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Network neighborhood for query Sequence : OCRL_HUMAN

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OCRL_HUMAN
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

I5P2_HUMAN
θ value	0 (rank : 1)	NC score	0.975892 (rank : 2)
Query Neighborhood Hits	77	Target Neighborhood Hits	86	Shared Neighborhood Hits	58
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

OCRL_HUMAN
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	77	Target Neighborhood Hits	77	Shared Neighborhood Hits	77
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).

SYNJ2_HUMAN
θ value	4.24587e-58 (rank : 3)	NC score	0.766504 (rank : 6)
Query Neighborhood Hits	77	Target Neighborhood Hits	136	Shared Neighborhood Hits	14
SwissProt Accessions	O15056, Q5TA13, Q5TA16, Q5TA19, Q86XK0, Q8IZA8, Q9H226	Gene names	SYNJ2, KIAA0348
Domain Architecture	No domain graphic available
Description	Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 2).

SYNJ2_MOUSE
θ value	8.00737e-57 (rank : 4)	NC score	0.773088 (rank : 5)
Query Neighborhood Hits	77	Target Neighborhood Hits	87	Shared Neighborhood Hits	13
SwissProt Accessions	Q9D2G5, O35404, O88399, O88400, O88401, O88402, O88403, O88404	Gene names	Synj2, Kiaa0348
Domain Architecture
Description	Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 2).

SYNJ1_MOUSE
θ value	4.85792e-54 (rank : 5)	NC score	0.702311 (rank : 11)
Query Neighborhood Hits	77	Target Neighborhood Hits	516	Shared Neighborhood Hits	17
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

SYNJ1_HUMAN
θ value	5.37103e-53 (rank : 6)	NC score	0.703498 (rank : 10)
Query Neighborhood Hits	77	Target Neighborhood Hits	498	Shared Neighborhood Hits	21
SwissProt Accessions	O43426, O43425, O94984	Gene names	SYNJ1, KIAA0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

PI5PA_HUMAN
θ value	5.95217e-44 (rank : 7)	NC score	0.664747 (rank : 12)
Query Neighborhood Hits	77	Target Neighborhood Hits	749	Shared Neighborhood Hits	18
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

PI5PA_MOUSE
θ value	5.95217e-44 (rank : 8)	NC score	0.735614 (rank : 7)
Query Neighborhood Hits	77	Target Neighborhood Hits	331	Shared Neighborhood Hits	19
SwissProt Accessions	P59644	Gene names	Pib5pa
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

SKIP_MOUSE
θ value	7.52953e-39 (rank : 9)	NC score	0.797671 (rank : 3)
Query Neighborhood Hits	77	Target Neighborhood Hits	18	Shared Neighborhood Hits	13
SwissProt Accessions	Q8C5L6, O09040	Gene names	Skip, Pps
Domain Architecture
Description	Skeletal muscle and kidney-enriched inositol phosphatase (EC 3.1.3.56).

SKIP_HUMAN
θ value	2.05049e-36 (rank : 10)	NC score	0.796797 (rank : 4)
Query Neighborhood Hits	77	Target Neighborhood Hits	16	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BT40, Q15733, Q9NPJ5, Q9P2R5	Gene names	SKIP, PPS
Domain Architecture
Description	Skeletal muscle and kidney-enriched inositol phosphatase (EC 3.1.3.56).

INP5E_MOUSE
θ value	5.59698e-26 (rank : 11)	NC score	0.734694 (rank : 8)
Query Neighborhood Hits	77	Target Neighborhood Hits	59	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JII1, Q3TCC9	Gene names	Inpp5e
Domain Architecture
Description	72 kDa inositol polyphosphate 5-phosphatase (EC 3.1.3.36) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (Phosphatidylinositol polyphosphate 5-phosphatase type IV).

INP5E_HUMAN
θ value	9.54697e-26 (rank : 12)	NC score	0.711803 (rank : 9)
Query Neighborhood Hits	77	Target Neighborhood Hits	201	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NRR6, Q15734	Gene names	INPP5E
Domain Architecture
Description	72 kDa inositol polyphosphate 5-phosphatase (EC 3.1.3.36) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (Phosphatidylinositol polyphosphate 5-phosphatase type IV).

RHG08_HUMAN
θ value	6.21693e-09 (rank : 13)	NC score	0.384201 (rank : 13)
Query Neighborhood Hits	77	Target Neighborhood Hits	88	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NSG0, O75983, O95695, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NVX8, Q9NXL1, Q9UH20	Gene names	ARHGAP8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

RHG08_MOUSE
θ value	5.26297e-08 (rank : 14)	NC score	0.381499 (rank : 14)
Query Neighborhood Hits	77	Target Neighborhood Hits	73	Shared Neighborhood Hits	51
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

RHG25_MOUSE
θ value	8.97725e-08 (rank : 15)	NC score	0.364365 (rank : 15)
Query Neighborhood Hits	77	Target Neighborhood Hits	492	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

CHIO_HUMAN
θ value	1.53129e-07 (rank : 16)	NC score	0.332259 (rank : 25)
Query Neighborhood Hits	77	Target Neighborhood Hits	220	Shared Neighborhood Hits	50
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

RHG25_HUMAN
θ value	3.41135e-07 (rank : 17)	NC score	0.346680 (rank : 21)
Query Neighborhood Hits	77	Target Neighborhood Hits	550	Shared Neighborhood Hits	49
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

CHIO_MOUSE
θ value	4.45536e-07 (rank : 18)	NC score	0.344269 (rank : 23)
Query Neighborhood Hits	77	Target Neighborhood Hits	130	Shared Neighborhood Hits	50
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

SRGP2_HUMAN
θ value	2.88788e-06 (rank : 19)	NC score	0.321228 (rank : 31)
Query Neighborhood Hits	77	Target Neighborhood Hits	331	Shared Neighborhood Hits	51
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

3BP1_HUMAN
θ value	3.77169e-06 (rank : 20)	NC score	0.362415 (rank : 16)
Query Neighborhood Hits	77	Target Neighborhood Hits	376	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

GMIP_HUMAN
θ value	4.92598e-06 (rank : 21)	NC score	0.360686 (rank : 18)
Query Neighborhood Hits	77	Target Neighborhood Hits	225	Shared Neighborhood Hits	52
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

RHG06_HUMAN
θ value	8.40245e-06 (rank : 22)	NC score	0.344616 (rank : 22)
Query Neighborhood Hits	77	Target Neighborhood Hits	114	Shared Neighborhood Hits	51
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

SRGP2_MOUSE
θ value	8.40245e-06 (rank : 23)	NC score	0.317749 (rank : 32)
Query Neighborhood Hits	77	Target Neighborhood Hits	324	Shared Neighborhood Hits	52
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

CHIN_HUMAN
θ value	1.09739e-05 (rank : 24)	NC score	0.323130 (rank : 28)
Query Neighborhood Hits	77	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

RHG06_MOUSE
θ value	1.43324e-05 (rank : 25)	NC score	0.340490 (rank : 24)
Query Neighborhood Hits	77	Target Neighborhood Hits	105	Shared Neighborhood Hits	51
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

GMIP_MOUSE
θ value	2.44474e-05 (rank : 26)	NC score	0.352211 (rank : 20)
Query Neighborhood Hits	77	Target Neighborhood Hits	202	Shared Neighborhood Hits	51
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

RHG01_HUMAN
θ value	2.44474e-05 (rank : 27)	NC score	0.360911 (rank : 17)
Query Neighborhood Hits	77	Target Neighborhood Hits	75	Shared Neighborhood Hits	51
SwissProt Accessions	Q07960	Gene names	ARHGAP1, CDC42GAP, RHOGAP1
Domain Architecture
Description	Rho-GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (CDC42 GTPase-activating protein) (p50-RhoGAP).

CHIN_MOUSE
θ value	4.1701e-05 (rank : 28)	NC score	0.322177 (rank : 30)
Query Neighborhood Hits	77	Target Neighborhood Hits	229	Shared Neighborhood Hits	51
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

3BP1_MOUSE
θ value	5.44631e-05 (rank : 29)	NC score	0.354510 (rank : 19)
Query Neighborhood Hits	77	Target Neighborhood Hits	238	Shared Neighborhood Hits	52
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

MYO9B_HUMAN
θ value	5.44631e-05 (rank : 30)	NC score	0.177514 (rank : 70)
Query Neighborhood Hits	77	Target Neighborhood Hits	641	Shared Neighborhood Hits	56
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

I5P1_HUMAN
θ value	7.1131e-05 (rank : 31)	NC score	0.246273 (rank : 56)
Query Neighborhood Hits	77	Target Neighborhood Hits	15	Shared Neighborhood Hits	12
SwissProt Accessions	Q14642, Q14640	Gene names	INPP5A
Domain Architecture
Description	Type I inositol-1,4,5-trisphosphate 5-phosphatase (EC 3.1.3.56) (5PTase).

P85A_MOUSE
θ value	9.29e-05 (rank : 32)	NC score	0.201868 (rank : 64)
Query Neighborhood Hits	77	Target Neighborhood Hits	435	Shared Neighborhood Hits	50
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

RHG12_MOUSE
θ value	9.29e-05 (rank : 33)	NC score	0.323485 (rank : 27)
Query Neighborhood Hits	77	Target Neighborhood Hits	204	Shared Neighborhood Hits	51
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

TCGAP_HUMAN
θ value	9.29e-05 (rank : 34)	NC score	0.300028 (rank : 42)
Query Neighborhood Hits	77	Target Neighborhood Hits	872	Shared Neighborhood Hits	58
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	9.29e-05 (rank : 35)	NC score	0.331420 (rank : 26)
Query Neighborhood Hits	77	Target Neighborhood Hits	409	Shared Neighborhood Hits	55
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

K1688_MOUSE
θ value	0.000121331 (rank : 36)	NC score	0.304116 (rank : 39)
Query Neighborhood Hits	77	Target Neighborhood Hits	188	Shared Neighborhood Hits	48
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

K1688_HUMAN
θ value	0.000158464 (rank : 37)	NC score	0.301858 (rank : 40)
Query Neighborhood Hits	77	Target Neighborhood Hits	217	Shared Neighborhood Hits	49
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

P85A_HUMAN
θ value	0.00020696 (rank : 38)	NC score	0.199835 (rank : 66)
Query Neighborhood Hits	77	Target Neighborhood Hits	479	Shared Neighborhood Hits	49
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SRGP1_HUMAN
θ value	0.00020696 (rank : 39)	NC score	0.306736 (rank : 36)
Query Neighborhood Hits	77	Target Neighborhood Hits	390	Shared Neighborhood Hits	51
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

RHG05_MOUSE
θ value	0.000461057 (rank : 40)	NC score	0.314315 (rank : 33)
Query Neighborhood Hits	77	Target Neighborhood Hits	165	Shared Neighborhood Hits	51
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG05_HUMAN
θ value	0.000786445 (rank : 41)	NC score	0.304501 (rank : 38)
Query Neighborhood Hits	77	Target Neighborhood Hits	158	Shared Neighborhood Hits	51
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

FNBP2_HUMAN
θ value	0.00102713 (rank : 42)	NC score	0.311430 (rank : 35)
Query Neighborhood Hits	77	Target Neighborhood Hits	432	Shared Neighborhood Hits	52
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

MYO9B_MOUSE
θ value	0.00102713 (rank : 43)	NC score	0.169966 (rank : 73)
Query Neighborhood Hits	77	Target Neighborhood Hits	311	Shared Neighborhood Hits	52
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

ABR_HUMAN
θ value	0.00665767 (rank : 44)	NC score	0.284636 (rank : 46)
Query Neighborhood Hits	77	Target Neighborhood Hits	166	Shared Neighborhood Hits	51
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

CE005_MOUSE
θ value	0.00869519 (rank : 45)	NC score	0.281637 (rank : 49)
Query Neighborhood Hits	77	Target Neighborhood Hits	238	Shared Neighborhood Hits	50
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

OPHN1_HUMAN
θ value	0.0113563 (rank : 46)	NC score	0.286167 (rank : 44)
Query Neighborhood Hits	77	Target Neighborhood Hits	161	Shared Neighborhood Hits	52
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

RHG04_HUMAN
θ value	0.0113563 (rank : 47)	NC score	0.306221 (rank : 37)
Query Neighborhood Hits	77	Target Neighborhood Hits	307	Shared Neighborhood Hits	53
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

CE005_HUMAN
θ value	0.0148317 (rank : 48)	NC score	0.280779 (rank : 51)
Query Neighborhood Hits	77	Target Neighborhood Hits	213	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

GRLF1_HUMAN
θ value	0.0148317 (rank : 49)	NC score	0.313967 (rank : 34)
Query Neighborhood Hits	77	Target Neighborhood Hits	167	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

BCR_HUMAN
θ value	0.0252991 (rank : 50)	NC score	0.281142 (rank : 50)
Query Neighborhood Hits	77	Target Neighborhood Hits	204	Shared Neighborhood Hits	51
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

OPHN1_MOUSE
θ value	0.0252991 (rank : 51)	NC score	0.283732 (rank : 47)
Query Neighborhood Hits	77	Target Neighborhood Hits	174	Shared Neighborhood Hits	51
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

RHG18_MOUSE
θ value	0.0431538 (rank : 52)	NC score	0.284740 (rank : 45)
Query Neighborhood Hits	77	Target Neighborhood Hits	110	Shared Neighborhood Hits	50
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

RHG07_HUMAN
θ value	0.0563607 (rank : 53)	NC score	0.234698 (rank : 58)
Query Neighborhood Hits	77	Target Neighborhood Hits	108	Shared Neighborhood Hits	51
SwissProt Accessions	Q96QB1, O14868, O43199, Q9C0E0	Gene names	DLC1, ARHGAP7, KIAA1723, STARD12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

RHG09_HUMAN
θ value	0.0563607 (rank : 54)	NC score	0.322843 (rank : 29)
Query Neighborhood Hits	77	Target Neighborhood Hits	186	Shared Neighborhood Hits	52
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

CEND2_HUMAN
θ value	0.163984 (rank : 55)	NC score	0.212646 (rank : 61)
Query Neighborhood Hits	77	Target Neighborhood Hits	166	Shared Neighborhood Hits	49
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

RHG07_MOUSE
θ value	0.21417 (rank : 56)	NC score	0.235138 (rank : 57)
Query Neighborhood Hits	77	Target Neighborhood Hits	103	Shared Neighborhood Hits	51
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

PROL4_HUMAN
θ value	0.47712 (rank : 57)	NC score	0.076271 (rank : 76)
Query Neighborhood Hits	77	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	Q16378, Q8NFB3	Gene names	PRR4, LPRP, PROL4
Domain Architecture	No domain graphic available
Description	Proline-rich protein 4 precursor (Lacrimal proline-rich protein) (Nasopharyngeal carcinoma-associated proline-rich protein 4).

RGAP1_HUMAN
θ value	0.813845 (rank : 58)	NC score	0.283133 (rank : 48)
Query Neighborhood Hits	77	Target Neighborhood Hits	189	Shared Neighborhood Hits	50
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

SF3A1_MOUSE
θ value	0.813845 (rank : 59)	NC score	0.031958 (rank : 86)
Query Neighborhood Hits	77	Target Neighborhood Hits	198	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K4Z5, Q8C0M7, Q8C128, Q8C175, Q921T3	Gene names	Sf3a1
Domain Architecture	No domain graphic available
Description	Splicing factor 3 subunit 1 (SF3a120).

TAGAP_MOUSE
θ value	1.06291 (rank : 60)	NC score	0.273566 (rank : 52)
Query Neighborhood Hits	77	Target Neighborhood Hits	83	Shared Neighborhood Hits	49
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

OGFR_HUMAN
θ value	1.38821 (rank : 61)	NC score	0.056734 (rank : 82)
Query Neighborhood Hits	77	Target Neighborhood Hits	1582	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

RGAP1_MOUSE
θ value	1.38821 (rank : 62)	NC score	0.286606 (rank : 43)
Query Neighborhood Hits	77	Target Neighborhood Hits	185	Shared Neighborhood Hits	50
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

TAGAP_HUMAN
θ value	1.38821 (rank : 63)	NC score	0.268461 (rank : 54)
Query Neighborhood Hits	77	Target Neighborhood Hits	82	Shared Neighborhood Hits	48
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

CEND1_HUMAN
θ value	2.36792 (rank : 64)	NC score	0.159616 (rank : 75)
Query Neighborhood Hits	77	Target Neighborhood Hits	284	Shared Neighborhood Hits	47
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CEND1_MOUSE
θ value	4.03905 (rank : 65)	NC score	0.166663 (rank : 74)
Query Neighborhood Hits	77	Target Neighborhood Hits	260	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

I27RA_HUMAN
θ value	4.03905 (rank : 66)	NC score	0.013485 (rank : 89)
Query Neighborhood Hits	77	Target Neighborhood Hits	60	Shared Neighborhood Hits	2
SwissProt Accessions	Q6UWB1, O60624	Gene names	IL27RA, CRL1, TCCR, WSX1
Domain Architecture	No domain graphic available
Description	Interleukin-27 receptor alpha chain precursor (IL-27R-alpha) (WSX-1) (Type I T-cell cytokine receptor) (TCCR) (Protein CRL1).

LATS1_HUMAN
θ value	4.03905 (rank : 67)	NC score	-0.002308 (rank : 98)
Query Neighborhood Hits	77	Target Neighborhood Hits	1057	Shared Neighborhood Hits	4
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

ANK3_HUMAN
θ value	5.27518 (rank : 68)	NC score	0.001669 (rank : 97)
Query Neighborhood Hits	77	Target Neighborhood Hits	853	Shared Neighborhood Hits	5
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

HXB4_HUMAN
θ value	5.27518 (rank : 69)	NC score	0.003925 (rank : 95)
Query Neighborhood Hits	77	Target Neighborhood Hits	376	Shared Neighborhood Hits	5
SwissProt Accessions	P17483, Q9NTA0	Gene names	HOXB4, HOX2F
Domain Architecture
Description	Homeobox protein Hox-B4 (Hox-2F) (Hox-2.6).

HXB4_MOUSE
θ value	5.27518 (rank : 70)	NC score	0.004311 (rank : 94)
Query Neighborhood Hits	77	Target Neighborhood Hits	375	Shared Neighborhood Hits	6
SwissProt Accessions	P10284, Q3UZB4, Q4VBG0	Gene names	Hoxb4, Hox-2.6, Hoxb-4
Domain Architecture
Description	Homeobox protein Hox-B4 (Hox-2.6).

NCOR1_HUMAN
θ value	5.27518 (rank : 71)	NC score	0.015466 (rank : 88)
Query Neighborhood Hits	77	Target Neighborhood Hits	577	Shared Neighborhood Hits	9
SwissProt Accessions	O75376, Q9UPV5, Q9UQ18	Gene names	NCOR1, KIAA1047
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR).

ANR25_HUMAN
θ value	6.88961 (rank : 72)	NC score	0.003858 (rank : 96)
Query Neighborhood Hits	77	Target Neighborhood Hits	350	Shared Neighborhood Hits	4
SwissProt Accessions	Q63ZY3, Q3KQZ3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210	Gene names	ANKRD25, KIAA1518, SIP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25 (SRC-1-interacting protein) (SRC1-interacting protein).

MS3L1_MOUSE
θ value	6.88961 (rank : 73)	NC score	0.011702 (rank : 90)
Query Neighborhood Hits	77	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WVG9	Gene names	Msl3l1, Msl31
Domain Architecture
Description	Male-specific lethal 3-like 1 (MSL3-like 1) (Male-specific lethal-3 homolog 1).

RRMJ3_MOUSE
θ value	6.88961 (rank : 74)	NC score	0.009551 (rank : 91)
Query Neighborhood Hits	77	Target Neighborhood Hits	163	Shared Neighborhood Hits	2
SwissProt Accessions	Q9DBE9, Q3ULI1, Q921I7	Gene names	Ftsj3
Domain Architecture	No domain graphic available
Description	Putative rRNA methyltransferase 3 (EC 2.1.1.-) (rRNA (uridine-2'-O-)- methyltransferase 3).

SF3A1_HUMAN
θ value	6.88961 (rank : 75)	NC score	0.023988 (rank : 87)
Query Neighborhood Hits	77	Target Neighborhood Hits	199	Shared Neighborhood Hits	6
SwissProt Accessions	Q15459	Gene names	SF3A1, SAP114
Domain Architecture
Description	Splicing factor 3 subunit 1 (Spliceosome-associated protein 114) (SAP 114) (SF3a120).

TFP11_MOUSE
θ value	6.88961 (rank : 76)	NC score	0.009318 (rank : 92)
Query Neighborhood Hits	77	Target Neighborhood Hits	95	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ERA6, Q8VD06	Gene names	Tfip11, Tip39
Domain Architecture
Description	Tuftelin-interacting protein 11 (Tuftelin-interacting protein 39).

SIRT6_HUMAN
θ value	8.99809 (rank : 77)	NC score	0.008058 (rank : 93)
Query Neighborhood Hits	77	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N6T7, O75291, Q6IAF5, Q6PK99, Q8NCD2, Q9BSI5, Q9BWP3, Q9NRC7, Q9UQD1	Gene names	SIRT6, SIR2L6
Domain Architecture
Description	Mono-ADP-ribosyltransferase sirtuin-6 (EC 2.4.2.31) (SIR2-like protein 6).

CEND3_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.171173 (rank : 72)
Query Neighborhood Hits	77	Target Neighborhood Hits	275	Shared Neighborhood Hits	51
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CEND3_MOUSE
θ value	θ > 10 (rank : 79)	NC score	0.174855 (rank : 71)
Query Neighborhood Hits	77	Target Neighborhood Hits	228	Shared Neighborhood Hits	49
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CF155_HUMAN
θ value	θ > 10 (rank : 80)	NC score	0.066848 (rank : 77)
Query Neighborhood Hits	77	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H8W2, Q5TG13	Gene names	C6orf155
Domain Architecture	No domain graphic available
Description	Protein C6orf155.

CK024_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.056276 (rank : 83)
Query Neighborhood Hits	77	Target Neighborhood Hits	408	Shared Neighborhood Hits	7
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

CO039_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.055303 (rank : 85)
Query Neighborhood Hits	77	Target Neighborhood Hits	445	Shared Neighborhood Hits	9
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

MDC1_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.055651 (rank : 84)
Query Neighborhood Hits	77	Target Neighborhood Hits	1446	Shared Neighborhood Hits	23
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MDC1_MOUSE
θ value	θ > 10 (rank : 84)	NC score	0.059932 (rank : 79)
Query Neighborhood Hits	77	Target Neighborhood Hits	998	Shared Neighborhood Hits	14
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

NACAM_MOUSE
θ value	θ > 10 (rank : 85)	NC score	0.058816 (rank : 80)
Query Neighborhood Hits	77	Target Neighborhood Hits	1866	Shared Neighborhood Hits	26
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

P85B_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.058579 (rank : 81)
Query Neighborhood Hits	77	Target Neighborhood Hits	543	Shared Neighborhood Hits	21
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PRRT3_HUMAN
θ value	θ > 10 (rank : 87)	NC score	0.062739 (rank : 78)
Query Neighborhood Hits	77	Target Neighborhood Hits	998	Shared Neighborhood Hits	17
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

RBP1_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.228904 (rank : 60)
Query Neighborhood Hits	77	Target Neighborhood Hits	521	Shared Neighborhood Hits	49
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RBP1_MOUSE
θ value	θ > 10 (rank : 89)	NC score	0.234061 (rank : 59)
Query Neighborhood Hits	77	Target Neighborhood Hits	493	Shared Neighborhood Hits	49
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RHG12_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.300652 (rank : 41)
Query Neighborhood Hits	77	Target Neighborhood Hits	190	Shared Neighborhood Hits	50
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG18_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.272443 (rank : 53)
Query Neighborhood Hits	77	Target Neighborhood Hits	90	Shared Neighborhood Hits	49
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

RHG26_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.249449 (rank : 55)
Query Neighborhood Hits	77	Target Neighborhood Hits	281	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

SAC3_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.209137 (rank : 63)
Query Neighborhood Hits	77	Target Neighborhood Hits	21	Shared Neighborhood Hits	5
SwissProt Accessions	Q92562, Q53H49, Q5TCS6	Gene names	SAC3, KIAA0274
Domain Architecture
Description	SAC domain-containing protein 3.

SAC3_MOUSE
θ value	θ > 10 (rank : 94)	NC score	0.210571 (rank : 62)
Query Neighborhood Hits	77	Target Neighborhood Hits	22	Shared Neighborhood Hits	5
SwissProt Accessions	Q91WF7, Q6A092	Gene names	Sac3, Kiaa0274
Domain Architecture	No domain graphic available
Description	SAC domain-containing protein 3.

STA13_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.189633 (rank : 68)
Query Neighborhood Hits	77	Target Neighborhood Hits	89	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

STA13_MOUSE
θ value	θ > 10 (rank : 96)	NC score	0.184881 (rank : 69)
Query Neighborhood Hits	77	Target Neighborhood Hits	89	Shared Neighborhood Hits	47
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

STAR8_HUMAN
θ value	θ > 10 (rank : 97)	NC score	0.200359 (rank : 65)
Query Neighborhood Hits	77	Target Neighborhood Hits	216	Shared Neighborhood Hits	50
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STAR8_MOUSE
θ value	θ > 10 (rank : 98)	NC score	0.199576 (rank : 67)
Query Neighborhood Hits	77	Target Neighborhood Hits	101	Shared Neighborhood Hits	48
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

Hits sorted by NC score

OCRL_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	77	Target Neighborhood Hits	77	Shared Neighborhood Hits	77
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).

I5P2_HUMAN
NC score	0.975892 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	77	Target Neighborhood Hits	86	Shared Neighborhood Hits	58
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

SKIP_MOUSE
NC score	0.797671 (rank : 3)	θ value	7.52953e-39 (rank : 9)
Query Neighborhood Hits	77	Target Neighborhood Hits	18	Shared Neighborhood Hits	13
SwissProt Accessions	Q8C5L6, O09040	Gene names	Skip, Pps
Domain Architecture
Description	Skeletal muscle and kidney-enriched inositol phosphatase (EC 3.1.3.56).

SKIP_HUMAN
NC score	0.796797 (rank : 4)	θ value	2.05049e-36 (rank : 10)
Query Neighborhood Hits	77	Target Neighborhood Hits	16	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BT40, Q15733, Q9NPJ5, Q9P2R5	Gene names	SKIP, PPS
Domain Architecture
Description	Skeletal muscle and kidney-enriched inositol phosphatase (EC 3.1.3.56).

SYNJ2_MOUSE
NC score	0.773088 (rank : 5)	θ value	8.00737e-57 (rank : 4)
Query Neighborhood Hits	77	Target Neighborhood Hits	87	Shared Neighborhood Hits	13
SwissProt Accessions	Q9D2G5, O35404, O88399, O88400, O88401, O88402, O88403, O88404	Gene names	Synj2, Kiaa0348
Domain Architecture
Description	Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 2).

SYNJ2_HUMAN
NC score	0.766504 (rank : 6)	θ value	4.24587e-58 (rank : 3)
Query Neighborhood Hits	77	Target Neighborhood Hits	136	Shared Neighborhood Hits	14
SwissProt Accessions	O15056, Q5TA13, Q5TA16, Q5TA19, Q86XK0, Q8IZA8, Q9H226	Gene names	SYNJ2, KIAA0348
Domain Architecture	No domain graphic available
Description	Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 2).

PI5PA_MOUSE
NC score	0.735614 (rank : 7)	θ value	5.95217e-44 (rank : 8)
Query Neighborhood Hits	77	Target Neighborhood Hits	331	Shared Neighborhood Hits	19
SwissProt Accessions	P59644	Gene names	Pib5pa
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

INP5E_MOUSE
NC score	0.734694 (rank : 8)	θ value	5.59698e-26 (rank : 11)
Query Neighborhood Hits	77	Target Neighborhood Hits	59	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JII1, Q3TCC9	Gene names	Inpp5e
Domain Architecture
Description	72 kDa inositol polyphosphate 5-phosphatase (EC 3.1.3.36) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (Phosphatidylinositol polyphosphate 5-phosphatase type IV).

INP5E_HUMAN
NC score	0.711803 (rank : 9)	θ value	9.54697e-26 (rank : 12)
Query Neighborhood Hits	77	Target Neighborhood Hits	201	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NRR6, Q15734	Gene names	INPP5E
Domain Architecture
Description	72 kDa inositol polyphosphate 5-phosphatase (EC 3.1.3.36) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (Phosphatidylinositol polyphosphate 5-phosphatase type IV).

SYNJ1_HUMAN
NC score	0.703498 (rank : 10)	θ value	5.37103e-53 (rank : 6)
Query Neighborhood Hits	77	Target Neighborhood Hits	498	Shared Neighborhood Hits	21
SwissProt Accessions	O43426, O43425, O94984	Gene names	SYNJ1, KIAA0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

SYNJ1_MOUSE
NC score	0.702311 (rank : 11)	θ value	4.85792e-54 (rank : 5)
Query Neighborhood Hits	77	Target Neighborhood Hits	516	Shared Neighborhood Hits	17
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

PI5PA_HUMAN
NC score	0.664747 (rank : 12)	θ value	5.95217e-44 (rank : 7)
Query Neighborhood Hits	77	Target Neighborhood Hits	749	Shared Neighborhood Hits	18
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

RHG08_HUMAN
NC score	0.384201 (rank : 13)	θ value	6.21693e-09 (rank : 13)
Query Neighborhood Hits	77	Target Neighborhood Hits	88	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NSG0, O75983, O95695, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NVX8, Q9NXL1, Q9UH20	Gene names	ARHGAP8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

RHG08_MOUSE
NC score	0.381499 (rank : 14)	θ value	5.26297e-08 (rank : 14)
Query Neighborhood Hits	77	Target Neighborhood Hits	73	Shared Neighborhood Hits	51
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

RHG25_MOUSE
NC score	0.364365 (rank : 15)	θ value	8.97725e-08 (rank : 15)
Query Neighborhood Hits	77	Target Neighborhood Hits	492	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

3BP1_HUMAN
NC score	0.362415 (rank : 16)	θ value	3.77169e-06 (rank : 20)
Query Neighborhood Hits	77	Target Neighborhood Hits	376	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

RHG01_HUMAN
NC score	0.360911 (rank : 17)	θ value	2.44474e-05 (rank : 27)
Query Neighborhood Hits	77	Target Neighborhood Hits	75	Shared Neighborhood Hits	51
SwissProt Accessions	Q07960	Gene names	ARHGAP1, CDC42GAP, RHOGAP1
Domain Architecture
Description	Rho-GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (CDC42 GTPase-activating protein) (p50-RhoGAP).

GMIP_HUMAN
NC score	0.360686 (rank : 18)	θ value	4.92598e-06 (rank : 21)
Query Neighborhood Hits	77	Target Neighborhood Hits	225	Shared Neighborhood Hits	52
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

3BP1_MOUSE
NC score	0.354510 (rank : 19)	θ value	5.44631e-05 (rank : 29)
Query Neighborhood Hits	77	Target Neighborhood Hits	238	Shared Neighborhood Hits	52
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

GMIP_MOUSE
NC score	0.352211 (rank : 20)	θ value	2.44474e-05 (rank : 26)
Query Neighborhood Hits	77	Target Neighborhood Hits	202	Shared Neighborhood Hits	51
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

RHG25_HUMAN
NC score	0.346680 (rank : 21)	θ value	3.41135e-07 (rank : 17)
Query Neighborhood Hits	77	Target Neighborhood Hits	550	Shared Neighborhood Hits	49
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG06_HUMAN
NC score	0.344616 (rank : 22)	θ value	8.40245e-06 (rank : 22)
Query Neighborhood Hits	77	Target Neighborhood Hits	114	Shared Neighborhood Hits	51
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

CHIO_MOUSE
NC score	0.344269 (rank : 23)	θ value	4.45536e-07 (rank : 18)
Query Neighborhood Hits	77	Target Neighborhood Hits	130	Shared Neighborhood Hits	50
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

RHG06_MOUSE
NC score	0.340490 (rank : 24)	θ value	1.43324e-05 (rank : 25)
Query Neighborhood Hits	77	Target Neighborhood Hits	105	Shared Neighborhood Hits	51
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

CHIO_HUMAN
NC score	0.332259 (rank : 25)	θ value	1.53129e-07 (rank : 16)
Query Neighborhood Hits	77	Target Neighborhood Hits	220	Shared Neighborhood Hits	50
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

TCGAP_MOUSE
NC score	0.331420 (rank : 26)	θ value	9.29e-05 (rank : 35)
Query Neighborhood Hits	77	Target Neighborhood Hits	409	Shared Neighborhood Hits	55
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

RHG12_MOUSE
NC score	0.323485 (rank : 27)	θ value	9.29e-05 (rank : 33)
Query Neighborhood Hits	77	Target Neighborhood Hits	204	Shared Neighborhood Hits	51
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

CHIN_HUMAN
NC score	0.323130 (rank : 28)	θ value	1.09739e-05 (rank : 24)
Query Neighborhood Hits	77	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

RHG09_HUMAN
NC score	0.322843 (rank : 29)	θ value	0.0563607 (rank : 54)
Query Neighborhood Hits	77	Target Neighborhood Hits	186	Shared Neighborhood Hits	52
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

CHIN_MOUSE
NC score	0.322177 (rank : 30)	θ value	4.1701e-05 (rank : 28)
Query Neighborhood Hits	77	Target Neighborhood Hits	229	Shared Neighborhood Hits	51
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

SRGP2_HUMAN
NC score	0.321228 (rank : 31)	θ value	2.88788e-06 (rank : 19)
Query Neighborhood Hits	77	Target Neighborhood Hits	331	Shared Neighborhood Hits	51
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
NC score	0.317749 (rank : 32)	θ value	8.40245e-06 (rank : 23)
Query Neighborhood Hits	77	Target Neighborhood Hits	324	Shared Neighborhood Hits	52
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

RHG05_MOUSE
NC score	0.314315 (rank : 33)	θ value	0.000461057 (rank : 40)
Query Neighborhood Hits	77	Target Neighborhood Hits	165	Shared Neighborhood Hits	51
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

GRLF1_HUMAN
NC score	0.313967 (rank : 34)	θ value	0.0148317 (rank : 49)
Query Neighborhood Hits	77	Target Neighborhood Hits	167	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

FNBP2_HUMAN
NC score	0.311430 (rank : 35)	θ value	0.00102713 (rank : 42)
Query Neighborhood Hits	77	Target Neighborhood Hits	432	Shared Neighborhood Hits	52
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

SRGP1_HUMAN
NC score	0.306736 (rank : 36)	θ value	0.00020696 (rank : 39)
Query Neighborhood Hits	77	Target Neighborhood Hits	390	Shared Neighborhood Hits	51
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

RHG04_HUMAN
NC score	0.306221 (rank : 37)	θ value	0.0113563 (rank : 47)
Query Neighborhood Hits	77	Target Neighborhood Hits	307	Shared Neighborhood Hits	53
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RHG05_HUMAN
NC score	0.304501 (rank : 38)	θ value	0.000786445 (rank : 41)
Query Neighborhood Hits	77	Target Neighborhood Hits	158	Shared Neighborhood Hits	51
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

K1688_MOUSE
NC score	0.304116 (rank : 39)	θ value	0.000121331 (rank : 36)
Query Neighborhood Hits	77	Target Neighborhood Hits	188	Shared Neighborhood Hits	48
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

K1688_HUMAN
NC score	0.301858 (rank : 40)	θ value	0.000158464 (rank : 37)
Query Neighborhood Hits	77	Target Neighborhood Hits	217	Shared Neighborhood Hits	49
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

RHG12_HUMAN
NC score	0.300652 (rank : 41)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	77	Target Neighborhood Hits	190	Shared Neighborhood Hits	50
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

TCGAP_HUMAN
NC score	0.300028 (rank : 42)	θ value	9.29e-05 (rank : 34)
Query Neighborhood Hits	77	Target Neighborhood Hits	872	Shared Neighborhood Hits	58
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

RGAP1_MOUSE
NC score	0.286606 (rank : 43)	θ value	1.38821 (rank : 62)
Query Neighborhood Hits	77	Target Neighborhood Hits	185	Shared Neighborhood Hits	50
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

OPHN1_HUMAN
NC score	0.286167 (rank : 44)	θ value	0.0113563 (rank : 46)
Query Neighborhood Hits	77	Target Neighborhood Hits	161	Shared Neighborhood Hits	52
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

RHG18_MOUSE
NC score	0.284740 (rank : 45)	θ value	0.0431538 (rank : 52)
Query Neighborhood Hits	77	Target Neighborhood Hits	110	Shared Neighborhood Hits	50
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

ABR_HUMAN
NC score	0.284636 (rank : 46)	θ value	0.00665767 (rank : 44)
Query Neighborhood Hits	77	Target Neighborhood Hits	166	Shared Neighborhood Hits	51
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

OPHN1_MOUSE
NC score	0.283732 (rank : 47)	θ value	0.0252991 (rank : 51)
Query Neighborhood Hits	77	Target Neighborhood Hits	174	Shared Neighborhood Hits	51
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

RGAP1_HUMAN
NC score	0.283133 (rank : 48)	θ value	0.813845 (rank : 58)
Query Neighborhood Hits	77	Target Neighborhood Hits	189	Shared Neighborhood Hits	50
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

CE005_MOUSE
NC score	0.281637 (rank : 49)	θ value	0.00869519 (rank : 45)
Query Neighborhood Hits	77	Target Neighborhood Hits	238	Shared Neighborhood Hits	50
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

BCR_HUMAN
NC score	0.281142 (rank : 50)	θ value	0.0252991 (rank : 50)
Query Neighborhood Hits	77	Target Neighborhood Hits	204	Shared Neighborhood Hits	51
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

CE005_HUMAN
NC score	0.280779 (rank : 51)	θ value	0.0148317 (rank : 48)
Query Neighborhood Hits	77	Target Neighborhood Hits	213	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

TAGAP_MOUSE
NC score	0.273566 (rank : 52)	θ value	1.06291 (rank : 60)
Query Neighborhood Hits	77	Target Neighborhood Hits	83	Shared Neighborhood Hits	49
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

RHG18_HUMAN
NC score	0.272443 (rank : 53)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	77	Target Neighborhood Hits	90	Shared Neighborhood Hits	49
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

TAGAP_HUMAN
NC score	0.268461 (rank : 54)	θ value	1.38821 (rank : 63)
Query Neighborhood Hits	77	Target Neighborhood Hits	82	Shared Neighborhood Hits	48
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

RHG26_HUMAN
NC score	0.249449 (rank : 55)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	77	Target Neighborhood Hits	281	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

I5P1_HUMAN
NC score	0.246273 (rank : 56)	θ value	7.1131e-05 (rank : 31)
Query Neighborhood Hits	77	Target Neighborhood Hits	15	Shared Neighborhood Hits	12
SwissProt Accessions	Q14642, Q14640	Gene names	INPP5A
Domain Architecture
Description	Type I inositol-1,4,5-trisphosphate 5-phosphatase (EC 3.1.3.56) (5PTase).

RHG07_MOUSE
NC score	0.235138 (rank : 57)	θ value	0.21417 (rank : 56)
Query Neighborhood Hits	77	Target Neighborhood Hits	103	Shared Neighborhood Hits	51
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

RHG07_HUMAN
NC score	0.234698 (rank : 58)	θ value	0.0563607 (rank : 53)
Query Neighborhood Hits	77	Target Neighborhood Hits	108	Shared Neighborhood Hits	51
SwissProt Accessions	Q96QB1, O14868, O43199, Q9C0E0	Gene names	DLC1, ARHGAP7, KIAA1723, STARD12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

RBP1_MOUSE
NC score	0.234061 (rank : 59)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	77	Target Neighborhood Hits	493	Shared Neighborhood Hits	49
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RBP1_HUMAN
NC score	0.228904 (rank : 60)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	77	Target Neighborhood Hits	521	Shared Neighborhood Hits	49
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

CEND2_HUMAN
NC score	0.212646 (rank : 61)	θ value	0.163984 (rank : 55)
Query Neighborhood Hits	77	Target Neighborhood Hits	166	Shared Neighborhood Hits	49
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

SAC3_MOUSE
NC score	0.210571 (rank : 62)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	77	Target Neighborhood Hits	22	Shared Neighborhood Hits	5
SwissProt Accessions	Q91WF7, Q6A092	Gene names	Sac3, Kiaa0274
Domain Architecture	No domain graphic available
Description	SAC domain-containing protein 3.

SAC3_HUMAN
NC score	0.209137 (rank : 63)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	77	Target Neighborhood Hits	21	Shared Neighborhood Hits	5
SwissProt Accessions	Q92562, Q53H49, Q5TCS6	Gene names	SAC3, KIAA0274
Domain Architecture
Description	SAC domain-containing protein 3.

P85A_MOUSE
NC score	0.201868 (rank : 64)	θ value	9.29e-05 (rank : 32)
Query Neighborhood Hits	77	Target Neighborhood Hits	435	Shared Neighborhood Hits	50
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

STAR8_HUMAN
NC score	0.200359 (rank : 65)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	77	Target Neighborhood Hits	216	Shared Neighborhood Hits	50
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

P85A_HUMAN
NC score	0.199835 (rank : 66)	θ value	0.00020696 (rank : 38)
Query Neighborhood Hits	77	Target Neighborhood Hits	479	Shared Neighborhood Hits	49
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

STAR8_MOUSE
NC score	0.199576 (rank : 67)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	77	Target Neighborhood Hits	101	Shared Neighborhood Hits	48
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STA13_HUMAN
NC score	0.189633 (rank : 68)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	77	Target Neighborhood Hits	89	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

STA13_MOUSE
NC score	0.184881 (rank : 69)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	77	Target Neighborhood Hits	89	Shared Neighborhood Hits	47
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

MYO9B_HUMAN
NC score	0.177514 (rank : 70)	θ value	5.44631e-05 (rank : 30)
Query Neighborhood Hits	77	Target Neighborhood Hits	641	Shared Neighborhood Hits	56
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

CEND3_MOUSE
NC score	0.174855 (rank : 71)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	77	Target Neighborhood Hits	228	Shared Neighborhood Hits	49
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CEND3_HUMAN
NC score	0.171173 (rank : 72)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	77	Target Neighborhood Hits	275	Shared Neighborhood Hits	51
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

MYO9B_MOUSE
NC score	0.169966 (rank : 73)	θ value	0.00102713 (rank : 43)
Query Neighborhood Hits	77	Target Neighborhood Hits	311	Shared Neighborhood Hits	52
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

CEND1_MOUSE
NC score	0.166663 (rank : 74)	θ value	4.03905 (rank : 65)
Query Neighborhood Hits	77	Target Neighborhood Hits	260	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CEND1_HUMAN
NC score	0.159616 (rank : 75)	θ value	2.36792 (rank : 64)
Query Neighborhood Hits	77	Target Neighborhood Hits	284	Shared Neighborhood Hits	47
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

PROL4_HUMAN
NC score	0.076271 (rank : 76)	θ value	0.47712 (rank : 57)
Query Neighborhood Hits	77	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	Q16378, Q8NFB3	Gene names	PRR4, LPRP, PROL4
Domain Architecture	No domain graphic available
Description	Proline-rich protein 4 precursor (Lacrimal proline-rich protein) (Nasopharyngeal carcinoma-associated proline-rich protein 4).

CF155_HUMAN
NC score	0.066848 (rank : 77)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	77	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H8W2, Q5TG13	Gene names	C6orf155
Domain Architecture	No domain graphic available
Description	Protein C6orf155.

PRRT3_HUMAN
NC score	0.062739 (rank : 78)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	77	Target Neighborhood Hits	998	Shared Neighborhood Hits	17
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

MDC1_MOUSE
NC score	0.059932 (rank : 79)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	77	Target Neighborhood Hits	998	Shared Neighborhood Hits	14
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

NACAM_MOUSE
NC score	0.058816 (rank : 80)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	77	Target Neighborhood Hits	1866	Shared Neighborhood Hits	26
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

P85B_HUMAN
NC score	0.058579 (rank : 81)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	77	Target Neighborhood Hits	543	Shared Neighborhood Hits	21
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

OGFR_HUMAN
NC score	0.056734 (rank : 82)	θ value	1.38821 (rank : 61)
Query Neighborhood Hits	77	Target Neighborhood Hits	1582	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

CK024_HUMAN
NC score	0.056276 (rank : 83)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	77	Target Neighborhood Hits	408	Shared Neighborhood Hits	7
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

MDC1_HUMAN
NC score	0.055651 (rank : 84)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	77	Target Neighborhood Hits	1446	Shared Neighborhood Hits	23
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

CO039_MOUSE
NC score	0.055303 (rank : 85)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	77	Target Neighborhood Hits	445	Shared Neighborhood Hits	9
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

SF3A1_MOUSE
NC score	0.031958 (rank : 86)	θ value	0.813845 (rank : 59)
Query Neighborhood Hits	77	Target Neighborhood Hits	198	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K4Z5, Q8C0M7, Q8C128, Q8C175, Q921T3	Gene names	Sf3a1
Domain Architecture	No domain graphic available
Description	Splicing factor 3 subunit 1 (SF3a120).

SF3A1_HUMAN
NC score	0.023988 (rank : 87)	θ value	6.88961 (rank : 75)
Query Neighborhood Hits	77	Target Neighborhood Hits	199	Shared Neighborhood Hits	6
SwissProt Accessions	Q15459	Gene names	SF3A1, SAP114
Domain Architecture
Description	Splicing factor 3 subunit 1 (Spliceosome-associated protein 114) (SAP 114) (SF3a120).

NCOR1_HUMAN
NC score	0.015466 (rank : 88)	θ value	5.27518 (rank : 71)
Query Neighborhood Hits	77	Target Neighborhood Hits	577	Shared Neighborhood Hits	9
SwissProt Accessions	O75376, Q9UPV5, Q9UQ18	Gene names	NCOR1, KIAA1047
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR).

I27RA_HUMAN
NC score	0.013485 (rank : 89)	θ value	4.03905 (rank : 66)
Query Neighborhood Hits	77	Target Neighborhood Hits	60	Shared Neighborhood Hits	2
SwissProt Accessions	Q6UWB1, O60624	Gene names	IL27RA, CRL1, TCCR, WSX1
Domain Architecture	No domain graphic available
Description	Interleukin-27 receptor alpha chain precursor (IL-27R-alpha) (WSX-1) (Type I T-cell cytokine receptor) (TCCR) (Protein CRL1).

MS3L1_MOUSE
NC score	0.011702 (rank : 90)	θ value	6.88961 (rank : 73)
Query Neighborhood Hits	77	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WVG9	Gene names	Msl3l1, Msl31
Domain Architecture
Description	Male-specific lethal 3-like 1 (MSL3-like 1) (Male-specific lethal-3 homolog 1).

RRMJ3_MOUSE
NC score	0.009551 (rank : 91)	θ value	6.88961 (rank : 74)
Query Neighborhood Hits	77	Target Neighborhood Hits	163	Shared Neighborhood Hits	2
SwissProt Accessions	Q9DBE9, Q3ULI1, Q921I7	Gene names	Ftsj3
Domain Architecture	No domain graphic available
Description	Putative rRNA methyltransferase 3 (EC 2.1.1.-) (rRNA (uridine-2'-O-)- methyltransferase 3).

TFP11_MOUSE
NC score	0.009318 (rank : 92)	θ value	6.88961 (rank : 76)
Query Neighborhood Hits	77	Target Neighborhood Hits	95	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ERA6, Q8VD06	Gene names	Tfip11, Tip39
Domain Architecture
Description	Tuftelin-interacting protein 11 (Tuftelin-interacting protein 39).

SIRT6_HUMAN
NC score	0.008058 (rank : 93)	θ value	8.99809 (rank : 77)
Query Neighborhood Hits	77	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N6T7, O75291, Q6IAF5, Q6PK99, Q8NCD2, Q9BSI5, Q9BWP3, Q9NRC7, Q9UQD1	Gene names	SIRT6, SIR2L6
Domain Architecture
Description	Mono-ADP-ribosyltransferase sirtuin-6 (EC 2.4.2.31) (SIR2-like protein 6).

HXB4_MOUSE
NC score	0.004311 (rank : 94)	θ value	5.27518 (rank : 70)
Query Neighborhood Hits	77	Target Neighborhood Hits	375	Shared Neighborhood Hits	6
SwissProt Accessions	P10284, Q3UZB4, Q4VBG0	Gene names	Hoxb4, Hox-2.6, Hoxb-4
Domain Architecture
Description	Homeobox protein Hox-B4 (Hox-2.6).

HXB4_HUMAN
NC score	0.003925 (rank : 95)	θ value	5.27518 (rank : 69)
Query Neighborhood Hits	77	Target Neighborhood Hits	376	Shared Neighborhood Hits	5
SwissProt Accessions	P17483, Q9NTA0	Gene names	HOXB4, HOX2F
Domain Architecture
Description	Homeobox protein Hox-B4 (Hox-2F) (Hox-2.6).

ANR25_HUMAN
NC score	0.003858 (rank : 96)	θ value	6.88961 (rank : 72)
Query Neighborhood Hits	77	Target Neighborhood Hits	350	Shared Neighborhood Hits	4
SwissProt Accessions	Q63ZY3, Q3KQZ3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210	Gene names	ANKRD25, KIAA1518, SIP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25 (SRC-1-interacting protein) (SRC1-interacting protein).

ANK3_HUMAN
NC score	0.001669 (rank : 97)	θ value	5.27518 (rank : 68)
Query Neighborhood Hits	77	Target Neighborhood Hits	853	Shared Neighborhood Hits	5
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

LATS1_HUMAN
NC score	-0.002308 (rank : 98)	θ value	4.03905 (rank : 67)
Query Neighborhood Hits	77	Target Neighborhood Hits	1057	Shared Neighborhood Hits	4
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).