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Network neighborhood for query Sequence : CEND3_HUMAN

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CEND3_HUMAN
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CEND1_HUMAN
θ value	0 (rank : 1)	NC score	0.937539 (rank : 5)
Query Neighborhood Hits	275	Target Neighborhood Hits	284	Shared Neighborhood Hits	144
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CEND1_MOUSE
θ value	0 (rank : 2)	NC score	0.942897 (rank : 4)
Query Neighborhood Hits	275	Target Neighborhood Hits	260	Shared Neighborhood Hits	136
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CEND2_HUMAN
θ value	0 (rank : 3)	NC score	0.947031 (rank : 3)
Query Neighborhood Hits	275	Target Neighborhood Hits	166	Shared Neighborhood Hits	112
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

CEND3_HUMAN
θ value	0 (rank : 4)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	275	Target Neighborhood Hits	275	Shared Neighborhood Hits	275
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CEND3_MOUSE
θ value	0 (rank : 5)	NC score	0.988977 (rank : 2)
Query Neighborhood Hits	275	Target Neighborhood Hits	228	Shared Neighborhood Hits	184
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

DDFL1_HUMAN
θ value	8.65492e-19 (rank : 6)	NC score	0.515320 (rank : 46)
Query Neighborhood Hits	275	Target Neighborhood Hits	353	Shared Neighborhood Hits	62
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

CENG3_HUMAN
θ value	1.92812e-18 (rank : 7)	NC score	0.471707 (rank : 71)
Query Neighborhood Hits	275	Target Neighborhood Hits	455	Shared Neighborhood Hits	50
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

DDFL1_MOUSE
θ value	3.28887e-18 (rank : 8)	NC score	0.492531 (rank : 55)
Query Neighborhood Hits	275	Target Neighborhood Hits	324	Shared Neighborhood Hits	59
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

CENG3_MOUSE
θ value	4.29542e-18 (rank : 9)	NC score	0.471534 (rank : 72)
Query Neighborhood Hits	275	Target Neighborhood Hits	467	Shared Neighborhood Hits	49
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG1_MOUSE
θ value	9.56915e-18 (rank : 10)	NC score	0.488365 (rank : 56)
Query Neighborhood Hits	275	Target Neighborhood Hits	531	Shared Neighborhood Hits	71
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

MYO9B_MOUSE
θ value	9.56915e-18 (rank : 11)	NC score	0.323795 (rank : 87)
Query Neighborhood Hits	275	Target Neighborhood Hits	311	Shared Neighborhood Hits	70
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

CENG1_HUMAN
θ value	1.24977e-17 (rank : 12)	NC score	0.482573 (rank : 63)
Query Neighborhood Hits	275	Target Neighborhood Hits	544	Shared Neighborhood Hits	69
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

MYO9B_HUMAN
θ value	1.24977e-17 (rank : 13)	NC score	0.323301 (rank : 88)
Query Neighborhood Hits	275	Target Neighborhood Hits	641	Shared Neighborhood Hits	92
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

TCGAP_HUMAN
θ value	2.7842e-17 (rank : 14)	NC score	0.514406 (rank : 47)
Query Neighborhood Hits	275	Target Neighborhood Hits	872	Shared Neighborhood Hits	107
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	2.7842e-17 (rank : 15)	NC score	0.565304 (rank : 24)
Query Neighborhood Hits	275	Target Neighborhood Hits	409	Shared Neighborhood Hits	88
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

CENB5_HUMAN
θ value	1.058e-16 (rank : 16)	NC score	0.484943 (rank : 59)
Query Neighborhood Hits	275	Target Neighborhood Hits	395	Shared Neighborhood Hits	70
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CENG2_MOUSE
θ value	1.058e-16 (rank : 17)	NC score	0.450313 (rank : 76)
Query Neighborhood Hits	275	Target Neighborhood Hits	463	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

CENB2_HUMAN
θ value	1.80466e-16 (rank : 18)	NC score	0.481171 (rank : 65)
Query Neighborhood Hits	275	Target Neighborhood Hits	425	Shared Neighborhood Hits	75
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENG2_HUMAN
θ value	1.80466e-16 (rank : 19)	NC score	0.448116 (rank : 77)
Query Neighborhood Hits	275	Target Neighborhood Hits	471	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

RHG05_MOUSE
θ value	6.85773e-16 (rank : 20)	NC score	0.570062 (rank : 19)
Query Neighborhood Hits	275	Target Neighborhood Hits	165	Shared Neighborhood Hits	60
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

DDEF2_HUMAN
θ value	1.99529e-15 (rank : 21)	NC score	0.476871 (rank : 67)
Query Neighborhood Hits	275	Target Neighborhood Hits	599	Shared Neighborhood Hits	82
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

RHG09_HUMAN
θ value	1.99529e-15 (rank : 22)	NC score	0.617545 (rank : 6)
Query Neighborhood Hits	275	Target Neighborhood Hits	186	Shared Neighborhood Hits	67
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

RHG05_HUMAN
θ value	3.40345e-15 (rank : 23)	NC score	0.565391 (rank : 23)
Query Neighborhood Hits	275	Target Neighborhood Hits	158	Shared Neighborhood Hits	60
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

DDEF1_MOUSE
θ value	4.44505e-15 (rank : 24)	NC score	0.482284 (rank : 64)
Query Neighborhood Hits	275	Target Neighborhood Hits	592	Shared Neighborhood Hits	75
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_MOUSE
θ value	4.44505e-15 (rank : 25)	NC score	0.473795 (rank : 69)
Query Neighborhood Hits	275	Target Neighborhood Hits	625	Shared Neighborhood Hits	86
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

GRLF1_HUMAN
θ value	1.29331e-14 (rank : 26)	NC score	0.583936 (rank : 13)
Query Neighborhood Hits	275	Target Neighborhood Hits	167	Shared Neighborhood Hits	68
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

SMP1L_HUMAN
θ value	4.91457e-14 (rank : 27)	NC score	0.566456 (rank : 21)
Query Neighborhood Hits	275	Target Neighborhood Hits	74	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

SMP1L_MOUSE
θ value	4.91457e-14 (rank : 28)	NC score	0.565810 (rank : 22)
Query Neighborhood Hits	275	Target Neighborhood Hits	70	Shared Neighborhood Hits	39
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

CENB1_HUMAN
θ value	6.41864e-14 (rank : 29)	NC score	0.483365 (rank : 61)
Query Neighborhood Hits	275	Target Neighborhood Hits	383	Shared Neighborhood Hits	72
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

BCR_HUMAN
θ value	1.86753e-13 (rank : 30)	NC score	0.526540 (rank : 36)
Query Neighborhood Hits	275	Target Neighborhood Hits	204	Shared Neighborhood Hits	72
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ABR_HUMAN
θ value	4.16044e-13 (rank : 31)	NC score	0.536194 (rank : 33)
Query Neighborhood Hits	275	Target Neighborhood Hits	166	Shared Neighborhood Hits	66
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

RHG07_MOUSE
θ value	4.16044e-13 (rank : 32)	NC score	0.511864 (rank : 48)
Query Neighborhood Hits	275	Target Neighborhood Hits	103	Shared Neighborhood Hits	62
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

RHG12_HUMAN
θ value	4.16044e-13 (rank : 33)	NC score	0.577671 (rank : 16)
Query Neighborhood Hits	275	Target Neighborhood Hits	190	Shared Neighborhood Hits	63
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	5.43371e-13 (rank : 34)	NC score	0.576511 (rank : 17)
Query Neighborhood Hits	275	Target Neighborhood Hits	204	Shared Neighborhood Hits	66
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

GMIP_MOUSE
θ value	1.2105e-12 (rank : 35)	NC score	0.588717 (rank : 8)
Query Neighborhood Hits	275	Target Neighborhood Hits	202	Shared Neighborhood Hits	66
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

RHG06_MOUSE
θ value	1.2105e-12 (rank : 36)	NC score	0.586293 (rank : 11)
Query Neighborhood Hits	275	Target Neighborhood Hits	105	Shared Neighborhood Hits	61
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RGAP1_HUMAN
θ value	1.58096e-12 (rank : 37)	NC score	0.586761 (rank : 10)
Query Neighborhood Hits	275	Target Neighborhood Hits	189	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RHG06_HUMAN
θ value	1.58096e-12 (rank : 38)	NC score	0.587288 (rank : 9)
Query Neighborhood Hits	275	Target Neighborhood Hits	114	Shared Neighborhood Hits	65
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG07_HUMAN
θ value	1.58096e-12 (rank : 39)	NC score	0.506087 (rank : 52)
Query Neighborhood Hits	275	Target Neighborhood Hits	108	Shared Neighborhood Hits	60
SwissProt Accessions	Q96QB1, O14868, O43199, Q9C0E0	Gene names	DLC1, ARHGAP7, KIAA1723, STARD12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

RHG18_HUMAN
θ value	2.69671e-12 (rank : 40)	NC score	0.578270 (rank : 15)
Query Neighborhood Hits	275	Target Neighborhood Hits	90	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

SMAP1_HUMAN
θ value	2.69671e-12 (rank : 41)	NC score	0.561820 (rank : 26)
Query Neighborhood Hits	275	Target Neighborhood Hits	98	Shared Neighborhood Hits	46
SwissProt Accessions	Q8IYB5, Q53H70, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4	Gene names	SMAP1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMAP1_MOUSE
θ value	2.69671e-12 (rank : 42)	NC score	0.563424 (rank : 25)
Query Neighborhood Hits	275	Target Neighborhood Hits	120	Shared Neighborhood Hits	49
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

CHIN_MOUSE
θ value	3.52202e-12 (rank : 43)	NC score	0.527883 (rank : 35)
Query Neighborhood Hits	275	Target Neighborhood Hits	229	Shared Neighborhood Hits	66
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_MOUSE
θ value	3.52202e-12 (rank : 44)	NC score	0.548941 (rank : 31)
Query Neighborhood Hits	275	Target Neighborhood Hits	130	Shared Neighborhood Hits	61
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIN_HUMAN
θ value	6.00763e-12 (rank : 45)	NC score	0.526247 (rank : 37)
Query Neighborhood Hits	275	Target Neighborhood Hits	227	Shared Neighborhood Hits	65
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	6.00763e-12 (rank : 46)	NC score	0.524247 (rank : 39)
Query Neighborhood Hits	275	Target Neighborhood Hits	220	Shared Neighborhood Hits	65
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

GIT2_MOUSE
θ value	1.02475e-11 (rank : 47)	NC score	0.438639 (rank : 79)
Query Neighborhood Hits	275	Target Neighborhood Hits	323	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

RBP1_MOUSE
θ value	1.02475e-11 (rank : 48)	NC score	0.537532 (rank : 32)
Query Neighborhood Hits	275	Target Neighborhood Hits	493	Shared Neighborhood Hits	70
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

GIT2_HUMAN
θ value	2.28291e-11 (rank : 49)	NC score	0.438674 (rank : 78)
Query Neighborhood Hits	275	Target Neighborhood Hits	381	Shared Neighborhood Hits	47
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

GMIP_HUMAN
θ value	2.28291e-11 (rank : 50)	NC score	0.575396 (rank : 18)
Query Neighborhood Hits	275	Target Neighborhood Hits	225	Shared Neighborhood Hits	68
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

OPHN1_MOUSE
θ value	3.89403e-11 (rank : 51)	NC score	0.592279 (rank : 7)
Query Neighborhood Hits	275	Target Neighborhood Hits	174	Shared Neighborhood Hits	71
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

CENA1_HUMAN
θ value	5.08577e-11 (rank : 52)	NC score	0.556922 (rank : 29)
Query Neighborhood Hits	275	Target Neighborhood Hits	87	Shared Neighborhood Hits	60
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

FNBP2_HUMAN
θ value	8.67504e-11 (rank : 53)	NC score	0.483956 (rank : 60)
Query Neighborhood Hits	275	Target Neighborhood Hits	432	Shared Neighborhood Hits	74
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

RBP1_HUMAN
θ value	8.67504e-11 (rank : 54)	NC score	0.523290 (rank : 40)
Query Neighborhood Hits	275	Target Neighborhood Hits	521	Shared Neighborhood Hits	70
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RHG04_HUMAN
θ value	8.67504e-11 (rank : 55)	NC score	0.511458 (rank : 49)
Query Neighborhood Hits	275	Target Neighborhood Hits	307	Shared Neighborhood Hits	67
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RGAP1_MOUSE
θ value	1.133e-10 (rank : 56)	NC score	0.584230 (rank : 12)
Query Neighborhood Hits	275	Target Neighborhood Hits	185	Shared Neighborhood Hits	61
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

3BP1_HUMAN
θ value	1.47974e-10 (rank : 57)	NC score	0.557397 (rank : 28)
Query Neighborhood Hits	275	Target Neighborhood Hits	376	Shared Neighborhood Hits	101
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

OPHN1_HUMAN
θ value	1.9326e-10 (rank : 58)	NC score	0.582512 (rank : 14)
Query Neighborhood Hits	275	Target Neighborhood Hits	161	Shared Neighborhood Hits	69
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

RHG18_MOUSE
θ value	2.52405e-10 (rank : 59)	NC score	0.569126 (rank : 20)
Query Neighborhood Hits	275	Target Neighborhood Hits	110	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

CENA2_HUMAN
θ value	4.30538e-10 (rank : 60)	NC score	0.531497 (rank : 34)
Query Neighborhood Hits	275	Target Neighborhood Hits	83	Shared Neighborhood Hits	57
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

ARFG3_MOUSE
θ value	5.62301e-10 (rank : 61)	NC score	0.520161 (rank : 43)
Query Neighborhood Hits	275	Target Neighborhood Hits	80	Shared Neighborhood Hits	38
SwissProt Accessions	Q9D8S3, Q99KN8	Gene names	Arfgap3
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

STA13_MOUSE
θ value	5.62301e-10 (rank : 62)	NC score	0.473536 (rank : 70)
Query Neighborhood Hits	275	Target Neighborhood Hits	89	Shared Neighborhood Hits	58
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

GIT1_HUMAN
θ value	7.34386e-10 (rank : 63)	NC score	0.425967 (rank : 80)
Query Neighborhood Hits	275	Target Neighborhood Hits	336	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

GIT1_MOUSE
θ value	7.34386e-10 (rank : 64)	NC score	0.424584 (rank : 81)
Query Neighborhood Hits	275	Target Neighborhood Hits	341	Shared Neighborhood Hits	44
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

ARFG3_HUMAN
θ value	1.63604e-09 (rank : 65)	NC score	0.521030 (rank : 42)
Query Neighborhood Hits	275	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

STA13_HUMAN
θ value	1.63604e-09 (rank : 66)	NC score	0.475740 (rank : 68)
Query Neighborhood Hits	275	Target Neighborhood Hits	89	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

SRGP2_HUMAN
θ value	3.64472e-09 (rank : 67)	NC score	0.492778 (rank : 54)
Query Neighborhood Hits	275	Target Neighborhood Hits	331	Shared Neighborhood Hits	68
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

STAR8_MOUSE
θ value	3.64472e-09 (rank : 68)	NC score	0.464689 (rank : 74)
Query Neighborhood Hits	275	Target Neighborhood Hits	101	Shared Neighborhood Hits	58
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

3BP1_MOUSE
θ value	4.76016e-09 (rank : 69)	NC score	0.559918 (rank : 27)
Query Neighborhood Hits	275	Target Neighborhood Hits	238	Shared Neighborhood Hits	84
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

CENA2_MOUSE
θ value	4.76016e-09 (rank : 70)	NC score	0.524798 (rank : 38)
Query Neighborhood Hits	275	Target Neighborhood Hits	68	Shared Neighborhood Hits	53
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

STAR8_HUMAN
θ value	6.21693e-09 (rank : 71)	NC score	0.463130 (rank : 75)
Query Neighborhood Hits	275	Target Neighborhood Hits	216	Shared Neighborhood Hits	69
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

RHG26_HUMAN
θ value	1.38499e-08 (rank : 72)	NC score	0.549887 (rank : 30)
Query Neighborhood Hits	275	Target Neighborhood Hits	281	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

SRGP2_MOUSE
θ value	1.38499e-08 (rank : 73)	NC score	0.486230 (rank : 57)
Query Neighborhood Hits	275	Target Neighborhood Hits	324	Shared Neighborhood Hits	68
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

TAGAP_MOUSE
θ value	1.38499e-08 (rank : 74)	NC score	0.519215 (rank : 45)
Query Neighborhood Hits	275	Target Neighborhood Hits	83	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

SRGP1_HUMAN
θ value	4.0297e-08 (rank : 75)	NC score	0.481066 (rank : 66)
Query Neighborhood Hits	275	Target Neighborhood Hits	390	Shared Neighborhood Hits	70
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

ARFG1_MOUSE
θ value	2.61198e-07 (rank : 76)	NC score	0.507053 (rank : 51)
Query Neighborhood Hits	275	Target Neighborhood Hits	51	Shared Neighborhood Hits	39
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

RHG25_MOUSE
θ value	3.41135e-07 (rank : 77)	NC score	0.510373 (rank : 50)
Query Neighborhood Hits	275	Target Neighborhood Hits	492	Shared Neighborhood Hits	104
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

ARFG1_HUMAN
θ value	5.81887e-07 (rank : 78)	NC score	0.494471 (rank : 53)
Query Neighborhood Hits	275	Target Neighborhood Hits	60	Shared Neighborhood Hits	40
SwissProt Accessions	Q8N6T3, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0	Gene names	ARFGAP1, ARF1GAP
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

RHG25_HUMAN
θ value	5.81887e-07 (rank : 79)	NC score	0.470805 (rank : 73)
Query Neighborhood Hits	275	Target Neighborhood Hits	550	Shared Neighborhood Hits	100
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

TAGAP_HUMAN
θ value	2.21117e-06 (rank : 80)	NC score	0.522756 (rank : 41)
Query Neighborhood Hits	275	Target Neighborhood Hits	82	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

RHG01_HUMAN
θ value	4.92598e-06 (rank : 81)	NC score	0.519559 (rank : 44)
Query Neighborhood Hits	275	Target Neighborhood Hits	75	Shared Neighborhood Hits	60
SwissProt Accessions	Q07960	Gene names	ARHGAP1, CDC42GAP, RHOGAP1
Domain Architecture
Description	Rho-GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (CDC42 GTPase-activating protein) (p50-RhoGAP).

NUPL_HUMAN
θ value	0.000121331 (rank : 82)	NC score	0.371707 (rank : 84)
Query Neighborhood Hits	275	Target Neighborhood Hits	68	Shared Neighborhood Hits	38
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).

NUPL_MOUSE
θ value	0.000121331 (rank : 83)	NC score	0.368250 (rank : 85)
Query Neighborhood Hits	275	Target Neighborhood Hits	113	Shared Neighborhood Hits	41
SwissProt Accessions	Q8K2K6, O70448, Q8BQL5, Q8CDK9	Gene names	Hrb, Rip
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein homolog).

PKHA1_HUMAN
θ value	0.000270298 (rank : 84)	NC score	0.224702 (rank : 94)
Query Neighborhood Hits	275	Target Neighborhood Hits	127	Shared Neighborhood Hits	48
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

EPHA8_MOUSE
θ value	0.00035302 (rank : 85)	NC score	0.068415 (rank : 143)
Query Neighborhood Hits	275	Target Neighborhood Hits	969	Shared Neighborhood Hits	48
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

RHG08_HUMAN
θ value	0.000461057 (rank : 86)	NC score	0.483054 (rank : 62)
Query Neighborhood Hits	275	Target Neighborhood Hits	88	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NSG0, O75983, O95695, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NVX8, Q9NXL1, Q9UH20	Gene names	ARHGAP8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

HRBL_HUMAN
θ value	0.000786445 (rank : 87)	NC score	0.329650 (rank : 86)
Query Neighborhood Hits	275	Target Neighborhood Hits	179	Shared Neighborhood Hits	55
SwissProt Accessions	O95081, O75429, Q96AB9, Q96GL4	Gene names	HRBL, RABR
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

HRBL_MOUSE
θ value	0.000786445 (rank : 88)	NC score	0.315839 (rank : 89)
Query Neighborhood Hits	275	Target Neighborhood Hits	269	Shared Neighborhood Hits	55
SwissProt Accessions	Q80WC7, Q8BKS5, Q99J67	Gene names	Hrbl, Rabr
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

PKHA1_MOUSE
θ value	0.000786445 (rank : 89)	NC score	0.217885 (rank : 95)
Query Neighborhood Hits	275	Target Neighborhood Hits	120	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

CE005_HUMAN
θ value	0.00102713 (rank : 90)	NC score	0.419789 (rank : 82)
Query Neighborhood Hits	275	Target Neighborhood Hits	213	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

EPHA1_MOUSE
θ value	0.00102713 (rank : 91)	NC score	0.068929 (rank : 141)
Query Neighborhood Hits	275	Target Neighborhood Hits	958	Shared Neighborhood Hits	48
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

RHG08_MOUSE
θ value	0.00102713 (rank : 92)	NC score	0.485125 (rank : 58)
Query Neighborhood Hits	275	Target Neighborhood Hits	73	Shared Neighborhood Hits	60
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

TNKS1_HUMAN
θ value	0.00102713 (rank : 93)	NC score	0.084343 (rank : 122)
Query Neighborhood Hits	275	Target Neighborhood Hits	477	Shared Neighborhood Hits	68
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

DGKH_HUMAN
θ value	0.00134147 (rank : 94)	NC score	0.133398 (rank : 102)
Query Neighborhood Hits	275	Target Neighborhood Hits	255	Shared Neighborhood Hits	71
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

EPHA8_HUMAN
θ value	0.00175202 (rank : 95)	NC score	0.066269 (rank : 149)
Query Neighborhood Hits	275	Target Neighborhood Hits	956	Shared Neighborhood Hits	46
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHA5_HUMAN
θ value	0.00228821 (rank : 96)	NC score	0.066244 (rank : 150)
Query Neighborhood Hits	275	Target Neighborhood Hits	1009	Shared Neighborhood Hits	53
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

PKHA2_MOUSE
θ value	0.00228821 (rank : 97)	NC score	0.185185 (rank : 96)
Query Neighborhood Hits	275	Target Neighborhood Hits	116	Shared Neighborhood Hits	41
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

EPHA1_HUMAN
θ value	0.00390308 (rank : 98)	NC score	0.066834 (rank : 146)
Query Neighborhood Hits	275	Target Neighborhood Hits	997	Shared Neighborhood Hits	44
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

P85A_HUMAN
θ value	0.00390308 (rank : 99)	NC score	0.273397 (rank : 92)
Query Neighborhood Hits	275	Target Neighborhood Hits	479	Shared Neighborhood Hits	68
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	0.00390308 (rank : 100)	NC score	0.267625 (rank : 93)
Query Neighborhood Hits	275	Target Neighborhood Hits	435	Shared Neighborhood Hits	68
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

EPHA7_HUMAN
θ value	0.00509761 (rank : 101)	NC score	0.065296 (rank : 153)
Query Neighborhood Hits	275	Target Neighborhood Hits	1053	Shared Neighborhood Hits	51
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

CSKI1_HUMAN
θ value	0.00665767 (rank : 102)	NC score	0.102880 (rank : 107)
Query Neighborhood Hits	275	Target Neighborhood Hits	997	Shared Neighborhood Hits	122
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

DGKD_HUMAN
θ value	0.00665767 (rank : 103)	NC score	0.117115 (rank : 103)
Query Neighborhood Hits	275	Target Neighborhood Hits	231	Shared Neighborhood Hits	60
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

CE005_MOUSE
θ value	0.00869519 (rank : 104)	NC score	0.415390 (rank : 83)
Query Neighborhood Hits	275	Target Neighborhood Hits	238	Shared Neighborhood Hits	63
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

EPHA4_HUMAN
θ value	0.0113563 (rank : 105)	NC score	0.069453 (rank : 138)
Query Neighborhood Hits	275	Target Neighborhood Hits	975	Shared Neighborhood Hits	47
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA7_MOUSE
θ value	0.0113563 (rank : 106)	NC score	0.064465 (rank : 157)
Query Neighborhood Hits	275	Target Neighborhood Hits	1025	Shared Neighborhood Hits	48
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHB1_HUMAN
θ value	0.0113563 (rank : 107)	NC score	0.063815 (rank : 160)
Query Neighborhood Hits	275	Target Neighborhood Hits	988	Shared Neighborhood Hits	49
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

MAST4_HUMAN
θ value	0.0113563 (rank : 108)	NC score	0.017616 (rank : 290)
Query Neighborhood Hits	275	Target Neighborhood Hits	1804	Shared Neighborhood Hits	103
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

TNKS2_HUMAN
θ value	0.0113563 (rank : 109)	NC score	0.075720 (rank : 131)
Query Neighborhood Hits	275	Target Neighborhood Hits	361	Shared Neighborhood Hits	40
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

BAT2_MOUSE
θ value	0.0148317 (rank : 110)	NC score	0.071582 (rank : 133)
Query Neighborhood Hits	275	Target Neighborhood Hits	947	Shared Neighborhood Hits	77
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

EPHA4_MOUSE
θ value	0.0193708 (rank : 111)	NC score	0.068105 (rank : 144)
Query Neighborhood Hits	275	Target Neighborhood Hits	982	Shared Neighborhood Hits	48
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

ZN406_HUMAN
θ value	0.0193708 (rank : 112)	NC score	-0.001553 (rank : 339)
Query Neighborhood Hits	275	Target Neighborhood Hits	794	Shared Neighborhood Hits	8
SwissProt Accessions	Q9P243, Q3MIM5, Q6PJ01, Q75PJ7, Q75PJ9, Q86X64	Gene names	ZNF406, KIAA1485
Domain Architecture	No domain graphic available
Description	Zinc finger protein 406 (Protein ZFAT).

EPHA6_HUMAN
θ value	0.0252991 (rank : 113)	NC score	0.070774 (rank : 135)
Query Neighborhood Hits	275	Target Neighborhood Hits	959	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA2_MOUSE
θ value	0.0330416 (rank : 114)	NC score	0.063395 (rank : 162)
Query Neighborhood Hits	275	Target Neighborhood Hits	1020	Shared Neighborhood Hits	48
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

PKHA6_MOUSE
θ value	0.0330416 (rank : 115)	NC score	0.161971 (rank : 99)
Query Neighborhood Hits	275	Target Neighborhood Hits	591	Shared Neighborhood Hits	68
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

TROAP_HUMAN
θ value	0.0330416 (rank : 116)	NC score	0.053192 (rank : 203)
Query Neighborhood Hits	275	Target Neighborhood Hits	258	Shared Neighborhood Hits	27
SwissProt Accessions	Q12815	Gene names	TROAP
Domain Architecture	No domain graphic available
Description	Trophinin-associated protein (Tastin) (Trophinin-assisting protein).

CSKI2_MOUSE
θ value	0.0431538 (rank : 117)	NC score	0.106947 (rank : 105)
Query Neighborhood Hits	275	Target Neighborhood Hits	812	Shared Neighborhood Hits	111
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CSKI2_HUMAN
θ value	0.0563607 (rank : 118)	NC score	0.106215 (rank : 106)
Query Neighborhood Hits	275	Target Neighborhood Hits	747	Shared Neighborhood Hits	108
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

EPHA5_MOUSE
θ value	0.0563607 (rank : 119)	NC score	0.055629 (rank : 190)
Query Neighborhood Hits	275	Target Neighborhood Hits	950	Shared Neighborhood Hits	48
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

EPHB2_HUMAN
θ value	0.0563607 (rank : 120)	NC score	0.064155 (rank : 158)
Query Neighborhood Hits	275	Target Neighborhood Hits	983	Shared Neighborhood Hits	49
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	0.0563607 (rank : 121)	NC score	0.063647 (rank : 161)
Query Neighborhood Hits	275	Target Neighborhood Hits	982	Shared Neighborhood Hits	49
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

K0310_HUMAN
θ value	0.0563607 (rank : 122)	NC score	0.049446 (rank : 227)
Query Neighborhood Hits	275	Target Neighborhood Hits	420	Shared Neighborhood Hits	35
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

K1802_HUMAN
θ value	0.0563607 (rank : 123)	NC score	0.029864 (rank : 261)
Query Neighborhood Hits	275	Target Neighborhood Hits	1378	Shared Neighborhood Hits	77
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

EPHA2_HUMAN
θ value	0.0736092 (rank : 124)	NC score	0.062786 (rank : 164)
Query Neighborhood Hits	275	Target Neighborhood Hits	1021	Shared Neighborhood Hits	48
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHB4_MOUSE
θ value	0.0736092 (rank : 125)	NC score	0.060567 (rank : 174)
Query Neighborhood Hits	275	Target Neighborhood Hits	1013	Shared Neighborhood Hits	48
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

TXLNB_HUMAN
θ value	0.0736092 (rank : 126)	NC score	0.020883 (rank : 280)
Query Neighborhood Hits	275	Target Neighborhood Hits	912	Shared Neighborhood Hits	40
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

BAT2_HUMAN
θ value	0.0961366 (rank : 127)	NC score	0.066586 (rank : 147)
Query Neighborhood Hits	275	Target Neighborhood Hits	931	Shared Neighborhood Hits	74
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

EPHB3_HUMAN
θ value	0.0961366 (rank : 128)	NC score	0.062641 (rank : 165)
Query Neighborhood Hits	275	Target Neighborhood Hits	996	Shared Neighborhood Hits	49
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHB4_HUMAN
θ value	0.0961366 (rank : 129)	NC score	0.060007 (rank : 176)
Query Neighborhood Hits	275	Target Neighborhood Hits	1056	Shared Neighborhood Hits	48
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

CASC3_HUMAN
θ value	0.125558 (rank : 130)	NC score	0.041141 (rank : 238)
Query Neighborhood Hits	275	Target Neighborhood Hits	204	Shared Neighborhood Hits	21
SwissProt Accessions	O15234	Gene names	CASC3, MLN51
Domain Architecture	No domain graphic available
Description	Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node protein 51) (Protein MLN 51) (Protein barentsz) (Btz).

CSKI1_MOUSE
θ value	0.125558 (rank : 131)	NC score	0.099085 (rank : 109)
Query Neighborhood Hits	275	Target Neighborhood Hits	1031	Shared Neighborhood Hits	117
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

FARP1_HUMAN
θ value	0.125558 (rank : 132)	NC score	0.051292 (rank : 217)
Query Neighborhood Hits	275	Target Neighborhood Hits	241	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

MTMRD_HUMAN
θ value	0.125558 (rank : 133)	NC score	0.050429 (rank : 225)
Query Neighborhood Hits	275	Target Neighborhood Hits	135	Shared Neighborhood Hits	34
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

MYO10_HUMAN
θ value	0.125558 (rank : 134)	NC score	0.076050 (rank : 130)
Query Neighborhood Hits	275	Target Neighborhood Hits	920	Shared Neighborhood Hits	66
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

PKDRE_MOUSE
θ value	0.125558 (rank : 135)	NC score	0.029246 (rank : 263)
Query Neighborhood Hits	275	Target Neighborhood Hits	76	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

PKHA2_HUMAN
θ value	0.125558 (rank : 136)	NC score	0.161017 (rank : 100)
Query Neighborhood Hits	275	Target Neighborhood Hits	119	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

CYH2_HUMAN
θ value	0.163984 (rank : 137)	NC score	0.087342 (rank : 118)
Query Neighborhood Hits	275	Target Neighborhood Hits	175	Shared Neighborhood Hits	45
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	0.163984 (rank : 138)	NC score	0.087183 (rank : 119)
Query Neighborhood Hits	275	Target Neighborhood Hits	171	Shared Neighborhood Hits	44
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

EPHB6_HUMAN
θ value	0.163984 (rank : 139)	NC score	0.077104 (rank : 128)
Query Neighborhood Hits	275	Target Neighborhood Hits	912	Shared Neighborhood Hits	46
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

PKHA6_HUMAN
θ value	0.163984 (rank : 140)	NC score	0.160170 (rank : 101)
Query Neighborhood Hits	275	Target Neighborhood Hits	556	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

DLG5_HUMAN
θ value	0.21417 (rank : 141)	NC score	0.017922 (rank : 289)
Query Neighborhood Hits	275	Target Neighborhood Hits	1088	Shared Neighborhood Hits	42
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

EPHB3_MOUSE
θ value	0.21417 (rank : 142)	NC score	0.061622 (rank : 169)
Query Neighborhood Hits	275	Target Neighborhood Hits	996	Shared Neighborhood Hits	48
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

EPHB6_MOUSE
θ value	0.21417 (rank : 143)	NC score	0.076422 (rank : 129)
Query Neighborhood Hits	275	Target Neighborhood Hits	906	Shared Neighborhood Hits	45
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

HSF1_MOUSE
θ value	0.21417 (rank : 144)	NC score	0.056924 (rank : 184)
Query Neighborhood Hits	275	Target Neighborhood Hits	267	Shared Neighborhood Hits	27
SwissProt Accessions	P38532, O70462	Gene names	Hsf1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

NEK1_MOUSE
θ value	0.21417 (rank : 145)	NC score	0.013174 (rank : 304)
Query Neighborhood Hits	275	Target Neighborhood Hits	1311	Shared Neighborhood Hits	44
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

TARA_HUMAN
θ value	0.279714 (rank : 146)	NC score	0.035526 (rank : 247)
Query Neighborhood Hits	275	Target Neighborhood Hits	1626	Shared Neighborhood Hits	89
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

CNKR1_HUMAN
θ value	0.365318 (rank : 147)	NC score	0.083945 (rank : 123)
Query Neighborhood Hits	275	Target Neighborhood Hits	154	Shared Neighborhood Hits	47
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CYH1_HUMAN
θ value	0.365318 (rank : 148)	NC score	0.090093 (rank : 117)
Query Neighborhood Hits	275	Target Neighborhood Hits	184	Shared Neighborhood Hits	43
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
θ value	0.365318 (rank : 149)	NC score	0.091058 (rank : 115)
Query Neighborhood Hits	275	Target Neighborhood Hits	176	Shared Neighborhood Hits	44
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

CYH3_HUMAN
θ value	0.365318 (rank : 150)	NC score	0.085066 (rank : 121)
Query Neighborhood Hits	275	Target Neighborhood Hits	137	Shared Neighborhood Hits	42
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

K1688_MOUSE
θ value	0.365318 (rank : 151)	NC score	0.308949 (rank : 90)
Query Neighborhood Hits	275	Target Neighborhood Hits	188	Shared Neighborhood Hits	76
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

MDC1_MOUSE
θ value	0.365318 (rank : 152)	NC score	0.048607 (rank : 228)
Query Neighborhood Hits	275	Target Neighborhood Hits	998	Shared Neighborhood Hits	66
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

PO121_HUMAN
θ value	0.365318 (rank : 153)	NC score	0.036814 (rank : 245)
Query Neighborhood Hits	275	Target Neighborhood Hits	344	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y2N3, O75115, Q9Y4S7	Gene names	POM121, KIAA0618, NUP121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa) (P145).

SON_HUMAN
θ value	0.365318 (rank : 154)	NC score	0.046967 (rank : 229)
Query Neighborhood Hits	275	Target Neighborhood Hits	1568	Shared Neighborhood Hits	90
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

SETX_HUMAN
θ value	0.47712 (rank : 155)	NC score	0.019827 (rank : 283)
Query Neighborhood Hits	275	Target Neighborhood Hits	368	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z333, O75120, Q3KQX4, Q68DW5, Q6AZD7, Q7Z3J6, Q8WX33, Q9H9D1, Q9NVP9	Gene names	SETX, ALS4, KIAA0625, SCAR1
Domain Architecture
Description	Probable helicase senataxin (EC 3.6.1.-) (SEN1 homolog).

ATX7_HUMAN
θ value	0.62314 (rank : 156)	NC score	0.024923 (rank : 272)
Query Neighborhood Hits	275	Target Neighborhood Hits	351	Shared Neighborhood Hits	29
SwissProt Accessions	O15265, O75328, O75329, Q9Y6P8	Gene names	ATXN7, SCA7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein).

CA036_MOUSE
θ value	0.62314 (rank : 157)	NC score	0.032989 (rank : 253)
Query Neighborhood Hits	275	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BRE0, Q9CRS3, Q9JMF2	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf36 homolog.

EPHAA_HUMAN
θ value	0.62314 (rank : 158)	NC score	0.065701 (rank : 151)
Query Neighborhood Hits	275	Target Neighborhood Hits	960	Shared Neighborhood Hits	47
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

FARP2_HUMAN
θ value	0.62314 (rank : 159)	NC score	0.042365 (rank : 236)
Query Neighborhood Hits	275	Target Neighborhood Hits	240	Shared Neighborhood Hits	46
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

K1543_MOUSE
θ value	0.62314 (rank : 160)	NC score	0.053737 (rank : 199)
Query Neighborhood Hits	275	Target Neighborhood Hits	497	Shared Neighborhood Hits	51
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

RGS3_MOUSE
θ value	0.62314 (rank : 161)	NC score	0.044587 (rank : 232)
Query Neighborhood Hits	275	Target Neighborhood Hits	1621	Shared Neighborhood Hits	98
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

SHAN2_MOUSE
θ value	0.62314 (rank : 162)	NC score	0.056202 (rank : 189)
Query Neighborhood Hits	275	Target Neighborhood Hits	446	Shared Neighborhood Hits	58
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

TULP4_HUMAN
θ value	0.62314 (rank : 163)	NC score	0.037312 (rank : 244)
Query Neighborhood Hits	275	Target Neighborhood Hits	426	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NRJ4, Q9HD22, Q9P2F0	Gene names	TULP4, KIAA1397, TUSP
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

FA47A_HUMAN
θ value	0.813845 (rank : 164)	NC score	0.030411 (rank : 260)
Query Neighborhood Hits	275	Target Neighborhood Hits	451	Shared Neighborhood Hits	39
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

I20L2_HUMAN
θ value	0.813845 (rank : 165)	NC score	0.041857 (rank : 237)
Query Neighborhood Hits	275	Target Neighborhood Hits	42	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H9L3, Q64KA2	Gene names	ISG20L2
Domain Architecture
Description	Interferon-stimulated 20 kDa exonuclease-like 2 (EC 3.1.-.-).

M3K14_HUMAN
θ value	0.813845 (rank : 166)	NC score	0.012942 (rank : 305)
Query Neighborhood Hits	275	Target Neighborhood Hits	887	Shared Neighborhood Hits	45
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

OGFR_HUMAN
θ value	0.813845 (rank : 167)	NC score	0.043518 (rank : 234)
Query Neighborhood Hits	275	Target Neighborhood Hits	1582	Shared Neighborhood Hits	92
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

PCLO_HUMAN
θ value	0.813845 (rank : 168)	NC score	0.040399 (rank : 239)
Query Neighborhood Hits	275	Target Neighborhood Hits	2046	Shared Neighborhood Hits	105
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

SAPS1_HUMAN
θ value	0.813845 (rank : 169)	NC score	0.028915 (rank : 266)
Query Neighborhood Hits	275	Target Neighborhood Hits	704	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

SASH1_HUMAN
θ value	0.813845 (rank : 170)	NC score	0.064646 (rank : 156)
Query Neighborhood Hits	275	Target Neighborhood Hits	292	Shared Neighborhood Hits	54
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

BCLF1_HUMAN
θ value	1.06291 (rank : 171)	NC score	0.018204 (rank : 287)
Query Neighborhood Hits	275	Target Neighborhood Hits	298	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NYF8, Q14673, Q86WU6, Q86WY0	Gene names	BCLAF1, BTF, KIAA0164
Domain Architecture	No domain graphic available
Description	Bcl-2-associated transcription factor 1 (Btf).

DTX1_HUMAN
θ value	1.06291 (rank : 172)	NC score	0.015748 (rank : 294)
Query Neighborhood Hits	275	Target Neighborhood Hits	80	Shared Neighborhood Hits	14
SwissProt Accessions	Q86Y01, O60630, Q9BS04	Gene names	DTX1
Domain Architecture
Description	Protein deltex-1 (Deltex-1) (Deltex1) (hDTX1).

FARP2_MOUSE
θ value	1.06291 (rank : 173)	NC score	0.038470 (rank : 242)
Query Neighborhood Hits	275	Target Neighborhood Hits	209	Shared Neighborhood Hits	41
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FOXN4_MOUSE
θ value	1.06291 (rank : 174)	NC score	0.006362 (rank : 324)
Query Neighborhood Hits	275	Target Neighborhood Hits	154	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K3Q3, Q920C0	Gene names	Foxn4
Domain Architecture
Description	Forkhead box protein N4.

HSF1_HUMAN
θ value	1.06291 (rank : 175)	NC score	0.040031 (rank : 240)
Query Neighborhood Hits	275	Target Neighborhood Hits	163	Shared Neighborhood Hits	14
SwissProt Accessions	Q00613	Gene names	HSF1, HSTF1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

IASPP_MOUSE
θ value	1.06291 (rank : 176)	NC score	0.066581 (rank : 148)
Query Neighborhood Hits	275	Target Neighborhood Hits	1024	Shared Neighborhood Hits	79
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

K1688_HUMAN
θ value	1.06291 (rank : 177)	NC score	0.299696 (rank : 91)
Query Neighborhood Hits	275	Target Neighborhood Hits	217	Shared Neighborhood Hits	74
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

BAT3_HUMAN
θ value	1.38821 (rank : 178)	NC score	0.031587 (rank : 254)
Query Neighborhood Hits	275	Target Neighborhood Hits	490	Shared Neighborhood Hits	44
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

CYH3_MOUSE
θ value	1.38821 (rank : 179)	NC score	0.077807 (rank : 127)
Query Neighborhood Hits	275	Target Neighborhood Hits	148	Shared Neighborhood Hits	41
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

DLG3_HUMAN
θ value	1.38821 (rank : 180)	NC score	0.008616 (rank : 318)
Query Neighborhood Hits	275	Target Neighborhood Hits	269	Shared Neighborhood Hits	12
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG3_MOUSE
θ value	1.38821 (rank : 181)	NC score	0.008594 (rank : 319)
Query Neighborhood Hits	275	Target Neighborhood Hits	274	Shared Neighborhood Hits	12
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

MILK2_HUMAN
θ value	1.38821 (rank : 182)	NC score	0.017366 (rank : 291)
Query Neighborhood Hits	275	Target Neighborhood Hits	457	Shared Neighborhood Hits	31
SwissProt Accessions	Q8IY33, Q7RTP4, Q7Z655, Q8TEQ4, Q9H5F9	Gene names
Domain Architecture
Description	MICAL-like protein 2.

NKRF_MOUSE
θ value	1.38821 (rank : 183)	NC score	0.018989 (rank : 285)
Query Neighborhood Hits	275	Target Neighborhood Hits	67	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BY02, Q8BJU5, Q9CRL2	Gene names	Nkrf, Nrf
Domain Architecture
Description	NF-kappa-B-repressing factor (NFKB-repressing factor) (Transcription factor NRF).

PKD1_HUMAN
θ value	1.38821 (rank : 184)	NC score	0.009968 (rank : 314)
Query Neighborhood Hits	275	Target Neighborhood Hits	387	Shared Neighborhood Hits	9
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

STK10_MOUSE
θ value	1.38821 (rank : 185)	NC score	0.011118 (rank : 312)
Query Neighborhood Hits	275	Target Neighborhood Hits	2132	Shared Neighborhood Hits	69
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

TNR8_HUMAN
θ value	1.38821 (rank : 186)	NC score	0.014316 (rank : 302)
Query Neighborhood Hits	275	Target Neighborhood Hits	198	Shared Neighborhood Hits	8
SwissProt Accessions	P28908	Gene names	TNFRSF8, CD30
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 8 precursor (CD30L receptor) (Lymphocyte activation antigen CD30) (KI-1 antigen).

BAT3_MOUSE
θ value	1.81305 (rank : 187)	NC score	0.036554 (rank : 246)
Query Neighborhood Hits	275	Target Neighborhood Hits	518	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

DCC_MOUSE
θ value	1.81305 (rank : 188)	NC score	0.018608 (rank : 286)
Query Neighborhood Hits	275	Target Neighborhood Hits	896	Shared Neighborhood Hits	61
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

DEND_MOUSE
θ value	1.81305 (rank : 189)	NC score	0.020135 (rank : 281)
Query Neighborhood Hits	275	Target Neighborhood Hits	75	Shared Neighborhood Hits	10
SwissProt Accessions	Q80TS7	Gene names	Ddn, Kiaa0749
Domain Architecture	No domain graphic available
Description	Dendrin.

EPHA6_MOUSE
θ value	1.81305 (rank : 190)	NC score	0.068525 (rank : 142)
Query Neighborhood Hits	275	Target Neighborhood Hits	946	Shared Neighborhood Hits	46
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

GRB7_HUMAN
θ value	1.81305 (rank : 191)	NC score	0.022365 (rank : 277)
Query Neighborhood Hits	275	Target Neighborhood Hits	156	Shared Neighborhood Hits	18
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

IWS1_MOUSE
θ value	1.81305 (rank : 192)	NC score	0.018174 (rank : 288)
Query Neighborhood Hits	275	Target Neighborhood Hits	1258	Shared Neighborhood Hits	57
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

KCNH2_MOUSE
θ value	1.81305 (rank : 193)	NC score	0.007762 (rank : 323)
Query Neighborhood Hits	275	Target Neighborhood Hits	165	Shared Neighborhood Hits	13
SwissProt Accessions	O35219, O35220, O35221, O35989	Gene names	Kcnh2, Erg, Merg1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (ERG1) (MERG) (Merg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1).

SNAG_MOUSE
θ value	1.81305 (rank : 194)	NC score	0.030588 (rank : 258)
Query Neighborhood Hits	275	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CWZ7, Q3TPT4	Gene names	Napg, Snapg
Domain Architecture	No domain graphic available
Description	Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide- sensitive factor attachment protein, gamma).

SRRM2_MOUSE
θ value	1.81305 (rank : 195)	NC score	0.038748 (rank : 241)
Query Neighborhood Hits	275	Target Neighborhood Hits	1470	Shared Neighborhood Hits	89
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

UBQL4_HUMAN
θ value	1.81305 (rank : 196)	NC score	0.010894 (rank : 313)
Query Neighborhood Hits	275	Target Neighborhood Hits	117	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NRR5, Q9BR98, Q9UHX4	Gene names	UBQLN4, C1orf6, UBIN
Domain Architecture
Description	Ubiquilin-4 (Ataxin-1 ubiquitin-like-interacting protein A1U).

3BP2_HUMAN
θ value	2.36792 (rank : 197)	NC score	0.080452 (rank : 125)
Query Neighborhood Hits	275	Target Neighborhood Hits	296	Shared Neighborhood Hits	56
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

AP180_HUMAN
θ value	2.36792 (rank : 198)	NC score	0.026921 (rank : 268)
Query Neighborhood Hits	275	Target Neighborhood Hits	183	Shared Neighborhood Hits	34
SwissProt Accessions	O60641, Q5JX13, Q68DL9, Q6P9D3, Q9NTY7	Gene names	SNAP91, KIAA0656
Domain Architecture
Description	Clathrin coat assembly protein AP180 (Clathrin coat-associated protein AP180) (91 kDa synaptosomal-associated protein).

AP180_MOUSE
θ value	2.36792 (rank : 199)	NC score	0.029211 (rank : 264)
Query Neighborhood Hits	275	Target Neighborhood Hits	194	Shared Neighborhood Hits	33
SwissProt Accessions	Q61548, Q61547	Gene names	Snap91
Domain Architecture
Description	Clathrin coat assembly protein AP180 (Clathrin coat-associated protein AP180) (91 kDa synaptosomal-associated protein) (Phosphoprotein F1- 20).

CASC3_MOUSE
θ value	2.36792 (rank : 200)	NC score	0.034180 (rank : 250)
Query Neighborhood Hits	275	Target Neighborhood Hits	333	Shared Neighborhood Hits	27
SwissProt Accessions	Q8K3W3, Q8K219, Q99NF0	Gene names	Casc3, Mln51
Domain Architecture	No domain graphic available
Description	Protein CASC3 (Cancer susceptibility candidate gene 3 protein homolog) (Metastatic lymph node protein 51 homolog) (Protein MLN 51 homolog) (Protein barentsz) (Btz).

CNKR2_HUMAN
θ value	2.36792 (rank : 201)	NC score	0.060394 (rank : 175)
Query Neighborhood Hits	275	Target Neighborhood Hits	197	Shared Neighborhood Hits	42
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	2.36792 (rank : 202)	NC score	0.060726 (rank : 172)
Query Neighborhood Hits	275	Target Neighborhood Hits	197	Shared Neighborhood Hits	42
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CYH4_HUMAN
θ value	2.36792 (rank : 203)	NC score	0.069088 (rank : 140)
Query Neighborhood Hits	275	Target Neighborhood Hits	135	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

G7C_HUMAN
θ value	2.36792 (rank : 204)	NC score	0.014474 (rank : 301)
Query Neighborhood Hits	275	Target Neighborhood Hits	21	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y334, Q5SSR5, Q96QC8, Q9UMP9	Gene names	C6orf27, G7C, NG37
Domain Architecture	No domain graphic available
Description	Protein G7c precursor.

HXA10_HUMAN
θ value	2.36792 (rank : 205)	NC score	0.000803 (rank : 336)
Query Neighborhood Hits	275	Target Neighborhood Hits	334	Shared Neighborhood Hits	8
SwissProt Accessions	P31260, O43370, O43605, Q15949	Gene names	HOXA10, HOX1H
Domain Architecture
Description	Homeobox protein Hox-A10 (Hox-1H) (Hox-1.8) (PL).

HXB4_MOUSE
θ value	2.36792 (rank : 206)	NC score	0.000494 (rank : 338)
Query Neighborhood Hits	275	Target Neighborhood Hits	375	Shared Neighborhood Hits	15
SwissProt Accessions	P10284, Q3UZB4, Q4VBG0	Gene names	Hoxb4, Hox-2.6, Hoxb-4
Domain Architecture
Description	Homeobox protein Hox-B4 (Hox-2.6).

IRF3_HUMAN
θ value	2.36792 (rank : 207)	NC score	0.014500 (rank : 300)
Query Neighborhood Hits	275	Target Neighborhood Hits	129	Shared Neighborhood Hits	10
SwissProt Accessions	Q14653	Gene names	IRF3
Domain Architecture
Description	Interferon regulatory factor 3 (IRF-3).

JIP2_HUMAN
θ value	2.36792 (rank : 208)	NC score	0.029384 (rank : 262)
Query Neighborhood Hits	275	Target Neighborhood Hits	288	Shared Neighborhood Hits	25
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

MKL1_MOUSE
θ value	2.36792 (rank : 209)	NC score	0.045492 (rank : 230)
Query Neighborhood Hits	275	Target Neighborhood Hits	667	Shared Neighborhood Hits	55
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

NFAT5_HUMAN
θ value	2.36792 (rank : 210)	NC score	0.008829 (rank : 317)
Query Neighborhood Hits	275	Target Neighborhood Hits	217	Shared Neighborhood Hits	8
SwissProt Accessions	O94916, O95693, Q9UN18	Gene names	NFAT5, KIAA0827, TONEBP
Domain Architecture
Description	Nuclear factor of activated T-cells 5 (T-cell transcription factor NFAT5) (NF-AT5) (Tonicity-responsive enhancer-binding protein) (TonE- binding protein) (TonEBP).

RTP3_MOUSE
θ value	2.36792 (rank : 211)	NC score	0.035093 (rank : 248)
Query Neighborhood Hits	275	Target Neighborhood Hits	374	Shared Neighborhood Hits	36
SwissProt Accessions	Q5QGU6, Q8VDC2	Gene names	Rtp3, Tmem7
Domain Architecture	No domain graphic available
Description	Receptor-transporting protein 3 (Transmembrane protein 7).

SHAN2_HUMAN
θ value	2.36792 (rank : 212)	NC score	0.051583 (rank : 216)
Query Neighborhood Hits	275	Target Neighborhood Hits	346	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

ARI1B_HUMAN
θ value	3.0926 (rank : 213)	NC score	0.023836 (rank : 274)
Query Neighborhood Hits	275	Target Neighborhood Hits	567	Shared Neighborhood Hits	45
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

CNOT4_MOUSE
θ value	3.0926 (rank : 214)	NC score	0.012618 (rank : 306)
Query Neighborhood Hits	275	Target Neighborhood Hits	277	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BT14, Q8CCR4, Q9CV74, Q9Z1D0	Gene names	Cnot4, Not4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

CSPG3_HUMAN
θ value	3.0926 (rank : 215)	NC score	0.002360 (rank : 332)
Query Neighborhood Hits	275	Target Neighborhood Hits	676	Shared Neighborhood Hits	30
SwissProt Accessions	O14594, Q9UPK6	Gene names	CSPG3, NCAN, NEUR
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

GFI1_HUMAN
θ value	3.0926 (rank : 216)	NC score	-0.006810 (rank : 341)
Query Neighborhood Hits	275	Target Neighborhood Hits	726	Shared Neighborhood Hits	7
SwissProt Accessions	Q99684, Q8N564	Gene names	GFI1, ZNF163
Domain Architecture	No domain graphic available
Description	Zinc finger protein Gfi-1 (Growth factor independence 1).

MAP1B_HUMAN
θ value	3.0926 (rank : 217)	NC score	0.014925 (rank : 298)
Query Neighborhood Hits	275	Target Neighborhood Hits	903	Shared Neighborhood Hits	40
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

SNAG_HUMAN
θ value	3.0926 (rank : 218)	NC score	0.027140 (rank : 267)
Query Neighborhood Hits	275	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	Q99747, Q9BUV1	Gene names	NAPG, SNAPG
Domain Architecture	No domain graphic available
Description	Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide- sensitive factor attachment protein, gamma).

SON_MOUSE
θ value	3.0926 (rank : 219)	NC score	0.030678 (rank : 257)
Query Neighborhood Hits	275	Target Neighborhood Hits	957	Shared Neighborhood Hits	66
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

ZN687_HUMAN
θ value	3.0926 (rank : 220)	NC score	0.001759 (rank : 335)
Query Neighborhood Hits	275	Target Neighborhood Hits	1244	Shared Neighborhood Hits	49
SwissProt Accessions	Q8N1G0, Q68DQ8, Q9H937, Q9P2A7	Gene names	ZNF687, KIAA1441
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

ABCA5_MOUSE
θ value	4.03905 (rank : 221)	NC score	0.003257 (rank : 331)
Query Neighborhood Hits	275	Target Neighborhood Hits	137	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K448, Q3TE17, Q3UUB4, Q6P1Y0, Q6ZPG4, Q810C7, Q8BM46, Q8BXG7	Gene names	Abca5, Kiaa1888
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 5.

BSN_MOUSE
θ value	4.03905 (rank : 222)	NC score	0.043100 (rank : 235)
Query Neighborhood Hits	275	Target Neighborhood Hits	2057	Shared Neighborhood Hits	106
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CYH4_MOUSE
θ value	4.03905 (rank : 223)	NC score	0.069793 (rank : 136)
Query Neighborhood Hits	275	Target Neighborhood Hits	134	Shared Neighborhood Hits	41
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

FMN2_MOUSE
θ value	4.03905 (rank : 224)	NC score	0.021305 (rank : 279)
Query Neighborhood Hits	275	Target Neighborhood Hits	349	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JL04	Gene names	Fmn2
Domain Architecture
Description	Formin-2.

GAK_HUMAN
θ value	4.03905 (rank : 225)	NC score	0.007943 (rank : 321)
Query Neighborhood Hits	275	Target Neighborhood Hits	1028	Shared Neighborhood Hits	47
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

MDC1_HUMAN
θ value	4.03905 (rank : 226)	NC score	0.043639 (rank : 233)
Query Neighborhood Hits	275	Target Neighborhood Hits	1446	Shared Neighborhood Hits	81
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MK15_HUMAN
θ value	4.03905 (rank : 227)	NC score	0.014841 (rank : 299)
Query Neighborhood Hits	275	Target Neighborhood Hits	1038	Shared Neighborhood Hits	58
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

PKDRE_HUMAN
θ value	4.03905 (rank : 228)	NC score	0.024195 (rank : 273)
Query Neighborhood Hits	275	Target Neighborhood Hits	64	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

PLEK_HUMAN
θ value	4.03905 (rank : 229)	NC score	0.078000 (rank : 126)
Query Neighborhood Hits	275	Target Neighborhood Hits	110	Shared Neighborhood Hits	42
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

SASH1_MOUSE
θ value	4.03905 (rank : 230)	NC score	0.061965 (rank : 168)
Query Neighborhood Hits	275	Target Neighborhood Hits	263	Shared Neighborhood Hits	55
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SRRM2_HUMAN
θ value	4.03905 (rank : 231)	NC score	0.044738 (rank : 231)
Query Neighborhood Hits	275	Target Neighborhood Hits	1296	Shared Neighborhood Hits	80
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

ARNT_MOUSE
θ value	5.27518 (rank : 232)	NC score	0.006070 (rank : 325)
Query Neighborhood Hits	275	Target Neighborhood Hits	213	Shared Neighborhood Hits	16
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

CA036_HUMAN
θ value	5.27518 (rank : 233)	NC score	0.022949 (rank : 275)
Query Neighborhood Hits	275	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z3Z2	Gene names	C1orf36
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf36.

CK024_HUMAN
θ value	5.27518 (rank : 234)	NC score	0.031207 (rank : 256)
Query Neighborhood Hits	275	Target Neighborhood Hits	408	Shared Neighborhood Hits	43
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

CK5P2_MOUSE
θ value	5.27518 (rank : 235)	NC score	0.001909 (rank : 334)
Query Neighborhood Hits	275	Target Neighborhood Hits	1151	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

FMN2_HUMAN
θ value	5.27518 (rank : 236)	NC score	0.026292 (rank : 270)
Query Neighborhood Hits	275	Target Neighborhood Hits	484	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

K1543_HUMAN
θ value	5.27518 (rank : 237)	NC score	0.033344 (rank : 252)
Query Neighborhood Hits	275	Target Neighborhood Hits	435	Shared Neighborhood Hits	41
SwissProt Accessions	Q9P1Y5, Q8NDF1	Gene names	KIAA1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

LRSM1_HUMAN
θ value	5.27518 (rank : 238)	NC score	0.007922 (rank : 322)
Query Neighborhood Hits	275	Target Neighborhood Hits	1078	Shared Neighborhood Hits	35
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

POZP3_HUMAN
θ value	5.27518 (rank : 239)	NC score	0.015661 (rank : 295)
Query Neighborhood Hits	275	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PJE2, Q12903, Q9BWB4	Gene names	POMZP3
Domain Architecture	No domain graphic available
Description	POM121 and ZP3 fusion protein (POM-ZP3).

TAB3_MOUSE
θ value	5.27518 (rank : 240)	NC score	0.019828 (rank : 282)
Query Neighborhood Hits	275	Target Neighborhood Hits	273	Shared Neighborhood Hits	22
SwissProt Accessions	Q571K4	Gene names	Map3k7ip3, Kiaa4135, Tab3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3).

VTNC_MOUSE
θ value	5.27518 (rank : 241)	NC score	0.005099 (rank : 327)
Query Neighborhood Hits	275	Target Neighborhood Hits	74	Shared Neighborhood Hits	5
SwissProt Accessions	P29788, Q8VII4	Gene names	Vtn
Domain Architecture
Description	Vitronectin precursor (Serum-spreading factor) (S-protein).

3BP2_MOUSE
θ value	6.88961 (rank : 242)	NC score	0.069203 (rank : 139)
Query Neighborhood Hits	275	Target Neighborhood Hits	142	Shared Neighborhood Hits	48
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

BMX_HUMAN
θ value	6.88961 (rank : 243)	NC score	0.028946 (rank : 265)
Query Neighborhood Hits	275	Target Neighborhood Hits	942	Shared Neighborhood Hits	53
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

CDT1_HUMAN
θ value	6.88961 (rank : 244)	NC score	0.011583 (rank : 309)
Query Neighborhood Hits	275	Target Neighborhood Hits	92	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H211, Q86XX9, Q96CJ5, Q96GK5, Q96H67, Q96HE6, Q9BWM0	Gene names	CDT1
Domain Architecture	No domain graphic available
Description	DNA replication factor Cdt1 (Double parked homolog) (DUP).

CECR2_HUMAN
θ value	6.88961 (rank : 245)	NC score	0.025437 (rank : 271)
Query Neighborhood Hits	275	Target Neighborhood Hits	543	Shared Neighborhood Hits	41
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

CEL_HUMAN
θ value	6.88961 (rank : 246)	NC score	0.016339 (rank : 292)
Query Neighborhood Hits	275	Target Neighborhood Hits	896	Shared Neighborhood Hits	55
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

CK035_HUMAN
θ value	6.88961 (rank : 247)	NC score	0.011218 (rank : 311)
Query Neighborhood Hits	275	Target Neighborhood Hits	149	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IXW0	Gene names	C11orf35
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf35.

CN004_HUMAN
θ value	6.88961 (rank : 248)	NC score	0.015506 (rank : 296)
Query Neighborhood Hits	275	Target Neighborhood Hits	108	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H1B7, Q8NDQ2, Q96JG2, Q9H3I7	Gene names	C14orf4, KIAA1865
Domain Architecture	No domain graphic available
Description	Protein C14orf4.

CN004_MOUSE
θ value	6.88961 (rank : 249)	NC score	0.015923 (rank : 293)
Query Neighborhood Hits	275	Target Neighborhood Hits	105	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K3X4, Q3USE5, Q8BUS1, Q8C011	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf4 homolog.

COHA1_MOUSE
θ value	6.88961 (rank : 250)	NC score	0.009740 (rank : 315)
Query Neighborhood Hits	275	Target Neighborhood Hits	414	Shared Neighborhood Hits	36
SwissProt Accessions	Q07563, Q99LK8	Gene names	Col17a1, Bp180, Bpag2
Domain Architecture
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

ELK4_HUMAN
θ value	6.88961 (rank : 251)	NC score	0.003424 (rank : 330)
Query Neighborhood Hits	275	Target Neighborhood Hits	184	Shared Neighborhood Hits	15
SwissProt Accessions	P28324, P28323	Gene names	ELK4, SAP1
Domain Architecture
Description	ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1).

GAB2_MOUSE
θ value	6.88961 (rank : 252)	NC score	0.072201 (rank : 132)
Query Neighborhood Hits	275	Target Neighborhood Hits	220	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

GAK3_HUMAN
θ value	6.88961 (rank : 253)	NC score	0.002343 (rank : 333)
Query Neighborhood Hits	275	Target Neighborhood Hits	182	Shared Neighborhood Hits	9
SwissProt Accessions	Q9YNA8	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19q12 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(C19) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

JIP1_HUMAN
θ value	6.88961 (rank : 254)	NC score	0.011830 (rank : 308)
Query Neighborhood Hits	275	Target Neighborhood Hits	271	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

MTMR5_HUMAN
θ value	6.88961 (rank : 255)	NC score	0.034580 (rank : 249)
Query Neighborhood Hits	275	Target Neighborhood Hits	141	Shared Neighborhood Hits	31
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

PCLO_MOUSE
θ value	6.88961 (rank : 256)	NC score	0.031382 (rank : 255)
Query Neighborhood Hits	275	Target Neighborhood Hits	2275	Shared Neighborhood Hits	99
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PEX14_MOUSE
θ value	6.88961 (rank : 257)	NC score	0.015408 (rank : 297)
Query Neighborhood Hits	275	Target Neighborhood Hits	62	Shared Neighborhood Hits	6
SwissProt Accessions	Q9R0A0	Gene names	Pex14
Domain Architecture
Description	Peroxisomal membrane protein PEX14 (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) (PTS1 receptor docking protein).

PKHF1_MOUSE
θ value	6.88961 (rank : 258)	NC score	0.014206 (rank : 303)
Query Neighborhood Hits	275	Target Neighborhood Hits	80	Shared Neighborhood Hits	9
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

SLIT1_MOUSE
θ value	6.88961 (rank : 259)	NC score	-0.005067 (rank : 340)
Query Neighborhood Hits	275	Target Neighborhood Hits	715	Shared Neighborhood Hits	7
SwissProt Accessions	Q80TR4, Q9WVB5	Gene names	Slit1, Kiaa0813
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1).

YETS2_MOUSE
θ value	6.88961 (rank : 260)	NC score	0.011322 (rank : 310)
Query Neighborhood Hits	275	Target Neighborhood Hits	278	Shared Neighborhood Hits	26
SwissProt Accessions	Q3TUF7, Q6PGF8, Q80TI2, Q8CG86	Gene names	Yeats2, Kiaa1197
Domain Architecture	No domain graphic available
Description	YEATS domain-containing protein 2.

ZN202_HUMAN
θ value	6.88961 (rank : 261)	NC score	-0.007367 (rank : 342)
Query Neighborhood Hits	275	Target Neighborhood Hits	756	Shared Neighborhood Hits	10
SwissProt Accessions	O95125, Q4JG21, Q9H1B9, Q9NSM4	Gene names	ZNF202
Domain Architecture
Description	Zinc finger protein 202.

ABL1_HUMAN
θ value	8.99809 (rank : 262)	NC score	0.033825 (rank : 251)
Query Neighborhood Hits	275	Target Neighborhood Hits	1220	Shared Neighborhood Hits	70
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

AZI1_HUMAN
θ value	8.99809 (rank : 263)	NC score	0.004261 (rank : 329)
Query Neighborhood Hits	275	Target Neighborhood Hits	1000	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

BSN_HUMAN
θ value	8.99809 (rank : 264)	NC score	0.030500 (rank : 259)
Query Neighborhood Hits	275	Target Neighborhood Hits	1537	Shared Neighborhood Hits	91
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

LR37A_HUMAN
θ value	8.99809 (rank : 265)	NC score	0.012305 (rank : 307)
Query Neighborhood Hits	275	Target Neighborhood Hits	720	Shared Neighborhood Hits	47
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

MAP1A_HUMAN
θ value	8.99809 (rank : 266)	NC score	0.019027 (rank : 284)
Query Neighborhood Hits	275	Target Neighborhood Hits	1626	Shared Neighborhood Hits	69
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

MEGF9_MOUSE
θ value	8.99809 (rank : 267)	NC score	0.009685 (rank : 316)
Query Neighborhood Hits	275	Target Neighborhood Hits	896	Shared Neighborhood Hits	58
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

NCOA6_HUMAN
θ value	8.99809 (rank : 268)	NC score	0.038264 (rank : 243)
Query Neighborhood Hits	275	Target Neighborhood Hits	1202	Shared Neighborhood Hits	78
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

NIPA_HUMAN
θ value	8.99809 (rank : 269)	NC score	0.008426 (rank : 320)
Query Neighborhood Hits	275	Target Neighborhood Hits	37	Shared Neighborhood Hits	7
SwissProt Accessions	Q86WB0, Q75MF3, Q75MF4, Q8N330, Q96F75, Q9HA34, Q9NVX4, Q9P0R0	Gene names	ZC3HC1, NIPA
Domain Architecture	No domain graphic available
Description	Nuclear-interacting partner of ALK (Nuclear-interacting partner of anaplastic lymphoma kinase) (hNIPA) (Zinc finger C3HC-type protein 1).

PLCG1_HUMAN
θ value	8.99809 (rank : 270)	NC score	0.021988 (rank : 278)
Query Neighborhood Hits	275	Target Neighborhood Hits	293	Shared Neighborhood Hits	27
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	8.99809 (rank : 271)	NC score	0.022538 (rank : 276)
Query Neighborhood Hits	275	Target Neighborhood Hits	314	Shared Neighborhood Hits	26
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SSBP4_HUMAN
θ value	8.99809 (rank : 272)	NC score	0.026303 (rank : 269)
Query Neighborhood Hits	275	Target Neighborhood Hits	753	Shared Neighborhood Hits	53
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

TRI56_HUMAN
θ value	8.99809 (rank : 273)	NC score	0.000651 (rank : 337)
Query Neighborhood Hits	275	Target Neighborhood Hits	339	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BRZ2, Q86VT6, Q8N2H8, Q8NAC0, Q9H031	Gene names	TRIM56, RNF109
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 56 (RING finger protein 109).

ZFY19_MOUSE
θ value	8.99809 (rank : 274)	NC score	0.005093 (rank : 328)
Query Neighborhood Hits	275	Target Neighborhood Hits	143	Shared Neighborhood Hits	6
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

ZSWM3_MOUSE
θ value	8.99809 (rank : 275)	NC score	0.005641 (rank : 326)
Query Neighborhood Hits	275	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CFL8	Gene names	Zswim3
Domain Architecture
Description	Zinc finger SWIM domain-containing protein 3.

ANK1_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.051795 (rank : 214)
Query Neighborhood Hits	275	Target Neighborhood Hits	416	Shared Neighborhood Hits	27
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

ANK1_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.052025 (rank : 211)
Query Neighborhood Hits	275	Target Neighborhood Hits	430	Shared Neighborhood Hits	31
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

ANK2_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.053577 (rank : 200)
Query Neighborhood Hits	275	Target Neighborhood Hits	1615	Shared Neighborhood Hits	87
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

ANKR2_HUMAN
θ value	θ > 10 (rank : 279)	NC score	0.052156 (rank : 210)
Query Neighborhood Hits	275	Target Neighborhood Hits	321	Shared Neighborhood Hits	25
SwissProt Accessions	Q9GZV1, Q5T456, Q8WUD7	Gene names	ANKRD2, ARPP
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp).

ANKR6_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.053302 (rank : 202)
Query Neighborhood Hits	275	Target Neighborhood Hits	439	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y2G4, Q9NU24, Q9UFQ9	Gene names	ANKRD6, KIAA0957
Domain Architecture
Description	Ankyrin repeat domain-containing protein 6.

ANKS1_HUMAN
θ value	θ > 10 (rank : 281)	NC score	0.054743 (rank : 196)
Query Neighborhood Hits	275	Target Neighborhood Hits	438	Shared Neighborhood Hits	64
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

ANKS1_MOUSE
θ value	θ > 10 (rank : 282)	NC score	0.059193 (rank : 181)
Query Neighborhood Hits	275	Target Neighborhood Hits	453	Shared Neighborhood Hits	66
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

ANR10_HUMAN
θ value	θ > 10 (rank : 283)	NC score	0.053070 (rank : 205)
Query Neighborhood Hits	275	Target Neighborhood Hits	289	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NXR5	Gene names	ANKRD10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

ANR10_MOUSE
θ value	θ > 10 (rank : 284)	NC score	0.050906 (rank : 219)
Query Neighborhood Hits	275	Target Neighborhood Hits	273	Shared Neighborhood Hits	25
SwissProt Accessions	Q99LW0	Gene names	Ankrd10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

ANR22_HUMAN
θ value	θ > 10 (rank : 285)	NC score	0.050411 (rank : 226)
Query Neighborhood Hits	275	Target Neighborhood Hits	243	Shared Neighborhood Hits	17
SwissProt Accessions	Q5VYY1, Q8WU06	Gene names	ANKRD22
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 22.

ANR33_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.050639 (rank : 223)
Query Neighborhood Hits	275	Target Neighborhood Hits	215	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z3H0, Q5K619, Q5K621, Q5K622, Q5K623, Q5K624, Q6ZUN0	Gene names	ANKRD33, C12orf7
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

ANR37_HUMAN
θ value	θ > 10 (rank : 287)	NC score	0.061114 (rank : 170)
Query Neighborhood Hits	275	Target Neighborhood Hits	247	Shared Neighborhood Hits	22
SwissProt Accessions	Q7Z713	Gene names	ANKRD37, LPR2BP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37 (Low-density lipoprotein receptor-related protein 2-binding protein) (hLrp2bp).

ANR37_MOUSE
θ value	θ > 10 (rank : 288)	NC score	0.070779 (rank : 134)
Query Neighborhood Hits	275	Target Neighborhood Hits	237	Shared Neighborhood Hits	23
SwissProt Accessions	Q569N2, Q8CHS0	Gene names	Ankrd37
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37.

ANR39_HUMAN
θ value	θ > 10 (rank : 289)	NC score	0.064116 (rank : 159)
Query Neighborhood Hits	275	Target Neighborhood Hits	285	Shared Neighborhood Hits	25
SwissProt Accessions	Q53RE8, Q59FU2, Q8N5X5, Q9P0S5	Gene names	ANKRD39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ANR39_MOUSE
θ value	θ > 10 (rank : 290)	NC score	0.064972 (rank : 154)
Query Neighborhood Hits	275	Target Neighborhood Hits	284	Shared Neighborhood Hits	25
SwissProt Accessions	Q9D2X0	Gene names	Ankrd39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ANR41_HUMAN
θ value	θ > 10 (rank : 291)	NC score	0.069740 (rank : 137)
Query Neighborhood Hits	275	Target Neighborhood Hits	332	Shared Neighborhood Hits	26
SwissProt Accessions	Q8NAG6, Q8N8J8	Gene names	ANKRD41
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 41.

ANR42_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.053535 (rank : 201)
Query Neighborhood Hits	275	Target Neighborhood Hits	284	Shared Neighborhood Hits	25
SwissProt Accessions	Q8N9B4, Q49A49	Gene names	ANKRD42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

ANR46_HUMAN
θ value	θ > 10 (rank : 293)	NC score	0.065647 (rank : 152)
Query Neighborhood Hits	275	Target Neighborhood Hits	281	Shared Neighborhood Hits	24
SwissProt Accessions	Q86W74, Q6P9B7	Gene names	ANKRD46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

ANR46_MOUSE
θ value	θ > 10 (rank : 294)	NC score	0.064903 (rank : 155)
Query Neighborhood Hits	275	Target Neighborhood Hits	274	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BTZ5, Q1LZK9, Q8BV97	Gene names	Ankrd46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

ANR52_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.050714 (rank : 222)
Query Neighborhood Hits	275	Target Neighborhood Hits	322	Shared Neighborhood Hits	25
SwissProt Accessions	Q8NB46	Gene names	ANKRD52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ANR52_MOUSE
θ value	θ > 10 (rank : 296)	NC score	0.050776 (rank : 220)
Query Neighborhood Hits	275	Target Neighborhood Hits	318	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BTI7	Gene names	Ankrd52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ANS4B_HUMAN
θ value	θ > 10 (rank : 297)	NC score	0.055164 (rank : 193)
Query Neighborhood Hits	275	Target Neighborhood Hits	289	Shared Neighborhood Hits	23
SwissProt Accessions	Q8N8V4	Gene names	ANKS4B, HARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

ANS4B_MOUSE
θ value	θ > 10 (rank : 298)	NC score	0.059669 (rank : 177)
Query Neighborhood Hits	275	Target Neighborhood Hits	294	Shared Neighborhood Hits	24
SwissProt Accessions	Q8K3X6, Q9D8A5	Gene names	Anks4b, Harp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

ASB10_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.052761 (rank : 207)
Query Neighborhood Hits	275	Target Neighborhood Hits	291	Shared Neighborhood Hits	25
SwissProt Accessions	Q8WXI3	Gene names	ASB10
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

ASB10_MOUSE
θ value	θ > 10 (rank : 300)	NC score	0.050979 (rank : 218)
Query Neighborhood Hits	275	Target Neighborhood Hits	301	Shared Neighborhood Hits	25
SwissProt Accessions	Q91ZT7	Gene names	Asb10
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

CDN2D_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.053094 (rank : 204)
Query Neighborhood Hits	275	Target Neighborhood Hits	268	Shared Neighborhood Hits	20
SwissProt Accessions	P55273, Q13102, Q6FGE9	Gene names	CDKN2D
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

CT086_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.082361 (rank : 124)
Query Neighborhood Hits	275	Target Neighborhood Hits	277	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BZ19, Q4VXE6	Gene names	C20orf86
Domain Architecture
Description	Putative uncharacterized protein C20orf86.

DAPP1_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.090745 (rank : 116)
Query Neighborhood Hits	275	Target Neighborhood Hits	227	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 304)	NC score	0.092758 (rank : 112)
Query Neighborhood Hits	275	Target Neighborhood Hits	225	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DGKK_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.056216 (rank : 188)
Query Neighborhood Hits	275	Target Neighborhood Hits	378	Shared Neighborhood Hits	62
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

DP13A_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.095966 (rank : 110)
Query Neighborhood Hits	275	Target Neighborhood Hits	107	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13A_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.093306 (rank : 111)
Query Neighborhood Hits	275	Target Neighborhood Hits	96	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K3H0, Q3UJP7, Q69ZJ9, Q8BWZ8, Q8VCJ8, Q9CUW4	Gene names	Appl1, Dip13a, Kiaa1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13B_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.085962 (rank : 120)
Query Neighborhood Hits	275	Target Neighborhood Hits	58	Shared Neighborhood Hits	20
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

DP13B_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.091372 (rank : 114)
Query Neighborhood Hits	275	Target Neighborhood Hits	58	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

EPHA3_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.052218 (rank : 209)
Query Neighborhood Hits	275	Target Neighborhood Hits	1005	Shared Neighborhood Hits	41
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA3_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.052809 (rank : 206)
Query Neighborhood Hits	275	Target Neighborhood Hits	1009	Shared Neighborhood Hits	42
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

GAB1_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.056835 (rank : 185)
Query Neighborhood Hits	275	Target Neighborhood Hits	279	Shared Neighborhood Hits	41
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GAB2_HUMAN
θ value	θ > 10 (rank : 313)	NC score	0.067061 (rank : 145)
Query Neighborhood Hits	275	Target Neighborhood Hits	188	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

GABP2_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.058554 (rank : 182)
Query Neighborhood Hits	275	Target Neighborhood Hits	454	Shared Neighborhood Hits	27
SwissProt Accessions	Q06547, Q06545, Q12940, Q12941, Q12942, Q8IYD0	Gene names	GABPB2, E4TF1B, GABPB, GABPB1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1) (Transcription factor E4TF1-53) (Transcription factor E4TF1-47) (Nuclear respiratory factor 2).

GABP2_MOUSE
θ value	θ > 10 (rank : 315)	NC score	0.058316 (rank : 183)
Query Neighborhood Hits	275	Target Neighborhood Hits	429	Shared Neighborhood Hits	26
SwissProt Accessions	Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2	Gene names	Gabpb2, Gabpb, Gabpb1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1).

GABP3_MOUSE
θ value	θ > 10 (rank : 316)	NC score	0.060686 (rank : 173)
Query Neighborhood Hits	275	Target Neighborhood Hits	330	Shared Neighborhood Hits	25
SwissProt Accessions	P81069	Gene names	Gabpb2
Domain Architecture	No domain graphic available
Description	GA-binding protein beta-2-1 chain (GABP subunit beta-2-1) (GABPB2-1).

HECD1_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.051834 (rank : 213)
Query Neighborhood Hits	275	Target Neighborhood Hits	371	Shared Neighborhood Hits	24
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

I5P2_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.167990 (rank : 98)
Query Neighborhood Hits	275	Target Neighborhood Hits	86	Shared Neighborhood Hits	50
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

IASPP_HUMAN
θ value	θ > 10 (rank : 319)	NC score	0.059619 (rank : 178)
Query Neighborhood Hits	275	Target Neighborhood Hits	688	Shared Neighborhood Hits	64
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IKBB_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.055012 (rank : 194)
Query Neighborhood Hits	275	Target Neighborhood Hits	284	Shared Neighborhood Hits	25
SwissProt Accessions	Q15653, Q96BJ7	Gene names	NFKBIB, IKBB, TRIP9
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9).

IKBB_MOUSE
θ value	θ > 10 (rank : 321)	NC score	0.062406 (rank : 166)
Query Neighborhood Hits	275	Target Neighborhood Hits	284	Shared Neighborhood Hits	25
SwissProt Accessions	Q60778, Q9D6L5	Gene names	Nfkbib, Ikbb
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B).

ILK1_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.055555 (rank : 191)
Query Neighborhood Hits	275	Target Neighborhood Hits	857	Shared Neighborhood Hits	53
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.056472 (rank : 186)
Query Neighborhood Hits	275	Target Neighborhood Hits	848	Shared Neighborhood Hits	53
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 324)	NC score	0.054809 (rank : 195)
Query Neighborhood Hits	275	Target Neighborhood Hits	858	Shared Neighborhood Hits	54
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

MTPN_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.053939 (rank : 198)
Query Neighborhood Hits	275	Target Neighborhood Hits	269	Shared Neighborhood Hits	23
SwissProt Accessions	P58546	Gene names	MTPN
Domain Architecture
Description	Myotrophin (Protein V-1).

MTPN_MOUSE
θ value	θ > 10 (rank : 326)	NC score	0.055496 (rank : 192)
Query Neighborhood Hits	275	Target Neighborhood Hits	269	Shared Neighborhood Hits	23
SwissProt Accessions	P62774, P80144, Q543M6, Q9DCN8	Gene names	Mtpn, Gcdp
Domain Architecture	No domain graphic available
Description	Myotrophin (Protein V-1) (Granule cell differentiation protein).

MYPT1_HUMAN
θ value	θ > 10 (rank : 327)	NC score	0.052516 (rank : 208)
Query Neighborhood Hits	275	Target Neighborhood Hits	723	Shared Neighborhood Hits	34
SwissProt Accessions	O14974, Q86WU3, Q8NFR6, Q9BYH0	Gene names	PPP1R12A, MBS, MYPT1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit).

MYPT1_MOUSE
θ value	θ > 10 (rank : 328)	NC score	0.054199 (rank : 197)
Query Neighborhood Hits	275	Target Neighborhood Hits	539	Shared Neighborhood Hits	32
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

OCRL_HUMAN
θ value	θ > 10 (rank : 329)	NC score	0.171173 (rank : 97)
Query Neighborhood Hits	275	Target Neighborhood Hits	77	Shared Neighborhood Hits	51
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).

P85B_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.059300 (rank : 179)
Query Neighborhood Hits	275	Target Neighborhood Hits	543	Shared Neighborhood Hits	39
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PCTL_MOUSE
θ value	θ > 10 (rank : 331)	NC score	0.050554 (rank : 224)
Query Neighborhood Hits	275	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JMD3	Gene names	Stard10, Pctpl, Sdccag28, Sdccagg28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28 homolog).

PKHA4_HUMAN
θ value	θ > 10 (rank : 332)	NC score	0.102818 (rank : 108)
Query Neighborhood Hits	275	Target Neighborhood Hits	283	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_MOUSE
θ value	θ > 10 (rank : 333)	NC score	0.108422 (rank : 104)
Query Neighborhood Hits	275	Target Neighborhood Hits	202	Shared Neighborhood Hits	47
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA5_HUMAN
θ value	θ > 10 (rank : 334)	NC score	0.091939 (rank : 113)
Query Neighborhood Hits	275	Target Neighborhood Hits	455	Shared Neighborhood Hits	51
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PLEK2_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.061001 (rank : 171)
Query Neighborhood Hits	275	Target Neighborhood Hits	101	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_MOUSE
θ value	θ > 10 (rank : 336)	NC score	0.059199 (rank : 180)
Query Neighborhood Hits	275	Target Neighborhood Hits	96	Shared Neighborhood Hits	34
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PLEK_MOUSE
θ value	θ > 10 (rank : 337)	NC score	0.062301 (rank : 167)
Query Neighborhood Hits	275	Target Neighborhood Hits	109	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

PSD10_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.050771 (rank : 221)
Query Neighborhood Hits	275	Target Neighborhood Hits	301	Shared Neighborhood Hits	25
SwissProt Accessions	O75832	Gene names	PSMD10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

RAPH1_HUMAN
θ value	θ > 10 (rank : 339)	NC score	0.056240 (rank : 187)
Query Neighborhood Hits	275	Target Neighborhood Hits	593	Shared Neighborhood Hits	80
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

SHAN1_HUMAN
θ value	θ > 10 (rank : 340)	NC score	0.062811 (rank : 163)
Query Neighborhood Hits	275	Target Neighborhood Hits	1041	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

USH1G_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.051730 (rank : 215)
Query Neighborhood Hits	275	Target Neighborhood Hits	267	Shared Neighborhood Hits	25
SwissProt Accessions	Q495M9, Q8N251	Gene names	USH1G, SANS
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein (Scaffold protein containing ankyrin repeats and SAM domain).

USH1G_MOUSE
θ value	θ > 10 (rank : 342)	NC score	0.051912 (rank : 212)
Query Neighborhood Hits	275	Target Neighborhood Hits	271	Shared Neighborhood Hits	25
SwissProt Accessions	Q80T11, Q80UG0	Gene names	Ush1g, Sans
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein homolog (Scaffold protein containing ankyrin repeats and SAM domain) (Jackson shaker protein).

Hits sorted by NC score

CEND3_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 4)
Query Neighborhood Hits	275	Target Neighborhood Hits	275	Shared Neighborhood Hits	275
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CEND3_MOUSE
NC score	0.988977 (rank : 2)	θ value	0 (rank : 5)
Query Neighborhood Hits	275	Target Neighborhood Hits	228	Shared Neighborhood Hits	184
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CEND2_HUMAN
NC score	0.947031 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	275	Target Neighborhood Hits	166	Shared Neighborhood Hits	112
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

CEND1_MOUSE
NC score	0.942897 (rank : 4)	θ value	0 (rank : 2)
Query Neighborhood Hits	275	Target Neighborhood Hits	260	Shared Neighborhood Hits	136
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CEND1_HUMAN
NC score	0.937539 (rank : 5)	θ value	0 (rank : 1)
Query Neighborhood Hits	275	Target Neighborhood Hits	284	Shared Neighborhood Hits	144
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

RHG09_HUMAN
NC score	0.617545 (rank : 6)	θ value	1.99529e-15 (rank : 22)
Query Neighborhood Hits	275	Target Neighborhood Hits	186	Shared Neighborhood Hits	67
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

OPHN1_MOUSE
NC score	0.592279 (rank : 7)	θ value	3.89403e-11 (rank : 51)
Query Neighborhood Hits	275	Target Neighborhood Hits	174	Shared Neighborhood Hits	71
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

GMIP_MOUSE
NC score	0.588717 (rank : 8)	θ value	1.2105e-12 (rank : 35)
Query Neighborhood Hits	275	Target Neighborhood Hits	202	Shared Neighborhood Hits	66
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

RHG06_HUMAN
NC score	0.587288 (rank : 9)	θ value	1.58096e-12 (rank : 38)
Query Neighborhood Hits	275	Target Neighborhood Hits	114	Shared Neighborhood Hits	65
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RGAP1_HUMAN
NC score	0.586761 (rank : 10)	θ value	1.58096e-12 (rank : 37)
Query Neighborhood Hits	275	Target Neighborhood Hits	189	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RHG06_MOUSE
NC score	0.586293 (rank : 11)	θ value	1.2105e-12 (rank : 36)
Query Neighborhood Hits	275	Target Neighborhood Hits	105	Shared Neighborhood Hits	61
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RGAP1_MOUSE
NC score	0.584230 (rank : 12)	θ value	1.133e-10 (rank : 56)
Query Neighborhood Hits	275	Target Neighborhood Hits	185	Shared Neighborhood Hits	61
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

GRLF1_HUMAN
NC score	0.583936 (rank : 13)	θ value	1.29331e-14 (rank : 26)
Query Neighborhood Hits	275	Target Neighborhood Hits	167	Shared Neighborhood Hits	68
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

OPHN1_HUMAN
NC score	0.582512 (rank : 14)	θ value	1.9326e-10 (rank : 58)
Query Neighborhood Hits	275	Target Neighborhood Hits	161	Shared Neighborhood Hits	69
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

RHG18_HUMAN
NC score	0.578270 (rank : 15)	θ value	2.69671e-12 (rank : 40)
Query Neighborhood Hits	275	Target Neighborhood Hits	90	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

RHG12_HUMAN
NC score	0.577671 (rank : 16)	θ value	4.16044e-13 (rank : 33)
Query Neighborhood Hits	275	Target Neighborhood Hits	190	Shared Neighborhood Hits	63
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
NC score	0.576511 (rank : 17)	θ value	5.43371e-13 (rank : 34)
Query Neighborhood Hits	275	Target Neighborhood Hits	204	Shared Neighborhood Hits	66
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

GMIP_HUMAN
NC score	0.575396 (rank : 18)	θ value	2.28291e-11 (rank : 50)
Query Neighborhood Hits	275	Target Neighborhood Hits	225	Shared Neighborhood Hits	68
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

RHG05_MOUSE
NC score	0.570062 (rank : 19)	θ value	6.85773e-16 (rank : 20)
Query Neighborhood Hits	275	Target Neighborhood Hits	165	Shared Neighborhood Hits	60
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG18_MOUSE
NC score	0.569126 (rank : 20)	θ value	2.52405e-10 (rank : 59)
Query Neighborhood Hits	275	Target Neighborhood Hits	110	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

SMP1L_HUMAN
NC score	0.566456 (rank : 21)	θ value	4.91457e-14 (rank : 27)
Query Neighborhood Hits	275	Target Neighborhood Hits	74	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

SMP1L_MOUSE
NC score	0.565810 (rank : 22)	θ value	4.91457e-14 (rank : 28)
Query Neighborhood Hits	275	Target Neighborhood Hits	70	Shared Neighborhood Hits	39
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

RHG05_HUMAN
NC score	0.565391 (rank : 23)	θ value	3.40345e-15 (rank : 23)
Query Neighborhood Hits	275	Target Neighborhood Hits	158	Shared Neighborhood Hits	60
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

TCGAP_MOUSE
NC score	0.565304 (rank : 24)	θ value	2.7842e-17 (rank : 15)
Query Neighborhood Hits	275	Target Neighborhood Hits	409	Shared Neighborhood Hits	88
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SMAP1_MOUSE
NC score	0.563424 (rank : 25)	θ value	2.69671e-12 (rank : 42)
Query Neighborhood Hits	275	Target Neighborhood Hits	120	Shared Neighborhood Hits	49
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMAP1_HUMAN
NC score	0.561820 (rank : 26)	θ value	2.69671e-12 (rank : 41)
Query Neighborhood Hits	275	Target Neighborhood Hits	98	Shared Neighborhood Hits	46
SwissProt Accessions	Q8IYB5, Q53H70, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4	Gene names	SMAP1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

3BP1_MOUSE
NC score	0.559918 (rank : 27)	θ value	4.76016e-09 (rank : 69)
Query Neighborhood Hits	275	Target Neighborhood Hits	238	Shared Neighborhood Hits	84
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

3BP1_HUMAN
NC score	0.557397 (rank : 28)	θ value	1.47974e-10 (rank : 57)
Query Neighborhood Hits	275	Target Neighborhood Hits	376	Shared Neighborhood Hits	101
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

CENA1_HUMAN
NC score	0.556922 (rank : 29)	θ value	5.08577e-11 (rank : 52)
Query Neighborhood Hits	275	Target Neighborhood Hits	87	Shared Neighborhood Hits	60
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

RHG26_HUMAN
NC score	0.549887 (rank : 30)	θ value	1.38499e-08 (rank : 72)
Query Neighborhood Hits	275	Target Neighborhood Hits	281	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

CHIO_MOUSE
NC score	0.548941 (rank : 31)	θ value	3.52202e-12 (rank : 44)
Query Neighborhood Hits	275	Target Neighborhood Hits	130	Shared Neighborhood Hits	61
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

RBP1_MOUSE
NC score	0.537532 (rank : 32)	θ value	1.02475e-11 (rank : 48)
Query Neighborhood Hits	275	Target Neighborhood Hits	493	Shared Neighborhood Hits	70
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

ABR_HUMAN
NC score	0.536194 (rank : 33)	θ value	4.16044e-13 (rank : 31)
Query Neighborhood Hits	275	Target Neighborhood Hits	166	Shared Neighborhood Hits	66
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

CENA2_HUMAN
NC score	0.531497 (rank : 34)	θ value	4.30538e-10 (rank : 60)
Query Neighborhood Hits	275	Target Neighborhood Hits	83	Shared Neighborhood Hits	57
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

CHIN_MOUSE
NC score	0.527883 (rank : 35)	θ value	3.52202e-12 (rank : 43)
Query Neighborhood Hits	275	Target Neighborhood Hits	229	Shared Neighborhood Hits	66
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

BCR_HUMAN
NC score	0.526540 (rank : 36)	θ value	1.86753e-13 (rank : 30)
Query Neighborhood Hits	275	Target Neighborhood Hits	204	Shared Neighborhood Hits	72
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

CHIN_HUMAN
NC score	0.526247 (rank : 37)	θ value	6.00763e-12 (rank : 45)
Query Neighborhood Hits	275	Target Neighborhood Hits	227	Shared Neighborhood Hits	65
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CENA2_MOUSE
NC score	0.524798 (rank : 38)	θ value	4.76016e-09 (rank : 70)
Query Neighborhood Hits	275	Target Neighborhood Hits	68	Shared Neighborhood Hits	53
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

CHIO_HUMAN
NC score	0.524247 (rank : 39)	θ value	6.00763e-12 (rank : 46)
Query Neighborhood Hits	275	Target Neighborhood Hits	220	Shared Neighborhood Hits	65
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

RBP1_HUMAN
NC score	0.523290 (rank : 40)	θ value	8.67504e-11 (rank : 54)
Query Neighborhood Hits	275	Target Neighborhood Hits	521	Shared Neighborhood Hits	70
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

TAGAP_HUMAN
NC score	0.522756 (rank : 41)	θ value	2.21117e-06 (rank : 80)
Query Neighborhood Hits	275	Target Neighborhood Hits	82	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

ARFG3_HUMAN
NC score	0.521030 (rank : 42)	θ value	1.63604e-09 (rank : 65)
Query Neighborhood Hits	275	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ARFG3_MOUSE
NC score	0.520161 (rank : 43)	θ value	5.62301e-10 (rank : 61)
Query Neighborhood Hits	275	Target Neighborhood Hits	80	Shared Neighborhood Hits	38
SwissProt Accessions	Q9D8S3, Q99KN8	Gene names	Arfgap3
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

RHG01_HUMAN
NC score	0.519559 (rank : 44)	θ value	4.92598e-06 (rank : 81)
Query Neighborhood Hits	275	Target Neighborhood Hits	75	Shared Neighborhood Hits	60
SwissProt Accessions	Q07960	Gene names	ARHGAP1, CDC42GAP, RHOGAP1
Domain Architecture
Description	Rho-GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (CDC42 GTPase-activating protein) (p50-RhoGAP).

TAGAP_MOUSE
NC score	0.519215 (rank : 45)	θ value	1.38499e-08 (rank : 74)
Query Neighborhood Hits	275	Target Neighborhood Hits	83	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

DDFL1_HUMAN
NC score	0.515320 (rank : 46)	θ value	8.65492e-19 (rank : 6)
Query Neighborhood Hits	275	Target Neighborhood Hits	353	Shared Neighborhood Hits	62
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

TCGAP_HUMAN
NC score	0.514406 (rank : 47)	θ value	2.7842e-17 (rank : 14)
Query Neighborhood Hits	275	Target Neighborhood Hits	872	Shared Neighborhood Hits	107
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

RHG07_MOUSE
NC score	0.511864 (rank : 48)	θ value	4.16044e-13 (rank : 32)
Query Neighborhood Hits	275	Target Neighborhood Hits	103	Shared Neighborhood Hits	62
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

RHG04_HUMAN
NC score	0.511458 (rank : 49)	θ value	8.67504e-11 (rank : 55)
Query Neighborhood Hits	275	Target Neighborhood Hits	307	Shared Neighborhood Hits	67
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RHG25_MOUSE
NC score	0.510373 (rank : 50)	θ value	3.41135e-07 (rank : 77)
Query Neighborhood Hits	275	Target Neighborhood Hits	492	Shared Neighborhood Hits	104
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

ARFG1_MOUSE
NC score	0.507053 (rank : 51)	θ value	2.61198e-07 (rank : 76)
Query Neighborhood Hits	275	Target Neighborhood Hits	51	Shared Neighborhood Hits	39
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

RHG07_HUMAN
NC score	0.506087 (rank : 52)	θ value	1.58096e-12 (rank : 39)
Query Neighborhood Hits	275	Target Neighborhood Hits	108	Shared Neighborhood Hits	60
SwissProt Accessions	Q96QB1, O14868, O43199, Q9C0E0	Gene names	DLC1, ARHGAP7, KIAA1723, STARD12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

ARFG1_HUMAN
NC score	0.494471 (rank : 53)	θ value	5.81887e-07 (rank : 78)
Query Neighborhood Hits	275	Target Neighborhood Hits	60	Shared Neighborhood Hits	40
SwissProt Accessions	Q8N6T3, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0	Gene names	ARFGAP1, ARF1GAP
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

SRGP2_HUMAN
NC score	0.492778 (rank : 54)	θ value	3.64472e-09 (rank : 67)
Query Neighborhood Hits	275	Target Neighborhood Hits	331	Shared Neighborhood Hits	68
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

DDFL1_MOUSE
NC score	0.492531 (rank : 55)	θ value	3.28887e-18 (rank : 8)
Query Neighborhood Hits	275	Target Neighborhood Hits	324	Shared Neighborhood Hits	59
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

CENG1_MOUSE
NC score	0.488365 (rank : 56)	θ value	9.56915e-18 (rank : 10)
Query Neighborhood Hits	275	Target Neighborhood Hits	531	Shared Neighborhood Hits	71
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

SRGP2_MOUSE
NC score	0.486230 (rank : 57)	θ value	1.38499e-08 (rank : 73)
Query Neighborhood Hits	275	Target Neighborhood Hits	324	Shared Neighborhood Hits	68
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

RHG08_MOUSE
NC score	0.485125 (rank : 58)	θ value	0.00102713 (rank : 92)
Query Neighborhood Hits	275	Target Neighborhood Hits	73	Shared Neighborhood Hits	60
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

CENB5_HUMAN
NC score	0.484943 (rank : 59)	θ value	1.058e-16 (rank : 16)
Query Neighborhood Hits	275	Target Neighborhood Hits	395	Shared Neighborhood Hits	70
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

FNBP2_HUMAN
NC score	0.483956 (rank : 60)	θ value	8.67504e-11 (rank : 53)
Query Neighborhood Hits	275	Target Neighborhood Hits	432	Shared Neighborhood Hits	74
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

CENB1_HUMAN
NC score	0.483365 (rank : 61)	θ value	6.41864e-14 (rank : 29)
Query Neighborhood Hits	275	Target Neighborhood Hits	383	Shared Neighborhood Hits	72
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

RHG08_HUMAN
NC score	0.483054 (rank : 62)	θ value	0.000461057 (rank : 86)
Query Neighborhood Hits	275	Target Neighborhood Hits	88	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NSG0, O75983, O95695, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NVX8, Q9NXL1, Q9UH20	Gene names	ARHGAP8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

CENG1_HUMAN
NC score	0.482573 (rank : 63)	θ value	1.24977e-17 (rank : 12)
Query Neighborhood Hits	275	Target Neighborhood Hits	544	Shared Neighborhood Hits	69
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

DDEF1_MOUSE
NC score	0.482284 (rank : 64)	θ value	4.44505e-15 (rank : 24)
Query Neighborhood Hits	275	Target Neighborhood Hits	592	Shared Neighborhood Hits	75
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

CENB2_HUMAN
NC score	0.481171 (rank : 65)	θ value	1.80466e-16 (rank : 18)
Query Neighborhood Hits	275	Target Neighborhood Hits	425	Shared Neighborhood Hits	75
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

SRGP1_HUMAN
NC score	0.481066 (rank : 66)	θ value	4.0297e-08 (rank : 75)
Query Neighborhood Hits	275	Target Neighborhood Hits	390	Shared Neighborhood Hits	70
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

DDEF2_HUMAN
NC score	0.476871 (rank : 67)	θ value	1.99529e-15 (rank : 21)
Query Neighborhood Hits	275	Target Neighborhood Hits	599	Shared Neighborhood Hits	82
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

STA13_HUMAN
NC score	0.475740 (rank : 68)	θ value	1.63604e-09 (rank : 66)
Query Neighborhood Hits	275	Target Neighborhood Hits	89	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

DDEF2_MOUSE
NC score	0.473795 (rank : 69)	θ value	4.44505e-15 (rank : 25)
Query Neighborhood Hits	275	Target Neighborhood Hits	625	Shared Neighborhood Hits	86
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

STA13_MOUSE
NC score	0.473536 (rank : 70)	θ value	5.62301e-10 (rank : 62)
Query Neighborhood Hits	275	Target Neighborhood Hits	89	Shared Neighborhood Hits	58
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

CENG3_HUMAN
NC score	0.471707 (rank : 71)	θ value	1.92812e-18 (rank : 7)
Query Neighborhood Hits	275	Target Neighborhood Hits	455	Shared Neighborhood Hits	50
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_MOUSE
NC score	0.471534 (rank : 72)	θ value	4.29542e-18 (rank : 9)
Query Neighborhood Hits	275	Target Neighborhood Hits	467	Shared Neighborhood Hits	49
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

RHG25_HUMAN
NC score	0.470805 (rank : 73)	θ value	5.81887e-07 (rank : 79)
Query Neighborhood Hits	275	Target Neighborhood Hits	550	Shared Neighborhood Hits	100
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

STAR8_MOUSE
NC score	0.464689 (rank : 74)	θ value	3.64472e-09 (rank : 68)
Query Neighborhood Hits	275	Target Neighborhood Hits	101	Shared Neighborhood Hits	58
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STAR8_HUMAN
NC score	0.463130 (rank : 75)	θ value	6.21693e-09 (rank : 71)
Query Neighborhood Hits	275	Target Neighborhood Hits	216	Shared Neighborhood Hits	69
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

CENG2_MOUSE
NC score	0.450313 (rank : 76)	θ value	1.058e-16 (rank : 17)
Query Neighborhood Hits	275	Target Neighborhood Hits	463	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

CENG2_HUMAN
NC score	0.448116 (rank : 77)	θ value	1.80466e-16 (rank : 19)
Query Neighborhood Hits	275	Target Neighborhood Hits	471	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

GIT2_HUMAN
NC score	0.438674 (rank : 78)	θ value	2.28291e-11 (rank : 49)
Query Neighborhood Hits	275	Target Neighborhood Hits	381	Shared Neighborhood Hits	47
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

GIT2_MOUSE
NC score	0.438639 (rank : 79)	θ value	1.02475e-11 (rank : 47)
Query Neighborhood Hits	275	Target Neighborhood Hits	323	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

GIT1_HUMAN
NC score	0.425967 (rank : 80)	θ value	7.34386e-10 (rank : 63)
Query Neighborhood Hits	275	Target Neighborhood Hits	336	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

GIT1_MOUSE
NC score	0.424584 (rank : 81)	θ value	7.34386e-10 (rank : 64)
Query Neighborhood Hits	275	Target Neighborhood Hits	341	Shared Neighborhood Hits	44
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

CE005_HUMAN
NC score	0.419789 (rank : 82)	θ value	0.00102713 (rank : 90)
Query Neighborhood Hits	275	Target Neighborhood Hits	213	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

CE005_MOUSE
NC score	0.415390 (rank : 83)	θ value	0.00869519 (rank : 104)
Query Neighborhood Hits	275	Target Neighborhood Hits	238	Shared Neighborhood Hits	63
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

NUPL_HUMAN
NC score	0.371707 (rank : 84)	θ value	0.000121331 (rank : 82)
Query Neighborhood Hits	275	Target Neighborhood Hits	68	Shared Neighborhood Hits	38
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).

NUPL_MOUSE
NC score	0.368250 (rank : 85)	θ value	0.000121331 (rank : 83)
Query Neighborhood Hits	275	Target Neighborhood Hits	113	Shared Neighborhood Hits	41
SwissProt Accessions	Q8K2K6, O70448, Q8BQL5, Q8CDK9	Gene names	Hrb, Rip
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein homolog).

HRBL_HUMAN
NC score	0.329650 (rank : 86)	θ value	0.000786445 (rank : 87)
Query Neighborhood Hits	275	Target Neighborhood Hits	179	Shared Neighborhood Hits	55
SwissProt Accessions	O95081, O75429, Q96AB9, Q96GL4	Gene names	HRBL, RABR
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

MYO9B_MOUSE
NC score	0.323795 (rank : 87)	θ value	9.56915e-18 (rank : 11)
Query Neighborhood Hits	275	Target Neighborhood Hits	311	Shared Neighborhood Hits	70
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

MYO9B_HUMAN
NC score	0.323301 (rank : 88)	θ value	1.24977e-17 (rank : 13)
Query Neighborhood Hits	275	Target Neighborhood Hits	641	Shared Neighborhood Hits	92
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

HRBL_MOUSE
NC score	0.315839 (rank : 89)	θ value	0.000786445 (rank : 88)
Query Neighborhood Hits	275	Target Neighborhood Hits	269	Shared Neighborhood Hits	55
SwissProt Accessions	Q80WC7, Q8BKS5, Q99J67	Gene names	Hrbl, Rabr
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

K1688_MOUSE
NC score	0.308949 (rank : 90)	θ value	0.365318 (rank : 151)
Query Neighborhood Hits	275	Target Neighborhood Hits	188	Shared Neighborhood Hits	76
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

K1688_HUMAN
NC score	0.299696 (rank : 91)	θ value	1.06291 (rank : 177)
Query Neighborhood Hits	275	Target Neighborhood Hits	217	Shared Neighborhood Hits	74
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

P85A_HUMAN
NC score	0.273397 (rank : 92)	θ value	0.00390308 (rank : 99)
Query Neighborhood Hits	275	Target Neighborhood Hits	479	Shared Neighborhood Hits	68
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
NC score	0.267625 (rank : 93)	θ value	0.00390308 (rank : 100)
Query Neighborhood Hits	275	Target Neighborhood Hits	435	Shared Neighborhood Hits	68
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

PKHA1_HUMAN
NC score	0.224702 (rank : 94)	θ value	0.000270298 (rank : 84)
Query Neighborhood Hits	275	Target Neighborhood Hits	127	Shared Neighborhood Hits	48
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
NC score	0.217885 (rank : 95)	θ value	0.000786445 (rank : 89)
Query Neighborhood Hits	275	Target Neighborhood Hits	120	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_MOUSE
NC score	0.185185 (rank : 96)	θ value	0.00228821 (rank : 97)
Query Neighborhood Hits	275	Target Neighborhood Hits	116	Shared Neighborhood Hits	41
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

OCRL_HUMAN
NC score	0.171173 (rank : 97)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	275	Target Neighborhood Hits	77	Shared Neighborhood Hits	51
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).

I5P2_HUMAN
NC score	0.167990 (rank : 98)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	275	Target Neighborhood Hits	86	Shared Neighborhood Hits	50
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

PKHA6_MOUSE
NC score	0.161971 (rank : 99)	θ value	0.0330416 (rank : 115)
Query Neighborhood Hits	275	Target Neighborhood Hits	591	Shared Neighborhood Hits	68
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA2_HUMAN
NC score	0.161017 (rank : 100)	θ value	0.125558 (rank : 136)
Query Neighborhood Hits	275	Target Neighborhood Hits	119	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHA6_HUMAN
NC score	0.160170 (rank : 101)	θ value	0.163984 (rank : 140)
Query Neighborhood Hits	275	Target Neighborhood Hits	556	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

DGKH_HUMAN
NC score	0.133398 (rank : 102)	θ value	0.00134147 (rank : 94)
Query Neighborhood Hits	275	Target Neighborhood Hits	255	Shared Neighborhood Hits	71
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

DGKD_HUMAN
NC score	0.117115 (rank : 103)	θ value	0.00665767 (rank : 103)
Query Neighborhood Hits	275	Target Neighborhood Hits	231	Shared Neighborhood Hits	60
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

PKHA4_MOUSE
NC score	0.108422 (rank : 104)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	275	Target Neighborhood Hits	202	Shared Neighborhood Hits	47
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

CSKI2_MOUSE
NC score	0.106947 (rank : 105)	θ value	0.0431538 (rank : 117)
Query Neighborhood Hits	275	Target Neighborhood Hits	812	Shared Neighborhood Hits	111
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CSKI2_HUMAN
NC score	0.106215 (rank : 106)	θ value	0.0563607 (rank : 118)
Query Neighborhood Hits	275	Target Neighborhood Hits	747	Shared Neighborhood Hits	108
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CSKI1_HUMAN
NC score	0.102880 (rank : 107)	θ value	0.00665767 (rank : 102)
Query Neighborhood Hits	275	Target Neighborhood Hits	997	Shared Neighborhood Hits	122
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

PKHA4_HUMAN
NC score	0.102818 (rank : 108)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	275	Target Neighborhood Hits	283	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

CSKI1_MOUSE
NC score	0.099085 (rank : 109)	θ value	0.125558 (rank : 131)
Query Neighborhood Hits	275	Target Neighborhood Hits	1031	Shared Neighborhood Hits	117
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

DP13A_HUMAN
NC score	0.095966 (rank : 110)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	275	Target Neighborhood Hits	107	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13A_MOUSE
NC score	0.093306 (rank : 111)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	275	Target Neighborhood Hits	96	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K3H0, Q3UJP7, Q69ZJ9, Q8BWZ8, Q8VCJ8, Q9CUW4	Gene names	Appl1, Dip13a, Kiaa1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DAPP1_MOUSE
NC score	0.092758 (rank : 112)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	275	Target Neighborhood Hits	225	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PKHA5_HUMAN
NC score	0.091939 (rank : 113)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	275	Target Neighborhood Hits	455	Shared Neighborhood Hits	51
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

DP13B_MOUSE
NC score	0.091372 (rank : 114)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	275	Target Neighborhood Hits	58	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

CYH1_MOUSE
NC score	0.091058 (rank : 115)	θ value	0.365318 (rank : 149)
Query Neighborhood Hits	275	Target Neighborhood Hits	176	Shared Neighborhood Hits	44
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

DAPP1_HUMAN
NC score	0.090745 (rank : 116)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	275	Target Neighborhood Hits	227	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

CYH1_HUMAN
NC score	0.090093 (rank : 117)	θ value	0.365318 (rank : 148)
Query Neighborhood Hits	275	Target Neighborhood Hits	184	Shared Neighborhood Hits	43
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH2_HUMAN
NC score	0.087342 (rank : 118)	θ value	0.163984 (rank : 137)
Query Neighborhood Hits	275	Target Neighborhood Hits	175	Shared Neighborhood Hits	45
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
NC score	0.087183 (rank : 119)	θ value	0.163984 (rank : 138)
Query Neighborhood Hits	275	Target Neighborhood Hits	171	Shared Neighborhood Hits	44
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

DP13B_HUMAN
NC score	0.085962 (rank : 120)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	275	Target Neighborhood Hits	58	Shared Neighborhood Hits	20
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

CYH3_HUMAN
NC score	0.085066 (rank : 121)	θ value	0.365318 (rank : 150)
Query Neighborhood Hits	275	Target Neighborhood Hits	137	Shared Neighborhood Hits	42
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

TNKS1_HUMAN
NC score	0.084343 (rank : 122)	θ value	0.00102713 (rank : 93)
Query Neighborhood Hits	275	Target Neighborhood Hits	477	Shared Neighborhood Hits	68
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

CNKR1_HUMAN
NC score	0.083945 (rank : 123)	θ value	0.365318 (rank : 147)
Query Neighborhood Hits	275	Target Neighborhood Hits	154	Shared Neighborhood Hits	47
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CT086_HUMAN
NC score	0.082361 (rank : 124)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	275	Target Neighborhood Hits	277	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BZ19, Q4VXE6	Gene names	C20orf86
Domain Architecture
Description	Putative uncharacterized protein C20orf86.

3BP2_HUMAN
NC score	0.080452 (rank : 125)	θ value	2.36792 (rank : 197)
Query Neighborhood Hits	275	Target Neighborhood Hits	296	Shared Neighborhood Hits	56
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

PLEK_HUMAN
NC score	0.078000 (rank : 126)	θ value	4.03905 (rank : 229)
Query Neighborhood Hits	275	Target Neighborhood Hits	110	Shared Neighborhood Hits	42
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

CYH3_MOUSE
NC score	0.077807 (rank : 127)	θ value	1.38821 (rank : 179)
Query Neighborhood Hits	275	Target Neighborhood Hits	148	Shared Neighborhood Hits	41
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

EPHB6_HUMAN
NC score	0.077104 (rank : 128)	θ value	0.163984 (rank : 139)
Query Neighborhood Hits	275	Target Neighborhood Hits	912	Shared Neighborhood Hits	46
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

EPHB6_MOUSE
NC score	0.076422 (rank : 129)	θ value	0.21417 (rank : 143)
Query Neighborhood Hits	275	Target Neighborhood Hits	906	Shared Neighborhood Hits	45
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

MYO10_HUMAN
NC score	0.076050 (rank : 130)	θ value	0.125558 (rank : 134)
Query Neighborhood Hits	275	Target Neighborhood Hits	920	Shared Neighborhood Hits	66
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

TNKS2_HUMAN
NC score	0.075720 (rank : 131)	θ value	0.0113563 (rank : 109)
Query Neighborhood Hits	275	Target Neighborhood Hits	361	Shared Neighborhood Hits	40
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

GAB2_MOUSE
NC score	0.072201 (rank : 132)	θ value	6.88961 (rank : 252)
Query Neighborhood Hits	275	Target Neighborhood Hits	220	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

BAT2_MOUSE
NC score	0.071582 (rank : 133)	θ value	0.0148317 (rank : 110)
Query Neighborhood Hits	275	Target Neighborhood Hits	947	Shared Neighborhood Hits	77
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

ANR37_MOUSE
NC score	0.070779 (rank : 134)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	275	Target Neighborhood Hits	237	Shared Neighborhood Hits	23
SwissProt Accessions	Q569N2, Q8CHS0	Gene names	Ankrd37
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37.

EPHA6_HUMAN
NC score	0.070774 (rank : 135)	θ value	0.0252991 (rank : 113)
Query Neighborhood Hits	275	Target Neighborhood Hits	959	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

CYH4_MOUSE
NC score	0.069793 (rank : 136)	θ value	4.03905 (rank : 223)
Query Neighborhood Hits	275	Target Neighborhood Hits	134	Shared Neighborhood Hits	41
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

ANR41_HUMAN
NC score	0.069740 (rank : 137)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	275	Target Neighborhood Hits	332	Shared Neighborhood Hits	26
SwissProt Accessions	Q8NAG6, Q8N8J8	Gene names	ANKRD41
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 41.

EPHA4_HUMAN
NC score	0.069453 (rank : 138)	θ value	0.0113563 (rank : 105)
Query Neighborhood Hits	275	Target Neighborhood Hits	975	Shared Neighborhood Hits	47
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

3BP2_MOUSE
NC score	0.069203 (rank : 139)	θ value	6.88961 (rank : 242)
Query Neighborhood Hits	275	Target Neighborhood Hits	142	Shared Neighborhood Hits	48
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

CYH4_HUMAN
NC score	0.069088 (rank : 140)	θ value	2.36792 (rank : 203)
Query Neighborhood Hits	275	Target Neighborhood Hits	135	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

EPHA1_MOUSE
NC score	0.068929 (rank : 141)	θ value	0.00102713 (rank : 91)
Query Neighborhood Hits	275	Target Neighborhood Hits	958	Shared Neighborhood Hits	48
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHA6_MOUSE
NC score	0.068525 (rank : 142)	θ value	1.81305 (rank : 190)
Query Neighborhood Hits	275	Target Neighborhood Hits	946	Shared Neighborhood Hits	46
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA8_MOUSE
NC score	0.068415 (rank : 143)	θ value	0.00035302 (rank : 85)
Query Neighborhood Hits	275	Target Neighborhood Hits	969	Shared Neighborhood Hits	48
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHA4_MOUSE
NC score	0.068105 (rank : 144)	θ value	0.0193708 (rank : 111)
Query Neighborhood Hits	275	Target Neighborhood Hits	982	Shared Neighborhood Hits	48
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

GAB2_HUMAN
NC score	0.067061 (rank : 145)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	275	Target Neighborhood Hits	188	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

EPHA1_HUMAN
NC score	0.066834 (rank : 146)	θ value	0.00390308 (rank : 98)
Query Neighborhood Hits	275	Target Neighborhood Hits	997	Shared Neighborhood Hits	44
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

BAT2_HUMAN
NC score	0.066586 (rank : 147)	θ value	0.0961366 (rank : 127)
Query Neighborhood Hits	275	Target Neighborhood Hits	931	Shared Neighborhood Hits	74
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

IASPP_MOUSE
NC score	0.066581 (rank : 148)	θ value	1.06291 (rank : 176)
Query Neighborhood Hits	275	Target Neighborhood Hits	1024	Shared Neighborhood Hits	79
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

EPHA8_HUMAN
NC score	0.066269 (rank : 149)	θ value	0.00175202 (rank : 95)
Query Neighborhood Hits	275	Target Neighborhood Hits	956	Shared Neighborhood Hits	46
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHA5_HUMAN
NC score	0.066244 (rank : 150)	θ value	0.00228821 (rank : 96)
Query Neighborhood Hits	275	Target Neighborhood Hits	1009	Shared Neighborhood Hits	53
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHAA_HUMAN
NC score	0.065701 (rank : 151)	θ value	0.62314 (rank : 158)
Query Neighborhood Hits	275	Target Neighborhood Hits	960	Shared Neighborhood Hits	47
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

ANR46_HUMAN
NC score	0.065647 (rank : 152)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	275	Target Neighborhood Hits	281	Shared Neighborhood Hits	24
SwissProt Accessions	Q86W74, Q6P9B7	Gene names	ANKRD46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

EPHA7_HUMAN
NC score	0.065296 (rank : 153)	θ value	0.00509761 (rank : 101)
Query Neighborhood Hits	275	Target Neighborhood Hits	1053	Shared Neighborhood Hits	51
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

ANR39_MOUSE
NC score	0.064972 (rank : 154)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	275	Target Neighborhood Hits	284	Shared Neighborhood Hits	25
SwissProt Accessions	Q9D2X0	Gene names	Ankrd39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ANR46_MOUSE
NC score	0.064903 (rank : 155)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	275	Target Neighborhood Hits	274	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BTZ5, Q1LZK9, Q8BV97	Gene names	Ankrd46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

SASH1_HUMAN
NC score	0.064646 (rank : 156)	θ value	0.813845 (rank : 170)
Query Neighborhood Hits	275	Target Neighborhood Hits	292	Shared Neighborhood Hits	54
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

EPHA7_MOUSE
NC score	0.064465 (rank : 157)	θ value	0.0113563 (rank : 106)
Query Neighborhood Hits	275	Target Neighborhood Hits	1025	Shared Neighborhood Hits	48
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHB2_HUMAN
NC score	0.064155 (rank : 158)	θ value	0.0563607 (rank : 120)
Query Neighborhood Hits	275	Target Neighborhood Hits	983	Shared Neighborhood Hits	49
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

ANR39_HUMAN
NC score	0.064116 (rank : 159)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	275	Target Neighborhood Hits	285	Shared Neighborhood Hits	25
SwissProt Accessions	Q53RE8, Q59FU2, Q8N5X5, Q9P0S5	Gene names	ANKRD39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

EPHB1_HUMAN
NC score	0.063815 (rank : 160)	θ value	0.0113563 (rank : 107)
Query Neighborhood Hits	275	Target Neighborhood Hits	988	Shared Neighborhood Hits	49
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

EPHB2_MOUSE
NC score	0.063647 (rank : 161)	θ value	0.0563607 (rank : 121)
Query Neighborhood Hits	275	Target Neighborhood Hits	982	Shared Neighborhood Hits	49
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHA2_MOUSE
NC score	0.063395 (rank : 162)	θ value	0.0330416 (rank : 114)
Query Neighborhood Hits	275	Target Neighborhood Hits	1020	Shared Neighborhood Hits	48
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

SHAN1_HUMAN
NC score	0.062811 (rank : 163)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	275	Target Neighborhood Hits	1041	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

EPHA2_HUMAN
NC score	0.062786 (rank : 164)	θ value	0.0736092 (rank : 124)
Query Neighborhood Hits	275	Target Neighborhood Hits	1021	Shared Neighborhood Hits	48
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHB3_HUMAN
NC score	0.062641 (rank : 165)	θ value	0.0961366 (rank : 128)
Query Neighborhood Hits	275	Target Neighborhood Hits	996	Shared Neighborhood Hits	49
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

IKBB_MOUSE
NC score	0.062406 (rank : 166)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	275	Target Neighborhood Hits	284	Shared Neighborhood Hits	25
SwissProt Accessions	Q60778, Q9D6L5	Gene names	Nfkbib, Ikbb
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B).

PLEK_MOUSE
NC score	0.062301 (rank : 167)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	275	Target Neighborhood Hits	109	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

SASH1_MOUSE
NC score	0.061965 (rank : 168)	θ value	4.03905 (rank : 230)
Query Neighborhood Hits	275	Target Neighborhood Hits	263	Shared Neighborhood Hits	55
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

EPHB3_MOUSE
NC score	0.061622 (rank : 169)	θ value	0.21417 (rank : 142)
Query Neighborhood Hits	275	Target Neighborhood Hits	996	Shared Neighborhood Hits	48
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

ANR37_HUMAN
NC score	0.061114 (rank : 170)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	275	Target Neighborhood Hits	247	Shared Neighborhood Hits	22
SwissProt Accessions	Q7Z713	Gene names	ANKRD37, LPR2BP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37 (Low-density lipoprotein receptor-related protein 2-binding protein) (hLrp2bp).

PLEK2_HUMAN
NC score	0.061001 (rank : 171)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	275	Target Neighborhood Hits	101	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

CNKR2_MOUSE
NC score	0.060726 (rank : 172)	θ value	2.36792 (rank : 202)
Query Neighborhood Hits	275	Target Neighborhood Hits	197	Shared Neighborhood Hits	42
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

GABP3_MOUSE
NC score	0.060686 (rank : 173)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	275	Target Neighborhood Hits	330	Shared Neighborhood Hits	25
SwissProt Accessions	P81069	Gene names	Gabpb2
Domain Architecture	No domain graphic available
Description	GA-binding protein beta-2-1 chain (GABP subunit beta-2-1) (GABPB2-1).

EPHB4_MOUSE
NC score	0.060567 (rank : 174)	θ value	0.0736092 (rank : 125)
Query Neighborhood Hits	275	Target Neighborhood Hits	1013	Shared Neighborhood Hits	48
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

CNKR2_HUMAN
NC score	0.060394 (rank : 175)	θ value	2.36792 (rank : 201)
Query Neighborhood Hits	275	Target Neighborhood Hits	197	Shared Neighborhood Hits	42
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

EPHB4_HUMAN
NC score	0.060007 (rank : 176)	θ value	0.0961366 (rank : 129)
Query Neighborhood Hits	275	Target Neighborhood Hits	1056	Shared Neighborhood Hits	48
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

ANS4B_MOUSE
NC score	0.059669 (rank : 177)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	275	Target Neighborhood Hits	294	Shared Neighborhood Hits	24
SwissProt Accessions	Q8K3X6, Q9D8A5	Gene names	Anks4b, Harp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

IASPP_HUMAN
NC score	0.059619 (rank : 178)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	275	Target Neighborhood Hits	688	Shared Neighborhood Hits	64
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

P85B_HUMAN
NC score	0.059300 (rank : 179)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	275	Target Neighborhood Hits	543	Shared Neighborhood Hits	39
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PLEK2_MOUSE
NC score	0.059199 (rank : 180)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	275	Target Neighborhood Hits	96	Shared Neighborhood Hits	34
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

ANKS1_MOUSE
NC score	0.059193 (rank : 181)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	275	Target Neighborhood Hits	453	Shared Neighborhood Hits	66
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

GABP2_HUMAN
NC score	0.058554 (rank : 182)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	275	Target Neighborhood Hits	454	Shared Neighborhood Hits	27
SwissProt Accessions	Q06547, Q06545, Q12940, Q12941, Q12942, Q8IYD0	Gene names	GABPB2, E4TF1B, GABPB, GABPB1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1) (Transcription factor E4TF1-53) (Transcription factor E4TF1-47) (Nuclear respiratory factor 2).

GABP2_MOUSE
NC score	0.058316 (rank : 183)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	275	Target Neighborhood Hits	429	Shared Neighborhood Hits	26
SwissProt Accessions	Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2	Gene names	Gabpb2, Gabpb, Gabpb1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1).

HSF1_MOUSE
NC score	0.056924 (rank : 184)	θ value	0.21417 (rank : 144)
Query Neighborhood Hits	275	Target Neighborhood Hits	267	Shared Neighborhood Hits	27
SwissProt Accessions	P38532, O70462	Gene names	Hsf1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

GAB1_HUMAN
NC score	0.056835 (rank : 185)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	275	Target Neighborhood Hits	279	Shared Neighborhood Hits	41
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

ILK2_HUMAN
NC score	0.056472 (rank : 186)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	275	Target Neighborhood Hits	848	Shared Neighborhood Hits	53
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

RAPH1_HUMAN
NC score	0.056240 (rank : 187)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	275	Target Neighborhood Hits	593	Shared Neighborhood Hits	80
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

DGKK_HUMAN
NC score	0.056216 (rank : 188)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	275	Target Neighborhood Hits	378	Shared Neighborhood Hits	62
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

SHAN2_MOUSE
NC score	0.056202 (rank : 189)	θ value	0.62314 (rank : 162)
Query Neighborhood Hits	275	Target Neighborhood Hits	446	Shared Neighborhood Hits	58
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

EPHA5_MOUSE
NC score	0.055629 (rank : 190)	θ value	0.0563607 (rank : 119)
Query Neighborhood Hits	275	Target Neighborhood Hits	950	Shared Neighborhood Hits	48
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

ILK1_HUMAN
NC score	0.055555 (rank : 191)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	275	Target Neighborhood Hits	857	Shared Neighborhood Hits	53
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

MTPN_MOUSE
NC score	0.055496 (rank : 192)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	275	Target Neighborhood Hits	269	Shared Neighborhood Hits	23
SwissProt Accessions	P62774, P80144, Q543M6, Q9DCN8	Gene names	Mtpn, Gcdp
Domain Architecture	No domain graphic available
Description	Myotrophin (Protein V-1) (Granule cell differentiation protein).

ANS4B_HUMAN
NC score	0.055164 (rank : 193)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	275	Target Neighborhood Hits	289	Shared Neighborhood Hits	23
SwissProt Accessions	Q8N8V4	Gene names	ANKS4B, HARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

IKBB_HUMAN
NC score	0.055012 (rank : 194)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	275	Target Neighborhood Hits	284	Shared Neighborhood Hits	25
SwissProt Accessions	Q15653, Q96BJ7	Gene names	NFKBIB, IKBB, TRIP9
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9).

ILK_MOUSE
NC score	0.054809 (rank : 195)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	275	Target Neighborhood Hits	858	Shared Neighborhood Hits	54
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ANKS1_HUMAN
NC score	0.054743 (rank : 196)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	275	Target Neighborhood Hits	438	Shared Neighborhood Hits	64
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

MYPT1_MOUSE
NC score	0.054199 (rank : 197)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	275	Target Neighborhood Hits	539	Shared Neighborhood Hits	32
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

MTPN_HUMAN
NC score	0.053939 (rank : 198)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	275	Target Neighborhood Hits	269	Shared Neighborhood Hits	23
SwissProt Accessions	P58546	Gene names	MTPN
Domain Architecture
Description	Myotrophin (Protein V-1).

K1543_MOUSE
NC score	0.053737 (rank : 199)	θ value	0.62314 (rank : 160)
Query Neighborhood Hits	275	Target Neighborhood Hits	497	Shared Neighborhood Hits	51
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

ANK2_HUMAN
NC score	0.053577 (rank : 200)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	275	Target Neighborhood Hits	1615	Shared Neighborhood Hits	87
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

ANR42_HUMAN
NC score	0.053535 (rank : 201)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	275	Target Neighborhood Hits	284	Shared Neighborhood Hits	25
SwissProt Accessions	Q8N9B4, Q49A49	Gene names	ANKRD42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

ANKR6_HUMAN
NC score	0.053302 (rank : 202)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	275	Target Neighborhood Hits	439	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y2G4, Q9NU24, Q9UFQ9	Gene names	ANKRD6, KIAA0957
Domain Architecture
Description	Ankyrin repeat domain-containing protein 6.

TROAP_HUMAN
NC score	0.053192 (rank : 203)	θ value	0.0330416 (rank : 116)
Query Neighborhood Hits	275	Target Neighborhood Hits	258	Shared Neighborhood Hits	27
SwissProt Accessions	Q12815	Gene names	TROAP
Domain Architecture	No domain graphic available
Description	Trophinin-associated protein (Tastin) (Trophinin-assisting protein).

CDN2D_HUMAN
NC score	0.053094 (rank : 204)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	275	Target Neighborhood Hits	268	Shared Neighborhood Hits	20
SwissProt Accessions	P55273, Q13102, Q6FGE9	Gene names	CDKN2D
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

ANR10_HUMAN
NC score	0.053070 (rank : 205)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	275	Target Neighborhood Hits	289	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NXR5	Gene names	ANKRD10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

EPHA3_MOUSE
NC score	0.052809 (rank : 206)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	275	Target Neighborhood Hits	1009	Shared Neighborhood Hits	42
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

ASB10_HUMAN
NC score	0.052761 (rank : 207)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	275	Target Neighborhood Hits	291	Shared Neighborhood Hits	25
SwissProt Accessions	Q8WXI3	Gene names	ASB10
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

MYPT1_HUMAN
NC score	0.052516 (rank : 208)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	275	Target Neighborhood Hits	723	Shared Neighborhood Hits	34
SwissProt Accessions	O14974, Q86WU3, Q8NFR6, Q9BYH0	Gene names	PPP1R12A, MBS, MYPT1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit).

EPHA3_HUMAN
NC score	0.052218 (rank : 209)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	275	Target Neighborhood Hits	1005	Shared Neighborhood Hits	41
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

ANKR2_HUMAN
NC score	0.052156 (rank : 210)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	275	Target Neighborhood Hits	321	Shared Neighborhood Hits	25
SwissProt Accessions	Q9GZV1, Q5T456, Q8WUD7	Gene names	ANKRD2, ARPP
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp).

ANK1_MOUSE
NC score	0.052025 (rank : 211)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	275	Target Neighborhood Hits	430	Shared Neighborhood Hits	31
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

USH1G_MOUSE
NC score	0.051912 (rank : 212)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	275	Target Neighborhood Hits	271	Shared Neighborhood Hits	25
SwissProt Accessions	Q80T11, Q80UG0	Gene names	Ush1g, Sans
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein homolog (Scaffold protein containing ankyrin repeats and SAM domain) (Jackson shaker protein).

HECD1_HUMAN
NC score	0.051834 (rank : 213)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	275	Target Neighborhood Hits	371	Shared Neighborhood Hits	24
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

ANK1_HUMAN
NC score	0.051795 (rank : 214)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	275	Target Neighborhood Hits	416	Shared Neighborhood Hits	27
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

USH1G_HUMAN
NC score	0.051730 (rank : 215)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	275	Target Neighborhood Hits	267	Shared Neighborhood Hits	25
SwissProt Accessions	Q495M9, Q8N251	Gene names	USH1G, SANS
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein (Scaffold protein containing ankyrin repeats and SAM domain).

SHAN2_HUMAN
NC score	0.051583 (rank : 216)	θ value	2.36792 (rank : 212)
Query Neighborhood Hits	275	Target Neighborhood Hits	346	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

FARP1_HUMAN
NC score	0.051292 (rank : 217)	θ value	0.125558 (rank : 132)
Query Neighborhood Hits	275	Target Neighborhood Hits	241	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

ASB10_MOUSE
NC score	0.050979 (rank : 218)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	275	Target Neighborhood Hits	301	Shared Neighborhood Hits	25
SwissProt Accessions	Q91ZT7	Gene names	Asb10
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

ANR10_MOUSE
NC score	0.050906 (rank : 219)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	275	Target Neighborhood Hits	273	Shared Neighborhood Hits	25
SwissProt Accessions	Q99LW0	Gene names	Ankrd10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

ANR52_MOUSE
NC score	0.050776 (rank : 220)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	275	Target Neighborhood Hits	318	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BTI7	Gene names	Ankrd52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

PSD10_HUMAN
NC score	0.050771 (rank : 221)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	275	Target Neighborhood Hits	301	Shared Neighborhood Hits	25
SwissProt Accessions	O75832	Gene names	PSMD10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

ANR52_HUMAN
NC score	0.050714 (rank : 222)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	275	Target Neighborhood Hits	322	Shared Neighborhood Hits	25
SwissProt Accessions	Q8NB46	Gene names	ANKRD52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ANR33_HUMAN
NC score	0.050639 (rank : 223)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	275	Target Neighborhood Hits	215	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z3H0, Q5K619, Q5K621, Q5K622, Q5K623, Q5K624, Q6ZUN0	Gene names	ANKRD33, C12orf7
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

PCTL_MOUSE
NC score	0.050554 (rank : 224)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	275	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JMD3	Gene names	Stard10, Pctpl, Sdccag28, Sdccagg28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28 homolog).

MTMRD_HUMAN
NC score	0.050429 (rank : 225)	θ value	0.125558 (rank : 133)
Query Neighborhood Hits	275	Target Neighborhood Hits	135	Shared Neighborhood Hits	34
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

ANR22_HUMAN
NC score	0.050411 (rank : 226)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	275	Target Neighborhood Hits	243	Shared Neighborhood Hits	17
SwissProt Accessions	Q5VYY1, Q8WU06	Gene names	ANKRD22
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 22.

K0310_HUMAN
NC score	0.049446 (rank : 227)	θ value	0.0563607 (rank : 122)
Query Neighborhood Hits	275	Target Neighborhood Hits	420	Shared Neighborhood Hits	35
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

MDC1_MOUSE
NC score	0.048607 (rank : 228)	θ value	0.365318 (rank : 152)
Query Neighborhood Hits	275	Target Neighborhood Hits	998	Shared Neighborhood Hits	66
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

SON_HUMAN
NC score	0.046967 (rank : 229)	θ value	0.365318 (rank : 154)
Query Neighborhood Hits	275	Target Neighborhood Hits	1568	Shared Neighborhood Hits	90
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

MKL1_MOUSE
NC score	0.045492 (rank : 230)	θ value	2.36792 (rank : 209)
Query Neighborhood Hits	275	Target Neighborhood Hits	667	Shared Neighborhood Hits	55
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

SRRM2_HUMAN
NC score	0.044738 (rank : 231)	θ value	4.03905 (rank : 231)
Query Neighborhood Hits	275	Target Neighborhood Hits	1296	Shared Neighborhood Hits	80
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

RGS3_MOUSE
NC score	0.044587 (rank : 232)	θ value	0.62314 (rank : 161)
Query Neighborhood Hits	275	Target Neighborhood Hits	1621	Shared Neighborhood Hits	98
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

MDC1_HUMAN
NC score	0.043639 (rank : 233)	θ value	4.03905 (rank : 226)
Query Neighborhood Hits	275	Target Neighborhood Hits	1446	Shared Neighborhood Hits	81
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

OGFR_HUMAN
NC score	0.043518 (rank : 234)	θ value	0.813845 (rank : 167)
Query Neighborhood Hits	275	Target Neighborhood Hits	1582	Shared Neighborhood Hits	92
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

BSN_MOUSE
NC score	0.043100 (rank : 235)	θ value	4.03905 (rank : 222)
Query Neighborhood Hits	275	Target Neighborhood Hits	2057	Shared Neighborhood Hits	106
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

FARP2_HUMAN
NC score	0.042365 (rank : 236)	θ value	0.62314 (rank : 159)
Query Neighborhood Hits	275	Target Neighborhood Hits	240	Shared Neighborhood Hits	46
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

I20L2_HUMAN
NC score	0.041857 (rank : 237)	θ value	0.813845 (rank : 165)
Query Neighborhood Hits	275	Target Neighborhood Hits	42	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H9L3, Q64KA2	Gene names	ISG20L2
Domain Architecture
Description	Interferon-stimulated 20 kDa exonuclease-like 2 (EC 3.1.-.-).

CASC3_HUMAN
NC score	0.041141 (rank : 238)	θ value	0.125558 (rank : 130)
Query Neighborhood Hits	275	Target Neighborhood Hits	204	Shared Neighborhood Hits	21
SwissProt Accessions	O15234	Gene names	CASC3, MLN51
Domain Architecture	No domain graphic available
Description	Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node protein 51) (Protein MLN 51) (Protein barentsz) (Btz).

PCLO_HUMAN
NC score	0.040399 (rank : 239)	θ value	0.813845 (rank : 168)
Query Neighborhood Hits	275	Target Neighborhood Hits	2046	Shared Neighborhood Hits	105
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

HSF1_HUMAN
NC score	0.040031 (rank : 240)	θ value	1.06291 (rank : 175)
Query Neighborhood Hits	275	Target Neighborhood Hits	163	Shared Neighborhood Hits	14
SwissProt Accessions	Q00613	Gene names	HSF1, HSTF1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

SRRM2_MOUSE
NC score	0.038748 (rank : 241)	θ value	1.81305 (rank : 195)
Query Neighborhood Hits	275	Target Neighborhood Hits	1470	Shared Neighborhood Hits	89
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

FARP2_MOUSE
NC score	0.038470 (rank : 242)	θ value	1.06291 (rank : 173)
Query Neighborhood Hits	275	Target Neighborhood Hits	209	Shared Neighborhood Hits	41
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

NCOA6_HUMAN
NC score	0.038264 (rank : 243)	θ value	8.99809 (rank : 268)
Query Neighborhood Hits	275	Target Neighborhood Hits	1202	Shared Neighborhood Hits	78
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

TULP4_HUMAN
NC score	0.037312 (rank : 244)	θ value	0.62314 (rank : 163)
Query Neighborhood Hits	275	Target Neighborhood Hits	426	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NRJ4, Q9HD22, Q9P2F0	Gene names	TULP4, KIAA1397, TUSP
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

PO121_HUMAN
NC score	0.036814 (rank : 245)	θ value	0.365318 (rank : 153)
Query Neighborhood Hits	275	Target Neighborhood Hits	344	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y2N3, O75115, Q9Y4S7	Gene names	POM121, KIAA0618, NUP121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa) (P145).

BAT3_MOUSE
NC score	0.036554 (rank : 246)	θ value	1.81305 (rank : 187)
Query Neighborhood Hits	275	Target Neighborhood Hits	518	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

TARA_HUMAN
NC score	0.035526 (rank : 247)	θ value	0.279714 (rank : 146)
Query Neighborhood Hits	275	Target Neighborhood Hits	1626	Shared Neighborhood Hits	89
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

RTP3_MOUSE
NC score	0.035093 (rank : 248)	θ value	2.36792 (rank : 211)
Query Neighborhood Hits	275	Target Neighborhood Hits	374	Shared Neighborhood Hits	36
SwissProt Accessions	Q5QGU6, Q8VDC2	Gene names	Rtp3, Tmem7
Domain Architecture	No domain graphic available
Description	Receptor-transporting protein 3 (Transmembrane protein 7).

MTMR5_HUMAN
NC score	0.034580 (rank : 249)	θ value	6.88961 (rank : 255)
Query Neighborhood Hits	275	Target Neighborhood Hits	141	Shared Neighborhood Hits	31
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

CASC3_MOUSE
NC score	0.034180 (rank : 250)	θ value	2.36792 (rank : 200)
Query Neighborhood Hits	275	Target Neighborhood Hits	333	Shared Neighborhood Hits	27
SwissProt Accessions	Q8K3W3, Q8K219, Q99NF0	Gene names	Casc3, Mln51
Domain Architecture	No domain graphic available
Description	Protein CASC3 (Cancer susceptibility candidate gene 3 protein homolog) (Metastatic lymph node protein 51 homolog) (Protein MLN 51 homolog) (Protein barentsz) (Btz).

ABL1_HUMAN
NC score	0.033825 (rank : 251)	θ value	8.99809 (rank : 262)
Query Neighborhood Hits	275	Target Neighborhood Hits	1220	Shared Neighborhood Hits	70
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

K1543_HUMAN
NC score	0.033344 (rank : 252)	θ value	5.27518 (rank : 237)
Query Neighborhood Hits	275	Target Neighborhood Hits	435	Shared Neighborhood Hits	41
SwissProt Accessions	Q9P1Y5, Q8NDF1	Gene names	KIAA1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

CA036_MOUSE
NC score	0.032989 (rank : 253)	θ value	0.62314 (rank : 157)
Query Neighborhood Hits	275	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BRE0, Q9CRS3, Q9JMF2	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf36 homolog.

BAT3_HUMAN
NC score	0.031587 (rank : 254)	θ value	1.38821 (rank : 178)
Query Neighborhood Hits	275	Target Neighborhood Hits	490	Shared Neighborhood Hits	44
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

PCLO_MOUSE
NC score	0.031382 (rank : 255)	θ value	6.88961 (rank : 256)
Query Neighborhood Hits	275	Target Neighborhood Hits	2275	Shared Neighborhood Hits	99
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

CK024_HUMAN
NC score	0.031207 (rank : 256)	θ value	5.27518 (rank : 234)
Query Neighborhood Hits	275	Target Neighborhood Hits	408	Shared Neighborhood Hits	43
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

SON_MOUSE
NC score	0.030678 (rank : 257)	θ value	3.0926 (rank : 219)
Query Neighborhood Hits	275	Target Neighborhood Hits	957	Shared Neighborhood Hits	66
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

SNAG_MOUSE
NC score	0.030588 (rank : 258)	θ value	1.81305 (rank : 194)
Query Neighborhood Hits	275	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CWZ7, Q3TPT4	Gene names	Napg, Snapg
Domain Architecture	No domain graphic available
Description	Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide- sensitive factor attachment protein, gamma).

BSN_HUMAN
NC score	0.030500 (rank : 259)	θ value	8.99809 (rank : 264)
Query Neighborhood Hits	275	Target Neighborhood Hits	1537	Shared Neighborhood Hits	91
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

FA47A_HUMAN
NC score	0.030411 (rank : 260)	θ value	0.813845 (rank : 164)
Query Neighborhood Hits	275	Target Neighborhood Hits	451	Shared Neighborhood Hits	39
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

K1802_HUMAN
NC score	0.029864 (rank : 261)	θ value	0.0563607 (rank : 123)
Query Neighborhood Hits	275	Target Neighborhood Hits	1378	Shared Neighborhood Hits	77
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

JIP2_HUMAN
NC score	0.029384 (rank : 262)	θ value	2.36792 (rank : 208)
Query Neighborhood Hits	275	Target Neighborhood Hits	288	Shared Neighborhood Hits	25
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

PKDRE_MOUSE
NC score	0.029246 (rank : 263)	θ value	0.125558 (rank : 135)
Query Neighborhood Hits	275	Target Neighborhood Hits	76	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

AP180_MOUSE
NC score	0.029211 (rank : 264)	θ value	2.36792 (rank : 199)
Query Neighborhood Hits	275	Target Neighborhood Hits	194	Shared Neighborhood Hits	33
SwissProt Accessions	Q61548, Q61547	Gene names	Snap91
Domain Architecture
Description	Clathrin coat assembly protein AP180 (Clathrin coat-associated protein AP180) (91 kDa synaptosomal-associated protein) (Phosphoprotein F1- 20).

BMX_HUMAN
NC score	0.028946 (rank : 265)	θ value	6.88961 (rank : 243)
Query Neighborhood Hits	275	Target Neighborhood Hits	942	Shared Neighborhood Hits	53
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

SAPS1_HUMAN
NC score	0.028915 (rank : 266)	θ value	0.813845 (rank : 169)
Query Neighborhood Hits	275	Target Neighborhood Hits	704	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

SNAG_HUMAN
NC score	0.027140 (rank : 267)	θ value	3.0926 (rank : 218)
Query Neighborhood Hits	275	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	Q99747, Q9BUV1	Gene names	NAPG, SNAPG
Domain Architecture	No domain graphic available
Description	Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide- sensitive factor attachment protein, gamma).

AP180_HUMAN
NC score	0.026921 (rank : 268)	θ value	2.36792 (rank : 198)
Query Neighborhood Hits	275	Target Neighborhood Hits	183	Shared Neighborhood Hits	34
SwissProt Accessions	O60641, Q5JX13, Q68DL9, Q6P9D3, Q9NTY7	Gene names	SNAP91, KIAA0656
Domain Architecture
Description	Clathrin coat assembly protein AP180 (Clathrin coat-associated protein AP180) (91 kDa synaptosomal-associated protein).

SSBP4_HUMAN
NC score	0.026303 (rank : 269)	θ value	8.99809 (rank : 272)
Query Neighborhood Hits	275	Target Neighborhood Hits	753	Shared Neighborhood Hits	53
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

FMN2_HUMAN
NC score	0.026292 (rank : 270)	θ value	5.27518 (rank : 236)
Query Neighborhood Hits	275	Target Neighborhood Hits	484	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

CECR2_HUMAN
NC score	0.025437 (rank : 271)	θ value	6.88961 (rank : 245)
Query Neighborhood Hits	275	Target Neighborhood Hits	543	Shared Neighborhood Hits	41
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

ATX7_HUMAN
NC score	0.024923 (rank : 272)	θ value	0.62314 (rank : 156)
Query Neighborhood Hits	275	Target Neighborhood Hits	351	Shared Neighborhood Hits	29
SwissProt Accessions	O15265, O75328, O75329, Q9Y6P8	Gene names	ATXN7, SCA7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein).

PKDRE_HUMAN
NC score	0.024195 (rank : 273)	θ value	4.03905 (rank : 228)
Query Neighborhood Hits	275	Target Neighborhood Hits	64	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

ARI1B_HUMAN
NC score	0.023836 (rank : 274)	θ value	3.0926 (rank : 213)
Query Neighborhood Hits	275	Target Neighborhood Hits	567	Shared Neighborhood Hits	45
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

CA036_HUMAN
NC score	0.022949 (rank : 275)	θ value	5.27518 (rank : 233)
Query Neighborhood Hits	275	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z3Z2	Gene names	C1orf36
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf36.

PLCG1_MOUSE
NC score	0.022538 (rank : 276)	θ value	8.99809 (rank : 271)
Query Neighborhood Hits	275	Target Neighborhood Hits	314	Shared Neighborhood Hits	26
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

GRB7_HUMAN
NC score	0.022365 (rank : 277)	θ value	1.81305 (rank : 191)
Query Neighborhood Hits	275	Target Neighborhood Hits	156	Shared Neighborhood Hits	18
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

PLCG1_HUMAN
NC score	0.021988 (rank : 278)	θ value	8.99809 (rank : 270)
Query Neighborhood Hits	275	Target Neighborhood Hits	293	Shared Neighborhood Hits	27
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

FMN2_MOUSE
NC score	0.021305 (rank : 279)	θ value	4.03905 (rank : 224)
Query Neighborhood Hits	275	Target Neighborhood Hits	349	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JL04	Gene names	Fmn2
Domain Architecture
Description	Formin-2.

TXLNB_HUMAN
NC score	0.020883 (rank : 280)	θ value	0.0736092 (rank : 126)
Query Neighborhood Hits	275	Target Neighborhood Hits	912	Shared Neighborhood Hits	40
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

DEND_MOUSE
NC score	0.020135 (rank : 281)	θ value	1.81305 (rank : 189)
Query Neighborhood Hits	275	Target Neighborhood Hits	75	Shared Neighborhood Hits	10
SwissProt Accessions	Q80TS7	Gene names	Ddn, Kiaa0749
Domain Architecture	No domain graphic available
Description	Dendrin.

TAB3_MOUSE
NC score	0.019828 (rank : 282)	θ value	5.27518 (rank : 240)
Query Neighborhood Hits	275	Target Neighborhood Hits	273	Shared Neighborhood Hits	22
SwissProt Accessions	Q571K4	Gene names	Map3k7ip3, Kiaa4135, Tab3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3).

SETX_HUMAN
NC score	0.019827 (rank : 283)	θ value	0.47712 (rank : 155)
Query Neighborhood Hits	275	Target Neighborhood Hits	368	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z333, O75120, Q3KQX4, Q68DW5, Q6AZD7, Q7Z3J6, Q8WX33, Q9H9D1, Q9NVP9	Gene names	SETX, ALS4, KIAA0625, SCAR1
Domain Architecture
Description	Probable helicase senataxin (EC 3.6.1.-) (SEN1 homolog).

MAP1A_HUMAN
NC score	0.019027 (rank : 284)	θ value	8.99809 (rank : 266)
Query Neighborhood Hits	275	Target Neighborhood Hits	1626	Shared Neighborhood Hits	69
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

NKRF_MOUSE
NC score	0.018989 (rank : 285)	θ value	1.38821 (rank : 183)
Query Neighborhood Hits	275	Target Neighborhood Hits	67	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BY02, Q8BJU5, Q9CRL2	Gene names	Nkrf, Nrf
Domain Architecture
Description	NF-kappa-B-repressing factor (NFKB-repressing factor) (Transcription factor NRF).

DCC_MOUSE
NC score	0.018608 (rank : 286)	θ value	1.81305 (rank : 188)
Query Neighborhood Hits	275	Target Neighborhood Hits	896	Shared Neighborhood Hits	61
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

BCLF1_HUMAN
NC score	0.018204 (rank : 287)	θ value	1.06291 (rank : 171)
Query Neighborhood Hits	275	Target Neighborhood Hits	298	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NYF8, Q14673, Q86WU6, Q86WY0	Gene names	BCLAF1, BTF, KIAA0164
Domain Architecture	No domain graphic available
Description	Bcl-2-associated transcription factor 1 (Btf).

IWS1_MOUSE
NC score	0.018174 (rank : 288)	θ value	1.81305 (rank : 192)
Query Neighborhood Hits	275	Target Neighborhood Hits	1258	Shared Neighborhood Hits	57
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

DLG5_HUMAN
NC score	0.017922 (rank : 289)	θ value	0.21417 (rank : 141)
Query Neighborhood Hits	275	Target Neighborhood Hits	1088	Shared Neighborhood Hits	42
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

MAST4_HUMAN
NC score	0.017616 (rank : 290)	θ value	0.0113563 (rank : 108)
Query Neighborhood Hits	275	Target Neighborhood Hits	1804	Shared Neighborhood Hits	103
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MILK2_HUMAN
NC score	0.017366 (rank : 291)	θ value	1.38821 (rank : 182)
Query Neighborhood Hits	275	Target Neighborhood Hits	457	Shared Neighborhood Hits	31
SwissProt Accessions	Q8IY33, Q7RTP4, Q7Z655, Q8TEQ4, Q9H5F9	Gene names
Domain Architecture
Description	MICAL-like protein 2.

CEL_HUMAN
NC score	0.016339 (rank : 292)	θ value	6.88961 (rank : 246)
Query Neighborhood Hits	275	Target Neighborhood Hits	896	Shared Neighborhood Hits	55
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

CN004_MOUSE
NC score	0.015923 (rank : 293)	θ value	6.88961 (rank : 249)
Query Neighborhood Hits	275	Target Neighborhood Hits	105	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K3X4, Q3USE5, Q8BUS1, Q8C011	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf4 homolog.

DTX1_HUMAN
NC score	0.015748 (rank : 294)	θ value	1.06291 (rank : 172)
Query Neighborhood Hits	275	Target Neighborhood Hits	80	Shared Neighborhood Hits	14
SwissProt Accessions	Q86Y01, O60630, Q9BS04	Gene names	DTX1
Domain Architecture
Description	Protein deltex-1 (Deltex-1) (Deltex1) (hDTX1).

POZP3_HUMAN
NC score	0.015661 (rank : 295)	θ value	5.27518 (rank : 239)
Query Neighborhood Hits	275	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PJE2, Q12903, Q9BWB4	Gene names	POMZP3
Domain Architecture	No domain graphic available
Description	POM121 and ZP3 fusion protein (POM-ZP3).

CN004_HUMAN
NC score	0.015506 (rank : 296)	θ value	6.88961 (rank : 248)
Query Neighborhood Hits	275	Target Neighborhood Hits	108	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H1B7, Q8NDQ2, Q96JG2, Q9H3I7	Gene names	C14orf4, KIAA1865
Domain Architecture	No domain graphic available
Description	Protein C14orf4.

PEX14_MOUSE
NC score	0.015408 (rank : 297)	θ value	6.88961 (rank : 257)
Query Neighborhood Hits	275	Target Neighborhood Hits	62	Shared Neighborhood Hits	6
SwissProt Accessions	Q9R0A0	Gene names	Pex14
Domain Architecture
Description	Peroxisomal membrane protein PEX14 (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) (PTS1 receptor docking protein).

MAP1B_HUMAN
NC score	0.014925 (rank : 298)	θ value	3.0926 (rank : 217)
Query Neighborhood Hits	275	Target Neighborhood Hits	903	Shared Neighborhood Hits	40
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

MK15_HUMAN
NC score	0.014841 (rank : 299)	θ value	4.03905 (rank : 227)
Query Neighborhood Hits	275	Target Neighborhood Hits	1038	Shared Neighborhood Hits	58
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

IRF3_HUMAN
NC score	0.014500 (rank : 300)	θ value	2.36792 (rank : 207)
Query Neighborhood Hits	275	Target Neighborhood Hits	129	Shared Neighborhood Hits	10
SwissProt Accessions	Q14653	Gene names	IRF3
Domain Architecture
Description	Interferon regulatory factor 3 (IRF-3).

G7C_HUMAN
NC score	0.014474 (rank : 301)	θ value	2.36792 (rank : 204)
Query Neighborhood Hits	275	Target Neighborhood Hits	21	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y334, Q5SSR5, Q96QC8, Q9UMP9	Gene names	C6orf27, G7C, NG37
Domain Architecture	No domain graphic available
Description	Protein G7c precursor.

TNR8_HUMAN
NC score	0.014316 (rank : 302)	θ value	1.38821 (rank : 186)
Query Neighborhood Hits	275	Target Neighborhood Hits	198	Shared Neighborhood Hits	8
SwissProt Accessions	P28908	Gene names	TNFRSF8, CD30
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 8 precursor (CD30L receptor) (Lymphocyte activation antigen CD30) (KI-1 antigen).

PKHF1_MOUSE
NC score	0.014206 (rank : 303)	θ value	6.88961 (rank : 258)
Query Neighborhood Hits	275	Target Neighborhood Hits	80	Shared Neighborhood Hits	9
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

NEK1_MOUSE
NC score	0.013174 (rank : 304)	θ value	0.21417 (rank : 145)
Query Neighborhood Hits	275	Target Neighborhood Hits	1311	Shared Neighborhood Hits	44
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

M3K14_HUMAN
NC score	0.012942 (rank : 305)	θ value	0.813845 (rank : 166)
Query Neighborhood Hits	275	Target Neighborhood Hits	887	Shared Neighborhood Hits	45
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

CNOT4_MOUSE
NC score	0.012618 (rank : 306)	θ value	3.0926 (rank : 214)
Query Neighborhood Hits	275	Target Neighborhood Hits	277	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BT14, Q8CCR4, Q9CV74, Q9Z1D0	Gene names	Cnot4, Not4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

LR37A_HUMAN
NC score	0.012305 (rank : 307)	θ value	8.99809 (rank : 265)
Query Neighborhood Hits	275	Target Neighborhood Hits	720	Shared Neighborhood Hits	47
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

JIP1_HUMAN
NC score	0.011830 (rank : 308)	θ value	6.88961 (rank : 254)
Query Neighborhood Hits	275	Target Neighborhood Hits	271	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

CDT1_HUMAN
NC score	0.011583 (rank : 309)	θ value	6.88961 (rank : 244)
Query Neighborhood Hits	275	Target Neighborhood Hits	92	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H211, Q86XX9, Q96CJ5, Q96GK5, Q96H67, Q96HE6, Q9BWM0	Gene names	CDT1
Domain Architecture	No domain graphic available
Description	DNA replication factor Cdt1 (Double parked homolog) (DUP).

YETS2_MOUSE
NC score	0.011322 (rank : 310)	θ value	6.88961 (rank : 260)
Query Neighborhood Hits	275	Target Neighborhood Hits	278	Shared Neighborhood Hits	26
SwissProt Accessions	Q3TUF7, Q6PGF8, Q80TI2, Q8CG86	Gene names	Yeats2, Kiaa1197
Domain Architecture	No domain graphic available
Description	YEATS domain-containing protein 2.

CK035_HUMAN
NC score	0.011218 (rank : 311)	θ value	6.88961 (rank : 247)
Query Neighborhood Hits	275	Target Neighborhood Hits	149	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IXW0	Gene names	C11orf35
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf35.

STK10_MOUSE
NC score	0.011118 (rank : 312)	θ value	1.38821 (rank : 185)
Query Neighborhood Hits	275	Target Neighborhood Hits	2132	Shared Neighborhood Hits	69
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

UBQL4_HUMAN
NC score	0.010894 (rank : 313)	θ value	1.81305 (rank : 196)
Query Neighborhood Hits	275	Target Neighborhood Hits	117	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NRR5, Q9BR98, Q9UHX4	Gene names	UBQLN4, C1orf6, UBIN
Domain Architecture
Description	Ubiquilin-4 (Ataxin-1 ubiquitin-like-interacting protein A1U).

PKD1_HUMAN
NC score	0.009968 (rank : 314)	θ value	1.38821 (rank : 184)
Query Neighborhood Hits	275	Target Neighborhood Hits	387	Shared Neighborhood Hits	9
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

COHA1_MOUSE
NC score	0.009740 (rank : 315)	θ value	6.88961 (rank : 250)
Query Neighborhood Hits	275	Target Neighborhood Hits	414	Shared Neighborhood Hits	36
SwissProt Accessions	Q07563, Q99LK8	Gene names	Col17a1, Bp180, Bpag2
Domain Architecture
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

MEGF9_MOUSE
NC score	0.009685 (rank : 316)	θ value	8.99809 (rank : 267)
Query Neighborhood Hits	275	Target Neighborhood Hits	896	Shared Neighborhood Hits	58
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

NFAT5_HUMAN
NC score	0.008829 (rank : 317)	θ value	2.36792 (rank : 210)
Query Neighborhood Hits	275	Target Neighborhood Hits	217	Shared Neighborhood Hits	8
SwissProt Accessions	O94916, O95693, Q9UN18	Gene names	NFAT5, KIAA0827, TONEBP
Domain Architecture
Description	Nuclear factor of activated T-cells 5 (T-cell transcription factor NFAT5) (NF-AT5) (Tonicity-responsive enhancer-binding protein) (TonE- binding protein) (TonEBP).

DLG3_HUMAN
NC score	0.008616 (rank : 318)	θ value	1.38821 (rank : 180)
Query Neighborhood Hits	275	Target Neighborhood Hits	269	Shared Neighborhood Hits	12
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG3_MOUSE
NC score	0.008594 (rank : 319)	θ value	1.38821 (rank : 181)
Query Neighborhood Hits	275	Target Neighborhood Hits	274	Shared Neighborhood Hits	12
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

NIPA_HUMAN
NC score	0.008426 (rank : 320)	θ value	8.99809 (rank : 269)
Query Neighborhood Hits	275	Target Neighborhood Hits	37	Shared Neighborhood Hits	7
SwissProt Accessions	Q86WB0, Q75MF3, Q75MF4, Q8N330, Q96F75, Q9HA34, Q9NVX4, Q9P0R0	Gene names	ZC3HC1, NIPA
Domain Architecture	No domain graphic available
Description	Nuclear-interacting partner of ALK (Nuclear-interacting partner of anaplastic lymphoma kinase) (hNIPA) (Zinc finger C3HC-type protein 1).

GAK_HUMAN
NC score	0.007943 (rank : 321)	θ value	4.03905 (rank : 225)
Query Neighborhood Hits	275	Target Neighborhood Hits	1028	Shared Neighborhood Hits	47
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

LRSM1_HUMAN
NC score	0.007922 (rank : 322)	θ value	5.27518 (rank : 238)
Query Neighborhood Hits	275	Target Neighborhood Hits	1078	Shared Neighborhood Hits	35
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

KCNH2_MOUSE
NC score	0.007762 (rank : 323)	θ value	1.81305 (rank : 193)
Query Neighborhood Hits	275	Target Neighborhood Hits	165	Shared Neighborhood Hits	13
SwissProt Accessions	O35219, O35220, O35221, O35989	Gene names	Kcnh2, Erg, Merg1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (ERG1) (MERG) (Merg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1).

FOXN4_MOUSE
NC score	0.006362 (rank : 324)	θ value	1.06291 (rank : 174)
Query Neighborhood Hits	275	Target Neighborhood Hits	154	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K3Q3, Q920C0	Gene names	Foxn4
Domain Architecture
Description	Forkhead box protein N4.

ARNT_MOUSE
NC score	0.006070 (rank : 325)	θ value	5.27518 (rank : 232)
Query Neighborhood Hits	275	Target Neighborhood Hits	213	Shared Neighborhood Hits	16
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ZSWM3_MOUSE
NC score	0.005641 (rank : 326)	θ value	8.99809 (rank : 275)
Query Neighborhood Hits	275	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CFL8	Gene names	Zswim3
Domain Architecture
Description	Zinc finger SWIM domain-containing protein 3.

VTNC_MOUSE
NC score	0.005099 (rank : 327)	θ value	5.27518 (rank : 241)
Query Neighborhood Hits	275	Target Neighborhood Hits	74	Shared Neighborhood Hits	5
SwissProt Accessions	P29788, Q8VII4	Gene names	Vtn
Domain Architecture
Description	Vitronectin precursor (Serum-spreading factor) (S-protein).

ZFY19_MOUSE
NC score	0.005093 (rank : 328)	θ value	8.99809 (rank : 274)
Query Neighborhood Hits	275	Target Neighborhood Hits	143	Shared Neighborhood Hits	6
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

AZI1_HUMAN
NC score	0.004261 (rank : 329)	θ value	8.99809 (rank : 263)
Query Neighborhood Hits	275	Target Neighborhood Hits	1000	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

ELK4_HUMAN
NC score	0.003424 (rank : 330)	θ value	6.88961 (rank : 251)
Query Neighborhood Hits	275	Target Neighborhood Hits	184	Shared Neighborhood Hits	15
SwissProt Accessions	P28324, P28323	Gene names	ELK4, SAP1
Domain Architecture
Description	ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1).

ABCA5_MOUSE
NC score	0.003257 (rank : 331)	θ value	4.03905 (rank : 221)
Query Neighborhood Hits	275	Target Neighborhood Hits	137	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K448, Q3TE17, Q3UUB4, Q6P1Y0, Q6ZPG4, Q810C7, Q8BM46, Q8BXG7	Gene names	Abca5, Kiaa1888
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 5.

CSPG3_HUMAN
NC score	0.002360 (rank : 332)	θ value	3.0926 (rank : 215)
Query Neighborhood Hits	275	Target Neighborhood Hits	676	Shared Neighborhood Hits	30
SwissProt Accessions	O14594, Q9UPK6	Gene names	CSPG3, NCAN, NEUR
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

GAK3_HUMAN
NC score	0.002343 (rank : 333)	θ value	6.88961 (rank : 253)
Query Neighborhood Hits	275	Target Neighborhood Hits	182	Shared Neighborhood Hits	9
SwissProt Accessions	Q9YNA8	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19q12 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(C19) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

CK5P2_MOUSE
NC score	0.001909 (rank : 334)	θ value	5.27518 (rank : 235)
Query Neighborhood Hits	275	Target Neighborhood Hits	1151	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

ZN687_HUMAN
NC score	0.001759 (rank : 335)	θ value	3.0926 (rank : 220)
Query Neighborhood Hits	275	Target Neighborhood Hits	1244	Shared Neighborhood Hits	49
SwissProt Accessions	Q8N1G0, Q68DQ8, Q9H937, Q9P2A7	Gene names	ZNF687, KIAA1441
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

HXA10_HUMAN
NC score	0.000803 (rank : 336)	θ value	2.36792 (rank : 205)
Query Neighborhood Hits	275	Target Neighborhood Hits	334	Shared Neighborhood Hits	8
SwissProt Accessions	P31260, O43370, O43605, Q15949	Gene names	HOXA10, HOX1H
Domain Architecture
Description	Homeobox protein Hox-A10 (Hox-1H) (Hox-1.8) (PL).

TRI56_HUMAN
NC score	0.000651 (rank : 337)	θ value	8.99809 (rank : 273)
Query Neighborhood Hits	275	Target Neighborhood Hits	339	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BRZ2, Q86VT6, Q8N2H8, Q8NAC0, Q9H031	Gene names	TRIM56, RNF109
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 56 (RING finger protein 109).

HXB4_MOUSE
NC score	0.000494 (rank : 338)	θ value	2.36792 (rank : 206)
Query Neighborhood Hits	275	Target Neighborhood Hits	375	Shared Neighborhood Hits	15
SwissProt Accessions	P10284, Q3UZB4, Q4VBG0	Gene names	Hoxb4, Hox-2.6, Hoxb-4
Domain Architecture
Description	Homeobox protein Hox-B4 (Hox-2.6).

ZN406_HUMAN
NC score	-0.001553 (rank : 339)	θ value	0.0193708 (rank : 112)
Query Neighborhood Hits	275	Target Neighborhood Hits	794	Shared Neighborhood Hits	8
SwissProt Accessions	Q9P243, Q3MIM5, Q6PJ01, Q75PJ7, Q75PJ9, Q86X64	Gene names	ZNF406, KIAA1485
Domain Architecture	No domain graphic available
Description	Zinc finger protein 406 (Protein ZFAT).

SLIT1_MOUSE
NC score	-0.005067 (rank : 340)	θ value	6.88961 (rank : 259)
Query Neighborhood Hits	275	Target Neighborhood Hits	715	Shared Neighborhood Hits	7
SwissProt Accessions	Q80TR4, Q9WVB5	Gene names	Slit1, Kiaa0813
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1).

GFI1_HUMAN
NC score	-0.006810 (rank : 341)	θ value	3.0926 (rank : 216)
Query Neighborhood Hits	275	Target Neighborhood Hits	726	Shared Neighborhood Hits	7
SwissProt Accessions	Q99684, Q8N564	Gene names	GFI1, ZNF163
Domain Architecture	No domain graphic available
Description	Zinc finger protein Gfi-1 (Growth factor independence 1).

ZN202_HUMAN
NC score	-0.007367 (rank : 342)	θ value	6.88961 (rank : 261)
Query Neighborhood Hits	275	Target Neighborhood Hits	756	Shared Neighborhood Hits	10
SwissProt Accessions	O95125, Q4JG21, Q9H1B9, Q9NSM4	Gene names	ZNF202
Domain Architecture
Description	Zinc finger protein 202.