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Network neighborhood for query Sequence : NGEF_MOUSE

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NGEF_MOUSE
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NGEF_HUMAN
θ value	0 (rank : 1)	NC score	0.982959 (rank : 2)
Query Neighborhood Hits	228	Target Neighborhood Hits	166	Shared Neighborhood Hits	139
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	228	Target Neighborhood Hits	228	Shared Neighborhood Hits	228
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHG5_HUMAN
θ value	4.05562e-101 (rank : 3)	NC score	0.920911 (rank : 3)
Query Neighborhood Hits	228	Target Neighborhood Hits	172	Shared Neighborhood Hits	115
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHGG_MOUSE
θ value	1.03614e-88 (rank : 4)	NC score	0.914799 (rank : 5)
Query Neighborhood Hits	228	Target Neighborhood Hits	152	Shared Neighborhood Hits	108
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_HUMAN
θ value	3.93732e-88 (rank : 5)	NC score	0.915839 (rank : 4)
Query Neighborhood Hits	228	Target Neighborhood Hits	129	Shared Neighborhood Hits	97
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGF_HUMAN
θ value	5.69867e-79 (rank : 6)	NC score	0.864390 (rank : 6)
Query Neighborhood Hits	228	Target Neighborhood Hits	214	Shared Neighborhood Hits	73
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ITSN1_HUMAN
θ value	3.07116e-24 (rank : 7)	NC score	0.498074 (rank : 50)
Query Neighborhood Hits	228	Target Neighborhood Hits	1757	Shared Neighborhood Hits	176
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	6.84181e-24 (rank : 8)	NC score	0.498777 (rank : 49)
Query Neighborhood Hits	228	Target Neighborhood Hits	1669	Shared Neighborhood Hits	169
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
θ value	5.79196e-23 (rank : 9)	NC score	0.534647 (rank : 39)
Query Neighborhood Hits	228	Target Neighborhood Hits	1173	Shared Neighborhood Hits	154
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	1.86321e-21 (rank : 10)	NC score	0.506476 (rank : 45)
Query Neighborhood Hits	228	Target Neighborhood Hits	1371	Shared Neighborhood Hits	158
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

FGD4_MOUSE
θ value	1.02238e-19 (rank : 11)	NC score	0.643770 (rank : 11)
Query Neighborhood Hits	228	Target Neighborhood Hits	227	Shared Neighborhood Hits	70
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD4_HUMAN
θ value	2.27762e-19 (rank : 12)	NC score	0.644496 (rank : 10)
Query Neighborhood Hits	228	Target Neighborhood Hits	219	Shared Neighborhood Hits	71
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD1_MOUSE
θ value	5.07402e-19 (rank : 13)	NC score	0.622706 (rank : 21)
Query Neighborhood Hits	228	Target Neighborhood Hits	387	Shared Neighborhood Hits	75
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_HUMAN
θ value	1.13037e-18 (rank : 14)	NC score	0.623099 (rank : 20)
Query Neighborhood Hits	228	Target Neighborhood Hits	367	Shared Neighborhood Hits	76
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ARHGC_MOUSE
θ value	2.13179e-17 (rank : 15)	NC score	0.609724 (rank : 25)
Query Neighborhood Hits	228	Target Neighborhood Hits	344	Shared Neighborhood Hits	69
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_HUMAN
θ value	3.07829e-16 (rank : 16)	NC score	0.608032 (rank : 26)
Query Neighborhood Hits	228	Target Neighborhood Hits	351	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

FGD3_HUMAN
θ value	1.52774e-15 (rank : 17)	NC score	0.625222 (rank : 18)
Query Neighborhood Hits	228	Target Neighborhood Hits	249	Shared Neighborhood Hits	69
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	1.52774e-15 (rank : 18)	NC score	0.640051 (rank : 12)
Query Neighborhood Hits	228	Target Neighborhood Hits	257	Shared Neighborhood Hits	72
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD2_HUMAN
θ value	1.99529e-15 (rank : 19)	NC score	0.627051 (rank : 15)
Query Neighborhood Hits	228	Target Neighborhood Hits	151	Shared Neighborhood Hits	69
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	9.90251e-15 (rank : 20)	NC score	0.626306 (rank : 17)
Query Neighborhood Hits	228	Target Neighborhood Hits	163	Shared Neighborhood Hits	69
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

VAV2_MOUSE
θ value	9.90251e-15 (rank : 21)	NC score	0.527653 (rank : 41)
Query Neighborhood Hits	228	Target Neighborhood Hits	456	Shared Neighborhood Hits	128
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV2_HUMAN
θ value	1.29331e-14 (rank : 22)	NC score	0.531947 (rank : 40)
Query Neighborhood Hits	228	Target Neighborhood Hits	453	Shared Neighborhood Hits	128
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ARHGB_HUMAN
θ value	2.88119e-14 (rank : 23)	NC score	0.624691 (rank : 19)
Query Neighborhood Hits	228	Target Neighborhood Hits	375	Shared Neighborhood Hits	77
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

GNRP_MOUSE
θ value	1.86753e-13 (rank : 24)	NC score	0.510848 (rank : 44)
Query Neighborhood Hits	228	Target Neighborhood Hits	191	Shared Neighborhood Hits	63
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ARHG1_HUMAN
θ value	3.18553e-13 (rank : 25)	NC score	0.651711 (rank : 9)
Query Neighborhood Hits	228	Target Neighborhood Hits	176	Shared Neighborhood Hits	62
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	1.2105e-12 (rank : 26)	NC score	0.630160 (rank : 14)
Query Neighborhood Hits	228	Target Neighborhood Hits	266	Shared Neighborhood Hits	61
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

PREX1_HUMAN
θ value	1.58096e-12 (rank : 27)	NC score	0.626334 (rank : 16)
Query Neighborhood Hits	228	Target Neighborhood Hits	177	Shared Neighborhood Hits	71
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

GNRP_HUMAN
θ value	3.52202e-12 (rank : 28)	NC score	0.481068 (rank : 52)
Query Neighborhood Hits	228	Target Neighborhood Hits	239	Shared Neighborhood Hits	59
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

VAV_HUMAN
θ value	1.33837e-11 (rank : 29)	NC score	0.511026 (rank : 43)
Query Neighborhood Hits	228	Target Neighborhood Hits	452	Shared Neighborhood Hits	130
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ECT2_HUMAN
θ value	2.98157e-11 (rank : 30)	NC score	0.655921 (rank : 8)
Query Neighborhood Hits	228	Target Neighborhood Hits	98	Shared Neighborhood Hits	70
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	5.08577e-11 (rank : 31)	NC score	0.665085 (rank : 7)
Query Neighborhood Hits	228	Target Neighborhood Hits	98	Shared Neighborhood Hits	70
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

FGD6_MOUSE
θ value	5.08577e-11 (rank : 32)	NC score	0.541732 (rank : 36)
Query Neighborhood Hits	228	Target Neighborhood Hits	282	Shared Neighborhood Hits	71
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

VAV_MOUSE
θ value	5.08577e-11 (rank : 33)	NC score	0.521583 (rank : 42)
Query Neighborhood Hits	228	Target Neighborhood Hits	430	Shared Neighborhood Hits	133
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

FGD6_HUMAN
θ value	8.67504e-11 (rank : 34)	NC score	0.536746 (rank : 38)
Query Neighborhood Hits	228	Target Neighborhood Hits	237	Shared Neighborhood Hits	62
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

PKHG1_HUMAN
θ value	1.133e-10 (rank : 35)	NC score	0.598989 (rank : 29)
Query Neighborhood Hits	228	Target Neighborhood Hits	174	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

FARP2_MOUSE
θ value	1.47974e-10 (rank : 36)	NC score	0.424657 (rank : 60)
Query Neighborhood Hits	228	Target Neighborhood Hits	209	Shared Neighborhood Hits	70
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ARHG8_HUMAN
θ value	3.29651e-10 (rank : 37)	NC score	0.630984 (rank : 13)
Query Neighborhood Hits	228	Target Neighborhood Hits	85	Shared Neighborhood Hits	65
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	1.25267e-09 (rank : 38)	NC score	0.604171 (rank : 28)
Query Neighborhood Hits	228	Target Neighborhood Hits	79	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

RGNEF_MOUSE
θ value	2.79066e-09 (rank : 39)	NC score	0.505699 (rank : 46)
Query Neighborhood Hits	228	Target Neighborhood Hits	641	Shared Neighborhood Hits	80
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

FARP2_HUMAN
θ value	5.26297e-08 (rank : 40)	NC score	0.389207 (rank : 62)
Query Neighborhood Hits	228	Target Neighborhood Hits	240	Shared Neighborhood Hits	65
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ARHG2_HUMAN
θ value	8.97725e-08 (rank : 41)	NC score	0.574491 (rank : 33)
Query Neighborhood Hits	228	Target Neighborhood Hits	142	Shared Neighborhood Hits	61
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHGA_HUMAN
θ value	8.97725e-08 (rank : 42)	NC score	0.503545 (rank : 47)
Query Neighborhood Hits	228	Target Neighborhood Hits	187	Shared Neighborhood Hits	69
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHG3_MOUSE
θ value	1.53129e-07 (rank : 43)	NC score	0.620997 (rank : 23)
Query Neighborhood Hits	228	Target Neighborhood Hits	85	Shared Neighborhood Hits	63
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG3_HUMAN
θ value	2.61198e-07 (rank : 44)	NC score	0.622337 (rank : 22)
Query Neighborhood Hits	228	Target Neighborhood Hits	82	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

FARP1_HUMAN
θ value	2.61198e-07 (rank : 45)	NC score	0.368505 (rank : 67)
Query Neighborhood Hits	228	Target Neighborhood Hits	241	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

TIAM1_HUMAN
θ value	4.45536e-07 (rank : 46)	NC score	0.561117 (rank : 35)
Query Neighborhood Hits	228	Target Neighborhood Hits	225	Shared Neighborhood Hits	73
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG2_MOUSE
θ value	7.59969e-07 (rank : 47)	NC score	0.596046 (rank : 30)
Query Neighborhood Hits	228	Target Neighborhood Hits	120	Shared Neighborhood Hits	61
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG4_HUMAN
θ value	7.59969e-07 (rank : 48)	NC score	0.609800 (rank : 24)
Query Neighborhood Hits	228	Target Neighborhood Hits	242	Shared Neighborhood Hits	123
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

TIAM1_MOUSE
θ value	7.59969e-07 (rank : 49)	NC score	0.568599 (rank : 34)
Query Neighborhood Hits	228	Target Neighborhood Hits	205	Shared Neighborhood Hits	69
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG4_MOUSE
θ value	1.69304e-06 (rank : 50)	NC score	0.606820 (rank : 27)
Query Neighborhood Hits	228	Target Neighborhood Hits	185	Shared Neighborhood Hits	99
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG9_MOUSE
θ value	2.88788e-06 (rank : 51)	NC score	0.589961 (rank : 32)
Query Neighborhood Hits	228	Target Neighborhood Hits	234	Shared Neighborhood Hits	116
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG9_HUMAN
θ value	4.92598e-06 (rank : 52)	NC score	0.590019 (rank : 31)
Query Neighborhood Hits	228	Target Neighborhood Hits	235	Shared Neighborhood Hits	118
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

DUET_HUMAN
θ value	4.92598e-06 (rank : 53)	NC score	0.183966 (rank : 99)
Query Neighborhood Hits	228	Target Neighborhood Hits	1220	Shared Neighborhood Hits	101
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

VAV3_MOUSE
θ value	1.09739e-05 (rank : 54)	NC score	0.468033 (rank : 55)
Query Neighborhood Hits	228	Target Neighborhood Hits	404	Shared Neighborhood Hits	130
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

HAPIP_HUMAN
θ value	2.44474e-05 (rank : 55)	NC score	0.400170 (rank : 61)
Query Neighborhood Hits	228	Target Neighborhood Hits	350	Shared Neighborhood Hits	72
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

VAV3_HUMAN
θ value	4.1701e-05 (rank : 56)	NC score	0.464017 (rank : 57)
Query Neighborhood Hits	228	Target Neighborhood Hits	398	Shared Neighborhood Hits	127
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

SRBS1_MOUSE
θ value	5.44631e-05 (rank : 57)	NC score	0.287354 (rank : 71)
Query Neighborhood Hits	228	Target Neighborhood Hits	409	Shared Neighborhood Hits	102
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

MCF2_HUMAN
θ value	9.29e-05 (rank : 58)	NC score	0.485259 (rank : 51)
Query Neighborhood Hits	228	Target Neighborhood Hits	166	Shared Neighborhood Hits	68
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

SOS1_HUMAN
θ value	0.000121331 (rank : 59)	NC score	0.241684 (rank : 82)
Query Neighborhood Hits	228	Target Neighborhood Hits	274	Shared Neighborhood Hits	42
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

PLCG1_MOUSE
θ value	0.000158464 (rank : 60)	NC score	0.186686 (rank : 98)
Query Neighborhood Hits	228	Target Neighborhood Hits	314	Shared Neighborhood Hits	75
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

DNMBP_MOUSE
θ value	0.00020696 (rank : 61)	NC score	0.500154 (rank : 48)
Query Neighborhood Hits	228	Target Neighborhood Hits	435	Shared Neighborhood Hits	137
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

PPIP1_HUMAN
θ value	0.00020696 (rank : 62)	NC score	0.225393 (rank : 83)
Query Neighborhood Hits	228	Target Neighborhood Hits	389	Shared Neighborhood Hits	94
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PLCG1_HUMAN
θ value	0.000270298 (rank : 63)	NC score	0.179238 (rank : 103)
Query Neighborhood Hits	228	Target Neighborhood Hits	293	Shared Neighborhood Hits	73
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SRBS1_HUMAN
θ value	0.000270298 (rank : 64)	NC score	0.278456 (rank : 73)
Query Neighborhood Hits	228	Target Neighborhood Hits	396	Shared Neighborhood Hits	107
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

MCF2L_MOUSE
θ value	0.00035302 (rank : 65)	NC score	0.467313 (rank : 56)
Query Neighborhood Hits	228	Target Neighborhood Hits	255	Shared Neighborhood Hits	75
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

NCF1_MOUSE
θ value	0.000602161 (rank : 66)	NC score	0.274568 (rank : 76)
Query Neighborhood Hits	228	Target Neighborhood Hits	198	Shared Neighborhood Hits	79
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

TRIO_HUMAN
θ value	0.000602161 (rank : 67)	NC score	0.165722 (rank : 112)
Query Neighborhood Hits	228	Target Neighborhood Hits	1580	Shared Neighborhood Hits	113
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

CD2AP_HUMAN
θ value	0.00102713 (rank : 68)	NC score	0.276984 (rank : 74)
Query Neighborhood Hits	228	Target Neighborhood Hits	315	Shared Neighborhood Hits	93
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

MYO1F_HUMAN
θ value	0.00175202 (rank : 69)	NC score	0.101204 (rank : 178)
Query Neighborhood Hits	228	Target Neighborhood Hits	275	Shared Neighborhood Hits	79
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

CD2L1_MOUSE
θ value	0.00228821 (rank : 70)	NC score	0.010820 (rank : 353)
Query Neighborhood Hits	228	Target Neighborhood Hits	1463	Shared Neighborhood Hits	40
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

MYO1F_MOUSE
θ value	0.00228821 (rank : 71)	NC score	0.101500 (rank : 176)
Query Neighborhood Hits	228	Target Neighborhood Hits	262	Shared Neighborhood Hits	79
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

FXL19_HUMAN
θ value	0.00298849 (rank : 72)	NC score	0.050746 (rank : 287)
Query Neighborhood Hits	228	Target Neighborhood Hits	147	Shared Neighborhood Hits	7
SwissProt Accessions	Q6PCT2, Q8N789, Q9NT14	Gene names	FBXL19, FBL19
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19).

AHI1_HUMAN
θ value	0.00390308 (rank : 73)	NC score	0.170147 (rank : 107)
Query Neighborhood Hits	228	Target Neighborhood Hits	537	Shared Neighborhood Hits	86
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

CD2AP_MOUSE
θ value	0.00390308 (rank : 74)	NC score	0.274635 (rank : 75)
Query Neighborhood Hits	228	Target Neighborhood Hits	336	Shared Neighborhood Hits	94
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

FXL19_MOUSE
θ value	0.00390308 (rank : 75)	NC score	0.053692 (rank : 265)
Query Neighborhood Hits	228	Target Neighborhood Hits	217	Shared Neighborhood Hits	13
SwissProt Accessions	Q6PB97, Q7TSH0, Q8BIB4	Gene names	Fbxl19
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19).

NCF1_HUMAN
θ value	0.00390308 (rank : 76)	NC score	0.271301 (rank : 78)
Query Neighborhood Hits	228	Target Neighborhood Hits	198	Shared Neighborhood Hits	77
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

BI2L1_MOUSE
θ value	0.00509761 (rank : 77)	NC score	0.177911 (rank : 104)
Query Neighborhood Hits	228	Target Neighborhood Hits	197	Shared Neighborhood Hits	50
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

PPIP1_MOUSE
θ value	0.00665767 (rank : 78)	NC score	0.217783 (rank : 87)
Query Neighborhood Hits	228	Target Neighborhood Hits	377	Shared Neighborhood Hits	100
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

BI2L1_HUMAN
θ value	0.00869519 (rank : 79)	NC score	0.195039 (rank : 93)
Query Neighborhood Hits	228	Target Neighborhood Hits	156	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

NCK2_HUMAN
θ value	0.00869519 (rank : 80)	NC score	0.223176 (rank : 84)
Query Neighborhood Hits	228	Target Neighborhood Hits	310	Shared Neighborhood Hits	86
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

SNIP1_HUMAN
θ value	0.00869519 (rank : 81)	NC score	0.050560 (rank : 288)
Query Neighborhood Hits	228	Target Neighborhood Hits	80	Shared Neighborhood Hits	9
SwissProt Accessions	Q8TAD8, Q96SP9, Q9H9T7	Gene names	SNIP1
Domain Architecture
Description	Smad nuclear-interacting protein 1.

AHI1_MOUSE
θ value	0.0193708 (rank : 82)	NC score	0.167036 (rank : 109)
Query Neighborhood Hits	228	Target Neighborhood Hits	496	Shared Neighborhood Hits	85
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

BIN1_HUMAN
θ value	0.0193708 (rank : 83)	NC score	0.134485 (rank : 154)
Query Neighborhood Hits	228	Target Neighborhood Hits	335	Shared Neighborhood Hits	69
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BIN1_MOUSE
θ value	0.0193708 (rank : 84)	NC score	0.138979 (rank : 149)
Query Neighborhood Hits	228	Target Neighborhood Hits	283	Shared Neighborhood Hits	69
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

RAI14_MOUSE
θ value	0.0193708 (rank : 85)	NC score	0.023528 (rank : 323)
Query Neighborhood Hits	228	Target Neighborhood Hits	1505	Shared Neighborhood Hits	44
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

DNMBP_HUMAN
θ value	0.0252991 (rank : 86)	NC score	0.472795 (rank : 53)
Query Neighborhood Hits	228	Target Neighborhood Hits	413	Shared Neighborhood Hits	137
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

SH3K1_HUMAN
θ value	0.0252991 (rank : 87)	NC score	0.279953 (rank : 72)
Query Neighborhood Hits	228	Target Neighborhood Hits	341	Shared Neighborhood Hits	94
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	0.0252991 (rank : 88)	NC score	0.271440 (rank : 77)
Query Neighborhood Hits	228	Target Neighborhood Hits	332	Shared Neighborhood Hits	95
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

NCK1_HUMAN
θ value	0.0330416 (rank : 89)	NC score	0.222881 (rank : 85)
Query Neighborhood Hits	228	Target Neighborhood Hits	312	Shared Neighborhood Hits	90
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SOS1_MOUSE
θ value	0.0330416 (rank : 90)	NC score	0.220609 (rank : 86)
Query Neighborhood Hits	228	Target Neighborhood Hits	281	Shared Neighborhood Hits	43
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

AFF4_HUMAN
θ value	0.0431538 (rank : 91)	NC score	0.042302 (rank : 295)
Query Neighborhood Hits	228	Target Neighborhood Hits	611	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UHB7, Q498B2, Q59FB3, Q6P592, Q8TDR1, Q9P0E4	Gene names	AFF4, AF5Q31, MCEF
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31) (Major CDK9 elongation factor-associated protein).

TCGAP_HUMAN
θ value	0.0431538 (rank : 92)	NC score	0.114614 (rank : 164)
Query Neighborhood Hits	228	Target Neighborhood Hits	872	Shared Neighborhood Hits	93
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	0.0431538 (rank : 93)	NC score	0.127554 (rank : 157)
Query Neighborhood Hits	228	Target Neighborhood Hits	409	Shared Neighborhood Hits	81
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SRRM1_MOUSE
θ value	0.0563607 (rank : 94)	NC score	0.058838 (rank : 252)
Query Neighborhood Hits	228	Target Neighborhood Hits	966	Shared Neighborhood Hits	55
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

ABL1_HUMAN
θ value	0.0736092 (rank : 95)	NC score	0.028347 (rank : 316)
Query Neighborhood Hits	228	Target Neighborhood Hits	1220	Shared Neighborhood Hits	79
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ARHG7_MOUSE
θ value	0.0961366 (rank : 96)	NC score	0.428080 (rank : 58)
Query Neighborhood Hits	228	Target Neighborhood Hits	396	Shared Neighborhood Hits	125
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

BCR_HUMAN
θ value	0.0961366 (rank : 97)	NC score	0.322927 (rank : 68)
Query Neighborhood Hits	228	Target Neighborhood Hits	204	Shared Neighborhood Hits	65
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

MYO1E_HUMAN
θ value	0.0961366 (rank : 98)	NC score	0.098216 (rank : 185)
Query Neighborhood Hits	228	Target Neighborhood Hits	293	Shared Neighborhood Hits	84
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

VINEX_HUMAN
θ value	0.0961366 (rank : 99)	NC score	0.254181 (rank : 79)
Query Neighborhood Hits	228	Target Neighborhood Hits	270	Shared Neighborhood Hits	95
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	0.0961366 (rank : 100)	NC score	0.248862 (rank : 81)
Query Neighborhood Hits	228	Target Neighborhood Hits	286	Shared Neighborhood Hits	94
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ABI1_MOUSE
θ value	0.125558 (rank : 101)	NC score	0.213666 (rank : 89)
Query Neighborhood Hits	228	Target Neighborhood Hits	246	Shared Neighborhood Hits	84
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

SRRM1_HUMAN
θ value	0.125558 (rank : 102)	NC score	0.050050 (rank : 293)
Query Neighborhood Hits	228	Target Neighborhood Hits	690	Shared Neighborhood Hits	46
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

NCF2_HUMAN
θ value	0.163984 (rank : 103)	NC score	0.253968 (rank : 80)
Query Neighborhood Hits	228	Target Neighborhood Hits	229	Shared Neighborhood Hits	85
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

ABI2_HUMAN
θ value	0.21417 (rank : 104)	NC score	0.212229 (rank : 91)
Query Neighborhood Hits	228	Target Neighborhood Hits	350	Shared Neighborhood Hits	85
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	0.21417 (rank : 105)	NC score	0.214332 (rank : 88)
Query Neighborhood Hits	228	Target Neighborhood Hits	266	Shared Neighborhood Hits	84
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

JIP2_HUMAN
θ value	0.21417 (rank : 106)	NC score	0.115928 (rank : 162)
Query Neighborhood Hits	228	Target Neighborhood Hits	288	Shared Neighborhood Hits	51
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JIP2_MOUSE
θ value	0.21417 (rank : 107)	NC score	0.113309 (rank : 165)
Query Neighborhood Hits	228	Target Neighborhood Hits	144	Shared Neighborhood Hits	41
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

NFH_HUMAN
θ value	0.21417 (rank : 108)	NC score	0.020054 (rank : 332)
Query Neighborhood Hits	228	Target Neighborhood Hits	1242	Shared Neighborhood Hits	47
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

SRRM2_MOUSE
θ value	0.21417 (rank : 109)	NC score	0.051797 (rank : 276)
Query Neighborhood Hits	228	Target Neighborhood Hits	1470	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

ZC313_HUMAN
θ value	0.21417 (rank : 110)	NC score	0.056928 (rank : 256)
Query Neighborhood Hits	228	Target Neighborhood Hits	772	Shared Neighborhood Hits	34
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

CENPH_MOUSE
θ value	0.279714 (rank : 111)	NC score	0.050270 (rank : 290)
Query Neighborhood Hits	228	Target Neighborhood Hits	195	Shared Neighborhood Hits	10
SwissProt Accessions	Q9QYM8, Q8R3K9, Q9D079, Q9D0N1	Gene names	Cenph, Enp
Domain Architecture	No domain graphic available
Description	Centromere protein H (CENP-H).

MINT_HUMAN
θ value	0.279714 (rank : 112)	NC score	0.038522 (rank : 298)
Query Neighborhood Hits	228	Target Neighborhood Hits	1291	Shared Neighborhood Hits	55
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

MUC7_HUMAN
θ value	0.279714 (rank : 113)	NC score	0.037491 (rank : 300)
Query Neighborhood Hits	228	Target Neighborhood Hits	538	Shared Neighborhood Hits	26
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

NFH_MOUSE
θ value	0.279714 (rank : 114)	NC score	0.031903 (rank : 309)
Query Neighborhood Hits	228	Target Neighborhood Hits	2247	Shared Neighborhood Hits	86
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

ABI1_HUMAN
θ value	0.365318 (rank : 115)	NC score	0.202948 (rank : 92)
Query Neighborhood Hits	228	Target Neighborhood Hits	257	Shared Neighborhood Hits	84
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABR_HUMAN
θ value	0.365318 (rank : 116)	NC score	0.314808 (rank : 69)
Query Neighborhood Hits	228	Target Neighborhood Hits	166	Shared Neighborhood Hits	64
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

AFF4_MOUSE
θ value	0.365318 (rank : 117)	NC score	0.040509 (rank : 296)
Query Neighborhood Hits	228	Target Neighborhood Hits	581	Shared Neighborhood Hits	34
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

BRCA1_HUMAN
θ value	0.365318 (rank : 118)	NC score	0.020232 (rank : 331)
Query Neighborhood Hits	228	Target Neighborhood Hits	381	Shared Neighborhood Hits	10
SwissProt Accessions	P38398	Gene names	BRCA1, RNF53
Domain Architecture
Description	Breast cancer type 1 susceptibility protein (RING finger protein 53).

TCOF_HUMAN
θ value	0.365318 (rank : 119)	NC score	0.035868 (rank : 305)
Query Neighborhood Hits	228	Target Neighborhood Hits	543	Shared Neighborhood Hits	27
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

CJ047_HUMAN
θ value	0.47712 (rank : 120)	NC score	0.031426 (rank : 310)
Query Neighborhood Hits	228	Target Neighborhood Hits	164	Shared Neighborhood Hits	10
SwissProt Accessions	Q86WR7, Q5W0J9, Q5W0K0, Q5W0K1, Q5W0K2, Q6PJC8, Q8N317	Gene names	C10orf47
Domain Architecture	No domain graphic available
Description	Protein C10orf47.

KIF1A_MOUSE
θ value	0.47712 (rank : 121)	NC score	0.016487 (rank : 340)
Query Neighborhood Hits	228	Target Neighborhood Hits	239	Shared Neighborhood Hits	16
SwissProt Accessions	P33173, Q61770	Gene names	Kif1a, Atsv, Kif1
Domain Architecture
Description	Kinesin-like protein KIF1A (Axonal transporter of synaptic vesicles).

NPHP1_MOUSE
θ value	0.47712 (rank : 122)	NC score	0.152001 (rank : 133)
Query Neighborhood Hits	228	Target Neighborhood Hits	267	Shared Neighborhood Hits	72
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

PACN1_HUMAN
θ value	0.47712 (rank : 123)	NC score	0.154944 (rank : 128)
Query Neighborhood Hits	228	Target Neighborhood Hits	320	Shared Neighborhood Hits	85
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	0.47712 (rank : 124)	NC score	0.154223 (rank : 129)
Query Neighborhood Hits	228	Target Neighborhood Hits	283	Shared Neighborhood Hits	83
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

RIMS1_HUMAN
θ value	0.47712 (rank : 125)	NC score	0.029236 (rank : 314)
Query Neighborhood Hits	228	Target Neighborhood Hits	437	Shared Neighborhood Hits	22
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

TF3C1_HUMAN
θ value	0.47712 (rank : 126)	NC score	0.027677 (rank : 317)
Query Neighborhood Hits	228	Target Neighborhood Hits	88	Shared Neighborhood Hits	9
SwissProt Accessions	Q12789, Q12838, Q9Y4W9	Gene names	GTF3C1
Domain Architecture	No domain graphic available
Description	General transcription factor 3C polypeptide 1 (Transcription factor IIIC-subunit alpha) (TF3C-alpha) (TFIIIC 220 kDa subunit) (TFIIIC220) (TFIIIC box B-binding subunit).

BAIP2_HUMAN
θ value	0.62314 (rank : 127)	NC score	0.143539 (rank : 144)
Query Neighborhood Hits	228	Target Neighborhood Hits	192	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	0.62314 (rank : 128)	NC score	0.144692 (rank : 141)
Query Neighborhood Hits	228	Target Neighborhood Hits	185	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

CIR_MOUSE
θ value	0.62314 (rank : 129)	NC score	0.030132 (rank : 312)
Query Neighborhood Hits	228	Target Neighborhood Hits	255	Shared Neighborhood Hits	14
SwissProt Accessions	Q9DA19, Q3V2N9, Q4KL44, Q52KL9, Q5FW66	Gene names	Cir
Domain Architecture	No domain graphic available
Description	CBF1-interacting corepressor.

DOCK1_HUMAN
θ value	0.62314 (rank : 130)	NC score	0.080290 (rank : 211)
Query Neighborhood Hits	228	Target Neighborhood Hits	191	Shared Neighborhood Hits	66
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

LASP1_HUMAN
θ value	0.62314 (rank : 131)	NC score	0.191978 (rank : 94)
Query Neighborhood Hits	228	Target Neighborhood Hits	293	Shared Neighborhood Hits	82
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	0.62314 (rank : 132)	NC score	0.189010 (rank : 97)
Query Neighborhood Hits	228	Target Neighborhood Hits	297	Shared Neighborhood Hits	82
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

PRR12_HUMAN
θ value	0.62314 (rank : 133)	NC score	0.037319 (rank : 302)
Query Neighborhood Hits	228	Target Neighborhood Hits	460	Shared Neighborhood Hits	30
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

SFR11_HUMAN
θ value	0.62314 (rank : 134)	NC score	0.037224 (rank : 303)
Query Neighborhood Hits	228	Target Neighborhood Hits	246	Shared Neighborhood Hits	21
SwissProt Accessions	Q05519	Gene names	SFRS11
Domain Architecture
Description	Splicing factor arginine/serine-rich 11 (Arginine-rich 54 kDa nuclear protein) (p54).

SHAN1_HUMAN
θ value	0.62314 (rank : 135)	NC score	0.097994 (rank : 186)
Query Neighborhood Hits	228	Target Neighborhood Hits	1041	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

GEMI5_MOUSE
θ value	0.813845 (rank : 136)	NC score	0.012887 (rank : 349)
Query Neighborhood Hits	228	Target Neighborhood Hits	424	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BX17	Gene names	Gemin5
Domain Architecture
Description	Gem-associated protein 5 (Gemin5).

PACN2_HUMAN
θ value	0.813845 (rank : 137)	NC score	0.156768 (rank : 127)
Query Neighborhood Hits	228	Target Neighborhood Hits	339	Shared Neighborhood Hits	90
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

ABI3_MOUSE
θ value	1.06291 (rank : 138)	NC score	0.190961 (rank : 96)
Query Neighborhood Hits	228	Target Neighborhood Hits	227	Shared Neighborhood Hits	78
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

CN045_HUMAN
θ value	1.06291 (rank : 139)	NC score	0.038722 (rank : 297)
Query Neighborhood Hits	228	Target Neighborhood Hits	227	Shared Neighborhood Hits	10
SwissProt Accessions	Q8ND07, Q9H5P8	Gene names	C14orf45
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf45.

PACN2_MOUSE
θ value	1.06291 (rank : 140)	NC score	0.161691 (rank : 122)
Query Neighborhood Hits	228	Target Neighborhood Hits	382	Shared Neighborhood Hits	95
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PXK_MOUSE
θ value	1.06291 (rank : 141)	NC score	0.015344 (rank : 343)
Query Neighborhood Hits	228	Target Neighborhood Hits	320	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

SNPC4_HUMAN
θ value	1.06291 (rank : 142)	NC score	0.028866 (rank : 315)
Query Neighborhood Hits	228	Target Neighborhood Hits	589	Shared Neighborhood Hits	23
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

STAM2_MOUSE
θ value	1.06291 (rank : 143)	NC score	0.162178 (rank : 121)
Query Neighborhood Hits	228	Target Neighborhood Hits	285	Shared Neighborhood Hits	78
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

ZN238_HUMAN
θ value	1.06291 (rank : 144)	NC score	-0.003727 (rank : 374)
Query Neighborhood Hits	228	Target Neighborhood Hits	836	Shared Neighborhood Hits	7
SwissProt Accessions	Q99592, Q13397, Q5VU40, Q8N463	Gene names	ZNF238, RP58, TAZ1, ZBTB18
Domain Architecture
Description	Zinc finger protein 238 (Transcriptional repressor RP58) (58 kDa repressor protein) (Zinc finger protein C2H2-171) (Translin-associated zinc finger protein 1) (TAZ-1) (Zinc finger and BTB domain-containing protein 18).

ABI3_HUMAN
θ value	1.38821 (rank : 145)	NC score	0.191827 (rank : 95)
Query Neighborhood Hits	228	Target Neighborhood Hits	227	Shared Neighborhood Hits	75
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

BSCL2_HUMAN
θ value	1.38821 (rank : 146)	NC score	0.021933 (rank : 328)
Query Neighborhood Hits	228	Target Neighborhood Hits	148	Shared Neighborhood Hits	7
SwissProt Accessions	Q96G97, Q96SV1, Q9BSQ0	Gene names	BSCL2
Domain Architecture	No domain graphic available
Description	Seipin (Bernardinelli-Seip congenital lipodystrophy type 2 protein).

CCD96_MOUSE
θ value	1.38821 (rank : 147)	NC score	0.047139 (rank : 294)
Query Neighborhood Hits	228	Target Neighborhood Hits	704	Shared Neighborhood Hits	32
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

KIF1A_HUMAN
θ value	1.38821 (rank : 148)	NC score	0.015004 (rank : 344)
Query Neighborhood Hits	228	Target Neighborhood Hits	240	Shared Neighborhood Hits	16
SwissProt Accessions	Q12756	Gene names	KIF1A, ATSV
Domain Architecture
Description	Kinesin-like protein KIF1A (Axonal transporter of synaptic vesicles).

PAK3_MOUSE
θ value	1.38821 (rank : 149)	NC score	0.001649 (rank : 373)
Query Neighborhood Hits	228	Target Neighborhood Hits	874	Shared Neighborhood Hits	20
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

RASA1_HUMAN
θ value	1.38821 (rank : 150)	NC score	0.051183 (rank : 284)
Query Neighborhood Hits	228	Target Neighborhood Hits	258	Shared Neighborhood Hits	36
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RBMX2_HUMAN
θ value	1.38821 (rank : 151)	NC score	0.011690 (rank : 350)
Query Neighborhood Hits	228	Target Neighborhood Hits	351	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y388, Q5JY82, Q9Y3I8	Gene names	RBMX2
Domain Architecture
Description	RNA-binding motif protein, X-linked 2.

RILP_HUMAN
θ value	1.38821 (rank : 152)	NC score	0.032781 (rank : 308)
Query Neighborhood Hits	228	Target Neighborhood Hits	249	Shared Neighborhood Hits	16
SwissProt Accessions	Q96NA2, Q71RE6, Q9BSL3, Q9BYS3	Gene names	RILP
Domain Architecture	No domain graphic available
Description	Rab-interacting lysosomal protein.

DAAM1_HUMAN
θ value	1.81305 (rank : 153)	NC score	0.021879 (rank : 329)
Query Neighborhood Hits	228	Target Neighborhood Hits	483	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y4D1, Q86U34, Q8N1Z8, Q8TB39	Gene names	DAAM1, KIAA0666
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 1.

DAAM1_MOUSE
θ value	1.81305 (rank : 154)	NC score	0.024828 (rank : 319)
Query Neighborhood Hits	228	Target Neighborhood Hits	443	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BPM0, Q80Y68, Q9CQQ2	Gene names	Daam1
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 1.

K2027_HUMAN
θ value	1.81305 (rank : 155)	NC score	0.023732 (rank : 322)
Query Neighborhood Hits	228	Target Neighborhood Hits	194	Shared Neighborhood Hits	17
SwissProt Accessions	Q6ZVF9, Q8IVE4	Gene names	KIAA2027
Domain Architecture	No domain graphic available
Description	Protein KIAA2027.

NEBU_HUMAN
θ value	1.81305 (rank : 156)	NC score	0.136427 (rank : 152)
Query Neighborhood Hits	228	Target Neighborhood Hits	420	Shared Neighborhood Hits	89
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

NEST_HUMAN
θ value	1.81305 (rank : 157)	NC score	0.034111 (rank : 306)
Query Neighborhood Hits	228	Target Neighborhood Hits	1305	Shared Neighborhood Hits	46
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

NOXO1_MOUSE
θ value	1.81305 (rank : 158)	NC score	0.152722 (rank : 132)
Query Neighborhood Hits	228	Target Neighborhood Hits	114	Shared Neighborhood Hits	54
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

ARHG7_HUMAN
θ value	2.36792 (rank : 159)	NC score	0.426467 (rank : 59)
Query Neighborhood Hits	228	Target Neighborhood Hits	347	Shared Neighborhood Hits	130
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

CTRO_HUMAN
θ value	2.36792 (rank : 160)	NC score	0.016072 (rank : 342)
Query Neighborhood Hits	228	Target Neighborhood Hits	2092	Shared Neighborhood Hits	64
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

CTRO_MOUSE
θ value	2.36792 (rank : 161)	NC score	0.018609 (rank : 335)
Query Neighborhood Hits	228	Target Neighborhood Hits	2344	Shared Neighborhood Hits	66
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

GRAP_HUMAN
θ value	2.36792 (rank : 162)	NC score	0.181524 (rank : 100)
Query Neighborhood Hits	228	Target Neighborhood Hits	307	Shared Neighborhood Hits	85
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

STAM2_HUMAN
θ value	2.36792 (rank : 163)	NC score	0.161024 (rank : 124)
Query Neighborhood Hits	228	Target Neighborhood Hits	288	Shared Neighborhood Hits	79
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

VASP_HUMAN
θ value	2.36792 (rank : 164)	NC score	0.017117 (rank : 338)
Query Neighborhood Hits	228	Target Neighborhood Hits	201	Shared Neighborhood Hits	12
SwissProt Accessions	P50552, Q6PIZ1, Q93035	Gene names	VASP
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

ZN238_MOUSE
θ value	2.36792 (rank : 165)	NC score	-0.004201 (rank : 375)
Query Neighborhood Hits	228	Target Neighborhood Hits	837	Shared Neighborhood Hits	7
SwissProt Accessions	Q9WUK6	Gene names	Znf238, Rp58, Zfp238
Domain Architecture
Description	Zinc finger protein 238 (Zfp-238) (Transcriptional repressor RP58) (58 kDa repressor protein).

ACK1_HUMAN
θ value	3.0926 (rank : 166)	NC score	0.008316 (rank : 356)
Query Neighborhood Hits	228	Target Neighborhood Hits	1140	Shared Neighborhood Hits	54
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	3.0926 (rank : 167)	NC score	0.008232 (rank : 357)
Query Neighborhood Hits	228	Target Neighborhood Hits	1080	Shared Neighborhood Hits	54
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

C8AP2_HUMAN
θ value	3.0926 (rank : 168)	NC score	0.029714 (rank : 313)
Query Neighborhood Hits	228	Target Neighborhood Hits	548	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UKL3, Q6PH76, Q7LCQ7, Q86YD9, Q9NUQ4, Q9NZV9, Q9P2N1, Q9Y563	Gene names	CASP8AP2, FLASH, KIAA1315, RIP25
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

LRSM1_HUMAN
θ value	3.0926 (rank : 169)	NC score	0.017331 (rank : 337)
Query Neighborhood Hits	228	Target Neighborhood Hits	1078	Shared Neighborhood Hits	31
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

MCM3A_HUMAN
θ value	3.0926 (rank : 170)	NC score	0.013005 (rank : 348)
Query Neighborhood Hits	228	Target Neighborhood Hits	86	Shared Neighborhood Hits	5
SwissProt Accessions	O60318, Q9UMT4	Gene names	MCM3AP, GANP, KIAA0572, MAP80
Domain Architecture
Description	80 kDa MCM3-associated protein (GANP protein).

MRCKB_HUMAN
θ value	3.0926 (rank : 171)	NC score	0.021692 (rank : 330)
Query Neighborhood Hits	228	Target Neighborhood Hits	2239	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

NEBL_HUMAN
θ value	3.0926 (rank : 172)	NC score	0.164842 (rank : 115)
Query Neighborhood Hits	228	Target Neighborhood Hits	457	Shared Neighborhood Hits	94
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NRCAM_HUMAN
θ value	3.0926 (rank : 173)	NC score	0.007655 (rank : 360)
Query Neighborhood Hits	228	Target Neighborhood Hits	439	Shared Neighborhood Hits	10
SwissProt Accessions	Q92823, O15051, O15179, Q9UHI3, Q9UHI4	Gene names	NRCAM, KIAA0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (hBravo).

NRCAM_MOUSE
θ value	3.0926 (rank : 174)	NC score	0.007486 (rank : 363)
Query Neighborhood Hits	228	Target Neighborhood Hits	432	Shared Neighborhood Hits	10
SwissProt Accessions	Q810U4, Q80U33, Q8BLG8, Q8BX92, Q8BYJ8	Gene names	Nrcam, Kiaa0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (mBravo).

PACN3_HUMAN
θ value	3.0926 (rank : 175)	NC score	0.152831 (rank : 131)
Query Neighborhood Hits	228	Target Neighborhood Hits	385	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	3.0926 (rank : 176)	NC score	0.153315 (rank : 130)
Query Neighborhood Hits	228	Target Neighborhood Hits	380	Shared Neighborhood Hits	78
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PRP4B_MOUSE
θ value	3.0926 (rank : 177)	NC score	0.006388 (rank : 367)
Query Neighborhood Hits	228	Target Neighborhood Hits	1040	Shared Neighborhood Hits	32
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

SHE_MOUSE
θ value	3.0926 (rank : 178)	NC score	0.053786 (rank : 264)
Query Neighborhood Hits	228	Target Neighborhood Hits	169	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

STS1_HUMAN
θ value	3.0926 (rank : 179)	NC score	0.092659 (rank : 193)
Query Neighborhood Hits	228	Target Neighborhood Hits	106	Shared Neighborhood Hits	53
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

T240L_MOUSE
θ value	3.0926 (rank : 180)	NC score	0.014382 (rank : 347)
Query Neighborhood Hits	228	Target Neighborhood Hits	143	Shared Neighborhood Hits	7
SwissProt Accessions	Q6JPI3, Q3TRF4, Q3UQI8, Q80TM3, Q80WQ0	Gene names	Thrap2, Kiaa1025, Trap240l
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 2 (Thyroid hormone receptor-associated protein complex 240 kDa component-like).

FGD5_MOUSE
θ value	4.03905 (rank : 181)	NC score	0.370044 (rank : 66)
Query Neighborhood Hits	228	Target Neighborhood Hits	170	Shared Neighborhood Hits	49
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

K1802_MOUSE
θ value	4.03905 (rank : 182)	NC score	0.024344 (rank : 320)
Query Neighborhood Hits	228	Target Neighborhood Hits	1596	Shared Neighborhood Hits	57
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

NPHP1_HUMAN
θ value	4.03905 (rank : 183)	NC score	0.137188 (rank : 151)
Query Neighborhood Hits	228	Target Neighborhood Hits	288	Shared Neighborhood Hits	74
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

PHF14_MOUSE
θ value	4.03905 (rank : 184)	NC score	0.007375 (rank : 364)
Query Neighborhood Hits	228	Target Neighborhood Hits	342	Shared Neighborhood Hits	15
SwissProt Accessions	Q9D4H9, Q810Z6, Q8C284, Q8CGF8, Q9D1Q8	Gene names	Phf14
Domain Architecture
Description	PHD finger protein 14.

SFR12_HUMAN
θ value	4.03905 (rank : 185)	NC score	0.033545 (rank : 307)
Query Neighborhood Hits	228	Target Neighborhood Hits	553	Shared Neighborhood Hits	32
SwissProt Accessions	Q8WXA9, Q86X37	Gene names	SFRS12, SRRP86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86) (Splicing regulatory protein 508) (SRrp508).

SMG7_MOUSE
θ value	4.03905 (rank : 186)	NC score	0.017440 (rank : 336)
Query Neighborhood Hits	228	Target Neighborhood Hits	113	Shared Neighborhood Hits	9
SwissProt Accessions	Q5RJH6, Q63ZW5, Q6ZQF3	Gene names	Smg7, Est1c, Kiaa0250
Domain Architecture	No domain graphic available
Description	Protein SMG7 (SMG-7 homolog) (EST1-like protein C).

SRRM2_HUMAN
θ value	4.03905 (rank : 187)	NC score	0.037391 (rank : 301)
Query Neighborhood Hits	228	Target Neighborhood Hits	1296	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

AMPH_HUMAN
θ value	5.27518 (rank : 188)	NC score	0.114842 (rank : 163)
Query Neighborhood Hits	228	Target Neighborhood Hits	455	Shared Neighborhood Hits	74
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

ARHG6_MOUSE
θ value	5.27518 (rank : 189)	NC score	0.370608 (rank : 65)
Query Neighborhood Hits	228	Target Neighborhood Hits	394	Shared Neighborhood Hits	122
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

CIZ1_HUMAN
θ value	5.27518 (rank : 190)	NC score	0.014616 (rank : 345)
Query Neighborhood Hits	228	Target Neighborhood Hits	359	Shared Neighborhood Hits	19
SwissProt Accessions	Q9ULV3, Q9NYM8, Q9UHK4, Q9Y3F9, Q9Y3G0	Gene names	CIZ1, LSFR1, NP94
Domain Architecture	No domain graphic available
Description	Cip1-interacting zinc finger protein (Nuclear protein NP94).

DOCK4_HUMAN
θ value	5.27518 (rank : 191)	NC score	0.024178 (rank : 321)
Query Neighborhood Hits	228	Target Neighborhood Hits	237	Shared Neighborhood Hits	26
SwissProt Accessions	Q8N1I0, O14584, O94824, Q8NB45	Gene names	DOCK4, KIAA0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

DOCK4_MOUSE
θ value	5.27518 (rank : 192)	NC score	0.023452 (rank : 324)
Query Neighborhood Hits	228	Target Neighborhood Hits	210	Shared Neighborhood Hits	28
SwissProt Accessions	P59764	Gene names	Dock4, Kiaa0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

GCC2_HUMAN
θ value	5.27518 (rank : 193)	NC score	0.022586 (rank : 327)
Query Neighborhood Hits	228	Target Neighborhood Hits	1558	Shared Neighborhood Hits	49
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

MRCKB_MOUSE
θ value	5.27518 (rank : 194)	NC score	0.023054 (rank : 325)
Query Neighborhood Hits	228	Target Neighborhood Hits	2180	Shared Neighborhood Hits	71
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

OSBL5_HUMAN
θ value	5.27518 (rank : 195)	NC score	0.006841 (rank : 365)
Query Neighborhood Hits	228	Target Neighborhood Hits	117	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H0X9, Q9BZB0, Q9P1Z4	Gene names	OSBPL5, KIAA1534, ORP5
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5).

RBP24_HUMAN
θ value	5.27518 (rank : 196)	NC score	0.022636 (rank : 326)
Query Neighborhood Hits	228	Target Neighborhood Hits	1559	Shared Neighborhood Hits	49
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

SH3G1_HUMAN
θ value	5.27518 (rank : 197)	NC score	0.150809 (rank : 135)
Query Neighborhood Hits	228	Target Neighborhood Hits	307	Shared Neighborhood Hits	84
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

STS1_MOUSE
θ value	5.27518 (rank : 198)	NC score	0.088652 (rank : 198)
Query Neighborhood Hits	228	Target Neighborhood Hits	104	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

3BP1_MOUSE
θ value	6.88961 (rank : 199)	NC score	0.019444 (rank : 334)
Query Neighborhood Hits	228	Target Neighborhood Hits	238	Shared Neighborhood Hits	19
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

ANR38_HUMAN
θ value	6.88961 (rank : 200)	NC score	0.006459 (rank : 366)
Query Neighborhood Hits	228	Target Neighborhood Hits	443	Shared Neighborhood Hits	15
SwissProt Accessions	Q5T7N3, Q6P9A0, Q86T71, Q86VE6, Q8NAX3	Gene names	ANKRD38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

AQR_HUMAN
θ value	6.88961 (rank : 201)	NC score	0.008836 (rank : 355)
Query Neighborhood Hits	228	Target Neighborhood Hits	88	Shared Neighborhood Hits	7
SwissProt Accessions	O60306, Q2YDX9, Q6IRU8, Q6PIC8	Gene names	AQR, KIAA0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius (Intron-binding protein of 160 kDa) (IBP160).

ARHG6_HUMAN
θ value	6.88961 (rank : 202)	NC score	0.388556 (rank : 63)
Query Neighborhood Hits	228	Target Neighborhood Hits	376	Shared Neighborhood Hits	124
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARI5B_HUMAN
θ value	6.88961 (rank : 203)	NC score	0.016253 (rank : 341)
Query Neighborhood Hits	228	Target Neighborhood Hits	328	Shared Neighborhood Hits	23
SwissProt Accessions	Q14865, Q7Z3M4, Q8N421, Q9H786	Gene names	ARID5B, DESRT, MRF2
Domain Architecture
Description	AT-rich interactive domain-containing protein 5B (ARID domain- containing protein 5B) (Mrf1-like) (Modulator recognition factor 2) (MRF-2).

FGR_MOUSE
θ value	6.88961 (rank : 204)	NC score	0.037824 (rank : 299)
Query Neighborhood Hits	228	Target Neighborhood Hits	1069	Shared Neighborhood Hits	89
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

JIP1_HUMAN
θ value	6.88961 (rank : 205)	NC score	0.076322 (rank : 218)
Query Neighborhood Hits	228	Target Neighborhood Hits	271	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP1_MOUSE
θ value	6.88961 (rank : 206)	NC score	0.073302 (rank : 221)
Query Neighborhood Hits	228	Target Neighborhood Hits	259	Shared Neighborhood Hits	44
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

NFASC_HUMAN
θ value	6.88961 (rank : 207)	NC score	0.007538 (rank : 362)
Query Neighborhood Hits	228	Target Neighborhood Hits	497	Shared Neighborhood Hits	11
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

NFASC_MOUSE
θ value	6.88961 (rank : 208)	NC score	0.007756 (rank : 358)
Query Neighborhood Hits	228	Target Neighborhood Hits	475	Shared Neighborhood Hits	10
SwissProt Accessions	Q810U3	Gene names	Nfasc
Domain Architecture
Description	Neurofascin precursor.

NKRF_HUMAN
θ value	6.88961 (rank : 209)	NC score	0.007546 (rank : 361)
Query Neighborhood Hits	228	Target Neighborhood Hits	57	Shared Neighborhood Hits	2
SwissProt Accessions	O15226, Q9UJ91	Gene names	NKRF, ITBA4, NRF
Domain Architecture
Description	NF-kappa-B-repressing factor (NFKB-repressing factor) (Transcription factor NRF) (ITBA4 protein).

SHAN2_MOUSE
θ value	6.88961 (rank : 210)	NC score	0.116657 (rank : 161)
Query Neighborhood Hits	228	Target Neighborhood Hits	446	Shared Neighborhood Hits	71
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

TGON2_HUMAN
θ value	6.88961 (rank : 211)	NC score	0.030697 (rank : 311)
Query Neighborhood Hits	228	Target Neighborhood Hits	1037	Shared Neighborhood Hits	57
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

ZN516_HUMAN
θ value	6.88961 (rank : 212)	NC score	-0.005499 (rank : 376)
Query Neighborhood Hits	228	Target Neighborhood Hits	854	Shared Neighborhood Hits	11
SwissProt Accessions	Q92618	Gene names	ZNF516, KIAA0222
Domain Architecture	No domain graphic available
Description	Zinc finger protein 516.

AFAD_HUMAN
θ value	8.99809 (rank : 213)	NC score	0.027526 (rank : 318)
Query Neighborhood Hits	228	Target Neighborhood Hits	689	Shared Neighborhood Hits	30
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

BCAR1_MOUSE
θ value	8.99809 (rank : 214)	NC score	0.111162 (rank : 167)
Query Neighborhood Hits	228	Target Neighborhood Hits	438	Shared Neighborhood Hits	79
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

FOSL1_MOUSE
θ value	8.99809 (rank : 215)	NC score	0.005860 (rank : 370)
Query Neighborhood Hits	228	Target Neighborhood Hits	113	Shared Neighborhood Hits	4
SwissProt Accessions	P48755, O35285	Gene names	Fosl1, Fra1
Domain Architecture
Description	Fos-related antigen 1 (FRA-1).

GRAP_MOUSE
θ value	8.99809 (rank : 216)	NC score	0.181522 (rank : 101)
Query Neighborhood Hits	228	Target Neighborhood Hits	309	Shared Neighborhood Hits	88
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

L1CAM_HUMAN
θ value	8.99809 (rank : 217)	NC score	0.006288 (rank : 368)
Query Neighborhood Hits	228	Target Neighborhood Hits	457	Shared Neighborhood Hits	9
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

L1CAM_MOUSE
θ value	8.99809 (rank : 218)	NC score	0.006223 (rank : 369)
Query Neighborhood Hits	228	Target Neighborhood Hits	457	Shared Neighborhood Hits	9
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

NFM_MOUSE
θ value	8.99809 (rank : 219)	NC score	0.016642 (rank : 339)
Query Neighborhood Hits	228	Target Neighborhood Hits	1159	Shared Neighborhood Hits	45
SwissProt Accessions	P08553, Q61961	Gene names	Nef3, Nefm, Nfm
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M).

NPBL_MOUSE
θ value	8.99809 (rank : 220)	NC score	0.037039 (rank : 304)
Query Neighborhood Hits	228	Target Neighborhood Hits	1041	Shared Neighborhood Hits	50
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

PIWL3_HUMAN
θ value	8.99809 (rank : 221)	NC score	0.003363 (rank : 372)
Query Neighborhood Hits	228	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z3Z3	Gene names	PIWIL3
Domain Architecture	No domain graphic available
Description	Piwi-like protein 3.

PRG4_HUMAN
θ value	8.99809 (rank : 222)	NC score	0.020007 (rank : 333)
Query Neighborhood Hits	228	Target Neighborhood Hits	764	Shared Neighborhood Hits	31
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

RBM28_MOUSE
θ value	8.99809 (rank : 223)	NC score	0.007658 (rank : 359)
Query Neighborhood Hits	228	Target Neighborhood Hits	368	Shared Neighborhood Hits	22
SwissProt Accessions	Q8CGC6, Q8BG25, Q8VEJ8, Q9CS22, Q9CSE6	Gene names	Rbm28
Domain Architecture	No domain graphic available
Description	RNA-binding protein 28 (RNA-binding motif protein 28).

RNPS1_HUMAN
θ value	8.99809 (rank : 224)	NC score	0.011313 (rank : 351)
Query Neighborhood Hits	228	Target Neighborhood Hits	285	Shared Neighborhood Hits	14
SwissProt Accessions	Q15287, O75308, Q8WY42, Q9NYG3	Gene names	RNPS1, LDC2
Domain Architecture	No domain graphic available
Description	RNA-binding protein with serine-rich domain 1 (SR-related protein LDC2).

RNPS1_MOUSE
θ value	8.99809 (rank : 225)	NC score	0.011313 (rank : 352)
Query Neighborhood Hits	228	Target Neighborhood Hits	285	Shared Neighborhood Hits	14
SwissProt Accessions	Q99M28, Q3TMJ1, Q922H8	Gene names	Rnps1
Domain Architecture	No domain graphic available
Description	RNA-binding protein with serine-rich domain 1.

SLK_MOUSE
θ value	8.99809 (rank : 226)	NC score	0.010009 (rank : 354)
Query Neighborhood Hits	228	Target Neighborhood Hits	1798	Shared Neighborhood Hits	47
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

SMG7_HUMAN
θ value	8.99809 (rank : 227)	NC score	0.014481 (rank : 346)
Query Neighborhood Hits	228	Target Neighborhood Hits	117	Shared Neighborhood Hits	9
SwissProt Accessions	Q92540, Q5T1Q0, Q6PIE0, Q7Z7H9, Q8IXC1, Q8IXC2	Gene names	SMG7, C1orf16, EST1C, KIAA0250
Domain Architecture
Description	Protein SMG7 (SMG-7 homolog) (EST1-like protein C).

WNK2_HUMAN
θ value	8.99809 (rank : 228)	NC score	0.004005 (rank : 371)
Query Neighborhood Hits	228	Target Neighborhood Hits	1407	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

ALS2_MOUSE
θ value	θ > 10 (rank : 229)	NC score	0.050128 (rank : 292)
Query Neighborhood Hits	228	Target Neighborhood Hits	111	Shared Neighborhood Hits	16
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

AMPH_MOUSE
θ value	θ > 10 (rank : 230)	NC score	0.099490 (rank : 181)
Query Neighborhood Hits	228	Target Neighborhood Hits	291	Shared Neighborhood Hits	57
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

ANM2_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.093497 (rank : 191)
Query Neighborhood Hits	228	Target Neighborhood Hits	175	Shared Neighborhood Hits	64
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 232)	NC score	0.090037 (rank : 195)
Query Neighborhood Hits	228	Target Neighborhood Hits	175	Shared Neighborhood Hits	61
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHGA_MOUSE
θ value	θ > 10 (rank : 233)	NC score	0.470092 (rank : 54)
Query Neighborhood Hits	228	Target Neighborhood Hits	125	Shared Neighborhood Hits	64
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ASPP1_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.067744 (rank : 228)
Query Neighborhood Hits	228	Target Neighborhood Hits	956	Shared Neighborhood Hits	87
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_MOUSE
θ value	θ > 10 (rank : 235)	NC score	0.075893 (rank : 219)
Query Neighborhood Hits	228	Target Neighborhood Hits	1244	Shared Neighborhood Hits	102
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP2_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.055036 (rank : 260)
Query Neighborhood Hits	228	Target Neighborhood Hits	1156	Shared Neighborhood Hits	81
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

BCAR1_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.104634 (rank : 172)
Query Neighborhood Hits	228	Target Neighborhood Hits	554	Shared Neighborhood Hits	80
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CASL_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.098532 (rank : 184)
Query Neighborhood Hits	228	Target Neighborhood Hits	259	Shared Neighborhood Hits	72
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	θ > 10 (rank : 239)	NC score	0.095624 (rank : 190)
Query Neighborhood Hits	228	Target Neighborhood Hits	225	Shared Neighborhood Hits	69
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CRKL_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.151346 (rank : 134)
Query Neighborhood Hits	228	Target Neighborhood Hits	313	Shared Neighborhood Hits	76
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 241)	NC score	0.148314 (rank : 139)
Query Neighborhood Hits	228	Target Neighborhood Hits	307	Shared Neighborhood Hits	75
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.136171 (rank : 153)
Query Neighborhood Hits	228	Target Neighborhood Hits	308	Shared Neighborhood Hits	77
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 243)	NC score	0.140482 (rank : 146)
Query Neighborhood Hits	228	Target Neighborhood Hits	314	Shared Neighborhood Hits	78
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CT032_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.107030 (rank : 170)
Query Neighborhood Hits	228	Target Neighborhood Hits	235	Shared Neighborhood Hits	68
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DAPP1_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.051405 (rank : 281)
Query Neighborhood Hits	228	Target Neighborhood Hits	227	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.051718 (rank : 277)
Query Neighborhood Hits	228	Target Neighborhood Hits	225	Shared Neighborhood Hits	18
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DBNL_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.132214 (rank : 155)
Query Neighborhood Hits	228	Target Neighborhood Hits	244	Shared Neighborhood Hits	75
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.126656 (rank : 158)
Query Neighborhood Hits	228	Target Neighborhood Hits	306	Shared Neighborhood Hits	73
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DDEF1_MOUSE
θ value	θ > 10 (rank : 249)	NC score	0.078262 (rank : 215)
Query Neighborhood Hits	228	Target Neighborhood Hits	592	Shared Neighborhood Hits	76
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.085377 (rank : 200)
Query Neighborhood Hits	228	Target Neighborhood Hits	599	Shared Neighborhood Hits	90
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	θ > 10 (rank : 251)	NC score	0.085393 (rank : 199)
Query Neighborhood Hits	228	Target Neighborhood Hits	625	Shared Neighborhood Hits	89
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

EEA1_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.053541 (rank : 266)
Query Neighborhood Hits	228	Target Neighborhood Hits	1796	Shared Neighborhood Hits	61
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

EEA1_MOUSE
θ value	θ > 10 (rank : 253)	NC score	0.053313 (rank : 269)
Query Neighborhood Hits	228	Target Neighborhood Hits	1637	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

EFS_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.103635 (rank : 173)
Query Neighborhood Hits	228	Target Neighborhood Hits	348	Shared Neighborhood Hits	79
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	θ > 10 (rank : 255)	NC score	0.112885 (rank : 166)
Query Neighborhood Hits	228	Target Neighborhood Hits	389	Shared Neighborhood Hits	80
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

EHD1_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.052126 (rank : 272)
Query Neighborhood Hits	228	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H4M9, O14611, Q9UNR3	Gene names	EHD1, PAST, PAST1
Domain Architecture
Description	EH-domain-containing protein 1 (Testilin) (hPAST1).

EHD1_MOUSE
θ value	θ > 10 (rank : 257)	NC score	0.052042 (rank : 273)
Query Neighborhood Hits	228	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WVK4	Gene names	Ehd1, Past1
Domain Architecture
Description	EH-domain-containing protein 1 (mPAST1).

EHD2_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.051485 (rank : 279)
Query Neighborhood Hits	228	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZN4, Q96CB6	Gene names	EHD2
Domain Architecture
Description	EH-domain-containing protein 2.

EHD3_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.051475 (rank : 280)
Query Neighborhood Hits	228	Target Neighborhood Hits	33	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZN3, Q8N514, Q9NZB3	Gene names	EHD3, EHD2
Domain Architecture
Description	EH-domain-containing protein 3.

EHD3_MOUSE
θ value	θ > 10 (rank : 260)	NC score	0.051069 (rank : 285)
Query Neighborhood Hits	228	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QXY6	Gene names	Ehd3, Ehd2
Domain Architecture
Description	EH-domain-containing protein 3.

EHD4_MOUSE
θ value	θ > 10 (rank : 261)	NC score	0.050884 (rank : 286)
Query Neighborhood Hits	228	Target Neighborhood Hits	40	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EQP2	Gene names	Ehd4, Past2
Domain Architecture
Description	EH-domain-containing protein 4 (mPAST2).

EP15R_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.051817 (rank : 275)
Query Neighborhood Hits	228	Target Neighborhood Hits	1083	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

EP15R_MOUSE
θ value	θ > 10 (rank : 263)	NC score	0.053965 (rank : 263)
Query Neighborhood Hits	228	Target Neighborhood Hits	1135	Shared Neighborhood Hits	32
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

EP15_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.053463 (rank : 268)
Query Neighborhood Hits	228	Target Neighborhood Hits	1021	Shared Neighborhood Hits	37
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP15_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.053266 (rank : 270)
Query Neighborhood Hits	228	Target Neighborhood Hits	820	Shared Neighborhood Hits	26
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EPS8_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.051819 (rank : 274)
Query Neighborhood Hits	228	Target Neighborhood Hits	151	Shared Neighborhood Hits	47
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.055011 (rank : 261)
Query Neighborhood Hits	228	Target Neighborhood Hits	157	Shared Neighborhood Hits	50
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L1_MOUSE
θ value	θ > 10 (rank : 268)	NC score	0.052891 (rank : 271)
Query Neighborhood Hits	228	Target Neighborhood Hits	143	Shared Neighborhood Hits	35
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L2_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.058217 (rank : 254)
Query Neighborhood Hits	228	Target Neighborhood Hits	193	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_MOUSE
θ value	θ > 10 (rank : 270)	NC score	0.061405 (rank : 245)
Query Neighborhood Hits	228	Target Neighborhood Hits	169	Shared Neighborhood Hits	54
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L3_HUMAN
θ value	θ > 10 (rank : 271)	NC score	0.064425 (rank : 234)
Query Neighborhood Hits	228	Target Neighborhood Hits	206	Shared Neighborhood Hits	48
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L3_MOUSE
θ value	θ > 10 (rank : 272)	NC score	0.070423 (rank : 225)
Query Neighborhood Hits	228	Target Neighborhood Hits	168	Shared Neighborhood Hits	57
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FGD5_HUMAN
θ value	θ > 10 (rank : 273)	NC score	0.381555 (rank : 64)
Query Neighborhood Hits	228	Target Neighborhood Hits	235	Shared Neighborhood Hits	51
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FNBP2_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.080936 (rank : 209)
Query Neighborhood Hits	228	Target Neighborhood Hits	432	Shared Neighborhood Hits	78
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

FYV1_HUMAN
θ value	θ > 10 (rank : 275)	NC score	0.061486 (rank : 244)
Query Neighborhood Hits	228	Target Neighborhood Hits	217	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	θ > 10 (rank : 276)	NC score	0.060550 (rank : 250)
Query Neighborhood Hits	228	Target Neighborhood Hits	191	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

GRAP2_HUMAN
θ value	θ > 10 (rank : 277)	NC score	0.149915 (rank : 138)
Query Neighborhood Hits	228	Target Neighborhood Hits	304	Shared Neighborhood Hits	78
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 278)	NC score	0.150448 (rank : 137)
Query Neighborhood Hits	228	Target Neighborhood Hits	297	Shared Neighborhood Hits	78
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRB2_HUMAN
θ value	θ > 10 (rank : 279)	NC score	0.165536 (rank : 113)
Query Neighborhood Hits	228	Target Neighborhood Hits	310	Shared Neighborhood Hits	81
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 280)	NC score	0.165437 (rank : 114)
Query Neighborhood Hits	228	Target Neighborhood Hits	312	Shared Neighborhood Hits	81
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRP3_HUMAN
θ value	θ > 10 (rank : 281)	NC score	0.076324 (rank : 217)
Query Neighborhood Hits	228	Target Neighborhood Hits	131	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

HCLS1_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.160500 (rank : 125)
Query Neighborhood Hits	228	Target Neighborhood Hits	358	Shared Neighborhood Hits	84
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.163573 (rank : 118)
Query Neighborhood Hits	228	Target Neighborhood Hits	329	Shared Neighborhood Hits	87
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HGS_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.088983 (rank : 197)
Query Neighborhood Hits	228	Target Neighborhood Hits	517	Shared Neighborhood Hits	29
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.090333 (rank : 194)
Query Neighborhood Hits	228	Target Neighborhood Hits	589	Shared Neighborhood Hits	32
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

IASPP_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.081223 (rank : 208)
Query Neighborhood Hits	228	Target Neighborhood Hits	688	Shared Neighborhood Hits	80
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IASPP_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.079563 (rank : 212)
Query Neighborhood Hits	228	Target Neighborhood Hits	1024	Shared Neighborhood Hits	91
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

LBC_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.537726 (rank : 37)
Query Neighborhood Hits	228	Target Neighborhood Hits	90	Shared Neighborhood Hits	57
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

MIA_HUMAN
θ value	θ > 10 (rank : 289)	NC score	0.051248 (rank : 283)
Query Neighborhood Hits	228	Target Neighborhood Hits	19	Shared Neighborhood Hits	11
SwissProt Accessions	Q16674	Gene names	MIA
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity).

MIA_MOUSE
θ value	θ > 10 (rank : 290)	NC score	0.050374 (rank : 289)
Query Neighborhood Hits	228	Target Neighborhood Hits	17	Shared Neighborhood Hits	9
SwissProt Accessions	Q61865, O09086, P97495	Gene names	Mia, Cdrap, Mia1
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity) (Cartilage-derived retinoic acid-sensitive protein) (CD-RAP).

NCF4_HUMAN
θ value	θ > 10 (rank : 291)	NC score	0.169672 (rank : 108)
Query Neighborhood Hits	228	Target Neighborhood Hits	161	Shared Neighborhood Hits	65
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 292)	NC score	0.179478 (rank : 102)
Query Neighborhood Hits	228	Target Neighborhood Hits	177	Shared Neighborhood Hits	73
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NOXO1_HUMAN
θ value	θ > 10 (rank : 293)	NC score	0.125195 (rank : 160)
Query Neighborhood Hits	228	Target Neighborhood Hits	100	Shared Neighborhood Hits	47
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

OBSCN_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.060583 (rank : 249)
Query Neighborhood Hits	228	Target Neighborhood Hits	1931	Shared Neighborhood Hits	91
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

OSTF1_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.129361 (rank : 156)
Query Neighborhood Hits	228	Target Neighborhood Hits	466	Shared Neighborhood Hits	84
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 296)	NC score	0.126090 (rank : 159)
Query Neighborhood Hits	228	Target Neighborhood Hits	467	Shared Neighborhood Hits	84
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

P85A_HUMAN
θ value	θ > 10 (rank : 297)	NC score	0.083014 (rank : 203)
Query Neighborhood Hits	228	Target Neighborhood Hits	479	Shared Neighborhood Hits	70
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 298)	NC score	0.082732 (rank : 205)
Query Neighborhood Hits	228	Target Neighborhood Hits	435	Shared Neighborhood Hits	70
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.069926 (rank : 226)
Query Neighborhood Hits	228	Target Neighborhood Hits	543	Shared Neighborhood Hits	52
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 300)	NC score	0.065670 (rank : 232)
Query Neighborhood Hits	228	Target Neighborhood Hits	519	Shared Neighborhood Hits	50
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PEX13_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.090034 (rank : 196)
Query Neighborhood Hits	228	Target Neighborhood Hits	128	Shared Neighborhood Hits	49
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 302)	NC score	0.095973 (rank : 188)
Query Neighborhood Hits	228	Target Neighborhood Hits	126	Shared Neighborhood Hits	56
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PKHA6_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.064205 (rank : 235)
Query Neighborhood Hits	228	Target Neighborhood Hits	556	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	θ > 10 (rank : 304)	NC score	0.067148 (rank : 229)
Query Neighborhood Hits	228	Target Neighborhood Hits	591	Shared Neighborhood Hits	36
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHF1_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.162348 (rank : 120)
Query Neighborhood Hits	228	Target Neighborhood Hits	76	Shared Neighborhood Hits	17
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
θ value	θ > 10 (rank : 306)	NC score	0.161456 (rank : 123)
Query Neighborhood Hits	228	Target Neighborhood Hits	80	Shared Neighborhood Hits	16
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF2_HUMAN
θ value	θ > 10 (rank : 307)	NC score	0.174281 (rank : 105)
Query Neighborhood Hits	228	Target Neighborhood Hits	75	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	θ > 10 (rank : 308)	NC score	0.173696 (rank : 106)
Query Neighborhood Hits	228	Target Neighborhood Hits	77	Shared Neighborhood Hits	17
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHG4_HUMAN
θ value	θ > 10 (rank : 309)	NC score	0.311213 (rank : 70)
Query Neighborhood Hits	228	Target Neighborhood Hits	200	Shared Neighborhood Hits	55
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

PLCG2_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.141264 (rank : 145)
Query Neighborhood Hits	228	Target Neighborhood Hits	280	Shared Neighborhood Hits	70
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP2_HUMAN
θ value	θ > 10 (rank : 311)	NC score	0.055962 (rank : 258)
Query Neighborhood Hits	228	Target Neighborhood Hits	254	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PPIP2_MOUSE
θ value	θ > 10 (rank : 312)	NC score	0.051628 (rank : 278)
Query Neighborhood Hits	228	Target Neighborhood Hits	308	Shared Neighborhood Hits	22
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

RBNS5_HUMAN
θ value	θ > 10 (rank : 313)	NC score	0.092965 (rank : 192)
Query Neighborhood Hits	228	Target Neighborhood Hits	242	Shared Neighborhood Hits	23
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	θ > 10 (rank : 314)	NC score	0.080484 (rank : 210)
Query Neighborhood Hits	228	Target Neighborhood Hits	266	Shared Neighborhood Hits	17
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

REPS1_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.066699 (rank : 230)
Query Neighborhood Hits	228	Target Neighborhood Hits	205	Shared Neighborhood Hits	14
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS1_MOUSE
θ value	θ > 10 (rank : 316)	NC score	0.072714 (rank : 222)
Query Neighborhood Hits	228	Target Neighborhood Hits	204	Shared Neighborhood Hits	15
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS2_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.079137 (rank : 213)
Query Neighborhood Hits	228	Target Neighborhood Hits	131	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_MOUSE
θ value	θ > 10 (rank : 318)	NC score	0.077025 (rank : 216)
Query Neighborhood Hits	228	Target Neighborhood Hits	102	Shared Neighborhood Hits	8
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

RHG04_HUMAN
θ value	θ > 10 (rank : 319)	NC score	0.102086 (rank : 175)
Query Neighborhood Hits	228	Target Neighborhood Hits	307	Shared Neighborhood Hits	75
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RHG26_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.083023 (rank : 202)
Query Neighborhood Hits	228	Target Neighborhood Hits	281	Shared Neighborhood Hits	73
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RIMB1_HUMAN
θ value	θ > 10 (rank : 321)	NC score	0.062495 (rank : 241)
Query Neighborhood Hits	228	Target Neighborhood Hits	1479	Shared Neighborhood Hits	100
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB1_MOUSE
θ value	θ > 10 (rank : 322)	NC score	0.055889 (rank : 259)
Query Neighborhood Hits	228	Target Neighborhood Hits	1376	Shared Neighborhood Hits	98
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB2_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.097087 (rank : 187)
Query Neighborhood Hits	228	Target Neighborhood Hits	263	Shared Neighborhood Hits	61
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 324)	NC score	0.100029 (rank : 179)
Query Neighborhood Hits	228	Target Neighborhood Hits	246	Shared Neighborhood Hits	58
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RPGF1_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.057571 (rank : 255)
Query Neighborhood Hits	228	Target Neighborhood Hits	262	Shared Neighborhood Hits	21
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

RUFY1_HUMAN
θ value	θ > 10 (rank : 326)	NC score	0.062366 (rank : 243)
Query Neighborhood Hits	228	Target Neighborhood Hits	848	Shared Neighborhood Hits	38
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

RUFY1_MOUSE
θ value	θ > 10 (rank : 327)	NC score	0.062771 (rank : 240)
Query Neighborhood Hits	228	Target Neighborhood Hits	765	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY2_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.063932 (rank : 236)
Query Neighborhood Hits	228	Target Neighborhood Hits	1208	Shared Neighborhood Hits	44
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

RUFY2_MOUSE
θ value	θ > 10 (rank : 329)	NC score	0.063618 (rank : 238)
Query Neighborhood Hits	228	Target Neighborhood Hits	820	Shared Neighborhood Hits	30
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

RUSC1_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.078913 (rank : 214)
Query Neighborhood Hits	228	Target Neighborhood Hits	226	Shared Neighborhood Hits	56
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

RUSC1_MOUSE
θ value	θ > 10 (rank : 331)	NC score	0.072040 (rank : 223)
Query Neighborhood Hits	228	Target Neighborhood Hits	206	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

SH3G1_MOUSE
θ value	θ > 10 (rank : 332)	NC score	0.139366 (rank : 148)
Query Neighborhood Hits	228	Target Neighborhood Hits	291	Shared Neighborhood Hits	83
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 333)	NC score	0.143731 (rank : 143)
Query Neighborhood Hits	228	Target Neighborhood Hits	324	Shared Neighborhood Hits	86
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 334)	NC score	0.143936 (rank : 142)
Query Neighborhood Hits	228	Target Neighborhood Hits	319	Shared Neighborhood Hits	87
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.146373 (rank : 140)
Query Neighborhood Hits	228	Target Neighborhood Hits	222	Shared Neighborhood Hits	79
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 336)	NC score	0.150691 (rank : 136)
Query Neighborhood Hits	228	Target Neighborhood Hits	236	Shared Neighborhood Hits	78
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SHLB1_HUMAN
θ value	θ > 10 (rank : 337)	NC score	0.064745 (rank : 233)
Query Neighborhood Hits	228	Target Neighborhood Hits	96	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB1_MOUSE
θ value	θ > 10 (rank : 338)	NC score	0.061394 (rank : 246)
Query Neighborhood Hits	228	Target Neighborhood Hits	101	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SHLB2_HUMAN
θ value	θ > 10 (rank : 339)	NC score	0.062410 (rank : 242)
Query Neighborhood Hits	228	Target Neighborhood Hits	86	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	θ > 10 (rank : 340)	NC score	0.062772 (rank : 239)
Query Neighborhood Hits	228	Target Neighborhood Hits	88	Shared Neighborhood Hits	32
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SLY_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.051267 (rank : 282)
Query Neighborhood Hits	228	Target Neighborhood Hits	81	Shared Neighborhood Hits	35
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SLY_MOUSE
θ value	θ > 10 (rank : 342)	NC score	0.058517 (rank : 253)
Query Neighborhood Hits	228	Target Neighborhood Hits	108	Shared Neighborhood Hits	40
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SNX18_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.099355 (rank : 182)
Query Neighborhood Hits	228	Target Neighborhood Hits	207	Shared Neighborhood Hits	64
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_MOUSE
θ value	θ > 10 (rank : 344)	NC score	0.101229 (rank : 177)
Query Neighborhood Hits	228	Target Neighborhood Hits	198	Shared Neighborhood Hits	63
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX9_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.083223 (rank : 201)
Query Neighborhood Hits	228	Target Neighborhood Hits	148	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SNX9_MOUSE
θ value	θ > 10 (rank : 346)	NC score	0.060675 (rank : 248)
Query Neighborhood Hits	228	Target Neighborhood Hits	141	Shared Neighborhood Hits	46
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SOS2_HUMAN
θ value	θ > 10 (rank : 347)	NC score	0.213226 (rank : 90)
Query Neighborhood Hits	228	Target Neighborhood Hits	193	Shared Neighborhood Hits	41
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SPN90_HUMAN
θ value	θ > 10 (rank : 348)	NC score	0.050139 (rank : 291)
Query Neighborhood Hits	228	Target Neighborhood Hits	157	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPTA1_HUMAN
θ value	θ > 10 (rank : 349)	NC score	0.063738 (rank : 237)
Query Neighborhood Hits	228	Target Neighborhood Hits	748	Shared Neighborhood Hits	81
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA1_MOUSE
θ value	θ > 10 (rank : 350)	NC score	0.066103 (rank : 231)
Query Neighborhood Hits	228	Target Neighborhood Hits	675	Shared Neighborhood Hits	73
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
θ value	θ > 10 (rank : 351)	NC score	0.074763 (rank : 220)
Query Neighborhood Hits	228	Target Neighborhood Hits	888	Shared Neighborhood Hits	90
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SRC8_HUMAN
θ value	θ > 10 (rank : 352)	NC score	0.164268 (rank : 117)
Query Neighborhood Hits	228	Target Neighborhood Hits	269	Shared Neighborhood Hits	82
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 353)	NC score	0.164278 (rank : 116)
Query Neighborhood Hits	228	Target Neighborhood Hits	292	Shared Neighborhood Hits	83
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRGP1_HUMAN
θ value	θ > 10 (rank : 354)	NC score	0.081850 (rank : 206)
Query Neighborhood Hits	228	Target Neighborhood Hits	390	Shared Neighborhood Hits	77
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
θ value	θ > 10 (rank : 355)	NC score	0.081677 (rank : 207)
Query Neighborhood Hits	228	Target Neighborhood Hits	331	Shared Neighborhood Hits	79
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
θ value	θ > 10 (rank : 356)	NC score	0.082784 (rank : 204)
Query Neighborhood Hits	228	Target Neighborhood Hits	324	Shared Neighborhood Hits	76
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

STAC3_HUMAN
θ value	θ > 10 (rank : 357)	NC score	0.138358 (rank : 150)
Query Neighborhood Hits	228	Target Neighborhood Hits	228	Shared Neighborhood Hits	72
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 358)	NC score	0.139884 (rank : 147)
Query Neighborhood Hits	228	Target Neighborhood Hits	232	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 359)	NC score	0.163076 (rank : 119)
Query Neighborhood Hits	228	Target Neighborhood Hits	276	Shared Neighborhood Hits	86
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 360)	NC score	0.158282 (rank : 126)
Query Neighborhood Hits	228	Target Neighborhood Hits	268	Shared Neighborhood Hits	86
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 361)	NC score	0.165871 (rank : 110)
Query Neighborhood Hits	228	Target Neighborhood Hits	271	Shared Neighborhood Hits	79
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 362)	NC score	0.165773 (rank : 111)
Query Neighborhood Hits	228	Target Neighborhood Hits	273	Shared Neighborhood Hits	78
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STS2_HUMAN
θ value	θ > 10 (rank : 363)	NC score	0.105846 (rank : 171)
Query Neighborhood Hits	228	Target Neighborhood Hits	108	Shared Neighborhood Hits	54
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

WDFY1_HUMAN
θ value	θ > 10 (rank : 364)	NC score	0.056898 (rank : 257)
Query Neighborhood Hits	228	Target Neighborhood Hits	305	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

WDFY3_HUMAN
θ value	θ > 10 (rank : 365)	NC score	0.054702 (rank : 262)
Query Neighborhood Hits	228	Target Neighborhood Hits	348	Shared Neighborhood Hits	17
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY3_MOUSE
θ value	θ > 10 (rank : 366)	NC score	0.053500 (rank : 267)
Query Neighborhood Hits	228	Target Neighborhood Hits	332	Shared Neighborhood Hits	12
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

ZFY16_HUMAN
θ value	θ > 10 (rank : 367)	NC score	0.099775 (rank : 180)
Query Neighborhood Hits	228	Target Neighborhood Hits	125	Shared Neighborhood Hits	14
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY16_MOUSE
θ value	θ > 10 (rank : 368)	NC score	0.102121 (rank : 174)
Query Neighborhood Hits	228	Target Neighborhood Hits	108	Shared Neighborhood Hits	11
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY19_HUMAN
θ value	θ > 10 (rank : 369)	NC score	0.071387 (rank : 224)
Query Neighborhood Hits	228	Target Neighborhood Hits	206	Shared Neighborhood Hits	12
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ZFY19_MOUSE
θ value	θ > 10 (rank : 370)	NC score	0.068855 (rank : 227)
Query Neighborhood Hits	228	Target Neighborhood Hits	143	Shared Neighborhood Hits	13
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

ZFY21_HUMAN
θ value	θ > 10 (rank : 371)	NC score	0.095902 (rank : 189)
Query Neighborhood Hits	228	Target Neighborhood Hits	72	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_MOUSE
θ value	θ > 10 (rank : 372)	NC score	0.098970 (rank : 183)
Query Neighborhood Hits	228	Target Neighborhood Hits	72	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY28_HUMAN
θ value	θ > 10 (rank : 373)	NC score	0.110565 (rank : 168)
Query Neighborhood Hits	228	Target Neighborhood Hits	152	Shared Neighborhood Hits	13
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV1_HUMAN
θ value	θ > 10 (rank : 374)	NC score	0.060948 (rank : 247)
Query Neighborhood Hits	228	Target Neighborhood Hits	166	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
θ value	θ > 10 (rank : 375)	NC score	0.059864 (rank : 251)
Query Neighborhood Hits	228	Target Neighborhood Hits	153	Shared Neighborhood Hits	11
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

ZFYV9_HUMAN
θ value	θ > 10 (rank : 376)	NC score	0.108068 (rank : 169)
Query Neighborhood Hits	228	Target Neighborhood Hits	134	Shared Neighborhood Hits	12
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

Hits sorted by NC score

NGEF_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	228	Target Neighborhood Hits	228	Shared Neighborhood Hits	228
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_HUMAN
NC score	0.982959 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	228	Target Neighborhood Hits	166	Shared Neighborhood Hits	139
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHG5_HUMAN
NC score	0.920911 (rank : 3)	θ value	4.05562e-101 (rank : 3)
Query Neighborhood Hits	228	Target Neighborhood Hits	172	Shared Neighborhood Hits	115
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHGG_HUMAN
NC score	0.915839 (rank : 4)	θ value	3.93732e-88 (rank : 5)
Query Neighborhood Hits	228	Target Neighborhood Hits	129	Shared Neighborhood Hits	97
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
NC score	0.914799 (rank : 5)	θ value	1.03614e-88 (rank : 4)
Query Neighborhood Hits	228	Target Neighborhood Hits	152	Shared Neighborhood Hits	108
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGF_HUMAN
NC score	0.864390 (rank : 6)	θ value	5.69867e-79 (rank : 6)
Query Neighborhood Hits	228	Target Neighborhood Hits	214	Shared Neighborhood Hits	73
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ECT2_MOUSE
NC score	0.665085 (rank : 7)	θ value	5.08577e-11 (rank : 31)
Query Neighborhood Hits	228	Target Neighborhood Hits	98	Shared Neighborhood Hits	70
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_HUMAN
NC score	0.655921 (rank : 8)	θ value	2.98157e-11 (rank : 30)
Query Neighborhood Hits	228	Target Neighborhood Hits	98	Shared Neighborhood Hits	70
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHG1_HUMAN
NC score	0.651711 (rank : 9)	θ value	3.18553e-13 (rank : 25)
Query Neighborhood Hits	228	Target Neighborhood Hits	176	Shared Neighborhood Hits	62
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

FGD4_HUMAN
NC score	0.644496 (rank : 10)	θ value	2.27762e-19 (rank : 12)
Query Neighborhood Hits	228	Target Neighborhood Hits	219	Shared Neighborhood Hits	71
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
NC score	0.643770 (rank : 11)	θ value	1.02238e-19 (rank : 11)
Query Neighborhood Hits	228	Target Neighborhood Hits	227	Shared Neighborhood Hits	70
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD3_MOUSE
NC score	0.640051 (rank : 12)	θ value	1.52774e-15 (rank : 18)
Query Neighborhood Hits	228	Target Neighborhood Hits	257	Shared Neighborhood Hits	72
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

ARHG8_HUMAN
NC score	0.630984 (rank : 13)	θ value	3.29651e-10 (rank : 37)
Query Neighborhood Hits	228	Target Neighborhood Hits	85	Shared Neighborhood Hits	65
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG1_MOUSE
NC score	0.630160 (rank : 14)	θ value	1.2105e-12 (rank : 26)
Query Neighborhood Hits	228	Target Neighborhood Hits	266	Shared Neighborhood Hits	61
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

FGD2_HUMAN
NC score	0.627051 (rank : 15)	θ value	1.99529e-15 (rank : 19)
Query Neighborhood Hits	228	Target Neighborhood Hits	151	Shared Neighborhood Hits	69
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

PREX1_HUMAN
NC score	0.626334 (rank : 16)	θ value	1.58096e-12 (rank : 27)
Query Neighborhood Hits	228	Target Neighborhood Hits	177	Shared Neighborhood Hits	71
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

FGD2_MOUSE
NC score	0.626306 (rank : 17)	θ value	9.90251e-15 (rank : 20)
Query Neighborhood Hits	228	Target Neighborhood Hits	163	Shared Neighborhood Hits	69
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
NC score	0.625222 (rank : 18)	θ value	1.52774e-15 (rank : 17)
Query Neighborhood Hits	228	Target Neighborhood Hits	249	Shared Neighborhood Hits	69
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

ARHGB_HUMAN
NC score	0.624691 (rank : 19)	θ value	2.88119e-14 (rank : 23)
Query Neighborhood Hits	228	Target Neighborhood Hits	375	Shared Neighborhood Hits	77
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

FGD1_HUMAN
NC score	0.623099 (rank : 20)	θ value	1.13037e-18 (rank : 14)
Query Neighborhood Hits	228	Target Neighborhood Hits	367	Shared Neighborhood Hits	76
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
NC score	0.622706 (rank : 21)	θ value	5.07402e-19 (rank : 13)
Query Neighborhood Hits	228	Target Neighborhood Hits	387	Shared Neighborhood Hits	75
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ARHG3_HUMAN
NC score	0.622337 (rank : 22)	θ value	2.61198e-07 (rank : 44)
Query Neighborhood Hits	228	Target Neighborhood Hits	82	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.620997 (rank : 23)	θ value	1.53129e-07 (rank : 43)
Query Neighborhood Hits	228	Target Neighborhood Hits	85	Shared Neighborhood Hits	63
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG4_HUMAN
NC score	0.609800 (rank : 24)	θ value	7.59969e-07 (rank : 48)
Query Neighborhood Hits	228	Target Neighborhood Hits	242	Shared Neighborhood Hits	123
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHGC_MOUSE
NC score	0.609724 (rank : 25)	θ value	2.13179e-17 (rank : 15)
Query Neighborhood Hits	228	Target Neighborhood Hits	344	Shared Neighborhood Hits	69
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_HUMAN
NC score	0.608032 (rank : 26)	θ value	3.07829e-16 (rank : 16)
Query Neighborhood Hits	228	Target Neighborhood Hits	351	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHG4_MOUSE
NC score	0.606820 (rank : 27)	θ value	1.69304e-06 (rank : 50)
Query Neighborhood Hits	228	Target Neighborhood Hits	185	Shared Neighborhood Hits	99
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG8_MOUSE
NC score	0.604171 (rank : 28)	θ value	1.25267e-09 (rank : 38)
Query Neighborhood Hits	228	Target Neighborhood Hits	79	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

PKHG1_HUMAN
NC score	0.598989 (rank : 29)	θ value	1.133e-10 (rank : 35)
Query Neighborhood Hits	228	Target Neighborhood Hits	174	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHG2_MOUSE
NC score	0.596046 (rank : 30)	θ value	7.59969e-07 (rank : 47)
Query Neighborhood Hits	228	Target Neighborhood Hits	120	Shared Neighborhood Hits	61
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG9_HUMAN
NC score	0.590019 (rank : 31)	θ value	4.92598e-06 (rank : 52)
Query Neighborhood Hits	228	Target Neighborhood Hits	235	Shared Neighborhood Hits	118
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.589961 (rank : 32)	θ value	2.88788e-06 (rank : 51)
Query Neighborhood Hits	228	Target Neighborhood Hits	234	Shared Neighborhood Hits	116
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG2_HUMAN
NC score	0.574491 (rank : 33)	θ value	8.97725e-08 (rank : 41)
Query Neighborhood Hits	228	Target Neighborhood Hits	142	Shared Neighborhood Hits	61
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

TIAM1_MOUSE
NC score	0.568599 (rank : 34)	θ value	7.59969e-07 (rank : 49)
Query Neighborhood Hits	228	Target Neighborhood Hits	205	Shared Neighborhood Hits	69
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_HUMAN
NC score	0.561117 (rank : 35)	θ value	4.45536e-07 (rank : 46)
Query Neighborhood Hits	228	Target Neighborhood Hits	225	Shared Neighborhood Hits	73
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

FGD6_MOUSE
NC score	0.541732 (rank : 36)	θ value	5.08577e-11 (rank : 32)
Query Neighborhood Hits	228	Target Neighborhood Hits	282	Shared Neighborhood Hits	71
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

LBC_HUMAN
NC score	0.537726 (rank : 37)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	228	Target Neighborhood Hits	90	Shared Neighborhood Hits	57
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

FGD6_HUMAN
NC score	0.536746 (rank : 38)	θ value	8.67504e-11 (rank : 34)
Query Neighborhood Hits	228	Target Neighborhood Hits	237	Shared Neighborhood Hits	62
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

ITSN2_HUMAN
NC score	0.534647 (rank : 39)	θ value	5.79196e-23 (rank : 9)
Query Neighborhood Hits	228	Target Neighborhood Hits	1173	Shared Neighborhood Hits	154
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

VAV2_HUMAN
NC score	0.531947 (rank : 40)	θ value	1.29331e-14 (rank : 22)
Query Neighborhood Hits	228	Target Neighborhood Hits	453	Shared Neighborhood Hits	128
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
NC score	0.527653 (rank : 41)	θ value	9.90251e-15 (rank : 21)
Query Neighborhood Hits	228	Target Neighborhood Hits	456	Shared Neighborhood Hits	128
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV_MOUSE
NC score	0.521583 (rank : 42)	θ value	5.08577e-11 (rank : 33)
Query Neighborhood Hits	228	Target Neighborhood Hits	430	Shared Neighborhood Hits	133
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV_HUMAN
NC score	0.511026 (rank : 43)	θ value	1.33837e-11 (rank : 29)
Query Neighborhood Hits	228	Target Neighborhood Hits	452	Shared Neighborhood Hits	130
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

GNRP_MOUSE
NC score	0.510848 (rank : 44)	θ value	1.86753e-13 (rank : 24)
Query Neighborhood Hits	228	Target Neighborhood Hits	191	Shared Neighborhood Hits	63
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ITSN2_MOUSE
NC score	0.506476 (rank : 45)	θ value	1.86321e-21 (rank : 10)
Query Neighborhood Hits	228	Target Neighborhood Hits	1371	Shared Neighborhood Hits	158
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

RGNEF_MOUSE
NC score	0.505699 (rank : 46)	θ value	2.79066e-09 (rank : 39)
Query Neighborhood Hits	228	Target Neighborhood Hits	641	Shared Neighborhood Hits	80
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ARHGA_HUMAN
NC score	0.503545 (rank : 47)	θ value	8.97725e-08 (rank : 42)
Query Neighborhood Hits	228	Target Neighborhood Hits	187	Shared Neighborhood Hits	69
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

DNMBP_MOUSE
NC score	0.500154 (rank : 48)	θ value	0.00020696 (rank : 61)
Query Neighborhood Hits	228	Target Neighborhood Hits	435	Shared Neighborhood Hits	137
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ITSN1_MOUSE
NC score	0.498777 (rank : 49)	θ value	6.84181e-24 (rank : 8)
Query Neighborhood Hits	228	Target Neighborhood Hits	1669	Shared Neighborhood Hits	169
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN1_HUMAN
NC score	0.498074 (rank : 50)	θ value	3.07116e-24 (rank : 7)
Query Neighborhood Hits	228	Target Neighborhood Hits	1757	Shared Neighborhood Hits	176
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

MCF2_HUMAN
NC score	0.485259 (rank : 51)	θ value	9.29e-05 (rank : 58)
Query Neighborhood Hits	228	Target Neighborhood Hits	166	Shared Neighborhood Hits	68
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

GNRP_HUMAN
NC score	0.481068 (rank : 52)	θ value	3.52202e-12 (rank : 28)
Query Neighborhood Hits	228	Target Neighborhood Hits	239	Shared Neighborhood Hits	59
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

DNMBP_HUMAN
NC score	0.472795 (rank : 53)	θ value	0.0252991 (rank : 86)
Query Neighborhood Hits	228	Target Neighborhood Hits	413	Shared Neighborhood Hits	137
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHGA_MOUSE
NC score	0.470092 (rank : 54)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	228	Target Neighborhood Hits	125	Shared Neighborhood Hits	64
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

VAV3_MOUSE
NC score	0.468033 (rank : 55)	θ value	1.09739e-05 (rank : 54)
Query Neighborhood Hits	228	Target Neighborhood Hits	404	Shared Neighborhood Hits	130
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

MCF2L_MOUSE
NC score	0.467313 (rank : 56)	θ value	0.00035302 (rank : 65)
Query Neighborhood Hits	228	Target Neighborhood Hits	255	Shared Neighborhood Hits	75
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

VAV3_HUMAN
NC score	0.464017 (rank : 57)	θ value	4.1701e-05 (rank : 56)
Query Neighborhood Hits	228	Target Neighborhood Hits	398	Shared Neighborhood Hits	127
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ARHG7_MOUSE
NC score	0.428080 (rank : 58)	θ value	0.0961366 (rank : 96)
Query Neighborhood Hits	228	Target Neighborhood Hits	396	Shared Neighborhood Hits	125
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG7_HUMAN
NC score	0.426467 (rank : 59)	θ value	2.36792 (rank : 159)
Query Neighborhood Hits	228	Target Neighborhood Hits	347	Shared Neighborhood Hits	130
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

FARP2_MOUSE
NC score	0.424657 (rank : 60)	θ value	1.47974e-10 (rank : 36)
Query Neighborhood Hits	228	Target Neighborhood Hits	209	Shared Neighborhood Hits	70
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

HAPIP_HUMAN
NC score	0.400170 (rank : 61)	θ value	2.44474e-05 (rank : 55)
Query Neighborhood Hits	228	Target Neighborhood Hits	350	Shared Neighborhood Hits	72
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

FARP2_HUMAN
NC score	0.389207 (rank : 62)	θ value	5.26297e-08 (rank : 40)
Query Neighborhood Hits	228	Target Neighborhood Hits	240	Shared Neighborhood Hits	65
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ARHG6_HUMAN
NC score	0.388556 (rank : 63)	θ value	6.88961 (rank : 202)
Query Neighborhood Hits	228	Target Neighborhood Hits	376	Shared Neighborhood Hits	124
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

FGD5_HUMAN
NC score	0.381555 (rank : 64)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	228	Target Neighborhood Hits	235	Shared Neighborhood Hits	51
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

ARHG6_MOUSE
NC score	0.370608 (rank : 65)	θ value	5.27518 (rank : 189)
Query Neighborhood Hits	228	Target Neighborhood Hits	394	Shared Neighborhood Hits	122
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

FGD5_MOUSE
NC score	0.370044 (rank : 66)	θ value	4.03905 (rank : 181)
Query Neighborhood Hits	228	Target Neighborhood Hits	170	Shared Neighborhood Hits	49
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FARP1_HUMAN
NC score	0.368505 (rank : 67)	θ value	2.61198e-07 (rank : 45)
Query Neighborhood Hits	228	Target Neighborhood Hits	241	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

BCR_HUMAN
NC score	0.322927 (rank : 68)	θ value	0.0961366 (rank : 97)
Query Neighborhood Hits	228	Target Neighborhood Hits	204	Shared Neighborhood Hits	65
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ABR_HUMAN
NC score	0.314808 (rank : 69)	θ value	0.365318 (rank : 116)
Query Neighborhood Hits	228	Target Neighborhood Hits	166	Shared Neighborhood Hits	64
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

PKHG4_HUMAN
NC score	0.311213 (rank : 70)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	228	Target Neighborhood Hits	200	Shared Neighborhood Hits	55
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

SRBS1_MOUSE
NC score	0.287354 (rank : 71)	θ value	5.44631e-05 (rank : 57)
Query Neighborhood Hits	228	Target Neighborhood Hits	409	Shared Neighborhood Hits	102
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SH3K1_HUMAN
NC score	0.279953 (rank : 72)	θ value	0.0252991 (rank : 87)
Query Neighborhood Hits	228	Target Neighborhood Hits	341	Shared Neighborhood Hits	94
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SRBS1_HUMAN
NC score	0.278456 (rank : 73)	θ value	0.000270298 (rank : 64)
Query Neighborhood Hits	228	Target Neighborhood Hits	396	Shared Neighborhood Hits	107
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

CD2AP_HUMAN
NC score	0.276984 (rank : 74)	θ value	0.00102713 (rank : 68)
Query Neighborhood Hits	228	Target Neighborhood Hits	315	Shared Neighborhood Hits	93
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
NC score	0.274635 (rank : 75)	θ value	0.00390308 (rank : 74)
Query Neighborhood Hits	228	Target Neighborhood Hits	336	Shared Neighborhood Hits	94
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

NCF1_MOUSE
NC score	0.274568 (rank : 76)	θ value	0.000602161 (rank : 66)
Query Neighborhood Hits	228	Target Neighborhood Hits	198	Shared Neighborhood Hits	79
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

SH3K1_MOUSE
NC score	0.271440 (rank : 77)	θ value	0.0252991 (rank : 88)
Query Neighborhood Hits	228	Target Neighborhood Hits	332	Shared Neighborhood Hits	95
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

NCF1_HUMAN
NC score	0.271301 (rank : 78)	θ value	0.00390308 (rank : 76)
Query Neighborhood Hits	228	Target Neighborhood Hits	198	Shared Neighborhood Hits	77
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

VINEX_HUMAN
NC score	0.254181 (rank : 79)	θ value	0.0961366 (rank : 99)
Query Neighborhood Hits	228	Target Neighborhood Hits	270	Shared Neighborhood Hits	95
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

NCF2_HUMAN
NC score	0.253968 (rank : 80)	θ value	0.163984 (rank : 103)
Query Neighborhood Hits	228	Target Neighborhood Hits	229	Shared Neighborhood Hits	85
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

VINEX_MOUSE
NC score	0.248862 (rank : 81)	θ value	0.0961366 (rank : 100)
Query Neighborhood Hits	228	Target Neighborhood Hits	286	Shared Neighborhood Hits	94
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

SOS1_HUMAN
NC score	0.241684 (rank : 82)	θ value	0.000121331 (rank : 59)
Query Neighborhood Hits	228	Target Neighborhood Hits	274	Shared Neighborhood Hits	42
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

PPIP1_HUMAN
NC score	0.225393 (rank : 83)	θ value	0.00020696 (rank : 62)
Query Neighborhood Hits	228	Target Neighborhood Hits	389	Shared Neighborhood Hits	94
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

NCK2_HUMAN
NC score	0.223176 (rank : 84)	θ value	0.00869519 (rank : 80)
Query Neighborhood Hits	228	Target Neighborhood Hits	310	Shared Neighborhood Hits	86
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NCK1_HUMAN
NC score	0.222881 (rank : 85)	θ value	0.0330416 (rank : 89)
Query Neighborhood Hits	228	Target Neighborhood Hits	312	Shared Neighborhood Hits	90
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SOS1_MOUSE
NC score	0.220609 (rank : 86)	θ value	0.0330416 (rank : 90)
Query Neighborhood Hits	228	Target Neighborhood Hits	281	Shared Neighborhood Hits	43
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

PPIP1_MOUSE
NC score	0.217783 (rank : 87)	θ value	0.00665767 (rank : 78)
Query Neighborhood Hits	228	Target Neighborhood Hits	377	Shared Neighborhood Hits	100
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

ABI2_MOUSE
NC score	0.214332 (rank : 88)	θ value	0.21417 (rank : 105)
Query Neighborhood Hits	228	Target Neighborhood Hits	266	Shared Neighborhood Hits	84
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI1_MOUSE
NC score	0.213666 (rank : 89)	θ value	0.125558 (rank : 101)
Query Neighborhood Hits	228	Target Neighborhood Hits	246	Shared Neighborhood Hits	84
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

SOS2_HUMAN
NC score	0.213226 (rank : 90)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	228	Target Neighborhood Hits	193	Shared Neighborhood Hits	41
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

ABI2_HUMAN
NC score	0.212229 (rank : 91)	θ value	0.21417 (rank : 104)
Query Neighborhood Hits	228	Target Neighborhood Hits	350	Shared Neighborhood Hits	85
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI1_HUMAN
NC score	0.202948 (rank : 92)	θ value	0.365318 (rank : 115)
Query Neighborhood Hits	228	Target Neighborhood Hits	257	Shared Neighborhood Hits	84
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

BI2L1_HUMAN
NC score	0.195039 (rank : 93)	θ value	0.00869519 (rank : 79)
Query Neighborhood Hits	228	Target Neighborhood Hits	156	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

LASP1_HUMAN
NC score	0.191978 (rank : 94)	θ value	0.62314 (rank : 131)
Query Neighborhood Hits	228	Target Neighborhood Hits	293	Shared Neighborhood Hits	82
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

ABI3_HUMAN
NC score	0.191827 (rank : 95)	θ value	1.38821 (rank : 145)
Query Neighborhood Hits	228	Target Neighborhood Hits	227	Shared Neighborhood Hits	75
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
NC score	0.190961 (rank : 96)	θ value	1.06291 (rank : 138)
Query Neighborhood Hits	228	Target Neighborhood Hits	227	Shared Neighborhood Hits	78
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

LASP1_MOUSE
NC score	0.189010 (rank : 97)	θ value	0.62314 (rank : 132)
Query Neighborhood Hits	228	Target Neighborhood Hits	297	Shared Neighborhood Hits	82
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

PLCG1_MOUSE
NC score	0.186686 (rank : 98)	θ value	0.000158464 (rank : 60)
Query Neighborhood Hits	228	Target Neighborhood Hits	314	Shared Neighborhood Hits	75
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

DUET_HUMAN
NC score	0.183966 (rank : 99)	θ value	4.92598e-06 (rank : 53)
Query Neighborhood Hits	228	Target Neighborhood Hits	1220	Shared Neighborhood Hits	101
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

GRAP_HUMAN
NC score	0.181524 (rank : 100)	θ value	2.36792 (rank : 162)
Query Neighborhood Hits	228	Target Neighborhood Hits	307	Shared Neighborhood Hits	85
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
NC score	0.181522 (rank : 101)	θ value	8.99809 (rank : 216)
Query Neighborhood Hits	228	Target Neighborhood Hits	309	Shared Neighborhood Hits	88
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

NCF4_MOUSE
NC score	0.179478 (rank : 102)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	228	Target Neighborhood Hits	177	Shared Neighborhood Hits	73
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

PLCG1_HUMAN
NC score	0.179238 (rank : 103)	θ value	0.000270298 (rank : 63)
Query Neighborhood Hits	228	Target Neighborhood Hits	293	Shared Neighborhood Hits	73
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

BI2L1_MOUSE
NC score	0.177911 (rank : 104)	θ value	0.00509761 (rank : 77)
Query Neighborhood Hits	228	Target Neighborhood Hits	197	Shared Neighborhood Hits	50
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

PKHF2_HUMAN
NC score	0.174281 (rank : 105)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	228	Target Neighborhood Hits	75	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
NC score	0.173696 (rank : 106)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	228	Target Neighborhood Hits	77	Shared Neighborhood Hits	17
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

AHI1_HUMAN
NC score	0.170147 (rank : 107)	θ value	0.00390308 (rank : 73)
Query Neighborhood Hits	228	Target Neighborhood Hits	537	Shared Neighborhood Hits	86
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

NCF4_HUMAN
NC score	0.169672 (rank : 108)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	228	Target Neighborhood Hits	161	Shared Neighborhood Hits	65
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

AHI1_MOUSE
NC score	0.167036 (rank : 109)	θ value	0.0193708 (rank : 82)
Query Neighborhood Hits	228	Target Neighborhood Hits	496	Shared Neighborhood Hits	85
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

STAM1_HUMAN
NC score	0.165871 (rank : 110)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	228	Target Neighborhood Hits	271	Shared Neighborhood Hits	79
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
NC score	0.165773 (rank : 111)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	228	Target Neighborhood Hits	273	Shared Neighborhood Hits	78
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

TRIO_HUMAN
NC score	0.165722 (rank : 112)	θ value	0.000602161 (rank : 67)
Query Neighborhood Hits	228	Target Neighborhood Hits	1580	Shared Neighborhood Hits	113
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

GRB2_HUMAN
NC score	0.165536 (rank : 113)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	228	Target Neighborhood Hits	310	Shared Neighborhood Hits	81
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.165437 (rank : 114)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	228	Target Neighborhood Hits	312	Shared Neighborhood Hits	81
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

NEBL_HUMAN
NC score	0.164842 (rank : 115)	θ value	3.0926 (rank : 172)
Query Neighborhood Hits	228	Target Neighborhood Hits	457	Shared Neighborhood Hits	94
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

SRC8_MOUSE
NC score	0.164278 (rank : 116)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	228	Target Neighborhood Hits	292	Shared Neighborhood Hits	83
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRC8_HUMAN
NC score	0.164268 (rank : 117)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	228	Target Neighborhood Hits	269	Shared Neighborhood Hits	82
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

HCLS1_MOUSE
NC score	0.163573 (rank : 118)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	228	Target Neighborhood Hits	329	Shared Neighborhood Hits	87
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

STAC_HUMAN
NC score	0.163076 (rank : 119)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	228	Target Neighborhood Hits	276	Shared Neighborhood Hits	86
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

PKHF1_HUMAN
NC score	0.162348 (rank : 120)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	228	Target Neighborhood Hits	76	Shared Neighborhood Hits	17
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

STAM2_MOUSE
NC score	0.162178 (rank : 121)	θ value	1.06291 (rank : 143)
Query Neighborhood Hits	228	Target Neighborhood Hits	285	Shared Neighborhood Hits	78
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

PACN2_MOUSE
NC score	0.161691 (rank : 122)	θ value	1.06291 (rank : 140)
Query Neighborhood Hits	228	Target Neighborhood Hits	382	Shared Neighborhood Hits	95
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PKHF1_MOUSE
NC score	0.161456 (rank : 123)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	228	Target Neighborhood Hits	80	Shared Neighborhood Hits	16
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

STAM2_HUMAN
NC score	0.161024 (rank : 124)	θ value	2.36792 (rank : 163)
Query Neighborhood Hits	228	Target Neighborhood Hits	288	Shared Neighborhood Hits	79
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

HCLS1_HUMAN
NC score	0.160500 (rank : 125)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	228	Target Neighborhood Hits	358	Shared Neighborhood Hits	84
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

STAC_MOUSE
NC score	0.158282 (rank : 126)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	228	Target Neighborhood Hits	268	Shared Neighborhood Hits	86
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

PACN2_HUMAN
NC score	0.156768 (rank : 127)	θ value	0.813845 (rank : 137)
Query Neighborhood Hits	228	Target Neighborhood Hits	339	Shared Neighborhood Hits	90
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN1_HUMAN
NC score	0.154944 (rank : 128)	θ value	0.47712 (rank : 123)
Query Neighborhood Hits	228	Target Neighborhood Hits	320	Shared Neighborhood Hits	85
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
NC score	0.154223 (rank : 129)	θ value	0.47712 (rank : 124)
Query Neighborhood Hits	228	Target Neighborhood Hits	283	Shared Neighborhood Hits	83
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN3_MOUSE
NC score	0.153315 (rank : 130)	θ value	3.0926 (rank : 176)
Query Neighborhood Hits	228	Target Neighborhood Hits	380	Shared Neighborhood Hits	78
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PACN3_HUMAN
NC score	0.152831 (rank : 131)	θ value	3.0926 (rank : 175)
Query Neighborhood Hits	228	Target Neighborhood Hits	385	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

NOXO1_MOUSE
NC score	0.152722 (rank : 132)	θ value	1.81305 (rank : 158)
Query Neighborhood Hits	228	Target Neighborhood Hits	114	Shared Neighborhood Hits	54
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_MOUSE
NC score	0.152001 (rank : 133)	θ value	0.47712 (rank : 122)
Query Neighborhood Hits	228	Target Neighborhood Hits	267	Shared Neighborhood Hits	72
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

CRKL_HUMAN
NC score	0.151346 (rank : 134)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	228	Target Neighborhood Hits	313	Shared Neighborhood Hits	76
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

SH3G1_HUMAN
NC score	0.150809 (rank : 135)	θ value	5.27518 (rank : 197)
Query Neighborhood Hits	228	Target Neighborhood Hits	307	Shared Neighborhood Hits	84
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G3_MOUSE
NC score	0.150691 (rank : 136)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	228	Target Neighborhood Hits	236	Shared Neighborhood Hits	78
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

GRAP2_MOUSE
NC score	0.150448 (rank : 137)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	228	Target Neighborhood Hits	297	Shared Neighborhood Hits	78
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP2_HUMAN
NC score	0.149915 (rank : 138)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	228	Target Neighborhood Hits	304	Shared Neighborhood Hits	78
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

CRKL_MOUSE
NC score	0.148314 (rank : 139)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	228	Target Neighborhood Hits	307	Shared Neighborhood Hits	75
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

SH3G3_HUMAN
NC score	0.146373 (rank : 140)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	228	Target Neighborhood Hits	222	Shared Neighborhood Hits	79
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

BAIP2_MOUSE
NC score	0.144692 (rank : 141)	θ value	0.62314 (rank : 128)
Query Neighborhood Hits	228	Target Neighborhood Hits	185	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

SH3G2_MOUSE
NC score	0.143936 (rank : 142)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	228	Target Neighborhood Hits	319	Shared Neighborhood Hits	87
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G2_HUMAN
NC score	0.143731 (rank : 143)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	228	Target Neighborhood Hits	324	Shared Neighborhood Hits	86
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

BAIP2_HUMAN
NC score	0.143539 (rank : 144)	θ value	0.62314 (rank : 127)
Query Neighborhood Hits	228	Target Neighborhood Hits	192	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

PLCG2_HUMAN
NC score	0.141264 (rank : 145)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	228	Target Neighborhood Hits	280	Shared Neighborhood Hits	70
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

CRK_MOUSE
NC score	0.140482 (rank : 146)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	228	Target Neighborhood Hits	314	Shared Neighborhood Hits	78
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

STAC3_MOUSE
NC score	0.139884 (rank : 147)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	228	Target Neighborhood Hits	232	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

SH3G1_MOUSE
NC score	0.139366 (rank : 148)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	228	Target Neighborhood Hits	291	Shared Neighborhood Hits	83
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

BIN1_MOUSE
NC score	0.138979 (rank : 149)	θ value	0.0193708 (rank : 84)
Query Neighborhood Hits	228	Target Neighborhood Hits	283	Shared Neighborhood Hits	69
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

STAC3_HUMAN
NC score	0.138358 (rank : 150)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	228	Target Neighborhood Hits	228	Shared Neighborhood Hits	72
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

NPHP1_HUMAN
NC score	0.137188 (rank : 151)	θ value	4.03905 (rank : 183)
Query Neighborhood Hits	228	Target Neighborhood Hits	288	Shared Neighborhood Hits	74
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NEBU_HUMAN
NC score	0.136427 (rank : 152)	θ value	1.81305 (rank : 156)
Query Neighborhood Hits	228	Target Neighborhood Hits	420	Shared Neighborhood Hits	89
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

CRK_HUMAN
NC score	0.136171 (rank : 153)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	228	Target Neighborhood Hits	308	Shared Neighborhood Hits	77
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

BIN1_HUMAN
NC score	0.134485 (rank : 154)	θ value	0.0193708 (rank : 83)
Query Neighborhood Hits	228	Target Neighborhood Hits	335	Shared Neighborhood Hits	69
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

DBNL_HUMAN
NC score	0.132214 (rank : 155)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	228	Target Neighborhood Hits	244	Shared Neighborhood Hits	75
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

OSTF1_HUMAN
NC score	0.129361 (rank : 156)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	228	Target Neighborhood Hits	466	Shared Neighborhood Hits	84
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

TCGAP_MOUSE
NC score	0.127554 (rank : 157)	θ value	0.0431538 (rank : 93)
Query Neighborhood Hits	228	Target Neighborhood Hits	409	Shared Neighborhood Hits	81
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

DBNL_MOUSE
NC score	0.126656 (rank : 158)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	228	Target Neighborhood Hits	306	Shared Neighborhood Hits	73
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

OSTF1_MOUSE
NC score	0.126090 (rank : 159)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	228	Target Neighborhood Hits	467	Shared Neighborhood Hits	84
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

NOXO1_HUMAN
NC score	0.125195 (rank : 160)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	228	Target Neighborhood Hits	100	Shared Neighborhood Hits	47
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

SHAN2_MOUSE
NC score	0.116657 (rank : 161)	θ value	6.88961 (rank : 210)
Query Neighborhood Hits	228	Target Neighborhood Hits	446	Shared Neighborhood Hits	71
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

JIP2_HUMAN
NC score	0.115928 (rank : 162)	θ value	0.21417 (rank : 106)
Query Neighborhood Hits	228	Target Neighborhood Hits	288	Shared Neighborhood Hits	51
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

AMPH_HUMAN
NC score	0.114842 (rank : 163)	θ value	5.27518 (rank : 188)
Query Neighborhood Hits	228	Target Neighborhood Hits	455	Shared Neighborhood Hits	74
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

TCGAP_HUMAN
NC score	0.114614 (rank : 164)	θ value	0.0431538 (rank : 92)
Query Neighborhood Hits	228	Target Neighborhood Hits	872	Shared Neighborhood Hits	93
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

JIP2_MOUSE
NC score	0.113309 (rank : 165)	θ value	0.21417 (rank : 107)
Query Neighborhood Hits	228	Target Neighborhood Hits	144	Shared Neighborhood Hits	41
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

EFS_MOUSE
NC score	0.112885 (rank : 166)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	228	Target Neighborhood Hits	389	Shared Neighborhood Hits	80
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

BCAR1_MOUSE
NC score	0.111162 (rank : 167)	θ value	8.99809 (rank : 214)
Query Neighborhood Hits	228	Target Neighborhood Hits	438	Shared Neighborhood Hits	79
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

ZFY28_HUMAN
NC score	0.110565 (rank : 168)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	228	Target Neighborhood Hits	152	Shared Neighborhood Hits	13
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV9_HUMAN
NC score	0.108068 (rank : 169)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	228	Target Neighborhood Hits	134	Shared Neighborhood Hits	12
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

CT032_HUMAN
NC score	0.107030 (rank : 170)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	228	Target Neighborhood Hits	235	Shared Neighborhood Hits	68
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

STS2_HUMAN
NC score	0.105846 (rank : 171)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	228	Target Neighborhood Hits	108	Shared Neighborhood Hits	54
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

BCAR1_HUMAN
NC score	0.104634 (rank : 172)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	228	Target Neighborhood Hits	554	Shared Neighborhood Hits	80
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

EFS_HUMAN
NC score	0.103635 (rank : 173)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	228	Target Neighborhood Hits	348	Shared Neighborhood Hits	79
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

ZFY16_MOUSE
NC score	0.102121 (rank : 174)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	228	Target Neighborhood Hits	108	Shared Neighborhood Hits	11
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

RHG04_HUMAN
NC score	0.102086 (rank : 175)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	228	Target Neighborhood Hits	307	Shared Neighborhood Hits	75
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

MYO1F_MOUSE
NC score	0.101500 (rank : 176)	θ value	0.00228821 (rank : 71)
Query Neighborhood Hits	228	Target Neighborhood Hits	262	Shared Neighborhood Hits	79
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

SNX18_MOUSE
NC score	0.101229 (rank : 177)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	228	Target Neighborhood Hits	198	Shared Neighborhood Hits	63
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

MYO1F_HUMAN
NC score	0.101204 (rank : 178)	θ value	0.00175202 (rank : 69)
Query Neighborhood Hits	228	Target Neighborhood Hits	275	Shared Neighborhood Hits	79
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

RIMB2_MOUSE
NC score	0.100029 (rank : 179)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	228	Target Neighborhood Hits	246	Shared Neighborhood Hits	58
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

ZFY16_HUMAN
NC score	0.099775 (rank : 180)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	228	Target Neighborhood Hits	125	Shared Neighborhood Hits	14
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

AMPH_MOUSE
NC score	0.099490 (rank : 181)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	228	Target Neighborhood Hits	291	Shared Neighborhood Hits	57
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

SNX18_HUMAN
NC score	0.099355 (rank : 182)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	228	Target Neighborhood Hits	207	Shared Neighborhood Hits	64
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

ZFY21_MOUSE
NC score	0.098970 (rank : 183)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	228	Target Neighborhood Hits	72	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

CASL_HUMAN
NC score	0.098532 (rank : 184)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	228	Target Neighborhood Hits	259	Shared Neighborhood Hits	72
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

MYO1E_HUMAN
NC score	0.098216 (rank : 185)	θ value	0.0961366 (rank : 98)
Query Neighborhood Hits	228	Target Neighborhood Hits	293	Shared Neighborhood Hits	84
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

SHAN1_HUMAN
NC score	0.097994 (rank : 186)	θ value	0.62314 (rank : 135)
Query Neighborhood Hits	228	Target Neighborhood Hits	1041	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

RIMB2_HUMAN
NC score	0.097087 (rank : 187)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	228	Target Neighborhood Hits	263	Shared Neighborhood Hits	61
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

PEX13_MOUSE
NC score	0.095973 (rank : 188)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	228	Target Neighborhood Hits	126	Shared Neighborhood Hits	56
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

ZFY21_HUMAN
NC score	0.095902 (rank : 189)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	228	Target Neighborhood Hits	72	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

CASL_MOUSE
NC score	0.095624 (rank : 190)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	228	Target Neighborhood Hits	225	Shared Neighborhood Hits	69
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

ANM2_HUMAN
NC score	0.093497 (rank : 191)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	228	Target Neighborhood Hits	175	Shared Neighborhood Hits	64
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

RBNS5_HUMAN
NC score	0.092965 (rank : 192)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	228	Target Neighborhood Hits	242	Shared Neighborhood Hits	23
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

STS1_HUMAN
NC score	0.092659 (rank : 193)	θ value	3.0926 (rank : 179)
Query Neighborhood Hits	228	Target Neighborhood Hits	106	Shared Neighborhood Hits	53
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

HGS_MOUSE
NC score	0.090333 (rank : 194)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	228	Target Neighborhood Hits	589	Shared Neighborhood Hits	32
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

ANM2_MOUSE
NC score	0.090037 (rank : 195)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	228	Target Neighborhood Hits	175	Shared Neighborhood Hits	61
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

PEX13_HUMAN
NC score	0.090034 (rank : 196)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	228	Target Neighborhood Hits	128	Shared Neighborhood Hits	49
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

HGS_HUMAN
NC score	0.088983 (rank : 197)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	228	Target Neighborhood Hits	517	Shared Neighborhood Hits	29
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

STS1_MOUSE
NC score	0.088652 (rank : 198)	θ value	5.27518 (rank : 198)
Query Neighborhood Hits	228	Target Neighborhood Hits	104	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

DDEF2_MOUSE
NC score	0.085393 (rank : 199)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	228	Target Neighborhood Hits	625	Shared Neighborhood Hits	89
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_HUMAN
NC score	0.085377 (rank : 200)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	228	Target Neighborhood Hits	599	Shared Neighborhood Hits	90
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

SNX9_HUMAN
NC score	0.083223 (rank : 201)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	228	Target Neighborhood Hits	148	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

RHG26_HUMAN
NC score	0.083023 (rank : 202)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	228	Target Neighborhood Hits	281	Shared Neighborhood Hits	73
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

P85A_HUMAN
NC score	0.083014 (rank : 203)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	228	Target Neighborhood Hits	479	Shared Neighborhood Hits	70
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SRGP2_MOUSE
NC score	0.082784 (rank : 204)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	228	Target Neighborhood Hits	324	Shared Neighborhood Hits	76
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

P85A_MOUSE
NC score	0.082732 (rank : 205)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	228	Target Neighborhood Hits	435	Shared Neighborhood Hits	70
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SRGP1_HUMAN
NC score	0.081850 (rank : 206)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	228	Target Neighborhood Hits	390	Shared Neighborhood Hits	77
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
NC score	0.081677 (rank : 207)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	228	Target Neighborhood Hits	331	Shared Neighborhood Hits	79
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

IASPP_HUMAN
NC score	0.081223 (rank : 208)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	228	Target Neighborhood Hits	688	Shared Neighborhood Hits	80
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

FNBP2_HUMAN
NC score	0.080936 (rank : 209)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	228	Target Neighborhood Hits	432	Shared Neighborhood Hits	78
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

RBNS5_MOUSE
NC score	0.080484 (rank : 210)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	228	Target Neighborhood Hits	266	Shared Neighborhood Hits	17
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

DOCK1_HUMAN
NC score	0.080290 (rank : 211)	θ value	0.62314 (rank : 130)
Query Neighborhood Hits	228	Target Neighborhood Hits	191	Shared Neighborhood Hits	66
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

IASPP_MOUSE
NC score	0.079563 (rank : 212)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	228	Target Neighborhood Hits	1024	Shared Neighborhood Hits	91
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

REPS2_HUMAN
NC score	0.079137 (rank : 213)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	228	Target Neighborhood Hits	131	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

RUSC1_HUMAN
NC score	0.078913 (rank : 214)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	228	Target Neighborhood Hits	226	Shared Neighborhood Hits	56
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

DDEF1_MOUSE
NC score	0.078262 (rank : 215)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	228	Target Neighborhood Hits	592	Shared Neighborhood Hits	76
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

REPS2_MOUSE
NC score	0.077025 (rank : 216)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	228	Target Neighborhood Hits	102	Shared Neighborhood Hits	8
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

GRP3_HUMAN
NC score	0.076324 (rank : 217)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	228	Target Neighborhood Hits	131	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

JIP1_HUMAN
NC score	0.076322 (rank : 218)	θ value	6.88961 (rank : 205)
Query Neighborhood Hits	228	Target Neighborhood Hits	271	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

ASPP1_MOUSE
NC score	0.075893 (rank : 219)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	228	Target Neighborhood Hits	1244	Shared Neighborhood Hits	102
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

SPTA2_HUMAN
NC score	0.074763 (rank : 220)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	228	Target Neighborhood Hits	888	Shared Neighborhood Hits	90
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

JIP1_MOUSE
NC score	0.073302 (rank : 221)	θ value	6.88961 (rank : 206)
Query Neighborhood Hits	228	Target Neighborhood Hits	259	Shared Neighborhood Hits	44
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

REPS1_MOUSE
NC score	0.072714 (rank : 222)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	228	Target Neighborhood Hits	204	Shared Neighborhood Hits	15
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

RUSC1_MOUSE
NC score	0.072040 (rank : 223)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	228	Target Neighborhood Hits	206	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

ZFY19_HUMAN
NC score	0.071387 (rank : 224)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	228	Target Neighborhood Hits	206	Shared Neighborhood Hits	12
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ES8L3_MOUSE
NC score	0.070423 (rank : 225)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	228	Target Neighborhood Hits	168	Shared Neighborhood Hits	57
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

P85B_HUMAN
NC score	0.069926 (rank : 226)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	228	Target Neighborhood Hits	543	Shared Neighborhood Hits	52
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

ZFY19_MOUSE
NC score	0.068855 (rank : 227)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	228	Target Neighborhood Hits	143	Shared Neighborhood Hits	13
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

ASPP1_HUMAN
NC score	0.067744 (rank : 228)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	228	Target Neighborhood Hits	956	Shared Neighborhood Hits	87
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

PKHA6_MOUSE
NC score	0.067148 (rank : 229)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	228	Target Neighborhood Hits	591	Shared Neighborhood Hits	36
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

REPS1_HUMAN
NC score	0.066699 (rank : 230)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	228	Target Neighborhood Hits	205	Shared Neighborhood Hits	14
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

SPTA1_MOUSE
NC score	0.066103 (rank : 231)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	228	Target Neighborhood Hits	675	Shared Neighborhood Hits	73
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

P85B_MOUSE
NC score	0.065670 (rank : 232)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	228	Target Neighborhood Hits	519	Shared Neighborhood Hits	50
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SHLB1_HUMAN
NC score	0.064745 (rank : 233)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	228	Target Neighborhood Hits	96	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

ES8L3_HUMAN
NC score	0.064425 (rank : 234)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	228	Target Neighborhood Hits	206	Shared Neighborhood Hits	48
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

PKHA6_HUMAN
NC score	0.064205 (rank : 235)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	228	Target Neighborhood Hits	556	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

RUFY2_HUMAN
NC score	0.063932 (rank : 236)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	228	Target Neighborhood Hits	1208	Shared Neighborhood Hits	44
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

SPTA1_HUMAN
NC score	0.063738 (rank : 237)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	228	Target Neighborhood Hits	748	Shared Neighborhood Hits	81
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

RUFY2_MOUSE
NC score	0.063618 (rank : 238)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	228	Target Neighborhood Hits	820	Shared Neighborhood Hits	30
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

SHLB2_MOUSE
NC score	0.062772 (rank : 239)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	228	Target Neighborhood Hits	88	Shared Neighborhood Hits	32
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

RUFY1_MOUSE
NC score	0.062771 (rank : 240)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	228	Target Neighborhood Hits	765	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RIMB1_HUMAN
NC score	0.062495 (rank : 241)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	228	Target Neighborhood Hits	1479	Shared Neighborhood Hits	100
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SHLB2_HUMAN
NC score	0.062410 (rank : 242)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	228	Target Neighborhood Hits	86	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

RUFY1_HUMAN
NC score	0.062366 (rank : 243)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	228	Target Neighborhood Hits	848	Shared Neighborhood Hits	38
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

FYV1_HUMAN
NC score	0.061486 (rank : 244)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	228	Target Neighborhood Hits	217	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

ES8L2_MOUSE
NC score	0.061405 (rank : 245)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	228	Target Neighborhood Hits	169	Shared Neighborhood Hits	54
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

SHLB1_MOUSE
NC score	0.061394 (rank : 246)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	228	Target Neighborhood Hits	101	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

ZFYV1_HUMAN
NC score	0.060948 (rank : 247)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	228	Target Neighborhood Hits	166	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

SNX9_MOUSE
NC score	0.060675 (rank : 248)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	228	Target Neighborhood Hits	141	Shared Neighborhood Hits	46
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

OBSCN_HUMAN
NC score	0.060583 (rank : 249)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	228	Target Neighborhood Hits	1931	Shared Neighborhood Hits	91
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

FYV1_MOUSE
NC score	0.060550 (rank : 250)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	228	Target Neighborhood Hits	191	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

ZFYV1_MOUSE
NC score	0.059864 (rank : 251)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	228	Target Neighborhood Hits	153	Shared Neighborhood Hits	11
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

SRRM1_MOUSE
NC score	0.058838 (rank : 252)	θ value	0.0563607 (rank : 94)
Query Neighborhood Hits	228	Target Neighborhood Hits	966	Shared Neighborhood Hits	55
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

SLY_MOUSE
NC score	0.058517 (rank : 253)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	228	Target Neighborhood Hits	108	Shared Neighborhood Hits	40
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

ES8L2_HUMAN
NC score	0.058217 (rank : 254)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	228	Target Neighborhood Hits	193	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

RPGF1_HUMAN
NC score	0.057571 (rank : 255)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	228	Target Neighborhood Hits	262	Shared Neighborhood Hits	21
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

ZC313_HUMAN
NC score	0.056928 (rank : 256)	θ value	0.21417 (rank : 110)
Query Neighborhood Hits	228	Target Neighborhood Hits	772	Shared Neighborhood Hits	34
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

WDFY1_HUMAN
NC score	0.056898 (rank : 257)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	228	Target Neighborhood Hits	305	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

PPIP2_HUMAN
NC score	0.055962 (rank : 258)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	228	Target Neighborhood Hits	254	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

RIMB1_MOUSE
NC score	0.055889 (rank : 259)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	228	Target Neighborhood Hits	1376	Shared Neighborhood Hits	98
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

ASPP2_HUMAN
NC score	0.055036 (rank : 260)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	228	Target Neighborhood Hits	1156	Shared Neighborhood Hits	81
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

EPS8_MOUSE
NC score	0.055011 (rank : 261)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	228	Target Neighborhood Hits	157	Shared Neighborhood Hits	50
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

WDFY3_HUMAN
NC score	0.054702 (rank : 262)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	228	Target Neighborhood Hits	348	Shared Neighborhood Hits	17
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

EP15R_MOUSE
NC score	0.053965 (rank : 263)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	228	Target Neighborhood Hits	1135	Shared Neighborhood Hits	32
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

SHE_MOUSE
NC score	0.053786 (rank : 264)	θ value	3.0926 (rank : 178)
Query Neighborhood Hits	228	Target Neighborhood Hits	169	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

FXL19_MOUSE
NC score	0.053692 (rank : 265)	θ value	0.00390308 (rank : 75)
Query Neighborhood Hits	228	Target Neighborhood Hits	217	Shared Neighborhood Hits	13
SwissProt Accessions	Q6PB97, Q7TSH0, Q8BIB4	Gene names	Fbxl19
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19).

EEA1_HUMAN
NC score	0.053541 (rank : 266)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	228	Target Neighborhood Hits	1796	Shared Neighborhood Hits	61
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

WDFY3_MOUSE
NC score	0.053500 (rank : 267)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	228	Target Neighborhood Hits	332	Shared Neighborhood Hits	12
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

EP15_HUMAN
NC score	0.053463 (rank : 268)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	228	Target Neighborhood Hits	1021	Shared Neighborhood Hits	37
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EEA1_MOUSE
NC score	0.053313 (rank : 269)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	228	Target Neighborhood Hits	1637	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

EP15_MOUSE
NC score	0.053266 (rank : 270)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	228	Target Neighborhood Hits	820	Shared Neighborhood Hits	26
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

ES8L1_MOUSE
NC score	0.052891 (rank : 271)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	228	Target Neighborhood Hits	143	Shared Neighborhood Hits	35
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

EHD1_HUMAN
NC score	0.052126 (rank : 272)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	228	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H4M9, O14611, Q9UNR3	Gene names	EHD1, PAST, PAST1
Domain Architecture
Description	EH-domain-containing protein 1 (Testilin) (hPAST1).

EHD1_MOUSE
NC score	0.052042 (rank : 273)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	228	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WVK4	Gene names	Ehd1, Past1
Domain Architecture
Description	EH-domain-containing protein 1 (mPAST1).

EPS8_HUMAN
NC score	0.051819 (rank : 274)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	228	Target Neighborhood Hits	151	Shared Neighborhood Hits	47
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EP15R_HUMAN
NC score	0.051817 (rank : 275)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	228	Target Neighborhood Hits	1083	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

SRRM2_MOUSE
NC score	0.051797 (rank : 276)	θ value	0.21417 (rank : 109)
Query Neighborhood Hits	228	Target Neighborhood Hits	1470	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

DAPP1_MOUSE
NC score	0.051718 (rank : 277)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	228	Target Neighborhood Hits	225	Shared Neighborhood Hits	18
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PPIP2_MOUSE
NC score	0.051628 (rank : 278)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	228	Target Neighborhood Hits	308	Shared Neighborhood Hits	22
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

EHD2_HUMAN
NC score	0.051485 (rank : 279)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	228	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZN4, Q96CB6	Gene names	EHD2
Domain Architecture
Description	EH-domain-containing protein 2.

EHD3_HUMAN
NC score	0.051475 (rank : 280)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	228	Target Neighborhood Hits	33	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZN3, Q8N514, Q9NZB3	Gene names	EHD3, EHD2
Domain Architecture
Description	EH-domain-containing protein 3.

DAPP1_HUMAN
NC score	0.051405 (rank : 281)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	228	Target Neighborhood Hits	227	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

SLY_HUMAN
NC score	0.051267 (rank : 282)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	228	Target Neighborhood Hits	81	Shared Neighborhood Hits	35
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

MIA_HUMAN
NC score	0.051248 (rank : 283)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	228	Target Neighborhood Hits	19	Shared Neighborhood Hits	11
SwissProt Accessions	Q16674	Gene names	MIA
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity).

RASA1_HUMAN
NC score	0.051183 (rank : 284)	θ value	1.38821 (rank : 150)
Query Neighborhood Hits	228	Target Neighborhood Hits	258	Shared Neighborhood Hits	36
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

EHD3_MOUSE
NC score	0.051069 (rank : 285)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	228	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QXY6	Gene names	Ehd3, Ehd2
Domain Architecture
Description	EH-domain-containing protein 3.

EHD4_MOUSE
NC score	0.050884 (rank : 286)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	228	Target Neighborhood Hits	40	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EQP2	Gene names	Ehd4, Past2
Domain Architecture
Description	EH-domain-containing protein 4 (mPAST2).

FXL19_HUMAN
NC score	0.050746 (rank : 287)	θ value	0.00298849 (rank : 72)
Query Neighborhood Hits	228	Target Neighborhood Hits	147	Shared Neighborhood Hits	7
SwissProt Accessions	Q6PCT2, Q8N789, Q9NT14	Gene names	FBXL19, FBL19
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19).

SNIP1_HUMAN
NC score	0.050560 (rank : 288)	θ value	0.00869519 (rank : 81)
Query Neighborhood Hits	228	Target Neighborhood Hits	80	Shared Neighborhood Hits	9
SwissProt Accessions	Q8TAD8, Q96SP9, Q9H9T7	Gene names	SNIP1
Domain Architecture
Description	Smad nuclear-interacting protein 1.

MIA_MOUSE
NC score	0.050374 (rank : 289)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	228	Target Neighborhood Hits	17	Shared Neighborhood Hits	9
SwissProt Accessions	Q61865, O09086, P97495	Gene names	Mia, Cdrap, Mia1
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity) (Cartilage-derived retinoic acid-sensitive protein) (CD-RAP).

CENPH_MOUSE
NC score	0.050270 (rank : 290)	θ value	0.279714 (rank : 111)
Query Neighborhood Hits	228	Target Neighborhood Hits	195	Shared Neighborhood Hits	10
SwissProt Accessions	Q9QYM8, Q8R3K9, Q9D079, Q9D0N1	Gene names	Cenph, Enp
Domain Architecture	No domain graphic available
Description	Centromere protein H (CENP-H).

SPN90_HUMAN
NC score	0.050139 (rank : 291)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	228	Target Neighborhood Hits	157	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

ALS2_MOUSE
NC score	0.050128 (rank : 292)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	228	Target Neighborhood Hits	111	Shared Neighborhood Hits	16
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

SRRM1_HUMAN
NC score	0.050050 (rank : 293)	θ value	0.125558 (rank : 102)
Query Neighborhood Hits	228	Target Neighborhood Hits	690	Shared Neighborhood Hits	46
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

CCD96_MOUSE
NC score	0.047139 (rank : 294)	θ value	1.38821 (rank : 147)
Query Neighborhood Hits	228	Target Neighborhood Hits	704	Shared Neighborhood Hits	32
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

AFF4_HUMAN
NC score	0.042302 (rank : 295)	θ value	0.0431538 (rank : 91)
Query Neighborhood Hits	228	Target Neighborhood Hits	611	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UHB7, Q498B2, Q59FB3, Q6P592, Q8TDR1, Q9P0E4	Gene names	AFF4, AF5Q31, MCEF
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31) (Major CDK9 elongation factor-associated protein).

AFF4_MOUSE
NC score	0.040509 (rank : 296)	θ value	0.365318 (rank : 117)
Query Neighborhood Hits	228	Target Neighborhood Hits	581	Shared Neighborhood Hits	34
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

CN045_HUMAN
NC score	0.038722 (rank : 297)	θ value	1.06291 (rank : 139)
Query Neighborhood Hits	228	Target Neighborhood Hits	227	Shared Neighborhood Hits	10
SwissProt Accessions	Q8ND07, Q9H5P8	Gene names	C14orf45
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf45.

MINT_HUMAN
NC score	0.038522 (rank : 298)	θ value	0.279714 (rank : 112)
Query Neighborhood Hits	228	Target Neighborhood Hits	1291	Shared Neighborhood Hits	55
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

FGR_MOUSE
NC score	0.037824 (rank : 299)	θ value	6.88961 (rank : 204)
Query Neighborhood Hits	228	Target Neighborhood Hits	1069	Shared Neighborhood Hits	89
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

MUC7_HUMAN
NC score	0.037491 (rank : 300)	θ value	0.279714 (rank : 113)
Query Neighborhood Hits	228	Target Neighborhood Hits	538	Shared Neighborhood Hits	26
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

SRRM2_HUMAN
NC score	0.037391 (rank : 301)	θ value	4.03905 (rank : 187)
Query Neighborhood Hits	228	Target Neighborhood Hits	1296	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

PRR12_HUMAN
NC score	0.037319 (rank : 302)	θ value	0.62314 (rank : 133)
Query Neighborhood Hits	228	Target Neighborhood Hits	460	Shared Neighborhood Hits	30
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

SFR11_HUMAN
NC score	0.037224 (rank : 303)	θ value	0.62314 (rank : 134)
Query Neighborhood Hits	228	Target Neighborhood Hits	246	Shared Neighborhood Hits	21
SwissProt Accessions	Q05519	Gene names	SFRS11
Domain Architecture
Description	Splicing factor arginine/serine-rich 11 (Arginine-rich 54 kDa nuclear protein) (p54).

NPBL_MOUSE
NC score	0.037039 (rank : 304)	θ value	8.99809 (rank : 220)
Query Neighborhood Hits	228	Target Neighborhood Hits	1041	Shared Neighborhood Hits	50
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

TCOF_HUMAN
NC score	0.035868 (rank : 305)	θ value	0.365318 (rank : 119)
Query Neighborhood Hits	228	Target Neighborhood Hits	543	Shared Neighborhood Hits	27
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

NEST_HUMAN
NC score	0.034111 (rank : 306)	θ value	1.81305 (rank : 157)
Query Neighborhood Hits	228	Target Neighborhood Hits	1305	Shared Neighborhood Hits	46
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

SFR12_HUMAN
NC score	0.033545 (rank : 307)	θ value	4.03905 (rank : 185)
Query Neighborhood Hits	228	Target Neighborhood Hits	553	Shared Neighborhood Hits	32
SwissProt Accessions	Q8WXA9, Q86X37	Gene names	SFRS12, SRRP86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86) (Splicing regulatory protein 508) (SRrp508).

RILP_HUMAN
NC score	0.032781 (rank : 308)	θ value	1.38821 (rank : 152)
Query Neighborhood Hits	228	Target Neighborhood Hits	249	Shared Neighborhood Hits	16
SwissProt Accessions	Q96NA2, Q71RE6, Q9BSL3, Q9BYS3	Gene names	RILP
Domain Architecture	No domain graphic available
Description	Rab-interacting lysosomal protein.

NFH_MOUSE
NC score	0.031903 (rank : 309)	θ value	0.279714 (rank : 114)
Query Neighborhood Hits	228	Target Neighborhood Hits	2247	Shared Neighborhood Hits	86
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

CJ047_HUMAN
NC score	0.031426 (rank : 310)	θ value	0.47712 (rank : 120)
Query Neighborhood Hits	228	Target Neighborhood Hits	164	Shared Neighborhood Hits	10
SwissProt Accessions	Q86WR7, Q5W0J9, Q5W0K0, Q5W0K1, Q5W0K2, Q6PJC8, Q8N317	Gene names	C10orf47
Domain Architecture	No domain graphic available
Description	Protein C10orf47.

TGON2_HUMAN
NC score	0.030697 (rank : 311)	θ value	6.88961 (rank : 211)
Query Neighborhood Hits	228	Target Neighborhood Hits	1037	Shared Neighborhood Hits	57
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

CIR_MOUSE
NC score	0.030132 (rank : 312)	θ value	0.62314 (rank : 129)
Query Neighborhood Hits	228	Target Neighborhood Hits	255	Shared Neighborhood Hits	14
SwissProt Accessions	Q9DA19, Q3V2N9, Q4KL44, Q52KL9, Q5FW66	Gene names	Cir
Domain Architecture	No domain graphic available
Description	CBF1-interacting corepressor.

C8AP2_HUMAN
NC score	0.029714 (rank : 313)	θ value	3.0926 (rank : 168)
Query Neighborhood Hits	228	Target Neighborhood Hits	548	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UKL3, Q6PH76, Q7LCQ7, Q86YD9, Q9NUQ4, Q9NZV9, Q9P2N1, Q9Y563	Gene names	CASP8AP2, FLASH, KIAA1315, RIP25
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

RIMS1_HUMAN
NC score	0.029236 (rank : 314)	θ value	0.47712 (rank : 125)
Query Neighborhood Hits	228	Target Neighborhood Hits	437	Shared Neighborhood Hits	22
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

SNPC4_HUMAN
NC score	0.028866 (rank : 315)	θ value	1.06291 (rank : 142)
Query Neighborhood Hits	228	Target Neighborhood Hits	589	Shared Neighborhood Hits	23
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

ABL1_HUMAN
NC score	0.028347 (rank : 316)	θ value	0.0736092 (rank : 95)
Query Neighborhood Hits	228	Target Neighborhood Hits	1220	Shared Neighborhood Hits	79
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

TF3C1_HUMAN
NC score	0.027677 (rank : 317)	θ value	0.47712 (rank : 126)
Query Neighborhood Hits	228	Target Neighborhood Hits	88	Shared Neighborhood Hits	9
SwissProt Accessions	Q12789, Q12838, Q9Y4W9	Gene names	GTF3C1
Domain Architecture	No domain graphic available
Description	General transcription factor 3C polypeptide 1 (Transcription factor IIIC-subunit alpha) (TF3C-alpha) (TFIIIC 220 kDa subunit) (TFIIIC220) (TFIIIC box B-binding subunit).

AFAD_HUMAN
NC score	0.027526 (rank : 318)	θ value	8.99809 (rank : 213)
Query Neighborhood Hits	228	Target Neighborhood Hits	689	Shared Neighborhood Hits	30
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

DAAM1_MOUSE
NC score	0.024828 (rank : 319)	θ value	1.81305 (rank : 154)
Query Neighborhood Hits	228	Target Neighborhood Hits	443	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BPM0, Q80Y68, Q9CQQ2	Gene names	Daam1
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 1.

K1802_MOUSE
NC score	0.024344 (rank : 320)	θ value	4.03905 (rank : 182)
Query Neighborhood Hits	228	Target Neighborhood Hits	1596	Shared Neighborhood Hits	57
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

DOCK4_HUMAN
NC score	0.024178 (rank : 321)	θ value	5.27518 (rank : 191)
Query Neighborhood Hits	228	Target Neighborhood Hits	237	Shared Neighborhood Hits	26
SwissProt Accessions	Q8N1I0, O14584, O94824, Q8NB45	Gene names	DOCK4, KIAA0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

K2027_HUMAN
NC score	0.023732 (rank : 322)	θ value	1.81305 (rank : 155)
Query Neighborhood Hits	228	Target Neighborhood Hits	194	Shared Neighborhood Hits	17
SwissProt Accessions	Q6ZVF9, Q8IVE4	Gene names	KIAA2027
Domain Architecture	No domain graphic available
Description	Protein KIAA2027.

RAI14_MOUSE
NC score	0.023528 (rank : 323)	θ value	0.0193708 (rank : 85)
Query Neighborhood Hits	228	Target Neighborhood Hits	1505	Shared Neighborhood Hits	44
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

DOCK4_MOUSE
NC score	0.023452 (rank : 324)	θ value	5.27518 (rank : 192)
Query Neighborhood Hits	228	Target Neighborhood Hits	210	Shared Neighborhood Hits	28
SwissProt Accessions	P59764	Gene names	Dock4, Kiaa0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

MRCKB_MOUSE
NC score	0.023054 (rank : 325)	θ value	5.27518 (rank : 194)
Query Neighborhood Hits	228	Target Neighborhood Hits	2180	Shared Neighborhood Hits	71
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

RBP24_HUMAN
NC score	0.022636 (rank : 326)	θ value	5.27518 (rank : 196)
Query Neighborhood Hits	228	Target Neighborhood Hits	1559	Shared Neighborhood Hits	49
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

GCC2_HUMAN
NC score	0.022586 (rank : 327)	θ value	5.27518 (rank : 193)
Query Neighborhood Hits	228	Target Neighborhood Hits	1558	Shared Neighborhood Hits	49
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

BSCL2_HUMAN
NC score	0.021933 (rank : 328)	θ value	1.38821 (rank : 146)
Query Neighborhood Hits	228	Target Neighborhood Hits	148	Shared Neighborhood Hits	7
SwissProt Accessions	Q96G97, Q96SV1, Q9BSQ0	Gene names	BSCL2
Domain Architecture	No domain graphic available
Description	Seipin (Bernardinelli-Seip congenital lipodystrophy type 2 protein).

DAAM1_HUMAN
NC score	0.021879 (rank : 329)	θ value	1.81305 (rank : 153)
Query Neighborhood Hits	228	Target Neighborhood Hits	483	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y4D1, Q86U34, Q8N1Z8, Q8TB39	Gene names	DAAM1, KIAA0666
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 1.

MRCKB_HUMAN
NC score	0.021692 (rank : 330)	θ value	3.0926 (rank : 171)
Query Neighborhood Hits	228	Target Neighborhood Hits	2239	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

BRCA1_HUMAN
NC score	0.020232 (rank : 331)	θ value	0.365318 (rank : 118)
Query Neighborhood Hits	228	Target Neighborhood Hits	381	Shared Neighborhood Hits	10
SwissProt Accessions	P38398	Gene names	BRCA1, RNF53
Domain Architecture
Description	Breast cancer type 1 susceptibility protein (RING finger protein 53).

NFH_HUMAN
NC score	0.020054 (rank : 332)	θ value	0.21417 (rank : 108)
Query Neighborhood Hits	228	Target Neighborhood Hits	1242	Shared Neighborhood Hits	47
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

PRG4_HUMAN
NC score	0.020007 (rank : 333)	θ value	8.99809 (rank : 222)
Query Neighborhood Hits	228	Target Neighborhood Hits	764	Shared Neighborhood Hits	31
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

3BP1_MOUSE
NC score	0.019444 (rank : 334)	θ value	6.88961 (rank : 199)
Query Neighborhood Hits	228	Target Neighborhood Hits	238	Shared Neighborhood Hits	19
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

CTRO_MOUSE
NC score	0.018609 (rank : 335)	θ value	2.36792 (rank : 161)
Query Neighborhood Hits	228	Target Neighborhood Hits	2344	Shared Neighborhood Hits	66
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

SMG7_MOUSE
NC score	0.017440 (rank : 336)	θ value	4.03905 (rank : 186)
Query Neighborhood Hits	228	Target Neighborhood Hits	113	Shared Neighborhood Hits	9
SwissProt Accessions	Q5RJH6, Q63ZW5, Q6ZQF3	Gene names	Smg7, Est1c, Kiaa0250
Domain Architecture	No domain graphic available
Description	Protein SMG7 (SMG-7 homolog) (EST1-like protein C).

LRSM1_HUMAN
NC score	0.017331 (rank : 337)	θ value	3.0926 (rank : 169)
Query Neighborhood Hits	228	Target Neighborhood Hits	1078	Shared Neighborhood Hits	31
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

VASP_HUMAN
NC score	0.017117 (rank : 338)	θ value	2.36792 (rank : 164)
Query Neighborhood Hits	228	Target Neighborhood Hits	201	Shared Neighborhood Hits	12
SwissProt Accessions	P50552, Q6PIZ1, Q93035	Gene names	VASP
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

NFM_MOUSE
NC score	0.016642 (rank : 339)	θ value	8.99809 (rank : 219)
Query Neighborhood Hits	228	Target Neighborhood Hits	1159	Shared Neighborhood Hits	45
SwissProt Accessions	P08553, Q61961	Gene names	Nef3, Nefm, Nfm
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M).

KIF1A_MOUSE
NC score	0.016487 (rank : 340)	θ value	0.47712 (rank : 121)
Query Neighborhood Hits	228	Target Neighborhood Hits	239	Shared Neighborhood Hits	16
SwissProt Accessions	P33173, Q61770	Gene names	Kif1a, Atsv, Kif1
Domain Architecture
Description	Kinesin-like protein KIF1A (Axonal transporter of synaptic vesicles).

ARI5B_HUMAN
NC score	0.016253 (rank : 341)	θ value	6.88961 (rank : 203)
Query Neighborhood Hits	228	Target Neighborhood Hits	328	Shared Neighborhood Hits	23
SwissProt Accessions	Q14865, Q7Z3M4, Q8N421, Q9H786	Gene names	ARID5B, DESRT, MRF2
Domain Architecture
Description	AT-rich interactive domain-containing protein 5B (ARID domain- containing protein 5B) (Mrf1-like) (Modulator recognition factor 2) (MRF-2).

CTRO_HUMAN
NC score	0.016072 (rank : 342)	θ value	2.36792 (rank : 160)
Query Neighborhood Hits	228	Target Neighborhood Hits	2092	Shared Neighborhood Hits	64
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

PXK_MOUSE
NC score	0.015344 (rank : 343)	θ value	1.06291 (rank : 141)
Query Neighborhood Hits	228	Target Neighborhood Hits	320	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

KIF1A_HUMAN
NC score	0.015004 (rank : 344)	θ value	1.38821 (rank : 148)
Query Neighborhood Hits	228	Target Neighborhood Hits	240	Shared Neighborhood Hits	16
SwissProt Accessions	Q12756	Gene names	KIF1A, ATSV
Domain Architecture
Description	Kinesin-like protein KIF1A (Axonal transporter of synaptic vesicles).

CIZ1_HUMAN
NC score	0.014616 (rank : 345)	θ value	5.27518 (rank : 190)
Query Neighborhood Hits	228	Target Neighborhood Hits	359	Shared Neighborhood Hits	19
SwissProt Accessions	Q9ULV3, Q9NYM8, Q9UHK4, Q9Y3F9, Q9Y3G0	Gene names	CIZ1, LSFR1, NP94
Domain Architecture	No domain graphic available
Description	Cip1-interacting zinc finger protein (Nuclear protein NP94).

SMG7_HUMAN
NC score	0.014481 (rank : 346)	θ value	8.99809 (rank : 227)
Query Neighborhood Hits	228	Target Neighborhood Hits	117	Shared Neighborhood Hits	9
SwissProt Accessions	Q92540, Q5T1Q0, Q6PIE0, Q7Z7H9, Q8IXC1, Q8IXC2	Gene names	SMG7, C1orf16, EST1C, KIAA0250
Domain Architecture
Description	Protein SMG7 (SMG-7 homolog) (EST1-like protein C).

T240L_MOUSE
NC score	0.014382 (rank : 347)	θ value	3.0926 (rank : 180)
Query Neighborhood Hits	228	Target Neighborhood Hits	143	Shared Neighborhood Hits	7
SwissProt Accessions	Q6JPI3, Q3TRF4, Q3UQI8, Q80TM3, Q80WQ0	Gene names	Thrap2, Kiaa1025, Trap240l
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 2 (Thyroid hormone receptor-associated protein complex 240 kDa component-like).

MCM3A_HUMAN
NC score	0.013005 (rank : 348)	θ value	3.0926 (rank : 170)
Query Neighborhood Hits	228	Target Neighborhood Hits	86	Shared Neighborhood Hits	5
SwissProt Accessions	O60318, Q9UMT4	Gene names	MCM3AP, GANP, KIAA0572, MAP80
Domain Architecture
Description	80 kDa MCM3-associated protein (GANP protein).

GEMI5_MOUSE
NC score	0.012887 (rank : 349)	θ value	0.813845 (rank : 136)
Query Neighborhood Hits	228	Target Neighborhood Hits	424	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BX17	Gene names	Gemin5
Domain Architecture
Description	Gem-associated protein 5 (Gemin5).

RBMX2_HUMAN
NC score	0.011690 (rank : 350)	θ value	1.38821 (rank : 151)
Query Neighborhood Hits	228	Target Neighborhood Hits	351	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y388, Q5JY82, Q9Y3I8	Gene names	RBMX2
Domain Architecture
Description	RNA-binding motif protein, X-linked 2.

RNPS1_HUMAN
NC score	0.011313 (rank : 351)	θ value	8.99809 (rank : 224)
Query Neighborhood Hits	228	Target Neighborhood Hits	285	Shared Neighborhood Hits	14
SwissProt Accessions	Q15287, O75308, Q8WY42, Q9NYG3	Gene names	RNPS1, LDC2
Domain Architecture	No domain graphic available
Description	RNA-binding protein with serine-rich domain 1 (SR-related protein LDC2).

RNPS1_MOUSE
NC score	0.011313 (rank : 352)	θ value	8.99809 (rank : 225)
Query Neighborhood Hits	228	Target Neighborhood Hits	285	Shared Neighborhood Hits	14
SwissProt Accessions	Q99M28, Q3TMJ1, Q922H8	Gene names	Rnps1
Domain Architecture	No domain graphic available
Description	RNA-binding protein with serine-rich domain 1.

CD2L1_MOUSE
NC score	0.010820 (rank : 353)	θ value	0.00228821 (rank : 70)
Query Neighborhood Hits	228	Target Neighborhood Hits	1463	Shared Neighborhood Hits	40
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

SLK_MOUSE
NC score	0.010009 (rank : 354)	θ value	8.99809 (rank : 226)
Query Neighborhood Hits	228	Target Neighborhood Hits	1798	Shared Neighborhood Hits	47
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

AQR_HUMAN
NC score	0.008836 (rank : 355)	θ value	6.88961 (rank : 201)
Query Neighborhood Hits	228	Target Neighborhood Hits	88	Shared Neighborhood Hits	7
SwissProt Accessions	O60306, Q2YDX9, Q6IRU8, Q6PIC8	Gene names	AQR, KIAA0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius (Intron-binding protein of 160 kDa) (IBP160).

ACK1_HUMAN
NC score	0.008316 (rank : 356)	θ value	3.0926 (rank : 166)
Query Neighborhood Hits	228	Target Neighborhood Hits	1140	Shared Neighborhood Hits	54
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
NC score	0.008232 (rank : 357)	θ value	3.0926 (rank : 167)
Query Neighborhood Hits	228	Target Neighborhood Hits	1080	Shared Neighborhood Hits	54
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

NFASC_MOUSE
NC score	0.007756 (rank : 358)	θ value	6.88961 (rank : 208)
Query Neighborhood Hits	228	Target Neighborhood Hits	475	Shared Neighborhood Hits	10
SwissProt Accessions	Q810U3	Gene names	Nfasc
Domain Architecture
Description	Neurofascin precursor.

RBM28_MOUSE
NC score	0.007658 (rank : 359)	θ value	8.99809 (rank : 223)
Query Neighborhood Hits	228	Target Neighborhood Hits	368	Shared Neighborhood Hits	22
SwissProt Accessions	Q8CGC6, Q8BG25, Q8VEJ8, Q9CS22, Q9CSE6	Gene names	Rbm28
Domain Architecture	No domain graphic available
Description	RNA-binding protein 28 (RNA-binding motif protein 28).

NRCAM_HUMAN
NC score	0.007655 (rank : 360)	θ value	3.0926 (rank : 173)
Query Neighborhood Hits	228	Target Neighborhood Hits	439	Shared Neighborhood Hits	10
SwissProt Accessions	Q92823, O15051, O15179, Q9UHI3, Q9UHI4	Gene names	NRCAM, KIAA0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (hBravo).

NKRF_HUMAN
NC score	0.007546 (rank : 361)	θ value	6.88961 (rank : 209)
Query Neighborhood Hits	228	Target Neighborhood Hits	57	Shared Neighborhood Hits	2
SwissProt Accessions	O15226, Q9UJ91	Gene names	NKRF, ITBA4, NRF
Domain Architecture
Description	NF-kappa-B-repressing factor (NFKB-repressing factor) (Transcription factor NRF) (ITBA4 protein).

NFASC_HUMAN
NC score	0.007538 (rank : 362)	θ value	6.88961 (rank : 207)
Query Neighborhood Hits	228	Target Neighborhood Hits	497	Shared Neighborhood Hits	11
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

NRCAM_MOUSE
NC score	0.007486 (rank : 363)	θ value	3.0926 (rank : 174)
Query Neighborhood Hits	228	Target Neighborhood Hits	432	Shared Neighborhood Hits	10
SwissProt Accessions	Q810U4, Q80U33, Q8BLG8, Q8BX92, Q8BYJ8	Gene names	Nrcam, Kiaa0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (mBravo).

PHF14_MOUSE
NC score	0.007375 (rank : 364)	θ value	4.03905 (rank : 184)
Query Neighborhood Hits	228	Target Neighborhood Hits	342	Shared Neighborhood Hits	15
SwissProt Accessions	Q9D4H9, Q810Z6, Q8C284, Q8CGF8, Q9D1Q8	Gene names	Phf14
Domain Architecture
Description	PHD finger protein 14.

OSBL5_HUMAN
NC score	0.006841 (rank : 365)	θ value	5.27518 (rank : 195)
Query Neighborhood Hits	228	Target Neighborhood Hits	117	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H0X9, Q9BZB0, Q9P1Z4	Gene names	OSBPL5, KIAA1534, ORP5
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5).

ANR38_HUMAN
NC score	0.006459 (rank : 366)	θ value	6.88961 (rank : 200)
Query Neighborhood Hits	228	Target Neighborhood Hits	443	Shared Neighborhood Hits	15
SwissProt Accessions	Q5T7N3, Q6P9A0, Q86T71, Q86VE6, Q8NAX3	Gene names	ANKRD38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

PRP4B_MOUSE
NC score	0.006388 (rank : 367)	θ value	3.0926 (rank : 177)
Query Neighborhood Hits	228	Target Neighborhood Hits	1040	Shared Neighborhood Hits	32
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

L1CAM_HUMAN
NC score	0.006288 (rank : 368)	θ value	8.99809 (rank : 217)
Query Neighborhood Hits	228	Target Neighborhood Hits	457	Shared Neighborhood Hits	9
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

L1CAM_MOUSE
NC score	0.006223 (rank : 369)	θ value	8.99809 (rank : 218)
Query Neighborhood Hits	228	Target Neighborhood Hits	457	Shared Neighborhood Hits	9
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

FOSL1_MOUSE
NC score	0.005860 (rank : 370)	θ value	8.99809 (rank : 215)
Query Neighborhood Hits	228	Target Neighborhood Hits	113	Shared Neighborhood Hits	4
SwissProt Accessions	P48755, O35285	Gene names	Fosl1, Fra1
Domain Architecture
Description	Fos-related antigen 1 (FRA-1).

WNK2_HUMAN
NC score	0.004005 (rank : 371)	θ value	8.99809 (rank : 228)
Query Neighborhood Hits	228	Target Neighborhood Hits	1407	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

PIWL3_HUMAN
NC score	0.003363 (rank : 372)	θ value	8.99809 (rank : 221)
Query Neighborhood Hits	228	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z3Z3	Gene names	PIWIL3
Domain Architecture	No domain graphic available
Description	Piwi-like protein 3.

PAK3_MOUSE
NC score	0.001649 (rank : 373)	θ value	1.38821 (rank : 149)
Query Neighborhood Hits	228	Target Neighborhood Hits	874	Shared Neighborhood Hits	20
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

ZN238_HUMAN
NC score	-0.003727 (rank : 374)	θ value	1.06291 (rank : 144)
Query Neighborhood Hits	228	Target Neighborhood Hits	836	Shared Neighborhood Hits	7
SwissProt Accessions	Q99592, Q13397, Q5VU40, Q8N463	Gene names	ZNF238, RP58, TAZ1, ZBTB18
Domain Architecture
Description	Zinc finger protein 238 (Transcriptional repressor RP58) (58 kDa repressor protein) (Zinc finger protein C2H2-171) (Translin-associated zinc finger protein 1) (TAZ-1) (Zinc finger and BTB domain-containing protein 18).

ZN238_MOUSE
NC score	-0.004201 (rank : 375)	θ value	2.36792 (rank : 165)
Query Neighborhood Hits	228	Target Neighborhood Hits	837	Shared Neighborhood Hits	7
SwissProt Accessions	Q9WUK6	Gene names	Znf238, Rp58, Zfp238
Domain Architecture
Description	Zinc finger protein 238 (Zfp-238) (Transcriptional repressor RP58) (58 kDa repressor protein).

ZN516_HUMAN
NC score	-0.005499 (rank : 376)	θ value	6.88961 (rank : 212)
Query Neighborhood Hits	228	Target Neighborhood Hits	854	Shared Neighborhood Hits	11
SwissProt Accessions	Q92618	Gene names	ZNF516, KIAA0222
Domain Architecture	No domain graphic available
Description	Zinc finger protein 516.