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Network neighborhood for query Sequence : CEND1_MOUSE

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CEND1_MOUSE
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CEND1_HUMAN
θ value	0 (rank : 1)	NC score	0.987894 (rank : 2)
Query Neighborhood Hits	260	Target Neighborhood Hits	284	Shared Neighborhood Hits	196
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CEND1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	260	Target Neighborhood Hits	260	Shared Neighborhood Hits	260
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CEND2_HUMAN
θ value	0 (rank : 3)	NC score	0.953264 (rank : 3)
Query Neighborhood Hits	260	Target Neighborhood Hits	166	Shared Neighborhood Hits	132
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

CEND3_HUMAN
θ value	0 (rank : 4)	NC score	0.942897 (rank : 5)
Query Neighborhood Hits	260	Target Neighborhood Hits	275	Shared Neighborhood Hits	136
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CEND3_MOUSE
θ value	0 (rank : 5)	NC score	0.945697 (rank : 4)
Query Neighborhood Hits	260	Target Neighborhood Hits	228	Shared Neighborhood Hits	139
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CENB2_HUMAN
θ value	4.9032e-22 (rank : 6)	NC score	0.509672 (rank : 36)
Query Neighborhood Hits	260	Target Neighborhood Hits	425	Shared Neighborhood Hits	90
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENG1_MOUSE
θ value	4.15078e-21 (rank : 7)	NC score	0.511463 (rank : 34)
Query Neighborhood Hits	260	Target Neighborhood Hits	531	Shared Neighborhood Hits	56
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

CENG1_HUMAN
θ value	7.0802e-21 (rank : 8)	NC score	0.506056 (rank : 40)
Query Neighborhood Hits	260	Target Neighborhood Hits	544	Shared Neighborhood Hits	55
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

CENB5_HUMAN
θ value	9.24701e-21 (rank : 9)	NC score	0.511814 (rank : 33)
Query Neighborhood Hits	260	Target Neighborhood Hits	395	Shared Neighborhood Hits	87
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CENG2_HUMAN
θ value	7.82807e-20 (rank : 10)	NC score	0.475294 (rank : 62)
Query Neighborhood Hits	260	Target Neighborhood Hits	471	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

CENG3_HUMAN
θ value	1.33526e-19 (rank : 11)	NC score	0.498670 (rank : 46)
Query Neighborhood Hits	260	Target Neighborhood Hits	455	Shared Neighborhood Hits	53
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_MOUSE
θ value	1.33526e-19 (rank : 12)	NC score	0.498236 (rank : 47)
Query Neighborhood Hits	260	Target Neighborhood Hits	467	Shared Neighborhood Hits	55
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG2_MOUSE
θ value	1.74391e-19 (rank : 13)	NC score	0.477878 (rank : 61)
Query Neighborhood Hits	260	Target Neighborhood Hits	463	Shared Neighborhood Hits	54
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

CENB1_HUMAN
θ value	5.07402e-19 (rank : 14)	NC score	0.512123 (rank : 32)
Query Neighborhood Hits	260	Target Neighborhood Hits	383	Shared Neighborhood Hits	86
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

DDEF2_MOUSE
θ value	2.13179e-17 (rank : 15)	NC score	0.488960 (rank : 54)
Query Neighborhood Hits	260	Target Neighborhood Hits	625	Shared Neighborhood Hits	74
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDFL1_MOUSE
θ value	2.7842e-17 (rank : 16)	NC score	0.510282 (rank : 35)
Query Neighborhood Hits	260	Target Neighborhood Hits	324	Shared Neighborhood Hits	61
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

DDEF2_HUMAN
θ value	6.20254e-17 (rank : 17)	NC score	0.492697 (rank : 49)
Query Neighborhood Hits	260	Target Neighborhood Hits	599	Shared Neighborhood Hits	74
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF1_MOUSE
θ value	3.07829e-16 (rank : 18)	NC score	0.501178 (rank : 43)
Query Neighborhood Hits	260	Target Neighborhood Hits	592	Shared Neighborhood Hits	69
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

MYO9B_HUMAN
θ value	3.07829e-16 (rank : 19)	NC score	0.298775 (rank : 89)
Query Neighborhood Hits	260	Target Neighborhood Hits	641	Shared Neighborhood Hits	76
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

MYO9B_MOUSE
θ value	1.52774e-15 (rank : 20)	NC score	0.301387 (rank : 88)
Query Neighborhood Hits	260	Target Neighborhood Hits	311	Shared Neighborhood Hits	64
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

GIT2_MOUSE
θ value	3.40345e-15 (rank : 21)	NC score	0.472175 (rank : 64)
Query Neighborhood Hits	260	Target Neighborhood Hits	323	Shared Neighborhood Hits	47
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

DDFL1_HUMAN
θ value	7.58209e-15 (rank : 22)	NC score	0.531905 (rank : 23)
Query Neighborhood Hits	260	Target Neighborhood Hits	353	Shared Neighborhood Hits	67
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

GIT1_HUMAN
θ value	1.68911e-14 (rank : 23)	NC score	0.462997 (rank : 68)
Query Neighborhood Hits	260	Target Neighborhood Hits	336	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

GIT1_MOUSE
θ value	1.68911e-14 (rank : 24)	NC score	0.461441 (rank : 69)
Query Neighborhood Hits	260	Target Neighborhood Hits	341	Shared Neighborhood Hits	48
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

ABR_HUMAN
θ value	2.20605e-14 (rank : 25)	NC score	0.502393 (rank : 41)
Query Neighborhood Hits	260	Target Neighborhood Hits	166	Shared Neighborhood Hits	66
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

GIT2_HUMAN
θ value	2.88119e-14 (rank : 26)	NC score	0.473232 (rank : 63)
Query Neighborhood Hits	260	Target Neighborhood Hits	381	Shared Neighborhood Hits	51
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

SMAP1_MOUSE
θ value	3.76295e-14 (rank : 27)	NC score	0.585912 (rank : 8)
Query Neighborhood Hits	260	Target Neighborhood Hits	120	Shared Neighborhood Hits	40
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

RHG05_MOUSE
θ value	6.41864e-14 (rank : 28)	NC score	0.531131 (rank : 26)
Query Neighborhood Hits	260	Target Neighborhood Hits	165	Shared Neighborhood Hits	64
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG05_HUMAN
θ value	1.86753e-13 (rank : 29)	NC score	0.527823 (rank : 29)
Query Neighborhood Hits	260	Target Neighborhood Hits	158	Shared Neighborhood Hits	62
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG09_HUMAN
θ value	1.86753e-13 (rank : 30)	NC score	0.574390 (rank : 11)
Query Neighborhood Hits	260	Target Neighborhood Hits	186	Shared Neighborhood Hits	62
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

BCR_HUMAN
θ value	2.43908e-13 (rank : 31)	NC score	0.492928 (rank : 48)
Query Neighborhood Hits	260	Target Neighborhood Hits	204	Shared Neighborhood Hits	67
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

SMP1L_MOUSE
θ value	2.43908e-13 (rank : 32)	NC score	0.586895 (rank : 7)
Query Neighborhood Hits	260	Target Neighborhood Hits	70	Shared Neighborhood Hits	38
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

SMAP1_HUMAN
θ value	3.18553e-13 (rank : 33)	NC score	0.583470 (rank : 9)
Query Neighborhood Hits	260	Target Neighborhood Hits	98	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IYB5, Q53H70, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4	Gene names	SMAP1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMP1L_HUMAN
θ value	3.18553e-13 (rank : 34)	NC score	0.587481 (rank : 6)
Query Neighborhood Hits	260	Target Neighborhood Hits	74	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

GMIP_MOUSE
θ value	4.16044e-13 (rank : 35)	NC score	0.550721 (rank : 13)
Query Neighborhood Hits	260	Target Neighborhood Hits	202	Shared Neighborhood Hits	64
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

SRGP1_HUMAN
θ value	2.69671e-12 (rank : 36)	NC score	0.460482 (rank : 70)
Query Neighborhood Hits	260	Target Neighborhood Hits	390	Shared Neighborhood Hits	67
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

CHIN_MOUSE
θ value	3.52202e-12 (rank : 37)	NC score	0.491219 (rank : 50)
Query Neighborhood Hits	260	Target Neighborhood Hits	229	Shared Neighborhood Hits	61
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

RBP1_HUMAN
θ value	6.00763e-12 (rank : 38)	NC score	0.489321 (rank : 53)
Query Neighborhood Hits	260	Target Neighborhood Hits	521	Shared Neighborhood Hits	76
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RBP1_MOUSE
θ value	7.84624e-12 (rank : 39)	NC score	0.500570 (rank : 44)
Query Neighborhood Hits	260	Target Neighborhood Hits	493	Shared Neighborhood Hits	77
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RHG04_HUMAN
θ value	7.84624e-12 (rank : 40)	NC score	0.479120 (rank : 60)
Query Neighborhood Hits	260	Target Neighborhood Hits	307	Shared Neighborhood Hits	59
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

CHIN_HUMAN
θ value	1.33837e-11 (rank : 41)	NC score	0.487639 (rank : 55)
Query Neighborhood Hits	260	Target Neighborhood Hits	227	Shared Neighborhood Hits	60
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

RGAP1_MOUSE
θ value	1.74796e-11 (rank : 42)	NC score	0.548346 (rank : 15)
Query Neighborhood Hits	260	Target Neighborhood Hits	185	Shared Neighborhood Hits	62
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

SRGP2_HUMAN
θ value	1.74796e-11 (rank : 43)	NC score	0.469070 (rank : 65)
Query Neighborhood Hits	260	Target Neighborhood Hits	331	Shared Neighborhood Hits	62
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

RHG12_HUMAN
θ value	2.98157e-11 (rank : 44)	NC score	0.530899 (rank : 27)
Query Neighborhood Hits	260	Target Neighborhood Hits	190	Shared Neighborhood Hits	62
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	2.98157e-11 (rank : 45)	NC score	0.530559 (rank : 28)
Query Neighborhood Hits	260	Target Neighborhood Hits	204	Shared Neighborhood Hits	64
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

CHIO_HUMAN
θ value	3.89403e-11 (rank : 46)	NC score	0.486451 (rank : 57)
Query Neighborhood Hits	260	Target Neighborhood Hits	220	Shared Neighborhood Hits	60
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

FNBP2_HUMAN
θ value	3.89403e-11 (rank : 47)	NC score	0.459953 (rank : 71)
Query Neighborhood Hits	260	Target Neighborhood Hits	432	Shared Neighborhood Hits	68
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

CHIO_MOUSE
θ value	6.64225e-11 (rank : 48)	NC score	0.508575 (rank : 38)
Query Neighborhood Hits	260	Target Neighborhood Hits	130	Shared Neighborhood Hits	59
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

RHG06_HUMAN
θ value	6.64225e-11 (rank : 49)	NC score	0.532979 (rank : 22)
Query Neighborhood Hits	260	Target Neighborhood Hits	114	Shared Neighborhood Hits	59
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

SRGP2_MOUSE
θ value	6.64225e-11 (rank : 50)	NC score	0.463555 (rank : 67)
Query Neighborhood Hits	260	Target Neighborhood Hits	324	Shared Neighborhood Hits	64
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

GMIP_HUMAN
θ value	8.67504e-11 (rank : 51)	NC score	0.535983 (rank : 19)
Query Neighborhood Hits	260	Target Neighborhood Hits	225	Shared Neighborhood Hits	62
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

RHG06_MOUSE
θ value	1.133e-10 (rank : 52)	NC score	0.531863 (rank : 24)
Query Neighborhood Hits	260	Target Neighborhood Hits	105	Shared Neighborhood Hits	58
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

CENA1_HUMAN
θ value	2.52405e-10 (rank : 53)	NC score	0.579599 (rank : 10)
Query Neighborhood Hits	260	Target Neighborhood Hits	87	Shared Neighborhood Hits	66
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

RGAP1_HUMAN
θ value	3.29651e-10 (rank : 54)	NC score	0.544324 (rank : 17)
Query Neighborhood Hits	260	Target Neighborhood Hits	189	Shared Neighborhood Hits	61
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

GRLF1_HUMAN
θ value	4.30538e-10 (rank : 55)	NC score	0.531384 (rank : 25)
Query Neighborhood Hits	260	Target Neighborhood Hits	167	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

OPHN1_MOUSE
θ value	5.62301e-10 (rank : 56)	NC score	0.557506 (rank : 12)
Query Neighborhood Hits	260	Target Neighborhood Hits	174	Shared Neighborhood Hits	67
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

TCGAP_HUMAN
θ value	1.63604e-09 (rank : 57)	NC score	0.455514 (rank : 72)
Query Neighborhood Hits	260	Target Neighborhood Hits	872	Shared Neighborhood Hits	73
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	1.63604e-09 (rank : 58)	NC score	0.501698 (rank : 42)
Query Neighborhood Hits	260	Target Neighborhood Hits	409	Shared Neighborhood Hits	63
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

OPHN1_HUMAN
θ value	2.13673e-09 (rank : 59)	NC score	0.548463 (rank : 14)
Query Neighborhood Hits	260	Target Neighborhood Hits	161	Shared Neighborhood Hits	64
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

CENA2_HUMAN
θ value	2.79066e-09 (rank : 60)	NC score	0.546020 (rank : 16)
Query Neighborhood Hits	260	Target Neighborhood Hits	83	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

TAGAP_HUMAN
θ value	6.21693e-09 (rank : 61)	NC score	0.489355 (rank : 52)
Query Neighborhood Hits	260	Target Neighborhood Hits	82	Shared Neighborhood Hits	55
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

CENA2_MOUSE
θ value	8.11959e-09 (rank : 62)	NC score	0.541948 (rank : 18)
Query Neighborhood Hits	260	Target Neighborhood Hits	68	Shared Neighborhood Hits	54
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

ARFG3_MOUSE
θ value	1.38499e-08 (rank : 63)	NC score	0.534963 (rank : 20)
Query Neighborhood Hits	260	Target Neighborhood Hits	80	Shared Neighborhood Hits	40
SwissProt Accessions	Q9D8S3, Q99KN8	Gene names	Arfgap3
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

RHG26_HUMAN
θ value	2.36244e-08 (rank : 64)	NC score	0.513584 (rank : 31)
Query Neighborhood Hits	260	Target Neighborhood Hits	281	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

ARFG3_HUMAN
θ value	6.87365e-08 (rank : 65)	NC score	0.534372 (rank : 21)
Query Neighborhood Hits	260	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

RHG01_HUMAN
θ value	6.87365e-08 (rank : 66)	NC score	0.483192 (rank : 58)
Query Neighborhood Hits	260	Target Neighborhood Hits	75	Shared Neighborhood Hits	58
SwissProt Accessions	Q07960	Gene names	ARHGAP1, CDC42GAP, RHOGAP1
Domain Architecture
Description	Rho-GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (CDC42 GTPase-activating protein) (p50-RhoGAP).

RHG18_MOUSE
θ value	6.87365e-08 (rank : 67)	NC score	0.499829 (rank : 45)
Query Neighborhood Hits	260	Target Neighborhood Hits	110	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

RHG18_HUMAN
θ value	3.41135e-07 (rank : 68)	NC score	0.506620 (rank : 39)
Query Neighborhood Hits	260	Target Neighborhood Hits	90	Shared Neighborhood Hits	57
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

TAGAP_MOUSE
θ value	1.29631e-06 (rank : 69)	NC score	0.480414 (rank : 59)
Query Neighborhood Hits	260	Target Neighborhood Hits	83	Shared Neighborhood Hits	57
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

ARFG1_HUMAN
θ value	1.69304e-06 (rank : 70)	NC score	0.508753 (rank : 37)
Query Neighborhood Hits	260	Target Neighborhood Hits	60	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N6T3, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0	Gene names	ARFGAP1, ARF1GAP
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

ARFG1_MOUSE
θ value	2.21117e-06 (rank : 71)	NC score	0.521890 (rank : 30)
Query Neighborhood Hits	260	Target Neighborhood Hits	51	Shared Neighborhood Hits	39
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

P85A_HUMAN
θ value	2.21117e-06 (rank : 72)	NC score	0.274647 (rank : 90)
Query Neighborhood Hits	260	Target Neighborhood Hits	479	Shared Neighborhood Hits	66
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

3BP1_HUMAN
θ value	2.88788e-06 (rank : 73)	NC score	0.487107 (rank : 56)
Query Neighborhood Hits	260	Target Neighborhood Hits	376	Shared Neighborhood Hits	68
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

RHG25_MOUSE
θ value	2.88788e-06 (rank : 74)	NC score	0.469027 (rank : 66)
Query Neighborhood Hits	260	Target Neighborhood Hits	492	Shared Neighborhood Hits	117
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

MYO10_HUMAN
θ value	4.92598e-06 (rank : 75)	NC score	0.092022 (rank : 117)
Query Neighborhood Hits	260	Target Neighborhood Hits	920	Shared Neighborhood Hits	90
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

P85A_MOUSE
θ value	1.09739e-05 (rank : 76)	NC score	0.268628 (rank : 91)
Query Neighborhood Hits	260	Target Neighborhood Hits	435	Shared Neighborhood Hits	64
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

RHG08_HUMAN
θ value	1.87187e-05 (rank : 77)	NC score	0.455266 (rank : 73)
Query Neighborhood Hits	260	Target Neighborhood Hits	88	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NSG0, O75983, O95695, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NVX8, Q9NXL1, Q9UH20	Gene names	ARHGAP8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

CE005_HUMAN
θ value	2.44474e-05 (rank : 78)	NC score	0.392002 (rank : 77)
Query Neighborhood Hits	260	Target Neighborhood Hits	213	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

CE005_MOUSE
θ value	2.44474e-05 (rank : 79)	NC score	0.389520 (rank : 78)
Query Neighborhood Hits	260	Target Neighborhood Hits	238	Shared Neighborhood Hits	65
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

RHG08_MOUSE
θ value	3.19293e-05 (rank : 80)	NC score	0.455219 (rank : 74)
Query Neighborhood Hits	260	Target Neighborhood Hits	73	Shared Neighborhood Hits	58
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

3BP1_MOUSE
θ value	4.1701e-05 (rank : 81)	NC score	0.490134 (rank : 51)
Query Neighborhood Hits	260	Target Neighborhood Hits	238	Shared Neighborhood Hits	66
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

NUPL_HUMAN
θ value	4.1701e-05 (rank : 82)	NC score	0.379255 (rank : 80)
Query Neighborhood Hits	260	Target Neighborhood Hits	68	Shared Neighborhood Hits	37
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).

NUPL_MOUSE
θ value	4.1701e-05 (rank : 83)	NC score	0.375498 (rank : 81)
Query Neighborhood Hits	260	Target Neighborhood Hits	113	Shared Neighborhood Hits	36
SwissProt Accessions	Q8K2K6, O70448, Q8BQL5, Q8CDK9	Gene names	Hrb, Rip
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein homolog).

PKHA1_MOUSE
θ value	9.29e-05 (rank : 84)	NC score	0.240113 (rank : 95)
Query Neighborhood Hits	260	Target Neighborhood Hits	120	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_HUMAN
θ value	0.00020696 (rank : 85)	NC score	0.244032 (rank : 94)
Query Neighborhood Hits	260	Target Neighborhood Hits	127	Shared Neighborhood Hits	63
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA6_HUMAN
θ value	0.000461057 (rank : 86)	NC score	0.194632 (rank : 98)
Query Neighborhood Hits	260	Target Neighborhood Hits	556	Shared Neighborhood Hits	71
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

EPHA1_MOUSE
θ value	0.00102713 (rank : 87)	NC score	0.043628 (rank : 218)
Query Neighborhood Hits	260	Target Neighborhood Hits	958	Shared Neighborhood Hits	39
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

PKHA6_MOUSE
θ value	0.00102713 (rank : 88)	NC score	0.195697 (rank : 97)
Query Neighborhood Hits	260	Target Neighborhood Hits	591	Shared Neighborhood Hits	72
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

RHG07_MOUSE
θ value	0.00134147 (rank : 89)	NC score	0.395113 (rank : 76)
Query Neighborhood Hits	260	Target Neighborhood Hits	103	Shared Neighborhood Hits	60
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

RHG07_HUMAN
θ value	0.00175202 (rank : 90)	NC score	0.389164 (rank : 79)
Query Neighborhood Hits	260	Target Neighborhood Hits	108	Shared Neighborhood Hits	59
SwissProt Accessions	Q96QB1, O14868, O43199, Q9C0E0	Gene names	DLC1, ARHGAP7, KIAA1723, STARD12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

EPHA1_HUMAN
θ value	0.00390308 (rank : 91)	NC score	0.042248 (rank : 219)
Query Neighborhood Hits	260	Target Neighborhood Hits	997	Shared Neighborhood Hits	39
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

RASA3_HUMAN
θ value	0.00869519 (rank : 92)	NC score	0.083706 (rank : 120)
Query Neighborhood Hits	260	Target Neighborhood Hits	166	Shared Neighborhood Hits	39
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

DGKH_HUMAN
θ value	0.0148317 (rank : 93)	NC score	0.126806 (rank : 105)
Query Neighborhood Hits	260	Target Neighborhood Hits	255	Shared Neighborhood Hits	77
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

EPHA4_HUMAN
θ value	0.0148317 (rank : 94)	NC score	0.042229 (rank : 220)
Query Neighborhood Hits	260	Target Neighborhood Hits	975	Shared Neighborhood Hits	40
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

HRBL_HUMAN
θ value	0.0148317 (rank : 95)	NC score	0.324189 (rank : 86)
Query Neighborhood Hits	260	Target Neighborhood Hits	179	Shared Neighborhood Hits	37
SwissProt Accessions	O95081, O75429, Q96AB9, Q96GL4	Gene names	HRBL, RABR
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

STA13_HUMAN
θ value	0.0193708 (rank : 96)	NC score	0.356028 (rank : 82)
Query Neighborhood Hits	260	Target Neighborhood Hits	89	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

STA13_MOUSE
θ value	0.0193708 (rank : 97)	NC score	0.352427 (rank : 83)
Query Neighborhood Hits	260	Target Neighborhood Hits	89	Shared Neighborhood Hits	56
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

GAB2_HUMAN
θ value	0.0252991 (rank : 98)	NC score	0.111959 (rank : 106)
Query Neighborhood Hits	260	Target Neighborhood Hits	188	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

HRBL_MOUSE
θ value	0.0252991 (rank : 99)	NC score	0.308890 (rank : 87)
Query Neighborhood Hits	260	Target Neighborhood Hits	269	Shared Neighborhood Hits	38
SwissProt Accessions	Q80WC7, Q8BKS5, Q99J67	Gene names	Hrbl, Rabr
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

MRIP_MOUSE
θ value	0.0252991 (rank : 100)	NC score	0.075830 (rank : 132)
Query Neighborhood Hits	260	Target Neighborhood Hits	569	Shared Neighborhood Hits	62
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

SWP70_MOUSE
θ value	0.0330416 (rank : 101)	NC score	0.076987 (rank : 128)
Query Neighborhood Hits	260	Target Neighborhood Hits	1097	Shared Neighborhood Hits	88
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

PKHA2_MOUSE
θ value	0.0431538 (rank : 102)	NC score	0.200229 (rank : 96)
Query Neighborhood Hits	260	Target Neighborhood Hits	116	Shared Neighborhood Hits	57
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

AB1IP_HUMAN
θ value	0.0563607 (rank : 103)	NC score	0.074948 (rank : 134)
Query Neighborhood Hits	260	Target Neighborhood Hits	213	Shared Neighborhood Hits	18
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

AB1IP_MOUSE
θ value	0.0563607 (rank : 104)	NC score	0.074162 (rank : 135)
Query Neighborhood Hits	260	Target Neighborhood Hits	181	Shared Neighborhood Hits	16
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

CP250_MOUSE
θ value	0.0563607 (rank : 105)	NC score	0.021817 (rank : 252)
Query Neighborhood Hits	260	Target Neighborhood Hits	1583	Shared Neighborhood Hits	58
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

FGD4_MOUSE
θ value	0.0563607 (rank : 106)	NC score	0.062241 (rank : 161)
Query Neighborhood Hits	260	Target Neighborhood Hits	227	Shared Neighborhood Hits	48
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

DGKK_HUMAN
θ value	0.0736092 (rank : 107)	NC score	0.055352 (rank : 177)
Query Neighborhood Hits	260	Target Neighborhood Hits	378	Shared Neighborhood Hits	28
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

EPHB6_HUMAN
θ value	0.0736092 (rank : 108)	NC score	0.047421 (rank : 215)
Query Neighborhood Hits	260	Target Neighborhood Hits	912	Shared Neighborhood Hits	41
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

RASA2_MOUSE
θ value	0.0736092 (rank : 109)	NC score	0.078880 (rank : 125)
Query Neighborhood Hits	260	Target Neighborhood Hits	159	Shared Neighborhood Hits	39
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

SMC1A_HUMAN
θ value	0.0736092 (rank : 110)	NC score	0.024376 (rank : 246)
Query Neighborhood Hits	260	Target Neighborhood Hits	1346	Shared Neighborhood Hits	42
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

SMC1A_MOUSE
θ value	0.0736092 (rank : 111)	NC score	0.024005 (rank : 248)
Query Neighborhood Hits	260	Target Neighborhood Hits	1384	Shared Neighborhood Hits	45
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

SWP70_HUMAN
θ value	0.0736092 (rank : 112)	NC score	0.075815 (rank : 133)
Query Neighborhood Hits	260	Target Neighborhood Hits	973	Shared Neighborhood Hits	84
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

EPHA4_MOUSE
θ value	0.0961366 (rank : 113)	NC score	0.040588 (rank : 222)
Query Neighborhood Hits	260	Target Neighborhood Hits	982	Shared Neighborhood Hits	41
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHB6_MOUSE
θ value	0.0961366 (rank : 114)	NC score	0.046812 (rank : 216)
Query Neighborhood Hits	260	Target Neighborhood Hits	906	Shared Neighborhood Hits	39
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

PKHA5_HUMAN
θ value	0.0961366 (rank : 115)	NC score	0.126935 (rank : 104)
Query Neighborhood Hits	260	Target Neighborhood Hits	455	Shared Neighborhood Hits	74
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

RAPH1_HUMAN
θ value	0.0961366 (rank : 116)	NC score	0.062952 (rank : 157)
Query Neighborhood Hits	260	Target Neighborhood Hits	593	Shared Neighborhood Hits	27
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

EPHA2_HUMAN
θ value	0.125558 (rank : 117)	NC score	0.037123 (rank : 229)
Query Neighborhood Hits	260	Target Neighborhood Hits	1021	Shared Neighborhood Hits	41
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHA2_MOUSE
θ value	0.125558 (rank : 118)	NC score	0.037590 (rank : 226)
Query Neighborhood Hits	260	Target Neighborhood Hits	1020	Shared Neighborhood Hits	41
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

GAB2_MOUSE
θ value	0.125558 (rank : 119)	NC score	0.110243 (rank : 107)
Query Neighborhood Hits	260	Target Neighborhood Hits	220	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

PKHA4_MOUSE
θ value	0.125558 (rank : 120)	NC score	0.138394 (rank : 102)
Query Neighborhood Hits	260	Target Neighborhood Hits	202	Shared Neighborhood Hits	49
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

CLCN1_HUMAN
θ value	0.163984 (rank : 121)	NC score	0.023890 (rank : 249)
Query Neighborhood Hits	260	Target Neighborhood Hits	89	Shared Neighborhood Hits	6
SwissProt Accessions	P35523	Gene names	CLCN1, CLC1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

MRIP_HUMAN
θ value	0.163984 (rank : 122)	NC score	0.068536 (rank : 148)
Query Neighborhood Hits	260	Target Neighborhood Hits	578	Shared Neighborhood Hits	65
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

PKHA3_HUMAN
θ value	0.163984 (rank : 123)	NC score	0.092790 (rank : 114)
Query Neighborhood Hits	260	Target Neighborhood Hits	66	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

TNKS1_HUMAN
θ value	0.163984 (rank : 124)	NC score	0.076027 (rank : 131)
Query Neighborhood Hits	260	Target Neighborhood Hits	477	Shared Neighborhood Hits	45
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

EPHA6_MOUSE
θ value	0.21417 (rank : 125)	NC score	0.040444 (rank : 223)
Query Neighborhood Hits	260	Target Neighborhood Hits	946	Shared Neighborhood Hits	40
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

FARP1_HUMAN
θ value	0.21417 (rank : 126)	NC score	0.057721 (rank : 171)
Query Neighborhood Hits	260	Target Neighborhood Hits	241	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

PKHA3_MOUSE
θ value	0.21417 (rank : 127)	NC score	0.092363 (rank : 115)
Query Neighborhood Hits	260	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

RASA2_HUMAN
θ value	0.21417 (rank : 128)	NC score	0.071364 (rank : 139)
Query Neighborhood Hits	260	Target Neighborhood Hits	157	Shared Neighborhood Hits	34
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

EPHB1_HUMAN
θ value	0.279714 (rank : 129)	NC score	0.036288 (rank : 233)
Query Neighborhood Hits	260	Target Neighborhood Hits	988	Shared Neighborhood Hits	40
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

PPR3A_HUMAN
θ value	0.279714 (rank : 130)	NC score	0.025849 (rank : 245)
Query Neighborhood Hits	260	Target Neighborhood Hits	54	Shared Neighborhood Hits	2
SwissProt Accessions	Q16821, O43476, Q75LN8, Q7KYM8, Q86UI6	Gene names	PPP1R3A, PP1G
Domain Architecture	No domain graphic available
Description	Protein phosphatase 1 regulatory subunit 3A (Protein phosphatase 1 glycogen-associated regulatory subunit) (Protein phosphatase type-1 glycogen targeting subunit).

SASH1_MOUSE
θ value	0.279714 (rank : 131)	NC score	0.062572 (rank : 159)
Query Neighborhood Hits	260	Target Neighborhood Hits	263	Shared Neighborhood Hits	39
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

TNKS2_HUMAN
θ value	0.279714 (rank : 132)	NC score	0.069651 (rank : 146)
Query Neighborhood Hits	260	Target Neighborhood Hits	361	Shared Neighborhood Hits	35
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

NIN_HUMAN
θ value	0.365318 (rank : 133)	NC score	0.023276 (rank : 250)
Query Neighborhood Hits	260	Target Neighborhood Hits	1416	Shared Neighborhood Hits	50
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

PKHA4_HUMAN
θ value	0.365318 (rank : 134)	NC score	0.128178 (rank : 103)
Query Neighborhood Hits	260	Target Neighborhood Hits	283	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

EPHA6_HUMAN
θ value	0.47712 (rank : 135)	NC score	0.041687 (rank : 221)
Query Neighborhood Hits	260	Target Neighborhood Hits	959	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

XPO7_HUMAN
θ value	0.47712 (rank : 136)	NC score	0.027249 (rank : 244)
Query Neighborhood Hits	260	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UIA9, O94846, Q6PJK9, Q8NEK7	Gene names	XPO7, KIAA0745, RANBP16
Domain Architecture
Description	Exportin-7 (Exp7) (Ran-binding protein 16).

XPO7_MOUSE
θ value	0.47712 (rank : 137)	NC score	0.027278 (rank : 243)
Query Neighborhood Hits	260	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EPK7, Q3TP94, Q80TS9, Q8BSK5, Q8C9M7, Q8CB42, Q8CBL8, Q8CEF5	Gene names	Xpo7, Kiaa0745, Ranbp16
Domain Architecture
Description	Exportin-7 (Exp7) (Ran-binding protein 16).

OSBL9_HUMAN
θ value	0.62314 (rank : 138)	NC score	0.070829 (rank : 141)
Query Neighborhood Hits	260	Target Neighborhood Hits	138	Shared Neighborhood Hits	45
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

PKHA2_HUMAN
θ value	0.62314 (rank : 139)	NC score	0.175196 (rank : 99)
Query Neighborhood Hits	260	Target Neighborhood Hits	119	Shared Neighborhood Hits	60
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

CSKI2_HUMAN
θ value	0.813845 (rank : 140)	NC score	0.080358 (rank : 124)
Query Neighborhood Hits	260	Target Neighborhood Hits	747	Shared Neighborhood Hits	65
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CSKI2_MOUSE
θ value	0.813845 (rank : 141)	NC score	0.081867 (rank : 121)
Query Neighborhood Hits	260	Target Neighborhood Hits	812	Shared Neighborhood Hits	70
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CYH1_MOUSE
θ value	0.813845 (rank : 142)	NC score	0.077407 (rank : 126)
Query Neighborhood Hits	260	Target Neighborhood Hits	176	Shared Neighborhood Hits	57
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

DESP_HUMAN
θ value	0.813845 (rank : 143)	NC score	0.018435 (rank : 266)
Query Neighborhood Hits	260	Target Neighborhood Hits	1470	Shared Neighborhood Hits	49
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

DGKD_HUMAN
θ value	0.813845 (rank : 144)	NC score	0.103513 (rank : 110)
Query Neighborhood Hits	260	Target Neighborhood Hits	231	Shared Neighborhood Hits	62
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

DPOG1_MOUSE
θ value	0.813845 (rank : 145)	NC score	0.020866 (rank : 258)
Query Neighborhood Hits	260	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	P54099, Q9JI28	Gene names	Polg, Polg1
Domain Architecture
Description	DNA polymerase subunit gamma 1 (EC 2.7.7.7) (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha).

FGD6_HUMAN
θ value	0.813845 (rank : 146)	NC score	0.053073 (rank : 187)
Query Neighborhood Hits	260	Target Neighborhood Hits	237	Shared Neighborhood Hits	45
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

PKHB1_MOUSE
θ value	0.813845 (rank : 147)	NC score	0.053176 (rank : 186)
Query Neighborhood Hits	260	Target Neighborhood Hits	47	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

RAI14_HUMAN
θ value	0.813845 (rank : 148)	NC score	0.060441 (rank : 166)
Query Neighborhood Hits	260	Target Neighborhood Hits	1367	Shared Neighborhood Hits	70
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

EPHA8_HUMAN
θ value	1.06291 (rank : 149)	NC score	0.037325 (rank : 227)
Query Neighborhood Hits	260	Target Neighborhood Hits	956	Shared Neighborhood Hits	40
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHA8_MOUSE
θ value	1.06291 (rank : 150)	NC score	0.038881 (rank : 225)
Query Neighborhood Hits	260	Target Neighborhood Hits	969	Shared Neighborhood Hits	40
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

FGD6_MOUSE
θ value	1.06291 (rank : 151)	NC score	0.048819 (rank : 213)
Query Neighborhood Hits	260	Target Neighborhood Hits	282	Shared Neighborhood Hits	37
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

RASA3_MOUSE
θ value	1.06291 (rank : 152)	NC score	0.071146 (rank : 140)
Query Neighborhood Hits	260	Target Neighborhood Hits	144	Shared Neighborhood Hits	36
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

RBCC1_MOUSE
θ value	1.06291 (rank : 153)	NC score	0.016337 (rank : 272)
Query Neighborhood Hits	260	Target Neighborhood Hits	1048	Shared Neighborhood Hits	40
SwissProt Accessions	Q9ESK9, Q3TXX2, Q61384, Q8BRY9, Q9JK14	Gene names	Rb1cc1, Cc1, Kiaa0203
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (LaXp180 protein).

SKI_HUMAN
θ value	1.06291 (rank : 154)	NC score	0.018385 (rank : 267)
Query Neighborhood Hits	260	Target Neighborhood Hits	423	Shared Neighborhood Hits	23
SwissProt Accessions	P12755, Q5SYT7	Gene names	SKI
Domain Architecture
Description	Ski oncogene (C-ski).

TRHY_HUMAN
θ value	1.06291 (rank : 155)	NC score	0.013119 (rank : 285)
Query Neighborhood Hits	260	Target Neighborhood Hits	1385	Shared Neighborhood Hits	40
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

C43BP_MOUSE
θ value	1.38821 (rank : 156)	NC score	0.081210 (rank : 123)
Query Neighborhood Hits	260	Target Neighborhood Hits	91	Shared Neighborhood Hits	40
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

CENPE_HUMAN
θ value	1.38821 (rank : 157)	NC score	0.019431 (rank : 262)
Query Neighborhood Hits	260	Target Neighborhood Hits	2060	Shared Neighborhood Hits	64
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

CIR_HUMAN
θ value	1.38821 (rank : 158)	NC score	0.018560 (rank : 263)
Query Neighborhood Hits	260	Target Neighborhood Hits	249	Shared Neighborhood Hits	12
SwissProt Accessions	Q86X95, O95367, Q12804, Q4G1B9, Q6PJI4, Q8IWI2	Gene names	CIR
Domain Architecture	No domain graphic available
Description	CBF1-interacting corepressor (Recepin).

EPHA7_HUMAN
θ value	1.38821 (rank : 159)	NC score	0.036526 (rank : 231)
Query Neighborhood Hits	260	Target Neighborhood Hits	1053	Shared Neighborhood Hits	40
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA7_MOUSE
θ value	1.38821 (rank : 160)	NC score	0.035977 (rank : 234)
Query Neighborhood Hits	260	Target Neighborhood Hits	1025	Shared Neighborhood Hits	39
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHB2_HUMAN
θ value	1.38821 (rank : 161)	NC score	0.035848 (rank : 235)
Query Neighborhood Hits	260	Target Neighborhood Hits	983	Shared Neighborhood Hits	39
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

FGD4_HUMAN
θ value	1.38821 (rank : 162)	NC score	0.049601 (rank : 210)
Query Neighborhood Hits	260	Target Neighborhood Hits	219	Shared Neighborhood Hits	45
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

MADCA_MOUSE
θ value	1.38821 (rank : 163)	NC score	0.021519 (rank : 255)
Query Neighborhood Hits	260	Target Neighborhood Hits	56	Shared Neighborhood Hits	4
SwissProt Accessions	Q61826, O35530, Q61278, Q64275, Q8R1M6	Gene names	Madcam1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (mMAdCAM-1).

SASH1_HUMAN
θ value	1.38821 (rank : 164)	NC score	0.062144 (rank : 162)
Query Neighborhood Hits	260	Target Neighborhood Hits	292	Shared Neighborhood Hits	36
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

GAB1_HUMAN
θ value	1.81305 (rank : 165)	NC score	0.087852 (rank : 118)
Query Neighborhood Hits	260	Target Neighborhood Hits	279	Shared Neighborhood Hits	37
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

KTN1_HUMAN
θ value	1.81305 (rank : 166)	NC score	0.016064 (rank : 273)
Query Neighborhood Hits	260	Target Neighborhood Hits	1197	Shared Neighborhood Hits	43
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

OSBP2_HUMAN
θ value	1.81305 (rank : 167)	NC score	0.055318 (rank : 178)
Query Neighborhood Hits	260	Target Neighborhood Hits	154	Shared Neighborhood Hits	41
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

PAPOG_MOUSE
θ value	1.81305 (rank : 168)	NC score	0.013921 (rank : 282)
Query Neighborhood Hits	260	Target Neighborhood Hits	103	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PCL9, Q8BZC9	Gene names	Papolg
Domain Architecture	No domain graphic available
Description	Poly(A) polymerase gamma (EC 2.7.7.19) (PAP gamma) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3' adenylating enzyme).

PKHB1_HUMAN
θ value	1.81305 (rank : 169)	NC score	0.047742 (rank : 214)
Query Neighborhood Hits	260	Target Neighborhood Hits	46	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

SAMN1_HUMAN
θ value	1.81305 (rank : 170)	NC score	0.039726 (rank : 224)
Query Neighborhood Hits	260	Target Neighborhood Hits	74	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

STAP2_MOUSE
θ value	1.81305 (rank : 171)	NC score	0.036789 (rank : 230)
Query Neighborhood Hits	260	Target Neighborhood Hits	41	Shared Neighborhood Hits	8
SwissProt Accessions	Q8R0L1, Q8BWS2	Gene names	Stap2
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 2 (STAP-2).

ATS12_HUMAN
θ value	2.36792 (rank : 172)	NC score	0.001497 (rank : 320)
Query Neighborhood Hits	260	Target Neighborhood Hits	251	Shared Neighborhood Hits	4
SwissProt Accessions	P58397, Q6UWL3	Gene names	ADAMTS12
Domain Architecture
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

C43BP_HUMAN
θ value	2.36792 (rank : 173)	NC score	0.076656 (rank : 129)
Query Neighborhood Hits	260	Target Neighborhood Hits	87	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

CNOT2_MOUSE
θ value	2.36792 (rank : 174)	NC score	0.020783 (rank : 259)
Query Neighborhood Hits	260	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C5L3, Q3UE39, Q80YA5, Q9D0P1	Gene names	Cnot2
Domain Architecture
Description	CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2).

CYH1_HUMAN
θ value	2.36792 (rank : 175)	NC score	0.076039 (rank : 130)
Query Neighborhood Hits	260	Target Neighborhood Hits	184	Shared Neighborhood Hits	60
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

PAPOG_HUMAN
θ value	2.36792 (rank : 176)	NC score	0.013935 (rank : 281)
Query Neighborhood Hits	260	Target Neighborhood Hits	44	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BWT3, Q969N1, Q9H8L2, Q9HAD0	Gene names	PAPOLG, PAP2, PAPG
Domain Architecture
Description	Poly(A) polymerase gamma (EC 2.7.7.19) (PAP gamma) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3' adenylating enzyme) (Neo- poly(A) polymerase) (Neo-PAP).

RFC1_HUMAN
θ value	2.36792 (rank : 177)	NC score	0.011072 (rank : 291)
Query Neighborhood Hits	260	Target Neighborhood Hits	352	Shared Neighborhood Hits	10
SwissProt Accessions	P35251, Q5XKF5, Q6PKU0, Q86V41, Q86V46	Gene names	RFC1, RFC140
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (DNA-binding protein PO-GA).

SOS1_MOUSE
θ value	2.36792 (rank : 178)	NC score	0.018460 (rank : 265)
Query Neighborhood Hits	260	Target Neighborhood Hits	281	Shared Neighborhood Hits	15
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS2_HUMAN
θ value	2.36792 (rank : 179)	NC score	0.021641 (rank : 253)
Query Neighborhood Hits	260	Target Neighborhood Hits	193	Shared Neighborhood Hits	14
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SVIL_MOUSE
θ value	2.36792 (rank : 180)	NC score	0.014723 (rank : 277)
Query Neighborhood Hits	260	Target Neighborhood Hits	439	Shared Neighborhood Hits	23
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

TEC_MOUSE
θ value	2.36792 (rank : 181)	NC score	0.024005 (rank : 247)
Query Neighborhood Hits	260	Target Neighborhood Hits	1006	Shared Neighborhood Hits	57
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ANLN_MOUSE
θ value	3.0926 (rank : 182)	NC score	0.037182 (rank : 228)
Query Neighborhood Hits	260	Target Neighborhood Hits	297	Shared Neighborhood Hits	28
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

CNOT2_HUMAN
θ value	3.0926 (rank : 183)	NC score	0.019668 (rank : 261)
Query Neighborhood Hits	260	Target Neighborhood Hits	51	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZN8, Q9H3E0, Q9NSX5, Q9NWR6, Q9P028	Gene names	CNOT2, CDC36, NOT2
Domain Architecture
Description	CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2).

FARP2_HUMAN
θ value	3.0926 (rank : 184)	NC score	0.048986 (rank : 212)
Query Neighborhood Hits	260	Target Neighborhood Hits	240	Shared Neighborhood Hits	39
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
θ value	3.0926 (rank : 185)	NC score	0.045184 (rank : 217)
Query Neighborhood Hits	260	Target Neighborhood Hits	209	Shared Neighborhood Hits	42
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FBX4_MOUSE
θ value	3.0926 (rank : 186)	NC score	0.013867 (rank : 283)
Query Neighborhood Hits	260	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CHQ0, Q99JG8	Gene names	Fbxo4, Fbx4
Domain Architecture	No domain graphic available
Description	F-box only protein 4.

IL9R_MOUSE
θ value	3.0926 (rank : 187)	NC score	0.012991 (rank : 286)
Query Neighborhood Hits	260	Target Neighborhood Hits	38	Shared Neighborhood Hits	2
SwissProt Accessions	Q01114	Gene names	Il9r
Domain Architecture	No domain graphic available
Description	Interleukin-9 receptor precursor (IL-9R) (CD129 antigen).

K1688_HUMAN
θ value	3.0926 (rank : 188)	NC score	0.258955 (rank : 93)
Query Neighborhood Hits	260	Target Neighborhood Hits	217	Shared Neighborhood Hits	58
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

OPRM_HUMAN
θ value	3.0926 (rank : 189)	NC score	-0.006579 (rank : 324)
Query Neighborhood Hits	260	Target Neighborhood Hits	900	Shared Neighborhood Hits	2
SwissProt Accessions	P35372, Q12930, Q7Z2D8, Q9UCZ4, Q9UN57	Gene names	OPRM1, MOR1
Domain Architecture
Description	Mu-type opioid receptor (MOR-1).

OSTP_HUMAN
θ value	3.0926 (rank : 190)	NC score	0.017459 (rank : 268)
Query Neighborhood Hits	260	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	P10451, Q15681, Q15682, Q15683, Q8NBK2, Q96IZ1	Gene names	SPP1, OPN
Domain Architecture
Description	Osteopontin precursor (Bone sialoprotein-1) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Nephropontin) (Uropontin).

OXR1_MOUSE
θ value	3.0926 (rank : 191)	NC score	0.008275 (rank : 299)
Query Neighborhood Hits	260	Target Neighborhood Hits	516	Shared Neighborhood Hits	15
SwissProt Accessions	Q4KMM3, Q5FWW1, Q99L06, Q99MK1, Q99MP4	Gene names	Oxr1, C7
Domain Architecture	No domain graphic available
Description	Oxidation resistance protein 1 (Protein C7).

RB39B_HUMAN
θ value	3.0926 (rank : 192)	NC score	0.016604 (rank : 270)
Query Neighborhood Hits	260	Target Neighborhood Hits	279	Shared Neighborhood Hits	15
SwissProt Accessions	Q96DA2, Q5JT79, Q8NEX3	Gene names	RAB39B
Domain Architecture
Description	Ras-related protein Rab-39B.

RB39B_MOUSE
θ value	3.0926 (rank : 193)	NC score	0.016629 (rank : 269)
Query Neighborhood Hits	260	Target Neighborhood Hits	277	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BHC1, Q3TUJ3	Gene names	Rab39b
Domain Architecture
Description	Ras-related protein Rab-39B.

SOS1_HUMAN
θ value	3.0926 (rank : 194)	NC score	0.022266 (rank : 251)
Query Neighborhood Hits	260	Target Neighborhood Hits	274	Shared Neighborhood Hits	16
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

ANKS1_MOUSE
θ value	4.03905 (rank : 195)	NC score	0.049770 (rank : 209)
Query Neighborhood Hits	260	Target Neighborhood Hits	453	Shared Neighborhood Hits	57
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

AP3B1_HUMAN
θ value	4.03905 (rank : 196)	NC score	0.005913 (rank : 311)
Query Neighborhood Hits	260	Target Neighborhood Hits	283	Shared Neighborhood Hits	8
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

ELL_MOUSE
θ value	4.03905 (rank : 197)	NC score	0.011275 (rank : 289)
Query Neighborhood Hits	260	Target Neighborhood Hits	115	Shared Neighborhood Hits	6
SwissProt Accessions	O08856	Gene names	Ell
Domain Architecture
Description	RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein).

EPHB2_MOUSE
θ value	4.03905 (rank : 198)	NC score	0.035277 (rank : 236)
Query Neighborhood Hits	260	Target Neighborhood Hits	982	Shared Neighborhood Hits	39
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

GAB1_MOUSE
θ value	4.03905 (rank : 199)	NC score	0.081704 (rank : 122)
Query Neighborhood Hits	260	Target Neighborhood Hits	233	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GCC2_HUMAN
θ value	4.03905 (rank : 200)	NC score	0.021545 (rank : 254)
Query Neighborhood Hits	260	Target Neighborhood Hits	1558	Shared Neighborhood Hits	58
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

OCRL_HUMAN
θ value	4.03905 (rank : 201)	NC score	0.166663 (rank : 100)
Query Neighborhood Hits	260	Target Neighborhood Hits	77	Shared Neighborhood Hits	49
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).

PKHF2_MOUSE
θ value	4.03905 (rank : 202)	NC score	0.030277 (rank : 240)
Query Neighborhood Hits	260	Target Neighborhood Hits	77	Shared Neighborhood Hits	18
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

RBP24_HUMAN
θ value	4.03905 (rank : 203)	NC score	0.021398 (rank : 257)
Query Neighborhood Hits	260	Target Neighborhood Hits	1559	Shared Neighborhood Hits	57
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

RPGR1_MOUSE
θ value	4.03905 (rank : 204)	NC score	0.018557 (rank : 264)
Query Neighborhood Hits	260	Target Neighborhood Hits	713	Shared Neighborhood Hits	32
SwissProt Accessions	Q9EPQ2, Q8CAC2, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1	Gene names	Rpgrip1
Domain Architecture	No domain graphic available
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

SKI_MOUSE
θ value	4.03905 (rank : 205)	NC score	0.014753 (rank : 276)
Query Neighborhood Hits	260	Target Neighborhood Hits	423	Shared Neighborhood Hits	20
SwissProt Accessions	Q60698, Q8VIL5	Gene names	Ski
Domain Architecture	No domain graphic available
Description	Ski oncogene (C-ski).

SLK_HUMAN
θ value	4.03905 (rank : 206)	NC score	0.007042 (rank : 307)
Query Neighborhood Hits	260	Target Neighborhood Hits	1775	Shared Neighborhood Hits	66
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

SLK_MOUSE
θ value	4.03905 (rank : 207)	NC score	0.007752 (rank : 301)
Query Neighborhood Hits	260	Target Neighborhood Hits	1798	Shared Neighborhood Hits	66
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

TSH3_HUMAN
θ value	4.03905 (rank : 208)	NC score	0.004302 (rank : 314)
Query Neighborhood Hits	260	Target Neighborhood Hits	564	Shared Neighborhood Hits	4
SwissProt Accessions	Q63HK5, Q9H0G6, Q9P254	Gene names	TSHZ3, KIAA1474, TSH3, ZNF537
Domain Architecture	No domain graphic available
Description	Teashirt homolog 3 (Zinc finger protein 537).

ULK2_HUMAN
θ value	4.03905 (rank : 209)	NC score	0.003910 (rank : 315)
Query Neighborhood Hits	260	Target Neighborhood Hits	979	Shared Neighborhood Hits	30
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

ZC313_HUMAN
θ value	4.03905 (rank : 210)	NC score	0.011263 (rank : 290)
Query Neighborhood Hits	260	Target Neighborhood Hits	772	Shared Neighborhood Hits	22
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

CLCN1_MOUSE
θ value	5.27518 (rank : 211)	NC score	0.014286 (rank : 279)
Query Neighborhood Hits	260	Target Neighborhood Hits	61	Shared Neighborhood Hits	4
SwissProt Accessions	Q64347	Gene names	Clcn1, Clc1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

CSKI1_MOUSE
θ value	5.27518 (rank : 212)	NC score	0.069681 (rank : 145)
Query Neighborhood Hits	260	Target Neighborhood Hits	1031	Shared Neighborhood Hits	62
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

EPHA5_HUMAN
θ value	5.27518 (rank : 213)	NC score	0.036366 (rank : 232)
Query Neighborhood Hits	260	Target Neighborhood Hits	1009	Shared Neighborhood Hits	42
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHB4_MOUSE
θ value	5.27518 (rank : 214)	NC score	0.032395 (rank : 237)
Query Neighborhood Hits	260	Target Neighborhood Hits	1013	Shared Neighborhood Hits	40
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

KIF1B_HUMAN
θ value	5.27518 (rank : 215)	NC score	0.009136 (rank : 295)
Query Neighborhood Hits	260	Target Neighborhood Hits	178	Shared Neighborhood Hits	19
SwissProt Accessions	O60333, Q96Q94, Q9BV80, Q9P280	Gene names	KIF1B, KIAA0591, KIAA1448
Domain Architecture
Description	Kinesin-like protein KIF1B (Klp).

KIF3B_HUMAN
θ value	5.27518 (rank : 216)	NC score	0.006031 (rank : 310)
Query Neighborhood Hits	260	Target Neighborhood Hits	540	Shared Neighborhood Hits	28
SwissProt Accessions	O15066	Gene names	KIF3B, KIAA0359
Domain Architecture
Description	Kinesin-like protein KIF3B (Microtubule plus end-directed kinesin motor 3B) (HH0048).

PKHF2_HUMAN
θ value	5.27518 (rank : 217)	NC score	0.029694 (rank : 241)
Query Neighborhood Hits	260	Target Neighborhood Hits	75	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

RB39A_HUMAN
θ value	5.27518 (rank : 218)	NC score	0.012022 (rank : 288)
Query Neighborhood Hits	260	Target Neighborhood Hits	276	Shared Neighborhood Hits	15
SwissProt Accessions	Q14964, Q8N6W2	Gene names	RAB39, RAB39A
Domain Architecture
Description	Ras-related protein Rab-39A (Rab-39).

STAP2_HUMAN
θ value	5.27518 (rank : 219)	NC score	0.021513 (rank : 256)
Query Neighborhood Hits	260	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UGK3, Q9NXI2	Gene names	STAP2, BKS
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 2 (STAP-2) (Breast tumor kinase substrate) (BRK substrate).

SYTL4_HUMAN
θ value	5.27518 (rank : 220)	NC score	0.007190 (rank : 306)
Query Neighborhood Hits	260	Target Neighborhood Hits	138	Shared Neighborhood Hits	9
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

ACINU_HUMAN
θ value	6.88961 (rank : 221)	NC score	0.006731 (rank : 309)
Query Neighborhood Hits	260	Target Neighborhood Hits	828	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

BBX_MOUSE
θ value	6.88961 (rank : 222)	NC score	0.003660 (rank : 316)
Query Neighborhood Hits	260	Target Neighborhood Hits	152	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VBW5, Q3TZK1, Q6NXY8, Q6PEU3, Q8BQJ7, Q8C7E0, Q8CDQ0, Q8CDV1, Q8VI48, Q8VI49, Q8VI50, Q9CS94	Gene names	Bbx, Hbp2
Domain Architecture	No domain graphic available
Description	HMG box transcription factor BBX (Bobby sox homolog) (HMG box- containing protein 2).

CENPU_MOUSE
θ value	6.88961 (rank : 223)	NC score	0.014041 (rank : 280)
Query Neighborhood Hits	260	Target Neighborhood Hits	137	Shared Neighborhood Hits	10
SwissProt Accessions	Q8C4M7, Q6UNA2, Q9D9U1	Gene names	Mlf1ip, Cenpu
Domain Architecture	No domain graphic available
Description	Centromere protein U (CENP-U) (MLF1-interacting protein).

CHD2_HUMAN
θ value	6.88961 (rank : 224)	NC score	0.005567 (rank : 312)
Query Neighborhood Hits	260	Target Neighborhood Hits	360	Shared Neighborhood Hits	14
SwissProt Accessions	O14647	Gene names	CHD2
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 2 (EC 3.6.1.-) (ATP- dependent helicase CHD2) (CHD-2).

CSKI1_HUMAN
θ value	6.88961 (rank : 225)	NC score	0.071942 (rank : 138)
Query Neighborhood Hits	260	Target Neighborhood Hits	997	Shared Neighborhood Hits	67
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CYH2_HUMAN
θ value	6.88961 (rank : 226)	NC score	0.070617 (rank : 142)
Query Neighborhood Hits	260	Target Neighborhood Hits	175	Shared Neighborhood Hits	57
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	6.88961 (rank : 227)	NC score	0.070312 (rank : 144)
Query Neighborhood Hits	260	Target Neighborhood Hits	171	Shared Neighborhood Hits	56
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

DOK4_HUMAN
θ value	6.88961 (rank : 228)	NC score	0.008809 (rank : 297)
Query Neighborhood Hits	260	Target Neighborhood Hits	28	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TEW6, O75209, Q9BTP2, Q9NVV3	Gene names	DOK4
Domain Architecture	No domain graphic available
Description	Docking protein 4 (Downstream of tyrosine kinase 4).

DOK4_MOUSE
θ value	6.88961 (rank : 229)	NC score	0.008818 (rank : 296)
Query Neighborhood Hits	260	Target Neighborhood Hits	30	Shared Neighborhood Hits	5
SwissProt Accessions	Q99KE3, Q3U0X3	Gene names	Dok4
Domain Architecture	No domain graphic available
Description	Docking protein 4 (Downstream of tyrosine kinase 4).

DYH11_HUMAN
θ value	6.88961 (rank : 230)	NC score	0.006950 (rank : 308)
Query Neighborhood Hits	260	Target Neighborhood Hits	234	Shared Neighborhood Hits	15
SwissProt Accessions	Q96DT5, Q9UJ82	Gene names	DNAH11
Domain Architecture
Description	Ciliary dynein heavy chain 11 (Axonemal beta dynein heavy chain 11).

EPHB4_HUMAN
θ value	6.88961 (rank : 231)	NC score	0.031825 (rank : 238)
Query Neighborhood Hits	260	Target Neighborhood Hits	1056	Shared Neighborhood Hits	40
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

GOGA5_HUMAN
θ value	6.88961 (rank : 232)	NC score	0.015998 (rank : 274)
Query Neighborhood Hits	260	Target Neighborhood Hits	1168	Shared Neighborhood Hits	51
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

INSRR_MOUSE
θ value	6.88961 (rank : 233)	NC score	0.014660 (rank : 278)
Query Neighborhood Hits	260	Target Neighborhood Hits	961	Shared Neighborhood Hits	27
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

K1688_MOUSE
θ value	6.88961 (rank : 234)	NC score	0.266322 (rank : 92)
Query Neighborhood Hits	260	Target Neighborhood Hits	188	Shared Neighborhood Hits	60
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

MACF4_HUMAN
θ value	6.88961 (rank : 235)	NC score	0.009478 (rank : 294)
Query Neighborhood Hits	260	Target Neighborhood Hits	1321	Shared Neighborhood Hits	43
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

MUT_MOUSE
θ value	6.88961 (rank : 236)	NC score	0.012130 (rank : 287)
Query Neighborhood Hits	260	Target Neighborhood Hits	52	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R015, Q3TCP2, Q8CAC9	Gene names	Muted, Mu
Domain Architecture	No domain graphic available
Description	Muted protein.

RAB8A_HUMAN
θ value	6.88961 (rank : 237)	NC score	0.003232 (rank : 319)
Query Neighborhood Hits	260	Target Neighborhood Hits	269	Shared Neighborhood Hits	9
SwissProt Accessions	P61006, P24407	Gene names	RAB8A, MEL, RAB8
Domain Architecture
Description	Ras-related protein Rab-8A (Oncogene c-mel).

RAB8A_MOUSE
θ value	6.88961 (rank : 238)	NC score	0.003244 (rank : 318)
Query Neighborhood Hits	260	Target Neighborhood Hits	269	Shared Neighborhood Hits	9
SwissProt Accessions	P55258, Q8VCF6	Gene names	Rab8a, Mel, Rab8
Domain Architecture
Description	Ras-related protein Rab-8A (Oncogene c-mel).

RIF1_MOUSE
θ value	6.88961 (rank : 239)	NC score	0.009555 (rank : 293)
Query Neighborhood Hits	260	Target Neighborhood Hits	315	Shared Neighborhood Hits	15
SwissProt Accessions	Q6PR54, Q6T8D9, Q7TPD8, Q8BTU2, Q8C408, Q9CS77	Gene names	Rif1
Domain Architecture	No domain graphic available
Description	Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) (mRif1).

SAMN1_MOUSE
θ value	6.88961 (rank : 240)	NC score	0.031061 (rank : 239)
Query Neighborhood Hits	260	Target Neighborhood Hits	69	Shared Neighborhood Hits	14
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

ALS2_HUMAN
θ value	8.99809 (rank : 241)	NC score	0.016430 (rank : 271)
Query Neighborhood Hits	260	Target Neighborhood Hits	121	Shared Neighborhood Hits	20
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

ALS2_MOUSE
θ value	8.99809 (rank : 242)	NC score	0.015470 (rank : 275)
Query Neighborhood Hits	260	Target Neighborhood Hits	111	Shared Neighborhood Hits	16
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

AP3D1_MOUSE
θ value	8.99809 (rank : 243)	NC score	0.003390 (rank : 317)
Query Neighborhood Hits	260	Target Neighborhood Hits	144	Shared Neighborhood Hits	5
SwissProt Accessions	O54774	Gene names	Ap3d1, Ap3d
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin) (mBLVR1).

CI084_HUMAN
θ value	8.99809 (rank : 244)	NC score	0.020506 (rank : 260)
Query Neighborhood Hits	260	Target Neighborhood Hits	40	Shared Neighborhood Hits	5
SwissProt Accessions	Q5VXU9, Q96M73	Gene names	C9orf84
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf84.

DAPP1_MOUSE
θ value	8.99809 (rank : 245)	NC score	0.103671 (rank : 109)
Query Neighborhood Hits	260	Target Neighborhood Hits	225	Shared Neighborhood Hits	55
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DYNA_HUMAN
θ value	8.99809 (rank : 246)	NC score	0.008097 (rank : 300)
Query Neighborhood Hits	260	Target Neighborhood Hits	1194	Shared Neighborhood Hits	33
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

DYNA_MOUSE
θ value	8.99809 (rank : 247)	NC score	0.007488 (rank : 303)
Query Neighborhood Hits	260	Target Neighborhood Hits	1084	Shared Neighborhood Hits	32
SwissProt Accessions	O08788	Gene names	Dctn1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued).

FILA_HUMAN
θ value	8.99809 (rank : 248)	NC score	0.005565 (rank : 313)
Query Neighborhood Hits	260	Target Neighborhood Hits	685	Shared Neighborhood Hits	20
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

KIF1B_MOUSE
θ value	8.99809 (rank : 249)	NC score	0.008801 (rank : 298)
Query Neighborhood Hits	260	Target Neighborhood Hits	167	Shared Neighborhood Hits	17
SwissProt Accessions	Q60575, Q9R0B4, Q9WVE5, Q9Z119	Gene names	Kif1b
Domain Architecture
Description	Kinesin-like protein KIF1B.

LC7L2_HUMAN
θ value	8.99809 (rank : 250)	NC score	0.007432 (rank : 304)
Query Neighborhood Hits	260	Target Neighborhood Hits	235	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y383, Q8IUP9, Q9NVL3, Q9NVN7, Q9UQN1	Gene names	LUC7L2
Domain Architecture
Description	Putative RNA-binding protein Luc7-like 2.

LC7L2_MOUSE
θ value	8.99809 (rank : 251)	NC score	0.007722 (rank : 302)
Query Neighborhood Hits	260	Target Neighborhood Hits	244	Shared Neighborhood Hits	16
SwissProt Accessions	Q7TNC4, Q99LM5, Q99PC3	Gene names	Luc7l2
Domain Architecture
Description	Putative RNA-binding protein Luc7-like 2 (CGI-74 homolog).

MASTL_HUMAN
θ value	8.99809 (rank : 252)	NC score	-0.000553 (rank : 323)
Query Neighborhood Hits	260	Target Neighborhood Hits	894	Shared Neighborhood Hits	26
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

METL4_HUMAN
θ value	8.99809 (rank : 253)	NC score	0.007322 (rank : 305)
Query Neighborhood Hits	260	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N3J2, Q2TAA7, Q9H5U9	Gene names	METTL4
Domain Architecture	No domain graphic available
Description	Methyltransferase-like protein 4 (EC 2.1.1.-).

OSBP1_HUMAN
θ value	8.99809 (rank : 254)	NC score	0.072092 (rank : 137)
Query Neighborhood Hits	260	Target Neighborhood Hits	180	Shared Neighborhood Hits	52
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

OSBP2_MOUSE
θ value	8.99809 (rank : 255)	NC score	0.048995 (rank : 211)
Query Neighborhood Hits	260	Target Neighborhood Hits	150	Shared Neighborhood Hits	43
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

PKHF1_MOUSE
θ value	8.99809 (rank : 256)	NC score	0.029061 (rank : 242)
Query Neighborhood Hits	260	Target Neighborhood Hits	80	Shared Neighborhood Hits	18
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

RB39A_MOUSE
θ value	8.99809 (rank : 257)	NC score	0.010388 (rank : 292)
Query Neighborhood Hits	260	Target Neighborhood Hits	279	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BHD0	Gene names	Rab39, Rab39a
Domain Architecture
Description	Ras-related protein Rab-39A (Rab-39).

RBBP7_HUMAN
θ value	8.99809 (rank : 258)	NC score	-0.000312 (rank : 321)
Query Neighborhood Hits	260	Target Neighborhood Hits	285	Shared Neighborhood Hits	3
SwissProt Accessions	Q16576	Gene names	RBBP7, RBAP46
Domain Architecture
Description	Histone-binding protein RBBP7 (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) (Histone acetyltransferase type B subunit 2) (Nucleosome remodeling factor subunit RBAP46).

RBBP7_MOUSE
θ value	8.99809 (rank : 259)	NC score	-0.000318 (rank : 322)
Query Neighborhood Hits	260	Target Neighborhood Hits	285	Shared Neighborhood Hits	3
SwissProt Accessions	Q60973, Q3UX20	Gene names	Rbbp7, Rbap46
Domain Architecture
Description	Histone-binding protein RBBP7 (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) (Histone acetyltransferase type B subunit 2) (Nucleosome remodeling factor subunit RBAP46).

SPC25_MOUSE
θ value	8.99809 (rank : 260)	NC score	0.013755 (rank : 284)
Query Neighborhood Hits	260	Target Neighborhood Hits	241	Shared Neighborhood Hits	19
SwissProt Accessions	Q3UA16, Q9D021, Q9D1K6	Gene names	Spbc25
Domain Architecture	No domain graphic available
Description	Kinetochore protein Spc25.

3BP2_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.064506 (rank : 153)
Query Neighborhood Hits	260	Target Neighborhood Hits	296	Shared Neighborhood Hits	39
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

3BP2_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.054505 (rank : 181)
Query Neighborhood Hits	260	Target Neighborhood Hits	142	Shared Neighborhood Hits	34
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

ANK1_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.050858 (rank : 201)
Query Neighborhood Hits	260	Target Neighborhood Hits	416	Shared Neighborhood Hits	27
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

ANK1_MOUSE
θ value	θ > 10 (rank : 264)	NC score	0.050945 (rank : 200)
Query Neighborhood Hits	260	Target Neighborhood Hits	430	Shared Neighborhood Hits	30
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

ANKR2_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.053189 (rank : 185)
Query Neighborhood Hits	260	Target Neighborhood Hits	321	Shared Neighborhood Hits	26
SwissProt Accessions	Q9GZV1, Q5T456, Q8WUD7	Gene names	ANKRD2, ARPP
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp).

ANKR6_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.052361 (rank : 192)
Query Neighborhood Hits	260	Target Neighborhood Hits	439	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y2G4, Q9NU24, Q9UFQ9	Gene names	ANKRD6, KIAA0957
Domain Architecture
Description	Ankyrin repeat domain-containing protein 6.

ANR10_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.052994 (rank : 188)
Query Neighborhood Hits	260	Target Neighborhood Hits	289	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NXR5	Gene names	ANKRD10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

ANR10_MOUSE
θ value	θ > 10 (rank : 268)	NC score	0.050677 (rank : 203)
Query Neighborhood Hits	260	Target Neighborhood Hits	273	Shared Neighborhood Hits	26
SwissProt Accessions	Q99LW0	Gene names	Ankrd10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

ANR37_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.059700 (rank : 170)
Query Neighborhood Hits	260	Target Neighborhood Hits	247	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z713	Gene names	ANKRD37, LPR2BP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37 (Low-density lipoprotein receptor-related protein 2-binding protein) (hLrp2bp).

ANR37_MOUSE
θ value	θ > 10 (rank : 270)	NC score	0.069552 (rank : 147)
Query Neighborhood Hits	260	Target Neighborhood Hits	237	Shared Neighborhood Hits	24
SwissProt Accessions	Q569N2, Q8CHS0	Gene names	Ankrd37
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37.

ANR39_HUMAN
θ value	θ > 10 (rank : 271)	NC score	0.063824 (rank : 155)
Query Neighborhood Hits	260	Target Neighborhood Hits	285	Shared Neighborhood Hits	26
SwissProt Accessions	Q53RE8, Q59FU2, Q8N5X5, Q9P0S5	Gene names	ANKRD39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ANR39_MOUSE
θ value	θ > 10 (rank : 272)	NC score	0.065033 (rank : 152)
Query Neighborhood Hits	260	Target Neighborhood Hits	284	Shared Neighborhood Hits	26
SwissProt Accessions	Q9D2X0	Gene names	Ankrd39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ANR41_HUMAN
θ value	θ > 10 (rank : 273)	NC score	0.073012 (rank : 136)
Query Neighborhood Hits	260	Target Neighborhood Hits	332	Shared Neighborhood Hits	27
SwissProt Accessions	Q8NAG6, Q8N8J8	Gene names	ANKRD41
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 41.

ANR42_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.052034 (rank : 195)
Query Neighborhood Hits	260	Target Neighborhood Hits	284	Shared Neighborhood Hits	26
SwissProt Accessions	Q8N9B4, Q49A49	Gene names	ANKRD42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

ANR46_HUMAN
θ value	θ > 10 (rank : 275)	NC score	0.067976 (rank : 149)
Query Neighborhood Hits	260	Target Neighborhood Hits	281	Shared Neighborhood Hits	25
SwissProt Accessions	Q86W74, Q6P9B7	Gene names	ANKRD46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

ANR46_MOUSE
θ value	θ > 10 (rank : 276)	NC score	0.067462 (rank : 150)
Query Neighborhood Hits	260	Target Neighborhood Hits	274	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BTZ5, Q1LZK9, Q8BV97	Gene names	Ankrd46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

ANR52_HUMAN
θ value	θ > 10 (rank : 277)	NC score	0.050040 (rank : 207)
Query Neighborhood Hits	260	Target Neighborhood Hits	322	Shared Neighborhood Hits	26
SwissProt Accessions	Q8NB46	Gene names	ANKRD52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ANR52_MOUSE
θ value	θ > 10 (rank : 278)	NC score	0.050030 (rank : 208)
Query Neighborhood Hits	260	Target Neighborhood Hits	318	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BTI7	Gene names	Ankrd52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ANS4B_HUMAN
θ value	θ > 10 (rank : 279)	NC score	0.055591 (rank : 175)
Query Neighborhood Hits	260	Target Neighborhood Hits	289	Shared Neighborhood Hits	25
SwissProt Accessions	Q8N8V4	Gene names	ANKS4B, HARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

ANS4B_MOUSE
θ value	θ > 10 (rank : 280)	NC score	0.060664 (rank : 164)
Query Neighborhood Hits	260	Target Neighborhood Hits	294	Shared Neighborhood Hits	25
SwissProt Accessions	Q8K3X6, Q9D8A5	Gene names	Anks4b, Harp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

ASB10_HUMAN
θ value	θ > 10 (rank : 281)	NC score	0.052766 (rank : 190)
Query Neighborhood Hits	260	Target Neighborhood Hits	291	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WXI3	Gene names	ASB10
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

ASB10_MOUSE
θ value	θ > 10 (rank : 282)	NC score	0.050547 (rank : 205)
Query Neighborhood Hits	260	Target Neighborhood Hits	301	Shared Neighborhood Hits	26
SwissProt Accessions	Q91ZT7	Gene names	Asb10
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

CDN2D_HUMAN
θ value	θ > 10 (rank : 283)	NC score	0.054770 (rank : 180)
Query Neighborhood Hits	260	Target Neighborhood Hits	268	Shared Neighborhood Hits	21
SwissProt Accessions	P55273, Q13102, Q6FGE9	Gene names	CDKN2D
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

CNKR1_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.062396 (rank : 160)
Query Neighborhood Hits	260	Target Neighborhood Hits	154	Shared Neighborhood Hits	39
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CNKR2_HUMAN
θ value	θ > 10 (rank : 285)	NC score	0.052111 (rank : 194)
Query Neighborhood Hits	260	Target Neighborhood Hits	197	Shared Neighborhood Hits	52
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	θ > 10 (rank : 286)	NC score	0.052436 (rank : 191)
Query Neighborhood Hits	260	Target Neighborhood Hits	197	Shared Neighborhood Hits	51
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CT086_HUMAN
θ value	θ > 10 (rank : 287)	NC score	0.084849 (rank : 119)
Query Neighborhood Hits	260	Target Neighborhood Hits	277	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BZ19, Q4VXE6	Gene names	C20orf86
Domain Architecture
Description	Putative uncharacterized protein C20orf86.

CYH3_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.067394 (rank : 151)
Query Neighborhood Hits	260	Target Neighborhood Hits	137	Shared Neighborhood Hits	52
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

CYH3_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.060538 (rank : 165)
Query Neighborhood Hits	260	Target Neighborhood Hits	148	Shared Neighborhood Hits	57
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

CYH4_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.051944 (rank : 196)
Query Neighborhood Hits	260	Target Neighborhood Hits	135	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

CYH4_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.054254 (rank : 182)
Query Neighborhood Hits	260	Target Neighborhood Hits	134	Shared Neighborhood Hits	53
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

DAPP1_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.100590 (rank : 112)
Query Neighborhood Hits	260	Target Neighborhood Hits	227	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DP13A_HUMAN
θ value	θ > 10 (rank : 293)	NC score	0.104412 (rank : 108)
Query Neighborhood Hits	260	Target Neighborhood Hits	107	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13A_MOUSE
θ value	θ > 10 (rank : 294)	NC score	0.101355 (rank : 111)
Query Neighborhood Hits	260	Target Neighborhood Hits	96	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K3H0, Q3UJP7, Q69ZJ9, Q8BWZ8, Q8VCJ8, Q9CUW4	Gene names	Appl1, Dip13a, Kiaa1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13B_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.092301 (rank : 116)
Query Neighborhood Hits	260	Target Neighborhood Hits	58	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

DP13B_MOUSE
θ value	θ > 10 (rank : 296)	NC score	0.099547 (rank : 113)
Query Neighborhood Hits	260	Target Neighborhood Hits	58	Shared Neighborhood Hits	19
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

FGD1_HUMAN
θ value	θ > 10 (rank : 297)	NC score	0.052821 (rank : 189)
Query Neighborhood Hits	260	Target Neighborhood Hits	367	Shared Neighborhood Hits	46
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	θ > 10 (rank : 298)	NC score	0.050726 (rank : 202)
Query Neighborhood Hits	260	Target Neighborhood Hits	387	Shared Neighborhood Hits	45
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

GABP2_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.059984 (rank : 168)
Query Neighborhood Hits	260	Target Neighborhood Hits	454	Shared Neighborhood Hits	30
SwissProt Accessions	Q06547, Q06545, Q12940, Q12941, Q12942, Q8IYD0	Gene names	GABPB2, E4TF1B, GABPB, GABPB1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1) (Transcription factor E4TF1-53) (Transcription factor E4TF1-47) (Nuclear respiratory factor 2).

GABP2_MOUSE
θ value	θ > 10 (rank : 300)	NC score	0.059794 (rank : 169)
Query Neighborhood Hits	260	Target Neighborhood Hits	429	Shared Neighborhood Hits	30
SwissProt Accessions	Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2	Gene names	Gabpb2, Gabpb, Gabpb1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1).

GABP3_MOUSE
θ value	θ > 10 (rank : 301)	NC score	0.061434 (rank : 163)
Query Neighborhood Hits	260	Target Neighborhood Hits	330	Shared Neighborhood Hits	28
SwissProt Accessions	P81069	Gene names	Gabpb2
Domain Architecture	No domain graphic available
Description	GA-binding protein beta-2-1 chain (GABP subunit beta-2-1) (GABPB2-1).

GRP3_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.050410 (rank : 206)
Query Neighborhood Hits	260	Target Neighborhood Hits	131	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

HECD1_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.053688 (rank : 183)
Query Neighborhood Hits	260	Target Neighborhood Hits	371	Shared Neighborhood Hits	28
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

I5P2_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.155015 (rank : 101)
Query Neighborhood Hits	260	Target Neighborhood Hits	86	Shared Neighborhood Hits	48
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

IASPP_MOUSE
θ value	θ > 10 (rank : 305)	NC score	0.055606 (rank : 174)
Query Neighborhood Hits	260	Target Neighborhood Hits	1024	Shared Neighborhood Hits	47
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IKBB_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.055624 (rank : 173)
Query Neighborhood Hits	260	Target Neighborhood Hits	284	Shared Neighborhood Hits	26
SwissProt Accessions	Q15653, Q96BJ7	Gene names	NFKBIB, IKBB, TRIP9
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9).

IKBB_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.063873 (rank : 154)
Query Neighborhood Hits	260	Target Neighborhood Hits	284	Shared Neighborhood Hits	26
SwissProt Accessions	Q60778, Q9D6L5	Gene names	Nfkbib, Ikbb
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B).

MTPN_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.054920 (rank : 179)
Query Neighborhood Hits	260	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	P58546	Gene names	MTPN
Domain Architecture
Description	Myotrophin (Protein V-1).

MTPN_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.056338 (rank : 172)
Query Neighborhood Hits	260	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	P62774, P80144, Q543M6, Q9DCN8	Gene names	Mtpn, Gcdp
Domain Architecture	No domain graphic available
Description	Myotrophin (Protein V-1) (Granule cell differentiation protein).

MYPT1_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.053248 (rank : 184)
Query Neighborhood Hits	260	Target Neighborhood Hits	723	Shared Neighborhood Hits	44
SwissProt Accessions	O14974, Q86WU3, Q8NFR6, Q9BYH0	Gene names	PPP1R12A, MBS, MYPT1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit).

MYPT1_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.052319 (rank : 193)
Query Neighborhood Hits	260	Target Neighborhood Hits	539	Shared Neighborhood Hits	31
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

P85B_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.070359 (rank : 143)
Query Neighborhood Hits	260	Target Neighborhood Hits	543	Shared Neighborhood Hits	41
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 313)	NC score	0.055549 (rank : 176)
Query Neighborhood Hits	260	Target Neighborhood Hits	519	Shared Neighborhood Hits	37
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PLEK2_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.063220 (rank : 156)
Query Neighborhood Hits	260	Target Neighborhood Hits	101	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_MOUSE
θ value	θ > 10 (rank : 315)	NC score	0.060159 (rank : 167)
Query Neighborhood Hits	260	Target Neighborhood Hits	96	Shared Neighborhood Hits	43
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PLEK_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.077264 (rank : 127)
Query Neighborhood Hits	260	Target Neighborhood Hits	110	Shared Neighborhood Hits	48
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PLEK_MOUSE
θ value	θ > 10 (rank : 317)	NC score	0.062724 (rank : 158)
Query Neighborhood Hits	260	Target Neighborhood Hits	109	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

PSD10_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.050631 (rank : 204)
Query Neighborhood Hits	260	Target Neighborhood Hits	301	Shared Neighborhood Hits	26
SwissProt Accessions	O75832	Gene names	PSMD10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

RAI14_MOUSE
θ value	θ > 10 (rank : 319)	NC score	0.051356 (rank : 199)
Query Neighborhood Hits	260	Target Neighborhood Hits	1505	Shared Neighborhood Hits	69
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

RHG25_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.419818 (rank : 75)
Query Neighborhood Hits	260	Target Neighborhood Hits	550	Shared Neighborhood Hits	116
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

STAR8_HUMAN
θ value	θ > 10 (rank : 321)	NC score	0.335249 (rank : 85)
Query Neighborhood Hits	260	Target Neighborhood Hits	216	Shared Neighborhood Hits	60
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STAR8_MOUSE
θ value	θ > 10 (rank : 322)	NC score	0.336069 (rank : 84)
Query Neighborhood Hits	260	Target Neighborhood Hits	101	Shared Neighborhood Hits	57
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

USH1G_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.051647 (rank : 198)
Query Neighborhood Hits	260	Target Neighborhood Hits	267	Shared Neighborhood Hits	26
SwissProt Accessions	Q495M9, Q8N251	Gene names	USH1G, SANS
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein (Scaffold protein containing ankyrin repeats and SAM domain).

USH1G_MOUSE
θ value	θ > 10 (rank : 324)	NC score	0.051857 (rank : 197)
Query Neighborhood Hits	260	Target Neighborhood Hits	271	Shared Neighborhood Hits	26
SwissProt Accessions	Q80T11, Q80UG0	Gene names	Ush1g, Sans
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein homolog (Scaffold protein containing ankyrin repeats and SAM domain) (Jackson shaker protein).

Hits sorted by NC score

CEND1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	260	Target Neighborhood Hits	260	Shared Neighborhood Hits	260
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CEND1_HUMAN
NC score	0.987894 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	260	Target Neighborhood Hits	284	Shared Neighborhood Hits	196
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CEND2_HUMAN
NC score	0.953264 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	260	Target Neighborhood Hits	166	Shared Neighborhood Hits	132
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

CEND3_MOUSE
NC score	0.945697 (rank : 4)	θ value	0 (rank : 5)
Query Neighborhood Hits	260	Target Neighborhood Hits	228	Shared Neighborhood Hits	139
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CEND3_HUMAN
NC score	0.942897 (rank : 5)	θ value	0 (rank : 4)
Query Neighborhood Hits	260	Target Neighborhood Hits	275	Shared Neighborhood Hits	136
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

SMP1L_HUMAN
NC score	0.587481 (rank : 6)	θ value	3.18553e-13 (rank : 34)
Query Neighborhood Hits	260	Target Neighborhood Hits	74	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

SMP1L_MOUSE
NC score	0.586895 (rank : 7)	θ value	2.43908e-13 (rank : 32)
Query Neighborhood Hits	260	Target Neighborhood Hits	70	Shared Neighborhood Hits	38
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

SMAP1_MOUSE
NC score	0.585912 (rank : 8)	θ value	3.76295e-14 (rank : 27)
Query Neighborhood Hits	260	Target Neighborhood Hits	120	Shared Neighborhood Hits	40
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMAP1_HUMAN
NC score	0.583470 (rank : 9)	θ value	3.18553e-13 (rank : 33)
Query Neighborhood Hits	260	Target Neighborhood Hits	98	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IYB5, Q53H70, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4	Gene names	SMAP1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

CENA1_HUMAN
NC score	0.579599 (rank : 10)	θ value	2.52405e-10 (rank : 53)
Query Neighborhood Hits	260	Target Neighborhood Hits	87	Shared Neighborhood Hits	66
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

RHG09_HUMAN
NC score	0.574390 (rank : 11)	θ value	1.86753e-13 (rank : 30)
Query Neighborhood Hits	260	Target Neighborhood Hits	186	Shared Neighborhood Hits	62
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

OPHN1_MOUSE
NC score	0.557506 (rank : 12)	θ value	5.62301e-10 (rank : 56)
Query Neighborhood Hits	260	Target Neighborhood Hits	174	Shared Neighborhood Hits	67
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

GMIP_MOUSE
NC score	0.550721 (rank : 13)	θ value	4.16044e-13 (rank : 35)
Query Neighborhood Hits	260	Target Neighborhood Hits	202	Shared Neighborhood Hits	64
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

OPHN1_HUMAN
NC score	0.548463 (rank : 14)	θ value	2.13673e-09 (rank : 59)
Query Neighborhood Hits	260	Target Neighborhood Hits	161	Shared Neighborhood Hits	64
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

RGAP1_MOUSE
NC score	0.548346 (rank : 15)	θ value	1.74796e-11 (rank : 42)
Query Neighborhood Hits	260	Target Neighborhood Hits	185	Shared Neighborhood Hits	62
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

CENA2_HUMAN
NC score	0.546020 (rank : 16)	θ value	2.79066e-09 (rank : 60)
Query Neighborhood Hits	260	Target Neighborhood Hits	83	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

RGAP1_HUMAN
NC score	0.544324 (rank : 17)	θ value	3.29651e-10 (rank : 54)
Query Neighborhood Hits	260	Target Neighborhood Hits	189	Shared Neighborhood Hits	61
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

CENA2_MOUSE
NC score	0.541948 (rank : 18)	θ value	8.11959e-09 (rank : 62)
Query Neighborhood Hits	260	Target Neighborhood Hits	68	Shared Neighborhood Hits	54
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

GMIP_HUMAN
NC score	0.535983 (rank : 19)	θ value	8.67504e-11 (rank : 51)
Query Neighborhood Hits	260	Target Neighborhood Hits	225	Shared Neighborhood Hits	62
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

ARFG3_MOUSE
NC score	0.534963 (rank : 20)	θ value	1.38499e-08 (rank : 63)
Query Neighborhood Hits	260	Target Neighborhood Hits	80	Shared Neighborhood Hits	40
SwissProt Accessions	Q9D8S3, Q99KN8	Gene names	Arfgap3
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ARFG3_HUMAN
NC score	0.534372 (rank : 21)	θ value	6.87365e-08 (rank : 65)
Query Neighborhood Hits	260	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

RHG06_HUMAN
NC score	0.532979 (rank : 22)	θ value	6.64225e-11 (rank : 49)
Query Neighborhood Hits	260	Target Neighborhood Hits	114	Shared Neighborhood Hits	59
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

DDFL1_HUMAN
NC score	0.531905 (rank : 23)	θ value	7.58209e-15 (rank : 22)
Query Neighborhood Hits	260	Target Neighborhood Hits	353	Shared Neighborhood Hits	67
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

RHG06_MOUSE
NC score	0.531863 (rank : 24)	θ value	1.133e-10 (rank : 52)
Query Neighborhood Hits	260	Target Neighborhood Hits	105	Shared Neighborhood Hits	58
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

GRLF1_HUMAN
NC score	0.531384 (rank : 25)	θ value	4.30538e-10 (rank : 55)
Query Neighborhood Hits	260	Target Neighborhood Hits	167	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

RHG05_MOUSE
NC score	0.531131 (rank : 26)	θ value	6.41864e-14 (rank : 28)
Query Neighborhood Hits	260	Target Neighborhood Hits	165	Shared Neighborhood Hits	64
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG12_HUMAN
NC score	0.530899 (rank : 27)	θ value	2.98157e-11 (rank : 44)
Query Neighborhood Hits	260	Target Neighborhood Hits	190	Shared Neighborhood Hits	62
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
NC score	0.530559 (rank : 28)	θ value	2.98157e-11 (rank : 45)
Query Neighborhood Hits	260	Target Neighborhood Hits	204	Shared Neighborhood Hits	64
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG05_HUMAN
NC score	0.527823 (rank : 29)	θ value	1.86753e-13 (rank : 29)
Query Neighborhood Hits	260	Target Neighborhood Hits	158	Shared Neighborhood Hits	62
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

ARFG1_MOUSE
NC score	0.521890 (rank : 30)	θ value	2.21117e-06 (rank : 71)
Query Neighborhood Hits	260	Target Neighborhood Hits	51	Shared Neighborhood Hits	39
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

RHG26_HUMAN
NC score	0.513584 (rank : 31)	θ value	2.36244e-08 (rank : 64)
Query Neighborhood Hits	260	Target Neighborhood Hits	281	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

CENB1_HUMAN
NC score	0.512123 (rank : 32)	θ value	5.07402e-19 (rank : 14)
Query Neighborhood Hits	260	Target Neighborhood Hits	383	Shared Neighborhood Hits	86
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

CENB5_HUMAN
NC score	0.511814 (rank : 33)	θ value	9.24701e-21 (rank : 9)
Query Neighborhood Hits	260	Target Neighborhood Hits	395	Shared Neighborhood Hits	87
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CENG1_MOUSE
NC score	0.511463 (rank : 34)	θ value	4.15078e-21 (rank : 7)
Query Neighborhood Hits	260	Target Neighborhood Hits	531	Shared Neighborhood Hits	56
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

DDFL1_MOUSE
NC score	0.510282 (rank : 35)	θ value	2.7842e-17 (rank : 16)
Query Neighborhood Hits	260	Target Neighborhood Hits	324	Shared Neighborhood Hits	61
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

CENB2_HUMAN
NC score	0.509672 (rank : 36)	θ value	4.9032e-22 (rank : 6)
Query Neighborhood Hits	260	Target Neighborhood Hits	425	Shared Neighborhood Hits	90
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

ARFG1_HUMAN
NC score	0.508753 (rank : 37)	θ value	1.69304e-06 (rank : 70)
Query Neighborhood Hits	260	Target Neighborhood Hits	60	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N6T3, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0	Gene names	ARFGAP1, ARF1GAP
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

CHIO_MOUSE
NC score	0.508575 (rank : 38)	θ value	6.64225e-11 (rank : 48)
Query Neighborhood Hits	260	Target Neighborhood Hits	130	Shared Neighborhood Hits	59
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

RHG18_HUMAN
NC score	0.506620 (rank : 39)	θ value	3.41135e-07 (rank : 68)
Query Neighborhood Hits	260	Target Neighborhood Hits	90	Shared Neighborhood Hits	57
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

CENG1_HUMAN
NC score	0.506056 (rank : 40)	θ value	7.0802e-21 (rank : 8)
Query Neighborhood Hits	260	Target Neighborhood Hits	544	Shared Neighborhood Hits	55
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

ABR_HUMAN
NC score	0.502393 (rank : 41)	θ value	2.20605e-14 (rank : 25)
Query Neighborhood Hits	260	Target Neighborhood Hits	166	Shared Neighborhood Hits	66
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

TCGAP_MOUSE
NC score	0.501698 (rank : 42)	θ value	1.63604e-09 (rank : 58)
Query Neighborhood Hits	260	Target Neighborhood Hits	409	Shared Neighborhood Hits	63
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

DDEF1_MOUSE
NC score	0.501178 (rank : 43)	θ value	3.07829e-16 (rank : 18)
Query Neighborhood Hits	260	Target Neighborhood Hits	592	Shared Neighborhood Hits	69
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

RBP1_MOUSE
NC score	0.500570 (rank : 44)	θ value	7.84624e-12 (rank : 39)
Query Neighborhood Hits	260	Target Neighborhood Hits	493	Shared Neighborhood Hits	77
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RHG18_MOUSE
NC score	0.499829 (rank : 45)	θ value	6.87365e-08 (rank : 67)
Query Neighborhood Hits	260	Target Neighborhood Hits	110	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

CENG3_HUMAN
NC score	0.498670 (rank : 46)	θ value	1.33526e-19 (rank : 11)
Query Neighborhood Hits	260	Target Neighborhood Hits	455	Shared Neighborhood Hits	53
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_MOUSE
NC score	0.498236 (rank : 47)	θ value	1.33526e-19 (rank : 12)
Query Neighborhood Hits	260	Target Neighborhood Hits	467	Shared Neighborhood Hits	55
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

BCR_HUMAN
NC score	0.492928 (rank : 48)	θ value	2.43908e-13 (rank : 31)
Query Neighborhood Hits	260	Target Neighborhood Hits	204	Shared Neighborhood Hits	67
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

DDEF2_HUMAN
NC score	0.492697 (rank : 49)	θ value	6.20254e-17 (rank : 17)
Query Neighborhood Hits	260	Target Neighborhood Hits	599	Shared Neighborhood Hits	74
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

CHIN_MOUSE
NC score	0.491219 (rank : 50)	θ value	3.52202e-12 (rank : 37)
Query Neighborhood Hits	260	Target Neighborhood Hits	229	Shared Neighborhood Hits	61
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

3BP1_MOUSE
NC score	0.490134 (rank : 51)	θ value	4.1701e-05 (rank : 81)
Query Neighborhood Hits	260	Target Neighborhood Hits	238	Shared Neighborhood Hits	66
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

TAGAP_HUMAN
NC score	0.489355 (rank : 52)	θ value	6.21693e-09 (rank : 61)
Query Neighborhood Hits	260	Target Neighborhood Hits	82	Shared Neighborhood Hits	55
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

RBP1_HUMAN
NC score	0.489321 (rank : 53)	θ value	6.00763e-12 (rank : 38)
Query Neighborhood Hits	260	Target Neighborhood Hits	521	Shared Neighborhood Hits	76
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

DDEF2_MOUSE
NC score	0.488960 (rank : 54)	θ value	2.13179e-17 (rank : 15)
Query Neighborhood Hits	260	Target Neighborhood Hits	625	Shared Neighborhood Hits	74
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

CHIN_HUMAN
NC score	0.487639 (rank : 55)	θ value	1.33837e-11 (rank : 41)
Query Neighborhood Hits	260	Target Neighborhood Hits	227	Shared Neighborhood Hits	60
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

3BP1_HUMAN
NC score	0.487107 (rank : 56)	θ value	2.88788e-06 (rank : 73)
Query Neighborhood Hits	260	Target Neighborhood Hits	376	Shared Neighborhood Hits	68
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

CHIO_HUMAN
NC score	0.486451 (rank : 57)	θ value	3.89403e-11 (rank : 46)
Query Neighborhood Hits	260	Target Neighborhood Hits	220	Shared Neighborhood Hits	60
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

RHG01_HUMAN
NC score	0.483192 (rank : 58)	θ value	6.87365e-08 (rank : 66)
Query Neighborhood Hits	260	Target Neighborhood Hits	75	Shared Neighborhood Hits	58
SwissProt Accessions	Q07960	Gene names	ARHGAP1, CDC42GAP, RHOGAP1
Domain Architecture
Description	Rho-GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (CDC42 GTPase-activating protein) (p50-RhoGAP).

TAGAP_MOUSE
NC score	0.480414 (rank : 59)	θ value	1.29631e-06 (rank : 69)
Query Neighborhood Hits	260	Target Neighborhood Hits	83	Shared Neighborhood Hits	57
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

RHG04_HUMAN
NC score	0.479120 (rank : 60)	θ value	7.84624e-12 (rank : 40)
Query Neighborhood Hits	260	Target Neighborhood Hits	307	Shared Neighborhood Hits	59
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

CENG2_MOUSE
NC score	0.477878 (rank : 61)	θ value	1.74391e-19 (rank : 13)
Query Neighborhood Hits	260	Target Neighborhood Hits	463	Shared Neighborhood Hits	54
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

CENG2_HUMAN
NC score	0.475294 (rank : 62)	θ value	7.82807e-20 (rank : 10)
Query Neighborhood Hits	260	Target Neighborhood Hits	471	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

GIT2_HUMAN
NC score	0.473232 (rank : 63)	θ value	2.88119e-14 (rank : 26)
Query Neighborhood Hits	260	Target Neighborhood Hits	381	Shared Neighborhood Hits	51
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

GIT2_MOUSE
NC score	0.472175 (rank : 64)	θ value	3.40345e-15 (rank : 21)
Query Neighborhood Hits	260	Target Neighborhood Hits	323	Shared Neighborhood Hits	47
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

SRGP2_HUMAN
NC score	0.469070 (rank : 65)	θ value	1.74796e-11 (rank : 43)
Query Neighborhood Hits	260	Target Neighborhood Hits	331	Shared Neighborhood Hits	62
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

RHG25_MOUSE
NC score	0.469027 (rank : 66)	θ value	2.88788e-06 (rank : 74)
Query Neighborhood Hits	260	Target Neighborhood Hits	492	Shared Neighborhood Hits	117
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

SRGP2_MOUSE
NC score	0.463555 (rank : 67)	θ value	6.64225e-11 (rank : 50)
Query Neighborhood Hits	260	Target Neighborhood Hits	324	Shared Neighborhood Hits	64
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

GIT1_HUMAN
NC score	0.462997 (rank : 68)	θ value	1.68911e-14 (rank : 23)
Query Neighborhood Hits	260	Target Neighborhood Hits	336	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

GIT1_MOUSE
NC score	0.461441 (rank : 69)	θ value	1.68911e-14 (rank : 24)
Query Neighborhood Hits	260	Target Neighborhood Hits	341	Shared Neighborhood Hits	48
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

SRGP1_HUMAN
NC score	0.460482 (rank : 70)	θ value	2.69671e-12 (rank : 36)
Query Neighborhood Hits	260	Target Neighborhood Hits	390	Shared Neighborhood Hits	67
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

FNBP2_HUMAN
NC score	0.459953 (rank : 71)	θ value	3.89403e-11 (rank : 47)
Query Neighborhood Hits	260	Target Neighborhood Hits	432	Shared Neighborhood Hits	68
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

TCGAP_HUMAN
NC score	0.455514 (rank : 72)	θ value	1.63604e-09 (rank : 57)
Query Neighborhood Hits	260	Target Neighborhood Hits	872	Shared Neighborhood Hits	73
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

RHG08_HUMAN
NC score	0.455266 (rank : 73)	θ value	1.87187e-05 (rank : 77)
Query Neighborhood Hits	260	Target Neighborhood Hits	88	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NSG0, O75983, O95695, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NVX8, Q9NXL1, Q9UH20	Gene names	ARHGAP8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

RHG08_MOUSE
NC score	0.455219 (rank : 74)	θ value	3.19293e-05 (rank : 80)
Query Neighborhood Hits	260	Target Neighborhood Hits	73	Shared Neighborhood Hits	58
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

RHG25_HUMAN
NC score	0.419818 (rank : 75)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	260	Target Neighborhood Hits	550	Shared Neighborhood Hits	116
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG07_MOUSE
NC score	0.395113 (rank : 76)	θ value	0.00134147 (rank : 89)
Query Neighborhood Hits	260	Target Neighborhood Hits	103	Shared Neighborhood Hits	60
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

CE005_HUMAN
NC score	0.392002 (rank : 77)	θ value	2.44474e-05 (rank : 78)
Query Neighborhood Hits	260	Target Neighborhood Hits	213	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

CE005_MOUSE
NC score	0.389520 (rank : 78)	θ value	2.44474e-05 (rank : 79)
Query Neighborhood Hits	260	Target Neighborhood Hits	238	Shared Neighborhood Hits	65
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

RHG07_HUMAN
NC score	0.389164 (rank : 79)	θ value	0.00175202 (rank : 90)
Query Neighborhood Hits	260	Target Neighborhood Hits	108	Shared Neighborhood Hits	59
SwissProt Accessions	Q96QB1, O14868, O43199, Q9C0E0	Gene names	DLC1, ARHGAP7, KIAA1723, STARD12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

NUPL_HUMAN
NC score	0.379255 (rank : 80)	θ value	4.1701e-05 (rank : 82)
Query Neighborhood Hits	260	Target Neighborhood Hits	68	Shared Neighborhood Hits	37
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).

NUPL_MOUSE
NC score	0.375498 (rank : 81)	θ value	4.1701e-05 (rank : 83)
Query Neighborhood Hits	260	Target Neighborhood Hits	113	Shared Neighborhood Hits	36
SwissProt Accessions	Q8K2K6, O70448, Q8BQL5, Q8CDK9	Gene names	Hrb, Rip
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein homolog).

STA13_HUMAN
NC score	0.356028 (rank : 82)	θ value	0.0193708 (rank : 96)
Query Neighborhood Hits	260	Target Neighborhood Hits	89	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

STA13_MOUSE
NC score	0.352427 (rank : 83)	θ value	0.0193708 (rank : 97)
Query Neighborhood Hits	260	Target Neighborhood Hits	89	Shared Neighborhood Hits	56
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

STAR8_MOUSE
NC score	0.336069 (rank : 84)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	260	Target Neighborhood Hits	101	Shared Neighborhood Hits	57
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STAR8_HUMAN
NC score	0.335249 (rank : 85)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	260	Target Neighborhood Hits	216	Shared Neighborhood Hits	60
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

HRBL_HUMAN
NC score	0.324189 (rank : 86)	θ value	0.0148317 (rank : 95)
Query Neighborhood Hits	260	Target Neighborhood Hits	179	Shared Neighborhood Hits	37
SwissProt Accessions	O95081, O75429, Q96AB9, Q96GL4	Gene names	HRBL, RABR
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

HRBL_MOUSE
NC score	0.308890 (rank : 87)	θ value	0.0252991 (rank : 99)
Query Neighborhood Hits	260	Target Neighborhood Hits	269	Shared Neighborhood Hits	38
SwissProt Accessions	Q80WC7, Q8BKS5, Q99J67	Gene names	Hrbl, Rabr
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

MYO9B_MOUSE
NC score	0.301387 (rank : 88)	θ value	1.52774e-15 (rank : 20)
Query Neighborhood Hits	260	Target Neighborhood Hits	311	Shared Neighborhood Hits	64
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

MYO9B_HUMAN
NC score	0.298775 (rank : 89)	θ value	3.07829e-16 (rank : 19)
Query Neighborhood Hits	260	Target Neighborhood Hits	641	Shared Neighborhood Hits	76
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

P85A_HUMAN
NC score	0.274647 (rank : 90)	θ value	2.21117e-06 (rank : 72)
Query Neighborhood Hits	260	Target Neighborhood Hits	479	Shared Neighborhood Hits	66
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
NC score	0.268628 (rank : 91)	θ value	1.09739e-05 (rank : 76)
Query Neighborhood Hits	260	Target Neighborhood Hits	435	Shared Neighborhood Hits	64
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

K1688_MOUSE
NC score	0.266322 (rank : 92)	θ value	6.88961 (rank : 234)
Query Neighborhood Hits	260	Target Neighborhood Hits	188	Shared Neighborhood Hits	60
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

K1688_HUMAN
NC score	0.258955 (rank : 93)	θ value	3.0926 (rank : 188)
Query Neighborhood Hits	260	Target Neighborhood Hits	217	Shared Neighborhood Hits	58
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

PKHA1_HUMAN
NC score	0.244032 (rank : 94)	θ value	0.00020696 (rank : 85)
Query Neighborhood Hits	260	Target Neighborhood Hits	127	Shared Neighborhood Hits	63
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
NC score	0.240113 (rank : 95)	θ value	9.29e-05 (rank : 84)
Query Neighborhood Hits	260	Target Neighborhood Hits	120	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_MOUSE
NC score	0.200229 (rank : 96)	θ value	0.0431538 (rank : 102)
Query Neighborhood Hits	260	Target Neighborhood Hits	116	Shared Neighborhood Hits	57
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA6_MOUSE
NC score	0.195697 (rank : 97)	θ value	0.00102713 (rank : 88)
Query Neighborhood Hits	260	Target Neighborhood Hits	591	Shared Neighborhood Hits	72
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_HUMAN
NC score	0.194632 (rank : 98)	θ value	0.000461057 (rank : 86)
Query Neighborhood Hits	260	Target Neighborhood Hits	556	Shared Neighborhood Hits	71
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA2_HUMAN
NC score	0.175196 (rank : 99)	θ value	0.62314 (rank : 139)
Query Neighborhood Hits	260	Target Neighborhood Hits	119	Shared Neighborhood Hits	60
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

OCRL_HUMAN
NC score	0.166663 (rank : 100)	θ value	4.03905 (rank : 201)
Query Neighborhood Hits	260	Target Neighborhood Hits	77	Shared Neighborhood Hits	49
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).

I5P2_HUMAN
NC score	0.155015 (rank : 101)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	260	Target Neighborhood Hits	86	Shared Neighborhood Hits	48
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

PKHA4_MOUSE
NC score	0.138394 (rank : 102)	θ value	0.125558 (rank : 120)
Query Neighborhood Hits	260	Target Neighborhood Hits	202	Shared Neighborhood Hits	49
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_HUMAN
NC score	0.128178 (rank : 103)	θ value	0.365318 (rank : 134)
Query Neighborhood Hits	260	Target Neighborhood Hits	283	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA5_HUMAN
NC score	0.126935 (rank : 104)	θ value	0.0961366 (rank : 115)
Query Neighborhood Hits	260	Target Neighborhood Hits	455	Shared Neighborhood Hits	74
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

DGKH_HUMAN
NC score	0.126806 (rank : 105)	θ value	0.0148317 (rank : 93)
Query Neighborhood Hits	260	Target Neighborhood Hits	255	Shared Neighborhood Hits	77
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

GAB2_HUMAN
NC score	0.111959 (rank : 106)	θ value	0.0252991 (rank : 98)
Query Neighborhood Hits	260	Target Neighborhood Hits	188	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

GAB2_MOUSE
NC score	0.110243 (rank : 107)	θ value	0.125558 (rank : 119)
Query Neighborhood Hits	260	Target Neighborhood Hits	220	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

DP13A_HUMAN
NC score	0.104412 (rank : 108)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	260	Target Neighborhood Hits	107	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DAPP1_MOUSE
NC score	0.103671 (rank : 109)	θ value	8.99809 (rank : 245)
Query Neighborhood Hits	260	Target Neighborhood Hits	225	Shared Neighborhood Hits	55
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DGKD_HUMAN
NC score	0.103513 (rank : 110)	θ value	0.813845 (rank : 144)
Query Neighborhood Hits	260	Target Neighborhood Hits	231	Shared Neighborhood Hits	62
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

DP13A_MOUSE
NC score	0.101355 (rank : 111)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	260	Target Neighborhood Hits	96	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K3H0, Q3UJP7, Q69ZJ9, Q8BWZ8, Q8VCJ8, Q9CUW4	Gene names	Appl1, Dip13a, Kiaa1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DAPP1_HUMAN
NC score	0.100590 (rank : 112)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	260	Target Neighborhood Hits	227	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DP13B_MOUSE
NC score	0.099547 (rank : 113)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	260	Target Neighborhood Hits	58	Shared Neighborhood Hits	19
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

PKHA3_HUMAN
NC score	0.092790 (rank : 114)	θ value	0.163984 (rank : 123)
Query Neighborhood Hits	260	Target Neighborhood Hits	66	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PKHA3_MOUSE
NC score	0.092363 (rank : 115)	θ value	0.21417 (rank : 127)
Query Neighborhood Hits	260	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

DP13B_HUMAN
NC score	0.092301 (rank : 116)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	260	Target Neighborhood Hits	58	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

MYO10_HUMAN
NC score	0.092022 (rank : 117)	θ value	4.92598e-06 (rank : 75)
Query Neighborhood Hits	260	Target Neighborhood Hits	920	Shared Neighborhood Hits	90
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

GAB1_HUMAN
NC score	0.087852 (rank : 118)	θ value	1.81305 (rank : 165)
Query Neighborhood Hits	260	Target Neighborhood Hits	279	Shared Neighborhood Hits	37
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

CT086_HUMAN
NC score	0.084849 (rank : 119)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	260	Target Neighborhood Hits	277	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BZ19, Q4VXE6	Gene names	C20orf86
Domain Architecture
Description	Putative uncharacterized protein C20orf86.

RASA3_HUMAN
NC score	0.083706 (rank : 120)	θ value	0.00869519 (rank : 92)
Query Neighborhood Hits	260	Target Neighborhood Hits	166	Shared Neighborhood Hits	39
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

CSKI2_MOUSE
NC score	0.081867 (rank : 121)	θ value	0.813845 (rank : 141)
Query Neighborhood Hits	260	Target Neighborhood Hits	812	Shared Neighborhood Hits	70
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

GAB1_MOUSE
NC score	0.081704 (rank : 122)	θ value	4.03905 (rank : 199)
Query Neighborhood Hits	260	Target Neighborhood Hits	233	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

C43BP_MOUSE
NC score	0.081210 (rank : 123)	θ value	1.38821 (rank : 156)
Query Neighborhood Hits	260	Target Neighborhood Hits	91	Shared Neighborhood Hits	40
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

CSKI2_HUMAN
NC score	0.080358 (rank : 124)	θ value	0.813845 (rank : 140)
Query Neighborhood Hits	260	Target Neighborhood Hits	747	Shared Neighborhood Hits	65
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

RASA2_MOUSE
NC score	0.078880 (rank : 125)	θ value	0.0736092 (rank : 109)
Query Neighborhood Hits	260	Target Neighborhood Hits	159	Shared Neighborhood Hits	39
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

CYH1_MOUSE
NC score	0.077407 (rank : 126)	θ value	0.813845 (rank : 142)
Query Neighborhood Hits	260	Target Neighborhood Hits	176	Shared Neighborhood Hits	57
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

PLEK_HUMAN
NC score	0.077264 (rank : 127)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	260	Target Neighborhood Hits	110	Shared Neighborhood Hits	48
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

SWP70_MOUSE
NC score	0.076987 (rank : 128)	θ value	0.0330416 (rank : 101)
Query Neighborhood Hits	260	Target Neighborhood Hits	1097	Shared Neighborhood Hits	88
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

C43BP_HUMAN
NC score	0.076656 (rank : 129)	θ value	2.36792 (rank : 173)
Query Neighborhood Hits	260	Target Neighborhood Hits	87	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

CYH1_HUMAN
NC score	0.076039 (rank : 130)	θ value	2.36792 (rank : 175)
Query Neighborhood Hits	260	Target Neighborhood Hits	184	Shared Neighborhood Hits	60
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

TNKS1_HUMAN
NC score	0.076027 (rank : 131)	θ value	0.163984 (rank : 124)
Query Neighborhood Hits	260	Target Neighborhood Hits	477	Shared Neighborhood Hits	45
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

MRIP_MOUSE
NC score	0.075830 (rank : 132)	θ value	0.0252991 (rank : 100)
Query Neighborhood Hits	260	Target Neighborhood Hits	569	Shared Neighborhood Hits	62
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

SWP70_HUMAN
NC score	0.075815 (rank : 133)	θ value	0.0736092 (rank : 112)
Query Neighborhood Hits	260	Target Neighborhood Hits	973	Shared Neighborhood Hits	84
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

AB1IP_HUMAN
NC score	0.074948 (rank : 134)	θ value	0.0563607 (rank : 103)
Query Neighborhood Hits	260	Target Neighborhood Hits	213	Shared Neighborhood Hits	18
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

AB1IP_MOUSE
NC score	0.074162 (rank : 135)	θ value	0.0563607 (rank : 104)
Query Neighborhood Hits	260	Target Neighborhood Hits	181	Shared Neighborhood Hits	16
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

ANR41_HUMAN
NC score	0.073012 (rank : 136)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	260	Target Neighborhood Hits	332	Shared Neighborhood Hits	27
SwissProt Accessions	Q8NAG6, Q8N8J8	Gene names	ANKRD41
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 41.

OSBP1_HUMAN
NC score	0.072092 (rank : 137)	θ value	8.99809 (rank : 254)
Query Neighborhood Hits	260	Target Neighborhood Hits	180	Shared Neighborhood Hits	52
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

CSKI1_HUMAN
NC score	0.071942 (rank : 138)	θ value	6.88961 (rank : 225)
Query Neighborhood Hits	260	Target Neighborhood Hits	997	Shared Neighborhood Hits	67
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

RASA2_HUMAN
NC score	0.071364 (rank : 139)	θ value	0.21417 (rank : 128)
Query Neighborhood Hits	260	Target Neighborhood Hits	157	Shared Neighborhood Hits	34
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RASA3_MOUSE
NC score	0.071146 (rank : 140)	θ value	1.06291 (rank : 152)
Query Neighborhood Hits	260	Target Neighborhood Hits	144	Shared Neighborhood Hits	36
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

OSBL9_HUMAN
NC score	0.070829 (rank : 141)	θ value	0.62314 (rank : 138)
Query Neighborhood Hits	260	Target Neighborhood Hits	138	Shared Neighborhood Hits	45
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

CYH2_HUMAN
NC score	0.070617 (rank : 142)	θ value	6.88961 (rank : 226)
Query Neighborhood Hits	260	Target Neighborhood Hits	175	Shared Neighborhood Hits	57
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

P85B_HUMAN
NC score	0.070359 (rank : 143)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	260	Target Neighborhood Hits	543	Shared Neighborhood Hits	41
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

CYH2_MOUSE
NC score	0.070312 (rank : 144)	θ value	6.88961 (rank : 227)
Query Neighborhood Hits	260	Target Neighborhood Hits	171	Shared Neighborhood Hits	56
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CSKI1_MOUSE
NC score	0.069681 (rank : 145)	θ value	5.27518 (rank : 212)
Query Neighborhood Hits	260	Target Neighborhood Hits	1031	Shared Neighborhood Hits	62
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

TNKS2_HUMAN
NC score	0.069651 (rank : 146)	θ value	0.279714 (rank : 132)
Query Neighborhood Hits	260	Target Neighborhood Hits	361	Shared Neighborhood Hits	35
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

ANR37_MOUSE
NC score	0.069552 (rank : 147)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	260	Target Neighborhood Hits	237	Shared Neighborhood Hits	24
SwissProt Accessions	Q569N2, Q8CHS0	Gene names	Ankrd37
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37.

MRIP_HUMAN
NC score	0.068536 (rank : 148)	θ value	0.163984 (rank : 122)
Query Neighborhood Hits	260	Target Neighborhood Hits	578	Shared Neighborhood Hits	65
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

ANR46_HUMAN
NC score	0.067976 (rank : 149)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	260	Target Neighborhood Hits	281	Shared Neighborhood Hits	25
SwissProt Accessions	Q86W74, Q6P9B7	Gene names	ANKRD46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

ANR46_MOUSE
NC score	0.067462 (rank : 150)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	260	Target Neighborhood Hits	274	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BTZ5, Q1LZK9, Q8BV97	Gene names	Ankrd46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

CYH3_HUMAN
NC score	0.067394 (rank : 151)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	260	Target Neighborhood Hits	137	Shared Neighborhood Hits	52
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

ANR39_MOUSE
NC score	0.065033 (rank : 152)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	260	Target Neighborhood Hits	284	Shared Neighborhood Hits	26
SwissProt Accessions	Q9D2X0	Gene names	Ankrd39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

3BP2_HUMAN
NC score	0.064506 (rank : 153)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	260	Target Neighborhood Hits	296	Shared Neighborhood Hits	39
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

IKBB_MOUSE
NC score	0.063873 (rank : 154)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	260	Target Neighborhood Hits	284	Shared Neighborhood Hits	26
SwissProt Accessions	Q60778, Q9D6L5	Gene names	Nfkbib, Ikbb
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B).

ANR39_HUMAN
NC score	0.063824 (rank : 155)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	260	Target Neighborhood Hits	285	Shared Neighborhood Hits	26
SwissProt Accessions	Q53RE8, Q59FU2, Q8N5X5, Q9P0S5	Gene names	ANKRD39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

PLEK2_HUMAN
NC score	0.063220 (rank : 156)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	260	Target Neighborhood Hits	101	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

RAPH1_HUMAN
NC score	0.062952 (rank : 157)	θ value	0.0961366 (rank : 116)
Query Neighborhood Hits	260	Target Neighborhood Hits	593	Shared Neighborhood Hits	27
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

PLEK_MOUSE
NC score	0.062724 (rank : 158)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	260	Target Neighborhood Hits	109	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

SASH1_MOUSE
NC score	0.062572 (rank : 159)	θ value	0.279714 (rank : 131)
Query Neighborhood Hits	260	Target Neighborhood Hits	263	Shared Neighborhood Hits	39
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

CNKR1_HUMAN
NC score	0.062396 (rank : 160)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	260	Target Neighborhood Hits	154	Shared Neighborhood Hits	39
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

FGD4_MOUSE
NC score	0.062241 (rank : 161)	θ value	0.0563607 (rank : 106)
Query Neighborhood Hits	260	Target Neighborhood Hits	227	Shared Neighborhood Hits	48
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

SASH1_HUMAN
NC score	0.062144 (rank : 162)	θ value	1.38821 (rank : 164)
Query Neighborhood Hits	260	Target Neighborhood Hits	292	Shared Neighborhood Hits	36
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

GABP3_MOUSE
NC score	0.061434 (rank : 163)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	260	Target Neighborhood Hits	330	Shared Neighborhood Hits	28
SwissProt Accessions	P81069	Gene names	Gabpb2
Domain Architecture	No domain graphic available
Description	GA-binding protein beta-2-1 chain (GABP subunit beta-2-1) (GABPB2-1).

ANS4B_MOUSE
NC score	0.060664 (rank : 164)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	260	Target Neighborhood Hits	294	Shared Neighborhood Hits	25
SwissProt Accessions	Q8K3X6, Q9D8A5	Gene names	Anks4b, Harp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

CYH3_MOUSE
NC score	0.060538 (rank : 165)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	260	Target Neighborhood Hits	148	Shared Neighborhood Hits	57
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

RAI14_HUMAN
NC score	0.060441 (rank : 166)	θ value	0.813845 (rank : 148)
Query Neighborhood Hits	260	Target Neighborhood Hits	1367	Shared Neighborhood Hits	70
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

PLEK2_MOUSE
NC score	0.060159 (rank : 167)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	260	Target Neighborhood Hits	96	Shared Neighborhood Hits	43
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

GABP2_HUMAN
NC score	0.059984 (rank : 168)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	260	Target Neighborhood Hits	454	Shared Neighborhood Hits	30
SwissProt Accessions	Q06547, Q06545, Q12940, Q12941, Q12942, Q8IYD0	Gene names	GABPB2, E4TF1B, GABPB, GABPB1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1) (Transcription factor E4TF1-53) (Transcription factor E4TF1-47) (Nuclear respiratory factor 2).

GABP2_MOUSE
NC score	0.059794 (rank : 169)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	260	Target Neighborhood Hits	429	Shared Neighborhood Hits	30
SwissProt Accessions	Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2	Gene names	Gabpb2, Gabpb, Gabpb1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1).

ANR37_HUMAN
NC score	0.059700 (rank : 170)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	260	Target Neighborhood Hits	247	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z713	Gene names	ANKRD37, LPR2BP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37 (Low-density lipoprotein receptor-related protein 2-binding protein) (hLrp2bp).

FARP1_HUMAN
NC score	0.057721 (rank : 171)	θ value	0.21417 (rank : 126)
Query Neighborhood Hits	260	Target Neighborhood Hits	241	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

MTPN_MOUSE
NC score	0.056338 (rank : 172)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	260	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	P62774, P80144, Q543M6, Q9DCN8	Gene names	Mtpn, Gcdp
Domain Architecture	No domain graphic available
Description	Myotrophin (Protein V-1) (Granule cell differentiation protein).

IKBB_HUMAN
NC score	0.055624 (rank : 173)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	260	Target Neighborhood Hits	284	Shared Neighborhood Hits	26
SwissProt Accessions	Q15653, Q96BJ7	Gene names	NFKBIB, IKBB, TRIP9
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9).

IASPP_MOUSE
NC score	0.055606 (rank : 174)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	260	Target Neighborhood Hits	1024	Shared Neighborhood Hits	47
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ANS4B_HUMAN
NC score	0.055591 (rank : 175)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	260	Target Neighborhood Hits	289	Shared Neighborhood Hits	25
SwissProt Accessions	Q8N8V4	Gene names	ANKS4B, HARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

P85B_MOUSE
NC score	0.055549 (rank : 176)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	260	Target Neighborhood Hits	519	Shared Neighborhood Hits	37
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

DGKK_HUMAN
NC score	0.055352 (rank : 177)	θ value	0.0736092 (rank : 107)
Query Neighborhood Hits	260	Target Neighborhood Hits	378	Shared Neighborhood Hits	28
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

OSBP2_HUMAN
NC score	0.055318 (rank : 178)	θ value	1.81305 (rank : 167)
Query Neighborhood Hits	260	Target Neighborhood Hits	154	Shared Neighborhood Hits	41
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

MTPN_HUMAN
NC score	0.054920 (rank : 179)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	260	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	P58546	Gene names	MTPN
Domain Architecture
Description	Myotrophin (Protein V-1).

CDN2D_HUMAN
NC score	0.054770 (rank : 180)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	260	Target Neighborhood Hits	268	Shared Neighborhood Hits	21
SwissProt Accessions	P55273, Q13102, Q6FGE9	Gene names	CDKN2D
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

3BP2_MOUSE
NC score	0.054505 (rank : 181)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	260	Target Neighborhood Hits	142	Shared Neighborhood Hits	34
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

CYH4_MOUSE
NC score	0.054254 (rank : 182)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	260	Target Neighborhood Hits	134	Shared Neighborhood Hits	53
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

HECD1_HUMAN
NC score	0.053688 (rank : 183)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	260	Target Neighborhood Hits	371	Shared Neighborhood Hits	28
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

MYPT1_HUMAN
NC score	0.053248 (rank : 184)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	260	Target Neighborhood Hits	723	Shared Neighborhood Hits	44
SwissProt Accessions	O14974, Q86WU3, Q8NFR6, Q9BYH0	Gene names	PPP1R12A, MBS, MYPT1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit).

ANKR2_HUMAN
NC score	0.053189 (rank : 185)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	260	Target Neighborhood Hits	321	Shared Neighborhood Hits	26
SwissProt Accessions	Q9GZV1, Q5T456, Q8WUD7	Gene names	ANKRD2, ARPP
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp).

PKHB1_MOUSE
NC score	0.053176 (rank : 186)	θ value	0.813845 (rank : 147)
Query Neighborhood Hits	260	Target Neighborhood Hits	47	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

FGD6_HUMAN
NC score	0.053073 (rank : 187)	θ value	0.813845 (rank : 146)
Query Neighborhood Hits	260	Target Neighborhood Hits	237	Shared Neighborhood Hits	45
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

ANR10_HUMAN
NC score	0.052994 (rank : 188)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	260	Target Neighborhood Hits	289	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NXR5	Gene names	ANKRD10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

FGD1_HUMAN
NC score	0.052821 (rank : 189)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	260	Target Neighborhood Hits	367	Shared Neighborhood Hits	46
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ASB10_HUMAN
NC score	0.052766 (rank : 190)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	260	Target Neighborhood Hits	291	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WXI3	Gene names	ASB10
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

CNKR2_MOUSE
NC score	0.052436 (rank : 191)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	260	Target Neighborhood Hits	197	Shared Neighborhood Hits	51
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

ANKR6_HUMAN
NC score	0.052361 (rank : 192)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	260	Target Neighborhood Hits	439	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y2G4, Q9NU24, Q9UFQ9	Gene names	ANKRD6, KIAA0957
Domain Architecture
Description	Ankyrin repeat domain-containing protein 6.

MYPT1_MOUSE
NC score	0.052319 (rank : 193)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	260	Target Neighborhood Hits	539	Shared Neighborhood Hits	31
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

CNKR2_HUMAN
NC score	0.052111 (rank : 194)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	260	Target Neighborhood Hits	197	Shared Neighborhood Hits	52
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

ANR42_HUMAN
NC score	0.052034 (rank : 195)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	260	Target Neighborhood Hits	284	Shared Neighborhood Hits	26
SwissProt Accessions	Q8N9B4, Q49A49	Gene names	ANKRD42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

CYH4_HUMAN
NC score	0.051944 (rank : 196)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	260	Target Neighborhood Hits	135	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

USH1G_MOUSE
NC score	0.051857 (rank : 197)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	260	Target Neighborhood Hits	271	Shared Neighborhood Hits	26
SwissProt Accessions	Q80T11, Q80UG0	Gene names	Ush1g, Sans
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein homolog (Scaffold protein containing ankyrin repeats and SAM domain) (Jackson shaker protein).

USH1G_HUMAN
NC score	0.051647 (rank : 198)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	260	Target Neighborhood Hits	267	Shared Neighborhood Hits	26
SwissProt Accessions	Q495M9, Q8N251	Gene names	USH1G, SANS
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein (Scaffold protein containing ankyrin repeats and SAM domain).

RAI14_MOUSE
NC score	0.051356 (rank : 199)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	260	Target Neighborhood Hits	1505	Shared Neighborhood Hits	69
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

ANK1_MOUSE
NC score	0.050945 (rank : 200)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	260	Target Neighborhood Hits	430	Shared Neighborhood Hits	30
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

ANK1_HUMAN
NC score	0.050858 (rank : 201)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	260	Target Neighborhood Hits	416	Shared Neighborhood Hits	27
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

FGD1_MOUSE
NC score	0.050726 (rank : 202)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	260	Target Neighborhood Hits	387	Shared Neighborhood Hits	45
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ANR10_MOUSE
NC score	0.050677 (rank : 203)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	260	Target Neighborhood Hits	273	Shared Neighborhood Hits	26
SwissProt Accessions	Q99LW0	Gene names	Ankrd10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

PSD10_HUMAN
NC score	0.050631 (rank : 204)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	260	Target Neighborhood Hits	301	Shared Neighborhood Hits	26
SwissProt Accessions	O75832	Gene names	PSMD10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

ASB10_MOUSE
NC score	0.050547 (rank : 205)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	260	Target Neighborhood Hits	301	Shared Neighborhood Hits	26
SwissProt Accessions	Q91ZT7	Gene names	Asb10
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

GRP3_HUMAN
NC score	0.050410 (rank : 206)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	260	Target Neighborhood Hits	131	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

ANR52_HUMAN
NC score	0.050040 (rank : 207)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	260	Target Neighborhood Hits	322	Shared Neighborhood Hits	26
SwissProt Accessions	Q8NB46	Gene names	ANKRD52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ANR52_MOUSE
NC score	0.050030 (rank : 208)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	260	Target Neighborhood Hits	318	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BTI7	Gene names	Ankrd52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ANKS1_MOUSE
NC score	0.049770 (rank : 209)	θ value	4.03905 (rank : 195)
Query Neighborhood Hits	260	Target Neighborhood Hits	453	Shared Neighborhood Hits	57
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

FGD4_HUMAN
NC score	0.049601 (rank : 210)	θ value	1.38821 (rank : 162)
Query Neighborhood Hits	260	Target Neighborhood Hits	219	Shared Neighborhood Hits	45
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

OSBP2_MOUSE
NC score	0.048995 (rank : 211)	θ value	8.99809 (rank : 255)
Query Neighborhood Hits	260	Target Neighborhood Hits	150	Shared Neighborhood Hits	43
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

FARP2_HUMAN
NC score	0.048986 (rank : 212)	θ value	3.0926 (rank : 184)
Query Neighborhood Hits	260	Target Neighborhood Hits	240	Shared Neighborhood Hits	39
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FGD6_MOUSE
NC score	0.048819 (rank : 213)	θ value	1.06291 (rank : 151)
Query Neighborhood Hits	260	Target Neighborhood Hits	282	Shared Neighborhood Hits	37
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

PKHB1_HUMAN
NC score	0.047742 (rank : 214)	θ value	1.81305 (rank : 169)
Query Neighborhood Hits	260	Target Neighborhood Hits	46	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

EPHB6_HUMAN
NC score	0.047421 (rank : 215)	θ value	0.0736092 (rank : 108)
Query Neighborhood Hits	260	Target Neighborhood Hits	912	Shared Neighborhood Hits	41
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

EPHB6_MOUSE
NC score	0.046812 (rank : 216)	θ value	0.0961366 (rank : 114)
Query Neighborhood Hits	260	Target Neighborhood Hits	906	Shared Neighborhood Hits	39
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

FARP2_MOUSE
NC score	0.045184 (rank : 217)	θ value	3.0926 (rank : 185)
Query Neighborhood Hits	260	Target Neighborhood Hits	209	Shared Neighborhood Hits	42
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

EPHA1_MOUSE
NC score	0.043628 (rank : 218)	θ value	0.00102713 (rank : 87)
Query Neighborhood Hits	260	Target Neighborhood Hits	958	Shared Neighborhood Hits	39
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHA1_HUMAN
NC score	0.042248 (rank : 219)	θ value	0.00390308 (rank : 91)
Query Neighborhood Hits	260	Target Neighborhood Hits	997	Shared Neighborhood Hits	39
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHA4_HUMAN
NC score	0.042229 (rank : 220)	θ value	0.0148317 (rank : 94)
Query Neighborhood Hits	260	Target Neighborhood Hits	975	Shared Neighborhood Hits	40
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA6_HUMAN
NC score	0.041687 (rank : 221)	θ value	0.47712 (rank : 135)
Query Neighborhood Hits	260	Target Neighborhood Hits	959	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA4_MOUSE
NC score	0.040588 (rank : 222)	θ value	0.0961366 (rank : 113)
Query Neighborhood Hits	260	Target Neighborhood Hits	982	Shared Neighborhood Hits	41
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA6_MOUSE
NC score	0.040444 (rank : 223)	θ value	0.21417 (rank : 125)
Query Neighborhood Hits	260	Target Neighborhood Hits	946	Shared Neighborhood Hits	40
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

SAMN1_HUMAN
NC score	0.039726 (rank : 224)	θ value	1.81305 (rank : 170)
Query Neighborhood Hits	260	Target Neighborhood Hits	74	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

EPHA8_MOUSE
NC score	0.038881 (rank : 225)	θ value	1.06291 (rank : 150)
Query Neighborhood Hits	260	Target Neighborhood Hits	969	Shared Neighborhood Hits	40
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHA2_MOUSE
NC score	0.037590 (rank : 226)	θ value	0.125558 (rank : 118)
Query Neighborhood Hits	260	Target Neighborhood Hits	1020	Shared Neighborhood Hits	41
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHA8_HUMAN
NC score	0.037325 (rank : 227)	θ value	1.06291 (rank : 149)
Query Neighborhood Hits	260	Target Neighborhood Hits	956	Shared Neighborhood Hits	40
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

ANLN_MOUSE
NC score	0.037182 (rank : 228)	θ value	3.0926 (rank : 182)
Query Neighborhood Hits	260	Target Neighborhood Hits	297	Shared Neighborhood Hits	28
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

EPHA2_HUMAN
NC score	0.037123 (rank : 229)	θ value	0.125558 (rank : 117)
Query Neighborhood Hits	260	Target Neighborhood Hits	1021	Shared Neighborhood Hits	41
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

STAP2_MOUSE
NC score	0.036789 (rank : 230)	θ value	1.81305 (rank : 171)
Query Neighborhood Hits	260	Target Neighborhood Hits	41	Shared Neighborhood Hits	8
SwissProt Accessions	Q8R0L1, Q8BWS2	Gene names	Stap2
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 2 (STAP-2).

EPHA7_HUMAN
NC score	0.036526 (rank : 231)	θ value	1.38821 (rank : 159)
Query Neighborhood Hits	260	Target Neighborhood Hits	1053	Shared Neighborhood Hits	40
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA5_HUMAN
NC score	0.036366 (rank : 232)	θ value	5.27518 (rank : 213)
Query Neighborhood Hits	260	Target Neighborhood Hits	1009	Shared Neighborhood Hits	42
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHB1_HUMAN
NC score	0.036288 (rank : 233)	θ value	0.279714 (rank : 129)
Query Neighborhood Hits	260	Target Neighborhood Hits	988	Shared Neighborhood Hits	40
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

EPHA7_MOUSE
NC score	0.035977 (rank : 234)	θ value	1.38821 (rank : 160)
Query Neighborhood Hits	260	Target Neighborhood Hits	1025	Shared Neighborhood Hits	39
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHB2_HUMAN
NC score	0.035848 (rank : 235)	θ value	1.38821 (rank : 161)
Query Neighborhood Hits	260	Target Neighborhood Hits	983	Shared Neighborhood Hits	39
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
NC score	0.035277 (rank : 236)	θ value	4.03905 (rank : 198)
Query Neighborhood Hits	260	Target Neighborhood Hits	982	Shared Neighborhood Hits	39
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB4_MOUSE
NC score	0.032395 (rank : 237)	θ value	5.27518 (rank : 214)
Query Neighborhood Hits	260	Target Neighborhood Hits	1013	Shared Neighborhood Hits	40
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHB4_HUMAN
NC score	0.031825 (rank : 238)	θ value	6.88961 (rank : 231)
Query Neighborhood Hits	260	Target Neighborhood Hits	1056	Shared Neighborhood Hits	40
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

SAMN1_MOUSE
NC score	0.031061 (rank : 239)	θ value	6.88961 (rank : 240)
Query Neighborhood Hits	260	Target Neighborhood Hits	69	Shared Neighborhood Hits	14
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

PKHF2_MOUSE
NC score	0.030277 (rank : 240)	θ value	4.03905 (rank : 202)
Query Neighborhood Hits	260	Target Neighborhood Hits	77	Shared Neighborhood Hits	18
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHF2_HUMAN
NC score	0.029694 (rank : 241)	θ value	5.27518 (rank : 217)
Query Neighborhood Hits	260	Target Neighborhood Hits	75	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF1_MOUSE
NC score	0.029061 (rank : 242)	θ value	8.99809 (rank : 256)
Query Neighborhood Hits	260	Target Neighborhood Hits	80	Shared Neighborhood Hits	18
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

XPO7_MOUSE
NC score	0.027278 (rank : 243)	θ value	0.47712 (rank : 137)
Query Neighborhood Hits	260	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EPK7, Q3TP94, Q80TS9, Q8BSK5, Q8C9M7, Q8CB42, Q8CBL8, Q8CEF5	Gene names	Xpo7, Kiaa0745, Ranbp16
Domain Architecture
Description	Exportin-7 (Exp7) (Ran-binding protein 16).

XPO7_HUMAN
NC score	0.027249 (rank : 244)	θ value	0.47712 (rank : 136)
Query Neighborhood Hits	260	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UIA9, O94846, Q6PJK9, Q8NEK7	Gene names	XPO7, KIAA0745, RANBP16
Domain Architecture
Description	Exportin-7 (Exp7) (Ran-binding protein 16).

PPR3A_HUMAN
NC score	0.025849 (rank : 245)	θ value	0.279714 (rank : 130)
Query Neighborhood Hits	260	Target Neighborhood Hits	54	Shared Neighborhood Hits	2
SwissProt Accessions	Q16821, O43476, Q75LN8, Q7KYM8, Q86UI6	Gene names	PPP1R3A, PP1G
Domain Architecture	No domain graphic available
Description	Protein phosphatase 1 regulatory subunit 3A (Protein phosphatase 1 glycogen-associated regulatory subunit) (Protein phosphatase type-1 glycogen targeting subunit).

SMC1A_HUMAN
NC score	0.024376 (rank : 246)	θ value	0.0736092 (rank : 110)
Query Neighborhood Hits	260	Target Neighborhood Hits	1346	Shared Neighborhood Hits	42
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

TEC_MOUSE
NC score	0.024005 (rank : 247)	θ value	2.36792 (rank : 181)
Query Neighborhood Hits	260	Target Neighborhood Hits	1006	Shared Neighborhood Hits	57
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

SMC1A_MOUSE
NC score	0.024005 (rank : 248)	θ value	0.0736092 (rank : 111)
Query Neighborhood Hits	260	Target Neighborhood Hits	1384	Shared Neighborhood Hits	45
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

CLCN1_HUMAN
NC score	0.023890 (rank : 249)	θ value	0.163984 (rank : 121)
Query Neighborhood Hits	260	Target Neighborhood Hits	89	Shared Neighborhood Hits	6
SwissProt Accessions	P35523	Gene names	CLCN1, CLC1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

NIN_HUMAN
NC score	0.023276 (rank : 250)	θ value	0.365318 (rank : 133)
Query Neighborhood Hits	260	Target Neighborhood Hits	1416	Shared Neighborhood Hits	50
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

SOS1_HUMAN
NC score	0.022266 (rank : 251)	θ value	3.0926 (rank : 194)
Query Neighborhood Hits	260	Target Neighborhood Hits	274	Shared Neighborhood Hits	16
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

CP250_MOUSE
NC score	0.021817 (rank : 252)	θ value	0.0563607 (rank : 105)
Query Neighborhood Hits	260	Target Neighborhood Hits	1583	Shared Neighborhood Hits	58
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

SOS2_HUMAN
NC score	0.021641 (rank : 253)	θ value	2.36792 (rank : 179)
Query Neighborhood Hits	260	Target Neighborhood Hits	193	Shared Neighborhood Hits	14
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

GCC2_HUMAN
NC score	0.021545 (rank : 254)	θ value	4.03905 (rank : 200)
Query Neighborhood Hits	260	Target Neighborhood Hits	1558	Shared Neighborhood Hits	58
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

MADCA_MOUSE
NC score	0.021519 (rank : 255)	θ value	1.38821 (rank : 163)
Query Neighborhood Hits	260	Target Neighborhood Hits	56	Shared Neighborhood Hits	4
SwissProt Accessions	Q61826, O35530, Q61278, Q64275, Q8R1M6	Gene names	Madcam1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (mMAdCAM-1).

STAP2_HUMAN
NC score	0.021513 (rank : 256)	θ value	5.27518 (rank : 219)
Query Neighborhood Hits	260	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UGK3, Q9NXI2	Gene names	STAP2, BKS
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 2 (STAP-2) (Breast tumor kinase substrate) (BRK substrate).

RBP24_HUMAN
NC score	0.021398 (rank : 257)	θ value	4.03905 (rank : 203)
Query Neighborhood Hits	260	Target Neighborhood Hits	1559	Shared Neighborhood Hits	57
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

DPOG1_MOUSE
NC score	0.020866 (rank : 258)	θ value	0.813845 (rank : 145)
Query Neighborhood Hits	260	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	P54099, Q9JI28	Gene names	Polg, Polg1
Domain Architecture
Description	DNA polymerase subunit gamma 1 (EC 2.7.7.7) (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha).

CNOT2_MOUSE
NC score	0.020783 (rank : 259)	θ value	2.36792 (rank : 174)
Query Neighborhood Hits	260	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C5L3, Q3UE39, Q80YA5, Q9D0P1	Gene names	Cnot2
Domain Architecture
Description	CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2).

CI084_HUMAN
NC score	0.020506 (rank : 260)	θ value	8.99809 (rank : 244)
Query Neighborhood Hits	260	Target Neighborhood Hits	40	Shared Neighborhood Hits	5
SwissProt Accessions	Q5VXU9, Q96M73	Gene names	C9orf84
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf84.

CNOT2_HUMAN
NC score	0.019668 (rank : 261)	θ value	3.0926 (rank : 183)
Query Neighborhood Hits	260	Target Neighborhood Hits	51	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZN8, Q9H3E0, Q9NSX5, Q9NWR6, Q9P028	Gene names	CNOT2, CDC36, NOT2
Domain Architecture
Description	CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2).

CENPE_HUMAN
NC score	0.019431 (rank : 262)	θ value	1.38821 (rank : 157)
Query Neighborhood Hits	260	Target Neighborhood Hits	2060	Shared Neighborhood Hits	64
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

CIR_HUMAN
NC score	0.018560 (rank : 263)	θ value	1.38821 (rank : 158)
Query Neighborhood Hits	260	Target Neighborhood Hits	249	Shared Neighborhood Hits	12
SwissProt Accessions	Q86X95, O95367, Q12804, Q4G1B9, Q6PJI4, Q8IWI2	Gene names	CIR
Domain Architecture	No domain graphic available
Description	CBF1-interacting corepressor (Recepin).

RPGR1_MOUSE
NC score	0.018557 (rank : 264)	θ value	4.03905 (rank : 204)
Query Neighborhood Hits	260	Target Neighborhood Hits	713	Shared Neighborhood Hits	32
SwissProt Accessions	Q9EPQ2, Q8CAC2, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1	Gene names	Rpgrip1
Domain Architecture	No domain graphic available
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

SOS1_MOUSE
NC score	0.018460 (rank : 265)	θ value	2.36792 (rank : 178)
Query Neighborhood Hits	260	Target Neighborhood Hits	281	Shared Neighborhood Hits	15
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

DESP_HUMAN
NC score	0.018435 (rank : 266)	θ value	0.813845 (rank : 143)
Query Neighborhood Hits	260	Target Neighborhood Hits	1470	Shared Neighborhood Hits	49
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

SKI_HUMAN
NC score	0.018385 (rank : 267)	θ value	1.06291 (rank : 154)
Query Neighborhood Hits	260	Target Neighborhood Hits	423	Shared Neighborhood Hits	23
SwissProt Accessions	P12755, Q5SYT7	Gene names	SKI
Domain Architecture
Description	Ski oncogene (C-ski).

OSTP_HUMAN
NC score	0.017459 (rank : 268)	θ value	3.0926 (rank : 190)
Query Neighborhood Hits	260	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	P10451, Q15681, Q15682, Q15683, Q8NBK2, Q96IZ1	Gene names	SPP1, OPN
Domain Architecture
Description	Osteopontin precursor (Bone sialoprotein-1) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Nephropontin) (Uropontin).

RB39B_MOUSE
NC score	0.016629 (rank : 269)	θ value	3.0926 (rank : 193)
Query Neighborhood Hits	260	Target Neighborhood Hits	277	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BHC1, Q3TUJ3	Gene names	Rab39b
Domain Architecture
Description	Ras-related protein Rab-39B.

RB39B_HUMAN
NC score	0.016604 (rank : 270)	θ value	3.0926 (rank : 192)
Query Neighborhood Hits	260	Target Neighborhood Hits	279	Shared Neighborhood Hits	15
SwissProt Accessions	Q96DA2, Q5JT79, Q8NEX3	Gene names	RAB39B
Domain Architecture
Description	Ras-related protein Rab-39B.

ALS2_HUMAN
NC score	0.016430 (rank : 271)	θ value	8.99809 (rank : 241)
Query Neighborhood Hits	260	Target Neighborhood Hits	121	Shared Neighborhood Hits	20
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

RBCC1_MOUSE
NC score	0.016337 (rank : 272)	θ value	1.06291 (rank : 153)
Query Neighborhood Hits	260	Target Neighborhood Hits	1048	Shared Neighborhood Hits	40
SwissProt Accessions	Q9ESK9, Q3TXX2, Q61384, Q8BRY9, Q9JK14	Gene names	Rb1cc1, Cc1, Kiaa0203
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (LaXp180 protein).

KTN1_HUMAN
NC score	0.016064 (rank : 273)	θ value	1.81305 (rank : 166)
Query Neighborhood Hits	260	Target Neighborhood Hits	1197	Shared Neighborhood Hits	43
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

GOGA5_HUMAN
NC score	0.015998 (rank : 274)	θ value	6.88961 (rank : 232)
Query Neighborhood Hits	260	Target Neighborhood Hits	1168	Shared Neighborhood Hits	51
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

ALS2_MOUSE
NC score	0.015470 (rank : 275)	θ value	8.99809 (rank : 242)
Query Neighborhood Hits	260	Target Neighborhood Hits	111	Shared Neighborhood Hits	16
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

SKI_MOUSE
NC score	0.014753 (rank : 276)	θ value	4.03905 (rank : 205)
Query Neighborhood Hits	260	Target Neighborhood Hits	423	Shared Neighborhood Hits	20
SwissProt Accessions	Q60698, Q8VIL5	Gene names	Ski
Domain Architecture	No domain graphic available
Description	Ski oncogene (C-ski).

SVIL_MOUSE
NC score	0.014723 (rank : 277)	θ value	2.36792 (rank : 180)
Query Neighborhood Hits	260	Target Neighborhood Hits	439	Shared Neighborhood Hits	23
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

INSRR_MOUSE
NC score	0.014660 (rank : 278)	θ value	6.88961 (rank : 233)
Query Neighborhood Hits	260	Target Neighborhood Hits	961	Shared Neighborhood Hits	27
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

CLCN1_MOUSE
NC score	0.014286 (rank : 279)	θ value	5.27518 (rank : 211)
Query Neighborhood Hits	260	Target Neighborhood Hits	61	Shared Neighborhood Hits	4
SwissProt Accessions	Q64347	Gene names	Clcn1, Clc1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

CENPU_MOUSE
NC score	0.014041 (rank : 280)	θ value	6.88961 (rank : 223)
Query Neighborhood Hits	260	Target Neighborhood Hits	137	Shared Neighborhood Hits	10
SwissProt Accessions	Q8C4M7, Q6UNA2, Q9D9U1	Gene names	Mlf1ip, Cenpu
Domain Architecture	No domain graphic available
Description	Centromere protein U (CENP-U) (MLF1-interacting protein).

PAPOG_HUMAN
NC score	0.013935 (rank : 281)	θ value	2.36792 (rank : 176)
Query Neighborhood Hits	260	Target Neighborhood Hits	44	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BWT3, Q969N1, Q9H8L2, Q9HAD0	Gene names	PAPOLG, PAP2, PAPG
Domain Architecture
Description	Poly(A) polymerase gamma (EC 2.7.7.19) (PAP gamma) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3' adenylating enzyme) (Neo- poly(A) polymerase) (Neo-PAP).

PAPOG_MOUSE
NC score	0.013921 (rank : 282)	θ value	1.81305 (rank : 168)
Query Neighborhood Hits	260	Target Neighborhood Hits	103	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PCL9, Q8BZC9	Gene names	Papolg
Domain Architecture	No domain graphic available
Description	Poly(A) polymerase gamma (EC 2.7.7.19) (PAP gamma) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3' adenylating enzyme).

FBX4_MOUSE
NC score	0.013867 (rank : 283)	θ value	3.0926 (rank : 186)
Query Neighborhood Hits	260	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CHQ0, Q99JG8	Gene names	Fbxo4, Fbx4
Domain Architecture	No domain graphic available
Description	F-box only protein 4.

SPC25_MOUSE
NC score	0.013755 (rank : 284)	θ value	8.99809 (rank : 260)
Query Neighborhood Hits	260	Target Neighborhood Hits	241	Shared Neighborhood Hits	19
SwissProt Accessions	Q3UA16, Q9D021, Q9D1K6	Gene names	Spbc25
Domain Architecture	No domain graphic available
Description	Kinetochore protein Spc25.

TRHY_HUMAN
NC score	0.013119 (rank : 285)	θ value	1.06291 (rank : 155)
Query Neighborhood Hits	260	Target Neighborhood Hits	1385	Shared Neighborhood Hits	40
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

IL9R_MOUSE
NC score	0.012991 (rank : 286)	θ value	3.0926 (rank : 187)
Query Neighborhood Hits	260	Target Neighborhood Hits	38	Shared Neighborhood Hits	2
SwissProt Accessions	Q01114	Gene names	Il9r
Domain Architecture	No domain graphic available
Description	Interleukin-9 receptor precursor (IL-9R) (CD129 antigen).

MUT_MOUSE
NC score	0.012130 (rank : 287)	θ value	6.88961 (rank : 236)
Query Neighborhood Hits	260	Target Neighborhood Hits	52	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R015, Q3TCP2, Q8CAC9	Gene names	Muted, Mu
Domain Architecture	No domain graphic available
Description	Muted protein.

RB39A_HUMAN
NC score	0.012022 (rank : 288)	θ value	5.27518 (rank : 218)
Query Neighborhood Hits	260	Target Neighborhood Hits	276	Shared Neighborhood Hits	15
SwissProt Accessions	Q14964, Q8N6W2	Gene names	RAB39, RAB39A
Domain Architecture
Description	Ras-related protein Rab-39A (Rab-39).

ELL_MOUSE
NC score	0.011275 (rank : 289)	θ value	4.03905 (rank : 197)
Query Neighborhood Hits	260	Target Neighborhood Hits	115	Shared Neighborhood Hits	6
SwissProt Accessions	O08856	Gene names	Ell
Domain Architecture
Description	RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein).

ZC313_HUMAN
NC score	0.011263 (rank : 290)	θ value	4.03905 (rank : 210)
Query Neighborhood Hits	260	Target Neighborhood Hits	772	Shared Neighborhood Hits	22
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

RFC1_HUMAN
NC score	0.011072 (rank : 291)	θ value	2.36792 (rank : 177)
Query Neighborhood Hits	260	Target Neighborhood Hits	352	Shared Neighborhood Hits	10
SwissProt Accessions	P35251, Q5XKF5, Q6PKU0, Q86V41, Q86V46	Gene names	RFC1, RFC140
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (DNA-binding protein PO-GA).

RB39A_MOUSE
NC score	0.010388 (rank : 292)	θ value	8.99809 (rank : 257)
Query Neighborhood Hits	260	Target Neighborhood Hits	279	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BHD0	Gene names	Rab39, Rab39a
Domain Architecture
Description	Ras-related protein Rab-39A (Rab-39).

RIF1_MOUSE
NC score	0.009555 (rank : 293)	θ value	6.88961 (rank : 239)
Query Neighborhood Hits	260	Target Neighborhood Hits	315	Shared Neighborhood Hits	15
SwissProt Accessions	Q6PR54, Q6T8D9, Q7TPD8, Q8BTU2, Q8C408, Q9CS77	Gene names	Rif1
Domain Architecture	No domain graphic available
Description	Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) (mRif1).

MACF4_HUMAN
NC score	0.009478 (rank : 294)	θ value	6.88961 (rank : 235)
Query Neighborhood Hits	260	Target Neighborhood Hits	1321	Shared Neighborhood Hits	43
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

KIF1B_HUMAN
NC score	0.009136 (rank : 295)	θ value	5.27518 (rank : 215)
Query Neighborhood Hits	260	Target Neighborhood Hits	178	Shared Neighborhood Hits	19
SwissProt Accessions	O60333, Q96Q94, Q9BV80, Q9P280	Gene names	KIF1B, KIAA0591, KIAA1448
Domain Architecture
Description	Kinesin-like protein KIF1B (Klp).

DOK4_MOUSE
NC score	0.008818 (rank : 296)	θ value	6.88961 (rank : 229)
Query Neighborhood Hits	260	Target Neighborhood Hits	30	Shared Neighborhood Hits	5
SwissProt Accessions	Q99KE3, Q3U0X3	Gene names	Dok4
Domain Architecture	No domain graphic available
Description	Docking protein 4 (Downstream of tyrosine kinase 4).

DOK4_HUMAN
NC score	0.008809 (rank : 297)	θ value	6.88961 (rank : 228)
Query Neighborhood Hits	260	Target Neighborhood Hits	28	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TEW6, O75209, Q9BTP2, Q9NVV3	Gene names	DOK4
Domain Architecture	No domain graphic available
Description	Docking protein 4 (Downstream of tyrosine kinase 4).

KIF1B_MOUSE
NC score	0.008801 (rank : 298)	θ value	8.99809 (rank : 249)
Query Neighborhood Hits	260	Target Neighborhood Hits	167	Shared Neighborhood Hits	17
SwissProt Accessions	Q60575, Q9R0B4, Q9WVE5, Q9Z119	Gene names	Kif1b
Domain Architecture
Description	Kinesin-like protein KIF1B.

OXR1_MOUSE
NC score	0.008275 (rank : 299)	θ value	3.0926 (rank : 191)
Query Neighborhood Hits	260	Target Neighborhood Hits	516	Shared Neighborhood Hits	15
SwissProt Accessions	Q4KMM3, Q5FWW1, Q99L06, Q99MK1, Q99MP4	Gene names	Oxr1, C7
Domain Architecture	No domain graphic available
Description	Oxidation resistance protein 1 (Protein C7).

DYNA_HUMAN
NC score	0.008097 (rank : 300)	θ value	8.99809 (rank : 246)
Query Neighborhood Hits	260	Target Neighborhood Hits	1194	Shared Neighborhood Hits	33
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

SLK_MOUSE
NC score	0.007752 (rank : 301)	θ value	4.03905 (rank : 207)
Query Neighborhood Hits	260	Target Neighborhood Hits	1798	Shared Neighborhood Hits	66
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

LC7L2_MOUSE
NC score	0.007722 (rank : 302)	θ value	8.99809 (rank : 251)
Query Neighborhood Hits	260	Target Neighborhood Hits	244	Shared Neighborhood Hits	16
SwissProt Accessions	Q7TNC4, Q99LM5, Q99PC3	Gene names	Luc7l2
Domain Architecture
Description	Putative RNA-binding protein Luc7-like 2 (CGI-74 homolog).

DYNA_MOUSE
NC score	0.007488 (rank : 303)	θ value	8.99809 (rank : 247)
Query Neighborhood Hits	260	Target Neighborhood Hits	1084	Shared Neighborhood Hits	32
SwissProt Accessions	O08788	Gene names	Dctn1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued).

LC7L2_HUMAN
NC score	0.007432 (rank : 304)	θ value	8.99809 (rank : 250)
Query Neighborhood Hits	260	Target Neighborhood Hits	235	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y383, Q8IUP9, Q9NVL3, Q9NVN7, Q9UQN1	Gene names	LUC7L2
Domain Architecture
Description	Putative RNA-binding protein Luc7-like 2.

METL4_HUMAN
NC score	0.007322 (rank : 305)	θ value	8.99809 (rank : 253)
Query Neighborhood Hits	260	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N3J2, Q2TAA7, Q9H5U9	Gene names	METTL4
Domain Architecture	No domain graphic available
Description	Methyltransferase-like protein 4 (EC 2.1.1.-).

SYTL4_HUMAN
NC score	0.007190 (rank : 306)	θ value	5.27518 (rank : 220)
Query Neighborhood Hits	260	Target Neighborhood Hits	138	Shared Neighborhood Hits	9
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SLK_HUMAN
NC score	0.007042 (rank : 307)	θ value	4.03905 (rank : 206)
Query Neighborhood Hits	260	Target Neighborhood Hits	1775	Shared Neighborhood Hits	66
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

DYH11_HUMAN
NC score	0.006950 (rank : 308)	θ value	6.88961 (rank : 230)
Query Neighborhood Hits	260	Target Neighborhood Hits	234	Shared Neighborhood Hits	15
SwissProt Accessions	Q96DT5, Q9UJ82	Gene names	DNAH11
Domain Architecture
Description	Ciliary dynein heavy chain 11 (Axonemal beta dynein heavy chain 11).

ACINU_HUMAN
NC score	0.006731 (rank : 309)	θ value	6.88961 (rank : 221)
Query Neighborhood Hits	260	Target Neighborhood Hits	828	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

KIF3B_HUMAN
NC score	0.006031 (rank : 310)	θ value	5.27518 (rank : 216)
Query Neighborhood Hits	260	Target Neighborhood Hits	540	Shared Neighborhood Hits	28
SwissProt Accessions	O15066	Gene names	KIF3B, KIAA0359
Domain Architecture
Description	Kinesin-like protein KIF3B (Microtubule plus end-directed kinesin motor 3B) (HH0048).

AP3B1_HUMAN
NC score	0.005913 (rank : 311)	θ value	4.03905 (rank : 196)
Query Neighborhood Hits	260	Target Neighborhood Hits	283	Shared Neighborhood Hits	8
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

CHD2_HUMAN
NC score	0.005567 (rank : 312)	θ value	6.88961 (rank : 224)
Query Neighborhood Hits	260	Target Neighborhood Hits	360	Shared Neighborhood Hits	14
SwissProt Accessions	O14647	Gene names	CHD2
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 2 (EC 3.6.1.-) (ATP- dependent helicase CHD2) (CHD-2).

FILA_HUMAN
NC score	0.005565 (rank : 313)	θ value	8.99809 (rank : 248)
Query Neighborhood Hits	260	Target Neighborhood Hits	685	Shared Neighborhood Hits	20
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

TSH3_HUMAN
NC score	0.004302 (rank : 314)	θ value	4.03905 (rank : 208)
Query Neighborhood Hits	260	Target Neighborhood Hits	564	Shared Neighborhood Hits	4
SwissProt Accessions	Q63HK5, Q9H0G6, Q9P254	Gene names	TSHZ3, KIAA1474, TSH3, ZNF537
Domain Architecture	No domain graphic available
Description	Teashirt homolog 3 (Zinc finger protein 537).

ULK2_HUMAN
NC score	0.003910 (rank : 315)	θ value	4.03905 (rank : 209)
Query Neighborhood Hits	260	Target Neighborhood Hits	979	Shared Neighborhood Hits	30
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

BBX_MOUSE
NC score	0.003660 (rank : 316)	θ value	6.88961 (rank : 222)
Query Neighborhood Hits	260	Target Neighborhood Hits	152	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VBW5, Q3TZK1, Q6NXY8, Q6PEU3, Q8BQJ7, Q8C7E0, Q8CDQ0, Q8CDV1, Q8VI48, Q8VI49, Q8VI50, Q9CS94	Gene names	Bbx, Hbp2
Domain Architecture	No domain graphic available
Description	HMG box transcription factor BBX (Bobby sox homolog) (HMG box- containing protein 2).

AP3D1_MOUSE
NC score	0.003390 (rank : 317)	θ value	8.99809 (rank : 243)
Query Neighborhood Hits	260	Target Neighborhood Hits	144	Shared Neighborhood Hits	5
SwissProt Accessions	O54774	Gene names	Ap3d1, Ap3d
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin) (mBLVR1).

RAB8A_MOUSE
NC score	0.003244 (rank : 318)	θ value	6.88961 (rank : 238)
Query Neighborhood Hits	260	Target Neighborhood Hits	269	Shared Neighborhood Hits	9
SwissProt Accessions	P55258, Q8VCF6	Gene names	Rab8a, Mel, Rab8
Domain Architecture
Description	Ras-related protein Rab-8A (Oncogene c-mel).

RAB8A_HUMAN
NC score	0.003232 (rank : 319)	θ value	6.88961 (rank : 237)
Query Neighborhood Hits	260	Target Neighborhood Hits	269	Shared Neighborhood Hits	9
SwissProt Accessions	P61006, P24407	Gene names	RAB8A, MEL, RAB8
Domain Architecture
Description	Ras-related protein Rab-8A (Oncogene c-mel).

ATS12_HUMAN
NC score	0.001497 (rank : 320)	θ value	2.36792 (rank : 172)
Query Neighborhood Hits	260	Target Neighborhood Hits	251	Shared Neighborhood Hits	4
SwissProt Accessions	P58397, Q6UWL3	Gene names	ADAMTS12
Domain Architecture
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

RBBP7_HUMAN
NC score	-0.000312 (rank : 321)	θ value	8.99809 (rank : 258)
Query Neighborhood Hits	260	Target Neighborhood Hits	285	Shared Neighborhood Hits	3
SwissProt Accessions	Q16576	Gene names	RBBP7, RBAP46
Domain Architecture
Description	Histone-binding protein RBBP7 (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) (Histone acetyltransferase type B subunit 2) (Nucleosome remodeling factor subunit RBAP46).

RBBP7_MOUSE
NC score	-0.000318 (rank : 322)	θ value	8.99809 (rank : 259)
Query Neighborhood Hits	260	Target Neighborhood Hits	285	Shared Neighborhood Hits	3
SwissProt Accessions	Q60973, Q3UX20	Gene names	Rbbp7, Rbap46
Domain Architecture
Description	Histone-binding protein RBBP7 (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) (Histone acetyltransferase type B subunit 2) (Nucleosome remodeling factor subunit RBAP46).

MASTL_HUMAN
NC score	-0.000553 (rank : 323)	θ value	8.99809 (rank : 252)
Query Neighborhood Hits	260	Target Neighborhood Hits	894	Shared Neighborhood Hits	26
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

OPRM_HUMAN
NC score	-0.006579 (rank : 324)	θ value	3.0926 (rank : 189)
Query Neighborhood Hits	260	Target Neighborhood Hits	900	Shared Neighborhood Hits	2
SwissProt Accessions	P35372, Q12930, Q7Z2D8, Q9UCZ4, Q9UN57	Gene names	OPRM1, MOR1
Domain Architecture
Description	Mu-type opioid receptor (MOR-1).