 (rank : 264)	NC score	0.038201 (rank : 674)
Query Neighborhood Hits	599	Target Neighborhood Hits	896	Shared Neighborhood Hits	82
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

CRKL_MOUSE
θ value	0.0736092 (rank : 265)	NC score	0.200020 (rank : 336)
Query Neighborhood Hits	599	Target Neighborhood Hits	307	Shared Neighborhood Hits	146
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

IASPP_MOUSE
θ value	0.0736092 (rank : 266)	NC score	0.361051 (rank : 176)
Query Neighborhood Hits	599	Target Neighborhood Hits	1024	Shared Neighborhood Hits	379
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IWS1_HUMAN
θ value	0.0736092 (rank : 267)	NC score	0.038329 (rank : 673)
Query Neighborhood Hits	599	Target Neighborhood Hits	1241	Shared Neighborhood Hits	100
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

K1802_MOUSE
θ value	0.0736092 (rank : 268)	NC score	0.039643 (rank : 666)
Query Neighborhood Hits	599	Target Neighborhood Hits	1596	Shared Neighborhood Hits	121
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MUC1_HUMAN
θ value	0.0736092 (rank : 269)	NC score	0.048211 (rank : 631)
Query Neighborhood Hits	599	Target Neighborhood Hits	975	Shared Neighborhood Hits	99
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

NUD12_HUMAN
θ value	0.0736092 (rank : 270)	NC score	0.270823 (rank : 250)
Query Neighborhood Hits	599	Target Neighborhood Hits	222	Shared Neighborhood Hits	173
SwissProt Accessions	Q9BQG2, Q8TAL7	Gene names	NUDT12
Domain Architecture	No domain graphic available
Description	Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12).

SEPT9_HUMAN
θ value	0.0736092 (rank : 271)	NC score	0.034643 (rank : 695)
Query Neighborhood Hits	599	Target Neighborhood Hits	706	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

VAV_MOUSE
θ value	0.0736092 (rank : 272)	NC score	0.165319 (rank : 384)
Query Neighborhood Hits	599	Target Neighborhood Hits	430	Shared Neighborhood Hits	158
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ANKR5_HUMAN
θ value	0.0961366 (rank : 273)	NC score	0.394294 (rank : 120)
Query Neighborhood Hits	599	Target Neighborhood Hits	297	Shared Neighborhood Hits	228
SwissProt Accessions	Q9NU02, Q9H6Y9	Gene names	ANKRD5
Domain Architecture
Description	Ankyrin repeat domain-containing protein 5.

ANKR9_MOUSE
θ value	0.0961366 (rank : 274)	NC score	0.194930 (rank : 349)
Query Neighborhood Hits	599	Target Neighborhood Hits	120	Shared Neighborhood Hits	110
SwissProt Accessions	Q8BH83, Q3TA09, Q8BHR3	Gene names	Ankrd9
Domain Architecture
Description	Ankyrin repeat domain-containing protein 9.

ANR41_HUMAN
θ value	0.0961366 (rank : 275)	NC score	0.406636 (rank : 91)
Query Neighborhood Hits	599	Target Neighborhood Hits	332	Shared Neighborhood Hits	219
SwissProt Accessions	Q8NAG6, Q8N8J8	Gene names	ANKRD41
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 41.

ASB5_HUMAN
θ value	0.0961366 (rank : 276)	NC score	0.366826 (rank : 168)
Query Neighborhood Hits	599	Target Neighborhood Hits	283	Shared Neighborhood Hits	224
SwissProt Accessions	Q8WWX0	Gene names	ASB5
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 5 (ASB-5).

GABP3_MOUSE
θ value	0.0961366 (rank : 277)	NC score	0.420546 (rank : 60)
Query Neighborhood Hits	599	Target Neighborhood Hits	330	Shared Neighborhood Hits	233
SwissProt Accessions	P81069	Gene names	Gabpb2
Domain Architecture	No domain graphic available
Description	GA-binding protein beta-2-1 chain (GABP subunit beta-2-1) (GABPB2-1).

IASPP_HUMAN
θ value	0.0961366 (rank : 278)	NC score	0.387923 (rank : 129)
Query Neighborhood Hits	599	Target Neighborhood Hits	688	Shared Neighborhood Hits	382
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

MIB2_HUMAN
θ value	0.0961366 (rank : 279)	NC score	0.387049 (rank : 132)
Query Neighborhood Hits	599	Target Neighborhood Hits	438	Shared Neighborhood Hits	232
SwissProt Accessions	Q96AX9, Q7Z437, Q8IY62, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1	Gene names	MIB2, SKD, ZZANK1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N).

NOTC1_MOUSE
θ value	0.0961366 (rank : 280)	NC score	0.157314 (rank : 389)
Query Neighborhood Hits	599	Target Neighborhood Hits	916	Shared Neighborhood Hits	230
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

OSBP2_MOUSE
θ value	0.0961366 (rank : 281)	NC score	0.083483 (rank : 480)
Query Neighborhood Hits	599	Target Neighborhood Hits	150	Shared Neighborhood Hits	39
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

STAC_HUMAN
θ value	0.0961366 (rank : 282)	NC score	0.218866 (rank : 315)
Query Neighborhood Hits	599	Target Neighborhood Hits	276	Shared Neighborhood Hits	146
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

TRPA1_HUMAN
θ value	0.0961366 (rank : 283)	NC score	0.383842 (rank : 139)
Query Neighborhood Hits	599	Target Neighborhood Hits	339	Shared Neighborhood Hits	231
SwissProt Accessions	O75762	Gene names	TRPA1, ANKTM1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation sensitive-protein p120).

ANKS3_MOUSE
θ value	0.125558 (rank : 284)	NC score	0.380413 (rank : 141)
Query Neighborhood Hits	599	Target Neighborhood Hits	355	Shared Neighborhood Hits	229
SwissProt Accessions	Q9CZK6, Q6ZPF6, Q80X46	Gene names	Anks3, Kiaa1977
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 3.

ANR49_MOUSE
θ value	0.125558 (rank : 285)	NC score	0.394469 (rank : 119)
Query Neighborhood Hits	599	Target Neighborhood Hits	285	Shared Neighborhood Hits	227
SwissProt Accessions	Q8VE42, Q9Z2S1	Gene names	Ankrd49, Fgif, Gbif
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor) (Fetal globin-increasing factor).

ASB11_HUMAN
θ value	0.125558 (rank : 286)	NC score	0.370099 (rank : 160)
Query Neighborhood Hits	599	Target Neighborhood Hits	271	Shared Neighborhood Hits	221
SwissProt Accessions	Q8WXH4, Q3SYC4	Gene names	ASB11
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 11 (ASB-11).

ASB13_HUMAN
θ value	0.125558 (rank : 287)	NC score	0.399543 (rank : 108)
Query Neighborhood Hits	599	Target Neighborhood Hits	293	Shared Neighborhood Hits	226
SwissProt Accessions	Q8WXK3, Q96EP7, Q9H8Z1	Gene names	ASB13
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 13 (ASB-13).

ASB13_MOUSE
θ value	0.125558 (rank : 288)	NC score	0.400001 (rank : 104)
Query Neighborhood Hits	599	Target Neighborhood Hits	293	Shared Neighborhood Hits	227
SwissProt Accessions	Q8VBX0	Gene names	Asb13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 13 (ASB-13).

ASPP1_MOUSE
θ value	0.125558 (rank : 289)	NC score	0.357922 (rank : 182)
Query Neighborhood Hits	599	Target Neighborhood Hits	1244	Shared Neighborhood Hits	418
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASZ1_HUMAN
θ value	0.125558 (rank : 290)	NC score	0.368213 (rank : 164)
Query Neighborhood Hits	599	Target Neighborhood Hits	341	Shared Neighborhood Hits	234
SwissProt Accessions	Q8WWH4	Gene names	ASZ1, GASZ
Domain Architecture
Description	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).

BTK_HUMAN
θ value	0.125558 (rank : 291)	NC score	0.045606 (rank : 638)
Query Neighborhood Hits	599	Target Neighborhood Hits	1026	Shared Neighborhood Hits	154
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

DGKI_HUMAN
θ value	0.125558 (rank : 292)	NC score	0.193382 (rank : 353)
Query Neighborhood Hits	599	Target Neighborhood Hits	609	Shared Neighborhood Hits	191
SwissProt Accessions	O75912, Q9NZ49	Gene names	DGKI
Domain Architecture
Description	Diacylglycerol kinase iota (EC 2.7.1.107) (Diglyceride kinase iota) (DGK-iota) (DAG kinase iota).

IKBE_HUMAN
θ value	0.125558 (rank : 293)	NC score	0.384135 (rank : 136)
Query Neighborhood Hits	599	Target Neighborhood Hits	288	Shared Neighborhood Hits	225
SwissProt Accessions	O00221	Gene names	NFKBIE, IKBE
Domain Architecture
Description	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKBE).

NACAM_MOUSE
θ value	0.125558 (rank : 294)	NC score	0.081840 (rank : 483)
Query Neighborhood Hits	599	Target Neighborhood Hits	1866	Shared Neighborhood Hits	167
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

POT15_HUMAN
θ value	0.125558 (rank : 295)	NC score	0.351601 (rank : 188)
Query Neighborhood Hits	599	Target Neighborhood Hits	893	Shared Neighborhood Hits	275
SwissProt Accessions	Q6S5H4, Q6NXN7, Q6S5H7	Gene names	POTE15
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 15.

PRRT3_HUMAN
θ value	0.125558 (rank : 296)	NC score	0.062658 (rank : 541)
Query Neighborhood Hits	599	Target Neighborhood Hits	998	Shared Neighborhood Hits	89
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

RIMB1_MOUSE
θ value	0.125558 (rank : 297)	NC score	0.097164 (rank : 457)
Query Neighborhood Hits	599	Target Neighborhood Hits	1376	Shared Neighborhood Hits	210
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

STAC3_HUMAN
θ value	0.125558 (rank : 298)	NC score	0.198803 (rank : 343)
Query Neighborhood Hits	599	Target Neighborhood Hits	228	Shared Neighborhood Hits	121
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	0.125558 (rank : 299)	NC score	0.199045 (rank : 342)
Query Neighborhood Hits	599	Target Neighborhood Hits	232	Shared Neighborhood Hits	121
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_MOUSE
θ value	0.125558 (rank : 300)	NC score	0.210505 (rank : 323)
Query Neighborhood Hits	599	Target Neighborhood Hits	268	Shared Neighborhood Hits	140
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

TM108_MOUSE
θ value	0.125558 (rank : 301)	NC score	0.054966 (rank : 594)
Query Neighborhood Hits	599	Target Neighborhood Hits	336	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BHE4, Q80WR9	Gene names	Tmem108
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

TULP4_HUMAN
θ value	0.125558 (rank : 302)	NC score	0.036602 (rank : 686)
Query Neighborhood Hits	599	Target Neighborhood Hits	426	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NRJ4, Q9HD22, Q9P2F0	Gene names	TULP4, KIAA1397, TUSP
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

ANR21_HUMAN
θ value	0.163984 (rank : 303)	NC score	0.352487 (rank : 187)
Query Neighborhood Hits	599	Target Neighborhood Hits	864	Shared Neighborhood Hits	266
SwissProt Accessions	Q86YR6	Gene names	ANKRD21, POTE
Domain Architecture
Description	Ankyrin repeat domain-containing protein 21 (Protein POTE) (Prostate, ovary, testis-expressed protein).

ANR29_HUMAN
θ value	0.163984 (rank : 304)	NC score	0.401509 (rank : 100)
Query Neighborhood Hits	599	Target Neighborhood Hits	294	Shared Neighborhood Hits	227
SwissProt Accessions	Q8N6D5, Q6ZWE8, Q96LU9	Gene names	ANKRD29
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 29.

ANR50_HUMAN
θ value	0.163984 (rank : 305)	NC score	0.403816 (rank : 95)
Query Neighborhood Hits	599	Target Neighborhood Hits	361	Shared Neighborhood Hits	229
SwissProt Accessions	Q9ULJ7, Q6N064, Q6ZSE6	Gene names	ANKRD50, KIAA1223
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 50.

CCD41_MOUSE
θ value	0.163984 (rank : 306)	NC score	0.044570 (rank : 640)
Query Neighborhood Hits	599	Target Neighborhood Hits	1399	Shared Neighborhood Hits	107
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

DBNL_MOUSE
θ value	0.163984 (rank : 307)	NC score	0.204828 (rank : 328)
Query Neighborhood Hits	599	Target Neighborhood Hits	306	Shared Neighborhood Hits	137
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

EPS8_MOUSE
θ value	0.163984 (rank : 308)	NC score	0.105706 (rank : 440)
Query Neighborhood Hits	599	Target Neighborhood Hits	157	Shared Neighborhood Hits	101
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L3_HUMAN
θ value	0.163984 (rank : 309)	NC score	0.117319 (rank : 428)
Query Neighborhood Hits	599	Target Neighborhood Hits	206	Shared Neighborhood Hits	93
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

NCK1_HUMAN
θ value	0.163984 (rank : 310)	NC score	0.188114 (rank : 360)
Query Neighborhood Hits	599	Target Neighborhood Hits	312	Shared Neighborhood Hits	151
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NFKB1_HUMAN
θ value	0.163984 (rank : 311)	NC score	0.329094 (rank : 210)
Query Neighborhood Hits	599	Target Neighborhood Hits	306	Shared Neighborhood Hits	228
SwissProt Accessions	P19838, Q68D84, Q86V43, Q8N4X7, Q9NZC0	Gene names	NFKB1
Domain Architecture
Description	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) [Contains: Nuclear factor NF-kappa-B p50 subunit].

NFKB1_MOUSE
θ value	0.163984 (rank : 312)	NC score	0.329030 (rank : 211)
Query Neighborhood Hits	599	Target Neighborhood Hits	300	Shared Neighborhood Hits	223
SwissProt Accessions	P25799, Q3TZE8, Q3V2V6, Q6TDG8, Q75ZL1, Q80Y21, Q8C712	Gene names	Nfkb1
Domain Architecture
Description	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) (NF-kappa-B1 p84/NF-kappa-B1 p98) [Contains: Nuclear factor NF- kappa-B p50 subunit].

NOTC1_HUMAN
θ value	0.163984 (rank : 313)	NC score	0.188273 (rank : 359)
Query Neighborhood Hits	599	Target Neighborhood Hits	906	Shared Neighborhood Hits	239
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

RFXK_MOUSE
θ value	0.163984 (rank : 314)	NC score	0.368191 (rank : 165)
Query Neighborhood Hits	599	Target Neighborhood Hits	273	Shared Neighborhood Hits	227
SwissProt Accessions	Q9Z205	Gene names	Rfxank, Rfxb, Tvl1
Domain Architecture
Description	DNA-binding protein RFXANK (Regulatory factor X subunit B) (RFX-B) (Regulatory factor X-associated ankyrin-containing protein) (Ankyrin repeat-containing adapter protein Tvl-1).

ABI1_HUMAN
θ value	0.21417 (rank : 315)	NC score	0.226895 (rank : 303)
Query Neighborhood Hits	599	Target Neighborhood Hits	257	Shared Neighborhood Hits	157
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	0.21417 (rank : 316)	NC score	0.228600 (rank : 301)
Query Neighborhood Hits	599	Target Neighborhood Hits	246	Shared Neighborhood Hits	150
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ANR12_HUMAN
θ value	0.21417 (rank : 317)	NC score	0.339660 (rank : 202)
Query Neighborhood Hits	599	Target Neighborhood Hits	1081	Shared Neighborhood Hits	280
SwissProt Accessions	Q6UB98, O94951, Q658K1, Q6QMF7, Q9H231, Q9H784	Gene names	ANKRD12, ANCO2, KIAA0874
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein).

ARHG4_MOUSE
θ value	0.21417 (rank : 318)	NC score	0.147817 (rank : 392)
Query Neighborhood Hits	599	Target Neighborhood Hits	185	Shared Neighborhood Hits	104
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

CUTL1_HUMAN
θ value	0.21417 (rank : 319)	NC score	0.036881 (rank : 683)
Query Neighborhood Hits	599	Target Neighborhood Hits	1574	Shared Neighborhood Hits	134
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

DBNL_HUMAN
θ value	0.21417 (rank : 320)	NC score	0.201977 (rank : 330)
Query Neighborhood Hits	599	Target Neighborhood Hits	244	Shared Neighborhood Hits	129
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

GRB2_HUMAN
θ value	0.21417 (rank : 321)	NC score	0.199764 (rank : 338)
Query Neighborhood Hits	599	Target Neighborhood Hits	310	Shared Neighborhood Hits	155
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	0.21417 (rank : 322)	NC score	0.199097 (rank : 340)
Query Neighborhood Hits	599	Target Neighborhood Hits	312	Shared Neighborhood Hits	155
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

HCLS1_HUMAN
θ value	0.21417 (rank : 323)	NC score	0.234213 (rank : 297)
Query Neighborhood Hits	599	Target Neighborhood Hits	358	Shared Neighborhood Hits	161
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

ICA69_HUMAN
θ value	0.21417 (rank : 324)	NC score	0.025128 (rank : 729)
Query Neighborhood Hits	599	Target Neighborhood Hits	35	Shared Neighborhood Hits	5
SwissProt Accessions	Q05084, P78506, Q13824	Gene names	ICA1
Domain Architecture
Description	Islet cell autoantigen 1 (69 kDa islet cell autoantigen) (ICA69) (p69) (Islet cell autoantigen p69) (ICAp69).

MYO10_HUMAN
θ value	0.21417 (rank : 325)	NC score	0.063634 (rank : 536)
Query Neighborhood Hits	599	Target Neighborhood Hits	920	Shared Neighborhood Hits	108
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

OSBP2_HUMAN
θ value	0.21417 (rank : 326)	NC score	0.085670 (rank : 475)
Query Neighborhood Hits	599	Target Neighborhood Hits	154	Shared Neighborhood Hits	39
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

PELP1_MOUSE
θ value	0.21417 (rank : 327)	NC score	0.055226 (rank : 592)
Query Neighborhood Hits	599	Target Neighborhood Hits	709	Shared Neighborhood Hits	100
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

PLCG1_MOUSE
θ value	0.21417 (rank : 328)	NC score	0.138812 (rank : 399)
Query Neighborhood Hits	599	Target Neighborhood Hits	314	Shared Neighborhood Hits	133
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

RHG26_HUMAN
θ value	0.21417 (rank : 329)	NC score	0.255855 (rank : 269)
Query Neighborhood Hits	599	Target Neighborhood Hits	281	Shared Neighborhood Hits	132
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RIMB1_HUMAN
θ value	0.21417 (rank : 330)	NC score	0.109582 (rank : 436)
Query Neighborhood Hits	599	Target Neighborhood Hits	1479	Shared Neighborhood Hits	215
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RN5A_HUMAN
θ value	0.21417 (rank : 331)	NC score	0.358030 (rank : 181)
Query Neighborhood Hits	599	Target Neighborhood Hits	608	Shared Neighborhood Hits	240
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

RUSC1_HUMAN
θ value	0.21417 (rank : 332)	NC score	0.146974 (rank : 393)
Query Neighborhood Hits	599	Target Neighborhood Hits	226	Shared Neighborhood Hits	128
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

SPTA1_HUMAN
θ value	0.21417 (rank : 333)	NC score	0.094886 (rank : 460)
Query Neighborhood Hits	599	Target Neighborhood Hits	748	Shared Neighborhood Hits	176
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SRBS1_HUMAN
θ value	0.21417 (rank : 334)	NC score	0.235263 (rank : 296)
Query Neighborhood Hits	599	Target Neighborhood Hits	396	Shared Neighborhood Hits	173
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	0.21417 (rank : 335)	NC score	0.239304 (rank : 288)
Query Neighborhood Hits	599	Target Neighborhood Hits	409	Shared Neighborhood Hits	177
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

TARSH_HUMAN
θ value	0.21417 (rank : 336)	NC score	0.068190 (rank : 512)
Query Neighborhood Hits	599	Target Neighborhood Hits	768	Shared Neighborhood Hits	96
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

ZN385_HUMAN
θ value	0.21417 (rank : 337)	NC score	0.041434 (rank : 656)
Query Neighborhood Hits	599	Target Neighborhood Hits	614	Shared Neighborhood Hits	49
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

ANFY1_MOUSE
θ value	0.279714 (rank : 338)	NC score	0.351417 (rank : 189)
Query Neighborhood Hits	599	Target Neighborhood Hits	480	Shared Neighborhood Hits	235
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ASB5_MOUSE
θ value	0.279714 (rank : 339)	NC score	0.359552 (rank : 177)
Query Neighborhood Hits	599	Target Neighborhood Hits	266	Shared Neighborhood Hits	218
SwissProt Accessions	Q9D1A4	Gene names	Asb5
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 5 (ASB-5).

ES8L2_MOUSE
θ value	0.279714 (rank : 340)	NC score	0.107321 (rank : 439)
Query Neighborhood Hits	599	Target Neighborhood Hits	169	Shared Neighborhood Hits	92
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

HCK_MOUSE
θ value	0.279714 (rank : 341)	NC score	0.038778 (rank : 671)
Query Neighborhood Hits	599	Target Neighborhood Hits	1029	Shared Neighborhood Hits	150
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

MYO15_MOUSE
θ value	0.279714 (rank : 342)	NC score	0.039117 (rank : 668)
Query Neighborhood Hits	599	Target Neighborhood Hits	467	Shared Neighborhood Hits	84
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

NFH_MOUSE
θ value	0.279714 (rank : 343)	NC score	0.036408 (rank : 687)
Query Neighborhood Hits	599	Target Neighborhood Hits	2247	Shared Neighborhood Hits	171
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

OSBL1_HUMAN
θ value	0.279714 (rank : 344)	NC score	0.330616 (rank : 208)
Query Neighborhood Hits	599	Target Neighborhood Hits	368	Shared Neighborhood Hits	246
SwissProt Accessions	Q9BXW6, Q9BZF5, Q9NW87	Gene names	OSBPL1A, ORP1, OSBP8, OSBPL1
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

STS2_HUMAN
θ value	0.279714 (rank : 345)	NC score	0.104192 (rank : 443)
Query Neighborhood Hits	599	Target Neighborhood Hits	108	Shared Neighborhood Hits	80
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

UACA_MOUSE
θ value	0.279714 (rank : 346)	NC score	0.245262 (rank : 283)
Query Neighborhood Hits	599	Target Neighborhood Hits	1620	Shared Neighborhood Hits	302
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

VAV2_MOUSE
θ value	0.279714 (rank : 347)	NC score	0.143367 (rank : 396)
Query Neighborhood Hits	599	Target Neighborhood Hits	456	Shared Neighborhood Hits	156
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ANKS1_HUMAN
θ value	0.365318 (rank : 348)	NC score	0.376391 (rank : 145)
Query Neighborhood Hits	599	Target Neighborhood Hits	438	Shared Neighborhood Hits	236
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

ANR15_HUMAN
θ value	0.365318 (rank : 349)	NC score	0.340683 (rank : 198)
Query Neighborhood Hits	599	Target Neighborhood Hits	478	Shared Neighborhood Hits	247
SwissProt Accessions	Q14678, Q5W0W0, Q8IY65, Q8WX74	Gene names	ANKRD15, KANK, KIAA0172
Domain Architecture
Description	Ankyrin repeat domain-containing protein 15 (Kidney ankyrin repeat- containing protein).

ASB4_HUMAN
θ value	0.365318 (rank : 350)	NC score	0.370768 (rank : 157)
Query Neighborhood Hits	599	Target Neighborhood Hits	264	Shared Neighborhood Hits	222
SwissProt Accessions	Q9Y574, O14586	Gene names	ASB4
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 4 (ASB-4).

ASPP1_HUMAN
θ value	0.365318 (rank : 351)	NC score	0.359268 (rank : 179)
Query Neighborhood Hits	599	Target Neighborhood Hits	956	Shared Neighborhood Hits	404
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

DOCK2_MOUSE
θ value	0.365318 (rank : 352)	NC score	0.052424 (rank : 613)
Query Neighborhood Hits	599	Target Neighborhood Hits	104	Shared Neighborhood Hits	41
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

HCLS1_MOUSE
θ value	0.365318 (rank : 353)	NC score	0.230983 (rank : 300)
Query Neighborhood Hits	599	Target Neighborhood Hits	329	Shared Neighborhood Hits	159
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HLF_HUMAN
θ value	0.365318 (rank : 354)	NC score	0.027421 (rank : 721)
Query Neighborhood Hits	599	Target Neighborhood Hits	75	Shared Neighborhood Hits	16
SwissProt Accessions	Q16534	Gene names	HLF
Domain Architecture
Description	Hepatic leukemia factor.

KSR1_HUMAN
θ value	0.365318 (rank : 355)	NC score	0.011358 (rank : 753)
Query Neighborhood Hits	599	Target Neighborhood Hits	867	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

MTMRD_HUMAN
θ value	0.365318 (rank : 356)	NC score	0.046219 (rank : 633)
Query Neighborhood Hits	599	Target Neighborhood Hits	135	Shared Neighborhood Hits	33
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

PO6F1_MOUSE
θ value	0.365318 (rank : 357)	NC score	0.010017 (rank : 755)
Query Neighborhood Hits	599	Target Neighborhood Hits	581	Shared Neighborhood Hits	39
SwissProt Accessions	Q07916, Q91XK3	Gene names	Pou6f1, Emb
Domain Architecture
Description	POU domain, class 6, transcription factor 1 (Octamer-binding transcription factor EMB) (Transcription regulatory protein MCP-1).

POT14_HUMAN
θ value	0.365318 (rank : 358)	NC score	0.345985 (rank : 195)
Query Neighborhood Hits	599	Target Neighborhood Hits	403	Shared Neighborhood Hits	231
SwissProt Accessions	Q6S5H5, Q6S5H6, Q6S8J2	Gene names	POTE14
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 14.

PPRB_MOUSE
θ value	0.365318 (rank : 359)	NC score	0.053661 (rank : 603)
Query Neighborhood Hits	599	Target Neighborhood Hits	354	Shared Neighborhood Hits	60
SwissProt Accessions	Q925J9, O88323, Q3UHV0, Q6AXD5, Q8BW37, Q8BX19, Q8VDQ7, Q925K0	Gene names	Pparbp, Trip2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2).

VAV2_HUMAN
θ value	0.365318 (rank : 360)	NC score	0.143189 (rank : 397)
Query Neighborhood Hits	599	Target Neighborhood Hits	453	Shared Neighborhood Hits	156
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

BTK_MOUSE
θ value	0.47712 (rank : 361)	NC score	0.042929 (rank : 650)
Query Neighborhood Hits	599	Target Neighborhood Hits	1017	Shared Neighborhood Hits	145
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CK024_HUMAN
θ value	0.47712 (rank : 362)	NC score	0.067462 (rank : 518)
Query Neighborhood Hits	599	Target Neighborhood Hits	408	Shared Neighborhood Hits	69
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

FGD4_MOUSE
θ value	0.47712 (rank : 363)	NC score	0.082608 (rank : 482)
Query Neighborhood Hits	599	Target Neighborhood Hits	227	Shared Neighborhood Hits	61
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

MAST4_HUMAN
θ value	0.47712 (rank : 364)	NC score	0.010287 (rank : 754)
Query Neighborhood Hits	599	Target Neighborhood Hits	1804	Shared Neighborhood Hits	120
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MUCDL_HUMAN
θ value	0.47712 (rank : 365)	NC score	0.049057 (rank : 629)
Query Neighborhood Hits	599	Target Neighborhood Hits	777	Shared Neighborhood Hits	91
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

NUD12_MOUSE
θ value	0.47712 (rank : 366)	NC score	0.284874 (rank : 239)
Query Neighborhood Hits	599	Target Neighborhood Hits	243	Shared Neighborhood Hits	193
SwissProt Accessions	Q9DCN1, Q6PFA5	Gene names	Nudt12
Domain Architecture	No domain graphic available
Description	Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12).

RIMB2_HUMAN
θ value	0.47712 (rank : 367)	NC score	0.143850 (rank : 395)
Query Neighborhood Hits	599	Target Neighborhood Hits	263	Shared Neighborhood Hits	107
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

ANKS3_HUMAN
θ value	0.62314 (rank : 368)	NC score	0.370713 (rank : 158)
Query Neighborhood Hits	599	Target Neighborhood Hits	355	Shared Neighborhood Hits	233
SwissProt Accessions	Q6ZW76, Q8TF25	Gene names	ANKS3, KIAA1977
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 3.

ANR40_HUMAN
θ value	0.62314 (rank : 369)	NC score	0.263608 (rank : 261)
Query Neighborhood Hits	599	Target Neighborhood Hits	224	Shared Neighborhood Hits	187
SwissProt Accessions	Q6AI12, Q96E32	Gene names	ANKRD40
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 40.

ASB7_HUMAN
θ value	0.62314 (rank : 370)	NC score	0.398955 (rank : 110)
Query Neighborhood Hits	599	Target Neighborhood Hits	296	Shared Neighborhood Hits	228
SwissProt Accessions	Q9H672, Q7Z4S3	Gene names	ASB7
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 7 (ASB-7).

ASB7_MOUSE
θ value	0.62314 (rank : 371)	NC score	0.398904 (rank : 111)
Query Neighborhood Hits	599	Target Neighborhood Hits	296	Shared Neighborhood Hits	228
SwissProt Accessions	Q91ZU0	Gene names	Asb7
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 7 (ASB-7).

BCOR_MOUSE
θ value	0.62314 (rank : 372)	NC score	0.316777 (rank : 220)
Query Neighborhood Hits	599	Target Neighborhood Hits	521	Shared Neighborhood Hits	235
SwissProt Accessions	Q8CGN4, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3	Gene names	Bcor, Kiaa1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

DAPP1_MOUSE
θ value	0.62314 (rank : 373)	NC score	0.096729 (rank : 458)
Query Neighborhood Hits	599	Target Neighborhood Hits	225	Shared Neighborhood Hits	56
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

EPS8_HUMAN
θ value	0.62314 (rank : 374)	NC score	0.100932 (rank : 451)
Query Neighborhood Hits	599	Target Neighborhood Hits	151	Shared Neighborhood Hits	96
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

GPS2_HUMAN
θ value	0.62314 (rank : 375)	NC score	0.049553 (rank : 628)
Query Neighborhood Hits	599	Target Neighborhood Hits	459	Shared Neighborhood Hits	61
SwissProt Accessions	Q13227	Gene names	GPS2
Domain Architecture	No domain graphic available
Description	G protein pathway suppressor 2 (Protein GPS2).

K1543_MOUSE
θ value	0.62314 (rank : 376)	NC score	0.067836 (rank : 516)
Query Neighborhood Hits	599	Target Neighborhood Hits	497	Shared Neighborhood Hits	77
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

LARP4_MOUSE
θ value	0.62314 (rank : 377)	NC score	0.035187 (rank : 693)
Query Neighborhood Hits	599	Target Neighborhood Hits	260	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BWW4, Q3UR69	Gene names	Larp4
Domain Architecture	No domain graphic available
Description	La-related protein 4 (La ribonucleoprotein domain family member 4).

OSBL1_MOUSE
θ value	0.62314 (rank : 378)	NC score	0.324029 (rank : 218)
Query Neighborhood Hits	599	Target Neighborhood Hits	336	Shared Neighborhood Hits	240
SwissProt Accessions	Q91XL9, O88318, Q3TH97, Q673L8, Q6DFU6	Gene names	Osbpl1a, Orp1, Orp1a
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

PPRB_HUMAN
θ value	0.62314 (rank : 379)	NC score	0.045022 (rank : 639)
Query Neighborhood Hits	599	Target Neighborhood Hits	311	Shared Neighborhood Hits	41
SwissProt Accessions	Q15648, O43810, O75447, Q9HD39	Gene names	PPARBP, ARC205, DRIP205, TRAP220, TRIP2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2) (p53 regulatory protein RB18A) (Vitamin D receptor-interacting protein complex component DRIP205) (Activator- recruited cofactor 205 kDa component) (ARC205).

SPTA2_HUMAN
θ value	0.62314 (rank : 380)	NC score	0.099396 (rank : 454)
Query Neighborhood Hits	599	Target Neighborhood Hits	888	Shared Neighborhood Hits	189
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SRC8_HUMAN
θ value	0.62314 (rank : 381)	NC score	0.224699 (rank : 308)
Query Neighborhood Hits	599	Target Neighborhood Hits	269	Shared Neighborhood Hits	146
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	0.62314 (rank : 382)	NC score	0.220817 (rank : 314)
Query Neighborhood Hits	599	Target Neighborhood Hits	292	Shared Neighborhood Hits	145
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

ANFY1_HUMAN
θ value	0.813845 (rank : 383)	NC score	0.351326 (rank : 190)
Query Neighborhood Hits	599	Target Neighborhood Hits	480	Shared Neighborhood Hits	235
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANKR9_HUMAN
θ value	0.813845 (rank : 384)	NC score	0.158298 (rank : 387)
Query Neighborhood Hits	599	Target Neighborhood Hits	99	Shared Neighborhood Hits	92
SwissProt Accessions	Q96BM1	Gene names	ANKRD9
Domain Architecture
Description	Ankyrin repeat domain-containing protein 9.

ANR26_HUMAN
θ value	0.813845 (rank : 385)	NC score	0.226563 (rank : 304)
Query Neighborhood Hits	599	Target Neighborhood Hits	1614	Shared Neighborhood Hits	299
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

ANR32_HUMAN
θ value	0.813845 (rank : 386)	NC score	0.333914 (rank : 206)
Query Neighborhood Hits	599	Target Neighborhood Hits	270	Shared Neighborhood Hits	217
SwissProt Accessions	Q9BQI6	Gene names	ANKRD32
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 32.

ANR40_MOUSE
θ value	0.813845 (rank : 387)	NC score	0.260494 (rank : 265)
Query Neighborhood Hits	599	Target Neighborhood Hits	228	Shared Neighborhood Hits	190
SwissProt Accessions	Q5SUE8, Q8R595, Q9CU71	Gene names	Ankrd40
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 40.

ASB1_HUMAN
θ value	0.813845 (rank : 388)	NC score	0.353258 (rank : 186)
Query Neighborhood Hits	599	Target Neighborhood Hits	291	Shared Neighborhood Hits	224
SwissProt Accessions	Q9Y576, Q9ULS4	Gene names	ASB1, KIAA1146
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 1 (ASB-1).

BI2L1_MOUSE
θ value	0.813845 (rank : 389)	NC score	0.091534 (rank : 462)
Query Neighborhood Hits	599	Target Neighborhood Hits	197	Shared Neighborhood Hits	66
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BSN_MOUSE
θ value	0.813845 (rank : 390)	NC score	0.080556 (rank : 487)
Query Neighborhood Hits	599	Target Neighborhood Hits	2057	Shared Neighborhood Hits	203
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CR034_HUMAN
θ value	0.813845 (rank : 391)	NC score	0.038549 (rank : 672)
Query Neighborhood Hits	599	Target Neighborhood Hits	538	Shared Neighborhood Hits	65
SwissProt Accessions	Q5BJE1, Q6ZP67, Q6ZU20	Gene names	C18orf34
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34.

HLF_MOUSE
θ value	0.813845 (rank : 392)	NC score	0.026377 (rank : 725)
Query Neighborhood Hits	599	Target Neighborhood Hits	74	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BW74, Q6PF83	Gene names	Hlf
Domain Architecture	No domain graphic available
Description	Hepatic leukemia factor.

PCLO_MOUSE
θ value	0.813845 (rank : 393)	NC score	0.066339 (rank : 524)
Query Neighborhood Hits	599	Target Neighborhood Hits	2275	Shared Neighborhood Hits	202
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PHLB2_MOUSE
θ value	0.813845 (rank : 394)	NC score	0.045638 (rank : 637)
Query Neighborhood Hits	599	Target Neighborhood Hits	1016	Shared Neighborhood Hits	101
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PRR8_HUMAN
θ value	0.813845 (rank : 395)	NC score	0.051797 (rank : 615)
Query Neighborhood Hits	599	Target Neighborhood Hits	217	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NSV0	Gene names	PRR8
Domain Architecture	No domain graphic available
Description	Proline-rich protein 8.

RUSC1_MOUSE
θ value	0.813845 (rank : 396)	NC score	0.130991 (rank : 409)
Query Neighborhood Hits	599	Target Neighborhood Hits	206	Shared Neighborhood Hits	116
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

SDPR_MOUSE
θ value	0.813845 (rank : 397)	NC score	0.031836 (rank : 706)
Query Neighborhood Hits	599	Target Neighborhood Hits	485	Shared Neighborhood Hits	46
SwissProt Accessions	Q63918, Q3V1P6, Q78EC3, Q8CBT4	Gene names	Sdpr, Sdr
Domain Architecture	No domain graphic available
Description	Serum deprivation-response protein (Phosphatidylserine-binding protein).

SELPL_MOUSE
θ value	0.813845 (rank : 398)	NC score	0.048952 (rank : 630)
Query Neighborhood Hits	599	Target Neighborhood Hits	588	Shared Neighborhood Hits	68
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

SPTB2_MOUSE
θ value	0.813845 (rank : 399)	NC score	0.029971 (rank : 710)
Query Neighborhood Hits	599	Target Neighborhood Hits	770	Shared Neighborhood Hits	83
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

ANKS6_HUMAN
θ value	1.06291 (rank : 400)	NC score	0.373211 (rank : 154)
Query Neighborhood Hits	599	Target Neighborhood Hits	411	Shared Neighborhood Hits	246
SwissProt Accessions	Q68DC2, Q5VSL0, Q5VSL2, Q5VSL3, Q5VSL4, Q68DB8, Q6P2R2, Q8N9L6, Q96D62	Gene names	ANKS6, ANKRD14, SAMD6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6) (Ankyrin repeat domain-containing protein 14).

ANR32_MOUSE
θ value	1.06291 (rank : 401)	NC score	0.331772 (rank : 207)
Query Neighborhood Hits	599	Target Neighborhood Hits	285	Shared Neighborhood Hits	219
SwissProt Accessions	Q8R3P9, Q5XK30, Q8BHY5, Q921Y9	Gene names	Ankrd32
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 32.

CBP_MOUSE
θ value	1.06291 (rank : 402)	NC score	0.044256 (rank : 642)
Query Neighborhood Hits	599	Target Neighborhood Hits	1051	Shared Neighborhood Hits	126
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CP26B_HUMAN
θ value	1.06291 (rank : 403)	NC score	0.008036 (rank : 760)
Query Neighborhood Hits	599	Target Neighborhood Hits	114	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NR63, Q53TW1, Q9NP41	Gene names	CYP26B1, CYP26A2, P450RAI2
Domain Architecture
Description	Cytochrome P450 26B1 (EC 1.14.-.-) (P450 26A2) (P450 retinoic acid- inactivating 2) (P450RAI-2) (Retinoic acid-metabolizing cytochrome).

FGD6_HUMAN
θ value	1.06291 (rank : 404)	NC score	0.055362 (rank : 590)
Query Neighborhood Hits	599	Target Neighborhood Hits	237	Shared Neighborhood Hits	50
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

MDC1_MOUSE
θ value	1.06291 (rank : 405)	NC score	0.053818 (rank : 602)
Query Neighborhood Hits	599	Target Neighborhood Hits	998	Shared Neighborhood Hits	108
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MYO15_HUMAN
θ value	1.06291 (rank : 406)	NC score	0.036834 (rank : 685)
Query Neighborhood Hits	599	Target Neighborhood Hits	671	Shared Neighborhood Hits	87
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

NCF1_HUMAN
θ value	1.06291 (rank : 407)	NC score	0.176221 (rank : 375)
Query Neighborhood Hits	599	Target Neighborhood Hits	198	Shared Neighborhood Hits	129
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NFKB2_MOUSE
θ value	1.06291 (rank : 408)	NC score	0.326078 (rank : 217)
Query Neighborhood Hits	599	Target Neighborhood Hits	326	Shared Neighborhood Hits	226
SwissProt Accessions	Q9WTK5	Gene names	Nfkb2
Domain Architecture
Description	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) [Contains: Nuclear factor NF-kappa-B p52 subunit].

PLCG2_HUMAN
θ value	1.06291 (rank : 409)	NC score	0.131943 (rank : 408)
Query Neighborhood Hits	599	Target Neighborhood Hits	280	Shared Neighborhood Hits	120
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

POT22_HUMAN
θ value	1.06291 (rank : 410)	NC score	0.326387 (rank : 215)
Query Neighborhood Hits	599	Target Neighborhood Hits	266	Shared Neighborhood Hits	218
SwissProt Accessions	Q6S545	Gene names	ACTBL1, POTE22
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 22.

TEC_MOUSE
θ value	1.06291 (rank : 411)	NC score	0.030368 (rank : 708)
Query Neighborhood Hits	599	Target Neighborhood Hits	1006	Shared Neighborhood Hits	130
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TUFT1_HUMAN
θ value	1.06291 (rank : 412)	NC score	0.042215 (rank : 652)
Query Neighborhood Hits	599	Target Neighborhood Hits	686	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NNX1, Q5T384, Q5T385, Q9BU28, Q9H5L1	Gene names	TUFT1
Domain Architecture	No domain graphic available
Description	Tuftelin.

ZN507_HUMAN
θ value	1.06291 (rank : 413)	NC score	-0.008379 (rank : 787)
Query Neighborhood Hits	599	Target Neighborhood Hits	739	Shared Neighborhood Hits	13
SwissProt Accessions	Q8TCN5	Gene names	ZNF507
Domain Architecture	No domain graphic available
Description	Zinc finger protein 507.

ARHGG_MOUSE
θ value	1.38821 (rank : 414)	NC score	0.101390 (rank : 449)
Query Neighborhood Hits	599	Target Neighborhood Hits	152	Shared Neighborhood Hits	75
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ASB14_MOUSE
θ value	1.38821 (rank : 415)	NC score	0.364852 (rank : 174)
Query Neighborhood Hits	599	Target Neighborhood Hits	293	Shared Neighborhood Hits	228
SwissProt Accessions	Q8VHS7	Gene names	Asb14
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 14 (ASB-14).

ASB1_MOUSE
θ value	1.38821 (rank : 416)	NC score	0.350569 (rank : 191)
Query Neighborhood Hits	599	Target Neighborhood Hits	292	Shared Neighborhood Hits	222
SwissProt Accessions	Q9WV74	Gene names	Asb1
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 1 (ASB-1).

CI093_HUMAN
θ value	1.38821 (rank : 417)	NC score	0.039879 (rank : 664)
Query Neighborhood Hits	599	Target Neighborhood Hits	1088	Shared Neighborhood Hits	93
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

DGKZ_HUMAN
θ value	1.38821 (rank : 418)	NC score	0.182412 (rank : 367)
Query Neighborhood Hits	599	Target Neighborhood Hits	551	Shared Neighborhood Hits	194
SwissProt Accessions	Q13574, O00542	Gene names	DGKZ, DAGK6
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

DOCK2_HUMAN
θ value	1.38821 (rank : 419)	NC score	0.046436 (rank : 632)
Query Neighborhood Hits	599	Target Neighborhood Hits	90	Shared Neighborhood Hits	46
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

ES8L2_HUMAN
θ value	1.38821 (rank : 420)	NC score	0.108885 (rank : 437)
Query Neighborhood Hits	599	Target Neighborhood Hits	193	Shared Neighborhood Hits	98
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

FOG2_HUMAN
θ value	1.38821 (rank : 421)	NC score	-0.001564 (rank : 783)
Query Neighborhood Hits	599	Target Neighborhood Hits	731	Shared Neighborhood Hits	14
SwissProt Accessions	Q8WW38, Q9NPL7, Q9NPS4, Q9UNI5	Gene names	ZFPM2, FOG2
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM2 (Zinc finger protein multitype 2) (Friend of GATA protein 2) (FOG-2) (hFOG-2).

MDC1_HUMAN
θ value	1.38821 (rank : 422)	NC score	0.068091 (rank : 513)
Query Neighborhood Hits	599	Target Neighborhood Hits	1446	Shared Neighborhood Hits	135
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

PLCG1_HUMAN
θ value	1.38821 (rank : 423)	NC score	0.128808 (rank : 411)
Query Neighborhood Hits	599	Target Neighborhood Hits	293	Shared Neighborhood Hits	124
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SETBP_HUMAN
θ value	1.38821 (rank : 424)	NC score	0.025145 (rank : 728)
Query Neighborhood Hits	599	Target Neighborhood Hits	305	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y6X0, Q9UEF3	Gene names	SETBP1, KIAA0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

SF3B1_HUMAN
θ value	1.38821 (rank : 425)	NC score	0.043366 (rank : 647)
Query Neighborhood Hits	599	Target Neighborhood Hits	341	Shared Neighborhood Hits	48
SwissProt Accessions	O75533	Gene names	SF3B1, SAP155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SF3B1_MOUSE
θ value	1.38821 (rank : 426)	NC score	0.043536 (rank : 644)
Query Neighborhood Hits	599	Target Neighborhood Hits	352	Shared Neighborhood Hits	50
SwissProt Accessions	Q99NB9, Q9CSK5	Gene names	Sf3b1, Sap155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

UACA_HUMAN
θ value	1.38821 (rank : 427)	NC score	0.253865 (rank : 271)
Query Neighborhood Hits	599	Target Neighborhood Hits	1622	Shared Neighborhood Hits	306
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

AL2S4_MOUSE
θ value	1.81305 (rank : 428)	NC score	0.024339 (rank : 730)
Query Neighborhood Hits	599	Target Neighborhood Hits	193	Shared Neighborhood Hits	26
SwissProt Accessions	Q3V0J1, Q3TIS2	Gene names	Als2cr4
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog.

ANR38_MOUSE
θ value	1.81305 (rank : 429)	NC score	0.262296 (rank : 264)
Query Neighborhood Hits	599	Target Neighborhood Hits	512	Shared Neighborhood Hits	228
SwissProt Accessions	Q6P9J5, Q8BV03	Gene names	Ankrd38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

ARHG5_HUMAN
θ value	1.81305 (rank : 430)	NC score	0.103459 (rank : 445)
Query Neighborhood Hits	599	Target Neighborhood Hits	172	Shared Neighborhood Hits	89
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

BAG3_MOUSE
θ value	1.81305 (rank : 431)	NC score	0.036082 (rank : 689)
Query Neighborhood Hits	599	Target Neighborhood Hits	513	Shared Neighborhood Hits	70
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

CT012_HUMAN
θ value	1.81305 (rank : 432)	NC score	0.177035 (rank : 373)
Query Neighborhood Hits	599	Target Neighborhood Hits	205	Shared Neighborhood Hits	147
SwissProt Accessions	Q9NVP4, Q4F7X1, Q5QPD9, Q5QPE0, Q68DN8, Q6ZMX9, Q96NF0, Q9H1E0, Q9H442	Gene names	C20orf12
Domain Architecture
Description	Protein C20orf12.

CT032_HUMAN
θ value	1.81305 (rank : 433)	NC score	0.176652 (rank : 374)
Query Neighborhood Hits	599	Target Neighborhood Hits	235	Shared Neighborhood Hits	134
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

K0555_HUMAN
θ value	1.81305 (rank : 434)	NC score	0.042985 (rank : 649)
Query Neighborhood Hits	599	Target Neighborhood Hits	880	Shared Neighborhood Hits	89
SwissProt Accessions	Q96AA8, O60302	Gene names	KIAA0555
Domain Architecture	No domain graphic available
Description	Protein KIAA0555.

M3K9_HUMAN
θ value	1.81305 (rank : 435)	NC score	0.049961 (rank : 627)
Query Neighborhood Hits	599	Target Neighborhood Hits	1123	Shared Neighborhood Hits	167
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

MPP5_HUMAN
θ value	1.81305 (rank : 436)	NC score	0.041758 (rank : 654)
Query Neighborhood Hits	599	Target Neighborhood Hits	231	Shared Neighborhood Hits	61
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	1.81305 (rank : 437)	NC score	0.041457 (rank : 655)
Query Neighborhood Hits	599	Target Neighborhood Hits	226	Shared Neighborhood Hits	60
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

NFKB2_HUMAN
θ value	1.81305 (rank : 438)	NC score	0.329559 (rank : 209)
Query Neighborhood Hits	599	Target Neighborhood Hits	325	Shared Neighborhood Hits	229
SwissProt Accessions	Q00653, Q04860, Q9BU75, Q9H471, Q9H472	Gene names	NFKB2, LYT10
Domain Architecture
Description	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10) (Oncogene Lyt-10) (Lyt10) [Contains: Nuclear factor NF-kappa-B p52 subunit].

PER3_HUMAN
θ value	1.81305 (rank : 439)	NC score	0.026682 (rank : 723)
Query Neighborhood Hits	599	Target Neighborhood Hits	479	Shared Neighborhood Hits	55
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

PHF8_HUMAN
θ value	1.81305 (rank : 440)	NC score	0.011691 (rank : 752)
Query Neighborhood Hits	599	Target Neighborhood Hits	105	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UPP1, Q5H9U5, Q5VUJ4, Q7Z6D4, Q9HAH2	Gene names	PHF8, KIAA1111, ZNF422
Domain Architecture	No domain graphic available
Description	PHD finger protein 8.

SM1L2_HUMAN
θ value	1.81305 (rank : 441)	NC score	0.035379 (rank : 691)
Query Neighborhood Hits	599	Target Neighborhood Hits	1019	Shared Neighborhood Hits	87
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

ZIMP7_MOUSE
θ value	1.81305 (rank : 442)	NC score	0.028938 (rank : 716)
Query Neighborhood Hits	599	Target Neighborhood Hits	566	Shared Neighborhood Hits	61
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

ASB9_HUMAN
θ value	2.36792 (rank : 443)	NC score	0.364434 (rank : 175)
Query Neighborhood Hits	599	Target Neighborhood Hits	267	Shared Neighborhood Hits	218
SwissProt Accessions	Q96DX5, Q9NWS5, Q9Y4T3	Gene names	ASB9
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 9 (ASB-9).

BCOR_HUMAN
θ value	2.36792 (rank : 444)	NC score	0.309830 (rank : 226)
Query Neighborhood Hits	599	Target Neighborhood Hits	609	Shared Neighborhood Hits	244
SwissProt Accessions	Q6W2J9, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2	Gene names	BCOR, KIAA1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

CENPE_HUMAN
θ value	2.36792 (rank : 445)	NC score	0.034379 (rank : 699)
Query Neighborhood Hits	599	Target Neighborhood Hits	2060	Shared Neighborhood Hits	136
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

CIC_HUMAN
θ value	2.36792 (rank : 446)	NC score	0.037640 (rank : 678)
Query Neighborhood Hits	599	Target Neighborhood Hits	992	Shared Neighborhood Hits	116
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

EEA1_HUMAN
θ value	2.36792 (rank : 447)	NC score	0.042050 (rank : 653)
Query Neighborhood Hits	599	Target Neighborhood Hits	1796	Shared Neighborhood Hits	130
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

EM55_HUMAN
θ value	2.36792 (rank : 448)	NC score	0.060232 (rank : 564)
Query Neighborhood Hits	599	Target Neighborhood Hits	228	Shared Neighborhood Hits	80
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

EXOC8_HUMAN
θ value	2.36792 (rank : 449)	NC score	0.028020 (rank : 718)
Query Neighborhood Hits	599	Target Neighborhood Hits	46	Shared Neighborhood Hits	10
SwissProt Accessions	Q8IYI6, Q5TE82	Gene names	EXOC8
Domain Architecture	No domain graphic available
Description	Exocyst complex component 8 (Exocyst complex 84 kDa subunit).

GCC2_HUMAN
θ value	2.36792 (rank : 450)	NC score	0.040887 (rank : 660)
Query Neighborhood Hits	599	Target Neighborhood Hits	1558	Shared Neighborhood Hits	118
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

GOGA5_HUMAN
θ value	2.36792 (rank : 451)	NC score	0.035858 (rank : 690)
Query Neighborhood Hits	599	Target Neighborhood Hits	1168	Shared Neighborhood Hits	92
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

K1543_HUMAN
θ value	2.36792 (rank : 452)	NC score	0.039070 (rank : 670)
Query Neighborhood Hits	599	Target Neighborhood Hits	435	Shared Neighborhood Hits	51
SwissProt Accessions	Q9P1Y5, Q8NDF1	Gene names	KIAA1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

MAML1_HUMAN
θ value	2.36792 (rank : 453)	NC score	0.027602 (rank : 719)
Query Neighborhood Hits	599	Target Neighborhood Hits	228	Shared Neighborhood Hits	34
SwissProt Accessions	Q92585, Q9NZ12	Gene names	MAML1, KIAA0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

MLL3_HUMAN
θ value	2.36792 (rank : 454)	NC score	0.044276 (rank : 641)
Query Neighborhood Hits	599	Target Neighborhood Hits	1644	Shared Neighborhood Hits	146
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

R3HD2_MOUSE
θ value	2.36792 (rank : 455)	NC score	0.032362 (rank : 703)
Query Neighborhood Hits	599	Target Neighborhood Hits	397	Shared Neighborhood Hits	47
SwissProt Accessions	Q80TM6, Q80YB1, Q8BLS5, Q9CW50	Gene names	R3hdm2, Kiaa1002
Domain Architecture
Description	R3H domain-containing protein 2.

RBP24_HUMAN
θ value	2.36792 (rank : 456)	NC score	0.040962 (rank : 659)
Query Neighborhood Hits	599	Target Neighborhood Hits	1559	Shared Neighborhood Hits	118
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

SFR14_MOUSE
θ value	2.36792 (rank : 457)	NC score	0.012919 (rank : 750)
Query Neighborhood Hits	599	Target Neighborhood Hits	238	Shared Neighborhood Hits	16
SwissProt Accessions	Q8CH09, Q6PG19, Q80UY8, Q8BY32, Q8CFM0	Gene names	Sfrs14
Domain Architecture	No domain graphic available
Description	Putative splicing factor, arginine/serine-rich 14 (Arginine/serine- rich-splicing factor 14).

SMAL1_HUMAN
θ value	2.36792 (rank : 458)	NC score	0.009182 (rank : 757)
Query Neighborhood Hits	599	Target Neighborhood Hits	174	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NZC9, Q96AY1, Q9NXQ5, Q9UFH3, Q9UI93	Gene names	SMARCAL1, HARP
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (hHARP).

SPTB2_HUMAN
θ value	2.36792 (rank : 459)	NC score	0.025732 (rank : 727)
Query Neighborhood Hits	599	Target Neighborhood Hits	748	Shared Neighborhood Hits	78
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

TITIN_HUMAN
θ value	2.36792 (rank : 460)	NC score	0.006718 (rank : 764)
Query Neighborhood Hits	599	Target Neighborhood Hits	2923	Shared Neighborhood Hits	176
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

ZN516_MOUSE
θ value	2.36792 (rank : 461)	NC score	-0.003590 (rank : 786)
Query Neighborhood Hits	599	Target Neighborhood Hits	1197	Shared Neighborhood Hits	61
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

ADA12_MOUSE
θ value	3.0926 (rank : 462)	NC score	0.008064 (rank : 758)
Query Neighborhood Hits	599	Target Neighborhood Hits	474	Shared Neighborhood Hits	48
SwissProt Accessions	Q61824	Gene names	Adam12, Mltna
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

ANR11_HUMAN
θ value	3.0926 (rank : 463)	NC score	0.342647 (rank : 197)
Query Neighborhood Hits	599	Target Neighborhood Hits	1289	Shared Neighborhood Hits	314
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

ANR38_HUMAN
θ value	3.0926 (rank : 464)	NC score	0.273742 (rank : 246)
Query Neighborhood Hits	599	Target Neighborhood Hits	443	Shared Neighborhood Hits	224
SwissProt Accessions	Q5T7N3, Q6P9A0, Q86T71, Q86VE6, Q8NAX3	Gene names	ANKRD38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

ASPP2_HUMAN
θ value	3.0926 (rank : 465)	NC score	0.349734 (rank : 192)
Query Neighborhood Hits	599	Target Neighborhood Hits	1156	Shared Neighborhood Hits	392
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

BAZ2A_MOUSE
θ value	3.0926 (rank : 466)	NC score	0.027344 (rank : 722)
Query Neighborhood Hits	599	Target Neighborhood Hits	744	Shared Neighborhood Hits	86
SwissProt Accessions	Q91YE5	Gene names	Baz2a, Tip5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5).

CASL_HUMAN
θ value	3.0926 (rank : 467)	NC score	0.138193 (rank : 400)
Query Neighborhood Hits	599	Target Neighborhood Hits	259	Shared Neighborhood Hits	132
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CEP63_HUMAN
θ value	3.0926 (rank : 468)	NC score	0.040447 (rank : 662)
Query Neighborhood Hits	599	Target Neighborhood Hits	1005	Shared Neighborhood Hits	92
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

CF182_MOUSE
θ value	3.0926 (rank : 469)	NC score	0.026551 (rank : 724)
Query Neighborhood Hits	599	Target Neighborhood Hits	551	Shared Neighborhood Hits	56
SwissProt Accessions	Q8VDS7, Q9CZE0, Q9D5A1	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf182 homolog.

DMD_HUMAN
θ value	3.0926 (rank : 470)	NC score	0.029880 (rank : 712)
Query Neighborhood Hits	599	Target Neighborhood Hits	1135	Shared Neighborhood Hits	97
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

EXOC8_MOUSE
θ value	3.0926 (rank : 471)	NC score	0.026105 (rank : 726)
Query Neighborhood Hits	599	Target Neighborhood Hits	43	Shared Neighborhood Hits	11
SwissProt Accessions	Q6PGF7	Gene names	Exoc8
Domain Architecture	No domain graphic available
Description	Exocyst complex component 8 (Exocyst complex 84 kDa subunit).

FARP1_HUMAN
θ value	3.0926 (rank : 472)	NC score	0.061299 (rank : 552)
Query Neighborhood Hits	599	Target Neighborhood Hits	241	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FGD4_HUMAN
θ value	3.0926 (rank : 473)	NC score	0.067672 (rank : 517)
Query Neighborhood Hits	599	Target Neighborhood Hits	219	Shared Neighborhood Hits	52
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGR_HUMAN
θ value	3.0926 (rank : 474)	NC score	0.045976 (rank : 634)
Query Neighborhood Hits	599	Target Neighborhood Hits	1067	Shared Neighborhood Hits	149
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FOXK2_HUMAN
θ value	3.0926 (rank : 475)	NC score	0.004323 (rank : 775)
Query Neighborhood Hits	599	Target Neighborhood Hits	190	Shared Neighborhood Hits	16
SwissProt Accessions	Q01167, Q13622, Q13623, Q13624	Gene names	FOXK2, ILF, ILF1
Domain Architecture
Description	Forkhead box protein K2 (Interleukin enhancer-binding factor 1) (Cellular transcription factor ILF-1).

GLTL5_HUMAN
θ value	3.0926 (rank : 476)	NC score	0.003388 (rank : 777)
Query Neighborhood Hits	599	Target Neighborhood Hits	45	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z4T8, Q75KN2, Q75MD3, Q8NCV4, Q8WW05, Q9UDR9	Gene names	GALNTL5, GALNT15
Domain Architecture	No domain graphic available
Description	Putative polypeptide N-acetylgalactosaminyltransferase-like protein 5 (EC 2.4.1.-) (Protein-UDP acetylgalactosaminyltransferase 15) (UDP- GalNAc:polypeptide N-acetylgalactosaminyltransferase 15) (Polypeptide GalNAc transferase 15) (GalNAc-T15) (pp-GaNTase 15).

MAP4_HUMAN
θ value	3.0926 (rank : 477)	NC score	0.037466 (rank : 681)
Query Neighborhood Hits	599	Target Neighborhood Hits	428	Shared Neighborhood Hits	58
SwissProt Accessions	P27816, Q13082, Q96A76	Gene names	MAP4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

OSBL6_HUMAN
θ value	3.0926 (rank : 478)	NC score	0.073665 (rank : 502)
Query Neighborhood Hits	599	Target Neighborhood Hits	101	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BZF3, Q7Z4Q1, Q96SR1	Gene names	OSBPL6, ORP6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

PCNT_HUMAN
θ value	3.0926 (rank : 479)	NC score	0.041054 (rank : 658)
Query Neighborhood Hits	599	Target Neighborhood Hits	1551	Shared Neighborhood Hits	127
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

PKHA5_HUMAN
θ value	3.0926 (rank : 480)	NC score	0.061767 (rank : 547)
Query Neighborhood Hits	599	Target Neighborhood Hits	455	Shared Neighborhood Hits	68
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

RECQ5_HUMAN
θ value	3.0926 (rank : 481)	NC score	0.015349 (rank : 747)
Query Neighborhood Hits	599	Target Neighborhood Hits	390	Shared Neighborhood Hits	38
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

RUSC2_MOUSE
θ value	3.0926 (rank : 482)	NC score	0.065585 (rank : 528)
Query Neighborhood Hits	599	Target Neighborhood Hits	305	Shared Neighborhood Hits	89
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SON_HUMAN
θ value	3.0926 (rank : 483)	NC score	0.055615 (rank : 589)
Query Neighborhood Hits	599	Target Neighborhood Hits	1568	Shared Neighborhood Hits	140
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

TEC_HUMAN
θ value	3.0926 (rank : 484)	NC score	0.029131 (rank : 715)
Query Neighborhood Hits	599	Target Neighborhood Hits	1006	Shared Neighborhood Hits	126
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TENS4_MOUSE
θ value	3.0926 (rank : 485)	NC score	0.036861 (rank : 684)
Query Neighborhood Hits	599	Target Neighborhood Hits	225	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

AKAP2_MOUSE
θ value	4.03905 (rank : 486)	NC score	0.028568 (rank : 717)
Query Neighborhood Hits	599	Target Neighborhood Hits	385	Shared Neighborhood Hits	54
SwissProt Accessions	O54931, O54932, O54933	Gene names	Akap2
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2) (AKAP expressed in kidney and lung) (AKAP-KL).

ATF6B_HUMAN
θ value	4.03905 (rank : 487)	NC score	0.014250 (rank : 748)
Query Neighborhood Hits	599	Target Neighborhood Hits	122	Shared Neighborhood Hits	22
SwissProt Accessions	Q99941, Q13269, Q14343, Q14345, Q99635, Q99637, Q9H3V9, Q9H3W1, Q9NPL0	Gene names	CREBL1, G13
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-6 beta (Activating transcription factor 6 beta) (ATF6-beta) (cAMP-responsive element- binding protein-like 1) (cAMP response element-binding protein-related protein) (Creb-rp) (Protein G13).

BI2L1_HUMAN
θ value	4.03905 (rank : 488)	NC score	0.099915 (rank : 452)
Query Neighborhood Hits	599	Target Neighborhood Hits	156	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BIN1_HUMAN
θ value	4.03905 (rank : 489)	NC score	0.110092 (rank : 435)
Query Neighborhood Hits	599	Target Neighborhood Hits	335	Shared Neighborhood Hits	115
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BIN1_MOUSE
θ value	4.03905 (rank : 490)	NC score	0.097435 (rank : 456)
Query Neighborhood Hits	599	Target Neighborhood Hits	283	Shared Neighborhood Hits	118
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

CD248_MOUSE
θ value	4.03905 (rank : 491)	NC score	0.018047 (rank : 741)
Query Neighborhood Hits	599	Target Neighborhood Hits	578	Shared Neighborhood Hits	51
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

DAPP1_HUMAN
θ value	4.03905 (rank : 492)	NC score	0.086945 (rank : 471)
Query Neighborhood Hits	599	Target Neighborhood Hits	227	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DLG2_MOUSE
θ value	4.03905 (rank : 493)	NC score	0.023910 (rank : 733)
Query Neighborhood Hits	599	Target Neighborhood Hits	271	Shared Neighborhood Hits	63
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

GOGA3_MOUSE
θ value	4.03905 (rank : 494)	NC score	0.034534 (rank : 697)
Query Neighborhood Hits	599	Target Neighborhood Hits	1437	Shared Neighborhood Hits	104
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

IKBA_HUMAN
θ value	4.03905 (rank : 495)	NC score	0.365338 (rank : 172)
Query Neighborhood Hits	599	Target Neighborhood Hits	280	Shared Neighborhood Hits	227
SwissProt Accessions	P25963	Gene names	NFKBIA, IKBA, MAD3, NFKBI
Domain Architecture
Description	NF-kappa-B inhibitor alpha (Major histocompatibility complex enhancer- binding protein MAD3) (I-kappa-B-alpha) (IkappaBalpha) (IKB-alpha).

K1802_HUMAN
θ value	4.03905 (rank : 496)	NC score	0.032109 (rank : 705)
Query Neighborhood Hits	599	Target Neighborhood Hits	1378	Shared Neighborhood Hits	112
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MEF2B_HUMAN
θ value	4.03905 (rank : 497)	NC score	0.018630 (rank : 740)
Query Neighborhood Hits	599	Target Neighborhood Hits	150	Shared Neighborhood Hits	24
SwissProt Accessions	Q02080	Gene names	MEF2B, XMEF2
Domain Architecture
Description	Myocyte-specific enhancer factor 2B (Serum response factor-like protein 2) (XMEF2) (RSRFR2).

MTMR5_HUMAN
θ value	4.03905 (rank : 498)	NC score	0.033312 (rank : 701)
Query Neighborhood Hits	599	Target Neighborhood Hits	141	Shared Neighborhood Hits	26
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

OSBL6_MOUSE
θ value	4.03905 (rank : 499)	NC score	0.072852 (rank : 504)
Query Neighborhood Hits	599	Target Neighborhood Hits	105	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BXR9, Q8BYW2	Gene names	Osbpl6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

PSL1_HUMAN
θ value	4.03905 (rank : 500)	NC score	0.027553 (rank : 720)
Query Neighborhood Hits	599	Target Neighborhood Hits	650	Shared Neighborhood Hits	66
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

PTK6_HUMAN
θ value	4.03905 (rank : 501)	NC score	0.029154 (rank : 714)
Query Neighborhood Hits	599	Target Neighborhood Hits	1020	Shared Neighborhood Hits	133
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

PYR1_HUMAN
θ value	4.03905 (rank : 502)	NC score	0.006171 (rank : 770)
Query Neighborhood Hits	599	Target Neighborhood Hits	119	Shared Neighborhood Hits	5
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].

SYCP1_MOUSE
θ value	4.03905 (rank : 503)	NC score	0.043111 (rank : 648)
Query Neighborhood Hits	599	Target Neighborhood Hits	1456	Shared Neighborhood Hits	119
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

TCGAP_HUMAN
θ value	4.03905 (rank : 504)	NC score	0.140744 (rank : 398)
Query Neighborhood Hits	599	Target Neighborhood Hits	872	Shared Neighborhood Hits	169
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	4.03905 (rank : 505)	NC score	0.134639 (rank : 405)
Query Neighborhood Hits	599	Target Neighborhood Hits	409	Shared Neighborhood Hits	143
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ARHGG_HUMAN
θ value	5.27518 (rank : 506)	NC score	0.075444 (rank : 498)
Query Neighborhood Hits	599	Target Neighborhood Hits	129	Shared Neighborhood Hits	58
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

BAIP2_HUMAN
θ value	5.27518 (rank : 507)	NC score	0.081251 (rank : 485)
Query Neighborhood Hits	599	Target Neighborhood Hits	192	Shared Neighborhood Hits	73
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	5.27518 (rank : 508)	NC score	0.081149 (rank : 486)
Query Neighborhood Hits	599	Target Neighborhood Hits	185	Shared Neighborhood Hits	70
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BAT2_HUMAN
θ value	5.27518 (rank : 509)	NC score	0.065984 (rank : 525)
Query Neighborhood Hits	599	Target Neighborhood Hits	931	Shared Neighborhood Hits	114
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

CRTC1_HUMAN
θ value	5.27518 (rank : 510)	NC score	0.035198 (rank : 692)
Query Neighborhood Hits	599	Target Neighborhood Hits	319	Shared Neighborhood Hits	63
SwissProt Accessions	Q6UUV9, O75114, Q6Y3A3, Q7LDZ2, Q8IUL3, Q8IZ34, Q8IZL1, Q8N6W3, Q96AI8, Q9H801	Gene names	CRTC1, KIAA0616, MECT1, TORC1, WAMTP1
Domain Architecture	No domain graphic available
Description	CREB-regulated transcription coactivator 1 (Transducer of regulated cAMP response element-binding protein 1) (Transducer of CREB protein 1) (Mucoepidermoid carcinoma translocated protein 1).

EM55_MOUSE
θ value	5.27518 (rank : 511)	NC score	0.058757 (rank : 571)
Query Neighborhood Hits	599	Target Neighborhood Hits	221	Shared Neighborhood Hits	79
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

ES8L3_MOUSE
θ value	5.27518 (rank : 512)	NC score	0.119290 (rank : 422)
Query Neighborhood Hits	599	Target Neighborhood Hits	168	Shared Neighborhood Hits	107
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FGR_MOUSE
θ value	5.27518 (rank : 513)	NC score	0.043476 (rank : 645)
Query Neighborhood Hits	599	Target Neighborhood Hits	1069	Shared Neighborhood Hits	153
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FOG2_MOUSE
θ value	5.27518 (rank : 514)	NC score	-0.003239 (rank : 784)
Query Neighborhood Hits	599	Target Neighborhood Hits	714	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CCH7, Q9Z0F2	Gene names	Zfpm2, Fog2
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM2 (Zinc finger protein multitype 2) (Friend of GATA protein 2) (Friend of GATA-2) (FOG-2) (mFOG-2).

GOGA5_MOUSE
θ value	5.27518 (rank : 515)	NC score	0.037243 (rank : 682)
Query Neighborhood Hits	599	Target Neighborhood Hits	1434	Shared Neighborhood Hits	112
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

GP152_HUMAN
θ value	5.27518 (rank : 516)	NC score	0.007551 (rank : 761)
Query Neighborhood Hits	599	Target Neighborhood Hits	636	Shared Neighborhood Hits	51
SwissProt Accessions	Q8TDT2, Q86SM0	Gene names	GPR152, PGR5
Domain Architecture
Description	Probable G-protein coupled receptor 152 (G-protein coupled receptor PGR5).

HCK_HUMAN
θ value	5.27518 (rank : 517)	NC score	0.037486 (rank : 680)
Query Neighborhood Hits	599	Target Neighborhood Hits	1035	Shared Neighborhood Hits	150
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

KIF5C_HUMAN
θ value	5.27518 (rank : 518)	NC score	0.023791 (rank : 734)
Query Neighborhood Hits	599	Target Neighborhood Hits	974	Shared Neighborhood Hits	88
SwissProt Accessions	O60282, O95079	Gene names	KIF5C, KIAA0531, NKHC2
Domain Architecture	No domain graphic available
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

LAEVR_HUMAN
θ value	5.27518 (rank : 519)	NC score	0.006378 (rank : 767)
Query Neighborhood Hits	599	Target Neighborhood Hits	73	Shared Neighborhood Hits	15
SwissProt Accessions	Q6Q4G3, Q32MR1, Q4G0I9, Q4G0V2, Q86XA3, Q8NBZ2	Gene names	LVRN
Domain Architecture	No domain graphic available
Description	Laeverin (EC 3.4.-.-) (CHL2 antigen).

MILK1_MOUSE
θ value	5.27518 (rank : 520)	NC score	0.036247 (rank : 688)
Query Neighborhood Hits	599	Target Neighborhood Hits	788	Shared Neighborhood Hits	100
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

MYLK_MOUSE
θ value	5.27518 (rank : 521)	NC score	0.004835 (rank : 774)
Query Neighborhood Hits	599	Target Neighborhood Hits	1489	Shared Neighborhood Hits	80
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

NGEF_HUMAN
θ value	5.27518 (rank : 522)	NC score	0.088966 (rank : 468)
Query Neighborhood Hits	599	Target Neighborhood Hits	166	Shared Neighborhood Hits	81
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

OBF1_HUMAN
θ value	5.27518 (rank : 523)	NC score	0.019838 (rank : 738)
Query Neighborhood Hits	599	Target Neighborhood Hits	203	Shared Neighborhood Hits	28
SwissProt Accessions	Q16633, Q14983	Gene names	POU2AF1, OBF1
Domain Architecture	No domain graphic available
Description	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B).

PMYT1_MOUSE
θ value	5.27518 (rank : 524)	NC score	-0.003573 (rank : 785)
Query Neighborhood Hits	599	Target Neighborhood Hits	910	Shared Neighborhood Hits	33
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

PTK6_MOUSE
θ value	5.27518 (rank : 525)	NC score	0.030979 (rank : 707)
Query Neighborhood Hits	599	Target Neighborhood Hits	1026	Shared Neighborhood Hits	131
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

SP5_HUMAN
θ value	5.27518 (rank : 526)	NC score	-0.011164 (rank : 789)
Query Neighborhood Hits	599	Target Neighborhood Hits	832	Shared Neighborhood Hits	25
SwissProt Accessions	Q6BEB4	Gene names	SP5
Domain Architecture	No domain graphic available
Description	Transcription factor Sp5.

ZN307_HUMAN
θ value	5.27518 (rank : 527)	NC score	-0.011293 (rank : 790)
Query Neighborhood Hits	599	Target Neighborhood Hits	750	Shared Neighborhood Hits	13
SwissProt Accessions	Q969J2	Gene names	ZNF307
Domain Architecture
Description	Zinc finger protein 307 (P373c6.1).

AFF1_HUMAN
θ value	6.88961 (rank : 528)	NC score	0.032117 (rank : 704)
Query Neighborhood Hits	599	Target Neighborhood Hits	506	Shared Neighborhood Hits	68
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

AFF4_MOUSE
θ value	6.88961 (rank : 529)	NC score	0.020510 (rank : 737)
Query Neighborhood Hits	599	Target Neighborhood Hits	581	Shared Neighborhood Hits	47
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

ANKR7_HUMAN
θ value	6.88961 (rank : 530)	NC score	0.376330 (rank : 146)
Query Neighborhood Hits	599	Target Neighborhood Hits	286	Shared Neighborhood Hits	227
SwissProt Accessions	Q92527, Q96QN1, Q9UDM3	Gene names	ANKRD7
Domain Architecture
Description	Ankyrin repeat domain-containing protein 7 (Testis-specific protein TSA806).

ANKS6_MOUSE
θ value	6.88961 (rank : 531)	NC score	0.366176 (rank : 170)
Query Neighborhood Hits	599	Target Neighborhood Hits	435	Shared Neighborhood Hits	245
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

ATS2_MOUSE
θ value	6.88961 (rank : 532)	NC score	-0.001183 (rank : 781)
Query Neighborhood Hits	599	Target Neighborhood Hits	179	Shared Neighborhood Hits	10
SwissProt Accessions	Q8C9W3	Gene names	Adamts2
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

BAT2_MOUSE
θ value	6.88961 (rank : 533)	NC score	0.055350 (rank : 591)
Query Neighborhood Hits	599	Target Neighborhood Hits	947	Shared Neighborhood Hits	112
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

BSN_HUMAN
θ value	6.88961 (rank : 534)	NC score	0.062341 (rank : 543)
Query Neighborhood Hits	599	Target Neighborhood Hits	1537	Shared Neighborhood Hits	173
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CASP_HUMAN
θ value	6.88961 (rank : 535)	NC score	0.029590 (rank : 713)
Query Neighborhood Hits	599	Target Neighborhood Hits	1131	Shared Neighborhood Hits	97
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CDN2C_HUMAN
θ value	6.88961 (rank : 536)	NC score	0.366465 (rank : 169)
Query Neighborhood Hits	599	Target Neighborhood Hits	262	Shared Neighborhood Hits	221
SwissProt Accessions	P42773, Q8TB83	Gene names	CDKN2C, CDKN6
Domain Architecture
Description	Cyclin-dependent kinase 6 inhibitor (p18-INK6) (Cyclin-dependent kinase 4 inhibitor C) (p18-INK4c).

CP250_MOUSE
θ value	6.88961 (rank : 537)	NC score	0.041117 (rank : 657)
Query Neighborhood Hits	599	Target Neighborhood Hits	1583	Shared Neighborhood Hits	120
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

GLIS3_MOUSE
θ value	6.88961 (rank : 538)	NC score	-0.010302 (rank : 788)
Query Neighborhood Hits	599	Target Neighborhood Hits	861	Shared Neighborhood Hits	31
SwissProt Accessions	Q6XP49, Q8BI60	Gene names	Glis3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS3 (GLI-similar 3).

IKBA_MOUSE
θ value	6.88961 (rank : 539)	NC score	0.355511 (rank : 184)
Query Neighborhood Hits	599	Target Neighborhood Hits	283	Shared Neighborhood Hits	226
SwissProt Accessions	Q9Z1E3, Q80ZX5	Gene names	Nfkbia, Ikba
Domain Architecture	No domain graphic available
Description	NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkappaBalpha) (IKB- alpha).

KIF5C_MOUSE
θ value	6.88961 (rank : 540)	NC score	0.024147 (rank : 731)
Query Neighborhood Hits	599	Target Neighborhood Hits	1040	Shared Neighborhood Hits	93
SwissProt Accessions	P28738, Q9Z2F8	Gene names	Kif5c, Nkhc2
Domain Architecture
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

LATS2_HUMAN
θ value	6.88961 (rank : 541)	NC score	-0.001294 (rank : 782)
Query Neighborhood Hits	599	Target Neighborhood Hits	884	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

M3K11_HUMAN
θ value	6.88961 (rank : 542)	NC score	0.051219 (rank : 618)
Query Neighborhood Hits	599	Target Neighborhood Hits	1136	Shared Neighborhood Hits	183
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

MUC5B_HUMAN
θ value	6.88961 (rank : 543)	NC score	0.032545 (rank : 702)
Query Neighborhood Hits	599	Target Neighborhood Hits	1020	Shared Neighborhood Hits	78
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

MYH9_HUMAN
θ value	6.88961 (rank : 544)	NC score	0.039102 (rank : 669)
Query Neighborhood Hits	599	Target Neighborhood Hits	1762	Shared Neighborhood Hits	134
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

MYH9_MOUSE
θ value	6.88961 (rank : 545)	NC score	0.039825 (rank : 665)
Query Neighborhood Hits	599	Target Neighborhood Hits	1829	Shared Neighborhood Hits	140
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

NEMO_HUMAN
θ value	6.88961 (rank : 546)	NC score	0.024009 (rank : 732)
Query Neighborhood Hits	599	Target Neighborhood Hits	820	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y6K9	Gene names	IKBKG, FIP3, NEMO
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (FIP-3).

NOS3_HUMAN
θ value	6.88961 (rank : 547)	NC score	0.006517 (rank : 766)
Query Neighborhood Hits	599	Target Neighborhood Hits	59	Shared Neighborhood Hits	15
SwissProt Accessions	P29474, Q13662, Q14251, Q14434	Gene names	NOS3
Domain Architecture
Description	Nitric-oxide synthase, endothelial (EC 1.14.13.39) (EC-NOS) (NOS type III) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS).

NRX2A_HUMAN
θ value	6.88961 (rank : 548)	NC score	0.014212 (rank : 749)
Query Neighborhood Hits	599	Target Neighborhood Hits	614	Shared Neighborhood Hits	51
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

NRX2B_HUMAN
θ value	6.88961 (rank : 549)	NC score	0.016546 (rank : 746)
Query Neighborhood Hits	599	Target Neighborhood Hits	481	Shared Neighborhood Hits	45
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

OGFR_HUMAN
θ value	6.88961 (rank : 550)	NC score	0.056592 (rank : 581)
Query Neighborhood Hits	599	Target Neighborhood Hits	1582	Shared Neighborhood Hits	132
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

PKHA1_HUMAN
θ value	6.88961 (rank : 551)	NC score	0.108572 (rank : 438)
Query Neighborhood Hits	599	Target Neighborhood Hits	127	Shared Neighborhood Hits	41
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	6.88961 (rank : 552)	NC score	0.102823 (rank : 446)
Query Neighborhood Hits	599	Target Neighborhood Hits	120	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

RASA1_HUMAN
θ value	6.88961 (rank : 553)	NC score	0.040864 (rank : 661)
Query Neighborhood Hits	599	Target Neighborhood Hits	258	Shared Neighborhood Hits	57
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RBM4_MOUSE
θ value	6.88961 (rank : 554)	NC score	0.005137 (rank : 773)
Query Neighborhood Hits	599	Target Neighborhood Hits	223	Shared Neighborhood Hits	5
SwissProt Accessions	Q8C7Q4, O08752, Q8BN66	Gene names	Rbm4, Rbm4a
Domain Architecture	No domain graphic available
Description	RNA-binding protein 4 (RNA-binding motif protein 4) (RNA-binding motif protein 4a) (Lark homolog) (mLark).

RTP3_MOUSE
θ value	6.88961 (rank : 555)	NC score	0.037939 (rank : 675)
Query Neighborhood Hits	599	Target Neighborhood Hits	374	Shared Neighborhood Hits	58
SwissProt Accessions	Q5QGU6, Q8VDC2	Gene names	Rtp3, Tmem7
Domain Architecture	No domain graphic available
Description	Receptor-transporting protein 3 (Transmembrane protein 7).

SNPC4_HUMAN
θ value	6.88961 (rank : 556)	NC score	0.042818 (rank : 651)
Query Neighborhood Hits	599	Target Neighborhood Hits	589	Shared Neighborhood Hits	79
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

SRC_HUMAN
θ value	6.88961 (rank : 557)	NC score	0.043403 (rank : 646)
Query Neighborhood Hits	599	Target Neighborhood Hits	1058	Shared Neighborhood Hits	154
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

TAF6L_MOUSE
θ value	6.88961 (rank : 558)	NC score	0.017289 (rank : 745)
Query Neighborhood Hits	599	Target Neighborhood Hits	146	Shared Neighborhood Hits	22
SwissProt Accessions	Q8R2K4, Q8C5T2	Gene names	Taf6l, Paf65a
Domain Architecture
Description	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (PCAF-associated factor 65 alpha) (PAF65- alpha).

TRIPB_HUMAN
θ value	6.88961 (rank : 559)	NC score	0.037730 (rank : 677)
Query Neighborhood Hits	599	Target Neighborhood Hits	1587	Shared Neighborhood Hits	119
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

TTC16_MOUSE
θ value	6.88961 (rank : 560)	NC score	0.009259 (rank : 756)
Query Neighborhood Hits	599	Target Neighborhood Hits	98	Shared Neighborhood Hits	7
SwissProt Accessions	Q8C1F5	Gene names	Ttc16
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 16 (TPR repeat protein 16).

ACADV_HUMAN
θ value	8.99809 (rank : 561)	NC score	0.001017 (rank : 779)
Query Neighborhood Hits	599	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	P49748, O76056, Q8WUL0	Gene names	ACADVL, VLCAD
Domain Architecture
Description	Very-long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor (EC 1.3.99.-) (VLCAD).

ANR16_HUMAN
θ value	8.99809 (rank : 562)	NC score	0.369698 (rank : 161)
Query Neighborhood Hits	599	Target Neighborhood Hits	286	Shared Neighborhood Hits	228
SwissProt Accessions	Q6P6B7, Q9NT01	Gene names	ANKRD16
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 16.

ANR33_MOUSE
θ value	8.99809 (rank : 563)	NC score	0.311402 (rank : 225)
Query Neighborhood Hits	599	Target Neighborhood Hits	225	Shared Neighborhood Hits	195
SwissProt Accessions	Q8BXP5, Q8BXP4, Q8R1Z1	Gene names	Ankrd33
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

CAC1B_MOUSE
θ value	8.99809 (rank : 564)	NC score	0.006258 (rank : 768)
Query Neighborhood Hits	599	Target Neighborhood Hits	351	Shared Neighborhood Hits	37
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CASL_MOUSE
θ value	8.99809 (rank : 565)	NC score	0.136373 (rank : 403)
Query Neighborhood Hits	599	Target Neighborhood Hits	225	Shared Neighborhood Hits	133
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CG026_MOUSE
θ value	8.99809 (rank : 566)	NC score	0.006257 (rank : 769)
Query Neighborhood Hits	599	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BGA7, Q3T9D0, Q8BN55	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C7orf26 homolog.

CNCG_MOUSE
θ value	8.99809 (rank : 567)	NC score	0.006764 (rank : 763)
Query Neighborhood Hits	599	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	P61249, Q9D1Y6, Q9EP63	Gene names	Pde6h
Domain Architecture
Description	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase gamma-subunit (EC 3.1.4.17) (GMP-PDE gamma).

CP250_HUMAN
θ value	8.99809 (rank : 568)	NC score	0.034965 (rank : 694)
Query Neighborhood Hits	599	Target Neighborhood Hits	1805	Shared Neighborhood Hits	121
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

CT194_HUMAN
θ value	8.99809 (rank : 569)	NC score	0.006573 (rank : 765)
Query Neighborhood Hits	599	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q5TEA3, Q66K86, Q6P2R9, Q9UFX9	Gene names	C20orf194
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf194.

DZIP3_MOUSE
θ value	8.99809 (rank : 570)	NC score	0.011791 (rank : 751)
Query Neighborhood Hits	599	Target Neighborhood Hits	414	Shared Neighborhood Hits	42
SwissProt Accessions	Q7TPV2, Q80TU4, Q8BYK7	Gene names	Dzip3, Kiaa0675
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3 homolog).

EP15R_MOUSE
θ value	8.99809 (rank : 571)	NC score	0.044065 (rank : 643)
Query Neighborhood Hits	599	Target Neighborhood Hits	1135	Shared Neighborhood Hits	101
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

EPN3_MOUSE
θ value	8.99809 (rank : 572)	NC score	0.018003 (rank : 742)
Query Neighborhood Hits	599	Target Neighborhood Hits	312	Shared Neighborhood Hits	44
SwissProt Accessions	Q91W69, Q9CV55	Gene names	Epn3
Domain Architecture
Description	Epsin-3 (EPS-15-interacting protein 3).

ETV4_HUMAN
θ value	8.99809 (rank : 573)	NC score	0.000835 (rank : 780)
Query Neighborhood Hits	599	Target Neighborhood Hits	100	Shared Neighborhood Hits	9
SwissProt Accessions	P43268, Q96AW9	Gene names	ETV4, E1AF
Domain Architecture	No domain graphic available
Description	ETS translocation variant 4 (Adenovirus E1A enhancer-binding protein) (E1A-F).

EXTL1_MOUSE
θ value	8.99809 (rank : 574)	NC score	0.002679 (rank : 778)
Query Neighborhood Hits	599	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JKV7	Gene names	Extl1
Domain Architecture
Description	Exostosin-like 1 (EC 2.4.1.224) (Glucuronosyl-N-acetylglucosaminyl- proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Exostosin-L) (Multiple exostosis-like protein).

FA47B_HUMAN
θ value	8.99809 (rank : 575)	NC score	0.037558 (rank : 679)
Query Neighborhood Hits	599	Target Neighborhood Hits	431	Shared Neighborhood Hits	51
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

GOGA3_HUMAN
θ value	8.99809 (rank : 576)	NC score	0.033400 (rank : 700)
Query Neighborhood Hits	599	Target Neighborhood Hits	1317	Shared Neighborhood Hits	105
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

K0310_HUMAN
θ value	8.99809 (rank : 577)	NC score	0.037893 (rank : 676)
Query Neighborhood Hits	599	Target Neighborhood Hits	420	Shared Neighborhood Hits	66
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

KNTC1_HUMAN
θ value	8.99809 (rank : 578)	NC score	0.005722 (rank : 771)
Query Neighborhood Hits	599	Target Neighborhood Hits	67	Shared Neighborhood Hits	10
SwissProt Accessions	P50748	Gene names	KNTC1, KIAA0166
Domain Architecture	No domain graphic available
Description	Kinetochore-associated protein 1 (Rough deal homolog) (hRod) (HsROD) (Rod).

MAP2_HUMAN
θ value	8.99809 (rank : 579)	NC score	0.019161 (rank : 739)
Query Neighborhood Hits	599	Target Neighborhood Hits	348	Shared Neighborhood Hits	42
SwissProt Accessions	P11137, Q99975, Q99976	Gene names	MAP2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2) (MAP-2).

MINT_MOUSE
θ value	8.99809 (rank : 580)	NC score	0.034599 (rank : 696)
Query Neighborhood Hits	599	Target Neighborhood Hits	1514	Shared Neighborhood Hits	130
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

MPP6_HUMAN
θ value	8.99809 (rank : 581)	NC score	0.039456 (rank : 667)
Query Neighborhood Hits	599	Target Neighborhood Hits	180	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
θ value	8.99809 (rank : 582)	NC score	0.040085 (rank : 663)
Query Neighborhood Hits	599	Target Neighborhood Hits	187	Shared Neighborhood Hits	60
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

MTSS1_HUMAN
θ value	8.99809 (rank : 583)	NC score	0.023172 (rank : 735)
Query Neighborhood Hits	599	Target Neighborhood Hits	504	Shared Neighborhood Hits	69
SwissProt Accessions	O43312, Q8TCA2, Q96RX2	Gene names	MTSS1, KIAA0429, MIM
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein) (Metastasis suppressor YGL-1).

MTSS1_MOUSE
θ value	8.99809 (rank : 584)	NC score	0.029945 (rank : 711)
Query Neighborhood Hits	599	Target Neighborhood Hits	592	Shared Neighborhood Hits	74
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

NOS3_MOUSE
θ value	8.99809 (rank : 585)	NC score	0.005373 (rank : 772)
Query Neighborhood Hits	599	Target Neighborhood Hits	63	Shared Neighborhood Hits	12
SwissProt Accessions	P70313, O55056	Gene names	Nos3, Ecnos
Domain Architecture
Description	Nitric-oxide synthase, endothelial (EC 1.14.13.39) (EC-NOS) (NOS type III) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS).

OSBL9_HUMAN
θ value	8.99809 (rank : 586)	NC score	0.069028 (rank : 508)
Query Neighborhood Hits	599	Target Neighborhood Hits	138	Shared Neighborhood Hits	43
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

PDLI7_HUMAN
θ value	8.99809 (rank : 587)	NC score	0.008057 (rank : 759)
Query Neighborhood Hits	599	Target Neighborhood Hits	547	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PF21A_HUMAN
θ value	8.99809 (rank : 588)	NC score	0.004181 (rank : 776)
Query Neighborhood Hits	599	Target Neighborhood Hits	303	Shared Neighborhood Hits	24
SwissProt Accessions	Q96BD5, Q6AWA2, Q9C0G7, Q9H8V9, Q9HAK6, Q9NZE9	Gene names	PHF21A, BHC80, KIAA1696
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (BHC80a).

RENT2_HUMAN
θ value	8.99809 (rank : 589)	NC score	0.030005 (rank : 709)
Query Neighborhood Hits	599	Target Neighborhood Hits	618	Shared Neighborhood Hits	64
SwissProt Accessions	Q9HAU5, Q8N8U1, Q9H1J2, Q9NWL1, Q9P2D9, Q9Y4M9	Gene names	UPF2, KIAA1408, RENT2
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 2 (Nonsense mRNA reducing factor 2) (Up-frameshift suppressor 2 homolog) (hUpf2).

RGS3_HUMAN
θ value	8.99809 (rank : 590)	NC score	0.034504 (rank : 698)
Query Neighborhood Hits	599	Target Neighborhood Hits	1375	Shared Neighborhood Hits	106
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

RUSC2_HUMAN
θ value	8.99809 (rank : 591)	NC score	0.066653 (rank : 520)
Query Neighborhood Hits	599	Target Neighborhood Hits	205	Shared Neighborhood Hits	79
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

S25BP_HUMAN
θ value	8.99809 (rank : 592)	NC score	0.017416 (rank : 744)
Query Neighborhood Hits	599	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	O95295	Gene names	SNAPAP, SNAP25BP
Domain Architecture	No domain graphic available
Description	SNARE-associated protein Snapin (Synaptosomal-associated protein 25- binding protein) (SNAP-associated protein).

S25BP_MOUSE
θ value	8.99809 (rank : 593)	NC score	0.017422 (rank : 743)
Query Neighborhood Hits	599	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z266, Q3U8V4, Q922V7	Gene names	Snapap, Snap25bp
Domain Architecture	No domain graphic available
Description	SNARE-associated protein Snapin (Synaptosomal-associated protein 25- binding protein) (SNAP-associated protein).

SPTA1_MOUSE
θ value	8.99809 (rank : 594)	NC score	0.086833 (rank : 472)
Query Neighborhood Hits	599	Target Neighborhood Hits	675	Shared Neighborhood Hits	168
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SRGP2_MOUSE
θ value	8.99809 (rank : 595)	NC score	0.118956 (rank : 423)
Query Neighborhood Hits	599	Target Neighborhood Hits	324	Shared Neighborhood Hits	147
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SWP70_HUMAN
θ value	8.99809 (rank : 596)	NC score	0.059966 (rank : 566)
Query Neighborhood Hits	599	Target Neighborhood Hits	973	Shared Neighborhood Hits	114
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
θ value	8.99809 (rank : 597)	NC score	0.058687 (rank : 572)
Query Neighborhood Hits	599	Target Neighborhood Hits	1097	Shared Neighborhood Hits	118
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

TIAM1_MOUSE
θ value	8.99809 (rank : 598)	NC score	0.068319 (rank : 511)
Query Neighborhood Hits	599	Target Neighborhood Hits	205	Shared Neighborhood Hits	37
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ZC3H6_MOUSE
θ value	8.99809 (rank : 599)	NC score	0.007261 (rank : 762)
Query Neighborhood Hits	599	Target Neighborhood Hits	239	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BYK8, Q80UK3, Q8C1H1, Q9D604	Gene names	Zc3h6, Zc3hdc6
Domain Architecture
Description	Zinc finger CCCH domain-containing protein 6.

3BP1_HUMAN
θ value	θ > 10 (rank : 600)	NC score	0.078960 (rank : 489)
Query Neighborhood Hits	599	Target Neighborhood Hits	376	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

3BP1_MOUSE
θ value	θ > 10 (rank : 601)	NC score	0.063892 (rank : 534)
Query Neighborhood Hits	599	Target Neighborhood Hits	238	Shared Neighborhood Hits	75
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

ABI3_HUMAN
θ value	θ > 10 (rank : 602)	NC score	0.185228 (rank : 365)
Query Neighborhood Hits	599	Target Neighborhood Hits	227	Shared Neighborhood Hits	134
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 603)	NC score	0.172284 (rank : 378)
Query Neighborhood Hits	599	Target Neighborhood Hits	227	Shared Neighborhood Hits	130
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABR_HUMAN
θ value	θ > 10 (rank : 604)	NC score	0.076311 (rank : 496)
Query Neighborhood Hits	599	Target Neighborhood Hits	166	Shared Neighborhood Hits	41
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ABTB1_HUMAN
θ value	θ > 10 (rank : 605)	NC score	0.101750 (rank : 448)
Query Neighborhood Hits	599	Target Neighborhood Hits	325	Shared Neighborhood Hits	141
SwissProt Accessions	Q969K4, Q6ZNU9, Q71MF1, Q96S62, Q96S63	Gene names	ABTB1, BPOZ
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 1 (Elongation factor 1A-binding protein).

ABTB1_MOUSE
θ value	θ > 10 (rank : 606)	NC score	0.115615 (rank : 430)
Query Neighborhood Hits	599	Target Neighborhood Hits	349	Shared Neighborhood Hits	151
SwissProt Accessions	Q99LJ2, Q8C2K7, Q91XU4	Gene names	Abtb1, Bpoz
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 1.

ABTB2_HUMAN
θ value	θ > 10 (rank : 607)	NC score	0.231413 (rank : 299)
Query Neighborhood Hits	599	Target Neighborhood Hits	391	Shared Neighborhood Hits	205
SwissProt Accessions	Q8N961, Q6MZW4, Q8NB44	Gene names	ABTB2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

ABTB2_MOUSE
θ value	θ > 10 (rank : 608)	NC score	0.222158 (rank : 311)
Query Neighborhood Hits	599	Target Neighborhood Hits	414	Shared Neighborhood Hits	203
SwissProt Accessions	Q7TQI7	Gene names	Abtb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

AN13A_HUMAN
θ value	θ > 10 (rank : 609)	NC score	0.199572 (rank : 339)
Query Neighborhood Hits	599	Target Neighborhood Hits	243	Shared Neighborhood Hits	191
SwissProt Accessions	Q8IZ07, O60736	Gene names	ANKRD13A, ANKRD13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13A (Protein KE03).

AN13A_MOUSE
θ value	θ > 10 (rank : 610)	NC score	0.190387 (rank : 358)
Query Neighborhood Hits	599	Target Neighborhood Hits	226	Shared Neighborhood Hits	187
SwissProt Accessions	Q80UP5, Q2VPQ7, Q6P7F2	Gene names	Ankrd13a, Ankrd13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13A.

AN13B_HUMAN
θ value	θ > 10 (rank : 611)	NC score	0.251675 (rank : 275)
Query Neighborhood Hits	599	Target Neighborhood Hits	265	Shared Neighborhood Hits	218
SwissProt Accessions	Q86YJ7, Q8N7S9	Gene names	ANKRD13B
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13B.

AN13B_MOUSE
θ value	θ > 10 (rank : 612)	NC score	0.252472 (rank : 274)
Query Neighborhood Hits	599	Target Neighborhood Hits	276	Shared Neighborhood Hits	220
SwissProt Accessions	Q5F259, Q6IR40	Gene names	Ankrd13b
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13B.

ANKF1_HUMAN
θ value	θ > 10 (rank : 613)	NC score	0.059051 (rank : 570)
Query Neighborhood Hits	599	Target Neighborhood Hits	126	Shared Neighborhood Hits	64
SwissProt Accessions	Q8N957	Gene names	ANKFN1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and fibronectin type-III domain-containing protein 1.

ANKY1_HUMAN
θ value	θ > 10 (rank : 614)	NC score	0.210620 (rank : 321)
Query Neighborhood Hits	599	Target Neighborhood Hits	248	Shared Neighborhood Hits	176
SwissProt Accessions	Q9P2S6, Q8IYX5, Q8NDK5, Q9NX10	Gene names	ANKMY1, TSAL1, ZMYND13
Domain Architecture
Description	Ankyrin repeat and MYND domain-containing protein 1 (Testis-specific ankyrin-like protein 1) (Zinc-finger MYND domain-containing protein 13).

ANKY2_HUMAN
θ value	θ > 10 (rank : 615)	NC score	0.320799 (rank : 219)
Query Neighborhood Hits	599	Target Neighborhood Hits	306	Shared Neighborhood Hits	217
SwissProt Accessions	Q8IV38, Q96BL3	Gene names	ANKMY2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and MYND domain-containing protein 2.

ANKY2_MOUSE
θ value	θ > 10 (rank : 616)	NC score	0.305127 (rank : 228)
Query Neighborhood Hits	599	Target Neighborhood Hits	316	Shared Neighborhood Hits	216
SwissProt Accessions	Q3TPE9, Q8BK14, Q8BYW5, Q8R3N4, Q921J1	Gene names	Ankmy2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and MYND domain-containing protein 2.

ANKZ1_HUMAN
θ value	θ > 10 (rank : 617)	NC score	0.136026 (rank : 404)
Query Neighborhood Hits	599	Target Neighborhood Hits	236	Shared Neighborhood Hits	148
SwissProt Accessions	Q9H8Y5, Q9NVZ4	Gene names	ANKZF1, ZNF744
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1 (Zinc finger protein 744).

ANKZ1_MOUSE
θ value	θ > 10 (rank : 618)	NC score	0.145210 (rank : 394)
Query Neighborhood Hits	599	Target Neighborhood Hits	208	Shared Neighborhood Hits	137
SwissProt Accessions	Q80UU1, Q9CZF5	Gene names	Ankzf1, D1Ertd161e
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1.

ANM2_HUMAN
θ value	θ > 10 (rank : 619)	NC score	0.087397 (rank : 469)
Query Neighborhood Hits	599	Target Neighborhood Hits	175	Shared Neighborhood Hits	116
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 620)	NC score	0.083650 (rank : 479)
Query Neighborhood Hits	599	Target Neighborhood Hits	175	Shared Neighborhood Hits	111
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANR25_HUMAN
θ value	θ > 10 (rank : 621)	NC score	0.288954 (rank : 236)
Query Neighborhood Hits	599	Target Neighborhood Hits	350	Shared Neighborhood Hits	222
SwissProt Accessions	Q63ZY3, Q3KQZ3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210	Gene names	ANKRD25, KIAA1518, SIP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25 (SRC-1-interacting protein) (SRC1-interacting protein).

ANR25_MOUSE
θ value	θ > 10 (rank : 622)	NC score	0.278867 (rank : 240)
Query Neighborhood Hits	599	Target Neighborhood Hits	398	Shared Neighborhood Hits	235
SwissProt Accessions	Q8BX02, Q8BLD5, Q91Z35	Gene names	Ankrd25
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25.

ANR33_HUMAN
θ value	θ > 10 (rank : 623)	NC score	0.311594 (rank : 224)
Query Neighborhood Hits	599	Target Neighborhood Hits	215	Shared Neighborhood Hits	189
SwissProt Accessions	Q7Z3H0, Q5K619, Q5K621, Q5K622, Q5K623, Q5K624, Q6ZUN0	Gene names	ANKRD33, C12orf7
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

ANR43_HUMAN
θ value	θ > 10 (rank : 624)	NC score	0.265400 (rank : 257)
Query Neighborhood Hits	599	Target Neighborhood Hits	209	Shared Neighborhood Hits	176
SwissProt Accessions	Q2M3V2, Q8NAE7	Gene names	ANKRD43
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 43.

ANR43_MOUSE
θ value	θ > 10 (rank : 625)	NC score	0.262863 (rank : 262)
Query Neighborhood Hits	599	Target Neighborhood Hits	214	Shared Neighborhood Hits	181
SwissProt Accessions	Q8BLS7	Gene names	Ankrd43
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 43.

ANR47_HUMAN
θ value	θ > 10 (rank : 626)	NC score	0.303821 (rank : 229)
Query Neighborhood Hits	599	Target Neighborhood Hits	369	Shared Neighborhood Hits	229
SwissProt Accessions	Q6NY19, Q6NZI1, Q6ZQR3, Q8IUV2	Gene names	ANKRD47
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

ANR47_MOUSE
θ value	θ > 10 (rank : 627)	NC score	0.315505 (rank : 221)
Query Neighborhood Hits	599	Target Neighborhood Hits	350	Shared Neighborhood Hits	229
SwissProt Accessions	Q9Z1P7	Gene names	Ankrd47, D17Ertd288e, Ng28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

ARHG3_HUMAN
θ value	θ > 10 (rank : 628)	NC score	0.063079 (rank : 539)
Query Neighborhood Hits	599	Target Neighborhood Hits	82	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 629)	NC score	0.062984 (rank : 540)
Query Neighborhood Hits	599	Target Neighborhood Hits	85	Shared Neighborhood Hits	26
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG8_HUMAN
θ value	θ > 10 (rank : 630)	NC score	0.058151 (rank : 575)
Query Neighborhood Hits	599	Target Neighborhood Hits	85	Shared Neighborhood Hits	26
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 631)	NC score	0.064048 (rank : 531)
Query Neighborhood Hits	599	Target Neighborhood Hits	79	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGA_HUMAN
θ value	θ > 10 (rank : 632)	NC score	0.053831 (rank : 601)
Query Neighborhood Hits	599	Target Neighborhood Hits	187	Shared Neighborhood Hits	35
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 633)	NC score	0.055769 (rank : 586)
Query Neighborhood Hits	599	Target Neighborhood Hits	125	Shared Neighborhood Hits	33
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGF_HUMAN
θ value	θ > 10 (rank : 634)	NC score	0.064035 (rank : 532)
Query Neighborhood Hits	599	Target Neighborhood Hits	214	Shared Neighborhood Hits	71
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ASB12_HUMAN
θ value	θ > 10 (rank : 635)	NC score	0.347992 (rank : 193)
Query Neighborhood Hits	599	Target Neighborhood Hits	263	Shared Neighborhood Hits	218
SwissProt Accessions	Q8WXK4, Q52LK4, Q6ISF9	Gene names	ASB12
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 12 (ASB-12).

ASB12_MOUSE
θ value	θ > 10 (rank : 636)	NC score	0.347016 (rank : 194)
Query Neighborhood Hits	599	Target Neighborhood Hits	261	Shared Neighborhood Hits	218
SwissProt Accessions	Q9D738	Gene names	Asb12
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 12 (ASB-12).

ASB14_HUMAN
θ value	θ > 10 (rank : 637)	NC score	0.200848 (rank : 334)
Query Neighborhood Hits	599	Target Neighborhood Hits	187	Shared Neighborhood Hits	155
SwissProt Accessions	Q8WXK2	Gene names	ASB14
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 14 (ASB-14).

ASB6_HUMAN
θ value	θ > 10 (rank : 638)	NC score	0.307763 (rank : 227)
Query Neighborhood Hits	599	Target Neighborhood Hits	256	Shared Neighborhood Hits	205
SwissProt Accessions	Q9NWX5	Gene names	ASB6
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 6 (ASB-6).

ASB6_MOUSE
θ value	θ > 10 (rank : 639)	NC score	0.301852 (rank : 230)
Query Neighborhood Hits	599	Target Neighborhood Hits	264	Shared Neighborhood Hits	207
SwissProt Accessions	Q91ZU1, Q8VEC6	Gene names	Asb6
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 6 (ASB-6).

ASB9_MOUSE
θ value	θ > 10 (rank : 640)	NC score	0.356892 (rank : 183)
Query Neighborhood Hits	599	Target Neighborhood Hits	257	Shared Neighborhood Hits	211
SwissProt Accessions	Q91ZT8, Q9DAF7	Gene names	Asb9
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 9 (ASB-9).

BASP_MOUSE
θ value	θ > 10 (rank : 641)	NC score	0.050266 (rank : 626)
Query Neighborhood Hits	599	Target Neighborhood Hits	260	Shared Neighborhood Hits	45
SwissProt Accessions	Q91XV3	Gene names	Basp1, Nap22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

BAT4_HUMAN
θ value	θ > 10 (rank : 642)	NC score	0.112948 (rank : 432)
Query Neighborhood Hits	599	Target Neighborhood Hits	157	Shared Neighborhood Hits	97
SwissProt Accessions	O95872	Gene names	BAT4, G5
Domain Architecture
Description	Protein BAT4 (HLA-B-associated transcript 4) (G5 protein).

BAT4_MOUSE
θ value	θ > 10 (rank : 643)	NC score	0.111531 (rank : 434)
Query Neighborhood Hits	599	Target Neighborhood Hits	171	Shared Neighborhood Hits	109
SwissProt Accessions	Q61858, Q9R065	Gene names	Bat4, Bat-4, G5
Domain Architecture
Description	Protein BAT4 (HLA-B-associated transcript 4) (G5 protein).

BCR_HUMAN
θ value	θ > 10 (rank : 644)	NC score	0.085010 (rank : 477)
Query Neighborhood Hits	599	Target Neighborhood Hits	204	Shared Neighborhood Hits	51
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

CD2A1_HUMAN
θ value	θ > 10 (rank : 645)	NC score	0.265384 (rank : 258)
Query Neighborhood Hits	599	Target Neighborhood Hits	196	Shared Neighborhood Hits	169
SwissProt Accessions	P42771, O95440, Q15191, Q5VVJ5, Q96B52, Q9NP05	Gene names	CDKN2A, CDKN2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4) (p16-INK4a) (p16INK4A) (Multiple tumor suppressor 1) (MTS1).

CD2A1_MOUSE
θ value	θ > 10 (rank : 646)	NC score	0.295701 (rank : 232)
Query Neighborhood Hits	599	Target Neighborhood Hits	206	Shared Neighborhood Hits	177
SwissProt Accessions	P51480, O89088, P97510, P97937, Q6PEA2, Q78E39, Q78E57, Q792X7, Q9QWH6, Q9QWH7, Q9QWH8	Gene names	Cdkn2a, P16ink4a
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 2A, isoforms 1/2 (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4) (p16-INK4a).

CDN2B_HUMAN
θ value	θ > 10 (rank : 647)	NC score	0.257706 (rank : 267)
Query Neighborhood Hits	599	Target Neighborhood Hits	196	Shared Neighborhood Hits	171
SwissProt Accessions	P42772, Q6FI09	Gene names	CDKN2B, MTS2
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b) (p15INK4B) (Multiple tumor suppressor 2) (MTS2).

CDN2B_MOUSE
θ value	θ > 10 (rank : 648)	NC score	0.265039 (rank : 259)
Query Neighborhood Hits	599	Target Neighborhood Hits	201	Shared Neighborhood Hits	174
SwissProt Accessions	P55271	Gene names	Cdkn2b
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b).

CDN2C_MOUSE
θ value	θ > 10 (rank : 649)	NC score	0.365282 (rank : 173)
Query Neighborhood Hits	599	Target Neighborhood Hits	270	Shared Neighborhood Hits	222
SwissProt Accessions	Q60772	Gene names	Cdkn2c
Domain Architecture
Description	Cyclin-dependent kinase 6 inhibitor (p18-INK6) (Cyclin-dependent kinase 4 inhibitor C) (p18-INK4c).

CDN2D_HUMAN
θ value	θ > 10 (rank : 650)	NC score	0.369246 (rank : 163)
Query Neighborhood Hits	599	Target Neighborhood Hits	268	Shared Neighborhood Hits	218
SwissProt Accessions	P55273, Q13102, Q6FGE9	Gene names	CDKN2D
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

CDN2D_MOUSE
θ value	θ > 10 (rank : 651)	NC score	0.359427 (rank : 178)
Query Neighborhood Hits	599	Target Neighborhood Hits	267	Shared Neighborhood Hits	217
SwissProt Accessions	Q60773, Q60794	Gene names	Cdkn2d
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

CHIN_HUMAN
θ value	θ > 10 (rank : 652)	NC score	0.060503 (rank : 561)
Query Neighborhood Hits	599	Target Neighborhood Hits	227	Shared Neighborhood Hits	40
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 653)	NC score	0.061256 (rank : 553)
Query Neighborhood Hits	599	Target Neighborhood Hits	229	Shared Neighborhood Hits	43
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 654)	NC score	0.060258 (rank : 562)
Query Neighborhood Hits	599	Target Neighborhood Hits	220	Shared Neighborhood Hits	40
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_MOUSE
θ value	θ > 10 (rank : 655)	NC score	0.055628 (rank : 588)
Query Neighborhood Hits	599	Target Neighborhood Hits	130	Shared Neighborhood Hits	21
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CIP4_HUMAN
θ value	θ > 10 (rank : 656)	NC score	0.057163 (rank : 578)
Query Neighborhood Hits	599	Target Neighborhood Hits	374	Shared Neighborhood Hits	80
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CJ078_MOUSE
θ value	θ > 10 (rank : 657)	NC score	0.053512 (rank : 604)
Query Neighborhood Hits	599	Target Neighborhood Hits	559	Shared Neighborhood Hits	88
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

CLR59_HUMAN
θ value	θ > 10 (rank : 658)	NC score	0.117753 (rank : 427)
Query Neighborhood Hits	599	Target Neighborhood Hits	163	Shared Neighborhood Hits	131
SwissProt Accessions	Q96DZ5, Q8WWL1, Q96C99, Q9UFT7	Gene names	CLIPR59
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 170-related 59 kDa protein (CLIPR-59) (CLIP-170-related 59 kDa protein).

CMTA1_HUMAN
θ value	θ > 10 (rank : 659)	NC score	0.077274 (rank : 494)
Query Neighborhood Hits	599	Target Neighborhood Hits	217	Shared Neighborhood Hits	98
SwissProt Accessions	Q9Y6Y1, Q5VUE1	Gene names	CAMTA1, KIAA0833
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 1.

CMTA2_HUMAN
θ value	θ > 10 (rank : 660)	NC score	0.063525 (rank : 537)
Query Neighborhood Hits	599	Target Neighborhood Hits	199	Shared Neighborhood Hits	101
SwissProt Accessions	O94983, Q7Z6M8, Q8N3V0, Q8NDG4, Q96G17	Gene names	CAMTA2, KIAA0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

CMTA2_MOUSE
θ value	θ > 10 (rank : 661)	NC score	0.059359 (rank : 568)
Query Neighborhood Hits	599	Target Neighborhood Hits	216	Shared Neighborhood Hits	86
SwissProt Accessions	Q80Y50, Q3TFK0, Q5SX68, Q80TP1, Q8R0D9, Q8R2N5	Gene names	Camta2, Kiaa0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

CN155_HUMAN
θ value	θ > 10 (rank : 662)	NC score	0.050904 (rank : 620)
Query Neighborhood Hits	599	Target Neighborhood Hits	385	Shared Neighborhood Hits	67
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

CT012_MOUSE
θ value	θ > 10 (rank : 663)	NC score	0.191532 (rank : 355)
Query Neighborhood Hits	599	Target Neighborhood Hits	229	Shared Neighborhood Hits	156
SwissProt Accessions	Q8C008, Q8C060	Gene names
Domain Architecture	No domain graphic available
Description	Protein C20orf12 homolog.

CU081_HUMAN
θ value	θ > 10 (rank : 664)	NC score	0.066523 (rank : 522)
Query Neighborhood Hits	599	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NFU9	Gene names	C21orf81
Domain Architecture	No domain graphic available
Description	Protein C21orf81.

DGKH_HUMAN
θ value	θ > 10 (rank : 665)	NC score	0.054673 (rank : 596)
Query Neighborhood Hits	599	Target Neighborhood Hits	255	Shared Neighborhood Hits	52
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

DGKK_HUMAN
θ value	θ > 10 (rank : 666)	NC score	0.061131 (rank : 556)
Query Neighborhood Hits	599	Target Neighborhood Hits	378	Shared Neighborhood Hits	89
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

DGKZ_MOUSE
θ value	θ > 10 (rank : 667)	NC score	0.158133 (rank : 388)
Query Neighborhood Hits	599	Target Neighborhood Hits	542	Shared Neighborhood Hits	187
SwissProt Accessions	Q80UP3	Gene names	Dgkz
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

EFS_HUMAN
θ value	θ > 10 (rank : 668)	NC score	0.136477 (rank : 402)
Query Neighborhood Hits	599	Target Neighborhood Hits	348	Shared Neighborhood Hits	154
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	θ > 10 (rank : 669)	NC score	0.138046 (rank : 401)
Query Neighborhood Hits	599	Target Neighborhood Hits	389	Shared Neighborhood Hits	145
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

ENAH_MOUSE
θ value	θ > 10 (rank : 670)	NC score	0.052913 (rank : 608)
Query Neighborhood Hits	599	Target Neighborhood Hits	919	Shared Neighborhood Hits	140
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

ES8L1_HUMAN
θ value	θ > 10 (rank : 671)	NC score	0.081273 (rank : 484)
Query Neighborhood Hits	599	Target Neighborhood Hits	162	Shared Neighborhood Hits	91
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_MOUSE
θ value	θ > 10 (rank : 672)	NC score	0.078400 (rank : 491)
Query Neighborhood Hits	599	Target Neighborhood Hits	143	Shared Neighborhood Hits	75
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

FGD1_HUMAN
θ value	θ > 10 (rank : 673)	NC score	0.065851 (rank : 527)
Query Neighborhood Hits	599	Target Neighborhood Hits	367	Shared Neighborhood Hits	92
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	θ > 10 (rank : 674)	NC score	0.062187 (rank : 544)
Query Neighborhood Hits	599	Target Neighborhood Hits	387	Shared Neighborhood Hits	80
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_HUMAN
θ value	θ > 10 (rank : 675)	NC score	0.050570 (rank : 623)
Query Neighborhood Hits	599	Target Neighborhood Hits	151	Shared Neighborhood Hits	34
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD3_MOUSE
θ value	θ > 10 (rank : 676)	NC score	0.050433 (rank : 625)
Query Neighborhood Hits	599	Target Neighborhood Hits	257	Shared Neighborhood Hits	36
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FNBP2_HUMAN
θ value	θ > 10 (rank : 677)	NC score	0.116029 (rank : 429)
Query Neighborhood Hits	599	Target Neighborhood Hits	432	Shared Neighborhood Hits	164
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

GLSK_HUMAN
θ value	θ > 10 (rank : 678)	NC score	0.186755 (rank : 362)
Query Neighborhood Hits	599	Target Neighborhood Hits	204	Shared Neighborhood Hits	166
SwissProt Accessions	O94925, Q9UL05, Q9UL06, Q9UL07, Q9UN40	Gene names	GLS, GLS1, KIAA0838
Domain Architecture
Description	Glutaminase kidney isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (K-glutaminase).

GLSL_HUMAN
θ value	θ > 10 (rank : 679)	NC score	0.208193 (rank : 325)
Query Neighborhood Hits	599	Target Neighborhood Hits	211	Shared Neighborhood Hits	172
SwissProt Accessions	Q9UI32, Q9NYY2, Q9UI31	Gene names	GLS2, GA
Domain Architecture
Description	Glutaminase liver isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (L-glutaminase).

GLSL_MOUSE
θ value	θ > 10 (rank : 680)	NC score	0.201357 (rank : 332)
Query Neighborhood Hits	599	Target Neighborhood Hits	212	Shared Neighborhood Hits	170
SwissProt Accessions	Q571F8	Gene names	Gls2, Kiaa4146
Domain Architecture	No domain graphic available
Description	Glutaminase liver isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (L-glutaminase).

GMIP_HUMAN
θ value	θ > 10 (rank : 681)	NC score	0.058009 (rank : 576)
Query Neighborhood Hits	599	Target Neighborhood Hits	225	Shared Neighborhood Hits	30
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

GMIP_MOUSE
θ value	θ > 10 (rank : 682)	NC score	0.061021 (rank : 558)
Query Neighborhood Hits	599	Target Neighborhood Hits	202	Shared Neighborhood Hits	30
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

GRLF1_HUMAN
θ value	θ > 10 (rank : 683)	NC score	0.055825 (rank : 585)
Query Neighborhood Hits	599	Target Neighborhood Hits	167	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

IKBL_HUMAN
θ value	θ > 10 (rank : 684)	NC score	0.148159 (rank : 391)
Query Neighborhood Hits	599	Target Neighborhood Hits	168	Shared Neighborhood Hits	133
SwissProt Accessions	Q9UBC1, Q14625, Q9UBX4	Gene names	NFKBIL1, IKBL
Domain Architecture
Description	NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like) (I- kappa-B-like) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1).

IKBL_MOUSE
θ value	θ > 10 (rank : 685)	NC score	0.148317 (rank : 390)
Query Neighborhood Hits	599	Target Neighborhood Hits	196	Shared Neighborhood Hits	138
SwissProt Accessions	O88995, Q91X16, Q9R1Y3	Gene names	Nfkbil1, Ikbl
Domain Architecture
Description	NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like) (I- kappa-B-like) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1).

JIP1_HUMAN
θ value	θ > 10 (rank : 686)	NC score	0.063085 (rank : 538)
Query Neighborhood Hits	599	Target Neighborhood Hits	271	Shared Neighborhood Hits	68
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP1_MOUSE
θ value	θ > 10 (rank : 687)	NC score	0.062086 (rank : 545)
Query Neighborhood Hits	599	Target Neighborhood Hits	259	Shared Neighborhood Hits	68
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

KRIT1_HUMAN
θ value	θ > 10 (rank : 688)	NC score	0.271193 (rank : 247)
Query Neighborhood Hits	599	Target Neighborhood Hits	258	Shared Neighborhood Hits	193
SwissProt Accessions	O00522, O43894, Q506L6, Q6U276, Q75N19, Q9H180, Q9H264, Q9HAX5	Gene names	KRIT1, CCM1
Domain Architecture
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein).

KRIT1_MOUSE
θ value	θ > 10 (rank : 689)	NC score	0.277083 (rank : 243)
Query Neighborhood Hits	599	Target Neighborhood Hits	258	Shared Neighborhood Hits	200
SwissProt Accessions	Q6S5J6, Q6VSV2, Q7TPR8, Q8C9Q6, Q9EPY2, Q9ERH0	Gene names	Krit1, Ccm1
Domain Architecture	No domain graphic available
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog).

M3KL4_HUMAN
θ value	θ > 10 (rank : 690)	NC score	0.054805 (rank : 595)
Query Neighborhood Hits	599	Target Neighborhood Hits	1087	Shared Neighborhood Hits	168
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

MCF2L_MOUSE
θ value	θ > 10 (rank : 691)	NC score	0.061083 (rank : 557)
Query Neighborhood Hits	599	Target Neighborhood Hits	255	Shared Neighborhood Hits	58
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 692)	NC score	0.054147 (rank : 597)
Query Neighborhood Hits	599	Target Neighborhood Hits	166	Shared Neighborhood Hits	40
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MLL2_HUMAN
θ value	θ > 10 (rank : 693)	NC score	0.050677 (rank : 622)
Query Neighborhood Hits	599	Target Neighborhood Hits	1788	Shared Neighborhood Hits	178
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

MPP8_HUMAN
θ value	θ > 10 (rank : 694)	NC score	0.293595 (rank : 233)
Query Neighborhood Hits	599	Target Neighborhood Hits	948	Shared Neighborhood Hits	257
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

MTPN_HUMAN
θ value	θ > 10 (rank : 695)	NC score	0.394963 (rank : 118)
Query Neighborhood Hits	599	Target Neighborhood Hits	269	Shared Neighborhood Hits	223
SwissProt Accessions	P58546	Gene names	MTPN
Domain Architecture
Description	Myotrophin (Protein V-1).

MTPN_MOUSE
θ value	θ > 10 (rank : 696)	NC score	0.400822 (rank : 101)
Query Neighborhood Hits	599	Target Neighborhood Hits	269	Shared Neighborhood Hits	223
SwissProt Accessions	P62774, P80144, Q543M6, Q9DCN8	Gene names	Mtpn, Gcdp
Domain Architecture	No domain graphic available
Description	Myotrophin (Protein V-1) (Granule cell differentiation protein).

MUC7_HUMAN
θ value	θ > 10 (rank : 697)	NC score	0.065196 (rank : 529)
Query Neighborhood Hits	599	Target Neighborhood Hits	538	Shared Neighborhood Hits	97
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

MYO9B_HUMAN
θ value	θ > 10 (rank : 698)	NC score	0.055661 (rank : 587)
Query Neighborhood Hits	599	Target Neighborhood Hits	641	Shared Neighborhood Hits	79
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

MYO9B_MOUSE
θ value	θ > 10 (rank : 699)	NC score	0.051247 (rank : 617)
Query Neighborhood Hits	599	Target Neighborhood Hits	311	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

NCF1_MOUSE
θ value	θ > 10 (rank : 700)	NC score	0.161633 (rank : 385)
Query Neighborhood Hits	599	Target Neighborhood Hits	198	Shared Neighborhood Hits	132
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCK2_HUMAN
θ value	θ > 10 (rank : 701)	NC score	0.168122 (rank : 381)
Query Neighborhood Hits	599	Target Neighborhood Hits	310	Shared Neighborhood Hits	147
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NCOA6_HUMAN
θ value	θ > 10 (rank : 702)	NC score	0.061409 (rank : 550)
Query Neighborhood Hits	599	Target Neighborhood Hits	1202	Shared Neighborhood Hits	118
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

NGEF_MOUSE
θ value	θ > 10 (rank : 703)	NC score	0.085377 (rank : 476)
Query Neighborhood Hits	599	Target Neighborhood Hits	228	Shared Neighborhood Hits	90
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NOXO1_HUMAN
θ value	θ > 10 (rank : 704)	NC score	0.073722 (rank : 501)
Query Neighborhood Hits	599	Target Neighborhood Hits	100	Shared Neighborhood Hits	72
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 705)	NC score	0.098131 (rank : 455)
Query Neighborhood Hits	599	Target Neighborhood Hits	114	Shared Neighborhood Hits	80
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_HUMAN
θ value	θ > 10 (rank : 706)	NC score	0.118288 (rank : 424)
Query Neighborhood Hits	599	Target Neighborhood Hits	288	Shared Neighborhood Hits	129
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 707)	NC score	0.130643 (rank : 410)
Query Neighborhood Hits	599	Target Neighborhood Hits	267	Shared Neighborhood Hits	134
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OSBL7_HUMAN
θ value	θ > 10 (rank : 708)	NC score	0.061190 (rank : 555)
Query Neighborhood Hits	599	Target Neighborhood Hits	71	Shared Neighborhood Hits	19
SwissProt Accessions	Q9BZF2	Gene names	OSBPL7, ORP7
Domain Architecture
Description	Oxysterol-binding protein-related protein 7 (OSBP-related protein 7) (ORP-7).

P85A_HUMAN
θ value	θ > 10 (rank : 709)	NC score	0.077777 (rank : 493)
Query Neighborhood Hits	599	Target Neighborhood Hits	479	Shared Neighborhood Hits	116
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 710)	NC score	0.078389 (rank : 492)
Query Neighborhood Hits	599	Target Neighborhood Hits	435	Shared Neighborhood Hits	116
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

PEX13_HUMAN
θ value	θ > 10 (rank : 711)	NC score	0.120049 (rank : 421)
Query Neighborhood Hits	599	Target Neighborhood Hits	128	Shared Neighborhood Hits	93
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 712)	NC score	0.125970 (rank : 412)
Query Neighborhood Hits	599	Target Neighborhood Hits	126	Shared Neighborhood Hits	94
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PKHA2_HUMAN
θ value	θ > 10 (rank : 713)	NC score	0.076277 (rank : 497)
Query Neighborhood Hits	599	Target Neighborhood Hits	119	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHA2_MOUSE
θ value	θ > 10 (rank : 714)	NC score	0.079835 (rank : 488)
Query Neighborhood Hits	599	Target Neighborhood Hits	116	Shared Neighborhood Hits	41
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA4_HUMAN
θ value	θ > 10 (rank : 715)	NC score	0.063965 (rank : 533)
Query Neighborhood Hits	599	Target Neighborhood Hits	283	Shared Neighborhood Hits	73
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_MOUSE
θ value	θ > 10 (rank : 716)	NC score	0.055953 (rank : 582)
Query Neighborhood Hits	599	Target Neighborhood Hits	202	Shared Neighborhood Hits	49
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA6_HUMAN
θ value	θ > 10 (rank : 717)	NC score	0.095931 (rank : 459)
Query Neighborhood Hits	599	Target Neighborhood Hits	556	Shared Neighborhood Hits	93
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	θ > 10 (rank : 718)	NC score	0.104445 (rank : 442)
Query Neighborhood Hits	599	Target Neighborhood Hits	591	Shared Neighborhood Hits	97
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHG1_HUMAN
θ value	θ > 10 (rank : 719)	NC score	0.068831 (rank : 509)
Query Neighborhood Hits	599	Target Neighborhood Hits	174	Shared Neighborhood Hits	33
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PPIP2_HUMAN
θ value	θ > 10 (rank : 720)	NC score	0.052530 (rank : 612)
Query Neighborhood Hits	599	Target Neighborhood Hits	254	Shared Neighborhood Hits	46
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PRB3_HUMAN
θ value	θ > 10 (rank : 721)	NC score	0.050542 (rank : 624)
Query Neighborhood Hits	599	Target Neighborhood Hits	318	Shared Neighborhood Hits	65
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

PRB4S_HUMAN
θ value	θ > 10 (rank : 722)	NC score	0.056982 (rank : 579)
Query Neighborhood Hits	599	Target Neighborhood Hits	330	Shared Neighborhood Hits	72
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

PREX1_HUMAN
θ value	θ > 10 (rank : 723)	NC score	0.066624 (rank : 521)
Query Neighborhood Hits	599	Target Neighborhood Hits	177	Shared Neighborhood Hits	30
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PRG4_HUMAN
θ value	θ > 10 (rank : 724)	NC score	0.053020 (rank : 607)
Query Neighborhood Hits	599	Target Neighborhood Hits	764	Shared Neighborhood Hits	108
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PRP1_HUMAN
θ value	θ > 10 (rank : 725)	NC score	0.061224 (rank : 554)
Query Neighborhood Hits	599	Target Neighborhood Hits	385	Shared Neighborhood Hits	77
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

PRP2_MOUSE
θ value	θ > 10 (rank : 726)	NC score	0.066423 (rank : 523)
Query Neighborhood Hits	599	Target Neighborhood Hits	347	Shared Neighborhood Hits	80
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

PRR12_HUMAN
θ value	θ > 10 (rank : 727)	NC score	0.061302 (rank : 551)
Query Neighborhood Hits	599	Target Neighborhood Hits	460	Shared Neighborhood Hits	97
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

RAPH1_HUMAN
θ value	θ > 10 (rank : 728)	NC score	0.058196 (rank : 573)
Query Neighborhood Hits	599	Target Neighborhood Hits	593	Shared Neighborhood Hits	113
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

RBP1_HUMAN
θ value	θ > 10 (rank : 729)	NC score	0.067306 (rank : 519)
Query Neighborhood Hits	599	Target Neighborhood Hits	521	Shared Neighborhood Hits	65
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RBP1_MOUSE
θ value	θ > 10 (rank : 730)	NC score	0.067844 (rank : 515)
Query Neighborhood Hits	599	Target Neighborhood Hits	493	Shared Neighborhood Hits	63
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RGAP1_HUMAN
θ value	θ > 10 (rank : 731)	NC score	0.060255 (rank : 563)
Query Neighborhood Hits	599	Target Neighborhood Hits	189	Shared Neighborhood Hits	25
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RGAP1_MOUSE
θ value	θ > 10 (rank : 732)	NC score	0.062385 (rank : 542)
Query Neighborhood Hits	599	Target Neighborhood Hits	185	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RHG04_HUMAN
θ value	θ > 10 (rank : 733)	NC score	0.132127 (rank : 407)
Query Neighborhood Hits	599	Target Neighborhood Hits	307	Shared Neighborhood Hits	143
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RHG05_HUMAN
θ value	θ > 10 (rank : 734)	NC score	0.055825 (rank : 584)
Query Neighborhood Hits	599	Target Neighborhood Hits	158	Shared Neighborhood Hits	19
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG05_MOUSE
θ value	θ > 10 (rank : 735)	NC score	0.055835 (rank : 583)
Query Neighborhood Hits	599	Target Neighborhood Hits	165	Shared Neighborhood Hits	21
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG06_HUMAN
θ value	θ > 10 (rank : 736)	NC score	0.055193 (rank : 593)
Query Neighborhood Hits	599	Target Neighborhood Hits	114	Shared Neighborhood Hits	22
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG06_MOUSE
θ value	θ > 10 (rank : 737)	NC score	0.053076 (rank : 606)
Query Neighborhood Hits	599	Target Neighborhood Hits	105	Shared Neighborhood Hits	13
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG12_HUMAN
θ value	θ > 10 (rank : 738)	NC score	0.065908 (rank : 526)
Query Neighborhood Hits	599	Target Neighborhood Hits	190	Shared Neighborhood Hits	44
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	θ > 10 (rank : 739)	NC score	0.069091 (rank : 507)
Query Neighborhood Hits	599	Target Neighborhood Hits	204	Shared Neighborhood Hits	53
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG18_HUMAN
θ value	θ > 10 (rank : 740)	NC score	0.053901 (rank : 598)
Query Neighborhood Hits	599	Target Neighborhood Hits	90	Shared Neighborhood Hits	14
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

RHG18_MOUSE
θ value	θ > 10 (rank : 741)	NC score	0.051920 (rank : 614)
Query Neighborhood Hits	599	Target Neighborhood Hits	110	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

RHG25_HUMAN
θ value	θ > 10 (rank : 742)	NC score	0.057400 (rank : 577)
Query Neighborhood Hits	599	Target Neighborhood Hits	550	Shared Neighborhood Hits	83
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_MOUSE
θ value	θ > 10 (rank : 743)	NC score	0.061650 (rank : 548)
Query Neighborhood Hits	599	Target Neighborhood Hits	492	Shared Neighborhood Hits	75
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RIMB2_MOUSE
θ value	θ > 10 (rank : 744)	NC score	0.120987 (rank : 420)
Query Neighborhood Hits	599	Target Neighborhood Hits	246	Shared Neighborhood Hits	103
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RN5A_MOUSE
θ value	θ > 10 (rank : 745)	NC score	0.327032 (rank : 214)
Query Neighborhood Hits	599	Target Neighborhood Hits	899	Shared Neighborhood Hits	242
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

RSNL2_HUMAN
θ value	θ > 10 (rank : 746)	NC score	0.087271 (rank : 470)
Query Neighborhood Hits	599	Target Neighborhood Hits	136	Shared Neighborhood Hits	105
SwissProt Accessions	Q8N3C7, Q7Z4U3, Q96BR7, Q96MA5, Q9H7C0	Gene names	RSNL2
Domain Architecture	No domain graphic available
Description	Restin-like protein 2.

RSNL2_MOUSE
θ value	θ > 10 (rank : 747)	NC score	0.076797 (rank : 495)
Query Neighborhood Hits	599	Target Neighborhood Hits	129	Shared Neighborhood Hits	91
SwissProt Accessions	Q8CI96, Q8BW09, Q921Q4, Q9D2S6	Gene names	Rsnl2
Domain Architecture	No domain graphic available
Description	Restin-like protein 2.

SASH1_HUMAN
θ value	θ > 10 (rank : 748)	NC score	0.053872 (rank : 600)
Query Neighborhood Hits	599	Target Neighborhood Hits	292	Shared Neighborhood Hits	87
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SASH1_MOUSE
θ value	θ > 10 (rank : 749)	NC score	0.060595 (rank : 560)
Query Neighborhood Hits	599	Target Neighborhood Hits	263	Shared Neighborhood Hits	77
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SF3A2_MOUSE
θ value	θ > 10 (rank : 750)	NC score	0.052544 (rank : 611)
Query Neighborhood Hits	599	Target Neighborhood Hits	247	Shared Neighborhood Hits	59
SwissProt Accessions	Q62203	Gene names	Sf3a2, Sap62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

SHAN2_MOUSE
θ value	θ > 10 (rank : 751)	NC score	0.084547 (rank : 478)
Query Neighborhood Hits	599	Target Neighborhood Hits	446	Shared Neighborhood Hits	127
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SHLB1_HUMAN
θ value	θ > 10 (rank : 752)	NC score	0.105019 (rank : 441)
Query Neighborhood Hits	599	Target Neighborhood Hits	96	Shared Neighborhood Hits	72
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB1_MOUSE
θ value	θ > 10 (rank : 753)	NC score	0.118281 (rank : 425)
Query Neighborhood Hits	599	Target Neighborhood Hits	101	Shared Neighborhood Hits	76
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SHLB2_HUMAN
θ value	θ > 10 (rank : 754)	NC score	0.085993 (rank : 474)
Query Neighborhood Hits	599	Target Neighborhood Hits	86	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	θ > 10 (rank : 755)	NC score	0.086710 (rank : 473)
Query Neighborhood Hits	599	Target Neighborhood Hits	88	Shared Neighborhood Hits	60
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SLY_HUMAN
θ value	θ > 10 (rank : 756)	NC score	0.052883 (rank : 610)
Query Neighborhood Hits	599	Target Neighborhood Hits	81	Shared Neighborhood Hits	54
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SLY_MOUSE
θ value	θ > 10 (rank : 757)	NC score	0.060932 (rank : 559)
Query Neighborhood Hits	599	Target Neighborhood Hits	108	Shared Neighborhood Hits	58
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SNX9_HUMAN
θ value	θ > 10 (rank : 758)	NC score	0.100997 (rank : 450)
Query Neighborhood Hits	599	Target Neighborhood Hits	148	Shared Neighborhood Hits	79
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SNX9_MOUSE
θ value	θ > 10 (rank : 759)	NC score	0.088969 (rank : 467)
Query Neighborhood Hits	599	Target Neighborhood Hits	141	Shared Neighborhood Hits	72
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SPN90_HUMAN
θ value	θ > 10 (rank : 760)	NC score	0.073960 (rank : 500)
Query Neighborhood Hits	599	Target Neighborhood Hits	157	Shared Neighborhood Hits	83
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 761)	NC score	0.068058 (rank : 514)
Query Neighborhood Hits	599	Target Neighborhood Hits	157	Shared Neighborhood Hits	79
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRGP1_HUMAN
θ value	θ > 10 (rank : 762)	NC score	0.112627 (rank : 433)
Query Neighborhood Hits	599	Target Neighborhood Hits	390	Shared Neighborhood Hits	151
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
θ value	θ > 10 (rank : 763)	NC score	0.117901 (rank : 426)
Query Neighborhood Hits	599	Target Neighborhood Hits	331	Shared Neighborhood Hits	145
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRRM1_HUMAN
θ value	θ > 10 (rank : 764)	NC score	0.053897 (rank : 599)
Query Neighborhood Hits	599	Target Neighborhood Hits	690	Shared Neighborhood Hits	95
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

SRRM1_MOUSE
θ value	θ > 10 (rank : 765)	NC score	0.060034 (rank : 565)
Query Neighborhood Hits	599	Target Neighborhood Hits	966	Shared Neighborhood Hits	118
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

SRRM2_HUMAN
θ value	θ > 10 (rank : 766)	NC score	0.056767 (rank : 580)
Query Neighborhood Hits	599	Target Neighborhood Hits	1296	Shared Neighborhood Hits	131
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

STS1_HUMAN
θ value	θ > 10 (rank : 767)	NC score	0.061807 (rank : 546)
Query Neighborhood Hits	599	Target Neighborhood Hits	106	Shared Neighborhood Hits	68
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
θ value	θ > 10 (rank : 768)	NC score	0.061528 (rank : 549)
Query Neighborhood Hits	599	Target Neighborhood Hits	104	Shared Neighborhood Hits	65
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

TAF4_HUMAN
θ value	θ > 10 (rank : 769)	NC score	0.059314 (rank : 569)
Query Neighborhood Hits	599	Target Neighborhood Hits	687	Shared Neighborhood Hits	110
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

TAGAP_HUMAN
θ value	θ > 10 (rank : 770)	NC score	0.051546 (rank : 616)
Query Neighborhood Hits	599	Target Neighborhood Hits	82	Shared Neighborhood Hits	16
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

TARA_HUMAN
θ value	θ > 10 (rank : 771)	NC score	0.052908 (rank : 609)
Query Neighborhood Hits	599	Target Neighborhood Hits	1626	Shared Neighborhood Hits	159
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TARA_MOUSE
θ value	θ > 10 (rank : 772)	NC score	0.050864 (rank : 621)
Query Neighborhood Hits	599	Target Neighborhood Hits	1133	Shared Neighborhood Hits	134
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TEX14_HUMAN
θ value	θ > 10 (rank : 773)	NC score	0.177880 (rank : 372)
Query Neighborhood Hits	599	Target Neighborhood Hits	1103	Shared Neighborhood Hits	250
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
θ value	θ > 10 (rank : 774)	NC score	0.178723 (rank : 371)
Query Neighborhood Hits	599	Target Neighborhood Hits	1333	Shared Neighborhood Hits	270
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TIAM1_HUMAN
θ value	θ > 10 (rank : 775)	NC score	0.064987 (rank : 530)
Query Neighborhood Hits	599	Target Neighborhood Hits	225	Shared Neighborhood Hits	37
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TRPV1_HUMAN
θ value	θ > 10 (rank : 776)	NC score	0.091300 (rank : 464)
Query Neighborhood Hits	599	Target Neighborhood Hits	184	Shared Neighborhood Hits	130
SwissProt Accessions	Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22	Gene names	TRPV1, VR1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Capsaicin receptor).

TRPV1_MOUSE
θ value	θ > 10 (rank : 777)	NC score	0.094792 (rank : 461)
Query Neighborhood Hits	599	Target Neighborhood Hits	189	Shared Neighborhood Hits	133
SwissProt Accessions	Q704Y3, Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0	Gene names	Trpv1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).

TRPV2_HUMAN
θ value	θ > 10 (rank : 778)	NC score	0.070476 (rank : 506)
Query Neighborhood Hits	599	Target Neighborhood Hits	130	Shared Neighborhood Hits	98
SwissProt Accessions	Q9Y5S1, Q9Y670	Gene names	TRPV2, VRL
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1).

TRPV2_MOUSE
θ value	θ > 10 (rank : 779)	NC score	0.053156 (rank : 605)
Query Neighborhood Hits	599	Target Neighborhood Hits	111	Shared Neighborhood Hits	79
SwissProt Accessions	Q9WTR1, Q99K71	Gene names	Trpv2, Grc
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Growth factor-regulated calcium channel) (GRC).

TRPV3_HUMAN
θ value	θ > 10 (rank : 780)	NC score	0.072668 (rank : 505)
Query Neighborhood Hits	599	Target Neighborhood Hits	198	Shared Neighborhood Hits	117
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

TRPV3_MOUSE
θ value	θ > 10 (rank : 781)	NC score	0.073400 (rank : 503)
Query Neighborhood Hits	599	Target Neighborhood Hits	188	Shared Neighborhood Hits	107
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

TRPV5_HUMAN
θ value	θ > 10 (rank : 782)	NC score	0.174139 (rank : 377)
Query Neighborhood Hits	599	Target Neighborhood Hits	261	Shared Neighborhood Hits	184
SwissProt Accessions	Q9NQA5, Q8NDW5, Q8NDX7, Q8NDX8, Q96PM6	Gene names	TRPV5, ECAC1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Calcium transport protein 2) (CaT2).

TRPV5_MOUSE
θ value	θ > 10 (rank : 783)	NC score	0.190981 (rank : 356)
Query Neighborhood Hits	599	Target Neighborhood Hits	278	Shared Neighborhood Hits	203
SwissProt Accessions	P69744	Gene names	Trpv5
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC1) (Calcium transport protein 2) (CaT2).

TRPV6_HUMAN
θ value	θ > 10 (rank : 784)	NC score	0.169690 (rank : 379)
Query Neighborhood Hits	599	Target Neighborhood Hits	262	Shared Neighborhood Hits	184
SwissProt Accessions	Q9H1D0, Q8TDL3, Q8WXR8, Q96LC5, Q9H1D1, Q9H296	Gene names	TRPV6, ECAC2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1) (CaT-like) (CaT-L).

TRPV6_MOUSE
θ value	θ > 10 (rank : 785)	NC score	0.210577 (rank : 322)
Query Neighborhood Hits	599	Target Neighborhood Hits	284	Shared Neighborhood Hits	204
SwissProt Accessions	Q91WD2	Gene names	Trpv6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1).

VAV3_HUMAN
θ value	θ > 10 (rank : 786)	NC score	0.124586 (rank : 413)
Query Neighborhood Hits	599	Target Neighborhood Hits	398	Shared Neighborhood Hits	144
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 787)	NC score	0.122213 (rank : 417)
Query Neighborhood Hits	599	Target Neighborhood Hits	404	Shared Neighborhood Hits	141
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

WASIP_HUMAN
θ value	θ > 10 (rank : 788)	NC score	0.074548 (rank : 499)
Query Neighborhood Hits	599	Target Neighborhood Hits	458	Shared Neighborhood Hits	92
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

WASIP_MOUSE
θ value	θ > 10 (rank : 789)	NC score	0.063722 (rank : 535)
Query Neighborhood Hits	599	Target Neighborhood Hits	392	Shared Neighborhood Hits	92
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

WIRE_HUMAN
θ value	θ > 10 (rank : 790)	NC score	0.050941 (rank : 619)
Query Neighborhood Hits	599	Target Neighborhood Hits	329	Shared Neighborhood Hits	82
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

Hits sorted by NC score

DDEF2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	599	Target Neighborhood Hits	599	Shared Neighborhood Hits	599
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
NC score	0.983964 (rank : 2)	θ value	0 (rank : 3)
Query Neighborhood Hits	599	Target Neighborhood Hits	625	Shared Neighborhood Hits	500
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF1_MOUSE
NC score	0.935238 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	599	Target Neighborhood Hits	592	Shared Neighborhood Hits	376
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDFL1_HUMAN
NC score	0.899353 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	599	Target Neighborhood Hits	353	Shared Neighborhood Hits	263
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

DDFL1_MOUSE
NC score	0.896132 (rank : 5)	θ value	0 (rank : 5)
Query Neighborhood Hits	599	Target Neighborhood Hits	324	Shared Neighborhood Hits	260
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

CENB1_HUMAN
NC score	0.788057 (rank : 6)	θ value	2.50074e-42 (rank : 8)
Query Neighborhood Hits	599	Target Neighborhood Hits	383	Shared Neighborhood Hits	264
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

CENB5_HUMAN
NC score	0.786941 (rank : 7)	θ value	2.85459e-46 (rank : 6)
Query Neighborhood Hits	599	Target Neighborhood Hits	395	Shared Neighborhood Hits	273
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CENB2_HUMAN
NC score	0.775289 (rank : 8)	θ value	6.35935e-46 (rank : 7)
Query Neighborhood Hits	599	Target Neighborhood Hits	425	Shared Neighborhood Hits	263
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENG1_MOUSE
NC score	0.659977 (rank : 9)	θ value	1.5242e-23 (rank : 14)
Query Neighborhood Hits	599	Target Neighborhood Hits	531	Shared Neighborhood Hits	259
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

CENG1_HUMAN
NC score	0.654151 (rank : 10)	θ value	5.23862e-24 (rank : 13)
Query Neighborhood Hits	599	Target Neighborhood Hits	544	Shared Neighborhood Hits	256
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

GIT2_MOUSE
NC score	0.642708 (rank : 11)	θ value	1.42992e-13 (rank : 26)
Query Neighborhood Hits	599	Target Neighborhood Hits	323	Shared Neighborhood Hits	242
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

CENG3_MOUSE
NC score	0.639325 (rank : 12)	θ value	6.61148e-27 (rank : 9)
Query Neighborhood Hits	599	Target Neighborhood Hits	467	Shared Neighborhood Hits	230
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_HUMAN
NC score	0.638601 (rank : 13)	θ value	1.92365e-26 (rank : 10)
Query Neighborhood Hits	599	Target Neighborhood Hits	455	Shared Neighborhood Hits	230
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG2_MOUSE
NC score	0.629816 (rank : 14)	θ value	2.77775e-25 (rank : 12)
Query Neighborhood Hits	599	Target Neighborhood Hits	463	Shared Neighborhood Hits	239
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

CENG2_HUMAN
NC score	0.627690 (rank : 15)	θ value	2.12685e-25 (rank : 11)
Query Neighborhood Hits	599	Target Neighborhood Hits	471	Shared Neighborhood Hits	239
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

GIT2_HUMAN
NC score	0.626367 (rank : 16)	θ value	2.69671e-12 (rank : 27)
Query Neighborhood Hits	599	Target Neighborhood Hits	381	Shared Neighborhood Hits	238
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

GIT1_HUMAN
NC score	0.620988 (rank : 17)	θ value	2.98157e-11 (rank : 29)
Query Neighborhood Hits	599	Target Neighborhood Hits	336	Shared Neighborhood Hits	245
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

GIT1_MOUSE
NC score	0.620676 (rank : 18)	θ value	2.98157e-11 (rank : 30)
Query Neighborhood Hits	599	Target Neighborhood Hits	341	Shared Neighborhood Hits	243
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

SMAP1_MOUSE
NC score	0.614673 (rank : 19)	θ value	7.58209e-15 (rank : 20)
Query Neighborhood Hits	599	Target Neighborhood Hits	120	Shared Neighborhood Hits	52
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMAP1_HUMAN
NC score	0.612902 (rank : 20)	θ value	9.90251e-15 (rank : 22)
Query Neighborhood Hits	599	Target Neighborhood Hits	98	Shared Neighborhood Hits	50
SwissProt Accessions	Q8IYB5, Q53H70, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4	Gene names	SMAP1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMP1L_HUMAN
NC score	0.610966 (rank : 21)	θ value	1.09485e-13 (rank : 25)
Query Neighborhood Hits	599	Target Neighborhood Hits	74	Shared Neighborhood Hits	45
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

ARFG1_MOUSE
NC score	0.610386 (rank : 22)	θ value	9.90251e-15 (rank : 21)
Query Neighborhood Hits	599	Target Neighborhood Hits	51	Shared Neighborhood Hits	38
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

SMP1L_MOUSE
NC score	0.608990 (rank : 23)	θ value	8.38298e-14 (rank : 24)
Query Neighborhood Hits	599	Target Neighborhood Hits	70	Shared Neighborhood Hits	41
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

CENA1_HUMAN
NC score	0.601400 (rank : 24)	θ value	6.00763e-12 (rank : 28)
Query Neighborhood Hits	599	Target Neighborhood Hits	87	Shared Neighborhood Hits	49
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

ARFG1_HUMAN
NC score	0.596552 (rank : 25)	θ value	2.20605e-14 (rank : 23)
Query Neighborhood Hits	599	Target Neighborhood Hits	60	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N6T3, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0	Gene names	ARFGAP1, ARF1GAP
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

CENA2_MOUSE
NC score	0.573441 (rank : 26)	θ value	2.52405e-10 (rank : 31)
Query Neighborhood Hits	599	Target Neighborhood Hits	68	Shared Neighborhood Hits	45
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

ARFG3_HUMAN
NC score	0.573149 (rank : 27)	θ value	5.62301e-10 (rank : 33)
Query Neighborhood Hits	599	Target Neighborhood Hits	56	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ARFG3_MOUSE
NC score	0.570076 (rank : 28)	θ value	4.30538e-10 (rank : 32)
Query Neighborhood Hits	599	Target Neighborhood Hits	80	Shared Neighborhood Hits	39
SwissProt Accessions	Q9D8S3, Q99KN8	Gene names	Arfgap3
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

CENA2_HUMAN
NC score	0.565025 (rank : 29)	θ value	5.62301e-10 (rank : 34)
Query Neighborhood Hits	599	Target Neighborhood Hits	83	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

CEND1_HUMAN
NC score	0.494457 (rank : 30)	θ value	1.63225e-17 (rank : 16)
Query Neighborhood Hits	599	Target Neighborhood Hits	284	Shared Neighborhood Hits	75
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CEND1_MOUSE
NC score	0.492697 (rank : 31)	θ value	6.20254e-17 (rank : 17)
Query Neighborhood Hits	599	Target Neighborhood Hits	260	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CEND2_HUMAN
NC score	0.485135 (rank : 32)	θ value	1.33526e-19 (rank : 15)
Query Neighborhood Hits	599	Target Neighborhood Hits	166	Shared Neighborhood Hits	67
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

CEND3_HUMAN
NC score	0.476871 (rank : 33)	θ value	1.99529e-15 (rank : 18)
Query Neighborhood Hits	599	Target Neighborhood Hits	275	Shared Neighborhood Hits	82
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CT086_HUMAN
NC score	0.473004 (rank : 34)	θ value	0.00035302 (rank : 95)
Query Neighborhood Hits	599	Target Neighborhood Hits	277	Shared Neighborhood Hits	227
SwissProt Accessions	Q9BZ19, Q4VXE6	Gene names	C20orf86
Domain Architecture
Description	Putative uncharacterized protein C20orf86.

CEND3_MOUSE
NC score	0.469856 (rank : 35)	θ value	4.44505e-15 (rank : 19)
Query Neighborhood Hits	599	Target Neighborhood Hits	228	Shared Neighborhood Hits	72
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

OSTF1_MOUSE
NC score	0.467604 (rank : 36)	θ value	0.000158464 (rank : 79)
Query Neighborhood Hits	599	Target Neighborhood Hits	467	Shared Neighborhood Hits	347
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

ANR22_HUMAN
NC score	0.454309 (rank : 37)	θ value	1.29631e-06 (rank : 42)
Query Neighborhood Hits	599	Target Neighborhood Hits	243	Shared Neighborhood Hits	212
SwissProt Accessions	Q5VYY1, Q8WU06	Gene names	ANKRD22
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 22.

OSTF1_HUMAN
NC score	0.453022 (rank : 38)	θ value	0.000121331 (rank : 70)
Query Neighborhood Hits	599	Target Neighborhood Hits	466	Shared Neighborhood Hits	348
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

ANR37_MOUSE
NC score	0.440501 (rank : 39)	θ value	0.00509761 (rank : 164)
Query Neighborhood Hits	599	Target Neighborhood Hits	237	Shared Neighborhood Hits	208
SwissProt Accessions	Q569N2, Q8CHS0	Gene names	Ankrd37
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37.

ANKR6_HUMAN
NC score	0.440470 (rank : 40)	θ value	5.44631e-05 (rank : 54)
Query Neighborhood Hits	599	Target Neighborhood Hits	439	Shared Neighborhood Hits	248
SwissProt Accessions	Q9Y2G4, Q9NU24, Q9UFQ9	Gene names	ANKRD6, KIAA0957
Domain Architecture
Description	Ankyrin repeat domain-containing protein 6.

ANR46_HUMAN
NC score	0.439501 (rank : 41)	θ value	0.000158464 (rank : 74)
Query Neighborhood Hits	599	Target Neighborhood Hits	281	Shared Neighborhood Hits	223
SwissProt Accessions	Q86W74, Q6P9B7	Gene names	ANKRD46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

ANR39_HUMAN
NC score	0.439160 (rank : 42)	θ value	0.00390308 (rank : 153)
Query Neighborhood Hits	599	Target Neighborhood Hits	285	Shared Neighborhood Hits	230
SwissProt Accessions	Q53RE8, Q59FU2, Q8N5X5, Q9P0S5	Gene names	ANKRD39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ANR37_HUMAN
NC score	0.438605 (rank : 43)	θ value	0.00134147 (rank : 127)
Query Neighborhood Hits	599	Target Neighborhood Hits	247	Shared Neighborhood Hits	216
SwissProt Accessions	Q7Z713	Gene names	ANKRD37, LPR2BP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37 (Low-density lipoprotein receptor-related protein 2-binding protein) (hLrp2bp).

ANR39_MOUSE
NC score	0.437798 (rank : 44)	θ value	0.00298849 (rank : 146)
Query Neighborhood Hits	599	Target Neighborhood Hits	284	Shared Neighborhood Hits	227
SwissProt Accessions	Q9D2X0	Gene names	Ankrd39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

PSD10_HUMAN
NC score	0.432462 (rank : 45)	θ value	0.00020696 (rank : 85)
Query Neighborhood Hits	599	Target Neighborhood Hits	301	Shared Neighborhood Hits	231
SwissProt Accessions	O75832	Gene names	PSMD10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

PSD10_MOUSE
NC score	0.430401 (rank : 46)	θ value	0.00035302 (rank : 97)
Query Neighborhood Hits	599	Target Neighborhood Hits	293	Shared Neighborhood Hits	229
SwissProt Accessions	Q9Z2X2, Q9D7N8	Gene names	Psmd10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

ANR42_HUMAN
NC score	0.430233 (rank : 47)	θ value	7.1131e-05 (rank : 60)
Query Neighborhood Hits	599	Target Neighborhood Hits	284	Shared Neighborhood Hits	228
SwissProt Accessions	Q8N9B4, Q49A49	Gene names	ANKRD42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

ANR10_HUMAN
NC score	0.428682 (rank : 48)	θ value	0.000270298 (rank : 86)
Query Neighborhood Hits	599	Target Neighborhood Hits	289	Shared Neighborhood Hits	227
SwissProt Accessions	Q9NXR5	Gene names	ANKRD10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

ANR42_MOUSE
NC score	0.428337 (rank : 49)	θ value	7.1131e-05 (rank : 61)
Query Neighborhood Hits	599	Target Neighborhood Hits	334	Shared Neighborhood Hits	235
SwissProt Accessions	Q3V096, Q8BX55, Q8BZT3, Q8C0T6, Q8C0X5	Gene names	Ankrd42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

MYPT1_MOUSE
NC score	0.427810 (rank : 50)	θ value	5.44631e-05 (rank : 58)
Query Neighborhood Hits	599	Target Neighborhood Hits	539	Shared Neighborhood Hits	257
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

ANR46_MOUSE
NC score	0.427384 (rank : 51)	θ value	0.000602161 (rank : 104)
Query Neighborhood Hits	599	Target Neighborhood Hits	274	Shared Neighborhood Hits	218
SwissProt Accessions	Q8BTZ5, Q1LZK9, Q8BV97	Gene names	Ankrd46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

ANK1_HUMAN
NC score	0.424516 (rank : 52)	θ value	9.92553e-07 (rank : 40)
Query Neighborhood Hits	599	Target Neighborhood Hits	416	Shared Neighborhood Hits	235
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

ANR23_HUMAN
NC score	0.424332 (rank : 53)	θ value	0.0113563 (rank : 193)
Query Neighborhood Hits	599	Target Neighborhood Hits	291	Shared Neighborhood Hits	231
SwissProt Accessions	Q86SG2, Q711K7, Q8NAJ7	Gene names	ANKRD23, DARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein) (Muscle ankyrin repeat protein 3).

ANR10_MOUSE
NC score	0.424152 (rank : 54)	θ value	0.000602161 (rank : 103)
Query Neighborhood Hits	599	Target Neighborhood Hits	273	Shared Neighborhood Hits	225
SwissProt Accessions	Q99LW0	Gene names	Ankrd10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

ANK1_MOUSE
NC score	0.423255 (rank : 55)	θ value	7.59969e-07 (rank : 38)
Query Neighborhood Hits	599	Target Neighborhood Hits	430	Shared Neighborhood Hits	236
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

PA2G6_MOUSE
NC score	0.422434 (rank : 56)	θ value	0.00020696 (rank : 84)
Query Neighborhood Hits	599	Target Neighborhood Hits	293	Shared Neighborhood Hits	231
SwissProt Accessions	P97819, Q99LA9, Q9JK61	Gene names	Pla2g6
Domain Architecture
Description	85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4) (iPLA2) (CaI- PLA2) (Group VI phospholipase A2) (GVI PLA2).

ANKR1_MOUSE
NC score	0.422025 (rank : 57)	θ value	9.29e-05 (rank : 62)
Query Neighborhood Hits	599	Target Neighborhood Hits	316	Shared Neighborhood Hits	233
SwissProt Accessions	Q9CR42, O55014, Q3UIF7, Q3UJ39, Q792Q9	Gene names	Ankrd1, Carp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein).

CSKI2_HUMAN
NC score	0.421918 (rank : 58)	θ value	9.29e-05 (rank : 63)
Query Neighborhood Hits	599	Target Neighborhood Hits	747	Shared Neighborhood Hits	326
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CSKI2_MOUSE
NC score	0.421586 (rank : 59)	θ value	9.29e-05 (rank : 64)
Query Neighborhood Hits	599	Target Neighborhood Hits	812	Shared Neighborhood Hits	318
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

GABP3_MOUSE
NC score	0.420546 (rank : 60)	θ value	0.0961366 (rank : 277)
Query Neighborhood Hits	599	Target Neighborhood Hits	330	Shared Neighborhood Hits	233
SwissProt Accessions	P81069	Gene names	Gabpb2
Domain Architecture	No domain graphic available
Description	GA-binding protein beta-2-1 chain (GABP subunit beta-2-1) (GABPB2-1).

ANR23_MOUSE
NC score	0.420165 (rank : 61)	θ value	0.0252991 (rank : 216)
Query Neighborhood Hits	599	Target Neighborhood Hits	296	Shared Neighborhood Hits	229
SwissProt Accessions	Q812A3	Gene names	Ankrd23, Darp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein).

ASB8_MOUSE
NC score	0.420094 (rank : 62)	θ value	0.00134147 (rank : 128)
Query Neighborhood Hits	599	Target Neighborhood Hits	293	Shared Neighborhood Hits	229
SwissProt Accessions	Q91ZT9, Q8R178	Gene names	Asb8
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 8 (ASB-8).

ASB8_HUMAN
NC score	0.420044 (rank : 63)	θ value	0.00102713 (rank : 117)
Query Neighborhood Hits	599	Target Neighborhood Hits	294	Shared Neighborhood Hits	229
SwissProt Accessions	Q9H765, Q547Q2	Gene names	ASB8
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 8 (ASB-8).

IKBB_MOUSE
NC score	0.419477 (rank : 64)	θ value	0.000158464 (rank : 77)
Query Neighborhood Hits	599	Target Neighborhood Hits	284	Shared Neighborhood Hits	225
SwissProt Accessions	Q60778, Q9D6L5	Gene names	Nfkbib, Ikbb
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B).

MYPT1_HUMAN
NC score	0.419149 (rank : 65)	θ value	5.44631e-05 (rank : 57)
Query Neighborhood Hits	599	Target Neighborhood Hits	723	Shared Neighborhood Hits	268
SwissProt Accessions	O14974, Q86WU3, Q8NFR6, Q9BYH0	Gene names	PPP1R12A, MBS, MYPT1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit).

PA2G6_HUMAN
NC score	0.418903 (rank : 66)	θ value	0.000270298 (rank : 90)
Query Neighborhood Hits	599	Target Neighborhood Hits	284	Shared Neighborhood Hits	229
SwissProt Accessions	O60733, O75645, Q8N452, Q9UG29, Q9UIT0, Q9Y671	Gene names	PLA2G6, IPLA2
Domain Architecture
Description	85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4) (iPLA2) (CaI- PLA2) (Group VI phospholipase A2) (GVI PLA2).

GABP2_MOUSE
NC score	0.417918 (rank : 67)	θ value	0.0431538 (rank : 240)
Query Neighborhood Hits	599	Target Neighborhood Hits	429	Shared Neighborhood Hits	239
SwissProt Accessions	Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2	Gene names	Gabpb2, Gabpb, Gabpb1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1).

ANKR1_HUMAN
NC score	0.417813 (rank : 68)	θ value	0.00509761 (rank : 163)
Query Neighborhood Hits	599	Target Neighborhood Hits	308	Shared Neighborhood Hits	234
SwissProt Accessions	Q15327, Q96LE7	Gene names	ANKRD1, C193, CARP, HA1A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) (Cytokine-inducible nuclear protein) (C-193).

ASB10_HUMAN
NC score	0.417193 (rank : 69)	θ value	0.00228821 (rank : 140)
Query Neighborhood Hits	599	Target Neighborhood Hits	291	Shared Neighborhood Hits	231
SwissProt Accessions	Q8WXI3	Gene names	ASB10
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

GABP2_HUMAN
NC score	0.417118 (rank : 70)	θ value	0.0431538 (rank : 239)
Query Neighborhood Hits	599	Target Neighborhood Hits	454	Shared Neighborhood Hits	241
SwissProt Accessions	Q06547, Q06545, Q12940, Q12941, Q12942, Q8IYD0	Gene names	GABPB2, E4TF1B, GABPB, GABPB1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1) (Transcription factor E4TF1-53) (Transcription factor E4TF1-47) (Nuclear respiratory factor 2).

ANR52_MOUSE
NC score	0.416411 (rank : 71)	θ value	0.000270298 (rank : 87)
Query Neighborhood Hits	599	Target Neighborhood Hits	318	Shared Neighborhood Hits	231
SwissProt Accessions	Q8BTI7	Gene names	Ankrd52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ANK3_HUMAN
NC score	0.416312 (rank : 72)	θ value	2.36244e-08 (rank : 37)
Query Neighborhood Hits	599	Target Neighborhood Hits	853	Shared Neighborhood Hits	268
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

ANR44_HUMAN
NC score	0.416203 (rank : 73)	θ value	0.00020696 (rank : 82)
Query Neighborhood Hits	599	Target Neighborhood Hits	318	Shared Neighborhood Hits	231
SwissProt Accessions	Q8N8A2, Q6P480, Q86VL5, Q8IZ72, Q9UFA4	Gene names	ANKRD44
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 44.

ANKR2_HUMAN
NC score	0.416088 (rank : 74)	θ value	0.0252991 (rank : 214)
Query Neighborhood Hits	599	Target Neighborhood Hits	321	Shared Neighborhood Hits	235
SwissProt Accessions	Q9GZV1, Q5T456, Q8WUD7	Gene names	ANKRD2, ARPP
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp).

MYPT2_HUMAN
NC score	0.415948 (rank : 75)	θ value	0.00035302 (rank : 96)
Query Neighborhood Hits	599	Target Neighborhood Hits	707	Shared Neighborhood Hits	262
SwissProt Accessions	O60237, Q8N179, Q9HCB7, Q9HCB8	Gene names	PPP1R12B, MYPT2
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase- targeting subunit 2) (Myosin phosphatase target subunit 2).

ANS4B_MOUSE
NC score	0.415784 (rank : 76)	θ value	0.00665767 (rank : 171)
Query Neighborhood Hits	599	Target Neighborhood Hits	294	Shared Neighborhood Hits	221
SwissProt Accessions	Q8K3X6, Q9D8A5	Gene names	Anks4b, Harp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

SHAN1_HUMAN
NC score	0.415637 (rank : 77)	θ value	0.00298849 (rank : 150)
Query Neighborhood Hits	599	Target Neighborhood Hits	1041	Shared Neighborhood Hits	401
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

ANR52_HUMAN
NC score	0.415420 (rank : 78)	θ value	0.00035302 (rank : 93)
Query Neighborhood Hits	599	Target Neighborhood Hits	322	Shared Neighborhood Hits	231
SwissProt Accessions	Q8NB46	Gene names	ANKRD52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

TNKS1_HUMAN
NC score	0.414486 (rank : 79)	θ value	0.0113563 (rank : 200)
Query Neighborhood Hits	599	Target Neighborhood Hits	477	Shared Neighborhood Hits	261
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

CSKI1_HUMAN
NC score	0.414253 (rank : 80)	θ value	4.1701e-05 (rank : 52)
Query Neighborhood Hits	599	Target Neighborhood Hits	997	Shared Neighborhood Hits	350
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

ANR28_MOUSE
NC score	0.413710 (rank : 81)	θ value	0.000158464 (rank : 73)
Query Neighborhood Hits	599	Target Neighborhood Hits	314	Shared Neighborhood Hits	232
SwissProt Accessions	Q505D1	Gene names	Ankrd28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ASB10_MOUSE
NC score	0.413663 (rank : 82)	θ value	0.00509761 (rank : 166)
Query Neighborhood Hits	599	Target Neighborhood Hits	301	Shared Neighborhood Hits	231
SwissProt Accessions	Q91ZT7	Gene names	Asb10
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

ANKR2_MOUSE
NC score	0.413655 (rank : 83)	θ value	0.00869519 (rank : 180)
Query Neighborhood Hits	599	Target Neighborhood Hits	312	Shared Neighborhood Hits	232
SwissProt Accessions	Q9WV06	Gene names	Ankrd2, Arpp
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (mArpp).

CSKI1_MOUSE
NC score	0.413577 (rank : 84)	θ value	5.44631e-05 (rank : 55)
Query Neighborhood Hits	599	Target Neighborhood Hits	1031	Shared Neighborhood Hits	338
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

ANS4B_HUMAN
NC score	0.413346 (rank : 85)	θ value	0.00509761 (rank : 165)
Query Neighborhood Hits	599	Target Neighborhood Hits	289	Shared Neighborhood Hits	222
SwissProt Accessions	Q8N8V4	Gene names	ANKS4B, HARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

ANR28_HUMAN
NC score	0.412213 (rank : 86)	θ value	0.000461057 (rank : 99)
Query Neighborhood Hits	599	Target Neighborhood Hits	314	Shared Neighborhood Hits	232
SwissProt Accessions	O15084, Q6ULS0, Q6ZT57	Gene names	ANKRD28, KIAA0379
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ASB16_HUMAN
NC score	0.409722 (rank : 87)	θ value	0.00035302 (rank : 94)
Query Neighborhood Hits	599	Target Neighborhood Hits	286	Shared Neighborhood Hits	228
SwissProt Accessions	Q96NS5, Q8WXK0	Gene names	ASB16
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 16 (ASB-16).

ASB16_MOUSE
NC score	0.408905 (rank : 88)	θ value	0.000786445 (rank : 112)
Query Neighborhood Hits	599	Target Neighborhood Hits	306	Shared Neighborhood Hits	229
SwissProt Accessions	Q8VHS5, Q8BYT0	Gene names	Asb16
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 16 (ASB-16).

BCL3_HUMAN
NC score	0.407110 (rank : 89)	θ value	0.00665767 (rank : 172)
Query Neighborhood Hits	599	Target Neighborhood Hits	324	Shared Neighborhood Hits	236
SwissProt Accessions	P20749	Gene names	BCL3
Domain Architecture
Description	B-cell lymphoma 3-encoded protein (Protein Bcl-3).

TNKS2_HUMAN
NC score	0.406885 (rank : 90)	θ value	0.0252991 (rank : 224)
Query Neighborhood Hits	599	Target Neighborhood Hits	361	Shared Neighborhood Hits	236
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

ANR41_HUMAN
NC score	0.406636 (rank : 91)	θ value	0.0961366 (rank : 275)
Query Neighborhood Hits	599	Target Neighborhood Hits	332	Shared Neighborhood Hits	219
SwissProt Accessions	Q8NAG6, Q8N8J8	Gene names	ANKRD41
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 41.

ASB2_HUMAN
NC score	0.405627 (rank : 92)	θ value	0.000270298 (rank : 88)
Query Neighborhood Hits	599	Target Neighborhood Hits	309	Shared Neighborhood Hits	229
SwissProt Accessions	Q96Q27, Q9NSU5, Q9Y567	Gene names	ASB2
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 2 (ASB-2).

USH1G_MOUSE
NC score	0.404326 (rank : 93)	θ value	0.00869519 (rank : 189)
Query Neighborhood Hits	599	Target Neighborhood Hits	271	Shared Neighborhood Hits	222
SwissProt Accessions	Q80T11, Q80UG0	Gene names	Ush1g, Sans
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein homolog (Scaffold protein containing ankyrin repeats and SAM domain) (Jackson shaker protein).

USH1G_HUMAN
NC score	0.403956 (rank : 94)	θ value	0.00869519 (rank : 188)
Query Neighborhood Hits	599	Target Neighborhood Hits	267	Shared Neighborhood Hits	222
SwissProt Accessions	Q495M9, Q8N251	Gene names	USH1G, SANS
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein (Scaffold protein containing ankyrin repeats and SAM domain).

ANR50_HUMAN
NC score	0.403816 (rank : 95)	θ value	0.163984 (rank : 305)
Query Neighborhood Hits	599	Target Neighborhood Hits	361	Shared Neighborhood Hits	229
SwissProt Accessions	Q9ULJ7, Q6N064, Q6ZSE6	Gene names	ANKRD50, KIAA1223
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 50.

BCL3_MOUSE
NC score	0.403277 (rank : 96)	θ value	0.00665767 (rank : 173)
Query Neighborhood Hits	599	Target Neighborhood Hits	388	Shared Neighborhood Hits	238
SwissProt Accessions	Q9Z2F6	Gene names	Bcl3
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 3-encoded protein homolog (Protein Bcl-3).

ASB3_MOUSE
NC score	0.402544 (rank : 97)	θ value	0.00298849 (rank : 147)
Query Neighborhood Hits	599	Target Neighborhood Hits	316	Shared Neighborhood Hits	229
SwissProt Accessions	Q9WV72	Gene names	Asb3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

ANR49_HUMAN
NC score	0.401800 (rank : 98)	θ value	0.0563607 (rank : 249)
Query Neighborhood Hits	599	Target Neighborhood Hits	282	Shared Neighborhood Hits	228
SwissProt Accessions	Q8WVL7, Q8NDF2, Q96JE5, Q9NXK7	Gene names	ANKRD49, FGIF
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor).

IKBE_MOUSE
NC score	0.401702 (rank : 99)	θ value	0.00228821 (rank : 142)
Query Neighborhood Hits	599	Target Neighborhood Hits	308	Shared Neighborhood Hits	233
SwissProt Accessions	O54910, Q3U686, Q9CZZ9, Q9D7U3	Gene names	Nfkbie, Ikbe
Domain Architecture
Description	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKB-E).

ANR29_HUMAN
NC score	0.401509 (rank : 100)	θ value	0.163984 (rank : 304)
Query Neighborhood Hits	599	Target Neighborhood Hits	294	Shared Neighborhood Hits	227
SwissProt Accessions	Q8N6D5, Q6ZWE8, Q96LU9	Gene names	ANKRD29
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 29.

MTPN_MOUSE
NC score	0.400822 (rank : 101)	θ value	θ > 10 (rank : 696)
Query Neighborhood Hits	599	Target Neighborhood Hits	269	Shared Neighborhood Hits	223
SwissProt Accessions	P62774, P80144, Q543M6, Q9DCN8	Gene names	Mtpn, Gcdp
Domain Architecture	No domain graphic available
Description	Myotrophin (Protein V-1) (Granule cell differentiation protein).

IKBB_HUMAN
NC score	0.400745 (rank : 102)	θ value	0.00298849 (rank : 149)
Query Neighborhood Hits	599	Target Neighborhood Hits	284	Shared Neighborhood Hits	229
SwissProt Accessions	Q15653, Q96BJ7	Gene names	NFKBIB, IKBB, TRIP9
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9).

INVS_HUMAN
NC score	0.400488 (rank : 103)	θ value	0.0113563 (rank : 195)
Query Neighborhood Hits	599	Target Neighborhood Hits	455	Shared Neighborhood Hits	247
SwissProt Accessions	Q9Y283, Q5W0T6, Q8IVX8, Q9BRB9, Q9Y488, Q9Y498	Gene names	INVS, INV, NPHP2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning homolog) (Nephrocystin-2).

ASB13_MOUSE
NC score	0.400001 (rank : 104)	θ value	0.125558 (rank : 288)
Query Neighborhood Hits	599	Target Neighborhood Hits	293	Shared Neighborhood Hits	227
SwissProt Accessions	Q8VBX0	Gene names	Asb13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 13 (ASB-13).

INVS_MOUSE
NC score	0.399988 (rank : 105)	θ value	0.00869519 (rank : 185)
Query Neighborhood Hits	599	Target Neighborhood Hits	609	Shared Neighborhood Hits	259
SwissProt Accessions	O89019, O88849	Gene names	Invs, Inv, Nphp2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning protein) (Nephrocystin-2).

ANK2_HUMAN
NC score	0.399939 (rank : 106)	θ value	3.77169e-06 (rank : 44)
Query Neighborhood Hits	599	Target Neighborhood Hits	1615	Shared Neighborhood Hits	333
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

ASB3_HUMAN
NC score	0.399704 (rank : 107)	θ value	0.00390308 (rank : 154)
Query Neighborhood Hits	599	Target Neighborhood Hits	316	Shared Neighborhood Hits	228
SwissProt Accessions	Q9Y575, Q9NVZ2	Gene names	ASB3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

ASB13_HUMAN
NC score	0.399543 (rank : 108)	θ value	0.125558 (rank : 287)
Query Neighborhood Hits	599	Target Neighborhood Hits	293	Shared Neighborhood Hits	226
SwissProt Accessions	Q8WXK3, Q96EP7, Q9H8Z1	Gene names	ASB13
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 13 (ASB-13).

ASB2_MOUSE
NC score	0.399026 (rank : 109)	θ value	0.00020696 (rank : 83)
Query Neighborhood Hits	599	Target Neighborhood Hits	321	Shared Neighborhood Hits	230
SwissProt Accessions	Q8K0L0, Q9CTH4, Q9WV73	Gene names	Asb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 2 (ASB-2).

ASB7_HUMAN
NC score	0.398955 (rank : 110)	θ value	0.62314 (rank : 370)
Query Neighborhood Hits	599	Target Neighborhood Hits	296	Shared Neighborhood Hits	228
SwissProt Accessions	Q9H672, Q7Z4S3	Gene names	ASB7
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 7 (ASB-7).

ASB7_MOUSE
NC score	0.398904 (rank : 111)	θ value	0.62314 (rank : 371)
Query Neighborhood Hits	599	Target Neighborhood Hits	296	Shared Neighborhood Hits	228
SwissProt Accessions	Q91ZU0	Gene names	Asb7
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 7 (ASB-7).

FANK1_MOUSE
NC score	0.398898 (rank : 112)	θ value	0.0113563 (rank : 194)
Query Neighborhood Hits	599	Target Neighborhood Hits	325	Shared Neighborhood Hits	230
SwissProt Accessions	Q9DAM9, Q9CUA7	Gene names	Fank1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains 1 protein (Germ cell- specific gene 1 protein) (GSG1).

ANRA2_HUMAN
NC score	0.398724 (rank : 113)	θ value	0.0148317 (rank : 202)
Query Neighborhood Hits	599	Target Neighborhood Hits	288	Shared Neighborhood Hits	225
SwissProt Accessions	Q9H9E1	Gene names	ANKRA2, ANKRA
Domain Architecture
Description	Ankyrin repeat family A protein 2 (RFXANK-like 2).

ANRA2_MOUSE
NC score	0.397624 (rank : 114)	θ value	0.0330416 (rank : 227)
Query Neighborhood Hits	599	Target Neighborhood Hits	287	Shared Neighborhood Hits	225
SwissProt Accessions	Q99PE2	Gene names	Ankra2, Ankra
Domain Architecture
Description	Ankyrin repeat family A protein 2 (RFXANK-like 2).

PP16A_MOUSE
NC score	0.397252 (rank : 115)	θ value	0.0252991 (rank : 222)
Query Neighborhood Hits	599	Target Neighborhood Hits	318	Shared Neighborhood Hits	231
SwissProt Accessions	Q923M0, Q4V9Z1	Gene names	Ppp1r16a, Mypt3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase targeting subunit 3).

ANKR5_MOUSE
NC score	0.396317 (rank : 116)	θ value	0.0563607 (rank : 248)
Query Neighborhood Hits	599	Target Neighborhood Hits	298	Shared Neighborhood Hits	229
SwissProt Accessions	Q9D2J7	Gene names	Ankrd5
Domain Architecture
Description	Ankyrin repeat domain-containing protein 5.

FANK1_HUMAN
NC score	0.396171 (rank : 117)	θ value	0.0563607 (rank : 253)
Query Neighborhood Hits	599	Target Neighborhood Hits	326	Shared Neighborhood Hits	231
SwissProt Accessions	Q8TC84, Q6UXY9, Q6X7T6	Gene names	FANK1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains protein 1.

MTPN_HUMAN
NC score	0.394963 (rank : 118)	θ value	θ > 10 (rank : 695)
Query Neighborhood Hits	599	Target Neighborhood Hits	269	Shared Neighborhood Hits	223
SwissProt Accessions	P58546	Gene names	MTPN
Domain Architecture
Description	Myotrophin (Protein V-1).

ANR49_MOUSE
NC score	0.394469 (rank : 119)	θ value	0.125558 (rank : 285)
Query Neighborhood Hits	599	Target Neighborhood Hits	285	Shared Neighborhood Hits	227
SwissProt Accessions	Q8VE42, Q9Z2S1	Gene names	Ankrd49, Fgif, Gbif
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor) (Fetal globin-increasing factor).

ANKR5_HUMAN
NC score	0.394294 (rank : 120)	θ value	0.0961366 (rank : 273)
Query Neighborhood Hits	599	Target Neighborhood Hits	297	Shared Neighborhood Hits	228
SwissProt Accessions	Q9NU02, Q9H6Y9	Gene names	ANKRD5
Domain Architecture
Description	Ankyrin repeat domain-containing protein 5.

TRPA1_MOUSE
NC score	0.394263 (rank : 121)	θ value	0.000270298 (rank : 92)
Query Neighborhood Hits	599	Target Neighborhood Hits	343	Shared Neighborhood Hits	232
SwissProt Accessions	Q8BLA8	Gene names	Trpa1, Anktm1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1).

BARD1_HUMAN
NC score	0.393119 (rank : 122)	θ value	0.00298849 (rank : 148)
Query Neighborhood Hits	599	Target Neighborhood Hits	427	Shared Neighborhood Hits	228
SwissProt Accessions	Q99728, O43574	Gene names	BARD1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

PP16B_HUMAN
NC score	0.393105 (rank : 123)	θ value	0.00665767 (rank : 177)
Query Neighborhood Hits	599	Target Neighborhood Hits	307	Shared Neighborhood Hits	230
SwissProt Accessions	Q96T49, O94912, Q9NQG4	Gene names	PPP1R16B, ANKRD4, KIAA0823
Domain Architecture
Description	Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein) (hTIMAP) (CAAX box protein TIMAP) (Ankyrin repeat domain protein 4).

PP16B_MOUSE
NC score	0.392986 (rank : 124)	θ value	0.00665767 (rank : 178)
Query Neighborhood Hits	599	Target Neighborhood Hits	302	Shared Neighborhood Hits	229
SwissProt Accessions	Q8VHQ3	Gene names	Ppp1r16b
Domain Architecture
Description	Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein) (CAAX box protein TIMAP).

ANR35_HUMAN
NC score	0.390083 (rank : 125)	θ value	0.00228821 (rank : 139)
Query Neighborhood Hits	599	Target Neighborhood Hits	784	Shared Neighborhood Hits	271
SwissProt Accessions	Q8N283, Q3MJ10, Q96LS3	Gene names	ANKRD35
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 35.

AN36B_HUMAN
NC score	0.389949 (rank : 126)	θ value	0.000158464 (rank : 72)
Query Neighborhood Hits	599	Target Neighborhood Hits	294	Shared Neighborhood Hits	227
SwissProt Accessions	Q8N2N9, Q6IPR0	Gene names	ANKRD36B
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 36B.

MIB1_MOUSE
NC score	0.388066 (rank : 127)	θ value	0.000121331 (rank : 69)
Query Neighborhood Hits	599	Target Neighborhood Hits	471	Shared Neighborhood Hits	235
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

MIB1_HUMAN
NC score	0.387982 (rank : 128)	θ value	0.000121331 (rank : 68)
Query Neighborhood Hits	599	Target Neighborhood Hits	470	Shared Neighborhood Hits	234
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

IASPP_HUMAN
NC score	0.387923 (rank : 129)	θ value	0.0961366 (rank : 278)
Query Neighborhood Hits	599	Target Neighborhood Hits	688	Shared Neighborhood Hits	382
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

AN36A_HUMAN
NC score	0.387264 (rank : 130)	θ value	0.000602161 (rank : 102)
Query Neighborhood Hits	599	Target Neighborhood Hits	271	Shared Neighborhood Hits	224
SwissProt Accessions	Q6UX02, Q86X62	Gene names	ANKRD36, ANKRD36A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 36A.

BARD1_MOUSE
NC score	0.387139 (rank : 131)	θ value	0.00869519 (rank : 181)
Query Neighborhood Hits	599	Target Neighborhood Hits	411	Shared Neighborhood Hits	228
SwissProt Accessions	O70445	Gene names	Bard1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

MIB2_HUMAN
NC score	0.387049 (rank : 132)	θ value	0.0961366 (rank : 279)
Query Neighborhood Hits	599	Target Neighborhood Hits	438	Shared Neighborhood Hits	232
SwissProt Accessions	Q96AX9, Q7Z437, Q8IY62, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1	Gene names	MIB2, SKD, ZZANK1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N).

ACBD6_MOUSE
NC score	0.385579 (rank : 133)	θ value	0.0431538 (rank : 237)
Query Neighborhood Hits	599	Target Neighborhood Hits	305	Shared Neighborhood Hits	229
SwissProt Accessions	Q9D061, Q3TMN7, Q9DCU4	Gene names	Acbd6
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 6.

MIB2_MOUSE
NC score	0.385204 (rank : 134)	θ value	0.0330416 (rank : 233)
Query Neighborhood Hits	599	Target Neighborhood Hits	409	Shared Neighborhood Hits	230
SwissProt Accessions	Q8R516, Q52QU8, Q6PEF6, Q8C1N7, Q8VIB4	Gene names	Mib2, Skd
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) (Dystrophin-like protein) (Dyslike).

PP16A_HUMAN
NC score	0.384746 (rank : 135)	θ value	0.00390308 (rank : 161)
Query Neighborhood Hits	599	Target Neighborhood Hits	340	Shared Neighborhood Hits	235
SwissProt Accessions	Q96I34	Gene names	PPP1R16A, MYPT3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase- targeting subunit 3).

IKBE_HUMAN
NC score	0.384135 (rank : 136)	θ value	0.125558 (rank : 293)
Query Neighborhood Hits	599	Target Neighborhood Hits	288	Shared Neighborhood Hits	225
SwissProt Accessions	O00221	Gene names	NFKBIE, IKBE
Domain Architecture
Description	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKBE).

ACBD6_HUMAN
NC score	0.384101 (rank : 137)	θ value	0.0330416 (rank : 225)
Query Neighborhood Hits	599	Target Neighborhood Hits	304	Shared Neighborhood Hits	227
SwissProt Accessions	Q9BR61	Gene names	ACBD6
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 6.

EHMT1_HUMAN
NC score	0.384047 (rank : 138)	θ value	0.00869519 (rank : 183)
Query Neighborhood Hits	599	Target Neighborhood Hits	417	Shared Neighborhood Hits	234
SwissProt Accessions	Q9H9B1, Q8TCN7, Q96F53, Q96JF1, Q96KH4	Gene names	EHMT1, EUHMTASE1, KIAA1876
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a- like protein 1) (GLP1).

TRPA1_HUMAN
NC score	0.383842 (rank : 139)	θ value	0.0961366 (rank : 283)
Query Neighborhood Hits	599	Target Neighborhood Hits	339	Shared Neighborhood Hits	231
SwissProt Accessions	O75762	Gene names	TRPA1, ANKTM1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation sensitive-protein p120).

EHMT2_HUMAN
NC score	0.382013 (rank : 140)	θ value	0.00869519 (rank : 184)
Query Neighborhood Hits	599	Target Neighborhood Hits	498	Shared Neighborhood Hits	242
SwissProt Accessions	Q96KQ7, Q14349, Q6PK06, Q96MH5, Q96QD0, Q9UQL8, Q9Y331	Gene names	EHMT2, BAT8, G9A, NG36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

ANKS3_MOUSE
NC score	0.380413 (rank : 141)	θ value	0.125558 (rank : 284)
Query Neighborhood Hits	599	Target Neighborhood Hits	355	Shared Neighborhood Hits	229
SwissProt Accessions	Q9CZK6, Q6ZPF6, Q80X46	Gene names	Anks3, Kiaa1977
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 3.

NUPL_HUMAN
NC score	0.377158 (rank : 142)	θ value	0.00134147 (rank : 131)
Query Neighborhood Hits	599	Target Neighborhood Hits	68	Shared Neighborhood Hits	38
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).

ANR19_HUMAN
NC score	0.376533 (rank : 143)	θ value	0.0736092 (rank : 263)
Query Neighborhood Hits	599	Target Neighborhood Hits	276	Shared Neighborhood Hits	222
SwissProt Accessions	Q9H560	Gene names	ANKRD19
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 19.

ASB11_MOUSE
NC score	0.376493 (rank : 144)	θ value	0.0330416 (rank : 228)
Query Neighborhood Hits	599	Target Neighborhood Hits	271	Shared Neighborhood Hits	221
SwissProt Accessions	Q9CQ31, Q3UJ13, Q9D0V1	Gene names	Asb11
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 11 (ASB-11).

ANKS1_HUMAN
NC score	0.376391 (rank : 145)	θ value	0.365318 (rank : 348)
Query Neighborhood Hits	599	Target Neighborhood Hits	438	Shared Neighborhood Hits	236
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

ANKR7_HUMAN
NC score	0.376330 (rank : 146)	θ value	6.88961 (rank : 530)
Query Neighborhood Hits	599	Target Neighborhood Hits	286	Shared Neighborhood Hits	227
SwissProt Accessions	Q92527, Q96QN1, Q9UDM3	Gene names	ANKRD7
Domain Architecture
Description	Ankyrin repeat domain-containing protein 7 (Testis-specific protein TSA806).

ASZ1_MOUSE
NC score	0.376273 (rank : 147)	θ value	0.0330416 (rank : 230)
Query Neighborhood Hits	599	Target Neighborhood Hits	319	Shared Neighborhood Hits	230
SwissProt Accessions	Q8VD46, Q9JKQ7	Gene names	Asz1, Gasz
Domain Architecture
Description	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).

RFXK_HUMAN
NC score	0.375563 (rank : 148)	θ value	0.0431538 (rank : 245)
Query Neighborhood Hits	599	Target Neighborhood Hits	282	Shared Neighborhood Hits	225
SwissProt Accessions	O14593, O95839	Gene names	RFXANK, ANKRA1, RFXB
Domain Architecture
Description	DNA-binding protein RFXANK (Regulatory factor X subunit B) (RFX-B) (Ankyrin repeat family A protein 1).

ASB4_MOUSE
NC score	0.375142 (rank : 149)	θ value	0.0563607 (rank : 251)
Query Neighborhood Hits	599	Target Neighborhood Hits	265	Shared Neighborhood Hits	222
SwissProt Accessions	Q9WV71	Gene names	Asb4
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 4 (ASB-4).

ASB15_HUMAN
NC score	0.374155 (rank : 150)	θ value	0.0563607 (rank : 250)
Query Neighborhood Hits	599	Target Neighborhood Hits	305	Shared Neighborhood Hits	228
SwissProt Accessions	Q8WXK1	Gene names	ASB15
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 15 (ASB-15).

NUPL_MOUSE
NC score	0.373839 (rank : 151)	θ value	0.00134147 (rank : 132)
Query Neighborhood Hits	599	Target Neighborhood Hits	113	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K2K6, O70448, Q8BQL5, Q8CDK9	Gene names	Hrb, Rip
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein homolog).

ANR45_MOUSE
NC score	0.373513 (rank : 152)	θ value	0.000461057 (rank : 100)
Query Neighborhood Hits	599	Target Neighborhood Hits	204	Shared Neighborhood Hits	170
SwissProt Accessions	Q810N6	Gene names	Ankrd45
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 45.

EHMT2_MOUSE
NC score	0.373234 (rank : 153)	θ value	0.0252991 (rank : 219)
Query Neighborhood Hits	599	Target Neighborhood Hits	750	Shared Neighborhood Hits	266
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

ANKS6_HUMAN
NC score	0.373211 (rank : 154)	θ value	1.06291 (rank : 400)
Query Neighborhood Hits	599	Target Neighborhood Hits	411	Shared Neighborhood Hits	246
SwissProt Accessions	Q68DC2, Q5VSL0, Q5VSL2, Q5VSL3, Q5VSL4, Q68DB8, Q6P2R2, Q8N9L6, Q96D62	Gene names	ANKS6, ANKRD14, SAMD6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6) (Ankyrin repeat domain-containing protein 14).

POTE8_HUMAN
NC score	0.373015 (rank : 155)	θ value	0.0431538 (rank : 243)
Query Neighborhood Hits	599	Target Neighborhood Hits	337	Shared Neighborhood Hits	229
SwissProt Accessions	Q6S8J7, Q6S8J6	Gene names	POTE8
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 8.

ANKS1_MOUSE
NC score	0.372795 (rank : 156)	θ value	0.0252991 (rank : 215)
Query Neighborhood Hits	599	Target Neighborhood Hits	453	Shared Neighborhood Hits	242
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

ASB4_HUMAN
NC score	0.370768 (rank : 157)	θ value	0.365318 (rank : 350)
Query Neighborhood Hits	599	Target Neighborhood Hits	264	Shared Neighborhood Hits	222
SwissProt Accessions	Q9Y574, O14586	Gene names	ASB4
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 4 (ASB-4).

ANKS3_HUMAN
NC score	0.370713 (rank : 158)	θ value	0.62314 (rank : 368)
Query Neighborhood Hits	599	Target Neighborhood Hits	355	Shared Neighborhood Hits	233
SwissProt Accessions	Q6ZW76, Q8TF25	Gene names	ANKS3, KIAA1977
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 3.

ZDH17_HUMAN
NC score	0.370102 (rank : 159)	θ value	0.00228821 (rank : 145)
Query Neighborhood Hits	599	Target Neighborhood Hits	334	Shared Neighborhood Hits	229
SwissProt Accessions	Q8IUH5, O75407, Q7Z2I0, Q86W89, Q86YK0, Q9P088, Q9UPZ8	Gene names	ZDHHC17, HIP14, HIP3, KIAA0946
Domain Architecture
Description	Palmitoyltransferase ZDHHC17 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 17) (DHHC-17) (Huntingtin-interacting protein 14) (Huntingtin-interacting protein 3) (Huntingtin-interacting protein HYPH) (Putative NF-kappa-B-activating protein 205) (Putative MAPK- activating protein PM11).

ASB11_HUMAN
NC score	0.370099 (rank : 160)	θ value	0.125558 (rank : 286)
Query Neighborhood Hits	599	Target Neighborhood Hits	271	Shared Neighborhood Hits	221
SwissProt Accessions	Q8WXH4, Q3SYC4	Gene names	ASB11
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 11 (ASB-11).

ANR16_HUMAN
NC score	0.369698 (rank : 161)	θ value	8.99809 (rank : 562)
Query Neighborhood Hits	599	Target Neighborhood Hits	286	Shared Neighborhood Hits	228
SwissProt Accessions	Q6P6B7, Q9NT01	Gene names	ANKRD16
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 16.

CTTB2_HUMAN
NC score	0.369678 (rank : 162)	θ value	0.0148317 (rank : 206)
Query Neighborhood Hits	599	Target Neighborhood Hits	1061	Shared Neighborhood Hits	302
SwissProt Accessions	Q8WZ74, O43389, Q7LG11, Q9C0A5	Gene names	CTTNBP2, C7orf8, CORTBP2, KIAA1758
Domain Architecture	No domain graphic available
Description	Cortactin-binding protein 2 (CortBP2).

CDN2D_HUMAN
NC score	0.369246 (rank : 163)	θ value	θ > 10 (rank : 650)
Query Neighborhood Hits	599	Target Neighborhood Hits	268	Shared Neighborhood Hits	218
SwissProt Accessions	P55273, Q13102, Q6FGE9	Gene names	CDKN2D
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

ASZ1_HUMAN
NC score	0.368213 (rank : 164)	θ value	0.125558 (rank : 290)
Query Neighborhood Hits	599	Target Neighborhood Hits	341	Shared Neighborhood Hits	234
SwissProt Accessions	Q8WWH4	Gene names	ASZ1, GASZ
Domain Architecture
Description	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).

RFXK_MOUSE
NC score	0.368191 (rank : 165)	θ value	0.163984 (rank : 314)
Query Neighborhood Hits	599	Target Neighborhood Hits	273	Shared Neighborhood Hits	227
SwissProt Accessions	Q9Z205	Gene names	Rfxank, Rfxb, Tvl1
Domain Architecture
Description	DNA-binding protein RFXANK (Regulatory factor X subunit B) (RFX-B) (Regulatory factor X-associated ankyrin-containing protein) (Ankyrin repeat-containing adapter protein Tvl-1).

ZDH17_MOUSE
NC score	0.367233 (rank : 166)	θ value	0.00509761 (rank : 169)
Query Neighborhood Hits	599	Target Neighborhood Hits	328	Shared Neighborhood Hits	229
SwissProt Accessions	Q80TN5, Q8BJ08, Q8BYQ2, Q8BYQ6	Gene names	Zdhhc17, Hip14, Kiaa0946
Domain Architecture
Description	Palmitoyltransferase ZDHHC17 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 17) (DHHC-17) (Huntingtin-interacting protein 14).

SNCAP_HUMAN
NC score	0.366989 (rank : 167)	θ value	0.0431538 (rank : 246)
Query Neighborhood Hits	599	Target Neighborhood Hits	313	Shared Neighborhood Hits	217
SwissProt Accessions	Q9Y6H5	Gene names	SNCAIP
Domain Architecture
Description	Synphilin-1 (Alpha-synuclein-interacting protein).

ASB5_HUMAN
NC score	0.366826 (rank : 168)	θ value	0.0961366 (rank : 276)
Query Neighborhood Hits	599	Target Neighborhood Hits	283	Shared Neighborhood Hits	224
SwissProt Accessions	Q8WWX0	Gene names	ASB5
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 5 (ASB-5).

CDN2C_HUMAN
NC score	0.366465 (rank : 169)	θ value	6.88961 (rank : 536)
Query Neighborhood Hits	599	Target Neighborhood Hits	262	Shared Neighborhood Hits	221
SwissProt Accessions	P42773, Q8TB83	Gene names	CDKN2C, CDKN6
Domain Architecture
Description	Cyclin-dependent kinase 6 inhibitor (p18-INK6) (Cyclin-dependent kinase 4 inhibitor C) (p18-INK4c).

ANKS6_MOUSE
NC score	0.366176 (rank : 170)	θ value	6.88961 (rank : 531)
Query Neighborhood Hits	599	Target Neighborhood Hits	435	Shared Neighborhood Hits	245
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

ASB15_MOUSE
NC score	0.365536 (rank : 171)	θ value	0.0330416 (rank : 229)
Query Neighborhood Hits	599	Target Neighborhood Hits	292	Shared Neighborhood Hits	224
SwissProt Accessions	Q8VHS6	Gene names	Asb15
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 15 (ASB-15).

IKBA_HUMAN
NC score	0.365338 (rank : 172)	θ value	4.03905 (rank : 495)
Query Neighborhood Hits	599	Target Neighborhood Hits	280	Shared Neighborhood Hits	227
SwissProt Accessions	P25963	Gene names	NFKBIA, IKBA, MAD3, NFKBI
Domain Architecture
Description	NF-kappa-B inhibitor alpha (Major histocompatibility complex enhancer- binding protein MAD3) (I-kappa-B-alpha) (IkappaBalpha) (IKB-alpha).

CDN2C_MOUSE
NC score	0.365282 (rank : 173)	θ value	θ > 10 (rank : 649)
Query Neighborhood Hits	599	Target Neighborhood Hits	270	Shared Neighborhood Hits	222
SwissProt Accessions	Q60772	Gene names	Cdkn2c
Domain Architecture
Description	Cyclin-dependent kinase 6 inhibitor (p18-INK6) (Cyclin-dependent kinase 4 inhibitor C) (p18-INK4c).

ASB14_MOUSE
NC score	0.364852 (rank : 174)	θ value	1.38821 (rank : 415)
Query Neighborhood Hits	599	Target Neighborhood Hits	293	Shared Neighborhood Hits	228
SwissProt Accessions	Q8VHS7	Gene names	Asb14
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 14 (ASB-14).

ASB9_HUMAN
NC score	0.364434 (rank : 175)	θ value	2.36792 (rank : 443)
Query Neighborhood Hits	599	Target Neighborhood Hits	267	Shared Neighborhood Hits	218
SwissProt Accessions	Q96DX5, Q9NWS5, Q9Y4T3	Gene names	ASB9
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 9 (ASB-9).

IASPP_MOUSE
NC score	0.361051 (rank : 176)	θ value	0.0736092 (rank : 266)
Query Neighborhood Hits	599	Target Neighborhood Hits	1024	Shared Neighborhood Hits	379
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ASB5_MOUSE
NC score	0.359552 (rank : 177)	θ value	0.279714 (rank : 339)
Query Neighborhood Hits	599	Target Neighborhood Hits	266	Shared Neighborhood Hits	218
SwissProt Accessions	Q9D1A4	Gene names	Asb5
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 5 (ASB-5).

CDN2D_MOUSE
NC score	0.359427 (rank : 178)	θ value	θ > 10 (rank : 651)
Query Neighborhood Hits	599	Target Neighborhood Hits	267	Shared Neighborhood Hits	217
SwissProt Accessions	Q60773, Q60794	Gene names	Cdkn2d
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

ASPP1_HUMAN
NC score	0.359268 (rank : 179)	θ value	0.365318 (rank : 351)
Query Neighborhood Hits	599	Target Neighborhood Hits	956	Shared Neighborhood Hits	404
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ZDH13_MOUSE
NC score	0.358210 (rank : 180)	θ value	0.00035302 (rank : 98)
Query Neighborhood Hits	599	Target Neighborhood Hits	329	Shared Neighborhood Hits	229
SwissProt Accessions	Q9CWU2, Q3UK32, Q3UKV1	Gene names	Zdhhc13, Hip14l
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC13 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein).

RN5A_HUMAN
NC score	0.358030 (rank : 181)	θ value	0.21417 (rank : 331)
Query Neighborhood Hits	599	Target Neighborhood Hits	608	Shared Neighborhood Hits	240
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

ASPP1_MOUSE
NC score	0.357922 (rank : 182)	θ value	0.125558 (rank : 289)
Query Neighborhood Hits	599	Target Neighborhood Hits	1244	Shared Neighborhood Hits	418
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASB9_MOUSE
NC score	0.356892 (rank : 183)	θ value	θ > 10 (rank : 640)
Query Neighborhood Hits	599	Target Neighborhood Hits	257	Shared Neighborhood Hits	211
SwissProt Accessions	Q91ZT8, Q9DAF7	Gene names	Asb9
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 9 (ASB-9).

IKBA_MOUSE
NC score	0.355511 (rank : 184)	θ value	6.88961 (rank : 539)
Query Neighborhood Hits	599	Target Neighborhood Hits	283	Shared Neighborhood Hits	226
SwissProt Accessions	Q9Z1E3, Q80ZX5	Gene names	Nfkbia, Ikba
Domain Architecture	No domain graphic available
Description	NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkappaBalpha) (IKB- alpha).

ZDH13_HUMAN
NC score	0.354395 (rank : 185)	θ value	0.00390308 (rank : 162)
Query Neighborhood Hits	599	Target Neighborhood Hits	322	Shared Neighborhood Hits	228
SwissProt Accessions	Q8IUH4, Q7Z2D3, Q86VK2, Q9NV30, Q9NV99	Gene names	ZDHHC13, HIP14L, HIP3RP
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC13 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein) (Huntingtin- interacting protein HIP3RP) (Putative NF-kappa-B-activating protein 209) (Putative MAPK-activating protein PM03).

ASB1_HUMAN
NC score	0.353258 (rank : 186)	θ value	0.813845 (rank : 388)
Query Neighborhood Hits	599	Target Neighborhood Hits	291	Shared Neighborhood Hits	224
SwissProt Accessions	Q9Y576, Q9ULS4	Gene names	ASB1, KIAA1146
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 1 (ASB-1).

ANR21_HUMAN
NC score	0.352487 (rank : 187)	θ value	0.163984 (rank : 303)
Query Neighborhood Hits	599	Target Neighborhood Hits	864	Shared Neighborhood Hits	266
SwissProt Accessions	Q86YR6	Gene names	ANKRD21, POTE
Domain Architecture
Description	Ankyrin repeat domain-containing protein 21 (Protein POTE) (Prostate, ovary, testis-expressed protein).

POT15_HUMAN
NC score	0.351601 (rank : 188)	θ value	0.125558 (rank : 295)
Query Neighborhood Hits	599	Target Neighborhood Hits	893	Shared Neighborhood Hits	275
SwissProt Accessions	Q6S5H4, Q6NXN7, Q6S5H7	Gene names	POTE15
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 15.

ANFY1_MOUSE
NC score	0.351417 (rank : 189)	θ value	0.279714 (rank : 338)
Query Neighborhood Hits	599	Target Neighborhood Hits	480	Shared Neighborhood Hits	235
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_HUMAN
NC score	0.351326 (rank : 190)	θ value	0.813845 (rank : 383)
Query Neighborhood Hits	599	Target Neighborhood Hits	480	Shared Neighborhood Hits	235
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ASB1_MOUSE
NC score	0.350569 (rank : 191)	θ value	1.38821 (rank : 416)
Query Neighborhood Hits	599	Target Neighborhood Hits	292	Shared Neighborhood Hits	222
SwissProt Accessions	Q9WV74	Gene names	Asb1
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 1 (ASB-1).

ASPP2_HUMAN
NC score	0.349734 (rank : 192)	θ value	3.0926 (rank : 465)
Query Neighborhood Hits	599	Target Neighborhood Hits	1156	Shared Neighborhood Hits	392
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

ASB12_HUMAN
NC score	0.347992 (rank : 193)	θ value	θ > 10 (rank : 635)
Query Neighborhood Hits	599	Target Neighborhood Hits	263	Shared Neighborhood Hits	218
SwissProt Accessions	Q8WXK4, Q52LK4, Q6ISF9	Gene names	ASB12
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 12 (ASB-12).

ASB12_MOUSE
NC score	0.347016 (rank : 194)	θ value	θ > 10 (rank : 636)
Query Neighborhood Hits	599	Target Neighborhood Hits	261	Shared Neighborhood Hits	218
SwissProt Accessions	Q9D738	Gene names	Asb12
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 12 (ASB-12).

POT14_HUMAN
NC score	0.345985 (rank : 195)	θ value	0.365318 (rank : 358)
Query Neighborhood Hits	599	Target Neighborhood Hits	403	Shared Neighborhood Hits	231
SwissProt Accessions	Q6S5H5, Q6S5H6, Q6S8J2	Gene names	POTE14
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 14.

ANR45_HUMAN
NC score	0.344798 (rank : 196)	θ value	0.00665767 (rank : 170)
Query Neighborhood Hits	599	Target Neighborhood Hits	201	Shared Neighborhood Hits	165
SwissProt Accessions	Q5TZF3, Q6ZST1	Gene names	ANKRD45
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 45.

ANR11_HUMAN
NC score	0.342647 (rank : 197)	θ value	3.0926 (rank : 463)
Query Neighborhood Hits	599	Target Neighborhood Hits	1289	Shared Neighborhood Hits	314
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

ANR15_HUMAN
NC score	0.340683 (rank : 198)	θ value	0.365318 (rank : 349)
Query Neighborhood Hits	599	Target Neighborhood Hits	478	Shared Neighborhood Hits	247
SwissProt Accessions	Q14678, Q5W0W0, Q8IY65, Q8WX74	Gene names	ANKRD15, KANK, KIAA0172
Domain Architecture
Description	Ankyrin repeat domain-containing protein 15 (Kidney ankyrin repeat- containing protein).

A20A3_HUMAN
NC score	0.340650 (rank : 199)	θ value	0.000786445 (rank : 110)
Query Neighborhood Hits	599	Target Neighborhood Hits	692	Shared Neighborhood Hits	261
SwissProt Accessions	Q5VUR7	Gene names	ANKRD20A3
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A3.

A20A2_HUMAN
NC score	0.340196 (rank : 200)	θ value	0.00102713 (rank : 114)
Query Neighborhood Hits	599	Target Neighborhood Hits	716	Shared Neighborhood Hits	264
SwissProt Accessions	Q4UJ75	Gene names	ANKRD20A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A2.

A20A1_HUMAN
NC score	0.339682 (rank : 201)	θ value	0.000786445 (rank : 109)
Query Neighborhood Hits	599	Target Neighborhood Hits	698	Shared Neighborhood Hits	261
SwissProt Accessions	Q5TYW2, Q9H0H6	Gene names	ANKRD20A1, ANKRD20A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A1.

ANR12_HUMAN
NC score	0.339660 (rank : 202)	θ value	0.21417 (rank : 317)
Query Neighborhood Hits	599	Target Neighborhood Hits	1081	Shared Neighborhood Hits	280
SwissProt Accessions	Q6UB98, O94951, Q658K1, Q6QMF7, Q9H231, Q9H784	Gene names	ANKRD12, ANCO2, KIAA0874
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein).

HECD1_HUMAN
NC score	0.339571 (rank : 203)	θ value	0.00175202 (rank : 134)
Query Neighborhood Hits	599	Target Neighborhood Hits	371	Shared Neighborhood Hits	229
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

A20A4_HUMAN
NC score	0.338684 (rank : 204)	θ value	0.000786445 (rank : 111)
Query Neighborhood Hits	599	Target Neighborhood Hits	710	Shared Neighborhood Hits	263
SwissProt Accessions	Q5SQ80	Gene names	ANKRD20A4
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A4.

HRBL_HUMAN
NC score	0.334334 (rank : 205)	θ value	0.00175202 (rank : 135)
Query Neighborhood Hits	599	Target Neighborhood Hits	179	Shared Neighborhood Hits	54
SwissProt Accessions	O95081, O75429, Q96AB9, Q96GL4	Gene names	HRBL, RABR
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

ANR32_HUMAN
NC score	0.333914 (rank : 206)	θ value	0.813845 (rank : 386)
Query Neighborhood Hits	599	Target Neighborhood Hits	270	Shared Neighborhood Hits	217
SwissProt Accessions	Q9BQI6	Gene names	ANKRD32
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 32.

ANR32_MOUSE
NC score	0.331772 (rank : 207)	θ value	1.06291 (rank : 401)
Query Neighborhood Hits	599	Target Neighborhood Hits	285	Shared Neighborhood Hits	219
SwissProt Accessions	Q8R3P9, Q5XK30, Q8BHY5, Q921Y9	Gene names	Ankrd32
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 32.

OSBL1_HUMAN
NC score	0.330616 (rank : 208)	θ value	0.279714 (rank : 344)
Query Neighborhood Hits	599	Target Neighborhood Hits	368	Shared Neighborhood Hits	246
SwissProt Accessions	Q9BXW6, Q9BZF5, Q9NW87	Gene names	OSBPL1A, ORP1, OSBP8, OSBPL1
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

NFKB2_HUMAN
NC score	0.329559 (rank : 209)	θ value	1.81305 (rank : 438)
Query Neighborhood Hits	599	Target Neighborhood Hits	325	Shared Neighborhood Hits	229
SwissProt Accessions	Q00653, Q04860, Q9BU75, Q9H471, Q9H472	Gene names	NFKB2, LYT10
Domain Architecture
Description	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10) (Oncogene Lyt-10) (Lyt10) [Contains: Nuclear factor NF-kappa-B p52 subunit].

NFKB1_HUMAN
NC score	0.329094 (rank : 210)	θ value	0.163984 (rank : 311)
Query Neighborhood Hits	599	Target Neighborhood Hits	306	Shared Neighborhood Hits	228
SwissProt Accessions	P19838, Q68D84, Q86V43, Q8N4X7, Q9NZC0	Gene names	NFKB1
Domain Architecture
Description	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) [Contains: Nuclear factor NF-kappa-B p50 subunit].

NFKB1_MOUSE
NC score	0.329030 (rank : 211)	θ value	0.163984 (rank : 312)
Query Neighborhood Hits	599	Target Neighborhood Hits	300	Shared Neighborhood Hits	223
SwissProt Accessions	P25799, Q3TZE8, Q3V2V6, Q6TDG8, Q75ZL1, Q80Y21, Q8C712	Gene names	Nfkb1
Domain Architecture
Description	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) (NF-kappa-B1 p84/NF-kappa-B1 p98) [Contains: Nuclear factor NF- kappa-B p50 subunit].

HRBL_MOUSE
NC score	0.327428 (rank : 212)	θ value	0.00102713 (rank : 119)
Query Neighborhood Hits	599	Target Neighborhood Hits	269	Shared Neighborhood Hits	63
SwissProt Accessions	Q80WC7, Q8BKS5, Q99J67	Gene names	Hrbl, Rabr
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

RAI14_HUMAN
NC score	0.327042 (rank : 213)	θ value	0.0431538 (rank : 244)
Query Neighborhood Hits	599	Target Neighborhood Hits	1367	Shared Neighborhood Hits	296
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

RN5A_MOUSE
NC score	0.327032 (rank : 214)	θ value	θ > 10 (rank : 745)
Query Neighborhood Hits	599	Target Neighborhood Hits	899	Shared Neighborhood Hits	242
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

POT22_HUMAN
NC score	0.326387 (rank : 215)	θ value	1.06291 (rank : 410)
Query Neighborhood Hits	599	Target Neighborhood Hits	266	Shared Neighborhood Hits	218
SwissProt Accessions	Q6S545	Gene names	ACTBL1, POTE22
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 22.

CLPB_MOUSE
NC score	0.326363 (rank : 216)	θ value	0.00390308 (rank : 155)
Query Neighborhood Hits	599	Target Neighborhood Hits	289	Shared Neighborhood Hits	207
SwissProt Accessions	Q60649	Gene names	Clpb, Skd3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

NFKB2_MOUSE
NC score	0.326078 (rank : 217)	θ value	1.06291 (rank : 408)
Query Neighborhood Hits	599	Target Neighborhood Hits	326	Shared Neighborhood Hits	226
SwissProt Accessions	Q9WTK5	Gene names	Nfkb2
Domain Architecture
Description	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) [Contains: Nuclear factor NF-kappa-B p52 subunit].

OSBL1_MOUSE
NC score	0.324029 (rank : 218)	θ value	0.62314 (rank : 378)
Query Neighborhood Hits	599	Target Neighborhood Hits	336	Shared Neighborhood Hits	240
SwissProt Accessions	Q91XL9, O88318, Q3TH97, Q673L8, Q6DFU6	Gene names	Osbpl1a, Orp1, Orp1a
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

ANKY2_HUMAN
NC score	0.320799 (rank : 219)	θ value	θ > 10 (rank : 615)
Query Neighborhood Hits	599	Target Neighborhood Hits	306	Shared Neighborhood Hits	217
SwissProt Accessions	Q8IV38, Q96BL3	Gene names	ANKMY2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and MYND domain-containing protein 2.

BCOR_MOUSE
NC score	0.316777 (rank : 220)	θ value	0.62314 (rank : 372)
Query Neighborhood Hits	599	Target Neighborhood Hits	521	Shared Neighborhood Hits	235
SwissProt Accessions	Q8CGN4, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3	Gene names	Bcor, Kiaa1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

ANR47_MOUSE
NC score	0.315505 (rank : 221)	θ value	θ > 10 (rank : 627)
Query Neighborhood Hits	599	Target Neighborhood Hits	350	Shared Neighborhood Hits	229
SwissProt Accessions	Q9Z1P7	Gene names	Ankrd47, D17Ertd288e, Ng28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

RAI14_MOUSE
NC score	0.313032 (rank : 222)	θ value	0.0252991 (rank : 223)
Query Neighborhood Hits	599	Target Neighborhood Hits	1505	Shared Neighborhood Hits	304
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

ANR18_HUMAN
NC score	0.312761 (rank : 223)	θ value	0.0193708 (rank : 210)
Query Neighborhood Hits	599	Target Neighborhood Hits	1106	Shared Neighborhood Hits	284
SwissProt Accessions	Q8IVF6, Q7Z468	Gene names	ANKRD18A, KIAA2015
Domain Architecture
Description	Ankyrin repeat domain-containing protein 18A.

ANR33_HUMAN
NC score	0.311594 (rank : 224)	θ value	θ > 10 (rank : 623)
Query Neighborhood Hits	599	Target Neighborhood Hits	215	Shared Neighborhood Hits	189
SwissProt Accessions	Q7Z3H0, Q5K619, Q5K621, Q5K622, Q5K623, Q5K624, Q6ZUN0	Gene names	ANKRD33, C12orf7
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

ANR33_MOUSE
NC score	0.311402 (rank : 225)	θ value	8.99809 (rank : 563)
Query Neighborhood Hits	599	Target Neighborhood Hits	225	Shared Neighborhood Hits	195
SwissProt Accessions	Q8BXP5, Q8BXP4, Q8R1Z1	Gene names	Ankrd33
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

BCOR_HUMAN
NC score	0.309830 (rank : 226)	θ value	2.36792 (rank : 444)
Query Neighborhood Hits	599	Target Neighborhood Hits	609	Shared Neighborhood Hits	244
SwissProt Accessions	Q6W2J9, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2	Gene names	BCOR, KIAA1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

ASB6_HUMAN
NC score	0.307763 (rank : 227)	θ value	θ > 10 (rank : 638)
Query Neighborhood Hits	599	Target Neighborhood Hits	256	Shared Neighborhood Hits	205
SwissProt Accessions	Q9NWX5	Gene names	ASB6
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 6 (ASB-6).

ANKY2_MOUSE
NC score	0.305127 (rank : 228)	θ value	θ > 10 (rank : 616)
Query Neighborhood Hits	599	Target Neighborhood Hits	316	Shared Neighborhood Hits	216
SwissProt Accessions	Q3TPE9, Q8BK14, Q8BYW5, Q8R3N4, Q921J1	Gene names	Ankmy2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and MYND domain-containing protein 2.

ANR47_HUMAN
NC score	0.303821 (rank : 229)	θ value	θ > 10 (rank : 626)
Query Neighborhood Hits	599	Target Neighborhood Hits	369	Shared Neighborhood Hits	229
SwissProt Accessions	Q6NY19, Q6NZI1, Q6ZQR3, Q8IUV2	Gene names	ANKRD47
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

ASB6_MOUSE
NC score	0.301852 (rank : 230)	θ value	θ > 10 (rank : 639)
Query Neighborhood Hits	599	Target Neighborhood Hits	264	Shared Neighborhood Hits	207
SwissProt Accessions	Q91ZU1, Q8VEC6	Gene names	Asb6
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 6 (ASB-6).

CLPB_HUMAN
NC score	0.296800 (rank : 231)	θ value	0.00228821 (rank : 141)
Query Neighborhood Hits	599	Target Neighborhood Hits	265	Shared Neighborhood Hits	196
SwissProt Accessions	Q9H078, Q8ND11, Q9H8Y0	Gene names	CLPB, SKD3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

CD2A1_MOUSE
NC score	0.295701 (rank : 232)	θ value	θ > 10 (rank : 646)
Query Neighborhood Hits	599	Target Neighborhood Hits	206	Shared Neighborhood Hits	177
SwissProt Accessions	P51480, O89088, P97510, P97937, Q6PEA2, Q78E39, Q78E57, Q792X7, Q9QWH6, Q9QWH7, Q9QWH8	Gene names	Cdkn2a, P16ink4a
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 2A, isoforms 1/2 (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4) (p16-INK4a).

MPP8_HUMAN
NC score	0.293595 (rank : 233)	θ value	θ > 10 (rank : 694)
Query Neighborhood Hits	599	Target Neighborhood Hits	948	Shared Neighborhood Hits	257
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

SH3K1_HUMAN
NC score	0.292761 (rank : 234)	θ value	4.1701e-05 (rank : 53)
Query Neighborhood Hits	599	Target Neighborhood Hits	341	Shared Neighborhood Hits	170
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
NC score	0.290193 (rank : 235)	θ value	5.44631e-05 (rank : 59)
Query Neighborhood Hits	599	Target Neighborhood Hits	332	Shared Neighborhood Hits	169
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

ANR25_HUMAN
NC score	0.288954 (rank : 236)	θ value	θ > 10 (rank : 621)
Query Neighborhood Hits	599	Target Neighborhood Hits	350	Shared Neighborhood Hits	222
SwissProt Accessions	Q63ZY3, Q3KQZ3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210	Gene names	ANKRD25, KIAA1518, SIP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25 (SRC-1-interacting protein) (SRC1-interacting protein).

CD2AP_HUMAN
NC score	0.287769 (rank : 237)	θ value	0.000270298 (rank : 89)
Query Neighborhood Hits	599	Target Neighborhood Hits	315	Shared Neighborhood Hits	171
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
NC score	0.284981 (rank : 238)	θ value	0.00134147 (rank : 129)
Query Neighborhood Hits	599	Target Neighborhood Hits	336	Shared Neighborhood Hits	186
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

NUD12_MOUSE
NC score	0.284874 (rank : 239)	θ value	0.47712 (rank : 366)
Query Neighborhood Hits	599	Target Neighborhood Hits	243	Shared Neighborhood Hits	193
SwissProt Accessions	Q9DCN1, Q6PFA5	Gene names	Nudt12
Domain Architecture	No domain graphic available
Description	Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12).

ANR25_MOUSE
NC score	0.278867 (rank : 240)	θ value	θ > 10 (rank : 622)
Query Neighborhood Hits	599	Target Neighborhood Hits	398	Shared Neighborhood Hits	235
SwissProt Accessions	Q8BX02, Q8BLD5, Q91Z35	Gene names	Ankrd25
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25.

AN30A_HUMAN
NC score	0.277588 (rank : 241)	θ value	0.0736092 (rank : 262)
Query Neighborhood Hits	599	Target Neighborhood Hits	1119	Shared Neighborhood Hits	280
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

DP13A_HUMAN
NC score	0.277271 (rank : 242)	θ value	5.62301e-10 (rank : 35)
Query Neighborhood Hits	599	Target Neighborhood Hits	107	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

KRIT1_MOUSE
NC score	0.277083 (rank : 243)	θ value	θ > 10 (rank : 689)
Query Neighborhood Hits	599	Target Neighborhood Hits	258	Shared Neighborhood Hits	200
SwissProt Accessions	Q6S5J6, Q6VSV2, Q7TPR8, Q8C9Q6, Q9EPY2, Q9ERH0	Gene names	Krit1, Ccm1
Domain Architecture	No domain graphic available
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog).

NCF2_HUMAN
NC score	0.276687 (rank : 244)	θ value	0.00102713 (rank : 122)
Query Neighborhood Hits	599	Target Neighborhood Hits	229	Shared Neighborhood Hits	141
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

DP13A_MOUSE
NC score	0.274481 (rank : 245)	θ value	3.64472e-09 (rank : 36)
Query Neighborhood Hits	599	Target Neighborhood Hits	96	Shared Neighborhood Hits	20
SwissProt Accessions	Q8K3H0, Q3UJP7, Q69ZJ9, Q8BWZ8, Q8VCJ8, Q9CUW4	Gene names	Appl1, Dip13a, Kiaa1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

ANR38_HUMAN
NC score	0.273742 (rank : 246)	θ value	3.0926 (rank : 464)
Query Neighborhood Hits	599	Target Neighborhood Hits	443	Shared Neighborhood Hits	224
SwissProt Accessions	Q5T7N3, Q6P9A0, Q86T71, Q86VE6, Q8NAX3	Gene names	ANKRD38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

KRIT1_HUMAN
NC score	0.271193 (rank : 247)	θ value	θ > 10 (rank : 688)
Query Neighborhood Hits	599	Target Neighborhood Hits	258	Shared Neighborhood Hits	193
SwissProt Accessions	O00522, O43894, Q506L6, Q6U276, Q75N19, Q9H180, Q9H264, Q9HAX5	Gene names	KRIT1, CCM1
Domain Architecture
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein).

SH3G1_MOUSE
NC score	0.271112 (rank : 248)	θ value	1.09739e-05 (rank : 49)
Query Neighborhood Hits	599	Target Neighborhood Hits	291	Shared Neighborhood Hits	159
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G1_HUMAN
NC score	0.270971 (rank : 249)	θ value	8.40245e-06 (rank : 47)
Query Neighborhood Hits	599	Target Neighborhood Hits	307	Shared Neighborhood Hits	158
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

NUD12_HUMAN
NC score	0.270823 (rank : 250)	θ value	0.0736092 (rank : 270)
Query Neighborhood Hits	599	Target Neighborhood Hits	222	Shared Neighborhood Hits	173
SwissProt Accessions	Q9BQG2, Q8TAL7	Gene names	NUDT12
Domain Architecture	No domain graphic available
Description	Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12).

SH3G3_MOUSE
NC score	0.270540 (rank : 251)	θ value	0.000121331 (rank : 71)
Query Neighborhood Hits	599	Target Neighborhood Hits	236	Shared Neighborhood Hits	149
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

AN13C_HUMAN
NC score	0.270100 (rank : 252)	θ value	0.0736092 (rank : 260)
Query Neighborhood Hits	599	Target Neighborhood Hits	241	Shared Neighborhood Hits	205
SwissProt Accessions	Q8N6S4, Q5VYH4, Q5VYH5, Q6PJE4, Q9H0N9	Gene names	ANKRD13C
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13C.

ILK2_HUMAN
NC score	0.269282 (rank : 253)	θ value	0.00102713 (rank : 121)
Query Neighborhood Hits	599	Target Neighborhood Hits	848	Shared Neighborhood Hits	244
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

SH3G2_MOUSE
NC score	0.268206 (rank : 254)	θ value	0.000158464 (rank : 80)
Query Neighborhood Hits	599	Target Neighborhood Hits	319	Shared Neighborhood Hits	159
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

DP13B_MOUSE
NC score	0.267412 (rank : 255)	θ value	9.92553e-07 (rank : 41)
Query Neighborhood Hits	599	Target Neighborhood Hits	58	Shared Neighborhood Hits	26
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

SH3G3_HUMAN
NC score	0.267130 (rank : 256)	θ value	0.000270298 (rank : 91)
Query Neighborhood Hits	599	Target Neighborhood Hits	222	Shared Neighborhood Hits	145
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

ANR43_HUMAN
NC score	0.265400 (rank : 257)	θ value	θ > 10 (rank : 624)
Query Neighborhood Hits	599	Target Neighborhood Hits	209	Shared Neighborhood Hits	176
SwissProt Accessions	Q2M3V2, Q8NAE7	Gene names	ANKRD43
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 43.

CD2A1_HUMAN
NC score	0.265384 (rank : 258)	θ value	θ > 10 (rank : 645)
Query Neighborhood Hits	599	Target Neighborhood Hits	196	Shared Neighborhood Hits	169
SwissProt Accessions	P42771, O95440, Q15191, Q5VVJ5, Q96B52, Q9NP05	Gene names	CDKN2A, CDKN2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4) (p16-INK4a) (p16INK4A) (Multiple tumor suppressor 1) (MTS1).

CDN2B_MOUSE
NC score	0.265039 (rank : 259)	θ value	θ > 10 (rank : 648)
Query Neighborhood Hits	599	Target Neighborhood Hits	201	Shared Neighborhood Hits	174
SwissProt Accessions	P55271	Gene names	Cdkn2b
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b).

AN13C_MOUSE
NC score	0.264911 (rank : 260)	θ value	0.0736092 (rank : 261)
Query Neighborhood Hits	599	Target Neighborhood Hits	242	Shared Neighborhood Hits	201
SwissProt Accessions	Q3UX43, Q6P1G4	Gene names	Ankrd13c
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13C.

ANR40_HUMAN
NC score	0.263608 (rank : 261)	θ value	0.62314 (rank : 369)
Query Neighborhood Hits	599	Target Neighborhood Hits	224	Shared Neighborhood Hits	187
SwissProt Accessions	Q6AI12, Q96E32	Gene names	ANKRD40
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 40.

ANR43_MOUSE
NC score	0.262863 (rank : 262)	θ value	θ > 10 (rank : 625)
Query Neighborhood Hits	599	Target Neighborhood Hits	214	Shared Neighborhood Hits	181
SwissProt Accessions	Q8BLS7	Gene names	Ankrd43
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 43.

SH3G2_HUMAN
NC score	0.262520 (rank : 263)	θ value	0.00102713 (rank : 124)
Query Neighborhood Hits	599	Target Neighborhood Hits	324	Shared Neighborhood Hits	157
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

ANR38_MOUSE
NC score	0.262296 (rank : 264)	θ value	1.81305 (rank : 429)
Query Neighborhood Hits	599	Target Neighborhood Hits	512	Shared Neighborhood Hits	228
SwissProt Accessions	Q6P9J5, Q8BV03	Gene names	Ankrd38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

ANR40_MOUSE
NC score	0.260494 (rank : 265)	θ value	0.813845 (rank : 387)
Query Neighborhood Hits	599	Target Neighborhood Hits	228	Shared Neighborhood Hits	190
SwissProt Accessions	Q5SUE8, Q8R595, Q9CU71	Gene names	Ankrd40
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 40.

ILK1_HUMAN
NC score	0.260050 (rank : 266)	θ value	0.00102713 (rank : 120)
Query Neighborhood Hits	599	Target Neighborhood Hits	857	Shared Neighborhood Hits	244
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

CDN2B_HUMAN
NC score	0.257706 (rank : 267)	θ value	θ > 10 (rank : 647)
Query Neighborhood Hits	599	Target Neighborhood Hits	196	Shared Neighborhood Hits	171
SwissProt Accessions	P42772, Q6FI09	Gene names	CDKN2B, MTS2
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b) (p15INK4B) (Multiple tumor suppressor 2) (MTS2).

ILK_MOUSE
NC score	0.257327 (rank : 268)	θ value	0.00228821 (rank : 143)
Query Neighborhood Hits	599	Target Neighborhood Hits	858	Shared Neighborhood Hits	246
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

RHG26_HUMAN
NC score	0.255855 (rank : 269)	θ value	0.21417 (rank : 329)
Query Neighborhood Hits	599	Target Neighborhood Hits	281	Shared Neighborhood Hits	132
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

ANKK1_HUMAN
NC score	0.254782 (rank : 270)	θ value	0.0563607 (rank : 247)
Query Neighborhood Hits	599	Target Neighborhood Hits	1075	Shared Neighborhood Hits	249
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

UACA_HUMAN
NC score	0.253865 (rank : 271)	θ value	1.38821 (rank : 427)
Query Neighborhood Hits	599	Target Neighborhood Hits	1622	Shared Neighborhood Hits	306
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

STAM2_MOUSE
NC score	0.253769 (rank : 272)	θ value	1.09739e-05 (rank : 50)
Query Neighborhood Hits	599	Target Neighborhood Hits	285	Shared Neighborhood Hits	154
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

VINEX_HUMAN
NC score	0.252757 (rank : 273)	θ value	0.00298849 (rank : 152)
Query Neighborhood Hits	599	Target Neighborhood Hits	270	Shared Neighborhood Hits	160
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

AN13B_MOUSE
NC score	0.252472 (rank : 274)	θ value	θ > 10 (rank : 612)
Query Neighborhood Hits	599	Target Neighborhood Hits	276	Shared Neighborhood Hits	220
SwissProt Accessions	Q5F259, Q6IR40	Gene names	Ankrd13b
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13B.

AN13B_HUMAN
NC score	0.251675 (rank : 275)	θ value	θ > 10 (rank : 611)
Query Neighborhood Hits	599	Target Neighborhood Hits	265	Shared Neighborhood Hits	218
SwissProt Accessions	Q86YJ7, Q8N7S9	Gene names	ANKRD13B
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13B.

STAM1_MOUSE
NC score	0.251554 (rank : 276)	θ value	0.00869519 (rank : 187)
Query Neighborhood Hits	599	Target Neighborhood Hits	273	Shared Neighborhood Hits	154
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

RIPK4_HUMAN
NC score	0.251240 (rank : 277)	θ value	0.0193708 (rank : 213)
Query Neighborhood Hits	599	Target Neighborhood Hits	1094	Shared Neighborhood Hits	249
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

ANKK1_MOUSE
NC score	0.250275 (rank : 278)	θ value	0.0330416 (rank : 226)
Query Neighborhood Hits	599	Target Neighborhood Hits	1072	Shared Neighborhood Hits	249
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

NCF4_HUMAN
NC score	0.250217 (rank : 279)	θ value	0.00665767 (rank : 174)
Query Neighborhood Hits	599	Target Neighborhood Hits	161	Shared Neighborhood Hits	114
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

VINEX_MOUSE
NC score	0.250098 (rank : 280)	θ value	0.00665767 (rank : 179)
Query Neighborhood Hits	599	Target Neighborhood Hits	286	Shared Neighborhood Hits	165
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

DP13B_HUMAN
NC score	0.249308 (rank : 281)	θ value	0.00102713 (rank : 118)
Query Neighborhood Hits	599	Target Neighborhood Hits	58	Shared Neighborhood Hits	22
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

ABI2_HUMAN
NC score	0.248121 (rank : 282)	θ value	0.0113563 (rank : 190)
Query Neighborhood Hits	599	Target Neighborhood Hits	350	Shared Neighborhood Hits	176
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

UACA_MOUSE
NC score	0.245262 (rank : 283)	θ value	0.279714 (rank : 346)
Query Neighborhood Hits	599	Target Neighborhood Hits	1620	Shared Neighborhood Hits	302
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

STAM1_HUMAN
NC score	0.244630 (rank : 284)	θ value	0.00869519 (rank : 186)
Query Neighborhood Hits	599	Target Neighborhood Hits	271	Shared Neighborhood Hits	155
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

NCF4_MOUSE
NC score	0.243910 (rank : 285)	θ value	0.0330416 (rank : 234)
Query Neighborhood Hits	599	Target Neighborhood Hits	177	Shared Neighborhood Hits	123
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

ANR26_MOUSE
NC score	0.242780 (rank : 286)	θ value	0.0148317 (rank : 201)
Query Neighborhood Hits	599	Target Neighborhood Hits	1554	Shared Neighborhood Hits	303
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

STAM2_HUMAN
NC score	0.242611 (rank : 287)	θ value	0.00134147 (rank : 133)
Query Neighborhood Hits	599	Target Neighborhood Hits	288	Shared Neighborhood Hits	158
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

SRBS1_MOUSE
NC score	0.239304 (rank : 288)	θ value	0.21417 (rank : 335)
Query Neighborhood Hits	599	Target Neighborhood Hits	409	Shared Neighborhood Hits	177
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

PACN1_HUMAN
NC score	0.238826 (rank : 289)	θ value	0.000602161 (rank : 106)
Query Neighborhood Hits	599	Target Neighborhood Hits	320	Shared Neighborhood Hits	154
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
NC score	0.238693 (rank : 290)	θ value	0.000602161 (rank : 107)
Query Neighborhood Hits	599	Target Neighborhood Hits	283	Shared Neighborhood Hits	152
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

ABI2_MOUSE
NC score	0.238441 (rank : 291)	θ value	0.0113563 (rank : 191)
Query Neighborhood Hits	599	Target Neighborhood Hits	266	Shared Neighborhood Hits	149
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

PACN2_HUMAN
NC score	0.237399 (rank : 292)	θ value	0.000602161 (rank : 108)
Query Neighborhood Hits	599	Target Neighborhood Hits	339	Shared Neighborhood Hits	163
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

ARHG7_MOUSE
NC score	0.237349 (rank : 293)	θ value	0.000461057 (rank : 101)
Query Neighborhood Hits	599	Target Neighborhood Hits	396	Shared Neighborhood Hits	176
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG7_HUMAN
NC score	0.236707 (rank : 294)	θ value	0.000158464 (rank : 75)
Query Neighborhood Hits	599	Target Neighborhood Hits	347	Shared Neighborhood Hits	171
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

PACN2_MOUSE
NC score	0.235475 (rank : 295)	θ value	0.00102713 (rank : 123)
Query Neighborhood Hits	599	Target Neighborhood Hits	382	Shared Neighborhood Hits	165
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

SRBS1_HUMAN
NC score	0.235263 (rank : 296)	θ value	0.21417 (rank : 334)
Query Neighborhood Hits	599	Target Neighborhood Hits	396	Shared Neighborhood Hits	173
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

HCLS1_HUMAN
NC score	0.234213 (rank : 297)	θ value	0.21417 (rank : 323)
Query Neighborhood Hits	599	Target Neighborhood Hits	358	Shared Neighborhood Hits	161
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

ARHG6_MOUSE
NC score	0.232167 (rank : 298)	θ value	0.00102713 (rank : 116)
Query Neighborhood Hits	599	Target Neighborhood Hits	394	Shared Neighborhood Hits	169
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ABTB2_HUMAN
NC score	0.231413 (rank : 299)	θ value	θ > 10 (rank : 607)
Query Neighborhood Hits	599	Target Neighborhood Hits	391	Shared Neighborhood Hits	205
SwissProt Accessions	Q8N961, Q6MZW4, Q8NB44	Gene names	ABTB2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

HCLS1_MOUSE
NC score	0.230983 (rank : 300)	θ value	0.365318 (rank : 353)
Query Neighborhood Hits	599	Target Neighborhood Hits	329	Shared Neighborhood Hits	159
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

ABI1_MOUSE
NC score	0.228600 (rank : 301)	θ value	0.21417 (rank : 316)
Query Neighborhood Hits	599	Target Neighborhood Hits	246	Shared Neighborhood Hits	150
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ARHG6_HUMAN
NC score	0.227706 (rank : 302)	θ value	0.00102713 (rank : 115)
Query Neighborhood Hits	599	Target Neighborhood Hits	376	Shared Neighborhood Hits	165
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ABI1_HUMAN
NC score	0.226895 (rank : 303)	θ value	0.21417 (rank : 315)
Query Neighborhood Hits	599	Target Neighborhood Hits	257	Shared Neighborhood Hits	157
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ANR26_HUMAN
NC score	0.226563 (rank : 304)	θ value	0.813845 (rank : 385)
Query Neighborhood Hits	599	Target Neighborhood Hits	1614	Shared Neighborhood Hits	299
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

DNMBP_HUMAN
NC score	0.225792 (rank : 305)	θ value	0.00390308 (rank : 156)
Query Neighborhood Hits	599	Target Neighborhood Hits	413	Shared Neighborhood Hits	175
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

PACN3_MOUSE
NC score	0.225417 (rank : 306)	θ value	0.00665767 (rank : 176)
Query Neighborhood Hits	599	Target Neighborhood Hits	380	Shared Neighborhood Hits	160
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

DNMBP_MOUSE
NC score	0.225185 (rank : 307)	θ value	0.00390308 (rank : 157)
Query Neighborhood Hits	599	Target Neighborhood Hits	435	Shared Neighborhood Hits	178
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

SRC8_HUMAN
NC score	0.224699 (rank : 308)	θ value	0.62314 (rank : 381)
Query Neighborhood Hits	599	Target Neighborhood Hits	269	Shared Neighborhood Hits	146
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

NOTC4_MOUSE
NC score	0.223139 (rank : 309)	θ value	0.00390308 (rank : 160)
Query Neighborhood Hits	599	Target Neighborhood Hits	872	Shared Neighborhood Hits	234
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

PACN3_HUMAN
NC score	0.222863 (rank : 310)	θ value	0.00665767 (rank : 175)
Query Neighborhood Hits	599	Target Neighborhood Hits	385	Shared Neighborhood Hits	151
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

ABTB2_MOUSE
NC score	0.222158 (rank : 311)	θ value	θ > 10 (rank : 608)
Query Neighborhood Hits	599	Target Neighborhood Hits	414	Shared Neighborhood Hits	203
SwissProt Accessions	Q7TQI7	Gene names	Abtb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

PPIP1_HUMAN
NC score	0.221942 (rank : 312)	θ value	0.0113563 (rank : 198)
Query Neighborhood Hits	599	Target Neighborhood Hits	389	Shared Neighborhood Hits	169
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
NC score	0.220980 (rank : 313)	θ value	0.0563607 (rank : 256)
Query Neighborhood Hits	599	Target Neighborhood Hits	377	Shared Neighborhood Hits	173
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

SRC8_MOUSE
NC score	0.220817 (rank : 314)	θ value	0.62314 (rank : 382)
Query Neighborhood Hits	599	Target Neighborhood Hits	292	Shared Neighborhood Hits	145
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

STAC_HUMAN
NC score	0.218866 (rank : 315)	θ value	0.0961366 (rank : 282)
Query Neighborhood Hits	599	Target Neighborhood Hits	276	Shared Neighborhood Hits	146
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

NOTC4_HUMAN
NC score	0.218650 (rank : 316)	θ value	0.00175202 (rank : 136)
Query Neighborhood Hits	599	Target Neighborhood Hits	905	Shared Neighborhood Hits	236
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

OPHN1_MOUSE
NC score	0.215995 (rank : 317)	θ value	2.88788e-06 (rank : 43)
Query Neighborhood Hits	599	Target Neighborhood Hits	174	Shared Neighborhood Hits	34
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

LASP1_HUMAN
NC score	0.213110 (rank : 318)	θ value	0.00390308 (rank : 158)
Query Neighborhood Hits	599	Target Neighborhood Hits	293	Shared Neighborhood Hits	131
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
NC score	0.212963 (rank : 319)	θ value	0.00390308 (rank : 159)
Query Neighborhood Hits	599	Target Neighborhood Hits	297	Shared Neighborhood Hits	132
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

TNI3K_HUMAN
NC score	0.212561 (rank : 320)	θ value	0.00298849 (rank : 151)
Query Neighborhood Hits	599	Target Neighborhood Hits	1084	Shared Neighborhood Hits	249
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

ANKY1_HUMAN
NC score	0.210620 (rank : 321)	θ value	θ > 10 (rank : 614)
Query Neighborhood Hits	599	Target Neighborhood Hits	248	Shared Neighborhood Hits	176
SwissProt Accessions	Q9P2S6, Q8IYX5, Q8NDK5, Q9NX10	Gene names	ANKMY1, TSAL1, ZMYND13
Domain Architecture
Description	Ankyrin repeat and MYND domain-containing protein 1 (Testis-specific ankyrin-like protein 1) (Zinc-finger MYND domain-containing protein 13).

TRPV6_MOUSE
NC score	0.210577 (rank : 322)	θ value	θ > 10 (rank : 785)
Query Neighborhood Hits	599	Target Neighborhood Hits	284	Shared Neighborhood Hits	204
SwissProt Accessions	Q91WD2	Gene names	Trpv6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1).

STAC_MOUSE
NC score	0.210505 (rank : 323)	θ value	0.125558 (rank : 300)
Query Neighborhood Hits	599	Target Neighborhood Hits	268	Shared Neighborhood Hits	140
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

TNI3K_MOUSE
NC score	0.208931 (rank : 324)	θ value	0.00102713 (rank : 126)
Query Neighborhood Hits	599	Target Neighborhood Hits	1079	Shared Neighborhood Hits	250
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

GLSL_HUMAN
NC score	0.208193 (rank : 325)	θ value	θ > 10 (rank : 679)
Query Neighborhood Hits	599	Target Neighborhood Hits	211	Shared Neighborhood Hits	172
SwissProt Accessions	Q9UI32, Q9NYY2, Q9UI31	Gene names	GLS2, GA
Domain Architecture
Description	Glutaminase liver isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (L-glutaminase).

GRAP2_MOUSE
NC score	0.208106 (rank : 326)	θ value	0.0431538 (rank : 241)
Query Neighborhood Hits	599	Target Neighborhood Hits	297	Shared Neighborhood Hits	152
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP2_HUMAN
NC score	0.206214 (rank : 327)	θ value	0.0330416 (rank : 232)
Query Neighborhood Hits	599	Target Neighborhood Hits	304	Shared Neighborhood Hits	153
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

DBNL_MOUSE
NC score	0.204828 (rank : 328)	θ value	0.163984 (rank : 307)
Query Neighborhood Hits	599	Target Neighborhood Hits	306	Shared Neighborhood Hits	137
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

CRKL_HUMAN
NC score	0.203377 (rank : 329)	θ value	0.0431538 (rank : 238)
Query Neighborhood Hits	599	Target Neighborhood Hits	313	Shared Neighborhood Hits	149
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

DBNL_HUMAN
NC score	0.201977 (rank : 330)	θ value	0.21417 (rank : 320)
Query Neighborhood Hits	599	Target Neighborhood Hits	244	Shared Neighborhood Hits	129
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

ITSN1_MOUSE
NC score	0.201433 (rank : 331)	θ value	7.59969e-07 (rank : 39)
Query Neighborhood Hits	599	Target Neighborhood Hits	1669	Shared Neighborhood Hits	274
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

GLSL_MOUSE
NC score	0.201357 (rank : 332)	θ value	θ > 10 (rank : 680)
Query Neighborhood Hits	599	Target Neighborhood Hits	212	Shared Neighborhood Hits	170
SwissProt Accessions	Q571F8	Gene names	Gls2, Kiaa4146
Domain Architecture	No domain graphic available
Description	Glutaminase liver isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (L-glutaminase).

ITSN2_HUMAN
NC score	0.201199 (rank : 333)	θ value	1.09739e-05 (rank : 48)
Query Neighborhood Hits	599	Target Neighborhood Hits	1173	Shared Neighborhood Hits	231
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ASB14_HUMAN
NC score	0.200848 (rank : 334)	θ value	θ > 10 (rank : 637)
Query Neighborhood Hits	599	Target Neighborhood Hits	187	Shared Neighborhood Hits	155
SwissProt Accessions	Q8WXK2	Gene names	ASB14
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 14 (ASB-14).

NOTC3_MOUSE
NC score	0.200473 (rank : 335)	θ value	0.000786445 (rank : 113)
Query Neighborhood Hits	599	Target Neighborhood Hits	975	Shared Neighborhood Hits	261
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

CRKL_MOUSE
NC score	0.200020 (rank : 336)	θ value	0.0736092 (rank : 265)
Query Neighborhood Hits	599	Target Neighborhood Hits	307	Shared Neighborhood Hits	146
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

SNX18_MOUSE
NC score	0.199929 (rank : 337)	θ value	0.00102713 (rank : 125)
Query Neighborhood Hits	599	Target Neighborhood Hits	198	Shared Neighborhood Hits	114
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

GRB2_HUMAN
NC score	0.199764 (rank : 338)	θ value	0.21417 (rank : 321)
Query Neighborhood Hits	599	Target Neighborhood Hits	310	Shared Neighborhood Hits	155
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

AN13A_HUMAN
NC score	0.199572 (rank : 339)	θ value	θ > 10 (rank : 609)
Query Neighborhood Hits	599	Target Neighborhood Hits	243	Shared Neighborhood Hits	191
SwissProt Accessions	Q8IZ07, O60736	Gene names	ANKRD13A, ANKRD13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13A (Protein KE03).

GRB2_MOUSE
NC score	0.199097 (rank : 340)	θ value	0.21417 (rank : 322)
Query Neighborhood Hits	599	Target Neighborhood Hits	312	Shared Neighborhood Hits	155
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

CRK_MOUSE
NC score	0.199097 (rank : 341)	θ value	0.0148317 (rank : 205)
Query Neighborhood Hits	599	Target Neighborhood Hits	314	Shared Neighborhood Hits	146
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

STAC3_MOUSE
NC score	0.199045 (rank : 342)	θ value	0.125558 (rank : 299)
Query Neighborhood Hits	599	Target Neighborhood Hits	232	Shared Neighborhood Hits	121
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_HUMAN
NC score	0.198803 (rank : 343)	θ value	0.125558 (rank : 298)
Query Neighborhood Hits	599	Target Neighborhood Hits	228	Shared Neighborhood Hits	121
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

NOTC3_HUMAN
NC score	0.198246 (rank : 344)	θ value	0.00228821 (rank : 144)
Query Neighborhood Hits	599	Target Neighborhood Hits	1062	Shared Neighborhood Hits	254
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

GRAP_MOUSE
NC score	0.197445 (rank : 345)	θ value	0.00509761 (rank : 168)
Query Neighborhood Hits	599	Target Neighborhood Hits	309	Shared Neighborhood Hits	158
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

CRK_HUMAN
NC score	0.196672 (rank : 346)	θ value	0.0148317 (rank : 204)
Query Neighborhood Hits	599	Target Neighborhood Hits	308	Shared Neighborhood Hits	148
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SNX18_HUMAN
NC score	0.196063 (rank : 347)	θ value	0.00175202 (rank : 138)
Query Neighborhood Hits	599	Target Neighborhood Hits	207	Shared Neighborhood Hits	112
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

OPHN1_HUMAN
NC score	0.194994 (rank : 348)	θ value	6.43352e-06 (rank : 45)
Query Neighborhood Hits	599	Target Neighborhood Hits	161	Shared Neighborhood Hits	34
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

ANKR9_MOUSE
NC score	0.194930 (rank : 349)	θ value	0.0961366 (rank : 274)
Query Neighborhood Hits	599	Target Neighborhood Hits	120	Shared Neighborhood Hits	110
SwissProt Accessions	Q8BH83, Q3TA09, Q8BHR3	Gene names	Ankrd9
Domain Architecture
Description	Ankyrin repeat domain-containing protein 9.

ITSN1_HUMAN
NC score	0.194128 (rank : 350)	θ value	8.40245e-06 (rank : 46)
Query Neighborhood Hits	599	Target Neighborhood Hits	1757	Shared Neighborhood Hits	268
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN2_MOUSE
NC score	0.193909 (rank : 351)	θ value	2.44474e-05 (rank : 51)
Query Neighborhood Hits	599	Target Neighborhood Hits	1371	Shared Neighborhood Hits	234
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

NOTC2_HUMAN
NC score	0.193409 (rank : 352)	θ value	0.0563607 (rank : 254)
Query Neighborhood Hits	599	Target Neighborhood Hits	1113	Shared Neighborhood Hits	260
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

DGKI_HUMAN
NC score	0.193382 (rank : 353)	θ value	0.125558 (rank : 292)
Query Neighborhood Hits	599	Target Neighborhood Hits	609	Shared Neighborhood Hits	191
SwissProt Accessions	O75912, Q9NZ49	Gene names	DGKI
Domain Architecture
Description	Diacylglycerol kinase iota (EC 2.7.1.107) (Diglyceride kinase iota) (DGK-iota) (DAG kinase iota).

GRAP_HUMAN
NC score	0.193188 (rank : 354)	θ value	0.0252991 (rank : 220)
Query Neighborhood Hits	599	Target Neighborhood Hits	307	Shared Neighborhood Hits	159
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

CT012_MOUSE
NC score	0.191532 (rank : 355)	θ value	θ > 10 (rank : 663)
Query Neighborhood Hits	599	Target Neighborhood Hits	229	Shared Neighborhood Hits	156
SwissProt Accessions	Q8C008, Q8C060	Gene names
Domain Architecture	No domain graphic available
Description	Protein C20orf12 homolog.

TRPV5_MOUSE
NC score	0.190981 (rank : 356)	θ value	θ > 10 (rank : 783)
Query Neighborhood Hits	599	Target Neighborhood Hits	278	Shared Neighborhood Hits	203
SwissProt Accessions	P69744	Gene names	Trpv5
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC1) (Calcium transport protein 2) (CaT2).

NOTC2_MOUSE
NC score	0.190398 (rank : 357)	θ value	0.0563607 (rank : 255)
Query Neighborhood Hits	599	Target Neighborhood Hits	1069	Shared Neighborhood Hits	249
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

AN13A_MOUSE
NC score	0.190387 (rank : 358)	θ value	θ > 10 (rank : 610)
Query Neighborhood Hits	599	Target Neighborhood Hits	226	Shared Neighborhood Hits	187
SwissProt Accessions	Q80UP5, Q2VPQ7, Q6P7F2	Gene names	Ankrd13a, Ankrd13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13A.

NOTC1_HUMAN
NC score	0.188273 (rank : 359)	θ value	0.163984 (rank : 313)
Query Neighborhood Hits	599	Target Neighborhood Hits	906	Shared Neighborhood Hits	239
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

NCK1_HUMAN
NC score	0.188114 (rank : 360)	θ value	0.163984 (rank : 310)
Query Neighborhood Hits	599	Target Neighborhood Hits	312	Shared Neighborhood Hits	151
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NEBL_HUMAN
NC score	0.187937 (rank : 361)	θ value	0.0431538 (rank : 242)
Query Neighborhood Hits	599	Target Neighborhood Hits	457	Shared Neighborhood Hits	159
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

GLSK_HUMAN
NC score	0.186755 (rank : 362)	θ value	θ > 10 (rank : 678)
Query Neighborhood Hits	599	Target Neighborhood Hits	204	Shared Neighborhood Hits	166
SwissProt Accessions	O94925, Q9UL05, Q9UL06, Q9UL07, Q9UN40	Gene names	GLS, GLS1, KIAA0838
Domain Architecture
Description	Glutaminase kidney isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (K-glutaminase).

DAPK1_MOUSE
NC score	0.186703 (rank : 363)	θ value	0.000121331 (rank : 67)
Query Neighborhood Hits	599	Target Neighborhood Hits	1138	Shared Neighborhood Hits	250
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

BCAR1_HUMAN
NC score	0.185634 (rank : 364)	θ value	0.00509761 (rank : 167)
Query Neighborhood Hits	599	Target Neighborhood Hits	554	Shared Neighborhood Hits	175
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

ABI3_HUMAN
NC score	0.185228 (rank : 365)	θ value	θ > 10 (rank : 602)
Query Neighborhood Hits	599	Target Neighborhood Hits	227	Shared Neighborhood Hits	134
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

BCAR1_MOUSE
NC score	0.183006 (rank : 366)	θ value	0.00869519 (rank : 182)
Query Neighborhood Hits	599	Target Neighborhood Hits	438	Shared Neighborhood Hits	168
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

DGKZ_HUMAN
NC score	0.182412 (rank : 367)	θ value	1.38821 (rank : 418)
Query Neighborhood Hits	599	Target Neighborhood Hits	551	Shared Neighborhood Hits	194
SwissProt Accessions	Q13574, O00542	Gene names	DGKZ, DAGK6
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

AHI1_HUMAN
NC score	0.181434 (rank : 368)	θ value	0.00020696 (rank : 81)
Query Neighborhood Hits	599	Target Neighborhood Hits	537	Shared Neighborhood Hits	157
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
NC score	0.180841 (rank : 369)	θ value	0.000121331 (rank : 66)
Query Neighborhood Hits	599	Target Neighborhood Hits	496	Shared Neighborhood Hits	157
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

DAPK1_HUMAN
NC score	0.179575 (rank : 370)	θ value	0.000158464 (rank : 76)
Query Neighborhood Hits	599	Target Neighborhood Hits	1130	Shared Neighborhood Hits	248
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

TEX14_MOUSE
NC score	0.178723 (rank : 371)	θ value	θ > 10 (rank : 774)
Query Neighborhood Hits	599	Target Neighborhood Hits	1333	Shared Neighborhood Hits	270
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_HUMAN
NC score	0.177880 (rank : 372)	θ value	θ > 10 (rank : 773)
Query Neighborhood Hits	599	Target Neighborhood Hits	1103	Shared Neighborhood Hits	250
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

CT012_HUMAN
NC score	0.177035 (rank : 373)	θ value	1.81305 (rank : 432)
Query Neighborhood Hits	599	Target Neighborhood Hits	205	Shared Neighborhood Hits	147
SwissProt Accessions	Q9NVP4, Q4F7X1, Q5QPD9, Q5QPE0, Q68DN8, Q6ZMX9, Q96NF0, Q9H1E0, Q9H442	Gene names	C20orf12
Domain Architecture
Description	Protein C20orf12.

CT032_HUMAN
NC score	0.176652 (rank : 374)	θ value	1.81305 (rank : 433)
Query Neighborhood Hits	599	Target Neighborhood Hits	235	Shared Neighborhood Hits	134
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

NCF1_HUMAN
NC score	0.176221 (rank : 375)	θ value	1.06291 (rank : 407)
Query Neighborhood Hits	599	Target Neighborhood Hits	198	Shared Neighborhood Hits	129
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

ARHG4_HUMAN
NC score	0.175360 (rank : 376)	θ value	0.0148317 (rank : 203)
Query Neighborhood Hits	599	Target Neighborhood Hits	242	Shared Neighborhood Hits	138
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

TRPV5_HUMAN
NC score	0.174139 (rank : 377)	θ value	θ > 10 (rank : 782)
Query Neighborhood Hits	599	Target Neighborhood Hits	261	Shared Neighborhood Hits	184
SwissProt Accessions	Q9NQA5, Q8NDW5, Q8NDX7, Q8NDX8, Q96PM6	Gene names	TRPV5, ECAC1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Calcium transport protein 2) (CaT2).

ABI3_MOUSE
NC score	0.172284 (rank : 378)	θ value	θ > 10 (rank : 603)
Query Neighborhood Hits	599	Target Neighborhood Hits	227	Shared Neighborhood Hits	130
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

TRPV6_HUMAN
NC score	0.169690 (rank : 379)	θ value	θ > 10 (rank : 784)
Query Neighborhood Hits	599	Target Neighborhood Hits	262	Shared Neighborhood Hits	184
SwissProt Accessions	Q9H1D0, Q8TDL3, Q8WXR8, Q96LC5, Q9H1D1, Q9H296	Gene names	TRPV6, ECAC2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1) (CaT-like) (CaT-L).

ARHG9_HUMAN
NC score	0.168151 (rank : 380)	θ value	0.0252991 (rank : 217)
Query Neighborhood Hits	599	Target Neighborhood Hits	235	Shared Neighborhood Hits	135
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

NCK2_HUMAN
NC score	0.168122 (rank : 381)	θ value	θ > 10 (rank : 701)
Query Neighborhood Hits	599	Target Neighborhood Hits	310	Shared Neighborhood Hits	147
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

ARHG9_MOUSE
NC score	0.167836 (rank : 382)	θ value	0.0252991 (rank : 218)
Query Neighborhood Hits	599	Target Neighborhood Hits	234	Shared Neighborhood Hits	134
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

VAV_HUMAN
NC score	0.165661 (rank : 383)	θ value	0.0330416 (rank : 236)
Query Neighborhood Hits	599	Target Neighborhood Hits	452	Shared Neighborhood Hits	158
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
NC score	0.165319 (rank : 384)	θ value	0.0736092 (rank : 272)
Query Neighborhood Hits	599	Target Neighborhood Hits	430	Shared Neighborhood Hits	158
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

NCF1_MOUSE
NC score	0.161633 (rank : 385)	θ value	θ > 10 (rank : 700)
Query Neighborhood Hits	599	Target Neighborhood Hits	198	Shared Neighborhood Hits	132
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NEBU_HUMAN
NC score	0.160560 (rank : 386)	θ value	0.0330416 (rank : 235)
Query Neighborhood Hits	599	Target Neighborhood Hits	420	Shared Neighborhood Hits	148
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

ANKR9_HUMAN
NC score	0.158298 (rank : 387)	θ value	0.813845 (rank : 384)
Query Neighborhood Hits	599	Target Neighborhood Hits	99	Shared Neighborhood Hits	92
SwissProt Accessions	Q96BM1	Gene names	ANKRD9
Domain Architecture
Description	Ankyrin repeat domain-containing protein 9.

DGKZ_MOUSE
NC score	0.158133 (rank : 388)	θ value	θ > 10 (rank : 667)
Query Neighborhood Hits	599	Target Neighborhood Hits	542	Shared Neighborhood Hits	187
SwissProt Accessions	Q80UP3	Gene names	Dgkz
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

NOTC1_MOUSE
NC score	0.157314 (rank : 389)	θ value	0.0961366 (rank : 280)
Query Neighborhood Hits	599	Target Neighborhood Hits	916	Shared Neighborhood Hits	230
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

IKBL_MOUSE
NC score	0.148317 (rank : 390)	θ value	θ > 10 (rank : 685)
Query Neighborhood Hits	599	Target Neighborhood Hits	196	Shared Neighborhood Hits	138
SwissProt Accessions	O88995, Q91X16, Q9R1Y3	Gene names	Nfkbil1, Ikbl
Domain Architecture
Description	NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like) (I- kappa-B-like) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1).

IKBL_HUMAN
NC score	0.148159 (rank : 391)	θ value	θ > 10 (rank : 684)
Query Neighborhood Hits	599	Target Neighborhood Hits	168	Shared Neighborhood Hits	133
SwissProt Accessions	Q9UBC1, Q14625, Q9UBX4	Gene names	NFKBIL1, IKBL
Domain Architecture
Description	NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like) (I- kappa-B-like) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1).

ARHG4_MOUSE
NC score	0.147817 (rank : 392)	θ value	0.21417 (rank : 318)
Query Neighborhood Hits	599	Target Neighborhood Hits	185	Shared Neighborhood Hits	104
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

RUSC1_HUMAN
NC score	0.146974 (rank : 393)	θ value	0.21417 (rank : 332)
Query Neighborhood Hits	599	Target Neighborhood Hits	226	Shared Neighborhood Hits	128
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

ANKZ1_MOUSE
NC score	0.145210 (rank : 394)	θ value	θ > 10 (rank : 618)
Query Neighborhood Hits	599	Target Neighborhood Hits	208	Shared Neighborhood Hits	137
SwissProt Accessions	Q80UU1, Q9CZF5	Gene names	Ankzf1, D1Ertd161e
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1.

RIMB2_HUMAN
NC score	0.143850 (rank : 395)	θ value	0.47712 (rank : 367)
Query Neighborhood Hits	599	Target Neighborhood Hits	263	Shared Neighborhood Hits	107
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

VAV2_MOUSE
NC score	0.143367 (rank : 396)	θ value	0.279714 (rank : 347)
Query Neighborhood Hits	599	Target Neighborhood Hits	456	Shared Neighborhood Hits	156
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV2_HUMAN
NC score	0.143189 (rank : 397)	θ value	0.365318 (rank : 360)
Query Neighborhood Hits	599	Target Neighborhood Hits	453	Shared Neighborhood Hits	156
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

TCGAP_HUMAN
NC score	0.140744 (rank : 398)	θ value	4.03905 (rank : 504)
Query Neighborhood Hits	599	Target Neighborhood Hits	872	Shared Neighborhood Hits	169
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

PLCG1_MOUSE
NC score	0.138812 (rank : 399)	θ value	0.21417 (rank : 328)
Query Neighborhood Hits	599	Target Neighborhood Hits	314	Shared Neighborhood Hits	133
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

CASL_HUMAN
NC score	0.138193 (rank : 400)	θ value	3.0926 (rank : 467)
Query Neighborhood Hits	599	Target Neighborhood Hits	259	Shared Neighborhood Hits	132
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

EFS_MOUSE
NC score	0.138046 (rank : 401)	θ value	θ > 10 (rank : 669)
Query Neighborhood Hits	599	Target Neighborhood Hits	389	Shared Neighborhood Hits	145
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

EFS_HUMAN
NC score	0.136477 (rank : 402)	θ value	θ > 10 (rank : 668)
Query Neighborhood Hits	599	Target Neighborhood Hits	348	Shared Neighborhood Hits	154
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

CASL_MOUSE
NC score	0.136373 (rank : 403)	θ value	8.99809 (rank : 565)
Query Neighborhood Hits	599	Target Neighborhood Hits	225	Shared Neighborhood Hits	133
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

ANKZ1_HUMAN
NC score	0.136026 (rank : 404)	θ value	θ > 10 (rank : 617)
Query Neighborhood Hits	599	Target Neighborhood Hits	236	Shared Neighborhood Hits	148
SwissProt Accessions	Q9H8Y5, Q9NVZ4	Gene names	ANKZF1, ZNF744
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1 (Zinc finger protein 744).

TCGAP_MOUSE
NC score	0.134639 (rank : 405)	θ value	4.03905 (rank : 505)
Query Neighborhood Hits	599	Target Neighborhood Hits	409	Shared Neighborhood Hits	143
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

AMPH_HUMAN
NC score	0.134634 (rank : 406)	θ value	0.0113563 (rank : 192)
Query Neighborhood Hits	599	Target Neighborhood Hits	455	Shared Neighborhood Hits	119
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

RHG04_HUMAN
NC score	0.132127 (rank : 407)	θ value	θ > 10 (rank : 733)
Query Neighborhood Hits	599	Target Neighborhood Hits	307	Shared Neighborhood Hits	143
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

PLCG2_HUMAN
NC score	0.131943 (rank : 408)	θ value	1.06291 (rank : 409)
Query Neighborhood Hits	599	Target Neighborhood Hits	280	Shared Neighborhood Hits	120
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

RUSC1_MOUSE
NC score	0.130991 (rank : 409)	θ value	0.813845 (rank : 396)
Query Neighborhood Hits	599	Target Neighborhood Hits	206	Shared Neighborhood Hits	116
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

NPHP1_MOUSE
NC score	0.130643 (rank : 410)	θ value	θ > 10 (rank : 707)
Query Neighborhood Hits	599	Target Neighborhood Hits	267	Shared Neighborhood Hits	134
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

PLCG1_HUMAN
NC score	0.128808 (rank : 411)	θ value	1.38821 (rank : 423)
Query Neighborhood Hits	599	Target Neighborhood Hits	293	Shared Neighborhood Hits	124
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PEX13_MOUSE
NC score	0.125970 (rank : 412)	θ value	θ > 10 (rank : 712)
Query Neighborhood Hits	599	Target Neighborhood Hits	126	Shared Neighborhood Hits	94
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

VAV3_HUMAN
NC score	0.124586 (rank : 413)	θ value	θ > 10 (rank : 786)
Query Neighborhood Hits	599	Target Neighborhood Hits	398	Shared Neighborhood Hits	144
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

MYO1F_MOUSE
NC score	0.123716 (rank : 414)	θ value	0.000158464 (rank : 78)
Query Neighborhood Hits	599	Target Neighborhood Hits	262	Shared Neighborhood Hits	148
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

AMPH_MOUSE
NC score	0.122807 (rank : 415)	θ value	0.0736092 (rank : 259)
Query Neighborhood Hits	599	Target Neighborhood Hits	291	Shared Neighborhood Hits	105
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

MYO1F_HUMAN
NC score	0.122219 (rank : 416)	θ value	0.00134147 (rank : 130)
Query Neighborhood Hits	599	Target Neighborhood Hits	275	Shared Neighborhood Hits	158
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

VAV3_MOUSE
NC score	0.122213 (rank : 417)	θ value	θ > 10 (rank : 787)
Query Neighborhood Hits	599	Target Neighborhood Hits	404	Shared Neighborhood Hits	141
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

MYO1E_HUMAN
NC score	0.122146 (rank : 418)	θ value	5.44631e-05 (rank : 56)
Query Neighborhood Hits	599	Target Neighborhood Hits	293	Shared Neighborhood Hits	150
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

OSBP1_HUMAN
NC score	0.121536 (rank : 419)	θ value	9.29e-05 (rank : 65)
Query Neighborhood Hits	599	Target Neighborhood Hits	180	Shared Neighborhood Hits	46
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

RIMB2_MOUSE
NC score	0.120987 (rank : 420)	θ value	θ > 10 (rank : 744)
Query Neighborhood Hits	599	Target Neighborhood Hits	246	Shared Neighborhood Hits	103
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

PEX13_HUMAN
NC score	0.120049 (rank : 421)	θ value	θ > 10 (rank : 711)
Query Neighborhood Hits	599	Target Neighborhood Hits	128	Shared Neighborhood Hits	93
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

ES8L3_MOUSE
NC score	0.119290 (rank : 422)	θ value	5.27518 (rank : 512)
Query Neighborhood Hits	599	Target Neighborhood Hits	168	Shared Neighborhood Hits	107
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

SRGP2_MOUSE
NC score	0.118956 (rank : 423)	θ value	8.99809 (rank : 595)
Query Neighborhood Hits	599	Target Neighborhood Hits	324	Shared Neighborhood Hits	147
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

NPHP1_HUMAN
NC score	0.118288 (rank : 424)	θ value	θ > 10 (rank : 706)
Query Neighborhood Hits	599	Target Neighborhood Hits	288	Shared Neighborhood Hits	129
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

SHLB1_MOUSE
NC score	0.118281 (rank : 425)	θ value	θ > 10 (rank : 753)
Query Neighborhood Hits	599	Target Neighborhood Hits	101	Shared Neighborhood Hits	76
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SRGP2_HUMAN
NC score	0.117901 (rank : 426)	θ value	θ > 10 (rank : 763)
Query Neighborhood Hits	599	Target Neighborhood Hits	331	Shared Neighborhood Hits	145
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

CLR59_HUMAN
NC score	0.117753 (rank : 427)	θ value	θ > 10 (rank : 658)
Query Neighborhood Hits	599	Target Neighborhood Hits	163	Shared Neighborhood Hits	131
SwissProt Accessions	Q96DZ5, Q8WWL1, Q96C99, Q9UFT7	Gene names	CLIPR59
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 170-related 59 kDa protein (CLIPR-59) (CLIP-170-related 59 kDa protein).

ES8L3_HUMAN
NC score	0.117319 (rank : 428)	θ value	0.163984 (rank : 309)
Query Neighborhood Hits	599	Target Neighborhood Hits	206	Shared Neighborhood Hits	93
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FNBP2_HUMAN
NC score	0.116029 (rank : 429)	θ value	θ > 10 (rank : 677)
Query Neighborhood Hits	599	Target Neighborhood Hits	432	Shared Neighborhood Hits	164
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

ABTB1_MOUSE
NC score	0.115615 (rank : 430)	θ value	θ > 10 (rank : 606)
Query Neighborhood Hits	599	Target Neighborhood Hits	349	Shared Neighborhood Hits	151
SwissProt Accessions	Q99LJ2, Q8C2K7, Q91XU4	Gene names	Abtb1, Bpoz
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 1.

JIP2_HUMAN
NC score	0.114954 (rank : 431)	θ value	0.0113563 (rank : 196)
Query Neighborhood Hits	599	Target Neighborhood Hits	288	Shared Neighborhood Hits	94
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

BAT4_HUMAN
NC score	0.112948 (rank : 432)	θ value	θ > 10 (rank : 642)
Query Neighborhood Hits	599	Target Neighborhood Hits	157	Shared Neighborhood Hits	97
SwissProt Accessions	O95872	Gene names	BAT4, G5
Domain Architecture
Description	Protein BAT4 (HLA-B-associated transcript 4) (G5 protein).

SRGP1_HUMAN
NC score	0.112627 (rank : 433)	θ value	θ > 10 (rank : 762)
Query Neighborhood Hits	599	Target Neighborhood Hits	390	Shared Neighborhood Hits	151
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

BAT4_MOUSE
NC score	0.111531 (rank : 434)	θ value	θ > 10 (rank : 643)
Query Neighborhood Hits	599	Target Neighborhood Hits	171	Shared Neighborhood Hits	109
SwissProt Accessions	Q61858, Q9R065	Gene names	Bat4, Bat-4, G5
Domain Architecture
Description	Protein BAT4 (HLA-B-associated transcript 4) (G5 protein).

BIN1_HUMAN
NC score	0.110092 (rank : 435)	θ value	4.03905 (rank : 489)
Query Neighborhood Hits	599	Target Neighborhood Hits	335	Shared Neighborhood Hits	115
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

RIMB1_HUMAN
NC score	0.109582 (rank : 436)	θ value	0.21417 (rank : 330)
Query Neighborhood Hits	599	Target Neighborhood Hits	1479	Shared Neighborhood Hits	215
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

ES8L2_HUMAN
NC score	0.108885 (rank : 437)	θ value	1.38821 (rank : 420)
Query Neighborhood Hits	599	Target Neighborhood Hits	193	Shared Neighborhood Hits	98
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

PKHA1_HUMAN
NC score	0.108572 (rank : 438)	θ value	6.88961 (rank : 551)
Query Neighborhood Hits	599	Target Neighborhood Hits	127	Shared Neighborhood Hits	41
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

ES8L2_MOUSE
NC score	0.107321 (rank : 439)	θ value	0.279714 (rank : 340)
Query Neighborhood Hits	599	Target Neighborhood Hits	169	Shared Neighborhood Hits	92
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

EPS8_MOUSE
NC score	0.105706 (rank : 440)	θ value	0.163984 (rank : 308)
Query Neighborhood Hits	599	Target Neighborhood Hits	157	Shared Neighborhood Hits	101
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

SHLB1_HUMAN
NC score	0.105019 (rank : 441)	θ value	θ > 10 (rank : 752)
Query Neighborhood Hits	599	Target Neighborhood Hits	96	Shared Neighborhood Hits	72
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

PKHA6_MOUSE
NC score	0.104445 (rank : 442)	θ value	θ > 10 (rank : 718)
Query Neighborhood Hits	599	Target Neighborhood Hits	591	Shared Neighborhood Hits	97
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

STS2_HUMAN
NC score	0.104192 (rank : 443)	θ value	0.279714 (rank : 345)
Query Neighborhood Hits	599	Target Neighborhood Hits	108	Shared Neighborhood Hits	80
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

JIP2_MOUSE
NC score	0.103465 (rank : 444)	θ value	0.0113563 (rank : 197)
Query Neighborhood Hits	599	Target Neighborhood Hits	144	Shared Neighborhood Hits	64
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

ARHG5_HUMAN
NC score	0.103459 (rank : 445)	θ value	1.81305 (rank : 430)
Query Neighborhood Hits	599	Target Neighborhood Hits	172	Shared Neighborhood Hits	89
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

PKHA1_MOUSE
NC score	0.102823 (rank : 446)	θ value	6.88961 (rank : 552)
Query Neighborhood Hits	599	Target Neighborhood Hits	120	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

OSBL3_HUMAN
NC score	0.102741 (rank : 447)	θ value	0.000602161 (rank : 105)
Query Neighborhood Hits	599	Target Neighborhood Hits	93	Shared Neighborhood Hits	30
SwissProt Accessions	Q9H4L5, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9UED6	Gene names	OSBPL3, KIAA0704, ORP3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

ABTB1_HUMAN
NC score	0.101750 (rank : 448)	θ value	θ > 10 (rank : 605)
Query Neighborhood Hits	599	Target Neighborhood Hits	325	Shared Neighborhood Hits	141
SwissProt Accessions	Q969K4, Q6ZNU9, Q71MF1, Q96S62, Q96S63	Gene names	ABTB1, BPOZ
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 1 (Elongation factor 1A-binding protein).

ARHGG_MOUSE
NC score	0.101390 (rank : 449)	θ value	1.38821 (rank : 414)
Query Neighborhood Hits	599	Target Neighborhood Hits	152	Shared Neighborhood Hits	75
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

SNX9_HUMAN
NC score	0.100997 (rank : 450)	θ value	θ > 10 (rank : 758)
Query Neighborhood Hits	599	Target Neighborhood Hits	148	Shared Neighborhood Hits	79
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

EPS8_HUMAN
NC score	0.100932 (rank : 451)	θ value	0.62314 (rank : 374)
Query Neighborhood Hits	599	Target Neighborhood Hits	151	Shared Neighborhood Hits	96
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

BI2L1_HUMAN
NC score	0.099915 (rank : 452)	θ value	4.03905 (rank : 488)
Query Neighborhood Hits	599	Target Neighborhood Hits	156	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

OSBL3_MOUSE
NC score	0.099468 (rank : 453)	θ value	0.0252991 (rank : 221)
Query Neighborhood Hits	599	Target Neighborhood Hits	86	Shared Neighborhood Hits	27
SwissProt Accessions	Q9DBS9	Gene names	Osbpl3, Orp3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

SPTA2_HUMAN
NC score	0.099396 (rank : 454)	θ value	0.62314 (rank : 380)
Query Neighborhood Hits	599	Target Neighborhood Hits	888	Shared Neighborhood Hits	189
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

NOXO1_MOUSE
NC score	0.098131 (rank : 455)	θ value	θ > 10 (rank : 705)
Query Neighborhood Hits	599	Target Neighborhood Hits	114	Shared Neighborhood Hits	80
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

BIN1_MOUSE
NC score	0.097435 (rank : 456)	θ value	4.03905 (rank : 490)
Query Neighborhood Hits	599	Target Neighborhood Hits	283	Shared Neighborhood Hits	118
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

RIMB1_MOUSE
NC score	0.097164 (rank : 457)	θ value	0.125558 (rank : 297)
Query Neighborhood Hits	599	Target Neighborhood Hits	1376	Shared Neighborhood Hits	210
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

DAPP1_MOUSE
NC score	0.096729 (rank : 458)	θ value	0.62314 (rank : 373)
Query Neighborhood Hits	599	Target Neighborhood Hits	225	Shared Neighborhood Hits	56
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PKHA6_HUMAN
NC score	0.095931 (rank : 459)	θ value	θ > 10 (rank : 717)
Query Neighborhood Hits	599	Target Neighborhood Hits	556	Shared Neighborhood Hits	93
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

SPTA1_HUMAN
NC score	0.094886 (rank : 460)	θ value	0.21417 (rank : 333)
Query Neighborhood Hits	599	Target Neighborhood Hits	748	Shared Neighborhood Hits	176
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

TRPV1_MOUSE
NC score	0.094792 (rank : 461)	θ value	θ > 10 (rank : 777)
Query Neighborhood Hits	599	Target Neighborhood Hits	189	Shared Neighborhood Hits	133
SwissProt Accessions	Q704Y3, Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0	Gene names	Trpv1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).

BI2L1_MOUSE
NC score	0.091534 (rank : 462)	θ value	0.813845 (rank : 389)
Query Neighborhood Hits	599	Target Neighborhood Hits	197	Shared Neighborhood Hits	66
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

GSCR1_HUMAN
NC score	0.091432 (rank : 463)	θ value	0.0193708 (rank : 211)
Query Neighborhood Hits	599	Target Neighborhood Hits	674	Shared Neighborhood Hits	112
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

TRPV1_HUMAN
NC score	0.091300 (rank : 464)	θ value	θ > 10 (rank : 776)
Query Neighborhood Hits	599	Target Neighborhood Hits	184	Shared Neighborhood Hits	130
SwissProt Accessions	Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22	Gene names	TRPV1, VR1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Capsaicin receptor).

RHG09_HUMAN
NC score	0.090060 (rank : 465)	θ value	0.0563607 (rank : 258)
Query Neighborhood Hits	599	Target Neighborhood Hits	186	Shared Neighborhood Hits	47
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

DOCK1_HUMAN
NC score	0.090054 (rank : 466)	θ value	0.0563607 (rank : 252)
Query Neighborhood Hits	599	Target Neighborhood Hits	191	Shared Neighborhood Hits	101
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

SNX9_MOUSE
NC score	0.088969 (rank : 467)	θ value	θ > 10 (rank : 759)
Query Neighborhood Hits	599	Target Neighborhood Hits	141	Shared Neighborhood Hits	72
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

NGEF_HUMAN
NC score	0.088966 (rank : 468)	θ value	5.27518 (rank : 522)
Query Neighborhood Hits	599	Target Neighborhood Hits	166	Shared Neighborhood Hits	81
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ANM2_HUMAN
NC score	0.087397 (rank : 469)	θ value	θ > 10 (rank : 619)
Query Neighborhood Hits	599	Target Neighborhood Hits	175	Shared Neighborhood Hits	116
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

RSNL2_HUMAN
NC score	0.087271 (rank : 470)	θ value	θ > 10 (rank : 746)
Query Neighborhood Hits	599	Target Neighborhood Hits	136	Shared Neighborhood Hits	105
SwissProt Accessions	Q8N3C7, Q7Z4U3, Q96BR7, Q96MA5, Q9H7C0	Gene names	RSNL2
Domain Architecture	No domain graphic available
Description	Restin-like protein 2.

DAPP1_HUMAN
NC score	0.086945 (rank : 471)	θ value	4.03905 (rank : 492)
Query Neighborhood Hits	599	Target Neighborhood Hits	227	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

SPTA1_MOUSE
NC score	0.086833 (rank : 472)	θ value	8.99809 (rank : 594)
Query Neighborhood Hits	599	Target Neighborhood Hits	675	Shared Neighborhood Hits	168
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SHLB2_MOUSE
NC score	0.086710 (rank : 473)	θ value	θ > 10 (rank : 755)
Query Neighborhood Hits	599	Target Neighborhood Hits	88	Shared Neighborhood Hits	60
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_HUMAN
NC score	0.085993 (rank : 474)	θ value	θ > 10 (rank : 754)
Query Neighborhood Hits	599	Target Neighborhood Hits	86	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

OSBP2_HUMAN
NC score	0.085670 (rank : 475)	θ value	0.21417 (rank : 326)
Query Neighborhood Hits	599	Target Neighborhood Hits	154	Shared Neighborhood Hits	39
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

NGEF_MOUSE
NC score	0.085377 (rank : 476)	θ value	θ > 10 (rank : 703)
Query Neighborhood Hits	599	Target Neighborhood Hits	228	Shared Neighborhood Hits	90
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

BCR_HUMAN
NC score	0.085010 (rank : 477)	θ value	θ > 10 (rank : 644)
Query Neighborhood Hits	599	Target Neighborhood Hits	204	Shared Neighborhood Hits	51
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

SHAN2_MOUSE
NC score	0.084547 (rank : 478)	θ value	θ > 10 (rank : 751)
Query Neighborhood Hits	599	Target Neighborhood Hits	446	Shared Neighborhood Hits	127
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

ANM2_MOUSE
NC score	0.083650 (rank : 479)	θ value	θ > 10 (rank : 620)
Query Neighborhood Hits	599	Target Neighborhood Hits	175	Shared Neighborhood Hits	111
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

OSBP2_MOUSE
NC score	0.083483 (rank : 480)	θ value	0.0961366 (rank : 281)
Query Neighborhood Hits	599	Target Neighborhood Hits	150	Shared Neighborhood Hits	39
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

PCLO_HUMAN
NC score	0.082972 (rank : 481)	θ value	0.00175202 (rank : 137)
Query Neighborhood Hits	599	Target Neighborhood Hits	2046	Shared Neighborhood Hits	205
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

FGD4_MOUSE
NC score	0.082608 (rank : 482)	θ value	0.47712 (rank : 363)
Query Neighborhood Hits	599	Target Neighborhood Hits	227	Shared Neighborhood Hits	61
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

NACAM_MOUSE
NC score	0.081840 (rank : 483)	θ value	0.125558 (rank : 294)
Query Neighborhood Hits	599	Target Neighborhood Hits	1866	Shared Neighborhood Hits	167
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

ES8L1_HUMAN
NC score	0.081273 (rank : 484)	θ value	θ > 10 (rank : 671)
Query Neighborhood Hits	599	Target Neighborhood Hits	162	Shared Neighborhood Hits	91
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

BAIP2_HUMAN
NC score	0.081251 (rank : 485)	θ value	5.27518 (rank : 507)
Query Neighborhood Hits	599	Target Neighborhood Hits	192	Shared Neighborhood Hits	73
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
NC score	0.081149 (rank : 486)	θ value	5.27518 (rank : 508)
Query Neighborhood Hits	599	Target Neighborhood Hits	185	Shared Neighborhood Hits	70
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BSN_MOUSE
NC score	0.080556 (rank : 487)	θ value	0.813845 (rank : 390)
Query Neighborhood Hits	599	Target Neighborhood Hits	2057	Shared Neighborhood Hits	203
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

PKHA2_MOUSE
NC score	0.079835 (rank : 488)	θ value	θ > 10 (rank : 714)
Query Neighborhood Hits	599	Target Neighborhood Hits	116	Shared Neighborhood Hits	41
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

3BP1_HUMAN
NC score	0.078960 (rank : 489)	θ value	θ > 10 (rank : 600)
Query Neighborhood Hits	599	Target Neighborhood Hits	376	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

NCOA6_MOUSE
NC score	0.078808 (rank : 490)	θ value	0.0193708 (rank : 212)
Query Neighborhood Hits	599	Target Neighborhood Hits	1076	Shared Neighborhood Hits	120
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

ES8L1_MOUSE
NC score	0.078400 (rank : 491)	θ value	θ > 10 (rank : 672)
Query Neighborhood Hits	599	Target Neighborhood Hits	143	Shared Neighborhood Hits	75
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

P85A_MOUSE
NC score	0.078389 (rank : 492)	θ value	θ > 10 (rank : 710)
Query Neighborhood Hits	599	Target Neighborhood Hits	435	Shared Neighborhood Hits	116
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_HUMAN
NC score	0.077777 (rank : 493)	θ value	θ > 10 (rank : 709)
Query Neighborhood Hits	599	Target Neighborhood Hits	479	Shared Neighborhood Hits	116
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

CMTA1_HUMAN
NC score	0.077274 (rank : 494)	θ value	θ > 10 (rank : 659)
Query Neighborhood Hits	599	Target Neighborhood Hits	217	Shared Neighborhood Hits	98
SwissProt Accessions	Q9Y6Y1, Q5VUE1	Gene names	CAMTA1, KIAA0833
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 1.

RSNL2_MOUSE
NC score	0.076797 (rank : 495)	θ value	θ > 10 (rank : 747)
Query Neighborhood Hits	599	Target Neighborhood Hits	129	Shared Neighborhood Hits	91
SwissProt Accessions	Q8CI96, Q8BW09, Q921Q4, Q9D2S6	Gene names	Rsnl2
Domain Architecture	No domain graphic available
Description	Restin-like protein 2.

ABR_HUMAN
NC score	0.076311 (rank : 496)	θ value	θ > 10 (rank : 604)
Query Neighborhood Hits	599	Target Neighborhood Hits	166	Shared Neighborhood Hits	41
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

PKHA2_HUMAN
NC score	0.076277 (rank : 497)	θ value	θ > 10 (rank : 713)
Query Neighborhood Hits	599	Target Neighborhood Hits	119	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

ARHGG_HUMAN
NC score	0.075444 (rank : 498)	θ value	5.27518 (rank : 506)
Query Neighborhood Hits	599	Target Neighborhood Hits	129	Shared Neighborhood Hits	58
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

WASIP_HUMAN
NC score	0.074548 (rank : 499)	θ value	θ > 10 (rank : 788)
Query Neighborhood Hits	599	Target Neighborhood Hits	458	Shared Neighborhood Hits	92
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

SPN90_HUMAN
NC score	0.073960 (rank : 500)	θ value	θ > 10 (rank : 760)
Query Neighborhood Hits	599	Target Neighborhood Hits	157	Shared Neighborhood Hits	83
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

NOXO1_HUMAN
NC score	0.073722 (rank : 501)	θ value	θ > 10 (rank : 704)
Query Neighborhood Hits	599	Target Neighborhood Hits	100	Shared Neighborhood Hits	72
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

OSBL6_HUMAN
NC score	0.073665 (rank : 502)	θ value	3.0926 (rank : 478)
Query Neighborhood Hits	599	Target Neighborhood Hits	101	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BZF3, Q7Z4Q1, Q96SR1	Gene names	OSBPL6, ORP6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

TRPV3_MOUSE
NC score	0.073400 (rank : 503)	θ value	θ > 10 (rank : 781)
Query Neighborhood Hits	599	Target Neighborhood Hits	188	Shared Neighborhood Hits	107
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

OSBL6_MOUSE
NC score	0.072852 (rank : 504)	θ value	4.03905 (rank : 499)
Query Neighborhood Hits	599	Target Neighborhood Hits	105	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BXR9, Q8BYW2	Gene names	Osbpl6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

TRPV3_HUMAN
NC score	0.072668 (rank : 505)	θ value	θ > 10 (rank : 780)
Query Neighborhood Hits	599	Target Neighborhood Hits	198	Shared Neighborhood Hits	117
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

TRPV2_HUMAN
NC score	0.070476 (rank : 506)	θ value	θ > 10 (rank : 778)
Query Neighborhood Hits	599	Target Neighborhood Hits	130	Shared Neighborhood Hits	98
SwissProt Accessions	Q9Y5S1, Q9Y670	Gene names	TRPV2, VRL
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1).

RHG12_MOUSE
NC score	0.069091 (rank : 507)	θ value	θ > 10 (rank : 739)
Query Neighborhood Hits	599	Target Neighborhood Hits	204	Shared Neighborhood Hits	53
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

OSBL9_HUMAN
NC score	0.069028 (rank : 508)	θ value	8.99809 (rank : 586)
Query Neighborhood Hits	599	Target Neighborhood Hits	138	Shared Neighborhood Hits	43
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

PKHG1_HUMAN
NC score	0.068831 (rank : 509)	θ value	θ > 10 (rank : 719)
Query Neighborhood Hits	599	Target Neighborhood Hits	174	Shared Neighborhood Hits	33
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

RGS3_MOUSE
NC score	0.068621 (rank : 510)	θ value	0.0113563 (rank : 199)
Query Neighborhood Hits	599	Target Neighborhood Hits	1621	Shared Neighborhood Hits	150
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

TIAM1_MOUSE
NC score	0.068319 (rank : 511)	θ value	8.99809 (rank : 598)
Query Neighborhood Hits	599	Target Neighborhood Hits	205	Shared Neighborhood Hits	37
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TARSH_HUMAN
NC score	0.068190 (rank : 512)	θ value	0.21417 (rank : 336)
Query Neighborhood Hits	599	Target Neighborhood Hits	768	Shared Neighborhood Hits	96
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

MDC1_HUMAN
NC score	0.068091 (rank : 513)	θ value	1.38821 (rank : 422)
Query Neighborhood Hits	599	Target Neighborhood Hits	1446	Shared Neighborhood Hits	135
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

SPN90_MOUSE
NC score	0.068058 (rank : 514)	θ value	θ > 10 (rank : 761)
Query Neighborhood Hits	599	Target Neighborhood Hits	157	Shared Neighborhood Hits	79
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

RBP1_MOUSE
NC score	0.067844 (rank : 515)	θ value	θ > 10 (rank : 730)
Query Neighborhood Hits	599	Target Neighborhood Hits	493	Shared Neighborhood Hits	63
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

K1543_MOUSE
NC score	0.067836 (rank : 516)	θ value	0.62314 (rank : 376)
Query Neighborhood Hits	599	Target Neighborhood Hits	497	Shared Neighborhood Hits	77
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

FGD4_HUMAN
NC score	0.067672 (rank : 517)	θ value	3.0926 (rank : 473)
Query Neighborhood Hits	599	Target Neighborhood Hits	219	Shared Neighborhood Hits	52
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

CK024_HUMAN
NC score	0.067462 (rank : 518)	θ value	0.47712 (rank : 362)
Query Neighborhood Hits	599	Target Neighborhood Hits	408	Shared Neighborhood Hits	69
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

RBP1_HUMAN
NC score	0.067306 (rank : 519)	θ value	θ > 10 (rank : 729)
Query Neighborhood Hits	599	Target Neighborhood Hits	521	Shared Neighborhood Hits	65
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RUSC2_HUMAN
NC score	0.066653 (rank : 520)	θ value	8.99809 (rank : 591)
Query Neighborhood Hits	599	Target Neighborhood Hits	205	Shared Neighborhood Hits	79
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

PREX1_HUMAN
NC score	0.066624 (rank : 521)	θ value	θ > 10 (rank : 723)
Query Neighborhood Hits	599	Target Neighborhood Hits	177	Shared Neighborhood Hits	30
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

CU081_HUMAN
NC score	0.066523 (rank : 522)	θ value	θ > 10 (rank : 664)
Query Neighborhood Hits	599	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NFU9	Gene names	C21orf81
Domain Architecture	No domain graphic available
Description	Protein C21orf81.

PRP2_MOUSE
NC score	0.066423 (rank : 523)	θ value	θ > 10 (rank : 726)
Query Neighborhood Hits	599	Target Neighborhood Hits	347	Shared Neighborhood Hits	80
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

PCLO_MOUSE
NC score	0.066339 (rank : 524)	θ value	0.813845 (rank : 393)
Query Neighborhood Hits	599	Target Neighborhood Hits	2275	Shared Neighborhood Hits	202
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

BAT2_HUMAN
NC score	0.065984 (rank : 525)	θ value	5.27518 (rank : 509)
Query Neighborhood Hits	599	Target Neighborhood Hits	931	Shared Neighborhood Hits	114
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

RHG12_HUMAN
NC score	0.065908 (rank : 526)	θ value	θ > 10 (rank : 738)
Query Neighborhood Hits	599	Target Neighborhood Hits	190	Shared Neighborhood Hits	44
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

FGD1_HUMAN
NC score	0.065851 (rank : 527)	θ value	θ > 10 (rank : 673)
Query Neighborhood Hits	599	Target Neighborhood Hits	367	Shared Neighborhood Hits	92
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

RUSC2_MOUSE
NC score	0.065585 (rank : 528)	θ value	3.0926 (rank : 482)
Query Neighborhood Hits	599	Target Neighborhood Hits	305	Shared Neighborhood Hits	89
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

MUC7_HUMAN
NC score	0.065196 (rank : 529)	θ value	θ > 10 (rank : 697)
Query Neighborhood Hits	599	Target Neighborhood Hits	538	Shared Neighborhood Hits	97
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

TIAM1_HUMAN
NC score	0.064987 (rank : 530)	θ value	θ > 10 (rank : 775)
Query Neighborhood Hits	599	Target Neighborhood Hits	225	Shared Neighborhood Hits	37
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG8_MOUSE
NC score	0.064048 (rank : 531)	θ value	θ > 10 (rank : 631)
Query Neighborhood Hits	599	Target Neighborhood Hits	79	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGF_HUMAN
NC score	0.064035 (rank : 532)	θ value	θ > 10 (rank : 634)
Query Neighborhood Hits	599	Target Neighborhood Hits	214	Shared Neighborhood Hits	71
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

PKHA4_HUMAN
NC score	0.063965 (rank : 533)	θ value	θ > 10 (rank : 715)
Query Neighborhood Hits	599	Target Neighborhood Hits	283	Shared Neighborhood Hits	73
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

3BP1_MOUSE
NC score	0.063892 (rank : 534)	θ value	θ > 10 (rank : 601)
Query Neighborhood Hits	599	Target Neighborhood Hits	238	Shared Neighborhood Hits	75
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

WASIP_MOUSE
NC score	0.063722 (rank : 535)	θ value	θ > 10 (rank : 789)
Query Neighborhood Hits	599	Target Neighborhood Hits	392	Shared Neighborhood Hits	92
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

MYO10_HUMAN
NC score	0.063634 (rank : 536)	θ value	0.21417 (rank : 325)
Query Neighborhood Hits	599	Target Neighborhood Hits	920	Shared Neighborhood Hits	108
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

CMTA2_HUMAN
NC score	0.063525 (rank : 537)	θ value	θ > 10 (rank : 660)
Query Neighborhood Hits	599	Target Neighborhood Hits	199	Shared Neighborhood Hits	101
SwissProt Accessions	O94983, Q7Z6M8, Q8N3V0, Q8NDG4, Q96G17	Gene names	CAMTA2, KIAA0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

JIP1_HUMAN
NC score	0.063085 (rank : 538)	θ value	θ > 10 (rank : 686)
Query Neighborhood Hits	599	Target Neighborhood Hits	271	Shared Neighborhood Hits	68
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

ARHG3_HUMAN
NC score	0.063079 (rank : 539)	θ value	θ > 10 (rank : 628)
Query Neighborhood Hits	599	Target Neighborhood Hits	82	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.062984 (rank : 540)	θ value	θ > 10 (rank : 629)
Query Neighborhood Hits	599	Target Neighborhood Hits	85	Shared Neighborhood Hits	26
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

PRRT3_HUMAN
NC score	0.062658 (rank : 541)	θ value	0.125558 (rank : 296)
Query Neighborhood Hits	599	Target Neighborhood Hits	998	Shared Neighborhood Hits	89
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

RGAP1_MOUSE
NC score	0.062385 (rank : 542)	θ value	θ > 10 (rank : 732)
Query Neighborhood Hits	599	Target Neighborhood Hits	185	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

BSN_HUMAN
NC score	0.062341 (rank : 543)	θ value	6.88961 (rank : 534)
Query Neighborhood Hits	599	Target Neighborhood Hits	1537	Shared Neighborhood Hits	173
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

FGD1_MOUSE
NC score	0.062187 (rank : 544)	θ value	θ > 10 (rank : 674)
Query Neighborhood Hits	599	Target Neighborhood Hits	387	Shared Neighborhood Hits	80
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

JIP1_MOUSE
NC score	0.062086 (rank : 545)	θ value	θ > 10 (rank : 687)
Query Neighborhood Hits	599	Target Neighborhood Hits	259	Shared Neighborhood Hits	68
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

STS1_HUMAN
NC score	0.061807 (rank : 546)	θ value	θ > 10 (rank : 767)
Query Neighborhood Hits	599	Target Neighborhood Hits	106	Shared Neighborhood Hits	68
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

PKHA5_HUMAN
NC score	0.061767 (rank : 547)	θ value	3.0926 (rank : 480)
Query Neighborhood Hits	599	Target Neighborhood Hits	455	Shared Neighborhood Hits	68
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

RHG25_MOUSE
NC score	0.061650 (rank : 548)	θ value	θ > 10 (rank : 743)
Query Neighborhood Hits	599	Target Neighborhood Hits	492	Shared Neighborhood Hits	75
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

STS1_MOUSE
NC score	0.061528 (rank : 549)	θ value	θ > 10 (rank : 768)
Query Neighborhood Hits	599	Target Neighborhood Hits	104	Shared Neighborhood Hits	65
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

NCOA6_HUMAN
NC score	0.061409 (rank : 550)	θ value	θ > 10 (rank : 702)
Query Neighborhood Hits	599	Target Neighborhood Hits	1202	Shared Neighborhood Hits	118
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

PRR12_HUMAN
NC score	0.061302 (rank : 551)	θ value	θ > 10 (rank : 727)
Query Neighborhood Hits	599	Target Neighborhood Hits	460	Shared Neighborhood Hits	97
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

FARP1_HUMAN
NC score	0.061299 (rank : 552)	θ value	3.0926 (rank : 472)
Query Neighborhood Hits	599	Target Neighborhood Hits	241	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

CHIN_MOUSE
NC score	0.061256 (rank : 553)	θ value	θ > 10 (rank : 653)
Query Neighborhood Hits	599	Target Neighborhood Hits	229	Shared Neighborhood Hits	43
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

PRP1_HUMAN
NC score	0.061224 (rank : 554)	θ value	θ > 10 (rank : 725)
Query Neighborhood Hits	599	Target Neighborhood Hits	385	Shared Neighborhood Hits	77
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

OSBL7_HUMAN
NC score	0.061190 (rank : 555)	θ value	θ > 10 (rank : 708)
Query Neighborhood Hits	599	Target Neighborhood Hits	71	Shared Neighborhood Hits	19
SwissProt Accessions	Q9BZF2	Gene names	OSBPL7, ORP7
Domain Architecture
Description	Oxysterol-binding protein-related protein 7 (OSBP-related protein 7) (ORP-7).

DGKK_HUMAN
NC score	0.061131 (rank : 556)	θ value	θ > 10 (rank : 666)
Query Neighborhood Hits	599	Target Neighborhood Hits	378	Shared Neighborhood Hits	89
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

MCF2L_MOUSE
NC score	0.061083 (rank : 557)	θ value	θ > 10 (rank : 691)
Query Neighborhood Hits	599	Target Neighborhood Hits	255	Shared Neighborhood Hits	58
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

GMIP_MOUSE
NC score	0.061021 (rank : 558)	θ value	θ > 10 (rank : 682)
Query Neighborhood Hits	599	Target Neighborhood Hits	202	Shared Neighborhood Hits	30
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

SLY_MOUSE
NC score	0.060932 (rank : 559)	θ value	θ > 10 (rank : 757)
Query Neighborhood Hits	599	Target Neighborhood Hits	108	Shared Neighborhood Hits	58
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SASH1_MOUSE
NC score	0.060595 (rank : 560)	θ value	θ > 10 (rank : 749)
Query Neighborhood Hits	599	Target Neighborhood Hits	263	Shared Neighborhood Hits	77
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

CHIN_HUMAN
NC score	0.060503 (rank : 561)	θ value	θ > 10 (rank : 652)
Query Neighborhood Hits	599	Target Neighborhood Hits	227	Shared Neighborhood Hits	40
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
NC score	0.060258 (rank : 562)	θ value	θ > 10 (rank : 654)
Query Neighborhood Hits	599	Target Neighborhood Hits	220	Shared Neighborhood Hits	40
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

RGAP1_HUMAN
NC score	0.060255 (rank : 563)	θ value	θ > 10 (rank : 731)
Query Neighborhood Hits	599	Target Neighborhood Hits	189	Shared Neighborhood Hits	25
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

EM55_HUMAN
NC score	0.060232 (rank : 564)	θ value	2.36792 (rank : 448)
Query Neighborhood Hits	599	Target Neighborhood Hits	228	Shared Neighborhood Hits	80
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

SRRM1_MOUSE
NC score	0.060034 (rank : 565)	θ value	θ > 10 (rank : 765)
Query Neighborhood Hits	599	Target Neighborhood Hits	966	Shared Neighborhood Hits	118
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

SWP70_HUMAN
NC score	0.059966 (rank : 566)	θ value	8.99809 (rank : 596)
Query Neighborhood Hits	599	Target Neighborhood Hits	973	Shared Neighborhood Hits	114
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

MAGE1_HUMAN
NC score	0.059451 (rank : 567)	θ value	0.0148317 (rank : 208)
Query Neighborhood Hits	599	Target Neighborhood Hits	1389	Shared Neighborhood Hits	126
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

CMTA2_MOUSE
NC score	0.059359 (rank : 568)	θ value	θ > 10 (rank : 661)
Query Neighborhood Hits	599	Target Neighborhood Hits	216	Shared Neighborhood Hits	86
SwissProt Accessions	Q80Y50, Q3TFK0, Q5SX68, Q80TP1, Q8R0D9, Q8R2N5	Gene names	Camta2, Kiaa0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

TAF4_HUMAN
NC score	0.059314 (rank : 569)	θ value	θ > 10 (rank : 769)
Query Neighborhood Hits	599	Target Neighborhood Hits	687	Shared Neighborhood Hits	110
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

ANKF1_HUMAN
NC score	0.059051 (rank : 570)	θ value	θ > 10 (rank : 613)
Query Neighborhood Hits	599	Target Neighborhood Hits	126	Shared Neighborhood Hits	64
SwissProt Accessions	Q8N957	Gene names	ANKFN1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and fibronectin type-III domain-containing protein 1.

EM55_MOUSE
NC score	0.058757 (rank : 571)	θ value	5.27518 (rank : 511)
Query Neighborhood Hits	599	Target Neighborhood Hits	221	Shared Neighborhood Hits	79
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

SWP70_MOUSE
NC score	0.058687 (rank : 572)	θ value	8.99809 (rank : 597)
Query Neighborhood Hits	599	Target Neighborhood Hits	1097	Shared Neighborhood Hits	118
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

RAPH1_HUMAN
NC score	0.058196 (rank : 573)	θ value	θ > 10 (rank : 728)
Query Neighborhood Hits	599	Target Neighborhood Hits	593	Shared Neighborhood Hits	113
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

MKL1_MOUSE
NC score	0.058181 (rank : 574)	θ value	0.0148317 (rank : 209)
Query Neighborhood Hits	599	Target Neighborhood Hits	667	Shared Neighborhood Hits	74
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

ARHG8_HUMAN
NC score	0.058151 (rank : 575)	θ value	θ > 10 (rank : 630)
Query Neighborhood Hits	599	Target Neighborhood Hits	85	Shared Neighborhood Hits	26
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

GMIP_HUMAN
NC score	0.058009 (rank : 576)	θ value	θ > 10 (rank : 681)
Query Neighborhood Hits	599	Target Neighborhood Hits	225	Shared Neighborhood Hits	30
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

RHG25_HUMAN
NC score	0.057400 (rank : 577)	θ value	θ > 10 (rank : 742)
Query Neighborhood Hits	599	Target Neighborhood Hits	550	Shared Neighborhood Hits	83
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

CIP4_HUMAN
NC score	0.057163 (rank : 578)	θ value	θ > 10 (rank : 656)
Query Neighborhood Hits	599	Target Neighborhood Hits	374	Shared Neighborhood Hits	80
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

PRB4S_HUMAN
NC score	0.056982 (rank : 579)	θ value	θ > 10 (rank : 722)
Query Neighborhood Hits	599	Target Neighborhood Hits	330	Shared Neighborhood Hits	72
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

SRRM2_HUMAN
NC score	0.056767 (rank : 580)	θ value	θ > 10 (rank : 766)
Query Neighborhood Hits	599	Target Neighborhood Hits	1296	Shared Neighborhood Hits	131
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

OGFR_HUMAN
NC score	0.056592 (rank : 581)	θ value	6.88961 (rank : 550)
Query Neighborhood Hits	599	Target Neighborhood Hits	1582	Shared Neighborhood Hits	132
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

PKHA4_MOUSE
NC score	0.055953 (rank : 582)	θ value	θ > 10 (rank : 716)
Query Neighborhood Hits	599	Target Neighborhood Hits	202	Shared Neighborhood Hits	49
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

RHG05_MOUSE
NC score	0.055835 (rank : 583)	θ value	θ > 10 (rank : 735)
Query Neighborhood Hits	599	Target Neighborhood Hits	165	Shared Neighborhood Hits	21
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG05_HUMAN
NC score	0.055825 (rank : 584)	θ value	θ > 10 (rank : 734)
Query Neighborhood Hits	599	Target Neighborhood Hits	158	Shared Neighborhood Hits	19
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

GRLF1_HUMAN
NC score	0.055825 (rank : 585)	θ value	θ > 10 (rank : 683)
Query Neighborhood Hits	599	Target Neighborhood Hits	167	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

ARHGA_MOUSE
NC score	0.055769 (rank : 586)	θ value	θ > 10 (rank : 633)
Query Neighborhood Hits	599	Target Neighborhood Hits	125	Shared Neighborhood Hits	33
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

MYO9B_HUMAN
NC score	0.055661 (rank : 587)	θ value	θ > 10 (rank : 698)
Query Neighborhood Hits	599	Target Neighborhood Hits	641	Shared Neighborhood Hits	79
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

CHIO_MOUSE
NC score	0.055628 (rank : 588)	θ value	θ > 10 (rank : 655)
Query Neighborhood Hits	599	Target Neighborhood Hits	130	Shared Neighborhood Hits	21
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

SON_HUMAN
NC score	0.055615 (rank : 589)	θ value	3.0926 (rank : 483)
Query Neighborhood Hits	599	Target Neighborhood Hits	1568	Shared Neighborhood Hits	140
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

FGD6_HUMAN
NC score	0.055362 (rank : 590)	θ value	1.06291 (rank : 404)
Query Neighborhood Hits	599	Target Neighborhood Hits	237	Shared Neighborhood Hits	50
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

BAT2_MOUSE
NC score	0.055350 (rank : 591)	θ value	6.88961 (rank : 533)
Query Neighborhood Hits	599	Target Neighborhood Hits	947	Shared Neighborhood Hits	112
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

PELP1_MOUSE
NC score	0.055226 (rank : 592)	θ value	0.21417 (rank : 327)
Query Neighborhood Hits	599	Target Neighborhood Hits	709	Shared Neighborhood Hits	100
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

RHG06_HUMAN
NC score	0.055193 (rank : 593)	θ value	θ > 10 (rank : 736)
Query Neighborhood Hits	599	Target Neighborhood Hits	114	Shared Neighborhood Hits	22
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

TM108_MOUSE
NC score	0.054966 (rank : 594)	θ value	0.125558 (rank : 301)
Query Neighborhood Hits	599	Target Neighborhood Hits	336	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BHE4, Q80WR9	Gene names	Tmem108
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

M3KL4_HUMAN
NC score	0.054805 (rank : 595)	θ value	θ > 10 (rank : 690)
Query Neighborhood Hits	599	Target Neighborhood Hits	1087	Shared Neighborhood Hits	168
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

DGKH_HUMAN
NC score	0.054673 (rank : 596)	θ value	θ > 10 (rank : 665)
Query Neighborhood Hits	599	Target Neighborhood Hits	255	Shared Neighborhood Hits	52
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

MCF2_HUMAN
NC score	0.054147 (rank : 597)	θ value	θ > 10 (rank : 692)
Query Neighborhood Hits	599	Target Neighborhood Hits	166	Shared Neighborhood Hits	40
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

RHG18_HUMAN
NC score	0.053901 (rank : 598)	θ value	θ > 10 (rank : 740)
Query Neighborhood Hits	599	Target Neighborhood Hits	90	Shared Neighborhood Hits	14
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

SRRM1_HUMAN
NC score	0.053897 (rank : 599)	θ value	θ > 10 (rank : 764)
Query Neighborhood Hits	599	Target Neighborhood Hits	690	Shared Neighborhood Hits	95
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

SASH1_HUMAN
NC score	0.053872 (rank : 600)	θ value	θ > 10 (rank : 748)
Query Neighborhood Hits	599	Target Neighborhood Hits	292	Shared Neighborhood Hits	87
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

ARHGA_HUMAN
NC score	0.053831 (rank : 601)	θ value	θ > 10 (rank : 632)
Query Neighborhood Hits	599	Target Neighborhood Hits	187	Shared Neighborhood Hits	35
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

MDC1_MOUSE
NC score	0.053818 (rank : 602)	θ value	1.06291 (rank : 405)
Query Neighborhood Hits	599	Target Neighborhood Hits	998	Shared Neighborhood Hits	108
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

PPRB_MOUSE
NC score	0.053661 (rank : 603)	θ value	0.365318 (rank : 359)
Query Neighborhood Hits	599	Target Neighborhood Hits	354	Shared Neighborhood Hits	60
SwissProt Accessions	Q925J9, O88323, Q3UHV0, Q6AXD5, Q8BW37, Q8BX19, Q8VDQ7, Q925K0	Gene names	Pparbp, Trip2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2).

CJ078_MOUSE
NC score	0.053512 (rank : 604)	θ value	θ > 10 (rank : 657)
Query Neighborhood Hits	599	Target Neighborhood Hits	559	Shared Neighborhood Hits	88
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

TRPV2_MOUSE
NC score	0.053156 (rank : 605)	θ value	θ > 10 (rank : 779)
Query Neighborhood Hits	599	Target Neighborhood Hits	111	Shared Neighborhood Hits	79
SwissProt Accessions	Q9WTR1, Q99K71	Gene names	Trpv2, Grc
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Growth factor-regulated calcium channel) (GRC).

RHG06_MOUSE
NC score	0.053076 (rank : 606)	θ value	θ > 10 (rank : 737)
Query Neighborhood Hits	599	Target Neighborhood Hits	105	Shared Neighborhood Hits	13
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

PRG4_HUMAN
NC score	0.053020 (rank : 607)	θ value	θ > 10 (rank : 724)
Query Neighborhood Hits	599	Target Neighborhood Hits	764	Shared Neighborhood Hits	108
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

ENAH_MOUSE
NC score	0.052913 (rank : 608)	θ value	θ > 10 (rank : 670)
Query Neighborhood Hits	599	Target Neighborhood Hits	919	Shared Neighborhood Hits	140
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

TARA_HUMAN
NC score	0.052908 (rank : 609)	θ value	θ > 10 (rank : 771)
Query Neighborhood Hits	599	Target Neighborhood Hits	1626	Shared Neighborhood Hits	159
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

SLY_HUMAN
NC score	0.052883 (rank : 610)	θ value	θ > 10 (rank : 756)
Query Neighborhood Hits	599	Target Neighborhood Hits	81	Shared Neighborhood Hits	54
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SF3A2_MOUSE
NC score	0.052544 (rank : 611)	θ value	θ > 10 (rank : 750)
Query Neighborhood Hits	599	Target Neighborhood Hits	247	Shared Neighborhood Hits	59
SwissProt Accessions	Q62203	Gene names	Sf3a2, Sap62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

PPIP2_HUMAN
NC score	0.052530 (rank : 612)	θ value	θ > 10 (rank : 720)
Query Neighborhood Hits	599	Target Neighborhood Hits	254	Shared Neighborhood Hits	46
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

DOCK2_MOUSE
NC score	0.052424 (rank : 613)	θ value	0.365318 (rank : 352)
Query Neighborhood Hits	599	Target Neighborhood Hits	104	Shared Neighborhood Hits	41
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

RHG18_MOUSE
NC score	0.051920 (rank : 614)	θ value	θ > 10 (rank : 741)
Query Neighborhood Hits	599	Target Neighborhood Hits	110	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

PRR8_HUMAN
NC score	0.051797 (rank : 615)	θ value	0.813845 (rank : 395)
Query Neighborhood Hits	599	Target Neighborhood Hits	217	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NSV0	Gene names	PRR8
Domain Architecture	No domain graphic available
Description	Proline-rich protein 8.

TAGAP_HUMAN
NC score	0.051546 (rank : 616)	θ value	θ > 10 (rank : 770)
Query Neighborhood Hits	599	Target Neighborhood Hits	82	Shared Neighborhood Hits	16
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

MYO9B_MOUSE
NC score	0.051247 (rank : 617)	θ value	θ > 10 (rank : 699)
Query Neighborhood Hits	599	Target Neighborhood Hits	311	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

M3K11_HUMAN
NC score	0.051219 (rank : 618)	θ value	6.88961 (rank : 542)
Query Neighborhood Hits	599	Target Neighborhood Hits	1136	Shared Neighborhood Hits	183
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

WIRE_HUMAN
NC score	0.050941 (rank : 619)	θ value	θ > 10 (rank : 790)
Query Neighborhood Hits	599	Target Neighborhood Hits	329	Shared Neighborhood Hits	82
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

CN155_HUMAN
NC score	0.050904 (rank : 620)	θ value	θ > 10 (rank : 662)
Query Neighborhood Hits	599	Target Neighborhood Hits	385	Shared Neighborhood Hits	67
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

TARA_MOUSE
NC score	0.050864 (rank : 621)	θ value	θ > 10 (rank : 772)
Query Neighborhood Hits	599	Target Neighborhood Hits	1133	Shared Neighborhood Hits	134
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

MLL2_HUMAN
NC score	0.050677 (rank : 622)	θ value	θ > 10 (rank : 693)
Query Neighborhood Hits	599	Target Neighborhood Hits	1788	Shared Neighborhood Hits	178
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

FGD2_HUMAN
NC score	0.050570 (rank : 623)	θ value	θ > 10 (rank : 675)
Query Neighborhood Hits	599	Target Neighborhood Hits	151	Shared Neighborhood Hits	34
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

PRB3_HUMAN
NC score	0.050542 (rank : 624)	θ value	θ > 10 (rank : 721)
Query Neighborhood Hits	599	Target Neighborhood Hits	318	Shared Neighborhood Hits	65
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

FGD3_MOUSE
NC score	0.050433 (rank : 625)	θ value	θ > 10 (rank : 676)
Query Neighborhood Hits	599	Target Neighborhood Hits	257	Shared Neighborhood Hits	36
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

BASP_MOUSE
NC score	0.050266 (rank : 626)	θ value	θ > 10 (rank : 641)
Query Neighborhood Hits	599	Target Neighborhood Hits	260	Shared Neighborhood Hits	45
SwissProt Accessions	Q91XV3	Gene names	Basp1, Nap22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

M3K9_HUMAN
NC score	0.049961 (rank : 627)	θ value	1.81305 (rank : 435)
Query Neighborhood Hits	599	Target Neighborhood Hits	1123	Shared Neighborhood Hits	167
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

GPS2_HUMAN
NC score	0.049553 (rank : 628)	θ value	0.62314 (rank : 375)
Query Neighborhood Hits	599	Target Neighborhood Hits	459	Shared Neighborhood Hits	61
SwissProt Accessions	Q13227	Gene names	GPS2
Domain Architecture	No domain graphic available
Description	G protein pathway suppressor 2 (Protein GPS2).

MUCDL_HUMAN
NC score	0.049057 (rank : 629)	θ value	0.47712 (rank : 365)
Query Neighborhood Hits	599	Target Neighborhood Hits	777	Shared Neighborhood Hits	91
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

SELPL_MOUSE
NC score	0.048952 (rank : 630)	θ value	0.813845 (rank : 398)
Query Neighborhood Hits	599	Target Neighborhood Hits	588	Shared Neighborhood Hits	68
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

MUC1_HUMAN
NC score	0.048211 (rank : 631)	θ value	0.0736092 (rank : 269)
Query Neighborhood Hits	599	Target Neighborhood Hits	975	Shared Neighborhood Hits	99
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

DOCK2_HUMAN
NC score	0.046436 (rank : 632)	θ value	1.38821 (rank : 419)
Query Neighborhood Hits	599	Target Neighborhood Hits	90	Shared Neighborhood Hits	46
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

MTMRD_HUMAN
NC score	0.046219 (rank : 633)	θ value	0.365318 (rank : 356)
Query Neighborhood Hits	599	Target Neighborhood Hits	135	Shared Neighborhood Hits	33
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

FGR_HUMAN
NC score	0.045976 (rank : 634)	θ value	3.0926 (rank : 474)
Query Neighborhood Hits	599	Target Neighborhood Hits	1067	Shared Neighborhood Hits	149
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

RFIP3_HUMAN
NC score	0.045943 (rank : 635)	θ value	0.0563607 (rank : 257)
Query Neighborhood Hits	599	Target Neighborhood Hits	1055	Shared Neighborhood Hits	100
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

GCC2_MOUSE
NC score	0.045808 (rank : 636)	θ value	0.0330416 (rank : 231)
Query Neighborhood Hits	599	Target Neighborhood Hits	1619	Shared Neighborhood Hits	112
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

PHLB2_MOUSE
NC score	0.045638 (rank : 637)	θ value	0.813845 (rank : 394)
Query Neighborhood Hits	599	Target Neighborhood Hits	1016	Shared Neighborhood Hits	101
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

BTK_HUMAN
NC score	0.045606 (rank : 638)	θ value	0.125558 (rank : 291)
Query Neighborhood Hits	599	Target Neighborhood Hits	1026	Shared Neighborhood Hits	154
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

PPRB_HUMAN
NC score	0.045022 (rank : 639)	θ value	0.62314 (rank : 379)
Query Neighborhood Hits	599	Target Neighborhood Hits	311	Shared Neighborhood Hits	41
SwissProt Accessions	Q15648, O43810, O75447, Q9HD39	Gene names	PPARBP, ARC205, DRIP205, TRAP220, TRIP2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2) (p53 regulatory protein RB18A) (Vitamin D receptor-interacting protein complex component DRIP205) (Activator- recruited cofactor 205 kDa component) (ARC205).

CCD41_MOUSE
NC score	0.044570 (rank : 640)	θ value	0.163984 (rank : 306)
Query Neighborhood Hits	599	Target Neighborhood Hits	1399	Shared Neighborhood Hits	107
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

MLL3_HUMAN
NC score	0.044276 (rank : 641)	θ value	2.36792 (rank : 454)
Query Neighborhood Hits	599	Target Neighborhood Hits	1644	Shared Neighborhood Hits	146
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

CBP_MOUSE
NC score	0.044256 (rank : 642)	θ value	1.06291 (rank : 402)
Query Neighborhood Hits	599	Target Neighborhood Hits	1051	Shared Neighborhood Hits	126
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

EP15R_MOUSE
NC score	0.044065 (rank : 643)	θ value	8.99809 (rank : 571)
Query Neighborhood Hits	599	Target Neighborhood Hits	1135	Shared Neighborhood Hits	101
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

SF3B1_MOUSE
NC score	0.043536 (rank : 644)	θ value	1.38821 (rank : 426)
Query Neighborhood Hits	599	Target Neighborhood Hits	352	Shared Neighborhood Hits	50
SwissProt Accessions	Q99NB9, Q9CSK5	Gene names	Sf3b1, Sap155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

FGR_MOUSE
NC score	0.043476 (rank : 645)	θ value	5.27518 (rank : 513)
Query Neighborhood Hits	599	Target Neighborhood Hits	1069	Shared Neighborhood Hits	153
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SRC_HUMAN
NC score	0.043403 (rank : 646)	θ value	6.88961 (rank : 557)
Query Neighborhood Hits	599	Target Neighborhood Hits	1058	Shared Neighborhood Hits	154
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SF3B1_HUMAN
NC score	0.043366 (rank : 647)	θ value	1.38821 (rank : 425)
Query Neighborhood Hits	599	Target Neighborhood Hits	341	Shared Neighborhood Hits	48
SwissProt Accessions	O75533	Gene names	SF3B1, SAP155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SYCP1_MOUSE
NC score	0.043111 (rank : 648)	θ value	4.03905 (rank : 503)
Query Neighborhood Hits	599	Target Neighborhood Hits	1456	Shared Neighborhood Hits	119
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

K0555_HUMAN
NC score	0.042985 (rank : 649)	θ value	1.81305 (rank : 434)
Query Neighborhood Hits	599	Target Neighborhood Hits	880	Shared Neighborhood Hits	89
SwissProt Accessions	Q96AA8, O60302	Gene names	KIAA0555
Domain Architecture	No domain graphic available
Description	Protein KIAA0555.

BTK_MOUSE
NC score	0.042929 (rank : 650)	θ value	0.47712 (rank : 361)
Query Neighborhood Hits	599	Target Neighborhood Hits	1017	Shared Neighborhood Hits	145
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

SNPC4_HUMAN
NC score	0.042818 (rank : 651)	θ value	6.88961 (rank : 556)
Query Neighborhood Hits	599	Target Neighborhood Hits	589	Shared Neighborhood Hits	79
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

TUFT1_HUMAN
NC score	0.042215 (rank : 652)	θ value	1.06291 (rank : 412)
Query Neighborhood Hits	599	Target Neighborhood Hits	686	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NNX1, Q5T384, Q5T385, Q9BU28, Q9H5L1	Gene names	TUFT1
Domain Architecture	No domain graphic available
Description	Tuftelin.

EEA1_HUMAN
NC score	0.042050 (rank : 653)	θ value	2.36792 (rank : 447)
Query Neighborhood Hits	599	Target Neighborhood Hits	1796	Shared Neighborhood Hits	130
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

MPP5_HUMAN
NC score	0.041758 (rank : 654)	θ value	1.81305 (rank : 436)
Query Neighborhood Hits	599	Target Neighborhood Hits	231	Shared Neighborhood Hits	61
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
NC score	0.041457 (rank : 655)	θ value	1.81305 (rank : 437)
Query Neighborhood Hits	599	Target Neighborhood Hits	226	Shared Neighborhood Hits	60
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

ZN385_HUMAN
NC score	0.041434 (rank : 656)	θ value	0.21417 (rank : 337)
Query Neighborhood Hits	599	Target Neighborhood Hits	614	Shared Neighborhood Hits	49
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

CP250_MOUSE
NC score	0.041117 (rank : 657)	θ value	6.88961 (rank : 537)
Query Neighborhood Hits	599	Target Neighborhood Hits	1583	Shared Neighborhood Hits	120
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

PCNT_HUMAN
NC score	0.041054 (rank : 658)	θ value	3.0926 (rank : 479)
Query Neighborhood Hits	599	Target Neighborhood Hits	1551	Shared Neighborhood Hits	127
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

RBP24_HUMAN
NC score	0.040962 (rank : 659)	θ value	2.36792 (rank : 456)
Query Neighborhood Hits	599	Target Neighborhood Hits	1559	Shared Neighborhood Hits	118
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

GCC2_HUMAN
NC score	0.040887 (rank : 660)	θ value	2.36792 (rank : 450)
Query Neighborhood Hits	599	Target Neighborhood Hits	1558	Shared Neighborhood Hits	118
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

RASA1_HUMAN
NC score	0.040864 (rank : 661)	θ value	6.88961 (rank : 553)
Query Neighborhood Hits	599	Target Neighborhood Hits	258	Shared Neighborhood Hits	57
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

CEP63_HUMAN
NC score	0.040447 (rank : 662)	θ value	3.0926 (rank : 468)
Query Neighborhood Hits	599	Target Neighborhood Hits	1005	Shared Neighborhood Hits	92
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

MPP6_MOUSE
NC score	0.040085 (rank : 663)	θ value	8.99809 (rank : 582)
Query Neighborhood Hits	599	Target Neighborhood Hits	187	Shared Neighborhood Hits	60
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

CI093_HUMAN
NC score	0.039879 (rank : 664)	θ value	1.38821 (rank : 417)
Query Neighborhood Hits	599	Target Neighborhood Hits	1088	Shared Neighborhood Hits	93
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

MYH9_MOUSE
NC score	0.039825 (rank : 665)	θ value	6.88961 (rank : 545)
Query Neighborhood Hits	599	Target Neighborhood Hits	1829	Shared Neighborhood Hits	140
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

K1802_MOUSE
NC score	0.039643 (rank : 666)	θ value	0.0736092 (rank : 268)
Query Neighborhood Hits	599	Target Neighborhood Hits	1596	Shared Neighborhood Hits	121
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MPP6_HUMAN
NC score	0.039456 (rank : 667)	θ value	8.99809 (rank : 581)
Query Neighborhood Hits	599	Target Neighborhood Hits	180	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MYO15_MOUSE
NC score	0.039117 (rank : 668)	θ value	0.279714 (rank : 342)
Query Neighborhood Hits	599	Target Neighborhood Hits	467	Shared Neighborhood Hits	84
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

MYH9_HUMAN
NC score	0.039102 (rank : 669)	θ value	6.88961 (rank : 544)
Query Neighborhood Hits	599	Target Neighborhood Hits	1762	Shared Neighborhood Hits	134
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

K1543_HUMAN
NC score	0.039070 (rank : 670)	θ value	2.36792 (rank : 452)
Query Neighborhood Hits	599	Target Neighborhood Hits	435	Shared Neighborhood Hits	51
SwissProt Accessions	Q9P1Y5, Q8NDF1	Gene names	KIAA1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

HCK_MOUSE
NC score	0.038778 (rank : 671)	θ value	0.279714 (rank : 341)
Query Neighborhood Hits	599	Target Neighborhood Hits	1029	Shared Neighborhood Hits	150
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

CR034_HUMAN
NC score	0.038549 (rank : 672)	θ value	0.813845 (rank : 391)
Query Neighborhood Hits	599	Target Neighborhood Hits	538	Shared Neighborhood Hits	65
SwissProt Accessions	Q5BJE1, Q6ZP67, Q6ZU20	Gene names	C18orf34
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34.

IWS1_HUMAN
NC score	0.038329 (rank : 673)	θ value	0.0736092 (rank : 267)
Query Neighborhood Hits	599	Target Neighborhood Hits	1241	Shared Neighborhood Hits	100
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

CEL_HUMAN
NC score	0.038201 (rank : 674)	θ value	0.0736092 (rank : 264)
Query Neighborhood Hits	599	Target Neighborhood Hits	896	Shared Neighborhood Hits	82
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

RTP3_MOUSE
NC score	0.037939 (rank : 675)	θ value	6.88961 (rank : 555)
Query Neighborhood Hits	599	Target Neighborhood Hits	374	Shared Neighborhood Hits	58
SwissProt Accessions	Q5QGU6, Q8VDC2	Gene names	Rtp3, Tmem7
Domain Architecture	No domain graphic available
Description	Receptor-transporting protein 3 (Transmembrane protein 7).

K0310_HUMAN
NC score	0.037893 (rank : 676)	θ value	8.99809 (rank : 577)
Query Neighborhood Hits	599	Target Neighborhood Hits	420	Shared Neighborhood Hits	66
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

TRIPB_HUMAN
NC score	0.037730 (rank : 677)	θ value	6.88961 (rank : 559)
Query Neighborhood Hits	599	Target Neighborhood Hits	1587	Shared Neighborhood Hits	119
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

CIC_HUMAN
NC score	0.037640 (rank : 678)	θ value	2.36792 (rank : 446)
Query Neighborhood Hits	599	Target Neighborhood Hits	992	Shared Neighborhood Hits	116
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

FA47B_HUMAN
NC score	0.037558 (rank : 679)	θ value	8.99809 (rank : 575)
Query Neighborhood Hits	599	Target Neighborhood Hits	431	Shared Neighborhood Hits	51
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

HCK_HUMAN
NC score	0.037486 (rank : 680)	θ value	5.27518 (rank : 517)
Query Neighborhood Hits	599	Target Neighborhood Hits	1035	Shared Neighborhood Hits	150
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

MAP4_HUMAN
NC score	0.037466 (rank : 681)	θ value	3.0926 (rank : 477)
Query Neighborhood Hits	599	Target Neighborhood Hits	428	Shared Neighborhood Hits	58
SwissProt Accessions	P27816, Q13082, Q96A76	Gene names	MAP4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

GOGA5_MOUSE
NC score	0.037243 (rank : 682)	θ value	5.27518 (rank : 515)
Query Neighborhood Hits	599	Target Neighborhood Hits	1434	Shared Neighborhood Hits	112
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

CUTL1_HUMAN
NC score	0.036881 (rank : 683)	θ value	0.21417 (rank : 319)
Query Neighborhood Hits	599	Target Neighborhood Hits	1574	Shared Neighborhood Hits	134
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

TENS4_MOUSE
NC score	0.036861 (rank : 684)	θ value	3.0926 (rank : 485)
Query Neighborhood Hits	599	Target Neighborhood Hits	225	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

MYO15_HUMAN
NC score	0.036834 (rank : 685)	θ value	1.06291 (rank : 406)
Query Neighborhood Hits	599	Target Neighborhood Hits	671	Shared Neighborhood Hits	87
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

TULP4_HUMAN
NC score	0.036602 (rank : 686)	θ value	0.125558 (rank : 302)
Query Neighborhood Hits	599	Target Neighborhood Hits	426	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NRJ4, Q9HD22, Q9P2F0	Gene names	TULP4, KIAA1397, TUSP
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

NFH_MOUSE
NC score	0.036408 (rank : 687)	θ value	0.279714 (rank : 343)
Query Neighborhood Hits	599	Target Neighborhood Hits	2247	Shared Neighborhood Hits	171
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

MILK1_MOUSE
NC score	0.036247 (rank : 688)	θ value	5.27518 (rank : 520)
Query Neighborhood Hits	599	Target Neighborhood Hits	788	Shared Neighborhood Hits	100
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

BAG3_MOUSE
NC score	0.036082 (rank : 689)	θ value	1.81305 (rank : 431)
Query Neighborhood Hits	599	Target Neighborhood Hits	513	Shared Neighborhood Hits	70
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

GOGA5_HUMAN
NC score	0.035858 (rank : 690)	θ value	2.36792 (rank : 451)
Query Neighborhood Hits	599	Target Neighborhood Hits	1168	Shared Neighborhood Hits	92
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

SM1L2_HUMAN
NC score	0.035379 (rank : 691)	θ value	1.81305 (rank : 441)
Query Neighborhood Hits	599	Target Neighborhood Hits	1019	Shared Neighborhood Hits	87
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

CRTC1_HUMAN
NC score	0.035198 (rank : 692)	θ value	5.27518 (rank : 510)
Query Neighborhood Hits	599	Target Neighborhood Hits	319	Shared Neighborhood Hits	63
SwissProt Accessions	Q6UUV9, O75114, Q6Y3A3, Q7LDZ2, Q8IUL3, Q8IZ34, Q8IZL1, Q8N6W3, Q96AI8, Q9H801	Gene names	CRTC1, KIAA0616, MECT1, TORC1, WAMTP1
Domain Architecture	No domain graphic available
Description	CREB-regulated transcription coactivator 1 (Transducer of regulated cAMP response element-binding protein 1) (Transducer of CREB protein 1) (Mucoepidermoid carcinoma translocated protein 1).

LARP4_MOUSE
NC score	0.035187 (rank : 693)	θ value	0.62314 (rank : 377)
Query Neighborhood Hits	599	Target Neighborhood Hits	260	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BWW4, Q3UR69	Gene names	Larp4
Domain Architecture	No domain graphic available
Description	La-related protein 4 (La ribonucleoprotein domain family member 4).

CP250_HUMAN
NC score	0.034965 (rank : 694)	θ value	8.99809 (rank : 568)
Query Neighborhood Hits	599	Target Neighborhood Hits	1805	Shared Neighborhood Hits	121
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

SEPT9_HUMAN
NC score	0.034643 (rank : 695)	θ value	0.0736092 (rank : 271)
Query Neighborhood Hits	599	Target Neighborhood Hits	706	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

MINT_MOUSE
NC score	0.034599 (rank : 696)	θ value	8.99809 (rank : 580)
Query Neighborhood Hits	599	Target Neighborhood Hits	1514	Shared Neighborhood Hits	130
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

GOGA3_MOUSE
NC score	0.034534 (rank : 697)	θ value	4.03905 (rank : 494)
Query Neighborhood Hits	599	Target Neighborhood Hits	1437	Shared Neighborhood Hits	104
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

RGS3_HUMAN
NC score	0.034504 (rank : 698)	θ value	8.99809 (rank : 590)
Query Neighborhood Hits	599	Target Neighborhood Hits	1375	Shared Neighborhood Hits	106
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

CENPE_HUMAN
NC score	0.034379 (rank : 699)	θ value	2.36792 (rank : 445)
Query Neighborhood Hits	599	Target Neighborhood Hits	2060	Shared Neighborhood Hits	136
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

GOGA3_HUMAN
NC score	0.033400 (rank : 700)	θ value	8.99809 (rank : 576)
Query Neighborhood Hits	599	Target Neighborhood Hits	1317	Shared Neighborhood Hits	105
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

MTMR5_HUMAN
NC score	0.033312 (rank : 701)	θ value	4.03905 (rank : 498)
Query Neighborhood Hits	599	Target Neighborhood Hits	141	Shared Neighborhood Hits	26
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

MUC5B_HUMAN
NC score	0.032545 (rank : 702)	θ value	6.88961 (rank : 543)
Query Neighborhood Hits	599	Target Neighborhood Hits	1020	Shared Neighborhood Hits	78
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

R3HD2_MOUSE
NC score	0.032362 (rank : 703)	θ value	2.36792 (rank : 455)
Query Neighborhood Hits	599	Target Neighborhood Hits	397	Shared Neighborhood Hits	47
SwissProt Accessions	Q80TM6, Q80YB1, Q8BLS5, Q9CW50	Gene names	R3hdm2, Kiaa1002
Domain Architecture
Description	R3H domain-containing protein 2.

AFF1_HUMAN
NC score	0.032117 (rank : 704)	θ value	6.88961 (rank : 528)
Query Neighborhood Hits	599	Target Neighborhood Hits	506	Shared Neighborhood Hits	68
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

K1802_HUMAN
NC score	0.032109 (rank : 705)	θ value	4.03905 (rank : 496)
Query Neighborhood Hits	599	Target Neighborhood Hits	1378	Shared Neighborhood Hits	112
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

SDPR_MOUSE
NC score	0.031836 (rank : 706)	θ value	0.813845 (rank : 397)
Query Neighborhood Hits	599	Target Neighborhood Hits	485	Shared Neighborhood Hits	46
SwissProt Accessions	Q63918, Q3V1P6, Q78EC3, Q8CBT4	Gene names	Sdpr, Sdr
Domain Architecture	No domain graphic available
Description	Serum deprivation-response protein (Phosphatidylserine-binding protein).

PTK6_MOUSE
NC score	0.030979 (rank : 707)	θ value	5.27518 (rank : 525)
Query Neighborhood Hits	599	Target Neighborhood Hits	1026	Shared Neighborhood Hits	131
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

TEC_MOUSE
NC score	0.030368 (rank : 708)	θ value	1.06291 (rank : 411)
Query Neighborhood Hits	599	Target Neighborhood Hits	1006	Shared Neighborhood Hits	130
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

RENT2_HUMAN
NC score	0.030005 (rank : 709)	θ value	8.99809 (rank : 589)
Query Neighborhood Hits	599	Target Neighborhood Hits	618	Shared Neighborhood Hits	64
SwissProt Accessions	Q9HAU5, Q8N8U1, Q9H1J2, Q9NWL1, Q9P2D9, Q9Y4M9	Gene names	UPF2, KIAA1408, RENT2
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 2 (Nonsense mRNA reducing factor 2) (Up-frameshift suppressor 2 homolog) (hUpf2).

SPTB2_MOUSE
NC score	0.029971 (rank : 710)	θ value	0.813845 (rank : 399)
Query Neighborhood Hits	599	Target Neighborhood Hits	770	Shared Neighborhood Hits	83
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

MTSS1_MOUSE
NC score	0.029945 (rank : 711)	θ value	8.99809 (rank : 584)
Query Neighborhood Hits	599	Target Neighborhood Hits	592	Shared Neighborhood Hits	74
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

DMD_HUMAN
NC score	0.029880 (rank : 712)	θ value	3.0926 (rank : 470)
Query Neighborhood Hits	599	Target Neighborhood Hits	1135	Shared Neighborhood Hits	97
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

CASP_HUMAN
NC score	0.029590 (rank : 713)	θ value	6.88961 (rank : 535)
Query Neighborhood Hits	599	Target Neighborhood Hits	1131	Shared Neighborhood Hits	97
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

PTK6_HUMAN
NC score	0.029154 (rank : 714)	θ value	4.03905 (rank : 501)
Query Neighborhood Hits	599	Target Neighborhood Hits	1020	Shared Neighborhood Hits	133
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

TEC_HUMAN
NC score	0.029131 (rank : 715)	θ value	3.0926 (rank : 484)
Query Neighborhood Hits	599	Target Neighborhood Hits	1006	Shared Neighborhood Hits	126
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ZIMP7_MOUSE
NC score	0.028938 (rank : 716)	θ value	1.81305 (rank : 442)
Query Neighborhood Hits	599	Target Neighborhood Hits	566	Shared Neighborhood Hits	61
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

AKAP2_MOUSE
NC score	0.028568 (rank : 717)	θ value	4.03905 (rank : 486)
Query Neighborhood Hits	599	Target Neighborhood Hits	385	Shared Neighborhood Hits	54
SwissProt Accessions	O54931, O54932, O54933	Gene names	Akap2
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2) (AKAP expressed in kidney and lung) (AKAP-KL).

EXOC8_HUMAN
NC score	0.028020 (rank : 718)	θ value	2.36792 (rank : 449)
Query Neighborhood Hits	599	Target Neighborhood Hits	46	Shared Neighborhood Hits	10
SwissProt Accessions	Q8IYI6, Q5TE82	Gene names	EXOC8
Domain Architecture	No domain graphic available
Description	Exocyst complex component 8 (Exocyst complex 84 kDa subunit).

MAML1_HUMAN
NC score	0.027602 (rank : 719)	θ value	2.36792 (rank : 453)
Query Neighborhood Hits	599	Target Neighborhood Hits	228	Shared Neighborhood Hits	34
SwissProt Accessions	Q92585, Q9NZ12	Gene names	MAML1, KIAA0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

PSL1_HUMAN
NC score	0.027553 (rank : 720)	θ value	4.03905 (rank : 500)
Query Neighborhood Hits	599	Target Neighborhood Hits	650	Shared Neighborhood Hits	66
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

HLF_HUMAN
NC score	0.027421 (rank : 721)	θ value	0.365318 (rank : 354)
Query Neighborhood Hits	599	Target Neighborhood Hits	75	Shared Neighborhood Hits	16
SwissProt Accessions	Q16534	Gene names	HLF
Domain Architecture
Description	Hepatic leukemia factor.

BAZ2A_MOUSE
NC score	0.027344 (rank : 722)	θ value	3.0926 (rank : 466)
Query Neighborhood Hits	599	Target Neighborhood Hits	744	Shared Neighborhood Hits	86
SwissProt Accessions	Q91YE5	Gene names	Baz2a, Tip5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5).

PER3_HUMAN
NC score	0.026682 (rank : 723)	θ value	1.81305 (rank : 439)
Query Neighborhood Hits	599	Target Neighborhood Hits	479	Shared Neighborhood Hits	55
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

CF182_MOUSE
NC score	0.026551 (rank : 724)	θ value	3.0926 (rank : 469)
Query Neighborhood Hits	599	Target Neighborhood Hits	551	Shared Neighborhood Hits	56
SwissProt Accessions	Q8VDS7, Q9CZE0, Q9D5A1	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf182 homolog.

HLF_MOUSE
NC score	0.026377 (rank : 725)	θ value	0.813845 (rank : 392)
Query Neighborhood Hits	599	Target Neighborhood Hits	74	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BW74, Q6PF83	Gene names	Hlf
Domain Architecture	No domain graphic available
Description	Hepatic leukemia factor.

EXOC8_MOUSE
NC score	0.026105 (rank : 726)	θ value	3.0926 (rank : 471)
Query Neighborhood Hits	599	Target Neighborhood Hits	43	Shared Neighborhood Hits	11
SwissProt Accessions	Q6PGF7	Gene names	Exoc8
Domain Architecture	No domain graphic available
Description	Exocyst complex component 8 (Exocyst complex 84 kDa subunit).

SPTB2_HUMAN
NC score	0.025732 (rank : 727)	θ value	2.36792 (rank : 459)
Query Neighborhood Hits	599	Target Neighborhood Hits	748	Shared Neighborhood Hits	78
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SETBP_HUMAN
NC score	0.025145 (rank : 728)	θ value	1.38821 (rank : 424)
Query Neighborhood Hits	599	Target Neighborhood Hits	305	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y6X0, Q9UEF3	Gene names	SETBP1, KIAA0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

ICA69_HUMAN
NC score	0.025128 (rank : 729)	θ value	0.21417 (rank : 324)
Query Neighborhood Hits	599	Target Neighborhood Hits	35	Shared Neighborhood Hits	5
SwissProt Accessions	Q05084, P78506, Q13824	Gene names	ICA1
Domain Architecture
Description	Islet cell autoantigen 1 (69 kDa islet cell autoantigen) (ICA69) (p69) (Islet cell autoantigen p69) (ICAp69).

AL2S4_MOUSE
NC score	0.024339 (rank : 730)	θ value	1.81305 (rank : 428)
Query Neighborhood Hits	599	Target Neighborhood Hits	193	Shared Neighborhood Hits	26
SwissProt Accessions	Q3V0J1, Q3TIS2	Gene names	Als2cr4
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog.

KIF5C_MOUSE
NC score	0.024147 (rank : 731)	θ value	6.88961 (rank : 540)
Query Neighborhood Hits	599	Target Neighborhood Hits	1040	Shared Neighborhood Hits	93
SwissProt Accessions	P28738, Q9Z2F8	Gene names	Kif5c, Nkhc2
Domain Architecture
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

NEMO_HUMAN
NC score	0.024009 (rank : 732)	θ value	6.88961 (rank : 546)
Query Neighborhood Hits	599	Target Neighborhood Hits	820	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y6K9	Gene names	IKBKG, FIP3, NEMO
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (FIP-3).

DLG2_MOUSE
NC score	0.023910 (rank : 733)	θ value	4.03905 (rank : 493)
Query Neighborhood Hits	599	Target Neighborhood Hits	271	Shared Neighborhood Hits	63
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

KIF5C_HUMAN
NC score	0.023791 (rank : 734)	θ value	5.27518 (rank : 518)
Query Neighborhood Hits	599	Target Neighborhood Hits	974	Shared Neighborhood Hits	88
SwissProt Accessions	O60282, O95079	Gene names	KIF5C, KIAA0531, NKHC2
Domain Architecture	No domain graphic available
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

MTSS1_HUMAN
NC score	0.023172 (rank : 735)	θ value	8.99809 (rank : 583)
Query Neighborhood Hits	599	Target Neighborhood Hits	504	Shared Neighborhood Hits	69
SwissProt Accessions	O43312, Q8TCA2, Q96RX2	Gene names	MTSS1, KIAA0429, MIM
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein) (Metastasis suppressor YGL-1).

EPAS1_MOUSE
NC score	0.021747 (rank : 736)	θ value	0.0148317 (rank : 207)
Query Neighborhood Hits	599	Target Neighborhood Hits	94	Shared Neighborhood Hits	12
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

AFF4_MOUSE
NC score	0.020510 (rank : 737)	θ value	6.88961 (rank : 529)
Query Neighborhood Hits	599	Target Neighborhood Hits	581	Shared Neighborhood Hits	47
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

OBF1_HUMAN
NC score	0.019838 (rank : 738)	θ value	5.27518 (rank : 523)
Query Neighborhood Hits	599	Target Neighborhood Hits	203	Shared Neighborhood Hits	28
SwissProt Accessions	Q16633, Q14983	Gene names	POU2AF1, OBF1
Domain Architecture	No domain graphic available
Description	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B).

MAP2_HUMAN
NC score	0.019161 (rank : 739)	θ value	8.99809 (rank : 579)
Query Neighborhood Hits	599	Target Neighborhood Hits	348	Shared Neighborhood Hits	42
SwissProt Accessions	P11137, Q99975, Q99976	Gene names	MAP2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2) (MAP-2).

MEF2B_HUMAN
NC score	0.018630 (rank : 740)	θ value	4.03905 (rank : 497)
Query Neighborhood Hits	599	Target Neighborhood Hits	150	Shared Neighborhood Hits	24
SwissProt Accessions	Q02080	Gene names	MEF2B, XMEF2
Domain Architecture
Description	Myocyte-specific enhancer factor 2B (Serum response factor-like protein 2) (XMEF2) (RSRFR2).

CD248_MOUSE
NC score	0.018047 (rank : 741)	θ value	4.03905 (rank : 491)
Query Neighborhood Hits	599	Target Neighborhood Hits	578	Shared Neighborhood Hits	51
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

EPN3_MOUSE
NC score	0.018003 (rank : 742)	θ value	8.99809 (rank : 572)
Query Neighborhood Hits	599	Target Neighborhood Hits	312	Shared Neighborhood Hits	44
SwissProt Accessions	Q91W69, Q9CV55	Gene names	Epn3
Domain Architecture
Description	Epsin-3 (EPS-15-interacting protein 3).

S25BP_MOUSE
NC score	0.017422 (rank : 743)	θ value	8.99809 (rank : 593)
Query Neighborhood Hits	599	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z266, Q3U8V4, Q922V7	Gene names	Snapap, Snap25bp
Domain Architecture	No domain graphic available
Description	SNARE-associated protein Snapin (Synaptosomal-associated protein 25- binding protein) (SNAP-associated protein).

S25BP_HUMAN
NC score	0.017416 (rank : 744)	θ value	8.99809 (rank : 592)
Query Neighborhood Hits	599	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	O95295	Gene names	SNAPAP, SNAP25BP
Domain Architecture	No domain graphic available
Description	SNARE-associated protein Snapin (Synaptosomal-associated protein 25- binding protein) (SNAP-associated protein).

TAF6L_MOUSE
NC score	0.017289 (rank : 745)	θ value	6.88961 (rank : 558)
Query Neighborhood Hits	599	Target Neighborhood Hits	146	Shared Neighborhood Hits	22
SwissProt Accessions	Q8R2K4, Q8C5T2	Gene names	Taf6l, Paf65a
Domain Architecture
Description	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (PCAF-associated factor 65 alpha) (PAF65- alpha).

NRX2B_HUMAN
NC score	0.016546 (rank : 746)	θ value	6.88961 (rank : 549)
Query Neighborhood Hits	599	Target Neighborhood Hits	481	Shared Neighborhood Hits	45
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

RECQ5_HUMAN
NC score	0.015349 (rank : 747)	θ value	3.0926 (rank : 481)
Query Neighborhood Hits	599	Target Neighborhood Hits	390	Shared Neighborhood Hits	38
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

ATF6B_HUMAN
NC score	0.014250 (rank : 748)	θ value	4.03905 (rank : 487)
Query Neighborhood Hits	599	Target Neighborhood Hits	122	Shared Neighborhood Hits	22
SwissProt Accessions	Q99941, Q13269, Q14343, Q14345, Q99635, Q99637, Q9H3V9, Q9H3W1, Q9NPL0	Gene names	CREBL1, G13
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-6 beta (Activating transcription factor 6 beta) (ATF6-beta) (cAMP-responsive element- binding protein-like 1) (cAMP response element-binding protein-related protein) (Creb-rp) (Protein G13).

NRX2A_HUMAN
NC score	0.014212 (rank : 749)	θ value	6.88961 (rank : 548)
Query Neighborhood Hits	599	Target Neighborhood Hits	614	Shared Neighborhood Hits	51
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

SFR14_MOUSE
NC score	0.012919 (rank : 750)	θ value	2.36792 (rank : 457)
Query Neighborhood Hits	599	Target Neighborhood Hits	238	Shared Neighborhood Hits	16
SwissProt Accessions	Q8CH09, Q6PG19, Q80UY8, Q8BY32, Q8CFM0	Gene names	Sfrs14
Domain Architecture	No domain graphic available
Description	Putative splicing factor, arginine/serine-rich 14 (Arginine/serine- rich-splicing factor 14).

DZIP3_MOUSE
NC score	0.011791 (rank : 751)	θ value	8.99809 (rank : 570)
Query Neighborhood Hits	599	Target Neighborhood Hits	414	Shared Neighborhood Hits	42
SwissProt Accessions	Q7TPV2, Q80TU4, Q8BYK7	Gene names	Dzip3, Kiaa0675
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3 homolog).

PHF8_HUMAN
NC score	0.011691 (rank : 752)	θ value	1.81305 (rank : 440)
Query Neighborhood Hits	599	Target Neighborhood Hits	105	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UPP1, Q5H9U5, Q5VUJ4, Q7Z6D4, Q9HAH2	Gene names	PHF8, KIAA1111, ZNF422
Domain Architecture	No domain graphic available
Description	PHD finger protein 8.

KSR1_HUMAN
NC score	0.011358 (rank : 753)	θ value	0.365318 (rank : 355)
Query Neighborhood Hits	599	Target Neighborhood Hits	867	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

MAST4_HUMAN
NC score	0.010287 (rank : 754)	θ value	0.47712 (rank : 364)
Query Neighborhood Hits	599	Target Neighborhood Hits	1804	Shared Neighborhood Hits	120
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

PO6F1_MOUSE
NC score	0.010017 (rank : 755)	θ value	0.365318 (rank : 357)
Query Neighborhood Hits	599	Target Neighborhood Hits	581	Shared Neighborhood Hits	39
SwissProt Accessions	Q07916, Q91XK3	Gene names	Pou6f1, Emb
Domain Architecture
Description	POU domain, class 6, transcription factor 1 (Octamer-binding transcription factor EMB) (Transcription regulatory protein MCP-1).

TTC16_MOUSE
NC score	0.009259 (rank : 756)	θ value	6.88961 (rank : 560)
Query Neighborhood Hits	599	Target Neighborhood Hits	98	Shared Neighborhood Hits	7
SwissProt Accessions	Q8C1F5	Gene names	Ttc16
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 16 (TPR repeat protein 16).

SMAL1_HUMAN
NC score	0.009182 (rank : 757)	θ value	2.36792 (rank : 458)
Query Neighborhood Hits	599	Target Neighborhood Hits	174	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NZC9, Q96AY1, Q9NXQ5, Q9UFH3, Q9UI93	Gene names	SMARCAL1, HARP
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (hHARP).

ADA12_MOUSE
NC score	0.008064 (rank : 758)	θ value	3.0926 (rank : 462)
Query Neighborhood Hits	599	Target Neighborhood Hits	474	Shared Neighborhood Hits	48
SwissProt Accessions	Q61824	Gene names	Adam12, Mltna
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

PDLI7_HUMAN
NC score	0.008057 (rank : 759)	θ value	8.99809 (rank : 587)
Query Neighborhood Hits	599	Target Neighborhood Hits	547	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

CP26B_HUMAN
NC score	0.008036 (rank : 760)	θ value	1.06291 (rank : 403)
Query Neighborhood Hits	599	Target Neighborhood Hits	114	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NR63, Q53TW1, Q9NP41	Gene names	CYP26B1, CYP26A2, P450RAI2
Domain Architecture
Description	Cytochrome P450 26B1 (EC 1.14.-.-) (P450 26A2) (P450 retinoic acid- inactivating 2) (P450RAI-2) (Retinoic acid-metabolizing cytochrome).

GP152_HUMAN
NC score	0.007551 (rank : 761)	θ value	5.27518 (rank : 516)
Query Neighborhood Hits	599	Target Neighborhood Hits	636	Shared Neighborhood Hits	51
SwissProt Accessions	Q8TDT2, Q86SM0	Gene names	GPR152, PGR5
Domain Architecture
Description	Probable G-protein coupled receptor 152 (G-protein coupled receptor PGR5).

ZC3H6_MOUSE
NC score	0.007261 (rank : 762)	θ value	8.99809 (rank : 599)
Query Neighborhood Hits	599	Target Neighborhood Hits	239	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BYK8, Q80UK3, Q8C1H1, Q9D604	Gene names	Zc3h6, Zc3hdc6
Domain Architecture
Description	Zinc finger CCCH domain-containing protein 6.

CNCG_MOUSE
NC score	0.006764 (rank : 763)	θ value	8.99809 (rank : 567)
Query Neighborhood Hits	599	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	P61249, Q9D1Y6, Q9EP63	Gene names	Pde6h
Domain Architecture
Description	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase gamma-subunit (EC 3.1.4.17) (GMP-PDE gamma).

TITIN_HUMAN
NC score	0.006718 (rank : 764)	θ value	2.36792 (rank : 460)
Query Neighborhood Hits	599	Target Neighborhood Hits	2923	Shared Neighborhood Hits	176
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

CT194_HUMAN
NC score	0.006573 (rank : 765)	θ value	8.99809 (rank : 569)
Query Neighborhood Hits	599	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q5TEA3, Q66K86, Q6P2R9, Q9UFX9	Gene names	C20orf194
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf194.

NOS3_HUMAN
NC score	0.006517 (rank : 766)	θ value	6.88961 (rank : 547)
Query Neighborhood Hits	599	Target Neighborhood Hits	59	Shared Neighborhood Hits	15
SwissProt Accessions	P29474, Q13662, Q14251, Q14434	Gene names	NOS3
Domain Architecture
Description	Nitric-oxide synthase, endothelial (EC 1.14.13.39) (EC-NOS) (NOS type III) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS).

LAEVR_HUMAN
NC score	0.006378 (rank : 767)	θ value	5.27518 (rank : 519)
Query Neighborhood Hits	599	Target Neighborhood Hits	73	Shared Neighborhood Hits	15
SwissProt Accessions	Q6Q4G3, Q32MR1, Q4G0I9, Q4G0V2, Q86XA3, Q8NBZ2	Gene names	LVRN
Domain Architecture	No domain graphic available
Description	Laeverin (EC 3.4.-.-) (CHL2 antigen).

CAC1B_MOUSE
NC score	0.006258 (rank : 768)	θ value	8.99809 (rank : 564)
Query Neighborhood Hits	599	Target Neighborhood Hits	351	Shared Neighborhood Hits	37
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CG026_MOUSE
NC score	0.006257 (rank : 769)	θ value	8.99809 (rank : 566)
Query Neighborhood Hits	599	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BGA7, Q3T9D0, Q8BN55	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C7orf26 homolog.

PYR1_HUMAN
NC score	0.006171 (rank : 770)	θ value	4.03905 (rank : 502)
Query Neighborhood Hits	599	Target Neighborhood Hits	119	Shared Neighborhood Hits	5
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].

KNTC1_HUMAN
NC score	0.005722 (rank : 771)	θ value	8.99809 (rank : 578)
Query Neighborhood Hits	599	Target Neighborhood Hits	67	Shared Neighborhood Hits	10
SwissProt Accessions	P50748	Gene names	KNTC1, KIAA0166
Domain Architecture	No domain graphic available
Description	Kinetochore-associated protein 1 (Rough deal homolog) (hRod) (HsROD) (Rod).

NOS3_MOUSE
NC score	0.005373 (rank : 772)	θ value	8.99809 (rank : 585)
Query Neighborhood Hits	599	Target Neighborhood Hits	63	Shared Neighborhood Hits	12
SwissProt Accessions	P70313, O55056	Gene names	Nos3, Ecnos
Domain Architecture
Description	Nitric-oxide synthase, endothelial (EC 1.14.13.39) (EC-NOS) (NOS type III) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS).

RBM4_MOUSE
NC score	0.005137 (rank : 773)	θ value	6.88961 (rank : 554)
Query Neighborhood Hits	599	Target Neighborhood Hits	223	Shared Neighborhood Hits	5
SwissProt Accessions	Q8C7Q4, O08752, Q8BN66	Gene names	Rbm4, Rbm4a
Domain Architecture	No domain graphic available
Description	RNA-binding protein 4 (RNA-binding motif protein 4) (RNA-binding motif protein 4a) (Lark homolog) (mLark).

MYLK_MOUSE
NC score	0.004835 (rank : 774)	θ value	5.27518 (rank : 521)
Query Neighborhood Hits	599	Target Neighborhood Hits	1489	Shared Neighborhood Hits	80
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

FOXK2_HUMAN
NC score	0.004323 (rank : 775)	θ value	3.0926 (rank : 475)
Query Neighborhood Hits	599	Target Neighborhood Hits	190	Shared Neighborhood Hits	16
SwissProt Accessions	Q01167, Q13622, Q13623, Q13624	Gene names	FOXK2, ILF, ILF1
Domain Architecture
Description	Forkhead box protein K2 (Interleukin enhancer-binding factor 1) (Cellular transcription factor ILF-1).

PF21A_HUMAN
NC score	0.004181 (rank : 776)	θ value	8.99809 (rank : 588)
Query Neighborhood Hits	599	Target Neighborhood Hits	303	Shared Neighborhood Hits	24
SwissProt Accessions	Q96BD5, Q6AWA2, Q9C0G7, Q9H8V9, Q9HAK6, Q9NZE9	Gene names	PHF21A, BHC80, KIAA1696
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (BHC80a).

GLTL5_HUMAN
NC score	0.003388 (rank : 777)	θ value	3.0926 (rank : 476)
Query Neighborhood Hits	599	Target Neighborhood Hits	45	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z4T8, Q75KN2, Q75MD3, Q8NCV4, Q8WW05, Q9UDR9	Gene names	GALNTL5, GALNT15
Domain Architecture	No domain graphic available
Description	Putative polypeptide N-acetylgalactosaminyltransferase-like protein 5 (EC 2.4.1.-) (Protein-UDP acetylgalactosaminyltransferase 15) (UDP- GalNAc:polypeptide N-acetylgalactosaminyltransferase 15) (Polypeptide GalNAc transferase 15) (GalNAc-T15) (pp-GaNTase 15).

EXTL1_MOUSE
NC score	0.002679 (rank : 778)	θ value	8.99809 (rank : 574)
Query Neighborhood Hits	599	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JKV7	Gene names	Extl1
Domain Architecture
Description	Exostosin-like 1 (EC 2.4.1.224) (Glucuronosyl-N-acetylglucosaminyl- proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Exostosin-L) (Multiple exostosis-like protein).

ACADV_HUMAN
NC score	0.001017 (rank : 779)	θ value	8.99809 (rank : 561)
Query Neighborhood Hits	599	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	P49748, O76056, Q8WUL0	Gene names	ACADVL, VLCAD
Domain Architecture
Description	Very-long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor (EC 1.3.99.-) (VLCAD).

ETV4_HUMAN
NC score	0.000835 (rank : 780)	θ value	8.99809 (rank : 573)
Query Neighborhood Hits	599	Target Neighborhood Hits	100	Shared Neighborhood Hits	9
SwissProt Accessions	P43268, Q96AW9	Gene names	ETV4, E1AF
Domain Architecture	No domain graphic available
Description	ETS translocation variant 4 (Adenovirus E1A enhancer-binding protein) (E1A-F).

ATS2_MOUSE
NC score	-0.001183 (rank : 781)	θ value	6.88961 (rank : 532)
Query Neighborhood Hits	599	Target Neighborhood Hits	179	Shared Neighborhood Hits	10
SwissProt Accessions	Q8C9W3	Gene names	Adamts2
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

LATS2_HUMAN
NC score	-0.001294 (rank : 782)	θ value	6.88961 (rank : 541)
Query Neighborhood Hits	599	Target Neighborhood Hits	884	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

FOG2_HUMAN
NC score	-0.001564 (rank : 783)	θ value	1.38821 (rank : 421)
Query Neighborhood Hits	599	Target Neighborhood Hits	731	Shared Neighborhood Hits	14
SwissProt Accessions	Q8WW38, Q9NPL7, Q9NPS4, Q9UNI5	Gene names	ZFPM2, FOG2
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM2 (Zinc finger protein multitype 2) (Friend of GATA protein 2) (FOG-2) (hFOG-2).

FOG2_MOUSE
NC score	-0.003239 (rank : 784)	θ value	5.27518 (rank : 514)
Query Neighborhood Hits	599	Target Neighborhood Hits	714	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CCH7, Q9Z0F2	Gene names	Zfpm2, Fog2
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM2 (Zinc finger protein multitype 2) (Friend of GATA protein 2) (Friend of GATA-2) (FOG-2) (mFOG-2).

PMYT1_MOUSE
NC score	-0.003573 (rank : 785)	θ value	5.27518 (rank : 524)
Query Neighborhood Hits	599	Target Neighborhood Hits	910	Shared Neighborhood Hits	33
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

ZN516_MOUSE
NC score	-0.003590 (rank : 786)	θ value	2.36792 (rank : 461)
Query Neighborhood Hits	599	Target Neighborhood Hits	1197	Shared Neighborhood Hits	61
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

ZN507_HUMAN
NC score	-0.008379 (rank : 787)	θ value	1.06291 (rank : 413)
Query Neighborhood Hits	599	Target Neighborhood Hits	739	Shared Neighborhood Hits	13
SwissProt Accessions	Q8TCN5	Gene names	ZNF507
Domain Architecture	No domain graphic available
Description	Zinc finger protein 507.

GLIS3_MOUSE
NC score	-0.010302 (rank : 788)	θ value	6.88961 (rank : 538)
Query Neighborhood Hits	599	Target Neighborhood Hits	861	Shared Neighborhood Hits	31
SwissProt Accessions	Q6XP49, Q8BI60	Gene names	Glis3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS3 (GLI-similar 3).

SP5_HUMAN
NC score	-0.011164 (rank : 789)	θ value	5.27518 (rank : 526)
Query Neighborhood Hits	599	Target Neighborhood Hits	832	Shared Neighborhood Hits	25
SwissProt Accessions	Q6BEB4	Gene names	SP5
Domain Architecture	No domain graphic available
Description	Transcription factor Sp5.

ZN307_HUMAN
NC score	-0.011293 (rank : 790)	θ value	5.27518 (rank : 527)
Query Neighborhood Hits	599	Target Neighborhood Hits	750	Shared Neighborhood Hits	13
SwissProt Accessions	Q969J2	Gene names	ZNF307
Domain Architecture
Description	Zinc finger protein 307 (P373c6.1).