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Network neighborhood for query Sequence : CEND2_HUMAN

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CEND2_HUMAN
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CEND1_HUMAN
θ value	0 (rank : 1)	NC score	0.944651 (rank : 5)
Query Neighborhood Hits	166	Target Neighborhood Hits	284	Shared Neighborhood Hits	133
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CEND1_MOUSE
θ value	0 (rank : 2)	NC score	0.953264 (rank : 2)
Query Neighborhood Hits	166	Target Neighborhood Hits	260	Shared Neighborhood Hits	132
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CEND2_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	166	Target Neighborhood Hits	166	Shared Neighborhood Hits	166
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

CEND3_HUMAN
θ value	0 (rank : 4)	NC score	0.947031 (rank : 4)
Query Neighborhood Hits	166	Target Neighborhood Hits	275	Shared Neighborhood Hits	112
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CEND3_MOUSE
θ value	0 (rank : 5)	NC score	0.951394 (rank : 3)
Query Neighborhood Hits	166	Target Neighborhood Hits	228	Shared Neighborhood Hits	111
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CENB5_HUMAN
θ value	3.75424e-22 (rank : 6)	NC score	0.502373 (rank : 62)
Query Neighborhood Hits	166	Target Neighborhood Hits	395	Shared Neighborhood Hits	79
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CENG1_HUMAN
θ value	1.09232e-21 (rank : 7)	NC score	0.486290 (rank : 72)
Query Neighborhood Hits	166	Target Neighborhood Hits	544	Shared Neighborhood Hits	48
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

CENG1_MOUSE
θ value	4.15078e-21 (rank : 8)	NC score	0.491558 (rank : 68)
Query Neighborhood Hits	166	Target Neighborhood Hits	531	Shared Neighborhood Hits	49
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

GRLF1_HUMAN
θ value	1.2077e-20 (rank : 9)	NC score	0.631924 (rank : 12)
Query Neighborhood Hits	166	Target Neighborhood Hits	167	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

MYO9B_MOUSE
θ value	1.5773e-20 (rank : 10)	NC score	0.346971 (rank : 86)
Query Neighborhood Hits	166	Target Neighborhood Hits	311	Shared Neighborhood Hits	62
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

MYO9B_HUMAN
θ value	3.51386e-20 (rank : 11)	NC score	0.342646 (rank : 87)
Query Neighborhood Hits	166	Target Neighborhood Hits	641	Shared Neighborhood Hits	66
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

DDEF2_HUMAN
θ value	1.33526e-19 (rank : 12)	NC score	0.485135 (rank : 73)
Query Neighborhood Hits	166	Target Neighborhood Hits	599	Shared Neighborhood Hits	67
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

CENB2_HUMAN
θ value	2.27762e-19 (rank : 13)	NC score	0.498806 (rank : 64)
Query Neighborhood Hits	166	Target Neighborhood Hits	425	Shared Neighborhood Hits	80
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

DDFL1_MOUSE
θ value	2.27762e-19 (rank : 14)	NC score	0.500263 (rank : 63)
Query Neighborhood Hits	166	Target Neighborhood Hits	324	Shared Neighborhood Hits	58
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

DDEF1_MOUSE
θ value	2.97466e-19 (rank : 15)	NC score	0.494562 (rank : 66)
Query Neighborhood Hits	166	Target Neighborhood Hits	592	Shared Neighborhood Hits	60
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_MOUSE
θ value	6.62687e-19 (rank : 16)	NC score	0.481062 (rank : 75)
Query Neighborhood Hits	166	Target Neighborhood Hits	625	Shared Neighborhood Hits	65
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

CENG3_HUMAN
θ value	1.13037e-18 (rank : 17)	NC score	0.475228 (rank : 77)
Query Neighborhood Hits	166	Target Neighborhood Hits	455	Shared Neighborhood Hits	44
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_MOUSE
θ value	1.47631e-18 (rank : 18)	NC score	0.475372 (rank : 76)
Query Neighborhood Hits	166	Target Neighborhood Hits	467	Shared Neighborhood Hits	45
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

DDFL1_HUMAN
θ value	4.29542e-18 (rank : 19)	NC score	0.524224 (rank : 56)
Query Neighborhood Hits	166	Target Neighborhood Hits	353	Shared Neighborhood Hits	61
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

RHG05_MOUSE
θ value	1.24977e-17 (rank : 20)	NC score	0.616550 (rank : 18)
Query Neighborhood Hits	166	Target Neighborhood Hits	165	Shared Neighborhood Hits	61
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG26_HUMAN
θ value	2.13179e-17 (rank : 21)	NC score	0.603843 (rank : 21)
Query Neighborhood Hits	166	Target Neighborhood Hits	281	Shared Neighborhood Hits	68
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

CENA1_HUMAN
θ value	4.74913e-17 (rank : 22)	NC score	0.576466 (rank : 31)
Query Neighborhood Hits	166	Target Neighborhood Hits	87	Shared Neighborhood Hits	64
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

BCR_HUMAN
θ value	6.20254e-17 (rank : 23)	NC score	0.570079 (rank : 37)
Query Neighborhood Hits	166	Target Neighborhood Hits	204	Shared Neighborhood Hits	71
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

SRGP2_HUMAN
θ value	8.10077e-17 (rank : 24)	NC score	0.549510 (rank : 46)
Query Neighborhood Hits	166	Target Neighborhood Hits	331	Shared Neighborhood Hits	64
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

RHG05_HUMAN
θ value	1.058e-16 (rank : 25)	NC score	0.611763 (rank : 19)
Query Neighborhood Hits	166	Target Neighborhood Hits	158	Shared Neighborhood Hits	60
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

GIT1_HUMAN
θ value	1.38178e-16 (rank : 26)	NC score	0.448786 (rank : 82)
Query Neighborhood Hits	166	Target Neighborhood Hits	336	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

GIT1_MOUSE
θ value	1.38178e-16 (rank : 27)	NC score	0.447565 (rank : 83)
Query Neighborhood Hits	166	Target Neighborhood Hits	341	Shared Neighborhood Hits	39
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

GIT2_MOUSE
θ value	1.38178e-16 (rank : 28)	NC score	0.456358 (rank : 79)
Query Neighborhood Hits	166	Target Neighborhood Hits	323	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

GMIP_MOUSE
θ value	1.80466e-16 (rank : 29)	NC score	0.640868 (rank : 8)
Query Neighborhood Hits	166	Target Neighborhood Hits	202	Shared Neighborhood Hits	64
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

CHIN_HUMAN
θ value	2.35696e-16 (rank : 30)	NC score	0.571699 (rank : 35)
Query Neighborhood Hits	166	Target Neighborhood Hits	227	Shared Neighborhood Hits	64
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CENB1_HUMAN
θ value	4.02038e-16 (rank : 31)	NC score	0.502509 (rank : 61)
Query Neighborhood Hits	166	Target Neighborhood Hits	383	Shared Neighborhood Hits	81
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

GIT2_HUMAN
θ value	4.02038e-16 (rank : 32)	NC score	0.458402 (rank : 78)
Query Neighborhood Hits	166	Target Neighborhood Hits	381	Shared Neighborhood Hits	43
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

RBP1_HUMAN
θ value	4.02038e-16 (rank : 33)	NC score	0.566510 (rank : 41)
Query Neighborhood Hits	166	Target Neighborhood Hits	521	Shared Neighborhood Hits	63
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RGAP1_MOUSE
θ value	5.25075e-16 (rank : 34)	NC score	0.634497 (rank : 11)
Query Neighborhood Hits	166	Target Neighborhood Hits	185	Shared Neighborhood Hits	59
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

CHIO_MOUSE
θ value	8.95645e-16 (rank : 35)	NC score	0.595864 (rank : 24)
Query Neighborhood Hits	166	Target Neighborhood Hits	130	Shared Neighborhood Hits	60
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

RBP1_MOUSE
θ value	8.95645e-16 (rank : 36)	NC score	0.580700 (rank : 29)
Query Neighborhood Hits	166	Target Neighborhood Hits	493	Shared Neighborhood Hits	64
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

CHIN_MOUSE
θ value	1.16975e-15 (rank : 37)	NC score	0.574141 (rank : 33)
Query Neighborhood Hits	166	Target Neighborhood Hits	229	Shared Neighborhood Hits	65
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

SMP1L_HUMAN
θ value	1.16975e-15 (rank : 38)	NC score	0.574157 (rank : 32)
Query Neighborhood Hits	166	Target Neighborhood Hits	74	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

SMP1L_MOUSE
θ value	1.16975e-15 (rank : 39)	NC score	0.573498 (rank : 34)
Query Neighborhood Hits	166	Target Neighborhood Hits	70	Shared Neighborhood Hits	38
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

CENG2_MOUSE
θ value	1.99529e-15 (rank : 40)	NC score	0.454341 (rank : 80)
Query Neighborhood Hits	166	Target Neighborhood Hits	463	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

CENG2_HUMAN
θ value	2.60593e-15 (rank : 41)	NC score	0.451921 (rank : 81)
Query Neighborhood Hits	166	Target Neighborhood Hits	471	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

CHIO_HUMAN
θ value	3.40345e-15 (rank : 42)	NC score	0.570739 (rank : 36)
Query Neighborhood Hits	166	Target Neighborhood Hits	220	Shared Neighborhood Hits	64
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

RGAP1_HUMAN
θ value	3.40345e-15 (rank : 43)	NC score	0.636313 (rank : 9)
Query Neighborhood Hits	166	Target Neighborhood Hits	189	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

SRGP2_MOUSE
θ value	3.40345e-15 (rank : 44)	NC score	0.542443 (rank : 49)
Query Neighborhood Hits	166	Target Neighborhood Hits	324	Shared Neighborhood Hits	66
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

ABR_HUMAN
θ value	5.8054e-15 (rank : 45)	NC score	0.580762 (rank : 28)
Query Neighborhood Hits	166	Target Neighborhood Hits	166	Shared Neighborhood Hits	69
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

GMIP_HUMAN
θ value	7.58209e-15 (rank : 46)	NC score	0.628173 (rank : 13)
Query Neighborhood Hits	166	Target Neighborhood Hits	225	Shared Neighborhood Hits	62
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

RHG09_HUMAN
θ value	7.58209e-15 (rank : 47)	NC score	0.660060 (rank : 6)
Query Neighborhood Hits	166	Target Neighborhood Hits	186	Shared Neighborhood Hits	65
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

RHG12_HUMAN
θ value	3.76295e-14 (rank : 48)	NC score	0.620711 (rank : 16)
Query Neighborhood Hits	166	Target Neighborhood Hits	190	Shared Neighborhood Hits	65
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	3.76295e-14 (rank : 49)	NC score	0.619976 (rank : 17)
Query Neighborhood Hits	166	Target Neighborhood Hits	204	Shared Neighborhood Hits	66
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

TCGAP_MOUSE
θ value	3.76295e-14 (rank : 50)	NC score	0.591166 (rank : 26)
Query Neighborhood Hits	166	Target Neighborhood Hits	409	Shared Neighborhood Hits	63
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SMAP1_MOUSE
θ value	1.42992e-13 (rank : 51)	NC score	0.569066 (rank : 39)
Query Neighborhood Hits	166	Target Neighborhood Hits	120	Shared Neighborhood Hits	38
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

TCGAP_HUMAN
θ value	1.42992e-13 (rank : 52)	NC score	0.533023 (rank : 54)
Query Neighborhood Hits	166	Target Neighborhood Hits	872	Shared Neighborhood Hits	71
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SMAP1_HUMAN
θ value	1.86753e-13 (rank : 53)	NC score	0.567466 (rank : 40)
Query Neighborhood Hits	166	Target Neighborhood Hits	98	Shared Neighborhood Hits	38
SwissProt Accessions	Q8IYB5, Q53H70, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4	Gene names	SMAP1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

RHG04_HUMAN
θ value	2.43908e-13 (rank : 54)	NC score	0.560614 (rank : 42)
Query Neighborhood Hits	166	Target Neighborhood Hits	307	Shared Neighborhood Hits	62
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

OPHN1_HUMAN
θ value	4.16044e-13 (rank : 55)	NC score	0.636157 (rank : 10)
Query Neighborhood Hits	166	Target Neighborhood Hits	161	Shared Neighborhood Hits	66
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

OPHN1_MOUSE
θ value	5.43371e-13 (rank : 56)	NC score	0.645277 (rank : 7)
Query Neighborhood Hits	166	Target Neighborhood Hits	174	Shared Neighborhood Hits	68
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

SRGP1_HUMAN
θ value	5.43371e-13 (rank : 57)	NC score	0.534674 (rank : 52)
Query Neighborhood Hits	166	Target Neighborhood Hits	390	Shared Neighborhood Hits	61
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

3BP1_HUMAN
θ value	7.09661e-13 (rank : 58)	NC score	0.593536 (rank : 25)
Query Neighborhood Hits	166	Target Neighborhood Hits	376	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

FNBP2_HUMAN
θ value	1.58096e-12 (rank : 59)	NC score	0.534556 (rank : 53)
Query Neighborhood Hits	166	Target Neighborhood Hits	432	Shared Neighborhood Hits	63
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

CE005_MOUSE
θ value	6.00763e-12 (rank : 60)	NC score	0.483954 (rank : 74)
Query Neighborhood Hits	166	Target Neighborhood Hits	238	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

TAGAP_HUMAN
θ value	7.84624e-12 (rank : 61)	NC score	0.569289 (rank : 38)
Query Neighborhood Hits	166	Target Neighborhood Hits	82	Shared Neighborhood Hits	57
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

RHG06_HUMAN
θ value	1.33837e-11 (rank : 62)	NC score	0.624449 (rank : 14)
Query Neighborhood Hits	166	Target Neighborhood Hits	114	Shared Neighborhood Hits	60
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG25_MOUSE
θ value	1.33837e-11 (rank : 63)	NC score	0.579467 (rank : 30)
Query Neighborhood Hits	166	Target Neighborhood Hits	492	Shared Neighborhood Hits	108
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

CE005_HUMAN
θ value	1.74796e-11 (rank : 64)	NC score	0.487037 (rank : 71)
Query Neighborhood Hits	166	Target Neighborhood Hits	213	Shared Neighborhood Hits	61
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

RHG25_HUMAN
θ value	1.74796e-11 (rank : 65)	NC score	0.542645 (rank : 48)
Query Neighborhood Hits	166	Target Neighborhood Hits	550	Shared Neighborhood Hits	109
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG06_MOUSE
θ value	2.28291e-11 (rank : 66)	NC score	0.623310 (rank : 15)
Query Neighborhood Hits	166	Target Neighborhood Hits	105	Shared Neighborhood Hits	61
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG07_MOUSE
θ value	1.133e-10 (rank : 67)	NC score	0.535061 (rank : 51)
Query Neighborhood Hits	166	Target Neighborhood Hits	103	Shared Neighborhood Hits	61
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

STA13_MOUSE
θ value	1.133e-10 (rank : 68)	NC score	0.492132 (rank : 67)
Query Neighborhood Hits	166	Target Neighborhood Hits	89	Shared Neighborhood Hits	56
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

RHG07_HUMAN
θ value	1.47974e-10 (rank : 69)	NC score	0.528939 (rank : 55)
Query Neighborhood Hits	166	Target Neighborhood Hits	108	Shared Neighborhood Hits	61
SwissProt Accessions	Q96QB1, O14868, O43199, Q9C0E0	Gene names	DLC1, ARHGAP7, KIAA1723, STARD12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

RHG08_MOUSE
θ value	1.9326e-10 (rank : 70)	NC score	0.556336 (rank : 44)
Query Neighborhood Hits	166	Target Neighborhood Hits	73	Shared Neighborhood Hits	60
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

RHG18_HUMAN
θ value	1.9326e-10 (rank : 71)	NC score	0.604772 (rank : 20)
Query Neighborhood Hits	166	Target Neighborhood Hits	90	Shared Neighborhood Hits	58
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

RHG01_HUMAN
θ value	2.52405e-10 (rank : 72)	NC score	0.583346 (rank : 27)
Query Neighborhood Hits	166	Target Neighborhood Hits	75	Shared Neighborhood Hits	60
SwissProt Accessions	Q07960	Gene names	ARHGAP1, CDC42GAP, RHOGAP1
Domain Architecture
Description	Rho-GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (CDC42 GTPase-activating protein) (p50-RhoGAP).

STA13_HUMAN
θ value	2.52405e-10 (rank : 73)	NC score	0.495949 (rank : 65)
Query Neighborhood Hits	166	Target Neighborhood Hits	89	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

3BP1_MOUSE
θ value	3.29651e-10 (rank : 74)	NC score	0.598655 (rank : 23)
Query Neighborhood Hits	166	Target Neighborhood Hits	238	Shared Neighborhood Hits	61
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

RHG18_MOUSE
θ value	3.29651e-10 (rank : 75)	NC score	0.599229 (rank : 22)
Query Neighborhood Hits	166	Target Neighborhood Hits	110	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

CENA2_MOUSE
θ value	5.62301e-10 (rank : 76)	NC score	0.536310 (rank : 50)
Query Neighborhood Hits	166	Target Neighborhood Hits	68	Shared Neighborhood Hits	57
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

STAR8_MOUSE
θ value	7.34386e-10 (rank : 77)	NC score	0.489457 (rank : 69)
Query Neighborhood Hits	166	Target Neighborhood Hits	101	Shared Neighborhood Hits	57
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

CENA2_HUMAN
θ value	9.59137e-10 (rank : 78)	NC score	0.543423 (rank : 47)
Query Neighborhood Hits	166	Target Neighborhood Hits	83	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

ARFG1_MOUSE
θ value	1.25267e-09 (rank : 79)	NC score	0.520650 (rank : 58)
Query Neighborhood Hits	166	Target Neighborhood Hits	51	Shared Neighborhood Hits	39
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

RHG08_HUMAN
θ value	1.25267e-09 (rank : 80)	NC score	0.553794 (rank : 45)
Query Neighborhood Hits	166	Target Neighborhood Hits	88	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NSG0, O75983, O95695, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NVX8, Q9NXL1, Q9UH20	Gene names	ARHGAP8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

STAR8_HUMAN
θ value	1.63604e-09 (rank : 81)	NC score	0.487303 (rank : 70)
Query Neighborhood Hits	166	Target Neighborhood Hits	216	Shared Neighborhood Hits	61
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

PKHA6_MOUSE
θ value	2.79066e-09 (rank : 82)	NC score	0.224281 (rank : 96)
Query Neighborhood Hits	166	Target Neighborhood Hits	591	Shared Neighborhood Hits	67
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

ARFG1_HUMAN
θ value	6.21693e-09 (rank : 83)	NC score	0.506234 (rank : 60)
Query Neighborhood Hits	166	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q8N6T3, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0	Gene names	ARFGAP1, ARF1GAP
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

PKHA6_HUMAN
θ value	8.11959e-09 (rank : 84)	NC score	0.221983 (rank : 97)
Query Neighborhood Hits	166	Target Neighborhood Hits	556	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

ARFG3_HUMAN
θ value	1.06045e-08 (rank : 85)	NC score	0.522236 (rank : 57)
Query Neighborhood Hits	166	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ARFG3_MOUSE
θ value	1.80886e-08 (rank : 86)	NC score	0.520514 (rank : 59)
Query Neighborhood Hits	166	Target Neighborhood Hits	80	Shared Neighborhood Hits	38
SwissProt Accessions	Q9D8S3, Q99KN8	Gene names	Arfgap3
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

TAGAP_MOUSE
θ value	5.26297e-08 (rank : 87)	NC score	0.557607 (rank : 43)
Query Neighborhood Hits	166	Target Neighborhood Hits	83	Shared Neighborhood Hits	58
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

P85A_HUMAN
θ value	3.41135e-07 (rank : 88)	NC score	0.316971 (rank : 90)
Query Neighborhood Hits	166	Target Neighborhood Hits	479	Shared Neighborhood Hits	67
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	5.81887e-07 (rank : 89)	NC score	0.311451 (rank : 92)
Query Neighborhood Hits	166	Target Neighborhood Hits	435	Shared Neighborhood Hits	67
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

PKHA1_MOUSE
θ value	1.69304e-06 (rank : 90)	NC score	0.258878 (rank : 95)
Query Neighborhood Hits	166	Target Neighborhood Hits	120	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_HUMAN
θ value	6.43352e-06 (rank : 91)	NC score	0.262595 (rank : 94)
Query Neighborhood Hits	166	Target Neighborhood Hits	127	Shared Neighborhood Hits	63
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

GAB2_MOUSE
θ value	0.000270298 (rank : 92)	NC score	0.136022 (rank : 105)
Query Neighborhood Hits	166	Target Neighborhood Hits	220	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

HRBL_MOUSE
θ value	0.00035302 (rank : 93)	NC score	0.302033 (rank : 93)
Query Neighborhood Hits	166	Target Neighborhood Hits	269	Shared Neighborhood Hits	38
SwissProt Accessions	Q80WC7, Q8BKS5, Q99J67	Gene names	Hrbl, Rabr
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

GAB2_HUMAN
θ value	0.000461057 (rank : 94)	NC score	0.132539 (rank : 107)
Query Neighborhood Hits	166	Target Neighborhood Hits	188	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

MYO10_HUMAN
θ value	0.000602161 (rank : 95)	NC score	0.091864 (rank : 125)
Query Neighborhood Hits	166	Target Neighborhood Hits	920	Shared Neighborhood Hits	73
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

HRBL_HUMAN
θ value	0.000786445 (rank : 96)	NC score	0.316931 (rank : 91)
Query Neighborhood Hits	166	Target Neighborhood Hits	179	Shared Neighborhood Hits	36
SwissProt Accessions	O95081, O75429, Q96AB9, Q96GL4	Gene names	HRBL, RABR
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

PKHA2_MOUSE
θ value	0.00390308 (rank : 97)	NC score	0.217544 (rank : 98)
Query Neighborhood Hits	166	Target Neighborhood Hits	116	Shared Neighborhood Hits	56
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

NUPL_HUMAN
θ value	0.0113563 (rank : 98)	NC score	0.357714 (rank : 84)
Query Neighborhood Hits	166	Target Neighborhood Hits	68	Shared Neighborhood Hits	36
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).

NUPL_MOUSE
θ value	0.0113563 (rank : 99)	NC score	0.354138 (rank : 85)
Query Neighborhood Hits	166	Target Neighborhood Hits	113	Shared Neighborhood Hits	36
SwissProt Accessions	Q8K2K6, O70448, Q8BQL5, Q8CDK9	Gene names	Hrb, Rip
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein homolog).

MTMRD_HUMAN
θ value	0.0193708 (rank : 100)	NC score	0.070333 (rank : 144)
Query Neighborhood Hits	166	Target Neighborhood Hits	135	Shared Neighborhood Hits	48
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

OSBP1_HUMAN
θ value	0.0252991 (rank : 101)	NC score	0.097652 (rank : 121)
Query Neighborhood Hits	166	Target Neighborhood Hits	180	Shared Neighborhood Hits	55
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

PKHA4_MOUSE
θ value	0.0330416 (rank : 102)	NC score	0.165340 (rank : 102)
Query Neighborhood Hits	166	Target Neighborhood Hits	202	Shared Neighborhood Hits	52
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

OSBP2_HUMAN
θ value	0.0431538 (rank : 103)	NC score	0.076024 (rank : 138)
Query Neighborhood Hits	166	Target Neighborhood Hits	154	Shared Neighborhood Hits	42
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

PKHA2_HUMAN
θ value	0.0431538 (rank : 104)	NC score	0.196259 (rank : 101)
Query Neighborhood Hits	166	Target Neighborhood Hits	119	Shared Neighborhood Hits	59
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHA4_HUMAN
θ value	0.0431538 (rank : 105)	NC score	0.155792 (rank : 103)
Query Neighborhood Hits	166	Target Neighborhood Hits	283	Shared Neighborhood Hits	52
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA5_HUMAN
θ value	0.0563607 (rank : 106)	NC score	0.145721 (rank : 104)
Query Neighborhood Hits	166	Target Neighborhood Hits	455	Shared Neighborhood Hits	65
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

GAB1_HUMAN
θ value	0.0736092 (rank : 107)	NC score	0.112324 (rank : 109)
Query Neighborhood Hits	166	Target Neighborhood Hits	279	Shared Neighborhood Hits	36
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

OSBP2_MOUSE
θ value	0.0736092 (rank : 108)	NC score	0.070578 (rank : 142)
Query Neighborhood Hits	166	Target Neighborhood Hits	150	Shared Neighborhood Hits	39
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

PKHA3_HUMAN
θ value	0.0961366 (rank : 109)	NC score	0.102999 (rank : 115)
Query Neighborhood Hits	166	Target Neighborhood Hits	66	Shared Neighborhood Hits	28
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

C43BP_MOUSE
θ value	0.125558 (rank : 110)	NC score	0.105615 (rank : 112)
Query Neighborhood Hits	166	Target Neighborhood Hits	91	Shared Neighborhood Hits	43
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

GAB1_MOUSE
θ value	0.125558 (rank : 111)	NC score	0.105469 (rank : 113)
Query Neighborhood Hits	166	Target Neighborhood Hits	233	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

C43BP_HUMAN
θ value	0.163984 (rank : 112)	NC score	0.099421 (rank : 119)
Query Neighborhood Hits	166	Target Neighborhood Hits	87	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

OCRL_HUMAN
θ value	0.163984 (rank : 113)	NC score	0.212646 (rank : 99)
Query Neighborhood Hits	166	Target Neighborhood Hits	77	Shared Neighborhood Hits	49
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).

PKHA3_MOUSE
θ value	0.163984 (rank : 114)	NC score	0.104522 (rank : 114)
Query Neighborhood Hits	166	Target Neighborhood Hits	67	Shared Neighborhood Hits	29
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

RASA3_HUMAN
θ value	0.163984 (rank : 115)	NC score	0.070541 (rank : 143)
Query Neighborhood Hits	166	Target Neighborhood Hits	166	Shared Neighborhood Hits	41
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

AB1IP_MOUSE
θ value	0.21417 (rank : 116)	NC score	0.055793 (rank : 169)
Query Neighborhood Hits	166	Target Neighborhood Hits	181	Shared Neighborhood Hits	17
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

AB1IP_HUMAN
θ value	0.279714 (rank : 117)	NC score	0.058461 (rank : 161)
Query Neighborhood Hits	166	Target Neighborhood Hits	213	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

MTMR5_HUMAN
θ value	0.279714 (rank : 118)	NC score	0.051477 (rank : 183)
Query Neighborhood Hits	166	Target Neighborhood Hits	141	Shared Neighborhood Hits	39
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

SWP70_HUMAN
θ value	0.365318 (rank : 119)	NC score	0.068394 (rank : 146)
Query Neighborhood Hits	166	Target Neighborhood Hits	973	Shared Neighborhood Hits	65
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
θ value	0.365318 (rank : 120)	NC score	0.067790 (rank : 147)
Query Neighborhood Hits	166	Target Neighborhood Hits	1097	Shared Neighborhood Hits	68
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

GNRP_HUMAN
θ value	0.47712 (rank : 121)	NC score	0.062489 (rank : 151)
Query Neighborhood Hits	166	Target Neighborhood Hits	239	Shared Neighborhood Hits	46
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	0.47712 (rank : 122)	NC score	0.060257 (rank : 156)
Query Neighborhood Hits	166	Target Neighborhood Hits	191	Shared Neighborhood Hits	43
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

3BP2_HUMAN
θ value	0.62314 (rank : 123)	NC score	0.098682 (rank : 120)
Query Neighborhood Hits	166	Target Neighborhood Hits	296	Shared Neighborhood Hits	45
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

CYH1_HUMAN
θ value	0.62314 (rank : 124)	NC score	0.095496 (rank : 123)
Query Neighborhood Hits	166	Target Neighborhood Hits	184	Shared Neighborhood Hits	63
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

DAPP1_HUMAN
θ value	0.62314 (rank : 125)	NC score	0.131443 (rank : 108)
Query Neighborhood Hits	166	Target Neighborhood Hits	227	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	0.62314 (rank : 126)	NC score	0.135152 (rank : 106)
Query Neighborhood Hits	166	Target Neighborhood Hits	225	Shared Neighborhood Hits	62
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

FARP2_HUMAN
θ value	0.62314 (rank : 127)	NC score	0.045568 (rank : 190)
Query Neighborhood Hits	166	Target Neighborhood Hits	240	Shared Neighborhood Hits	40
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ANLN_MOUSE
θ value	0.813845 (rank : 128)	NC score	0.043935 (rank : 191)
Query Neighborhood Hits	166	Target Neighborhood Hits	297	Shared Neighborhood Hits	20
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

CYH2_HUMAN
θ value	0.813845 (rank : 129)	NC score	0.090551 (rank : 126)
Query Neighborhood Hits	166	Target Neighborhood Hits	175	Shared Neighborhood Hits	60
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	0.813845 (rank : 130)	NC score	0.090434 (rank : 127)
Query Neighborhood Hits	166	Target Neighborhood Hits	171	Shared Neighborhood Hits	60
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

SPTN4_HUMAN
θ value	0.813845 (rank : 131)	NC score	0.018389 (rank : 204)
Query Neighborhood Hits	166	Target Neighborhood Hits	570	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

I5P2_HUMAN
θ value	1.06291 (rank : 132)	NC score	0.210254 (rank : 100)
Query Neighborhood Hits	166	Target Neighborhood Hits	86	Shared Neighborhood Hits	50
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

RASA1_HUMAN
θ value	1.06291 (rank : 133)	NC score	0.061406 (rank : 153)
Query Neighborhood Hits	166	Target Neighborhood Hits	258	Shared Neighborhood Hits	44
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

CYH1_MOUSE
θ value	1.38821 (rank : 134)	NC score	0.095282 (rank : 124)
Query Neighborhood Hits	166	Target Neighborhood Hits	176	Shared Neighborhood Hits	61
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

SOS1_HUMAN
θ value	1.38821 (rank : 135)	NC score	0.018762 (rank : 203)
Query Neighborhood Hits	166	Target Neighborhood Hits	274	Shared Neighborhood Hits	14
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

3BP2_MOUSE
θ value	1.81305 (rank : 136)	NC score	0.090210 (rank : 128)
Query Neighborhood Hits	166	Target Neighborhood Hits	142	Shared Neighborhood Hits	41
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

ANR28_HUMAN
θ value	1.81305 (rank : 137)	NC score	0.043420 (rank : 193)
Query Neighborhood Hits	166	Target Neighborhood Hits	314	Shared Neighborhood Hits	22
SwissProt Accessions	O15084, Q6ULS0, Q6ZT57	Gene names	ANKRD28, KIAA0379
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

K1914_HUMAN
θ value	1.81305 (rank : 138)	NC score	0.032167 (rank : 196)
Query Neighborhood Hits	166	Target Neighborhood Hits	255	Shared Neighborhood Hits	22
SwissProt Accessions	Q8N4X5, Q8TB54, Q96PX4, Q96SY5	Gene names	KIAA1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

ANR28_MOUSE
θ value	2.36792 (rank : 139)	NC score	0.043682 (rank : 192)
Query Neighborhood Hits	166	Target Neighborhood Hits	314	Shared Neighborhood Hits	22
SwissProt Accessions	Q505D1	Gene names	Ankrd28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

OSBL9_HUMAN
θ value	2.36792 (rank : 140)	NC score	0.076182 (rank : 137)
Query Neighborhood Hits	166	Target Neighborhood Hits	138	Shared Neighborhood Hits	49
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

RASA2_MOUSE
θ value	2.36792 (rank : 141)	NC score	0.065866 (rank : 148)
Query Neighborhood Hits	166	Target Neighborhood Hits	159	Shared Neighborhood Hits	43
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

SV2B_MOUSE
θ value	2.36792 (rank : 142)	NC score	0.006617 (rank : 208)
Query Neighborhood Hits	166	Target Neighborhood Hits	75	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BG39, Q80TT1, Q9ES95	Gene names	Sv2b, Kiaa0735
Domain Architecture	No domain graphic available
Description	Synaptic vesicle glycoprotein 2B (Synaptic vesicle protein 2B).

SYGP1_HUMAN
θ value	2.36792 (rank : 143)	NC score	0.026768 (rank : 199)
Query Neighborhood Hits	166	Target Neighborhood Hits	589	Shared Neighborhood Hits	18
SwissProt Accessions	Q96PV0, Q8TCS2, Q9UGE2	Gene names	SYNGAP1, KIAA1938
Domain Architecture
Description	Ras GTPase-activating protein SynGAP (Synaptic Ras-GTPase-activating protein 1) (Synaptic Ras-GAP 1) (Neuronal RasGAP).

TEC_MOUSE
θ value	2.36792 (rank : 144)	NC score	0.004016 (rank : 213)
Query Neighborhood Hits	166	Target Neighborhood Hits	1006	Shared Neighborhood Hits	36
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

CYH3_HUMAN
θ value	3.0926 (rank : 145)	NC score	0.087766 (rank : 129)
Query Neighborhood Hits	166	Target Neighborhood Hits	137	Shared Neighborhood Hits	56
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

CYH3_MOUSE
θ value	3.0926 (rank : 146)	NC score	0.082613 (rank : 133)
Query Neighborhood Hits	166	Target Neighborhood Hits	148	Shared Neighborhood Hits	60
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

FARP1_HUMAN
θ value	3.0926 (rank : 147)	NC score	0.053219 (rank : 176)
Query Neighborhood Hits	166	Target Neighborhood Hits	241	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

P85B_MOUSE
θ value	3.0926 (rank : 148)	NC score	0.063454 (rank : 150)
Query Neighborhood Hits	166	Target Neighborhood Hits	519	Shared Neighborhood Hits	27
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

RASA3_MOUSE
θ value	3.0926 (rank : 149)	NC score	0.058526 (rank : 160)
Query Neighborhood Hits	166	Target Neighborhood Hits	144	Shared Neighborhood Hits	38
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

ANLN_HUMAN
θ value	4.03905 (rank : 150)	NC score	0.042437 (rank : 194)
Query Neighborhood Hits	166	Target Neighborhood Hits	222	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NQW6, Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0	Gene names	ANLN
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

DAB2P_HUMAN
θ value	4.03905 (rank : 151)	NC score	0.021252 (rank : 201)
Query Neighborhood Hits	166	Target Neighborhood Hits	303	Shared Neighborhood Hits	13
SwissProt Accessions	Q5VWQ8, Q8TDL2, Q96SE1, Q9C0C0	Gene names	DAB2IP, AF9Q34, AIP1, KIAA1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein) (DAB2 interaction protein) (ASK-interacting protein 1).

DAB2P_MOUSE
θ value	4.03905 (rank : 152)	NC score	0.021055 (rank : 202)
Query Neighborhood Hits	166	Target Neighborhood Hits	284	Shared Neighborhood Hits	12
SwissProt Accessions	Q3UHC7, Q3TPD5, Q3UH44, Q6JTV1, Q80T97	Gene names	Dab2ip, Kiaa1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein).

DOCK9_HUMAN
θ value	4.03905 (rank : 153)	NC score	0.027496 (rank : 198)
Query Neighborhood Hits	166	Target Neighborhood Hits	82	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BZ29, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4	Gene names	DOCK9, KIAA1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

FGD4_MOUSE
θ value	4.03905 (rank : 154)	NC score	0.047570 (rank : 188)
Query Neighborhood Hits	166	Target Neighborhood Hits	227	Shared Neighborhood Hits	42
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

MMEL1_HUMAN
θ value	4.03905 (rank : 155)	NC score	0.004568 (rank : 211)
Query Neighborhood Hits	166	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	Q495T6, Q495T7, Q495T8, Q5SZS6, Q96PH9	Gene names	MMEL1, MELL1, MMEL2, NEP2
Domain Architecture	No domain graphic available
Description	Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (Neprilysin-2) (Neprilysin II) (NL2) (NEPII) (NEP2(m)) [Contains: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))].

FGD6_HUMAN
θ value	5.27518 (rank : 156)	NC score	0.047040 (rank : 189)
Query Neighborhood Hits	166	Target Neighborhood Hits	237	Shared Neighborhood Hits	49
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

SPG3A_MOUSE
θ value	5.27518 (rank : 157)	NC score	0.009853 (rank : 207)
Query Neighborhood Hits	166	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BH66, Q8BJH5	Gene names	Spg3a, Gbp3
Domain Architecture
Description	Atlastin (GTP-binding protein 3) (Guanine nucleotide-binding protein 3) (GBP-3).

SPTN5_HUMAN
θ value	5.27518 (rank : 158)	NC score	0.010822 (rank : 205)
Query Neighborhood Hits	166	Target Neighborhood Hits	674	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

HPS3_MOUSE
θ value	6.88961 (rank : 159)	NC score	0.010102 (rank : 206)
Query Neighborhood Hits	166	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q91VB4, Q8VDX2, Q8VHT1	Gene names	Hps3, Coa
Domain Architecture	No domain graphic available
Description	Hermansky-Pudlak syndrome 3 protein homolog (Cocoa protein).

THIM_MOUSE
θ value	6.88961 (rank : 160)	NC score	0.004117 (rank : 212)
Query Neighborhood Hits	166	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BWT1, Q8JZR8	Gene names	Acaa2
Domain Architecture	No domain graphic available
Description	3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Beta- ketothiolase) (Acetyl-CoA acyltransferase) (Mitochondrial 3-oxoacyl- CoA thiolase).

TLN1_HUMAN
θ value	6.88961 (rank : 161)	NC score	0.005641 (rank : 209)
Query Neighborhood Hits	166	Target Neighborhood Hits	218	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

TLN1_MOUSE
θ value	6.88961 (rank : 162)	NC score	0.005118 (rank : 210)
Query Neighborhood Hits	166	Target Neighborhood Hits	213	Shared Neighborhood Hits	7
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

ANR25_MOUSE
θ value	8.99809 (rank : 163)	NC score	0.021796 (rank : 200)
Query Neighborhood Hits	166	Target Neighborhood Hits	398	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BX02, Q8BLD5, Q91Z35	Gene names	Ankrd25
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25.

DGKH_HUMAN
θ value	8.99809 (rank : 164)	NC score	0.099897 (rank : 117)
Query Neighborhood Hits	166	Target Neighborhood Hits	255	Shared Neighborhood Hits	53
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

FGD4_HUMAN
θ value	8.99809 (rank : 165)	NC score	0.036948 (rank : 195)
Query Neighborhood Hits	166	Target Neighborhood Hits	219	Shared Neighborhood Hits	41
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD5_HUMAN
θ value	8.99809 (rank : 166)	NC score	0.031246 (rank : 197)
Query Neighborhood Hits	166	Target Neighborhood Hits	235	Shared Neighborhood Hits	36
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

ANR37_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.055505 (rank : 170)
Query Neighborhood Hits	166	Target Neighborhood Hits	247	Shared Neighborhood Hits	18
SwissProt Accessions	Q7Z713	Gene names	ANKRD37, LPR2BP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37 (Low-density lipoprotein receptor-related protein 2-binding protein) (hLrp2bp).

ANR37_MOUSE
θ value	θ > 10 (rank : 168)	NC score	0.064791 (rank : 149)
Query Neighborhood Hits	166	Target Neighborhood Hits	237	Shared Neighborhood Hits	19
SwissProt Accessions	Q569N2, Q8CHS0	Gene names	Ankrd37
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37.

ANR39_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.057341 (rank : 164)
Query Neighborhood Hits	166	Target Neighborhood Hits	285	Shared Neighborhood Hits	21
SwissProt Accessions	Q53RE8, Q59FU2, Q8N5X5, Q9P0S5	Gene names	ANKRD39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ANR39_MOUSE
θ value	θ > 10 (rank : 170)	NC score	0.058700 (rank : 159)
Query Neighborhood Hits	166	Target Neighborhood Hits	284	Shared Neighborhood Hits	21
SwissProt Accessions	Q9D2X0	Gene names	Ankrd39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ANR41_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.069359 (rank : 145)
Query Neighborhood Hits	166	Target Neighborhood Hits	332	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NAG6, Q8N8J8	Gene names	ANKRD41
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 41.

ANR46_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.061529 (rank : 152)
Query Neighborhood Hits	166	Target Neighborhood Hits	281	Shared Neighborhood Hits	20
SwissProt Accessions	Q86W74, Q6P9B7	Gene names	ANKRD46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

ANR46_MOUSE
θ value	θ > 10 (rank : 173)	NC score	0.060952 (rank : 154)
Query Neighborhood Hits	166	Target Neighborhood Hits	274	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BTZ5, Q1LZK9, Q8BV97	Gene names	Ankrd46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

ANS4B_HUMAN
θ value	θ > 10 (rank : 174)	NC score	0.050783 (rank : 185)
Query Neighborhood Hits	166	Target Neighborhood Hits	289	Shared Neighborhood Hits	19
SwissProt Accessions	Q8N8V4	Gene names	ANKS4B, HARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

ANS4B_MOUSE
θ value	θ > 10 (rank : 175)	NC score	0.055907 (rank : 168)
Query Neighborhood Hits	166	Target Neighborhood Hits	294	Shared Neighborhood Hits	19
SwissProt Accessions	Q8K3X6, Q9D8A5	Gene names	Anks4b, Harp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

CNKR1_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.076242 (rank : 136)
Query Neighborhood Hits	166	Target Neighborhood Hits	154	Shared Neighborhood Hits	40
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CNKR2_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.056382 (rank : 167)
Query Neighborhood Hits	166	Target Neighborhood Hits	197	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	θ > 10 (rank : 178)	NC score	0.057205 (rank : 165)
Query Neighborhood Hits	166	Target Neighborhood Hits	197	Shared Neighborhood Hits	39
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CSKI2_HUMAN
θ value	θ > 10 (rank : 179)	NC score	0.056430 (rank : 166)
Query Neighborhood Hits	166	Target Neighborhood Hits	747	Shared Neighborhood Hits	34
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CSKI2_MOUSE
θ value	θ > 10 (rank : 180)	NC score	0.057411 (rank : 163)
Query Neighborhood Hits	166	Target Neighborhood Hits	812	Shared Neighborhood Hits	36
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CT086_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.079926 (rank : 135)
Query Neighborhood Hits	166	Target Neighborhood Hits	277	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BZ19, Q4VXE6	Gene names	C20orf86
Domain Architecture
Description	Putative uncharacterized protein C20orf86.

CYH4_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.073101 (rank : 141)
Query Neighborhood Hits	166	Target Neighborhood Hits	135	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

CYH4_MOUSE
θ value	θ > 10 (rank : 183)	NC score	0.074495 (rank : 139)
Query Neighborhood Hits	166	Target Neighborhood Hits	134	Shared Neighborhood Hits	56
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

DGKD_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.073315 (rank : 140)
Query Neighborhood Hits	166	Target Neighborhood Hits	231	Shared Neighborhood Hits	35
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

DP13A_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.109989 (rank : 110)
Query Neighborhood Hits	166	Target Neighborhood Hits	107	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13A_MOUSE
θ value	θ > 10 (rank : 186)	NC score	0.106948 (rank : 111)
Query Neighborhood Hits	166	Target Neighborhood Hits	96	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K3H0, Q3UJP7, Q69ZJ9, Q8BWZ8, Q8VCJ8, Q9CUW4	Gene names	Appl1, Dip13a, Kiaa1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13B_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.095560 (rank : 122)
Query Neighborhood Hits	166	Target Neighborhood Hits	58	Shared Neighborhood Hits	18
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

DP13B_MOUSE
θ value	θ > 10 (rank : 188)	NC score	0.102341 (rank : 116)
Query Neighborhood Hits	166	Target Neighborhood Hits	58	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

FA13A_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.052673 (rank : 178)
Query Neighborhood Hits	166	Target Neighborhood Hits	102	Shared Neighborhood Hits	2
SwissProt Accessions	O94988, Q8NBA3	Gene names	FAM13A1, KIAA0914
Domain Architecture	No domain graphic available
Description	Protein FAM13A1.

FA13A_MOUSE
θ value	θ > 10 (rank : 190)	NC score	0.053527 (rank : 175)
Query Neighborhood Hits	166	Target Neighborhood Hits	83	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BGI4, Q8BZ91	Gene names	Fam13a1, Precm1
Domain Architecture	No domain graphic available
Description	Protein FAM13A1 (Precm1 protein).

GABP2_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.052548 (rank : 179)
Query Neighborhood Hits	166	Target Neighborhood Hits	454	Shared Neighborhood Hits	23
SwissProt Accessions	Q06547, Q06545, Q12940, Q12941, Q12942, Q8IYD0	Gene names	GABPB2, E4TF1B, GABPB, GABPB1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1) (Transcription factor E4TF1-53) (Transcription factor E4TF1-47) (Nuclear respiratory factor 2).

GABP2_MOUSE
θ value	θ > 10 (rank : 192)	NC score	0.052484 (rank : 180)
Query Neighborhood Hits	166	Target Neighborhood Hits	429	Shared Neighborhood Hits	23
SwissProt Accessions	Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2	Gene names	Gabpb2, Gabpb, Gabpb1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1).

GABP3_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.054634 (rank : 172)
Query Neighborhood Hits	166	Target Neighborhood Hits	330	Shared Neighborhood Hits	22
SwissProt Accessions	P81069	Gene names	Gabpb2
Domain Architecture	No domain graphic available
Description	GA-binding protein beta-2-1 chain (GABP subunit beta-2-1) (GABPB2-1).

GRP3_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.060939 (rank : 155)
Query Neighborhood Hits	166	Target Neighborhood Hits	131	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

HECD1_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.050004 (rank : 186)
Query Neighborhood Hits	166	Target Neighborhood Hits	371	Shared Neighborhood Hits	22
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

IASPP_MOUSE
θ value	θ > 10 (rank : 196)	NC score	0.054528 (rank : 173)
Query Neighborhood Hits	166	Target Neighborhood Hits	1024	Shared Neighborhood Hits	38
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IKBB_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.050808 (rank : 184)
Query Neighborhood Hits	166	Target Neighborhood Hits	284	Shared Neighborhood Hits	21
SwissProt Accessions	Q15653, Q96BJ7	Gene names	NFKBIB, IKBB, TRIP9
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9).

IKBB_MOUSE
θ value	θ > 10 (rank : 198)	NC score	0.059226 (rank : 158)
Query Neighborhood Hits	166	Target Neighborhood Hits	284	Shared Neighborhood Hits	21
SwissProt Accessions	Q60778, Q9D6L5	Gene names	Nfkbib, Ikbb
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B).

K1688_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.320336 (rank : 89)
Query Neighborhood Hits	166	Target Neighborhood Hits	217	Shared Neighborhood Hits	60
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

K1688_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.330229 (rank : 88)
Query Neighborhood Hits	166	Target Neighborhood Hits	188	Shared Neighborhood Hits	62
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

MRIP_MOUSE
θ value	θ > 10 (rank : 201)	NC score	0.053681 (rank : 174)
Query Neighborhood Hits	166	Target Neighborhood Hits	569	Shared Neighborhood Hits	50
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

MTPN_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.050002 (rank : 187)
Query Neighborhood Hits	166	Target Neighborhood Hits	269	Shared Neighborhood Hits	19
SwissProt Accessions	P62774, P80144, Q543M6, Q9DCN8	Gene names	Mtpn, Gcdp
Domain Architecture	No domain graphic available
Description	Myotrophin (Protein V-1) (Granule cell differentiation protein).

P85B_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.080346 (rank : 134)
Query Neighborhood Hits	166	Target Neighborhood Hits	543	Shared Neighborhood Hits	30
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PCTL_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.052164 (rank : 181)
Query Neighborhood Hits	166	Target Neighborhood Hits	26	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y365, O60532	Gene names	STARD10, SDCCAG28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28) (Antigen NY-CO-28).

PCTL_MOUSE
θ value	θ > 10 (rank : 205)	NC score	0.052776 (rank : 177)
Query Neighborhood Hits	166	Target Neighborhood Hits	26	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JMD3	Gene names	Stard10, Pctpl, Sdccag28, Sdccagg28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28 homolog).

PKHB2_MOUSE
θ value	θ > 10 (rank : 206)	NC score	0.051688 (rank : 182)
Query Neighborhood Hits	166	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

PLEK2_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.086385 (rank : 130)
Query Neighborhood Hits	166	Target Neighborhood Hits	101	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.082640 (rank : 132)
Query Neighborhood Hits	166	Target Neighborhood Hits	96	Shared Neighborhood Hits	53
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PLEK_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.099456 (rank : 118)
Query Neighborhood Hits	166	Target Neighborhood Hits	110	Shared Neighborhood Hits	56
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PLEK_MOUSE
θ value	θ > 10 (rank : 210)	NC score	0.085463 (rank : 131)
Query Neighborhood Hits	166	Target Neighborhood Hits	109	Shared Neighborhood Hits	53
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

RASA2_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.057826 (rank : 162)
Query Neighborhood Hits	166	Target Neighborhood Hits	157	Shared Neighborhood Hits	38
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

TNKS1_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.059783 (rank : 157)
Query Neighborhood Hits	166	Target Neighborhood Hits	477	Shared Neighborhood Hits	27
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

TNKS2_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.055303 (rank : 171)
Query Neighborhood Hits	166	Target Neighborhood Hits	361	Shared Neighborhood Hits	26
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

Hits sorted by NC score

CEND2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	166	Target Neighborhood Hits	166	Shared Neighborhood Hits	166
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

CEND1_MOUSE
NC score	0.953264 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	166	Target Neighborhood Hits	260	Shared Neighborhood Hits	132
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CEND3_MOUSE
NC score	0.951394 (rank : 3)	θ value	0 (rank : 5)
Query Neighborhood Hits	166	Target Neighborhood Hits	228	Shared Neighborhood Hits	111
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CEND3_HUMAN
NC score	0.947031 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	166	Target Neighborhood Hits	275	Shared Neighborhood Hits	112
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CEND1_HUMAN
NC score	0.944651 (rank : 5)	θ value	0 (rank : 1)
Query Neighborhood Hits	166	Target Neighborhood Hits	284	Shared Neighborhood Hits	133
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

RHG09_HUMAN
NC score	0.660060 (rank : 6)	θ value	7.58209e-15 (rank : 47)
Query Neighborhood Hits	166	Target Neighborhood Hits	186	Shared Neighborhood Hits	65
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

OPHN1_MOUSE
NC score	0.645277 (rank : 7)	θ value	5.43371e-13 (rank : 56)
Query Neighborhood Hits	166	Target Neighborhood Hits	174	Shared Neighborhood Hits	68
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

GMIP_MOUSE
NC score	0.640868 (rank : 8)	θ value	1.80466e-16 (rank : 29)
Query Neighborhood Hits	166	Target Neighborhood Hits	202	Shared Neighborhood Hits	64
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

RGAP1_HUMAN
NC score	0.636313 (rank : 9)	θ value	3.40345e-15 (rank : 43)
Query Neighborhood Hits	166	Target Neighborhood Hits	189	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

OPHN1_HUMAN
NC score	0.636157 (rank : 10)	θ value	4.16044e-13 (rank : 55)
Query Neighborhood Hits	166	Target Neighborhood Hits	161	Shared Neighborhood Hits	66
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

RGAP1_MOUSE
NC score	0.634497 (rank : 11)	θ value	5.25075e-16 (rank : 34)
Query Neighborhood Hits	166	Target Neighborhood Hits	185	Shared Neighborhood Hits	59
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

GRLF1_HUMAN
NC score	0.631924 (rank : 12)	θ value	1.2077e-20 (rank : 9)
Query Neighborhood Hits	166	Target Neighborhood Hits	167	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

GMIP_HUMAN
NC score	0.628173 (rank : 13)	θ value	7.58209e-15 (rank : 46)
Query Neighborhood Hits	166	Target Neighborhood Hits	225	Shared Neighborhood Hits	62
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

RHG06_HUMAN
NC score	0.624449 (rank : 14)	θ value	1.33837e-11 (rank : 62)
Query Neighborhood Hits	166	Target Neighborhood Hits	114	Shared Neighborhood Hits	60
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG06_MOUSE
NC score	0.623310 (rank : 15)	θ value	2.28291e-11 (rank : 66)
Query Neighborhood Hits	166	Target Neighborhood Hits	105	Shared Neighborhood Hits	61
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG12_HUMAN
NC score	0.620711 (rank : 16)	θ value	3.76295e-14 (rank : 48)
Query Neighborhood Hits	166	Target Neighborhood Hits	190	Shared Neighborhood Hits	65
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
NC score	0.619976 (rank : 17)	θ value	3.76295e-14 (rank : 49)
Query Neighborhood Hits	166	Target Neighborhood Hits	204	Shared Neighborhood Hits	66
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG05_MOUSE
NC score	0.616550 (rank : 18)	θ value	1.24977e-17 (rank : 20)
Query Neighborhood Hits	166	Target Neighborhood Hits	165	Shared Neighborhood Hits	61
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG05_HUMAN
NC score	0.611763 (rank : 19)	θ value	1.058e-16 (rank : 25)
Query Neighborhood Hits	166	Target Neighborhood Hits	158	Shared Neighborhood Hits	60
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG18_HUMAN
NC score	0.604772 (rank : 20)	θ value	1.9326e-10 (rank : 71)
Query Neighborhood Hits	166	Target Neighborhood Hits	90	Shared Neighborhood Hits	58
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

RHG26_HUMAN
NC score	0.603843 (rank : 21)	θ value	2.13179e-17 (rank : 21)
Query Neighborhood Hits	166	Target Neighborhood Hits	281	Shared Neighborhood Hits	68
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RHG18_MOUSE
NC score	0.599229 (rank : 22)	θ value	3.29651e-10 (rank : 75)
Query Neighborhood Hits	166	Target Neighborhood Hits	110	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

3BP1_MOUSE
NC score	0.598655 (rank : 23)	θ value	3.29651e-10 (rank : 74)
Query Neighborhood Hits	166	Target Neighborhood Hits	238	Shared Neighborhood Hits	61
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

CHIO_MOUSE
NC score	0.595864 (rank : 24)	θ value	8.95645e-16 (rank : 35)
Query Neighborhood Hits	166	Target Neighborhood Hits	130	Shared Neighborhood Hits	60
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

3BP1_HUMAN
NC score	0.593536 (rank : 25)	θ value	7.09661e-13 (rank : 58)
Query Neighborhood Hits	166	Target Neighborhood Hits	376	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

TCGAP_MOUSE
NC score	0.591166 (rank : 26)	θ value	3.76295e-14 (rank : 50)
Query Neighborhood Hits	166	Target Neighborhood Hits	409	Shared Neighborhood Hits	63
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

RHG01_HUMAN
NC score	0.583346 (rank : 27)	θ value	2.52405e-10 (rank : 72)
Query Neighborhood Hits	166	Target Neighborhood Hits	75	Shared Neighborhood Hits	60
SwissProt Accessions	Q07960	Gene names	ARHGAP1, CDC42GAP, RHOGAP1
Domain Architecture
Description	Rho-GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (CDC42 GTPase-activating protein) (p50-RhoGAP).

ABR_HUMAN
NC score	0.580762 (rank : 28)	θ value	5.8054e-15 (rank : 45)
Query Neighborhood Hits	166	Target Neighborhood Hits	166	Shared Neighborhood Hits	69
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

RBP1_MOUSE
NC score	0.580700 (rank : 29)	θ value	8.95645e-16 (rank : 36)
Query Neighborhood Hits	166	Target Neighborhood Hits	493	Shared Neighborhood Hits	64
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RHG25_MOUSE
NC score	0.579467 (rank : 30)	θ value	1.33837e-11 (rank : 63)
Query Neighborhood Hits	166	Target Neighborhood Hits	492	Shared Neighborhood Hits	108
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

CENA1_HUMAN
NC score	0.576466 (rank : 31)	θ value	4.74913e-17 (rank : 22)
Query Neighborhood Hits	166	Target Neighborhood Hits	87	Shared Neighborhood Hits	64
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

SMP1L_HUMAN
NC score	0.574157 (rank : 32)	θ value	1.16975e-15 (rank : 38)
Query Neighborhood Hits	166	Target Neighborhood Hits	74	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

CHIN_MOUSE
NC score	0.574141 (rank : 33)	θ value	1.16975e-15 (rank : 37)
Query Neighborhood Hits	166	Target Neighborhood Hits	229	Shared Neighborhood Hits	65
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

SMP1L_MOUSE
NC score	0.573498 (rank : 34)	θ value	1.16975e-15 (rank : 39)
Query Neighborhood Hits	166	Target Neighborhood Hits	70	Shared Neighborhood Hits	38
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

CHIN_HUMAN
NC score	0.571699 (rank : 35)	θ value	2.35696e-16 (rank : 30)
Query Neighborhood Hits	166	Target Neighborhood Hits	227	Shared Neighborhood Hits	64
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
NC score	0.570739 (rank : 36)	θ value	3.40345e-15 (rank : 42)
Query Neighborhood Hits	166	Target Neighborhood Hits	220	Shared Neighborhood Hits	64
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

BCR_HUMAN
NC score	0.570079 (rank : 37)	θ value	6.20254e-17 (rank : 23)
Query Neighborhood Hits	166	Target Neighborhood Hits	204	Shared Neighborhood Hits	71
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

TAGAP_HUMAN
NC score	0.569289 (rank : 38)	θ value	7.84624e-12 (rank : 61)
Query Neighborhood Hits	166	Target Neighborhood Hits	82	Shared Neighborhood Hits	57
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

SMAP1_MOUSE
NC score	0.569066 (rank : 39)	θ value	1.42992e-13 (rank : 51)
Query Neighborhood Hits	166	Target Neighborhood Hits	120	Shared Neighborhood Hits	38
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMAP1_HUMAN
NC score	0.567466 (rank : 40)	θ value	1.86753e-13 (rank : 53)
Query Neighborhood Hits	166	Target Neighborhood Hits	98	Shared Neighborhood Hits	38
SwissProt Accessions	Q8IYB5, Q53H70, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4	Gene names	SMAP1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

RBP1_HUMAN
NC score	0.566510 (rank : 41)	θ value	4.02038e-16 (rank : 33)
Query Neighborhood Hits	166	Target Neighborhood Hits	521	Shared Neighborhood Hits	63
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RHG04_HUMAN
NC score	0.560614 (rank : 42)	θ value	2.43908e-13 (rank : 54)
Query Neighborhood Hits	166	Target Neighborhood Hits	307	Shared Neighborhood Hits	62
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

TAGAP_MOUSE
NC score	0.557607 (rank : 43)	θ value	5.26297e-08 (rank : 87)
Query Neighborhood Hits	166	Target Neighborhood Hits	83	Shared Neighborhood Hits	58
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

RHG08_MOUSE
NC score	0.556336 (rank : 44)	θ value	1.9326e-10 (rank : 70)
Query Neighborhood Hits	166	Target Neighborhood Hits	73	Shared Neighborhood Hits	60
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

RHG08_HUMAN
NC score	0.553794 (rank : 45)	θ value	1.25267e-09 (rank : 80)
Query Neighborhood Hits	166	Target Neighborhood Hits	88	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NSG0, O75983, O95695, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NVX8, Q9NXL1, Q9UH20	Gene names	ARHGAP8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

SRGP2_HUMAN
NC score	0.549510 (rank : 46)	θ value	8.10077e-17 (rank : 24)
Query Neighborhood Hits	166	Target Neighborhood Hits	331	Shared Neighborhood Hits	64
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

CENA2_HUMAN
NC score	0.543423 (rank : 47)	θ value	9.59137e-10 (rank : 78)
Query Neighborhood Hits	166	Target Neighborhood Hits	83	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

RHG25_HUMAN
NC score	0.542645 (rank : 48)	θ value	1.74796e-11 (rank : 65)
Query Neighborhood Hits	166	Target Neighborhood Hits	550	Shared Neighborhood Hits	109
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

SRGP2_MOUSE
NC score	0.542443 (rank : 49)	θ value	3.40345e-15 (rank : 44)
Query Neighborhood Hits	166	Target Neighborhood Hits	324	Shared Neighborhood Hits	66
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

CENA2_MOUSE
NC score	0.536310 (rank : 50)	θ value	5.62301e-10 (rank : 76)
Query Neighborhood Hits	166	Target Neighborhood Hits	68	Shared Neighborhood Hits	57
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

RHG07_MOUSE
NC score	0.535061 (rank : 51)	θ value	1.133e-10 (rank : 67)
Query Neighborhood Hits	166	Target Neighborhood Hits	103	Shared Neighborhood Hits	61
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

SRGP1_HUMAN
NC score	0.534674 (rank : 52)	θ value	5.43371e-13 (rank : 57)
Query Neighborhood Hits	166	Target Neighborhood Hits	390	Shared Neighborhood Hits	61
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

FNBP2_HUMAN
NC score	0.534556 (rank : 53)	θ value	1.58096e-12 (rank : 59)
Query Neighborhood Hits	166	Target Neighborhood Hits	432	Shared Neighborhood Hits	63
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

TCGAP_HUMAN
NC score	0.533023 (rank : 54)	θ value	1.42992e-13 (rank : 52)
Query Neighborhood Hits	166	Target Neighborhood Hits	872	Shared Neighborhood Hits	71
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

RHG07_HUMAN
NC score	0.528939 (rank : 55)	θ value	1.47974e-10 (rank : 69)
Query Neighborhood Hits	166	Target Neighborhood Hits	108	Shared Neighborhood Hits	61
SwissProt Accessions	Q96QB1, O14868, O43199, Q9C0E0	Gene names	DLC1, ARHGAP7, KIAA1723, STARD12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

DDFL1_HUMAN
NC score	0.524224 (rank : 56)	θ value	4.29542e-18 (rank : 19)
Query Neighborhood Hits	166	Target Neighborhood Hits	353	Shared Neighborhood Hits	61
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

ARFG3_HUMAN
NC score	0.522236 (rank : 57)	θ value	1.06045e-08 (rank : 85)
Query Neighborhood Hits	166	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ARFG1_MOUSE
NC score	0.520650 (rank : 58)	θ value	1.25267e-09 (rank : 79)
Query Neighborhood Hits	166	Target Neighborhood Hits	51	Shared Neighborhood Hits	39
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

ARFG3_MOUSE
NC score	0.520514 (rank : 59)	θ value	1.80886e-08 (rank : 86)
Query Neighborhood Hits	166	Target Neighborhood Hits	80	Shared Neighborhood Hits	38
SwissProt Accessions	Q9D8S3, Q99KN8	Gene names	Arfgap3
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ARFG1_HUMAN
NC score	0.506234 (rank : 60)	θ value	6.21693e-09 (rank : 83)
Query Neighborhood Hits	166	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q8N6T3, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0	Gene names	ARFGAP1, ARF1GAP
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

CENB1_HUMAN
NC score	0.502509 (rank : 61)	θ value	4.02038e-16 (rank : 31)
Query Neighborhood Hits	166	Target Neighborhood Hits	383	Shared Neighborhood Hits	81
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

CENB5_HUMAN
NC score	0.502373 (rank : 62)	θ value	3.75424e-22 (rank : 6)
Query Neighborhood Hits	166	Target Neighborhood Hits	395	Shared Neighborhood Hits	79
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

DDFL1_MOUSE
NC score	0.500263 (rank : 63)	θ value	2.27762e-19 (rank : 14)
Query Neighborhood Hits	166	Target Neighborhood Hits	324	Shared Neighborhood Hits	58
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

CENB2_HUMAN
NC score	0.498806 (rank : 64)	θ value	2.27762e-19 (rank : 13)
Query Neighborhood Hits	166	Target Neighborhood Hits	425	Shared Neighborhood Hits	80
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

STA13_HUMAN
NC score	0.495949 (rank : 65)	θ value	2.52405e-10 (rank : 73)
Query Neighborhood Hits	166	Target Neighborhood Hits	89	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

DDEF1_MOUSE
NC score	0.494562 (rank : 66)	θ value	2.97466e-19 (rank : 15)
Query Neighborhood Hits	166	Target Neighborhood Hits	592	Shared Neighborhood Hits	60
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

STA13_MOUSE
NC score	0.492132 (rank : 67)	θ value	1.133e-10 (rank : 68)
Query Neighborhood Hits	166	Target Neighborhood Hits	89	Shared Neighborhood Hits	56
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

CENG1_MOUSE
NC score	0.491558 (rank : 68)	θ value	4.15078e-21 (rank : 8)
Query Neighborhood Hits	166	Target Neighborhood Hits	531	Shared Neighborhood Hits	49
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

STAR8_MOUSE
NC score	0.489457 (rank : 69)	θ value	7.34386e-10 (rank : 77)
Query Neighborhood Hits	166	Target Neighborhood Hits	101	Shared Neighborhood Hits	57
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STAR8_HUMAN
NC score	0.487303 (rank : 70)	θ value	1.63604e-09 (rank : 81)
Query Neighborhood Hits	166	Target Neighborhood Hits	216	Shared Neighborhood Hits	61
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

CE005_HUMAN
NC score	0.487037 (rank : 71)	θ value	1.74796e-11 (rank : 64)
Query Neighborhood Hits	166	Target Neighborhood Hits	213	Shared Neighborhood Hits	61
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

CENG1_HUMAN
NC score	0.486290 (rank : 72)	θ value	1.09232e-21 (rank : 7)
Query Neighborhood Hits	166	Target Neighborhood Hits	544	Shared Neighborhood Hits	48
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

DDEF2_HUMAN
NC score	0.485135 (rank : 73)	θ value	1.33526e-19 (rank : 12)
Query Neighborhood Hits	166	Target Neighborhood Hits	599	Shared Neighborhood Hits	67
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

CE005_MOUSE
NC score	0.483954 (rank : 74)	θ value	6.00763e-12 (rank : 60)
Query Neighborhood Hits	166	Target Neighborhood Hits	238	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

DDEF2_MOUSE
NC score	0.481062 (rank : 75)	θ value	6.62687e-19 (rank : 16)
Query Neighborhood Hits	166	Target Neighborhood Hits	625	Shared Neighborhood Hits	65
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

CENG3_MOUSE
NC score	0.475372 (rank : 76)	θ value	1.47631e-18 (rank : 18)
Query Neighborhood Hits	166	Target Neighborhood Hits	467	Shared Neighborhood Hits	45
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_HUMAN
NC score	0.475228 (rank : 77)	θ value	1.13037e-18 (rank : 17)
Query Neighborhood Hits	166	Target Neighborhood Hits	455	Shared Neighborhood Hits	44
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

GIT2_HUMAN
NC score	0.458402 (rank : 78)	θ value	4.02038e-16 (rank : 32)
Query Neighborhood Hits	166	Target Neighborhood Hits	381	Shared Neighborhood Hits	43
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

GIT2_MOUSE
NC score	0.456358 (rank : 79)	θ value	1.38178e-16 (rank : 28)
Query Neighborhood Hits	166	Target Neighborhood Hits	323	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

CENG2_MOUSE
NC score	0.454341 (rank : 80)	θ value	1.99529e-15 (rank : 40)
Query Neighborhood Hits	166	Target Neighborhood Hits	463	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

CENG2_HUMAN
NC score	0.451921 (rank : 81)	θ value	2.60593e-15 (rank : 41)
Query Neighborhood Hits	166	Target Neighborhood Hits	471	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

GIT1_HUMAN
NC score	0.448786 (rank : 82)	θ value	1.38178e-16 (rank : 26)
Query Neighborhood Hits	166	Target Neighborhood Hits	336	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

GIT1_MOUSE
NC score	0.447565 (rank : 83)	θ value	1.38178e-16 (rank : 27)
Query Neighborhood Hits	166	Target Neighborhood Hits	341	Shared Neighborhood Hits	39
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

NUPL_HUMAN
NC score	0.357714 (rank : 84)	θ value	0.0113563 (rank : 98)
Query Neighborhood Hits	166	Target Neighborhood Hits	68	Shared Neighborhood Hits	36
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).

NUPL_MOUSE
NC score	0.354138 (rank : 85)	θ value	0.0113563 (rank : 99)
Query Neighborhood Hits	166	Target Neighborhood Hits	113	Shared Neighborhood Hits	36
SwissProt Accessions	Q8K2K6, O70448, Q8BQL5, Q8CDK9	Gene names	Hrb, Rip
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein homolog).

MYO9B_MOUSE
NC score	0.346971 (rank : 86)	θ value	1.5773e-20 (rank : 10)
Query Neighborhood Hits	166	Target Neighborhood Hits	311	Shared Neighborhood Hits	62
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

MYO9B_HUMAN
NC score	0.342646 (rank : 87)	θ value	3.51386e-20 (rank : 11)
Query Neighborhood Hits	166	Target Neighborhood Hits	641	Shared Neighborhood Hits	66
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

K1688_MOUSE
NC score	0.330229 (rank : 88)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	166	Target Neighborhood Hits	188	Shared Neighborhood Hits	62
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

K1688_HUMAN
NC score	0.320336 (rank : 89)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	166	Target Neighborhood Hits	217	Shared Neighborhood Hits	60
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

P85A_HUMAN
NC score	0.316971 (rank : 90)	θ value	3.41135e-07 (rank : 88)
Query Neighborhood Hits	166	Target Neighborhood Hits	479	Shared Neighborhood Hits	67
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

HRBL_HUMAN
NC score	0.316931 (rank : 91)	θ value	0.000786445 (rank : 96)
Query Neighborhood Hits	166	Target Neighborhood Hits	179	Shared Neighborhood Hits	36
SwissProt Accessions	O95081, O75429, Q96AB9, Q96GL4	Gene names	HRBL, RABR
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

P85A_MOUSE
NC score	0.311451 (rank : 92)	θ value	5.81887e-07 (rank : 89)
Query Neighborhood Hits	166	Target Neighborhood Hits	435	Shared Neighborhood Hits	67
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

HRBL_MOUSE
NC score	0.302033 (rank : 93)	θ value	0.00035302 (rank : 93)
Query Neighborhood Hits	166	Target Neighborhood Hits	269	Shared Neighborhood Hits	38
SwissProt Accessions	Q80WC7, Q8BKS5, Q99J67	Gene names	Hrbl, Rabr
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

PKHA1_HUMAN
NC score	0.262595 (rank : 94)	θ value	6.43352e-06 (rank : 91)
Query Neighborhood Hits	166	Target Neighborhood Hits	127	Shared Neighborhood Hits	63
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
NC score	0.258878 (rank : 95)	θ value	1.69304e-06 (rank : 90)
Query Neighborhood Hits	166	Target Neighborhood Hits	120	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA6_MOUSE
NC score	0.224281 (rank : 96)	θ value	2.79066e-09 (rank : 82)
Query Neighborhood Hits	166	Target Neighborhood Hits	591	Shared Neighborhood Hits	67
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_HUMAN
NC score	0.221983 (rank : 97)	θ value	8.11959e-09 (rank : 84)
Query Neighborhood Hits	166	Target Neighborhood Hits	556	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA2_MOUSE
NC score	0.217544 (rank : 98)	θ value	0.00390308 (rank : 97)
Query Neighborhood Hits	166	Target Neighborhood Hits	116	Shared Neighborhood Hits	56
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

OCRL_HUMAN
NC score	0.212646 (rank : 99)	θ value	0.163984 (rank : 113)
Query Neighborhood Hits	166	Target Neighborhood Hits	77	Shared Neighborhood Hits	49
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).

I5P2_HUMAN
NC score	0.210254 (rank : 100)	θ value	1.06291 (rank : 132)
Query Neighborhood Hits	166	Target Neighborhood Hits	86	Shared Neighborhood Hits	50
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

PKHA2_HUMAN
NC score	0.196259 (rank : 101)	θ value	0.0431538 (rank : 104)
Query Neighborhood Hits	166	Target Neighborhood Hits	119	Shared Neighborhood Hits	59
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHA4_MOUSE
NC score	0.165340 (rank : 102)	θ value	0.0330416 (rank : 102)
Query Neighborhood Hits	166	Target Neighborhood Hits	202	Shared Neighborhood Hits	52
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_HUMAN
NC score	0.155792 (rank : 103)	θ value	0.0431538 (rank : 105)
Query Neighborhood Hits	166	Target Neighborhood Hits	283	Shared Neighborhood Hits	52
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA5_HUMAN
NC score	0.145721 (rank : 104)	θ value	0.0563607 (rank : 106)
Query Neighborhood Hits	166	Target Neighborhood Hits	455	Shared Neighborhood Hits	65
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

GAB2_MOUSE
NC score	0.136022 (rank : 105)	θ value	0.000270298 (rank : 92)
Query Neighborhood Hits	166	Target Neighborhood Hits	220	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

DAPP1_MOUSE
NC score	0.135152 (rank : 106)	θ value	0.62314 (rank : 126)
Query Neighborhood Hits	166	Target Neighborhood Hits	225	Shared Neighborhood Hits	62
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

GAB2_HUMAN
NC score	0.132539 (rank : 107)	θ value	0.000461057 (rank : 94)
Query Neighborhood Hits	166	Target Neighborhood Hits	188	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

DAPP1_HUMAN
NC score	0.131443 (rank : 108)	θ value	0.62314 (rank : 125)
Query Neighborhood Hits	166	Target Neighborhood Hits	227	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

GAB1_HUMAN
NC score	0.112324 (rank : 109)	θ value	0.0736092 (rank : 107)
Query Neighborhood Hits	166	Target Neighborhood Hits	279	Shared Neighborhood Hits	36
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

DP13A_HUMAN
NC score	0.109989 (rank : 110)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	166	Target Neighborhood Hits	107	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13A_MOUSE
NC score	0.106948 (rank : 111)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	166	Target Neighborhood Hits	96	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K3H0, Q3UJP7, Q69ZJ9, Q8BWZ8, Q8VCJ8, Q9CUW4	Gene names	Appl1, Dip13a, Kiaa1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

C43BP_MOUSE
NC score	0.105615 (rank : 112)	θ value	0.125558 (rank : 110)
Query Neighborhood Hits	166	Target Neighborhood Hits	91	Shared Neighborhood Hits	43
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

GAB1_MOUSE
NC score	0.105469 (rank : 113)	θ value	0.125558 (rank : 111)
Query Neighborhood Hits	166	Target Neighborhood Hits	233	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

PKHA3_MOUSE
NC score	0.104522 (rank : 114)	θ value	0.163984 (rank : 114)
Query Neighborhood Hits	166	Target Neighborhood Hits	67	Shared Neighborhood Hits	29
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PKHA3_HUMAN
NC score	0.102999 (rank : 115)	θ value	0.0961366 (rank : 109)
Query Neighborhood Hits	166	Target Neighborhood Hits	66	Shared Neighborhood Hits	28
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

DP13B_MOUSE
NC score	0.102341 (rank : 116)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	166	Target Neighborhood Hits	58	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

DGKH_HUMAN
NC score	0.099897 (rank : 117)	θ value	8.99809 (rank : 164)
Query Neighborhood Hits	166	Target Neighborhood Hits	255	Shared Neighborhood Hits	53
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

PLEK_HUMAN
NC score	0.099456 (rank : 118)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	166	Target Neighborhood Hits	110	Shared Neighborhood Hits	56
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

C43BP_HUMAN
NC score	0.099421 (rank : 119)	θ value	0.163984 (rank : 112)
Query Neighborhood Hits	166	Target Neighborhood Hits	87	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

3BP2_HUMAN
NC score	0.098682 (rank : 120)	θ value	0.62314 (rank : 123)
Query Neighborhood Hits	166	Target Neighborhood Hits	296	Shared Neighborhood Hits	45
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

OSBP1_HUMAN
NC score	0.097652 (rank : 121)	θ value	0.0252991 (rank : 101)
Query Neighborhood Hits	166	Target Neighborhood Hits	180	Shared Neighborhood Hits	55
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

DP13B_HUMAN
NC score	0.095560 (rank : 122)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	166	Target Neighborhood Hits	58	Shared Neighborhood Hits	18
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

CYH1_HUMAN
NC score	0.095496 (rank : 123)	θ value	0.62314 (rank : 124)
Query Neighborhood Hits	166	Target Neighborhood Hits	184	Shared Neighborhood Hits	63
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
NC score	0.095282 (rank : 124)	θ value	1.38821 (rank : 134)
Query Neighborhood Hits	166	Target Neighborhood Hits	176	Shared Neighborhood Hits	61
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

MYO10_HUMAN
NC score	0.091864 (rank : 125)	θ value	0.000602161 (rank : 95)
Query Neighborhood Hits	166	Target Neighborhood Hits	920	Shared Neighborhood Hits	73
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

CYH2_HUMAN
NC score	0.090551 (rank : 126)	θ value	0.813845 (rank : 129)
Query Neighborhood Hits	166	Target Neighborhood Hits	175	Shared Neighborhood Hits	60
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
NC score	0.090434 (rank : 127)	θ value	0.813845 (rank : 130)
Query Neighborhood Hits	166	Target Neighborhood Hits	171	Shared Neighborhood Hits	60
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

3BP2_MOUSE
NC score	0.090210 (rank : 128)	θ value	1.81305 (rank : 136)
Query Neighborhood Hits	166	Target Neighborhood Hits	142	Shared Neighborhood Hits	41
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

CYH3_HUMAN
NC score	0.087766 (rank : 129)	θ value	3.0926 (rank : 145)
Query Neighborhood Hits	166	Target Neighborhood Hits	137	Shared Neighborhood Hits	56
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

PLEK2_HUMAN
NC score	0.086385 (rank : 130)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	166	Target Neighborhood Hits	101	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK_MOUSE
NC score	0.085463 (rank : 131)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	166	Target Neighborhood Hits	109	Shared Neighborhood Hits	53
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

PLEK2_MOUSE
NC score	0.082640 (rank : 132)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	166	Target Neighborhood Hits	96	Shared Neighborhood Hits	53
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

CYH3_MOUSE
NC score	0.082613 (rank : 133)	θ value	3.0926 (rank : 146)
Query Neighborhood Hits	166	Target Neighborhood Hits	148	Shared Neighborhood Hits	60
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

P85B_HUMAN
NC score	0.080346 (rank : 134)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	166	Target Neighborhood Hits	543	Shared Neighborhood Hits	30
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

CT086_HUMAN
NC score	0.079926 (rank : 135)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	166	Target Neighborhood Hits	277	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BZ19, Q4VXE6	Gene names	C20orf86
Domain Architecture
Description	Putative uncharacterized protein C20orf86.

CNKR1_HUMAN
NC score	0.076242 (rank : 136)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	166	Target Neighborhood Hits	154	Shared Neighborhood Hits	40
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

OSBL9_HUMAN
NC score	0.076182 (rank : 137)	θ value	2.36792 (rank : 140)
Query Neighborhood Hits	166	Target Neighborhood Hits	138	Shared Neighborhood Hits	49
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

OSBP2_HUMAN
NC score	0.076024 (rank : 138)	θ value	0.0431538 (rank : 103)
Query Neighborhood Hits	166	Target Neighborhood Hits	154	Shared Neighborhood Hits	42
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

CYH4_MOUSE
NC score	0.074495 (rank : 139)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	166	Target Neighborhood Hits	134	Shared Neighborhood Hits	56
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

DGKD_HUMAN
NC score	0.073315 (rank : 140)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	166	Target Neighborhood Hits	231	Shared Neighborhood Hits	35
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

CYH4_HUMAN
NC score	0.073101 (rank : 141)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	166	Target Neighborhood Hits	135	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

OSBP2_MOUSE
NC score	0.070578 (rank : 142)	θ value	0.0736092 (rank : 108)
Query Neighborhood Hits	166	Target Neighborhood Hits	150	Shared Neighborhood Hits	39
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

RASA3_HUMAN
NC score	0.070541 (rank : 143)	θ value	0.163984 (rank : 115)
Query Neighborhood Hits	166	Target Neighborhood Hits	166	Shared Neighborhood Hits	41
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

MTMRD_HUMAN
NC score	0.070333 (rank : 144)	θ value	0.0193708 (rank : 100)
Query Neighborhood Hits	166	Target Neighborhood Hits	135	Shared Neighborhood Hits	48
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

ANR41_HUMAN
NC score	0.069359 (rank : 145)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	166	Target Neighborhood Hits	332	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NAG6, Q8N8J8	Gene names	ANKRD41
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 41.

SWP70_HUMAN
NC score	0.068394 (rank : 146)	θ value	0.365318 (rank : 119)
Query Neighborhood Hits	166	Target Neighborhood Hits	973	Shared Neighborhood Hits	65
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
NC score	0.067790 (rank : 147)	θ value	0.365318 (rank : 120)
Query Neighborhood Hits	166	Target Neighborhood Hits	1097	Shared Neighborhood Hits	68
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

RASA2_MOUSE
NC score	0.065866 (rank : 148)	θ value	2.36792 (rank : 141)
Query Neighborhood Hits	166	Target Neighborhood Hits	159	Shared Neighborhood Hits	43
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

ANR37_MOUSE
NC score	0.064791 (rank : 149)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	166	Target Neighborhood Hits	237	Shared Neighborhood Hits	19
SwissProt Accessions	Q569N2, Q8CHS0	Gene names	Ankrd37
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37.

P85B_MOUSE
NC score	0.063454 (rank : 150)	θ value	3.0926 (rank : 148)
Query Neighborhood Hits	166	Target Neighborhood Hits	519	Shared Neighborhood Hits	27
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

GNRP_HUMAN
NC score	0.062489 (rank : 151)	θ value	0.47712 (rank : 121)
Query Neighborhood Hits	166	Target Neighborhood Hits	239	Shared Neighborhood Hits	46
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

ANR46_HUMAN
NC score	0.061529 (rank : 152)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	166	Target Neighborhood Hits	281	Shared Neighborhood Hits	20
SwissProt Accessions	Q86W74, Q6P9B7	Gene names	ANKRD46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

RASA1_HUMAN
NC score	0.061406 (rank : 153)	θ value	1.06291 (rank : 133)
Query Neighborhood Hits	166	Target Neighborhood Hits	258	Shared Neighborhood Hits	44
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

ANR46_MOUSE
NC score	0.060952 (rank : 154)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	166	Target Neighborhood Hits	274	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BTZ5, Q1LZK9, Q8BV97	Gene names	Ankrd46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

GRP3_HUMAN
NC score	0.060939 (rank : 155)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	166	Target Neighborhood Hits	131	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

GNRP_MOUSE
NC score	0.060257 (rank : 156)	θ value	0.47712 (rank : 122)
Query Neighborhood Hits	166	Target Neighborhood Hits	191	Shared Neighborhood Hits	43
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

TNKS1_HUMAN
NC score	0.059783 (rank : 157)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	166	Target Neighborhood Hits	477	Shared Neighborhood Hits	27
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

IKBB_MOUSE
NC score	0.059226 (rank : 158)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	166	Target Neighborhood Hits	284	Shared Neighborhood Hits	21
SwissProt Accessions	Q60778, Q9D6L5	Gene names	Nfkbib, Ikbb
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B).

ANR39_MOUSE
NC score	0.058700 (rank : 159)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	166	Target Neighborhood Hits	284	Shared Neighborhood Hits	21
SwissProt Accessions	Q9D2X0	Gene names	Ankrd39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

RASA3_MOUSE
NC score	0.058526 (rank : 160)	θ value	3.0926 (rank : 149)
Query Neighborhood Hits	166	Target Neighborhood Hits	144	Shared Neighborhood Hits	38
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

AB1IP_HUMAN
NC score	0.058461 (rank : 161)	θ value	0.279714 (rank : 117)
Query Neighborhood Hits	166	Target Neighborhood Hits	213	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

RASA2_HUMAN
NC score	0.057826 (rank : 162)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	166	Target Neighborhood Hits	157	Shared Neighborhood Hits	38
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

CSKI2_MOUSE
NC score	0.057411 (rank : 163)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	166	Target Neighborhood Hits	812	Shared Neighborhood Hits	36
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

ANR39_HUMAN
NC score	0.057341 (rank : 164)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	166	Target Neighborhood Hits	285	Shared Neighborhood Hits	21
SwissProt Accessions	Q53RE8, Q59FU2, Q8N5X5, Q9P0S5	Gene names	ANKRD39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

CNKR2_MOUSE
NC score	0.057205 (rank : 165)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	166	Target Neighborhood Hits	197	Shared Neighborhood Hits	39
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CSKI2_HUMAN
NC score	0.056430 (rank : 166)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	166	Target Neighborhood Hits	747	Shared Neighborhood Hits	34
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CNKR2_HUMAN
NC score	0.056382 (rank : 167)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	166	Target Neighborhood Hits	197	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

ANS4B_MOUSE
NC score	0.055907 (rank : 168)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	166	Target Neighborhood Hits	294	Shared Neighborhood Hits	19
SwissProt Accessions	Q8K3X6, Q9D8A5	Gene names	Anks4b, Harp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

AB1IP_MOUSE
NC score	0.055793 (rank : 169)	θ value	0.21417 (rank : 116)
Query Neighborhood Hits	166	Target Neighborhood Hits	181	Shared Neighborhood Hits	17
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

ANR37_HUMAN
NC score	0.055505 (rank : 170)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	166	Target Neighborhood Hits	247	Shared Neighborhood Hits	18
SwissProt Accessions	Q7Z713	Gene names	ANKRD37, LPR2BP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37 (Low-density lipoprotein receptor-related protein 2-binding protein) (hLrp2bp).

TNKS2_HUMAN
NC score	0.055303 (rank : 171)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	166	Target Neighborhood Hits	361	Shared Neighborhood Hits	26
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

GABP3_MOUSE
NC score	0.054634 (rank : 172)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	166	Target Neighborhood Hits	330	Shared Neighborhood Hits	22
SwissProt Accessions	P81069	Gene names	Gabpb2
Domain Architecture	No domain graphic available
Description	GA-binding protein beta-2-1 chain (GABP subunit beta-2-1) (GABPB2-1).

IASPP_MOUSE
NC score	0.054528 (rank : 173)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	166	Target Neighborhood Hits	1024	Shared Neighborhood Hits	38
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

MRIP_MOUSE
NC score	0.053681 (rank : 174)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	166	Target Neighborhood Hits	569	Shared Neighborhood Hits	50
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

FA13A_MOUSE
NC score	0.053527 (rank : 175)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	166	Target Neighborhood Hits	83	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BGI4, Q8BZ91	Gene names	Fam13a1, Precm1
Domain Architecture	No domain graphic available
Description	Protein FAM13A1 (Precm1 protein).

FARP1_HUMAN
NC score	0.053219 (rank : 176)	θ value	3.0926 (rank : 147)
Query Neighborhood Hits	166	Target Neighborhood Hits	241	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

PCTL_MOUSE
NC score	0.052776 (rank : 177)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	166	Target Neighborhood Hits	26	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JMD3	Gene names	Stard10, Pctpl, Sdccag28, Sdccagg28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28 homolog).

FA13A_HUMAN
NC score	0.052673 (rank : 178)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	166	Target Neighborhood Hits	102	Shared Neighborhood Hits	2
SwissProt Accessions	O94988, Q8NBA3	Gene names	FAM13A1, KIAA0914
Domain Architecture	No domain graphic available
Description	Protein FAM13A1.

GABP2_HUMAN
NC score	0.052548 (rank : 179)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	166	Target Neighborhood Hits	454	Shared Neighborhood Hits	23
SwissProt Accessions	Q06547, Q06545, Q12940, Q12941, Q12942, Q8IYD0	Gene names	GABPB2, E4TF1B, GABPB, GABPB1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1) (Transcription factor E4TF1-53) (Transcription factor E4TF1-47) (Nuclear respiratory factor 2).

GABP2_MOUSE
NC score	0.052484 (rank : 180)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	166	Target Neighborhood Hits	429	Shared Neighborhood Hits	23
SwissProt Accessions	Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2	Gene names	Gabpb2, Gabpb, Gabpb1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1).

PCTL_HUMAN
NC score	0.052164 (rank : 181)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	166	Target Neighborhood Hits	26	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y365, O60532	Gene names	STARD10, SDCCAG28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28) (Antigen NY-CO-28).

PKHB2_MOUSE
NC score	0.051688 (rank : 182)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	166	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

MTMR5_HUMAN
NC score	0.051477 (rank : 183)	θ value	0.279714 (rank : 118)
Query Neighborhood Hits	166	Target Neighborhood Hits	141	Shared Neighborhood Hits	39
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

IKBB_HUMAN
NC score	0.050808 (rank : 184)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	166	Target Neighborhood Hits	284	Shared Neighborhood Hits	21
SwissProt Accessions	Q15653, Q96BJ7	Gene names	NFKBIB, IKBB, TRIP9
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9).

ANS4B_HUMAN
NC score	0.050783 (rank : 185)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	166	Target Neighborhood Hits	289	Shared Neighborhood Hits	19
SwissProt Accessions	Q8N8V4	Gene names	ANKS4B, HARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

HECD1_HUMAN
NC score	0.050004 (rank : 186)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	166	Target Neighborhood Hits	371	Shared Neighborhood Hits	22
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

MTPN_MOUSE
NC score	0.050002 (rank : 187)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	166	Target Neighborhood Hits	269	Shared Neighborhood Hits	19
SwissProt Accessions	P62774, P80144, Q543M6, Q9DCN8	Gene names	Mtpn, Gcdp
Domain Architecture	No domain graphic available
Description	Myotrophin (Protein V-1) (Granule cell differentiation protein).

FGD4_MOUSE
NC score	0.047570 (rank : 188)	θ value	4.03905 (rank : 154)
Query Neighborhood Hits	166	Target Neighborhood Hits	227	Shared Neighborhood Hits	42
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD6_HUMAN
NC score	0.047040 (rank : 189)	θ value	5.27518 (rank : 156)
Query Neighborhood Hits	166	Target Neighborhood Hits	237	Shared Neighborhood Hits	49
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FARP2_HUMAN
NC score	0.045568 (rank : 190)	θ value	0.62314 (rank : 127)
Query Neighborhood Hits	166	Target Neighborhood Hits	240	Shared Neighborhood Hits	40
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ANLN_MOUSE
NC score	0.043935 (rank : 191)	θ value	0.813845 (rank : 128)
Query Neighborhood Hits	166	Target Neighborhood Hits	297	Shared Neighborhood Hits	20
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

ANR28_MOUSE
NC score	0.043682 (rank : 192)	θ value	2.36792 (rank : 139)
Query Neighborhood Hits	166	Target Neighborhood Hits	314	Shared Neighborhood Hits	22
SwissProt Accessions	Q505D1	Gene names	Ankrd28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ANR28_HUMAN
NC score	0.043420 (rank : 193)	θ value	1.81305 (rank : 137)
Query Neighborhood Hits	166	Target Neighborhood Hits	314	Shared Neighborhood Hits	22
SwissProt Accessions	O15084, Q6ULS0, Q6ZT57	Gene names	ANKRD28, KIAA0379
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ANLN_HUMAN
NC score	0.042437 (rank : 194)	θ value	4.03905 (rank : 150)
Query Neighborhood Hits	166	Target Neighborhood Hits	222	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NQW6, Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0	Gene names	ANLN
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

FGD4_HUMAN
NC score	0.036948 (rank : 195)	θ value	8.99809 (rank : 165)
Query Neighborhood Hits	166	Target Neighborhood Hits	219	Shared Neighborhood Hits	41
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

K1914_HUMAN
NC score	0.032167 (rank : 196)	θ value	1.81305 (rank : 138)
Query Neighborhood Hits	166	Target Neighborhood Hits	255	Shared Neighborhood Hits	22
SwissProt Accessions	Q8N4X5, Q8TB54, Q96PX4, Q96SY5	Gene names	KIAA1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

FGD5_HUMAN
NC score	0.031246 (rank : 197)	θ value	8.99809 (rank : 166)
Query Neighborhood Hits	166	Target Neighborhood Hits	235	Shared Neighborhood Hits	36
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

DOCK9_HUMAN
NC score	0.027496 (rank : 198)	θ value	4.03905 (rank : 153)
Query Neighborhood Hits	166	Target Neighborhood Hits	82	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BZ29, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4	Gene names	DOCK9, KIAA1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

SYGP1_HUMAN
NC score	0.026768 (rank : 199)	θ value	2.36792 (rank : 143)
Query Neighborhood Hits	166	Target Neighborhood Hits	589	Shared Neighborhood Hits	18
SwissProt Accessions	Q96PV0, Q8TCS2, Q9UGE2	Gene names	SYNGAP1, KIAA1938
Domain Architecture
Description	Ras GTPase-activating protein SynGAP (Synaptic Ras-GTPase-activating protein 1) (Synaptic Ras-GAP 1) (Neuronal RasGAP).

ANR25_MOUSE
NC score	0.021796 (rank : 200)	θ value	8.99809 (rank : 163)
Query Neighborhood Hits	166	Target Neighborhood Hits	398	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BX02, Q8BLD5, Q91Z35	Gene names	Ankrd25
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25.

DAB2P_HUMAN
NC score	0.021252 (rank : 201)	θ value	4.03905 (rank : 151)
Query Neighborhood Hits	166	Target Neighborhood Hits	303	Shared Neighborhood Hits	13
SwissProt Accessions	Q5VWQ8, Q8TDL2, Q96SE1, Q9C0C0	Gene names	DAB2IP, AF9Q34, AIP1, KIAA1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein) (DAB2 interaction protein) (ASK-interacting protein 1).

DAB2P_MOUSE
NC score	0.021055 (rank : 202)	θ value	4.03905 (rank : 152)
Query Neighborhood Hits	166	Target Neighborhood Hits	284	Shared Neighborhood Hits	12
SwissProt Accessions	Q3UHC7, Q3TPD5, Q3UH44, Q6JTV1, Q80T97	Gene names	Dab2ip, Kiaa1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein).

SOS1_HUMAN
NC score	0.018762 (rank : 203)	θ value	1.38821 (rank : 135)
Query Neighborhood Hits	166	Target Neighborhood Hits	274	Shared Neighborhood Hits	14
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SPTN4_HUMAN
NC score	0.018389 (rank : 204)	θ value	0.813845 (rank : 131)
Query Neighborhood Hits	166	Target Neighborhood Hits	570	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

SPTN5_HUMAN
NC score	0.010822 (rank : 205)	θ value	5.27518 (rank : 158)
Query Neighborhood Hits	166	Target Neighborhood Hits	674	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

HPS3_MOUSE
NC score	0.010102 (rank : 206)	θ value	6.88961 (rank : 159)
Query Neighborhood Hits	166	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q91VB4, Q8VDX2, Q8VHT1	Gene names	Hps3, Coa
Domain Architecture	No domain graphic available
Description	Hermansky-Pudlak syndrome 3 protein homolog (Cocoa protein).

SPG3A_MOUSE
NC score	0.009853 (rank : 207)	θ value	5.27518 (rank : 157)
Query Neighborhood Hits	166	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BH66, Q8BJH5	Gene names	Spg3a, Gbp3
Domain Architecture
Description	Atlastin (GTP-binding protein 3) (Guanine nucleotide-binding protein 3) (GBP-3).

SV2B_MOUSE
NC score	0.006617 (rank : 208)	θ value	2.36792 (rank : 142)
Query Neighborhood Hits	166	Target Neighborhood Hits	75	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BG39, Q80TT1, Q9ES95	Gene names	Sv2b, Kiaa0735
Domain Architecture	No domain graphic available
Description	Synaptic vesicle glycoprotein 2B (Synaptic vesicle protein 2B).

TLN1_HUMAN
NC score	0.005641 (rank : 209)	θ value	6.88961 (rank : 161)
Query Neighborhood Hits	166	Target Neighborhood Hits	218	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

TLN1_MOUSE
NC score	0.005118 (rank : 210)	θ value	6.88961 (rank : 162)
Query Neighborhood Hits	166	Target Neighborhood Hits	213	Shared Neighborhood Hits	7
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

MMEL1_HUMAN
NC score	0.004568 (rank : 211)	θ value	4.03905 (rank : 155)
Query Neighborhood Hits	166	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	Q495T6, Q495T7, Q495T8, Q5SZS6, Q96PH9	Gene names	MMEL1, MELL1, MMEL2, NEP2
Domain Architecture	No domain graphic available
Description	Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (Neprilysin-2) (Neprilysin II) (NL2) (NEPII) (NEP2(m)) [Contains: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))].

THIM_MOUSE
NC score	0.004117 (rank : 212)	θ value	6.88961 (rank : 160)
Query Neighborhood Hits	166	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BWT1, Q8JZR8	Gene names	Acaa2
Domain Architecture	No domain graphic available
Description	3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Beta- ketothiolase) (Acetyl-CoA acyltransferase) (Mitochondrial 3-oxoacyl- CoA thiolase).

TEC_MOUSE
NC score	0.004016 (rank : 213)	θ value	2.36792 (rank : 144)
Query Neighborhood Hits	166	Target Neighborhood Hits	1006	Shared Neighborhood Hits	36
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).