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Network neighborhood for query Sequence : RGL2_MOUSE

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RGL2_MOUSE
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RGL2_HUMAN
θ value	0 (rank : 1)	NC score	0.995177 (rank : 2)
Query Neighborhood Hits	51	Target Neighborhood Hits	45	Shared Neighborhood Hits	29
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RGL2_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	51	Target Neighborhood Hits	51	Shared Neighborhood Hits	51
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RGL1_MOUSE
θ value	3.44927e-84 (rank : 3)	NC score	0.934307 (rank : 3)
Query Neighborhood Hits	51	Target Neighborhood Hits	42	Shared Neighborhood Hits	21
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

GNDS_HUMAN
θ value	9.0981e-77 (rank : 4)	NC score	0.894811 (rank : 6)
Query Neighborhood Hits	51	Target Neighborhood Hits	201	Shared Neighborhood Hits	22
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

GNDS_MOUSE
θ value	9.41505e-74 (rank : 5)	NC score	0.908729 (rank : 5)
Query Neighborhood Hits	51	Target Neighborhood Hits	115	Shared Neighborhood Hits	22
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RGL1_HUMAN
θ value	2.65329e-68 (rank : 6)	NC score	0.924832 (rank : 4)
Query Neighborhood Hits	51	Target Neighborhood Hits	43	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGDSR_HUMAN
θ value	2.11701e-41 (rank : 7)	NC score	0.885532 (rank : 7)
Query Neighborhood Hits	51	Target Neighborhood Hits	63	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

GNRP_HUMAN
θ value	3.88503e-19 (rank : 8)	NC score	0.574171 (rank : 10)
Query Neighborhood Hits	51	Target Neighborhood Hits	239	Shared Neighborhood Hits	21
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	1.13037e-18 (rank : 9)	NC score	0.561646 (rank : 12)
Query Neighborhood Hits	51	Target Neighborhood Hits	191	Shared Neighborhood Hits	21
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

RPGF1_HUMAN
θ value	1.38178e-16 (rank : 10)	NC score	0.682880 (rank : 8)
Query Neighborhood Hits	51	Target Neighborhood Hits	262	Shared Neighborhood Hits	22
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

SOS1_MOUSE
θ value	8.95645e-16 (rank : 11)	NC score	0.562678 (rank : 11)
Query Neighborhood Hits	51	Target Neighborhood Hits	281	Shared Neighborhood Hits	26
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS1_HUMAN
θ value	1.16975e-15 (rank : 12)	NC score	0.557336 (rank : 13)
Query Neighborhood Hits	51	Target Neighborhood Hits	274	Shared Neighborhood Hits	24
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS2_HUMAN
θ value	6.41864e-14 (rank : 13)	NC score	0.582831 (rank : 9)
Query Neighborhood Hits	51	Target Neighborhood Hits	193	Shared Neighborhood Hits	21
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

GRP3_HUMAN
θ value	8.38298e-14 (rank : 14)	NC score	0.523953 (rank : 14)
Query Neighborhood Hits	51	Target Neighborhood Hits	131	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

RPGF2_HUMAN
θ value	4.59992e-12 (rank : 15)	NC score	0.505934 (rank : 15)
Query Neighborhood Hits	51	Target Neighborhood Hits	242	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF6_HUMAN
θ value	2.52405e-10 (rank : 16)	NC score	0.484946 (rank : 16)
Query Neighborhood Hits	51	Target Neighborhood Hits	266	Shared Neighborhood Hits	23
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

RPGF3_HUMAN
θ value	7.59969e-07 (rank : 17)	NC score	0.388509 (rank : 21)
Query Neighborhood Hits	51	Target Neighborhood Hits	56	Shared Neighborhood Hits	21
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF5_HUMAN
θ value	1.69304e-06 (rank : 18)	NC score	0.474611 (rank : 17)
Query Neighborhood Hits	51	Target Neighborhood Hits	42	Shared Neighborhood Hits	21
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF5_MOUSE
θ value	3.77169e-06 (rank : 19)	NC score	0.459475 (rank : 18)
Query Neighborhood Hits	51	Target Neighborhood Hits	85	Shared Neighborhood Hits	21
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF4_HUMAN
θ value	4.92598e-06 (rank : 20)	NC score	0.425248 (rank : 19)
Query Neighborhood Hits	51	Target Neighborhood Hits	88	Shared Neighborhood Hits	21
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
θ value	6.43352e-06 (rank : 21)	NC score	0.421390 (rank : 20)
Query Neighborhood Hits	51	Target Neighborhood Hits	80	Shared Neighborhood Hits	21
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

DGKQ_HUMAN
θ value	0.0148317 (rank : 22)	NC score	0.041962 (rank : 26)
Query Neighborhood Hits	51	Target Neighborhood Hits	131	Shared Neighborhood Hits	4
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

MDC1_HUMAN
θ value	0.21417 (rank : 23)	NC score	0.036817 (rank : 27)
Query Neighborhood Hits	51	Target Neighborhood Hits	1446	Shared Neighborhood Hits	16
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

GP158_MOUSE
θ value	0.279714 (rank : 24)	NC score	0.029466 (rank : 30)
Query Neighborhood Hits	51	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C419, Q8CHB0	Gene names	Gpr158, Kiaa1136
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 158 precursor.

SOCS2_HUMAN
θ value	0.62314 (rank : 25)	NC score	0.021015 (rank : 32)
Query Neighborhood Hits	51	Target Neighborhood Hits	104	Shared Neighborhood Hits	2
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

DIDO1_HUMAN
θ value	1.38821 (rank : 26)	NC score	0.015333 (rank : 34)
Query Neighborhood Hits	51	Target Neighborhood Hits	960	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

SFR15_HUMAN
θ value	1.81305 (rank : 27)	NC score	0.035761 (rank : 28)
Query Neighborhood Hits	51	Target Neighborhood Hits	368	Shared Neighborhood Hits	10
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

CECR2_HUMAN
θ value	2.36792 (rank : 28)	NC score	0.021120 (rank : 31)
Query Neighborhood Hits	51	Target Neighborhood Hits	543	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

SSF1_MOUSE
θ value	2.36792 (rank : 29)	NC score	0.031314 (rank : 29)
Query Neighborhood Hits	51	Target Neighborhood Hits	99	Shared Neighborhood Hits	4
SwissProt Accessions	Q91YU8	Gene names	Ppan
Domain Architecture
Description	Suppressor of SWI4 1 homolog (Ssf-1) (Peter Pan homolog).

WNT6_MOUSE
θ value	2.36792 (rank : 30)	NC score	0.014904 (rank : 35)
Query Neighborhood Hits	51	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	P22727	Gene names	Wnt6, Wnt-6
Domain Architecture
Description	Protein Wnt-6 precursor.

LCB1_MOUSE
θ value	3.0926 (rank : 31)	NC score	0.014274 (rank : 36)
Query Neighborhood Hits	51	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	O35704, O54813	Gene names	Sptlc1, Lcb1
Domain Architecture
Description	Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1).

WNT6_HUMAN
θ value	3.0926 (rank : 32)	NC score	0.014046 (rank : 37)
Query Neighborhood Hits	51	Target Neighborhood Hits	52	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y6F9, Q9H1J6, Q9H238	Gene names	WNT6
Domain Architecture
Description	Protein Wnt-6 precursor.

SPEG_MOUSE
θ value	4.03905 (rank : 33)	NC score	0.000266 (rank : 52)
Query Neighborhood Hits	51	Target Neighborhood Hits	1959	Shared Neighborhood Hits	12
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

TOM1_MOUSE
θ value	4.03905 (rank : 34)	NC score	0.011231 (rank : 39)
Query Neighborhood Hits	51	Target Neighborhood Hits	53	Shared Neighborhood Hits	2
SwissProt Accessions	O88746, Q3V4C6, Q9D120	Gene names	Tom1
Domain Architecture
Description	Target of Myb protein 1.

BHLH3_MOUSE
θ value	5.27518 (rank : 35)	NC score	0.011614 (rank : 38)
Query Neighborhood Hits	51	Target Neighborhood Hits	70	Shared Neighborhood Hits	2
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

EPN3_MOUSE
θ value	5.27518 (rank : 36)	NC score	0.008188 (rank : 43)
Query Neighborhood Hits	51	Target Neighborhood Hits	312	Shared Neighborhood Hits	4
SwissProt Accessions	Q91W69, Q9CV55	Gene names	Epn3
Domain Architecture
Description	Epsin-3 (EPS-15-interacting protein 3).

MAST4_HUMAN
θ value	5.27518 (rank : 37)	NC score	0.001351 (rank : 49)
Query Neighborhood Hits	51	Target Neighborhood Hits	1804	Shared Neighborhood Hits	16
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MTR1L_HUMAN
θ value	5.27518 (rank : 38)	NC score	0.003282 (rank : 47)
Query Neighborhood Hits	51	Target Neighborhood Hits	1180	Shared Neighborhood Hits	11
SwissProt Accessions	Q13585	Gene names	GPR50
Domain Architecture
Description	Melatonin-related receptor (G protein-coupled receptor 50) (H9).

ES8L2_HUMAN
θ value	6.88961 (rank : 39)	NC score	0.006145 (rank : 45)
Query Neighborhood Hits	51	Target Neighborhood Hits	193	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

JPH4_HUMAN
θ value	6.88961 (rank : 40)	NC score	0.010622 (rank : 41)
Query Neighborhood Hits	51	Target Neighborhood Hits	103	Shared Neighborhood Hits	4
SwissProt Accessions	Q96JJ6, Q8ND44, Q96DQ0	Gene names	JPH4, JPHL1, KIAA1831
Domain Architecture	No domain graphic available
Description	Junctophilin-4 (Junctophilin-like 1 protein).

JPH4_MOUSE
θ value	6.88961 (rank : 41)	NC score	0.010710 (rank : 40)
Query Neighborhood Hits	51	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q80WT0, Q8BMI1	Gene names	Jph4, Jphl1
Domain Architecture	No domain graphic available
Description	Junctophilin-4 (Junctophilin-like 1 protein).

MEFV_HUMAN
θ value	6.88961 (rank : 42)	NC score	0.004487 (rank : 46)
Query Neighborhood Hits	51	Target Neighborhood Hits	431	Shared Neighborhood Hits	4
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

ZN668_MOUSE
θ value	6.88961 (rank : 43)	NC score	-0.002765 (rank : 55)
Query Neighborhood Hits	51	Target Neighborhood Hits	763	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K2R5, Q3TEM2, Q3U7Y5, Q8C8B7	Gene names	Znf668, Zfp668
Domain Architecture	No domain graphic available
Description	Zinc finger protein 668.

ADA2A_HUMAN
θ value	8.99809 (rank : 44)	NC score	-0.000463 (rank : 54)
Query Neighborhood Hits	51	Target Neighborhood Hits	911	Shared Neighborhood Hits	5
SwissProt Accessions	P08913, Q2XN99, Q86TH8, Q9BZK1	Gene names	ADRA2A, ADRA2R, ADRAR
Domain Architecture
Description	Alpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2A adrenoreceptor) (Alpha-2AAR) (Alpha-2 adrenergic receptor subtype C10).

ADA2A_MOUSE
θ value	8.99809 (rank : 45)	NC score	-0.000316 (rank : 53)
Query Neighborhood Hits	51	Target Neighborhood Hits	900	Shared Neighborhood Hits	6
SwissProt Accessions	Q01338	Gene names	Adra2a
Domain Architecture
Description	Alpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2A adrenoreceptor) (Alpha-2AAR).

CU024_HUMAN
θ value	8.99809 (rank : 46)	NC score	0.017725 (rank : 33)
Query Neighborhood Hits	51	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q6XXX2	Gene names	C21orf24
Domain Architecture	No domain graphic available
Description	Putative uncharacterized protein C21orf24.

FOXE2_HUMAN
θ value	8.99809 (rank : 47)	NC score	0.003095 (rank : 48)
Query Neighborhood Hits	51	Target Neighborhood Hits	236	Shared Neighborhood Hits	4
SwissProt Accessions	Q99526	Gene names	FOXE2
Domain Architecture
Description	Forkhead box protein E2 (HNF-3/fork head-like protein 5) (HFKL5) (HFKH4).

K1543_HUMAN
θ value	8.99809 (rank : 48)	NC score	0.009094 (rank : 42)
Query Neighborhood Hits	51	Target Neighborhood Hits	435	Shared Neighborhood Hits	9
SwissProt Accessions	Q9P1Y5, Q8NDF1	Gene names	KIAA1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

OTP_MOUSE
θ value	8.99809 (rank : 49)	NC score	0.000842 (rank : 51)
Query Neighborhood Hits	51	Target Neighborhood Hits	387	Shared Neighborhood Hits	2
SwissProt Accessions	O09113	Gene names	Otp
Domain Architecture
Description	Homeobox protein orthopedia.

SPEG_HUMAN
θ value	8.99809 (rank : 50)	NC score	0.000935 (rank : 50)
Query Neighborhood Hits	51	Target Neighborhood Hits	1762	Shared Neighborhood Hits	13
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

TAU_MOUSE
θ value	8.99809 (rank : 51)	NC score	0.006462 (rank : 44)
Query Neighborhood Hits	51	Target Neighborhood Hits	502	Shared Neighborhood Hits	6
SwissProt Accessions	P10637, P10638, Q60684, Q60685, Q60686, Q62286	Gene names	Mapt, Mtapt, Tau
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

CB027_HUMAN
θ value	θ > 10 (rank : 52)	NC score	0.054276 (rank : 24)
Query Neighborhood Hits	51	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q580R0, O43575, Q52M10, Q86XG2	Gene names	C2orf27
Domain Architecture	No domain graphic available
Description	Protein C2orf27.

ECT2_HUMAN
θ value	θ > 10 (rank : 53)	NC score	0.050299 (rank : 25)
Query Neighborhood Hits	51	Target Neighborhood Hits	98	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

PREX1_HUMAN
θ value	θ > 10 (rank : 54)	NC score	0.071622 (rank : 23)
Query Neighborhood Hits	51	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

RPGF3_MOUSE
θ value	θ > 10 (rank : 55)	NC score	0.320996 (rank : 22)
Query Neighborhood Hits	51	Target Neighborhood Hits	54	Shared Neighborhood Hits	18
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

Hits sorted by NC score

RGL2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	51	Target Neighborhood Hits	51	Shared Neighborhood Hits	51
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RGL2_HUMAN
NC score	0.995177 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	51	Target Neighborhood Hits	45	Shared Neighborhood Hits	29
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RGL1_MOUSE
NC score	0.934307 (rank : 3)	θ value	3.44927e-84 (rank : 3)
Query Neighborhood Hits	51	Target Neighborhood Hits	42	Shared Neighborhood Hits	21
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL1_HUMAN
NC score	0.924832 (rank : 4)	θ value	2.65329e-68 (rank : 6)
Query Neighborhood Hits	51	Target Neighborhood Hits	43	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

GNDS_MOUSE
NC score	0.908729 (rank : 5)	θ value	9.41505e-74 (rank : 5)
Query Neighborhood Hits	51	Target Neighborhood Hits	115	Shared Neighborhood Hits	22
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

GNDS_HUMAN
NC score	0.894811 (rank : 6)	θ value	9.0981e-77 (rank : 4)
Query Neighborhood Hits	51	Target Neighborhood Hits	201	Shared Neighborhood Hits	22
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RGDSR_HUMAN
NC score	0.885532 (rank : 7)	θ value	2.11701e-41 (rank : 7)
Query Neighborhood Hits	51	Target Neighborhood Hits	63	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

RPGF1_HUMAN
NC score	0.682880 (rank : 8)	θ value	1.38178e-16 (rank : 10)
Query Neighborhood Hits	51	Target Neighborhood Hits	262	Shared Neighborhood Hits	22
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

SOS2_HUMAN
NC score	0.582831 (rank : 9)	θ value	6.41864e-14 (rank : 13)
Query Neighborhood Hits	51	Target Neighborhood Hits	193	Shared Neighborhood Hits	21
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

GNRP_HUMAN
NC score	0.574171 (rank : 10)	θ value	3.88503e-19 (rank : 8)
Query Neighborhood Hits	51	Target Neighborhood Hits	239	Shared Neighborhood Hits	21
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

SOS1_MOUSE
NC score	0.562678 (rank : 11)	θ value	8.95645e-16 (rank : 11)
Query Neighborhood Hits	51	Target Neighborhood Hits	281	Shared Neighborhood Hits	26
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

GNRP_MOUSE
NC score	0.561646 (rank : 12)	θ value	1.13037e-18 (rank : 9)
Query Neighborhood Hits	51	Target Neighborhood Hits	191	Shared Neighborhood Hits	21
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

SOS1_HUMAN
NC score	0.557336 (rank : 13)	θ value	1.16975e-15 (rank : 12)
Query Neighborhood Hits	51	Target Neighborhood Hits	274	Shared Neighborhood Hits	24
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

GRP3_HUMAN
NC score	0.523953 (rank : 14)	θ value	8.38298e-14 (rank : 14)
Query Neighborhood Hits	51	Target Neighborhood Hits	131	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

RPGF2_HUMAN
NC score	0.505934 (rank : 15)	θ value	4.59992e-12 (rank : 15)
Query Neighborhood Hits	51	Target Neighborhood Hits	242	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF6_HUMAN
NC score	0.484946 (rank : 16)	θ value	2.52405e-10 (rank : 16)
Query Neighborhood Hits	51	Target Neighborhood Hits	266	Shared Neighborhood Hits	23
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

RPGF5_HUMAN
NC score	0.474611 (rank : 17)	θ value	1.69304e-06 (rank : 18)
Query Neighborhood Hits	51	Target Neighborhood Hits	42	Shared Neighborhood Hits	21
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF5_MOUSE
NC score	0.459475 (rank : 18)	θ value	3.77169e-06 (rank : 19)
Query Neighborhood Hits	51	Target Neighborhood Hits	85	Shared Neighborhood Hits	21
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF4_HUMAN
NC score	0.425248 (rank : 19)	θ value	4.92598e-06 (rank : 20)
Query Neighborhood Hits	51	Target Neighborhood Hits	88	Shared Neighborhood Hits	21
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
NC score	0.421390 (rank : 20)	θ value	6.43352e-06 (rank : 21)
Query Neighborhood Hits	51	Target Neighborhood Hits	80	Shared Neighborhood Hits	21
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF3_HUMAN
NC score	0.388509 (rank : 21)	θ value	7.59969e-07 (rank : 17)
Query Neighborhood Hits	51	Target Neighborhood Hits	56	Shared Neighborhood Hits	21
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF3_MOUSE
NC score	0.320996 (rank : 22)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	51	Target Neighborhood Hits	54	Shared Neighborhood Hits	18
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

PREX1_HUMAN
NC score	0.071622 (rank : 23)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	51	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

CB027_HUMAN
NC score	0.054276 (rank : 24)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	51	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q580R0, O43575, Q52M10, Q86XG2	Gene names	C2orf27
Domain Architecture	No domain graphic available
Description	Protein C2orf27.

ECT2_HUMAN
NC score	0.050299 (rank : 25)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	51	Target Neighborhood Hits	98	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

DGKQ_HUMAN
NC score	0.041962 (rank : 26)	θ value	0.0148317 (rank : 22)
Query Neighborhood Hits	51	Target Neighborhood Hits	131	Shared Neighborhood Hits	4
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

MDC1_HUMAN
NC score	0.036817 (rank : 27)	θ value	0.21417 (rank : 23)
Query Neighborhood Hits	51	Target Neighborhood Hits	1446	Shared Neighborhood Hits	16
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

SFR15_HUMAN
NC score	0.035761 (rank : 28)	θ value	1.81305 (rank : 27)
Query Neighborhood Hits	51	Target Neighborhood Hits	368	Shared Neighborhood Hits	10
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

SSF1_MOUSE
NC score	0.031314 (rank : 29)	θ value	2.36792 (rank : 29)
Query Neighborhood Hits	51	Target Neighborhood Hits	99	Shared Neighborhood Hits	4
SwissProt Accessions	Q91YU8	Gene names	Ppan
Domain Architecture
Description	Suppressor of SWI4 1 homolog (Ssf-1) (Peter Pan homolog).

GP158_MOUSE
NC score	0.029466 (rank : 30)	θ value	0.279714 (rank : 24)
Query Neighborhood Hits	51	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C419, Q8CHB0	Gene names	Gpr158, Kiaa1136
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 158 precursor.

CECR2_HUMAN
NC score	0.021120 (rank : 31)	θ value	2.36792 (rank : 28)
Query Neighborhood Hits	51	Target Neighborhood Hits	543	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

SOCS2_HUMAN
NC score	0.021015 (rank : 32)	θ value	0.62314 (rank : 25)
Query Neighborhood Hits	51	Target Neighborhood Hits	104	Shared Neighborhood Hits	2
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

CU024_HUMAN
NC score	0.017725 (rank : 33)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	51	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q6XXX2	Gene names	C21orf24
Domain Architecture	No domain graphic available
Description	Putative uncharacterized protein C21orf24.

DIDO1_HUMAN
NC score	0.015333 (rank : 34)	θ value	1.38821 (rank : 26)
Query Neighborhood Hits	51	Target Neighborhood Hits	960	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

WNT6_MOUSE
NC score	0.014904 (rank : 35)	θ value	2.36792 (rank : 30)
Query Neighborhood Hits	51	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	P22727	Gene names	Wnt6, Wnt-6
Domain Architecture
Description	Protein Wnt-6 precursor.

LCB1_MOUSE
NC score	0.014274 (rank : 36)	θ value	3.0926 (rank : 31)
Query Neighborhood Hits	51	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	O35704, O54813	Gene names	Sptlc1, Lcb1
Domain Architecture
Description	Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1).

WNT6_HUMAN
NC score	0.014046 (rank : 37)	θ value	3.0926 (rank : 32)
Query Neighborhood Hits	51	Target Neighborhood Hits	52	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y6F9, Q9H1J6, Q9H238	Gene names	WNT6
Domain Architecture
Description	Protein Wnt-6 precursor.

BHLH3_MOUSE
NC score	0.011614 (rank : 38)	θ value	5.27518 (rank : 35)
Query Neighborhood Hits	51	Target Neighborhood Hits	70	Shared Neighborhood Hits	2
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

TOM1_MOUSE
NC score	0.011231 (rank : 39)	θ value	4.03905 (rank : 34)
Query Neighborhood Hits	51	Target Neighborhood Hits	53	Shared Neighborhood Hits	2
SwissProt Accessions	O88746, Q3V4C6, Q9D120	Gene names	Tom1
Domain Architecture
Description	Target of Myb protein 1.

JPH4_MOUSE
NC score	0.010710 (rank : 40)	θ value	6.88961 (rank : 41)
Query Neighborhood Hits	51	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q80WT0, Q8BMI1	Gene names	Jph4, Jphl1
Domain Architecture	No domain graphic available
Description	Junctophilin-4 (Junctophilin-like 1 protein).

JPH4_HUMAN
NC score	0.010622 (rank : 41)	θ value	6.88961 (rank : 40)
Query Neighborhood Hits	51	Target Neighborhood Hits	103	Shared Neighborhood Hits	4
SwissProt Accessions	Q96JJ6, Q8ND44, Q96DQ0	Gene names	JPH4, JPHL1, KIAA1831
Domain Architecture	No domain graphic available
Description	Junctophilin-4 (Junctophilin-like 1 protein).

K1543_HUMAN
NC score	0.009094 (rank : 42)	θ value	8.99809 (rank : 48)
Query Neighborhood Hits	51	Target Neighborhood Hits	435	Shared Neighborhood Hits	9
SwissProt Accessions	Q9P1Y5, Q8NDF1	Gene names	KIAA1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

EPN3_MOUSE
NC score	0.008188 (rank : 43)	θ value	5.27518 (rank : 36)
Query Neighborhood Hits	51	Target Neighborhood Hits	312	Shared Neighborhood Hits	4
SwissProt Accessions	Q91W69, Q9CV55	Gene names	Epn3
Domain Architecture
Description	Epsin-3 (EPS-15-interacting protein 3).

TAU_MOUSE
NC score	0.006462 (rank : 44)	θ value	8.99809 (rank : 51)
Query Neighborhood Hits	51	Target Neighborhood Hits	502	Shared Neighborhood Hits	6
SwissProt Accessions	P10637, P10638, Q60684, Q60685, Q60686, Q62286	Gene names	Mapt, Mtapt, Tau
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

ES8L2_HUMAN
NC score	0.006145 (rank : 45)	θ value	6.88961 (rank : 39)
Query Neighborhood Hits	51	Target Neighborhood Hits	193	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

MEFV_HUMAN
NC score	0.004487 (rank : 46)	θ value	6.88961 (rank : 42)
Query Neighborhood Hits	51	Target Neighborhood Hits	431	Shared Neighborhood Hits	4
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

MTR1L_HUMAN
NC score	0.003282 (rank : 47)	θ value	5.27518 (rank : 38)
Query Neighborhood Hits	51	Target Neighborhood Hits	1180	Shared Neighborhood Hits	11
SwissProt Accessions	Q13585	Gene names	GPR50
Domain Architecture
Description	Melatonin-related receptor (G protein-coupled receptor 50) (H9).

FOXE2_HUMAN
NC score	0.003095 (rank : 48)	θ value	8.99809 (rank : 47)
Query Neighborhood Hits	51	Target Neighborhood Hits	236	Shared Neighborhood Hits	4
SwissProt Accessions	Q99526	Gene names	FOXE2
Domain Architecture
Description	Forkhead box protein E2 (HNF-3/fork head-like protein 5) (HFKL5) (HFKH4).

MAST4_HUMAN
NC score	0.001351 (rank : 49)	θ value	5.27518 (rank : 37)
Query Neighborhood Hits	51	Target Neighborhood Hits	1804	Shared Neighborhood Hits	16
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

SPEG_HUMAN
NC score	0.000935 (rank : 50)	θ value	8.99809 (rank : 50)
Query Neighborhood Hits	51	Target Neighborhood Hits	1762	Shared Neighborhood Hits	13
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

OTP_MOUSE
NC score	0.000842 (rank : 51)	θ value	8.99809 (rank : 49)
Query Neighborhood Hits	51	Target Neighborhood Hits	387	Shared Neighborhood Hits	2
SwissProt Accessions	O09113	Gene names	Otp
Domain Architecture
Description	Homeobox protein orthopedia.

SPEG_MOUSE
NC score	0.000266 (rank : 52)	θ value	4.03905 (rank : 33)
Query Neighborhood Hits	51	Target Neighborhood Hits	1959	Shared Neighborhood Hits	12
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

ADA2A_MOUSE
NC score	-0.000316 (rank : 53)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	51	Target Neighborhood Hits	900	Shared Neighborhood Hits	6
SwissProt Accessions	Q01338	Gene names	Adra2a
Domain Architecture
Description	Alpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2A adrenoreceptor) (Alpha-2AAR).

ADA2A_HUMAN
NC score	-0.000463 (rank : 54)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	51	Target Neighborhood Hits	911	Shared Neighborhood Hits	5
SwissProt Accessions	P08913, Q2XN99, Q86TH8, Q9BZK1	Gene names	ADRA2A, ADRA2R, ADRAR
Domain Architecture
Description	Alpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2A adrenoreceptor) (Alpha-2AAR) (Alpha-2 adrenergic receptor subtype C10).

ZN668_MOUSE
NC score	-0.002765 (rank : 55)	θ value	6.88961 (rank : 43)
Query Neighborhood Hits	51	Target Neighborhood Hits	763	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K2R5, Q3TEM2, Q3U7Y5, Q8C8B7	Gene names	Znf668, Zfp668
Domain Architecture	No domain graphic available
Description	Zinc finger protein 668.