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Network neighborhood for query Sequence : PKHF2_MOUSE

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PKHF2_MOUSE
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PKHF2_MOUSE
θ value	5.41814e-138 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	77	Target Neighborhood Hits	77	Shared Neighborhood Hits	77
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHF2_HUMAN
θ value	1.12976e-135 (rank : 2)	NC score	0.999710 (rank : 2)
Query Neighborhood Hits	77	Target Neighborhood Hits	75	Shared Neighborhood Hits	74
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF1_HUMAN
θ value	5.33382e-77 (rank : 3)	NC score	0.982650 (rank : 3)
Query Neighborhood Hits	77	Target Neighborhood Hits	76	Shared Neighborhood Hits	64
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
θ value	2.24094e-75 (rank : 4)	NC score	0.980578 (rank : 4)
Query Neighborhood Hits	77	Target Neighborhood Hits	80	Shared Neighborhood Hits	65
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

FGD6_HUMAN
θ value	4.57862e-28 (rank : 5)	NC score	0.733211 (rank : 5)
Query Neighborhood Hits	77	Target Neighborhood Hits	237	Shared Neighborhood Hits	64
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	1.37858e-24 (rank : 6)	NC score	0.717377 (rank : 7)
Query Neighborhood Hits	77	Target Neighborhood Hits	282	Shared Neighborhood Hits	63
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD4_HUMAN
θ value	5.60996e-18 (rank : 7)	NC score	0.634891 (rank : 17)
Query Neighborhood Hits	77	Target Neighborhood Hits	219	Shared Neighborhood Hits	65
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD2_HUMAN
θ value	3.63628e-17 (rank : 8)	NC score	0.653246 (rank : 16)
Query Neighborhood Hits	77	Target Neighborhood Hits	151	Shared Neighborhood Hits	63
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD1_MOUSE
θ value	1.38178e-16 (rank : 9)	NC score	0.619946 (rank : 20)
Query Neighborhood Hits	77	Target Neighborhood Hits	387	Shared Neighborhood Hits	60
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_HUMAN
θ value	1.80466e-16 (rank : 10)	NC score	0.623435 (rank : 19)
Query Neighborhood Hits	77	Target Neighborhood Hits	367	Shared Neighborhood Hits	61
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_MOUSE
θ value	1.80466e-16 (rank : 11)	NC score	0.658198 (rank : 15)
Query Neighborhood Hits	77	Target Neighborhood Hits	163	Shared Neighborhood Hits	64
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD4_MOUSE
θ value	5.25075e-16 (rank : 12)	NC score	0.630118 (rank : 18)
Query Neighborhood Hits	77	Target Neighborhood Hits	227	Shared Neighborhood Hits	67
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD5_MOUSE
θ value	1.68911e-14 (rank : 13)	NC score	0.715581 (rank : 8)
Query Neighborhood Hits	77	Target Neighborhood Hits	170	Shared Neighborhood Hits	59
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FGD5_HUMAN
θ value	1.86753e-13 (rank : 14)	NC score	0.705731 (rank : 10)
Query Neighborhood Hits	77	Target Neighborhood Hits	235	Shared Neighborhood Hits	57
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

RUFY2_HUMAN
θ value	1.2105e-12 (rank : 15)	NC score	0.333812 (rank : 42)
Query Neighborhood Hits	77	Target Neighborhood Hits	1208	Shared Neighborhood Hits	50
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

RUFY1_HUMAN
θ value	2.0648e-12 (rank : 16)	NC score	0.413831 (rank : 38)
Query Neighborhood Hits	77	Target Neighborhood Hits	848	Shared Neighborhood Hits	51
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

RUFY1_MOUSE
θ value	3.52202e-12 (rank : 17)	NC score	0.419499 (rank : 35)
Query Neighborhood Hits	77	Target Neighborhood Hits	765	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY2_MOUSE
θ value	4.59992e-12 (rank : 18)	NC score	0.419807 (rank : 34)
Query Neighborhood Hits	77	Target Neighborhood Hits	820	Shared Neighborhood Hits	50
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

ZFYV9_HUMAN
θ value	4.59992e-12 (rank : 19)	NC score	0.685663 (rank : 12)
Query Neighborhood Hits	77	Target Neighborhood Hits	134	Shared Neighborhood Hits	49
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

ZFY16_HUMAN
θ value	7.84624e-12 (rank : 20)	NC score	0.659670 (rank : 14)
Query Neighborhood Hits	77	Target Neighborhood Hits	125	Shared Neighborhood Hits	48
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

EEA1_HUMAN
θ value	1.33837e-11 (rank : 21)	NC score	0.233109 (rank : 54)
Query Neighborhood Hits	77	Target Neighborhood Hits	1796	Shared Neighborhood Hits	51
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

EEA1_MOUSE
θ value	1.33837e-11 (rank : 22)	NC score	0.251571 (rank : 52)
Query Neighborhood Hits	77	Target Neighborhood Hits	1637	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

ZFY16_MOUSE
θ value	1.33837e-11 (rank : 23)	NC score	0.669972 (rank : 13)
Query Neighborhood Hits	77	Target Neighborhood Hits	108	Shared Neighborhood Hits	48
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY28_HUMAN
θ value	2.52405e-10 (rank : 24)	NC score	0.728674 (rank : 6)
Query Neighborhood Hits	77	Target Neighborhood Hits	152	Shared Neighborhood Hits	48
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

FARP1_HUMAN
θ value	1.25267e-09 (rank : 25)	NC score	0.318665 (rank : 45)
Query Neighborhood Hits	77	Target Neighborhood Hits	241	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

MTMR3_HUMAN
θ value	2.13673e-09 (rank : 26)	NC score	0.402971 (rank : 39)
Query Neighborhood Hits	77	Target Neighborhood Hits	163	Shared Neighborhood Hits	48
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

HGS_MOUSE
θ value	4.76016e-09 (rank : 27)	NC score	0.543114 (rank : 25)
Query Neighborhood Hits	77	Target Neighborhood Hits	589	Shared Neighborhood Hits	49
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

WDFY1_HUMAN
θ value	6.21693e-09 (rank : 28)	NC score	0.439190 (rank : 31)
Query Neighborhood Hits	77	Target Neighborhood Hits	305	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

FARP2_HUMAN
θ value	8.11959e-09 (rank : 29)	NC score	0.323875 (rank : 43)
Query Neighborhood Hits	77	Target Neighborhood Hits	240	Shared Neighborhood Hits	30
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
θ value	8.11959e-09 (rank : 30)	NC score	0.322777 (rank : 44)
Query Neighborhood Hits	77	Target Neighborhood Hits	209	Shared Neighborhood Hits	31
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ANFY1_MOUSE
θ value	1.06045e-08 (rank : 31)	NC score	0.277581 (rank : 46)
Query Neighborhood Hits	77	Target Neighborhood Hits	480	Shared Neighborhood Hits	48
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_HUMAN
θ value	1.38499e-08 (rank : 32)	NC score	0.277565 (rank : 47)
Query Neighborhood Hits	77	Target Neighborhood Hits	480	Shared Neighborhood Hits	48
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

FGD3_HUMAN
θ value	1.38499e-08 (rank : 33)	NC score	0.574849 (rank : 23)
Query Neighborhood Hits	77	Target Neighborhood Hits	249	Shared Neighborhood Hits	57
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

HGS_HUMAN
θ value	1.38499e-08 (rank : 34)	NC score	0.545147 (rank : 24)
Query Neighborhood Hits	77	Target Neighborhood Hits	517	Shared Neighborhood Hits	49
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

FYV1_HUMAN
θ value	1.17247e-07 (rank : 35)	NC score	0.491018 (rank : 27)
Query Neighborhood Hits	77	Target Neighborhood Hits	217	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	1.17247e-07 (rank : 36)	NC score	0.490406 (rank : 29)
Query Neighborhood Hits	77	Target Neighborhood Hits	191	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

ZFYV1_HUMAN
θ value	1.53129e-07 (rank : 37)	NC score	0.581649 (rank : 21)
Query Neighborhood Hits	77	Target Neighborhood Hits	166	Shared Neighborhood Hits	48
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFY21_MOUSE
θ value	1.99992e-07 (rank : 38)	NC score	0.708507 (rank : 9)
Query Neighborhood Hits	77	Target Neighborhood Hits	72	Shared Neighborhood Hits	48
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFYV1_MOUSE
θ value	1.99992e-07 (rank : 39)	NC score	0.577852 (rank : 22)
Query Neighborhood Hits	77	Target Neighborhood Hits	153	Shared Neighborhood Hits	48
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

WDFY2_MOUSE
θ value	5.81887e-07 (rank : 40)	NC score	0.418158 (rank : 36)
Query Neighborhood Hits	77	Target Neighborhood Hits	337	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

FYCO1_HUMAN
θ value	7.59969e-07 (rank : 41)	NC score	0.265873 (rank : 49)
Query Neighborhood Hits	77	Target Neighborhood Hits	1149	Shared Neighborhood Hits	51
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

WDFY2_HUMAN
θ value	9.92553e-07 (rank : 42)	NC score	0.414357 (rank : 37)
Query Neighborhood Hits	77	Target Neighborhood Hits	332	Shared Neighborhood Hits	48
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

ZFY21_HUMAN
θ value	9.92553e-07 (rank : 43)	NC score	0.703845 (rank : 11)
Query Neighborhood Hits	77	Target Neighborhood Hits	72	Shared Neighborhood Hits	48
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

WDFY3_HUMAN
θ value	1.29631e-06 (rank : 44)	NC score	0.387596 (rank : 41)
Query Neighborhood Hits	77	Target Neighborhood Hits	348	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY3_MOUSE
θ value	1.29631e-06 (rank : 45)	NC score	0.388759 (rank : 40)
Query Neighborhood Hits	77	Target Neighborhood Hits	332	Shared Neighborhood Hits	48
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

FGD3_MOUSE
θ value	1.69304e-06 (rank : 46)	NC score	0.532722 (rank : 26)
Query Neighborhood Hits	77	Target Neighborhood Hits	257	Shared Neighborhood Hits	62
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

ALS2_MOUSE
θ value	1.09739e-05 (rank : 47)	NC score	0.208899 (rank : 57)
Query Neighborhood Hits	77	Target Neighborhood Hits	111	Shared Neighborhood Hits	20
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

ALS2_HUMAN
θ value	2.44474e-05 (rank : 48)	NC score	0.196619 (rank : 58)
Query Neighborhood Hits	77	Target Neighborhood Hits	121	Shared Neighborhood Hits	20
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

RBNS5_HUMAN
θ value	9.29e-05 (rank : 49)	NC score	0.491011 (rank : 28)
Query Neighborhood Hits	77	Target Neighborhood Hits	242	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	0.00020696 (rank : 50)	NC score	0.484775 (rank : 30)
Query Neighborhood Hits	77	Target Neighborhood Hits	266	Shared Neighborhood Hits	49
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

FYCO1_MOUSE
θ value	0.000461057 (rank : 51)	NC score	0.238747 (rank : 53)
Query Neighborhood Hits	77	Target Neighborhood Hits	1059	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

PREX1_HUMAN
θ value	0.00175202 (rank : 52)	NC score	0.268890 (rank : 48)
Query Neighborhood Hits	77	Target Neighborhood Hits	177	Shared Neighborhood Hits	25
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ZFY19_HUMAN
θ value	0.0252991 (rank : 53)	NC score	0.431930 (rank : 32)
Query Neighborhood Hits	77	Target Neighborhood Hits	206	Shared Neighborhood Hits	46
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

SWP70_HUMAN
θ value	0.0431538 (rank : 54)	NC score	0.108263 (rank : 100)
Query Neighborhood Hits	77	Target Neighborhood Hits	973	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

ZFY19_MOUSE
θ value	0.0431538 (rank : 55)	NC score	0.425760 (rank : 33)
Query Neighborhood Hits	77	Target Neighborhood Hits	143	Shared Neighborhood Hits	48
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

S4A7_HUMAN
θ value	0.0736092 (rank : 56)	NC score	0.057925 (rank : 132)
Query Neighborhood Hits	77	Target Neighborhood Hits	55	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y6M7, O60350, Q6AHZ9, Q9HC88, Q9UIB9	Gene names	SLC4A7, BT, NBC2, NBC2B, NBC3, SBC2, SLC4A6
Domain Architecture	No domain graphic available
Description	Sodium bicarbonate cotransporter 3 (Sodium bicarbonate cotransporter 2) (Sodium bicarbonate cotransporter 2b) (Bicarbonate transporter) (Solute carrier family 4 member 7).

S4A7_MOUSE
θ value	0.0736092 (rank : 57)	NC score	0.060273 (rank : 131)
Query Neighborhood Hits	77	Target Neighborhood Hits	30	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BTY2, Q3U5H7	Gene names	Slc4a7, Nbc3
Domain Architecture	No domain graphic available
Description	Sodium bicarbonate cotransporter 3 (Solute carrier family 4 member 7).

SWP70_MOUSE
θ value	0.0736092 (rank : 58)	NC score	0.102379 (rank : 102)
Query Neighborhood Hits	77	Target Neighborhood Hits	1097	Shared Neighborhood Hits	33
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

CYH4_MOUSE
θ value	0.163984 (rank : 59)	NC score	0.063626 (rank : 128)
Query Neighborhood Hits	77	Target Neighborhood Hits	134	Shared Neighborhood Hits	21
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

S4A10_HUMAN
θ value	0.279714 (rank : 60)	NC score	0.051842 (rank : 137)
Query Neighborhood Hits	77	Target Neighborhood Hits	33	Shared Neighborhood Hits	8
SwissProt Accessions	Q6U841, Q4ZFX6, Q8TCP2, Q9HCQ6	Gene names	SLC4A10, NCBE
Domain Architecture	No domain graphic available
Description	Sodium-driven chloride bicarbonate exchanger (Solute carrier family 4 member 10).

S4A10_MOUSE
θ value	0.279714 (rank : 61)	NC score	0.052092 (rank : 136)
Query Neighborhood Hits	77	Target Neighborhood Hits	23	Shared Neighborhood Hits	8
SwissProt Accessions	Q5DTL9, Q8CFS3, Q9EST0	Gene names	Slc4a10, Kiaa4136, Ncbe
Domain Architecture	No domain graphic available
Description	Sodium-driven chloride bicarbonate exchanger (Solute carrier family 4 member 10).

TRI32_HUMAN
θ value	0.813845 (rank : 62)	NC score	0.033675 (rank : 143)
Query Neighborhood Hits	77	Target Neighborhood Hits	264	Shared Neighborhood Hits	9
SwissProt Accessions	Q13049, Q9NQP8	Gene names	TRIM32, HT2A
Domain Architecture
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-) (Zinc finger protein HT2A) (72 kDa Tat-interacting protein).

CYH4_HUMAN
θ value	1.06291 (rank : 63)	NC score	0.055470 (rank : 134)
Query Neighborhood Hits	77	Target Neighborhood Hits	135	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

TRI32_MOUSE
θ value	1.06291 (rank : 64)	NC score	0.031477 (rank : 145)
Query Neighborhood Hits	77	Target Neighborhood Hits	271	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CH72, Q8K055	Gene names	Trim32
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-).

VAV2_HUMAN
θ value	1.06291 (rank : 65)	NC score	0.096959 (rank : 106)
Query Neighborhood Hits	77	Target Neighborhood Hits	453	Shared Neighborhood Hits	20
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

CEND1_HUMAN
θ value	2.36792 (rank : 66)	NC score	0.033384 (rank : 144)
Query Neighborhood Hits	77	Target Neighborhood Hits	284	Shared Neighborhood Hits	23
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

ZDH21_MOUSE
θ value	2.36792 (rank : 67)	NC score	0.024399 (rank : 147)
Query Neighborhood Hits	77	Target Neighborhood Hits	53	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D270, Q6EMK1, Q80XQ3	Gene names	Zdhhc21, Gramp3
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC21 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 21) (DHHC-21) (GABA-A receptor-associated membrane protein 3).

EXOC8_MOUSE
θ value	3.0926 (rank : 68)	NC score	0.038478 (rank : 142)
Query Neighborhood Hits	77	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	Q6PGF7	Gene names	Exoc8
Domain Architecture	No domain graphic available
Description	Exocyst complex component 8 (Exocyst complex 84 kDa subunit).

CEND1_MOUSE
θ value	4.03905 (rank : 69)	NC score	0.030277 (rank : 146)
Query Neighborhood Hits	77	Target Neighborhood Hits	260	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

SMYD1_MOUSE
θ value	5.27518 (rank : 70)	NC score	0.013464 (rank : 149)
Query Neighborhood Hits	77	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	P97443, P97442, P97444	Gene names	Smyd1, Bop
Domain Architecture
Description	SET and MYND domain-containing protein 1 (Zinc-finger protein BOP) (m- BOP) (CD8b-opposite).

CYH2_HUMAN
θ value	6.88961 (rank : 71)	NC score	0.041754 (rank : 141)
Query Neighborhood Hits	77	Target Neighborhood Hits	175	Shared Neighborhood Hits	21
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	6.88961 (rank : 72)	NC score	0.041778 (rank : 140)
Query Neighborhood Hits	77	Target Neighborhood Hits	171	Shared Neighborhood Hits	21
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

MYRIP_MOUSE
θ value	6.88961 (rank : 73)	NC score	0.049961 (rank : 139)
Query Neighborhood Hits	77	Target Neighborhood Hits	207	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

SYTL3_MOUSE
θ value	6.88961 (rank : 74)	NC score	0.018004 (rank : 148)
Query Neighborhood Hits	77	Target Neighborhood Hits	110	Shared Neighborhood Hits	9
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

ARHG8_HUMAN
θ value	8.99809 (rank : 75)	NC score	0.110820 (rank : 99)
Query Neighborhood Hits	77	Target Neighborhood Hits	85	Shared Neighborhood Hits	18
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

CYH3_MOUSE
θ value	8.99809 (rank : 76)	NC score	0.057731 (rank : 133)
Query Neighborhood Hits	77	Target Neighborhood Hits	148	Shared Neighborhood Hits	21
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

ZDH21_HUMAN
θ value	8.99809 (rank : 77)	NC score	0.012208 (rank : 150)
Query Neighborhood Hits	77	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IVQ6, Q5VWG1	Gene names	ZDHHC21
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC21 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 21) (DHHC-21).

ABR_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.144968 (rank : 79)
Query Neighborhood Hits	77	Target Neighborhood Hits	166	Shared Neighborhood Hits	19
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ARHG1_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.124684 (rank : 86)
Query Neighborhood Hits	77	Target Neighborhood Hits	176	Shared Neighborhood Hits	15
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 80)	NC score	0.123464 (rank : 87)
Query Neighborhood Hits	77	Target Neighborhood Hits	266	Shared Neighborhood Hits	15
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.119797 (rank : 89)
Query Neighborhood Hits	77	Target Neighborhood Hits	142	Shared Neighborhood Hits	15
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.165396 (rank : 69)
Query Neighborhood Hits	77	Target Neighborhood Hits	120	Shared Neighborhood Hits	18
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG3_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.091386 (rank : 112)
Query Neighborhood Hits	77	Target Neighborhood Hits	82	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 84)	NC score	0.092767 (rank : 111)
Query Neighborhood Hits	77	Target Neighborhood Hits	85	Shared Neighborhood Hits	12
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG4_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.169262 (rank : 66)
Query Neighborhood Hits	77	Target Neighborhood Hits	242	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	θ > 10 (rank : 86)	NC score	0.169078 (rank : 67)
Query Neighborhood Hits	77	Target Neighborhood Hits	185	Shared Neighborhood Hits	16
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG5_HUMAN
θ value	θ > 10 (rank : 87)	NC score	0.186095 (rank : 60)
Query Neighborhood Hits	77	Target Neighborhood Hits	172	Shared Neighborhood Hits	18
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG6_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.083319 (rank : 118)
Query Neighborhood Hits	77	Target Neighborhood Hits	376	Shared Neighborhood Hits	13
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	θ > 10 (rank : 89)	NC score	0.074258 (rank : 122)
Query Neighborhood Hits	77	Target Neighborhood Hits	394	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG7_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.128046 (rank : 84)
Query Neighborhood Hits	77	Target Neighborhood Hits	347	Shared Neighborhood Hits	20
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
θ value	θ > 10 (rank : 91)	NC score	0.107759 (rank : 101)
Query Neighborhood Hits	77	Target Neighborhood Hits	396	Shared Neighborhood Hits	18
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG8_MOUSE
θ value	θ > 10 (rank : 92)	NC score	0.061657 (rank : 130)
Query Neighborhood Hits	77	Target Neighborhood Hits	79	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHG9_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.154629 (rank : 73)
Query Neighborhood Hits	77	Target Neighborhood Hits	235	Shared Neighborhood Hits	17
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 94)	NC score	0.152877 (rank : 74)
Query Neighborhood Hits	77	Target Neighborhood Hits	234	Shared Neighborhood Hits	17
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHGA_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.177750 (rank : 61)
Query Neighborhood Hits	77	Target Neighborhood Hits	187	Shared Neighborhood Hits	20
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 96)	NC score	0.177723 (rank : 62)
Query Neighborhood Hits	77	Target Neighborhood Hits	125	Shared Neighborhood Hits	20
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGB_HUMAN
θ value	θ > 10 (rank : 97)	NC score	0.119594 (rank : 90)
Query Neighborhood Hits	77	Target Neighborhood Hits	375	Shared Neighborhood Hits	18
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.112615 (rank : 95)
Query Neighborhood Hits	77	Target Neighborhood Hits	351	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.111481 (rank : 98)
Query Neighborhood Hits	77	Target Neighborhood Hits	344	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGF_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.163602 (rank : 71)
Query Neighborhood Hits	77	Target Neighborhood Hits	214	Shared Neighborhood Hits	18
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGG_HUMAN
θ value	θ > 10 (rank : 101)	NC score	0.173891 (rank : 64)
Query Neighborhood Hits	77	Target Neighborhood Hits	129	Shared Neighborhood Hits	18
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 102)	NC score	0.163822 (rank : 70)
Query Neighborhood Hits	77	Target Neighborhood Hits	152	Shared Neighborhood Hits	18
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

BCR_HUMAN
θ value	θ > 10 (rank : 103)	NC score	0.144674 (rank : 80)
Query Neighborhood Hits	77	Target Neighborhood Hits	204	Shared Neighborhood Hits	19
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

CJ064_HUMAN
θ value	θ > 10 (rank : 104)	NC score	0.072466 (rank : 123)
Query Neighborhood Hits	77	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZS81, Q8N4A3	Gene names	C10orf64
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf64.

CNKR1_HUMAN
θ value	θ > 10 (rank : 105)	NC score	0.055269 (rank : 135)
Query Neighborhood Hits	77	Target Neighborhood Hits	154	Shared Neighborhood Hits	16
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

DNMBP_HUMAN
θ value	θ > 10 (rank : 106)	NC score	0.081818 (rank : 119)
Query Neighborhood Hits	77	Target Neighborhood Hits	413	Shared Neighborhood Hits	19
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
θ value	θ > 10 (rank : 107)	NC score	0.086243 (rank : 116)
Query Neighborhood Hits	77	Target Neighborhood Hits	435	Shared Neighborhood Hits	16
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DUET_HUMAN
θ value	θ > 10 (rank : 108)	NC score	0.062801 (rank : 129)
Query Neighborhood Hits	77	Target Neighborhood Hits	1220	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

ECT2_HUMAN
θ value	θ > 10 (rank : 109)	NC score	0.213750 (rank : 56)
Query Neighborhood Hits	77	Target Neighborhood Hits	98	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 110)	NC score	0.219127 (rank : 55)
Query Neighborhood Hits	77	Target Neighborhood Hits	98	Shared Neighborhood Hits	19
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

GNRP_HUMAN
θ value	θ > 10 (rank : 111)	NC score	0.148639 (rank : 78)
Query Neighborhood Hits	77	Target Neighborhood Hits	239	Shared Neighborhood Hits	25
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 112)	NC score	0.158162 (rank : 72)
Query Neighborhood Hits	77	Target Neighborhood Hits	191	Shared Neighborhood Hits	25
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

HAPIP_HUMAN
θ value	θ > 10 (rank : 113)	NC score	0.166631 (rank : 68)
Query Neighborhood Hits	77	Target Neighborhood Hits	350	Shared Neighborhood Hits	26
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ITSN1_HUMAN
θ value	θ > 10 (rank : 114)	NC score	0.112334 (rank : 96)
Query Neighborhood Hits	77	Target Neighborhood Hits	1757	Shared Neighborhood Hits	28
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	θ > 10 (rank : 115)	NC score	0.111552 (rank : 97)
Query Neighborhood Hits	77	Target Neighborhood Hits	1669	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
θ value	θ > 10 (rank : 116)	NC score	0.114932 (rank : 92)
Query Neighborhood Hits	77	Target Neighborhood Hits	1173	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	θ > 10 (rank : 117)	NC score	0.113078 (rank : 94)
Query Neighborhood Hits	77	Target Neighborhood Hits	1371	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

LBC_HUMAN
θ value	θ > 10 (rank : 118)	NC score	0.133918 (rank : 83)
Query Neighborhood Hits	77	Target Neighborhood Hits	90	Shared Neighborhood Hits	15
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

MCF2L_MOUSE
θ value	θ > 10 (rank : 119)	NC score	0.149545 (rank : 77)
Query Neighborhood Hits	77	Target Neighborhood Hits	255	Shared Neighborhood Hits	21
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.152064 (rank : 75)
Query Neighborhood Hits	77	Target Neighborhood Hits	166	Shared Neighborhood Hits	20
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

NGEF_HUMAN
θ value	θ > 10 (rank : 121)	NC score	0.177070 (rank : 63)
Query Neighborhood Hits	77	Target Neighborhood Hits	166	Shared Neighborhood Hits	18
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 122)	NC score	0.173696 (rank : 65)
Query Neighborhood Hits	77	Target Neighborhood Hits	228	Shared Neighborhood Hits	17
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PKHA4_HUMAN
θ value	θ > 10 (rank : 123)	NC score	0.065140 (rank : 126)
Query Neighborhood Hits	77	Target Neighborhood Hits	283	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_MOUSE
θ value	θ > 10 (rank : 124)	NC score	0.065540 (rank : 125)
Query Neighborhood Hits	77	Target Neighborhood Hits	202	Shared Neighborhood Hits	16
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA5_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.087479 (rank : 114)
Query Neighborhood Hits	77	Target Neighborhood Hits	455	Shared Neighborhood Hits	26
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA6_HUMAN
θ value	θ > 10 (rank : 126)	NC score	0.117281 (rank : 91)
Query Neighborhood Hits	77	Target Neighborhood Hits	556	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	θ > 10 (rank : 127)	NC score	0.113948 (rank : 93)
Query Neighborhood Hits	77	Target Neighborhood Hits	591	Shared Neighborhood Hits	27
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHG1_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.195510 (rank : 59)
Query Neighborhood Hits	77	Target Neighborhood Hits	174	Shared Neighborhood Hits	18
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PKHG4_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.150954 (rank : 76)
Query Neighborhood Hits	77	Target Neighborhood Hits	200	Shared Neighborhood Hits	18
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

RFFL_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.079215 (rank : 120)
Query Neighborhood Hits	77	Target Neighborhood Hits	175	Shared Neighborhood Hits	25
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

RFFL_MOUSE
θ value	θ > 10 (rank : 131)	NC score	0.093859 (rank : 110)
Query Neighborhood Hits	77	Target Neighborhood Hits	145	Shared Neighborhood Hits	29
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RGNEF_MOUSE
θ value	θ > 10 (rank : 132)	NC score	0.084727 (rank : 117)
Query Neighborhood Hits	77	Target Neighborhood Hits	641	Shared Neighborhood Hits	22
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RNF34_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.087263 (rank : 115)
Query Neighborhood Hits	77	Target Neighborhood Hits	153	Shared Neighborhood Hits	27
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

RNF34_MOUSE
θ value	θ > 10 (rank : 134)	NC score	0.096860 (rank : 107)
Query Neighborhood Hits	77	Target Neighborhood Hits	160	Shared Neighborhood Hits	29
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

RUFY3_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.142031 (rank : 82)
Query Neighborhood Hits	77	Target Neighborhood Hits	594	Shared Neighborhood Hits	10
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RUFY3_MOUSE
θ value	θ > 10 (rank : 136)	NC score	0.143250 (rank : 81)
Query Neighborhood Hits	77	Target Neighborhood Hits	579	Shared Neighborhood Hits	10
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

SOS1_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.077649 (rank : 121)
Query Neighborhood Hits	77	Target Neighborhood Hits	274	Shared Neighborhood Hits	14
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.069791 (rank : 124)
Query Neighborhood Hits	77	Target Neighborhood Hits	281	Shared Neighborhood Hits	15
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS2_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.087806 (rank : 113)
Query Neighborhood Hits	77	Target Neighborhood Hits	193	Shared Neighborhood Hits	15
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

TIAM1_HUMAN
θ value	θ > 10 (rank : 140)	NC score	0.125934 (rank : 85)
Query Neighborhood Hits	77	Target Neighborhood Hits	225	Shared Neighborhood Hits	17
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 141)	NC score	0.122480 (rank : 88)
Query Neighborhood Hits	77	Target Neighborhood Hits	205	Shared Neighborhood Hits	18
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TRIO_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.064097 (rank : 127)
Query Neighborhood Hits	77	Target Neighborhood Hits	1580	Shared Neighborhood Hits	27
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

TSC1_HUMAN
θ value	θ > 10 (rank : 143)	NC score	0.050042 (rank : 138)
Query Neighborhood Hits	77	Target Neighborhood Hits	765	Shared Neighborhood Hits	12
SwissProt Accessions	Q92574	Gene names	TSC1, KIAA0243, TSC
Domain Architecture
Description	Hamartin (Tuberous sclerosis 1 protein).

VAV2_MOUSE
θ value	θ > 10 (rank : 144)	NC score	0.097416 (rank : 105)
Query Neighborhood Hits	77	Target Neighborhood Hits	456	Shared Neighborhood Hits	21
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.095807 (rank : 108)
Query Neighborhood Hits	77	Target Neighborhood Hits	398	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 146)	NC score	0.095297 (rank : 109)
Query Neighborhood Hits	77	Target Neighborhood Hits	404	Shared Neighborhood Hits	15
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.101502 (rank : 103)
Query Neighborhood Hits	77	Target Neighborhood Hits	452	Shared Neighborhood Hits	17
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 148)	NC score	0.100322 (rank : 104)
Query Neighborhood Hits	77	Target Neighborhood Hits	430	Shared Neighborhood Hits	16
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ZFY27_HUMAN
θ value	θ > 10 (rank : 149)	NC score	0.255736 (rank : 51)
Query Neighborhood Hits	77	Target Neighborhood Hits	64	Shared Neighborhood Hits	39
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

ZFY27_MOUSE
θ value	θ > 10 (rank : 150)	NC score	0.257597 (rank : 50)
Query Neighborhood Hits	77	Target Neighborhood Hits	53	Shared Neighborhood Hits	39
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

Hits sorted by NC score

PKHF2_MOUSE
NC score	0.999962 (rank : 1)	θ value	5.41814e-138 (rank : 1)
Query Neighborhood Hits	77	Target Neighborhood Hits	77	Shared Neighborhood Hits	77
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHF2_HUMAN
NC score	0.999710 (rank : 2)	θ value	1.12976e-135 (rank : 2)
Query Neighborhood Hits	77	Target Neighborhood Hits	75	Shared Neighborhood Hits	74
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF1_HUMAN
NC score	0.982650 (rank : 3)	θ value	5.33382e-77 (rank : 3)
Query Neighborhood Hits	77	Target Neighborhood Hits	76	Shared Neighborhood Hits	64
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
NC score	0.980578 (rank : 4)	θ value	2.24094e-75 (rank : 4)
Query Neighborhood Hits	77	Target Neighborhood Hits	80	Shared Neighborhood Hits	65
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

FGD6_HUMAN
NC score	0.733211 (rank : 5)	θ value	4.57862e-28 (rank : 5)
Query Neighborhood Hits	77	Target Neighborhood Hits	237	Shared Neighborhood Hits	64
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

ZFY28_HUMAN
NC score	0.728674 (rank : 6)	θ value	2.52405e-10 (rank : 24)
Query Neighborhood Hits	77	Target Neighborhood Hits	152	Shared Neighborhood Hits	48
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

FGD6_MOUSE
NC score	0.717377 (rank : 7)	θ value	1.37858e-24 (rank : 6)
Query Neighborhood Hits	77	Target Neighborhood Hits	282	Shared Neighborhood Hits	63
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD5_MOUSE
NC score	0.715581 (rank : 8)	θ value	1.68911e-14 (rank : 13)
Query Neighborhood Hits	77	Target Neighborhood Hits	170	Shared Neighborhood Hits	59
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

ZFY21_MOUSE
NC score	0.708507 (rank : 9)	θ value	1.99992e-07 (rank : 38)
Query Neighborhood Hits	77	Target Neighborhood Hits	72	Shared Neighborhood Hits	48
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

FGD5_HUMAN
NC score	0.705731 (rank : 10)	θ value	1.86753e-13 (rank : 14)
Query Neighborhood Hits	77	Target Neighborhood Hits	235	Shared Neighborhood Hits	57
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

ZFY21_HUMAN
NC score	0.703845 (rank : 11)	θ value	9.92553e-07 (rank : 43)
Query Neighborhood Hits	77	Target Neighborhood Hits	72	Shared Neighborhood Hits	48
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFYV9_HUMAN
NC score	0.685663 (rank : 12)	θ value	4.59992e-12 (rank : 19)
Query Neighborhood Hits	77	Target Neighborhood Hits	134	Shared Neighborhood Hits	49
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

ZFY16_MOUSE
NC score	0.669972 (rank : 13)	θ value	1.33837e-11 (rank : 23)
Query Neighborhood Hits	77	Target Neighborhood Hits	108	Shared Neighborhood Hits	48
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY16_HUMAN
NC score	0.659670 (rank : 14)	θ value	7.84624e-12 (rank : 20)
Query Neighborhood Hits	77	Target Neighborhood Hits	125	Shared Neighborhood Hits	48
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

FGD2_MOUSE
NC score	0.658198 (rank : 15)	θ value	1.80466e-16 (rank : 11)
Query Neighborhood Hits	77	Target Neighborhood Hits	163	Shared Neighborhood Hits	64
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD2_HUMAN
NC score	0.653246 (rank : 16)	θ value	3.63628e-17 (rank : 8)
Query Neighborhood Hits	77	Target Neighborhood Hits	151	Shared Neighborhood Hits	63
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD4_HUMAN
NC score	0.634891 (rank : 17)	θ value	5.60996e-18 (rank : 7)
Query Neighborhood Hits	77	Target Neighborhood Hits	219	Shared Neighborhood Hits	65
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
NC score	0.630118 (rank : 18)	θ value	5.25075e-16 (rank : 12)
Query Neighborhood Hits	77	Target Neighborhood Hits	227	Shared Neighborhood Hits	67
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD1_HUMAN
NC score	0.623435 (rank : 19)	θ value	1.80466e-16 (rank : 10)
Query Neighborhood Hits	77	Target Neighborhood Hits	367	Shared Neighborhood Hits	61
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
NC score	0.619946 (rank : 20)	θ value	1.38178e-16 (rank : 9)
Query Neighborhood Hits	77	Target Neighborhood Hits	387	Shared Neighborhood Hits	60
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ZFYV1_HUMAN
NC score	0.581649 (rank : 21)	θ value	1.53129e-07 (rank : 37)
Query Neighborhood Hits	77	Target Neighborhood Hits	166	Shared Neighborhood Hits	48
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
NC score	0.577852 (rank : 22)	θ value	1.99992e-07 (rank : 39)
Query Neighborhood Hits	77	Target Neighborhood Hits	153	Shared Neighborhood Hits	48
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

FGD3_HUMAN
NC score	0.574849 (rank : 23)	θ value	1.38499e-08 (rank : 33)
Query Neighborhood Hits	77	Target Neighborhood Hits	249	Shared Neighborhood Hits	57
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

HGS_HUMAN
NC score	0.545147 (rank : 24)	θ value	1.38499e-08 (rank : 34)
Query Neighborhood Hits	77	Target Neighborhood Hits	517	Shared Neighborhood Hits	49
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
NC score	0.543114 (rank : 25)	θ value	4.76016e-09 (rank : 27)
Query Neighborhood Hits	77	Target Neighborhood Hits	589	Shared Neighborhood Hits	49
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

FGD3_MOUSE
NC score	0.532722 (rank : 26)	θ value	1.69304e-06 (rank : 46)
Query Neighborhood Hits	77	Target Neighborhood Hits	257	Shared Neighborhood Hits	62
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FYV1_HUMAN
NC score	0.491018 (rank : 27)	θ value	1.17247e-07 (rank : 35)
Query Neighborhood Hits	77	Target Neighborhood Hits	217	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

RBNS5_HUMAN
NC score	0.491011 (rank : 28)	θ value	9.29e-05 (rank : 49)
Query Neighborhood Hits	77	Target Neighborhood Hits	242	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

FYV1_MOUSE
NC score	0.490406 (rank : 29)	θ value	1.17247e-07 (rank : 36)
Query Neighborhood Hits	77	Target Neighborhood Hits	191	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

RBNS5_MOUSE
NC score	0.484775 (rank : 30)	θ value	0.00020696 (rank : 50)
Query Neighborhood Hits	77	Target Neighborhood Hits	266	Shared Neighborhood Hits	49
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

WDFY1_HUMAN
NC score	0.439190 (rank : 31)	θ value	6.21693e-09 (rank : 28)
Query Neighborhood Hits	77	Target Neighborhood Hits	305	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

ZFY19_HUMAN
NC score	0.431930 (rank : 32)	θ value	0.0252991 (rank : 53)
Query Neighborhood Hits	77	Target Neighborhood Hits	206	Shared Neighborhood Hits	46
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ZFY19_MOUSE
NC score	0.425760 (rank : 33)	θ value	0.0431538 (rank : 55)
Query Neighborhood Hits	77	Target Neighborhood Hits	143	Shared Neighborhood Hits	48
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

RUFY2_MOUSE
NC score	0.419807 (rank : 34)	θ value	4.59992e-12 (rank : 18)
Query Neighborhood Hits	77	Target Neighborhood Hits	820	Shared Neighborhood Hits	50
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

RUFY1_MOUSE
NC score	0.419499 (rank : 35)	θ value	3.52202e-12 (rank : 17)
Query Neighborhood Hits	77	Target Neighborhood Hits	765	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

WDFY2_MOUSE
NC score	0.418158 (rank : 36)	θ value	5.81887e-07 (rank : 40)
Query Neighborhood Hits	77	Target Neighborhood Hits	337	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

WDFY2_HUMAN
NC score	0.414357 (rank : 37)	θ value	9.92553e-07 (rank : 42)
Query Neighborhood Hits	77	Target Neighborhood Hits	332	Shared Neighborhood Hits	48
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

RUFY1_HUMAN
NC score	0.413831 (rank : 38)	θ value	2.0648e-12 (rank : 16)
Query Neighborhood Hits	77	Target Neighborhood Hits	848	Shared Neighborhood Hits	51
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

MTMR3_HUMAN
NC score	0.402971 (rank : 39)	θ value	2.13673e-09 (rank : 26)
Query Neighborhood Hits	77	Target Neighborhood Hits	163	Shared Neighborhood Hits	48
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

WDFY3_MOUSE
NC score	0.388759 (rank : 40)	θ value	1.29631e-06 (rank : 45)
Query Neighborhood Hits	77	Target Neighborhood Hits	332	Shared Neighborhood Hits	48
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

WDFY3_HUMAN
NC score	0.387596 (rank : 41)	θ value	1.29631e-06 (rank : 44)
Query Neighborhood Hits	77	Target Neighborhood Hits	348	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

RUFY2_HUMAN
NC score	0.333812 (rank : 42)	θ value	1.2105e-12 (rank : 15)
Query Neighborhood Hits	77	Target Neighborhood Hits	1208	Shared Neighborhood Hits	50
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

FARP2_HUMAN
NC score	0.323875 (rank : 43)	θ value	8.11959e-09 (rank : 29)
Query Neighborhood Hits	77	Target Neighborhood Hits	240	Shared Neighborhood Hits	30
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
NC score	0.322777 (rank : 44)	θ value	8.11959e-09 (rank : 30)
Query Neighborhood Hits	77	Target Neighborhood Hits	209	Shared Neighborhood Hits	31
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP1_HUMAN
NC score	0.318665 (rank : 45)	θ value	1.25267e-09 (rank : 25)
Query Neighborhood Hits	77	Target Neighborhood Hits	241	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

ANFY1_MOUSE
NC score	0.277581 (rank : 46)	θ value	1.06045e-08 (rank : 31)
Query Neighborhood Hits	77	Target Neighborhood Hits	480	Shared Neighborhood Hits	48
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_HUMAN
NC score	0.277565 (rank : 47)	θ value	1.38499e-08 (rank : 32)
Query Neighborhood Hits	77	Target Neighborhood Hits	480	Shared Neighborhood Hits	48
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

PREX1_HUMAN
NC score	0.268890 (rank : 48)	θ value	0.00175202 (rank : 52)
Query Neighborhood Hits	77	Target Neighborhood Hits	177	Shared Neighborhood Hits	25
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

FYCO1_HUMAN
NC score	0.265873 (rank : 49)	θ value	7.59969e-07 (rank : 41)
Query Neighborhood Hits	77	Target Neighborhood Hits	1149	Shared Neighborhood Hits	51
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

ZFY27_MOUSE
NC score	0.257597 (rank : 50)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	77	Target Neighborhood Hits	53	Shared Neighborhood Hits	39
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

ZFY27_HUMAN
NC score	0.255736 (rank : 51)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	77	Target Neighborhood Hits	64	Shared Neighborhood Hits	39
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

EEA1_MOUSE
NC score	0.251571 (rank : 52)	θ value	1.33837e-11 (rank : 22)
Query Neighborhood Hits	77	Target Neighborhood Hits	1637	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

FYCO1_MOUSE
NC score	0.238747 (rank : 53)	θ value	0.000461057 (rank : 51)
Query Neighborhood Hits	77	Target Neighborhood Hits	1059	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

EEA1_HUMAN
NC score	0.233109 (rank : 54)	θ value	1.33837e-11 (rank : 21)
Query Neighborhood Hits	77	Target Neighborhood Hits	1796	Shared Neighborhood Hits	51
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

ECT2_MOUSE
NC score	0.219127 (rank : 55)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	77	Target Neighborhood Hits	98	Shared Neighborhood Hits	19
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_HUMAN
NC score	0.213750 (rank : 56)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	77	Target Neighborhood Hits	98	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ALS2_MOUSE
NC score	0.208899 (rank : 57)	θ value	1.09739e-05 (rank : 47)
Query Neighborhood Hits	77	Target Neighborhood Hits	111	Shared Neighborhood Hits	20
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

ALS2_HUMAN
NC score	0.196619 (rank : 58)	θ value	2.44474e-05 (rank : 48)
Query Neighborhood Hits	77	Target Neighborhood Hits	121	Shared Neighborhood Hits	20
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

PKHG1_HUMAN
NC score	0.195510 (rank : 59)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	77	Target Neighborhood Hits	174	Shared Neighborhood Hits	18
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHG5_HUMAN
NC score	0.186095 (rank : 60)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	77	Target Neighborhood Hits	172	Shared Neighborhood Hits	18
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHGA_HUMAN
NC score	0.177750 (rank : 61)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	77	Target Neighborhood Hits	187	Shared Neighborhood Hits	20
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
NC score	0.177723 (rank : 62)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	77	Target Neighborhood Hits	125	Shared Neighborhood Hits	20
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

NGEF_HUMAN
NC score	0.177070 (rank : 63)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	77	Target Neighborhood Hits	166	Shared Neighborhood Hits	18
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHGG_HUMAN
NC score	0.173891 (rank : 64)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	77	Target Neighborhood Hits	129	Shared Neighborhood Hits	18
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

NGEF_MOUSE
NC score	0.173696 (rank : 65)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	77	Target Neighborhood Hits	228	Shared Neighborhood Hits	17
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHG4_HUMAN
NC score	0.169262 (rank : 66)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	77	Target Neighborhood Hits	242	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
NC score	0.169078 (rank : 67)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	77	Target Neighborhood Hits	185	Shared Neighborhood Hits	16
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

HAPIP_HUMAN
NC score	0.166631 (rank : 68)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	77	Target Neighborhood Hits	350	Shared Neighborhood Hits	26
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ARHG2_MOUSE
NC score	0.165396 (rank : 69)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	77	Target Neighborhood Hits	120	Shared Neighborhood Hits	18
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHGG_MOUSE
NC score	0.163822 (rank : 70)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	77	Target Neighborhood Hits	152	Shared Neighborhood Hits	18
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGF_HUMAN
NC score	0.163602 (rank : 71)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	77	Target Neighborhood Hits	214	Shared Neighborhood Hits	18
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

GNRP_MOUSE
NC score	0.158162 (rank : 72)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	77	Target Neighborhood Hits	191	Shared Neighborhood Hits	25
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ARHG9_HUMAN
NC score	0.154629 (rank : 73)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	77	Target Neighborhood Hits	235	Shared Neighborhood Hits	17
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.152877 (rank : 74)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	77	Target Neighborhood Hits	234	Shared Neighborhood Hits	17
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

MCF2_HUMAN
NC score	0.152064 (rank : 75)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	77	Target Neighborhood Hits	166	Shared Neighborhood Hits	20
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

PKHG4_HUMAN
NC score	0.150954 (rank : 76)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	77	Target Neighborhood Hits	200	Shared Neighborhood Hits	18
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

MCF2L_MOUSE
NC score	0.149545 (rank : 77)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	77	Target Neighborhood Hits	255	Shared Neighborhood Hits	21
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

GNRP_HUMAN
NC score	0.148639 (rank : 78)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	77	Target Neighborhood Hits	239	Shared Neighborhood Hits	25
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

ABR_HUMAN
NC score	0.144968 (rank : 79)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	77	Target Neighborhood Hits	166	Shared Neighborhood Hits	19
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

BCR_HUMAN
NC score	0.144674 (rank : 80)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	77	Target Neighborhood Hits	204	Shared Neighborhood Hits	19
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

RUFY3_MOUSE
NC score	0.143250 (rank : 81)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	77	Target Neighborhood Hits	579	Shared Neighborhood Hits	10
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RUFY3_HUMAN
NC score	0.142031 (rank : 82)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	77	Target Neighborhood Hits	594	Shared Neighborhood Hits	10
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

LBC_HUMAN
NC score	0.133918 (rank : 83)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	77	Target Neighborhood Hits	90	Shared Neighborhood Hits	15
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHG7_HUMAN
NC score	0.128046 (rank : 84)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	77	Target Neighborhood Hits	347	Shared Neighborhood Hits	20
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

TIAM1_HUMAN
NC score	0.125934 (rank : 85)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	77	Target Neighborhood Hits	225	Shared Neighborhood Hits	17
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG1_HUMAN
NC score	0.124684 (rank : 86)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	77	Target Neighborhood Hits	176	Shared Neighborhood Hits	15
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
NC score	0.123464 (rank : 87)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	77	Target Neighborhood Hits	266	Shared Neighborhood Hits	15
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

TIAM1_MOUSE
NC score	0.122480 (rank : 88)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	77	Target Neighborhood Hits	205	Shared Neighborhood Hits	18
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG2_HUMAN
NC score	0.119797 (rank : 89)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	77	Target Neighborhood Hits	142	Shared Neighborhood Hits	15
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHGB_HUMAN
NC score	0.119594 (rank : 90)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	77	Target Neighborhood Hits	375	Shared Neighborhood Hits	18
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

PKHA6_HUMAN
NC score	0.117281 (rank : 91)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	77	Target Neighborhood Hits	556	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

ITSN2_HUMAN
NC score	0.114932 (rank : 92)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	77	Target Neighborhood Hits	1173	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

PKHA6_MOUSE
NC score	0.113948 (rank : 93)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	77	Target Neighborhood Hits	591	Shared Neighborhood Hits	27
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

ITSN2_MOUSE
NC score	0.113078 (rank : 94)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	77	Target Neighborhood Hits	1371	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ARHGC_HUMAN
NC score	0.112615 (rank : 95)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	77	Target Neighborhood Hits	351	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ITSN1_HUMAN
NC score	0.112334 (rank : 96)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	77	Target Neighborhood Hits	1757	Shared Neighborhood Hits	28
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.111552 (rank : 97)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	77	Target Neighborhood Hits	1669	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ARHGC_MOUSE
NC score	0.111481 (rank : 98)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	77	Target Neighborhood Hits	344	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHG8_HUMAN
NC score	0.110820 (rank : 99)	θ value	8.99809 (rank : 75)
Query Neighborhood Hits	77	Target Neighborhood Hits	85	Shared Neighborhood Hits	18
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

SWP70_HUMAN
NC score	0.108263 (rank : 100)	θ value	0.0431538 (rank : 54)
Query Neighborhood Hits	77	Target Neighborhood Hits	973	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

ARHG7_MOUSE
NC score	0.107759 (rank : 101)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	77	Target Neighborhood Hits	396	Shared Neighborhood Hits	18
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

SWP70_MOUSE
NC score	0.102379 (rank : 102)	θ value	0.0736092 (rank : 58)
Query Neighborhood Hits	77	Target Neighborhood Hits	1097	Shared Neighborhood Hits	33
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

VAV_HUMAN
NC score	0.101502 (rank : 103)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	77	Target Neighborhood Hits	452	Shared Neighborhood Hits	17
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
NC score	0.100322 (rank : 104)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	77	Target Neighborhood Hits	430	Shared Neighborhood Hits	16
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV2_MOUSE
NC score	0.097416 (rank : 105)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	77	Target Neighborhood Hits	456	Shared Neighborhood Hits	21
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV2_HUMAN
NC score	0.096959 (rank : 106)	θ value	1.06291 (rank : 65)
Query Neighborhood Hits	77	Target Neighborhood Hits	453	Shared Neighborhood Hits	20
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

RNF34_MOUSE
NC score	0.096860 (rank : 107)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	77	Target Neighborhood Hits	160	Shared Neighborhood Hits	29
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

VAV3_HUMAN
NC score	0.095807 (rank : 108)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	77	Target Neighborhood Hits	398	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
NC score	0.095297 (rank : 109)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	77	Target Neighborhood Hits	404	Shared Neighborhood Hits	15
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

RFFL_MOUSE
NC score	0.093859 (rank : 110)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	77	Target Neighborhood Hits	145	Shared Neighborhood Hits	29
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

ARHG3_MOUSE
NC score	0.092767 (rank : 111)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	77	Target Neighborhood Hits	85	Shared Neighborhood Hits	12
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG3_HUMAN
NC score	0.091386 (rank : 112)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	77	Target Neighborhood Hits	82	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

SOS2_HUMAN
NC score	0.087806 (rank : 113)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	77	Target Neighborhood Hits	193	Shared Neighborhood Hits	15
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

PKHA5_HUMAN
NC score	0.087479 (rank : 114)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	77	Target Neighborhood Hits	455	Shared Neighborhood Hits	26
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

RNF34_HUMAN
NC score	0.087263 (rank : 115)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	77	Target Neighborhood Hits	153	Shared Neighborhood Hits	27
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

DNMBP_MOUSE
NC score	0.086243 (rank : 116)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	77	Target Neighborhood Hits	435	Shared Neighborhood Hits	16
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

RGNEF_MOUSE
NC score	0.084727 (rank : 117)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	77	Target Neighborhood Hits	641	Shared Neighborhood Hits	22
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ARHG6_HUMAN
NC score	0.083319 (rank : 118)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	77	Target Neighborhood Hits	376	Shared Neighborhood Hits	13
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

DNMBP_HUMAN
NC score	0.081818 (rank : 119)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	77	Target Neighborhood Hits	413	Shared Neighborhood Hits	19
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

RFFL_HUMAN
NC score	0.079215 (rank : 120)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	77	Target Neighborhood Hits	175	Shared Neighborhood Hits	25
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

SOS1_HUMAN
NC score	0.077649 (rank : 121)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	77	Target Neighborhood Hits	274	Shared Neighborhood Hits	14
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

ARHG6_MOUSE
NC score	0.074258 (rank : 122)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	77	Target Neighborhood Hits	394	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

CJ064_HUMAN
NC score	0.072466 (rank : 123)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	77	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZS81, Q8N4A3	Gene names	C10orf64
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf64.

SOS1_MOUSE
NC score	0.069791 (rank : 124)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	77	Target Neighborhood Hits	281	Shared Neighborhood Hits	15
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

PKHA4_MOUSE
NC score	0.065540 (rank : 125)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	77	Target Neighborhood Hits	202	Shared Neighborhood Hits	16
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_HUMAN
NC score	0.065140 (rank : 126)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	77	Target Neighborhood Hits	283	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

TRIO_HUMAN
NC score	0.064097 (rank : 127)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	77	Target Neighborhood Hits	1580	Shared Neighborhood Hits	27
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

CYH4_MOUSE
NC score	0.063626 (rank : 128)	θ value	0.163984 (rank : 59)
Query Neighborhood Hits	77	Target Neighborhood Hits	134	Shared Neighborhood Hits	21
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

DUET_HUMAN
NC score	0.062801 (rank : 129)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	77	Target Neighborhood Hits	1220	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

ARHG8_MOUSE
NC score	0.061657 (rank : 130)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	77	Target Neighborhood Hits	79	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

S4A7_MOUSE
NC score	0.060273 (rank : 131)	θ value	0.0736092 (rank : 57)
Query Neighborhood Hits	77	Target Neighborhood Hits	30	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BTY2, Q3U5H7	Gene names	Slc4a7, Nbc3
Domain Architecture	No domain graphic available
Description	Sodium bicarbonate cotransporter 3 (Solute carrier family 4 member 7).

S4A7_HUMAN
NC score	0.057925 (rank : 132)	θ value	0.0736092 (rank : 56)
Query Neighborhood Hits	77	Target Neighborhood Hits	55	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y6M7, O60350, Q6AHZ9, Q9HC88, Q9UIB9	Gene names	SLC4A7, BT, NBC2, NBC2B, NBC3, SBC2, SLC4A6
Domain Architecture	No domain graphic available
Description	Sodium bicarbonate cotransporter 3 (Sodium bicarbonate cotransporter 2) (Sodium bicarbonate cotransporter 2b) (Bicarbonate transporter) (Solute carrier family 4 member 7).

CYH3_MOUSE
NC score	0.057731 (rank : 133)	θ value	8.99809 (rank : 76)
Query Neighborhood Hits	77	Target Neighborhood Hits	148	Shared Neighborhood Hits	21
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

CYH4_HUMAN
NC score	0.055470 (rank : 134)	θ value	1.06291 (rank : 63)
Query Neighborhood Hits	77	Target Neighborhood Hits	135	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

CNKR1_HUMAN
NC score	0.055269 (rank : 135)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	77	Target Neighborhood Hits	154	Shared Neighborhood Hits	16
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

S4A10_MOUSE
NC score	0.052092 (rank : 136)	θ value	0.279714 (rank : 61)
Query Neighborhood Hits	77	Target Neighborhood Hits	23	Shared Neighborhood Hits	8
SwissProt Accessions	Q5DTL9, Q8CFS3, Q9EST0	Gene names	Slc4a10, Kiaa4136, Ncbe
Domain Architecture	No domain graphic available
Description	Sodium-driven chloride bicarbonate exchanger (Solute carrier family 4 member 10).

S4A10_HUMAN
NC score	0.051842 (rank : 137)	θ value	0.279714 (rank : 60)
Query Neighborhood Hits	77	Target Neighborhood Hits	33	Shared Neighborhood Hits	8
SwissProt Accessions	Q6U841, Q4ZFX6, Q8TCP2, Q9HCQ6	Gene names	SLC4A10, NCBE
Domain Architecture	No domain graphic available
Description	Sodium-driven chloride bicarbonate exchanger (Solute carrier family 4 member 10).

TSC1_HUMAN
NC score	0.050042 (rank : 138)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	77	Target Neighborhood Hits	765	Shared Neighborhood Hits	12
SwissProt Accessions	Q92574	Gene names	TSC1, KIAA0243, TSC
Domain Architecture
Description	Hamartin (Tuberous sclerosis 1 protein).

MYRIP_MOUSE
NC score	0.049961 (rank : 139)	θ value	6.88961 (rank : 73)
Query Neighborhood Hits	77	Target Neighborhood Hits	207	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

CYH2_MOUSE
NC score	0.041778 (rank : 140)	θ value	6.88961 (rank : 72)
Query Neighborhood Hits	77	Target Neighborhood Hits	171	Shared Neighborhood Hits	21
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH2_HUMAN
NC score	0.041754 (rank : 141)	θ value	6.88961 (rank : 71)
Query Neighborhood Hits	77	Target Neighborhood Hits	175	Shared Neighborhood Hits	21
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

EXOC8_MOUSE
NC score	0.038478 (rank : 142)	θ value	3.0926 (rank : 68)
Query Neighborhood Hits	77	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	Q6PGF7	Gene names	Exoc8
Domain Architecture	No domain graphic available
Description	Exocyst complex component 8 (Exocyst complex 84 kDa subunit).

TRI32_HUMAN
NC score	0.033675 (rank : 143)	θ value	0.813845 (rank : 62)
Query Neighborhood Hits	77	Target Neighborhood Hits	264	Shared Neighborhood Hits	9
SwissProt Accessions	Q13049, Q9NQP8	Gene names	TRIM32, HT2A
Domain Architecture
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-) (Zinc finger protein HT2A) (72 kDa Tat-interacting protein).

CEND1_HUMAN
NC score	0.033384 (rank : 144)	θ value	2.36792 (rank : 66)
Query Neighborhood Hits	77	Target Neighborhood Hits	284	Shared Neighborhood Hits	23
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

TRI32_MOUSE
NC score	0.031477 (rank : 145)	θ value	1.06291 (rank : 64)
Query Neighborhood Hits	77	Target Neighborhood Hits	271	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CH72, Q8K055	Gene names	Trim32
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-).

CEND1_MOUSE
NC score	0.030277 (rank : 146)	θ value	4.03905 (rank : 69)
Query Neighborhood Hits	77	Target Neighborhood Hits	260	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

ZDH21_MOUSE
NC score	0.024399 (rank : 147)	θ value	2.36792 (rank : 67)
Query Neighborhood Hits	77	Target Neighborhood Hits	53	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D270, Q6EMK1, Q80XQ3	Gene names	Zdhhc21, Gramp3
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC21 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 21) (DHHC-21) (GABA-A receptor-associated membrane protein 3).

SYTL3_MOUSE
NC score	0.018004 (rank : 148)	θ value	6.88961 (rank : 74)
Query Neighborhood Hits	77	Target Neighborhood Hits	110	Shared Neighborhood Hits	9
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

SMYD1_MOUSE
NC score	0.013464 (rank : 149)	θ value	5.27518 (rank : 70)
Query Neighborhood Hits	77	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	P97443, P97442, P97444	Gene names	Smyd1, Bop
Domain Architecture
Description	SET and MYND domain-containing protein 1 (Zinc-finger protein BOP) (m- BOP) (CD8b-opposite).

ZDH21_HUMAN
NC score	0.012208 (rank : 150)	θ value	8.99809 (rank : 77)
Query Neighborhood Hits	77	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IVQ6, Q5VWG1	Gene names	ZDHHC21
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC21 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 21) (DHHC-21).