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Network neighborhood for query Sequence : GNRP_HUMAN

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GNRP_HUMAN
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

GNRP_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	239	Target Neighborhood Hits	239	Shared Neighborhood Hits	239
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	0 (rank : 2)	NC score	0.978944 (rank : 2)
Query Neighborhood Hits	239	Target Neighborhood Hits	191	Shared Neighborhood Hits	143
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

SOS2_HUMAN
θ value	9.20422e-37 (rank : 3)	NC score	0.664231 (rank : 3)
Query Neighborhood Hits	239	Target Neighborhood Hits	193	Shared Neighborhood Hits	56
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SOS1_MOUSE
θ value	1.20211e-36 (rank : 4)	NC score	0.648322 (rank : 6)
Query Neighborhood Hits	239	Target Neighborhood Hits	281	Shared Neighborhood Hits	56
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS1_HUMAN
θ value	1.57e-36 (rank : 5)	NC score	0.656481 (rank : 4)
Query Neighborhood Hits	239	Target Neighborhood Hits	274	Shared Neighborhood Hits	60
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

RPGF1_HUMAN
θ value	1.24399e-33 (rank : 6)	NC score	0.653143 (rank : 5)
Query Neighborhood Hits	239	Target Neighborhood Hits	262	Shared Neighborhood Hits	24
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

RGL1_MOUSE
θ value	2.77131e-33 (rank : 7)	NC score	0.610784 (rank : 8)
Query Neighborhood Hits	239	Target Neighborhood Hits	42	Shared Neighborhood Hits	25
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL1_HUMAN
θ value	8.06329e-33 (rank : 8)	NC score	0.622290 (rank : 7)
Query Neighborhood Hits	239	Target Neighborhood Hits	43	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

GRP3_HUMAN
θ value	2.12685e-25 (rank : 9)	NC score	0.524678 (rank : 18)
Query Neighborhood Hits	239	Target Neighborhood Hits	131	Shared Neighborhood Hits	29
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

RPGF5_HUMAN
θ value	3.07116e-24 (rank : 10)	NC score	0.571266 (rank : 12)
Query Neighborhood Hits	239	Target Neighborhood Hits	42	Shared Neighborhood Hits	25
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF5_MOUSE
θ value	4.01107e-24 (rank : 11)	NC score	0.562974 (rank : 15)
Query Neighborhood Hits	239	Target Neighborhood Hits	85	Shared Neighborhood Hits	28
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

GNDS_MOUSE
θ value	4.43474e-23 (rank : 12)	NC score	0.575476 (rank : 9)
Query Neighborhood Hits	239	Target Neighborhood Hits	115	Shared Neighborhood Hits	24
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

GNDS_HUMAN
θ value	9.87957e-23 (rank : 13)	NC score	0.564522 (rank : 13)
Query Neighborhood Hits	239	Target Neighborhood Hits	201	Shared Neighborhood Hits	24
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RPGF4_HUMAN
θ value	7.0802e-21 (rank : 14)	NC score	0.522333 (rank : 19)
Query Neighborhood Hits	239	Target Neighborhood Hits	88	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
θ value	3.51386e-20 (rank : 15)	NC score	0.519281 (rank : 21)
Query Neighborhood Hits	239	Target Neighborhood Hits	80	Shared Neighborhood Hits	26
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RGL2_MOUSE
θ value	3.88503e-19 (rank : 16)	NC score	0.574171 (rank : 10)
Query Neighborhood Hits	239	Target Neighborhood Hits	51	Shared Neighborhood Hits	21
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RGDSR_HUMAN
θ value	1.13037e-18 (rank : 17)	NC score	0.563524 (rank : 14)
Query Neighborhood Hits	239	Target Neighborhood Hits	63	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

RPGF2_HUMAN
θ value	1.92812e-18 (rank : 18)	NC score	0.505382 (rank : 22)
Query Neighborhood Hits	239	Target Neighborhood Hits	242	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RGL2_HUMAN
θ value	1.24977e-17 (rank : 19)	NC score	0.574049 (rank : 11)
Query Neighborhood Hits	239	Target Neighborhood Hits	45	Shared Neighborhood Hits	22
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RPGF6_HUMAN
θ value	1.63225e-17 (rank : 20)	NC score	0.485388 (rank : 29)
Query Neighborhood Hits	239	Target Neighborhood Hits	266	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

ABR_HUMAN
θ value	3.07829e-16 (rank : 21)	NC score	0.349998 (rank : 59)
Query Neighborhood Hits	239	Target Neighborhood Hits	166	Shared Neighborhood Hits	59
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

FGD2_MOUSE
θ value	2.60593e-15 (rank : 22)	NC score	0.475940 (rank : 32)
Query Neighborhood Hits	239	Target Neighborhood Hits	163	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

RPGF3_HUMAN
θ value	9.90251e-15 (rank : 23)	NC score	0.487334 (rank : 27)
Query Neighborhood Hits	239	Target Neighborhood Hits	56	Shared Neighborhood Hits	24
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF3_MOUSE
θ value	1.29331e-14 (rank : 24)	NC score	0.469484 (rank : 34)
Query Neighborhood Hits	239	Target Neighborhood Hits	54	Shared Neighborhood Hits	21
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

ITSN1_HUMAN
θ value	2.88119e-14 (rank : 25)	NC score	0.324006 (rank : 70)
Query Neighborhood Hits	239	Target Neighborhood Hits	1757	Shared Neighborhood Hits	133
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

FGD4_HUMAN
θ value	3.76295e-14 (rank : 26)	NC score	0.489140 (rank : 26)
Query Neighborhood Hits	239	Target Neighborhood Hits	219	Shared Neighborhood Hits	83
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

ITSN2_HUMAN
θ value	3.76295e-14 (rank : 27)	NC score	0.336558 (rank : 66)
Query Neighborhood Hits	239	Target Neighborhood Hits	1173	Shared Neighborhood Hits	113
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN1_MOUSE
θ value	4.91457e-14 (rank : 28)	NC score	0.325257 (rank : 69)
Query Neighborhood Hits	239	Target Neighborhood Hits	1669	Shared Neighborhood Hits	130
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

BCR_HUMAN
θ value	1.09485e-13 (rank : 29)	NC score	0.353892 (rank : 57)
Query Neighborhood Hits	239	Target Neighborhood Hits	204	Shared Neighborhood Hits	58
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ECT2_MOUSE
θ value	1.86753e-13 (rank : 30)	NC score	0.532664 (rank : 16)
Query Neighborhood Hits	239	Target Neighborhood Hits	98	Shared Neighborhood Hits	60
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

FGD2_HUMAN
θ value	1.86753e-13 (rank : 31)	NC score	0.489449 (rank : 25)
Query Neighborhood Hits	239	Target Neighborhood Hits	151	Shared Neighborhood Hits	70
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

ITSN2_MOUSE
θ value	4.16044e-13 (rank : 32)	NC score	0.321015 (rank : 71)
Query Neighborhood Hits	239	Target Neighborhood Hits	1371	Shared Neighborhood Hits	121
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ARHGA_HUMAN
θ value	7.09661e-13 (rank : 33)	NC score	0.467490 (rank : 35)
Query Neighborhood Hits	239	Target Neighborhood Hits	187	Shared Neighborhood Hits	64
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ECT2_HUMAN
θ value	1.2105e-12 (rank : 34)	NC score	0.527999 (rank : 17)
Query Neighborhood Hits	239	Target Neighborhood Hits	98	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

FGD6_MOUSE
θ value	1.2105e-12 (rank : 35)	NC score	0.434903 (rank : 43)
Query Neighborhood Hits	239	Target Neighborhood Hits	282	Shared Neighborhood Hits	81
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

NGEF_MOUSE
θ value	3.52202e-12 (rank : 36)	NC score	0.481068 (rank : 30)
Query Neighborhood Hits	239	Target Neighborhood Hits	228	Shared Neighborhood Hits	59
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

FGD4_MOUSE
θ value	6.00763e-12 (rank : 37)	NC score	0.486040 (rank : 28)
Query Neighborhood Hits	239	Target Neighborhood Hits	227	Shared Neighborhood Hits	80
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

ARHGA_MOUSE
θ value	1.02475e-11 (rank : 38)	NC score	0.462904 (rank : 37)
Query Neighborhood Hits	239	Target Neighborhood Hits	125	Shared Neighborhood Hits	59
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

FGD3_MOUSE
θ value	1.02475e-11 (rank : 39)	NC score	0.493849 (rank : 24)
Query Neighborhood Hits	239	Target Neighborhood Hits	257	Shared Neighborhood Hits	72
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD3_HUMAN
θ value	2.28291e-11 (rank : 40)	NC score	0.480701 (rank : 31)
Query Neighborhood Hits	239	Target Neighborhood Hits	249	Shared Neighborhood Hits	60
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD6_HUMAN
θ value	2.28291e-11 (rank : 41)	NC score	0.427581 (rank : 45)
Query Neighborhood Hits	239	Target Neighborhood Hits	237	Shared Neighborhood Hits	88
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

NGEF_HUMAN
θ value	3.89403e-11 (rank : 42)	NC score	0.495835 (rank : 23)
Query Neighborhood Hits	239	Target Neighborhood Hits	166	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

FARP2_MOUSE
θ value	1.9326e-10 (rank : 43)	NC score	0.345352 (rank : 64)
Query Neighborhood Hits	239	Target Neighborhood Hits	209	Shared Neighborhood Hits	90
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

VAV2_HUMAN
θ value	2.52405e-10 (rank : 44)	NC score	0.364485 (rank : 55)
Query Neighborhood Hits	239	Target Neighborhood Hits	453	Shared Neighborhood Hits	67
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

FGD1_MOUSE
θ value	3.29651e-10 (rank : 45)	NC score	0.462709 (rank : 38)
Query Neighborhood Hits	239	Target Neighborhood Hits	387	Shared Neighborhood Hits	76
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ARHG5_HUMAN
θ value	5.62301e-10 (rank : 46)	NC score	0.470069 (rank : 33)
Query Neighborhood Hits	239	Target Neighborhood Hits	172	Shared Neighborhood Hits	57
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

FGD1_HUMAN
θ value	5.62301e-10 (rank : 47)	NC score	0.463663 (rank : 36)
Query Neighborhood Hits	239	Target Neighborhood Hits	367	Shared Neighborhood Hits	78
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

RGNEF_MOUSE
θ value	1.25267e-09 (rank : 48)	NC score	0.312660 (rank : 73)
Query Neighborhood Hits	239	Target Neighborhood Hits	641	Shared Neighborhood Hits	89
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ARHG3_HUMAN
θ value	3.64472e-09 (rank : 49)	NC score	0.441799 (rank : 40)
Query Neighborhood Hits	239	Target Neighborhood Hits	82	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	8.11959e-09 (rank : 50)	NC score	0.440979 (rank : 42)
Query Neighborhood Hits	239	Target Neighborhood Hits	85	Shared Neighborhood Hits	52
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

VAV2_MOUSE
θ value	8.11959e-09 (rank : 51)	NC score	0.362422 (rank : 56)
Query Neighborhood Hits	239	Target Neighborhood Hits	456	Shared Neighborhood Hits	69
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV_HUMAN
θ value	1.06045e-08 (rank : 52)	NC score	0.325372 (rank : 68)
Query Neighborhood Hits	239	Target Neighborhood Hits	452	Shared Neighborhood Hits	67
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

PREX1_HUMAN
θ value	1.38499e-08 (rank : 53)	NC score	0.521983 (rank : 20)
Query Neighborhood Hits	239	Target Neighborhood Hits	177	Shared Neighborhood Hits	75
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ARHGF_HUMAN
θ value	2.36244e-08 (rank : 54)	NC score	0.429546 (rank : 44)
Query Neighborhood Hits	239	Target Neighborhood Hits	214	Shared Neighborhood Hits	50
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGG_MOUSE
θ value	4.0297e-08 (rank : 55)	NC score	0.449808 (rank : 39)
Query Neighborhood Hits	239	Target Neighborhood Hits	152	Shared Neighborhood Hits	55
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

DNMBP_MOUSE
θ value	6.87365e-08 (rank : 56)	NC score	0.347843 (rank : 61)
Query Neighborhood Hits	239	Target Neighborhood Hits	435	Shared Neighborhood Hits	63
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

FARP1_HUMAN
θ value	8.97725e-08 (rank : 57)	NC score	0.287281 (rank : 82)
Query Neighborhood Hits	239	Target Neighborhood Hits	241	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

TIAM1_HUMAN
θ value	1.53129e-07 (rank : 58)	NC score	0.422390 (rank : 49)
Query Neighborhood Hits	239	Target Neighborhood Hits	225	Shared Neighborhood Hits	75
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	1.53129e-07 (rank : 59)	NC score	0.424403 (rank : 48)
Query Neighborhood Hits	239	Target Neighborhood Hits	205	Shared Neighborhood Hits	75
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG7_HUMAN
θ value	1.29631e-06 (rank : 60)	NC score	0.349872 (rank : 60)
Query Neighborhood Hits	239	Target Neighborhood Hits	347	Shared Neighborhood Hits	69
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHGG_HUMAN
θ value	1.29631e-06 (rank : 61)	NC score	0.441077 (rank : 41)
Query Neighborhood Hits	239	Target Neighborhood Hits	129	Shared Neighborhood Hits	56
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

VAV3_MOUSE
θ value	1.69304e-06 (rank : 62)	NC score	0.346860 (rank : 62)
Query Neighborhood Hits	239	Target Neighborhood Hits	404	Shared Neighborhood Hits	63
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_MOUSE
θ value	1.69304e-06 (rank : 63)	NC score	0.330545 (rank : 67)
Query Neighborhood Hits	239	Target Neighborhood Hits	430	Shared Neighborhood Hits	64
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ARHGB_HUMAN
θ value	2.21117e-06 (rank : 64)	NC score	0.352634 (rank : 58)
Query Neighborhood Hits	239	Target Neighborhood Hits	375	Shared Neighborhood Hits	64
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHG8_HUMAN
θ value	3.77169e-06 (rank : 65)	NC score	0.425636 (rank : 46)
Query Neighborhood Hits	239	Target Neighborhood Hits	85	Shared Neighborhood Hits	54
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG4_HUMAN
θ value	4.92598e-06 (rank : 66)	NC score	0.425231 (rank : 47)
Query Neighborhood Hits	239	Target Neighborhood Hits	242	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG7_MOUSE
θ value	4.92598e-06 (rank : 67)	NC score	0.345437 (rank : 63)
Query Neighborhood Hits	239	Target Neighborhood Hits	396	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG8_MOUSE
θ value	8.40245e-06 (rank : 68)	NC score	0.398141 (rank : 53)
Query Neighborhood Hits	239	Target Neighborhood Hits	79	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

VAV3_HUMAN
θ value	1.87187e-05 (rank : 69)	NC score	0.340445 (rank : 65)
Query Neighborhood Hits	239	Target Neighborhood Hits	398	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

CYH4_HUMAN
θ value	4.1701e-05 (rank : 70)	NC score	0.163528 (rank : 95)
Query Neighborhood Hits	239	Target Neighborhood Hits	135	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

SWP70_MOUSE
θ value	7.1131e-05 (rank : 71)	NC score	0.144054 (rank : 110)
Query Neighborhood Hits	239	Target Neighborhood Hits	1097	Shared Neighborhood Hits	119
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

DUET_HUMAN
θ value	0.000121331 (rank : 72)	NC score	0.117994 (rank : 120)
Query Neighborhood Hits	239	Target Neighborhood Hits	1220	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

SWP70_HUMAN
θ value	0.000121331 (rank : 73)	NC score	0.149568 (rank : 102)
Query Neighborhood Hits	239	Target Neighborhood Hits	973	Shared Neighborhood Hits	115
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

CYH4_MOUSE
θ value	0.000158464 (rank : 74)	NC score	0.162353 (rank : 97)
Query Neighborhood Hits	239	Target Neighborhood Hits	134	Shared Neighborhood Hits	54
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

DNMBP_HUMAN
θ value	0.000270298 (rank : 75)	NC score	0.317473 (rank : 72)
Query Neighborhood Hits	239	Target Neighborhood Hits	413	Shared Neighborhood Hits	66
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

PKHA6_MOUSE
θ value	0.000461057 (rank : 76)	NC score	0.192919 (rank : 91)
Query Neighborhood Hits	239	Target Neighborhood Hits	591	Shared Neighborhood Hits	97
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

CYH3_MOUSE
θ value	0.00134147 (rank : 77)	NC score	0.157615 (rank : 100)
Query Neighborhood Hits	239	Target Neighborhood Hits	148	Shared Neighborhood Hits	59
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

DAPP1_MOUSE
θ value	0.00134147 (rank : 78)	NC score	0.137850 (rank : 113)
Query Neighborhood Hits	239	Target Neighborhood Hits	225	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

ARHG6_HUMAN
θ value	0.00175202 (rank : 79)	NC score	0.307615 (rank : 74)
Query Neighborhood Hits	239	Target Neighborhood Hits	376	Shared Neighborhood Hits	70
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

CYH3_HUMAN
θ value	0.00175202 (rank : 80)	NC score	0.147871 (rank : 106)
Query Neighborhood Hits	239	Target Neighborhood Hits	137	Shared Neighborhood Hits	50
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

DAPP1_HUMAN
θ value	0.00175202 (rank : 81)	NC score	0.136032 (rank : 116)
Query Neighborhood Hits	239	Target Neighborhood Hits	227	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PLEK2_HUMAN
θ value	0.00175202 (rank : 82)	NC score	0.176206 (rank : 93)
Query Neighborhood Hits	239	Target Neighborhood Hits	101	Shared Neighborhood Hits	49
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PKHA6_HUMAN
θ value	0.00228821 (rank : 83)	NC score	0.186622 (rank : 92)
Query Neighborhood Hits	239	Target Neighborhood Hits	556	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

OSB11_HUMAN
θ value	0.00298849 (rank : 84)	NC score	0.092706 (rank : 140)
Query Neighborhood Hits	239	Target Neighborhood Hits	60	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BXB4	Gene names	OSBPL11, ORP11, OSBP12
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

OSB11_MOUSE
θ value	0.00298849 (rank : 85)	NC score	0.094790 (rank : 136)
Query Neighborhood Hits	239	Target Neighborhood Hits	71	Shared Neighborhood Hits	28
SwissProt Accessions	Q8CI95	Gene names	Osbpl11
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

PLEK2_MOUSE
θ value	0.00298849 (rank : 86)	NC score	0.169383 (rank : 94)
Query Neighborhood Hits	239	Target Neighborhood Hits	96	Shared Neighborhood Hits	48
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

ARHG6_MOUSE
θ value	0.00390308 (rank : 87)	NC score	0.292077 (rank : 81)
Query Neighborhood Hits	239	Target Neighborhood Hits	394	Shared Neighborhood Hits	74
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

PKHA5_HUMAN
θ value	0.00390308 (rank : 88)	NC score	0.150324 (rank : 101)
Query Neighborhood Hits	239	Target Neighborhood Hits	455	Shared Neighborhood Hits	91
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

GOGA4_MOUSE
θ value	0.00509761 (rank : 89)	NC score	0.061966 (rank : 239)
Query Neighborhood Hits	239	Target Neighborhood Hits	1939	Shared Neighborhood Hits	89
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

CYH2_HUMAN
θ value	0.00665767 (rank : 90)	NC score	0.147680 (rank : 107)
Query Neighborhood Hits	239	Target Neighborhood Hits	175	Shared Neighborhood Hits	58
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	0.00665767 (rank : 91)	NC score	0.147296 (rank : 108)
Query Neighborhood Hits	239	Target Neighborhood Hits	171	Shared Neighborhood Hits	55
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

RHG25_HUMAN
θ value	0.00665767 (rank : 92)	NC score	0.139134 (rank : 112)
Query Neighborhood Hits	239	Target Neighborhood Hits	550	Shared Neighborhood Hits	106
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

CYH1_HUMAN
θ value	0.0113563 (rank : 93)	NC score	0.145699 (rank : 109)
Query Neighborhood Hits	239	Target Neighborhood Hits	184	Shared Neighborhood Hits	63
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
θ value	0.0113563 (rank : 94)	NC score	0.143737 (rank : 111)
Query Neighborhood Hits	239	Target Neighborhood Hits	176	Shared Neighborhood Hits	61
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

GOGA4_HUMAN
θ value	0.0113563 (rank : 95)	NC score	0.064624 (rank : 225)
Query Neighborhood Hits	239	Target Neighborhood Hits	2034	Shared Neighborhood Hits	95
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

PLEK_MOUSE
θ value	0.0252991 (rank : 96)	NC score	0.163064 (rank : 96)
Query Neighborhood Hits	239	Target Neighborhood Hits	109	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

RHG25_MOUSE
θ value	0.0252991 (rank : 97)	NC score	0.136550 (rank : 115)
Query Neighborhood Hits	239	Target Neighborhood Hits	492	Shared Neighborhood Hits	94
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

MYO10_HUMAN
θ value	0.0330416 (rank : 98)	NC score	0.066481 (rank : 213)
Query Neighborhood Hits	239	Target Neighborhood Hits	920	Shared Neighborhood Hits	102
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

CJ118_MOUSE
θ value	0.0563607 (rank : 99)	NC score	0.056167 (rank : 276)
Query Neighborhood Hits	239	Target Neighborhood Hits	1132	Shared Neighborhood Hits	77
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

AZI1_HUMAN
θ value	0.0736092 (rank : 100)	NC score	0.075423 (rank : 170)
Query Neighborhood Hits	239	Target Neighborhood Hits	1000	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

NEMO_MOUSE
θ value	0.0736092 (rank : 101)	NC score	0.054193 (rank : 293)
Query Neighborhood Hits	239	Target Neighborhood Hits	658	Shared Neighborhood Hits	60
SwissProt Accessions	O88522	Gene names	Ikbkg, Nemo
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3).

PKHA4_MOUSE
θ value	0.0736092 (rank : 102)	NC score	0.157877 (rank : 99)
Query Neighborhood Hits	239	Target Neighborhood Hits	202	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PLEK_HUMAN
θ value	0.0736092 (rank : 103)	NC score	0.159033 (rank : 98)
Query Neighborhood Hits	239	Target Neighborhood Hits	110	Shared Neighborhood Hits	48
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

HAPIP_HUMAN
θ value	0.0961366 (rank : 104)	NC score	0.276021 (rank : 88)
Query Neighborhood Hits	239	Target Neighborhood Hits	350	Shared Neighborhood Hits	95
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

K1914_HUMAN
θ value	0.0961366 (rank : 105)	NC score	0.078464 (rank : 163)
Query Neighborhood Hits	239	Target Neighborhood Hits	255	Shared Neighborhood Hits	52
SwissProt Accessions	Q8N4X5, Q8TB54, Q96PX4, Q96SY5	Gene names	KIAA1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

AZI1_MOUSE
θ value	0.125558 (rank : 106)	NC score	0.071875 (rank : 187)
Query Neighborhood Hits	239	Target Neighborhood Hits	990	Shared Neighborhood Hits	79
SwissProt Accessions	Q62036	Gene names	Azi1, Az1, Azi
Domain Architecture
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1).

CENPF_HUMAN
θ value	0.125558 (rank : 107)	NC score	0.061921 (rank : 240)
Query Neighborhood Hits	239	Target Neighborhood Hits	1932	Shared Neighborhood Hits	99
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

KIF1B_HUMAN
θ value	0.125558 (rank : 108)	NC score	0.019106 (rank : 405)
Query Neighborhood Hits	239	Target Neighborhood Hits	178	Shared Neighborhood Hits	23
SwissProt Accessions	O60333, Q96Q94, Q9BV80, Q9P280	Gene names	KIF1B, KIAA0591, KIAA1448
Domain Architecture
Description	Kinesin-like protein KIF1B (Klp).

KTN1_HUMAN
θ value	0.125558 (rank : 109)	NC score	0.057835 (rank : 265)
Query Neighborhood Hits	239	Target Neighborhood Hits	1197	Shared Neighborhood Hits	85
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

PKHA4_HUMAN
θ value	0.125558 (rank : 110)	NC score	0.148804 (rank : 103)
Query Neighborhood Hits	239	Target Neighborhood Hits	283	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

3BP2_MOUSE
θ value	0.163984 (rank : 111)	NC score	0.127276 (rank : 118)
Query Neighborhood Hits	239	Target Neighborhood Hits	142	Shared Neighborhood Hits	37
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

3BP2_HUMAN
θ value	0.21417 (rank : 112)	NC score	0.124888 (rank : 119)
Query Neighborhood Hits	239	Target Neighborhood Hits	296	Shared Neighborhood Hits	39
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

UACA_MOUSE
θ value	0.21417 (rank : 113)	NC score	0.043376 (rank : 377)
Query Neighborhood Hits	239	Target Neighborhood Hits	1620	Shared Neighborhood Hits	81
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

BPAEA_HUMAN
θ value	0.279714 (rank : 114)	NC score	0.045401 (rank : 372)
Query Neighborhood Hits	239	Target Neighborhood Hits	1369	Shared Neighborhood Hits	82
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

CP250_HUMAN
θ value	0.279714 (rank : 115)	NC score	0.057055 (rank : 267)
Query Neighborhood Hits	239	Target Neighborhood Hits	1805	Shared Neighborhood Hits	91
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

ODO1_MOUSE
θ value	0.279714 (rank : 116)	NC score	0.049597 (rank : 360)
Query Neighborhood Hits	239	Target Neighborhood Hits	21	Shared Neighborhood Hits	5
SwissProt Accessions	Q60597, Q80Y57, Q8K2Z3	Gene names	Ogdh
Domain Architecture
Description	2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase).

EEA1_MOUSE
θ value	0.365318 (rank : 117)	NC score	0.079223 (rank : 158)
Query Neighborhood Hits	239	Target Neighborhood Hits	1637	Shared Neighborhood Hits	100
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

MYH14_HUMAN
θ value	0.365318 (rank : 118)	NC score	0.041118 (rank : 382)
Query Neighborhood Hits	239	Target Neighborhood Hits	995	Shared Neighborhood Hits	72
SwissProt Accessions	Q7Z406, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882	Gene names	MYH14, KIAA2034
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

ODO1_HUMAN
θ value	0.365318 (rank : 119)	NC score	0.048094 (rank : 363)
Query Neighborhood Hits	239	Target Neighborhood Hits	18	Shared Neighborhood Hits	5
SwissProt Accessions	Q02218	Gene names	OGDH
Domain Architecture
Description	2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase).

CEND2_HUMAN
θ value	0.47712 (rank : 120)	NC score	0.062489 (rank : 235)
Query Neighborhood Hits	239	Target Neighborhood Hits	166	Shared Neighborhood Hits	46
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

MYH6_MOUSE
θ value	0.47712 (rank : 121)	NC score	0.047043 (rank : 366)
Query Neighborhood Hits	239	Target Neighborhood Hits	1501	Shared Neighborhood Hits	88
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

NUAK2_MOUSE
θ value	0.47712 (rank : 122)	NC score	-0.003468 (rank : 444)
Query Neighborhood Hits	239	Target Neighborhood Hits	878	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

TACC3_HUMAN
θ value	0.47712 (rank : 123)	NC score	0.041588 (rank : 380)
Query Neighborhood Hits	239	Target Neighborhood Hits	779	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

ANK2_HUMAN
θ value	0.62314 (rank : 124)	NC score	0.021532 (rank : 403)
Query Neighborhood Hits	239	Target Neighborhood Hits	1615	Shared Neighborhood Hits	63
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

C43BP_MOUSE
θ value	0.62314 (rank : 125)	NC score	0.087252 (rank : 146)
Query Neighborhood Hits	239	Target Neighborhood Hits	91	Shared Neighborhood Hits	35
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

K1914_MOUSE
θ value	0.62314 (rank : 126)	NC score	0.061288 (rank : 245)
Query Neighborhood Hits	239	Target Neighborhood Hits	216	Shared Neighborhood Hits	38
SwissProt Accessions	Q5DTU0, Q8BID1, Q8K2G0	Gene names	Kiaa1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

MYH6_HUMAN
θ value	0.62314 (rank : 127)	NC score	0.045568 (rank : 370)
Query Neighborhood Hits	239	Target Neighborhood Hits	1426	Shared Neighborhood Hits	85
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH7_HUMAN
θ value	0.62314 (rank : 128)	NC score	0.046632 (rank : 367)
Query Neighborhood Hits	239	Target Neighborhood Hits	1559	Shared Neighborhood Hits	92
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

AN30A_HUMAN
θ value	0.813845 (rank : 129)	NC score	0.041837 (rank : 379)
Query Neighborhood Hits	239	Target Neighborhood Hits	1119	Shared Neighborhood Hits	73
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

OSB10_HUMAN
θ value	0.813845 (rank : 130)	NC score	0.061391 (rank : 244)
Query Neighborhood Hits	239	Target Neighborhood Hits	55	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BXB5, Q9BTU5	Gene names	OSBPL10, ORP10, OSBP9
Domain Architecture
Description	Oxysterol-binding protein-related protein 10 (OSBP-related protein 10) (ORP-10).

RBP1_HUMAN
θ value	0.813845 (rank : 131)	NC score	0.063941 (rank : 229)
Query Neighborhood Hits	239	Target Neighborhood Hits	521	Shared Neighborhood Hits	62
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

CENA1_HUMAN
θ value	1.06291 (rank : 132)	NC score	0.055646 (rank : 280)
Query Neighborhood Hits	239	Target Neighborhood Hits	87	Shared Neighborhood Hits	32
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

KIF3C_HUMAN
θ value	1.06291 (rank : 133)	NC score	0.024839 (rank : 398)
Query Neighborhood Hits	239	Target Neighborhood Hits	478	Shared Neighborhood Hits	61
SwissProt Accessions	O14782, O43544	Gene names	KIF3C
Domain Architecture
Description	Kinesin-like protein KIF3C.

LRCH1_MOUSE
θ value	1.06291 (rank : 134)	NC score	0.028893 (rank : 394)
Query Neighborhood Hits	239	Target Neighborhood Hits	264	Shared Neighborhood Hits	15
SwissProt Accessions	P62046	Gene names	Lrch1, Chdc1, Kiaa1016
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1).

PDE1B_HUMAN
θ value	1.06291 (rank : 135)	NC score	0.014509 (rank : 409)
Query Neighborhood Hits	239	Target Neighborhood Hits	50	Shared Neighborhood Hits	5
SwissProt Accessions	Q01064, Q92825	Gene names	PDE1B, PDE1B1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PIBF1_HUMAN
θ value	1.06291 (rank : 136)	NC score	0.059167 (rank : 256)
Query Neighborhood Hits	239	Target Neighborhood Hits	1041	Shared Neighborhood Hits	80
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

PK1IP_MOUSE
θ value	1.06291 (rank : 137)	NC score	0.006356 (rank : 430)
Query Neighborhood Hits	239	Target Neighborhood Hits	313	Shared Neighborhood Hits	2
SwissProt Accessions	Q9DCE5, Q3UBK7, Q80UT4, Q8C5N6, Q923K2, Q9D3E9	Gene names	Pak1ip1
Domain Architecture	No domain graphic available
Description	p21-activated protein kinase-interacting protein 1 (PAK1-interacting protein 1) (Putative PAK inhibitor Skb15).

RBP1_MOUSE
θ value	1.06291 (rank : 138)	NC score	0.063701 (rank : 230)
Query Neighborhood Hits	239	Target Neighborhood Hits	493	Shared Neighborhood Hits	59
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

SPNXE_HUMAN
θ value	1.06291 (rank : 139)	NC score	0.030969 (rank : 390)
Query Neighborhood Hits	239	Target Neighborhood Hits	6	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TAD1, Q9BS24	Gene names	SPANXE
Domain Architecture	No domain graphic available
Description	Sperm protein associated with the nucleus on the X chromosome E (Nuclear-associated protein SPAN-Xe).

BICD1_MOUSE
θ value	1.38821 (rank : 140)	NC score	0.056610 (rank : 271)
Query Neighborhood Hits	239	Target Neighborhood Hits	837	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BR07, O55206, Q8BQ18, Q8BRR8, Q8C4D3, Q8CAK6, Q8R2J4, Q8R2J5, Q8R2J6, Q91YP7	Gene names	Bicd1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

C43BP_HUMAN
θ value	1.38821 (rank : 141)	NC score	0.082293 (rank : 156)
Query Neighborhood Hits	239	Target Neighborhood Hits	87	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

DJBP_HUMAN
θ value	1.38821 (rank : 142)	NC score	0.016483 (rank : 406)
Query Neighborhood Hits	239	Target Neighborhood Hits	156	Shared Neighborhood Hits	3
SwissProt Accessions	Q5THR3, Q5U5T6, Q9BY88, Q9H5C4, Q9NSF5	Gene names	DJBP, KIAA1672
Domain Architecture	No domain graphic available
Description	DJ-1-binding protein (CAP-binding protein complex-interacting protein 1).

FES_MOUSE
θ value	1.38821 (rank : 143)	NC score	-0.003208 (rank : 442)
Query Neighborhood Hits	239	Target Neighborhood Hits	980	Shared Neighborhood Hits	26
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

LRCH1_HUMAN
θ value	1.38821 (rank : 144)	NC score	0.028968 (rank : 393)
Query Neighborhood Hits	239	Target Neighborhood Hits	266	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y2L9, Q7Z5F6, Q7Z5F7	Gene names	LRCH1, CHDC1, KIAA1016
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1) (Neuronal protein 81) (NP81).

REST_MOUSE
θ value	1.38821 (rank : 145)	NC score	0.049774 (rank : 359)
Query Neighborhood Hits	239	Target Neighborhood Hits	1506	Shared Neighborhood Hits	87
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

AKAP9_HUMAN
θ value	1.81305 (rank : 146)	NC score	0.054460 (rank : 290)
Query Neighborhood Hits	239	Target Neighborhood Hits	1710	Shared Neighborhood Hits	94
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

ATBF1_MOUSE
θ value	1.81305 (rank : 147)	NC score	0.004152 (rank : 434)
Query Neighborhood Hits	239	Target Neighborhood Hits	1841	Shared Neighborhood Hits	31
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

BACH1_MOUSE
θ value	1.81305 (rank : 148)	NC score	0.005719 (rank : 431)
Query Neighborhood Hits	239	Target Neighborhood Hits	289	Shared Neighborhood Hits	14
SwissProt Accessions	P97302	Gene names	Bach1
Domain Architecture
Description	Transcription regulator protein BACH1 (BTB and CNC homolog 1).

CENA2_HUMAN
θ value	1.81305 (rank : 149)	NC score	0.046328 (rank : 368)
Query Neighborhood Hits	239	Target Neighborhood Hits	83	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

DGKH_HUMAN
θ value	1.81305 (rank : 150)	NC score	0.069427 (rank : 197)
Query Neighborhood Hits	239	Target Neighborhood Hits	255	Shared Neighborhood Hits	53
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

PKHB1_HUMAN
θ value	1.81305 (rank : 151)	NC score	0.063315 (rank : 232)
Query Neighborhood Hits	239	Target Neighborhood Hits	46	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

STAP1_MOUSE
θ value	1.81305 (rank : 152)	NC score	0.032465 (rank : 387)
Query Neighborhood Hits	239	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JM90, Q3TRM1, Q6PES6	Gene names	Stap1
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 1 (STAP-1) (Stem cell adaptor protein 1).

WRB_HUMAN
θ value	1.81305 (rank : 153)	NC score	0.032094 (rank : 389)
Query Neighborhood Hits	239	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	O00258, O60740	Gene names	WRB, CHD5
Domain Architecture
Description	Tryptophan-rich protein (Congenital heart disease 5 protein).

WRB_MOUSE
θ value	1.81305 (rank : 154)	NC score	0.032150 (rank : 388)
Query Neighborhood Hits	239	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K0D7, Q3TA55, Q9D1W0	Gene names	Wrb
Domain Architecture	No domain graphic available
Description	Tryptophan-rich protein.

ANR18_HUMAN
θ value	2.36792 (rank : 155)	NC score	0.037009 (rank : 385)
Query Neighborhood Hits	239	Target Neighborhood Hits	1106	Shared Neighborhood Hits	79
SwissProt Accessions	Q8IVF6, Q7Z468	Gene names	ANKRD18A, KIAA2015
Domain Architecture
Description	Ankyrin repeat domain-containing protein 18A.

BICD1_HUMAN
θ value	2.36792 (rank : 156)	NC score	0.052775 (rank : 307)
Query Neighborhood Hits	239	Target Neighborhood Hits	844	Shared Neighborhood Hits	69
SwissProt Accessions	Q96G01, O43892, O43893	Gene names	BICD1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

CNKR2_HUMAN
θ value	2.36792 (rank : 157)	NC score	0.083425 (rank : 153)
Query Neighborhood Hits	239	Target Neighborhood Hits	197	Shared Neighborhood Hits	40
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	2.36792 (rank : 158)	NC score	0.083434 (rank : 152)
Query Neighborhood Hits	239	Target Neighborhood Hits	197	Shared Neighborhood Hits	39
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

EPN2_HUMAN
θ value	2.36792 (rank : 159)	NC score	0.015255 (rank : 408)
Query Neighborhood Hits	239	Target Neighborhood Hits	156	Shared Neighborhood Hits	9
SwissProt Accessions	O95208, O95207, Q9H7Z2, Q9UPT7	Gene names	EPN2, KIAA1065
Domain Architecture
Description	Epsin-2 (EPS-15-interacting protein 2).

GOGA5_MOUSE
θ value	2.36792 (rank : 160)	NC score	0.053682 (rank : 297)
Query Neighborhood Hits	239	Target Neighborhood Hits	1434	Shared Neighborhood Hits	92
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

GOGB1_HUMAN
θ value	2.36792 (rank : 161)	NC score	0.056744 (rank : 270)
Query Neighborhood Hits	239	Target Neighborhood Hits	2297	Shared Neighborhood Hits	115
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

IRX1_HUMAN
θ value	2.36792 (rank : 162)	NC score	0.010301 (rank : 420)
Query Neighborhood Hits	239	Target Neighborhood Hits	285	Shared Neighborhood Hits	4
SwissProt Accessions	P78414, Q7Z2F8, Q8N312	Gene names	IRX1, IRXA1
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-1 (Iroquois homeobox protein 1) (Homeodomain protein IRXA1).

PDE1B_MOUSE
θ value	2.36792 (rank : 163)	NC score	0.013114 (rank : 415)
Query Neighborhood Hits	239	Target Neighborhood Hits	46	Shared Neighborhood Hits	4
SwissProt Accessions	Q01065, O35384	Gene names	Pde1b, Pde1b1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

SPTB2_HUMAN
θ value	2.36792 (rank : 164)	NC score	0.051321 (rank : 325)
Query Neighborhood Hits	239	Target Neighborhood Hits	748	Shared Neighborhood Hits	87
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

FGD5_MOUSE
θ value	3.0926 (rank : 165)	NC score	0.294328 (rank : 80)
Query Neighborhood Hits	239	Target Neighborhood Hits	170	Shared Neighborhood Hits	66
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

K2C4_HUMAN
θ value	3.0926 (rank : 166)	NC score	0.013682 (rank : 411)
Query Neighborhood Hits	239	Target Neighborhood Hits	471	Shared Neighborhood Hits	58
SwissProt Accessions	P19013, Q6GTR8, Q96LA7, Q9BTL1	Gene names	KRT4, CYK4
Domain Architecture
Description	Keratin, type II cytoskeletal 4 (Cytokeratin-4) (CK-4) (Keratin-4) (K4).

KIF3A_HUMAN
θ value	3.0926 (rank : 167)	NC score	0.026499 (rank : 397)
Query Neighborhood Hits	239	Target Neighborhood Hits	704	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Y496, Q86XE9, Q9Y6V4	Gene names	KIF3A, KIF3
Domain Architecture
Description	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A).

KIF3A_MOUSE
θ value	3.0926 (rank : 168)	NC score	0.027351 (rank : 396)
Query Neighborhood Hits	239	Target Neighborhood Hits	715	Shared Neighborhood Hits	69
SwissProt Accessions	P28741	Gene names	Kif3a, Kif3
Domain Architecture
Description	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A).

LAMB1_HUMAN
θ value	3.0926 (rank : 169)	NC score	0.019485 (rank : 404)
Query Neighborhood Hits	239	Target Neighborhood Hits	1018	Shared Neighborhood Hits	68
SwissProt Accessions	P07942	Gene names	LAMB1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

PKHA3_MOUSE
θ value	3.0926 (rank : 170)	NC score	0.085264 (rank : 149)
Query Neighborhood Hits	239	Target Neighborhood Hits	67	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

ANDR_HUMAN
θ value	4.03905 (rank : 171)	NC score	0.001933 (rank : 439)
Query Neighborhood Hits	239	Target Neighborhood Hits	126	Shared Neighborhood Hits	3
SwissProt Accessions	P10275	Gene names	AR, DHTR, NR3C4
Domain Architecture
Description	Androgen receptor (Dihydrotestosterone receptor).

ATBF1_HUMAN
θ value	4.03905 (rank : 172)	NC score	0.000163 (rank : 441)
Query Neighborhood Hits	239	Target Neighborhood Hits	1547	Shared Neighborhood Hits	18
SwissProt Accessions	Q15911, O15101, Q13719	Gene names	ATBF1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

BICD2_MOUSE
θ value	4.03905 (rank : 173)	NC score	0.053804 (rank : 296)
Query Neighborhood Hits	239	Target Neighborhood Hits	864	Shared Neighborhood Hits	75
SwissProt Accessions	Q921C5, Q80TU1, Q8BTE3, Q9DCL3	Gene names	Bicd2, Kiaa0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

CENB2_HUMAN
θ value	4.03905 (rank : 174)	NC score	0.050388 (rank : 346)
Query Neighborhood Hits	239	Target Neighborhood Hits	425	Shared Neighborhood Hits	56
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CK5P2_MOUSE
θ value	4.03905 (rank : 175)	NC score	0.050721 (rank : 335)
Query Neighborhood Hits	239	Target Neighborhood Hits	1151	Shared Neighborhood Hits	80
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

DHX34_MOUSE
θ value	4.03905 (rank : 176)	NC score	0.003825 (rank : 435)
Query Neighborhood Hits	239	Target Neighborhood Hits	235	Shared Neighborhood Hits	2
SwissProt Accessions	Q9DBV3	Gene names	Dhx34, Ddx34, Kiaa0134
Domain Architecture
Description	Probable ATP-dependent RNA helicase DHX34 (EC 3.6.1.-) (DEAH box protein 34).

FGD5_HUMAN
θ value	4.03905 (rank : 177)	NC score	0.301161 (rank : 78)
Query Neighborhood Hits	239	Target Neighborhood Hits	235	Shared Neighborhood Hits	67
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

GCC2_MOUSE
θ value	4.03905 (rank : 178)	NC score	0.051884 (rank : 316)
Query Neighborhood Hits	239	Target Neighborhood Hits	1619	Shared Neighborhood Hits	86
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

GOGA2_MOUSE
θ value	4.03905 (rank : 179)	NC score	0.048286 (rank : 362)
Query Neighborhood Hits	239	Target Neighborhood Hits	944	Shared Neighborhood Hits	75
SwissProt Accessions	Q921M4	Gene names	Golga2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130).

K0241_MOUSE
θ value	4.03905 (rank : 180)	NC score	0.013659 (rank : 412)
Query Neighborhood Hits	239	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q80U56	Gene names	Kiaa0241
Domain Architecture	No domain graphic available
Description	Protein KIAA0241.

MYH3_HUMAN
θ value	4.03905 (rank : 181)	NC score	0.043909 (rank : 375)
Query Neighborhood Hits	239	Target Neighborhood Hits	1660	Shared Neighborhood Hits	91
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

OSBL9_HUMAN
θ value	4.03905 (rank : 182)	NC score	0.094587 (rank : 137)
Query Neighborhood Hits	239	Target Neighborhood Hits	138	Shared Neighborhood Hits	51
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

OSBP1_HUMAN
θ value	4.03905 (rank : 183)	NC score	0.054756 (rank : 284)
Query Neighborhood Hits	239	Target Neighborhood Hits	180	Shared Neighborhood Hits	48
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

SPNXA_HUMAN
θ value	4.03905 (rank : 184)	NC score	0.023980 (rank : 400)
Query Neighborhood Hits	239	Target Neighborhood Hits	7	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NS26	Gene names	SPANXA1, SPANXA
Domain Architecture	No domain graphic available
Description	Sperm protein associated with the nucleus on the X chromosome A (Nuclear-associated protein SPAN-Xa) (SPAN-X).

SPNXD_HUMAN
θ value	4.03905 (rank : 185)	NC score	0.024465 (rank : 399)
Query Neighborhood Hits	239	Target Neighborhood Hits	6	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BXN6	Gene names	SPANXD
Domain Architecture	No domain graphic available
Description	Sperm protein associated with the nucleus on the X chromosome D (Nuclear-associated protein SPAN-Xd).

BAI3_MOUSE
θ value	5.27518 (rank : 186)	NC score	0.002657 (rank : 437)
Query Neighborhood Hits	239	Target Neighborhood Hits	250	Shared Neighborhood Hits	4
SwissProt Accessions	Q80ZF8	Gene names	Bai3
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

CENA2_MOUSE
θ value	5.27518 (rank : 187)	NC score	0.029107 (rank : 392)
Query Neighborhood Hits	239	Target Neighborhood Hits	68	Shared Neighborhood Hits	20
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

CND1_MOUSE
θ value	5.27518 (rank : 188)	NC score	0.010413 (rank : 419)
Query Neighborhood Hits	239	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K2Z4, Q8R0F2, Q8R3H0, Q922B7, Q923A3, Q9CS25, Q9CT32	Gene names	Ncapd2, Capd2, Cnap1
Domain Architecture
Description	Condensin complex subunit 1 (Non-SMC condensin I complex subunit D2) (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (mCAP-D2) (XCAP-D2 homolog).

EPN2_MOUSE
θ value	5.27518 (rank : 189)	NC score	0.013298 (rank : 414)
Query Neighborhood Hits	239	Target Neighborhood Hits	111	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CHU3, O70447, Q8BZ85	Gene names	Epn2
Domain Architecture
Description	Epsin-2 (EPS-15-interacting protein 2) (Intersectin-EH-binding protein 2) (Ibp2).

HELZ_HUMAN
θ value	5.27518 (rank : 190)	NC score	0.008205 (rank : 424)
Query Neighborhood Hits	239	Target Neighborhood Hits	198	Shared Neighborhood Hits	7
SwissProt Accessions	P42694	Gene names	HELZ, KIAA0054
Domain Architecture	No domain graphic available
Description	Probable helicase with zinc-finger domain (EC 3.6.1.-).

IRX1_MOUSE
θ value	5.27518 (rank : 191)	NC score	0.007701 (rank : 426)
Query Neighborhood Hits	239	Target Neighborhood Hits	269	Shared Neighborhood Hits	3
SwissProt Accessions	P81068, O55120, Q9JLL6	Gene names	Irx1, Irxa1
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-1 (Iroquois homeobox protein 1) (Homeodomain protein IRXA1).

LAMB1_MOUSE
θ value	5.27518 (rank : 192)	NC score	0.015428 (rank : 407)
Query Neighborhood Hits	239	Target Neighborhood Hits	919	Shared Neighborhood Hits	65
SwissProt Accessions	P02469	Gene names	Lamb1-1, Lamb-1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

LNP_MOUSE
θ value	5.27518 (rank : 193)	NC score	0.012642 (rank : 416)
Query Neighborhood Hits	239	Target Neighborhood Hits	83	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TQ95, Q69ZC5, Q6PAQ1, Q6PEN8	Gene names	Lnp, Kiaa1715, Uln
Domain Architecture	No domain graphic available
Description	Protein lunapark (Protein ulnaless).

MYH1_HUMAN
θ value	5.27518 (rank : 194)	NC score	0.043810 (rank : 376)
Query Neighborhood Hits	239	Target Neighborhood Hits	1478	Shared Neighborhood Hits	88
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH1_MOUSE
θ value	5.27518 (rank : 195)	NC score	0.042628 (rank : 378)
Query Neighborhood Hits	239	Target Neighborhood Hits	1461	Shared Neighborhood Hits	87
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

NEUM_HUMAN
θ value	5.27518 (rank : 196)	NC score	0.013454 (rank : 413)
Query Neighborhood Hits	239	Target Neighborhood Hits	132	Shared Neighborhood Hits	6
SwissProt Accessions	P17677	Gene names	GAP43
Domain Architecture
Description	Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (PP46) (Neural phosphoprotein B-50).

RECK_HUMAN
θ value	5.27518 (rank : 197)	NC score	0.006911 (rank : 429)
Query Neighborhood Hits	239	Target Neighborhood Hits	189	Shared Neighborhood Hits	2
SwissProt Accessions	O95980, Q8WX37	Gene names	RECK
Domain Architecture
Description	Reversion-inducing cysteine-rich protein with Kazal motifs precursor (hRECK) (Suppressor of tumorigenicity 15) (ST15).

REST_HUMAN
θ value	5.27518 (rank : 198)	NC score	0.052516 (rank : 310)
Query Neighborhood Hits	239	Target Neighborhood Hits	1605	Shared Neighborhood Hits	91
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

RHG06_MOUSE
θ value	5.27518 (rank : 199)	NC score	0.037431 (rank : 384)
Query Neighborhood Hits	239	Target Neighborhood Hits	105	Shared Neighborhood Hits	9
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

SCN8A_HUMAN
θ value	5.27518 (rank : 200)	NC score	0.005038 (rank : 433)
Query Neighborhood Hits	239	Target Neighborhood Hits	135	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SRRM1_HUMAN
θ value	5.27518 (rank : 201)	NC score	0.023459 (rank : 402)
Query Neighborhood Hits	239	Target Neighborhood Hits	690	Shared Neighborhood Hits	24
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

TRPM3_HUMAN
θ value	5.27518 (rank : 202)	NC score	0.011752 (rank : 417)
Query Neighborhood Hits	239	Target Neighborhood Hits	121	Shared Neighborhood Hits	8
SwissProt Accessions	Q9HCF6, Q5VW02, Q5VW03, Q5VW04, Q5W5T7, Q86SH0, Q86SH6, Q86UL0, Q86WK1, Q86WK2, Q86WK3, Q86WK4, Q86YZ9, Q86Z00, Q86Z01	Gene names	TRPM3, KIAA1616, LTRPC3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC3) (Melastatin-2) (MLSN2).

UACA_HUMAN
θ value	5.27518 (rank : 203)	NC score	0.039571 (rank : 383)
Query Neighborhood Hits	239	Target Neighborhood Hits	1622	Shared Neighborhood Hits	79
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

ANK3_HUMAN
θ value	6.88961 (rank : 204)	NC score	0.005615 (rank : 432)
Query Neighborhood Hits	239	Target Neighborhood Hits	853	Shared Neighborhood Hits	27
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

BAI3_HUMAN
θ value	6.88961 (rank : 205)	NC score	0.002367 (rank : 438)
Query Neighborhood Hits	239	Target Neighborhood Hits	246	Shared Neighborhood Hits	4
SwissProt Accessions	O60242, O60297	Gene names	BAI3, KIAA0550
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

BICD2_HUMAN
θ value	6.88961 (rank : 206)	NC score	0.052125 (rank : 314)
Query Neighborhood Hits	239	Target Neighborhood Hits	856	Shared Neighborhood Hits	72
SwissProt Accessions	Q8TD16, O75181, Q5TBQ2, Q5TBQ3, Q96LH2, Q9BT84, Q9H561	Gene names	BICD2, KIAA0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

CASP_HUMAN
θ value	6.88961 (rank : 207)	NC score	0.050388 (rank : 347)
Query Neighborhood Hits	239	Target Neighborhood Hits	1131	Shared Neighborhood Hits	76
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CASP_MOUSE
θ value	6.88961 (rank : 208)	NC score	0.050312 (rank : 348)
Query Neighborhood Hits	239	Target Neighborhood Hits	1152	Shared Neighborhood Hits	77
SwissProt Accessions	P70403, Q7TQJ4, Q91WN6	Gene names	Cutl1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CEP55_MOUSE
θ value	6.88961 (rank : 209)	NC score	0.053055 (rank : 301)
Query Neighborhood Hits	239	Target Neighborhood Hits	693	Shared Neighborhood Hits	70
SwissProt Accessions	Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8	Gene names	Cep55
Domain Architecture	No domain graphic available
Description	Centrosome protein 55.

CUTL1_HUMAN
θ value	6.88961 (rank : 210)	NC score	0.045387 (rank : 373)
Query Neighborhood Hits	239	Target Neighborhood Hits	1574	Shared Neighborhood Hits	83
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

CUTL1_MOUSE
θ value	6.88961 (rank : 211)	NC score	0.045967 (rank : 369)
Query Neighborhood Hits	239	Target Neighborhood Hits	1620	Shared Neighborhood Hits	80
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

FBX3_MOUSE
θ value	6.88961 (rank : 212)	NC score	0.009467 (rank : 423)
Query Neighborhood Hits	239	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	Q9DC63, Q3TKB0	Gene names	Fbxo3, Fba, Fbx3
Domain Architecture
Description	F-box only protein 3.

FES_HUMAN
θ value	6.88961 (rank : 213)	NC score	-0.003271 (rank : 443)
Query Neighborhood Hits	239	Target Neighborhood Hits	978	Shared Neighborhood Hits	20
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

LIN1_HUMAN
θ value	6.88961 (rank : 214)	NC score	0.027859 (rank : 395)
Query Neighborhood Hits	239	Target Neighborhood Hits	187	Shared Neighborhood Hits	28
SwissProt Accessions	P08547	Gene names
Domain Architecture	No domain graphic available
Description	LINE-1 reverse transcriptase homolog.

PKHB1_MOUSE
θ value	6.88961 (rank : 215)	NC score	0.049915 (rank : 358)
Query Neighborhood Hits	239	Target Neighborhood Hits	47	Shared Neighborhood Hits	24
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

SYCP1_HUMAN
θ value	6.88961 (rank : 216)	NC score	0.048071 (rank : 364)
Query Neighborhood Hits	239	Target Neighborhood Hits	1313	Shared Neighborhood Hits	83
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

THAP4_MOUSE
θ value	6.88961 (rank : 217)	NC score	0.014095 (rank : 410)
Query Neighborhood Hits	239	Target Neighborhood Hits	130	Shared Neighborhood Hits	11
SwissProt Accessions	Q6P3Z3, Q3US28, Q6NZN6, Q6PEN6, Q91WR2, Q9CVE5, Q9CVG3	Gene names	Thap4
Domain Architecture	No domain graphic available
Description	THAP domain-containing protein 4.

TPR_HUMAN
θ value	6.88961 (rank : 218)	NC score	0.053017 (rank : 302)
Query Neighborhood Hits	239	Target Neighborhood Hits	1921	Shared Neighborhood Hits	98
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

UBDC1_HUMAN
θ value	6.88961 (rank : 219)	NC score	0.009730 (rank : 422)
Query Neighborhood Hits	239	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BSL1, O75500, Q9UMW7	Gene names	UBADC1, GBDR1, KPC2
Domain Architecture	No domain graphic available
Description	Ubiquitin-associated domain-containing protein 1 (E3 ubiquitin-protein ligase subunit KPC2) (Kip1 ubiquitination-promoting complex protein 2) (Glialblastoma cell differentiation-related protein 1).

BPAEA_MOUSE
θ value	8.99809 (rank : 220)	NC score	0.049098 (rank : 361)
Query Neighborhood Hits	239	Target Neighborhood Hits	1480	Shared Neighborhood Hits	84
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

CENPE_HUMAN
θ value	8.99809 (rank : 221)	NC score	0.047051 (rank : 365)
Query Neighborhood Hits	239	Target Neighborhood Hits	2060	Shared Neighborhood Hits	102
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

CENPQ_MOUSE
θ value	8.99809 (rank : 222)	NC score	0.023572 (rank : 401)
Query Neighborhood Hits	239	Target Neighborhood Hits	160	Shared Neighborhood Hits	27
SwissProt Accessions	Q9CPQ5, Q8C2G4, Q8VEF8, Q9CX70	Gene names	Cenpq
Domain Architecture	No domain graphic available
Description	Centromere protein Q (CENP-Q).

HMCN1_HUMAN
θ value	8.99809 (rank : 223)	NC score	-0.004174 (rank : 445)
Query Neighborhood Hits	239	Target Neighborhood Hits	983	Shared Neighborhood Hits	8
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

HMMR_MOUSE
θ value	8.99809 (rank : 224)	NC score	0.054562 (rank : 287)
Query Neighborhood Hits	239	Target Neighborhood Hits	1178	Shared Neighborhood Hits	82
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

HOOK3_MOUSE
θ value	8.99809 (rank : 225)	NC score	0.050217 (rank : 353)
Query Neighborhood Hits	239	Target Neighborhood Hits	1007	Shared Neighborhood Hits	81
SwissProt Accessions	Q8BUK6, Q8BV48, Q8BW57, Q8BY41	Gene names	Hook3
Domain Architecture
Description	Hook homolog 3.

KIF5C_MOUSE
θ value	8.99809 (rank : 226)	NC score	0.036425 (rank : 386)
Query Neighborhood Hits	239	Target Neighborhood Hits	1040	Shared Neighborhood Hits	79
SwissProt Accessions	P28738, Q9Z2F8	Gene names	Kif5c, Nkhc2
Domain Architecture
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

MCF2_HUMAN
θ value	8.99809 (rank : 227)	NC score	0.306079 (rank : 76)
Query Neighborhood Hits	239	Target Neighborhood Hits	166	Shared Neighborhood Hits	69
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MYH10_HUMAN
θ value	8.99809 (rank : 228)	NC score	0.041306 (rank : 381)
Query Neighborhood Hits	239	Target Neighborhood Hits	1620	Shared Neighborhood Hits	85
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

NIPBL_HUMAN
θ value	8.99809 (rank : 229)	NC score	0.007931 (rank : 425)
Query Neighborhood Hits	239	Target Neighborhood Hits	1311	Shared Neighborhood Hits	44
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

NUF2_HUMAN
θ value	8.99809 (rank : 230)	NC score	0.043963 (rank : 374)
Query Neighborhood Hits	239	Target Neighborhood Hits	661	Shared Neighborhood Hits	63
SwissProt Accessions	Q9BZD4, Q8WU69, Q96HJ4, Q96Q78	Gene names	CDCA1, NUF2, NUF2R
Domain Architecture	No domain graphic available
Description	Kinetochore protein Nuf2 (hNuf2) (hNuf2R) (hsNuf2) (Cell division cycle-associated protein 1).

PELP1_MOUSE
θ value	8.99809 (rank : 231)	NC score	0.011503 (rank : 418)
Query Neighborhood Hits	239	Target Neighborhood Hits	709	Shared Neighborhood Hits	24
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

PKHA3_HUMAN
θ value	8.99809 (rank : 232)	NC score	0.069252 (rank : 198)
Query Neighborhood Hits	239	Target Neighborhood Hits	66	Shared Neighborhood Hits	33
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

RNF34_MOUSE
θ value	8.99809 (rank : 233)	NC score	0.006915 (rank : 428)
Query Neighborhood Hits	239	Target Neighborhood Hits	160	Shared Neighborhood Hits	6
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

RPGR1_HUMAN
θ value	8.99809 (rank : 234)	NC score	0.045450 (rank : 371)
Query Neighborhood Hits	239	Target Neighborhood Hits	578	Shared Neighborhood Hits	68
SwissProt Accessions	Q96KN7, Q7Z2W6, Q8IXV5, Q96QA8, Q9HB94, Q9HB95, Q9HBK6, Q9NR40	Gene names	RPGRIP1
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

SCN8A_MOUSE
θ value	8.99809 (rank : 235)	NC score	0.002808 (rank : 436)
Query Neighborhood Hits	239	Target Neighborhood Hits	136	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SNX8_HUMAN
θ value	8.99809 (rank : 236)	NC score	0.010181 (rank : 421)
Query Neighborhood Hits	239	Target Neighborhood Hits	66	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y5X2, Q96I67	Gene names	SNX8
Domain Architecture
Description	Sorting nexin-8.

TBX4_HUMAN
θ value	8.99809 (rank : 237)	NC score	0.001661 (rank : 440)
Query Neighborhood Hits	239	Target Neighborhood Hits	70	Shared Neighborhood Hits	4
SwissProt Accessions	P57082	Gene names	TBX4
Domain Architecture
Description	T-box transcription factor TBX4 (T-box protein 4).

TGON2_HUMAN
θ value	8.99809 (rank : 238)	NC score	0.006977 (rank : 427)
Query Neighborhood Hits	239	Target Neighborhood Hits	1037	Shared Neighborhood Hits	24
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

TXLNB_MOUSE
θ value	8.99809 (rank : 239)	NC score	0.030076 (rank : 391)
Query Neighborhood Hits	239	Target Neighborhood Hits	640	Shared Neighborhood Hits	59
SwissProt Accessions	Q8VBT1, Q3UVB8, Q8BUK2	Gene names	Txlnb, Mdp77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77).

ABI1_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.072148 (rank : 185)
Query Neighborhood Hits	239	Target Neighborhood Hits	257	Shared Neighborhood Hits	24
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 241)	NC score	0.075338 (rank : 171)
Query Neighborhood Hits	239	Target Neighborhood Hits	246	Shared Neighborhood Hits	22
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.078555 (rank : 162)
Query Neighborhood Hits	239	Target Neighborhood Hits	350	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 243)	NC score	0.078905 (rank : 159)
Query Neighborhood Hits	239	Target Neighborhood Hits	266	Shared Neighborhood Hits	23
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.069907 (rank : 195)
Query Neighborhood Hits	239	Target Neighborhood Hits	227	Shared Neighborhood Hits	22
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 245)	NC score	0.067178 (rank : 208)
Query Neighborhood Hits	239	Target Neighborhood Hits	227	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AHI1_HUMAN
θ value	θ > 10 (rank : 246)	NC score	0.055518 (rank : 282)
Query Neighborhood Hits	239	Target Neighborhood Hits	537	Shared Neighborhood Hits	28
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 247)	NC score	0.054043 (rank : 294)
Query Neighborhood Hits	239	Target Neighborhood Hits	496	Shared Neighborhood Hits	26
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ALS2_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.050288 (rank : 350)
Query Neighborhood Hits	239	Target Neighborhood Hits	111	Shared Neighborhood Hits	22
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

ARHG1_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.305670 (rank : 77)
Query Neighborhood Hits	239	Target Neighborhood Hits	176	Shared Neighborhood Hits	52
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 250)	NC score	0.299574 (rank : 79)
Query Neighborhood Hits	239	Target Neighborhood Hits	266	Shared Neighborhood Hits	53
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.275466 (rank : 89)
Query Neighborhood Hits	239	Target Neighborhood Hits	142	Shared Neighborhood Hits	51
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.286911 (rank : 83)
Query Neighborhood Hits	239	Target Neighborhood Hits	120	Shared Neighborhood Hits	54
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG4_MOUSE
θ value	θ > 10 (rank : 253)	NC score	0.421221 (rank : 50)
Query Neighborhood Hits	239	Target Neighborhood Hits	185	Shared Neighborhood Hits	58
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG9_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.400491 (rank : 51)
Query Neighborhood Hits	239	Target Neighborhood Hits	235	Shared Neighborhood Hits	59
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 255)	NC score	0.400016 (rank : 52)
Query Neighborhood Hits	239	Target Neighborhood Hits	234	Shared Neighborhood Hits	59
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHGC_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.279874 (rank : 86)
Query Neighborhood Hits	239	Target Neighborhood Hits	351	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 257)	NC score	0.283226 (rank : 84)
Query Neighborhood Hits	239	Target Neighborhood Hits	344	Shared Neighborhood Hits	69
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

BI2L1_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.069590 (rank : 196)
Query Neighborhood Hits	239	Target Neighborhood Hits	156	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 259)	NC score	0.059678 (rank : 252)
Query Neighborhood Hits	239	Target Neighborhood Hits	197	Shared Neighborhood Hits	33
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BIG1_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.054737 (rank : 285)
Query Neighborhood Hits	239	Target Neighborhood Hits	76	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

BIG2_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.056023 (rank : 278)
Query Neighborhood Hits	239	Target Neighborhood Hits	66	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

CCD13_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.052629 (rank : 309)
Query Neighborhood Hits	239	Target Neighborhood Hits	721	Shared Neighborhood Hits	68
SwissProt Accessions	Q8IYE1	Gene names	CCDC13
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 13.

CCD21_MOUSE
θ value	θ > 10 (rank : 263)	NC score	0.050602 (rank : 337)
Query Neighborhood Hits	239	Target Neighborhood Hits	1135	Shared Neighborhood Hits	84
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CCD41_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.051528 (rank : 322)
Query Neighborhood Hits	239	Target Neighborhood Hits	1139	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

CCD46_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.051718 (rank : 319)
Query Neighborhood Hits	239	Target Neighborhood Hits	1430	Shared Neighborhood Hits	84
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

CCD46_MOUSE
θ value	θ > 10 (rank : 266)	NC score	0.052102 (rank : 315)
Query Neighborhood Hits	239	Target Neighborhood Hits	1405	Shared Neighborhood Hits	87
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

CCD96_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.061876 (rank : 242)
Query Neighborhood Hits	239	Target Neighborhood Hits	704	Shared Neighborhood Hits	70
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

CD2AP_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.104104 (rank : 127)
Query Neighborhood Hits	239	Target Neighborhood Hits	315	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.106112 (rank : 125)
Query Neighborhood Hits	239	Target Neighborhood Hits	336	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CE152_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.050455 (rank : 341)
Query Neighborhood Hits	239	Target Neighborhood Hits	976	Shared Neighborhood Hits	76
SwissProt Accessions	O94986, Q6NTA0	Gene names	CEP152, KIAA0912
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 152 kDa (Cep152 protein).

CE290_HUMAN
θ value	θ > 10 (rank : 271)	NC score	0.051812 (rank : 318)
Query Neighborhood Hits	239	Target Neighborhood Hits	1553	Shared Neighborhood Hits	86
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

CEP63_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.054587 (rank : 286)
Query Neighborhood Hits	239	Target Neighborhood Hits	1005	Shared Neighborhood Hits	75
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

CHIN_HUMAN
θ value	θ > 10 (rank : 273)	NC score	0.058411 (rank : 259)
Query Neighborhood Hits	239	Target Neighborhood Hits	227	Shared Neighborhood Hits	19
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 274)	NC score	0.058533 (rank : 258)
Query Neighborhood Hits	239	Target Neighborhood Hits	229	Shared Neighborhood Hits	19
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 275)	NC score	0.055204 (rank : 283)
Query Neighborhood Hits	239	Target Neighborhood Hits	220	Shared Neighborhood Hits	19
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_MOUSE
θ value	θ > 10 (rank : 276)	NC score	0.056093 (rank : 277)
Query Neighborhood Hits	239	Target Neighborhood Hits	130	Shared Neighborhood Hits	17
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CI093_HUMAN
θ value	θ > 10 (rank : 277)	NC score	0.051017 (rank : 332)
Query Neighborhood Hits	239	Target Neighborhood Hits	1088	Shared Neighborhood Hits	79
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

CNKR1_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.106620 (rank : 124)
Query Neighborhood Hits	239	Target Neighborhood Hits	154	Shared Neighborhood Hits	37
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CP135_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.050475 (rank : 340)
Query Neighborhood Hits	239	Target Neighborhood Hits	1278	Shared Neighborhood Hits	82
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

CP250_MOUSE
θ value	θ > 10 (rank : 280)	NC score	0.056545 (rank : 274)
Query Neighborhood Hits	239	Target Neighborhood Hits	1583	Shared Neighborhood Hits	90
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

CRKL_HUMAN
θ value	θ > 10 (rank : 281)	NC score	0.071546 (rank : 189)
Query Neighborhood Hits	239	Target Neighborhood Hits	313	Shared Neighborhood Hits	21
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 282)	NC score	0.070361 (rank : 193)
Query Neighborhood Hits	239	Target Neighborhood Hits	307	Shared Neighborhood Hits	21
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 283)	NC score	0.066223 (rank : 216)
Query Neighborhood Hits	239	Target Neighborhood Hits	308	Shared Neighborhood Hits	21
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 284)	NC score	0.068055 (rank : 203)
Query Neighborhood Hits	239	Target Neighborhood Hits	314	Shared Neighborhood Hits	22
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CT152_HUMAN
θ value	θ > 10 (rank : 285)	NC score	0.070828 (rank : 191)
Query Neighborhood Hits	239	Target Neighborhood Hits	30	Shared Neighborhood Hits	6
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

CT152_MOUSE
θ value	θ > 10 (rank : 286)	NC score	0.056553 (rank : 273)
Query Neighborhood Hits	239	Target Neighborhood Hits	38	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

CYLN2_HUMAN
θ value	θ > 10 (rank : 287)	NC score	0.051081 (rank : 331)
Query Neighborhood Hits	239	Target Neighborhood Hits	1004	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UDT6, O14527, O43611	Gene names	CYLN2, KIAA0291, WBSCR4, WSCR4
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115) (Williams-Beuren syndrome chromosome region 4 protein).

DBNL_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.059548 (rank : 254)
Query Neighborhood Hits	239	Target Neighborhood Hits	244	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.055875 (rank : 279)
Query Neighborhood Hits	239	Target Neighborhood Hits	306	Shared Neighborhood Hits	24
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

EEA1_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.077984 (rank : 164)
Query Neighborhood Hits	239	Target Neighborhood Hits	1796	Shared Neighborhood Hits	104
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

EP15R_HUMAN
θ value	θ > 10 (rank : 291)	NC score	0.065780 (rank : 220)
Query Neighborhood Hits	239	Target Neighborhood Hits	1083	Shared Neighborhood Hits	82
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

EP15R_MOUSE
θ value	θ > 10 (rank : 292)	NC score	0.067597 (rank : 206)
Query Neighborhood Hits	239	Target Neighborhood Hits	1135	Shared Neighborhood Hits	82
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

EP15_HUMAN
θ value	θ > 10 (rank : 293)	NC score	0.066424 (rank : 214)
Query Neighborhood Hits	239	Target Neighborhood Hits	1021	Shared Neighborhood Hits	79
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP15_MOUSE
θ value	θ > 10 (rank : 294)	NC score	0.058166 (rank : 262)
Query Neighborhood Hits	239	Target Neighborhood Hits	820	Shared Neighborhood Hits	66
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

FARP2_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.307150 (rank : 75)
Query Neighborhood Hits	239	Target Neighborhood Hits	240	Shared Neighborhood Hits	84
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FBX8_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.051116 (rank : 329)
Query Neighborhood Hits	239	Target Neighborhood Hits	44	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NRD0, Q6UWN4, Q9NRP5, Q9UKC4	Gene names	FBXO8, FBS, FBX8
Domain Architecture
Description	F-box only protein 8 (F-box/SEC7 protein FBS).

FBX8_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.051286 (rank : 327)
Query Neighborhood Hits	239	Target Neighborhood Hits	45	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QZN3	Gene names	Fbxo8, Fbx8
Domain Architecture
Description	F-box only protein 8.

FLIP1_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.051181 (rank : 328)
Query Neighborhood Hits	239	Target Neighborhood Hits	1405	Shared Neighborhood Hits	89
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

FNBP2_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.067168 (rank : 209)
Query Neighborhood Hits	239	Target Neighborhood Hits	432	Shared Neighborhood Hits	60
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

FYCO1_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.069241 (rank : 200)
Query Neighborhood Hits	239	Target Neighborhood Hits	1149	Shared Neighborhood Hits	89
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

FYCO1_MOUSE
θ value	θ > 10 (rank : 301)	NC score	0.067842 (rank : 204)
Query Neighborhood Hits	239	Target Neighborhood Hits	1059	Shared Neighborhood Hits	88
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

FYV1_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.070219 (rank : 194)
Query Neighborhood Hits	239	Target Neighborhood Hits	217	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	θ > 10 (rank : 303)	NC score	0.069243 (rank : 199)
Query Neighborhood Hits	239	Target Neighborhood Hits	191	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

GBF1_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.056993 (rank : 268)
Query Neighborhood Hits	239	Target Neighborhood Hits	142	Shared Neighborhood Hits	13
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

GOGA5_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.050859 (rank : 333)
Query Neighborhood Hits	239	Target Neighborhood Hits	1168	Shared Neighborhood Hits	85
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

GRAP2_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.065923 (rank : 218)
Query Neighborhood Hits	239	Target Neighborhood Hits	304	Shared Neighborhood Hits	19
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.066065 (rank : 217)
Query Neighborhood Hits	239	Target Neighborhood Hits	297	Shared Neighborhood Hits	19
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.088312 (rank : 144)
Query Neighborhood Hits	239	Target Neighborhood Hits	307	Shared Neighborhood Hits	22
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.088216 (rank : 145)
Query Neighborhood Hits	239	Target Neighborhood Hits	309	Shared Neighborhood Hits	22
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.078729 (rank : 160)
Query Neighborhood Hits	239	Target Neighborhood Hits	310	Shared Neighborhood Hits	21
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.078687 (rank : 161)
Query Neighborhood Hits	239	Target Neighborhood Hits	312	Shared Neighborhood Hits	21
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

HCLS1_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.072935 (rank : 181)
Query Neighborhood Hits	239	Target Neighborhood Hits	358	Shared Neighborhood Hits	24
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 313)	NC score	0.071795 (rank : 188)
Query Neighborhood Hits	239	Target Neighborhood Hits	329	Shared Neighborhood Hits	24
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HGS_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.073477 (rank : 179)
Query Neighborhood Hits	239	Target Neighborhood Hits	517	Shared Neighborhood Hits	35
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	θ > 10 (rank : 315)	NC score	0.073781 (rank : 177)
Query Neighborhood Hits	239	Target Neighborhood Hits	589	Shared Neighborhood Hits	40
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

IFT74_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.050303 (rank : 349)
Query Neighborhood Hits	239	Target Neighborhood Hits	949	Shared Neighborhood Hits	75
SwissProt Accessions	Q96LB3, Q6PGQ8, Q9H643, Q9H8G7	Gene names	IFT74, CCDC2, CMG1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

IFT81_MOUSE
θ value	θ > 10 (rank : 317)	NC score	0.051388 (rank : 324)
Query Neighborhood Hits	239	Target Neighborhood Hits	959	Shared Neighborhood Hits	72
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

IQEC1_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.050184 (rank : 354)
Query Neighborhood Hits	239	Target Neighborhood Hits	76	Shared Neighborhood Hits	15
SwissProt Accessions	Q6DN90, O94863, Q96D85	Gene names	IQSEC1, ARFGEP100, BRAG2, KIAA0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein).

IQEC2_HUMAN
θ value	θ > 10 (rank : 319)	NC score	0.050232 (rank : 351)
Query Neighborhood Hits	239	Target Neighborhood Hits	403	Shared Neighborhood Hits	29
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC3_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.061602 (rank : 243)
Query Neighborhood Hits	239	Target Neighborhood Hits	125	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

IQEC3_MOUSE
θ value	θ > 10 (rank : 321)	NC score	0.058348 (rank : 261)
Query Neighborhood Hits	239	Target Neighborhood Hits	274	Shared Neighborhood Hits	23
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

JIP3_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.053377 (rank : 299)
Query Neighborhood Hits	239	Target Neighborhood Hits	1039	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

LASP1_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.058536 (rank : 257)
Query Neighborhood Hits	239	Target Neighborhood Hits	293	Shared Neighborhood Hits	23
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	θ > 10 (rank : 324)	NC score	0.056965 (rank : 269)
Query Neighborhood Hits	239	Target Neighborhood Hits	297	Shared Neighborhood Hits	23
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LBC_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.277328 (rank : 87)
Query Neighborhood Hits	239	Target Neighborhood Hits	90	Shared Neighborhood Hits	47
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

LMO7_HUMAN
θ value	θ > 10 (rank : 326)	NC score	0.058109 (rank : 263)
Query Neighborhood Hits	239	Target Neighborhood Hits	507	Shared Neighborhood Hits	52
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

MCF2L_MOUSE
θ value	θ > 10 (rank : 327)	NC score	0.282582 (rank : 85)
Query Neighborhood Hits	239	Target Neighborhood Hits	255	Shared Neighborhood Hits	73
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MD1L1_MOUSE
θ value	θ > 10 (rank : 328)	NC score	0.052828 (rank : 305)
Query Neighborhood Hits	239	Target Neighborhood Hits	1001	Shared Neighborhood Hits	76
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

MRIP_HUMAN
θ value	θ > 10 (rank : 329)	NC score	0.052813 (rank : 306)
Query Neighborhood Hits	239	Target Neighborhood Hits	578	Shared Neighborhood Hits	97
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

MRIP_MOUSE
θ value	θ > 10 (rank : 330)	NC score	0.050552 (rank : 338)
Query Neighborhood Hits	239	Target Neighborhood Hits	569	Shared Neighborhood Hits	95
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

NCF1_HUMAN
θ value	θ > 10 (rank : 331)	NC score	0.100700 (rank : 128)
Query Neighborhood Hits	239	Target Neighborhood Hits	198	Shared Neighborhood Hits	22
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 332)	NC score	0.097324 (rank : 133)
Query Neighborhood Hits	239	Target Neighborhood Hits	198	Shared Neighborhood Hits	22
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 333)	NC score	0.097607 (rank : 132)
Query Neighborhood Hits	239	Target Neighborhood Hits	229	Shared Neighborhood Hits	23
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 334)	NC score	0.073274 (rank : 180)
Query Neighborhood Hits	239	Target Neighborhood Hits	161	Shared Neighborhood Hits	17
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 335)	NC score	0.073936 (rank : 175)
Query Neighborhood Hits	239	Target Neighborhood Hits	177	Shared Neighborhood Hits	19
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 336)	NC score	0.100324 (rank : 129)
Query Neighborhood Hits	239	Target Neighborhood Hits	312	Shared Neighborhood Hits	26
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 337)	NC score	0.095987 (rank : 135)
Query Neighborhood Hits	239	Target Neighborhood Hits	310	Shared Neighborhood Hits	26
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NEBL_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.067252 (rank : 207)
Query Neighborhood Hits	239	Target Neighborhood Hits	457	Shared Neighborhood Hits	53
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NEBU_HUMAN
θ value	θ > 10 (rank : 339)	NC score	0.050432 (rank : 343)
Query Neighborhood Hits	239	Target Neighborhood Hits	420	Shared Neighborhood Hits	37
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

NEMO_HUMAN
θ value	θ > 10 (rank : 340)	NC score	0.050011 (rank : 357)
Query Neighborhood Hits	239	Target Neighborhood Hits	820	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y6K9	Gene names	IKBKG, FIP3, NEMO
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (FIP-3).

NOXO1_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.051087 (rank : 330)
Query Neighborhood Hits	239	Target Neighborhood Hits	100	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 342)	NC score	0.065501 (rank : 221)
Query Neighborhood Hits	239	Target Neighborhood Hits	114	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_MOUSE
θ value	θ > 10 (rank : 343)	NC score	0.052708 (rank : 308)
Query Neighborhood Hits	239	Target Neighborhood Hits	267	Shared Neighborhood Hits	30
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OPTN_MOUSE
θ value	θ > 10 (rank : 344)	NC score	0.050232 (rank : 352)
Query Neighborhood Hits	239	Target Neighborhood Hits	1120	Shared Neighborhood Hits	79
SwissProt Accessions	Q8K3K8	Gene names	Optn
Domain Architecture	No domain graphic available
Description	Optineurin.

OSTF1_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.060527 (rank : 248)
Query Neighborhood Hits	239	Target Neighborhood Hits	466	Shared Neighborhood Hits	25
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 346)	NC score	0.059825 (rank : 251)
Query Neighborhood Hits	239	Target Neighborhood Hits	467	Shared Neighborhood Hits	25
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

P85A_HUMAN
θ value	θ > 10 (rank : 347)	NC score	0.064866 (rank : 224)
Query Neighborhood Hits	239	Target Neighborhood Hits	479	Shared Neighborhood Hits	61
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 348)	NC score	0.060247 (rank : 250)
Query Neighborhood Hits	239	Target Neighborhood Hits	435	Shared Neighborhood Hits	56
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 349)	NC score	0.060470 (rank : 249)
Query Neighborhood Hits	239	Target Neighborhood Hits	543	Shared Neighborhood Hits	62
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 350)	NC score	0.059654 (rank : 253)
Query Neighborhood Hits	239	Target Neighborhood Hits	519	Shared Neighborhood Hits	63
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PACN2_HUMAN
θ value	θ > 10 (rank : 351)	NC score	0.051617 (rank : 320)
Query Neighborhood Hits	239	Target Neighborhood Hits	339	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 352)	NC score	0.052230 (rank : 313)
Query Neighborhood Hits	239	Target Neighborhood Hits	382	Shared Neighborhood Hits	43
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 353)	NC score	0.054351 (rank : 291)
Query Neighborhood Hits	239	Target Neighborhood Hits	385	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 354)	NC score	0.056593 (rank : 272)
Query Neighborhood Hits	239	Target Neighborhood Hits	380	Shared Neighborhood Hits	45
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PCNT_HUMAN
θ value	θ > 10 (rank : 355)	NC score	0.054543 (rank : 288)
Query Neighborhood Hits	239	Target Neighborhood Hits	1551	Shared Neighborhood Hits	93
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

PEX13_HUMAN
θ value	θ > 10 (rank : 356)	NC score	0.051409 (rank : 323)
Query Neighborhood Hits	239	Target Neighborhood Hits	128	Shared Neighborhood Hits	16
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 357)	NC score	0.052414 (rank : 311)
Query Neighborhood Hits	239	Target Neighborhood Hits	126	Shared Neighborhood Hits	16
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PHLB1_HUMAN
θ value	θ > 10 (rank : 358)	NC score	0.052370 (rank : 312)
Query Neighborhood Hits	239	Target Neighborhood Hits	1038	Shared Neighborhood Hits	96
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PHLB2_HUMAN
θ value	θ > 10 (rank : 359)	NC score	0.058364 (rank : 260)
Query Neighborhood Hits	239	Target Neighborhood Hits	964	Shared Neighborhood Hits	101
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PHLB2_MOUSE
θ value	θ > 10 (rank : 360)	NC score	0.060728 (rank : 247)
Query Neighborhood Hits	239	Target Neighborhood Hits	1016	Shared Neighborhood Hits	102
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PKHA1_HUMAN
θ value	θ > 10 (rank : 361)	NC score	0.091539 (rank : 142)
Query Neighborhood Hits	239	Target Neighborhood Hits	127	Shared Neighborhood Hits	44
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	θ > 10 (rank : 362)	NC score	0.090051 (rank : 143)
Query Neighborhood Hits	239	Target Neighborhood Hits	120	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_HUMAN
θ value	θ > 10 (rank : 363)	NC score	0.086288 (rank : 148)
Query Neighborhood Hits	239	Target Neighborhood Hits	119	Shared Neighborhood Hits	49
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHA2_MOUSE
θ value	θ > 10 (rank : 364)	NC score	0.093294 (rank : 139)
Query Neighborhood Hits	239	Target Neighborhood Hits	116	Shared Neighborhood Hits	52
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHF1_HUMAN
θ value	θ > 10 (rank : 365)	NC score	0.137741 (rank : 114)
Query Neighborhood Hits	239	Target Neighborhood Hits	76	Shared Neighborhood Hits	21
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
θ value	θ > 10 (rank : 366)	NC score	0.135941 (rank : 117)
Query Neighborhood Hits	239	Target Neighborhood Hits	80	Shared Neighborhood Hits	20
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF2_HUMAN
θ value	θ > 10 (rank : 367)	NC score	0.148097 (rank : 105)
Query Neighborhood Hits	239	Target Neighborhood Hits	75	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	θ > 10 (rank : 368)	NC score	0.148639 (rank : 104)
Query Neighborhood Hits	239	Target Neighborhood Hits	77	Shared Neighborhood Hits	25
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHG1_HUMAN
θ value	θ > 10 (rank : 369)	NC score	0.398111 (rank : 54)
Query Neighborhood Hits	239	Target Neighborhood Hits	174	Shared Neighborhood Hits	64
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PKHG4_HUMAN
θ value	θ > 10 (rank : 370)	NC score	0.215269 (rank : 90)
Query Neighborhood Hits	239	Target Neighborhood Hits	200	Shared Neighborhood Hits	52
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

PLCG1_HUMAN
θ value	θ > 10 (rank : 371)	NC score	0.076175 (rank : 169)
Query Neighborhood Hits	239	Target Neighborhood Hits	293	Shared Neighborhood Hits	27
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 372)	NC score	0.077817 (rank : 165)
Query Neighborhood Hits	239	Target Neighborhood Hits	314	Shared Neighborhood Hits	27
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 373)	NC score	0.062580 (rank : 234)
Query Neighborhood Hits	239	Target Neighborhood Hits	280	Shared Neighborhood Hits	20
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP1_HUMAN
θ value	θ > 10 (rank : 374)	NC score	0.077304 (rank : 166)
Query Neighborhood Hits	239	Target Neighborhood Hits	389	Shared Neighborhood Hits	52
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 375)	NC score	0.071276 (rank : 190)
Query Neighborhood Hits	239	Target Neighborhood Hits	377	Shared Neighborhood Hits	41
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PSD3_HUMAN
θ value	θ > 10 (rank : 376)	NC score	0.068885 (rank : 201)
Query Neighborhood Hits	239	Target Neighborhood Hits	75	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

PSD4_HUMAN
θ value	θ > 10 (rank : 377)	NC score	0.059447 (rank : 255)
Query Neighborhood Hits	239	Target Neighborhood Hits	178	Shared Neighborhood Hits	22
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

PSD4_MOUSE
θ value	θ > 10 (rank : 378)	NC score	0.061900 (rank : 241)
Query Neighborhood Hits	239	Target Neighborhood Hits	78	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

RABE1_HUMAN
θ value	θ > 10 (rank : 379)	NC score	0.050103 (rank : 355)
Query Neighborhood Hits	239	Target Neighborhood Hits	1104	Shared Neighborhood Hits	73
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

RAD50_HUMAN
θ value	θ > 10 (rank : 380)	NC score	0.050404 (rank : 344)
Query Neighborhood Hits	239	Target Neighborhood Hits	1317	Shared Neighborhood Hits	86
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

RAD50_MOUSE
θ value	θ > 10 (rank : 381)	NC score	0.050511 (rank : 339)
Query Neighborhood Hits	239	Target Neighborhood Hits	1366	Shared Neighborhood Hits	85
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

RBNS5_HUMAN
θ value	θ > 10 (rank : 382)	NC score	0.074137 (rank : 174)
Query Neighborhood Hits	239	Target Neighborhood Hits	242	Shared Neighborhood Hits	29
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	θ > 10 (rank : 383)	NC score	0.073879 (rank : 176)
Query Neighborhood Hits	239	Target Neighborhood Hits	266	Shared Neighborhood Hits	36
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

REPS1_HUMAN
θ value	θ > 10 (rank : 384)	NC score	0.050622 (rank : 336)
Query Neighborhood Hits	239	Target Neighborhood Hits	205	Shared Neighborhood Hits	14
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS1_MOUSE
θ value	θ > 10 (rank : 385)	NC score	0.057842 (rank : 264)
Query Neighborhood Hits	239	Target Neighborhood Hits	204	Shared Neighborhood Hits	21
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS2_HUMAN
θ value	θ > 10 (rank : 386)	NC score	0.054220 (rank : 292)
Query Neighborhood Hits	239	Target Neighborhood Hits	131	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_MOUSE
θ value	θ > 10 (rank : 387)	NC score	0.054010 (rank : 295)
Query Neighborhood Hits	239	Target Neighborhood Hits	102	Shared Neighborhood Hits	7
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

RFIP3_HUMAN
θ value	θ > 10 (rank : 388)	NC score	0.053406 (rank : 298)
Query Neighborhood Hits	239	Target Neighborhood Hits	1055	Shared Neighborhood Hits	84
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

RHG04_HUMAN
θ value	θ > 10 (rank : 389)	NC score	0.072707 (rank : 183)
Query Neighborhood Hits	239	Target Neighborhood Hits	307	Shared Neighborhood Hits	32
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RHG26_HUMAN
θ value	θ > 10 (rank : 390)	NC score	0.067789 (rank : 205)
Query Neighborhood Hits	239	Target Neighborhood Hits	281	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RIMB1_HUMAN
θ value	θ > 10 (rank : 391)	NC score	0.051866 (rank : 317)
Query Neighborhood Hits	239	Target Neighborhood Hits	1479	Shared Neighborhood Hits	86
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB1_MOUSE
θ value	θ > 10 (rank : 392)	NC score	0.056273 (rank : 275)
Query Neighborhood Hits	239	Target Neighborhood Hits	1376	Shared Neighborhood Hits	87
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RUFY1_HUMAN
θ value	θ > 10 (rank : 393)	NC score	0.076556 (rank : 167)
Query Neighborhood Hits	239	Target Neighborhood Hits	848	Shared Neighborhood Hits	83
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

RUFY1_MOUSE
θ value	θ > 10 (rank : 394)	NC score	0.073557 (rank : 178)
Query Neighborhood Hits	239	Target Neighborhood Hits	765	Shared Neighborhood Hits	76
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY2_HUMAN
θ value	θ > 10 (rank : 395)	NC score	0.079520 (rank : 157)
Query Neighborhood Hits	239	Target Neighborhood Hits	1208	Shared Neighborhood Hits	90
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

RUFY2_MOUSE
θ value	θ > 10 (rank : 396)	NC score	0.082818 (rank : 155)
Query Neighborhood Hits	239	Target Neighborhood Hits	820	Shared Neighborhood Hits	83
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

SAS6_MOUSE
θ value	θ > 10 (rank : 397)	NC score	0.052941 (rank : 304)
Query Neighborhood Hits	239	Target Neighborhood Hits	931	Shared Neighborhood Hits	76
SwissProt Accessions	Q80UK7, Q9CYT4	Gene names	Sass6, Sas6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog.

SH2D3_MOUSE
θ value	θ > 10 (rank : 398)	NC score	0.050453 (rank : 342)
Query Neighborhood Hits	239	Target Neighborhood Hits	174	Shared Neighborhood Hits	20
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SH3G1_HUMAN
θ value	θ > 10 (rank : 399)	NC score	0.065841 (rank : 219)
Query Neighborhood Hits	239	Target Neighborhood Hits	307	Shared Neighborhood Hits	32
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 400)	NC score	0.062148 (rank : 236)
Query Neighborhood Hits	239	Target Neighborhood Hits	291	Shared Neighborhood Hits	27
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 401)	NC score	0.063605 (rank : 231)
Query Neighborhood Hits	239	Target Neighborhood Hits	324	Shared Neighborhood Hits	31
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 402)	NC score	0.061995 (rank : 238)
Query Neighborhood Hits	239	Target Neighborhood Hits	319	Shared Neighborhood Hits	29
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 403)	NC score	0.064500 (rank : 226)
Query Neighborhood Hits	239	Target Neighborhood Hits	222	Shared Neighborhood Hits	20
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 404)	NC score	0.066868 (rank : 211)
Query Neighborhood Hits	239	Target Neighborhood Hits	236	Shared Neighborhood Hits	20
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_HUMAN
θ value	θ > 10 (rank : 405)	NC score	0.114050 (rank : 121)
Query Neighborhood Hits	239	Target Neighborhood Hits	341	Shared Neighborhood Hits	37
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 406)	NC score	0.105877 (rank : 126)
Query Neighborhood Hits	239	Target Neighborhood Hits	332	Shared Neighborhood Hits	35
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SHAN2_MOUSE
θ value	θ > 10 (rank : 407)	NC score	0.063217 (rank : 233)
Query Neighborhood Hits	239	Target Neighborhood Hits	446	Shared Neighborhood Hits	29
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SPTA1_MOUSE
θ value	θ > 10 (rank : 408)	NC score	0.050403 (rank : 345)
Query Neighborhood Hits	239	Target Neighborhood Hits	675	Shared Neighborhood Hits	72
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
θ value	θ > 10 (rank : 409)	NC score	0.055535 (rank : 281)
Query Neighborhood Hits	239	Target Neighborhood Hits	888	Shared Neighborhood Hits	79
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SRBS1_HUMAN
θ value	θ > 10 (rank : 410)	NC score	0.100300 (rank : 130)
Query Neighborhood Hits	239	Target Neighborhood Hits	396	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 411)	NC score	0.107436 (rank : 123)
Query Neighborhood Hits	239	Target Neighborhood Hits	409	Shared Neighborhood Hits	28
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 412)	NC score	0.070803 (rank : 192)
Query Neighborhood Hits	239	Target Neighborhood Hits	269	Shared Neighborhood Hits	23
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 413)	NC score	0.068057 (rank : 202)
Query Neighborhood Hits	239	Target Neighborhood Hits	292	Shared Neighborhood Hits	20
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRGP1_HUMAN
θ value	θ > 10 (rank : 414)	NC score	0.066252 (rank : 215)
Query Neighborhood Hits	239	Target Neighborhood Hits	390	Shared Neighborhood Hits	46
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
θ value	θ > 10 (rank : 415)	NC score	0.063993 (rank : 228)
Query Neighborhood Hits	239	Target Neighborhood Hits	331	Shared Neighborhood Hits	42
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
θ value	θ > 10 (rank : 416)	NC score	0.064073 (rank : 227)
Query Neighborhood Hits	239	Target Neighborhood Hits	324	Shared Neighborhood Hits	43
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

STAC3_HUMAN
θ value	θ > 10 (rank : 417)	NC score	0.072385 (rank : 184)
Query Neighborhood Hits	239	Target Neighborhood Hits	228	Shared Neighborhood Hits	21
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 418)	NC score	0.072899 (rank : 182)
Query Neighborhood Hits	239	Target Neighborhood Hits	232	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 419)	NC score	0.074604 (rank : 173)
Query Neighborhood Hits	239	Target Neighborhood Hits	276	Shared Neighborhood Hits	21
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 420)	NC score	0.072135 (rank : 186)
Query Neighborhood Hits	239	Target Neighborhood Hits	268	Shared Neighborhood Hits	21
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 421)	NC score	0.067075 (rank : 210)
Query Neighborhood Hits	239	Target Neighborhood Hits	271	Shared Neighborhood Hits	22
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 422)	NC score	0.066610 (rank : 212)
Query Neighborhood Hits	239	Target Neighborhood Hits	273	Shared Neighborhood Hits	20
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 423)	NC score	0.065087 (rank : 223)
Query Neighborhood Hits	239	Target Neighborhood Hits	288	Shared Neighborhood Hits	26
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 424)	NC score	0.065254 (rank : 222)
Query Neighborhood Hits	239	Target Neighborhood Hits	285	Shared Neighborhood Hits	22
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

SYCP1_MOUSE
θ value	θ > 10 (rank : 425)	NC score	0.050813 (rank : 334)
Query Neighborhood Hits	239	Target Neighborhood Hits	1456	Shared Neighborhood Hits	93
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

TACC2_MOUSE
θ value	θ > 10 (rank : 426)	NC score	0.051289 (rank : 326)
Query Neighborhood Hits	239	Target Neighborhood Hits	774	Shared Neighborhood Hits	68
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

TARA_MOUSE
θ value	θ > 10 (rank : 427)	NC score	0.062027 (rank : 237)
Query Neighborhood Hits	239	Target Neighborhood Hits	1133	Shared Neighborhood Hits	104
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TAXB1_HUMAN
θ value	θ > 10 (rank : 428)	NC score	0.051564 (rank : 321)
Query Neighborhood Hits	239	Target Neighborhood Hits	829	Shared Neighborhood Hits	70
SwissProt Accessions	Q86VP1, O60398, O95770, Q13311, Q9BQG5, Q9UI88	Gene names	TAX1BP1, T6BP
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 (TRAF6-binding protein).

TCGAP_HUMAN
θ value	θ > 10 (rank : 429)	NC score	0.074895 (rank : 172)
Query Neighborhood Hits	239	Target Neighborhood Hits	872	Shared Neighborhood Hits	44
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 430)	NC score	0.076187 (rank : 168)
Query Neighborhood Hits	239	Target Neighborhood Hits	409	Shared Neighborhood Hits	35
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TRIO_HUMAN
θ value	θ > 10 (rank : 431)	NC score	0.111032 (rank : 122)
Query Neighborhood Hits	239	Target Neighborhood Hits	1580	Shared Neighborhood Hits	112
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

TRIPB_HUMAN
θ value	θ > 10 (rank : 432)	NC score	0.053012 (rank : 303)
Query Neighborhood Hits	239	Target Neighborhood Hits	1587	Shared Neighborhood Hits	93
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

TUFT1_MOUSE
θ value	θ > 10 (rank : 433)	NC score	0.050035 (rank : 356)
Query Neighborhood Hits	239	Target Neighborhood Hits	732	Shared Neighborhood Hits	67
SwissProt Accessions	O08970	Gene names	Tuft1
Domain Architecture
Description	Tuftelin.

VINEX_HUMAN
θ value	θ > 10 (rank : 434)	NC score	0.098039 (rank : 131)
Query Neighborhood Hits	239	Target Neighborhood Hits	270	Shared Neighborhood Hits	22
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 435)	NC score	0.097045 (rank : 134)
Query Neighborhood Hits	239	Target Neighborhood Hits	286	Shared Neighborhood Hits	23
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ZFY16_HUMAN
θ value	θ > 10 (rank : 436)	NC score	0.084251 (rank : 151)
Query Neighborhood Hits	239	Target Neighborhood Hits	125	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY16_MOUSE
θ value	θ > 10 (rank : 437)	NC score	0.086454 (rank : 147)
Query Neighborhood Hits	239	Target Neighborhood Hits	108	Shared Neighborhood Hits	15
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY19_HUMAN
θ value	θ > 10 (rank : 438)	NC score	0.060766 (rank : 246)
Query Neighborhood Hits	239	Target Neighborhood Hits	206	Shared Neighborhood Hits	18
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ZFY19_MOUSE
θ value	θ > 10 (rank : 439)	NC score	0.057163 (rank : 266)
Query Neighborhood Hits	239	Target Neighborhood Hits	143	Shared Neighborhood Hits	18
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

ZFY21_HUMAN
θ value	θ > 10 (rank : 440)	NC score	0.083172 (rank : 154)
Query Neighborhood Hits	239	Target Neighborhood Hits	72	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_MOUSE
θ value	θ > 10 (rank : 441)	NC score	0.085084 (rank : 150)
Query Neighborhood Hits	239	Target Neighborhood Hits	72	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY28_HUMAN
θ value	θ > 10 (rank : 442)	NC score	0.094275 (rank : 138)
Query Neighborhood Hits	239	Target Neighborhood Hits	152	Shared Neighborhood Hits	19
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV1_HUMAN
θ value	θ > 10 (rank : 443)	NC score	0.054509 (rank : 289)
Query Neighborhood Hits	239	Target Neighborhood Hits	166	Shared Neighborhood Hits	20
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
θ value	θ > 10 (rank : 444)	NC score	0.053255 (rank : 300)
Query Neighborhood Hits	239	Target Neighborhood Hits	153	Shared Neighborhood Hits	19
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

ZFYV9_HUMAN
θ value	θ > 10 (rank : 445)	NC score	0.091863 (rank : 141)
Query Neighborhood Hits	239	Target Neighborhood Hits	134	Shared Neighborhood Hits	15
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

Hits sorted by NC score

GNRP_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	239	Target Neighborhood Hits	239	Shared Neighborhood Hits	239
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
NC score	0.978944 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	239	Target Neighborhood Hits	191	Shared Neighborhood Hits	143
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

SOS2_HUMAN
NC score	0.664231 (rank : 3)	θ value	9.20422e-37 (rank : 3)
Query Neighborhood Hits	239	Target Neighborhood Hits	193	Shared Neighborhood Hits	56
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SOS1_HUMAN
NC score	0.656481 (rank : 4)	θ value	1.57e-36 (rank : 5)
Query Neighborhood Hits	239	Target Neighborhood Hits	274	Shared Neighborhood Hits	60
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

RPGF1_HUMAN
NC score	0.653143 (rank : 5)	θ value	1.24399e-33 (rank : 6)
Query Neighborhood Hits	239	Target Neighborhood Hits	262	Shared Neighborhood Hits	24
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

SOS1_MOUSE
NC score	0.648322 (rank : 6)	θ value	1.20211e-36 (rank : 4)
Query Neighborhood Hits	239	Target Neighborhood Hits	281	Shared Neighborhood Hits	56
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

RGL1_HUMAN
NC score	0.622290 (rank : 7)	θ value	8.06329e-33 (rank : 8)
Query Neighborhood Hits	239	Target Neighborhood Hits	43	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL1_MOUSE
NC score	0.610784 (rank : 8)	θ value	2.77131e-33 (rank : 7)
Query Neighborhood Hits	239	Target Neighborhood Hits	42	Shared Neighborhood Hits	25
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

GNDS_MOUSE
NC score	0.575476 (rank : 9)	θ value	4.43474e-23 (rank : 12)
Query Neighborhood Hits	239	Target Neighborhood Hits	115	Shared Neighborhood Hits	24
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RGL2_MOUSE
NC score	0.574171 (rank : 10)	θ value	3.88503e-19 (rank : 16)
Query Neighborhood Hits	239	Target Neighborhood Hits	51	Shared Neighborhood Hits	21
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RGL2_HUMAN
NC score	0.574049 (rank : 11)	θ value	1.24977e-17 (rank : 19)
Query Neighborhood Hits	239	Target Neighborhood Hits	45	Shared Neighborhood Hits	22
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RPGF5_HUMAN
NC score	0.571266 (rank : 12)	θ value	3.07116e-24 (rank : 10)
Query Neighborhood Hits	239	Target Neighborhood Hits	42	Shared Neighborhood Hits	25
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

GNDS_HUMAN
NC score	0.564522 (rank : 13)	θ value	9.87957e-23 (rank : 13)
Query Neighborhood Hits	239	Target Neighborhood Hits	201	Shared Neighborhood Hits	24
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RGDSR_HUMAN
NC score	0.563524 (rank : 14)	θ value	1.13037e-18 (rank : 17)
Query Neighborhood Hits	239	Target Neighborhood Hits	63	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

RPGF5_MOUSE
NC score	0.562974 (rank : 15)	θ value	4.01107e-24 (rank : 11)
Query Neighborhood Hits	239	Target Neighborhood Hits	85	Shared Neighborhood Hits	28
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

ECT2_MOUSE
NC score	0.532664 (rank : 16)	θ value	1.86753e-13 (rank : 30)
Query Neighborhood Hits	239	Target Neighborhood Hits	98	Shared Neighborhood Hits	60
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_HUMAN
NC score	0.527999 (rank : 17)	θ value	1.2105e-12 (rank : 34)
Query Neighborhood Hits	239	Target Neighborhood Hits	98	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

GRP3_HUMAN
NC score	0.524678 (rank : 18)	θ value	2.12685e-25 (rank : 9)
Query Neighborhood Hits	239	Target Neighborhood Hits	131	Shared Neighborhood Hits	29
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

RPGF4_HUMAN
NC score	0.522333 (rank : 19)	θ value	7.0802e-21 (rank : 14)
Query Neighborhood Hits	239	Target Neighborhood Hits	88	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

PREX1_HUMAN
NC score	0.521983 (rank : 20)	θ value	1.38499e-08 (rank : 53)
Query Neighborhood Hits	239	Target Neighborhood Hits	177	Shared Neighborhood Hits	75
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

RPGF4_MOUSE
NC score	0.519281 (rank : 21)	θ value	3.51386e-20 (rank : 15)
Query Neighborhood Hits	239	Target Neighborhood Hits	80	Shared Neighborhood Hits	26
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF2_HUMAN
NC score	0.505382 (rank : 22)	θ value	1.92812e-18 (rank : 18)
Query Neighborhood Hits	239	Target Neighborhood Hits	242	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

NGEF_HUMAN
NC score	0.495835 (rank : 23)	θ value	3.89403e-11 (rank : 42)
Query Neighborhood Hits	239	Target Neighborhood Hits	166	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

FGD3_MOUSE
NC score	0.493849 (rank : 24)	θ value	1.02475e-11 (rank : 39)
Query Neighborhood Hits	239	Target Neighborhood Hits	257	Shared Neighborhood Hits	72
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD2_HUMAN
NC score	0.489449 (rank : 25)	θ value	1.86753e-13 (rank : 31)
Query Neighborhood Hits	239	Target Neighborhood Hits	151	Shared Neighborhood Hits	70
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD4_HUMAN
NC score	0.489140 (rank : 26)	θ value	3.76295e-14 (rank : 26)
Query Neighborhood Hits	239	Target Neighborhood Hits	219	Shared Neighborhood Hits	83
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

RPGF3_HUMAN
NC score	0.487334 (rank : 27)	θ value	9.90251e-15 (rank : 23)
Query Neighborhood Hits	239	Target Neighborhood Hits	56	Shared Neighborhood Hits	24
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

FGD4_MOUSE
NC score	0.486040 (rank : 28)	θ value	6.00763e-12 (rank : 37)
Query Neighborhood Hits	239	Target Neighborhood Hits	227	Shared Neighborhood Hits	80
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

RPGF6_HUMAN
NC score	0.485388 (rank : 29)	θ value	1.63225e-17 (rank : 20)
Query Neighborhood Hits	239	Target Neighborhood Hits	266	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

NGEF_MOUSE
NC score	0.481068 (rank : 30)	θ value	3.52202e-12 (rank : 36)
Query Neighborhood Hits	239	Target Neighborhood Hits	228	Shared Neighborhood Hits	59
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

FGD3_HUMAN
NC score	0.480701 (rank : 31)	θ value	2.28291e-11 (rank : 40)
Query Neighborhood Hits	239	Target Neighborhood Hits	249	Shared Neighborhood Hits	60
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD2_MOUSE
NC score	0.475940 (rank : 32)	θ value	2.60593e-15 (rank : 22)
Query Neighborhood Hits	239	Target Neighborhood Hits	163	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

ARHG5_HUMAN
NC score	0.470069 (rank : 33)	θ value	5.62301e-10 (rank : 46)
Query Neighborhood Hits	239	Target Neighborhood Hits	172	Shared Neighborhood Hits	57
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

RPGF3_MOUSE
NC score	0.469484 (rank : 34)	θ value	1.29331e-14 (rank : 24)
Query Neighborhood Hits	239	Target Neighborhood Hits	54	Shared Neighborhood Hits	21
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

ARHGA_HUMAN
NC score	0.467490 (rank : 35)	θ value	7.09661e-13 (rank : 33)
Query Neighborhood Hits	239	Target Neighborhood Hits	187	Shared Neighborhood Hits	64
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

FGD1_HUMAN
NC score	0.463663 (rank : 36)	θ value	5.62301e-10 (rank : 47)
Query Neighborhood Hits	239	Target Neighborhood Hits	367	Shared Neighborhood Hits	78
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ARHGA_MOUSE
NC score	0.462904 (rank : 37)	θ value	1.02475e-11 (rank : 38)
Query Neighborhood Hits	239	Target Neighborhood Hits	125	Shared Neighborhood Hits	59
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

FGD1_MOUSE
NC score	0.462709 (rank : 38)	θ value	3.29651e-10 (rank : 45)
Query Neighborhood Hits	239	Target Neighborhood Hits	387	Shared Neighborhood Hits	76
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ARHGG_MOUSE
NC score	0.449808 (rank : 39)	θ value	4.0297e-08 (rank : 55)
Query Neighborhood Hits	239	Target Neighborhood Hits	152	Shared Neighborhood Hits	55
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG3_HUMAN
NC score	0.441799 (rank : 40)	θ value	3.64472e-09 (rank : 49)
Query Neighborhood Hits	239	Target Neighborhood Hits	82	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHGG_HUMAN
NC score	0.441077 (rank : 41)	θ value	1.29631e-06 (rank : 61)
Query Neighborhood Hits	239	Target Neighborhood Hits	129	Shared Neighborhood Hits	56
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG3_MOUSE
NC score	0.440979 (rank : 42)	θ value	8.11959e-09 (rank : 50)
Query Neighborhood Hits	239	Target Neighborhood Hits	85	Shared Neighborhood Hits	52
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

FGD6_MOUSE
NC score	0.434903 (rank : 43)	θ value	1.2105e-12 (rank : 35)
Query Neighborhood Hits	239	Target Neighborhood Hits	282	Shared Neighborhood Hits	81
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

ARHGF_HUMAN
NC score	0.429546 (rank : 44)	θ value	2.36244e-08 (rank : 54)
Query Neighborhood Hits	239	Target Neighborhood Hits	214	Shared Neighborhood Hits	50
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

FGD6_HUMAN
NC score	0.427581 (rank : 45)	θ value	2.28291e-11 (rank : 41)
Query Neighborhood Hits	239	Target Neighborhood Hits	237	Shared Neighborhood Hits	88
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

ARHG8_HUMAN
NC score	0.425636 (rank : 46)	θ value	3.77169e-06 (rank : 65)
Query Neighborhood Hits	239	Target Neighborhood Hits	85	Shared Neighborhood Hits	54
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG4_HUMAN
NC score	0.425231 (rank : 47)	θ value	4.92598e-06 (rank : 66)
Query Neighborhood Hits	239	Target Neighborhood Hits	242	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

TIAM1_MOUSE
NC score	0.424403 (rank : 48)	θ value	1.53129e-07 (rank : 59)
Query Neighborhood Hits	239	Target Neighborhood Hits	205	Shared Neighborhood Hits	75
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_HUMAN
NC score	0.422390 (rank : 49)	θ value	1.53129e-07 (rank : 58)
Query Neighborhood Hits	239	Target Neighborhood Hits	225	Shared Neighborhood Hits	75
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG4_MOUSE
NC score	0.421221 (rank : 50)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	239	Target Neighborhood Hits	185	Shared Neighborhood Hits	58
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG9_HUMAN
NC score	0.400491 (rank : 51)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	239	Target Neighborhood Hits	235	Shared Neighborhood Hits	59
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.400016 (rank : 52)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	239	Target Neighborhood Hits	234	Shared Neighborhood Hits	59
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG8_MOUSE
NC score	0.398141 (rank : 53)	θ value	8.40245e-06 (rank : 68)
Query Neighborhood Hits	239	Target Neighborhood Hits	79	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

PKHG1_HUMAN
NC score	0.398111 (rank : 54)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	239	Target Neighborhood Hits	174	Shared Neighborhood Hits	64
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

VAV2_HUMAN
NC score	0.364485 (rank : 55)	θ value	2.52405e-10 (rank : 44)
Query Neighborhood Hits	239	Target Neighborhood Hits	453	Shared Neighborhood Hits	67
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
NC score	0.362422 (rank : 56)	θ value	8.11959e-09 (rank : 51)
Query Neighborhood Hits	239	Target Neighborhood Hits	456	Shared Neighborhood Hits	69
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

BCR_HUMAN
NC score	0.353892 (rank : 57)	θ value	1.09485e-13 (rank : 29)
Query Neighborhood Hits	239	Target Neighborhood Hits	204	Shared Neighborhood Hits	58
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ARHGB_HUMAN
NC score	0.352634 (rank : 58)	θ value	2.21117e-06 (rank : 64)
Query Neighborhood Hits	239	Target Neighborhood Hits	375	Shared Neighborhood Hits	64
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ABR_HUMAN
NC score	0.349998 (rank : 59)	θ value	3.07829e-16 (rank : 21)
Query Neighborhood Hits	239	Target Neighborhood Hits	166	Shared Neighborhood Hits	59
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ARHG7_HUMAN
NC score	0.349872 (rank : 60)	θ value	1.29631e-06 (rank : 60)
Query Neighborhood Hits	239	Target Neighborhood Hits	347	Shared Neighborhood Hits	69
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

DNMBP_MOUSE
NC score	0.347843 (rank : 61)	θ value	6.87365e-08 (rank : 56)
Query Neighborhood Hits	239	Target Neighborhood Hits	435	Shared Neighborhood Hits	63
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

VAV3_MOUSE
NC score	0.346860 (rank : 62)	θ value	1.69304e-06 (rank : 62)
Query Neighborhood Hits	239	Target Neighborhood Hits	404	Shared Neighborhood Hits	63
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ARHG7_MOUSE
NC score	0.345437 (rank : 63)	θ value	4.92598e-06 (rank : 67)
Query Neighborhood Hits	239	Target Neighborhood Hits	396	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

FARP2_MOUSE
NC score	0.345352 (rank : 64)	θ value	1.9326e-10 (rank : 43)
Query Neighborhood Hits	239	Target Neighborhood Hits	209	Shared Neighborhood Hits	90
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

VAV3_HUMAN
NC score	0.340445 (rank : 65)	θ value	1.87187e-05 (rank : 69)
Query Neighborhood Hits	239	Target Neighborhood Hits	398	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ITSN2_HUMAN
NC score	0.336558 (rank : 66)	θ value	3.76295e-14 (rank : 27)
Query Neighborhood Hits	239	Target Neighborhood Hits	1173	Shared Neighborhood Hits	113
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

VAV_MOUSE
NC score	0.330545 (rank : 67)	θ value	1.69304e-06 (rank : 63)
Query Neighborhood Hits	239	Target Neighborhood Hits	430	Shared Neighborhood Hits	64
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV_HUMAN
NC score	0.325372 (rank : 68)	θ value	1.06045e-08 (rank : 52)
Query Neighborhood Hits	239	Target Neighborhood Hits	452	Shared Neighborhood Hits	67
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ITSN1_MOUSE
NC score	0.325257 (rank : 69)	θ value	4.91457e-14 (rank : 28)
Query Neighborhood Hits	239	Target Neighborhood Hits	1669	Shared Neighborhood Hits	130
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN1_HUMAN
NC score	0.324006 (rank : 70)	θ value	2.88119e-14 (rank : 25)
Query Neighborhood Hits	239	Target Neighborhood Hits	1757	Shared Neighborhood Hits	133
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN2_MOUSE
NC score	0.321015 (rank : 71)	θ value	4.16044e-13 (rank : 32)
Query Neighborhood Hits	239	Target Neighborhood Hits	1371	Shared Neighborhood Hits	121
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

DNMBP_HUMAN
NC score	0.317473 (rank : 72)	θ value	0.000270298 (rank : 75)
Query Neighborhood Hits	239	Target Neighborhood Hits	413	Shared Neighborhood Hits	66
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

RGNEF_MOUSE
NC score	0.312660 (rank : 73)	θ value	1.25267e-09 (rank : 48)
Query Neighborhood Hits	239	Target Neighborhood Hits	641	Shared Neighborhood Hits	89
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ARHG6_HUMAN
NC score	0.307615 (rank : 74)	θ value	0.00175202 (rank : 79)
Query Neighborhood Hits	239	Target Neighborhood Hits	376	Shared Neighborhood Hits	70
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

FARP2_HUMAN
NC score	0.307150 (rank : 75)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	239	Target Neighborhood Hits	240	Shared Neighborhood Hits	84
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

MCF2_HUMAN
NC score	0.306079 (rank : 76)	θ value	8.99809 (rank : 227)
Query Neighborhood Hits	239	Target Neighborhood Hits	166	Shared Neighborhood Hits	69
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ARHG1_HUMAN
NC score	0.305670 (rank : 77)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	239	Target Neighborhood Hits	176	Shared Neighborhood Hits	52
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

FGD5_HUMAN
NC score	0.301161 (rank : 78)	θ value	4.03905 (rank : 177)
Query Neighborhood Hits	239	Target Neighborhood Hits	235	Shared Neighborhood Hits	67
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

ARHG1_MOUSE
NC score	0.299574 (rank : 79)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	239	Target Neighborhood Hits	266	Shared Neighborhood Hits	53
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

FGD5_MOUSE
NC score	0.294328 (rank : 80)	θ value	3.0926 (rank : 165)
Query Neighborhood Hits	239	Target Neighborhood Hits	170	Shared Neighborhood Hits	66
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

ARHG6_MOUSE
NC score	0.292077 (rank : 81)	θ value	0.00390308 (rank : 87)
Query Neighborhood Hits	239	Target Neighborhood Hits	394	Shared Neighborhood Hits	74
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

FARP1_HUMAN
NC score	0.287281 (rank : 82)	θ value	8.97725e-08 (rank : 57)
Query Neighborhood Hits	239	Target Neighborhood Hits	241	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

ARHG2_MOUSE
NC score	0.286911 (rank : 83)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	239	Target Neighborhood Hits	120	Shared Neighborhood Hits	54
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHGC_MOUSE
NC score	0.283226 (rank : 84)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	239	Target Neighborhood Hits	344	Shared Neighborhood Hits	69
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

MCF2L_MOUSE
NC score	0.282582 (rank : 85)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	239	Target Neighborhood Hits	255	Shared Neighborhood Hits	73
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

ARHGC_HUMAN
NC score	0.279874 (rank : 86)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	239	Target Neighborhood Hits	351	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

LBC_HUMAN
NC score	0.277328 (rank : 87)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	239	Target Neighborhood Hits	90	Shared Neighborhood Hits	47
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

HAPIP_HUMAN
NC score	0.276021 (rank : 88)	θ value	0.0961366 (rank : 104)
Query Neighborhood Hits	239	Target Neighborhood Hits	350	Shared Neighborhood Hits	95
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ARHG2_HUMAN
NC score	0.275466 (rank : 89)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	239	Target Neighborhood Hits	142	Shared Neighborhood Hits	51
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

PKHG4_HUMAN
NC score	0.215269 (rank : 90)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	239	Target Neighborhood Hits	200	Shared Neighborhood Hits	52
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

PKHA6_MOUSE
NC score	0.192919 (rank : 91)	θ value	0.000461057 (rank : 76)
Query Neighborhood Hits	239	Target Neighborhood Hits	591	Shared Neighborhood Hits	97
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_HUMAN
NC score	0.186622 (rank : 92)	θ value	0.00228821 (rank : 83)
Query Neighborhood Hits	239	Target Neighborhood Hits	556	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PLEK2_HUMAN
NC score	0.176206 (rank : 93)	θ value	0.00175202 (rank : 82)
Query Neighborhood Hits	239	Target Neighborhood Hits	101	Shared Neighborhood Hits	49
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_MOUSE
NC score	0.169383 (rank : 94)	θ value	0.00298849 (rank : 86)
Query Neighborhood Hits	239	Target Neighborhood Hits	96	Shared Neighborhood Hits	48
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

CYH4_HUMAN
NC score	0.163528 (rank : 95)	θ value	4.1701e-05 (rank : 70)
Query Neighborhood Hits	239	Target Neighborhood Hits	135	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

PLEK_MOUSE
NC score	0.163064 (rank : 96)	θ value	0.0252991 (rank : 96)
Query Neighborhood Hits	239	Target Neighborhood Hits	109	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

CYH4_MOUSE
NC score	0.162353 (rank : 97)	θ value	0.000158464 (rank : 74)
Query Neighborhood Hits	239	Target Neighborhood Hits	134	Shared Neighborhood Hits	54
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

PLEK_HUMAN
NC score	0.159033 (rank : 98)	θ value	0.0736092 (rank : 103)
Query Neighborhood Hits	239	Target Neighborhood Hits	110	Shared Neighborhood Hits	48
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PKHA4_MOUSE
NC score	0.157877 (rank : 99)	θ value	0.0736092 (rank : 102)
Query Neighborhood Hits	239	Target Neighborhood Hits	202	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

CYH3_MOUSE
NC score	0.157615 (rank : 100)	θ value	0.00134147 (rank : 77)
Query Neighborhood Hits	239	Target Neighborhood Hits	148	Shared Neighborhood Hits	59
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

PKHA5_HUMAN
NC score	0.150324 (rank : 101)	θ value	0.00390308 (rank : 88)
Query Neighborhood Hits	239	Target Neighborhood Hits	455	Shared Neighborhood Hits	91
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

SWP70_HUMAN
NC score	0.149568 (rank : 102)	θ value	0.000121331 (rank : 73)
Query Neighborhood Hits	239	Target Neighborhood Hits	973	Shared Neighborhood Hits	115
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

PKHA4_HUMAN
NC score	0.148804 (rank : 103)	θ value	0.125558 (rank : 110)
Query Neighborhood Hits	239	Target Neighborhood Hits	283	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHF2_MOUSE
NC score	0.148639 (rank : 104)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	239	Target Neighborhood Hits	77	Shared Neighborhood Hits	25
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHF2_HUMAN
NC score	0.148097 (rank : 105)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	239	Target Neighborhood Hits	75	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

CYH3_HUMAN
NC score	0.147871 (rank : 106)	θ value	0.00175202 (rank : 80)
Query Neighborhood Hits	239	Target Neighborhood Hits	137	Shared Neighborhood Hits	50
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

CYH2_HUMAN
NC score	0.147680 (rank : 107)	θ value	0.00665767 (rank : 90)
Query Neighborhood Hits	239	Target Neighborhood Hits	175	Shared Neighborhood Hits	58
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
NC score	0.147296 (rank : 108)	θ value	0.00665767 (rank : 91)
Query Neighborhood Hits	239	Target Neighborhood Hits	171	Shared Neighborhood Hits	55
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH1_HUMAN
NC score	0.145699 (rank : 109)	θ value	0.0113563 (rank : 93)
Query Neighborhood Hits	239	Target Neighborhood Hits	184	Shared Neighborhood Hits	63
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

SWP70_MOUSE
NC score	0.144054 (rank : 110)	θ value	7.1131e-05 (rank : 71)
Query Neighborhood Hits	239	Target Neighborhood Hits	1097	Shared Neighborhood Hits	119
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

CYH1_MOUSE
NC score	0.143737 (rank : 111)	θ value	0.0113563 (rank : 94)
Query Neighborhood Hits	239	Target Neighborhood Hits	176	Shared Neighborhood Hits	61
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

RHG25_HUMAN
NC score	0.139134 (rank : 112)	θ value	0.00665767 (rank : 92)
Query Neighborhood Hits	239	Target Neighborhood Hits	550	Shared Neighborhood Hits	106
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

DAPP1_MOUSE
NC score	0.137850 (rank : 113)	θ value	0.00134147 (rank : 78)
Query Neighborhood Hits	239	Target Neighborhood Hits	225	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PKHF1_HUMAN
NC score	0.137741 (rank : 114)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	239	Target Neighborhood Hits	76	Shared Neighborhood Hits	21
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

RHG25_MOUSE
NC score	0.136550 (rank : 115)	θ value	0.0252991 (rank : 97)
Query Neighborhood Hits	239	Target Neighborhood Hits	492	Shared Neighborhood Hits	94
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

DAPP1_HUMAN
NC score	0.136032 (rank : 116)	θ value	0.00175202 (rank : 81)
Query Neighborhood Hits	239	Target Neighborhood Hits	227	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PKHF1_MOUSE
NC score	0.135941 (rank : 117)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	239	Target Neighborhood Hits	80	Shared Neighborhood Hits	20
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

3BP2_MOUSE
NC score	0.127276 (rank : 118)	θ value	0.163984 (rank : 111)
Query Neighborhood Hits	239	Target Neighborhood Hits	142	Shared Neighborhood Hits	37
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

3BP2_HUMAN
NC score	0.124888 (rank : 119)	θ value	0.21417 (rank : 112)
Query Neighborhood Hits	239	Target Neighborhood Hits	296	Shared Neighborhood Hits	39
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

DUET_HUMAN
NC score	0.117994 (rank : 120)	θ value	0.000121331 (rank : 72)
Query Neighborhood Hits	239	Target Neighborhood Hits	1220	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

SH3K1_HUMAN
NC score	0.114050 (rank : 121)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	239	Target Neighborhood Hits	341	Shared Neighborhood Hits	37
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

TRIO_HUMAN
NC score	0.111032 (rank : 122)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	239	Target Neighborhood Hits	1580	Shared Neighborhood Hits	112
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

SRBS1_MOUSE
NC score	0.107436 (rank : 123)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	239	Target Neighborhood Hits	409	Shared Neighborhood Hits	28
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

CNKR1_HUMAN
NC score	0.106620 (rank : 124)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	239	Target Neighborhood Hits	154	Shared Neighborhood Hits	37
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CD2AP_MOUSE
NC score	0.106112 (rank : 125)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	239	Target Neighborhood Hits	336	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

SH3K1_MOUSE
NC score	0.105877 (rank : 126)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	239	Target Neighborhood Hits	332	Shared Neighborhood Hits	35
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

CD2AP_HUMAN
NC score	0.104104 (rank : 127)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	239	Target Neighborhood Hits	315	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

NCF1_HUMAN
NC score	0.100700 (rank : 128)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	239	Target Neighborhood Hits	198	Shared Neighborhood Hits	22
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCK1_HUMAN
NC score	0.100324 (rank : 129)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	239	Target Neighborhood Hits	312	Shared Neighborhood Hits	26
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SRBS1_HUMAN
NC score	0.100300 (rank : 130)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	239	Target Neighborhood Hits	396	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

VINEX_HUMAN
NC score	0.098039 (rank : 131)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	239	Target Neighborhood Hits	270	Shared Neighborhood Hits	22
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

NCF2_HUMAN
NC score	0.097607 (rank : 132)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	239	Target Neighborhood Hits	229	Shared Neighborhood Hits	23
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF1_MOUSE
NC score	0.097324 (rank : 133)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	239	Target Neighborhood Hits	198	Shared Neighborhood Hits	22
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

VINEX_MOUSE
NC score	0.097045 (rank : 134)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	239	Target Neighborhood Hits	286	Shared Neighborhood Hits	23
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

NCK2_HUMAN
NC score	0.095987 (rank : 135)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	239	Target Neighborhood Hits	310	Shared Neighborhood Hits	26
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

OSB11_MOUSE
NC score	0.094790 (rank : 136)	θ value	0.00298849 (rank : 85)
Query Neighborhood Hits	239	Target Neighborhood Hits	71	Shared Neighborhood Hits	28
SwissProt Accessions	Q8CI95	Gene names	Osbpl11
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

OSBL9_HUMAN
NC score	0.094587 (rank : 137)	θ value	4.03905 (rank : 182)
Query Neighborhood Hits	239	Target Neighborhood Hits	138	Shared Neighborhood Hits	51
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

ZFY28_HUMAN
NC score	0.094275 (rank : 138)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	239	Target Neighborhood Hits	152	Shared Neighborhood Hits	19
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

PKHA2_MOUSE
NC score	0.093294 (rank : 139)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	239	Target Neighborhood Hits	116	Shared Neighborhood Hits	52
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

OSB11_HUMAN
NC score	0.092706 (rank : 140)	θ value	0.00298849 (rank : 84)
Query Neighborhood Hits	239	Target Neighborhood Hits	60	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BXB4	Gene names	OSBPL11, ORP11, OSBP12
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

ZFYV9_HUMAN
NC score	0.091863 (rank : 141)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	239	Target Neighborhood Hits	134	Shared Neighborhood Hits	15
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

PKHA1_HUMAN
NC score	0.091539 (rank : 142)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	239	Target Neighborhood Hits	127	Shared Neighborhood Hits	44
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
NC score	0.090051 (rank : 143)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	239	Target Neighborhood Hits	120	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

GRAP_HUMAN
NC score	0.088312 (rank : 144)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	239	Target Neighborhood Hits	307	Shared Neighborhood Hits	22
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
NC score	0.088216 (rank : 145)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	239	Target Neighborhood Hits	309	Shared Neighborhood Hits	22
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

C43BP_MOUSE
NC score	0.087252 (rank : 146)	θ value	0.62314 (rank : 125)
Query Neighborhood Hits	239	Target Neighborhood Hits	91	Shared Neighborhood Hits	35
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

ZFY16_MOUSE
NC score	0.086454 (rank : 147)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	239	Target Neighborhood Hits	108	Shared Neighborhood Hits	15
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

PKHA2_HUMAN
NC score	0.086288 (rank : 148)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	239	Target Neighborhood Hits	119	Shared Neighborhood Hits	49
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHA3_MOUSE
NC score	0.085264 (rank : 149)	θ value	3.0926 (rank : 170)
Query Neighborhood Hits	239	Target Neighborhood Hits	67	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

ZFY21_MOUSE
NC score	0.085084 (rank : 150)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	239	Target Neighborhood Hits	72	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY16_HUMAN
NC score	0.084251 (rank : 151)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	239	Target Neighborhood Hits	125	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

CNKR2_MOUSE
NC score	0.083434 (rank : 152)	θ value	2.36792 (rank : 158)
Query Neighborhood Hits	239	Target Neighborhood Hits	197	Shared Neighborhood Hits	39
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.083425 (rank : 153)	θ value	2.36792 (rank : 157)
Query Neighborhood Hits	239	Target Neighborhood Hits	197	Shared Neighborhood Hits	40
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

ZFY21_HUMAN
NC score	0.083172 (rank : 154)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	239	Target Neighborhood Hits	72	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

RUFY2_MOUSE
NC score	0.082818 (rank : 155)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	239	Target Neighborhood Hits	820	Shared Neighborhood Hits	83
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

C43BP_HUMAN
NC score	0.082293 (rank : 156)	θ value	1.38821 (rank : 141)
Query Neighborhood Hits	239	Target Neighborhood Hits	87	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

RUFY2_HUMAN
NC score	0.079520 (rank : 157)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	239	Target Neighborhood Hits	1208	Shared Neighborhood Hits	90
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

EEA1_MOUSE
NC score	0.079223 (rank : 158)	θ value	0.365318 (rank : 117)
Query Neighborhood Hits	239	Target Neighborhood Hits	1637	Shared Neighborhood Hits	100
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

ABI2_MOUSE
NC score	0.078905 (rank : 159)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	239	Target Neighborhood Hits	266	Shared Neighborhood Hits	23
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

GRB2_HUMAN
NC score	0.078729 (rank : 160)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	239	Target Neighborhood Hits	310	Shared Neighborhood Hits	21
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.078687 (rank : 161)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	239	Target Neighborhood Hits	312	Shared Neighborhood Hits	21
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

ABI2_HUMAN
NC score	0.078555 (rank : 162)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	239	Target Neighborhood Hits	350	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

K1914_HUMAN
NC score	0.078464 (rank : 163)	θ value	0.0961366 (rank : 105)
Query Neighborhood Hits	239	Target Neighborhood Hits	255	Shared Neighborhood Hits	52
SwissProt Accessions	Q8N4X5, Q8TB54, Q96PX4, Q96SY5	Gene names	KIAA1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

EEA1_HUMAN
NC score	0.077984 (rank : 164)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	239	Target Neighborhood Hits	1796	Shared Neighborhood Hits	104
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

PLCG1_MOUSE
NC score	0.077817 (rank : 165)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	239	Target Neighborhood Hits	314	Shared Neighborhood Hits	27
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PPIP1_HUMAN
NC score	0.077304 (rank : 166)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	239	Target Neighborhood Hits	389	Shared Neighborhood Hits	52
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

RUFY1_HUMAN
NC score	0.076556 (rank : 167)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	239	Target Neighborhood Hits	848	Shared Neighborhood Hits	83
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

TCGAP_MOUSE
NC score	0.076187 (rank : 168)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	239	Target Neighborhood Hits	409	Shared Neighborhood Hits	35
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

PLCG1_HUMAN
NC score	0.076175 (rank : 169)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	239	Target Neighborhood Hits	293	Shared Neighborhood Hits	27
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

AZI1_HUMAN
NC score	0.075423 (rank : 170)	θ value	0.0736092 (rank : 100)
Query Neighborhood Hits	239	Target Neighborhood Hits	1000	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

ABI1_MOUSE
NC score	0.075338 (rank : 171)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	239	Target Neighborhood Hits	246	Shared Neighborhood Hits	22
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

TCGAP_HUMAN
NC score	0.074895 (rank : 172)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	239	Target Neighborhood Hits	872	Shared Neighborhood Hits	44
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

STAC_HUMAN
NC score	0.074604 (rank : 173)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	239	Target Neighborhood Hits	276	Shared Neighborhood Hits	21
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

RBNS5_HUMAN
NC score	0.074137 (rank : 174)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	239	Target Neighborhood Hits	242	Shared Neighborhood Hits	29
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

NCF4_MOUSE
NC score	0.073936 (rank : 175)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	239	Target Neighborhood Hits	177	Shared Neighborhood Hits	19
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

RBNS5_MOUSE
NC score	0.073879 (rank : 176)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	239	Target Neighborhood Hits	266	Shared Neighborhood Hits	36
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

HGS_MOUSE
NC score	0.073781 (rank : 177)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	239	Target Neighborhood Hits	589	Shared Neighborhood Hits	40
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

RUFY1_MOUSE
NC score	0.073557 (rank : 178)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	239	Target Neighborhood Hits	765	Shared Neighborhood Hits	76
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

HGS_HUMAN
NC score	0.073477 (rank : 179)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	239	Target Neighborhood Hits	517	Shared Neighborhood Hits	35
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

NCF4_HUMAN
NC score	0.073274 (rank : 180)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	239	Target Neighborhood Hits	161	Shared Neighborhood Hits	17
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

HCLS1_HUMAN
NC score	0.072935 (rank : 181)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	239	Target Neighborhood Hits	358	Shared Neighborhood Hits	24
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

STAC3_MOUSE
NC score	0.072899 (rank : 182)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	239	Target Neighborhood Hits	232	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

RHG04_HUMAN
NC score	0.072707 (rank : 183)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	239	Target Neighborhood Hits	307	Shared Neighborhood Hits	32
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

STAC3_HUMAN
NC score	0.072385 (rank : 184)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	239	Target Neighborhood Hits	228	Shared Neighborhood Hits	21
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ABI1_HUMAN
NC score	0.072148 (rank : 185)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	239	Target Neighborhood Hits	257	Shared Neighborhood Hits	24
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

STAC_MOUSE
NC score	0.072135 (rank : 186)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	239	Target Neighborhood Hits	268	Shared Neighborhood Hits	21
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

AZI1_MOUSE
NC score	0.071875 (rank : 187)	θ value	0.125558 (rank : 106)
Query Neighborhood Hits	239	Target Neighborhood Hits	990	Shared Neighborhood Hits	79
SwissProt Accessions	Q62036	Gene names	Azi1, Az1, Azi
Domain Architecture
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1).

HCLS1_MOUSE
NC score	0.071795 (rank : 188)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	239	Target Neighborhood Hits	329	Shared Neighborhood Hits	24
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

CRKL_HUMAN
NC score	0.071546 (rank : 189)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	239	Target Neighborhood Hits	313	Shared Neighborhood Hits	21
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

PPIP1_MOUSE
NC score	0.071276 (rank : 190)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	239	Target Neighborhood Hits	377	Shared Neighborhood Hits	41
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

CT152_HUMAN
NC score	0.070828 (rank : 191)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	239	Target Neighborhood Hits	30	Shared Neighborhood Hits	6
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

SRC8_HUMAN
NC score	0.070803 (rank : 192)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	239	Target Neighborhood Hits	269	Shared Neighborhood Hits	23
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

CRKL_MOUSE
NC score	0.070361 (rank : 193)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	239	Target Neighborhood Hits	307	Shared Neighborhood Hits	21
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

FYV1_HUMAN
NC score	0.070219 (rank : 194)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	239	Target Neighborhood Hits	217	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

ABI3_HUMAN
NC score	0.069907 (rank : 195)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	239	Target Neighborhood Hits	227	Shared Neighborhood Hits	22
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

BI2L1_HUMAN
NC score	0.069590 (rank : 196)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	239	Target Neighborhood Hits	156	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

DGKH_HUMAN
NC score	0.069427 (rank : 197)	θ value	1.81305 (rank : 150)
Query Neighborhood Hits	239	Target Neighborhood Hits	255	Shared Neighborhood Hits	53
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

PKHA3_HUMAN
NC score	0.069252 (rank : 198)	θ value	8.99809 (rank : 232)
Query Neighborhood Hits	239	Target Neighborhood Hits	66	Shared Neighborhood Hits	33
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

FYV1_MOUSE
NC score	0.069243 (rank : 199)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	239	Target Neighborhood Hits	191	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

FYCO1_HUMAN
NC score	0.069241 (rank : 200)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	239	Target Neighborhood Hits	1149	Shared Neighborhood Hits	89
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

PSD3_HUMAN
NC score	0.068885 (rank : 201)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	239	Target Neighborhood Hits	75	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

SRC8_MOUSE
NC score	0.068057 (rank : 202)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	239	Target Neighborhood Hits	292	Shared Neighborhood Hits	20
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

CRK_MOUSE
NC score	0.068055 (rank : 203)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	239	Target Neighborhood Hits	314	Shared Neighborhood Hits	22
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

FYCO1_MOUSE
NC score	0.067842 (rank : 204)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	239	Target Neighborhood Hits	1059	Shared Neighborhood Hits	88
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

RHG26_HUMAN
NC score	0.067789 (rank : 205)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	239	Target Neighborhood Hits	281	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

EP15R_MOUSE
NC score	0.067597 (rank : 206)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	239	Target Neighborhood Hits	1135	Shared Neighborhood Hits	82
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

NEBL_HUMAN
NC score	0.067252 (rank : 207)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	239	Target Neighborhood Hits	457	Shared Neighborhood Hits	53
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

ABI3_MOUSE
NC score	0.067178 (rank : 208)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	239	Target Neighborhood Hits	227	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

FNBP2_HUMAN
NC score	0.067168 (rank : 209)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	239	Target Neighborhood Hits	432	Shared Neighborhood Hits	60
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

STAM1_HUMAN
NC score	0.067075 (rank : 210)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	239	Target Neighborhood Hits	271	Shared Neighborhood Hits	22
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

SH3G3_MOUSE
NC score	0.066868 (rank : 211)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	239	Target Neighborhood Hits	236	Shared Neighborhood Hits	20
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

STAM1_MOUSE
NC score	0.066610 (rank : 212)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	239	Target Neighborhood Hits	273	Shared Neighborhood Hits	20
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

MYO10_HUMAN
NC score	0.066481 (rank : 213)	θ value	0.0330416 (rank : 98)
Query Neighborhood Hits	239	Target Neighborhood Hits	920	Shared Neighborhood Hits	102
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

EP15_HUMAN
NC score	0.066424 (rank : 214)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	239	Target Neighborhood Hits	1021	Shared Neighborhood Hits	79
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

SRGP1_HUMAN
NC score	0.066252 (rank : 215)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	239	Target Neighborhood Hits	390	Shared Neighborhood Hits	46
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

CRK_HUMAN
NC score	0.066223 (rank : 216)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	239	Target Neighborhood Hits	308	Shared Neighborhood Hits	21
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

GRAP2_MOUSE
NC score	0.066065 (rank : 217)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	239	Target Neighborhood Hits	297	Shared Neighborhood Hits	19
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP2_HUMAN
NC score	0.065923 (rank : 218)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	239	Target Neighborhood Hits	304	Shared Neighborhood Hits	19
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

SH3G1_HUMAN
NC score	0.065841 (rank : 219)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	239	Target Neighborhood Hits	307	Shared Neighborhood Hits	32
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

EP15R_HUMAN
NC score	0.065780 (rank : 220)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	239	Target Neighborhood Hits	1083	Shared Neighborhood Hits	82
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

NOXO1_MOUSE
NC score	0.065501 (rank : 221)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	239	Target Neighborhood Hits	114	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

STAM2_MOUSE
NC score	0.065254 (rank : 222)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	239	Target Neighborhood Hits	285	Shared Neighborhood Hits	22
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STAM2_HUMAN
NC score	0.065087 (rank : 223)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	239	Target Neighborhood Hits	288	Shared Neighborhood Hits	26
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

P85A_HUMAN
NC score	0.064866 (rank : 224)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	239	Target Neighborhood Hits	479	Shared Neighborhood Hits	61
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

GOGA4_HUMAN
NC score	0.064624 (rank : 225)	θ value	0.0113563 (rank : 95)
Query Neighborhood Hits	239	Target Neighborhood Hits	2034	Shared Neighborhood Hits	95
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

SH3G3_HUMAN
NC score	0.064500 (rank : 226)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	239	Target Neighborhood Hits	222	Shared Neighborhood Hits	20
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SRGP2_MOUSE
NC score	0.064073 (rank : 227)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	239	Target Neighborhood Hits	324	Shared Neighborhood Hits	43
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRGP2_HUMAN
NC score	0.063993 (rank : 228)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	239	Target Neighborhood Hits	331	Shared Neighborhood Hits	42
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

RBP1_HUMAN
NC score	0.063941 (rank : 229)	θ value	0.813845 (rank : 131)
Query Neighborhood Hits	239	Target Neighborhood Hits	521	Shared Neighborhood Hits	62
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RBP1_MOUSE
NC score	0.063701 (rank : 230)	θ value	1.06291 (rank : 138)
Query Neighborhood Hits	239	Target Neighborhood Hits	493	Shared Neighborhood Hits	59
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

SH3G2_HUMAN
NC score	0.063605 (rank : 231)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	239	Target Neighborhood Hits	324	Shared Neighborhood Hits	31
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

PKHB1_HUMAN
NC score	0.063315 (rank : 232)	θ value	1.81305 (rank : 151)
Query Neighborhood Hits	239	Target Neighborhood Hits	46	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

SHAN2_MOUSE
NC score	0.063217 (rank : 233)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	239	Target Neighborhood Hits	446	Shared Neighborhood Hits	29
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

PLCG2_HUMAN
NC score	0.062580 (rank : 234)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	239	Target Neighborhood Hits	280	Shared Neighborhood Hits	20
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

CEND2_HUMAN
NC score	0.062489 (rank : 235)	θ value	0.47712 (rank : 120)
Query Neighborhood Hits	239	Target Neighborhood Hits	166	Shared Neighborhood Hits	46
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

SH3G1_MOUSE
NC score	0.062148 (rank : 236)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	239	Target Neighborhood Hits	291	Shared Neighborhood Hits	27
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

TARA_MOUSE
NC score	0.062027 (rank : 237)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	239	Target Neighborhood Hits	1133	Shared Neighborhood Hits	104
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

SH3G2_MOUSE
NC score	0.061995 (rank : 238)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	239	Target Neighborhood Hits	319	Shared Neighborhood Hits	29
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

GOGA4_MOUSE
NC score	0.061966 (rank : 239)	θ value	0.00509761 (rank : 89)
Query Neighborhood Hits	239	Target Neighborhood Hits	1939	Shared Neighborhood Hits	89
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

CENPF_HUMAN
NC score	0.061921 (rank : 240)	θ value	0.125558 (rank : 107)
Query Neighborhood Hits	239	Target Neighborhood Hits	1932	Shared Neighborhood Hits	99
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

PSD4_MOUSE
NC score	0.061900 (rank : 241)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	239	Target Neighborhood Hits	78	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

CCD96_MOUSE
NC score	0.061876 (rank : 242)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	239	Target Neighborhood Hits	704	Shared Neighborhood Hits	70
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

IQEC3_HUMAN
NC score	0.061602 (rank : 243)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	239	Target Neighborhood Hits	125	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

OSB10_HUMAN
NC score	0.061391 (rank : 244)	θ value	0.813845 (rank : 130)
Query Neighborhood Hits	239	Target Neighborhood Hits	55	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BXB5, Q9BTU5	Gene names	OSBPL10, ORP10, OSBP9
Domain Architecture
Description	Oxysterol-binding protein-related protein 10 (OSBP-related protein 10) (ORP-10).

K1914_MOUSE
NC score	0.061288 (rank : 245)	θ value	0.62314 (rank : 126)
Query Neighborhood Hits	239	Target Neighborhood Hits	216	Shared Neighborhood Hits	38
SwissProt Accessions	Q5DTU0, Q8BID1, Q8K2G0	Gene names	Kiaa1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

ZFY19_HUMAN
NC score	0.060766 (rank : 246)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	239	Target Neighborhood Hits	206	Shared Neighborhood Hits	18
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

PHLB2_MOUSE
NC score	0.060728 (rank : 247)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	239	Target Neighborhood Hits	1016	Shared Neighborhood Hits	102
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

OSTF1_HUMAN
NC score	0.060527 (rank : 248)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	239	Target Neighborhood Hits	466	Shared Neighborhood Hits	25
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

P85B_HUMAN
NC score	0.060470 (rank : 249)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	239	Target Neighborhood Hits	543	Shared Neighborhood Hits	62
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85A_MOUSE
NC score	0.060247 (rank : 250)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	239	Target Neighborhood Hits	435	Shared Neighborhood Hits	56
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

OSTF1_MOUSE
NC score	0.059825 (rank : 251)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	239	Target Neighborhood Hits	467	Shared Neighborhood Hits	25
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

BI2L1_MOUSE
NC score	0.059678 (rank : 252)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	239	Target Neighborhood Hits	197	Shared Neighborhood Hits	33
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

P85B_MOUSE
NC score	0.059654 (rank : 253)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	239	Target Neighborhood Hits	519	Shared Neighborhood Hits	63
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

DBNL_HUMAN
NC score	0.059548 (rank : 254)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	239	Target Neighborhood Hits	244	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

PSD4_HUMAN
NC score	0.059447 (rank : 255)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	239	Target Neighborhood Hits	178	Shared Neighborhood Hits	22
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

PIBF1_HUMAN
NC score	0.059167 (rank : 256)	θ value	1.06291 (rank : 136)
Query Neighborhood Hits	239	Target Neighborhood Hits	1041	Shared Neighborhood Hits	80
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

LASP1_HUMAN
NC score	0.058536 (rank : 257)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	239	Target Neighborhood Hits	293	Shared Neighborhood Hits	23
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

CHIN_MOUSE
NC score	0.058533 (rank : 258)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	239	Target Neighborhood Hits	229	Shared Neighborhood Hits	19
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_HUMAN
NC score	0.058411 (rank : 259)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	239	Target Neighborhood Hits	227	Shared Neighborhood Hits	19
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

PHLB2_HUMAN
NC score	0.058364 (rank : 260)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	239	Target Neighborhood Hits	964	Shared Neighborhood Hits	101
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

IQEC3_MOUSE
NC score	0.058348 (rank : 261)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	239	Target Neighborhood Hits	274	Shared Neighborhood Hits	23
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

EP15_MOUSE
NC score	0.058166 (rank : 262)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	239	Target Neighborhood Hits	820	Shared Neighborhood Hits	66
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

LMO7_HUMAN
NC score	0.058109 (rank : 263)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	239	Target Neighborhood Hits	507	Shared Neighborhood Hits	52
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

REPS1_MOUSE
NC score	0.057842 (rank : 264)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	239	Target Neighborhood Hits	204	Shared Neighborhood Hits	21
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

KTN1_HUMAN
NC score	0.057835 (rank : 265)	θ value	0.125558 (rank : 109)
Query Neighborhood Hits	239	Target Neighborhood Hits	1197	Shared Neighborhood Hits	85
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

ZFY19_MOUSE
NC score	0.057163 (rank : 266)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	239	Target Neighborhood Hits	143	Shared Neighborhood Hits	18
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

CP250_HUMAN
NC score	0.057055 (rank : 267)	θ value	0.279714 (rank : 115)
Query Neighborhood Hits	239	Target Neighborhood Hits	1805	Shared Neighborhood Hits	91
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

GBF1_HUMAN
NC score	0.056993 (rank : 268)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	239	Target Neighborhood Hits	142	Shared Neighborhood Hits	13
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

LASP1_MOUSE
NC score	0.056965 (rank : 269)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	239	Target Neighborhood Hits	297	Shared Neighborhood Hits	23
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

GOGB1_HUMAN
NC score	0.056744 (rank : 270)	θ value	2.36792 (rank : 161)
Query Neighborhood Hits	239	Target Neighborhood Hits	2297	Shared Neighborhood Hits	115
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

BICD1_MOUSE
NC score	0.056610 (rank : 271)	θ value	1.38821 (rank : 140)
Query Neighborhood Hits	239	Target Neighborhood Hits	837	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BR07, O55206, Q8BQ18, Q8BRR8, Q8C4D3, Q8CAK6, Q8R2J4, Q8R2J5, Q8R2J6, Q91YP7	Gene names	Bicd1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

PACN3_MOUSE
NC score	0.056593 (rank : 272)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	239	Target Neighborhood Hits	380	Shared Neighborhood Hits	45
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

CT152_MOUSE
NC score	0.056553 (rank : 273)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	239	Target Neighborhood Hits	38	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

CP250_MOUSE
NC score	0.056545 (rank : 274)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	239	Target Neighborhood Hits	1583	Shared Neighborhood Hits	90
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

RIMB1_MOUSE
NC score	0.056273 (rank : 275)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	239	Target Neighborhood Hits	1376	Shared Neighborhood Hits	87
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

CJ118_MOUSE
NC score	0.056167 (rank : 276)	θ value	0.0563607 (rank : 99)
Query Neighborhood Hits	239	Target Neighborhood Hits	1132	Shared Neighborhood Hits	77
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

CHIO_MOUSE
NC score	0.056093 (rank : 277)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	239	Target Neighborhood Hits	130	Shared Neighborhood Hits	17
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

BIG2_HUMAN
NC score	0.056023 (rank : 278)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	239	Target Neighborhood Hits	66	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

DBNL_MOUSE
NC score	0.055875 (rank : 279)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	239	Target Neighborhood Hits	306	Shared Neighborhood Hits	24
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

CENA1_HUMAN
NC score	0.055646 (rank : 280)	θ value	1.06291 (rank : 132)
Query Neighborhood Hits	239	Target Neighborhood Hits	87	Shared Neighborhood Hits	32
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

SPTA2_HUMAN
NC score	0.055535 (rank : 281)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	239	Target Neighborhood Hits	888	Shared Neighborhood Hits	79
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

AHI1_HUMAN
NC score	0.055518 (rank : 282)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	239	Target Neighborhood Hits	537	Shared Neighborhood Hits	28
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

CHIO_HUMAN
NC score	0.055204 (rank : 283)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	239	Target Neighborhood Hits	220	Shared Neighborhood Hits	19
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

OSBP1_HUMAN
NC score	0.054756 (rank : 284)	θ value	4.03905 (rank : 183)
Query Neighborhood Hits	239	Target Neighborhood Hits	180	Shared Neighborhood Hits	48
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

BIG1_HUMAN
NC score	0.054737 (rank : 285)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	239	Target Neighborhood Hits	76	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

CEP63_HUMAN
NC score	0.054587 (rank : 286)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	239	Target Neighborhood Hits	1005	Shared Neighborhood Hits	75
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

HMMR_MOUSE
NC score	0.054562 (rank : 287)	θ value	8.99809 (rank : 224)
Query Neighborhood Hits	239	Target Neighborhood Hits	1178	Shared Neighborhood Hits	82
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

PCNT_HUMAN
NC score	0.054543 (rank : 288)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	239	Target Neighborhood Hits	1551	Shared Neighborhood Hits	93
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

ZFYV1_HUMAN
NC score	0.054509 (rank : 289)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	239	Target Neighborhood Hits	166	Shared Neighborhood Hits	20
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

AKAP9_HUMAN
NC score	0.054460 (rank : 290)	θ value	1.81305 (rank : 146)
Query Neighborhood Hits	239	Target Neighborhood Hits	1710	Shared Neighborhood Hits	94
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

PACN3_HUMAN
NC score	0.054351 (rank : 291)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	239	Target Neighborhood Hits	385	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

REPS2_HUMAN
NC score	0.054220 (rank : 292)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	239	Target Neighborhood Hits	131	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

NEMO_MOUSE
NC score	0.054193 (rank : 293)	θ value	0.0736092 (rank : 101)
Query Neighborhood Hits	239	Target Neighborhood Hits	658	Shared Neighborhood Hits	60
SwissProt Accessions	O88522	Gene names	Ikbkg, Nemo
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3).

AHI1_MOUSE
NC score	0.054043 (rank : 294)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	239	Target Neighborhood Hits	496	Shared Neighborhood Hits	26
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

REPS2_MOUSE
NC score	0.054010 (rank : 295)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	239	Target Neighborhood Hits	102	Shared Neighborhood Hits	7
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

BICD2_MOUSE
NC score	0.053804 (rank : 296)	θ value	4.03905 (rank : 173)
Query Neighborhood Hits	239	Target Neighborhood Hits	864	Shared Neighborhood Hits	75
SwissProt Accessions	Q921C5, Q80TU1, Q8BTE3, Q9DCL3	Gene names	Bicd2, Kiaa0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

GOGA5_MOUSE
NC score	0.053682 (rank : 297)	θ value	2.36792 (rank : 160)
Query Neighborhood Hits	239	Target Neighborhood Hits	1434	Shared Neighborhood Hits	92
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

RFIP3_HUMAN
NC score	0.053406 (rank : 298)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	239	Target Neighborhood Hits	1055	Shared Neighborhood Hits	84
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

JIP3_HUMAN
NC score	0.053377 (rank : 299)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	239	Target Neighborhood Hits	1039	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

ZFYV1_MOUSE
NC score	0.053255 (rank : 300)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	239	Target Neighborhood Hits	153	Shared Neighborhood Hits	19
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

CEP55_MOUSE
NC score	0.053055 (rank : 301)	θ value	6.88961 (rank : 209)
Query Neighborhood Hits	239	Target Neighborhood Hits	693	Shared Neighborhood Hits	70
SwissProt Accessions	Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8	Gene names	Cep55
Domain Architecture	No domain graphic available
Description	Centrosome protein 55.

TPR_HUMAN
NC score	0.053017 (rank : 302)	θ value	6.88961 (rank : 218)
Query Neighborhood Hits	239	Target Neighborhood Hits	1921	Shared Neighborhood Hits	98
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

TRIPB_HUMAN
NC score	0.053012 (rank : 303)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	239	Target Neighborhood Hits	1587	Shared Neighborhood Hits	93
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

SAS6_MOUSE
NC score	0.052941 (rank : 304)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	239	Target Neighborhood Hits	931	Shared Neighborhood Hits	76
SwissProt Accessions	Q80UK7, Q9CYT4	Gene names	Sass6, Sas6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog.

MD1L1_MOUSE
NC score	0.052828 (rank : 305)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	239	Target Neighborhood Hits	1001	Shared Neighborhood Hits	76
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

MRIP_HUMAN
NC score	0.052813 (rank : 306)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	239	Target Neighborhood Hits	578	Shared Neighborhood Hits	97
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

BICD1_HUMAN
NC score	0.052775 (rank : 307)	θ value	2.36792 (rank : 156)
Query Neighborhood Hits	239	Target Neighborhood Hits	844	Shared Neighborhood Hits	69
SwissProt Accessions	Q96G01, O43892, O43893	Gene names	BICD1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

NPHP1_MOUSE
NC score	0.052708 (rank : 308)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	239	Target Neighborhood Hits	267	Shared Neighborhood Hits	30
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

CCD13_HUMAN
NC score	0.052629 (rank : 309)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	239	Target Neighborhood Hits	721	Shared Neighborhood Hits	68
SwissProt Accessions	Q8IYE1	Gene names	CCDC13
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 13.

REST_HUMAN
NC score	0.052516 (rank : 310)	θ value	5.27518 (rank : 198)
Query Neighborhood Hits	239	Target Neighborhood Hits	1605	Shared Neighborhood Hits	91
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

PEX13_MOUSE
NC score	0.052414 (rank : 311)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	239	Target Neighborhood Hits	126	Shared Neighborhood Hits	16
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PHLB1_HUMAN
NC score	0.052370 (rank : 312)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	239	Target Neighborhood Hits	1038	Shared Neighborhood Hits	96
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PACN2_MOUSE
NC score	0.052230 (rank : 313)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	239	Target Neighborhood Hits	382	Shared Neighborhood Hits	43
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

BICD2_HUMAN
NC score	0.052125 (rank : 314)	θ value	6.88961 (rank : 206)
Query Neighborhood Hits	239	Target Neighborhood Hits	856	Shared Neighborhood Hits	72
SwissProt Accessions	Q8TD16, O75181, Q5TBQ2, Q5TBQ3, Q96LH2, Q9BT84, Q9H561	Gene names	BICD2, KIAA0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

CCD46_MOUSE
NC score	0.052102 (rank : 315)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	239	Target Neighborhood Hits	1405	Shared Neighborhood Hits	87
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

GCC2_MOUSE
NC score	0.051884 (rank : 316)	θ value	4.03905 (rank : 178)
Query Neighborhood Hits	239	Target Neighborhood Hits	1619	Shared Neighborhood Hits	86
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

RIMB1_HUMAN
NC score	0.051866 (rank : 317)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	239	Target Neighborhood Hits	1479	Shared Neighborhood Hits	86
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

CE290_HUMAN
NC score	0.051812 (rank : 318)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	239	Target Neighborhood Hits	1553	Shared Neighborhood Hits	86
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

CCD46_HUMAN
NC score	0.051718 (rank : 319)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	239	Target Neighborhood Hits	1430	Shared Neighborhood Hits	84
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

PACN2_HUMAN
NC score	0.051617 (rank : 320)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	239	Target Neighborhood Hits	339	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

TAXB1_HUMAN
NC score	0.051564 (rank : 321)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	239	Target Neighborhood Hits	829	Shared Neighborhood Hits	70
SwissProt Accessions	Q86VP1, O60398, O95770, Q13311, Q9BQG5, Q9UI88	Gene names	TAX1BP1, T6BP
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 (TRAF6-binding protein).

CCD41_HUMAN
NC score	0.051528 (rank : 322)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	239	Target Neighborhood Hits	1139	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

PEX13_HUMAN
NC score	0.051409 (rank : 323)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	239	Target Neighborhood Hits	128	Shared Neighborhood Hits	16
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

IFT81_MOUSE
NC score	0.051388 (rank : 324)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	239	Target Neighborhood Hits	959	Shared Neighborhood Hits	72
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

SPTB2_HUMAN
NC score	0.051321 (rank : 325)	θ value	2.36792 (rank : 164)
Query Neighborhood Hits	239	Target Neighborhood Hits	748	Shared Neighborhood Hits	87
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

TACC2_MOUSE
NC score	0.051289 (rank : 326)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	239	Target Neighborhood Hits	774	Shared Neighborhood Hits	68
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

FBX8_MOUSE
NC score	0.051286 (rank : 327)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	239	Target Neighborhood Hits	45	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QZN3	Gene names	Fbxo8, Fbx8
Domain Architecture
Description	F-box only protein 8.

FLIP1_HUMAN
NC score	0.051181 (rank : 328)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	239	Target Neighborhood Hits	1405	Shared Neighborhood Hits	89
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

FBX8_HUMAN
NC score	0.051116 (rank : 329)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	239	Target Neighborhood Hits	44	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NRD0, Q6UWN4, Q9NRP5, Q9UKC4	Gene names	FBXO8, FBS, FBX8
Domain Architecture
Description	F-box only protein 8 (F-box/SEC7 protein FBS).

NOXO1_HUMAN
NC score	0.051087 (rank : 330)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	239	Target Neighborhood Hits	100	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

CYLN2_HUMAN
NC score	0.051081 (rank : 331)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	239	Target Neighborhood Hits	1004	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UDT6, O14527, O43611	Gene names	CYLN2, KIAA0291, WBSCR4, WSCR4
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115) (Williams-Beuren syndrome chromosome region 4 protein).

CI093_HUMAN
NC score	0.051017 (rank : 332)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	239	Target Neighborhood Hits	1088	Shared Neighborhood Hits	79
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

GOGA5_HUMAN
NC score	0.050859 (rank : 333)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	239	Target Neighborhood Hits	1168	Shared Neighborhood Hits	85
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

SYCP1_MOUSE
NC score	0.050813 (rank : 334)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	239	Target Neighborhood Hits	1456	Shared Neighborhood Hits	93
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

CK5P2_MOUSE
NC score	0.050721 (rank : 335)	θ value	4.03905 (rank : 175)
Query Neighborhood Hits	239	Target Neighborhood Hits	1151	Shared Neighborhood Hits	80
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

REPS1_HUMAN
NC score	0.050622 (rank : 336)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	239	Target Neighborhood Hits	205	Shared Neighborhood Hits	14
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

CCD21_MOUSE
NC score	0.050602 (rank : 337)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	239	Target Neighborhood Hits	1135	Shared Neighborhood Hits	84
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

MRIP_MOUSE
NC score	0.050552 (rank : 338)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	239	Target Neighborhood Hits	569	Shared Neighborhood Hits	95
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

RAD50_MOUSE
NC score	0.050511 (rank : 339)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	239	Target Neighborhood Hits	1366	Shared Neighborhood Hits	85
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

CP135_MOUSE
NC score	0.050475 (rank : 340)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	239	Target Neighborhood Hits	1278	Shared Neighborhood Hits	82
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

CE152_HUMAN
NC score	0.050455 (rank : 341)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	239	Target Neighborhood Hits	976	Shared Neighborhood Hits	76
SwissProt Accessions	O94986, Q6NTA0	Gene names	CEP152, KIAA0912
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 152 kDa (Cep152 protein).

SH2D3_MOUSE
NC score	0.050453 (rank : 342)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	239	Target Neighborhood Hits	174	Shared Neighborhood Hits	20
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

NEBU_HUMAN
NC score	0.050432 (rank : 343)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	239	Target Neighborhood Hits	420	Shared Neighborhood Hits	37
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

RAD50_HUMAN
NC score	0.050404 (rank : 344)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	239	Target Neighborhood Hits	1317	Shared Neighborhood Hits	86
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

SPTA1_MOUSE
NC score	0.050403 (rank : 345)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	239	Target Neighborhood Hits	675	Shared Neighborhood Hits	72
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

CENB2_HUMAN
NC score	0.050388 (rank : 346)	θ value	4.03905 (rank : 174)
Query Neighborhood Hits	239	Target Neighborhood Hits	425	Shared Neighborhood Hits	56
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CASP_HUMAN
NC score	0.050388 (rank : 347)	θ value	6.88961 (rank : 207)
Query Neighborhood Hits	239	Target Neighborhood Hits	1131	Shared Neighborhood Hits	76
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CASP_MOUSE
NC score	0.050312 (rank : 348)	θ value	6.88961 (rank : 208)
Query Neighborhood Hits	239	Target Neighborhood Hits	1152	Shared Neighborhood Hits	77
SwissProt Accessions	P70403, Q7TQJ4, Q91WN6	Gene names	Cutl1
Domain Architecture	No domain graphic available
Description	Protein CASP.

IFT74_HUMAN
NC score	0.050303 (rank : 349)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	239	Target Neighborhood Hits	949	Shared Neighborhood Hits	75
SwissProt Accessions	Q96LB3, Q6PGQ8, Q9H643, Q9H8G7	Gene names	IFT74, CCDC2, CMG1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

ALS2_MOUSE
NC score	0.050288 (rank : 350)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	239	Target Neighborhood Hits	111	Shared Neighborhood Hits	22
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

IQEC2_HUMAN
NC score	0.050232 (rank : 351)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	239	Target Neighborhood Hits	403	Shared Neighborhood Hits	29
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

OPTN_MOUSE
NC score	0.050232 (rank : 352)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	239	Target Neighborhood Hits	1120	Shared Neighborhood Hits	79
SwissProt Accessions	Q8K3K8	Gene names	Optn
Domain Architecture	No domain graphic available
Description	Optineurin.

HOOK3_MOUSE
NC score	0.050217 (rank : 353)	θ value	8.99809 (rank : 225)
Query Neighborhood Hits	239	Target Neighborhood Hits	1007	Shared Neighborhood Hits	81
SwissProt Accessions	Q8BUK6, Q8BV48, Q8BW57, Q8BY41	Gene names	Hook3
Domain Architecture
Description	Hook homolog 3.

IQEC1_HUMAN
NC score	0.050184 (rank : 354)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	239	Target Neighborhood Hits	76	Shared Neighborhood Hits	15
SwissProt Accessions	Q6DN90, O94863, Q96D85	Gene names	IQSEC1, ARFGEP100, BRAG2, KIAA0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein).

RABE1_HUMAN
NC score	0.050103 (rank : 355)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	239	Target Neighborhood Hits	1104	Shared Neighborhood Hits	73
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

TUFT1_MOUSE
NC score	0.050035 (rank : 356)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	239	Target Neighborhood Hits	732	Shared Neighborhood Hits	67
SwissProt Accessions	O08970	Gene names	Tuft1
Domain Architecture
Description	Tuftelin.

NEMO_HUMAN
NC score	0.050011 (rank : 357)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	239	Target Neighborhood Hits	820	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y6K9	Gene names	IKBKG, FIP3, NEMO
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (FIP-3).

PKHB1_MOUSE
NC score	0.049915 (rank : 358)	θ value	6.88961 (rank : 215)
Query Neighborhood Hits	239	Target Neighborhood Hits	47	Shared Neighborhood Hits	24
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

REST_MOUSE
NC score	0.049774 (rank : 359)	θ value	1.38821 (rank : 145)
Query Neighborhood Hits	239	Target Neighborhood Hits	1506	Shared Neighborhood Hits	87
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

ODO1_MOUSE
NC score	0.049597 (rank : 360)	θ value	0.279714 (rank : 116)
Query Neighborhood Hits	239	Target Neighborhood Hits	21	Shared Neighborhood Hits	5
SwissProt Accessions	Q60597, Q80Y57, Q8K2Z3	Gene names	Ogdh
Domain Architecture
Description	2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase).

BPAEA_MOUSE
NC score	0.049098 (rank : 361)	θ value	8.99809 (rank : 220)
Query Neighborhood Hits	239	Target Neighborhood Hits	1480	Shared Neighborhood Hits	84
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

GOGA2_MOUSE
NC score	0.048286 (rank : 362)	θ value	4.03905 (rank : 179)
Query Neighborhood Hits	239	Target Neighborhood Hits	944	Shared Neighborhood Hits	75
SwissProt Accessions	Q921M4	Gene names	Golga2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130).

ODO1_HUMAN
NC score	0.048094 (rank : 363)	θ value	0.365318 (rank : 119)
Query Neighborhood Hits	239	Target Neighborhood Hits	18	Shared Neighborhood Hits	5
SwissProt Accessions	Q02218	Gene names	OGDH
Domain Architecture
Description	2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase).

SYCP1_HUMAN
NC score	0.048071 (rank : 364)	θ value	6.88961 (rank : 216)
Query Neighborhood Hits	239	Target Neighborhood Hits	1313	Shared Neighborhood Hits	83
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

CENPE_HUMAN
NC score	0.047051 (rank : 365)	θ value	8.99809 (rank : 221)
Query Neighborhood Hits	239	Target Neighborhood Hits	2060	Shared Neighborhood Hits	102
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

MYH6_MOUSE
NC score	0.047043 (rank : 366)	θ value	0.47712 (rank : 121)
Query Neighborhood Hits	239	Target Neighborhood Hits	1501	Shared Neighborhood Hits	88
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH7_HUMAN
NC score	0.046632 (rank : 367)	θ value	0.62314 (rank : 128)
Query Neighborhood Hits	239	Target Neighborhood Hits	1559	Shared Neighborhood Hits	92
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

CENA2_HUMAN
NC score	0.046328 (rank : 368)	θ value	1.81305 (rank : 149)
Query Neighborhood Hits	239	Target Neighborhood Hits	83	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

CUTL1_MOUSE
NC score	0.045967 (rank : 369)	θ value	6.88961 (rank : 211)
Query Neighborhood Hits	239	Target Neighborhood Hits	1620	Shared Neighborhood Hits	80
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

MYH6_HUMAN
NC score	0.045568 (rank : 370)	θ value	0.62314 (rank : 127)
Query Neighborhood Hits	239	Target Neighborhood Hits	1426	Shared Neighborhood Hits	85
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

RPGR1_HUMAN
NC score	0.045450 (rank : 371)	θ value	8.99809 (rank : 234)
Query Neighborhood Hits	239	Target Neighborhood Hits	578	Shared Neighborhood Hits	68
SwissProt Accessions	Q96KN7, Q7Z2W6, Q8IXV5, Q96QA8, Q9HB94, Q9HB95, Q9HBK6, Q9NR40	Gene names	RPGRIP1
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

BPAEA_HUMAN
NC score	0.045401 (rank : 372)	θ value	0.279714 (rank : 114)
Query Neighborhood Hits	239	Target Neighborhood Hits	1369	Shared Neighborhood Hits	82
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

CUTL1_HUMAN
NC score	0.045387 (rank : 373)	θ value	6.88961 (rank : 210)
Query Neighborhood Hits	239	Target Neighborhood Hits	1574	Shared Neighborhood Hits	83
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

NUF2_HUMAN
NC score	0.043963 (rank : 374)	θ value	8.99809 (rank : 230)
Query Neighborhood Hits	239	Target Neighborhood Hits	661	Shared Neighborhood Hits	63
SwissProt Accessions	Q9BZD4, Q8WU69, Q96HJ4, Q96Q78	Gene names	CDCA1, NUF2, NUF2R
Domain Architecture	No domain graphic available
Description	Kinetochore protein Nuf2 (hNuf2) (hNuf2R) (hsNuf2) (Cell division cycle-associated protein 1).

MYH3_HUMAN
NC score	0.043909 (rank : 375)	θ value	4.03905 (rank : 181)
Query Neighborhood Hits	239	Target Neighborhood Hits	1660	Shared Neighborhood Hits	91
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

MYH1_HUMAN
NC score	0.043810 (rank : 376)	θ value	5.27518 (rank : 194)
Query Neighborhood Hits	239	Target Neighborhood Hits	1478	Shared Neighborhood Hits	88
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

UACA_MOUSE
NC score	0.043376 (rank : 377)	θ value	0.21417 (rank : 113)
Query Neighborhood Hits	239	Target Neighborhood Hits	1620	Shared Neighborhood Hits	81
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

MYH1_MOUSE
NC score	0.042628 (rank : 378)	θ value	5.27518 (rank : 195)
Query Neighborhood Hits	239	Target Neighborhood Hits	1461	Shared Neighborhood Hits	87
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

AN30A_HUMAN
NC score	0.041837 (rank : 379)	θ value	0.813845 (rank : 129)
Query Neighborhood Hits	239	Target Neighborhood Hits	1119	Shared Neighborhood Hits	73
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

TACC3_HUMAN
NC score	0.041588 (rank : 380)	θ value	0.47712 (rank : 123)
Query Neighborhood Hits	239	Target Neighborhood Hits	779	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

MYH10_HUMAN
NC score	0.041306 (rank : 381)	θ value	8.99809 (rank : 228)
Query Neighborhood Hits	239	Target Neighborhood Hits	1620	Shared Neighborhood Hits	85
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH14_HUMAN
NC score	0.041118 (rank : 382)	θ value	0.365318 (rank : 118)
Query Neighborhood Hits	239	Target Neighborhood Hits	995	Shared Neighborhood Hits	72
SwissProt Accessions	Q7Z406, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882	Gene names	MYH14, KIAA2034
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

UACA_HUMAN
NC score	0.039571 (rank : 383)	θ value	5.27518 (rank : 203)
Query Neighborhood Hits	239	Target Neighborhood Hits	1622	Shared Neighborhood Hits	79
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

RHG06_MOUSE
NC score	0.037431 (rank : 384)	θ value	5.27518 (rank : 199)
Query Neighborhood Hits	239	Target Neighborhood Hits	105	Shared Neighborhood Hits	9
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

ANR18_HUMAN
NC score	0.037009 (rank : 385)	θ value	2.36792 (rank : 155)
Query Neighborhood Hits	239	Target Neighborhood Hits	1106	Shared Neighborhood Hits	79
SwissProt Accessions	Q8IVF6, Q7Z468	Gene names	ANKRD18A, KIAA2015
Domain Architecture
Description	Ankyrin repeat domain-containing protein 18A.

KIF5C_MOUSE
NC score	0.036425 (rank : 386)	θ value	8.99809 (rank : 226)
Query Neighborhood Hits	239	Target Neighborhood Hits	1040	Shared Neighborhood Hits	79
SwissProt Accessions	P28738, Q9Z2F8	Gene names	Kif5c, Nkhc2
Domain Architecture
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

STAP1_MOUSE
NC score	0.032465 (rank : 387)	θ value	1.81305 (rank : 152)
Query Neighborhood Hits	239	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JM90, Q3TRM1, Q6PES6	Gene names	Stap1
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 1 (STAP-1) (Stem cell adaptor protein 1).

WRB_MOUSE
NC score	0.032150 (rank : 388)	θ value	1.81305 (rank : 154)
Query Neighborhood Hits	239	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K0D7, Q3TA55, Q9D1W0	Gene names	Wrb
Domain Architecture	No domain graphic available
Description	Tryptophan-rich protein.

WRB_HUMAN
NC score	0.032094 (rank : 389)	θ value	1.81305 (rank : 153)
Query Neighborhood Hits	239	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	O00258, O60740	Gene names	WRB, CHD5
Domain Architecture
Description	Tryptophan-rich protein (Congenital heart disease 5 protein).

SPNXE_HUMAN
NC score	0.030969 (rank : 390)	θ value	1.06291 (rank : 139)
Query Neighborhood Hits	239	Target Neighborhood Hits	6	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TAD1, Q9BS24	Gene names	SPANXE
Domain Architecture	No domain graphic available
Description	Sperm protein associated with the nucleus on the X chromosome E (Nuclear-associated protein SPAN-Xe).

TXLNB_MOUSE
NC score	0.030076 (rank : 391)	θ value	8.99809 (rank : 239)
Query Neighborhood Hits	239	Target Neighborhood Hits	640	Shared Neighborhood Hits	59
SwissProt Accessions	Q8VBT1, Q3UVB8, Q8BUK2	Gene names	Txlnb, Mdp77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77).

CENA2_MOUSE
NC score	0.029107 (rank : 392)	θ value	5.27518 (rank : 187)
Query Neighborhood Hits	239	Target Neighborhood Hits	68	Shared Neighborhood Hits	20
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

LRCH1_HUMAN
NC score	0.028968 (rank : 393)	θ value	1.38821 (rank : 144)
Query Neighborhood Hits	239	Target Neighborhood Hits	266	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y2L9, Q7Z5F6, Q7Z5F7	Gene names	LRCH1, CHDC1, KIAA1016
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1) (Neuronal protein 81) (NP81).

LRCH1_MOUSE
NC score	0.028893 (rank : 394)	θ value	1.06291 (rank : 134)
Query Neighborhood Hits	239	Target Neighborhood Hits	264	Shared Neighborhood Hits	15
SwissProt Accessions	P62046	Gene names	Lrch1, Chdc1, Kiaa1016
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1).

LIN1_HUMAN
NC score	0.027859 (rank : 395)	θ value	6.88961 (rank : 214)
Query Neighborhood Hits	239	Target Neighborhood Hits	187	Shared Neighborhood Hits	28
SwissProt Accessions	P08547	Gene names
Domain Architecture	No domain graphic available
Description	LINE-1 reverse transcriptase homolog.

KIF3A_MOUSE
NC score	0.027351 (rank : 396)	θ value	3.0926 (rank : 168)
Query Neighborhood Hits	239	Target Neighborhood Hits	715	Shared Neighborhood Hits	69
SwissProt Accessions	P28741	Gene names	Kif3a, Kif3
Domain Architecture
Description	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A).

KIF3A_HUMAN
NC score	0.026499 (rank : 397)	θ value	3.0926 (rank : 167)
Query Neighborhood Hits	239	Target Neighborhood Hits	704	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Y496, Q86XE9, Q9Y6V4	Gene names	KIF3A, KIF3
Domain Architecture
Description	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A).

KIF3C_HUMAN
NC score	0.024839 (rank : 398)	θ value	1.06291 (rank : 133)
Query Neighborhood Hits	239	Target Neighborhood Hits	478	Shared Neighborhood Hits	61
SwissProt Accessions	O14782, O43544	Gene names	KIF3C
Domain Architecture
Description	Kinesin-like protein KIF3C.

SPNXD_HUMAN
NC score	0.024465 (rank : 399)	θ value	4.03905 (rank : 185)
Query Neighborhood Hits	239	Target Neighborhood Hits	6	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BXN6	Gene names	SPANXD
Domain Architecture	No domain graphic available
Description	Sperm protein associated with the nucleus on the X chromosome D (Nuclear-associated protein SPAN-Xd).

SPNXA_HUMAN
NC score	0.023980 (rank : 400)	θ value	4.03905 (rank : 184)
Query Neighborhood Hits	239	Target Neighborhood Hits	7	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NS26	Gene names	SPANXA1, SPANXA
Domain Architecture	No domain graphic available
Description	Sperm protein associated with the nucleus on the X chromosome A (Nuclear-associated protein SPAN-Xa) (SPAN-X).

CENPQ_MOUSE
NC score	0.023572 (rank : 401)	θ value	8.99809 (rank : 222)
Query Neighborhood Hits	239	Target Neighborhood Hits	160	Shared Neighborhood Hits	27
SwissProt Accessions	Q9CPQ5, Q8C2G4, Q8VEF8, Q9CX70	Gene names	Cenpq
Domain Architecture	No domain graphic available
Description	Centromere protein Q (CENP-Q).

SRRM1_HUMAN
NC score	0.023459 (rank : 402)	θ value	5.27518 (rank : 201)
Query Neighborhood Hits	239	Target Neighborhood Hits	690	Shared Neighborhood Hits	24
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

ANK2_HUMAN
NC score	0.021532 (rank : 403)	θ value	0.62314 (rank : 124)
Query Neighborhood Hits	239	Target Neighborhood Hits	1615	Shared Neighborhood Hits	63
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

LAMB1_HUMAN
NC score	0.019485 (rank : 404)	θ value	3.0926 (rank : 169)
Query Neighborhood Hits	239	Target Neighborhood Hits	1018	Shared Neighborhood Hits	68
SwissProt Accessions	P07942	Gene names	LAMB1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

KIF1B_HUMAN
NC score	0.019106 (rank : 405)	θ value	0.125558 (rank : 108)
Query Neighborhood Hits	239	Target Neighborhood Hits	178	Shared Neighborhood Hits	23
SwissProt Accessions	O60333, Q96Q94, Q9BV80, Q9P280	Gene names	KIF1B, KIAA0591, KIAA1448
Domain Architecture
Description	Kinesin-like protein KIF1B (Klp).

DJBP_HUMAN
NC score	0.016483 (rank : 406)	θ value	1.38821 (rank : 142)
Query Neighborhood Hits	239	Target Neighborhood Hits	156	Shared Neighborhood Hits	3
SwissProt Accessions	Q5THR3, Q5U5T6, Q9BY88, Q9H5C4, Q9NSF5	Gene names	DJBP, KIAA1672
Domain Architecture	No domain graphic available
Description	DJ-1-binding protein (CAP-binding protein complex-interacting protein 1).

LAMB1_MOUSE
NC score	0.015428 (rank : 407)	θ value	5.27518 (rank : 192)
Query Neighborhood Hits	239	Target Neighborhood Hits	919	Shared Neighborhood Hits	65
SwissProt Accessions	P02469	Gene names	Lamb1-1, Lamb-1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

EPN2_HUMAN
NC score	0.015255 (rank : 408)	θ value	2.36792 (rank : 159)
Query Neighborhood Hits	239	Target Neighborhood Hits	156	Shared Neighborhood Hits	9
SwissProt Accessions	O95208, O95207, Q9H7Z2, Q9UPT7	Gene names	EPN2, KIAA1065
Domain Architecture
Description	Epsin-2 (EPS-15-interacting protein 2).

PDE1B_HUMAN
NC score	0.014509 (rank : 409)	θ value	1.06291 (rank : 135)
Query Neighborhood Hits	239	Target Neighborhood Hits	50	Shared Neighborhood Hits	5
SwissProt Accessions	Q01064, Q92825	Gene names	PDE1B, PDE1B1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

THAP4_MOUSE
NC score	0.014095 (rank : 410)	θ value	6.88961 (rank : 217)
Query Neighborhood Hits	239	Target Neighborhood Hits	130	Shared Neighborhood Hits	11
SwissProt Accessions	Q6P3Z3, Q3US28, Q6NZN6, Q6PEN6, Q91WR2, Q9CVE5, Q9CVG3	Gene names	Thap4
Domain Architecture	No domain graphic available
Description	THAP domain-containing protein 4.

K2C4_HUMAN
NC score	0.013682 (rank : 411)	θ value	3.0926 (rank : 166)
Query Neighborhood Hits	239	Target Neighborhood Hits	471	Shared Neighborhood Hits	58
SwissProt Accessions	P19013, Q6GTR8, Q96LA7, Q9BTL1	Gene names	KRT4, CYK4
Domain Architecture
Description	Keratin, type II cytoskeletal 4 (Cytokeratin-4) (CK-4) (Keratin-4) (K4).

K0241_MOUSE
NC score	0.013659 (rank : 412)	θ value	4.03905 (rank : 180)
Query Neighborhood Hits	239	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q80U56	Gene names	Kiaa0241
Domain Architecture	No domain graphic available
Description	Protein KIAA0241.

NEUM_HUMAN
NC score	0.013454 (rank : 413)	θ value	5.27518 (rank : 196)
Query Neighborhood Hits	239	Target Neighborhood Hits	132	Shared Neighborhood Hits	6
SwissProt Accessions	P17677	Gene names	GAP43
Domain Architecture
Description	Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (PP46) (Neural phosphoprotein B-50).

EPN2_MOUSE
NC score	0.013298 (rank : 414)	θ value	5.27518 (rank : 189)
Query Neighborhood Hits	239	Target Neighborhood Hits	111	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CHU3, O70447, Q8BZ85	Gene names	Epn2
Domain Architecture
Description	Epsin-2 (EPS-15-interacting protein 2) (Intersectin-EH-binding protein 2) (Ibp2).

PDE1B_MOUSE
NC score	0.013114 (rank : 415)	θ value	2.36792 (rank : 163)
Query Neighborhood Hits	239	Target Neighborhood Hits	46	Shared Neighborhood Hits	4
SwissProt Accessions	Q01065, O35384	Gene names	Pde1b, Pde1b1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

LNP_MOUSE
NC score	0.012642 (rank : 416)	θ value	5.27518 (rank : 193)
Query Neighborhood Hits	239	Target Neighborhood Hits	83	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TQ95, Q69ZC5, Q6PAQ1, Q6PEN8	Gene names	Lnp, Kiaa1715, Uln
Domain Architecture	No domain graphic available
Description	Protein lunapark (Protein ulnaless).

TRPM3_HUMAN
NC score	0.011752 (rank : 417)	θ value	5.27518 (rank : 202)
Query Neighborhood Hits	239	Target Neighborhood Hits	121	Shared Neighborhood Hits	8
SwissProt Accessions	Q9HCF6, Q5VW02, Q5VW03, Q5VW04, Q5W5T7, Q86SH0, Q86SH6, Q86UL0, Q86WK1, Q86WK2, Q86WK3, Q86WK4, Q86YZ9, Q86Z00, Q86Z01	Gene names	TRPM3, KIAA1616, LTRPC3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC3) (Melastatin-2) (MLSN2).

PELP1_MOUSE
NC score	0.011503 (rank : 418)	θ value	8.99809 (rank : 231)
Query Neighborhood Hits	239	Target Neighborhood Hits	709	Shared Neighborhood Hits	24
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

CND1_MOUSE
NC score	0.010413 (rank : 419)	θ value	5.27518 (rank : 188)
Query Neighborhood Hits	239	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K2Z4, Q8R0F2, Q8R3H0, Q922B7, Q923A3, Q9CS25, Q9CT32	Gene names	Ncapd2, Capd2, Cnap1
Domain Architecture
Description	Condensin complex subunit 1 (Non-SMC condensin I complex subunit D2) (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (mCAP-D2) (XCAP-D2 homolog).

IRX1_HUMAN
NC score	0.010301 (rank : 420)	θ value	2.36792 (rank : 162)
Query Neighborhood Hits	239	Target Neighborhood Hits	285	Shared Neighborhood Hits	4
SwissProt Accessions	P78414, Q7Z2F8, Q8N312	Gene names	IRX1, IRXA1
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-1 (Iroquois homeobox protein 1) (Homeodomain protein IRXA1).

SNX8_HUMAN
NC score	0.010181 (rank : 421)	θ value	8.99809 (rank : 236)
Query Neighborhood Hits	239	Target Neighborhood Hits	66	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y5X2, Q96I67	Gene names	SNX8
Domain Architecture
Description	Sorting nexin-8.

UBDC1_HUMAN
NC score	0.009730 (rank : 422)	θ value	6.88961 (rank : 219)
Query Neighborhood Hits	239	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BSL1, O75500, Q9UMW7	Gene names	UBADC1, GBDR1, KPC2
Domain Architecture	No domain graphic available
Description	Ubiquitin-associated domain-containing protein 1 (E3 ubiquitin-protein ligase subunit KPC2) (Kip1 ubiquitination-promoting complex protein 2) (Glialblastoma cell differentiation-related protein 1).

FBX3_MOUSE
NC score	0.009467 (rank : 423)	θ value	6.88961 (rank : 212)
Query Neighborhood Hits	239	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	Q9DC63, Q3TKB0	Gene names	Fbxo3, Fba, Fbx3
Domain Architecture
Description	F-box only protein 3.

HELZ_HUMAN
NC score	0.008205 (rank : 424)	θ value	5.27518 (rank : 190)
Query Neighborhood Hits	239	Target Neighborhood Hits	198	Shared Neighborhood Hits	7
SwissProt Accessions	P42694	Gene names	HELZ, KIAA0054
Domain Architecture	No domain graphic available
Description	Probable helicase with zinc-finger domain (EC 3.6.1.-).

NIPBL_HUMAN
NC score	0.007931 (rank : 425)	θ value	8.99809 (rank : 229)
Query Neighborhood Hits	239	Target Neighborhood Hits	1311	Shared Neighborhood Hits	44
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

IRX1_MOUSE
NC score	0.007701 (rank : 426)	θ value	5.27518 (rank : 191)
Query Neighborhood Hits	239	Target Neighborhood Hits	269	Shared Neighborhood Hits	3
SwissProt Accessions	P81068, O55120, Q9JLL6	Gene names	Irx1, Irxa1
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-1 (Iroquois homeobox protein 1) (Homeodomain protein IRXA1).

TGON2_HUMAN
NC score	0.006977 (rank : 427)	θ value	8.99809 (rank : 238)
Query Neighborhood Hits	239	Target Neighborhood Hits	1037	Shared Neighborhood Hits	24
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

RNF34_MOUSE
NC score	0.006915 (rank : 428)	θ value	8.99809 (rank : 233)
Query Neighborhood Hits	239	Target Neighborhood Hits	160	Shared Neighborhood Hits	6
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

RECK_HUMAN
NC score	0.006911 (rank : 429)	θ value	5.27518 (rank : 197)
Query Neighborhood Hits	239	Target Neighborhood Hits	189	Shared Neighborhood Hits	2
SwissProt Accessions	O95980, Q8WX37	Gene names	RECK
Domain Architecture
Description	Reversion-inducing cysteine-rich protein with Kazal motifs precursor (hRECK) (Suppressor of tumorigenicity 15) (ST15).

PK1IP_MOUSE
NC score	0.006356 (rank : 430)	θ value	1.06291 (rank : 137)
Query Neighborhood Hits	239	Target Neighborhood Hits	313	Shared Neighborhood Hits	2
SwissProt Accessions	Q9DCE5, Q3UBK7, Q80UT4, Q8C5N6, Q923K2, Q9D3E9	Gene names	Pak1ip1
Domain Architecture	No domain graphic available
Description	p21-activated protein kinase-interacting protein 1 (PAK1-interacting protein 1) (Putative PAK inhibitor Skb15).

BACH1_MOUSE
NC score	0.005719 (rank : 431)	θ value	1.81305 (rank : 148)
Query Neighborhood Hits	239	Target Neighborhood Hits	289	Shared Neighborhood Hits	14
SwissProt Accessions	P97302	Gene names	Bach1
Domain Architecture
Description	Transcription regulator protein BACH1 (BTB and CNC homolog 1).

ANK3_HUMAN
NC score	0.005615 (rank : 432)	θ value	6.88961 (rank : 204)
Query Neighborhood Hits	239	Target Neighborhood Hits	853	Shared Neighborhood Hits	27
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

SCN8A_HUMAN
NC score	0.005038 (rank : 433)	θ value	5.27518 (rank : 200)
Query Neighborhood Hits	239	Target Neighborhood Hits	135	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

ATBF1_MOUSE
NC score	0.004152 (rank : 434)	θ value	1.81305 (rank : 147)
Query Neighborhood Hits	239	Target Neighborhood Hits	1841	Shared Neighborhood Hits	31
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

DHX34_MOUSE
NC score	0.003825 (rank : 435)	θ value	4.03905 (rank : 176)
Query Neighborhood Hits	239	Target Neighborhood Hits	235	Shared Neighborhood Hits	2
SwissProt Accessions	Q9DBV3	Gene names	Dhx34, Ddx34, Kiaa0134
Domain Architecture
Description	Probable ATP-dependent RNA helicase DHX34 (EC 3.6.1.-) (DEAH box protein 34).

SCN8A_MOUSE
NC score	0.002808 (rank : 436)	θ value	8.99809 (rank : 235)
Query Neighborhood Hits	239	Target Neighborhood Hits	136	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

BAI3_MOUSE
NC score	0.002657 (rank : 437)	θ value	5.27518 (rank : 186)
Query Neighborhood Hits	239	Target Neighborhood Hits	250	Shared Neighborhood Hits	4
SwissProt Accessions	Q80ZF8	Gene names	Bai3
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

BAI3_HUMAN
NC score	0.002367 (rank : 438)	θ value	6.88961 (rank : 205)
Query Neighborhood Hits	239	Target Neighborhood Hits	246	Shared Neighborhood Hits	4
SwissProt Accessions	O60242, O60297	Gene names	BAI3, KIAA0550
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

ANDR_HUMAN
NC score	0.001933 (rank : 439)	θ value	4.03905 (rank : 171)
Query Neighborhood Hits	239	Target Neighborhood Hits	126	Shared Neighborhood Hits	3
SwissProt Accessions	P10275	Gene names	AR, DHTR, NR3C4
Domain Architecture
Description	Androgen receptor (Dihydrotestosterone receptor).

TBX4_HUMAN
NC score	0.001661 (rank : 440)	θ value	8.99809 (rank : 237)
Query Neighborhood Hits	239	Target Neighborhood Hits	70	Shared Neighborhood Hits	4
SwissProt Accessions	P57082	Gene names	TBX4
Domain Architecture
Description	T-box transcription factor TBX4 (T-box protein 4).

ATBF1_HUMAN
NC score	0.000163 (rank : 441)	θ value	4.03905 (rank : 172)
Query Neighborhood Hits	239	Target Neighborhood Hits	1547	Shared Neighborhood Hits	18
SwissProt Accessions	Q15911, O15101, Q13719	Gene names	ATBF1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

FES_MOUSE
NC score	-0.003208 (rank : 442)	θ value	1.38821 (rank : 143)
Query Neighborhood Hits	239	Target Neighborhood Hits	980	Shared Neighborhood Hits	26
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_HUMAN
NC score	-0.003271 (rank : 443)	θ value	6.88961 (rank : 213)
Query Neighborhood Hits	239	Target Neighborhood Hits	978	Shared Neighborhood Hits	20
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

NUAK2_MOUSE
NC score	-0.003468 (rank : 444)	θ value	0.47712 (rank : 122)
Query Neighborhood Hits	239	Target Neighborhood Hits	878	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

HMCN1_HUMAN
NC score	-0.004174 (rank : 445)	θ value	8.99809 (rank : 223)
Query Neighborhood Hits	239	Target Neighborhood Hits	983	Shared Neighborhood Hits	8
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).