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Network neighborhood for query Sequence : SOS2_HUMAN

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SOS2_HUMAN
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SOS1_HUMAN
θ value	0 (rank : 1)	NC score	0.961198 (rank : 2)
Query Neighborhood Hits	193	Target Neighborhood Hits	274	Shared Neighborhood Hits	119
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	0 (rank : 2)	NC score	0.960617 (rank : 3)
Query Neighborhood Hits	193	Target Neighborhood Hits	281	Shared Neighborhood Hits	115
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS2_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	193	Target Neighborhood Hits	193	Shared Neighborhood Hits	193
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

GNRP_HUMAN
θ value	9.20422e-37 (rank : 4)	NC score	0.664231 (rank : 6)
Query Neighborhood Hits	193	Target Neighborhood Hits	239	Shared Neighborhood Hits	56
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	1.46948e-34 (rank : 5)	NC score	0.679141 (rank : 5)
Query Neighborhood Hits	193	Target Neighborhood Hits	191	Shared Neighborhood Hits	57
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

RPGF1_HUMAN
θ value	2.86786e-30 (rank : 6)	NC score	0.694201 (rank : 4)
Query Neighborhood Hits	193	Target Neighborhood Hits	262	Shared Neighborhood Hits	30
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

RGL1_HUMAN
θ value	1.05554e-24 (rank : 7)	NC score	0.634584 (rank : 7)
Query Neighborhood Hits	193	Target Neighborhood Hits	43	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL1_MOUSE
θ value	2.43343e-21 (rank : 8)	NC score	0.617077 (rank : 8)
Query Neighborhood Hits	193	Target Neighborhood Hits	42	Shared Neighborhood Hits	24
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL2_HUMAN
θ value	1.13037e-18 (rank : 9)	NC score	0.598679 (rank : 9)
Query Neighborhood Hits	193	Target Neighborhood Hits	45	Shared Neighborhood Hits	21
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RPGF4_HUMAN
θ value	4.29542e-18 (rank : 10)	NC score	0.536781 (rank : 16)
Query Neighborhood Hits	193	Target Neighborhood Hits	88	Shared Neighborhood Hits	23
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
θ value	1.63225e-17 (rank : 11)	NC score	0.533390 (rank : 17)
Query Neighborhood Hits	193	Target Neighborhood Hits	80	Shared Neighborhood Hits	23
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

GNDS_HUMAN
θ value	2.13179e-17 (rank : 12)	NC score	0.571667 (rank : 12)
Query Neighborhood Hits	193	Target Neighborhood Hits	201	Shared Neighborhood Hits	41
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

GNDS_MOUSE
θ value	1.80466e-16 (rank : 13)	NC score	0.573262 (rank : 11)
Query Neighborhood Hits	193	Target Neighborhood Hits	115	Shared Neighborhood Hits	30
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RPGF5_MOUSE
θ value	1.52774e-15 (rank : 14)	NC score	0.562225 (rank : 15)
Query Neighborhood Hits	193	Target Neighborhood Hits	85	Shared Neighborhood Hits	24
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF6_HUMAN
θ value	3.40345e-15 (rank : 15)	NC score	0.498918 (rank : 19)
Query Neighborhood Hits	193	Target Neighborhood Hits	266	Shared Neighborhood Hits	34
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

ARHG9_HUMAN
θ value	7.58209e-15 (rank : 16)	NC score	0.365234 (rank : 25)
Query Neighborhood Hits	193	Target Neighborhood Hits	235	Shared Neighborhood Hits	40
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	9.90251e-15 (rank : 17)	NC score	0.365684 (rank : 24)
Query Neighborhood Hits	193	Target Neighborhood Hits	234	Shared Neighborhood Hits	40
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

RPGF2_HUMAN
θ value	1.29331e-14 (rank : 18)	NC score	0.520239 (rank : 18)
Query Neighborhood Hits	193	Target Neighborhood Hits	242	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF5_HUMAN
θ value	2.20605e-14 (rank : 19)	NC score	0.568954 (rank : 13)
Query Neighborhood Hits	193	Target Neighborhood Hits	42	Shared Neighborhood Hits	23
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RGL2_MOUSE
θ value	6.41864e-14 (rank : 20)	NC score	0.582831 (rank : 10)
Query Neighborhood Hits	193	Target Neighborhood Hits	51	Shared Neighborhood Hits	21
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

GRP3_HUMAN
θ value	5.43371e-13 (rank : 21)	NC score	0.495501 (rank : 20)
Query Neighborhood Hits	193	Target Neighborhood Hits	131	Shared Neighborhood Hits	25
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

RGDSR_HUMAN
θ value	2.69671e-12 (rank : 22)	NC score	0.568697 (rank : 14)
Query Neighborhood Hits	193	Target Neighborhood Hits	63	Shared Neighborhood Hits	25
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

RPGF3_HUMAN
θ value	6.00763e-12 (rank : 23)	NC score	0.492064 (rank : 21)
Query Neighborhood Hits	193	Target Neighborhood Hits	56	Shared Neighborhood Hits	23
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF3_MOUSE
θ value	5.08577e-11 (rank : 24)	NC score	0.470062 (rank : 22)
Query Neighborhood Hits	193	Target Neighborhood Hits	54	Shared Neighborhood Hits	22
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

PREX1_HUMAN
θ value	5.62301e-10 (rank : 25)	NC score	0.397852 (rank : 23)
Query Neighborhood Hits	193	Target Neighborhood Hits	177	Shared Neighborhood Hits	50
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

FGD3_HUMAN
θ value	1.25267e-09 (rank : 26)	NC score	0.331228 (rank : 29)
Query Neighborhood Hits	193	Target Neighborhood Hits	249	Shared Neighborhood Hits	40
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD4_MOUSE
θ value	2.79066e-09 (rank : 27)	NC score	0.325835 (rank : 31)
Query Neighborhood Hits	193	Target Neighborhood Hits	227	Shared Neighborhood Hits	48
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

PKHG1_HUMAN
θ value	3.64472e-09 (rank : 28)	NC score	0.335330 (rank : 28)
Query Neighborhood Hits	193	Target Neighborhood Hits	174	Shared Neighborhood Hits	38
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

FGD4_HUMAN
θ value	4.76016e-09 (rank : 29)	NC score	0.326115 (rank : 30)
Query Neighborhood Hits	193	Target Neighborhood Hits	219	Shared Neighborhood Hits	48
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

ARHG4_MOUSE
θ value	1.80886e-08 (rank : 30)	NC score	0.358143 (rank : 26)
Query Neighborhood Hits	193	Target Neighborhood Hits	185	Shared Neighborhood Hits	41
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_HUMAN
θ value	5.26297e-08 (rank : 31)	NC score	0.351864 (rank : 27)
Query Neighborhood Hits	193	Target Neighborhood Hits	242	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

FGD2_HUMAN
θ value	8.97725e-08 (rank : 32)	NC score	0.307398 (rank : 33)
Query Neighborhood Hits	193	Target Neighborhood Hits	151	Shared Neighborhood Hits	41
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FARP2_HUMAN
θ value	9.92553e-07 (rank : 33)	NC score	0.225380 (rank : 77)
Query Neighborhood Hits	193	Target Neighborhood Hits	240	Shared Neighborhood Hits	53
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
θ value	2.21117e-06 (rank : 34)	NC score	0.232096 (rank : 74)
Query Neighborhood Hits	193	Target Neighborhood Hits	209	Shared Neighborhood Hits	49
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FGD2_MOUSE
θ value	2.88788e-06 (rank : 35)	NC score	0.271889 (rank : 43)
Query Neighborhood Hits	193	Target Neighborhood Hits	163	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_MOUSE
θ value	3.77169e-06 (rank : 36)	NC score	0.322127 (rank : 32)
Query Neighborhood Hits	193	Target Neighborhood Hits	257	Shared Neighborhood Hits	42
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

ARHG7_HUMAN
θ value	1.09739e-05 (rank : 37)	NC score	0.271751 (rank : 44)
Query Neighborhood Hits	193	Target Neighborhood Hits	347	Shared Neighborhood Hits	50
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

FGD1_MOUSE
θ value	1.09739e-05 (rank : 38)	NC score	0.298911 (rank : 35)
Query Neighborhood Hits	193	Target Neighborhood Hits	387	Shared Neighborhood Hits	57
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_HUMAN
θ value	1.87187e-05 (rank : 39)	NC score	0.301433 (rank : 34)
Query Neighborhood Hits	193	Target Neighborhood Hits	367	Shared Neighborhood Hits	65
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ECT2_HUMAN
θ value	0.000270298 (rank : 40)	NC score	0.296909 (rank : 36)
Query Neighborhood Hits	193	Target Neighborhood Hits	98	Shared Neighborhood Hits	40
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

RGS3_MOUSE
θ value	0.000270298 (rank : 41)	NC score	0.069089 (rank : 130)
Query Neighborhood Hits	193	Target Neighborhood Hits	1621	Shared Neighborhood Hits	66
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

TRIO_HUMAN
θ value	0.00035302 (rank : 42)	NC score	0.084365 (rank : 124)
Query Neighborhood Hits	193	Target Neighborhood Hits	1580	Shared Neighborhood Hits	65
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

VAV2_MOUSE
θ value	0.000461057 (rank : 43)	NC score	0.223445 (rank : 79)
Query Neighborhood Hits	193	Target Neighborhood Hits	456	Shared Neighborhood Hits	49
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ARHG7_MOUSE
θ value	0.000602161 (rank : 44)	NC score	0.262848 (rank : 67)
Query Neighborhood Hits	193	Target Neighborhood Hits	396	Shared Neighborhood Hits	47
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

MLL3_MOUSE
θ value	0.000786445 (rank : 45)	NC score	0.080099 (rank : 127)
Query Neighborhood Hits	193	Target Neighborhood Hits	1399	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

MLL3_HUMAN
θ value	0.00102713 (rank : 46)	NC score	0.076835 (rank : 128)
Query Neighborhood Hits	193	Target Neighborhood Hits	1644	Shared Neighborhood Hits	58
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

H2AZ_HUMAN
θ value	0.00134147 (rank : 47)	NC score	0.278410 (rank : 39)
Query Neighborhood Hits	193	Target Neighborhood Hits	34	Shared Neighborhood Hits	34
SwissProt Accessions	P0C0S5, P17317, Q6I9U0	Gene names	H2AFZ, H2AZ
Domain Architecture	No domain graphic available
Description	Histone H2A.Z (H2A/z).

H2AZ_MOUSE
θ value	0.00134147 (rank : 48)	NC score	0.278410 (rank : 40)
Query Neighborhood Hits	193	Target Neighborhood Hits	34	Shared Neighborhood Hits	34
SwissProt Accessions	P0C0S6, P17317, Q3UA55, Q3UK43, Q68FD2	Gene names	H2afz, H2az
Domain Architecture	No domain graphic available
Description	Histone H2A.Z (H2A/z).

H2A1B_HUMAN
θ value	0.00175202 (rank : 49)	NC score	0.271123 (rank : 45)
Query Neighborhood Hits	193	Target Neighborhood Hits	39	Shared Neighborhood Hits	34
SwissProt Accessions	P04908	Gene names	HIST1H2AB, H2AFM
Domain Architecture
Description	Histone H2A type 1-B.

H2AV_HUMAN
θ value	0.00175202 (rank : 50)	NC score	0.277631 (rank : 41)
Query Neighborhood Hits	193	Target Neighborhood Hits	34	Shared Neighborhood Hits	34
SwissProt Accessions	Q71UI9, Q59GV8, Q6PK98	Gene names	H2AFV, H2AV
Domain Architecture	No domain graphic available
Description	Histone H2AV (H2A.F/Z).

H2AV_MOUSE
θ value	0.00175202 (rank : 51)	NC score	0.277631 (rank : 42)
Query Neighborhood Hits	193	Target Neighborhood Hits	34	Shared Neighborhood Hits	34
SwissProt Accessions	Q3THW5, Q5NC92, Q6ZWU0	Gene names	H2afv, H2av
Domain Architecture	No domain graphic available
Description	Histone H2AV (H2A.F/Z).

H2AW_HUMAN
θ value	0.00175202 (rank : 52)	NC score	0.250929 (rank : 69)
Query Neighborhood Hits	193	Target Neighborhood Hits	56	Shared Neighborhood Hits	34
SwissProt Accessions	Q9P0M6, Q5SQT2	Gene names	H2AFY2, MACROH2A2
Domain Architecture
Description	Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2).

H2AW_MOUSE
θ value	0.00175202 (rank : 53)	NC score	0.251080 (rank : 68)
Query Neighborhood Hits	193	Target Neighborhood Hits	57	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CCK0, Q3TNT4, Q925I6	Gene names	H2afy2, H2afy3
Domain Architecture	No domain graphic available
Description	Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2).

ECT2_MOUSE
θ value	0.00228821 (rank : 54)	NC score	0.289713 (rank : 37)
Query Neighborhood Hits	193	Target Neighborhood Hits	98	Shared Neighborhood Hits	40
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

H2A1C_HUMAN
θ value	0.00298849 (rank : 55)	NC score	0.268434 (rank : 51)
Query Neighborhood Hits	193	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q93077, O00775, O00776, O00777, O00778, Q540R1	Gene names	HIST1H2AC, H2AFL
Domain Architecture
Description	Histone H2A type 1-C.

H2A2B_HUMAN
θ value	0.00298849 (rank : 56)	NC score	0.269323 (rank : 48)
Query Neighborhood Hits	193	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q8IUE6	Gene names	HIST2H2AB
Domain Architecture	No domain graphic available
Description	Histone H2A type 2-B.

H2A3_HUMAN
θ value	0.00298849 (rank : 57)	NC score	0.268456 (rank : 49)
Query Neighborhood Hits	193	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	Q7L7L0	Gene names	HIST3H2A
Domain Architecture	No domain graphic available
Description	Histone H2A type 3.

H2A3_MOUSE
θ value	0.00298849 (rank : 58)	NC score	0.268456 (rank : 50)
Query Neighborhood Hits	193	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BFU2	Gene names	Hist3h2a
Domain Architecture	No domain graphic available
Description	Histone H2A type 3.

H2AX_HUMAN
θ value	0.00298849 (rank : 59)	NC score	0.270071 (rank : 47)
Query Neighborhood Hits	193	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	P16104, Q4ZGJ7, Q6IAS5	Gene names	H2AFX, H2AX
Domain Architecture
Description	Histone H2A.x (H2a/x).

H2AX_MOUSE
θ value	0.00298849 (rank : 60)	NC score	0.270285 (rank : 46)
Query Neighborhood Hits	193	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	P27661	Gene names	H2afx, H2a.x, H2ax, Hist5-2ax
Domain Architecture
Description	Histone H2A.x (H2a/x).

NGEF_HUMAN
θ value	0.00298849 (rank : 61)	NC score	0.237803 (rank : 72)
Query Neighborhood Hits	193	Target Neighborhood Hits	166	Shared Neighborhood Hits	37
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

H2A1D_HUMAN
θ value	0.00390308 (rank : 62)	NC score	0.267652 (rank : 61)
Query Neighborhood Hits	193	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	P20671, P57754, Q6FGY6	Gene names	HIST1H2AD, H2AFG
Domain Architecture
Description	Histone H2A type 1-D (H2A.3).

H2A1E_HUMAN
θ value	0.00390308 (rank : 63)	NC score	0.267645 (rank : 62)
Query Neighborhood Hits	193	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	P28001, Q76P63	Gene names	HIST1H2AE, H2AFA
Domain Architecture
Description	Histone H2A type 1-E (H2A.2) (H2A/m).

H2A1F_MOUSE
θ value	0.00390308 (rank : 64)	NC score	0.267806 (rank : 58)
Query Neighborhood Hits	193	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CGP5	Gene names	Hist1h2af
Domain Architecture	No domain graphic available
Description	Histone H2A type 1-F.

H2A1H_HUMAN
θ value	0.00390308 (rank : 65)	NC score	0.267999 (rank : 57)
Query Neighborhood Hits	193	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q96KK5	Gene names	HIST1H2AH, HIST1H2AI
Domain Architecture	No domain graphic available
Description	Histone H2A type 1-H.

H2A1H_MOUSE
θ value	0.00390308 (rank : 66)	NC score	0.268018 (rank : 56)
Query Neighborhood Hits	193	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CGP6	Gene names	Hist1h2ah
Domain Architecture	No domain graphic available
Description	Histone H2A type 1-H.

H2A1J_HUMAN
θ value	0.00390308 (rank : 67)	NC score	0.268131 (rank : 55)
Query Neighborhood Hits	193	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q99878, Q5JXQ5	Gene names	HIST1H2AJ, H2AFE
Domain Architecture
Description	Histone H2A type 1-J.

H2A1K_MOUSE
θ value	0.00390308 (rank : 68)	NC score	0.267790 (rank : 59)
Query Neighborhood Hits	193	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CGP7	Gene names	Hist1h2ak
Domain Architecture	No domain graphic available
Description	Histone H2A type 1-K.

H2A1_HUMAN
θ value	0.00390308 (rank : 69)	NC score	0.267628 (rank : 64)
Query Neighborhood Hits	193	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	P0C0S8, P02261, Q2M1R2, Q76PA6	Gene names	HIST1H2AG, H2AFP
Domain Architecture	No domain graphic available
Description	Histone H2A type 1 (H2A.1).

H2A1_MOUSE
θ value	0.00390308 (rank : 70)	NC score	0.267645 (rank : 63)
Query Neighborhood Hits	193	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	P22752, P10812, Q5SZZ2	Gene names	Hist1h2ab
Domain Architecture
Description	Histone H2A type 1.

H2A2A_HUMAN
θ value	0.00390308 (rank : 71)	NC score	0.267484 (rank : 65)
Query Neighborhood Hits	193	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q6FI13, P20670	Gene names	HIST2H2AA3, H2AFO, HIST2H2AA
Domain Architecture	No domain graphic available
Description	Histone H2A type 2-A (H2A.2).

H2A2A_MOUSE
θ value	0.00390308 (rank : 72)	NC score	0.267484 (rank : 66)
Query Neighborhood Hits	193	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q6GSS7, P20670, Q811M3	Gene names	Hist2h2aa1
Domain Architecture	No domain graphic available
Description	Histone H2A type 2-A (H2A.2) (H2a-614) (H2a-615).

H2A2B_MOUSE
θ value	0.00390308 (rank : 73)	NC score	0.268353 (rank : 52)
Query Neighborhood Hits	193	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q64522	Gene names
Domain Architecture	No domain graphic available
Description	Histone H2A type 2-B (H2a-613A).

H2A2C_HUMAN
θ value	0.00390308 (rank : 74)	NC score	0.268330 (rank : 53)
Query Neighborhood Hits	193	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q16777, Q6DRA7, Q8IUE5	Gene names	HIST2H2AC, H2AFQ
Domain Architecture
Description	Histone H2A type 2-C (H2A-GL101) (H2A/r).

H2A2C_MOUSE
θ value	0.00390308 (rank : 75)	NC score	0.268330 (rank : 54)
Query Neighborhood Hits	193	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q64523, Q8CGP3	Gene names	Hist2h2ac, Hist2h2ab
Domain Architecture	No domain graphic available
Description	Histone H2A type 2-C (H2a-613B).

VAV2_HUMAN
θ value	0.00390308 (rank : 76)	NC score	0.214071 (rank : 82)
Query Neighborhood Hits	193	Target Neighborhood Hits	453	Shared Neighborhood Hits	48
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

H2A1A_HUMAN
θ value	0.00665767 (rank : 77)	NC score	0.267693 (rank : 60)
Query Neighborhood Hits	193	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q96QV6	Gene names	HIST1H2AA
Domain Architecture	No domain graphic available
Description	Histone H2A type 1-A.

VAV3_MOUSE
θ value	0.00665767 (rank : 78)	NC score	0.223824 (rank : 78)
Query Neighborhood Hits	193	Target Neighborhood Hits	404	Shared Neighborhood Hits	48
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

PRRT3_HUMAN
θ value	0.00869519 (rank : 79)	NC score	0.049067 (rank : 143)
Query Neighborhood Hits	193	Target Neighborhood Hits	998	Shared Neighborhood Hits	43
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

H2AFB_HUMAN
θ value	0.0113563 (rank : 80)	NC score	0.281089 (rank : 38)
Query Neighborhood Hits	193	Target Neighborhood Hits	36	Shared Neighborhood Hits	34
SwissProt Accessions	P98176, Q5TZB2, Q6FG78, Q96PR7	Gene names	H2AFB3, H2ABBD, H2AFB
Domain Architecture
Description	Histone H2A-Bbd (H2A Barr body-deficient) (H2A.Bbd).

H2AY_HUMAN
θ value	0.0330416 (rank : 81)	NC score	0.241522 (rank : 71)
Query Neighborhood Hits	193	Target Neighborhood Hits	48	Shared Neighborhood Hits	34
SwissProt Accessions	O75367, O75377, Q503A8, Q7Z5E3, Q96D41, Q9H8P3, Q9UP96	Gene names	H2AFY, MACROH2A1
Domain Architecture
Description	Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205).

H2AY_MOUSE
θ value	0.0330416 (rank : 82)	NC score	0.241565 (rank : 70)
Query Neighborhood Hits	193	Target Neighborhood Hits	49	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QZQ8, Q91VZ2, Q9QZQ7	Gene names	H2afy
Domain Architecture	No domain graphic available
Description	Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (H2A.y) (H2A/y).

HAPIP_HUMAN
θ value	0.0330416 (rank : 83)	NC score	0.190910 (rank : 87)
Query Neighborhood Hits	193	Target Neighborhood Hits	350	Shared Neighborhood Hits	43
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

LCP2_HUMAN
θ value	0.0431538 (rank : 84)	NC score	0.053132 (rank : 136)
Query Neighborhood Hits	193	Target Neighborhood Hits	531	Shared Neighborhood Hits	37
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

VAV3_HUMAN
θ value	0.0431538 (rank : 85)	NC score	0.215158 (rank : 81)
Query Neighborhood Hits	193	Target Neighborhood Hits	398	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

RGS3_HUMAN
θ value	0.0563607 (rank : 86)	NC score	0.043745 (rank : 148)
Query Neighborhood Hits	193	Target Neighborhood Hits	1375	Shared Neighborhood Hits	53
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

OBSCN_HUMAN
θ value	0.0736092 (rank : 87)	NC score	0.045541 (rank : 147)
Query Neighborhood Hits	193	Target Neighborhood Hits	1931	Shared Neighborhood Hits	61
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

FGD5_MOUSE
θ value	0.163984 (rank : 88)	NC score	0.190664 (rank : 88)
Query Neighborhood Hits	193	Target Neighborhood Hits	170	Shared Neighborhood Hits	36
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

SPTB2_HUMAN
θ value	0.163984 (rank : 89)	NC score	0.037200 (rank : 156)
Query Neighborhood Hits	193	Target Neighborhood Hits	748	Shared Neighborhood Hits	26
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

ARHGC_MOUSE
θ value	0.21417 (rank : 90)	NC score	0.139168 (rank : 109)
Query Neighborhood Hits	193	Target Neighborhood Hits	344	Shared Neighborhood Hits	40
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

SPTB2_MOUSE
θ value	0.21417 (rank : 91)	NC score	0.034554 (rank : 162)
Query Neighborhood Hits	193	Target Neighborhood Hits	770	Shared Neighborhood Hits	26
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

ARHGC_HUMAN
θ value	0.279714 (rank : 92)	NC score	0.143154 (rank : 107)
Query Neighborhood Hits	193	Target Neighborhood Hits	351	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

CIC_HUMAN
θ value	0.279714 (rank : 93)	NC score	0.030355 (rank : 169)
Query Neighborhood Hits	193	Target Neighborhood Hits	992	Shared Neighborhood Hits	48
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

HCLS1_HUMAN
θ value	0.279714 (rank : 94)	NC score	0.052876 (rank : 137)
Query Neighborhood Hits	193	Target Neighborhood Hits	358	Shared Neighborhood Hits	26
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

MYO15_HUMAN
θ value	0.279714 (rank : 95)	NC score	0.021737 (rank : 188)
Query Neighborhood Hits	193	Target Neighborhood Hits	671	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

TIAM1_HUMAN
θ value	0.279714 (rank : 96)	NC score	0.230649 (rank : 75)
Query Neighborhood Hits	193	Target Neighborhood Hits	225	Shared Neighborhood Hits	52
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ANR11_HUMAN
θ value	0.365318 (rank : 97)	NC score	0.015334 (rank : 212)
Query Neighborhood Hits	193	Target Neighborhood Hits	1289	Shared Neighborhood Hits	30
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

FA47B_HUMAN
θ value	0.365318 (rank : 98)	NC score	0.037203 (rank : 155)
Query Neighborhood Hits	193	Target Neighborhood Hits	431	Shared Neighborhood Hits	29
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

PASK_HUMAN
θ value	0.365318 (rank : 99)	NC score	0.010628 (rank : 222)
Query Neighborhood Hits	193	Target Neighborhood Hits	857	Shared Neighborhood Hits	9
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

AZI1_MOUSE
θ value	0.47712 (rank : 100)	NC score	0.015142 (rank : 213)
Query Neighborhood Hits	193	Target Neighborhood Hits	990	Shared Neighborhood Hits	21
SwissProt Accessions	Q62036	Gene names	Azi1, Az1, Azi
Domain Architecture
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1).

ARHG6_HUMAN
θ value	0.62314 (rank : 101)	NC score	0.218124 (rank : 80)
Query Neighborhood Hits	193	Target Neighborhood Hits	376	Shared Neighborhood Hits	40
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ATX2_MOUSE
θ value	0.62314 (rank : 102)	NC score	0.039401 (rank : 152)
Query Neighborhood Hits	193	Target Neighborhood Hits	445	Shared Neighborhood Hits	36
SwissProt Accessions	O70305, P97421	Gene names	Atxn2, Atx2, Sca2
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein homolog).

ECM1_MOUSE
θ value	0.62314 (rank : 103)	NC score	0.028243 (rank : 171)
Query Neighborhood Hits	193	Target Neighborhood Hits	105	Shared Neighborhood Hits	6
SwissProt Accessions	Q61508	Gene names	Ecm1
Domain Architecture
Description	Extracellular matrix protein 1 precursor (Secretory component p85).

IRS1_HUMAN
θ value	0.62314 (rank : 104)	NC score	0.034154 (rank : 164)
Query Neighborhood Hits	193	Target Neighborhood Hits	109	Shared Neighborhood Hits	13
SwissProt Accessions	P35568	Gene names	IRS1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

IRS1_MOUSE
θ value	0.62314 (rank : 105)	NC score	0.033572 (rank : 166)
Query Neighborhood Hits	193	Target Neighborhood Hits	112	Shared Neighborhood Hits	10
SwissProt Accessions	P35569	Gene names	Irs1, Irs-1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

TIAM1_MOUSE
θ value	0.62314 (rank : 106)	NC score	0.228758 (rank : 76)
Query Neighborhood Hits	193	Target Neighborhood Hits	205	Shared Neighborhood Hits	52
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

GAB1_HUMAN
θ value	0.813845 (rank : 107)	NC score	0.031401 (rank : 168)
Query Neighborhood Hits	193	Target Neighborhood Hits	279	Shared Neighborhood Hits	23
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

MLL2_HUMAN
θ value	0.813845 (rank : 108)	NC score	0.049927 (rank : 142)
Query Neighborhood Hits	193	Target Neighborhood Hits	1788	Shared Neighborhood Hits	68
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

PKHG4_HUMAN
θ value	0.813845 (rank : 109)	NC score	0.180341 (rank : 93)
Query Neighborhood Hits	193	Target Neighborhood Hits	200	Shared Neighborhood Hits	36
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

SPTN4_HUMAN
θ value	0.813845 (rank : 110)	NC score	0.033651 (rank : 165)
Query Neighborhood Hits	193	Target Neighborhood Hits	570	Shared Neighborhood Hits	28
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

TNR4_HUMAN
θ value	0.813845 (rank : 111)	NC score	0.017777 (rank : 201)
Query Neighborhood Hits	193	Target Neighborhood Hits	152	Shared Neighborhood Hits	4
SwissProt Accessions	P43489, Q13663, Q5T7M0	Gene names	TNFRSF4, TXGP1L
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 4 precursor (OX40L receptor) (ACT35 antigen) (TAX transcriptionally-activated glycoprotein 1 receptor) (CD134 antigen).

ANK2_HUMAN
θ value	1.06291 (rank : 112)	NC score	0.024212 (rank : 180)
Query Neighborhood Hits	193	Target Neighborhood Hits	1615	Shared Neighborhood Hits	57
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

EP15_HUMAN
θ value	1.06291 (rank : 113)	NC score	0.018292 (rank : 198)
Query Neighborhood Hits	193	Target Neighborhood Hits	1021	Shared Neighborhood Hits	24
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

MAP1A_HUMAN
θ value	1.06291 (rank : 114)	NC score	0.023190 (rank : 185)
Query Neighborhood Hits	193	Target Neighborhood Hits	1626	Shared Neighborhood Hits	56
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

MCPH1_MOUSE
θ value	1.06291 (rank : 115)	NC score	0.024076 (rank : 182)
Query Neighborhood Hits	193	Target Neighborhood Hits	116	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TT79, Q8BNI9, Q8C9I7	Gene names	Mcph1
Domain Architecture
Description	Microcephalin.

BLNK_MOUSE
θ value	1.38821 (rank : 116)	NC score	0.073553 (rank : 129)
Query Neighborhood Hits	193	Target Neighborhood Hits	296	Shared Neighborhood Hits	29
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

CD2_HUMAN
θ value	1.38821 (rank : 117)	NC score	0.025693 (rank : 173)
Query Neighborhood Hits	193	Target Neighborhood Hits	504	Shared Neighborhood Hits	25
SwissProt Accessions	P06729, Q96TE5	Gene names	CD2
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Erythrocyte receptor) (Rosette receptor).

GSCR1_HUMAN
θ value	1.38821 (rank : 118)	NC score	0.047964 (rank : 145)
Query Neighborhood Hits	193	Target Neighborhood Hits	674	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

PASK_MOUSE
θ value	1.38821 (rank : 119)	NC score	0.007914 (rank : 227)
Query Neighborhood Hits	193	Target Neighborhood Hits	867	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

SHC1_MOUSE
θ value	1.38821 (rank : 120)	NC score	0.020610 (rank : 191)
Query Neighborhood Hits	193	Target Neighborhood Hits	180	Shared Neighborhood Hits	14
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

TPM3_HUMAN
θ value	1.38821 (rank : 121)	NC score	0.020241 (rank : 192)
Query Neighborhood Hits	193	Target Neighborhood Hits	689	Shared Neighborhood Hits	19
SwissProt Accessions	P06753, P12324, Q969Q2, Q9NQH8	Gene names	TPM3
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma) (hTM5).

TPM3_MOUSE
θ value	1.38821 (rank : 122)	NC score	0.020036 (rank : 193)
Query Neighborhood Hits	193	Target Neighborhood Hits	676	Shared Neighborhood Hits	18
SwissProt Accessions	P21107, Q09021, Q60606, Q80SW6, Q9EPW3	Gene names	Tpm3, Tpm-5, Tpm5
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma).

ACK1_MOUSE
θ value	1.81305 (rank : 123)	NC score	0.003753 (rank : 233)
Query Neighborhood Hits	193	Target Neighborhood Hits	1080	Shared Neighborhood Hits	43
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

DCC_MOUSE
θ value	1.81305 (rank : 124)	NC score	0.006915 (rank : 231)
Query Neighborhood Hits	193	Target Neighborhood Hits	896	Shared Neighborhood Hits	23
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

ETV3_HUMAN
θ value	1.81305 (rank : 125)	NC score	0.022893 (rank : 186)
Query Neighborhood Hits	193	Target Neighborhood Hits	312	Shared Neighborhood Hits	16
SwissProt Accessions	P41162, Q8TAC8, Q9BX30	Gene names	ETV3, METS, PE1
Domain Architecture	No domain graphic available
Description	ETS translocation variant 3 (ETS-domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor).

MYO15_MOUSE
θ value	1.81305 (rank : 126)	NC score	0.015617 (rank : 211)
Query Neighborhood Hits	193	Target Neighborhood Hits	467	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

NACAM_MOUSE
θ value	1.81305 (rank : 127)	NC score	0.051785 (rank : 139)
Query Neighborhood Hits	193	Target Neighborhood Hits	1866	Shared Neighborhood Hits	68
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

PHLB1_HUMAN
θ value	1.81305 (rank : 128)	NC score	0.016797 (rank : 205)
Query Neighborhood Hits	193	Target Neighborhood Hits	1038	Shared Neighborhood Hits	46
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

RIN3_HUMAN
θ value	1.81305 (rank : 129)	NC score	0.033475 (rank : 167)
Query Neighborhood Hits	193	Target Neighborhood Hits	227	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TB24, Q8NF30, Q8TEE8, Q8WYP4, Q9H6A5, Q9HAG1	Gene names	RIN3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

RIN3_MOUSE
θ value	1.81305 (rank : 130)	NC score	0.035816 (rank : 160)
Query Neighborhood Hits	193	Target Neighborhood Hits	239	Shared Neighborhood Hits	32
SwissProt Accessions	P59729	Gene names	Rin3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

TPM1_HUMAN
θ value	1.81305 (rank : 131)	NC score	0.024566 (rank : 176)
Query Neighborhood Hits	193	Target Neighborhood Hits	716	Shared Neighborhood Hits	17
SwissProt Accessions	P09493, P09494, P10469, Q86W64, Q96IK2, Q9UCY9	Gene names	TPM1, TMSA
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

TPM1_MOUSE
θ value	1.81305 (rank : 132)	NC score	0.024478 (rank : 177)
Query Neighborhood Hits	193	Target Neighborhood Hits	729	Shared Neighborhood Hits	17
SwissProt Accessions	P58771, P02558, P19354, P46902, P99034	Gene names	Tpm1, Tpm-1, Tpma
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

BAZ2A_MOUSE
θ value	2.36792 (rank : 133)	NC score	0.015959 (rank : 208)
Query Neighborhood Hits	193	Target Neighborhood Hits	744	Shared Neighborhood Hits	26
SwissProt Accessions	Q91YE5	Gene names	Baz2a, Tip5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5).

CEND1_MOUSE
θ value	2.36792 (rank : 134)	NC score	0.021641 (rank : 189)
Query Neighborhood Hits	193	Target Neighborhood Hits	260	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

DLG5_HUMAN
θ value	2.36792 (rank : 135)	NC score	0.014308 (rank : 217)
Query Neighborhood Hits	193	Target Neighborhood Hits	1088	Shared Neighborhood Hits	35
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

FHOD1_HUMAN
θ value	2.36792 (rank : 136)	NC score	0.025035 (rank : 174)
Query Neighborhood Hits	193	Target Neighborhood Hits	184	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y613, Q59F76, Q6Y1F2, Q76MS8, Q8N521	Gene names	FHOD1, FHOS
Domain Architecture
Description	FH1/FH2 domain-containing protein (Formin homolog overexpressed in spleen) (FHOS) (Formin homology 2 domain-containing protein 1).

FOG1_MOUSE
θ value	2.36792 (rank : 137)	NC score	0.002816 (rank : 234)
Query Neighborhood Hits	193	Target Neighborhood Hits	1237	Shared Neighborhood Hits	33
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

GAB1_MOUSE
θ value	2.36792 (rank : 138)	NC score	0.038554 (rank : 154)
Query Neighborhood Hits	193	Target Neighborhood Hits	233	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

MADCA_MOUSE
θ value	2.36792 (rank : 139)	NC score	0.021940 (rank : 187)
Query Neighborhood Hits	193	Target Neighborhood Hits	56	Shared Neighborhood Hits	6
SwissProt Accessions	Q61826, O35530, Q61278, Q64275, Q8R1M6	Gene names	Madcam1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (mMAdCAM-1).

TARSH_HUMAN
θ value	2.36792 (rank : 140)	NC score	0.038683 (rank : 153)
Query Neighborhood Hits	193	Target Neighborhood Hits	768	Shared Neighborhood Hits	45
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

ULK1_MOUSE
θ value	2.36792 (rank : 141)	NC score	0.001295 (rank : 236)
Query Neighborhood Hits	193	Target Neighborhood Hits	1214	Shared Neighborhood Hits	29
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

AKAP1_MOUSE
θ value	3.0926 (rank : 142)	NC score	0.016301 (rank : 207)
Query Neighborhood Hits	193	Target Neighborhood Hits	198	Shared Neighborhood Hits	14
SwissProt Accessions	O08715, O08714, P97488	Gene names	Akap1, Akap
Domain Architecture
Description	A kinase anchor protein 1, mitochondrial precursor (Protein kinase A- anchoring protein 1) (PRKA1) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Spermatid A-kinase anchor protein) (S-AKAP).

CBL_MOUSE
θ value	3.0926 (rank : 143)	NC score	0.013753 (rank : 219)
Query Neighborhood Hits	193	Target Neighborhood Hits	426	Shared Neighborhood Hits	21
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

DOK2_MOUSE
θ value	3.0926 (rank : 144)	NC score	0.012971 (rank : 220)
Query Neighborhood Hits	193	Target Neighborhood Hits	244	Shared Neighborhood Hits	12
SwissProt Accessions	O70469, O70272, Q99KL1	Gene names	Dok2, Frip
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) (Dok- related protein) (Dok-R) (IL-four receptor-interacting protein) (FRIP).

G137B_HUMAN
θ value	3.0926 (rank : 145)	NC score	0.024203 (rank : 181)
Query Neighborhood Hits	193	Target Neighborhood Hits	46	Shared Neighborhood Hits	4
SwissProt Accessions	O60478	Gene names	GPR137B, TM7SF1
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR137B (Transmembrane 7 superfamily member 1).

HXB3_HUMAN
θ value	3.0926 (rank : 146)	NC score	0.002180 (rank : 235)
Query Neighborhood Hits	193	Target Neighborhood Hits	559	Shared Neighborhood Hits	16
SwissProt Accessions	P14651, O95615, P17484	Gene names	HOXB3, HOX2G
Domain Architecture
Description	Homeobox protein Hox-B3 (Hox-2G) (Hox-2.7).

LNK_HUMAN
θ value	3.0926 (rank : 147)	NC score	0.028707 (rank : 170)
Query Neighborhood Hits	193	Target Neighborhood Hits	151	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

OSBL9_HUMAN
θ value	3.0926 (rank : 148)	NC score	0.037030 (rank : 157)
Query Neighborhood Hits	193	Target Neighborhood Hits	138	Shared Neighborhood Hits	21
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

ZCPW1_MOUSE
θ value	3.0926 (rank : 149)	NC score	0.017529 (rank : 203)
Query Neighborhood Hits	193	Target Neighborhood Hits	307	Shared Neighborhood Hits	13
SwissProt Accessions	Q6IR42	Gene names	Zcwpw1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1 homolog.

ARI1B_HUMAN
θ value	4.03905 (rank : 150)	NC score	0.026559 (rank : 172)
Query Neighborhood Hits	193	Target Neighborhood Hits	567	Shared Neighborhood Hits	33
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

CAC1G_HUMAN
θ value	4.03905 (rank : 151)	NC score	0.009712 (rank : 224)
Query Neighborhood Hits	193	Target Neighborhood Hits	587	Shared Neighborhood Hits	27
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

GLTP_MOUSE
θ value	4.03905 (rank : 152)	NC score	0.017616 (rank : 202)
Query Neighborhood Hits	193	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JL62, Q91YJ7, Q9CTK9	Gene names	Gltp
Domain Architecture	No domain graphic available
Description	Glycolipid transfer protein (GLTP).

HRX_HUMAN
θ value	4.03905 (rank : 153)	NC score	0.040188 (rank : 151)
Query Neighborhood Hits	193	Target Neighborhood Hits	825	Shared Neighborhood Hits	36
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

LNK_MOUSE
θ value	4.03905 (rank : 154)	NC score	0.024875 (rank : 175)
Query Neighborhood Hits	193	Target Neighborhood Hits	132	Shared Neighborhood Hits	12
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LR37A_HUMAN
θ value	4.03905 (rank : 155)	NC score	0.023558 (rank : 183)
Query Neighborhood Hits	193	Target Neighborhood Hits	720	Shared Neighborhood Hits	37
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

NCOA6_MOUSE
θ value	4.03905 (rank : 156)	NC score	0.036046 (rank : 159)
Query Neighborhood Hits	193	Target Neighborhood Hits	1076	Shared Neighborhood Hits	47
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

PDLI7_HUMAN
θ value	4.03905 (rank : 157)	NC score	0.018060 (rank : 200)
Query Neighborhood Hits	193	Target Neighborhood Hits	547	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

WHRN_HUMAN
θ value	4.03905 (rank : 158)	NC score	0.034259 (rank : 163)
Query Neighborhood Hits	193	Target Neighborhood Hits	325	Shared Neighborhood Hits	21
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

ARHG6_MOUSE
θ value	5.27518 (rank : 159)	NC score	0.199538 (rank : 86)
Query Neighborhood Hits	193	Target Neighborhood Hits	394	Shared Neighborhood Hits	38
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

BLNK_HUMAN
θ value	5.27518 (rank : 160)	NC score	0.041536 (rank : 150)
Query Neighborhood Hits	193	Target Neighborhood Hits	228	Shared Neighborhood Hits	24
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

CEND1_HUMAN
θ value	5.27518 (rank : 161)	NC score	0.013898 (rank : 218)
Query Neighborhood Hits	193	Target Neighborhood Hits	284	Shared Neighborhood Hits	17
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CRIS2_MOUSE
θ value	5.27518 (rank : 162)	NC score	0.021469 (rank : 190)
Query Neighborhood Hits	193	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	P16563	Gene names	Crisp2, Tpx-1, Tpx1
Domain Architecture
Description	Cysteine-rich secretory protein 2 precursor (CRISP-2) (Testis-specific protein TPX-1).

GOGB1_HUMAN
θ value	5.27518 (rank : 163)	NC score	0.008594 (rank : 225)
Query Neighborhood Hits	193	Target Neighborhood Hits	2297	Shared Neighborhood Hits	36
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

GP176_MOUSE
θ value	5.27518 (rank : 164)	NC score	-0.000807 (rank : 239)
Query Neighborhood Hits	193	Target Neighborhood Hits	539	Shared Neighborhood Hits	2
SwissProt Accessions	Q80WT4, Q80UC4	Gene names	Gpr176, Agr9, Gm1012
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 176 (G-protein coupled receptor AGR9).

JIP1_HUMAN
θ value	5.27518 (rank : 165)	NC score	0.024381 (rank : 179)
Query Neighborhood Hits	193	Target Neighborhood Hits	271	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

K1914_HUMAN
θ value	5.27518 (rank : 166)	NC score	0.036209 (rank : 158)
Query Neighborhood Hits	193	Target Neighborhood Hits	255	Shared Neighborhood Hits	19
SwissProt Accessions	Q8N4X5, Q8TB54, Q96PX4, Q96SY5	Gene names	KIAA1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

NECD_MOUSE
θ value	5.27518 (rank : 167)	NC score	0.005381 (rank : 232)
Query Neighborhood Hits	193	Target Neighborhood Hits	85	Shared Neighborhood Hits	9
SwissProt Accessions	P25233, Q542W7, Q61951	Gene names	Ndn
Domain Architecture
Description	Necdin.

SCEL_MOUSE
θ value	5.27518 (rank : 168)	NC score	0.014538 (rank : 214)
Query Neighborhood Hits	193	Target Neighborhood Hits	89	Shared Neighborhood Hits	7
SwissProt Accessions	Q9EQG3, Q9CTT9	Gene names	Scel
Domain Architecture
Description	Sciellin.

SOX13_HUMAN
θ value	5.27518 (rank : 169)	NC score	0.034691 (rank : 161)
Query Neighborhood Hits	193	Target Neighborhood Hits	464	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UN79, O95275, O95826, Q9UHW7	Gene names	SOX13
Domain Architecture
Description	SOX-13 protein (Type 1 diabetes autoantigen ICA12) (Islet cell antigen 12).

TRI66_HUMAN
θ value	5.27518 (rank : 170)	NC score	0.016911 (rank : 204)
Query Neighborhood Hits	193	Target Neighborhood Hits	479	Shared Neighborhood Hits	25
SwissProt Accessions	O15016, Q9BQQ4	Gene names	TRIM66, KIAA0298
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

UBP53_MOUSE
θ value	5.27518 (rank : 171)	NC score	0.016354 (rank : 206)
Query Neighborhood Hits	193	Target Neighborhood Hits	188	Shared Neighborhood Hits	9
SwissProt Accessions	P15975, Q8CB37, Q8R251	Gene names	Usp53, Phxr3
Domain Architecture	No domain graphic available
Description	Inactive ubiquitin carboxyl-terminal hydrolase 53 (Inactive ubiquitin- specific peptidase 53) (Per-hexamer repeat protein 3).

CB029_HUMAN
θ value	6.88961 (rank : 172)	NC score	0.015822 (rank : 209)
Query Neighborhood Hits	193	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UKZ1, Q6P2M9, Q8N681	Gene names	C2orf29
Domain Architecture	No domain graphic available
Description	Protein C2orf29.

CB029_MOUSE
θ value	6.88961 (rank : 173)	NC score	0.015702 (rank : 210)
Query Neighborhood Hits	193	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CWN7, Q3TJG9	Gene names	D1Bwg0212e
Domain Architecture	No domain graphic available
Description	Protein C2orf29 homolog.

CD248_HUMAN
θ value	6.88961 (rank : 174)	NC score	0.018335 (rank : 197)
Query Neighborhood Hits	193	Target Neighborhood Hits	679	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HCU0, Q3SX55, Q96KB6	Gene names	CD248, CD164L1, TEM1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

ETV1_HUMAN
θ value	6.88961 (rank : 175)	NC score	0.007419 (rank : 229)
Query Neighborhood Hits	193	Target Neighborhood Hits	107	Shared Neighborhood Hits	8
SwissProt Accessions	P50549, O75849, Q9UQ71, Q9Y636	Gene names	ETV1, ER81
Domain Architecture
Description	ETS translocation variant 1 (ER81 protein).

ETV1_MOUSE
θ value	6.88961 (rank : 176)	NC score	0.007115 (rank : 230)
Query Neighborhood Hits	193	Target Neighborhood Hits	92	Shared Neighborhood Hits	6
SwissProt Accessions	P41164	Gene names	Etv1, Er81, Etsrp81
Domain Architecture
Description	ETS translocation variant 1 (ER81 protein).

IRBP_HUMAN
θ value	6.88961 (rank : 177)	NC score	0.014405 (rank : 215)
Query Neighborhood Hits	193	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	P10745	Gene names	RBP3
Domain Architecture
Description	Interphotoreceptor retinoid-binding protein precursor (IRBP) (Interstitial retinol-binding protein).

IRBP_MOUSE
θ value	6.88961 (rank : 178)	NC score	0.014335 (rank : 216)
Query Neighborhood Hits	193	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	P49194, Q6B4R6, Q8VD34, Q9R0H8	Gene names	Rbp3
Domain Architecture	No domain graphic available
Description	Interphotoreceptor retinoid-binding protein precursor (IRBP) (Interstitial retinol-binding protein).

MKL1_MOUSE
θ value	6.88961 (rank : 179)	NC score	0.023331 (rank : 184)
Query Neighborhood Hits	193	Target Neighborhood Hits	667	Shared Neighborhood Hits	31
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

RAPH1_HUMAN
θ value	6.88961 (rank : 180)	NC score	0.047346 (rank : 146)
Query Neighborhood Hits	193	Target Neighborhood Hits	593	Shared Neighborhood Hits	60
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

SON_HUMAN
θ value	6.88961 (rank : 181)	NC score	0.048935 (rank : 144)
Query Neighborhood Hits	193	Target Neighborhood Hits	1568	Shared Neighborhood Hits	64
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

SOX13_MOUSE
θ value	6.88961 (rank : 182)	NC score	0.024460 (rank : 178)
Query Neighborhood Hits	193	Target Neighborhood Hits	495	Shared Neighborhood Hits	25
SwissProt Accessions	Q04891, Q922L3	Gene names	Sox13, Sox-13
Domain Architecture
Description	SOX-13 protein.

STON2_HUMAN
θ value	6.88961 (rank : 183)	NC score	0.008123 (rank : 226)
Query Neighborhood Hits	193	Target Neighborhood Hits	115	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WXE9, Q6NT47, Q96RI7, Q96RU6	Gene names	STON2, STN2, STNB
Domain Architecture
Description	Stonin-2 (Stoned B).

AHTF1_MOUSE
θ value	8.99809 (rank : 184)	NC score	0.009771 (rank : 223)
Query Neighborhood Hits	193	Target Neighborhood Hits	176	Shared Neighborhood Hits	12
SwissProt Accessions	Q8CJF7, Q8BVJ5, Q8VD55	Gene names	Ahctf1, Elys
Domain Architecture	No domain graphic available
Description	AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac).

CNKR2_HUMAN
θ value	8.99809 (rank : 185)	NC score	0.018660 (rank : 196)
Query Neighborhood Hits	193	Target Neighborhood Hits	197	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	8.99809 (rank : 186)	NC score	0.018912 (rank : 195)
Query Neighborhood Hits	193	Target Neighborhood Hits	197	Shared Neighborhood Hits	17
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

FBLN2_HUMAN
θ value	8.99809 (rank : 187)	NC score	-0.000646 (rank : 238)
Query Neighborhood Hits	193	Target Neighborhood Hits	392	Shared Neighborhood Hits	7
SwissProt Accessions	P98095	Gene names	FBLN2
Domain Architecture
Description	Fibulin-2 precursor.

JIP1_MOUSE
θ value	8.99809 (rank : 188)	NC score	0.018076 (rank : 199)
Query Neighborhood Hits	193	Target Neighborhood Hits	259	Shared Neighborhood Hits	19
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

NRP2_HUMAN
θ value	8.99809 (rank : 189)	NC score	0.000818 (rank : 237)
Query Neighborhood Hits	193	Target Neighborhood Hits	120	Shared Neighborhood Hits	2
SwissProt Accessions	O60462, O14820, O14821	Gene names	NRP2, VEGF165R2
Domain Architecture
Description	Neuropilin-2 precursor (Vascular endothelial cell growth factor 165 receptor 2).

PO6F1_MOUSE
θ value	8.99809 (rank : 190)	NC score	0.007593 (rank : 228)
Query Neighborhood Hits	193	Target Neighborhood Hits	581	Shared Neighborhood Hits	23
SwissProt Accessions	Q07916, Q91XK3	Gene names	Pou6f1, Emb
Domain Architecture
Description	POU domain, class 6, transcription factor 1 (Octamer-binding transcription factor EMB) (Transcription regulatory protein MCP-1).

RM49_MOUSE
θ value	8.99809 (rank : 191)	NC score	0.011921 (rank : 221)
Query Neighborhood Hits	193	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CQ40, Q3UC21, Q8C5R0, Q8C7P3	Gene names	Mrpl49
Domain Architecture
Description	Mitochondrial 39S ribosomal protein L49 (L49mt) (MRP-L49).

SMR2A_MOUSE
θ value	8.99809 (rank : 192)	NC score	0.019429 (rank : 194)
Query Neighborhood Hits	193	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	O09133	Gene names	Smr2, Msg2, Vcs2
Domain Architecture	No domain graphic available
Description	Submaxillary gland androgen-regulated protein 2, isoform alpha precursor (Salivary protein MSG2, isoform alpha).

ZN645_HUMAN
θ value	8.99809 (rank : 193)	NC score	0.042272 (rank : 149)
Query Neighborhood Hits	193	Target Neighborhood Hits	265	Shared Neighborhood Hits	13
SwissProt Accessions	Q8N7E2, Q6DJY9	Gene names	ZNF645
Domain Architecture	No domain graphic available
Description	Zinc finger protein 645.

ABR_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.138814 (rank : 110)
Query Neighborhood Hits	193	Target Neighborhood Hits	166	Shared Neighborhood Hits	36
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ARHG1_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.124222 (rank : 115)
Query Neighborhood Hits	193	Target Neighborhood Hits	176	Shared Neighborhood Hits	32
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 196)	NC score	0.102634 (rank : 121)
Query Neighborhood Hits	193	Target Neighborhood Hits	266	Shared Neighborhood Hits	32
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.114159 (rank : 118)
Query Neighborhood Hits	193	Target Neighborhood Hits	142	Shared Neighborhood Hits	34
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	θ > 10 (rank : 198)	NC score	0.128872 (rank : 114)
Query Neighborhood Hits	193	Target Neighborhood Hits	120	Shared Neighborhood Hits	36
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG3_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.175507 (rank : 96)
Query Neighborhood Hits	193	Target Neighborhood Hits	82	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.175610 (rank : 95)
Query Neighborhood Hits	193	Target Neighborhood Hits	85	Shared Neighborhood Hits	36
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG5_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.180394 (rank : 92)
Query Neighborhood Hits	193	Target Neighborhood Hits	172	Shared Neighborhood Hits	42
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG8_HUMAN
θ value	θ > 10 (rank : 202)	NC score	0.161086 (rank : 103)
Query Neighborhood Hits	193	Target Neighborhood Hits	85	Shared Neighborhood Hits	35
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 203)	NC score	0.144644 (rank : 106)
Query Neighborhood Hits	193	Target Neighborhood Hits	79	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGA_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.186098 (rank : 91)
Query Neighborhood Hits	193	Target Neighborhood Hits	187	Shared Neighborhood Hits	40
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 205)	NC score	0.188055 (rank : 90)
Query Neighborhood Hits	193	Target Neighborhood Hits	125	Shared Neighborhood Hits	40
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGB_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.156345 (rank : 104)
Query Neighborhood Hits	193	Target Neighborhood Hits	375	Shared Neighborhood Hits	49
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGF_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.165405 (rank : 100)
Query Neighborhood Hits	193	Target Neighborhood Hits	214	Shared Neighborhood Hits	58
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGG_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.173605 (rank : 97)
Query Neighborhood Hits	193	Target Neighborhood Hits	129	Shared Neighborhood Hits	38
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.168546 (rank : 98)
Query Neighborhood Hits	193	Target Neighborhood Hits	152	Shared Neighborhood Hits	38
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

BCL9_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.050412 (rank : 141)
Query Neighborhood Hits	193	Target Neighborhood Hits	1008	Shared Neighborhood Hits	51
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

BCR_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.132282 (rank : 111)
Query Neighborhood Hits	193	Target Neighborhood Hits	204	Shared Neighborhood Hits	40
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

CT152_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.068958 (rank : 131)
Query Neighborhood Hits	193	Target Neighborhood Hits	30	Shared Neighborhood Hits	6
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

CT152_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.055060 (rank : 134)
Query Neighborhood Hits	193	Target Neighborhood Hits	38	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

DNMBP_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.140313 (rank : 108)
Query Neighborhood Hits	193	Target Neighborhood Hits	413	Shared Neighborhood Hits	46
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
θ value	θ > 10 (rank : 215)	NC score	0.154977 (rank : 105)
Query Neighborhood Hits	193	Target Neighborhood Hits	435	Shared Neighborhood Hits	51
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DUET_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.068872 (rank : 132)
Query Neighborhood Hits	193	Target Neighborhood Hits	1220	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

FARP1_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.164170 (rank : 102)
Query Neighborhood Hits	193	Target Neighborhood Hits	241	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FGD5_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.188780 (rank : 89)
Query Neighborhood Hits	193	Target Neighborhood Hits	235	Shared Neighborhood Hits	36
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD6_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.201262 (rank : 85)
Query Neighborhood Hits	193	Target Neighborhood Hits	237	Shared Neighborhood Hits	42
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.206533 (rank : 84)
Query Neighborhood Hits	193	Target Neighborhood Hits	282	Shared Neighborhood Hits	54
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

GP155_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.051408 (rank : 140)
Query Neighborhood Hits	193	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z3F1, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6	Gene names	GPR155, PGR22
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR155 (G-protein coupled receptor PGR22).

ITSN1_HUMAN
θ value	θ > 10 (rank : 222)	NC score	0.131417 (rank : 113)
Query Neighborhood Hits	193	Target Neighborhood Hits	1757	Shared Neighborhood Hits	70
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	θ > 10 (rank : 223)	NC score	0.131566 (rank : 112)
Query Neighborhood Hits	193	Target Neighborhood Hits	1669	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.117745 (rank : 116)
Query Neighborhood Hits	193	Target Neighborhood Hits	1173	Shared Neighborhood Hits	49
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	θ > 10 (rank : 225)	NC score	0.110394 (rank : 120)
Query Neighborhood Hits	193	Target Neighborhood Hits	1371	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

LBC_HUMAN
θ value	θ > 10 (rank : 226)	NC score	0.111530 (rank : 119)
Query Neighborhood Hits	193	Target Neighborhood Hits	90	Shared Neighborhood Hits	27
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

MCF2L_MOUSE
θ value	θ > 10 (rank : 227)	NC score	0.178879 (rank : 94)
Query Neighborhood Hits	193	Target Neighborhood Hits	255	Shared Neighborhood Hits	40
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 228)	NC score	0.236309 (rank : 73)
Query Neighborhood Hits	193	Target Neighborhood Hits	166	Shared Neighborhood Hits	40
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

NCOA6_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.055237 (rank : 133)
Query Neighborhood Hits	193	Target Neighborhood Hits	1202	Shared Neighborhood Hits	46
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

NGEF_MOUSE
θ value	θ > 10 (rank : 230)	NC score	0.213226 (rank : 83)
Query Neighborhood Hits	193	Target Neighborhood Hits	228	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PKHF1_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.081892 (rank : 125)
Query Neighborhood Hits	193	Target Neighborhood Hits	76	Shared Neighborhood Hits	14
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
θ value	θ > 10 (rank : 232)	NC score	0.080902 (rank : 126)
Query Neighborhood Hits	193	Target Neighborhood Hits	80	Shared Neighborhood Hits	15
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF2_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.087734 (rank : 123)
Query Neighborhood Hits	193	Target Neighborhood Hits	75	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	θ > 10 (rank : 234)	NC score	0.087806 (rank : 122)
Query Neighborhood Hits	193	Target Neighborhood Hits	77	Shared Neighborhood Hits	15
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

RGNEF_MOUSE
θ value	θ > 10 (rank : 235)	NC score	0.117430 (rank : 117)
Query Neighborhood Hits	193	Target Neighborhood Hits	641	Shared Neighborhood Hits	43
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

VAV_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.165708 (rank : 99)
Query Neighborhood Hits	193	Target Neighborhood Hits	452	Shared Neighborhood Hits	43
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 237)	NC score	0.165352 (rank : 101)
Query Neighborhood Hits	193	Target Neighborhood Hits	430	Shared Neighborhood Hits	45
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ZFY28_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.054195 (rank : 135)
Query Neighborhood Hits	193	Target Neighborhood Hits	152	Shared Neighborhood Hits	10
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV9_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.052636 (rank : 138)
Query Neighborhood Hits	193	Target Neighborhood Hits	134	Shared Neighborhood Hits	9
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

Hits sorted by NC score

SOS2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	193	Target Neighborhood Hits	193	Shared Neighborhood Hits	193
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SOS1_HUMAN
NC score	0.961198 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	193	Target Neighborhood Hits	274	Shared Neighborhood Hits	119
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
NC score	0.960617 (rank : 3)	θ value	0 (rank : 2)
Query Neighborhood Hits	193	Target Neighborhood Hits	281	Shared Neighborhood Hits	115
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

RPGF1_HUMAN
NC score	0.694201 (rank : 4)	θ value	2.86786e-30 (rank : 6)
Query Neighborhood Hits	193	Target Neighborhood Hits	262	Shared Neighborhood Hits	30
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

GNRP_MOUSE
NC score	0.679141 (rank : 5)	θ value	1.46948e-34 (rank : 5)
Query Neighborhood Hits	193	Target Neighborhood Hits	191	Shared Neighborhood Hits	57
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GNRP_HUMAN
NC score	0.664231 (rank : 6)	θ value	9.20422e-37 (rank : 4)
Query Neighborhood Hits	193	Target Neighborhood Hits	239	Shared Neighborhood Hits	56
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

RGL1_HUMAN
NC score	0.634584 (rank : 7)	θ value	1.05554e-24 (rank : 7)
Query Neighborhood Hits	193	Target Neighborhood Hits	43	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL1_MOUSE
NC score	0.617077 (rank : 8)	θ value	2.43343e-21 (rank : 8)
Query Neighborhood Hits	193	Target Neighborhood Hits	42	Shared Neighborhood Hits	24
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL2_HUMAN
NC score	0.598679 (rank : 9)	θ value	1.13037e-18 (rank : 9)
Query Neighborhood Hits	193	Target Neighborhood Hits	45	Shared Neighborhood Hits	21
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RGL2_MOUSE
NC score	0.582831 (rank : 10)	θ value	6.41864e-14 (rank : 20)
Query Neighborhood Hits	193	Target Neighborhood Hits	51	Shared Neighborhood Hits	21
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

GNDS_MOUSE
NC score	0.573262 (rank : 11)	θ value	1.80466e-16 (rank : 13)
Query Neighborhood Hits	193	Target Neighborhood Hits	115	Shared Neighborhood Hits	30
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

GNDS_HUMAN
NC score	0.571667 (rank : 12)	θ value	2.13179e-17 (rank : 12)
Query Neighborhood Hits	193	Target Neighborhood Hits	201	Shared Neighborhood Hits	41
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RPGF5_HUMAN
NC score	0.568954 (rank : 13)	θ value	2.20605e-14 (rank : 19)
Query Neighborhood Hits	193	Target Neighborhood Hits	42	Shared Neighborhood Hits	23
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RGDSR_HUMAN
NC score	0.568697 (rank : 14)	θ value	2.69671e-12 (rank : 22)
Query Neighborhood Hits	193	Target Neighborhood Hits	63	Shared Neighborhood Hits	25
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

RPGF5_MOUSE
NC score	0.562225 (rank : 15)	θ value	1.52774e-15 (rank : 14)
Query Neighborhood Hits	193	Target Neighborhood Hits	85	Shared Neighborhood Hits	24
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF4_HUMAN
NC score	0.536781 (rank : 16)	θ value	4.29542e-18 (rank : 10)
Query Neighborhood Hits	193	Target Neighborhood Hits	88	Shared Neighborhood Hits	23
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
NC score	0.533390 (rank : 17)	θ value	1.63225e-17 (rank : 11)
Query Neighborhood Hits	193	Target Neighborhood Hits	80	Shared Neighborhood Hits	23
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF2_HUMAN
NC score	0.520239 (rank : 18)	θ value	1.29331e-14 (rank : 18)
Query Neighborhood Hits	193	Target Neighborhood Hits	242	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF6_HUMAN
NC score	0.498918 (rank : 19)	θ value	3.40345e-15 (rank : 15)
Query Neighborhood Hits	193	Target Neighborhood Hits	266	Shared Neighborhood Hits	34
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

GRP3_HUMAN
NC score	0.495501 (rank : 20)	θ value	5.43371e-13 (rank : 21)
Query Neighborhood Hits	193	Target Neighborhood Hits	131	Shared Neighborhood Hits	25
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

RPGF3_HUMAN
NC score	0.492064 (rank : 21)	θ value	6.00763e-12 (rank : 23)
Query Neighborhood Hits	193	Target Neighborhood Hits	56	Shared Neighborhood Hits	23
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF3_MOUSE
NC score	0.470062 (rank : 22)	θ value	5.08577e-11 (rank : 24)
Query Neighborhood Hits	193	Target Neighborhood Hits	54	Shared Neighborhood Hits	22
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

PREX1_HUMAN
NC score	0.397852 (rank : 23)	θ value	5.62301e-10 (rank : 25)
Query Neighborhood Hits	193	Target Neighborhood Hits	177	Shared Neighborhood Hits	50
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ARHG9_MOUSE
NC score	0.365684 (rank : 24)	θ value	9.90251e-15 (rank : 17)
Query Neighborhood Hits	193	Target Neighborhood Hits	234	Shared Neighborhood Hits	40
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG9_HUMAN
NC score	0.365234 (rank : 25)	θ value	7.58209e-15 (rank : 16)
Query Neighborhood Hits	193	Target Neighborhood Hits	235	Shared Neighborhood Hits	40
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG4_MOUSE
NC score	0.358143 (rank : 26)	θ value	1.80886e-08 (rank : 30)
Query Neighborhood Hits	193	Target Neighborhood Hits	185	Shared Neighborhood Hits	41
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_HUMAN
NC score	0.351864 (rank : 27)	θ value	5.26297e-08 (rank : 31)
Query Neighborhood Hits	193	Target Neighborhood Hits	242	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PKHG1_HUMAN
NC score	0.335330 (rank : 28)	θ value	3.64472e-09 (rank : 28)
Query Neighborhood Hits	193	Target Neighborhood Hits	174	Shared Neighborhood Hits	38
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

FGD3_HUMAN
NC score	0.331228 (rank : 29)	θ value	1.25267e-09 (rank : 26)
Query Neighborhood Hits	193	Target Neighborhood Hits	249	Shared Neighborhood Hits	40
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD4_HUMAN
NC score	0.326115 (rank : 30)	θ value	4.76016e-09 (rank : 29)
Query Neighborhood Hits	193	Target Neighborhood Hits	219	Shared Neighborhood Hits	48
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
NC score	0.325835 (rank : 31)	θ value	2.79066e-09 (rank : 27)
Query Neighborhood Hits	193	Target Neighborhood Hits	227	Shared Neighborhood Hits	48
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD3_MOUSE
NC score	0.322127 (rank : 32)	θ value	3.77169e-06 (rank : 36)
Query Neighborhood Hits	193	Target Neighborhood Hits	257	Shared Neighborhood Hits	42
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD2_HUMAN
NC score	0.307398 (rank : 33)	θ value	8.97725e-08 (rank : 32)
Query Neighborhood Hits	193	Target Neighborhood Hits	151	Shared Neighborhood Hits	41
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD1_HUMAN
NC score	0.301433 (rank : 34)	θ value	1.87187e-05 (rank : 39)
Query Neighborhood Hits	193	Target Neighborhood Hits	367	Shared Neighborhood Hits	65
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
NC score	0.298911 (rank : 35)	θ value	1.09739e-05 (rank : 38)
Query Neighborhood Hits	193	Target Neighborhood Hits	387	Shared Neighborhood Hits	57
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ECT2_HUMAN
NC score	0.296909 (rank : 36)	θ value	0.000270298 (rank : 40)
Query Neighborhood Hits	193	Target Neighborhood Hits	98	Shared Neighborhood Hits	40
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
NC score	0.289713 (rank : 37)	θ value	0.00228821 (rank : 54)
Query Neighborhood Hits	193	Target Neighborhood Hits	98	Shared Neighborhood Hits	40
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

H2AFB_HUMAN
NC score	0.281089 (rank : 38)	θ value	0.0113563 (rank : 80)
Query Neighborhood Hits	193	Target Neighborhood Hits	36	Shared Neighborhood Hits	34
SwissProt Accessions	P98176, Q5TZB2, Q6FG78, Q96PR7	Gene names	H2AFB3, H2ABBD, H2AFB
Domain Architecture
Description	Histone H2A-Bbd (H2A Barr body-deficient) (H2A.Bbd).

H2AZ_HUMAN
NC score	0.278410 (rank : 39)	θ value	0.00134147 (rank : 47)
Query Neighborhood Hits	193	Target Neighborhood Hits	34	Shared Neighborhood Hits	34
SwissProt Accessions	P0C0S5, P17317, Q6I9U0	Gene names	H2AFZ, H2AZ
Domain Architecture	No domain graphic available
Description	Histone H2A.Z (H2A/z).

H2AZ_MOUSE
NC score	0.278410 (rank : 40)	θ value	0.00134147 (rank : 48)
Query Neighborhood Hits	193	Target Neighborhood Hits	34	Shared Neighborhood Hits	34
SwissProt Accessions	P0C0S6, P17317, Q3UA55, Q3UK43, Q68FD2	Gene names	H2afz, H2az
Domain Architecture	No domain graphic available
Description	Histone H2A.Z (H2A/z).

H2AV_HUMAN
NC score	0.277631 (rank : 41)	θ value	0.00175202 (rank : 50)
Query Neighborhood Hits	193	Target Neighborhood Hits	34	Shared Neighborhood Hits	34
SwissProt Accessions	Q71UI9, Q59GV8, Q6PK98	Gene names	H2AFV, H2AV
Domain Architecture	No domain graphic available
Description	Histone H2AV (H2A.F/Z).

H2AV_MOUSE
NC score	0.277631 (rank : 42)	θ value	0.00175202 (rank : 51)
Query Neighborhood Hits	193	Target Neighborhood Hits	34	Shared Neighborhood Hits	34
SwissProt Accessions	Q3THW5, Q5NC92, Q6ZWU0	Gene names	H2afv, H2av
Domain Architecture	No domain graphic available
Description	Histone H2AV (H2A.F/Z).

FGD2_MOUSE
NC score	0.271889 (rank : 43)	θ value	2.88788e-06 (rank : 35)
Query Neighborhood Hits	193	Target Neighborhood Hits	163	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

ARHG7_HUMAN
NC score	0.271751 (rank : 44)	θ value	1.09739e-05 (rank : 37)
Query Neighborhood Hits	193	Target Neighborhood Hits	347	Shared Neighborhood Hits	50
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

H2A1B_HUMAN
NC score	0.271123 (rank : 45)	θ value	0.00175202 (rank : 49)
Query Neighborhood Hits	193	Target Neighborhood Hits	39	Shared Neighborhood Hits	34
SwissProt Accessions	P04908	Gene names	HIST1H2AB, H2AFM
Domain Architecture
Description	Histone H2A type 1-B.

H2AX_MOUSE
NC score	0.270285 (rank : 46)	θ value	0.00298849 (rank : 60)
Query Neighborhood Hits	193	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	P27661	Gene names	H2afx, H2a.x, H2ax, Hist5-2ax
Domain Architecture
Description	Histone H2A.x (H2a/x).

H2AX_HUMAN
NC score	0.270071 (rank : 47)	θ value	0.00298849 (rank : 59)
Query Neighborhood Hits	193	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	P16104, Q4ZGJ7, Q6IAS5	Gene names	H2AFX, H2AX
Domain Architecture
Description	Histone H2A.x (H2a/x).

H2A2B_HUMAN
NC score	0.269323 (rank : 48)	θ value	0.00298849 (rank : 56)
Query Neighborhood Hits	193	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q8IUE6	Gene names	HIST2H2AB
Domain Architecture	No domain graphic available
Description	Histone H2A type 2-B.

H2A3_HUMAN
NC score	0.268456 (rank : 49)	θ value	0.00298849 (rank : 57)
Query Neighborhood Hits	193	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	Q7L7L0	Gene names	HIST3H2A
Domain Architecture	No domain graphic available
Description	Histone H2A type 3.

H2A3_MOUSE
NC score	0.268456 (rank : 50)	θ value	0.00298849 (rank : 58)
Query Neighborhood Hits	193	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BFU2	Gene names	Hist3h2a
Domain Architecture	No domain graphic available
Description	Histone H2A type 3.

H2A1C_HUMAN
NC score	0.268434 (rank : 51)	θ value	0.00298849 (rank : 55)
Query Neighborhood Hits	193	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q93077, O00775, O00776, O00777, O00778, Q540R1	Gene names	HIST1H2AC, H2AFL
Domain Architecture
Description	Histone H2A type 1-C.

H2A2B_MOUSE
NC score	0.268353 (rank : 52)	θ value	0.00390308 (rank : 73)
Query Neighborhood Hits	193	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q64522	Gene names
Domain Architecture	No domain graphic available
Description	Histone H2A type 2-B (H2a-613A).

H2A2C_HUMAN
NC score	0.268330 (rank : 53)	θ value	0.00390308 (rank : 74)
Query Neighborhood Hits	193	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q16777, Q6DRA7, Q8IUE5	Gene names	HIST2H2AC, H2AFQ
Domain Architecture
Description	Histone H2A type 2-C (H2A-GL101) (H2A/r).

H2A2C_MOUSE
NC score	0.268330 (rank : 54)	θ value	0.00390308 (rank : 75)
Query Neighborhood Hits	193	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q64523, Q8CGP3	Gene names	Hist2h2ac, Hist2h2ab
Domain Architecture	No domain graphic available
Description	Histone H2A type 2-C (H2a-613B).

H2A1J_HUMAN
NC score	0.268131 (rank : 55)	θ value	0.00390308 (rank : 67)
Query Neighborhood Hits	193	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q99878, Q5JXQ5	Gene names	HIST1H2AJ, H2AFE
Domain Architecture
Description	Histone H2A type 1-J.

H2A1H_MOUSE
NC score	0.268018 (rank : 56)	θ value	0.00390308 (rank : 66)
Query Neighborhood Hits	193	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CGP6	Gene names	Hist1h2ah
Domain Architecture	No domain graphic available
Description	Histone H2A type 1-H.

H2A1H_HUMAN
NC score	0.267999 (rank : 57)	θ value	0.00390308 (rank : 65)
Query Neighborhood Hits	193	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q96KK5	Gene names	HIST1H2AH, HIST1H2AI
Domain Architecture	No domain graphic available
Description	Histone H2A type 1-H.

H2A1F_MOUSE
NC score	0.267806 (rank : 58)	θ value	0.00390308 (rank : 64)
Query Neighborhood Hits	193	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CGP5	Gene names	Hist1h2af
Domain Architecture	No domain graphic available
Description	Histone H2A type 1-F.

H2A1K_MOUSE
NC score	0.267790 (rank : 59)	θ value	0.00390308 (rank : 68)
Query Neighborhood Hits	193	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CGP7	Gene names	Hist1h2ak
Domain Architecture	No domain graphic available
Description	Histone H2A type 1-K.

H2A1A_HUMAN
NC score	0.267693 (rank : 60)	θ value	0.00665767 (rank : 77)
Query Neighborhood Hits	193	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q96QV6	Gene names	HIST1H2AA
Domain Architecture	No domain graphic available
Description	Histone H2A type 1-A.

H2A1D_HUMAN
NC score	0.267652 (rank : 61)	θ value	0.00390308 (rank : 62)
Query Neighborhood Hits	193	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	P20671, P57754, Q6FGY6	Gene names	HIST1H2AD, H2AFG
Domain Architecture
Description	Histone H2A type 1-D (H2A.3).

H2A1E_HUMAN
NC score	0.267645 (rank : 62)	θ value	0.00390308 (rank : 63)
Query Neighborhood Hits	193	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	P28001, Q76P63	Gene names	HIST1H2AE, H2AFA
Domain Architecture
Description	Histone H2A type 1-E (H2A.2) (H2A/m).

H2A1_MOUSE
NC score	0.267645 (rank : 63)	θ value	0.00390308 (rank : 70)
Query Neighborhood Hits	193	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	P22752, P10812, Q5SZZ2	Gene names	Hist1h2ab
Domain Architecture
Description	Histone H2A type 1.

H2A1_HUMAN
NC score	0.267628 (rank : 64)	θ value	0.00390308 (rank : 69)
Query Neighborhood Hits	193	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	P0C0S8, P02261, Q2M1R2, Q76PA6	Gene names	HIST1H2AG, H2AFP
Domain Architecture	No domain graphic available
Description	Histone H2A type 1 (H2A.1).

H2A2A_HUMAN
NC score	0.267484 (rank : 65)	θ value	0.00390308 (rank : 71)
Query Neighborhood Hits	193	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q6FI13, P20670	Gene names	HIST2H2AA3, H2AFO, HIST2H2AA
Domain Architecture	No domain graphic available
Description	Histone H2A type 2-A (H2A.2).

H2A2A_MOUSE
NC score	0.267484 (rank : 66)	θ value	0.00390308 (rank : 72)
Query Neighborhood Hits	193	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q6GSS7, P20670, Q811M3	Gene names	Hist2h2aa1
Domain Architecture	No domain graphic available
Description	Histone H2A type 2-A (H2A.2) (H2a-614) (H2a-615).

ARHG7_MOUSE
NC score	0.262848 (rank : 67)	θ value	0.000602161 (rank : 44)
Query Neighborhood Hits	193	Target Neighborhood Hits	396	Shared Neighborhood Hits	47
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

H2AW_MOUSE
NC score	0.251080 (rank : 68)	θ value	0.00175202 (rank : 53)
Query Neighborhood Hits	193	Target Neighborhood Hits	57	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CCK0, Q3TNT4, Q925I6	Gene names	H2afy2, H2afy3
Domain Architecture	No domain graphic available
Description	Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2).

H2AW_HUMAN
NC score	0.250929 (rank : 69)	θ value	0.00175202 (rank : 52)
Query Neighborhood Hits	193	Target Neighborhood Hits	56	Shared Neighborhood Hits	34
SwissProt Accessions	Q9P0M6, Q5SQT2	Gene names	H2AFY2, MACROH2A2
Domain Architecture
Description	Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2).

H2AY_MOUSE
NC score	0.241565 (rank : 70)	θ value	0.0330416 (rank : 82)
Query Neighborhood Hits	193	Target Neighborhood Hits	49	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QZQ8, Q91VZ2, Q9QZQ7	Gene names	H2afy
Domain Architecture	No domain graphic available
Description	Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (H2A.y) (H2A/y).

H2AY_HUMAN
NC score	0.241522 (rank : 71)	θ value	0.0330416 (rank : 81)
Query Neighborhood Hits	193	Target Neighborhood Hits	48	Shared Neighborhood Hits	34
SwissProt Accessions	O75367, O75377, Q503A8, Q7Z5E3, Q96D41, Q9H8P3, Q9UP96	Gene names	H2AFY, MACROH2A1
Domain Architecture
Description	Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205).

NGEF_HUMAN
NC score	0.237803 (rank : 72)	θ value	0.00298849 (rank : 61)
Query Neighborhood Hits	193	Target Neighborhood Hits	166	Shared Neighborhood Hits	37
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

MCF2_HUMAN
NC score	0.236309 (rank : 73)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	193	Target Neighborhood Hits	166	Shared Neighborhood Hits	40
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

FARP2_MOUSE
NC score	0.232096 (rank : 74)	θ value	2.21117e-06 (rank : 34)
Query Neighborhood Hits	193	Target Neighborhood Hits	209	Shared Neighborhood Hits	49
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

TIAM1_HUMAN
NC score	0.230649 (rank : 75)	θ value	0.279714 (rank : 96)
Query Neighborhood Hits	193	Target Neighborhood Hits	225	Shared Neighborhood Hits	52
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
NC score	0.228758 (rank : 76)	θ value	0.62314 (rank : 106)
Query Neighborhood Hits	193	Target Neighborhood Hits	205	Shared Neighborhood Hits	52
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

FARP2_HUMAN
NC score	0.225380 (rank : 77)	θ value	9.92553e-07 (rank : 33)
Query Neighborhood Hits	193	Target Neighborhood Hits	240	Shared Neighborhood Hits	53
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

VAV3_MOUSE
NC score	0.223824 (rank : 78)	θ value	0.00665767 (rank : 78)
Query Neighborhood Hits	193	Target Neighborhood Hits	404	Shared Neighborhood Hits	48
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV2_MOUSE
NC score	0.223445 (rank : 79)	θ value	0.000461057 (rank : 43)
Query Neighborhood Hits	193	Target Neighborhood Hits	456	Shared Neighborhood Hits	49
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ARHG6_HUMAN
NC score	0.218124 (rank : 80)	θ value	0.62314 (rank : 101)
Query Neighborhood Hits	193	Target Neighborhood Hits	376	Shared Neighborhood Hits	40
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

VAV3_HUMAN
NC score	0.215158 (rank : 81)	θ value	0.0431538 (rank : 85)
Query Neighborhood Hits	193	Target Neighborhood Hits	398	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV2_HUMAN
NC score	0.214071 (rank : 82)	θ value	0.00390308 (rank : 76)
Query Neighborhood Hits	193	Target Neighborhood Hits	453	Shared Neighborhood Hits	48
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

NGEF_MOUSE
NC score	0.213226 (rank : 83)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	193	Target Neighborhood Hits	228	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

FGD6_MOUSE
NC score	0.206533 (rank : 84)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	193	Target Neighborhood Hits	282	Shared Neighborhood Hits	54
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD6_HUMAN
NC score	0.201262 (rank : 85)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	193	Target Neighborhood Hits	237	Shared Neighborhood Hits	42
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

ARHG6_MOUSE
NC score	0.199538 (rank : 86)	θ value	5.27518 (rank : 159)
Query Neighborhood Hits	193	Target Neighborhood Hits	394	Shared Neighborhood Hits	38
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

HAPIP_HUMAN
NC score	0.190910 (rank : 87)	θ value	0.0330416 (rank : 83)
Query Neighborhood Hits	193	Target Neighborhood Hits	350	Shared Neighborhood Hits	43
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

FGD5_MOUSE
NC score	0.190664 (rank : 88)	θ value	0.163984 (rank : 88)
Query Neighborhood Hits	193	Target Neighborhood Hits	170	Shared Neighborhood Hits	36
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FGD5_HUMAN
NC score	0.188780 (rank : 89)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	193	Target Neighborhood Hits	235	Shared Neighborhood Hits	36
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

ARHGA_MOUSE
NC score	0.188055 (rank : 90)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	193	Target Neighborhood Hits	125	Shared Neighborhood Hits	40
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_HUMAN
NC score	0.186098 (rank : 91)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	193	Target Neighborhood Hits	187	Shared Neighborhood Hits	40
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHG5_HUMAN
NC score	0.180394 (rank : 92)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	193	Target Neighborhood Hits	172	Shared Neighborhood Hits	42
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

PKHG4_HUMAN
NC score	0.180341 (rank : 93)	θ value	0.813845 (rank : 109)
Query Neighborhood Hits	193	Target Neighborhood Hits	200	Shared Neighborhood Hits	36
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

MCF2L_MOUSE
NC score	0.178879 (rank : 94)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	193	Target Neighborhood Hits	255	Shared Neighborhood Hits	40
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

ARHG3_MOUSE
NC score	0.175610 (rank : 95)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	193	Target Neighborhood Hits	85	Shared Neighborhood Hits	36
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG3_HUMAN
NC score	0.175507 (rank : 96)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	193	Target Neighborhood Hits	82	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHGG_HUMAN
NC score	0.173605 (rank : 97)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	193	Target Neighborhood Hits	129	Shared Neighborhood Hits	38
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
NC score	0.168546 (rank : 98)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	193	Target Neighborhood Hits	152	Shared Neighborhood Hits	38
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

VAV_HUMAN
NC score	0.165708 (rank : 99)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	193	Target Neighborhood Hits	452	Shared Neighborhood Hits	43
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ARHGF_HUMAN
NC score	0.165405 (rank : 100)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	193	Target Neighborhood Hits	214	Shared Neighborhood Hits	58
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

VAV_MOUSE
NC score	0.165352 (rank : 101)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	193	Target Neighborhood Hits	430	Shared Neighborhood Hits	45
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

FARP1_HUMAN
NC score	0.164170 (rank : 102)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	193	Target Neighborhood Hits	241	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

ARHG8_HUMAN
NC score	0.161086 (rank : 103)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	193	Target Neighborhood Hits	85	Shared Neighborhood Hits	35
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHGB_HUMAN
NC score	0.156345 (rank : 104)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	193	Target Neighborhood Hits	375	Shared Neighborhood Hits	49
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

DNMBP_MOUSE
NC score	0.154977 (rank : 105)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	193	Target Neighborhood Hits	435	Shared Neighborhood Hits	51
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHG8_MOUSE
NC score	0.144644 (rank : 106)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	193	Target Neighborhood Hits	79	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGC_HUMAN
NC score	0.143154 (rank : 107)	θ value	0.279714 (rank : 92)
Query Neighborhood Hits	193	Target Neighborhood Hits	351	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

DNMBP_HUMAN
NC score	0.140313 (rank : 108)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	193	Target Neighborhood Hits	413	Shared Neighborhood Hits	46
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHGC_MOUSE
NC score	0.139168 (rank : 109)	θ value	0.21417 (rank : 90)
Query Neighborhood Hits	193	Target Neighborhood Hits	344	Shared Neighborhood Hits	40
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ABR_HUMAN
NC score	0.138814 (rank : 110)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	193	Target Neighborhood Hits	166	Shared Neighborhood Hits	36
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

BCR_HUMAN
NC score	0.132282 (rank : 111)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	193	Target Neighborhood Hits	204	Shared Neighborhood Hits	40
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ITSN1_MOUSE
NC score	0.131566 (rank : 112)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	193	Target Neighborhood Hits	1669	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN1_HUMAN
NC score	0.131417 (rank : 113)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	193	Target Neighborhood Hits	1757	Shared Neighborhood Hits	70
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ARHG2_MOUSE
NC score	0.128872 (rank : 114)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	193	Target Neighborhood Hits	120	Shared Neighborhood Hits	36
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG1_HUMAN
NC score	0.124222 (rank : 115)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	193	Target Neighborhood Hits	176	Shared Neighborhood Hits	32
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ITSN2_HUMAN
NC score	0.117745 (rank : 116)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	193	Target Neighborhood Hits	1173	Shared Neighborhood Hits	49
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

RGNEF_MOUSE
NC score	0.117430 (rank : 117)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	193	Target Neighborhood Hits	641	Shared Neighborhood Hits	43
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ARHG2_HUMAN
NC score	0.114159 (rank : 118)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	193	Target Neighborhood Hits	142	Shared Neighborhood Hits	34
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

LBC_HUMAN
NC score	0.111530 (rank : 119)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	193	Target Neighborhood Hits	90	Shared Neighborhood Hits	27
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ITSN2_MOUSE
NC score	0.110394 (rank : 120)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	193	Target Neighborhood Hits	1371	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ARHG1_MOUSE
NC score	0.102634 (rank : 121)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	193	Target Neighborhood Hits	266	Shared Neighborhood Hits	32
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

PKHF2_MOUSE
NC score	0.087806 (rank : 122)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	193	Target Neighborhood Hits	77	Shared Neighborhood Hits	15
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHF2_HUMAN
NC score	0.087734 (rank : 123)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	193	Target Neighborhood Hits	75	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

TRIO_HUMAN
NC score	0.084365 (rank : 124)	θ value	0.00035302 (rank : 42)
Query Neighborhood Hits	193	Target Neighborhood Hits	1580	Shared Neighborhood Hits	65
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

PKHF1_HUMAN
NC score	0.081892 (rank : 125)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	193	Target Neighborhood Hits	76	Shared Neighborhood Hits	14
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
NC score	0.080902 (rank : 126)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	193	Target Neighborhood Hits	80	Shared Neighborhood Hits	15
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

MLL3_MOUSE
NC score	0.080099 (rank : 127)	θ value	0.000786445 (rank : 45)
Query Neighborhood Hits	193	Target Neighborhood Hits	1399	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

MLL3_HUMAN
NC score	0.076835 (rank : 128)	θ value	0.00102713 (rank : 46)
Query Neighborhood Hits	193	Target Neighborhood Hits	1644	Shared Neighborhood Hits	58
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

BLNK_MOUSE
NC score	0.073553 (rank : 129)	θ value	1.38821 (rank : 116)
Query Neighborhood Hits	193	Target Neighborhood Hits	296	Shared Neighborhood Hits	29
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

RGS3_MOUSE
NC score	0.069089 (rank : 130)	θ value	0.000270298 (rank : 41)
Query Neighborhood Hits	193	Target Neighborhood Hits	1621	Shared Neighborhood Hits	66
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

CT152_HUMAN
NC score	0.068958 (rank : 131)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	193	Target Neighborhood Hits	30	Shared Neighborhood Hits	6
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

DUET_HUMAN
NC score	0.068872 (rank : 132)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	193	Target Neighborhood Hits	1220	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

NCOA6_HUMAN
NC score	0.055237 (rank : 133)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	193	Target Neighborhood Hits	1202	Shared Neighborhood Hits	46
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

CT152_MOUSE
NC score	0.055060 (rank : 134)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	193	Target Neighborhood Hits	38	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

ZFY28_HUMAN
NC score	0.054195 (rank : 135)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	193	Target Neighborhood Hits	152	Shared Neighborhood Hits	10
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

LCP2_HUMAN
NC score	0.053132 (rank : 136)	θ value	0.0431538 (rank : 84)
Query Neighborhood Hits	193	Target Neighborhood Hits	531	Shared Neighborhood Hits	37
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

HCLS1_HUMAN
NC score	0.052876 (rank : 137)	θ value	0.279714 (rank : 94)
Query Neighborhood Hits	193	Target Neighborhood Hits	358	Shared Neighborhood Hits	26
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

ZFYV9_HUMAN
NC score	0.052636 (rank : 138)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	193	Target Neighborhood Hits	134	Shared Neighborhood Hits	9
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

NACAM_MOUSE
NC score	0.051785 (rank : 139)	θ value	1.81305 (rank : 127)
Query Neighborhood Hits	193	Target Neighborhood Hits	1866	Shared Neighborhood Hits	68
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

GP155_HUMAN
NC score	0.051408 (rank : 140)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	193	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z3F1, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6	Gene names	GPR155, PGR22
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR155 (G-protein coupled receptor PGR22).

BCL9_HUMAN
NC score	0.050412 (rank : 141)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	193	Target Neighborhood Hits	1008	Shared Neighborhood Hits	51
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

MLL2_HUMAN
NC score	0.049927 (rank : 142)	θ value	0.813845 (rank : 108)
Query Neighborhood Hits	193	Target Neighborhood Hits	1788	Shared Neighborhood Hits	68
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

PRRT3_HUMAN
NC score	0.049067 (rank : 143)	θ value	0.00869519 (rank : 79)
Query Neighborhood Hits	193	Target Neighborhood Hits	998	Shared Neighborhood Hits	43
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

SON_HUMAN
NC score	0.048935 (rank : 144)	θ value	6.88961 (rank : 181)
Query Neighborhood Hits	193	Target Neighborhood Hits	1568	Shared Neighborhood Hits	64
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

GSCR1_HUMAN
NC score	0.047964 (rank : 145)	θ value	1.38821 (rank : 118)
Query Neighborhood Hits	193	Target Neighborhood Hits	674	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

RAPH1_HUMAN
NC score	0.047346 (rank : 146)	θ value	6.88961 (rank : 180)
Query Neighborhood Hits	193	Target Neighborhood Hits	593	Shared Neighborhood Hits	60
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

OBSCN_HUMAN
NC score	0.045541 (rank : 147)	θ value	0.0736092 (rank : 87)
Query Neighborhood Hits	193	Target Neighborhood Hits	1931	Shared Neighborhood Hits	61
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

RGS3_HUMAN
NC score	0.043745 (rank : 148)	θ value	0.0563607 (rank : 86)
Query Neighborhood Hits	193	Target Neighborhood Hits	1375	Shared Neighborhood Hits	53
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

ZN645_HUMAN
NC score	0.042272 (rank : 149)	θ value	8.99809 (rank : 193)
Query Neighborhood Hits	193	Target Neighborhood Hits	265	Shared Neighborhood Hits	13
SwissProt Accessions	Q8N7E2, Q6DJY9	Gene names	ZNF645
Domain Architecture	No domain graphic available
Description	Zinc finger protein 645.

BLNK_HUMAN
NC score	0.041536 (rank : 150)	θ value	5.27518 (rank : 160)
Query Neighborhood Hits	193	Target Neighborhood Hits	228	Shared Neighborhood Hits	24
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

HRX_HUMAN
NC score	0.040188 (rank : 151)	θ value	4.03905 (rank : 153)
Query Neighborhood Hits	193	Target Neighborhood Hits	825	Shared Neighborhood Hits	36
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

ATX2_MOUSE
NC score	0.039401 (rank : 152)	θ value	0.62314 (rank : 102)
Query Neighborhood Hits	193	Target Neighborhood Hits	445	Shared Neighborhood Hits	36
SwissProt Accessions	O70305, P97421	Gene names	Atxn2, Atx2, Sca2
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein homolog).

TARSH_HUMAN
NC score	0.038683 (rank : 153)	θ value	2.36792 (rank : 140)
Query Neighborhood Hits	193	Target Neighborhood Hits	768	Shared Neighborhood Hits	45
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

GAB1_MOUSE
NC score	0.038554 (rank : 154)	θ value	2.36792 (rank : 138)
Query Neighborhood Hits	193	Target Neighborhood Hits	233	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

FA47B_HUMAN
NC score	0.037203 (rank : 155)	θ value	0.365318 (rank : 98)
Query Neighborhood Hits	193	Target Neighborhood Hits	431	Shared Neighborhood Hits	29
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

SPTB2_HUMAN
NC score	0.037200 (rank : 156)	θ value	0.163984 (rank : 89)
Query Neighborhood Hits	193	Target Neighborhood Hits	748	Shared Neighborhood Hits	26
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

OSBL9_HUMAN
NC score	0.037030 (rank : 157)	θ value	3.0926 (rank : 148)
Query Neighborhood Hits	193	Target Neighborhood Hits	138	Shared Neighborhood Hits	21
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

K1914_HUMAN
NC score	0.036209 (rank : 158)	θ value	5.27518 (rank : 166)
Query Neighborhood Hits	193	Target Neighborhood Hits	255	Shared Neighborhood Hits	19
SwissProt Accessions	Q8N4X5, Q8TB54, Q96PX4, Q96SY5	Gene names	KIAA1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

NCOA6_MOUSE
NC score	0.036046 (rank : 159)	θ value	4.03905 (rank : 156)
Query Neighborhood Hits	193	Target Neighborhood Hits	1076	Shared Neighborhood Hits	47
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

RIN3_MOUSE
NC score	0.035816 (rank : 160)	θ value	1.81305 (rank : 130)
Query Neighborhood Hits	193	Target Neighborhood Hits	239	Shared Neighborhood Hits	32
SwissProt Accessions	P59729	Gene names	Rin3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

SOX13_HUMAN
NC score	0.034691 (rank : 161)	θ value	5.27518 (rank : 169)
Query Neighborhood Hits	193	Target Neighborhood Hits	464	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UN79, O95275, O95826, Q9UHW7	Gene names	SOX13
Domain Architecture
Description	SOX-13 protein (Type 1 diabetes autoantigen ICA12) (Islet cell antigen 12).

SPTB2_MOUSE
NC score	0.034554 (rank : 162)	θ value	0.21417 (rank : 91)
Query Neighborhood Hits	193	Target Neighborhood Hits	770	Shared Neighborhood Hits	26
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

WHRN_HUMAN
NC score	0.034259 (rank : 163)	θ value	4.03905 (rank : 158)
Query Neighborhood Hits	193	Target Neighborhood Hits	325	Shared Neighborhood Hits	21
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

IRS1_HUMAN
NC score	0.034154 (rank : 164)	θ value	0.62314 (rank : 104)
Query Neighborhood Hits	193	Target Neighborhood Hits	109	Shared Neighborhood Hits	13
SwissProt Accessions	P35568	Gene names	IRS1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

SPTN4_HUMAN
NC score	0.033651 (rank : 165)	θ value	0.813845 (rank : 110)
Query Neighborhood Hits	193	Target Neighborhood Hits	570	Shared Neighborhood Hits	28
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

IRS1_MOUSE
NC score	0.033572 (rank : 166)	θ value	0.62314 (rank : 105)
Query Neighborhood Hits	193	Target Neighborhood Hits	112	Shared Neighborhood Hits	10
SwissProt Accessions	P35569	Gene names	Irs1, Irs-1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

RIN3_HUMAN
NC score	0.033475 (rank : 167)	θ value	1.81305 (rank : 129)
Query Neighborhood Hits	193	Target Neighborhood Hits	227	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TB24, Q8NF30, Q8TEE8, Q8WYP4, Q9H6A5, Q9HAG1	Gene names	RIN3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

GAB1_HUMAN
NC score	0.031401 (rank : 168)	θ value	0.813845 (rank : 107)
Query Neighborhood Hits	193	Target Neighborhood Hits	279	Shared Neighborhood Hits	23
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

CIC_HUMAN
NC score	0.030355 (rank : 169)	θ value	0.279714 (rank : 93)
Query Neighborhood Hits	193	Target Neighborhood Hits	992	Shared Neighborhood Hits	48
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

LNK_HUMAN
NC score	0.028707 (rank : 170)	θ value	3.0926 (rank : 147)
Query Neighborhood Hits	193	Target Neighborhood Hits	151	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

ECM1_MOUSE
NC score	0.028243 (rank : 171)	θ value	0.62314 (rank : 103)
Query Neighborhood Hits	193	Target Neighborhood Hits	105	Shared Neighborhood Hits	6
SwissProt Accessions	Q61508	Gene names	Ecm1
Domain Architecture
Description	Extracellular matrix protein 1 precursor (Secretory component p85).

ARI1B_HUMAN
NC score	0.026559 (rank : 172)	θ value	4.03905 (rank : 150)
Query Neighborhood Hits	193	Target Neighborhood Hits	567	Shared Neighborhood Hits	33
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

CD2_HUMAN
NC score	0.025693 (rank : 173)	θ value	1.38821 (rank : 117)
Query Neighborhood Hits	193	Target Neighborhood Hits	504	Shared Neighborhood Hits	25
SwissProt Accessions	P06729, Q96TE5	Gene names	CD2
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Erythrocyte receptor) (Rosette receptor).

FHOD1_HUMAN
NC score	0.025035 (rank : 174)	θ value	2.36792 (rank : 136)
Query Neighborhood Hits	193	Target Neighborhood Hits	184	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y613, Q59F76, Q6Y1F2, Q76MS8, Q8N521	Gene names	FHOD1, FHOS
Domain Architecture
Description	FH1/FH2 domain-containing protein (Formin homolog overexpressed in spleen) (FHOS) (Formin homology 2 domain-containing protein 1).

LNK_MOUSE
NC score	0.024875 (rank : 175)	θ value	4.03905 (rank : 154)
Query Neighborhood Hits	193	Target Neighborhood Hits	132	Shared Neighborhood Hits	12
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

TPM1_HUMAN
NC score	0.024566 (rank : 176)	θ value	1.81305 (rank : 131)
Query Neighborhood Hits	193	Target Neighborhood Hits	716	Shared Neighborhood Hits	17
SwissProt Accessions	P09493, P09494, P10469, Q86W64, Q96IK2, Q9UCY9	Gene names	TPM1, TMSA
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

TPM1_MOUSE
NC score	0.024478 (rank : 177)	θ value	1.81305 (rank : 132)
Query Neighborhood Hits	193	Target Neighborhood Hits	729	Shared Neighborhood Hits	17
SwissProt Accessions	P58771, P02558, P19354, P46902, P99034	Gene names	Tpm1, Tpm-1, Tpma
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

SOX13_MOUSE
NC score	0.024460 (rank : 178)	θ value	6.88961 (rank : 182)
Query Neighborhood Hits	193	Target Neighborhood Hits	495	Shared Neighborhood Hits	25
SwissProt Accessions	Q04891, Q922L3	Gene names	Sox13, Sox-13
Domain Architecture
Description	SOX-13 protein.

JIP1_HUMAN
NC score	0.024381 (rank : 179)	θ value	5.27518 (rank : 165)
Query Neighborhood Hits	193	Target Neighborhood Hits	271	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

ANK2_HUMAN
NC score	0.024212 (rank : 180)	θ value	1.06291 (rank : 112)
Query Neighborhood Hits	193	Target Neighborhood Hits	1615	Shared Neighborhood Hits	57
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

G137B_HUMAN
NC score	0.024203 (rank : 181)	θ value	3.0926 (rank : 145)
Query Neighborhood Hits	193	Target Neighborhood Hits	46	Shared Neighborhood Hits	4
SwissProt Accessions	O60478	Gene names	GPR137B, TM7SF1
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR137B (Transmembrane 7 superfamily member 1).

MCPH1_MOUSE
NC score	0.024076 (rank : 182)	θ value	1.06291 (rank : 115)
Query Neighborhood Hits	193	Target Neighborhood Hits	116	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TT79, Q8BNI9, Q8C9I7	Gene names	Mcph1
Domain Architecture
Description	Microcephalin.

LR37A_HUMAN
NC score	0.023558 (rank : 183)	θ value	4.03905 (rank : 155)
Query Neighborhood Hits	193	Target Neighborhood Hits	720	Shared Neighborhood Hits	37
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

MKL1_MOUSE
NC score	0.023331 (rank : 184)	θ value	6.88961 (rank : 179)
Query Neighborhood Hits	193	Target Neighborhood Hits	667	Shared Neighborhood Hits	31
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

MAP1A_HUMAN
NC score	0.023190 (rank : 185)	θ value	1.06291 (rank : 114)
Query Neighborhood Hits	193	Target Neighborhood Hits	1626	Shared Neighborhood Hits	56
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

ETV3_HUMAN
NC score	0.022893 (rank : 186)	θ value	1.81305 (rank : 125)
Query Neighborhood Hits	193	Target Neighborhood Hits	312	Shared Neighborhood Hits	16
SwissProt Accessions	P41162, Q8TAC8, Q9BX30	Gene names	ETV3, METS, PE1
Domain Architecture	No domain graphic available
Description	ETS translocation variant 3 (ETS-domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor).

MADCA_MOUSE
NC score	0.021940 (rank : 187)	θ value	2.36792 (rank : 139)
Query Neighborhood Hits	193	Target Neighborhood Hits	56	Shared Neighborhood Hits	6
SwissProt Accessions	Q61826, O35530, Q61278, Q64275, Q8R1M6	Gene names	Madcam1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (mMAdCAM-1).

MYO15_HUMAN
NC score	0.021737 (rank : 188)	θ value	0.279714 (rank : 95)
Query Neighborhood Hits	193	Target Neighborhood Hits	671	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

CEND1_MOUSE
NC score	0.021641 (rank : 189)	θ value	2.36792 (rank : 134)
Query Neighborhood Hits	193	Target Neighborhood Hits	260	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CRIS2_MOUSE
NC score	0.021469 (rank : 190)	θ value	5.27518 (rank : 162)
Query Neighborhood Hits	193	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	P16563	Gene names	Crisp2, Tpx-1, Tpx1
Domain Architecture
Description	Cysteine-rich secretory protein 2 precursor (CRISP-2) (Testis-specific protein TPX-1).

SHC1_MOUSE
NC score	0.020610 (rank : 191)	θ value	1.38821 (rank : 120)
Query Neighborhood Hits	193	Target Neighborhood Hits	180	Shared Neighborhood Hits	14
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

TPM3_HUMAN
NC score	0.020241 (rank : 192)	θ value	1.38821 (rank : 121)
Query Neighborhood Hits	193	Target Neighborhood Hits	689	Shared Neighborhood Hits	19
SwissProt Accessions	P06753, P12324, Q969Q2, Q9NQH8	Gene names	TPM3
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma) (hTM5).

TPM3_MOUSE
NC score	0.020036 (rank : 193)	θ value	1.38821 (rank : 122)
Query Neighborhood Hits	193	Target Neighborhood Hits	676	Shared Neighborhood Hits	18
SwissProt Accessions	P21107, Q09021, Q60606, Q80SW6, Q9EPW3	Gene names	Tpm3, Tpm-5, Tpm5
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma).

SMR2A_MOUSE
NC score	0.019429 (rank : 194)	θ value	8.99809 (rank : 192)
Query Neighborhood Hits	193	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	O09133	Gene names	Smr2, Msg2, Vcs2
Domain Architecture	No domain graphic available
Description	Submaxillary gland androgen-regulated protein 2, isoform alpha precursor (Salivary protein MSG2, isoform alpha).

CNKR2_MOUSE
NC score	0.018912 (rank : 195)	θ value	8.99809 (rank : 186)
Query Neighborhood Hits	193	Target Neighborhood Hits	197	Shared Neighborhood Hits	17
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.018660 (rank : 196)	θ value	8.99809 (rank : 185)
Query Neighborhood Hits	193	Target Neighborhood Hits	197	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CD248_HUMAN
NC score	0.018335 (rank : 197)	θ value	6.88961 (rank : 174)
Query Neighborhood Hits	193	Target Neighborhood Hits	679	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HCU0, Q3SX55, Q96KB6	Gene names	CD248, CD164L1, TEM1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

EP15_HUMAN
NC score	0.018292 (rank : 198)	θ value	1.06291 (rank : 113)
Query Neighborhood Hits	193	Target Neighborhood Hits	1021	Shared Neighborhood Hits	24
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

JIP1_MOUSE
NC score	0.018076 (rank : 199)	θ value	8.99809 (rank : 188)
Query Neighborhood Hits	193	Target Neighborhood Hits	259	Shared Neighborhood Hits	19
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

PDLI7_HUMAN
NC score	0.018060 (rank : 200)	θ value	4.03905 (rank : 157)
Query Neighborhood Hits	193	Target Neighborhood Hits	547	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

TNR4_HUMAN
NC score	0.017777 (rank : 201)	θ value	0.813845 (rank : 111)
Query Neighborhood Hits	193	Target Neighborhood Hits	152	Shared Neighborhood Hits	4
SwissProt Accessions	P43489, Q13663, Q5T7M0	Gene names	TNFRSF4, TXGP1L
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 4 precursor (OX40L receptor) (ACT35 antigen) (TAX transcriptionally-activated glycoprotein 1 receptor) (CD134 antigen).

GLTP_MOUSE
NC score	0.017616 (rank : 202)	θ value	4.03905 (rank : 152)
Query Neighborhood Hits	193	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JL62, Q91YJ7, Q9CTK9	Gene names	Gltp
Domain Architecture	No domain graphic available
Description	Glycolipid transfer protein (GLTP).

ZCPW1_MOUSE
NC score	0.017529 (rank : 203)	θ value	3.0926 (rank : 149)
Query Neighborhood Hits	193	Target Neighborhood Hits	307	Shared Neighborhood Hits	13
SwissProt Accessions	Q6IR42	Gene names	Zcwpw1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1 homolog.

TRI66_HUMAN
NC score	0.016911 (rank : 204)	θ value	5.27518 (rank : 170)
Query Neighborhood Hits	193	Target Neighborhood Hits	479	Shared Neighborhood Hits	25
SwissProt Accessions	O15016, Q9BQQ4	Gene names	TRIM66, KIAA0298
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

PHLB1_HUMAN
NC score	0.016797 (rank : 205)	θ value	1.81305 (rank : 128)
Query Neighborhood Hits	193	Target Neighborhood Hits	1038	Shared Neighborhood Hits	46
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

UBP53_MOUSE
NC score	0.016354 (rank : 206)	θ value	5.27518 (rank : 171)
Query Neighborhood Hits	193	Target Neighborhood Hits	188	Shared Neighborhood Hits	9
SwissProt Accessions	P15975, Q8CB37, Q8R251	Gene names	Usp53, Phxr3
Domain Architecture	No domain graphic available
Description	Inactive ubiquitin carboxyl-terminal hydrolase 53 (Inactive ubiquitin- specific peptidase 53) (Per-hexamer repeat protein 3).

AKAP1_MOUSE
NC score	0.016301 (rank : 207)	θ value	3.0926 (rank : 142)
Query Neighborhood Hits	193	Target Neighborhood Hits	198	Shared Neighborhood Hits	14
SwissProt Accessions	O08715, O08714, P97488	Gene names	Akap1, Akap
Domain Architecture
Description	A kinase anchor protein 1, mitochondrial precursor (Protein kinase A- anchoring protein 1) (PRKA1) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Spermatid A-kinase anchor protein) (S-AKAP).

BAZ2A_MOUSE
NC score	0.015959 (rank : 208)	θ value	2.36792 (rank : 133)
Query Neighborhood Hits	193	Target Neighborhood Hits	744	Shared Neighborhood Hits	26
SwissProt Accessions	Q91YE5	Gene names	Baz2a, Tip5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5).

CB029_HUMAN
NC score	0.015822 (rank : 209)	θ value	6.88961 (rank : 172)
Query Neighborhood Hits	193	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UKZ1, Q6P2M9, Q8N681	Gene names	C2orf29
Domain Architecture	No domain graphic available
Description	Protein C2orf29.

CB029_MOUSE
NC score	0.015702 (rank : 210)	θ value	6.88961 (rank : 173)
Query Neighborhood Hits	193	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CWN7, Q3TJG9	Gene names	D1Bwg0212e
Domain Architecture	No domain graphic available
Description	Protein C2orf29 homolog.

MYO15_MOUSE
NC score	0.015617 (rank : 211)	θ value	1.81305 (rank : 126)
Query Neighborhood Hits	193	Target Neighborhood Hits	467	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

ANR11_HUMAN
NC score	0.015334 (rank : 212)	θ value	0.365318 (rank : 97)
Query Neighborhood Hits	193	Target Neighborhood Hits	1289	Shared Neighborhood Hits	30
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

AZI1_MOUSE
NC score	0.015142 (rank : 213)	θ value	0.47712 (rank : 100)
Query Neighborhood Hits	193	Target Neighborhood Hits	990	Shared Neighborhood Hits	21
SwissProt Accessions	Q62036	Gene names	Azi1, Az1, Azi
Domain Architecture
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1).

SCEL_MOUSE
NC score	0.014538 (rank : 214)	θ value	5.27518 (rank : 168)
Query Neighborhood Hits	193	Target Neighborhood Hits	89	Shared Neighborhood Hits	7
SwissProt Accessions	Q9EQG3, Q9CTT9	Gene names	Scel
Domain Architecture
Description	Sciellin.

IRBP_HUMAN
NC score	0.014405 (rank : 215)	θ value	6.88961 (rank : 177)
Query Neighborhood Hits	193	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	P10745	Gene names	RBP3
Domain Architecture
Description	Interphotoreceptor retinoid-binding protein precursor (IRBP) (Interstitial retinol-binding protein).

IRBP_MOUSE
NC score	0.014335 (rank : 216)	θ value	6.88961 (rank : 178)
Query Neighborhood Hits	193	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	P49194, Q6B4R6, Q8VD34, Q9R0H8	Gene names	Rbp3
Domain Architecture	No domain graphic available
Description	Interphotoreceptor retinoid-binding protein precursor (IRBP) (Interstitial retinol-binding protein).

DLG5_HUMAN
NC score	0.014308 (rank : 217)	θ value	2.36792 (rank : 135)
Query Neighborhood Hits	193	Target Neighborhood Hits	1088	Shared Neighborhood Hits	35
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

CEND1_HUMAN
NC score	0.013898 (rank : 218)	θ value	5.27518 (rank : 161)
Query Neighborhood Hits	193	Target Neighborhood Hits	284	Shared Neighborhood Hits	17
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CBL_MOUSE
NC score	0.013753 (rank : 219)	θ value	3.0926 (rank : 143)
Query Neighborhood Hits	193	Target Neighborhood Hits	426	Shared Neighborhood Hits	21
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

DOK2_MOUSE
NC score	0.012971 (rank : 220)	θ value	3.0926 (rank : 144)
Query Neighborhood Hits	193	Target Neighborhood Hits	244	Shared Neighborhood Hits	12
SwissProt Accessions	O70469, O70272, Q99KL1	Gene names	Dok2, Frip
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) (Dok- related protein) (Dok-R) (IL-four receptor-interacting protein) (FRIP).

RM49_MOUSE
NC score	0.011921 (rank : 221)	θ value	8.99809 (rank : 191)
Query Neighborhood Hits	193	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CQ40, Q3UC21, Q8C5R0, Q8C7P3	Gene names	Mrpl49
Domain Architecture
Description	Mitochondrial 39S ribosomal protein L49 (L49mt) (MRP-L49).

PASK_HUMAN
NC score	0.010628 (rank : 222)	θ value	0.365318 (rank : 99)
Query Neighborhood Hits	193	Target Neighborhood Hits	857	Shared Neighborhood Hits	9
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

AHTF1_MOUSE
NC score	0.009771 (rank : 223)	θ value	8.99809 (rank : 184)
Query Neighborhood Hits	193	Target Neighborhood Hits	176	Shared Neighborhood Hits	12
SwissProt Accessions	Q8CJF7, Q8BVJ5, Q8VD55	Gene names	Ahctf1, Elys
Domain Architecture	No domain graphic available
Description	AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac).

CAC1G_HUMAN
NC score	0.009712 (rank : 224)	θ value	4.03905 (rank : 151)
Query Neighborhood Hits	193	Target Neighborhood Hits	587	Shared Neighborhood Hits	27
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

GOGB1_HUMAN
NC score	0.008594 (rank : 225)	θ value	5.27518 (rank : 163)
Query Neighborhood Hits	193	Target Neighborhood Hits	2297	Shared Neighborhood Hits	36
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

STON2_HUMAN
NC score	0.008123 (rank : 226)	θ value	6.88961 (rank : 183)
Query Neighborhood Hits	193	Target Neighborhood Hits	115	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WXE9, Q6NT47, Q96RI7, Q96RU6	Gene names	STON2, STN2, STNB
Domain Architecture
Description	Stonin-2 (Stoned B).

PASK_MOUSE
NC score	0.007914 (rank : 227)	θ value	1.38821 (rank : 119)
Query Neighborhood Hits	193	Target Neighborhood Hits	867	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

PO6F1_MOUSE
NC score	0.007593 (rank : 228)	θ value	8.99809 (rank : 190)
Query Neighborhood Hits	193	Target Neighborhood Hits	581	Shared Neighborhood Hits	23
SwissProt Accessions	Q07916, Q91XK3	Gene names	Pou6f1, Emb
Domain Architecture
Description	POU domain, class 6, transcription factor 1 (Octamer-binding transcription factor EMB) (Transcription regulatory protein MCP-1).

ETV1_HUMAN
NC score	0.007419 (rank : 229)	θ value	6.88961 (rank : 175)
Query Neighborhood Hits	193	Target Neighborhood Hits	107	Shared Neighborhood Hits	8
SwissProt Accessions	P50549, O75849, Q9UQ71, Q9Y636	Gene names	ETV1, ER81
Domain Architecture
Description	ETS translocation variant 1 (ER81 protein).

ETV1_MOUSE
NC score	0.007115 (rank : 230)	θ value	6.88961 (rank : 176)
Query Neighborhood Hits	193	Target Neighborhood Hits	92	Shared Neighborhood Hits	6
SwissProt Accessions	P41164	Gene names	Etv1, Er81, Etsrp81
Domain Architecture
Description	ETS translocation variant 1 (ER81 protein).

DCC_MOUSE
NC score	0.006915 (rank : 231)	θ value	1.81305 (rank : 124)
Query Neighborhood Hits	193	Target Neighborhood Hits	896	Shared Neighborhood Hits	23
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

NECD_MOUSE
NC score	0.005381 (rank : 232)	θ value	5.27518 (rank : 167)
Query Neighborhood Hits	193	Target Neighborhood Hits	85	Shared Neighborhood Hits	9
SwissProt Accessions	P25233, Q542W7, Q61951	Gene names	Ndn
Domain Architecture
Description	Necdin.

ACK1_MOUSE
NC score	0.003753 (rank : 233)	θ value	1.81305 (rank : 123)
Query Neighborhood Hits	193	Target Neighborhood Hits	1080	Shared Neighborhood Hits	43
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

FOG1_MOUSE
NC score	0.002816 (rank : 234)	θ value	2.36792 (rank : 137)
Query Neighborhood Hits	193	Target Neighborhood Hits	1237	Shared Neighborhood Hits	33
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

HXB3_HUMAN
NC score	0.002180 (rank : 235)	θ value	3.0926 (rank : 146)
Query Neighborhood Hits	193	Target Neighborhood Hits	559	Shared Neighborhood Hits	16
SwissProt Accessions	P14651, O95615, P17484	Gene names	HOXB3, HOX2G
Domain Architecture
Description	Homeobox protein Hox-B3 (Hox-2G) (Hox-2.7).

ULK1_MOUSE
NC score	0.001295 (rank : 236)	θ value	2.36792 (rank : 141)
Query Neighborhood Hits	193	Target Neighborhood Hits	1214	Shared Neighborhood Hits	29
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

NRP2_HUMAN
NC score	0.000818 (rank : 237)	θ value	8.99809 (rank : 189)
Query Neighborhood Hits	193	Target Neighborhood Hits	120	Shared Neighborhood Hits	2
SwissProt Accessions	O60462, O14820, O14821	Gene names	NRP2, VEGF165R2
Domain Architecture
Description	Neuropilin-2 precursor (Vascular endothelial cell growth factor 165 receptor 2).

FBLN2_HUMAN
NC score	-0.000646 (rank : 238)	θ value	8.99809 (rank : 187)
Query Neighborhood Hits	193	Target Neighborhood Hits	392	Shared Neighborhood Hits	7
SwissProt Accessions	P98095	Gene names	FBLN2
Domain Architecture
Description	Fibulin-2 precursor.

GP176_MOUSE
NC score	-0.000807 (rank : 239)	θ value	5.27518 (rank : 164)
Query Neighborhood Hits	193	Target Neighborhood Hits	539	Shared Neighborhood Hits	2
SwissProt Accessions	Q80WT4, Q80UC4	Gene names	Gpr176, Agr9, Gm1012
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 176 (G-protein coupled receptor AGR9).