Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : FGD1_HUMAN

For an explanation of this page, click here

FGD1_HUMAN
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

FGD1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	367	Target Neighborhood Hits	367	Shared Neighborhood Hits	367
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	0 (rank : 2)	NC score	0.984838 (rank : 2)
Query Neighborhood Hits	367	Target Neighborhood Hits	387	Shared Neighborhood Hits	248
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD4_MOUSE
θ value	0 (rank : 3)	NC score	0.954733 (rank : 6)
Query Neighborhood Hits	367	Target Neighborhood Hits	227	Shared Neighborhood Hits	142
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD4_HUMAN
θ value	1.0077e-184 (rank : 4)	NC score	0.954965 (rank : 5)
Query Neighborhood Hits	367	Target Neighborhood Hits	219	Shared Neighborhood Hits	137
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD3_HUMAN
θ value	5.01279e-176 (rank : 5)	NC score	0.947911 (rank : 7)
Query Neighborhood Hits	367	Target Neighborhood Hits	249	Shared Neighborhood Hits	130
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	1.72687e-168 (rank : 6)	NC score	0.945251 (rank : 8)
Query Neighborhood Hits	367	Target Neighborhood Hits	257	Shared Neighborhood Hits	134
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD2_MOUSE
θ value	1.04765e-165 (rank : 7)	NC score	0.957438 (rank : 3)
Query Neighborhood Hits	367	Target Neighborhood Hits	163	Shared Neighborhood Hits	130
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD2_HUMAN
θ value	1.12192e-159 (rank : 8)	NC score	0.957374 (rank : 4)
Query Neighborhood Hits	367	Target Neighborhood Hits	151	Shared Neighborhood Hits	128
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD6_MOUSE
θ value	7.70199e-76 (rank : 9)	NC score	0.888108 (rank : 9)
Query Neighborhood Hits	367	Target Neighborhood Hits	282	Shared Neighborhood Hits	131
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD6_HUMAN
θ value	4.22625e-74 (rank : 10)	NC score	0.884692 (rank : 10)
Query Neighborhood Hits	367	Target Neighborhood Hits	237	Shared Neighborhood Hits	118
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD5_HUMAN
θ value	3.36421e-55 (rank : 11)	NC score	0.827711 (rank : 11)
Query Neighborhood Hits	367	Target Neighborhood Hits	235	Shared Neighborhood Hits	112
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD5_MOUSE
θ value	1.46268e-50 (rank : 12)	NC score	0.815693 (rank : 12)
Query Neighborhood Hits	367	Target Neighborhood Hits	170	Shared Neighborhood Hits	103
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FARP2_MOUSE
θ value	2.19075e-38 (rank : 13)	NC score	0.574343 (rank : 31)
Query Neighborhood Hits	367	Target Neighborhood Hits	209	Shared Neighborhood Hits	96
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_HUMAN
θ value	8.32485e-38 (rank : 14)	NC score	0.558136 (rank : 36)
Query Neighborhood Hits	367	Target Neighborhood Hits	240	Shared Neighborhood Hits	101
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP1_HUMAN
θ value	4.72714e-33 (rank : 15)	NC score	0.528772 (rank : 41)
Query Neighborhood Hits	367	Target Neighborhood Hits	241	Shared Neighborhood Hits	94
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

PREX1_HUMAN
θ value	1.09232e-21 (rank : 16)	NC score	0.695196 (rank : 14)
Query Neighborhood Hits	367	Target Neighborhood Hits	177	Shared Neighborhood Hits	83
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

DUET_HUMAN
θ value	2.43343e-21 (rank : 17)	NC score	0.215759 (rank : 106)
Query Neighborhood Hits	367	Target Neighborhood Hits	1220	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

NGEF_HUMAN
θ value	3.88503e-19 (rank : 18)	NC score	0.633793 (rank : 18)
Query Neighborhood Hits	367	Target Neighborhood Hits	166	Shared Neighborhood Hits	74
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ECT2_MOUSE
θ value	5.07402e-19 (rank : 19)	NC score	0.698381 (rank : 13)
Query Neighborhood Hits	367	Target Neighborhood Hits	98	Shared Neighborhood Hits	72
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

NGEF_MOUSE
θ value	1.13037e-18 (rank : 20)	NC score	0.623099 (rank : 22)
Query Neighborhood Hits	367	Target Neighborhood Hits	228	Shared Neighborhood Hits	76
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ECT2_HUMAN
θ value	3.28887e-18 (rank : 21)	NC score	0.685618 (rank : 15)
Query Neighborhood Hits	367	Target Neighborhood Hits	98	Shared Neighborhood Hits	73
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHG4_HUMAN
θ value	8.10077e-17 (rank : 22)	NC score	0.612799 (rank : 24)
Query Neighborhood Hits	367	Target Neighborhood Hits	242	Shared Neighborhood Hits	77
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PKHF2_MOUSE
θ value	1.80466e-16 (rank : 23)	NC score	0.623435 (rank : 21)
Query Neighborhood Hits	367	Target Neighborhood Hits	77	Shared Neighborhood Hits	61
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHF2_HUMAN
θ value	2.35696e-16 (rank : 24)	NC score	0.623772 (rank : 19)
Query Neighborhood Hits	367	Target Neighborhood Hits	75	Shared Neighborhood Hits	61
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

TRIO_HUMAN
θ value	5.25075e-16 (rank : 25)	NC score	0.205796 (rank : 107)
Query Neighborhood Hits	367	Target Neighborhood Hits	1580	Shared Neighborhood Hits	124
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

ARHG5_HUMAN
θ value	3.40345e-15 (rank : 26)	NC score	0.643028 (rank : 16)
Query Neighborhood Hits	367	Target Neighborhood Hits	172	Shared Neighborhood Hits	70
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG4_MOUSE
θ value	4.91457e-14 (rank : 27)	NC score	0.622742 (rank : 23)
Query Neighborhood Hits	367	Target Neighborhood Hits	185	Shared Neighborhood Hits	76
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHGG_HUMAN
θ value	1.09485e-13 (rank : 28)	NC score	0.623624 (rank : 20)
Query Neighborhood Hits	367	Target Neighborhood Hits	129	Shared Neighborhood Hits	68
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG9_HUMAN
θ value	1.86753e-13 (rank : 29)	NC score	0.592309 (rank : 28)
Query Neighborhood Hits	367	Target Neighborhood Hits	235	Shared Neighborhood Hits	79
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHGF_HUMAN
θ value	1.86753e-13 (rank : 30)	NC score	0.591759 (rank : 29)
Query Neighborhood Hits	367	Target Neighborhood Hits	214	Shared Neighborhood Hits	108
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHG9_MOUSE
θ value	2.43908e-13 (rank : 31)	NC score	0.590632 (rank : 30)
Query Neighborhood Hits	367	Target Neighborhood Hits	234	Shared Neighborhood Hits	79
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

HAPIP_HUMAN
θ value	1.2105e-12 (rank : 32)	NC score	0.505164 (rank : 46)
Query Neighborhood Hits	367	Target Neighborhood Hits	350	Shared Neighborhood Hits	82
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ARHG7_HUMAN
θ value	2.69671e-12 (rank : 33)	NC score	0.441305 (rank : 61)
Query Neighborhood Hits	367	Target Neighborhood Hits	347	Shared Neighborhood Hits	85
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ZFY16_MOUSE
θ value	2.69671e-12 (rank : 34)	NC score	0.468496 (rank : 56)
Query Neighborhood Hits	367	Target Neighborhood Hits	108	Shared Neighborhood Hits	51
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

PKHF1_HUMAN
θ value	3.52202e-12 (rank : 35)	NC score	0.608290 (rank : 25)
Query Neighborhood Hits	367	Target Neighborhood Hits	76	Shared Neighborhood Hits	60
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

ARHGG_MOUSE
θ value	4.59992e-12 (rank : 36)	NC score	0.601700 (rank : 27)
Query Neighborhood Hits	367	Target Neighborhood Hits	152	Shared Neighborhood Hits	71
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ITSN1_HUMAN
θ value	4.59992e-12 (rank : 37)	NC score	0.375805 (rank : 77)
Query Neighborhood Hits	367	Target Neighborhood Hits	1757	Shared Neighborhood Hits	147
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

VAV_HUMAN
θ value	4.59992e-12 (rank : 38)	NC score	0.428347 (rank : 63)
Query Neighborhood Hits	367	Target Neighborhood Hits	452	Shared Neighborhood Hits	82
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

PKHF1_MOUSE
θ value	6.00763e-12 (rank : 39)	NC score	0.604669 (rank : 26)
Query Neighborhood Hits	367	Target Neighborhood Hits	80	Shared Neighborhood Hits	61
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

VAV_MOUSE
θ value	6.00763e-12 (rank : 40)	NC score	0.435416 (rank : 62)
Query Neighborhood Hits	367	Target Neighborhood Hits	430	Shared Neighborhood Hits	81
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

BCR_HUMAN
θ value	7.84624e-12 (rank : 41)	NC score	0.411898 (rank : 70)
Query Neighborhood Hits	367	Target Neighborhood Hits	204	Shared Neighborhood Hits	74
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ABR_HUMAN
θ value	1.74796e-11 (rank : 42)	NC score	0.410909 (rank : 71)
Query Neighborhood Hits	367	Target Neighborhood Hits	166	Shared Neighborhood Hits	67
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ZFYV9_HUMAN
θ value	1.74796e-11 (rank : 43)	NC score	0.480035 (rank : 54)
Query Neighborhood Hits	367	Target Neighborhood Hits	134	Shared Neighborhood Hits	51
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

ITSN1_MOUSE
θ value	2.28291e-11 (rank : 44)	NC score	0.375714 (rank : 78)
Query Neighborhood Hits	367	Target Neighborhood Hits	1669	Shared Neighborhood Hits	141
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ZFY16_HUMAN
θ value	5.08577e-11 (rank : 45)	NC score	0.458899 (rank : 58)
Query Neighborhood Hits	367	Target Neighborhood Hits	125	Shared Neighborhood Hits	50
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ARHGC_HUMAN
θ value	6.64225e-11 (rank : 46)	NC score	0.490425 (rank : 50)
Query Neighborhood Hits	367	Target Neighborhood Hits	351	Shared Neighborhood Hits	75
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHG2_MOUSE
θ value	8.67504e-11 (rank : 47)	NC score	0.560098 (rank : 34)
Query Neighborhood Hits	367	Target Neighborhood Hits	120	Shared Neighborhood Hits	66
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHGC_MOUSE
θ value	8.67504e-11 (rank : 48)	NC score	0.489087 (rank : 51)
Query Neighborhood Hits	367	Target Neighborhood Hits	344	Shared Neighborhood Hits	72
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ITSN2_MOUSE
θ value	8.67504e-11 (rank : 49)	NC score	0.381377 (rank : 76)
Query Neighborhood Hits	367	Target Neighborhood Hits	1371	Shared Neighborhood Hits	114
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

GNRP_MOUSE
θ value	1.133e-10 (rank : 50)	NC score	0.494212 (rank : 49)
Query Neighborhood Hits	367	Target Neighborhood Hits	191	Shared Neighborhood Hits	75
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

LBC_HUMAN
θ value	1.47974e-10 (rank : 51)	NC score	0.523024 (rank : 42)
Query Neighborhood Hits	367	Target Neighborhood Hits	90	Shared Neighborhood Hits	58
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHGB_HUMAN
θ value	1.9326e-10 (rank : 52)	NC score	0.514281 (rank : 44)
Query Neighborhood Hits	367	Target Neighborhood Hits	375	Shared Neighborhood Hits	85
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ITSN2_HUMAN
θ value	1.9326e-10 (rank : 53)	NC score	0.401641 (rank : 74)
Query Neighborhood Hits	367	Target Neighborhood Hits	1173	Shared Neighborhood Hits	112
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

PKHG1_HUMAN
θ value	3.29651e-10 (rank : 54)	NC score	0.641477 (rank : 17)
Query Neighborhood Hits	367	Target Neighborhood Hits	174	Shared Neighborhood Hits	74
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

VAV3_MOUSE
θ value	3.29651e-10 (rank : 55)	NC score	0.414129 (rank : 69)
Query Neighborhood Hits	367	Target Neighborhood Hits	404	Shared Neighborhood Hits	88
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

GNRP_HUMAN
θ value	5.62301e-10 (rank : 56)	NC score	0.463663 (rank : 57)
Query Neighborhood Hits	367	Target Neighborhood Hits	239	Shared Neighborhood Hits	78
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

ARHG7_MOUSE
θ value	1.25267e-09 (rank : 57)	NC score	0.420581 (rank : 65)
Query Neighborhood Hits	367	Target Neighborhood Hits	396	Shared Neighborhood Hits	81
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

TIAM1_HUMAN
θ value	1.25267e-09 (rank : 58)	NC score	0.535341 (rank : 38)
Query Neighborhood Hits	367	Target Neighborhood Hits	225	Shared Neighborhood Hits	77
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG2_HUMAN
θ value	1.63604e-09 (rank : 59)	NC score	0.507441 (rank : 45)
Query Neighborhood Hits	367	Target Neighborhood Hits	142	Shared Neighborhood Hits	68
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHGA_MOUSE
θ value	2.13673e-09 (rank : 60)	NC score	0.559648 (rank : 35)
Query Neighborhood Hits	367	Target Neighborhood Hits	125	Shared Neighborhood Hits	70
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_HUMAN
θ value	8.11959e-09 (rank : 61)	NC score	0.564241 (rank : 32)
Query Neighborhood Hits	367	Target Neighborhood Hits	187	Shared Neighborhood Hits	66
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

MCF2L_MOUSE
θ value	8.11959e-09 (rank : 62)	NC score	0.529783 (rank : 40)
Query Neighborhood Hits	367	Target Neighborhood Hits	255	Shared Neighborhood Hits	79
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

ARHG1_MOUSE
θ value	1.38499e-08 (rank : 63)	NC score	0.514783 (rank : 43)
Query Neighborhood Hits	367	Target Neighborhood Hits	266	Shared Neighborhood Hits	95
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

VAV3_HUMAN
θ value	1.38499e-08 (rank : 64)	NC score	0.410871 (rank : 72)
Query Neighborhood Hits	367	Target Neighborhood Hits	398	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

TIAM1_MOUSE
θ value	5.26297e-08 (rank : 65)	NC score	0.535634 (rank : 37)
Query Neighborhood Hits	367	Target Neighborhood Hits	205	Shared Neighborhood Hits	75
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ZFY28_HUMAN
θ value	5.26297e-08 (rank : 66)	NC score	0.484451 (rank : 53)
Query Neighborhood Hits	367	Target Neighborhood Hits	152	Shared Neighborhood Hits	60
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

RGNEF_MOUSE
θ value	6.87365e-08 (rank : 67)	NC score	0.408339 (rank : 73)
Query Neighborhood Hits	367	Target Neighborhood Hits	641	Shared Neighborhood Hits	88
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ARHG1_HUMAN
θ value	8.97725e-08 (rank : 68)	NC score	0.534173 (rank : 39)
Query Neighborhood Hits	367	Target Neighborhood Hits	176	Shared Neighborhood Hits	87
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

HGS_MOUSE
θ value	1.17247e-07 (rank : 69)	NC score	0.375270 (rank : 79)
Query Neighborhood Hits	367	Target Neighborhood Hits	589	Shared Neighborhood Hits	107
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

MCF2_HUMAN
θ value	1.17247e-07 (rank : 70)	NC score	0.560657 (rank : 33)
Query Neighborhood Hits	367	Target Neighborhood Hits	166	Shared Neighborhood Hits	74
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

HGS_HUMAN
θ value	1.99992e-07 (rank : 71)	NC score	0.372976 (rank : 80)
Query Neighborhood Hits	367	Target Neighborhood Hits	517	Shared Neighborhood Hits	93
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

RUFY1_MOUSE
θ value	1.99992e-07 (rank : 72)	NC score	0.260629 (rank : 98)
Query Neighborhood Hits	367	Target Neighborhood Hits	765	Shared Neighborhood Hits	77
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

EEA1_HUMAN
θ value	4.45536e-07 (rank : 73)	NC score	0.162091 (rank : 115)
Query Neighborhood Hits	367	Target Neighborhood Hits	1796	Shared Neighborhood Hits	98
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

EEA1_MOUSE
θ value	5.81887e-07 (rank : 74)	NC score	0.174803 (rank : 113)
Query Neighborhood Hits	367	Target Neighborhood Hits	1637	Shared Neighborhood Hits	99
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

RUFY1_HUMAN
θ value	5.81887e-07 (rank : 75)	NC score	0.256928 (rank : 99)
Query Neighborhood Hits	367	Target Neighborhood Hits	848	Shared Neighborhood Hits	81
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

RUFY2_HUMAN
θ value	5.81887e-07 (rank : 76)	NC score	0.218976 (rank : 104)
Query Neighborhood Hits	367	Target Neighborhood Hits	1208	Shared Neighborhood Hits	87
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

DNMBP_MOUSE
θ value	7.59969e-07 (rank : 77)	NC score	0.418095 (rank : 66)
Query Neighborhood Hits	367	Target Neighborhood Hits	435	Shared Neighborhood Hits	89
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

VAV2_HUMAN
θ value	7.59969e-07 (rank : 78)	NC score	0.415676 (rank : 67)
Query Neighborhood Hits	367	Target Neighborhood Hits	453	Shared Neighborhood Hits	95
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

PKHA6_HUMAN
θ value	9.92553e-07 (rank : 79)	NC score	0.219776 (rank : 103)
Query Neighborhood Hits	367	Target Neighborhood Hits	556	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

RUFY2_MOUSE
θ value	1.29631e-06 (rank : 80)	NC score	0.265160 (rank : 95)
Query Neighborhood Hits	367	Target Neighborhood Hits	820	Shared Neighborhood Hits	79
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

PKHA6_MOUSE
θ value	1.69304e-06 (rank : 81)	NC score	0.216399 (rank : 105)
Query Neighborhood Hits	367	Target Neighborhood Hits	591	Shared Neighborhood Hits	95
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

VAV2_MOUSE
θ value	1.69304e-06 (rank : 82)	NC score	0.421071 (rank : 64)
Query Neighborhood Hits	367	Target Neighborhood Hits	456	Shared Neighborhood Hits	100
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

WDFY3_HUMAN
θ value	3.77169e-06 (rank : 83)	NC score	0.260916 (rank : 96)
Query Neighborhood Hits	367	Target Neighborhood Hits	348	Shared Neighborhood Hits	57
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY3_MOUSE
θ value	3.77169e-06 (rank : 84)	NC score	0.260910 (rank : 97)
Query Neighborhood Hits	367	Target Neighborhood Hits	332	Shared Neighborhood Hits	56
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

DNMBP_HUMAN
θ value	1.09739e-05 (rank : 85)	NC score	0.398417 (rank : 75)
Query Neighborhood Hits	367	Target Neighborhood Hits	413	Shared Neighborhood Hits	91
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

WDFY1_HUMAN
θ value	1.43324e-05 (rank : 86)	NC score	0.276258 (rank : 94)
Query Neighborhood Hits	367	Target Neighborhood Hits	305	Shared Neighborhood Hits	49
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

SOS1_HUMAN
θ value	1.87187e-05 (rank : 87)	NC score	0.296791 (rank : 90)
Query Neighborhood Hits	367	Target Neighborhood Hits	274	Shared Neighborhood Hits	78
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS2_HUMAN
θ value	1.87187e-05 (rank : 88)	NC score	0.301433 (rank : 89)
Query Neighborhood Hits	367	Target Neighborhood Hits	193	Shared Neighborhood Hits	65
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

ANFY1_MOUSE
θ value	2.44474e-05 (rank : 89)	NC score	0.175006 (rank : 111)
Query Neighborhood Hits	367	Target Neighborhood Hits	480	Shared Neighborhood Hits	64
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_HUMAN
θ value	3.19293e-05 (rank : 90)	NC score	0.174871 (rank : 112)
Query Neighborhood Hits	367	Target Neighborhood Hits	480	Shared Neighborhood Hits	64
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

WDFY2_HUMAN
θ value	4.1701e-05 (rank : 91)	NC score	0.254078 (rank : 101)
Query Neighborhood Hits	367	Target Neighborhood Hits	332	Shared Neighborhood Hits	48
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

WDFY2_MOUSE
θ value	4.1701e-05 (rank : 92)	NC score	0.255791 (rank : 100)
Query Neighborhood Hits	367	Target Neighborhood Hits	337	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

ARHG3_HUMAN
θ value	5.44631e-05 (rank : 93)	NC score	0.497151 (rank : 48)
Query Neighborhood Hits	367	Target Neighborhood Hits	82	Shared Neighborhood Hits	64
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ZFY21_MOUSE
θ value	7.1131e-05 (rank : 94)	NC score	0.456304 (rank : 59)
Query Neighborhood Hits	367	Target Neighborhood Hits	72	Shared Neighborhood Hits	51
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ARHG3_MOUSE
θ value	9.29e-05 (rank : 95)	NC score	0.498052 (rank : 47)
Query Neighborhood Hits	367	Target Neighborhood Hits	85	Shared Neighborhood Hits	64
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

RGS3_MOUSE
θ value	0.000158464 (rank : 96)	NC score	0.083492 (rank : 145)
Query Neighborhood Hits	367	Target Neighborhood Hits	1621	Shared Neighborhood Hits	150
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

ZFY19_HUMAN
θ value	0.000270298 (rank : 97)	NC score	0.323342 (rank : 86)
Query Neighborhood Hits	367	Target Neighborhood Hits	206	Shared Neighborhood Hits	52
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

FYCO1_HUMAN
θ value	0.00035302 (rank : 98)	NC score	0.179868 (rank : 110)
Query Neighborhood Hits	367	Target Neighborhood Hits	1149	Shared Neighborhood Hits	88
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

RBNS5_HUMAN
θ value	0.00035302 (rank : 99)	NC score	0.348812 (rank : 82)
Query Neighborhood Hits	367	Target Neighborhood Hits	242	Shared Neighborhood Hits	69
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	0.000461057 (rank : 100)	NC score	0.339882 (rank : 83)
Query Neighborhood Hits	367	Target Neighborhood Hits	266	Shared Neighborhood Hits	61
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

DGKH_HUMAN
θ value	0.000602161 (rank : 101)	NC score	0.102543 (rank : 123)
Query Neighborhood Hits	367	Target Neighborhood Hits	255	Shared Neighborhood Hits	50
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

PKHG4_HUMAN
θ value	0.000602161 (rank : 102)	NC score	0.475028 (rank : 55)
Query Neighborhood Hits	367	Target Neighborhood Hits	200	Shared Neighborhood Hits	71
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

ZFY21_HUMAN
θ value	0.000602161 (rank : 103)	NC score	0.447561 (rank : 60)
Query Neighborhood Hits	367	Target Neighborhood Hits	72	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

MTMR3_HUMAN
θ value	0.000786445 (rank : 104)	NC score	0.242349 (rank : 102)
Query Neighborhood Hits	367	Target Neighborhood Hits	163	Shared Neighborhood Hits	58
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

SOS1_MOUSE
θ value	0.00102713 (rank : 105)	NC score	0.276676 (rank : 93)
Query Neighborhood Hits	367	Target Neighborhood Hits	281	Shared Neighborhood Hits	73
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOX13_MOUSE
θ value	0.00102713 (rank : 106)	NC score	0.044176 (rank : 335)
Query Neighborhood Hits	367	Target Neighborhood Hits	495	Shared Neighborhood Hits	52
SwissProt Accessions	Q04891, Q922L3	Gene names	Sox13, Sox-13
Domain Architecture
Description	SOX-13 protein.

FYCO1_MOUSE
θ value	0.00134147 (rank : 107)	NC score	0.164919 (rank : 114)
Query Neighborhood Hits	367	Target Neighborhood Hits	1059	Shared Neighborhood Hits	88
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

OBSCN_HUMAN
θ value	0.00175202 (rank : 108)	NC score	0.098222 (rank : 128)
Query Neighborhood Hits	367	Target Neighborhood Hits	1931	Shared Neighborhood Hits	133
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

ZFY19_MOUSE
θ value	0.00175202 (rank : 109)	NC score	0.314840 (rank : 88)
Query Neighborhood Hits	367	Target Neighborhood Hits	143	Shared Neighborhood Hits	55
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

K1802_MOUSE
θ value	0.00228821 (rank : 110)	NC score	0.049460 (rank : 315)
Query Neighborhood Hits	367	Target Neighborhood Hits	1596	Shared Neighborhood Hits	122
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

DGKD_HUMAN
θ value	0.00298849 (rank : 111)	NC score	0.082320 (rank : 149)
Query Neighborhood Hits	367	Target Neighborhood Hits	231	Shared Neighborhood Hits	35
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

NCOA6_HUMAN
θ value	0.00298849 (rank : 112)	NC score	0.079093 (rank : 162)
Query Neighborhood Hits	367	Target Neighborhood Hits	1202	Shared Neighborhood Hits	133
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

RGS3_HUMAN
θ value	0.00298849 (rank : 113)	NC score	0.060499 (rank : 238)
Query Neighborhood Hits	367	Target Neighborhood Hits	1375	Shared Neighborhood Hits	134
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

SEPT9_HUMAN
θ value	0.00298849 (rank : 114)	NC score	0.028414 (rank : 384)
Query Neighborhood Hits	367	Target Neighborhood Hits	706	Shared Neighborhood Hits	64
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

ZFYV1_HUMAN
θ value	0.00390308 (rank : 115)	NC score	0.332326 (rank : 84)
Query Neighborhood Hits	367	Target Neighborhood Hits	166	Shared Neighborhood Hits	55
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

TCGAP_HUMAN
θ value	0.00509761 (rank : 116)	NC score	0.086431 (rank : 140)
Query Neighborhood Hits	367	Target Neighborhood Hits	872	Shared Neighborhood Hits	111
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ZFYV1_MOUSE
θ value	0.00665767 (rank : 117)	NC score	0.328665 (rank : 85)
Query Neighborhood Hits	367	Target Neighborhood Hits	153	Shared Neighborhood Hits	54
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

CENB5_HUMAN
θ value	0.00869519 (rank : 118)	NC score	0.068676 (rank : 190)
Query Neighborhood Hits	367	Target Neighborhood Hits	395	Shared Neighborhood Hits	44
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

MDC1_MOUSE
θ value	0.00869519 (rank : 119)	NC score	0.051965 (rank : 297)
Query Neighborhood Hits	367	Target Neighborhood Hits	998	Shared Neighborhood Hits	90
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

DIDO1_HUMAN
θ value	0.0113563 (rank : 120)	NC score	0.061250 (rank : 234)
Query Neighborhood Hits	367	Target Neighborhood Hits	960	Shared Neighborhood Hits	103
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

SPR1B_MOUSE
θ value	0.0113563 (rank : 121)	NC score	0.052816 (rank : 289)
Query Neighborhood Hits	367	Target Neighborhood Hits	395	Shared Neighborhood Hits	50
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

ARRD2_HUMAN
θ value	0.0148317 (rank : 122)	NC score	0.038723 (rank : 348)
Query Neighborhood Hits	367	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TBH0, O95895, Q6ZRV9, Q8WYG6	Gene names	ARRDC2
Domain Architecture	No domain graphic available
Description	Arrestin domain-containing protein 2.

FYV1_HUMAN
θ value	0.0148317 (rank : 123)	NC score	0.287545 (rank : 91)
Query Neighborhood Hits	367	Target Neighborhood Hits	217	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	0.0148317 (rank : 124)	NC score	0.284492 (rank : 92)
Query Neighborhood Hits	367	Target Neighborhood Hits	191	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

SON_HUMAN
θ value	0.0148317 (rank : 125)	NC score	0.062715 (rank : 221)
Query Neighborhood Hits	367	Target Neighborhood Hits	1568	Shared Neighborhood Hits	149
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

CO6A2_MOUSE
θ value	0.0193708 (rank : 126)	NC score	0.044959 (rank : 333)
Query Neighborhood Hits	367	Target Neighborhood Hits	260	Shared Neighborhood Hits	48
SwissProt Accessions	Q02788, Q05505	Gene names	Col6a2
Domain Architecture
Description	Collagen alpha-2(VI) chain precursor.

OGFR_HUMAN
θ value	0.0193708 (rank : 127)	NC score	0.077978 (rank : 165)
Query Neighborhood Hits	367	Target Neighborhood Hits	1582	Shared Neighborhood Hits	141
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

OSBL9_HUMAN
θ value	0.0193708 (rank : 128)	NC score	0.079655 (rank : 160)
Query Neighborhood Hits	367	Target Neighborhood Hits	138	Shared Neighborhood Hits	29
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

PKHA4_HUMAN
θ value	0.0193708 (rank : 129)	NC score	0.160238 (rank : 116)
Query Neighborhood Hits	367	Target Neighborhood Hits	283	Shared Neighborhood Hits	75
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_MOUSE
θ value	0.0252991 (rank : 130)	NC score	0.154671 (rank : 117)
Query Neighborhood Hits	367	Target Neighborhood Hits	202	Shared Neighborhood Hits	47
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

CO7A1_HUMAN
θ value	0.0330416 (rank : 131)	NC score	0.032187 (rank : 372)
Query Neighborhood Hits	367	Target Neighborhood Hits	807	Shared Neighborhood Hits	81
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

CENB2_HUMAN
θ value	0.0431538 (rank : 132)	NC score	0.066272 (rank : 206)
Query Neighborhood Hits	367	Target Neighborhood Hits	425	Shared Neighborhood Hits	44
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

MLL3_HUMAN
θ value	0.0431538 (rank : 133)	NC score	0.048725 (rank : 316)
Query Neighborhood Hits	367	Target Neighborhood Hits	1644	Shared Neighborhood Hits	132
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

ARHG8_HUMAN
θ value	0.0563607 (rank : 134)	NC score	0.487819 (rank : 52)
Query Neighborhood Hits	367	Target Neighborhood Hits	85	Shared Neighborhood Hits	72
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

MINT_MOUSE
θ value	0.0563607 (rank : 135)	NC score	0.046633 (rank : 328)
Query Neighborhood Hits	367	Target Neighborhood Hits	1514	Shared Neighborhood Hits	114
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

SWP70_HUMAN
θ value	0.0563607 (rank : 136)	NC score	0.095276 (rank : 130)
Query Neighborhood Hits	367	Target Neighborhood Hits	973	Shared Neighborhood Hits	64
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

TXND2_HUMAN
θ value	0.0563607 (rank : 137)	NC score	0.039728 (rank : 347)
Query Neighborhood Hits	367	Target Neighborhood Hits	793	Shared Neighborhood Hits	67
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

BAG3_MOUSE
θ value	0.0736092 (rank : 138)	NC score	0.050199 (rank : 309)
Query Neighborhood Hits	367	Target Neighborhood Hits	513	Shared Neighborhood Hits	81
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

LCP2_HUMAN
θ value	0.0736092 (rank : 139)	NC score	0.052492 (rank : 293)
Query Neighborhood Hits	367	Target Neighborhood Hits	531	Shared Neighborhood Hits	78
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

RFIP3_HUMAN
θ value	0.0736092 (rank : 140)	NC score	0.056431 (rank : 268)
Query Neighborhood Hits	367	Target Neighborhood Hits	1055	Shared Neighborhood Hits	77
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

SWP70_MOUSE
θ value	0.0736092 (rank : 141)	NC score	0.092160 (rank : 133)
Query Neighborhood Hits	367	Target Neighborhood Hits	1097	Shared Neighborhood Hits	69
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

WASIP_MOUSE
θ value	0.0736092 (rank : 142)	NC score	0.090213 (rank : 136)
Query Neighborhood Hits	367	Target Neighborhood Hits	392	Shared Neighborhood Hits	97
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

CENB1_HUMAN
θ value	0.0961366 (rank : 143)	NC score	0.055706 (rank : 274)
Query Neighborhood Hits	367	Target Neighborhood Hits	383	Shared Neighborhood Hits	43
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

CNTRB_MOUSE
θ value	0.0961366 (rank : 144)	NC score	0.043007 (rank : 338)
Query Neighborhood Hits	367	Target Neighborhood Hits	1029	Shared Neighborhood Hits	53
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

CO6A2_HUMAN
θ value	0.0961366 (rank : 145)	NC score	0.044336 (rank : 334)
Query Neighborhood Hits	367	Target Neighborhood Hits	249	Shared Neighborhood Hits	50
SwissProt Accessions	P12110, Q13909, Q13910, Q13911, Q14049, Q16259, Q16597, Q9UML3	Gene names	COL6A2
Domain Architecture
Description	Collagen alpha-2(VI) chain precursor.

STAT2_MOUSE
θ value	0.0961366 (rank : 146)	NC score	0.020331 (rank : 410)
Query Neighborhood Hits	367	Target Neighborhood Hits	175	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WVL2, Q64188, Q64189, Q64250	Gene names	Stat2
Domain Architecture
Description	Signal transducer and activator of transcription 2.

ZFY27_MOUSE
θ value	0.0961366 (rank : 147)	NC score	0.196780 (rank : 108)
Query Neighborhood Hits	367	Target Neighborhood Hits	53	Shared Neighborhood Hits	42
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

PKHA5_HUMAN
θ value	0.163984 (rank : 148)	NC score	0.142190 (rank : 118)
Query Neighborhood Hits	367	Target Neighborhood Hits	455	Shared Neighborhood Hits	52
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

SYTL3_MOUSE
θ value	0.163984 (rank : 149)	NC score	0.041222 (rank : 341)
Query Neighborhood Hits	367	Target Neighborhood Hits	110	Shared Neighborhood Hits	19
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

SYTL4_HUMAN
θ value	0.163984 (rank : 150)	NC score	0.053090 (rank : 287)
Query Neighborhood Hits	367	Target Neighborhood Hits	138	Shared Neighborhood Hits	27
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

TARSH_HUMAN
θ value	0.163984 (rank : 151)	NC score	0.070600 (rank : 186)
Query Neighborhood Hits	367	Target Neighborhood Hits	768	Shared Neighborhood Hits	87
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

ZN185_HUMAN
θ value	0.163984 (rank : 152)	NC score	0.029578 (rank : 382)
Query Neighborhood Hits	367	Target Neighborhood Hits	112	Shared Neighborhood Hits	13
SwissProt Accessions	O15231, O00345, Q9NSD2	Gene names	ZNF185
Domain Architecture
Description	Zinc finger protein 185 (LIM-domain protein ZNF185) (P1-A).

ADA12_MOUSE
θ value	0.21417 (rank : 153)	NC score	0.011760 (rank : 452)
Query Neighborhood Hits	367	Target Neighborhood Hits	474	Shared Neighborhood Hits	41
SwissProt Accessions	Q61824	Gene names	Adam12, Mltna
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

ALS2_MOUSE
θ value	0.21417 (rank : 154)	NC score	0.123219 (rank : 119)
Query Neighborhood Hits	367	Target Neighborhood Hits	111	Shared Neighborhood Hits	26
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

BSN_HUMAN
θ value	0.21417 (rank : 155)	NC score	0.079410 (rank : 161)
Query Neighborhood Hits	367	Target Neighborhood Hits	1537	Shared Neighborhood Hits	150
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

DGKK_HUMAN
θ value	0.21417 (rank : 156)	NC score	0.096455 (rank : 129)
Query Neighborhood Hits	367	Target Neighborhood Hits	378	Shared Neighborhood Hits	85
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

FLNA_HUMAN
θ value	0.21417 (rank : 157)	NC score	0.026583 (rank : 390)
Query Neighborhood Hits	367	Target Neighborhood Hits	138	Shared Neighborhood Hits	12
SwissProt Accessions	P21333	Gene names	FLNA, FLN, FLN1
Domain Architecture
Description	Filamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin).

NACAM_MOUSE
θ value	0.21417 (rank : 158)	NC score	0.061891 (rank : 230)
Query Neighborhood Hits	367	Target Neighborhood Hits	1866	Shared Neighborhood Hits	138
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

NCOA3_MOUSE
θ value	0.21417 (rank : 159)	NC score	0.021006 (rank : 408)
Query Neighborhood Hits	367	Target Neighborhood Hits	203	Shared Neighborhood Hits	34
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

ZIMP7_MOUSE
θ value	0.21417 (rank : 160)	NC score	0.046601 (rank : 329)
Query Neighborhood Hits	367	Target Neighborhood Hits	566	Shared Neighborhood Hits	75
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

BCAR1_MOUSE
θ value	0.279714 (rank : 161)	NC score	0.080449 (rank : 157)
Query Neighborhood Hits	367	Target Neighborhood Hits	438	Shared Neighborhood Hits	77
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

COHA1_HUMAN
θ value	0.279714 (rank : 162)	NC score	0.044154 (rank : 336)
Query Neighborhood Hits	367	Target Neighborhood Hits	400	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UMD9, Q02802, Q99018, Q9NQK9, Q9UC14	Gene names	COL17A1, BP180, BPAG2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

CSPG3_HUMAN
θ value	0.279714 (rank : 163)	NC score	0.014890 (rank : 438)
Query Neighborhood Hits	367	Target Neighborhood Hits	676	Shared Neighborhood Hits	41
SwissProt Accessions	O14594, Q9UPK6	Gene names	CSPG3, NCAN, NEUR
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

FLNA_MOUSE
θ value	0.279714 (rank : 164)	NC score	0.026396 (rank : 392)
Query Neighborhood Hits	367	Target Neighborhood Hits	142	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BTM8, O54934, Q7TQI1, Q8BLK1, Q8BTN7, Q8VHX5, Q8VHX8, Q99KQ2	Gene names	Flna, Fln, Fln1
Domain Architecture
Description	Filamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin).

MILK1_HUMAN
θ value	0.279714 (rank : 165)	NC score	0.046571 (rank : 330)
Query Neighborhood Hits	367	Target Neighborhood Hits	427	Shared Neighborhood Hits	79
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

MYO15_HUMAN
θ value	0.279714 (rank : 166)	NC score	0.018243 (rank : 416)
Query Neighborhood Hits	367	Target Neighborhood Hits	671	Shared Neighborhood Hits	97
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

PCLO_MOUSE
θ value	0.279714 (rank : 167)	NC score	0.066275 (rank : 205)
Query Neighborhood Hits	367	Target Neighborhood Hits	2275	Shared Neighborhood Hits	182
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PI5PA_HUMAN
θ value	0.279714 (rank : 168)	NC score	0.047460 (rank : 322)
Query Neighborhood Hits	367	Target Neighborhood Hits	749	Shared Neighborhood Hits	95
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

PRRT3_HUMAN
θ value	0.279714 (rank : 169)	NC score	0.066698 (rank : 201)
Query Neighborhood Hits	367	Target Neighborhood Hits	998	Shared Neighborhood Hits	121
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

SPTN4_HUMAN
θ value	0.279714 (rank : 170)	NC score	0.041025 (rank : 342)
Query Neighborhood Hits	367	Target Neighborhood Hits	570	Shared Neighborhood Hits	62
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

WASF1_MOUSE
θ value	0.279714 (rank : 171)	NC score	0.046884 (rank : 325)
Query Neighborhood Hits	367	Target Neighborhood Hits	261	Shared Neighborhood Hits	75
SwissProt Accessions	Q8R5H6, Q91W51, Q9ERQ9	Gene names	Wasf1, Wave1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1).

ASPP1_MOUSE
θ value	0.365318 (rank : 172)	NC score	0.072555 (rank : 179)
Query Neighborhood Hits	367	Target Neighborhood Hits	1244	Shared Neighborhood Hits	122
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

CENG1_MOUSE
θ value	0.365318 (rank : 173)	NC score	0.033517 (rank : 367)
Query Neighborhood Hits	367	Target Neighborhood Hits	531	Shared Neighborhood Hits	46
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

CO4A5_HUMAN
θ value	0.365318 (rank : 174)	NC score	0.047833 (rank : 319)
Query Neighborhood Hits	367	Target Neighborhood Hits	383	Shared Neighborhood Hits	70
SwissProt Accessions	P29400, Q16006, Q16126, Q6LD84	Gene names	COL4A5
Domain Architecture
Description	Collagen alpha-5(IV) chain precursor.

EFS_MOUSE
θ value	0.365318 (rank : 175)	NC score	0.080932 (rank : 154)
Query Neighborhood Hits	367	Target Neighborhood Hits	389	Shared Neighborhood Hits	55
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

KS6A4_MOUSE
θ value	0.365318 (rank : 176)	NC score	0.001777 (rank : 494)
Query Neighborhood Hits	367	Target Neighborhood Hits	866	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

MELPH_HUMAN
θ value	0.365318 (rank : 177)	NC score	0.076431 (rank : 171)
Query Neighborhood Hits	367	Target Neighborhood Hits	145	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BV36, Q9HA71	Gene names	MLPH, SLAC2A
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Synaptotagmin-like protein 2a) (Slp homolog lacking C2 domains a).

NHLC1_MOUSE
θ value	0.365318 (rank : 178)	NC score	0.063546 (rank : 218)
Query Neighborhood Hits	367	Target Neighborhood Hits	103	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BR37	Gene names	Nhlrc1, Epm2b
Domain Architecture	No domain graphic available
Description	NHL repeat-containing protein 1 (Malin).

SEM6A_HUMAN
θ value	0.365318 (rank : 179)	NC score	0.016765 (rank : 425)
Query Neighborhood Hits	367	Target Neighborhood Hits	96	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H2E6, Q9P2H9	Gene names	SEMA6A, KIAA1368
Domain Architecture
Description	Semaphorin-6A precursor (Semaphorin VIA) (Sema VIA) (Semaphorin 6A-1) (SEMA6A-1).

SEM6A_MOUSE
θ value	0.365318 (rank : 180)	NC score	0.016531 (rank : 428)
Query Neighborhood Hits	367	Target Neighborhood Hits	96	Shared Neighborhood Hits	10
SwissProt Accessions	O35464, Q6P5A8, Q6PCN9, Q9EQ71	Gene names	Sema6a, Semaq
Domain Architecture
Description	Semaphorin-6A precursor (Semaphorin VIA) (Sema VIA) (Semaphorin 6A-1) (SEMA6A-1) (Semaphorin Q) (Sema Q).

3BP2_HUMAN
θ value	0.47712 (rank : 181)	NC score	0.092333 (rank : 132)
Query Neighborhood Hits	367	Target Neighborhood Hits	296	Shared Neighborhood Hits	56
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

CO5A1_MOUSE
θ value	0.47712 (rank : 182)	NC score	0.047519 (rank : 321)
Query Neighborhood Hits	367	Target Neighborhood Hits	419	Shared Neighborhood Hits	82
SwissProt Accessions	O88207	Gene names	Col5a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(V) chain precursor.

ETV5_MOUSE
θ value	0.47712 (rank : 183)	NC score	0.014015 (rank : 443)
Query Neighborhood Hits	367	Target Neighborhood Hits	328	Shared Neighborhood Hits	45
SwissProt Accessions	Q9CXC9, Q3TG49, Q8C0F3, Q9JHB1	Gene names	Etv5
Domain Architecture	No domain graphic available
Description	ETS translocation variant 5.

MELPH_MOUSE
θ value	0.47712 (rank : 184)	NC score	0.090728 (rank : 135)
Query Neighborhood Hits	367	Target Neighborhood Hits	112	Shared Neighborhood Hits	22
SwissProt Accessions	Q91V27, Q99N53	Gene names	Mlph, Ln, Slac2a
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Leaden protein) (Synaptotagmin-like protein 2a) (Slac2-a) (Slp homolog lacking C2 domains a).

MYT1L_MOUSE
θ value	0.47712 (rank : 185)	NC score	0.020863 (rank : 409)
Query Neighborhood Hits	367	Target Neighborhood Hits	461	Shared Neighborhood Hits	24
SwissProt Accessions	P97500, O08996, Q8C643, Q8C7L4, Q8CHB4	Gene names	Myt1l, Kiaa1106, Nzf1, Png1
Domain Architecture	No domain graphic available
Description	Myelin transcription factor 1-like protein (MyT1L protein) (Postmitotic neural gene 1 protein) (Zinc finger protein Png-1) (Neural zinc finger factor 1) (NZF-1).

PCLO_HUMAN
θ value	0.47712 (rank : 186)	NC score	0.072873 (rank : 178)
Query Neighborhood Hits	367	Target Neighborhood Hits	2046	Shared Neighborhood Hits	172
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

RIMB1_HUMAN
θ value	0.47712 (rank : 187)	NC score	0.062177 (rank : 226)
Query Neighborhood Hits	367	Target Neighborhood Hits	1479	Shared Neighborhood Hits	118
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SETBP_HUMAN
θ value	0.47712 (rank : 188)	NC score	0.036587 (rank : 356)
Query Neighborhood Hits	367	Target Neighborhood Hits	305	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y6X0, Q9UEF3	Gene names	SETBP1, KIAA0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

ZFY27_HUMAN
θ value	0.47712 (rank : 189)	NC score	0.187376 (rank : 109)
Query Neighborhood Hits	367	Target Neighborhood Hits	64	Shared Neighborhood Hits	42
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

CEND1_HUMAN
θ value	0.62314 (rank : 190)	NC score	0.058577 (rank : 251)
Query Neighborhood Hits	367	Target Neighborhood Hits	284	Shared Neighborhood Hits	47
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CENG1_HUMAN
θ value	0.62314 (rank : 191)	NC score	0.031381 (rank : 377)
Query Neighborhood Hits	367	Target Neighborhood Hits	544	Shared Neighborhood Hits	45
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

FA47B_HUMAN
θ value	0.62314 (rank : 192)	NC score	0.048673 (rank : 317)
Query Neighborhood Hits	367	Target Neighborhood Hits	431	Shared Neighborhood Hits	65
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

GA2L2_MOUSE
θ value	0.62314 (rank : 193)	NC score	0.030006 (rank : 379)
Query Neighborhood Hits	367	Target Neighborhood Hits	395	Shared Neighborhood Hits	52
SwissProt Accessions	Q5SSG4	Gene names	Gas2l2
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2).

MYRIP_MOUSE
θ value	0.62314 (rank : 194)	NC score	0.081843 (rank : 150)
Query Neighborhood Hits	367	Target Neighborhood Hits	207	Shared Neighborhood Hits	30
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

NHLC1_HUMAN
θ value	0.62314 (rank : 195)	NC score	0.053264 (rank : 285)
Query Neighborhood Hits	367	Target Neighborhood Hits	91	Shared Neighborhood Hits	10
SwissProt Accessions	Q6VVB1, Q6IMH1	Gene names	NHLRC1, EPM2B
Domain Architecture	No domain graphic available
Description	NHL repeat-containing protein 1 (Malin).

WASF1_HUMAN
θ value	0.62314 (rank : 196)	NC score	0.044143 (rank : 337)
Query Neighborhood Hits	367	Target Neighborhood Hits	260	Shared Neighborhood Hits	71
SwissProt Accessions	Q92558	Gene names	WASF1, KIAA0269, SCAR1, WAVE1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1).

APXL_HUMAN
θ value	0.813845 (rank : 197)	NC score	0.036738 (rank : 354)
Query Neighborhood Hits	367	Target Neighborhood Hits	553	Shared Neighborhood Hits	64
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

CCD45_MOUSE
θ value	0.813845 (rank : 198)	NC score	0.035594 (rank : 363)
Query Neighborhood Hits	367	Target Neighborhood Hits	663	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BVV7	Gene names	Ccdc45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

CO4A2_HUMAN
θ value	0.813845 (rank : 199)	NC score	0.036676 (rank : 355)
Query Neighborhood Hits	367	Target Neighborhood Hits	454	Shared Neighborhood Hits	67
SwissProt Accessions	P08572	Gene names	COL4A2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

CO5A1_HUMAN
θ value	0.813845 (rank : 200)	NC score	0.045749 (rank : 331)
Query Neighborhood Hits	367	Target Neighborhood Hits	434	Shared Neighborhood Hits	76
SwissProt Accessions	P20908, Q15094, Q5SUX4	Gene names	COL5A1
Domain Architecture
Description	Collagen alpha-1(V) chain precursor.

CRSP7_HUMAN
θ value	0.813845 (rank : 201)	NC score	0.042058 (rank : 340)
Query Neighborhood Hits	367	Target Neighborhood Hits	247	Shared Neighborhood Hits	42
SwissProt Accessions	O95402	Gene names	CRSP7, ARC70
Domain Architecture
Description	CRSP complex subunit 7 (Cofactor required for Sp1 transcriptional activation subunit 7) (Transcriptional coactivator CRSP70) (Activator- recruited cofactor 70 kDa component) (ARC70).

EMID2_HUMAN
θ value	0.813845 (rank : 202)	NC score	0.037058 (rank : 351)
Query Neighborhood Hits	367	Target Neighborhood Hits	226	Shared Neighborhood Hits	59
SwissProt Accessions	Q96A83	Gene names	EMID2, COL26A1, EMU2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXVI) chain precursor (EMI domain-containing protein 2) (Protein Emu2) (Emilin and multimerin domain-containing protein 2).

FHL5_MOUSE
θ value	0.813845 (rank : 203)	NC score	0.007289 (rank : 468)
Query Neighborhood Hits	367	Target Neighborhood Hits	463	Shared Neighborhood Hits	8
SwissProt Accessions	Q9WTX7	Gene names	Fhl5, Act
Domain Architecture	No domain graphic available
Description	Four and a half LIM domains protein 5 (FHL-5) (Activator of cAMP- responsive element modulator in testis) (Activator of CREM in testis).

FLNC_HUMAN
θ value	0.813845 (rank : 204)	NC score	0.028891 (rank : 383)
Query Neighborhood Hits	367	Target Neighborhood Hits	116	Shared Neighborhood Hits	16
SwissProt Accessions	Q14315, O95303, Q07985, Q9NS12, Q9NYE5, Q9UMR8, Q9Y503	Gene names	FLNC, ABPL, FLN2
Domain Architecture
Description	Filamin-C (Gamma-filamin) (Filamin-2) (Protein FLNc) (Actin-binding- like protein) (ABP-L) (ABP-280-like protein).

NCOA6_MOUSE
θ value	0.813845 (rank : 205)	NC score	0.064353 (rank : 215)
Query Neighborhood Hits	367	Target Neighborhood Hits	1076	Shared Neighborhood Hits	119
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

NOTC3_HUMAN
θ value	0.813845 (rank : 206)	NC score	0.006086 (rank : 471)
Query Neighborhood Hits	367	Target Neighborhood Hits	1062	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

SOX13_HUMAN
θ value	0.813845 (rank : 207)	NC score	0.031598 (rank : 375)
Query Neighborhood Hits	367	Target Neighborhood Hits	464	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UN79, O95275, O95826, Q9UHW7	Gene names	SOX13
Domain Architecture
Description	SOX-13 protein (Type 1 diabetes autoantigen ICA12) (Islet cell antigen 12).

SPR1A_MOUSE
θ value	0.813845 (rank : 208)	NC score	0.040327 (rank : 344)
Query Neighborhood Hits	367	Target Neighborhood Hits	343	Shared Neighborhood Hits	43
SwissProt Accessions	Q62266	Gene names	Sprr1a
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein 1A) (SPR1A) (SPR1 A).

WASIP_HUMAN
θ value	0.813845 (rank : 209)	NC score	0.088217 (rank : 138)
Query Neighborhood Hits	367	Target Neighborhood Hits	458	Shared Neighborhood Hits	105
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

ZBT7A_HUMAN
θ value	0.813845 (rank : 210)	NC score	-0.006838 (rank : 504)
Query Neighborhood Hits	367	Target Neighborhood Hits	823	Shared Neighborhood Hits	14
SwissProt Accessions	O95365, O00456	Gene names	ZBTB7A, FBI1, LRF, ZBTB7
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 7A (Leukemia/lymphoma- related factor) (Factor that binds to inducer of short transcripts protein 1) (Factor binding IST protein 1) (FBI-1) (HIV-1 1st-binding protein 1) (TTF-I-interacting peptide 21) (TIP21).

ZN516_MOUSE
θ value	0.813845 (rank : 211)	NC score	0.002542 (rank : 490)
Query Neighborhood Hits	367	Target Neighborhood Hits	1197	Shared Neighborhood Hits	84
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

BCAR1_HUMAN
θ value	1.06291 (rank : 212)	NC score	0.080493 (rank : 156)
Query Neighborhood Hits	367	Target Neighborhood Hits	554	Shared Neighborhood Hits	90
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

GAK7_HUMAN
θ value	1.06291 (rank : 213)	NC score	0.018203 (rank : 417)
Query Neighborhood Hits	367	Target Neighborhood Hits	90	Shared Neighborhood Hits	21
SwissProt Accessions	Q96PI4, Q9QC08	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q23.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K18 Gag protein) (HERV-K110 Gag protein) (HERV-K(C1a) Gag protein) [Contains: Matrix protein].

IASPP_MOUSE
θ value	1.06291 (rank : 214)	NC score	0.074435 (rank : 173)
Query Neighborhood Hits	367	Target Neighborhood Hits	1024	Shared Neighborhood Hits	129
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

KIF1A_MOUSE
θ value	1.06291 (rank : 215)	NC score	0.017000 (rank : 423)
Query Neighborhood Hits	367	Target Neighborhood Hits	239	Shared Neighborhood Hits	22
SwissProt Accessions	P33173, Q61770	Gene names	Kif1a, Atsv, Kif1
Domain Architecture
Description	Kinesin-like protein KIF1A (Axonal transporter of synaptic vesicles).

PHC1_MOUSE
θ value	1.06291 (rank : 216)	NC score	0.031462 (rank : 376)
Query Neighborhood Hits	367	Target Neighborhood Hits	205	Shared Neighborhood Hits	31
SwissProt Accessions	Q64028, P70359, Q64307, Q8BZ80	Gene names	Phc1, Edr, Edr1, Rae28
Domain Architecture
Description	Polyhomeotic-like protein 1 (mPH1) (Early development regulatory protein 1) (RAE-28).

SYTL4_MOUSE
θ value	1.06291 (rank : 217)	NC score	0.040217 (rank : 345)
Query Neighborhood Hits	367	Target Neighborhood Hits	137	Shared Neighborhood Hits	24
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

B4GN4_MOUSE
θ value	1.38821 (rank : 218)	NC score	0.016015 (rank : 430)
Query Neighborhood Hits	367	Target Neighborhood Hits	129	Shared Neighborhood Hits	17
SwissProt Accessions	Q766D5, Q8CHV2	Gene names	B4galnt4
Domain Architecture	No domain graphic available
Description	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferase 1 (EC 2.4.1.244) (NGalNAc-T1) (Beta- 1,4-N-acetylgalactosaminyltransferase IV) (Beta4GalNAc-T4) (Beta4GalNAcT4).

BSN_MOUSE
θ value	1.38821 (rank : 219)	NC score	0.077319 (rank : 169)
Query Neighborhood Hits	367	Target Neighborhood Hits	2057	Shared Neighborhood Hits	173
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CO3A1_MOUSE
θ value	1.38821 (rank : 220)	NC score	0.045558 (rank : 332)
Query Neighborhood Hits	367	Target Neighborhood Hits	466	Shared Neighborhood Hits	73
SwissProt Accessions	P08121, Q61429, Q9CRN7	Gene names	Col3a1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

CS007_MOUSE
θ value	1.38821 (rank : 221)	NC score	0.035468 (rank : 364)
Query Neighborhood Hits	367	Target Neighborhood Hits	464	Shared Neighborhood Hits	77
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

GAB1_MOUSE
θ value	1.38821 (rank : 222)	NC score	0.022195 (rank : 405)
Query Neighborhood Hits	367	Target Neighborhood Hits	233	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GAK6_HUMAN
θ value	1.38821 (rank : 223)	NC score	0.018533 (rank : 414)
Query Neighborhood Hits	367	Target Neighborhood Hits	392	Shared Neighborhood Hits	46
SwissProt Accessions	P62685	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_8p23.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K115 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GP153_HUMAN
θ value	1.38821 (rank : 224)	NC score	0.015576 (rank : 434)
Query Neighborhood Hits	367	Target Neighborhood Hits	332	Shared Neighborhood Hits	19
SwissProt Accessions	Q6NV75, Q5TGR5, Q6AHW8, Q86SP8	Gene names	GPR153, PGR1
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 153 (G-protein coupled receptor PGR1).

KIF1A_HUMAN
θ value	1.38821 (rank : 225)	NC score	0.016067 (rank : 429)
Query Neighborhood Hits	367	Target Neighborhood Hits	240	Shared Neighborhood Hits	22
SwissProt Accessions	Q12756	Gene names	KIF1A, ATSV
Domain Architecture
Description	Kinesin-like protein KIF1A (Axonal transporter of synaptic vesicles).

NSD1_MOUSE
θ value	1.38821 (rank : 226)	NC score	0.026152 (rank : 393)
Query Neighborhood Hits	367	Target Neighborhood Hits	472	Shared Neighborhood Hits	45
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

OGFR_MOUSE
θ value	1.38821 (rank : 227)	NC score	0.050339 (rank : 308)
Query Neighborhood Hits	367	Target Neighborhood Hits	584	Shared Neighborhood Hits	68
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

PCID2_MOUSE
θ value	1.38821 (rank : 228)	NC score	0.030800 (rank : 378)
Query Neighborhood Hits	367	Target Neighborhood Hits	5	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BFV2, Q8C951	Gene names	Pcid2
Domain Architecture	No domain graphic available
Description	PCI domain-containing protein 2 (CSN12-like protein).

SEM6D_HUMAN
θ value	1.38821 (rank : 229)	NC score	0.016830 (rank : 424)
Query Neighborhood Hits	367	Target Neighborhood Hits	169	Shared Neighborhood Hits	19
SwissProt Accessions	Q8NFY4, Q8NFY3, Q8NFY5, Q8NFY6, Q8NFY7, Q9P249	Gene names	SEMA6D, KIAA1479
Domain Architecture	No domain graphic available
Description	Semaphorin-6D precursor.

AHTF1_HUMAN
θ value	1.81305 (rank : 230)	NC score	0.022917 (rank : 404)
Query Neighborhood Hits	367	Target Neighborhood Hits	286	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WYP5, Q7Z4E3, Q8IZA4, Q96EH9, Q9Y4Q6	Gene names	AHCTF1, ELYS, TMBS62
Domain Architecture	No domain graphic available
Description	AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac).

ALS2_HUMAN
θ value	1.81305 (rank : 231)	NC score	0.103744 (rank : 122)
Query Neighborhood Hits	367	Target Neighborhood Hits	121	Shared Neighborhood Hits	26
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

CO039_MOUSE
θ value	1.81305 (rank : 232)	NC score	0.037068 (rank : 350)
Query Neighborhood Hits	367	Target Neighborhood Hits	445	Shared Neighborhood Hits	70
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

ELF1_MOUSE
θ value	1.81305 (rank : 233)	NC score	0.012376 (rank : 449)
Query Neighborhood Hits	367	Target Neighborhood Hits	139	Shared Neighborhood Hits	14
SwissProt Accessions	Q60775	Gene names	Elf1
Domain Architecture
Description	ETS-related transcription factor Elf-1 (E74-like factor 1).

GLYG2_HUMAN
θ value	1.81305 (rank : 234)	NC score	0.026520 (rank : 391)
Query Neighborhood Hits	367	Target Neighborhood Hits	65	Shared Neighborhood Hits	9
SwissProt Accessions	O15488, O15485, O15486, O15487, O15489, O15490	Gene names	GYG2
Domain Architecture
Description	Glycogenin-2 (EC 2.4.1.186) (GN-2) (GN2).

KIF1B_HUMAN
θ value	1.81305 (rank : 235)	NC score	0.015724 (rank : 431)
Query Neighborhood Hits	367	Target Neighborhood Hits	178	Shared Neighborhood Hits	19
SwissProt Accessions	O60333, Q96Q94, Q9BV80, Q9P280	Gene names	KIF1B, KIAA0591, KIAA1448
Domain Architecture
Description	Kinesin-like protein KIF1B (Klp).

KIF1B_MOUSE
θ value	1.81305 (rank : 236)	NC score	0.014457 (rank : 440)
Query Neighborhood Hits	367	Target Neighborhood Hits	167	Shared Neighborhood Hits	17
SwissProt Accessions	Q60575, Q9R0B4, Q9WVE5, Q9Z119	Gene names	Kif1b
Domain Architecture
Description	Kinesin-like protein KIF1B.

MYRIP_HUMAN
θ value	1.81305 (rank : 237)	NC score	0.066262 (rank : 207)
Query Neighborhood Hits	367	Target Neighborhood Hits	269	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

PDZD2_HUMAN
θ value	1.81305 (rank : 238)	NC score	0.024184 (rank : 399)
Query Neighborhood Hits	367	Target Neighborhood Hits	772	Shared Neighborhood Hits	64
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

SEM6D_MOUSE
θ value	1.81305 (rank : 239)	NC score	0.014848 (rank : 439)
Query Neighborhood Hits	367	Target Neighborhood Hits	161	Shared Neighborhood Hits	20
SwissProt Accessions	Q76KF0, Q76KF1, Q76KF2, Q76KF3, Q76KF4, Q80TD0	Gene names	Sema6d, Kiaa1479
Domain Architecture	No domain graphic available
Description	Semaphorin-6D precursor.

SSBP4_HUMAN
θ value	1.81305 (rank : 240)	NC score	0.036855 (rank : 352)
Query Neighborhood Hits	367	Target Neighborhood Hits	753	Shared Neighborhood Hits	85
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

TACC3_HUMAN
θ value	1.81305 (rank : 241)	NC score	0.026803 (rank : 389)
Query Neighborhood Hits	367	Target Neighborhood Hits	779	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

ULK1_MOUSE
θ value	1.81305 (rank : 242)	NC score	0.002939 (rank : 487)
Query Neighborhood Hits	367	Target Neighborhood Hits	1214	Shared Neighborhood Hits	62
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

ZIM10_HUMAN
θ value	1.81305 (rank : 243)	NC score	0.032966 (rank : 369)
Query Neighborhood Hits	367	Target Neighborhood Hits	577	Shared Neighborhood Hits	84
SwissProt Accessions	Q9ULJ6, Q7Z7E6	Gene names	RAI17, KIAA1224, ZIMP10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

BCL9_HUMAN
θ value	2.36792 (rank : 244)	NC score	0.052700 (rank : 290)
Query Neighborhood Hits	367	Target Neighborhood Hits	1008	Shared Neighborhood Hits	117
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

CAC1G_HUMAN
θ value	2.36792 (rank : 245)	NC score	0.012703 (rank : 448)
Query Neighborhood Hits	367	Target Neighborhood Hits	587	Shared Neighborhood Hits	60
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

DLG5_HUMAN
θ value	2.36792 (rank : 246)	NC score	0.027160 (rank : 388)
Query Neighborhood Hits	367	Target Neighborhood Hits	1088	Shared Neighborhood Hits	67
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

E41LB_HUMAN
θ value	2.36792 (rank : 247)	NC score	0.061887 (rank : 231)
Query Neighborhood Hits	367	Target Neighborhood Hits	79	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

EGLN1_MOUSE
θ value	2.36792 (rank : 248)	NC score	0.021520 (rank : 406)
Query Neighborhood Hits	367	Target Neighborhood Hits	88	Shared Neighborhood Hits	16
SwissProt Accessions	Q91YE3, Q8VHJ2, Q922P3	Gene names	Egln1
Domain Architecture
Description	Egl nine homolog 1 (EC 1.14.11.-) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-prolyl hydroxylase 2) (HIF-PH2) (HPH-2) (SM-20).

FOXN1_HUMAN
θ value	2.36792 (rank : 249)	NC score	0.008980 (rank : 462)
Query Neighborhood Hits	367	Target Neighborhood Hits	377	Shared Neighborhood Hits	40
SwissProt Accessions	O15353, O15352	Gene names	FOXN1, WHN
Domain Architecture
Description	Forkhead box protein N1 (Transcription factor winged-helix nude).

GLDN_HUMAN
θ value	2.36792 (rank : 250)	NC score	0.021515 (rank : 407)
Query Neighborhood Hits	367	Target Neighborhood Hits	159	Shared Neighborhood Hits	30
SwissProt Accessions	Q6ZMI3, Q6UXZ7, Q7Z359	Gene names	GLDN, COLM
Domain Architecture	No domain graphic available
Description	Gliomedin.

IWS1_MOUSE
θ value	2.36792 (rank : 251)	NC score	0.027310 (rank : 387)
Query Neighborhood Hits	367	Target Neighborhood Hits	1258	Shared Neighborhood Hits	74
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

NOTC3_MOUSE
θ value	2.36792 (rank : 252)	NC score	0.005726 (rank : 476)
Query Neighborhood Hits	367	Target Neighborhood Hits	975	Shared Neighborhood Hits	47
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

PNMA2_MOUSE
θ value	2.36792 (rank : 253)	NC score	0.013010 (rank : 445)
Query Neighborhood Hits	367	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BHK0	Gene names	Pnma2
Domain Architecture
Description	Paraneoplastic antigen Ma2 homolog.

SRRM1_MOUSE
θ value	2.36792 (rank : 254)	NC score	0.065384 (rank : 210)
Query Neighborhood Hits	367	Target Neighborhood Hits	966	Shared Neighborhood Hits	124
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

TARA_MOUSE
θ value	2.36792 (rank : 255)	NC score	0.053593 (rank : 283)
Query Neighborhood Hits	367	Target Neighborhood Hits	1133	Shared Neighborhood Hits	104
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

ZN385_HUMAN
θ value	2.36792 (rank : 256)	NC score	0.036757 (rank : 353)
Query Neighborhood Hits	367	Target Neighborhood Hits	614	Shared Neighborhood Hits	73
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

3BP2_MOUSE
θ value	3.0926 (rank : 257)	NC score	0.082388 (rank : 148)
Query Neighborhood Hits	367	Target Neighborhood Hits	142	Shared Neighborhood Hits	39
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

CIC_HUMAN
θ value	3.0926 (rank : 258)	NC score	0.048303 (rank : 318)
Query Neighborhood Hits	367	Target Neighborhood Hits	992	Shared Neighborhood Hits	125
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

CK056_MOUSE
θ value	3.0926 (rank : 259)	NC score	0.015682 (rank : 432)
Query Neighborhood Hits	367	Target Neighborhood Hits	42	Shared Neighborhood Hits	13
SwissProt Accessions	Q3U2I3, Q3TWF5, Q6P543, Q80T93, Q811J6, Q8BI34, Q8VE55	Gene names	Kiaa1759
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf56 homolog.

CO3A1_HUMAN
θ value	3.0926 (rank : 260)	NC score	0.047321 (rank : 323)
Query Neighborhood Hits	367	Target Neighborhood Hits	452	Shared Neighborhood Hits	76
SwissProt Accessions	P02461, Q15112, Q16403, Q6LDB3, Q6LDJ2, Q6LDJ3, Q7KZ56	Gene names	COL3A1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

CO4A1_MOUSE
θ value	3.0926 (rank : 261)	NC score	0.036189 (rank : 358)
Query Neighborhood Hits	367	Target Neighborhood Hits	450	Shared Neighborhood Hits	66
SwissProt Accessions	P02463	Gene names	Col4a1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

CYH1_MOUSE
θ value	3.0926 (rank : 262)	NC score	0.050118 (rank : 311)
Query Neighborhood Hits	367	Target Neighborhood Hits	176	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

DP13B_HUMAN
θ value	3.0926 (rank : 263)	NC score	0.040615 (rank : 343)
Query Neighborhood Hits	367	Target Neighborhood Hits	58	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

FLNB_HUMAN
θ value	3.0926 (rank : 264)	NC score	0.025583 (rank : 397)
Query Neighborhood Hits	367	Target Neighborhood Hits	111	Shared Neighborhood Hits	13
SwissProt Accessions	O75369, Q13706, Q8WXS9, Q8WXT0, Q8WXT1, Q8WXT2, Q9NRB5, Q9NT26, Q9UEV9	Gene names	FLNB, FLN1L, FLN3, TABP, TAP
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) (ABP- 280 homolog) (ABP-278) (Filamin 3) (Filamin homolog 1) (Fh1).

FLNB_MOUSE
θ value	3.0926 (rank : 265)	NC score	0.026012 (rank : 394)
Query Neighborhood Hits	367	Target Neighborhood Hits	126	Shared Neighborhood Hits	15
SwissProt Accessions	Q80X90, Q8VHX4, Q8VHX7, Q99KY3	Gene names	Flnb
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (ABP- 280-like protein).

GRIK5_MOUSE
θ value	3.0926 (rank : 266)	NC score	0.003598 (rank : 484)
Query Neighborhood Hits	367	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	Q61626	Gene names	Grik5
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 5 precursor (Glutamate receptor KA-2) (KA2) (Glutamate receptor gamma-2) (GluR gamma-2).

MILK1_MOUSE
θ value	3.0926 (rank : 267)	NC score	0.042263 (rank : 339)
Query Neighborhood Hits	367	Target Neighborhood Hits	788	Shared Neighborhood Hits	102
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

PCID2_HUMAN
θ value	3.0926 (rank : 268)	NC score	0.025376 (rank : 398)
Query Neighborhood Hits	367	Target Neighborhood Hits	6	Shared Neighborhood Hits	4
SwissProt Accessions	Q5JVF3, Q3ZCX1, Q5TC57, Q5TC58, Q9H7K1, Q9HBZ7, Q9NUK6, Q9NVY1, Q9NW44, Q9NWH3	Gene names	PCID2
Domain Architecture	No domain graphic available
Description	PCI domain-containing protein 2 (CSN12-like protein).

PSL1_HUMAN
θ value	3.0926 (rank : 269)	NC score	0.023494 (rank : 403)
Query Neighborhood Hits	367	Target Neighborhood Hits	650	Shared Neighborhood Hits	71
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

ZBT12_HUMAN
θ value	3.0926 (rank : 270)	NC score	-0.005318 (rank : 502)
Query Neighborhood Hits	367	Target Neighborhood Hits	784	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y330, Q5JQ98	Gene names	ZBTB12, C6orf46, G10, NG35
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 12 (Protein G10).

ALMS1_MOUSE
θ value	4.03905 (rank : 271)	NC score	0.017735 (rank : 419)
Query Neighborhood Hits	367	Target Neighborhood Hits	181	Shared Neighborhood Hits	22
SwissProt Accessions	Q8K4E0, Q6A084, Q8C9N9	Gene names	Alms1, Kiaa0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1 homolog.

APCD1_MOUSE
θ value	4.03905 (rank : 272)	NC score	0.009979 (rank : 461)
Query Neighborhood Hits	367	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q3U128, Q3TA99	Gene names	Apcdd1, Drapc1
Domain Architecture	No domain graphic available
Description	Protein APCDD1 precursor (Adenomatosis polyposis coli down-regulated 1 protein homolog).

CD2_MOUSE
θ value	4.03905 (rank : 273)	NC score	0.015166 (rank : 436)
Query Neighborhood Hits	367	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	P08920, Q61394	Gene names	Cd2, Ly-37
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Lymphocyte antigen Ly-37).

CENA1_HUMAN
θ value	4.03905 (rank : 274)	NC score	0.046753 (rank : 326)
Query Neighborhood Hits	367	Target Neighborhood Hits	87	Shared Neighborhood Hits	30
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

CO1A2_HUMAN
θ value	4.03905 (rank : 275)	NC score	0.036128 (rank : 360)
Query Neighborhood Hits	367	Target Neighborhood Hits	329	Shared Neighborhood Hits	62
SwissProt Accessions	P08123, P02464, Q9UEB6, Q9UPH0	Gene names	COL1A2
Domain Architecture
Description	Collagen alpha-2(I) chain precursor.

CO4A1_HUMAN
θ value	4.03905 (rank : 276)	NC score	0.033891 (rank : 366)
Query Neighborhood Hits	367	Target Neighborhood Hits	425	Shared Neighborhood Hits	69
SwissProt Accessions	P02462	Gene names	COL4A1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

CUTL2_HUMAN
θ value	4.03905 (rank : 277)	NC score	0.019775 (rank : 411)
Query Neighborhood Hits	367	Target Neighborhood Hits	906	Shared Neighborhood Hits	70
SwissProt Accessions	O14529	Gene names	CUTL2, KIAA0293
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

FOG1_MOUSE
θ value	4.03905 (rank : 278)	NC score	0.006056 (rank : 472)
Query Neighborhood Hits	367	Target Neighborhood Hits	1237	Shared Neighborhood Hits	106
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

GR65_HUMAN
θ value	4.03905 (rank : 279)	NC score	0.016601 (rank : 427)
Query Neighborhood Hits	367	Target Neighborhood Hits	148	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BQQ3, Q8N272, Q96H42	Gene names	GORASP1, GRASP65
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 1 (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5).

IRX1_HUMAN
θ value	4.03905 (rank : 280)	NC score	0.005889 (rank : 475)
Query Neighborhood Hits	367	Target Neighborhood Hits	285	Shared Neighborhood Hits	19
SwissProt Accessions	P78414, Q7Z2F8, Q8N312	Gene names	IRX1, IRXA1
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-1 (Iroquois homeobox protein 1) (Homeodomain protein IRXA1).

JPH2_HUMAN
θ value	4.03905 (rank : 281)	NC score	0.033277 (rank : 368)
Query Neighborhood Hits	367	Target Neighborhood Hits	639	Shared Neighborhood Hits	87
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

MARK3_HUMAN
θ value	4.03905 (rank : 282)	NC score	0.000073 (rank : 497)
Query Neighborhood Hits	367	Target Neighborhood Hits	893	Shared Neighborhood Hits	17
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

MNT_HUMAN
θ value	4.03905 (rank : 283)	NC score	0.052553 (rank : 291)
Query Neighborhood Hits	367	Target Neighborhood Hits	496	Shared Neighborhood Hits	82
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

TM108_MOUSE
θ value	4.03905 (rank : 284)	NC score	0.025601 (rank : 396)
Query Neighborhood Hits	367	Target Neighborhood Hits	336	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BHE4, Q80WR9	Gene names	Tmem108
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

UBQL3_HUMAN
θ value	4.03905 (rank : 285)	NC score	0.008900 (rank : 463)
Query Neighborhood Hits	367	Target Neighborhood Hits	141	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H347, Q9NRE0	Gene names	UBQLN3
Domain Architecture
Description	Ubiquilin-3.

BRCA1_MOUSE
θ value	5.27518 (rank : 286)	NC score	0.005540 (rank : 477)
Query Neighborhood Hits	367	Target Neighborhood Hits	436	Shared Neighborhood Hits	22
SwissProt Accessions	P48754, Q60957, Q60983	Gene names	Brca1
Domain Architecture
Description	Breast cancer type 1 susceptibility protein homolog.

CAC1B_HUMAN
θ value	5.27518 (rank : 287)	NC score	0.005165 (rank : 479)
Query Neighborhood Hits	367	Target Neighborhood Hits	257	Shared Neighborhood Hits	28
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CD2_HUMAN
θ value	5.27518 (rank : 288)	NC score	0.023578 (rank : 401)
Query Neighborhood Hits	367	Target Neighborhood Hits	504	Shared Neighborhood Hits	55
SwissProt Accessions	P06729, Q96TE5	Gene names	CD2
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Erythrocyte receptor) (Rosette receptor).

CENG2_MOUSE
θ value	5.27518 (rank : 289)	NC score	0.023606 (rank : 400)
Query Neighborhood Hits	367	Target Neighborhood Hits	463	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

CENPF_HUMAN
θ value	5.27518 (rank : 290)	NC score	0.032146 (rank : 373)
Query Neighborhood Hits	367	Target Neighborhood Hits	1932	Shared Neighborhood Hits	69
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

CRK_MOUSE
θ value	5.27518 (rank : 291)	NC score	0.063500 (rank : 219)
Query Neighborhood Hits	367	Target Neighborhood Hits	314	Shared Neighborhood Hits	32
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

DOK1_HUMAN
θ value	5.27518 (rank : 292)	NC score	0.008281 (rank : 464)
Query Neighborhood Hits	367	Target Neighborhood Hits	85	Shared Neighborhood Hits	12
SwissProt Accessions	Q99704, O43204, Q9UHG6	Gene names	DOK1
Domain Architecture
Description	Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62).

ERRFI_MOUSE
θ value	5.27518 (rank : 293)	NC score	0.014343 (rank : 441)
Query Neighborhood Hits	367	Target Neighborhood Hits	72	Shared Neighborhood Hits	16
SwissProt Accessions	Q99JZ7	Gene names	Errfi1, Mig6
Domain Architecture	No domain graphic available
Description	ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein homolog) (Mig-6).

GAK12_HUMAN
θ value	5.27518 (rank : 294)	NC score	0.018256 (rank : 415)
Query Neighborhood Hits	367	Target Neighborhood Hits	374	Shared Neighborhood Hits	44
SwissProt Accessions	P63130, Q9UKI0	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q22 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K102 Gag protein) (HERV-K(III) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GRIK5_HUMAN
θ value	5.27518 (rank : 295)	NC score	0.003088 (rank : 485)
Query Neighborhood Hits	367	Target Neighborhood Hits	44	Shared Neighborhood Hits	4
SwissProt Accessions	Q16478	Gene names	GRIK5, GRIK2
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 5 precursor (Glutamate receptor KA-2) (KA2) (Excitatory amino acid receptor 2) (EAA2).

MYLK_MOUSE
θ value	5.27518 (rank : 296)	NC score	0.004463 (rank : 480)
Query Neighborhood Hits	367	Target Neighborhood Hits	1489	Shared Neighborhood Hits	57
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

NFM_HUMAN
θ value	5.27518 (rank : 297)	NC score	0.019399 (rank : 412)
Query Neighborhood Hits	367	Target Neighborhood Hits	1328	Shared Neighborhood Hits	84
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

NOTC2_HUMAN
θ value	5.27518 (rank : 298)	NC score	0.005185 (rank : 478)
Query Neighborhood Hits	367	Target Neighborhood Hits	1113	Shared Neighborhood Hits	55
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

OST3B_HUMAN
θ value	5.27518 (rank : 299)	NC score	0.002698 (rank : 489)
Query Neighborhood Hits	367	Target Neighborhood Hits	51	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y662	Gene names	HS3ST3B1, 3OST3B1, HS3ST3B
Domain Architecture	No domain graphic available
Description	Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 (EC 2.8.2.30) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1) (Heparan sulfate 3-O-sulfotransferase 3B1) (h3-OST-3B).

PKD2_HUMAN
θ value	5.27518 (rank : 300)	NC score	0.004048 (rank : 483)
Query Neighborhood Hits	367	Target Neighborhood Hits	105	Shared Neighborhood Hits	6
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

PRR12_HUMAN
θ value	5.27518 (rank : 301)	NC score	0.084947 (rank : 142)
Query Neighborhood Hits	367	Target Neighborhood Hits	460	Shared Neighborhood Hits	99
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

RUNX3_HUMAN
θ value	5.27518 (rank : 302)	NC score	0.006698 (rank : 469)
Query Neighborhood Hits	367	Target Neighborhood Hits	96	Shared Neighborhood Hits	13
SwissProt Accessions	Q13761, Q12969, Q13760	Gene names	RUNX3, AML2, CBFA3, PEBP2A3
Domain Architecture
Description	Runt-related transcription factor 3 (Core-binding factor, alpha 3 subunit) (CBF-alpha 3) (Acute myeloid leukemia 2 protein) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEBP2-alpha C) (PEA2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit).

SETBP_MOUSE
θ value	5.27518 (rank : 303)	NC score	0.029895 (rank : 380)
Query Neighborhood Hits	367	Target Neighborhood Hits	352	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Z180, Q66JL8	Gene names	Setbp1, Kiaa0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

ST2B1_HUMAN
θ value	5.27518 (rank : 304)	NC score	0.004187 (rank : 482)
Query Neighborhood Hits	367	Target Neighborhood Hits	57	Shared Neighborhood Hits	12
SwissProt Accessions	O00204, O00205, O75814	Gene names	SULT2B1, HSST2
Domain Architecture	No domain graphic available
Description	Sulfotransferase family cytosolic 2B member 1 (EC 2.8.2.2) (Sulfotransferase 2B1) (Alcohol sulfotransferase) (Hydroxysteroid sulfotransferase 2).

SVIL_HUMAN
θ value	5.27518 (rank : 305)	NC score	0.006676 (rank : 470)
Query Neighborhood Hits	367	Target Neighborhood Hits	232	Shared Neighborhood Hits	16
SwissProt Accessions	O95425, O60611, O60612, Q5VZK5, Q5VZK6, Q9H1R7	Gene names	SVIL
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

TCF8_MOUSE
θ value	5.27518 (rank : 306)	NC score	-0.004200 (rank : 501)
Query Neighborhood Hits	367	Target Neighborhood Hits	1067	Shared Neighborhood Hits	36
SwissProt Accessions	Q64318, Q62519	Gene names	Tcf8, Zfhx1a, Zfx1a, Zfx1ha
Domain Architecture
Description	Transcription factor 8 (Zinc finger homeobox protein 1a) (MEB1) (Delta EF1).

TRI37_HUMAN
θ value	5.27518 (rank : 307)	NC score	0.007740 (rank : 466)
Query Neighborhood Hits	367	Target Neighborhood Hits	307	Shared Neighborhood Hits	13
SwissProt Accessions	O94972, Q7Z3E6, Q8IYF7, Q8WYF7	Gene names	TRIM37, KIAA0898, MUL, POB1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37 (Mulibrey nanism protein).

ATX1_MOUSE
θ value	6.88961 (rank : 308)	NC score	0.012014 (rank : 450)
Query Neighborhood Hits	367	Target Neighborhood Hits	264	Shared Neighborhood Hits	30
SwissProt Accessions	P54254	Gene names	Atxn1, Sca1
Domain Architecture
Description	Ataxin-1 (Spinocerebellar ataxia type 1 protein homolog).

ATX7_MOUSE
θ value	6.88961 (rank : 309)	NC score	0.017130 (rank : 422)
Query Neighborhood Hits	367	Target Neighborhood Hits	328	Shared Neighborhood Hits	49
SwissProt Accessions	Q8R4I1, Q8BL17	Gene names	Atxn7, Sca7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein homolog).

BLNK_MOUSE
θ value	6.88961 (rank : 310)	NC score	0.032037 (rank : 374)
Query Neighborhood Hits	367	Target Neighborhood Hits	296	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

CENG2_HUMAN
θ value	6.88961 (rank : 311)	NC score	0.023534 (rank : 402)
Query Neighborhood Hits	367	Target Neighborhood Hits	471	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

CIC_MOUSE
θ value	6.88961 (rank : 312)	NC score	0.035978 (rank : 361)
Query Neighborhood Hits	367	Target Neighborhood Hits	742	Shared Neighborhood Hits	105
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

CO2A1_HUMAN
θ value	6.88961 (rank : 313)	NC score	0.039828 (rank : 346)
Query Neighborhood Hits	367	Target Neighborhood Hits	486	Shared Neighborhood Hits	67
SwissProt Accessions	P02458, Q12985, Q14009, Q14044, Q14046, Q14056, Q14058, Q16672, Q6LBY1, Q6LBY2, Q6LBY3, Q99227, Q9UE38, Q9UE39, Q9UE40, Q9UE41, Q9UE42, Q9UE43	Gene names	COL2A1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

COBA2_HUMAN
θ value	6.88961 (rank : 314)	NC score	0.036484 (rank : 357)
Query Neighborhood Hits	367	Target Neighborhood Hits	408	Shared Neighborhood Hits	68
SwissProt Accessions	P13942, Q07751, Q13271, Q13272, Q13273, Q99866, Q9UIP9	Gene names	COL11A2
Domain Architecture
Description	Collagen alpha-2(XI) chain precursor.

CONA1_MOUSE
θ value	6.88961 (rank : 315)	NC score	0.032638 (rank : 371)
Query Neighborhood Hits	367	Target Neighborhood Hits	254	Shared Neighborhood Hits	50
SwissProt Accessions	Q8K4G2, Q5SUQ0	Gene names	Col23a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXIII) chain.

GAK11_HUMAN
θ value	6.88961 (rank : 316)	NC score	0.017600 (rank : 420)
Query Neighborhood Hits	367	Target Neighborhood Hits	409	Shared Neighborhood Hits	45
SwissProt Accessions	P63145, Q9UKI1	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_22q11.21 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K101 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK1_HUMAN
θ value	6.88961 (rank : 317)	NC score	0.015602 (rank : 433)
Query Neighborhood Hits	367	Target Neighborhood Hits	268	Shared Neighborhood Hits	33
SwissProt Accessions	P62683	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_12q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK2_HUMAN
θ value	6.88961 (rank : 318)	NC score	0.016717 (rank : 426)
Query Neighborhood Hits	367	Target Neighborhood Hits	406	Shared Neighborhood Hits	43
SwissProt Accessions	Q7LDI9, Q9UKH5, Q9Y6I1, Q9YNA6, Q9YNB0	Gene names	ERVK6
Domain Architecture	No domain graphic available
Description	HERV-K_7p22.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K(C7) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK4_HUMAN
θ value	6.88961 (rank : 319)	NC score	0.017792 (rank : 418)
Query Neighborhood Hits	367	Target Neighborhood Hits	415	Shared Neighborhood Hits	46
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GRB7_HUMAN
θ value	6.88961 (rank : 320)	NC score	0.014207 (rank : 442)
Query Neighborhood Hits	367	Target Neighborhood Hits	156	Shared Neighborhood Hits	14
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

IWS1_HUMAN
θ value	6.88961 (rank : 321)	NC score	0.025607 (rank : 395)
Query Neighborhood Hits	367	Target Neighborhood Hits	1241	Shared Neighborhood Hits	72
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

KIF1C_MOUSE
θ value	6.88961 (rank : 322)	NC score	0.010283 (rank : 459)
Query Neighborhood Hits	367	Target Neighborhood Hits	171	Shared Neighborhood Hits	28
SwissProt Accessions	O35071, Q5SX62	Gene names	Kif1c
Domain Architecture	No domain graphic available
Description	Kinesin-like protein KIF1C.

MDC1_HUMAN
θ value	6.88961 (rank : 323)	NC score	0.046737 (rank : 327)
Query Neighborhood Hits	367	Target Neighborhood Hits	1446	Shared Neighborhood Hits	104
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MTSS1_MOUSE
θ value	6.88961 (rank : 324)	NC score	0.047680 (rank : 320)
Query Neighborhood Hits	367	Target Neighborhood Hits	592	Shared Neighborhood Hits	87
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

MYCB2_HUMAN
θ value	6.88961 (rank : 325)	NC score	0.011376 (rank : 454)
Query Neighborhood Hits	367	Target Neighborhood Hits	390	Shared Neighborhood Hits	40
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

OBSL1_HUMAN
θ value	6.88961 (rank : 326)	NC score	0.010974 (rank : 456)
Query Neighborhood Hits	367	Target Neighborhood Hits	354	Shared Neighborhood Hits	7
SwissProt Accessions	O75147, Q96IW3	Gene names	OBSL1, KIAA0657
Domain Architecture	No domain graphic available
Description	Obscurin-like protein 1 precursor.

ROBO4_MOUSE
θ value	6.88961 (rank : 327)	NC score	0.007945 (rank : 465)
Query Neighborhood Hits	367	Target Neighborhood Hits	358	Shared Neighborhood Hits	17
SwissProt Accessions	Q8C310, Q9DBW1	Gene names	Robo4
Domain Architecture
Description	Roundabout homolog 4 precursor.

SPRE2_MOUSE
θ value	6.88961 (rank : 328)	NC score	0.010816 (rank : 458)
Query Neighborhood Hits	367	Target Neighborhood Hits	41	Shared Neighborhood Hits	5
SwissProt Accessions	Q924S7	Gene names	Spred2
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 2 (Spred-2).

SUHW3_HUMAN
θ value	6.88961 (rank : 329)	NC score	-0.003239 (rank : 500)
Query Neighborhood Hits	367	Target Neighborhood Hits	695	Shared Neighborhood Hits	16
SwissProt Accessions	Q8ND82, Q9NXR3	Gene names	SUHW3
Domain Architecture	No domain graphic available
Description	Suppressor of hairy wing homolog 3.

TIF1G_HUMAN
θ value	6.88961 (rank : 330)	NC score	0.011857 (rank : 451)
Query Neighborhood Hits	367	Target Neighborhood Hits	410	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UPN9, O95855, Q9C017, Q9UJ79	Gene names	TRIM33, KIAA1113, RFG7, TIF1G
Domain Architecture
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33) (RET-fused gene 7 protein) (Rfg7 protein).

TIF1G_MOUSE
θ value	6.88961 (rank : 331)	NC score	0.012880 (rank : 447)
Query Neighborhood Hits	367	Target Neighborhood Hits	498	Shared Neighborhood Hits	52
SwissProt Accessions	Q99PP7, Q6SI71, Q6ZPX5	Gene names	Trim33, Kiaa1113
Domain Architecture	No domain graphic available
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33).

TS13_MOUSE
θ value	6.88961 (rank : 332)	NC score	0.017371 (rank : 421)
Query Neighborhood Hits	367	Target Neighborhood Hits	191	Shared Neighborhood Hits	26
SwissProt Accessions	Q01755	Gene names	Tcp11
Domain Architecture
Description	Testis-specific protein PBS13.

WNT5A_HUMAN
θ value	6.88961 (rank : 333)	NC score	0.002496 (rank : 492)
Query Neighborhood Hits	367	Target Neighborhood Hits	48	Shared Neighborhood Hits	5
SwissProt Accessions	P41221	Gene names	WNT5A
Domain Architecture
Description	Protein Wnt-5a precursor.

WNT5A_MOUSE
θ value	6.88961 (rank : 334)	NC score	0.002507 (rank : 491)
Query Neighborhood Hits	367	Target Neighborhood Hits	48	Shared Neighborhood Hits	5
SwissProt Accessions	P22725	Gene names	Wnt5a, Wnt-5a
Domain Architecture
Description	Protein Wnt-5a precursor.

ZN564_HUMAN
θ value	6.88961 (rank : 335)	NC score	-0.007912 (rank : 505)
Query Neighborhood Hits	367	Target Neighborhood Hits	746	Shared Neighborhood Hits	15
SwissProt Accessions	Q8TBZ8	Gene names	ZNF564
Domain Architecture	No domain graphic available
Description	Zinc finger protein 564.

AFF2_MOUSE
θ value	8.99809 (rank : 336)	NC score	0.013353 (rank : 444)
Query Neighborhood Hits	367	Target Neighborhood Hits	225	Shared Neighborhood Hits	29
SwissProt Accessions	O55112	Gene names	Aff2, Fmr2, Ox19
Domain Architecture
Description	AF4/FMR2 family member 2 (Fragile X mental retardation protein 2 homolog) (Protein FMR-2) (FMR2P) (Protein Ox19).

CBP_HUMAN
θ value	8.99809 (rank : 337)	NC score	0.035952 (rank : 362)
Query Neighborhood Hits	367	Target Neighborhood Hits	941	Shared Neighborhood Hits	107
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CENPE_HUMAN
θ value	8.99809 (rank : 338)	NC score	0.027330 (rank : 386)
Query Neighborhood Hits	367	Target Neighborhood Hits	2060	Shared Neighborhood Hits	78
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

CN044_MOUSE
θ value	8.99809 (rank : 339)	NC score	0.011162 (rank : 455)
Query Neighborhood Hits	367	Target Neighborhood Hits	57	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CB59, Q8BQX8, Q8BSL9, Q8CBZ3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf44 homolog.

CO4A3_HUMAN
θ value	8.99809 (rank : 340)	NC score	0.037182 (rank : 349)
Query Neighborhood Hits	367	Target Neighborhood Hits	421	Shared Neighborhood Hits	65
SwissProt Accessions	Q01955, Q9BQT2	Gene names	COL4A3
Domain Architecture
Description	Collagen alpha-3(IV) chain precursor (Goodpasture antigen).

COIA1_HUMAN
θ value	8.99809 (rank : 341)	NC score	0.032704 (rank : 370)
Query Neighborhood Hits	367	Target Neighborhood Hits	447	Shared Neighborhood Hits	76
SwissProt Accessions	P39060, Q9UK38, Q9Y6Q7, Q9Y6Q8	Gene names	COL18A1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

CSKI1_MOUSE
θ value	8.99809 (rank : 342)	NC score	0.029623 (rank : 381)
Query Neighborhood Hits	367	Target Neighborhood Hits	1031	Shared Neighborhood Hits	123
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CTRO_HUMAN
θ value	8.99809 (rank : 343)	NC score	0.015162 (rank : 437)
Query Neighborhood Hits	367	Target Neighborhood Hits	2092	Shared Neighborhood Hits	78
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

CYH1_HUMAN
θ value	8.99809 (rank : 344)	NC score	0.051834 (rank : 298)
Query Neighborhood Hits	367	Target Neighborhood Hits	184	Shared Neighborhood Hits	40
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

DMRTD_MOUSE
θ value	8.99809 (rank : 345)	NC score	0.007680 (rank : 467)
Query Neighborhood Hits	367	Target Neighborhood Hits	72	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CGW9	Gene names	Dmrtc2, Dmrt7
Domain Architecture	No domain graphic available
Description	Doublesex- and mab-3-related transcription factor C2 (Doublesex- and mab-3-related transcription factor 7).

DP13B_MOUSE
θ value	8.99809 (rank : 346)	NC score	0.034534 (rank : 365)
Query Neighborhood Hits	367	Target Neighborhood Hits	58	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

FHL5_HUMAN
θ value	8.99809 (rank : 347)	NC score	-0.000393 (rank : 498)
Query Neighborhood Hits	367	Target Neighborhood Hits	523	Shared Neighborhood Hits	7
SwissProt Accessions	Q5TD97, Q5TD98, Q8WW21, Q9NQU2	Gene names	FHL5, ACT
Domain Architecture	No domain graphic available
Description	Four and a half LIM domains protein 5 (FHL-5) (Activator of cAMP- responsive element modulator in testis) (Activator of CREM in testis).

GAK5_HUMAN
θ value	8.99809 (rank : 348)	NC score	0.018872 (rank : 413)
Query Neighborhood Hits	367	Target Neighborhood Hits	429	Shared Neighborhood Hits	48
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

HEM1_HUMAN
θ value	8.99809 (rank : 349)	NC score	0.002757 (rank : 488)
Query Neighborhood Hits	367	Target Neighborhood Hits	45	Shared Neighborhood Hits	3
SwissProt Accessions	P13196	Gene names	ALAS1, ALASH
Domain Architecture
Description	5-aminolevulinate synthase, nonspecific, mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta-aminolevulinate synthase) (Delta-ALA synthetase) (ALAS-H).

ITA1_HUMAN
θ value	8.99809 (rank : 350)	NC score	0.001174 (rank : 496)
Query Neighborhood Hits	367	Target Neighborhood Hits	75	Shared Neighborhood Hits	7
SwissProt Accessions	P56199	Gene names	ITGA1
Domain Architecture	No domain graphic available
Description	Integrin alpha-1 (Laminin and collagen receptor) (VLA-1) (CD49a antigen).

KPCG_HUMAN
θ value	8.99809 (rank : 351)	NC score	0.011755 (rank : 453)
Query Neighborhood Hits	367	Target Neighborhood Hits	1126	Shared Neighborhood Hits	38
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCG_MOUSE
θ value	8.99809 (rank : 352)	NC score	0.010838 (rank : 457)
Query Neighborhood Hits	367	Target Neighborhood Hits	1123	Shared Neighborhood Hits	37
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

LEO1_HUMAN
θ value	8.99809 (rank : 353)	NC score	0.005890 (rank : 474)
Query Neighborhood Hits	367	Target Neighborhood Hits	958	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

MK15_HUMAN
θ value	8.99809 (rank : 354)	NC score	-0.001004 (rank : 499)
Query Neighborhood Hits	367	Target Neighborhood Hits	1038	Shared Neighborhood Hits	46
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

MTSS1_HUMAN
θ value	8.99809 (rank : 355)	NC score	0.027678 (rank : 385)
Query Neighborhood Hits	367	Target Neighborhood Hits	504	Shared Neighborhood Hits	66
SwissProt Accessions	O43312, Q8TCA2, Q96RX2	Gene names	MTSS1, KIAA0429, MIM
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein) (Metastasis suppressor YGL-1).

MYO15_MOUSE
θ value	8.99809 (rank : 356)	NC score	0.012936 (rank : 446)
Query Neighborhood Hits	367	Target Neighborhood Hits	467	Shared Neighborhood Hits	73
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

PDLI7_HUMAN
θ value	8.99809 (rank : 357)	NC score	0.010216 (rank : 460)
Query Neighborhood Hits	367	Target Neighborhood Hits	547	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PRB4S_HUMAN
θ value	8.99809 (rank : 358)	NC score	0.069901 (rank : 187)
Query Neighborhood Hits	367	Target Neighborhood Hits	330	Shared Neighborhood Hits	84
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

SBK1_HUMAN
θ value	8.99809 (rank : 359)	NC score	0.002263 (rank : 493)
Query Neighborhood Hits	367	Target Neighborhood Hits	828	Shared Neighborhood Hits	19
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

SMAD1_HUMAN
θ value	8.99809 (rank : 360)	NC score	0.002974 (rank : 486)
Query Neighborhood Hits	367	Target Neighborhood Hits	59	Shared Neighborhood Hits	12
SwissProt Accessions	Q15797, Q16636	Gene names	SMAD1, BSP1, MADH1, MADR1
Domain Architecture
Description	Mothers against decapentaplegic homolog 1 (SMAD 1) (Mothers against DPP homolog 1) (Mad-related protein 1) (Transforming growth factor- beta signaling protein 1) (BSP-1) (hSMAD1) (JV4-1).

SRRM2_MOUSE
θ value	8.99809 (rank : 361)	NC score	0.047151 (rank : 324)
Query Neighborhood Hits	367	Target Neighborhood Hits	1470	Shared Neighborhood Hits	121
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

STON1_HUMAN
θ value	8.99809 (rank : 362)	NC score	0.004259 (rank : 481)
Query Neighborhood Hits	367	Target Neighborhood Hits	49	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y6Q2, Q96JE3, Q9BYX3	Gene names	STON1, SALF, SBLF, STN1
Domain Architecture
Description	Stonin-1 (Stoned B-like factor).

SYNJ1_MOUSE
θ value	8.99809 (rank : 363)	NC score	0.036156 (rank : 359)
Query Neighborhood Hits	367	Target Neighborhood Hits	516	Shared Neighborhood Hits	96
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

TERF2_HUMAN
θ value	8.99809 (rank : 364)	NC score	0.005969 (rank : 473)
Query Neighborhood Hits	367	Target Neighborhood Hits	102	Shared Neighborhood Hits	8
SwissProt Accessions	Q15554	Gene names	TERF2, TRF2
Domain Architecture
Description	Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein).

TPO_MOUSE
θ value	8.99809 (rank : 365)	NC score	0.015297 (rank : 435)
Query Neighborhood Hits	367	Target Neighborhood Hits	258	Shared Neighborhood Hits	25
SwissProt Accessions	P40226	Gene names	Thpo
Domain Architecture
Description	Thrombopoietin precursor (Megakaryocyte colony-stimulating factor) (Myeloproliferative leukemia virus oncogene ligand) (C-mpl ligand) (ML) (Megakaryocyte growth and development factor) (MGDF).

UBP21_HUMAN
θ value	8.99809 (rank : 366)	NC score	0.001414 (rank : 495)
Query Neighborhood Hits	367	Target Neighborhood Hits	95	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UK80, Q9BTV1, Q9NYN4	Gene names	USP21, USP23
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.1.2.15) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21) (Deubiquitinating enzyme 21) (NEDD8-specific protease).

ZN142_HUMAN
θ value	8.99809 (rank : 367)	NC score	-0.005554 (rank : 503)
Query Neighborhood Hits	367	Target Neighborhood Hits	1007	Shared Neighborhood Hits	56
SwissProt Accessions	P52746, Q92510	Gene names	ZNF142, KIAA0236
Domain Architecture	No domain graphic available
Description	Zinc finger protein 142 (HA4654).

41_HUMAN
θ value	θ > 10 (rank : 368)	NC score	0.059928 (rank : 241)
Query Neighborhood Hits	367	Target Neighborhood Hits	157	Shared Neighborhood Hits	16
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

41_MOUSE
θ value	θ > 10 (rank : 369)	NC score	0.059050 (rank : 248)
Query Neighborhood Hits	367	Target Neighborhood Hits	184	Shared Neighborhood Hits	19
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

ABI1_HUMAN
θ value	θ > 10 (rank : 370)	NC score	0.062963 (rank : 220)
Query Neighborhood Hits	367	Target Neighborhood Hits	257	Shared Neighborhood Hits	45
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 371)	NC score	0.066450 (rank : 204)
Query Neighborhood Hits	367	Target Neighborhood Hits	246	Shared Neighborhood Hits	43
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 372)	NC score	0.074727 (rank : 172)
Query Neighborhood Hits	367	Target Neighborhood Hits	350	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 373)	NC score	0.068475 (rank : 192)
Query Neighborhood Hits	367	Target Neighborhood Hits	266	Shared Neighborhood Hits	41
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 374)	NC score	0.064490 (rank : 214)
Query Neighborhood Hits	367	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 375)	NC score	0.062579 (rank : 223)
Query Neighborhood Hits	367	Target Neighborhood Hits	227	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AHI1_HUMAN
θ value	θ > 10 (rank : 376)	NC score	0.062598 (rank : 222)
Query Neighborhood Hits	367	Target Neighborhood Hits	537	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 377)	NC score	0.056300 (rank : 270)
Query Neighborhood Hits	367	Target Neighborhood Hits	496	Shared Neighborhood Hits	38
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ARHG6_HUMAN
θ value	θ > 10 (rank : 378)	NC score	0.353132 (rank : 81)
Query Neighborhood Hits	367	Target Neighborhood Hits	376	Shared Neighborhood Hits	74
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	θ > 10 (rank : 379)	NC score	0.322606 (rank : 87)
Query Neighborhood Hits	367	Target Neighborhood Hits	394	Shared Neighborhood Hits	75
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG8_MOUSE
θ value	θ > 10 (rank : 380)	NC score	0.415321 (rank : 68)
Query Neighborhood Hits	367	Target Neighborhood Hits	79	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ASPP1_HUMAN
θ value	θ > 10 (rank : 381)	NC score	0.058012 (rank : 254)
Query Neighborhood Hits	367	Target Neighborhood Hits	956	Shared Neighborhood Hits	89
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BAT2_MOUSE
θ value	θ > 10 (rank : 382)	NC score	0.051015 (rank : 306)
Query Neighborhood Hits	367	Target Neighborhood Hits	947	Shared Neighborhood Hits	128
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

BI2L1_HUMAN
θ value	θ > 10 (rank : 383)	NC score	0.067142 (rank : 195)
Query Neighborhood Hits	367	Target Neighborhood Hits	156	Shared Neighborhood Hits	32
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 384)	NC score	0.055349 (rank : 277)
Query Neighborhood Hits	367	Target Neighborhood Hits	197	Shared Neighborhood Hits	37
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CASL_HUMAN
θ value	θ > 10 (rank : 385)	NC score	0.057948 (rank : 255)
Query Neighborhood Hits	367	Target Neighborhood Hits	259	Shared Neighborhood Hits	39
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	θ > 10 (rank : 386)	NC score	0.054105 (rank : 280)
Query Neighborhood Hits	367	Target Neighborhood Hits	225	Shared Neighborhood Hits	35
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CD2AP_HUMAN
θ value	θ > 10 (rank : 387)	NC score	0.101916 (rank : 124)
Query Neighborhood Hits	367	Target Neighborhood Hits	315	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 388)	NC score	0.101322 (rank : 125)
Query Neighborhood Hits	367	Target Neighborhood Hits	336	Shared Neighborhood Hits	55
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CEND1_MOUSE
θ value	θ > 10 (rank : 389)	NC score	0.052821 (rank : 288)
Query Neighborhood Hits	367	Target Neighborhood Hits	260	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CJ078_MOUSE
θ value	θ > 10 (rank : 390)	NC score	0.060839 (rank : 236)
Query Neighborhood Hits	367	Target Neighborhood Hits	559	Shared Neighborhood Hits	89
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

CNKR1_HUMAN
θ value	θ > 10 (rank : 391)	NC score	0.087899 (rank : 139)
Query Neighborhood Hits	367	Target Neighborhood Hits	154	Shared Neighborhood Hits	42
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CNKR2_HUMAN
θ value	θ > 10 (rank : 392)	NC score	0.073306 (rank : 176)
Query Neighborhood Hits	367	Target Neighborhood Hits	197	Shared Neighborhood Hits	34
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	θ > 10 (rank : 393)	NC score	0.073614 (rank : 175)
Query Neighborhood Hits	367	Target Neighborhood Hits	197	Shared Neighborhood Hits	34
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CRKL_HUMAN
θ value	θ > 10 (rank : 394)	NC score	0.064301 (rank : 216)
Query Neighborhood Hits	367	Target Neighborhood Hits	313	Shared Neighborhood Hits	29
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 395)	NC score	0.062232 (rank : 225)
Query Neighborhood Hits	367	Target Neighborhood Hits	307	Shared Neighborhood Hits	27
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 396)	NC score	0.059471 (rank : 243)
Query Neighborhood Hits	367	Target Neighborhood Hits	308	Shared Neighborhood Hits	30
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CT032_HUMAN
θ value	θ > 10 (rank : 397)	NC score	0.058250 (rank : 252)
Query Neighborhood Hits	367	Target Neighborhood Hits	235	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

CYH3_MOUSE
θ value	θ > 10 (rank : 398)	NC score	0.065310 (rank : 211)
Query Neighborhood Hits	367	Target Neighborhood Hits	148	Shared Neighborhood Hits	39
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

CYH4_HUMAN
θ value	θ > 10 (rank : 399)	NC score	0.050007 (rank : 314)
Query Neighborhood Hits	367	Target Neighborhood Hits	135	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

CYH4_MOUSE
θ value	θ > 10 (rank : 400)	NC score	0.055714 (rank : 273)
Query Neighborhood Hits	367	Target Neighborhood Hits	134	Shared Neighborhood Hits	37
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

DBNL_HUMAN
θ value	θ > 10 (rank : 401)	NC score	0.053219 (rank : 286)
Query Neighborhood Hits	367	Target Neighborhood Hits	244	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 402)	NC score	0.052232 (rank : 295)
Query Neighborhood Hits	367	Target Neighborhood Hits	306	Shared Neighborhood Hits	34
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DDEF1_MOUSE
θ value	θ > 10 (rank : 403)	NC score	0.059261 (rank : 247)
Query Neighborhood Hits	367	Target Neighborhood Hits	592	Shared Neighborhood Hits	77
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_HUMAN
θ value	θ > 10 (rank : 404)	NC score	0.065851 (rank : 208)
Query Neighborhood Hits	367	Target Neighborhood Hits	599	Shared Neighborhood Hits	92
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	θ > 10 (rank : 405)	NC score	0.066623 (rank : 202)
Query Neighborhood Hits	367	Target Neighborhood Hits	625	Shared Neighborhood Hits	96
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

E41L1_HUMAN
θ value	θ > 10 (rank : 406)	NC score	0.057449 (rank : 260)
Query Neighborhood Hits	367	Target Neighborhood Hits	180	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L1_MOUSE
θ value	θ > 10 (rank : 407)	NC score	0.056477 (rank : 267)
Query Neighborhood Hits	367	Target Neighborhood Hits	106	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L2_HUMAN
θ value	θ > 10 (rank : 408)	NC score	0.055938 (rank : 272)
Query Neighborhood Hits	367	Target Neighborhood Hits	287	Shared Neighborhood Hits	15
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41L2_MOUSE
θ value	θ > 10 (rank : 409)	NC score	0.057942 (rank : 256)
Query Neighborhood Hits	367	Target Neighborhood Hits	459	Shared Neighborhood Hits	26
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41L3_HUMAN
θ value	θ > 10 (rank : 410)	NC score	0.059049 (rank : 249)
Query Neighborhood Hits	367	Target Neighborhood Hits	113	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

E41L3_MOUSE
θ value	θ > 10 (rank : 411)	NC score	0.057216 (rank : 262)
Query Neighborhood Hits	367	Target Neighborhood Hits	250	Shared Neighborhood Hits	12
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

E41L5_HUMAN
θ value	θ > 10 (rank : 412)	NC score	0.059373 (rank : 245)
Query Neighborhood Hits	367	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

E41LA_HUMAN
θ value	θ > 10 (rank : 413)	NC score	0.054663 (rank : 278)
Query Neighborhood Hits	367	Target Neighborhood Hits	87	Shared Neighborhood Hits	10
SwissProt Accessions	Q9HCS5	Gene names	EPB41L4A, EPB41L4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41LA_MOUSE
θ value	θ > 10 (rank : 414)	NC score	0.053461 (rank : 284)
Query Neighborhood Hits	367	Target Neighborhood Hits	85	Shared Neighborhood Hits	11
SwissProt Accessions	P52963	Gene names	Epb41l4a, Epb4.1l4, Epb4.1l4a, Epb41l4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41LB_MOUSE
θ value	θ > 10 (rank : 415)	NC score	0.059607 (rank : 242)
Query Neighborhood Hits	367	Target Neighborhood Hits	59	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

EFS_HUMAN
θ value	θ > 10 (rank : 416)	NC score	0.066963 (rank : 199)
Query Neighborhood Hits	367	Target Neighborhood Hits	348	Shared Neighborhood Hits	64
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

ENAH_MOUSE
θ value	θ > 10 (rank : 417)	NC score	0.056787 (rank : 264)
Query Neighborhood Hits	367	Target Neighborhood Hits	919	Shared Neighborhood Hits	120
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

FNBP2_HUMAN
θ value	θ > 10 (rank : 418)	NC score	0.050109 (rank : 313)
Query Neighborhood Hits	367	Target Neighborhood Hits	432	Shared Neighborhood Hits	46
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

FRMD5_HUMAN
θ value	θ > 10 (rank : 419)	NC score	0.057139 (rank : 263)
Query Neighborhood Hits	367	Target Neighborhood Hits	55	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

FRMD5_MOUSE
θ value	θ > 10 (rank : 420)	NC score	0.057523 (rank : 259)
Query Neighborhood Hits	367	Target Neighborhood Hits	55	Shared Neighborhood Hits	5
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

GRAP2_HUMAN
θ value	θ > 10 (rank : 421)	NC score	0.067329 (rank : 194)
Query Neighborhood Hits	367	Target Neighborhood Hits	304	Shared Neighborhood Hits	31
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 422)	NC score	0.066488 (rank : 203)
Query Neighborhood Hits	367	Target Neighborhood Hits	297	Shared Neighborhood Hits	28
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 423)	NC score	0.083403 (rank : 146)
Query Neighborhood Hits	367	Target Neighborhood Hits	307	Shared Neighborhood Hits	35
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 424)	NC score	0.081029 (rank : 152)
Query Neighborhood Hits	367	Target Neighborhood Hits	309	Shared Neighborhood Hits	34
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 425)	NC score	0.072504 (rank : 180)
Query Neighborhood Hits	367	Target Neighborhood Hits	310	Shared Neighborhood Hits	32
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 426)	NC score	0.072503 (rank : 181)
Query Neighborhood Hits	367	Target Neighborhood Hits	312	Shared Neighborhood Hits	32
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRP3_HUMAN
θ value	θ > 10 (rank : 427)	NC score	0.059946 (rank : 240)
Query Neighborhood Hits	367	Target Neighborhood Hits	131	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

GSCR1_HUMAN
θ value	θ > 10 (rank : 428)	NC score	0.055381 (rank : 276)
Query Neighborhood Hits	367	Target Neighborhood Hits	674	Shared Neighborhood Hits	117
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

HCLS1_HUMAN
θ value	θ > 10 (rank : 429)	NC score	0.073066 (rank : 177)
Query Neighborhood Hits	367	Target Neighborhood Hits	358	Shared Neighborhood Hits	54
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 430)	NC score	0.073893 (rank : 174)
Query Neighborhood Hits	367	Target Neighborhood Hits	329	Shared Neighborhood Hits	52
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

IASPP_HUMAN
θ value	θ > 10 (rank : 431)	NC score	0.067401 (rank : 193)
Query Neighborhood Hits	367	Target Neighborhood Hits	688	Shared Neighborhood Hits	109
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

LASP1_HUMAN
θ value	θ > 10 (rank : 432)	NC score	0.051292 (rank : 304)
Query Neighborhood Hits	367	Target Neighborhood Hits	293	Shared Neighborhood Hits	32
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

MBD6_HUMAN
θ value	θ > 10 (rank : 433)	NC score	0.053647 (rank : 282)
Query Neighborhood Hits	367	Target Neighborhood Hits	349	Shared Neighborhood Hits	68
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

MLL2_HUMAN
θ value	θ > 10 (rank : 434)	NC score	0.067132 (rank : 196)
Query Neighborhood Hits	367	Target Neighborhood Hits	1788	Shared Neighborhood Hits	178
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

MUC7_HUMAN
θ value	θ > 10 (rank : 435)	NC score	0.063714 (rank : 217)
Query Neighborhood Hits	367	Target Neighborhood Hits	538	Shared Neighborhood Hits	86
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

NCF1_HUMAN
θ value	θ > 10 (rank : 436)	NC score	0.107137 (rank : 121)
Query Neighborhood Hits	367	Target Neighborhood Hits	198	Shared Neighborhood Hits	33
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 437)	NC score	0.099600 (rank : 127)
Query Neighborhood Hits	367	Target Neighborhood Hits	198	Shared Neighborhood Hits	31
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 438)	NC score	0.089654 (rank : 137)
Query Neighborhood Hits	367	Target Neighborhood Hits	229	Shared Neighborhood Hits	30
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 439)	NC score	0.076769 (rank : 170)
Query Neighborhood Hits	367	Target Neighborhood Hits	161	Shared Neighborhood Hits	21
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 440)	NC score	0.077760 (rank : 168)
Query Neighborhood Hits	367	Target Neighborhood Hits	177	Shared Neighborhood Hits	24
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 441)	NC score	0.084176 (rank : 143)
Query Neighborhood Hits	367	Target Neighborhood Hits	312	Shared Neighborhood Hits	36
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 442)	NC score	0.081831 (rank : 151)
Query Neighborhood Hits	367	Target Neighborhood Hits	310	Shared Neighborhood Hits	38
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NEBL_HUMAN
θ value	θ > 10 (rank : 443)	NC score	0.055447 (rank : 275)
Query Neighborhood Hits	367	Target Neighborhood Hits	457	Shared Neighborhood Hits	37
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 444)	NC score	0.057290 (rank : 261)
Query Neighborhood Hits	367	Target Neighborhood Hits	267	Shared Neighborhood Hits	29
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OSTF1_HUMAN
θ value	θ > 10 (rank : 445)	NC score	0.056351 (rank : 269)
Query Neighborhood Hits	367	Target Neighborhood Hits	466	Shared Neighborhood Hits	37
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 446)	NC score	0.056197 (rank : 271)
Query Neighborhood Hits	367	Target Neighborhood Hits	467	Shared Neighborhood Hits	37
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PCQAP_HUMAN
θ value	θ > 10 (rank : 447)	NC score	0.060931 (rank : 235)
Query Neighborhood Hits	367	Target Neighborhood Hits	549	Shared Neighborhood Hits	78
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

PCQAP_MOUSE
θ value	θ > 10 (rank : 448)	NC score	0.056525 (rank : 266)
Query Neighborhood Hits	367	Target Neighborhood Hits	506	Shared Neighborhood Hits	75
SwissProt Accessions	Q924H2	Gene names	Pcqap
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (mPcqap).

PEX13_HUMAN
θ value	θ > 10 (rank : 449)	NC score	0.051451 (rank : 302)
Query Neighborhood Hits	367	Target Neighborhood Hits	128	Shared Neighborhood Hits	28
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 450)	NC score	0.052247 (rank : 294)
Query Neighborhood Hits	367	Target Neighborhood Hits	126	Shared Neighborhood Hits	22
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PKHA1_HUMAN
θ value	θ > 10 (rank : 451)	NC score	0.050116 (rank : 312)
Query Neighborhood Hits	367	Target Neighborhood Hits	127	Shared Neighborhood Hits	36
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_HUMAN
θ value	θ > 10 (rank : 452)	NC score	0.072440 (rank : 182)
Query Neighborhood Hits	367	Target Neighborhood Hits	119	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHA2_MOUSE
θ value	θ > 10 (rank : 453)	NC score	0.079756 (rank : 158)
Query Neighborhood Hits	367	Target Neighborhood Hits	116	Shared Neighborhood Hits	38
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PLCG1_HUMAN
θ value	θ > 10 (rank : 454)	NC score	0.059408 (rank : 244)
Query Neighborhood Hits	367	Target Neighborhood Hits	293	Shared Neighborhood Hits	30
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 455)	NC score	0.060735 (rank : 237)
Query Neighborhood Hits	367	Target Neighborhood Hits	314	Shared Neighborhood Hits	31
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLEK_HUMAN
θ value	θ > 10 (rank : 456)	NC score	0.057924 (rank : 257)
Query Neighborhood Hits	367	Target Neighborhood Hits	110	Shared Neighborhood Hits	31
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PLEK_MOUSE
θ value	θ > 10 (rank : 457)	NC score	0.051667 (rank : 301)
Query Neighborhood Hits	367	Target Neighborhood Hits	109	Shared Neighborhood Hits	24
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

PPIP1_HUMAN
θ value	θ > 10 (rank : 458)	NC score	0.069590 (rank : 188)
Query Neighborhood Hits	367	Target Neighborhood Hits	389	Shared Neighborhood Hits	38
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 459)	NC score	0.066988 (rank : 198)
Query Neighborhood Hits	367	Target Neighborhood Hits	377	Shared Neighborhood Hits	40
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PRB3_HUMAN
θ value	θ > 10 (rank : 460)	NC score	0.061909 (rank : 229)
Query Neighborhood Hits	367	Target Neighborhood Hits	318	Shared Neighborhood Hits	83
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

PRG4_HUMAN
θ value	θ > 10 (rank : 461)	NC score	0.061384 (rank : 233)
Query Neighborhood Hits	367	Target Neighborhood Hits	764	Shared Neighborhood Hits	107
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PRP1_HUMAN
θ value	θ > 10 (rank : 462)	NC score	0.070641 (rank : 185)
Query Neighborhood Hits	367	Target Neighborhood Hits	385	Shared Neighborhood Hits	99
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

PRP2_MOUSE
θ value	θ > 10 (rank : 463)	NC score	0.082441 (rank : 147)
Query Neighborhood Hits	367	Target Neighborhood Hits	347	Shared Neighborhood Hits	87
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

RFFL_MOUSE
θ value	θ > 10 (rank : 464)	NC score	0.054547 (rank : 279)
Query Neighborhood Hits	367	Target Neighborhood Hits	145	Shared Neighborhood Hits	38
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RHG04_HUMAN
θ value	θ > 10 (rank : 465)	NC score	0.057902 (rank : 258)
Query Neighborhood Hits	367	Target Neighborhood Hits	307	Shared Neighborhood Hits	33
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RHG26_HUMAN
θ value	θ > 10 (rank : 466)	NC score	0.052501 (rank : 292)
Query Neighborhood Hits	367	Target Neighborhood Hits	281	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RNF34_MOUSE
θ value	θ > 10 (rank : 467)	NC score	0.051159 (rank : 305)
Query Neighborhood Hits	367	Target Neighborhood Hits	160	Shared Neighborhood Hits	35
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

RPGF1_HUMAN
θ value	θ > 10 (rank : 468)	NC score	0.050138 (rank : 310)
Query Neighborhood Hits	367	Target Neighborhood Hits	262	Shared Neighborhood Hits	27
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

RUFY3_HUMAN
θ value	θ > 10 (rank : 469)	NC score	0.064779 (rank : 213)
Query Neighborhood Hits	367	Target Neighborhood Hits	594	Shared Neighborhood Hits	25
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RUFY3_MOUSE
θ value	θ > 10 (rank : 470)	NC score	0.065209 (rank : 212)
Query Neighborhood Hits	367	Target Neighborhood Hits	579	Shared Neighborhood Hits	26
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

SH3G1_HUMAN
θ value	θ > 10 (rank : 471)	NC score	0.062392 (rank : 224)
Query Neighborhood Hits	367	Target Neighborhood Hits	307	Shared Neighborhood Hits	33
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 472)	NC score	0.059284 (rank : 246)
Query Neighborhood Hits	367	Target Neighborhood Hits	291	Shared Neighborhood Hits	29
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 473)	NC score	0.062042 (rank : 228)
Query Neighborhood Hits	367	Target Neighborhood Hits	324	Shared Neighborhood Hits	36
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 474)	NC score	0.060369 (rank : 239)
Query Neighborhood Hits	367	Target Neighborhood Hits	319	Shared Neighborhood Hits	36
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 475)	NC score	0.061453 (rank : 232)
Query Neighborhood Hits	367	Target Neighborhood Hits	222	Shared Neighborhood Hits	27
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 476)	NC score	0.062070 (rank : 227)
Query Neighborhood Hits	367	Target Neighborhood Hits	236	Shared Neighborhood Hits	27
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_HUMAN
θ value	θ > 10 (rank : 477)	NC score	0.107894 (rank : 120)
Query Neighborhood Hits	367	Target Neighborhood Hits	341	Shared Neighborhood Hits	44
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 478)	NC score	0.100219 (rank : 126)
Query Neighborhood Hits	367	Target Neighborhood Hits	332	Shared Neighborhood Hits	43
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SHAN1_HUMAN
θ value	θ > 10 (rank : 479)	NC score	0.072004 (rank : 183)
Query Neighborhood Hits	367	Target Neighborhood Hits	1041	Shared Neighborhood Hits	132
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHAN2_MOUSE
θ value	θ > 10 (rank : 480)	NC score	0.071070 (rank : 184)
Query Neighborhood Hits	367	Target Neighborhood Hits	446	Shared Neighborhood Hits	71
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SPTA1_HUMAN
θ value	θ > 10 (rank : 481)	NC score	0.051675 (rank : 300)
Query Neighborhood Hits	367	Target Neighborhood Hits	748	Shared Neighborhood Hits	49
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA1_MOUSE
θ value	θ > 10 (rank : 482)	NC score	0.052055 (rank : 296)
Query Neighborhood Hits	367	Target Neighborhood Hits	675	Shared Neighborhood Hits	44
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
θ value	θ > 10 (rank : 483)	NC score	0.056628 (rank : 265)
Query Neighborhood Hits	367	Target Neighborhood Hits	888	Shared Neighborhood Hits	54
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SRBS1_HUMAN
θ value	θ > 10 (rank : 484)	NC score	0.093058 (rank : 131)
Query Neighborhood Hits	367	Target Neighborhood Hits	396	Shared Neighborhood Hits	48
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 485)	NC score	0.091521 (rank : 134)
Query Neighborhood Hits	367	Target Neighborhood Hits	409	Shared Neighborhood Hits	45
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 486)	NC score	0.066873 (rank : 200)
Query Neighborhood Hits	367	Target Neighborhood Hits	269	Shared Neighborhood Hits	31
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 487)	NC score	0.067115 (rank : 197)
Query Neighborhood Hits	367	Target Neighborhood Hits	292	Shared Neighborhood Hits	37
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRRM1_HUMAN
θ value	θ > 10 (rank : 488)	NC score	0.058843 (rank : 250)
Query Neighborhood Hits	367	Target Neighborhood Hits	690	Shared Neighborhood Hits	113
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

STAC3_HUMAN
θ value	θ > 10 (rank : 489)	NC score	0.068660 (rank : 191)
Query Neighborhood Hits	367	Target Neighborhood Hits	228	Shared Neighborhood Hits	28
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 490)	NC score	0.069181 (rank : 189)
Query Neighborhood Hits	367	Target Neighborhood Hits	232	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 491)	NC score	0.079662 (rank : 159)
Query Neighborhood Hits	367	Target Neighborhood Hits	276	Shared Neighborhood Hits	34
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 492)	NC score	0.077840 (rank : 166)
Query Neighborhood Hits	367	Target Neighborhood Hits	268	Shared Neighborhood Hits	36
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 493)	NC score	0.080978 (rank : 153)
Query Neighborhood Hits	367	Target Neighborhood Hits	271	Shared Neighborhood Hits	34
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 494)	NC score	0.080794 (rank : 155)
Query Neighborhood Hits	367	Target Neighborhood Hits	273	Shared Neighborhood Hits	34
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 495)	NC score	0.077833 (rank : 167)
Query Neighborhood Hits	367	Target Neighborhood Hits	288	Shared Neighborhood Hits	34
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 496)	NC score	0.078352 (rank : 163)
Query Neighborhood Hits	367	Target Neighborhood Hits	285	Shared Neighborhood Hits	31
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

TAF4_HUMAN
θ value	θ > 10 (rank : 497)	NC score	0.065393 (rank : 209)
Query Neighborhood Hits	367	Target Neighborhood Hits	687	Shared Neighborhood Hits	95
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

TARA_HUMAN
θ value	θ > 10 (rank : 498)	NC score	0.051719 (rank : 299)
Query Neighborhood Hits	367	Target Neighborhood Hits	1626	Shared Neighborhood Hits	127
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TCGAP_MOUSE
θ value	θ > 10 (rank : 499)	NC score	0.078052 (rank : 164)
Query Neighborhood Hits	367	Target Neighborhood Hits	409	Shared Neighborhood Hits	73
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

VINEX_HUMAN
θ value	θ > 10 (rank : 500)	NC score	0.085418 (rank : 141)
Query Neighborhood Hits	367	Target Neighborhood Hits	270	Shared Neighborhood Hits	40
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 501)	NC score	0.084011 (rank : 144)
Query Neighborhood Hits	367	Target Neighborhood Hits	286	Shared Neighborhood Hits	33
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

WBP11_HUMAN
θ value	θ > 10 (rank : 502)	NC score	0.058030 (rank : 253)
Query Neighborhood Hits	367	Target Neighborhood Hits	354	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

WBP11_MOUSE
θ value	θ > 10 (rank : 503)	NC score	0.053722 (rank : 281)
Query Neighborhood Hits	367	Target Neighborhood Hits	362	Shared Neighborhood Hits	83
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

WIRE_HUMAN
θ value	θ > 10 (rank : 504)	NC score	0.051375 (rank : 303)
Query Neighborhood Hits	367	Target Neighborhood Hits	329	Shared Neighborhood Hits	81
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

WIRE_MOUSE
θ value	θ > 10 (rank : 505)	NC score	0.050403 (rank : 307)
Query Neighborhood Hits	367	Target Neighborhood Hits	310	Shared Neighborhood Hits	79
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

Hits sorted by NC score

FGD1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	367	Target Neighborhood Hits	367	Shared Neighborhood Hits	367
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
NC score	0.984838 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	367	Target Neighborhood Hits	387	Shared Neighborhood Hits	248
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_MOUSE
NC score	0.957438 (rank : 3)	θ value	1.04765e-165 (rank : 7)
Query Neighborhood Hits	367	Target Neighborhood Hits	163	Shared Neighborhood Hits	130
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD2_HUMAN
NC score	0.957374 (rank : 4)	θ value	1.12192e-159 (rank : 8)
Query Neighborhood Hits	367	Target Neighborhood Hits	151	Shared Neighborhood Hits	128
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD4_HUMAN
NC score	0.954965 (rank : 5)	θ value	1.0077e-184 (rank : 4)
Query Neighborhood Hits	367	Target Neighborhood Hits	219	Shared Neighborhood Hits	137
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
NC score	0.954733 (rank : 6)	θ value	0 (rank : 3)
Query Neighborhood Hits	367	Target Neighborhood Hits	227	Shared Neighborhood Hits	142
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD3_HUMAN
NC score	0.947911 (rank : 7)	θ value	5.01279e-176 (rank : 5)
Query Neighborhood Hits	367	Target Neighborhood Hits	249	Shared Neighborhood Hits	130
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
NC score	0.945251 (rank : 8)	θ value	1.72687e-168 (rank : 6)
Query Neighborhood Hits	367	Target Neighborhood Hits	257	Shared Neighborhood Hits	134
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD6_MOUSE
NC score	0.888108 (rank : 9)	θ value	7.70199e-76 (rank : 9)
Query Neighborhood Hits	367	Target Neighborhood Hits	282	Shared Neighborhood Hits	131
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD6_HUMAN
NC score	0.884692 (rank : 10)	θ value	4.22625e-74 (rank : 10)
Query Neighborhood Hits	367	Target Neighborhood Hits	237	Shared Neighborhood Hits	118
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD5_HUMAN
NC score	0.827711 (rank : 11)	θ value	3.36421e-55 (rank : 11)
Query Neighborhood Hits	367	Target Neighborhood Hits	235	Shared Neighborhood Hits	112
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD5_MOUSE
NC score	0.815693 (rank : 12)	θ value	1.46268e-50 (rank : 12)
Query Neighborhood Hits	367	Target Neighborhood Hits	170	Shared Neighborhood Hits	103
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

ECT2_MOUSE
NC score	0.698381 (rank : 13)	θ value	5.07402e-19 (rank : 19)
Query Neighborhood Hits	367	Target Neighborhood Hits	98	Shared Neighborhood Hits	72
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

PREX1_HUMAN
NC score	0.695196 (rank : 14)	θ value	1.09232e-21 (rank : 16)
Query Neighborhood Hits	367	Target Neighborhood Hits	177	Shared Neighborhood Hits	83
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ECT2_HUMAN
NC score	0.685618 (rank : 15)	θ value	3.28887e-18 (rank : 21)
Query Neighborhood Hits	367	Target Neighborhood Hits	98	Shared Neighborhood Hits	73
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHG5_HUMAN
NC score	0.643028 (rank : 16)	θ value	3.40345e-15 (rank : 26)
Query Neighborhood Hits	367	Target Neighborhood Hits	172	Shared Neighborhood Hits	70
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

PKHG1_HUMAN
NC score	0.641477 (rank : 17)	θ value	3.29651e-10 (rank : 54)
Query Neighborhood Hits	367	Target Neighborhood Hits	174	Shared Neighborhood Hits	74
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

NGEF_HUMAN
NC score	0.633793 (rank : 18)	θ value	3.88503e-19 (rank : 18)
Query Neighborhood Hits	367	Target Neighborhood Hits	166	Shared Neighborhood Hits	74
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PKHF2_HUMAN
NC score	0.623772 (rank : 19)	θ value	2.35696e-16 (rank : 24)
Query Neighborhood Hits	367	Target Neighborhood Hits	75	Shared Neighborhood Hits	61
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

ARHGG_HUMAN
NC score	0.623624 (rank : 20)	θ value	1.09485e-13 (rank : 28)
Query Neighborhood Hits	367	Target Neighborhood Hits	129	Shared Neighborhood Hits	68
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

PKHF2_MOUSE
NC score	0.623435 (rank : 21)	θ value	1.80466e-16 (rank : 23)
Query Neighborhood Hits	367	Target Neighborhood Hits	77	Shared Neighborhood Hits	61
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

NGEF_MOUSE
NC score	0.623099 (rank : 22)	θ value	1.13037e-18 (rank : 20)
Query Neighborhood Hits	367	Target Neighborhood Hits	228	Shared Neighborhood Hits	76
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHG4_MOUSE
NC score	0.622742 (rank : 23)	θ value	4.91457e-14 (rank : 27)
Query Neighborhood Hits	367	Target Neighborhood Hits	185	Shared Neighborhood Hits	76
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_HUMAN
NC score	0.612799 (rank : 24)	θ value	8.10077e-17 (rank : 22)
Query Neighborhood Hits	367	Target Neighborhood Hits	242	Shared Neighborhood Hits	77
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PKHF1_HUMAN
NC score	0.608290 (rank : 25)	θ value	3.52202e-12 (rank : 35)
Query Neighborhood Hits	367	Target Neighborhood Hits	76	Shared Neighborhood Hits	60
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
NC score	0.604669 (rank : 26)	θ value	6.00763e-12 (rank : 39)
Query Neighborhood Hits	367	Target Neighborhood Hits	80	Shared Neighborhood Hits	61
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

ARHGG_MOUSE
NC score	0.601700 (rank : 27)	θ value	4.59992e-12 (rank : 36)
Query Neighborhood Hits	367	Target Neighborhood Hits	152	Shared Neighborhood Hits	71
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG9_HUMAN
NC score	0.592309 (rank : 28)	θ value	1.86753e-13 (rank : 29)
Query Neighborhood Hits	367	Target Neighborhood Hits	235	Shared Neighborhood Hits	79
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHGF_HUMAN
NC score	0.591759 (rank : 29)	θ value	1.86753e-13 (rank : 30)
Query Neighborhood Hits	367	Target Neighborhood Hits	214	Shared Neighborhood Hits	108
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHG9_MOUSE
NC score	0.590632 (rank : 30)	θ value	2.43908e-13 (rank : 31)
Query Neighborhood Hits	367	Target Neighborhood Hits	234	Shared Neighborhood Hits	79
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

FARP2_MOUSE
NC score	0.574343 (rank : 31)	θ value	2.19075e-38 (rank : 13)
Query Neighborhood Hits	367	Target Neighborhood Hits	209	Shared Neighborhood Hits	96
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ARHGA_HUMAN
NC score	0.564241 (rank : 32)	θ value	8.11959e-09 (rank : 61)
Query Neighborhood Hits	367	Target Neighborhood Hits	187	Shared Neighborhood Hits	66
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

MCF2_HUMAN
NC score	0.560657 (rank : 33)	θ value	1.17247e-07 (rank : 70)
Query Neighborhood Hits	367	Target Neighborhood Hits	166	Shared Neighborhood Hits	74
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ARHG2_MOUSE
NC score	0.560098 (rank : 34)	θ value	8.67504e-11 (rank : 47)
Query Neighborhood Hits	367	Target Neighborhood Hits	120	Shared Neighborhood Hits	66
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHGA_MOUSE
NC score	0.559648 (rank : 35)	θ value	2.13673e-09 (rank : 60)
Query Neighborhood Hits	367	Target Neighborhood Hits	125	Shared Neighborhood Hits	70
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

FARP2_HUMAN
NC score	0.558136 (rank : 36)	θ value	8.32485e-38 (rank : 14)
Query Neighborhood Hits	367	Target Neighborhood Hits	240	Shared Neighborhood Hits	101
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

TIAM1_MOUSE
NC score	0.535634 (rank : 37)	θ value	5.26297e-08 (rank : 65)
Query Neighborhood Hits	367	Target Neighborhood Hits	205	Shared Neighborhood Hits	75
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_HUMAN
NC score	0.535341 (rank : 38)	θ value	1.25267e-09 (rank : 58)
Query Neighborhood Hits	367	Target Neighborhood Hits	225	Shared Neighborhood Hits	77
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG1_HUMAN
NC score	0.534173 (rank : 39)	θ value	8.97725e-08 (rank : 68)
Query Neighborhood Hits	367	Target Neighborhood Hits	176	Shared Neighborhood Hits	87
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

MCF2L_MOUSE
NC score	0.529783 (rank : 40)	θ value	8.11959e-09 (rank : 62)
Query Neighborhood Hits	367	Target Neighborhood Hits	255	Shared Neighborhood Hits	79
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

FARP1_HUMAN
NC score	0.528772 (rank : 41)	θ value	4.72714e-33 (rank : 15)
Query Neighborhood Hits	367	Target Neighborhood Hits	241	Shared Neighborhood Hits	94
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

LBC_HUMAN
NC score	0.523024 (rank : 42)	θ value	1.47974e-10 (rank : 51)
Query Neighborhood Hits	367	Target Neighborhood Hits	90	Shared Neighborhood Hits	58
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHG1_MOUSE
NC score	0.514783 (rank : 43)	θ value	1.38499e-08 (rank : 63)
Query Neighborhood Hits	367	Target Neighborhood Hits	266	Shared Neighborhood Hits	95
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHGB_HUMAN
NC score	0.514281 (rank : 44)	θ value	1.9326e-10 (rank : 52)
Query Neighborhood Hits	367	Target Neighborhood Hits	375	Shared Neighborhood Hits	85
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHG2_HUMAN
NC score	0.507441 (rank : 45)	θ value	1.63604e-09 (rank : 59)
Query Neighborhood Hits	367	Target Neighborhood Hits	142	Shared Neighborhood Hits	68
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

HAPIP_HUMAN
NC score	0.505164 (rank : 46)	θ value	1.2105e-12 (rank : 32)
Query Neighborhood Hits	367	Target Neighborhood Hits	350	Shared Neighborhood Hits	82
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ARHG3_MOUSE
NC score	0.498052 (rank : 47)	θ value	9.29e-05 (rank : 95)
Query Neighborhood Hits	367	Target Neighborhood Hits	85	Shared Neighborhood Hits	64
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG3_HUMAN
NC score	0.497151 (rank : 48)	θ value	5.44631e-05 (rank : 93)
Query Neighborhood Hits	367	Target Neighborhood Hits	82	Shared Neighborhood Hits	64
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

GNRP_MOUSE
NC score	0.494212 (rank : 49)	θ value	1.133e-10 (rank : 50)
Query Neighborhood Hits	367	Target Neighborhood Hits	191	Shared Neighborhood Hits	75
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ARHGC_HUMAN
NC score	0.490425 (rank : 50)	θ value	6.64225e-11 (rank : 46)
Query Neighborhood Hits	367	Target Neighborhood Hits	351	Shared Neighborhood Hits	75
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
NC score	0.489087 (rank : 51)	θ value	8.67504e-11 (rank : 48)
Query Neighborhood Hits	367	Target Neighborhood Hits	344	Shared Neighborhood Hits	72
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHG8_HUMAN
NC score	0.487819 (rank : 52)	θ value	0.0563607 (rank : 134)
Query Neighborhood Hits	367	Target Neighborhood Hits	85	Shared Neighborhood Hits	72
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ZFY28_HUMAN
NC score	0.484451 (rank : 53)	θ value	5.26297e-08 (rank : 66)
Query Neighborhood Hits	367	Target Neighborhood Hits	152	Shared Neighborhood Hits	60
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV9_HUMAN
NC score	0.480035 (rank : 54)	θ value	1.74796e-11 (rank : 43)
Query Neighborhood Hits	367	Target Neighborhood Hits	134	Shared Neighborhood Hits	51
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

PKHG4_HUMAN
NC score	0.475028 (rank : 55)	θ value	0.000602161 (rank : 102)
Query Neighborhood Hits	367	Target Neighborhood Hits	200	Shared Neighborhood Hits	71
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

ZFY16_MOUSE
NC score	0.468496 (rank : 56)	θ value	2.69671e-12 (rank : 34)
Query Neighborhood Hits	367	Target Neighborhood Hits	108	Shared Neighborhood Hits	51
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

GNRP_HUMAN
NC score	0.463663 (rank : 57)	θ value	5.62301e-10 (rank : 56)
Query Neighborhood Hits	367	Target Neighborhood Hits	239	Shared Neighborhood Hits	78
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

ZFY16_HUMAN
NC score	0.458899 (rank : 58)	θ value	5.08577e-11 (rank : 45)
Query Neighborhood Hits	367	Target Neighborhood Hits	125	Shared Neighborhood Hits	50
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY21_MOUSE
NC score	0.456304 (rank : 59)	θ value	7.1131e-05 (rank : 94)
Query Neighborhood Hits	367	Target Neighborhood Hits	72	Shared Neighborhood Hits	51
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_HUMAN
NC score	0.447561 (rank : 60)	θ value	0.000602161 (rank : 103)
Query Neighborhood Hits	367	Target Neighborhood Hits	72	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ARHG7_HUMAN
NC score	0.441305 (rank : 61)	θ value	2.69671e-12 (rank : 33)
Query Neighborhood Hits	367	Target Neighborhood Hits	347	Shared Neighborhood Hits	85
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

VAV_MOUSE
NC score	0.435416 (rank : 62)	θ value	6.00763e-12 (rank : 40)
Query Neighborhood Hits	367	Target Neighborhood Hits	430	Shared Neighborhood Hits	81
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV_HUMAN
NC score	0.428347 (rank : 63)	θ value	4.59992e-12 (rank : 38)
Query Neighborhood Hits	367	Target Neighborhood Hits	452	Shared Neighborhood Hits	82
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV2_MOUSE
NC score	0.421071 (rank : 64)	θ value	1.69304e-06 (rank : 82)
Query Neighborhood Hits	367	Target Neighborhood Hits	456	Shared Neighborhood Hits	100
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ARHG7_MOUSE
NC score	0.420581 (rank : 65)	θ value	1.25267e-09 (rank : 57)
Query Neighborhood Hits	367	Target Neighborhood Hits	396	Shared Neighborhood Hits	81
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

DNMBP_MOUSE
NC score	0.418095 (rank : 66)	θ value	7.59969e-07 (rank : 77)
Query Neighborhood Hits	367	Target Neighborhood Hits	435	Shared Neighborhood Hits	89
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

VAV2_HUMAN
NC score	0.415676 (rank : 67)	θ value	7.59969e-07 (rank : 78)
Query Neighborhood Hits	367	Target Neighborhood Hits	453	Shared Neighborhood Hits	95
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ARHG8_MOUSE
NC score	0.415321 (rank : 68)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	367	Target Neighborhood Hits	79	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

VAV3_MOUSE
NC score	0.414129 (rank : 69)	θ value	3.29651e-10 (rank : 55)
Query Neighborhood Hits	367	Target Neighborhood Hits	404	Shared Neighborhood Hits	88
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

BCR_HUMAN
NC score	0.411898 (rank : 70)	θ value	7.84624e-12 (rank : 41)
Query Neighborhood Hits	367	Target Neighborhood Hits	204	Shared Neighborhood Hits	74
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ABR_HUMAN
NC score	0.410909 (rank : 71)	θ value	1.74796e-11 (rank : 42)
Query Neighborhood Hits	367	Target Neighborhood Hits	166	Shared Neighborhood Hits	67
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

VAV3_HUMAN
NC score	0.410871 (rank : 72)	θ value	1.38499e-08 (rank : 64)
Query Neighborhood Hits	367	Target Neighborhood Hits	398	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

RGNEF_MOUSE
NC score	0.408339 (rank : 73)	θ value	6.87365e-08 (rank : 67)
Query Neighborhood Hits	367	Target Neighborhood Hits	641	Shared Neighborhood Hits	88
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ITSN2_HUMAN
NC score	0.401641 (rank : 74)	θ value	1.9326e-10 (rank : 53)
Query Neighborhood Hits	367	Target Neighborhood Hits	1173	Shared Neighborhood Hits	112
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

DNMBP_HUMAN
NC score	0.398417 (rank : 75)	θ value	1.09739e-05 (rank : 85)
Query Neighborhood Hits	367	Target Neighborhood Hits	413	Shared Neighborhood Hits	91
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ITSN2_MOUSE
NC score	0.381377 (rank : 76)	θ value	8.67504e-11 (rank : 49)
Query Neighborhood Hits	367	Target Neighborhood Hits	1371	Shared Neighborhood Hits	114
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ITSN1_HUMAN
NC score	0.375805 (rank : 77)	θ value	4.59992e-12 (rank : 37)
Query Neighborhood Hits	367	Target Neighborhood Hits	1757	Shared Neighborhood Hits	147
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.375714 (rank : 78)	θ value	2.28291e-11 (rank : 44)
Query Neighborhood Hits	367	Target Neighborhood Hits	1669	Shared Neighborhood Hits	141
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

HGS_MOUSE
NC score	0.375270 (rank : 79)	θ value	1.17247e-07 (rank : 69)
Query Neighborhood Hits	367	Target Neighborhood Hits	589	Shared Neighborhood Hits	107
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

HGS_HUMAN
NC score	0.372976 (rank : 80)	θ value	1.99992e-07 (rank : 71)
Query Neighborhood Hits	367	Target Neighborhood Hits	517	Shared Neighborhood Hits	93
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

ARHG6_HUMAN
NC score	0.353132 (rank : 81)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	367	Target Neighborhood Hits	376	Shared Neighborhood Hits	74
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

RBNS5_HUMAN
NC score	0.348812 (rank : 82)	θ value	0.00035302 (rank : 99)
Query Neighborhood Hits	367	Target Neighborhood Hits	242	Shared Neighborhood Hits	69
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
NC score	0.339882 (rank : 83)	θ value	0.000461057 (rank : 100)
Query Neighborhood Hits	367	Target Neighborhood Hits	266	Shared Neighborhood Hits	61
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

ZFYV1_HUMAN
NC score	0.332326 (rank : 84)	θ value	0.00390308 (rank : 115)
Query Neighborhood Hits	367	Target Neighborhood Hits	166	Shared Neighborhood Hits	55
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
NC score	0.328665 (rank : 85)	θ value	0.00665767 (rank : 117)
Query Neighborhood Hits	367	Target Neighborhood Hits	153	Shared Neighborhood Hits	54
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

ZFY19_HUMAN
NC score	0.323342 (rank : 86)	θ value	0.000270298 (rank : 97)
Query Neighborhood Hits	367	Target Neighborhood Hits	206	Shared Neighborhood Hits	52
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ARHG6_MOUSE
NC score	0.322606 (rank : 87)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	367	Target Neighborhood Hits	394	Shared Neighborhood Hits	75
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ZFY19_MOUSE
NC score	0.314840 (rank : 88)	θ value	0.00175202 (rank : 109)
Query Neighborhood Hits	367	Target Neighborhood Hits	143	Shared Neighborhood Hits	55
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

SOS2_HUMAN
NC score	0.301433 (rank : 89)	θ value	1.87187e-05 (rank : 88)
Query Neighborhood Hits	367	Target Neighborhood Hits	193	Shared Neighborhood Hits	65
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SOS1_HUMAN
NC score	0.296791 (rank : 90)	θ value	1.87187e-05 (rank : 87)
Query Neighborhood Hits	367	Target Neighborhood Hits	274	Shared Neighborhood Hits	78
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

FYV1_HUMAN
NC score	0.287545 (rank : 91)	θ value	0.0148317 (rank : 123)
Query Neighborhood Hits	367	Target Neighborhood Hits	217	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
NC score	0.284492 (rank : 92)	θ value	0.0148317 (rank : 124)
Query Neighborhood Hits	367	Target Neighborhood Hits	191	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

SOS1_MOUSE
NC score	0.276676 (rank : 93)	θ value	0.00102713 (rank : 105)
Query Neighborhood Hits	367	Target Neighborhood Hits	281	Shared Neighborhood Hits	73
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

WDFY1_HUMAN
NC score	0.276258 (rank : 94)	θ value	1.43324e-05 (rank : 86)
Query Neighborhood Hits	367	Target Neighborhood Hits	305	Shared Neighborhood Hits	49
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

RUFY2_MOUSE
NC score	0.265160 (rank : 95)	θ value	1.29631e-06 (rank : 80)
Query Neighborhood Hits	367	Target Neighborhood Hits	820	Shared Neighborhood Hits	79
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

WDFY3_HUMAN
NC score	0.260916 (rank : 96)	θ value	3.77169e-06 (rank : 83)
Query Neighborhood Hits	367	Target Neighborhood Hits	348	Shared Neighborhood Hits	57
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY3_MOUSE
NC score	0.260910 (rank : 97)	θ value	3.77169e-06 (rank : 84)
Query Neighborhood Hits	367	Target Neighborhood Hits	332	Shared Neighborhood Hits	56
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

RUFY1_MOUSE
NC score	0.260629 (rank : 98)	θ value	1.99992e-07 (rank : 72)
Query Neighborhood Hits	367	Target Neighborhood Hits	765	Shared Neighborhood Hits	77
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY1_HUMAN
NC score	0.256928 (rank : 99)	θ value	5.81887e-07 (rank : 75)
Query Neighborhood Hits	367	Target Neighborhood Hits	848	Shared Neighborhood Hits	81
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

WDFY2_MOUSE
NC score	0.255791 (rank : 100)	θ value	4.1701e-05 (rank : 92)
Query Neighborhood Hits	367	Target Neighborhood Hits	337	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

WDFY2_HUMAN
NC score	0.254078 (rank : 101)	θ value	4.1701e-05 (rank : 91)
Query Neighborhood Hits	367	Target Neighborhood Hits	332	Shared Neighborhood Hits	48
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

MTMR3_HUMAN
NC score	0.242349 (rank : 102)	θ value	0.000786445 (rank : 104)
Query Neighborhood Hits	367	Target Neighborhood Hits	163	Shared Neighborhood Hits	58
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

PKHA6_HUMAN
NC score	0.219776 (rank : 103)	θ value	9.92553e-07 (rank : 79)
Query Neighborhood Hits	367	Target Neighborhood Hits	556	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

RUFY2_HUMAN
NC score	0.218976 (rank : 104)	θ value	5.81887e-07 (rank : 76)
Query Neighborhood Hits	367	Target Neighborhood Hits	1208	Shared Neighborhood Hits	87
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

PKHA6_MOUSE
NC score	0.216399 (rank : 105)	θ value	1.69304e-06 (rank : 81)
Query Neighborhood Hits	367	Target Neighborhood Hits	591	Shared Neighborhood Hits	95
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

DUET_HUMAN
NC score	0.215759 (rank : 106)	θ value	2.43343e-21 (rank : 17)
Query Neighborhood Hits	367	Target Neighborhood Hits	1220	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

TRIO_HUMAN
NC score	0.205796 (rank : 107)	θ value	5.25075e-16 (rank : 25)
Query Neighborhood Hits	367	Target Neighborhood Hits	1580	Shared Neighborhood Hits	124
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

ZFY27_MOUSE
NC score	0.196780 (rank : 108)	θ value	0.0961366 (rank : 147)
Query Neighborhood Hits	367	Target Neighborhood Hits	53	Shared Neighborhood Hits	42
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

ZFY27_HUMAN
NC score	0.187376 (rank : 109)	θ value	0.47712 (rank : 189)
Query Neighborhood Hits	367	Target Neighborhood Hits	64	Shared Neighborhood Hits	42
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

FYCO1_HUMAN
NC score	0.179868 (rank : 110)	θ value	0.00035302 (rank : 98)
Query Neighborhood Hits	367	Target Neighborhood Hits	1149	Shared Neighborhood Hits	88
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

ANFY1_MOUSE
NC score	0.175006 (rank : 111)	θ value	2.44474e-05 (rank : 89)
Query Neighborhood Hits	367	Target Neighborhood Hits	480	Shared Neighborhood Hits	64
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_HUMAN
NC score	0.174871 (rank : 112)	θ value	3.19293e-05 (rank : 90)
Query Neighborhood Hits	367	Target Neighborhood Hits	480	Shared Neighborhood Hits	64
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

EEA1_MOUSE
NC score	0.174803 (rank : 113)	θ value	5.81887e-07 (rank : 74)
Query Neighborhood Hits	367	Target Neighborhood Hits	1637	Shared Neighborhood Hits	99
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

FYCO1_MOUSE
NC score	0.164919 (rank : 114)	θ value	0.00134147 (rank : 107)
Query Neighborhood Hits	367	Target Neighborhood Hits	1059	Shared Neighborhood Hits	88
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

EEA1_HUMAN
NC score	0.162091 (rank : 115)	θ value	4.45536e-07 (rank : 73)
Query Neighborhood Hits	367	Target Neighborhood Hits	1796	Shared Neighborhood Hits	98
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

PKHA4_HUMAN
NC score	0.160238 (rank : 116)	θ value	0.0193708 (rank : 129)
Query Neighborhood Hits	367	Target Neighborhood Hits	283	Shared Neighborhood Hits	75
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_MOUSE
NC score	0.154671 (rank : 117)	θ value	0.0252991 (rank : 130)
Query Neighborhood Hits	367	Target Neighborhood Hits	202	Shared Neighborhood Hits	47
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA5_HUMAN
NC score	0.142190 (rank : 118)	θ value	0.163984 (rank : 148)
Query Neighborhood Hits	367	Target Neighborhood Hits	455	Shared Neighborhood Hits	52
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

ALS2_MOUSE
NC score	0.123219 (rank : 119)	θ value	0.21417 (rank : 154)
Query Neighborhood Hits	367	Target Neighborhood Hits	111	Shared Neighborhood Hits	26
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

SH3K1_HUMAN
NC score	0.107894 (rank : 120)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	367	Target Neighborhood Hits	341	Shared Neighborhood Hits	44
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

NCF1_HUMAN
NC score	0.107137 (rank : 121)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	367	Target Neighborhood Hits	198	Shared Neighborhood Hits	33
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

ALS2_HUMAN
NC score	0.103744 (rank : 122)	θ value	1.81305 (rank : 231)
Query Neighborhood Hits	367	Target Neighborhood Hits	121	Shared Neighborhood Hits	26
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

DGKH_HUMAN
NC score	0.102543 (rank : 123)	θ value	0.000602161 (rank : 101)
Query Neighborhood Hits	367	Target Neighborhood Hits	255	Shared Neighborhood Hits	50
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

CD2AP_HUMAN
NC score	0.101916 (rank : 124)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	367	Target Neighborhood Hits	315	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
NC score	0.101322 (rank : 125)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	367	Target Neighborhood Hits	336	Shared Neighborhood Hits	55
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

SH3K1_MOUSE
NC score	0.100219 (rank : 126)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	367	Target Neighborhood Hits	332	Shared Neighborhood Hits	43
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

NCF1_MOUSE
NC score	0.099600 (rank : 127)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	367	Target Neighborhood Hits	198	Shared Neighborhood Hits	31
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

OBSCN_HUMAN
NC score	0.098222 (rank : 128)	θ value	0.00175202 (rank : 108)
Query Neighborhood Hits	367	Target Neighborhood Hits	1931	Shared Neighborhood Hits	133
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

DGKK_HUMAN
NC score	0.096455 (rank : 129)	θ value	0.21417 (rank : 156)
Query Neighborhood Hits	367	Target Neighborhood Hits	378	Shared Neighborhood Hits	85
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

SWP70_HUMAN
NC score	0.095276 (rank : 130)	θ value	0.0563607 (rank : 136)
Query Neighborhood Hits	367	Target Neighborhood Hits	973	Shared Neighborhood Hits	64
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SRBS1_HUMAN
NC score	0.093058 (rank : 131)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	367	Target Neighborhood Hits	396	Shared Neighborhood Hits	48
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

3BP2_HUMAN
NC score	0.092333 (rank : 132)	θ value	0.47712 (rank : 181)
Query Neighborhood Hits	367	Target Neighborhood Hits	296	Shared Neighborhood Hits	56
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

SWP70_MOUSE
NC score	0.092160 (rank : 133)	θ value	0.0736092 (rank : 141)
Query Neighborhood Hits	367	Target Neighborhood Hits	1097	Shared Neighborhood Hits	69
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SRBS1_MOUSE
NC score	0.091521 (rank : 134)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	367	Target Neighborhood Hits	409	Shared Neighborhood Hits	45
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

MELPH_MOUSE
NC score	0.090728 (rank : 135)	θ value	0.47712 (rank : 184)
Query Neighborhood Hits	367	Target Neighborhood Hits	112	Shared Neighborhood Hits	22
SwissProt Accessions	Q91V27, Q99N53	Gene names	Mlph, Ln, Slac2a
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Leaden protein) (Synaptotagmin-like protein 2a) (Slac2-a) (Slp homolog lacking C2 domains a).

WASIP_MOUSE
NC score	0.090213 (rank : 136)	θ value	0.0736092 (rank : 142)
Query Neighborhood Hits	367	Target Neighborhood Hits	392	Shared Neighborhood Hits	97
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

NCF2_HUMAN
NC score	0.089654 (rank : 137)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	367	Target Neighborhood Hits	229	Shared Neighborhood Hits	30
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

WASIP_HUMAN
NC score	0.088217 (rank : 138)	θ value	0.813845 (rank : 209)
Query Neighborhood Hits	367	Target Neighborhood Hits	458	Shared Neighborhood Hits	105
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

CNKR1_HUMAN
NC score	0.087899 (rank : 139)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	367	Target Neighborhood Hits	154	Shared Neighborhood Hits	42
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

TCGAP_HUMAN
NC score	0.086431 (rank : 140)	θ value	0.00509761 (rank : 116)
Query Neighborhood Hits	367	Target Neighborhood Hits	872	Shared Neighborhood Hits	111
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

VINEX_HUMAN
NC score	0.085418 (rank : 141)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	367	Target Neighborhood Hits	270	Shared Neighborhood Hits	40
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

PRR12_HUMAN
NC score	0.084947 (rank : 142)	θ value	5.27518 (rank : 301)
Query Neighborhood Hits	367	Target Neighborhood Hits	460	Shared Neighborhood Hits	99
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

NCK1_HUMAN
NC score	0.084176 (rank : 143)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	367	Target Neighborhood Hits	312	Shared Neighborhood Hits	36
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

VINEX_MOUSE
NC score	0.084011 (rank : 144)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	367	Target Neighborhood Hits	286	Shared Neighborhood Hits	33
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

RGS3_MOUSE
NC score	0.083492 (rank : 145)	θ value	0.000158464 (rank : 96)
Query Neighborhood Hits	367	Target Neighborhood Hits	1621	Shared Neighborhood Hits	150
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

GRAP_HUMAN
NC score	0.083403 (rank : 146)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	367	Target Neighborhood Hits	307	Shared Neighborhood Hits	35
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

PRP2_MOUSE
NC score	0.082441 (rank : 147)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	367	Target Neighborhood Hits	347	Shared Neighborhood Hits	87
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

3BP2_MOUSE
NC score	0.082388 (rank : 148)	θ value	3.0926 (rank : 257)
Query Neighborhood Hits	367	Target Neighborhood Hits	142	Shared Neighborhood Hits	39
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

DGKD_HUMAN
NC score	0.082320 (rank : 149)	θ value	0.00298849 (rank : 111)
Query Neighborhood Hits	367	Target Neighborhood Hits	231	Shared Neighborhood Hits	35
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

MYRIP_MOUSE
NC score	0.081843 (rank : 150)	θ value	0.62314 (rank : 194)
Query Neighborhood Hits	367	Target Neighborhood Hits	207	Shared Neighborhood Hits	30
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

NCK2_HUMAN
NC score	0.081831 (rank : 151)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	367	Target Neighborhood Hits	310	Shared Neighborhood Hits	38
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

GRAP_MOUSE
NC score	0.081029 (rank : 152)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	367	Target Neighborhood Hits	309	Shared Neighborhood Hits	34
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

STAM1_HUMAN
NC score	0.080978 (rank : 153)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	367	Target Neighborhood Hits	271	Shared Neighborhood Hits	34
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

EFS_MOUSE
NC score	0.080932 (rank : 154)	θ value	0.365318 (rank : 175)
Query Neighborhood Hits	367	Target Neighborhood Hits	389	Shared Neighborhood Hits	55
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

STAM1_MOUSE
NC score	0.080794 (rank : 155)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	367	Target Neighborhood Hits	273	Shared Neighborhood Hits	34
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

BCAR1_HUMAN
NC score	0.080493 (rank : 156)	θ value	1.06291 (rank : 212)
Query Neighborhood Hits	367	Target Neighborhood Hits	554	Shared Neighborhood Hits	90
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
NC score	0.080449 (rank : 157)	θ value	0.279714 (rank : 161)
Query Neighborhood Hits	367	Target Neighborhood Hits	438	Shared Neighborhood Hits	77
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

PKHA2_MOUSE
NC score	0.079756 (rank : 158)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	367	Target Neighborhood Hits	116	Shared Neighborhood Hits	38
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

STAC_HUMAN
NC score	0.079662 (rank : 159)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	367	Target Neighborhood Hits	276	Shared Neighborhood Hits	34
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

OSBL9_HUMAN
NC score	0.079655 (rank : 160)	θ value	0.0193708 (rank : 128)
Query Neighborhood Hits	367	Target Neighborhood Hits	138	Shared Neighborhood Hits	29
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

BSN_HUMAN
NC score	0.079410 (rank : 161)	θ value	0.21417 (rank : 155)
Query Neighborhood Hits	367	Target Neighborhood Hits	1537	Shared Neighborhood Hits	150
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

NCOA6_HUMAN
NC score	0.079093 (rank : 162)	θ value	0.00298849 (rank : 112)
Query Neighborhood Hits	367	Target Neighborhood Hits	1202	Shared Neighborhood Hits	133
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

STAM2_MOUSE
NC score	0.078352 (rank : 163)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	367	Target Neighborhood Hits	285	Shared Neighborhood Hits	31
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

TCGAP_MOUSE
NC score	0.078052 (rank : 164)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	367	Target Neighborhood Hits	409	Shared Neighborhood Hits	73
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

OGFR_HUMAN
NC score	0.077978 (rank : 165)	θ value	0.0193708 (rank : 127)
Query Neighborhood Hits	367	Target Neighborhood Hits	1582	Shared Neighborhood Hits	141
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

STAC_MOUSE
NC score	0.077840 (rank : 166)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	367	Target Neighborhood Hits	268	Shared Neighborhood Hits	36
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM2_HUMAN
NC score	0.077833 (rank : 167)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	367	Target Neighborhood Hits	288	Shared Neighborhood Hits	34
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

NCF4_MOUSE
NC score	0.077760 (rank : 168)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	367	Target Neighborhood Hits	177	Shared Neighborhood Hits	24
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

BSN_MOUSE
NC score	0.077319 (rank : 169)	θ value	1.38821 (rank : 219)
Query Neighborhood Hits	367	Target Neighborhood Hits	2057	Shared Neighborhood Hits	173
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

NCF4_HUMAN
NC score	0.076769 (rank : 170)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	367	Target Neighborhood Hits	161	Shared Neighborhood Hits	21
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

MELPH_HUMAN
NC score	0.076431 (rank : 171)	θ value	0.365318 (rank : 177)
Query Neighborhood Hits	367	Target Neighborhood Hits	145	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BV36, Q9HA71	Gene names	MLPH, SLAC2A
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Synaptotagmin-like protein 2a) (Slp homolog lacking C2 domains a).

ABI2_HUMAN
NC score	0.074727 (rank : 172)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	367	Target Neighborhood Hits	350	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

IASPP_MOUSE
NC score	0.074435 (rank : 173)	θ value	1.06291 (rank : 214)
Query Neighborhood Hits	367	Target Neighborhood Hits	1024	Shared Neighborhood Hits	129
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

HCLS1_MOUSE
NC score	0.073893 (rank : 174)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	367	Target Neighborhood Hits	329	Shared Neighborhood Hits	52
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

CNKR2_MOUSE
NC score	0.073614 (rank : 175)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	367	Target Neighborhood Hits	197	Shared Neighborhood Hits	34
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.073306 (rank : 176)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	367	Target Neighborhood Hits	197	Shared Neighborhood Hits	34
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

HCLS1_HUMAN
NC score	0.073066 (rank : 177)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	367	Target Neighborhood Hits	358	Shared Neighborhood Hits	54
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

PCLO_HUMAN
NC score	0.072873 (rank : 178)	θ value	0.47712 (rank : 186)
Query Neighborhood Hits	367	Target Neighborhood Hits	2046	Shared Neighborhood Hits	172
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

ASPP1_MOUSE
NC score	0.072555 (rank : 179)	θ value	0.365318 (rank : 172)
Query Neighborhood Hits	367	Target Neighborhood Hits	1244	Shared Neighborhood Hits	122
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

GRB2_HUMAN
NC score	0.072504 (rank : 180)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	367	Target Neighborhood Hits	310	Shared Neighborhood Hits	32
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.072503 (rank : 181)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	367	Target Neighborhood Hits	312	Shared Neighborhood Hits	32
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

PKHA2_HUMAN
NC score	0.072440 (rank : 182)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	367	Target Neighborhood Hits	119	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

SHAN1_HUMAN
NC score	0.072004 (rank : 183)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	367	Target Neighborhood Hits	1041	Shared Neighborhood Hits	132
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHAN2_MOUSE
NC score	0.071070 (rank : 184)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	367	Target Neighborhood Hits	446	Shared Neighborhood Hits	71
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

PRP1_HUMAN
NC score	0.070641 (rank : 185)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	367	Target Neighborhood Hits	385	Shared Neighborhood Hits	99
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

TARSH_HUMAN
NC score	0.070600 (rank : 186)	θ value	0.163984 (rank : 151)
Query Neighborhood Hits	367	Target Neighborhood Hits	768	Shared Neighborhood Hits	87
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

PRB4S_HUMAN
NC score	0.069901 (rank : 187)	θ value	8.99809 (rank : 358)
Query Neighborhood Hits	367	Target Neighborhood Hits	330	Shared Neighborhood Hits	84
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

PPIP1_HUMAN
NC score	0.069590 (rank : 188)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	367	Target Neighborhood Hits	389	Shared Neighborhood Hits	38
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

STAC3_MOUSE
NC score	0.069181 (rank : 189)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	367	Target Neighborhood Hits	232	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

CENB5_HUMAN
NC score	0.068676 (rank : 190)	θ value	0.00869519 (rank : 118)
Query Neighborhood Hits	367	Target Neighborhood Hits	395	Shared Neighborhood Hits	44
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

STAC3_HUMAN
NC score	0.068660 (rank : 191)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	367	Target Neighborhood Hits	228	Shared Neighborhood Hits	28
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ABI2_MOUSE
NC score	0.068475 (rank : 192)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	367	Target Neighborhood Hits	266	Shared Neighborhood Hits	41
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

IASPP_HUMAN
NC score	0.067401 (rank : 193)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	367	Target Neighborhood Hits	688	Shared Neighborhood Hits	109
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

GRAP2_HUMAN
NC score	0.067329 (rank : 194)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	367	Target Neighborhood Hits	304	Shared Neighborhood Hits	31
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

BI2L1_HUMAN
NC score	0.067142 (rank : 195)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	367	Target Neighborhood Hits	156	Shared Neighborhood Hits	32
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

MLL2_HUMAN
NC score	0.067132 (rank : 196)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	367	Target Neighborhood Hits	1788	Shared Neighborhood Hits	178
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

SRC8_MOUSE
NC score	0.067115 (rank : 197)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	367	Target Neighborhood Hits	292	Shared Neighborhood Hits	37
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

PPIP1_MOUSE
NC score	0.066988 (rank : 198)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	367	Target Neighborhood Hits	377	Shared Neighborhood Hits	40
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

EFS_HUMAN
NC score	0.066963 (rank : 199)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	367	Target Neighborhood Hits	348	Shared Neighborhood Hits	64
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

SRC8_HUMAN
NC score	0.066873 (rank : 200)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	367	Target Neighborhood Hits	269	Shared Neighborhood Hits	31
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

PRRT3_HUMAN
NC score	0.066698 (rank : 201)	θ value	0.279714 (rank : 169)
Query Neighborhood Hits	367	Target Neighborhood Hits	998	Shared Neighborhood Hits	121
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

DDEF2_MOUSE
NC score	0.066623 (rank : 202)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	367	Target Neighborhood Hits	625	Shared Neighborhood Hits	96
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

GRAP2_MOUSE
NC score	0.066488 (rank : 203)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	367	Target Neighborhood Hits	297	Shared Neighborhood Hits	28
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

ABI1_MOUSE
NC score	0.066450 (rank : 204)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	367	Target Neighborhood Hits	246	Shared Neighborhood Hits	43
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

PCLO_MOUSE
NC score	0.066275 (rank : 205)	θ value	0.279714 (rank : 167)
Query Neighborhood Hits	367	Target Neighborhood Hits	2275	Shared Neighborhood Hits	182
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

CENB2_HUMAN
NC score	0.066272 (rank : 206)	θ value	0.0431538 (rank : 132)
Query Neighborhood Hits	367	Target Neighborhood Hits	425	Shared Neighborhood Hits	44
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

MYRIP_HUMAN
NC score	0.066262 (rank : 207)	θ value	1.81305 (rank : 237)
Query Neighborhood Hits	367	Target Neighborhood Hits	269	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

DDEF2_HUMAN
NC score	0.065851 (rank : 208)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	367	Target Neighborhood Hits	599	Shared Neighborhood Hits	92
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

TAF4_HUMAN
NC score	0.065393 (rank : 209)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	367	Target Neighborhood Hits	687	Shared Neighborhood Hits	95
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

SRRM1_MOUSE
NC score	0.065384 (rank : 210)	θ value	2.36792 (rank : 254)
Query Neighborhood Hits	367	Target Neighborhood Hits	966	Shared Neighborhood Hits	124
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

CYH3_MOUSE
NC score	0.065310 (rank : 211)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	367	Target Neighborhood Hits	148	Shared Neighborhood Hits	39
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

RUFY3_MOUSE
NC score	0.065209 (rank : 212)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	367	Target Neighborhood Hits	579	Shared Neighborhood Hits	26
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RUFY3_HUMAN
NC score	0.064779 (rank : 213)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	367	Target Neighborhood Hits	594	Shared Neighborhood Hits	25
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

ABI3_HUMAN
NC score	0.064490 (rank : 214)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	367	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

NCOA6_MOUSE
NC score	0.064353 (rank : 215)	θ value	0.813845 (rank : 205)
Query Neighborhood Hits	367	Target Neighborhood Hits	1076	Shared Neighborhood Hits	119
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

CRKL_HUMAN
NC score	0.064301 (rank : 216)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	367	Target Neighborhood Hits	313	Shared Neighborhood Hits	29
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

MUC7_HUMAN
NC score	0.063714 (rank : 217)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	367	Target Neighborhood Hits	538	Shared Neighborhood Hits	86
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

NHLC1_MOUSE
NC score	0.063546 (rank : 218)	θ value	0.365318 (rank : 178)
Query Neighborhood Hits	367	Target Neighborhood Hits	103	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BR37	Gene names	Nhlrc1, Epm2b
Domain Architecture	No domain graphic available
Description	NHL repeat-containing protein 1 (Malin).

CRK_MOUSE
NC score	0.063500 (rank : 219)	θ value	5.27518 (rank : 291)
Query Neighborhood Hits	367	Target Neighborhood Hits	314	Shared Neighborhood Hits	32
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

ABI1_HUMAN
NC score	0.062963 (rank : 220)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	367	Target Neighborhood Hits	257	Shared Neighborhood Hits	45
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

SON_HUMAN
NC score	0.062715 (rank : 221)	θ value	0.0148317 (rank : 125)
Query Neighborhood Hits	367	Target Neighborhood Hits	1568	Shared Neighborhood Hits	149
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

AHI1_HUMAN
NC score	0.062598 (rank : 222)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	367	Target Neighborhood Hits	537	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ABI3_MOUSE
NC score	0.062579 (rank : 223)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	367	Target Neighborhood Hits	227	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

SH3G1_HUMAN
NC score	0.062392 (rank : 224)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	367	Target Neighborhood Hits	307	Shared Neighborhood Hits	33
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

CRKL_MOUSE
NC score	0.062232 (rank : 225)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	367	Target Neighborhood Hits	307	Shared Neighborhood Hits	27
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

RIMB1_HUMAN
NC score	0.062177 (rank : 226)	θ value	0.47712 (rank : 187)
Query Neighborhood Hits	367	Target Neighborhood Hits	1479	Shared Neighborhood Hits	118
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SH3G3_MOUSE
NC score	0.062070 (rank : 227)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	367	Target Neighborhood Hits	236	Shared Neighborhood Hits	27
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3G2_HUMAN
NC score	0.062042 (rank : 228)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	367	Target Neighborhood Hits	324	Shared Neighborhood Hits	36
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

PRB3_HUMAN
NC score	0.061909 (rank : 229)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	367	Target Neighborhood Hits	318	Shared Neighborhood Hits	83
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

NACAM_MOUSE
NC score	0.061891 (rank : 230)	θ value	0.21417 (rank : 158)
Query Neighborhood Hits	367	Target Neighborhood Hits	1866	Shared Neighborhood Hits	138
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

E41LB_HUMAN
NC score	0.061887 (rank : 231)	θ value	2.36792 (rank : 247)
Query Neighborhood Hits	367	Target Neighborhood Hits	79	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

SH3G3_HUMAN
NC score	0.061453 (rank : 232)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	367	Target Neighborhood Hits	222	Shared Neighborhood Hits	27
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

PRG4_HUMAN
NC score	0.061384 (rank : 233)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	367	Target Neighborhood Hits	764	Shared Neighborhood Hits	107
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

DIDO1_HUMAN
NC score	0.061250 (rank : 234)	θ value	0.0113563 (rank : 120)
Query Neighborhood Hits	367	Target Neighborhood Hits	960	Shared Neighborhood Hits	103
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

PCQAP_HUMAN
NC score	0.060931 (rank : 235)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	367	Target Neighborhood Hits	549	Shared Neighborhood Hits	78
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

CJ078_MOUSE
NC score	0.060839 (rank : 236)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	367	Target Neighborhood Hits	559	Shared Neighborhood Hits	89
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

PLCG1_MOUSE
NC score	0.060735 (rank : 237)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	367	Target Neighborhood Hits	314	Shared Neighborhood Hits	31
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

RGS3_HUMAN
NC score	0.060499 (rank : 238)	θ value	0.00298849 (rank : 113)
Query Neighborhood Hits	367	Target Neighborhood Hits	1375	Shared Neighborhood Hits	134
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

SH3G2_MOUSE
NC score	0.060369 (rank : 239)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	367	Target Neighborhood Hits	319	Shared Neighborhood Hits	36
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

GRP3_HUMAN
NC score	0.059946 (rank : 240)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	367	Target Neighborhood Hits	131	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

41_HUMAN
NC score	0.059928 (rank : 241)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	367	Target Neighborhood Hits	157	Shared Neighborhood Hits	16
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

E41LB_MOUSE
NC score	0.059607 (rank : 242)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	367	Target Neighborhood Hits	59	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

CRK_HUMAN
NC score	0.059471 (rank : 243)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	367	Target Neighborhood Hits	308	Shared Neighborhood Hits	30
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

PLCG1_HUMAN
NC score	0.059408 (rank : 244)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	367	Target Neighborhood Hits	293	Shared Neighborhood Hits	30
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

E41L5_HUMAN
NC score	0.059373 (rank : 245)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	367	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

SH3G1_MOUSE
NC score	0.059284 (rank : 246)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	367	Target Neighborhood Hits	291	Shared Neighborhood Hits	29
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

DDEF1_MOUSE
NC score	0.059261 (rank : 247)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	367	Target Neighborhood Hits	592	Shared Neighborhood Hits	77
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

41_MOUSE
NC score	0.059050 (rank : 248)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	367	Target Neighborhood Hits	184	Shared Neighborhood Hits	19
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

E41L3_HUMAN
NC score	0.059049 (rank : 249)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	367	Target Neighborhood Hits	113	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

SRRM1_HUMAN
NC score	0.058843 (rank : 250)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	367	Target Neighborhood Hits	690	Shared Neighborhood Hits	113
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

CEND1_HUMAN
NC score	0.058577 (rank : 251)	θ value	0.62314 (rank : 190)
Query Neighborhood Hits	367	Target Neighborhood Hits	284	Shared Neighborhood Hits	47
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CT032_HUMAN
NC score	0.058250 (rank : 252)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	367	Target Neighborhood Hits	235	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

WBP11_HUMAN
NC score	0.058030 (rank : 253)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	367	Target Neighborhood Hits	354	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

ASPP1_HUMAN
NC score	0.058012 (rank : 254)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	367	Target Neighborhood Hits	956	Shared Neighborhood Hits	89
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

CASL_HUMAN
NC score	0.057948 (rank : 255)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	367	Target Neighborhood Hits	259	Shared Neighborhood Hits	39
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

E41L2_MOUSE
NC score	0.057942 (rank : 256)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	367	Target Neighborhood Hits	459	Shared Neighborhood Hits	26
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

PLEK_HUMAN
NC score	0.057924 (rank : 257)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	367	Target Neighborhood Hits	110	Shared Neighborhood Hits	31
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

RHG04_HUMAN
NC score	0.057902 (rank : 258)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	367	Target Neighborhood Hits	307	Shared Neighborhood Hits	33
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

FRMD5_MOUSE
NC score	0.057523 (rank : 259)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	367	Target Neighborhood Hits	55	Shared Neighborhood Hits	5
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

E41L1_HUMAN
NC score	0.057449 (rank : 260)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	367	Target Neighborhood Hits	180	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

NPHP1_MOUSE
NC score	0.057290 (rank : 261)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	367	Target Neighborhood Hits	267	Shared Neighborhood Hits	29
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

E41L3_MOUSE
NC score	0.057216 (rank : 262)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	367	Target Neighborhood Hits	250	Shared Neighborhood Hits	12
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

FRMD5_HUMAN
NC score	0.057139 (rank : 263)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	367	Target Neighborhood Hits	55	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

ENAH_MOUSE
NC score	0.056787 (rank : 264)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	367	Target Neighborhood Hits	919	Shared Neighborhood Hits	120
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

SPTA2_HUMAN
NC score	0.056628 (rank : 265)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	367	Target Neighborhood Hits	888	Shared Neighborhood Hits	54
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

PCQAP_MOUSE
NC score	0.056525 (rank : 266)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	367	Target Neighborhood Hits	506	Shared Neighborhood Hits	75
SwissProt Accessions	Q924H2	Gene names	Pcqap
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (mPcqap).

E41L1_MOUSE
NC score	0.056477 (rank : 267)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	367	Target Neighborhood Hits	106	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

RFIP3_HUMAN
NC score	0.056431 (rank : 268)	θ value	0.0736092 (rank : 140)
Query Neighborhood Hits	367	Target Neighborhood Hits	1055	Shared Neighborhood Hits	77
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

OSTF1_HUMAN
NC score	0.056351 (rank : 269)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	367	Target Neighborhood Hits	466	Shared Neighborhood Hits	37
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

AHI1_MOUSE
NC score	0.056300 (rank : 270)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	367	Target Neighborhood Hits	496	Shared Neighborhood Hits	38
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

OSTF1_MOUSE
NC score	0.056197 (rank : 271)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	367	Target Neighborhood Hits	467	Shared Neighborhood Hits	37
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

E41L2_HUMAN
NC score	0.055938 (rank : 272)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	367	Target Neighborhood Hits	287	Shared Neighborhood Hits	15
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

CYH4_MOUSE
NC score	0.055714 (rank : 273)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	367	Target Neighborhood Hits	134	Shared Neighborhood Hits	37
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

CENB1_HUMAN
NC score	0.055706 (rank : 274)	θ value	0.0961366 (rank : 143)
Query Neighborhood Hits	367	Target Neighborhood Hits	383	Shared Neighborhood Hits	43
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

NEBL_HUMAN
NC score	0.055447 (rank : 275)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	367	Target Neighborhood Hits	457	Shared Neighborhood Hits	37
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

GSCR1_HUMAN
NC score	0.055381 (rank : 276)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	367	Target Neighborhood Hits	674	Shared Neighborhood Hits	117
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

BI2L1_MOUSE
NC score	0.055349 (rank : 277)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	367	Target Neighborhood Hits	197	Shared Neighborhood Hits	37
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

E41LA_HUMAN
NC score	0.054663 (rank : 278)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	367	Target Neighborhood Hits	87	Shared Neighborhood Hits	10
SwissProt Accessions	Q9HCS5	Gene names	EPB41L4A, EPB41L4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

RFFL_MOUSE
NC score	0.054547 (rank : 279)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	367	Target Neighborhood Hits	145	Shared Neighborhood Hits	38
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

CASL_MOUSE
NC score	0.054105 (rank : 280)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	367	Target Neighborhood Hits	225	Shared Neighborhood Hits	35
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

WBP11_MOUSE
NC score	0.053722 (rank : 281)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	367	Target Neighborhood Hits	362	Shared Neighborhood Hits	83
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

MBD6_HUMAN
NC score	0.053647 (rank : 282)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	367	Target Neighborhood Hits	349	Shared Neighborhood Hits	68
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

TARA_MOUSE
NC score	0.053593 (rank : 283)	θ value	2.36792 (rank : 255)
Query Neighborhood Hits	367	Target Neighborhood Hits	1133	Shared Neighborhood Hits	104
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

E41LA_MOUSE
NC score	0.053461 (rank : 284)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	367	Target Neighborhood Hits	85	Shared Neighborhood Hits	11
SwissProt Accessions	P52963	Gene names	Epb41l4a, Epb4.1l4, Epb4.1l4a, Epb41l4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

NHLC1_HUMAN
NC score	0.053264 (rank : 285)	θ value	0.62314 (rank : 195)
Query Neighborhood Hits	367	Target Neighborhood Hits	91	Shared Neighborhood Hits	10
SwissProt Accessions	Q6VVB1, Q6IMH1	Gene names	NHLRC1, EPM2B
Domain Architecture	No domain graphic available
Description	NHL repeat-containing protein 1 (Malin).

DBNL_HUMAN
NC score	0.053219 (rank : 286)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	367	Target Neighborhood Hits	244	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

SYTL4_HUMAN
NC score	0.053090 (rank : 287)	θ value	0.163984 (rank : 150)
Query Neighborhood Hits	367	Target Neighborhood Hits	138	Shared Neighborhood Hits	27
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

CEND1_MOUSE
NC score	0.052821 (rank : 288)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	367	Target Neighborhood Hits	260	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

SPR1B_MOUSE
NC score	0.052816 (rank : 289)	θ value	0.0113563 (rank : 121)
Query Neighborhood Hits	367	Target Neighborhood Hits	395	Shared Neighborhood Hits	50
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

BCL9_HUMAN
NC score	0.052700 (rank : 290)	θ value	2.36792 (rank : 244)
Query Neighborhood Hits	367	Target Neighborhood Hits	1008	Shared Neighborhood Hits	117
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

MNT_HUMAN
NC score	0.052553 (rank : 291)	θ value	4.03905 (rank : 283)
Query Neighborhood Hits	367	Target Neighborhood Hits	496	Shared Neighborhood Hits	82
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

RHG26_HUMAN
NC score	0.052501 (rank : 292)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	367	Target Neighborhood Hits	281	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

LCP2_HUMAN
NC score	0.052492 (rank : 293)	θ value	0.0736092 (rank : 139)
Query Neighborhood Hits	367	Target Neighborhood Hits	531	Shared Neighborhood Hits	78
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

PEX13_MOUSE
NC score	0.052247 (rank : 294)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	367	Target Neighborhood Hits	126	Shared Neighborhood Hits	22
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

DBNL_MOUSE
NC score	0.052232 (rank : 295)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	367	Target Neighborhood Hits	306	Shared Neighborhood Hits	34
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

SPTA1_MOUSE
NC score	0.052055 (rank : 296)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	367	Target Neighborhood Hits	675	Shared Neighborhood Hits	44
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

MDC1_MOUSE
NC score	0.051965 (rank : 297)	θ value	0.00869519 (rank : 119)
Query Neighborhood Hits	367	Target Neighborhood Hits	998	Shared Neighborhood Hits	90
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

CYH1_HUMAN
NC score	0.051834 (rank : 298)	θ value	8.99809 (rank : 344)
Query Neighborhood Hits	367	Target Neighborhood Hits	184	Shared Neighborhood Hits	40
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

TARA_HUMAN
NC score	0.051719 (rank : 299)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	367	Target Neighborhood Hits	1626	Shared Neighborhood Hits	127
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

SPTA1_HUMAN
NC score	0.051675 (rank : 300)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	367	Target Neighborhood Hits	748	Shared Neighborhood Hits	49
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

PLEK_MOUSE
NC score	0.051667 (rank : 301)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	367	Target Neighborhood Hits	109	Shared Neighborhood Hits	24
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

PEX13_HUMAN
NC score	0.051451 (rank : 302)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	367	Target Neighborhood Hits	128	Shared Neighborhood Hits	28
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

WIRE_HUMAN
NC score	0.051375 (rank : 303)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	367	Target Neighborhood Hits	329	Shared Neighborhood Hits	81
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

LASP1_HUMAN
NC score	0.051292 (rank : 304)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	367	Target Neighborhood Hits	293	Shared Neighborhood Hits	32
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

RNF34_MOUSE
NC score	0.051159 (rank : 305)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	367	Target Neighborhood Hits	160	Shared Neighborhood Hits	35
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

BAT2_MOUSE
NC score	0.051015 (rank : 306)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	367	Target Neighborhood Hits	947	Shared Neighborhood Hits	128
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

WIRE_MOUSE
NC score	0.050403 (rank : 307)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	367	Target Neighborhood Hits	310	Shared Neighborhood Hits	79
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

OGFR_MOUSE
NC score	0.050339 (rank : 308)	θ value	1.38821 (rank : 227)
Query Neighborhood Hits	367	Target Neighborhood Hits	584	Shared Neighborhood Hits	68
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

BAG3_MOUSE
NC score	0.050199 (rank : 309)	θ value	0.0736092 (rank : 138)
Query Neighborhood Hits	367	Target Neighborhood Hits	513	Shared Neighborhood Hits	81
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

RPGF1_HUMAN
NC score	0.050138 (rank : 310)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	367	Target Neighborhood Hits	262	Shared Neighborhood Hits	27
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

CYH1_MOUSE
NC score	0.050118 (rank : 311)	θ value	3.0926 (rank : 262)
Query Neighborhood Hits	367	Target Neighborhood Hits	176	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

PKHA1_HUMAN
NC score	0.050116 (rank : 312)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	367	Target Neighborhood Hits	127	Shared Neighborhood Hits	36
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

FNBP2_HUMAN
NC score	0.050109 (rank : 313)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	367	Target Neighborhood Hits	432	Shared Neighborhood Hits	46
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

CYH4_HUMAN
NC score	0.050007 (rank : 314)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	367	Target Neighborhood Hits	135	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

K1802_MOUSE
NC score	0.049460 (rank : 315)	θ value	0.00228821 (rank : 110)
Query Neighborhood Hits	367	Target Neighborhood Hits	1596	Shared Neighborhood Hits	122
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MLL3_HUMAN
NC score	0.048725 (rank : 316)	θ value	0.0431538 (rank : 133)
Query Neighborhood Hits	367	Target Neighborhood Hits	1644	Shared Neighborhood Hits	132
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

FA47B_HUMAN
NC score	0.048673 (rank : 317)	θ value	0.62314 (rank : 192)
Query Neighborhood Hits	367	Target Neighborhood Hits	431	Shared Neighborhood Hits	65
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

CIC_HUMAN
NC score	0.048303 (rank : 318)	θ value	3.0926 (rank : 258)
Query Neighborhood Hits	367	Target Neighborhood Hits	992	Shared Neighborhood Hits	125
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

CO4A5_HUMAN
NC score	0.047833 (rank : 319)	θ value	0.365318 (rank : 174)
Query Neighborhood Hits	367	Target Neighborhood Hits	383	Shared Neighborhood Hits	70
SwissProt Accessions	P29400, Q16006, Q16126, Q6LD84	Gene names	COL4A5
Domain Architecture
Description	Collagen alpha-5(IV) chain precursor.

MTSS1_MOUSE
NC score	0.047680 (rank : 320)	θ value	6.88961 (rank : 324)
Query Neighborhood Hits	367	Target Neighborhood Hits	592	Shared Neighborhood Hits	87
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

CO5A1_MOUSE
NC score	0.047519 (rank : 321)	θ value	0.47712 (rank : 182)
Query Neighborhood Hits	367	Target Neighborhood Hits	419	Shared Neighborhood Hits	82
SwissProt Accessions	O88207	Gene names	Col5a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(V) chain precursor.

PI5PA_HUMAN
NC score	0.047460 (rank : 322)	θ value	0.279714 (rank : 168)
Query Neighborhood Hits	367	Target Neighborhood Hits	749	Shared Neighborhood Hits	95
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

CO3A1_HUMAN
NC score	0.047321 (rank : 323)	θ value	3.0926 (rank : 260)
Query Neighborhood Hits	367	Target Neighborhood Hits	452	Shared Neighborhood Hits	76
SwissProt Accessions	P02461, Q15112, Q16403, Q6LDB3, Q6LDJ2, Q6LDJ3, Q7KZ56	Gene names	COL3A1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

SRRM2_MOUSE
NC score	0.047151 (rank : 324)	θ value	8.99809 (rank : 361)
Query Neighborhood Hits	367	Target Neighborhood Hits	1470	Shared Neighborhood Hits	121
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

WASF1_MOUSE
NC score	0.046884 (rank : 325)	θ value	0.279714 (rank : 171)
Query Neighborhood Hits	367	Target Neighborhood Hits	261	Shared Neighborhood Hits	75
SwissProt Accessions	Q8R5H6, Q91W51, Q9ERQ9	Gene names	Wasf1, Wave1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1).

CENA1_HUMAN
NC score	0.046753 (rank : 326)	θ value	4.03905 (rank : 274)
Query Neighborhood Hits	367	Target Neighborhood Hits	87	Shared Neighborhood Hits	30
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

MDC1_HUMAN
NC score	0.046737 (rank : 327)	θ value	6.88961 (rank : 323)
Query Neighborhood Hits	367	Target Neighborhood Hits	1446	Shared Neighborhood Hits	104
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MINT_MOUSE
NC score	0.046633 (rank : 328)	θ value	0.0563607 (rank : 135)
Query Neighborhood Hits	367	Target Neighborhood Hits	1514	Shared Neighborhood Hits	114
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

ZIMP7_MOUSE
NC score	0.046601 (rank : 329)	θ value	0.21417 (rank : 160)
Query Neighborhood Hits	367	Target Neighborhood Hits	566	Shared Neighborhood Hits	75
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

MILK1_HUMAN
NC score	0.046571 (rank : 330)	θ value	0.279714 (rank : 165)
Query Neighborhood Hits	367	Target Neighborhood Hits	427	Shared Neighborhood Hits	79
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

CO5A1_HUMAN
NC score	0.045749 (rank : 331)	θ value	0.813845 (rank : 200)
Query Neighborhood Hits	367	Target Neighborhood Hits	434	Shared Neighborhood Hits	76
SwissProt Accessions	P20908, Q15094, Q5SUX4	Gene names	COL5A1
Domain Architecture
Description	Collagen alpha-1(V) chain precursor.

CO3A1_MOUSE
NC score	0.045558 (rank : 332)	θ value	1.38821 (rank : 220)
Query Neighborhood Hits	367	Target Neighborhood Hits	466	Shared Neighborhood Hits	73
SwissProt Accessions	P08121, Q61429, Q9CRN7	Gene names	Col3a1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

CO6A2_MOUSE
NC score	0.044959 (rank : 333)	θ value	0.0193708 (rank : 126)
Query Neighborhood Hits	367	Target Neighborhood Hits	260	Shared Neighborhood Hits	48
SwissProt Accessions	Q02788, Q05505	Gene names	Col6a2
Domain Architecture
Description	Collagen alpha-2(VI) chain precursor.

CO6A2_HUMAN
NC score	0.044336 (rank : 334)	θ value	0.0961366 (rank : 145)
Query Neighborhood Hits	367	Target Neighborhood Hits	249	Shared Neighborhood Hits	50
SwissProt Accessions	P12110, Q13909, Q13910, Q13911, Q14049, Q16259, Q16597, Q9UML3	Gene names	COL6A2
Domain Architecture
Description	Collagen alpha-2(VI) chain precursor.

SOX13_MOUSE
NC score	0.044176 (rank : 335)	θ value	0.00102713 (rank : 106)
Query Neighborhood Hits	367	Target Neighborhood Hits	495	Shared Neighborhood Hits	52
SwissProt Accessions	Q04891, Q922L3	Gene names	Sox13, Sox-13
Domain Architecture
Description	SOX-13 protein.

COHA1_HUMAN
NC score	0.044154 (rank : 336)	θ value	0.279714 (rank : 162)
Query Neighborhood Hits	367	Target Neighborhood Hits	400	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UMD9, Q02802, Q99018, Q9NQK9, Q9UC14	Gene names	COL17A1, BP180, BPAG2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

WASF1_HUMAN
NC score	0.044143 (rank : 337)	θ value	0.62314 (rank : 196)
Query Neighborhood Hits	367	Target Neighborhood Hits	260	Shared Neighborhood Hits	71
SwissProt Accessions	Q92558	Gene names	WASF1, KIAA0269, SCAR1, WAVE1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1).

CNTRB_MOUSE
NC score	0.043007 (rank : 338)	θ value	0.0961366 (rank : 144)
Query Neighborhood Hits	367	Target Neighborhood Hits	1029	Shared Neighborhood Hits	53
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

MILK1_MOUSE
NC score	0.042263 (rank : 339)	θ value	3.0926 (rank : 267)
Query Neighborhood Hits	367	Target Neighborhood Hits	788	Shared Neighborhood Hits	102
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

CRSP7_HUMAN
NC score	0.042058 (rank : 340)	θ value	0.813845 (rank : 201)
Query Neighborhood Hits	367	Target Neighborhood Hits	247	Shared Neighborhood Hits	42
SwissProt Accessions	O95402	Gene names	CRSP7, ARC70
Domain Architecture
Description	CRSP complex subunit 7 (Cofactor required for Sp1 transcriptional activation subunit 7) (Transcriptional coactivator CRSP70) (Activator- recruited cofactor 70 kDa component) (ARC70).

SYTL3_MOUSE
NC score	0.041222 (rank : 341)	θ value	0.163984 (rank : 149)
Query Neighborhood Hits	367	Target Neighborhood Hits	110	Shared Neighborhood Hits	19
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

SPTN4_HUMAN
NC score	0.041025 (rank : 342)	θ value	0.279714 (rank : 170)
Query Neighborhood Hits	367	Target Neighborhood Hits	570	Shared Neighborhood Hits	62
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

DP13B_HUMAN
NC score	0.040615 (rank : 343)	θ value	3.0926 (rank : 263)
Query Neighborhood Hits	367	Target Neighborhood Hits	58	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

SPR1A_MOUSE
NC score	0.040327 (rank : 344)	θ value	0.813845 (rank : 208)
Query Neighborhood Hits	367	Target Neighborhood Hits	343	Shared Neighborhood Hits	43
SwissProt Accessions	Q62266	Gene names	Sprr1a
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein 1A) (SPR1A) (SPR1 A).

SYTL4_MOUSE
NC score	0.040217 (rank : 345)	θ value	1.06291 (rank : 217)
Query Neighborhood Hits	367	Target Neighborhood Hits	137	Shared Neighborhood Hits	24
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

CO2A1_HUMAN
NC score	0.039828 (rank : 346)	θ value	6.88961 (rank : 313)
Query Neighborhood Hits	367	Target Neighborhood Hits	486	Shared Neighborhood Hits	67
SwissProt Accessions	P02458, Q12985, Q14009, Q14044, Q14046, Q14056, Q14058, Q16672, Q6LBY1, Q6LBY2, Q6LBY3, Q99227, Q9UE38, Q9UE39, Q9UE40, Q9UE41, Q9UE42, Q9UE43	Gene names	COL2A1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

TXND2_HUMAN
NC score	0.039728 (rank : 347)	θ value	0.0563607 (rank : 137)
Query Neighborhood Hits	367	Target Neighborhood Hits	793	Shared Neighborhood Hits	67
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

ARRD2_HUMAN
NC score	0.038723 (rank : 348)	θ value	0.0148317 (rank : 122)
Query Neighborhood Hits	367	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TBH0, O95895, Q6ZRV9, Q8WYG6	Gene names	ARRDC2
Domain Architecture	No domain graphic available
Description	Arrestin domain-containing protein 2.

CO4A3_HUMAN
NC score	0.037182 (rank : 349)	θ value	8.99809 (rank : 340)
Query Neighborhood Hits	367	Target Neighborhood Hits	421	Shared Neighborhood Hits	65
SwissProt Accessions	Q01955, Q9BQT2	Gene names	COL4A3
Domain Architecture
Description	Collagen alpha-3(IV) chain precursor (Goodpasture antigen).

CO039_MOUSE
NC score	0.037068 (rank : 350)	θ value	1.81305 (rank : 232)
Query Neighborhood Hits	367	Target Neighborhood Hits	445	Shared Neighborhood Hits	70
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

EMID2_HUMAN
NC score	0.037058 (rank : 351)	θ value	0.813845 (rank : 202)
Query Neighborhood Hits	367	Target Neighborhood Hits	226	Shared Neighborhood Hits	59
SwissProt Accessions	Q96A83	Gene names	EMID2, COL26A1, EMU2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXVI) chain precursor (EMI domain-containing protein 2) (Protein Emu2) (Emilin and multimerin domain-containing protein 2).

SSBP4_HUMAN
NC score	0.036855 (rank : 352)	θ value	1.81305 (rank : 240)
Query Neighborhood Hits	367	Target Neighborhood Hits	753	Shared Neighborhood Hits	85
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

ZN385_HUMAN
NC score	0.036757 (rank : 353)	θ value	2.36792 (rank : 256)
Query Neighborhood Hits	367	Target Neighborhood Hits	614	Shared Neighborhood Hits	73
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

APXL_HUMAN
NC score	0.036738 (rank : 354)	θ value	0.813845 (rank : 197)
Query Neighborhood Hits	367	Target Neighborhood Hits	553	Shared Neighborhood Hits	64
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

CO4A2_HUMAN
NC score	0.036676 (rank : 355)	θ value	0.813845 (rank : 199)
Query Neighborhood Hits	367	Target Neighborhood Hits	454	Shared Neighborhood Hits	67
SwissProt Accessions	P08572	Gene names	COL4A2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

SETBP_HUMAN
NC score	0.036587 (rank : 356)	θ value	0.47712 (rank : 188)
Query Neighborhood Hits	367	Target Neighborhood Hits	305	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y6X0, Q9UEF3	Gene names	SETBP1, KIAA0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

COBA2_HUMAN
NC score	0.036484 (rank : 357)	θ value	6.88961 (rank : 314)
Query Neighborhood Hits	367	Target Neighborhood Hits	408	Shared Neighborhood Hits	68
SwissProt Accessions	P13942, Q07751, Q13271, Q13272, Q13273, Q99866, Q9UIP9	Gene names	COL11A2
Domain Architecture
Description	Collagen alpha-2(XI) chain precursor.

CO4A1_MOUSE
NC score	0.036189 (rank : 358)	θ value	3.0926 (rank : 261)
Query Neighborhood Hits	367	Target Neighborhood Hits	450	Shared Neighborhood Hits	66
SwissProt Accessions	P02463	Gene names	Col4a1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

SYNJ1_MOUSE
NC score	0.036156 (rank : 359)	θ value	8.99809 (rank : 363)
Query Neighborhood Hits	367	Target Neighborhood Hits	516	Shared Neighborhood Hits	96
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

CO1A2_HUMAN
NC score	0.036128 (rank : 360)	θ value	4.03905 (rank : 275)
Query Neighborhood Hits	367	Target Neighborhood Hits	329	Shared Neighborhood Hits	62
SwissProt Accessions	P08123, P02464, Q9UEB6, Q9UPH0	Gene names	COL1A2
Domain Architecture
Description	Collagen alpha-2(I) chain precursor.

CIC_MOUSE
NC score	0.035978 (rank : 361)	θ value	6.88961 (rank : 312)
Query Neighborhood Hits	367	Target Neighborhood Hits	742	Shared Neighborhood Hits	105
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

CBP_HUMAN
NC score	0.035952 (rank : 362)	θ value	8.99809 (rank : 337)
Query Neighborhood Hits	367	Target Neighborhood Hits	941	Shared Neighborhood Hits	107
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CCD45_MOUSE
NC score	0.035594 (rank : 363)	θ value	0.813845 (rank : 198)
Query Neighborhood Hits	367	Target Neighborhood Hits	663	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BVV7	Gene names	Ccdc45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

CS007_MOUSE
NC score	0.035468 (rank : 364)	θ value	1.38821 (rank : 221)
Query Neighborhood Hits	367	Target Neighborhood Hits	464	Shared Neighborhood Hits	77
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

DP13B_MOUSE
NC score	0.034534 (rank : 365)	θ value	8.99809 (rank : 346)
Query Neighborhood Hits	367	Target Neighborhood Hits	58	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

CO4A1_HUMAN
NC score	0.033891 (rank : 366)	θ value	4.03905 (rank : 276)
Query Neighborhood Hits	367	Target Neighborhood Hits	425	Shared Neighborhood Hits	69
SwissProt Accessions	P02462	Gene names	COL4A1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

CENG1_MOUSE
NC score	0.033517 (rank : 367)	θ value	0.365318 (rank : 173)
Query Neighborhood Hits	367	Target Neighborhood Hits	531	Shared Neighborhood Hits	46
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

JPH2_HUMAN
NC score	0.033277 (rank : 368)	θ value	4.03905 (rank : 281)
Query Neighborhood Hits	367	Target Neighborhood Hits	639	Shared Neighborhood Hits	87
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

ZIM10_HUMAN
NC score	0.032966 (rank : 369)	θ value	1.81305 (rank : 243)
Query Neighborhood Hits	367	Target Neighborhood Hits	577	Shared Neighborhood Hits	84
SwissProt Accessions	Q9ULJ6, Q7Z7E6	Gene names	RAI17, KIAA1224, ZIMP10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

COIA1_HUMAN
NC score	0.032704 (rank : 370)	θ value	8.99809 (rank : 341)
Query Neighborhood Hits	367	Target Neighborhood Hits	447	Shared Neighborhood Hits	76
SwissProt Accessions	P39060, Q9UK38, Q9Y6Q7, Q9Y6Q8	Gene names	COL18A1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

CONA1_MOUSE
NC score	0.032638 (rank : 371)	θ value	6.88961 (rank : 315)
Query Neighborhood Hits	367	Target Neighborhood Hits	254	Shared Neighborhood Hits	50
SwissProt Accessions	Q8K4G2, Q5SUQ0	Gene names	Col23a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXIII) chain.

CO7A1_HUMAN
NC score	0.032187 (rank : 372)	θ value	0.0330416 (rank : 131)
Query Neighborhood Hits	367	Target Neighborhood Hits	807	Shared Neighborhood Hits	81
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

CENPF_HUMAN
NC score	0.032146 (rank : 373)	θ value	5.27518 (rank : 290)
Query Neighborhood Hits	367	Target Neighborhood Hits	1932	Shared Neighborhood Hits	69
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

BLNK_MOUSE
NC score	0.032037 (rank : 374)	θ value	6.88961 (rank : 310)
Query Neighborhood Hits	367	Target Neighborhood Hits	296	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

SOX13_HUMAN
NC score	0.031598 (rank : 375)	θ value	0.813845 (rank : 207)
Query Neighborhood Hits	367	Target Neighborhood Hits	464	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UN79, O95275, O95826, Q9UHW7	Gene names	SOX13
Domain Architecture
Description	SOX-13 protein (Type 1 diabetes autoantigen ICA12) (Islet cell antigen 12).

PHC1_MOUSE
NC score	0.031462 (rank : 376)	θ value	1.06291 (rank : 216)
Query Neighborhood Hits	367	Target Neighborhood Hits	205	Shared Neighborhood Hits	31
SwissProt Accessions	Q64028, P70359, Q64307, Q8BZ80	Gene names	Phc1, Edr, Edr1, Rae28
Domain Architecture
Description	Polyhomeotic-like protein 1 (mPH1) (Early development regulatory protein 1) (RAE-28).

CENG1_HUMAN
NC score	0.031381 (rank : 377)	θ value	0.62314 (rank : 191)
Query Neighborhood Hits	367	Target Neighborhood Hits	544	Shared Neighborhood Hits	45
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

PCID2_MOUSE
NC score	0.030800 (rank : 378)	θ value	1.38821 (rank : 228)
Query Neighborhood Hits	367	Target Neighborhood Hits	5	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BFV2, Q8C951	Gene names	Pcid2
Domain Architecture	No domain graphic available
Description	PCI domain-containing protein 2 (CSN12-like protein).

GA2L2_MOUSE
NC score	0.030006 (rank : 379)	θ value	0.62314 (rank : 193)
Query Neighborhood Hits	367	Target Neighborhood Hits	395	Shared Neighborhood Hits	52
SwissProt Accessions	Q5SSG4	Gene names	Gas2l2
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2).

SETBP_MOUSE
NC score	0.029895 (rank : 380)	θ value	5.27518 (rank : 303)
Query Neighborhood Hits	367	Target Neighborhood Hits	352	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Z180, Q66JL8	Gene names	Setbp1, Kiaa0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

CSKI1_MOUSE
NC score	0.029623 (rank : 381)	θ value	8.99809 (rank : 342)
Query Neighborhood Hits	367	Target Neighborhood Hits	1031	Shared Neighborhood Hits	123
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

ZN185_HUMAN
NC score	0.029578 (rank : 382)	θ value	0.163984 (rank : 152)
Query Neighborhood Hits	367	Target Neighborhood Hits	112	Shared Neighborhood Hits	13
SwissProt Accessions	O15231, O00345, Q9NSD2	Gene names	ZNF185
Domain Architecture
Description	Zinc finger protein 185 (LIM-domain protein ZNF185) (P1-A).

FLNC_HUMAN
NC score	0.028891 (rank : 383)	θ value	0.813845 (rank : 204)
Query Neighborhood Hits	367	Target Neighborhood Hits	116	Shared Neighborhood Hits	16
SwissProt Accessions	Q14315, O95303, Q07985, Q9NS12, Q9NYE5, Q9UMR8, Q9Y503	Gene names	FLNC, ABPL, FLN2
Domain Architecture
Description	Filamin-C (Gamma-filamin) (Filamin-2) (Protein FLNc) (Actin-binding- like protein) (ABP-L) (ABP-280-like protein).

SEPT9_HUMAN
NC score	0.028414 (rank : 384)	θ value	0.00298849 (rank : 114)
Query Neighborhood Hits	367	Target Neighborhood Hits	706	Shared Neighborhood Hits	64
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

MTSS1_HUMAN
NC score	0.027678 (rank : 385)	θ value	8.99809 (rank : 355)
Query Neighborhood Hits	367	Target Neighborhood Hits	504	Shared Neighborhood Hits	66
SwissProt Accessions	O43312, Q8TCA2, Q96RX2	Gene names	MTSS1, KIAA0429, MIM
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein) (Metastasis suppressor YGL-1).

CENPE_HUMAN
NC score	0.027330 (rank : 386)	θ value	8.99809 (rank : 338)
Query Neighborhood Hits	367	Target Neighborhood Hits	2060	Shared Neighborhood Hits	78
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

IWS1_MOUSE
NC score	0.027310 (rank : 387)	θ value	2.36792 (rank : 251)
Query Neighborhood Hits	367	Target Neighborhood Hits	1258	Shared Neighborhood Hits	74
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

DLG5_HUMAN
NC score	0.027160 (rank : 388)	θ value	2.36792 (rank : 246)
Query Neighborhood Hits	367	Target Neighborhood Hits	1088	Shared Neighborhood Hits	67
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

TACC3_HUMAN
NC score	0.026803 (rank : 389)	θ value	1.81305 (rank : 241)
Query Neighborhood Hits	367	Target Neighborhood Hits	779	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

FLNA_HUMAN
NC score	0.026583 (rank : 390)	θ value	0.21417 (rank : 157)
Query Neighborhood Hits	367	Target Neighborhood Hits	138	Shared Neighborhood Hits	12
SwissProt Accessions	P21333	Gene names	FLNA, FLN, FLN1
Domain Architecture
Description	Filamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin).

GLYG2_HUMAN
NC score	0.026520 (rank : 391)	θ value	1.81305 (rank : 234)
Query Neighborhood Hits	367	Target Neighborhood Hits	65	Shared Neighborhood Hits	9
SwissProt Accessions	O15488, O15485, O15486, O15487, O15489, O15490	Gene names	GYG2
Domain Architecture
Description	Glycogenin-2 (EC 2.4.1.186) (GN-2) (GN2).

FLNA_MOUSE
NC score	0.026396 (rank : 392)	θ value	0.279714 (rank : 164)
Query Neighborhood Hits	367	Target Neighborhood Hits	142	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BTM8, O54934, Q7TQI1, Q8BLK1, Q8BTN7, Q8VHX5, Q8VHX8, Q99KQ2	Gene names	Flna, Fln, Fln1
Domain Architecture
Description	Filamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin).

NSD1_MOUSE
NC score	0.026152 (rank : 393)	θ value	1.38821 (rank : 226)
Query Neighborhood Hits	367	Target Neighborhood Hits	472	Shared Neighborhood Hits	45
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

FLNB_MOUSE
NC score	0.026012 (rank : 394)	θ value	3.0926 (rank : 265)
Query Neighborhood Hits	367	Target Neighborhood Hits	126	Shared Neighborhood Hits	15
SwissProt Accessions	Q80X90, Q8VHX4, Q8VHX7, Q99KY3	Gene names	Flnb
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (ABP- 280-like protein).

IWS1_HUMAN
NC score	0.025607 (rank : 395)	θ value	6.88961 (rank : 321)
Query Neighborhood Hits	367	Target Neighborhood Hits	1241	Shared Neighborhood Hits	72
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

TM108_MOUSE
NC score	0.025601 (rank : 396)	θ value	4.03905 (rank : 284)
Query Neighborhood Hits	367	Target Neighborhood Hits	336	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BHE4, Q80WR9	Gene names	Tmem108
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

FLNB_HUMAN
NC score	0.025583 (rank : 397)	θ value	3.0926 (rank : 264)
Query Neighborhood Hits	367	Target Neighborhood Hits	111	Shared Neighborhood Hits	13
SwissProt Accessions	O75369, Q13706, Q8WXS9, Q8WXT0, Q8WXT1, Q8WXT2, Q9NRB5, Q9NT26, Q9UEV9	Gene names	FLNB, FLN1L, FLN3, TABP, TAP
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) (ABP- 280 homolog) (ABP-278) (Filamin 3) (Filamin homolog 1) (Fh1).

PCID2_HUMAN
NC score	0.025376 (rank : 398)	θ value	3.0926 (rank : 268)
Query Neighborhood Hits	367	Target Neighborhood Hits	6	Shared Neighborhood Hits	4
SwissProt Accessions	Q5JVF3, Q3ZCX1, Q5TC57, Q5TC58, Q9H7K1, Q9HBZ7, Q9NUK6, Q9NVY1, Q9NW44, Q9NWH3	Gene names	PCID2
Domain Architecture	No domain graphic available
Description	PCI domain-containing protein 2 (CSN12-like protein).

PDZD2_HUMAN
NC score	0.024184 (rank : 399)	θ value	1.81305 (rank : 238)
Query Neighborhood Hits	367	Target Neighborhood Hits	772	Shared Neighborhood Hits	64
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

CENG2_MOUSE
NC score	0.023606 (rank : 400)	θ value	5.27518 (rank : 289)
Query Neighborhood Hits	367	Target Neighborhood Hits	463	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

CD2_HUMAN
NC score	0.023578 (rank : 401)	θ value	5.27518 (rank : 288)
Query Neighborhood Hits	367	Target Neighborhood Hits	504	Shared Neighborhood Hits	55
SwissProt Accessions	P06729, Q96TE5	Gene names	CD2
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Erythrocyte receptor) (Rosette receptor).

CENG2_HUMAN
NC score	0.023534 (rank : 402)	θ value	6.88961 (rank : 311)
Query Neighborhood Hits	367	Target Neighborhood Hits	471	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

PSL1_HUMAN
NC score	0.023494 (rank : 403)	θ value	3.0926 (rank : 269)
Query Neighborhood Hits	367	Target Neighborhood Hits	650	Shared Neighborhood Hits	71
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

AHTF1_HUMAN
NC score	0.022917 (rank : 404)	θ value	1.81305 (rank : 230)
Query Neighborhood Hits	367	Target Neighborhood Hits	286	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WYP5, Q7Z4E3, Q8IZA4, Q96EH9, Q9Y4Q6	Gene names	AHCTF1, ELYS, TMBS62
Domain Architecture	No domain graphic available
Description	AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac).

GAB1_MOUSE
NC score	0.022195 (rank : 405)	θ value	1.38821 (rank : 222)
Query Neighborhood Hits	367	Target Neighborhood Hits	233	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

EGLN1_MOUSE
NC score	0.021520 (rank : 406)	θ value	2.36792 (rank : 248)
Query Neighborhood Hits	367	Target Neighborhood Hits	88	Shared Neighborhood Hits	16
SwissProt Accessions	Q91YE3, Q8VHJ2, Q922P3	Gene names	Egln1
Domain Architecture
Description	Egl nine homolog 1 (EC 1.14.11.-) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-prolyl hydroxylase 2) (HIF-PH2) (HPH-2) (SM-20).

GLDN_HUMAN
NC score	0.021515 (rank : 407)	θ value	2.36792 (rank : 250)
Query Neighborhood Hits	367	Target Neighborhood Hits	159	Shared Neighborhood Hits	30
SwissProt Accessions	Q6ZMI3, Q6UXZ7, Q7Z359	Gene names	GLDN, COLM
Domain Architecture	No domain graphic available
Description	Gliomedin.

NCOA3_MOUSE
NC score	0.021006 (rank : 408)	θ value	0.21417 (rank : 159)
Query Neighborhood Hits	367	Target Neighborhood Hits	203	Shared Neighborhood Hits	34
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

MYT1L_MOUSE
NC score	0.020863 (rank : 409)	θ value	0.47712 (rank : 185)
Query Neighborhood Hits	367	Target Neighborhood Hits	461	Shared Neighborhood Hits	24
SwissProt Accessions	P97500, O08996, Q8C643, Q8C7L4, Q8CHB4	Gene names	Myt1l, Kiaa1106, Nzf1, Png1
Domain Architecture	No domain graphic available
Description	Myelin transcription factor 1-like protein (MyT1L protein) (Postmitotic neural gene 1 protein) (Zinc finger protein Png-1) (Neural zinc finger factor 1) (NZF-1).

STAT2_MOUSE
NC score	0.020331 (rank : 410)	θ value	0.0961366 (rank : 146)
Query Neighborhood Hits	367	Target Neighborhood Hits	175	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WVL2, Q64188, Q64189, Q64250	Gene names	Stat2
Domain Architecture
Description	Signal transducer and activator of transcription 2.

CUTL2_HUMAN
NC score	0.019775 (rank : 411)	θ value	4.03905 (rank : 277)
Query Neighborhood Hits	367	Target Neighborhood Hits	906	Shared Neighborhood Hits	70
SwissProt Accessions	O14529	Gene names	CUTL2, KIAA0293
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

NFM_HUMAN
NC score	0.019399 (rank : 412)	θ value	5.27518 (rank : 297)
Query Neighborhood Hits	367	Target Neighborhood Hits	1328	Shared Neighborhood Hits	84
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

GAK5_HUMAN
NC score	0.018872 (rank : 413)	θ value	8.99809 (rank : 348)
Query Neighborhood Hits	367	Target Neighborhood Hits	429	Shared Neighborhood Hits	48
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK6_HUMAN
NC score	0.018533 (rank : 414)	θ value	1.38821 (rank : 223)
Query Neighborhood Hits	367	Target Neighborhood Hits	392	Shared Neighborhood Hits	46
SwissProt Accessions	P62685	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_8p23.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K115 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK12_HUMAN
NC score	0.018256 (rank : 415)	θ value	5.27518 (rank : 294)
Query Neighborhood Hits	367	Target Neighborhood Hits	374	Shared Neighborhood Hits	44
SwissProt Accessions	P63130, Q9UKI0	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q22 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K102 Gag protein) (HERV-K(III) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

MYO15_HUMAN
NC score	0.018243 (rank : 416)	θ value	0.279714 (rank : 166)
Query Neighborhood Hits	367	Target Neighborhood Hits	671	Shared Neighborhood Hits	97
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

GAK7_HUMAN
NC score	0.018203 (rank : 417)	θ value	1.06291 (rank : 213)
Query Neighborhood Hits	367	Target Neighborhood Hits	90	Shared Neighborhood Hits	21
SwissProt Accessions	Q96PI4, Q9QC08	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q23.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K18 Gag protein) (HERV-K110 Gag protein) (HERV-K(C1a) Gag protein) [Contains: Matrix protein].

GAK4_HUMAN
NC score	0.017792 (rank : 418)	θ value	6.88961 (rank : 319)
Query Neighborhood Hits	367	Target Neighborhood Hits	415	Shared Neighborhood Hits	46
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

ALMS1_MOUSE
NC score	0.017735 (rank : 419)	θ value	4.03905 (rank : 271)
Query Neighborhood Hits	367	Target Neighborhood Hits	181	Shared Neighborhood Hits	22
SwissProt Accessions	Q8K4E0, Q6A084, Q8C9N9	Gene names	Alms1, Kiaa0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1 homolog.

GAK11_HUMAN
NC score	0.017600 (rank : 420)	θ value	6.88961 (rank : 316)
Query Neighborhood Hits	367	Target Neighborhood Hits	409	Shared Neighborhood Hits	45
SwissProt Accessions	P63145, Q9UKI1	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_22q11.21 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K101 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

TS13_MOUSE
NC score	0.017371 (rank : 421)	θ value	6.88961 (rank : 332)
Query Neighborhood Hits	367	Target Neighborhood Hits	191	Shared Neighborhood Hits	26
SwissProt Accessions	Q01755	Gene names	Tcp11
Domain Architecture
Description	Testis-specific protein PBS13.

ATX7_MOUSE
NC score	0.017130 (rank : 422)	θ value	6.88961 (rank : 309)
Query Neighborhood Hits	367	Target Neighborhood Hits	328	Shared Neighborhood Hits	49
SwissProt Accessions	Q8R4I1, Q8BL17	Gene names	Atxn7, Sca7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein homolog).

KIF1A_MOUSE
NC score	0.017000 (rank : 423)	θ value	1.06291 (rank : 215)
Query Neighborhood Hits	367	Target Neighborhood Hits	239	Shared Neighborhood Hits	22
SwissProt Accessions	P33173, Q61770	Gene names	Kif1a, Atsv, Kif1
Domain Architecture
Description	Kinesin-like protein KIF1A (Axonal transporter of synaptic vesicles).

SEM6D_HUMAN
NC score	0.016830 (rank : 424)	θ value	1.38821 (rank : 229)
Query Neighborhood Hits	367	Target Neighborhood Hits	169	Shared Neighborhood Hits	19
SwissProt Accessions	Q8NFY4, Q8NFY3, Q8NFY5, Q8NFY6, Q8NFY7, Q9P249	Gene names	SEMA6D, KIAA1479
Domain Architecture	No domain graphic available
Description	Semaphorin-6D precursor.

SEM6A_HUMAN
NC score	0.016765 (rank : 425)	θ value	0.365318 (rank : 179)
Query Neighborhood Hits	367	Target Neighborhood Hits	96	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H2E6, Q9P2H9	Gene names	SEMA6A, KIAA1368
Domain Architecture
Description	Semaphorin-6A precursor (Semaphorin VIA) (Sema VIA) (Semaphorin 6A-1) (SEMA6A-1).

GAK2_HUMAN
NC score	0.016717 (rank : 426)	θ value	6.88961 (rank : 318)
Query Neighborhood Hits	367	Target Neighborhood Hits	406	Shared Neighborhood Hits	43
SwissProt Accessions	Q7LDI9, Q9UKH5, Q9Y6I1, Q9YNA6, Q9YNB0	Gene names	ERVK6
Domain Architecture	No domain graphic available
Description	HERV-K_7p22.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K(C7) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GR65_HUMAN
NC score	0.016601 (rank : 427)	θ value	4.03905 (rank : 279)
Query Neighborhood Hits	367	Target Neighborhood Hits	148	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BQQ3, Q8N272, Q96H42	Gene names	GORASP1, GRASP65
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 1 (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5).

SEM6A_MOUSE
NC score	0.016531 (rank : 428)	θ value	0.365318 (rank : 180)
Query Neighborhood Hits	367	Target Neighborhood Hits	96	Shared Neighborhood Hits	10
SwissProt Accessions	O35464, Q6P5A8, Q6PCN9, Q9EQ71	Gene names	Sema6a, Semaq
Domain Architecture
Description	Semaphorin-6A precursor (Semaphorin VIA) (Sema VIA) (Semaphorin 6A-1) (SEMA6A-1) (Semaphorin Q) (Sema Q).

KIF1A_HUMAN
NC score	0.016067 (rank : 429)	θ value	1.38821 (rank : 225)
Query Neighborhood Hits	367	Target Neighborhood Hits	240	Shared Neighborhood Hits	22
SwissProt Accessions	Q12756	Gene names	KIF1A, ATSV
Domain Architecture
Description	Kinesin-like protein KIF1A (Axonal transporter of synaptic vesicles).

B4GN4_MOUSE
NC score	0.016015 (rank : 430)	θ value	1.38821 (rank : 218)
Query Neighborhood Hits	367	Target Neighborhood Hits	129	Shared Neighborhood Hits	17
SwissProt Accessions	Q766D5, Q8CHV2	Gene names	B4galnt4
Domain Architecture	No domain graphic available
Description	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferase 1 (EC 2.4.1.244) (NGalNAc-T1) (Beta- 1,4-N-acetylgalactosaminyltransferase IV) (Beta4GalNAc-T4) (Beta4GalNAcT4).

KIF1B_HUMAN
NC score	0.015724 (rank : 431)	θ value	1.81305 (rank : 235)
Query Neighborhood Hits	367	Target Neighborhood Hits	178	Shared Neighborhood Hits	19
SwissProt Accessions	O60333, Q96Q94, Q9BV80, Q9P280	Gene names	KIF1B, KIAA0591, KIAA1448
Domain Architecture
Description	Kinesin-like protein KIF1B (Klp).

CK056_MOUSE
NC score	0.015682 (rank : 432)	θ value	3.0926 (rank : 259)
Query Neighborhood Hits	367	Target Neighborhood Hits	42	Shared Neighborhood Hits	13
SwissProt Accessions	Q3U2I3, Q3TWF5, Q6P543, Q80T93, Q811J6, Q8BI34, Q8VE55	Gene names	Kiaa1759
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf56 homolog.

GAK1_HUMAN
NC score	0.015602 (rank : 433)	θ value	6.88961 (rank : 317)
Query Neighborhood Hits	367	Target Neighborhood Hits	268	Shared Neighborhood Hits	33
SwissProt Accessions	P62683	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_12q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GP153_HUMAN
NC score	0.015576 (rank : 434)	θ value	1.38821 (rank : 224)
Query Neighborhood Hits	367	Target Neighborhood Hits	332	Shared Neighborhood Hits	19
SwissProt Accessions	Q6NV75, Q5TGR5, Q6AHW8, Q86SP8	Gene names	GPR153, PGR1
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 153 (G-protein coupled receptor PGR1).

TPO_MOUSE
NC score	0.015297 (rank : 435)	θ value	8.99809 (rank : 365)
Query Neighborhood Hits	367	Target Neighborhood Hits	258	Shared Neighborhood Hits	25
SwissProt Accessions	P40226	Gene names	Thpo
Domain Architecture
Description	Thrombopoietin precursor (Megakaryocyte colony-stimulating factor) (Myeloproliferative leukemia virus oncogene ligand) (C-mpl ligand) (ML) (Megakaryocyte growth and development factor) (MGDF).

CD2_MOUSE
NC score	0.015166 (rank : 436)	θ value	4.03905 (rank : 273)
Query Neighborhood Hits	367	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	P08920, Q61394	Gene names	Cd2, Ly-37
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Lymphocyte antigen Ly-37).

CTRO_HUMAN
NC score	0.015162 (rank : 437)	θ value	8.99809 (rank : 343)
Query Neighborhood Hits	367	Target Neighborhood Hits	2092	Shared Neighborhood Hits	78
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

CSPG3_HUMAN
NC score	0.014890 (rank : 438)	θ value	0.279714 (rank : 163)
Query Neighborhood Hits	367	Target Neighborhood Hits	676	Shared Neighborhood Hits	41
SwissProt Accessions	O14594, Q9UPK6	Gene names	CSPG3, NCAN, NEUR
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

SEM6D_MOUSE
NC score	0.014848 (rank : 439)	θ value	1.81305 (rank : 239)
Query Neighborhood Hits	367	Target Neighborhood Hits	161	Shared Neighborhood Hits	20
SwissProt Accessions	Q76KF0, Q76KF1, Q76KF2, Q76KF3, Q76KF4, Q80TD0	Gene names	Sema6d, Kiaa1479
Domain Architecture	No domain graphic available
Description	Semaphorin-6D precursor.

KIF1B_MOUSE
NC score	0.014457 (rank : 440)	θ value	1.81305 (rank : 236)
Query Neighborhood Hits	367	Target Neighborhood Hits	167	Shared Neighborhood Hits	17
SwissProt Accessions	Q60575, Q9R0B4, Q9WVE5, Q9Z119	Gene names	Kif1b
Domain Architecture
Description	Kinesin-like protein KIF1B.

ERRFI_MOUSE
NC score	0.014343 (rank : 441)	θ value	5.27518 (rank : 293)
Query Neighborhood Hits	367	Target Neighborhood Hits	72	Shared Neighborhood Hits	16
SwissProt Accessions	Q99JZ7	Gene names	Errfi1, Mig6
Domain Architecture	No domain graphic available
Description	ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein homolog) (Mig-6).

GRB7_HUMAN
NC score	0.014207 (rank : 442)	θ value	6.88961 (rank : 320)
Query Neighborhood Hits	367	Target Neighborhood Hits	156	Shared Neighborhood Hits	14
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

ETV5_MOUSE
NC score	0.014015 (rank : 443)	θ value	0.47712 (rank : 183)
Query Neighborhood Hits	367	Target Neighborhood Hits	328	Shared Neighborhood Hits	45
SwissProt Accessions	Q9CXC9, Q3TG49, Q8C0F3, Q9JHB1	Gene names	Etv5
Domain Architecture	No domain graphic available
Description	ETS translocation variant 5.

AFF2_MOUSE
NC score	0.013353 (rank : 444)	θ value	8.99809 (rank : 336)
Query Neighborhood Hits	367	Target Neighborhood Hits	225	Shared Neighborhood Hits	29
SwissProt Accessions	O55112	Gene names	Aff2, Fmr2, Ox19
Domain Architecture
Description	AF4/FMR2 family member 2 (Fragile X mental retardation protein 2 homolog) (Protein FMR-2) (FMR2P) (Protein Ox19).

PNMA2_MOUSE
NC score	0.013010 (rank : 445)	θ value	2.36792 (rank : 253)
Query Neighborhood Hits	367	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BHK0	Gene names	Pnma2
Domain Architecture
Description	Paraneoplastic antigen Ma2 homolog.

MYO15_MOUSE
NC score	0.012936 (rank : 446)	θ value	8.99809 (rank : 356)
Query Neighborhood Hits	367	Target Neighborhood Hits	467	Shared Neighborhood Hits	73
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

TIF1G_MOUSE
NC score	0.012880 (rank : 447)	θ value	6.88961 (rank : 331)
Query Neighborhood Hits	367	Target Neighborhood Hits	498	Shared Neighborhood Hits	52
SwissProt Accessions	Q99PP7, Q6SI71, Q6ZPX5	Gene names	Trim33, Kiaa1113
Domain Architecture	No domain graphic available
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33).

CAC1G_HUMAN
NC score	0.012703 (rank : 448)	θ value	2.36792 (rank : 245)
Query Neighborhood Hits	367	Target Neighborhood Hits	587	Shared Neighborhood Hits	60
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

ELF1_MOUSE
NC score	0.012376 (rank : 449)	θ value	1.81305 (rank : 233)
Query Neighborhood Hits	367	Target Neighborhood Hits	139	Shared Neighborhood Hits	14
SwissProt Accessions	Q60775	Gene names	Elf1
Domain Architecture
Description	ETS-related transcription factor Elf-1 (E74-like factor 1).

ATX1_MOUSE
NC score	0.012014 (rank : 450)	θ value	6.88961 (rank : 308)
Query Neighborhood Hits	367	Target Neighborhood Hits	264	Shared Neighborhood Hits	30
SwissProt Accessions	P54254	Gene names	Atxn1, Sca1
Domain Architecture
Description	Ataxin-1 (Spinocerebellar ataxia type 1 protein homolog).

TIF1G_HUMAN
NC score	0.011857 (rank : 451)	θ value	6.88961 (rank : 330)
Query Neighborhood Hits	367	Target Neighborhood Hits	410	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UPN9, O95855, Q9C017, Q9UJ79	Gene names	TRIM33, KIAA1113, RFG7, TIF1G
Domain Architecture
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33) (RET-fused gene 7 protein) (Rfg7 protein).

ADA12_MOUSE
NC score	0.011760 (rank : 452)	θ value	0.21417 (rank : 153)
Query Neighborhood Hits	367	Target Neighborhood Hits	474	Shared Neighborhood Hits	41
SwissProt Accessions	Q61824	Gene names	Adam12, Mltna
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

KPCG_HUMAN
NC score	0.011755 (rank : 453)	θ value	8.99809 (rank : 351)
Query Neighborhood Hits	367	Target Neighborhood Hits	1126	Shared Neighborhood Hits	38
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

MYCB2_HUMAN
NC score	0.011376 (rank : 454)	θ value	6.88961 (rank : 325)
Query Neighborhood Hits	367	Target Neighborhood Hits	390	Shared Neighborhood Hits	40
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

CN044_MOUSE
NC score	0.011162 (rank : 455)	θ value	8.99809 (rank : 339)
Query Neighborhood Hits	367	Target Neighborhood Hits	57	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CB59, Q8BQX8, Q8BSL9, Q8CBZ3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf44 homolog.

OBSL1_HUMAN
NC score	0.010974 (rank : 456)	θ value	6.88961 (rank : 326)
Query Neighborhood Hits	367	Target Neighborhood Hits	354	Shared Neighborhood Hits	7
SwissProt Accessions	O75147, Q96IW3	Gene names	OBSL1, KIAA0657
Domain Architecture	No domain graphic available
Description	Obscurin-like protein 1 precursor.

KPCG_MOUSE
NC score	0.010838 (rank : 457)	θ value	8.99809 (rank : 352)
Query Neighborhood Hits	367	Target Neighborhood Hits	1123	Shared Neighborhood Hits	37
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

SPRE2_MOUSE
NC score	0.010816 (rank : 458)	θ value	6.88961 (rank : 328)
Query Neighborhood Hits	367	Target Neighborhood Hits	41	Shared Neighborhood Hits	5
SwissProt Accessions	Q924S7	Gene names	Spred2
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 2 (Spred-2).

KIF1C_MOUSE
NC score	0.010283 (rank : 459)	θ value	6.88961 (rank : 322)
Query Neighborhood Hits	367	Target Neighborhood Hits	171	Shared Neighborhood Hits	28
SwissProt Accessions	O35071, Q5SX62	Gene names	Kif1c
Domain Architecture	No domain graphic available
Description	Kinesin-like protein KIF1C.

PDLI7_HUMAN
NC score	0.010216 (rank : 460)	θ value	8.99809 (rank : 357)
Query Neighborhood Hits	367	Target Neighborhood Hits	547	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

APCD1_MOUSE
NC score	0.009979 (rank : 461)	θ value	4.03905 (rank : 272)
Query Neighborhood Hits	367	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q3U128, Q3TA99	Gene names	Apcdd1, Drapc1
Domain Architecture	No domain graphic available
Description	Protein APCDD1 precursor (Adenomatosis polyposis coli down-regulated 1 protein homolog).

FOXN1_HUMAN
NC score	0.008980 (rank : 462)	θ value	2.36792 (rank : 249)
Query Neighborhood Hits	367	Target Neighborhood Hits	377	Shared Neighborhood Hits	40
SwissProt Accessions	O15353, O15352	Gene names	FOXN1, WHN
Domain Architecture
Description	Forkhead box protein N1 (Transcription factor winged-helix nude).

UBQL3_HUMAN
NC score	0.008900 (rank : 463)	θ value	4.03905 (rank : 285)
Query Neighborhood Hits	367	Target Neighborhood Hits	141	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H347, Q9NRE0	Gene names	UBQLN3
Domain Architecture
Description	Ubiquilin-3.

DOK1_HUMAN
NC score	0.008281 (rank : 464)	θ value	5.27518 (rank : 292)
Query Neighborhood Hits	367	Target Neighborhood Hits	85	Shared Neighborhood Hits	12
SwissProt Accessions	Q99704, O43204, Q9UHG6	Gene names	DOK1
Domain Architecture
Description	Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62).

ROBO4_MOUSE
NC score	0.007945 (rank : 465)	θ value	6.88961 (rank : 327)
Query Neighborhood Hits	367	Target Neighborhood Hits	358	Shared Neighborhood Hits	17
SwissProt Accessions	Q8C310, Q9DBW1	Gene names	Robo4
Domain Architecture
Description	Roundabout homolog 4 precursor.

TRI37_HUMAN
NC score	0.007740 (rank : 466)	θ value	5.27518 (rank : 307)
Query Neighborhood Hits	367	Target Neighborhood Hits	307	Shared Neighborhood Hits	13
SwissProt Accessions	O94972, Q7Z3E6, Q8IYF7, Q8WYF7	Gene names	TRIM37, KIAA0898, MUL, POB1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37 (Mulibrey nanism protein).

DMRTD_MOUSE
NC score	0.007680 (rank : 467)	θ value	8.99809 (rank : 345)
Query Neighborhood Hits	367	Target Neighborhood Hits	72	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CGW9	Gene names	Dmrtc2, Dmrt7
Domain Architecture	No domain graphic available
Description	Doublesex- and mab-3-related transcription factor C2 (Doublesex- and mab-3-related transcription factor 7).

FHL5_MOUSE
NC score	0.007289 (rank : 468)	θ value	0.813845 (rank : 203)
Query Neighborhood Hits	367	Target Neighborhood Hits	463	Shared Neighborhood Hits	8
SwissProt Accessions	Q9WTX7	Gene names	Fhl5, Act
Domain Architecture	No domain graphic available
Description	Four and a half LIM domains protein 5 (FHL-5) (Activator of cAMP- responsive element modulator in testis) (Activator of CREM in testis).

RUNX3_HUMAN
NC score	0.006698 (rank : 469)	θ value	5.27518 (rank : 302)
Query Neighborhood Hits	367	Target Neighborhood Hits	96	Shared Neighborhood Hits	13
SwissProt Accessions	Q13761, Q12969, Q13760	Gene names	RUNX3, AML2, CBFA3, PEBP2A3
Domain Architecture
Description	Runt-related transcription factor 3 (Core-binding factor, alpha 3 subunit) (CBF-alpha 3) (Acute myeloid leukemia 2 protein) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEBP2-alpha C) (PEA2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit).

SVIL_HUMAN
NC score	0.006676 (rank : 470)	θ value	5.27518 (rank : 305)
Query Neighborhood Hits	367	Target Neighborhood Hits	232	Shared Neighborhood Hits	16
SwissProt Accessions	O95425, O60611, O60612, Q5VZK5, Q5VZK6, Q9H1R7	Gene names	SVIL
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

NOTC3_HUMAN
NC score	0.006086 (rank : 471)	θ value	0.813845 (rank : 206)
Query Neighborhood Hits	367	Target Neighborhood Hits	1062	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

FOG1_MOUSE
NC score	0.006056 (rank : 472)	θ value	4.03905 (rank : 278)
Query Neighborhood Hits	367	Target Neighborhood Hits	1237	Shared Neighborhood Hits	106
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

TERF2_HUMAN
NC score	0.005969 (rank : 473)	θ value	8.99809 (rank : 364)
Query Neighborhood Hits	367	Target Neighborhood Hits	102	Shared Neighborhood Hits	8
SwissProt Accessions	Q15554	Gene names	TERF2, TRF2
Domain Architecture
Description	Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein).

LEO1_HUMAN
NC score	0.005890 (rank : 474)	θ value	8.99809 (rank : 353)
Query Neighborhood Hits	367	Target Neighborhood Hits	958	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

IRX1_HUMAN
NC score	0.005889 (rank : 475)	θ value	4.03905 (rank : 280)
Query Neighborhood Hits	367	Target Neighborhood Hits	285	Shared Neighborhood Hits	19
SwissProt Accessions	P78414, Q7Z2F8, Q8N312	Gene names	IRX1, IRXA1
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-1 (Iroquois homeobox protein 1) (Homeodomain protein IRXA1).

NOTC3_MOUSE
NC score	0.005726 (rank : 476)	θ value	2.36792 (rank : 252)
Query Neighborhood Hits	367	Target Neighborhood Hits	975	Shared Neighborhood Hits	47
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

BRCA1_MOUSE
NC score	0.005540 (rank : 477)	θ value	5.27518 (rank : 286)
Query Neighborhood Hits	367	Target Neighborhood Hits	436	Shared Neighborhood Hits	22
SwissProt Accessions	P48754, Q60957, Q60983	Gene names	Brca1
Domain Architecture
Description	Breast cancer type 1 susceptibility protein homolog.

NOTC2_HUMAN
NC score	0.005185 (rank : 478)	θ value	5.27518 (rank : 298)
Query Neighborhood Hits	367	Target Neighborhood Hits	1113	Shared Neighborhood Hits	55
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

CAC1B_HUMAN
NC score	0.005165 (rank : 479)	θ value	5.27518 (rank : 287)
Query Neighborhood Hits	367	Target Neighborhood Hits	257	Shared Neighborhood Hits	28
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

MYLK_MOUSE
NC score	0.004463 (rank : 480)	θ value	5.27518 (rank : 296)
Query Neighborhood Hits	367	Target Neighborhood Hits	1489	Shared Neighborhood Hits	57
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

STON1_HUMAN
NC score	0.004259 (rank : 481)	θ value	8.99809 (rank : 362)
Query Neighborhood Hits	367	Target Neighborhood Hits	49	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y6Q2, Q96JE3, Q9BYX3	Gene names	STON1, SALF, SBLF, STN1
Domain Architecture
Description	Stonin-1 (Stoned B-like factor).

ST2B1_HUMAN
NC score	0.004187 (rank : 482)	θ value	5.27518 (rank : 304)
Query Neighborhood Hits	367	Target Neighborhood Hits	57	Shared Neighborhood Hits	12
SwissProt Accessions	O00204, O00205, O75814	Gene names	SULT2B1, HSST2
Domain Architecture	No domain graphic available
Description	Sulfotransferase family cytosolic 2B member 1 (EC 2.8.2.2) (Sulfotransferase 2B1) (Alcohol sulfotransferase) (Hydroxysteroid sulfotransferase 2).

PKD2_HUMAN
NC score	0.004048 (rank : 483)	θ value	5.27518 (rank : 300)
Query Neighborhood Hits	367	Target Neighborhood Hits	105	Shared Neighborhood Hits	6
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

GRIK5_MOUSE
NC score	0.003598 (rank : 484)	θ value	3.0926 (rank : 266)
Query Neighborhood Hits	367	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	Q61626	Gene names	Grik5
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 5 precursor (Glutamate receptor KA-2) (KA2) (Glutamate receptor gamma-2) (GluR gamma-2).

GRIK5_HUMAN
NC score	0.003088 (rank : 485)	θ value	5.27518 (rank : 295)
Query Neighborhood Hits	367	Target Neighborhood Hits	44	Shared Neighborhood Hits	4
SwissProt Accessions	Q16478	Gene names	GRIK5, GRIK2
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 5 precursor (Glutamate receptor KA-2) (KA2) (Excitatory amino acid receptor 2) (EAA2).

SMAD1_HUMAN
NC score	0.002974 (rank : 486)	θ value	8.99809 (rank : 360)
Query Neighborhood Hits	367	Target Neighborhood Hits	59	Shared Neighborhood Hits	12
SwissProt Accessions	Q15797, Q16636	Gene names	SMAD1, BSP1, MADH1, MADR1
Domain Architecture
Description	Mothers against decapentaplegic homolog 1 (SMAD 1) (Mothers against DPP homolog 1) (Mad-related protein 1) (Transforming growth factor- beta signaling protein 1) (BSP-1) (hSMAD1) (JV4-1).

ULK1_MOUSE
NC score	0.002939 (rank : 487)	θ value	1.81305 (rank : 242)
Query Neighborhood Hits	367	Target Neighborhood Hits	1214	Shared Neighborhood Hits	62
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

HEM1_HUMAN
NC score	0.002757 (rank : 488)	θ value	8.99809 (rank : 349)
Query Neighborhood Hits	367	Target Neighborhood Hits	45	Shared Neighborhood Hits	3
SwissProt Accessions	P13196	Gene names	ALAS1, ALASH
Domain Architecture
Description	5-aminolevulinate synthase, nonspecific, mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta-aminolevulinate synthase) (Delta-ALA synthetase) (ALAS-H).

OST3B_HUMAN
NC score	0.002698 (rank : 489)	θ value	5.27518 (rank : 299)
Query Neighborhood Hits	367	Target Neighborhood Hits	51	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y662	Gene names	HS3ST3B1, 3OST3B1, HS3ST3B
Domain Architecture	No domain graphic available
Description	Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 (EC 2.8.2.30) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1) (Heparan sulfate 3-O-sulfotransferase 3B1) (h3-OST-3B).

ZN516_MOUSE
NC score	0.002542 (rank : 490)	θ value	0.813845 (rank : 211)
Query Neighborhood Hits	367	Target Neighborhood Hits	1197	Shared Neighborhood Hits	84
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

WNT5A_MOUSE
NC score	0.002507 (rank : 491)	θ value	6.88961 (rank : 334)
Query Neighborhood Hits	367	Target Neighborhood Hits	48	Shared Neighborhood Hits	5
SwissProt Accessions	P22725	Gene names	Wnt5a, Wnt-5a
Domain Architecture
Description	Protein Wnt-5a precursor.

WNT5A_HUMAN
NC score	0.002496 (rank : 492)	θ value	6.88961 (rank : 333)
Query Neighborhood Hits	367	Target Neighborhood Hits	48	Shared Neighborhood Hits	5
SwissProt Accessions	P41221	Gene names	WNT5A
Domain Architecture
Description	Protein Wnt-5a precursor.

SBK1_HUMAN
NC score	0.002263 (rank : 493)	θ value	8.99809 (rank : 359)
Query Neighborhood Hits	367	Target Neighborhood Hits	828	Shared Neighborhood Hits	19
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

KS6A4_MOUSE
NC score	0.001777 (rank : 494)	θ value	0.365318 (rank : 176)
Query Neighborhood Hits	367	Target Neighborhood Hits	866	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

UBP21_HUMAN
NC score	0.001414 (rank : 495)	θ value	8.99809 (rank : 366)
Query Neighborhood Hits	367	Target Neighborhood Hits	95	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UK80, Q9BTV1, Q9NYN4	Gene names	USP21, USP23
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.1.2.15) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21) (Deubiquitinating enzyme 21) (NEDD8-specific protease).

ITA1_HUMAN
NC score	0.001174 (rank : 496)	θ value	8.99809 (rank : 350)
Query Neighborhood Hits	367	Target Neighborhood Hits	75	Shared Neighborhood Hits	7
SwissProt Accessions	P56199	Gene names	ITGA1
Domain Architecture	No domain graphic available
Description	Integrin alpha-1 (Laminin and collagen receptor) (VLA-1) (CD49a antigen).

MARK3_HUMAN
NC score	0.000073 (rank : 497)	θ value	4.03905 (rank : 282)
Query Neighborhood Hits	367	Target Neighborhood Hits	893	Shared Neighborhood Hits	17
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

FHL5_HUMAN
NC score	-0.000393 (rank : 498)	θ value	8.99809 (rank : 347)
Query Neighborhood Hits	367	Target Neighborhood Hits	523	Shared Neighborhood Hits	7
SwissProt Accessions	Q5TD97, Q5TD98, Q8WW21, Q9NQU2	Gene names	FHL5, ACT
Domain Architecture	No domain graphic available
Description	Four and a half LIM domains protein 5 (FHL-5) (Activator of cAMP- responsive element modulator in testis) (Activator of CREM in testis).

MK15_HUMAN
NC score	-0.001004 (rank : 499)	θ value	8.99809 (rank : 354)
Query Neighborhood Hits	367	Target Neighborhood Hits	1038	Shared Neighborhood Hits	46
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

SUHW3_HUMAN
NC score	-0.003239 (rank : 500)	θ value	6.88961 (rank : 329)
Query Neighborhood Hits	367	Target Neighborhood Hits	695	Shared Neighborhood Hits	16
SwissProt Accessions	Q8ND82, Q9NXR3	Gene names	SUHW3
Domain Architecture	No domain graphic available
Description	Suppressor of hairy wing homolog 3.

TCF8_MOUSE
NC score	-0.004200 (rank : 501)	θ value	5.27518 (rank : 306)
Query Neighborhood Hits	367	Target Neighborhood Hits	1067	Shared Neighborhood Hits	36
SwissProt Accessions	Q64318, Q62519	Gene names	Tcf8, Zfhx1a, Zfx1a, Zfx1ha
Domain Architecture
Description	Transcription factor 8 (Zinc finger homeobox protein 1a) (MEB1) (Delta EF1).

ZBT12_HUMAN
NC score	-0.005318 (rank : 502)	θ value	3.0926 (rank : 270)
Query Neighborhood Hits	367	Target Neighborhood Hits	784	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y330, Q5JQ98	Gene names	ZBTB12, C6orf46, G10, NG35
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 12 (Protein G10).

ZN142_HUMAN
NC score	-0.005554 (rank : 503)	θ value	8.99809 (rank : 367)
Query Neighborhood Hits	367	Target Neighborhood Hits	1007	Shared Neighborhood Hits	56
SwissProt Accessions	P52746, Q92510	Gene names	ZNF142, KIAA0236
Domain Architecture	No domain graphic available
Description	Zinc finger protein 142 (HA4654).

ZBT7A_HUMAN
NC score	-0.006838 (rank : 504)	θ value	0.813845 (rank : 210)
Query Neighborhood Hits	367	Target Neighborhood Hits	823	Shared Neighborhood Hits	14
SwissProt Accessions	O95365, O00456	Gene names	ZBTB7A, FBI1, LRF, ZBTB7
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 7A (Leukemia/lymphoma- related factor) (Factor that binds to inducer of short transcripts protein 1) (Factor binding IST protein 1) (FBI-1) (HIV-1 1st-binding protein 1) (TTF-I-interacting peptide 21) (TIP21).

ZN564_HUMAN
NC score	-0.007912 (rank : 505)	θ value	6.88961 (rank : 335)
Query Neighborhood Hits	367	Target Neighborhood Hits	746	Shared Neighborhood Hits	15
SwissProt Accessions	Q8TBZ8	Gene names	ZNF564
Domain Architecture	No domain graphic available
Description	Zinc finger protein 564.