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Network neighborhood for query Sequence : PLEK2_HUMAN

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PLEK2_HUMAN
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PLEK2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	101	Target Neighborhood Hits	101	Shared Neighborhood Hits	101
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_MOUSE
θ value	0 (rank : 2)	NC score	0.996033 (rank : 2)
Query Neighborhood Hits	101	Target Neighborhood Hits	96	Shared Neighborhood Hits	95
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PLEK_HUMAN
θ value	1.45591e-66 (rank : 3)	NC score	0.896208 (rank : 4)
Query Neighborhood Hits	101	Target Neighborhood Hits	110	Shared Neighborhood Hits	72
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PLEK_MOUSE
θ value	2.74572e-65 (rank : 4)	NC score	0.898166 (rank : 3)
Query Neighborhood Hits	101	Target Neighborhood Hits	109	Shared Neighborhood Hits	72
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

PKHA1_MOUSE
θ value	8.97725e-08 (rank : 5)	NC score	0.501225 (rank : 5)
Query Neighborhood Hits	101	Target Neighborhood Hits	120	Shared Neighborhood Hits	68
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

SWP70_MOUSE
θ value	1.17247e-07 (rank : 6)	NC score	0.254698 (rank : 26)
Query Neighborhood Hits	101	Target Neighborhood Hits	1097	Shared Neighborhood Hits	72
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_HUMAN
θ value	1.53129e-07 (rank : 7)	NC score	0.262093 (rank : 25)
Query Neighborhood Hits	101	Target Neighborhood Hits	973	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

PKHA1_HUMAN
θ value	2.61198e-07 (rank : 8)	NC score	0.497453 (rank : 6)
Query Neighborhood Hits	101	Target Neighborhood Hits	127	Shared Neighborhood Hits	70
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_HUMAN
θ value	1.43324e-05 (rank : 9)	NC score	0.455347 (rank : 7)
Query Neighborhood Hits	101	Target Neighborhood Hits	119	Shared Neighborhood Hits	64
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

RHG25_MOUSE
θ value	1.87187e-05 (rank : 10)	NC score	0.265967 (rank : 24)
Query Neighborhood Hits	101	Target Neighborhood Hits	492	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_HUMAN
θ value	2.44474e-05 (rank : 11)	NC score	0.274289 (rank : 22)
Query Neighborhood Hits	101	Target Neighborhood Hits	550	Shared Neighborhood Hits	77
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

DAPP1_MOUSE
θ value	3.19293e-05 (rank : 12)	NC score	0.341735 (rank : 9)
Query Neighborhood Hits	101	Target Neighborhood Hits	225	Shared Neighborhood Hits	70
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_HUMAN
θ value	4.1701e-05 (rank : 13)	NC score	0.339111 (rank : 10)
Query Neighborhood Hits	101	Target Neighborhood Hits	227	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PKHA2_MOUSE
θ value	5.44631e-05 (rank : 14)	NC score	0.448200 (rank : 8)
Query Neighborhood Hits	101	Target Neighborhood Hits	116	Shared Neighborhood Hits	65
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

CYH4_HUMAN
θ value	9.29e-05 (rank : 15)	NC score	0.331024 (rank : 11)
Query Neighborhood Hits	101	Target Neighborhood Hits	135	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

CYH4_MOUSE
θ value	0.00020696 (rank : 16)	NC score	0.329141 (rank : 12)
Query Neighborhood Hits	101	Target Neighborhood Hits	134	Shared Neighborhood Hits	71
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

MYO10_HUMAN
θ value	0.00035302 (rank : 17)	NC score	0.111079 (rank : 65)
Query Neighborhood Hits	101	Target Neighborhood Hits	920	Shared Neighborhood Hits	76
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

CYH3_MOUSE
θ value	0.000602161 (rank : 18)	NC score	0.321727 (rank : 13)
Query Neighborhood Hits	101	Target Neighborhood Hits	148	Shared Neighborhood Hits	74
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

RASA1_HUMAN
θ value	0.00134147 (rank : 19)	NC score	0.204773 (rank : 35)
Query Neighborhood Hits	101	Target Neighborhood Hits	258	Shared Neighborhood Hits	51
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

AKT3_HUMAN
θ value	0.00175202 (rank : 20)	NC score	0.058325 (rank : 119)
Query Neighborhood Hits	101	Target Neighborhood Hits	872	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
θ value	0.00175202 (rank : 21)	NC score	0.058314 (rank : 120)
Query Neighborhood Hits	101	Target Neighborhood Hits	872	Shared Neighborhood Hits	37
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

GNRP_HUMAN
θ value	0.00175202 (rank : 22)	NC score	0.176206 (rank : 40)
Query Neighborhood Hits	101	Target Neighborhood Hits	239	Shared Neighborhood Hits	49
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

CYH2_HUMAN
θ value	0.00228821 (rank : 23)	NC score	0.301622 (rank : 16)
Query Neighborhood Hits	101	Target Neighborhood Hits	175	Shared Neighborhood Hits	70
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	0.00228821 (rank : 24)	NC score	0.301643 (rank : 15)
Query Neighborhood Hits	101	Target Neighborhood Hits	171	Shared Neighborhood Hits	70
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH1_HUMAN
θ value	0.00509761 (rank : 25)	NC score	0.306265 (rank : 14)
Query Neighborhood Hits	101	Target Neighborhood Hits	184	Shared Neighborhood Hits	74
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
θ value	0.00509761 (rank : 26)	NC score	0.300891 (rank : 17)
Query Neighborhood Hits	101	Target Neighborhood Hits	176	Shared Neighborhood Hits	70
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

OSB11_HUMAN
θ value	0.00509761 (rank : 27)	NC score	0.215772 (rank : 31)
Query Neighborhood Hits	101	Target Neighborhood Hits	60	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BXB4	Gene names	OSBPL11, ORP11, OSBP12
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

OSB11_MOUSE
θ value	0.00509761 (rank : 28)	NC score	0.215710 (rank : 32)
Query Neighborhood Hits	101	Target Neighborhood Hits	71	Shared Neighborhood Hits	30
SwissProt Accessions	Q8CI95	Gene names	Osbpl11
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

3BP2_HUMAN
θ value	0.00665767 (rank : 29)	NC score	0.270976 (rank : 23)
Query Neighborhood Hits	101	Target Neighborhood Hits	296	Shared Neighborhood Hits	33
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

OSBL9_HUMAN
θ value	0.00665767 (rank : 30)	NC score	0.236187 (rank : 28)
Query Neighborhood Hits	101	Target Neighborhood Hits	138	Shared Neighborhood Hits	49
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

3BP2_MOUSE
θ value	0.00869519 (rank : 31)	NC score	0.278018 (rank : 21)
Query Neighborhood Hits	101	Target Neighborhood Hits	142	Shared Neighborhood Hits	30
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

AKT2_HUMAN
θ value	0.00869519 (rank : 32)	NC score	0.062152 (rank : 114)
Query Neighborhood Hits	101	Target Neighborhood Hits	878	Shared Neighborhood Hits	43
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT2_MOUSE
θ value	0.00869519 (rank : 33)	NC score	0.062564 (rank : 113)
Query Neighborhood Hits	101	Target Neighborhood Hits	875	Shared Neighborhood Hits	42
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

CENB5_HUMAN
θ value	0.0148317 (rank : 34)	NC score	0.125266 (rank : 55)
Query Neighborhood Hits	101	Target Neighborhood Hits	395	Shared Neighborhood Hits	45
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CYH3_HUMAN
θ value	0.0148317 (rank : 35)	NC score	0.295518 (rank : 18)
Query Neighborhood Hits	101	Target Neighborhood Hits	137	Shared Neighborhood Hits	67
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

DVL3_HUMAN
θ value	0.0148317 (rank : 36)	NC score	0.089247 (rank : 83)
Query Neighborhood Hits	101	Target Neighborhood Hits	194	Shared Neighborhood Hits	11
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_MOUSE
θ value	0.0148317 (rank : 37)	NC score	0.089279 (rank : 82)
Query Neighborhood Hits	101	Target Neighborhood Hits	198	Shared Neighborhood Hits	14
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

CENA2_HUMAN
θ value	0.0193708 (rank : 38)	NC score	0.161427 (rank : 43)
Query Neighborhood Hits	101	Target Neighborhood Hits	83	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

C43BP_MOUSE
θ value	0.0252991 (rank : 39)	NC score	0.240652 (rank : 27)
Query Neighborhood Hits	101	Target Neighborhood Hits	91	Shared Neighborhood Hits	51
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

CENA2_MOUSE
θ value	0.0252991 (rank : 40)	NC score	0.119742 (rank : 59)
Query Neighborhood Hits	101	Target Neighborhood Hits	68	Shared Neighborhood Hits	33
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

GNRP_MOUSE
θ value	0.0330416 (rank : 41)	NC score	0.162120 (rank : 42)
Query Neighborhood Hits	101	Target Neighborhood Hits	191	Shared Neighborhood Hits	48
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

AKT1_HUMAN
θ value	0.0431538 (rank : 42)	NC score	0.056936 (rank : 123)
Query Neighborhood Hits	101	Target Neighborhood Hits	885	Shared Neighborhood Hits	48
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

AKT1_MOUSE
θ value	0.0431538 (rank : 43)	NC score	0.056958 (rank : 122)
Query Neighborhood Hits	101	Target Neighborhood Hits	878	Shared Neighborhood Hits	48
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

BMX_MOUSE
θ value	0.0431538 (rank : 44)	NC score	0.038608 (rank : 136)
Query Neighborhood Hits	101	Target Neighborhood Hits	912	Shared Neighborhood Hits	42
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

RPGF4_MOUSE
θ value	0.0431538 (rank : 45)	NC score	0.069084 (rank : 108)
Query Neighborhood Hits	101	Target Neighborhood Hits	80	Shared Neighborhood Hits	10
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

FGD6_HUMAN
θ value	0.0563607 (rank : 46)	NC score	0.075021 (rank : 98)
Query Neighborhood Hits	101	Target Neighborhood Hits	237	Shared Neighborhood Hits	43
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

OSBP1_HUMAN
θ value	0.0563607 (rank : 47)	NC score	0.154409 (rank : 45)
Query Neighborhood Hits	101	Target Neighborhood Hits	180	Shared Neighborhood Hits	56
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

PHLB1_MOUSE
θ value	0.0736092 (rank : 48)	NC score	0.149077 (rank : 47)
Query Neighborhood Hits	101	Target Neighborhood Hits	678	Shared Neighborhood Hits	43
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PKHA6_HUMAN
θ value	0.0736092 (rank : 49)	NC score	0.281564 (rank : 19)
Query Neighborhood Hits	101	Target Neighborhood Hits	556	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

C43BP_HUMAN
θ value	0.0961366 (rank : 50)	NC score	0.224027 (rank : 29)
Query Neighborhood Hits	101	Target Neighborhood Hits	87	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

OSB10_HUMAN
θ value	0.0961366 (rank : 51)	NC score	0.177075 (rank : 39)
Query Neighborhood Hits	101	Target Neighborhood Hits	55	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BXB5, Q9BTU5	Gene names	OSBPL10, ORP10, OSBP9
Domain Architecture
Description	Oxysterol-binding protein-related protein 10 (OSBP-related protein 10) (ORP-10).

RHG12_HUMAN
θ value	0.0961366 (rank : 52)	NC score	0.074351 (rank : 100)
Query Neighborhood Hits	101	Target Neighborhood Hits	190	Shared Neighborhood Hits	12
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

BMX_HUMAN
θ value	0.163984 (rank : 53)	NC score	0.038954 (rank : 135)
Query Neighborhood Hits	101	Target Neighborhood Hits	942	Shared Neighborhood Hits	44
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

CENB2_HUMAN
θ value	0.163984 (rank : 54)	NC score	0.146695 (rank : 49)
Query Neighborhood Hits	101	Target Neighborhood Hits	425	Shared Neighborhood Hits	48
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

PKHA6_MOUSE
θ value	0.163984 (rank : 55)	NC score	0.279861 (rank : 20)
Query Neighborhood Hits	101	Target Neighborhood Hits	591	Shared Neighborhood Hits	80
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

SPTN4_HUMAN
θ value	0.163984 (rank : 56)	NC score	0.035008 (rank : 137)
Query Neighborhood Hits	101	Target Neighborhood Hits	570	Shared Neighborhood Hits	23
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

PHLB2_MOUSE
θ value	0.21417 (rank : 57)	NC score	0.126423 (rank : 54)
Query Neighborhood Hits	101	Target Neighborhood Hits	1016	Shared Neighborhood Hits	50
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PREX1_HUMAN
θ value	0.21417 (rank : 58)	NC score	0.070072 (rank : 107)
Query Neighborhood Hits	101	Target Neighborhood Hits	177	Shared Neighborhood Hits	21
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

CENA1_HUMAN
θ value	0.279714 (rank : 59)	NC score	0.133999 (rank : 52)
Query Neighborhood Hits	101	Target Neighborhood Hits	87	Shared Neighborhood Hits	35
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

GAB2_MOUSE
θ value	0.279714 (rank : 60)	NC score	0.206430 (rank : 34)
Query Neighborhood Hits	101	Target Neighborhood Hits	220	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

GAB1_HUMAN
θ value	0.365318 (rank : 61)	NC score	0.198614 (rank : 36)
Query Neighborhood Hits	101	Target Neighborhood Hits	279	Shared Neighborhood Hits	44
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

RASA3_HUMAN
θ value	0.365318 (rank : 62)	NC score	0.116143 (rank : 61)
Query Neighborhood Hits	101	Target Neighborhood Hits	166	Shared Neighborhood Hits	40
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

RHG12_MOUSE
θ value	0.365318 (rank : 63)	NC score	0.071326 (rank : 103)
Query Neighborhood Hits	101	Target Neighborhood Hits	204	Shared Neighborhood Hits	13
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

PKHA3_HUMAN
θ value	0.47712 (rank : 64)	NC score	0.218846 (rank : 30)
Query Neighborhood Hits	101	Target Neighborhood Hits	66	Shared Neighborhood Hits	43
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PKHA5_HUMAN
θ value	0.47712 (rank : 65)	NC score	0.192778 (rank : 37)
Query Neighborhood Hits	101	Target Neighborhood Hits	455	Shared Neighborhood Hits	73
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

RPGF4_HUMAN
θ value	0.47712 (rank : 66)	NC score	0.060810 (rank : 116)
Query Neighborhood Hits	101	Target Neighborhood Hits	88	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

DOC10_HUMAN
θ value	0.62314 (rank : 67)	NC score	0.075688 (rank : 97)
Query Neighborhood Hits	101	Target Neighborhood Hits	88	Shared Neighborhood Hits	22
SwissProt Accessions	Q96BY6, O75178, Q9NW06, Q9NXI8	Gene names	DOCK10, KIAA0694
Domain Architecture
Description	Dedicator of cytokinesis protein 10 (Protein zizimin 3).

PHLB2_HUMAN
θ value	0.62314 (rank : 68)	NC score	0.122368 (rank : 58)
Query Neighborhood Hits	101	Target Neighborhood Hits	964	Shared Neighborhood Hits	48
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

CENB1_HUMAN
θ value	0.813845 (rank : 69)	NC score	0.112232 (rank : 63)
Query Neighborhood Hits	101	Target Neighborhood Hits	383	Shared Neighborhood Hits	46
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

MTMRD_HUMAN
θ value	0.813845 (rank : 70)	NC score	0.137527 (rank : 51)
Query Neighborhood Hits	101	Target Neighborhood Hits	135	Shared Neighborhood Hits	56
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

OSBP2_HUMAN
θ value	0.813845 (rank : 71)	NC score	0.124356 (rank : 57)
Query Neighborhood Hits	101	Target Neighborhood Hits	154	Shared Neighborhood Hits	48
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

PKHA3_MOUSE
θ value	0.813845 (rank : 72)	NC score	0.215388 (rank : 33)
Query Neighborhood Hits	101	Target Neighborhood Hits	67	Shared Neighborhood Hits	44
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

ANLN_HUMAN
θ value	1.06291 (rank : 73)	NC score	0.099497 (rank : 73)
Query Neighborhood Hits	101	Target Neighborhood Hits	222	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NQW6, Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0	Gene names	ANLN
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

RASA3_MOUSE
θ value	1.06291 (rank : 74)	NC score	0.108088 (rank : 67)
Query Neighborhood Hits	101	Target Neighborhood Hits	144	Shared Neighborhood Hits	37
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

RGS6_HUMAN
θ value	1.06291 (rank : 75)	NC score	0.043894 (rank : 128)
Query Neighborhood Hits	101	Target Neighborhood Hits	80	Shared Neighborhood Hits	8
SwissProt Accessions	P49758, O75576, O75577, Q8TE13, Q8TE14, Q8TE15, Q8TE16, Q8TE17, Q8TE18, Q8TE19, Q8TE20, Q8TE21, Q8TE22, Q9Y245, Q9Y647	Gene names	RGS6
Domain Architecture
Description	Regulator of G-protein signaling 6 (RGS6) (S914).

RGS6_MOUSE
θ value	1.06291 (rank : 76)	NC score	0.042230 (rank : 131)
Query Neighborhood Hits	101	Target Neighborhood Hits	71	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Z2H2, Q8BGI8	Gene names	Rgs6
Domain Architecture	No domain graphic available
Description	Regulator of G-protein signaling 6 (RGS6).

ITK_HUMAN
θ value	1.38821 (rank : 77)	NC score	0.025652 (rank : 139)
Query Neighborhood Hits	101	Target Neighborhood Hits	1016	Shared Neighborhood Hits	32
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

MTMR5_HUMAN
θ value	1.38821 (rank : 78)	NC score	0.130933 (rank : 53)
Query Neighborhood Hits	101	Target Neighborhood Hits	141	Shared Neighborhood Hits	47
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

PHLB1_HUMAN
θ value	1.38821 (rank : 79)	NC score	0.117130 (rank : 60)
Query Neighborhood Hits	101	Target Neighborhood Hits	1038	Shared Neighborhood Hits	42
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PKHB1_MOUSE
θ value	1.38821 (rank : 80)	NC score	0.104119 (rank : 71)
Query Neighborhood Hits	101	Target Neighborhood Hits	47	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

ANLN_MOUSE
θ value	1.81305 (rank : 81)	NC score	0.088079 (rank : 88)
Query Neighborhood Hits	101	Target Neighborhood Hits	297	Shared Neighborhood Hits	21
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

DGKH_HUMAN
θ value	2.36792 (rank : 82)	NC score	0.088500 (rank : 85)
Query Neighborhood Hits	101	Target Neighborhood Hits	255	Shared Neighborhood Hits	48
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

DOCK9_HUMAN
θ value	2.36792 (rank : 83)	NC score	0.070741 (rank : 105)
Query Neighborhood Hits	101	Target Neighborhood Hits	82	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BZ29, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4	Gene names	DOCK9, KIAA1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

DOCK9_MOUSE
θ value	2.36792 (rank : 84)	NC score	0.070202 (rank : 106)
Query Neighborhood Hits	101	Target Neighborhood Hits	79	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BIK4, Q921Y6	Gene names	Dock9, D14Wsu89e, Kiaa1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

OSBP2_MOUSE
θ value	2.36792 (rank : 85)	NC score	0.109535 (rank : 66)
Query Neighborhood Hits	101	Target Neighborhood Hits	150	Shared Neighborhood Hits	42
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

IRS1_HUMAN
θ value	3.0926 (rank : 86)	NC score	0.043294 (rank : 129)
Query Neighborhood Hits	101	Target Neighborhood Hits	109	Shared Neighborhood Hits	15
SwissProt Accessions	P35568	Gene names	IRS1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

MRIP_HUMAN
θ value	3.0926 (rank : 87)	NC score	0.100883 (rank : 72)
Query Neighborhood Hits	101	Target Neighborhood Hits	578	Shared Neighborhood Hits	52
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

TIAM1_MOUSE
θ value	3.0926 (rank : 88)	NC score	0.046182 (rank : 127)
Query Neighborhood Hits	101	Target Neighborhood Hits	205	Shared Neighborhood Hits	17
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

GAB2_HUMAN
θ value	4.03905 (rank : 89)	NC score	0.188426 (rank : 38)
Query Neighborhood Hits	101	Target Neighborhood Hits	188	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

IRS1_MOUSE
θ value	4.03905 (rank : 90)	NC score	0.040102 (rank : 134)
Query Neighborhood Hits	101	Target Neighborhood Hits	112	Shared Neighborhood Hits	13
SwissProt Accessions	P35569	Gene names	Irs1, Irs-1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

TARA_HUMAN
θ value	4.03905 (rank : 91)	NC score	0.057652 (rank : 121)
Query Neighborhood Hits	101	Target Neighborhood Hits	1626	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TARA_MOUSE
θ value	4.03905 (rank : 92)	NC score	0.072035 (rank : 102)
Query Neighborhood Hits	101	Target Neighborhood Hits	1133	Shared Neighborhood Hits	48
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

MRIP_MOUSE
θ value	5.27518 (rank : 93)	NC score	0.097726 (rank : 77)
Query Neighborhood Hits	101	Target Neighborhood Hits	569	Shared Neighborhood Hits	54
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

PKHB1_HUMAN
θ value	5.27518 (rank : 94)	NC score	0.093411 (rank : 78)
Query Neighborhood Hits	101	Target Neighborhood Hits	46	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

PSD4_MOUSE
θ value	5.27518 (rank : 95)	NC score	0.124819 (rank : 56)
Query Neighborhood Hits	101	Target Neighborhood Hits	78	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

RGS9_HUMAN
θ value	5.27518 (rank : 96)	NC score	0.030138 (rank : 138)
Query Neighborhood Hits	101	Target Neighborhood Hits	64	Shared Neighborhood Hits	9
SwissProt Accessions	O75916, O75573, Q696R2, Q8TD64, Q8TD65, Q9HC32, Q9HC33	Gene names	RGS9
Domain Architecture
Description	Regulator of G-protein signaling 9 (RGS9).

DVL2_MOUSE
θ value	6.88961 (rank : 97)	NC score	0.041158 (rank : 133)
Query Neighborhood Hits	101	Target Neighborhood Hits	233	Shared Neighborhood Hits	7
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DGKD_HUMAN
θ value	8.99809 (rank : 98)	NC score	0.054740 (rank : 125)
Query Neighborhood Hits	101	Target Neighborhood Hits	231	Shared Neighborhood Hits	27
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

FGD5_HUMAN
θ value	8.99809 (rank : 99)	NC score	0.042253 (rank : 130)
Query Neighborhood Hits	101	Target Neighborhood Hits	235	Shared Neighborhood Hits	30
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

OPA1_MOUSE
θ value	8.99809 (rank : 100)	NC score	0.008312 (rank : 140)
Query Neighborhood Hits	101	Target Neighborhood Hits	79	Shared Neighborhood Hits	3
SwissProt Accessions	P58281, Q3ULA5, Q8BKU7, Q8BLL3, Q8BM08, Q8R3J7	Gene names	Opa1
Domain Architecture
Description	Dynamin-like 120 kDa protein, mitochondrial precursor (Optic atrophy protein 1 homolog) (Large GTP-binding protein) (LargeG) [Contains: Dynamin-like 120 kDa protein, form S1].

TIAM1_HUMAN
θ value	8.99809 (rank : 101)	NC score	0.042145 (rank : 132)
Query Neighborhood Hits	101	Target Neighborhood Hits	225	Shared Neighborhood Hits	17
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

BIG1_HUMAN
θ value	θ > 10 (rank : 102)	NC score	0.098093 (rank : 76)
Query Neighborhood Hits	101	Target Neighborhood Hits	76	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

BIG2_HUMAN
θ value	θ > 10 (rank : 103)	NC score	0.099170 (rank : 75)
Query Neighborhood Hits	101	Target Neighborhood Hits	66	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

CEND1_HUMAN
θ value	θ > 10 (rank : 104)	NC score	0.083405 (rank : 92)
Query Neighborhood Hits	101	Target Neighborhood Hits	284	Shared Neighborhood Hits	59
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CEND1_MOUSE
θ value	θ > 10 (rank : 105)	NC score	0.063220 (rank : 112)
Query Neighborhood Hits	101	Target Neighborhood Hits	260	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CEND2_HUMAN
θ value	θ > 10 (rank : 106)	NC score	0.086385 (rank : 89)
Query Neighborhood Hits	101	Target Neighborhood Hits	166	Shared Neighborhood Hits	55
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

CEND3_HUMAN
θ value	θ > 10 (rank : 107)	NC score	0.061001 (rank : 115)
Query Neighborhood Hits	101	Target Neighborhood Hits	275	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CEND3_MOUSE
θ value	θ > 10 (rank : 108)	NC score	0.059386 (rank : 118)
Query Neighborhood Hits	101	Target Neighborhood Hits	228	Shared Neighborhood Hits	32
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CNKR1_HUMAN
θ value	θ > 10 (rank : 109)	NC score	0.150655 (rank : 46)
Query Neighborhood Hits	101	Target Neighborhood Hits	154	Shared Neighborhood Hits	46
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CNKR2_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.106455 (rank : 69)
Query Neighborhood Hits	101	Target Neighborhood Hits	197	Shared Neighborhood Hits	44
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	θ > 10 (rank : 111)	NC score	0.106570 (rank : 68)
Query Neighborhood Hits	101	Target Neighborhood Hits	197	Shared Neighborhood Hits	44
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

FARP1_HUMAN
θ value	θ > 10 (rank : 112)	NC score	0.065708 (rank : 109)
Query Neighborhood Hits	101	Target Neighborhood Hits	241	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FARP2_HUMAN
θ value	θ > 10 (rank : 113)	NC score	0.060309 (rank : 117)
Query Neighborhood Hits	101	Target Neighborhood Hits	240	Shared Neighborhood Hits	30
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
θ value	θ > 10 (rank : 114)	NC score	0.071271 (rank : 104)
Query Neighborhood Hits	101	Target Neighborhood Hits	209	Shared Neighborhood Hits	37
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FBX8_HUMAN
θ value	θ > 10 (rank : 115)	NC score	0.091339 (rank : 81)
Query Neighborhood Hits	101	Target Neighborhood Hits	44	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NRD0, Q6UWN4, Q9NRP5, Q9UKC4	Gene names	FBXO8, FBS, FBX8
Domain Architecture
Description	F-box only protein 8 (F-box/SEC7 protein FBS).

FBX8_MOUSE
θ value	θ > 10 (rank : 116)	NC score	0.091676 (rank : 80)
Query Neighborhood Hits	101	Target Neighborhood Hits	45	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QZN3	Gene names	Fbxo8, Fbx8
Domain Architecture
Description	F-box only protein 8.

FGD6_MOUSE
θ value	θ > 10 (rank : 117)	NC score	0.055272 (rank : 124)
Query Neighborhood Hits	101	Target Neighborhood Hits	282	Shared Neighborhood Hits	40
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

GAB1_MOUSE
θ value	θ > 10 (rank : 118)	NC score	0.165594 (rank : 41)
Query Neighborhood Hits	101	Target Neighborhood Hits	233	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GBF1_HUMAN
θ value	θ > 10 (rank : 119)	NC score	0.099184 (rank : 74)
Query Neighborhood Hits	101	Target Neighborhood Hits	142	Shared Neighborhood Hits	10
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

IQEC1_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.085695 (rank : 90)
Query Neighborhood Hits	101	Target Neighborhood Hits	76	Shared Neighborhood Hits	11
SwissProt Accessions	Q6DN90, O94863, Q96D85	Gene names	IQSEC1, ARFGEP100, BRAG2, KIAA0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein).

IQEC1_MOUSE
θ value	θ > 10 (rank : 121)	NC score	0.085547 (rank : 91)
Query Neighborhood Hits	101	Target Neighborhood Hits	54	Shared Neighborhood Hits	10
SwissProt Accessions	Q8R0S2, Q3TZC3, Q5DU15	Gene names	Iqsec1, Kiaa0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1.

IQEC2_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.078090 (rank : 96)
Query Neighborhood Hits	101	Target Neighborhood Hits	403	Shared Neighborhood Hits	12
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC2_MOUSE
θ value	θ > 10 (rank : 123)	NC score	0.078410 (rank : 95)
Query Neighborhood Hits	101	Target Neighborhood Hits	417	Shared Neighborhood Hits	12
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC3_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.088483 (rank : 86)
Query Neighborhood Hits	101	Target Neighborhood Hits	125	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

IQEC3_MOUSE
θ value	θ > 10 (rank : 125)	NC score	0.088092 (rank : 87)
Query Neighborhood Hits	101	Target Neighborhood Hits	274	Shared Neighborhood Hits	10
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

OSBL3_HUMAN
θ value	θ > 10 (rank : 126)	NC score	0.064262 (rank : 111)
Query Neighborhood Hits	101	Target Neighborhood Hits	93	Shared Neighborhood Hits	35
SwissProt Accessions	Q9H4L5, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9UED6	Gene names	OSBPL3, KIAA0704, ORP3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

OSBL3_MOUSE
θ value	θ > 10 (rank : 127)	NC score	0.065124 (rank : 110)
Query Neighborhood Hits	101	Target Neighborhood Hits	86	Shared Neighborhood Hits	36
SwissProt Accessions	Q9DBS9	Gene names	Osbpl3, Orp3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

OSBL5_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.073724 (rank : 101)
Query Neighborhood Hits	101	Target Neighborhood Hits	117	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H0X9, Q9BZB0, Q9P1Z4	Gene names	OSBPL5, KIAA1534, ORP5
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5).

OSBL5_MOUSE
θ value	θ > 10 (rank : 129)	NC score	0.074643 (rank : 99)
Query Neighborhood Hits	101	Target Neighborhood Hits	77	Shared Neighborhood Hits	18
SwissProt Accessions	Q9ER64, Q8R510, Q99NF5	Gene names	Osbpl5, Obph1, Osbp2
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5) (Oxysterol-binding protein homolog 1).

OSBL7_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.054117 (rank : 126)
Query Neighborhood Hits	101	Target Neighborhood Hits	71	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BZF2	Gene names	OSBPL7, ORP7
Domain Architecture
Description	Oxysterol-binding protein-related protein 7 (OSBP-related protein 7) (ORP-7).

OSBL8_HUMAN
θ value	θ > 10 (rank : 131)	NC score	0.082647 (rank : 93)
Query Neighborhood Hits	101	Target Neighborhood Hits	289	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BZF1, Q8WXP8, Q9P277	Gene names	OSBPL8, KIAA1451, ORP8, OSBP10
Domain Architecture
Description	Oxysterol-binding protein-related protein 8 (OSBP-related protein 8) (ORP-8).

PKHA4_HUMAN
θ value	θ > 10 (rank : 132)	NC score	0.148617 (rank : 48)
Query Neighborhood Hits	101	Target Neighborhood Hits	283	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_MOUSE
θ value	θ > 10 (rank : 133)	NC score	0.159591 (rank : 44)
Query Neighborhood Hits	101	Target Neighborhood Hits	202	Shared Neighborhood Hits	59
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHB2_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.104511 (rank : 70)
Query Neighborhood Hits	101	Target Neighborhood Hits	54	Shared Neighborhood Hits	39
SwissProt Accessions	Q96CS7, Q86W37, Q9BV75, Q9NWK1	Gene names	PLEKHB2, EVT2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

PKHB2_MOUSE
θ value	θ > 10 (rank : 135)	NC score	0.111549 (rank : 64)
Query Neighborhood Hits	101	Target Neighborhood Hits	48	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

PSD3_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.142033 (rank : 50)
Query Neighborhood Hits	101	Target Neighborhood Hits	75	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

PSD4_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.114322 (rank : 62)
Query Neighborhood Hits	101	Target Neighborhood Hits	178	Shared Neighborhood Hits	22
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

RASA2_HUMAN
θ value	θ > 10 (rank : 138)	NC score	0.081673 (rank : 94)
Query Neighborhood Hits	101	Target Neighborhood Hits	157	Shared Neighborhood Hits	34
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RASA2_MOUSE
θ value	θ > 10 (rank : 139)	NC score	0.092981 (rank : 79)
Query Neighborhood Hits	101	Target Neighborhood Hits	159	Shared Neighborhood Hits	35
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

TBCD2_HUMAN
θ value	θ > 10 (rank : 140)	NC score	0.088715 (rank : 84)
Query Neighborhood Hits	101	Target Neighborhood Hits	419	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

Hits sorted by NC score

PLEK2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	101	Target Neighborhood Hits	101	Shared Neighborhood Hits	101
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_MOUSE
NC score	0.996033 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	101	Target Neighborhood Hits	96	Shared Neighborhood Hits	95
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PLEK_MOUSE
NC score	0.898166 (rank : 3)	θ value	2.74572e-65 (rank : 4)
Query Neighborhood Hits	101	Target Neighborhood Hits	109	Shared Neighborhood Hits	72
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

PLEK_HUMAN
NC score	0.896208 (rank : 4)	θ value	1.45591e-66 (rank : 3)
Query Neighborhood Hits	101	Target Neighborhood Hits	110	Shared Neighborhood Hits	72
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PKHA1_MOUSE
NC score	0.501225 (rank : 5)	θ value	8.97725e-08 (rank : 5)
Query Neighborhood Hits	101	Target Neighborhood Hits	120	Shared Neighborhood Hits	68
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_HUMAN
NC score	0.497453 (rank : 6)	θ value	2.61198e-07 (rank : 8)
Query Neighborhood Hits	101	Target Neighborhood Hits	127	Shared Neighborhood Hits	70
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_HUMAN
NC score	0.455347 (rank : 7)	θ value	1.43324e-05 (rank : 9)
Query Neighborhood Hits	101	Target Neighborhood Hits	119	Shared Neighborhood Hits	64
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHA2_MOUSE
NC score	0.448200 (rank : 8)	θ value	5.44631e-05 (rank : 14)
Query Neighborhood Hits	101	Target Neighborhood Hits	116	Shared Neighborhood Hits	65
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

DAPP1_MOUSE
NC score	0.341735 (rank : 9)	θ value	3.19293e-05 (rank : 12)
Query Neighborhood Hits	101	Target Neighborhood Hits	225	Shared Neighborhood Hits	70
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_HUMAN
NC score	0.339111 (rank : 10)	θ value	4.1701e-05 (rank : 13)
Query Neighborhood Hits	101	Target Neighborhood Hits	227	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

CYH4_HUMAN
NC score	0.331024 (rank : 11)	θ value	9.29e-05 (rank : 15)
Query Neighborhood Hits	101	Target Neighborhood Hits	135	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

CYH4_MOUSE
NC score	0.329141 (rank : 12)	θ value	0.00020696 (rank : 16)
Query Neighborhood Hits	101	Target Neighborhood Hits	134	Shared Neighborhood Hits	71
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

CYH3_MOUSE
NC score	0.321727 (rank : 13)	θ value	0.000602161 (rank : 18)
Query Neighborhood Hits	101	Target Neighborhood Hits	148	Shared Neighborhood Hits	74
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

CYH1_HUMAN
NC score	0.306265 (rank : 14)	θ value	0.00509761 (rank : 25)
Query Neighborhood Hits	101	Target Neighborhood Hits	184	Shared Neighborhood Hits	74
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH2_MOUSE
NC score	0.301643 (rank : 15)	θ value	0.00228821 (rank : 24)
Query Neighborhood Hits	101	Target Neighborhood Hits	171	Shared Neighborhood Hits	70
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH2_HUMAN
NC score	0.301622 (rank : 16)	θ value	0.00228821 (rank : 23)
Query Neighborhood Hits	101	Target Neighborhood Hits	175	Shared Neighborhood Hits	70
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH1_MOUSE
NC score	0.300891 (rank : 17)	θ value	0.00509761 (rank : 26)
Query Neighborhood Hits	101	Target Neighborhood Hits	176	Shared Neighborhood Hits	70
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

CYH3_HUMAN
NC score	0.295518 (rank : 18)	θ value	0.0148317 (rank : 35)
Query Neighborhood Hits	101	Target Neighborhood Hits	137	Shared Neighborhood Hits	67
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

PKHA6_HUMAN
NC score	0.281564 (rank : 19)	θ value	0.0736092 (rank : 49)
Query Neighborhood Hits	101	Target Neighborhood Hits	556	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
NC score	0.279861 (rank : 20)	θ value	0.163984 (rank : 55)
Query Neighborhood Hits	101	Target Neighborhood Hits	591	Shared Neighborhood Hits	80
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

3BP2_MOUSE
NC score	0.278018 (rank : 21)	θ value	0.00869519 (rank : 31)
Query Neighborhood Hits	101	Target Neighborhood Hits	142	Shared Neighborhood Hits	30
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

RHG25_HUMAN
NC score	0.274289 (rank : 22)	θ value	2.44474e-05 (rank : 11)
Query Neighborhood Hits	101	Target Neighborhood Hits	550	Shared Neighborhood Hits	77
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

3BP2_HUMAN
NC score	0.270976 (rank : 23)	θ value	0.00665767 (rank : 29)
Query Neighborhood Hits	101	Target Neighborhood Hits	296	Shared Neighborhood Hits	33
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

RHG25_MOUSE
NC score	0.265967 (rank : 24)	θ value	1.87187e-05 (rank : 10)
Query Neighborhood Hits	101	Target Neighborhood Hits	492	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

SWP70_HUMAN
NC score	0.262093 (rank : 25)	θ value	1.53129e-07 (rank : 7)
Query Neighborhood Hits	101	Target Neighborhood Hits	973	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
NC score	0.254698 (rank : 26)	θ value	1.17247e-07 (rank : 6)
Query Neighborhood Hits	101	Target Neighborhood Hits	1097	Shared Neighborhood Hits	72
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

C43BP_MOUSE
NC score	0.240652 (rank : 27)	θ value	0.0252991 (rank : 39)
Query Neighborhood Hits	101	Target Neighborhood Hits	91	Shared Neighborhood Hits	51
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

OSBL9_HUMAN
NC score	0.236187 (rank : 28)	θ value	0.00665767 (rank : 30)
Query Neighborhood Hits	101	Target Neighborhood Hits	138	Shared Neighborhood Hits	49
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

C43BP_HUMAN
NC score	0.224027 (rank : 29)	θ value	0.0961366 (rank : 50)
Query Neighborhood Hits	101	Target Neighborhood Hits	87	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

PKHA3_HUMAN
NC score	0.218846 (rank : 30)	θ value	0.47712 (rank : 64)
Query Neighborhood Hits	101	Target Neighborhood Hits	66	Shared Neighborhood Hits	43
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

OSB11_HUMAN
NC score	0.215772 (rank : 31)	θ value	0.00509761 (rank : 27)
Query Neighborhood Hits	101	Target Neighborhood Hits	60	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BXB4	Gene names	OSBPL11, ORP11, OSBP12
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

OSB11_MOUSE
NC score	0.215710 (rank : 32)	θ value	0.00509761 (rank : 28)
Query Neighborhood Hits	101	Target Neighborhood Hits	71	Shared Neighborhood Hits	30
SwissProt Accessions	Q8CI95	Gene names	Osbpl11
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

PKHA3_MOUSE
NC score	0.215388 (rank : 33)	θ value	0.813845 (rank : 72)
Query Neighborhood Hits	101	Target Neighborhood Hits	67	Shared Neighborhood Hits	44
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

GAB2_MOUSE
NC score	0.206430 (rank : 34)	θ value	0.279714 (rank : 60)
Query Neighborhood Hits	101	Target Neighborhood Hits	220	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

RASA1_HUMAN
NC score	0.204773 (rank : 35)	θ value	0.00134147 (rank : 19)
Query Neighborhood Hits	101	Target Neighborhood Hits	258	Shared Neighborhood Hits	51
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

GAB1_HUMAN
NC score	0.198614 (rank : 36)	θ value	0.365318 (rank : 61)
Query Neighborhood Hits	101	Target Neighborhood Hits	279	Shared Neighborhood Hits	44
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

PKHA5_HUMAN
NC score	0.192778 (rank : 37)	θ value	0.47712 (rank : 65)
Query Neighborhood Hits	101	Target Neighborhood Hits	455	Shared Neighborhood Hits	73
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

GAB2_HUMAN
NC score	0.188426 (rank : 38)	θ value	4.03905 (rank : 89)
Query Neighborhood Hits	101	Target Neighborhood Hits	188	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

OSB10_HUMAN
NC score	0.177075 (rank : 39)	θ value	0.0961366 (rank : 51)
Query Neighborhood Hits	101	Target Neighborhood Hits	55	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BXB5, Q9BTU5	Gene names	OSBPL10, ORP10, OSBP9
Domain Architecture
Description	Oxysterol-binding protein-related protein 10 (OSBP-related protein 10) (ORP-10).

GNRP_HUMAN
NC score	0.176206 (rank : 40)	θ value	0.00175202 (rank : 22)
Query Neighborhood Hits	101	Target Neighborhood Hits	239	Shared Neighborhood Hits	49
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GAB1_MOUSE
NC score	0.165594 (rank : 41)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	101	Target Neighborhood Hits	233	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GNRP_MOUSE
NC score	0.162120 (rank : 42)	θ value	0.0330416 (rank : 41)
Query Neighborhood Hits	101	Target Neighborhood Hits	191	Shared Neighborhood Hits	48
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

CENA2_HUMAN
NC score	0.161427 (rank : 43)	θ value	0.0193708 (rank : 38)
Query Neighborhood Hits	101	Target Neighborhood Hits	83	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

PKHA4_MOUSE
NC score	0.159591 (rank : 44)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	101	Target Neighborhood Hits	202	Shared Neighborhood Hits	59
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

OSBP1_HUMAN
NC score	0.154409 (rank : 45)	θ value	0.0563607 (rank : 47)
Query Neighborhood Hits	101	Target Neighborhood Hits	180	Shared Neighborhood Hits	56
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

CNKR1_HUMAN
NC score	0.150655 (rank : 46)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	101	Target Neighborhood Hits	154	Shared Neighborhood Hits	46
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

PHLB1_MOUSE
NC score	0.149077 (rank : 47)	θ value	0.0736092 (rank : 48)
Query Neighborhood Hits	101	Target Neighborhood Hits	678	Shared Neighborhood Hits	43
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PKHA4_HUMAN
NC score	0.148617 (rank : 48)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	101	Target Neighborhood Hits	283	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

CENB2_HUMAN
NC score	0.146695 (rank : 49)	θ value	0.163984 (rank : 54)
Query Neighborhood Hits	101	Target Neighborhood Hits	425	Shared Neighborhood Hits	48
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

PSD3_HUMAN
NC score	0.142033 (rank : 50)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	101	Target Neighborhood Hits	75	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

MTMRD_HUMAN
NC score	0.137527 (rank : 51)	θ value	0.813845 (rank : 70)
Query Neighborhood Hits	101	Target Neighborhood Hits	135	Shared Neighborhood Hits	56
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

CENA1_HUMAN
NC score	0.133999 (rank : 52)	θ value	0.279714 (rank : 59)
Query Neighborhood Hits	101	Target Neighborhood Hits	87	Shared Neighborhood Hits	35
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

MTMR5_HUMAN
NC score	0.130933 (rank : 53)	θ value	1.38821 (rank : 78)
Query Neighborhood Hits	101	Target Neighborhood Hits	141	Shared Neighborhood Hits	47
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

PHLB2_MOUSE
NC score	0.126423 (rank : 54)	θ value	0.21417 (rank : 57)
Query Neighborhood Hits	101	Target Neighborhood Hits	1016	Shared Neighborhood Hits	50
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

CENB5_HUMAN
NC score	0.125266 (rank : 55)	θ value	0.0148317 (rank : 34)
Query Neighborhood Hits	101	Target Neighborhood Hits	395	Shared Neighborhood Hits	45
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

PSD4_MOUSE
NC score	0.124819 (rank : 56)	θ value	5.27518 (rank : 95)
Query Neighborhood Hits	101	Target Neighborhood Hits	78	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

OSBP2_HUMAN
NC score	0.124356 (rank : 57)	θ value	0.813845 (rank : 71)
Query Neighborhood Hits	101	Target Neighborhood Hits	154	Shared Neighborhood Hits	48
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

PHLB2_HUMAN
NC score	0.122368 (rank : 58)	θ value	0.62314 (rank : 68)
Query Neighborhood Hits	101	Target Neighborhood Hits	964	Shared Neighborhood Hits	48
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

CENA2_MOUSE
NC score	0.119742 (rank : 59)	θ value	0.0252991 (rank : 40)
Query Neighborhood Hits	101	Target Neighborhood Hits	68	Shared Neighborhood Hits	33
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

PHLB1_HUMAN
NC score	0.117130 (rank : 60)	θ value	1.38821 (rank : 79)
Query Neighborhood Hits	101	Target Neighborhood Hits	1038	Shared Neighborhood Hits	42
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

RASA3_HUMAN
NC score	0.116143 (rank : 61)	θ value	0.365318 (rank : 62)
Query Neighborhood Hits	101	Target Neighborhood Hits	166	Shared Neighborhood Hits	40
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

PSD4_HUMAN
NC score	0.114322 (rank : 62)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	101	Target Neighborhood Hits	178	Shared Neighborhood Hits	22
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

CENB1_HUMAN
NC score	0.112232 (rank : 63)	θ value	0.813845 (rank : 69)
Query Neighborhood Hits	101	Target Neighborhood Hits	383	Shared Neighborhood Hits	46
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

PKHB2_MOUSE
NC score	0.111549 (rank : 64)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	101	Target Neighborhood Hits	48	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

MYO10_HUMAN
NC score	0.111079 (rank : 65)	θ value	0.00035302 (rank : 17)
Query Neighborhood Hits	101	Target Neighborhood Hits	920	Shared Neighborhood Hits	76
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

OSBP2_MOUSE
NC score	0.109535 (rank : 66)	θ value	2.36792 (rank : 85)
Query Neighborhood Hits	101	Target Neighborhood Hits	150	Shared Neighborhood Hits	42
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

RASA3_MOUSE
NC score	0.108088 (rank : 67)	θ value	1.06291 (rank : 74)
Query Neighborhood Hits	101	Target Neighborhood Hits	144	Shared Neighborhood Hits	37
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

CNKR2_MOUSE
NC score	0.106570 (rank : 68)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	101	Target Neighborhood Hits	197	Shared Neighborhood Hits	44
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.106455 (rank : 69)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	101	Target Neighborhood Hits	197	Shared Neighborhood Hits	44
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

PKHB2_HUMAN
NC score	0.104511 (rank : 70)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	101	Target Neighborhood Hits	54	Shared Neighborhood Hits	39
SwissProt Accessions	Q96CS7, Q86W37, Q9BV75, Q9NWK1	Gene names	PLEKHB2, EVT2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

PKHB1_MOUSE
NC score	0.104119 (rank : 71)	θ value	1.38821 (rank : 80)
Query Neighborhood Hits	101	Target Neighborhood Hits	47	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

MRIP_HUMAN
NC score	0.100883 (rank : 72)	θ value	3.0926 (rank : 87)
Query Neighborhood Hits	101	Target Neighborhood Hits	578	Shared Neighborhood Hits	52
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

ANLN_HUMAN
NC score	0.099497 (rank : 73)	θ value	1.06291 (rank : 73)
Query Neighborhood Hits	101	Target Neighborhood Hits	222	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NQW6, Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0	Gene names	ANLN
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

GBF1_HUMAN
NC score	0.099184 (rank : 74)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	101	Target Neighborhood Hits	142	Shared Neighborhood Hits	10
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

BIG2_HUMAN
NC score	0.099170 (rank : 75)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	101	Target Neighborhood Hits	66	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

BIG1_HUMAN
NC score	0.098093 (rank : 76)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	101	Target Neighborhood Hits	76	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

MRIP_MOUSE
NC score	0.097726 (rank : 77)	θ value	5.27518 (rank : 93)
Query Neighborhood Hits	101	Target Neighborhood Hits	569	Shared Neighborhood Hits	54
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

PKHB1_HUMAN
NC score	0.093411 (rank : 78)	θ value	5.27518 (rank : 94)
Query Neighborhood Hits	101	Target Neighborhood Hits	46	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

RASA2_MOUSE
NC score	0.092981 (rank : 79)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	101	Target Neighborhood Hits	159	Shared Neighborhood Hits	35
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

FBX8_MOUSE
NC score	0.091676 (rank : 80)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	101	Target Neighborhood Hits	45	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QZN3	Gene names	Fbxo8, Fbx8
Domain Architecture
Description	F-box only protein 8.

FBX8_HUMAN
NC score	0.091339 (rank : 81)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	101	Target Neighborhood Hits	44	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NRD0, Q6UWN4, Q9NRP5, Q9UKC4	Gene names	FBXO8, FBS, FBX8
Domain Architecture
Description	F-box only protein 8 (F-box/SEC7 protein FBS).

DVL3_MOUSE
NC score	0.089279 (rank : 82)	θ value	0.0148317 (rank : 37)
Query Neighborhood Hits	101	Target Neighborhood Hits	198	Shared Neighborhood Hits	14
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_HUMAN
NC score	0.089247 (rank : 83)	θ value	0.0148317 (rank : 36)
Query Neighborhood Hits	101	Target Neighborhood Hits	194	Shared Neighborhood Hits	11
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

TBCD2_HUMAN
NC score	0.088715 (rank : 84)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	101	Target Neighborhood Hits	419	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

DGKH_HUMAN
NC score	0.088500 (rank : 85)	θ value	2.36792 (rank : 82)
Query Neighborhood Hits	101	Target Neighborhood Hits	255	Shared Neighborhood Hits	48
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

IQEC3_HUMAN
NC score	0.088483 (rank : 86)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	101	Target Neighborhood Hits	125	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

IQEC3_MOUSE
NC score	0.088092 (rank : 87)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	101	Target Neighborhood Hits	274	Shared Neighborhood Hits	10
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

ANLN_MOUSE
NC score	0.088079 (rank : 88)	θ value	1.81305 (rank : 81)
Query Neighborhood Hits	101	Target Neighborhood Hits	297	Shared Neighborhood Hits	21
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

CEND2_HUMAN
NC score	0.086385 (rank : 89)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	101	Target Neighborhood Hits	166	Shared Neighborhood Hits	55
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

IQEC1_HUMAN
NC score	0.085695 (rank : 90)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	101	Target Neighborhood Hits	76	Shared Neighborhood Hits	11
SwissProt Accessions	Q6DN90, O94863, Q96D85	Gene names	IQSEC1, ARFGEP100, BRAG2, KIAA0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein).

IQEC1_MOUSE
NC score	0.085547 (rank : 91)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	101	Target Neighborhood Hits	54	Shared Neighborhood Hits	10
SwissProt Accessions	Q8R0S2, Q3TZC3, Q5DU15	Gene names	Iqsec1, Kiaa0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1.

CEND1_HUMAN
NC score	0.083405 (rank : 92)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	101	Target Neighborhood Hits	284	Shared Neighborhood Hits	59
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

OSBL8_HUMAN
NC score	0.082647 (rank : 93)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	101	Target Neighborhood Hits	289	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BZF1, Q8WXP8, Q9P277	Gene names	OSBPL8, KIAA1451, ORP8, OSBP10
Domain Architecture
Description	Oxysterol-binding protein-related protein 8 (OSBP-related protein 8) (ORP-8).

RASA2_HUMAN
NC score	0.081673 (rank : 94)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	101	Target Neighborhood Hits	157	Shared Neighborhood Hits	34
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

IQEC2_MOUSE
NC score	0.078410 (rank : 95)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	101	Target Neighborhood Hits	417	Shared Neighborhood Hits	12
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC2_HUMAN
NC score	0.078090 (rank : 96)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	101	Target Neighborhood Hits	403	Shared Neighborhood Hits	12
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

DOC10_HUMAN
NC score	0.075688 (rank : 97)	θ value	0.62314 (rank : 67)
Query Neighborhood Hits	101	Target Neighborhood Hits	88	Shared Neighborhood Hits	22
SwissProt Accessions	Q96BY6, O75178, Q9NW06, Q9NXI8	Gene names	DOCK10, KIAA0694
Domain Architecture
Description	Dedicator of cytokinesis protein 10 (Protein zizimin 3).

FGD6_HUMAN
NC score	0.075021 (rank : 98)	θ value	0.0563607 (rank : 46)
Query Neighborhood Hits	101	Target Neighborhood Hits	237	Shared Neighborhood Hits	43
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

OSBL5_MOUSE
NC score	0.074643 (rank : 99)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	101	Target Neighborhood Hits	77	Shared Neighborhood Hits	18
SwissProt Accessions	Q9ER64, Q8R510, Q99NF5	Gene names	Osbpl5, Obph1, Osbp2
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5) (Oxysterol-binding protein homolog 1).

RHG12_HUMAN
NC score	0.074351 (rank : 100)	θ value	0.0961366 (rank : 52)
Query Neighborhood Hits	101	Target Neighborhood Hits	190	Shared Neighborhood Hits	12
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

OSBL5_HUMAN
NC score	0.073724 (rank : 101)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	101	Target Neighborhood Hits	117	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H0X9, Q9BZB0, Q9P1Z4	Gene names	OSBPL5, KIAA1534, ORP5
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5).

TARA_MOUSE
NC score	0.072035 (rank : 102)	θ value	4.03905 (rank : 92)
Query Neighborhood Hits	101	Target Neighborhood Hits	1133	Shared Neighborhood Hits	48
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

RHG12_MOUSE
NC score	0.071326 (rank : 103)	θ value	0.365318 (rank : 63)
Query Neighborhood Hits	101	Target Neighborhood Hits	204	Shared Neighborhood Hits	13
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

FARP2_MOUSE
NC score	0.071271 (rank : 104)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	101	Target Neighborhood Hits	209	Shared Neighborhood Hits	37
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

DOCK9_HUMAN
NC score	0.070741 (rank : 105)	θ value	2.36792 (rank : 83)
Query Neighborhood Hits	101	Target Neighborhood Hits	82	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BZ29, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4	Gene names	DOCK9, KIAA1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

DOCK9_MOUSE
NC score	0.070202 (rank : 106)	θ value	2.36792 (rank : 84)
Query Neighborhood Hits	101	Target Neighborhood Hits	79	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BIK4, Q921Y6	Gene names	Dock9, D14Wsu89e, Kiaa1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

PREX1_HUMAN
NC score	0.070072 (rank : 107)	θ value	0.21417 (rank : 58)
Query Neighborhood Hits	101	Target Neighborhood Hits	177	Shared Neighborhood Hits	21
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

RPGF4_MOUSE
NC score	0.069084 (rank : 108)	θ value	0.0431538 (rank : 45)
Query Neighborhood Hits	101	Target Neighborhood Hits	80	Shared Neighborhood Hits	10
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

FARP1_HUMAN
NC score	0.065708 (rank : 109)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	101	Target Neighborhood Hits	241	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

OSBL3_MOUSE
NC score	0.065124 (rank : 110)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	101	Target Neighborhood Hits	86	Shared Neighborhood Hits	36
SwissProt Accessions	Q9DBS9	Gene names	Osbpl3, Orp3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

OSBL3_HUMAN
NC score	0.064262 (rank : 111)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	101	Target Neighborhood Hits	93	Shared Neighborhood Hits	35
SwissProt Accessions	Q9H4L5, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9UED6	Gene names	OSBPL3, KIAA0704, ORP3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

CEND1_MOUSE
NC score	0.063220 (rank : 112)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	101	Target Neighborhood Hits	260	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

AKT2_MOUSE
NC score	0.062564 (rank : 113)	θ value	0.00869519 (rank : 33)
Query Neighborhood Hits	101	Target Neighborhood Hits	875	Shared Neighborhood Hits	42
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT2_HUMAN
NC score	0.062152 (rank : 114)	θ value	0.00869519 (rank : 32)
Query Neighborhood Hits	101	Target Neighborhood Hits	878	Shared Neighborhood Hits	43
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

CEND3_HUMAN
NC score	0.061001 (rank : 115)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	101	Target Neighborhood Hits	275	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

RPGF4_HUMAN
NC score	0.060810 (rank : 116)	θ value	0.47712 (rank : 66)
Query Neighborhood Hits	101	Target Neighborhood Hits	88	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

FARP2_HUMAN
NC score	0.060309 (rank : 117)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	101	Target Neighborhood Hits	240	Shared Neighborhood Hits	30
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

CEND3_MOUSE
NC score	0.059386 (rank : 118)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	101	Target Neighborhood Hits	228	Shared Neighborhood Hits	32
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

AKT3_HUMAN
NC score	0.058325 (rank : 119)	θ value	0.00175202 (rank : 20)
Query Neighborhood Hits	101	Target Neighborhood Hits	872	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
NC score	0.058314 (rank : 120)	θ value	0.00175202 (rank : 21)
Query Neighborhood Hits	101	Target Neighborhood Hits	872	Shared Neighborhood Hits	37
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

TARA_HUMAN
NC score	0.057652 (rank : 121)	θ value	4.03905 (rank : 91)
Query Neighborhood Hits	101	Target Neighborhood Hits	1626	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

AKT1_MOUSE
NC score	0.056958 (rank : 122)	θ value	0.0431538 (rank : 43)
Query Neighborhood Hits	101	Target Neighborhood Hits	878	Shared Neighborhood Hits	48
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

AKT1_HUMAN
NC score	0.056936 (rank : 123)	θ value	0.0431538 (rank : 42)
Query Neighborhood Hits	101	Target Neighborhood Hits	885	Shared Neighborhood Hits	48
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

FGD6_MOUSE
NC score	0.055272 (rank : 124)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	101	Target Neighborhood Hits	282	Shared Neighborhood Hits	40
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

DGKD_HUMAN
NC score	0.054740 (rank : 125)	θ value	8.99809 (rank : 98)
Query Neighborhood Hits	101	Target Neighborhood Hits	231	Shared Neighborhood Hits	27
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

OSBL7_HUMAN
NC score	0.054117 (rank : 126)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	101	Target Neighborhood Hits	71	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BZF2	Gene names	OSBPL7, ORP7
Domain Architecture
Description	Oxysterol-binding protein-related protein 7 (OSBP-related protein 7) (ORP-7).

TIAM1_MOUSE
NC score	0.046182 (rank : 127)	θ value	3.0926 (rank : 88)
Query Neighborhood Hits	101	Target Neighborhood Hits	205	Shared Neighborhood Hits	17
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

RGS6_HUMAN
NC score	0.043894 (rank : 128)	θ value	1.06291 (rank : 75)
Query Neighborhood Hits	101	Target Neighborhood Hits	80	Shared Neighborhood Hits	8
SwissProt Accessions	P49758, O75576, O75577, Q8TE13, Q8TE14, Q8TE15, Q8TE16, Q8TE17, Q8TE18, Q8TE19, Q8TE20, Q8TE21, Q8TE22, Q9Y245, Q9Y647	Gene names	RGS6
Domain Architecture
Description	Regulator of G-protein signaling 6 (RGS6) (S914).

IRS1_HUMAN
NC score	0.043294 (rank : 129)	θ value	3.0926 (rank : 86)
Query Neighborhood Hits	101	Target Neighborhood Hits	109	Shared Neighborhood Hits	15
SwissProt Accessions	P35568	Gene names	IRS1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

FGD5_HUMAN
NC score	0.042253 (rank : 130)	θ value	8.99809 (rank : 99)
Query Neighborhood Hits	101	Target Neighborhood Hits	235	Shared Neighborhood Hits	30
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

RGS6_MOUSE
NC score	0.042230 (rank : 131)	θ value	1.06291 (rank : 76)
Query Neighborhood Hits	101	Target Neighborhood Hits	71	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Z2H2, Q8BGI8	Gene names	Rgs6
Domain Architecture	No domain graphic available
Description	Regulator of G-protein signaling 6 (RGS6).

TIAM1_HUMAN
NC score	0.042145 (rank : 132)	θ value	8.99809 (rank : 101)
Query Neighborhood Hits	101	Target Neighborhood Hits	225	Shared Neighborhood Hits	17
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

DVL2_MOUSE
NC score	0.041158 (rank : 133)	θ value	6.88961 (rank : 97)
Query Neighborhood Hits	101	Target Neighborhood Hits	233	Shared Neighborhood Hits	7
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

IRS1_MOUSE
NC score	0.040102 (rank : 134)	θ value	4.03905 (rank : 90)
Query Neighborhood Hits	101	Target Neighborhood Hits	112	Shared Neighborhood Hits	13
SwissProt Accessions	P35569	Gene names	Irs1, Irs-1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

BMX_HUMAN
NC score	0.038954 (rank : 135)	θ value	0.163984 (rank : 53)
Query Neighborhood Hits	101	Target Neighborhood Hits	942	Shared Neighborhood Hits	44
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
NC score	0.038608 (rank : 136)	θ value	0.0431538 (rank : 44)
Query Neighborhood Hits	101	Target Neighborhood Hits	912	Shared Neighborhood Hits	42
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

SPTN4_HUMAN
NC score	0.035008 (rank : 137)	θ value	0.163984 (rank : 56)
Query Neighborhood Hits	101	Target Neighborhood Hits	570	Shared Neighborhood Hits	23
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

RGS9_HUMAN
NC score	0.030138 (rank : 138)	θ value	5.27518 (rank : 96)
Query Neighborhood Hits	101	Target Neighborhood Hits	64	Shared Neighborhood Hits	9
SwissProt Accessions	O75916, O75573, Q696R2, Q8TD64, Q8TD65, Q9HC32, Q9HC33	Gene names	RGS9
Domain Architecture
Description	Regulator of G-protein signaling 9 (RGS9).

ITK_HUMAN
NC score	0.025652 (rank : 139)	θ value	1.38821 (rank : 77)
Query Neighborhood Hits	101	Target Neighborhood Hits	1016	Shared Neighborhood Hits	32
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

OPA1_MOUSE
NC score	0.008312 (rank : 140)	θ value	8.99809 (rank : 100)
Query Neighborhood Hits	101	Target Neighborhood Hits	79	Shared Neighborhood Hits	3
SwissProt Accessions	P58281, Q3ULA5, Q8BKU7, Q8BLL3, Q8BM08, Q8R3J7	Gene names	Opa1
Domain Architecture
Description	Dynamin-like 120 kDa protein, mitochondrial precursor (Optic atrophy protein 1 homolog) (Large GTP-binding protein) (LargeG) [Contains: Dynamin-like 120 kDa protein, form S1].