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Network neighborhood for query Sequence : ANKS1_MOUSE

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ANKS1_MOUSE
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ANKS1_HUMAN
θ value	0 (rank : 1)	NC score	0.991857 (rank : 2)
Query Neighborhood Hits	453	Target Neighborhood Hits	438	Shared Neighborhood Hits	386
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

ANKS1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	453	Target Neighborhood Hits	453	Shared Neighborhood Hits	453
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

CSKI2_HUMAN
θ value	8.02596e-49 (rank : 3)	NC score	0.890022 (rank : 3)
Query Neighborhood Hits	453	Target Neighborhood Hits	747	Shared Neighborhood Hits	360
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CSKI2_MOUSE
θ value	1.04822e-48 (rank : 4)	NC score	0.889573 (rank : 4)
Query Neighborhood Hits	453	Target Neighborhood Hits	812	Shared Neighborhood Hits	348
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CSKI1_HUMAN
θ value	8.30557e-46 (rank : 5)	NC score	0.872711 (rank : 13)
Query Neighborhood Hits	453	Target Neighborhood Hits	997	Shared Neighborhood Hits	348
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI1_MOUSE
θ value	1.41672e-45 (rank : 6)	NC score	0.872490 (rank : 14)
Query Neighborhood Hits	453	Target Neighborhood Hits	1031	Shared Neighborhood Hits	351
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

ANK1_MOUSE
θ value	8.3442e-30 (rank : 7)	NC score	0.869599 (rank : 23)
Query Neighborhood Hits	453	Target Neighborhood Hits	430	Shared Neighborhood Hits	303
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

ANK1_HUMAN
θ value	1.33217e-27 (rank : 8)	NC score	0.870593 (rank : 20)
Query Neighborhood Hits	453	Target Neighborhood Hits	416	Shared Neighborhood Hits	301
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

ANK3_HUMAN
θ value	1.73987e-27 (rank : 9)	NC score	0.857301 (rank : 34)
Query Neighborhood Hits	453	Target Neighborhood Hits	853	Shared Neighborhood Hits	311
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

ANK2_HUMAN
θ value	1.92365e-26 (rank : 10)	NC score	0.804064 (rank : 107)
Query Neighborhood Hits	453	Target Neighborhood Hits	1615	Shared Neighborhood Hits	340
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

RIPK4_HUMAN
θ value	4.28545e-26 (rank : 11)	NC score	0.581843 (rank : 205)
Query Neighborhood Hits	453	Target Neighborhood Hits	1094	Shared Neighborhood Hits	328
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

ANR28_MOUSE
θ value	9.54697e-26 (rank : 12)	NC score	0.871497 (rank : 18)
Query Neighborhood Hits	453	Target Neighborhood Hits	314	Shared Neighborhood Hits	297
SwissProt Accessions	Q505D1	Gene names	Ankrd28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ANR28_HUMAN
θ value	3.62785e-25 (rank : 13)	NC score	0.870389 (rank : 21)
Query Neighborhood Hits	453	Target Neighborhood Hits	314	Shared Neighborhood Hits	295
SwissProt Accessions	O15084, Q6ULS0, Q6ZT57	Gene names	ANKRD28, KIAA0379
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ANKK1_HUMAN
θ value	8.08199e-25 (rank : 14)	NC score	0.585931 (rank : 202)
Query Neighborhood Hits	453	Target Neighborhood Hits	1075	Shared Neighborhood Hits	322
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

ANKK1_MOUSE
θ value	1.5242e-23 (rank : 15)	NC score	0.570867 (rank : 208)
Query Neighborhood Hits	453	Target Neighborhood Hits	1072	Shared Neighborhood Hits	321
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

ANR50_HUMAN
θ value	2.59989e-23 (rank : 16)	NC score	0.882093 (rank : 7)
Query Neighborhood Hits	453	Target Neighborhood Hits	361	Shared Neighborhood Hits	298
SwissProt Accessions	Q9ULJ7, Q6N064, Q6ZSE6	Gene names	ANKRD50, KIAA1223
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 50.

ANR44_HUMAN
θ value	5.79196e-23 (rank : 17)	NC score	0.871997 (rank : 15)
Query Neighborhood Hits	453	Target Neighborhood Hits	318	Shared Neighborhood Hits	298
SwissProt Accessions	Q8N8A2, Q6P480, Q86VL5, Q8IZ72, Q9UFA4	Gene names	ANKRD44
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 44.

ANR52_MOUSE
θ value	7.56453e-23 (rank : 18)	NC score	0.865275 (rank : 28)
Query Neighborhood Hits	453	Target Neighborhood Hits	318	Shared Neighborhood Hits	299
SwissProt Accessions	Q8BTI7	Gene names	Ankrd52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

INVS_MOUSE
θ value	7.56453e-23 (rank : 19)	NC score	0.863137 (rank : 31)
Query Neighborhood Hits	453	Target Neighborhood Hits	609	Shared Neighborhood Hits	303
SwissProt Accessions	O89019, O88849	Gene names	Invs, Inv, Nphp2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning protein) (Nephrocystin-2).

TNKS2_HUMAN
θ value	7.56453e-23 (rank : 20)	NC score	0.866442 (rank : 27)
Query Neighborhood Hits	453	Target Neighborhood Hits	361	Shared Neighborhood Hits	308
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

INVS_HUMAN
θ value	1.29031e-22 (rank : 21)	NC score	0.871560 (rank : 17)
Query Neighborhood Hits	453	Target Neighborhood Hits	455	Shared Neighborhood Hits	294
SwissProt Accessions	Q9Y283, Q5W0T6, Q8IVX8, Q9BRB9, Q9Y488, Q9Y498	Gene names	INVS, INV, NPHP2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning homolog) (Nephrocystin-2).

TNKS1_HUMAN
θ value	2.20094e-22 (rank : 22)	NC score	0.866712 (rank : 25)
Query Neighborhood Hits	453	Target Neighborhood Hits	477	Shared Neighborhood Hits	326
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

ANR52_HUMAN
θ value	2.87452e-22 (rank : 23)	NC score	0.864557 (rank : 29)
Query Neighborhood Hits	453	Target Neighborhood Hits	322	Shared Neighborhood Hits	299
SwissProt Accessions	Q8NB46	Gene names	ANKRD52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ANKR6_HUMAN
θ value	1.86321e-21 (rank : 24)	NC score	0.878206 (rank : 8)
Query Neighborhood Hits	453	Target Neighborhood Hits	439	Shared Neighborhood Hits	292
SwissProt Accessions	Q9Y2G4, Q9NU24, Q9UFQ9	Gene names	ANKRD6, KIAA0957
Domain Architecture
Description	Ankyrin repeat domain-containing protein 6.

TNI3K_HUMAN
θ value	1.86321e-21 (rank : 25)	NC score	0.470305 (rank : 237)
Query Neighborhood Hits	453	Target Neighborhood Hits	1084	Shared Neighborhood Hits	321
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNI3K_MOUSE
θ value	1.5773e-20 (rank : 26)	NC score	0.465502 (rank : 239)
Query Neighborhood Hits	453	Target Neighborhood Hits	1079	Shared Neighborhood Hits	321
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

DAPK1_HUMAN
θ value	2.69047e-20 (rank : 27)	NC score	0.404024 (rank : 261)
Query Neighborhood Hits	453	Target Neighborhood Hits	1130	Shared Neighborhood Hits	320
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

ASB3_MOUSE
θ value	4.58923e-20 (rank : 28)	NC score	0.877947 (rank : 9)
Query Neighborhood Hits	453	Target Neighborhood Hits	316	Shared Neighborhood Hits	294
SwissProt Accessions	Q9WV72	Gene names	Asb3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

DAPK1_MOUSE
θ value	3.88503e-19 (rank : 29)	NC score	0.411582 (rank : 256)
Query Neighborhood Hits	453	Target Neighborhood Hits	1138	Shared Neighborhood Hits	323
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

ASB3_HUMAN
θ value	5.07402e-19 (rank : 30)	NC score	0.875545 (rank : 11)
Query Neighborhood Hits	453	Target Neighborhood Hits	316	Shared Neighborhood Hits	296
SwissProt Accessions	Q9Y575, Q9NVZ2	Gene names	ASB3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

MIB1_HUMAN
θ value	5.07402e-19 (rank : 31)	NC score	0.830816 (rank : 59)
Query Neighborhood Hits	453	Target Neighborhood Hits	470	Shared Neighborhood Hits	295
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

MIB1_MOUSE
θ value	5.07402e-19 (rank : 32)	NC score	0.830377 (rank : 60)
Query Neighborhood Hits	453	Target Neighborhood Hits	471	Shared Neighborhood Hits	296
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

ANR16_HUMAN
θ value	6.62687e-19 (rank : 33)	NC score	0.887157 (rank : 6)
Query Neighborhood Hits	453	Target Neighborhood Hits	286	Shared Neighborhood Hits	281
SwissProt Accessions	Q6P6B7, Q9NT01	Gene names	ANKRD16
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 16.

ASB10_MOUSE
θ value	6.62687e-19 (rank : 34)	NC score	0.866611 (rank : 26)
Query Neighborhood Hits	453	Target Neighborhood Hits	301	Shared Neighborhood Hits	284
SwissProt Accessions	Q91ZT7	Gene names	Asb10
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

TRPA1_MOUSE
θ value	4.29542e-18 (rank : 35)	NC score	0.850741 (rank : 40)
Query Neighborhood Hits	453	Target Neighborhood Hits	343	Shared Neighborhood Hits	292
SwissProt Accessions	Q8BLA8	Gene names	Trpa1, Anktm1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1).

ASB13_MOUSE
θ value	2.7842e-17 (rank : 36)	NC score	0.853798 (rank : 36)
Query Neighborhood Hits	453	Target Neighborhood Hits	293	Shared Neighborhood Hits	281
SwissProt Accessions	Q8VBX0	Gene names	Asb13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 13 (ASB-13).

ASB2_HUMAN
θ value	2.7842e-17 (rank : 37)	NC score	0.856190 (rank : 35)
Query Neighborhood Hits	453	Target Neighborhood Hits	309	Shared Neighborhood Hits	288
SwissProt Accessions	Q96Q27, Q9NSU5, Q9Y567	Gene names	ASB2
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 2 (ASB-2).

ASB13_HUMAN
θ value	4.74913e-17 (rank : 38)	NC score	0.853668 (rank : 37)
Query Neighborhood Hits	453	Target Neighborhood Hits	293	Shared Neighborhood Hits	283
SwissProt Accessions	Q8WXK3, Q96EP7, Q9H8Z1	Gene names	ASB13
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 13 (ASB-13).

TRPA1_HUMAN
θ value	6.20254e-17 (rank : 39)	NC score	0.850029 (rank : 42)
Query Neighborhood Hits	453	Target Neighborhood Hits	339	Shared Neighborhood Hits	292
SwissProt Accessions	O75762	Gene names	TRPA1, ANKTM1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation sensitive-protein p120).

ASB10_HUMAN
θ value	8.10077e-17 (rank : 40)	NC score	0.864357 (rank : 30)
Query Neighborhood Hits	453	Target Neighborhood Hits	291	Shared Neighborhood Hits	282
SwissProt Accessions	Q8WXI3	Gene names	ASB10
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

ASB7_MOUSE
θ value	1.38178e-16 (rank : 41)	NC score	0.870825 (rank : 19)
Query Neighborhood Hits	453	Target Neighborhood Hits	296	Shared Neighborhood Hits	283
SwissProt Accessions	Q91ZU0	Gene names	Asb7
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 7 (ASB-7).

ANR42_HUMAN
θ value	1.80466e-16 (rank : 42)	NC score	0.871890 (rank : 16)
Query Neighborhood Hits	453	Target Neighborhood Hits	284	Shared Neighborhood Hits	279
SwissProt Accessions	Q8N9B4, Q49A49	Gene names	ANKRD42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

ASB2_MOUSE
θ value	5.25075e-16 (rank : 43)	NC score	0.851176 (rank : 39)
Query Neighborhood Hits	453	Target Neighborhood Hits	321	Shared Neighborhood Hits	287
SwissProt Accessions	Q8K0L0, Q9CTH4, Q9WV73	Gene names	Asb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 2 (ASB-2).

ANR42_MOUSE
θ value	6.85773e-16 (rank : 44)	NC score	0.868642 (rank : 24)
Query Neighborhood Hits	453	Target Neighborhood Hits	334	Shared Neighborhood Hits	282
SwissProt Accessions	Q3V096, Q8BX55, Q8BZT3, Q8C0T6, Q8C0X5	Gene names	Ankrd42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

ASB7_HUMAN
θ value	6.85773e-16 (rank : 45)	NC score	0.870252 (rank : 22)
Query Neighborhood Hits	453	Target Neighborhood Hits	296	Shared Neighborhood Hits	283
SwissProt Accessions	Q9H672, Q7Z4S3	Gene names	ASB7
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 7 (ASB-7).

EHMT1_HUMAN
θ value	1.52774e-15 (rank : 46)	NC score	0.802968 (rank : 109)
Query Neighborhood Hits	453	Target Neighborhood Hits	417	Shared Neighborhood Hits	299
SwissProt Accessions	Q9H9B1, Q8TCN7, Q96F53, Q96JF1, Q96KH4	Gene names	EHMT1, EUHMTASE1, KIAA1876
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a- like protein 1) (GLP1).

ANR29_HUMAN
θ value	1.99529e-15 (rank : 47)	NC score	0.888170 (rank : 5)
Query Neighborhood Hits	453	Target Neighborhood Hits	294	Shared Neighborhood Hits	291
SwissProt Accessions	Q8N6D5, Q6ZWE8, Q96LU9	Gene names	ANKRD29
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 29.

RAI14_HUMAN
θ value	1.99529e-15 (rank : 48)	NC score	0.639030 (rank : 185)
Query Neighborhood Hits	453	Target Neighborhood Hits	1367	Shared Neighborhood Hits	320
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

ASB14_MOUSE
θ value	2.60593e-15 (rank : 49)	NC score	0.824393 (rank : 70)
Query Neighborhood Hits	453	Target Neighborhood Hits	293	Shared Neighborhood Hits	274
SwissProt Accessions	Q8VHS7	Gene names	Asb14
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 14 (ASB-14).

IKBA_HUMAN
θ value	3.40345e-15 (rank : 50)	NC score	0.821602 (rank : 71)
Query Neighborhood Hits	453	Target Neighborhood Hits	280	Shared Neighborhood Hits	270
SwissProt Accessions	P25963	Gene names	NFKBIA, IKBA, MAD3, NFKBI
Domain Architecture
Description	NF-kappa-B inhibitor alpha (Major histocompatibility complex enhancer- binding protein MAD3) (I-kappa-B-alpha) (IkappaBalpha) (IKB-alpha).

EHMT2_HUMAN
θ value	7.58209e-15 (rank : 51)	NC score	0.790585 (rank : 117)
Query Neighborhood Hits	453	Target Neighborhood Hits	498	Shared Neighborhood Hits	300
SwissProt Accessions	Q96KQ7, Q14349, Q6PK06, Q96MH5, Q96QD0, Q9UQL8, Q9Y331	Gene names	EHMT2, BAT8, G9A, NG36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

ANFY1_HUMAN
θ value	1.29331e-14 (rank : 52)	NC score	0.763471 (rank : 131)
Query Neighborhood Hits	453	Target Neighborhood Hits	480	Shared Neighborhood Hits	286
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

MYPT1_MOUSE
θ value	1.29331e-14 (rank : 53)	NC score	0.826551 (rank : 67)
Query Neighborhood Hits	453	Target Neighborhood Hits	539	Shared Neighborhood Hits	290
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

RAI14_MOUSE
θ value	1.68911e-14 (rank : 54)	NC score	0.601432 (rank : 195)
Query Neighborhood Hits	453	Target Neighborhood Hits	1505	Shared Neighborhood Hits	311
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

EHMT2_MOUSE
θ value	3.76295e-14 (rank : 55)	NC score	0.775859 (rank : 124)
Query Neighborhood Hits	453	Target Neighborhood Hits	750	Shared Neighborhood Hits	304
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

MIB2_HUMAN
θ value	3.76295e-14 (rank : 56)	NC score	0.818024 (rank : 79)
Query Neighborhood Hits	453	Target Neighborhood Hits	438	Shared Neighborhood Hits	287
SwissProt Accessions	Q96AX9, Q7Z437, Q8IY62, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1	Gene names	MIB2, SKD, ZZANK1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N).

PSD10_HUMAN
θ value	4.91457e-14 (rank : 57)	NC score	0.877324 (rank : 10)
Query Neighborhood Hits	453	Target Neighborhood Hits	301	Shared Neighborhood Hits	292
SwissProt Accessions	O75832	Gene names	PSMD10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

IKBA_MOUSE
θ value	8.38298e-14 (rank : 58)	NC score	0.809903 (rank : 92)
Query Neighborhood Hits	453	Target Neighborhood Hits	283	Shared Neighborhood Hits	270
SwissProt Accessions	Q9Z1E3, Q80ZX5	Gene names	Nfkbia, Ikba
Domain Architecture	No domain graphic available
Description	NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkappaBalpha) (IKB- alpha).

MIB2_MOUSE
θ value	8.38298e-14 (rank : 59)	NC score	0.818061 (rank : 78)
Query Neighborhood Hits	453	Target Neighborhood Hits	409	Shared Neighborhood Hits	278
SwissProt Accessions	Q8R516, Q52QU8, Q6PEF6, Q8C1N7, Q8VIB4	Gene names	Mib2, Skd
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) (Dystrophin-like protein) (Dyslike).

ANKR2_MOUSE
θ value	1.09485e-13 (rank : 60)	NC score	0.851422 (rank : 38)
Query Neighborhood Hits	453	Target Neighborhood Hits	312	Shared Neighborhood Hits	289
SwissProt Accessions	Q9WV06	Gene names	Ankrd2, Arpp
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (mArpp).

PSD10_MOUSE
θ value	1.09485e-13 (rank : 61)	NC score	0.875360 (rank : 12)
Query Neighborhood Hits	453	Target Neighborhood Hits	293	Shared Neighborhood Hits	289
SwissProt Accessions	Q9Z2X2, Q9D7N8	Gene names	Psmd10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

ANFY1_MOUSE
θ value	1.42992e-13 (rank : 62)	NC score	0.763608 (rank : 130)
Query Neighborhood Hits	453	Target Neighborhood Hits	480	Shared Neighborhood Hits	293
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANKS6_MOUSE
θ value	1.42992e-13 (rank : 63)	NC score	0.843609 (rank : 47)
Query Neighborhood Hits	453	Target Neighborhood Hits	435	Shared Neighborhood Hits	306
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

OSBL1_HUMAN
θ value	2.43908e-13 (rank : 64)	NC score	0.673248 (rank : 175)
Query Neighborhood Hits	453	Target Neighborhood Hits	368	Shared Neighborhood Hits	281
SwissProt Accessions	Q9BXW6, Q9BZF5, Q9NW87	Gene names	OSBPL1A, ORP1, OSBP8, OSBPL1
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

ANKS6_HUMAN
θ value	3.18553e-13 (rank : 65)	NC score	0.842326 (rank : 48)
Query Neighborhood Hits	453	Target Neighborhood Hits	411	Shared Neighborhood Hits	303
SwissProt Accessions	Q68DC2, Q5VSL0, Q5VSL2, Q5VSL3, Q5VSL4, Q68DB8, Q6P2R2, Q8N9L6, Q96D62	Gene names	ANKS6, ANKRD14, SAMD6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6) (Ankyrin repeat domain-containing protein 14).

FANK1_HUMAN
θ value	4.16044e-13 (rank : 66)	NC score	0.861918 (rank : 32)
Query Neighborhood Hits	453	Target Neighborhood Hits	326	Shared Neighborhood Hits	291
SwissProt Accessions	Q8TC84, Q6UXY9, Q6X7T6	Gene names	FANK1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains protein 1.

OSBL1_MOUSE
θ value	7.09661e-13 (rank : 67)	NC score	0.661871 (rank : 179)
Query Neighborhood Hits	453	Target Neighborhood Hits	336	Shared Neighborhood Hits	283
SwissProt Accessions	Q91XL9, O88318, Q3TH97, Q673L8, Q6DFU6	Gene names	Osbpl1a, Orp1, Orp1a
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

CTTB2_HUMAN
θ value	9.26847e-13 (rank : 68)	NC score	0.741551 (rank : 142)
Query Neighborhood Hits	453	Target Neighborhood Hits	1061	Shared Neighborhood Hits	312
SwissProt Accessions	Q8WZ74, O43389, Q7LG11, Q9C0A5	Gene names	CTTNBP2, C7orf8, CORTBP2, KIAA1758
Domain Architecture	No domain graphic available
Description	Cortactin-binding protein 2 (CortBP2).

NOTC1_HUMAN
θ value	2.69671e-12 (rank : 69)	NC score	0.410539 (rank : 258)
Query Neighborhood Hits	453	Target Neighborhood Hits	906	Shared Neighborhood Hits	290
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

ANKR1_HUMAN
θ value	3.52202e-12 (rank : 70)	NC score	0.842111 (rank : 49)
Query Neighborhood Hits	453	Target Neighborhood Hits	308	Shared Neighborhood Hits	281
SwissProt Accessions	Q15327, Q96LE7	Gene names	ANKRD1, C193, CARP, HA1A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) (Cytokine-inducible nuclear protein) (C-193).

ANR23_MOUSE
θ value	3.52202e-12 (rank : 71)	NC score	0.850298 (rank : 41)
Query Neighborhood Hits	453	Target Neighborhood Hits	296	Shared Neighborhood Hits	286
SwissProt Accessions	Q812A3	Gene names	Ankrd23, Darp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein).

ASB9_HUMAN
θ value	3.52202e-12 (rank : 72)	NC score	0.820872 (rank : 73)
Query Neighborhood Hits	453	Target Neighborhood Hits	267	Shared Neighborhood Hits	259
SwissProt Accessions	Q96DX5, Q9NWS5, Q9Y4T3	Gene names	ASB9
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 9 (ASB-9).

MYPT2_HUMAN
θ value	4.59992e-12 (rank : 73)	NC score	0.809911 (rank : 91)
Query Neighborhood Hits	453	Target Neighborhood Hits	707	Shared Neighborhood Hits	294
SwissProt Accessions	O60237, Q8N179, Q9HCB7, Q9HCB8	Gene names	PPP1R12B, MYPT2
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase- targeting subunit 2) (Myosin phosphatase target subunit 2).

MYPT1_HUMAN
θ value	6.00763e-12 (rank : 74)	NC score	0.805831 (rank : 101)
Query Neighborhood Hits	453	Target Neighborhood Hits	723	Shared Neighborhood Hits	292
SwissProt Accessions	O14974, Q86WU3, Q8NFR6, Q9BYH0	Gene names	PPP1R12A, MBS, MYPT1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit).

PP16A_MOUSE
θ value	6.00763e-12 (rank : 75)	NC score	0.825778 (rank : 68)
Query Neighborhood Hits	453	Target Neighborhood Hits	318	Shared Neighborhood Hits	283
SwissProt Accessions	Q923M0, Q4V9Z1	Gene names	Ppp1r16a, Mypt3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase targeting subunit 3).

FANK1_MOUSE
θ value	7.84624e-12 (rank : 76)	NC score	0.859665 (rank : 33)
Query Neighborhood Hits	453	Target Neighborhood Hits	325	Shared Neighborhood Hits	289
SwissProt Accessions	Q9DAM9, Q9CUA7	Gene names	Fank1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains 1 protein (Germ cell- specific gene 1 protein) (GSG1).

RN5A_MOUSE
θ value	7.84624e-12 (rank : 77)	NC score	0.758250 (rank : 133)
Query Neighborhood Hits	453	Target Neighborhood Hits	899	Shared Neighborhood Hits	317
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

ANR35_HUMAN
θ value	1.02475e-11 (rank : 78)	NC score	0.778272 (rank : 123)
Query Neighborhood Hits	453	Target Neighborhood Hits	784	Shared Neighborhood Hits	294
SwissProt Accessions	Q8N283, Q3MJ10, Q96LS3	Gene names	ANKRD35
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 35.

PP16A_HUMAN
θ value	1.02475e-11 (rank : 79)	NC score	0.820309 (rank : 74)
Query Neighborhood Hits	453	Target Neighborhood Hits	340	Shared Neighborhood Hits	278
SwissProt Accessions	Q96I34	Gene names	PPP1R16A, MYPT3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase- targeting subunit 3).

ASB15_HUMAN
θ value	1.33837e-11 (rank : 80)	NC score	0.828427 (rank : 62)
Query Neighborhood Hits	453	Target Neighborhood Hits	305	Shared Neighborhood Hits	280
SwissProt Accessions	Q8WXK1	Gene names	ASB15
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 15 (ASB-15).

ANKR2_HUMAN
θ value	2.28291e-11 (rank : 81)	NC score	0.846700 (rank : 45)
Query Neighborhood Hits	453	Target Neighborhood Hits	321	Shared Neighborhood Hits	288
SwissProt Accessions	Q9GZV1, Q5T456, Q8WUD7	Gene names	ANKRD2, ARPP
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp).

ANKS3_MOUSE
θ value	2.28291e-11 (rank : 82)	NC score	0.827774 (rank : 65)
Query Neighborhood Hits	453	Target Neighborhood Hits	355	Shared Neighborhood Hits	283
SwissProt Accessions	Q9CZK6, Q6ZPF6, Q80X46	Gene names	Anks3, Kiaa1977
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 3.

ANR23_HUMAN
θ value	2.28291e-11 (rank : 83)	NC score	0.844377 (rank : 46)
Query Neighborhood Hits	453	Target Neighborhood Hits	291	Shared Neighborhood Hits	283
SwissProt Accessions	Q86SG2, Q711K7, Q8NAJ7	Gene names	ANKRD23, DARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein) (Muscle ankyrin repeat protein 3).

ANR39_HUMAN
θ value	5.08577e-11 (rank : 84)	NC score	0.849011 (rank : 43)
Query Neighborhood Hits	453	Target Neighborhood Hits	285	Shared Neighborhood Hits	280
SwissProt Accessions	Q53RE8, Q59FU2, Q8N5X5, Q9P0S5	Gene names	ANKRD39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ANR39_MOUSE
θ value	5.08577e-11 (rank : 85)	NC score	0.847753 (rank : 44)
Query Neighborhood Hits	453	Target Neighborhood Hits	284	Shared Neighborhood Hits	279
SwissProt Accessions	Q9D2X0	Gene names	Ankrd39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

POTE8_HUMAN
θ value	6.64225e-11 (rank : 86)	NC score	0.760808 (rank : 132)
Query Neighborhood Hits	453	Target Neighborhood Hits	337	Shared Neighborhood Hits	285
SwissProt Accessions	Q6S8J7, Q6S8J6	Gene names	POTE8
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 8.

ASB11_HUMAN
θ value	1.133e-10 (rank : 87)	NC score	0.813773 (rank : 83)
Query Neighborhood Hits	453	Target Neighborhood Hits	271	Shared Neighborhood Hits	261
SwissProt Accessions	Q8WXH4, Q3SYC4	Gene names	ASB11
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 11 (ASB-11).

ZDH13_MOUSE
θ value	1.133e-10 (rank : 88)	NC score	0.735449 (rank : 146)
Query Neighborhood Hits	453	Target Neighborhood Hits	329	Shared Neighborhood Hits	278
SwissProt Accessions	Q9CWU2, Q3UK32, Q3UKV1	Gene names	Zdhhc13, Hip14l
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC13 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein).

RN5A_HUMAN
θ value	1.47974e-10 (rank : 89)	NC score	0.804916 (rank : 104)
Query Neighborhood Hits	453	Target Neighborhood Hits	608	Shared Neighborhood Hits	299
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

ASB16_MOUSE
θ value	1.9326e-10 (rank : 90)	NC score	0.827847 (rank : 64)
Query Neighborhood Hits	453	Target Neighborhood Hits	306	Shared Neighborhood Hits	279
SwissProt Accessions	Q8VHS5, Q8BYT0	Gene names	Asb16
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 16 (ASB-16).

NFKB1_HUMAN
θ value	2.52405e-10 (rank : 91)	NC score	0.716006 (rank : 155)
Query Neighborhood Hits	453	Target Neighborhood Hits	306	Shared Neighborhood Hits	274
SwissProt Accessions	P19838, Q68D84, Q86V43, Q8N4X7, Q9NZC0	Gene names	NFKB1
Domain Architecture
Description	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) [Contains: Nuclear factor NF-kappa-B p50 subunit].

NOTC1_MOUSE
θ value	2.52405e-10 (rank : 92)	NC score	0.350371 (rank : 267)
Query Neighborhood Hits	453	Target Neighborhood Hits	916	Shared Neighborhood Hits	266
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

NOTC3_HUMAN
θ value	2.52405e-10 (rank : 93)	NC score	0.411433 (rank : 257)
Query Neighborhood Hits	453	Target Neighborhood Hits	1062	Shared Neighborhood Hits	304
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

RFXK_HUMAN
θ value	2.52405e-10 (rank : 94)	NC score	0.808524 (rank : 95)
Query Neighborhood Hits	453	Target Neighborhood Hits	282	Shared Neighborhood Hits	266
SwissProt Accessions	O14593, O95839	Gene names	RFXANK, ANKRA1, RFXB
Domain Architecture
Description	DNA-binding protein RFXANK (Regulatory factor X subunit B) (RFX-B) (Ankyrin repeat family A protein 1).

ANKR1_MOUSE
θ value	3.29651e-10 (rank : 95)	NC score	0.839715 (rank : 50)
Query Neighborhood Hits	453	Target Neighborhood Hits	316	Shared Neighborhood Hits	289
SwissProt Accessions	Q9CR42, O55014, Q3UIF7, Q3UJ39, Q792Q9	Gene names	Ankrd1, Carp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein).

ASB11_MOUSE
θ value	3.29651e-10 (rank : 96)	NC score	0.812296 (rank : 86)
Query Neighborhood Hits	453	Target Neighborhood Hits	271	Shared Neighborhood Hits	257
SwissProt Accessions	Q9CQ31, Q3UJ13, Q9D0V1	Gene names	Asb11
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 11 (ASB-11).

GABP2_MOUSE
θ value	3.29651e-10 (rank : 97)	NC score	0.837815 (rank : 51)
Query Neighborhood Hits	453	Target Neighborhood Hits	429	Shared Neighborhood Hits	292
SwissProt Accessions	Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2	Gene names	Gabpb2, Gabpb, Gabpb1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1).

ZDH13_HUMAN
θ value	3.29651e-10 (rank : 98)	NC score	0.735630 (rank : 145)
Query Neighborhood Hits	453	Target Neighborhood Hits	322	Shared Neighborhood Hits	275
SwissProt Accessions	Q8IUH4, Q7Z2D3, Q86VK2, Q9NV30, Q9NV99	Gene names	ZDHHC13, HIP14L, HIP3RP
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC13 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein) (Huntingtin- interacting protein HIP3RP) (Putative NF-kappa-B-activating protein 209) (Putative MAPK-activating protein PM03).

ASB12_MOUSE
θ value	4.30538e-10 (rank : 99)	NC score	0.806434 (rank : 98)
Query Neighborhood Hits	453	Target Neighborhood Hits	261	Shared Neighborhood Hits	258
SwissProt Accessions	Q9D738	Gene names	Asb12
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 12 (ASB-12).

ASB15_MOUSE
θ value	4.30538e-10 (rank : 100)	NC score	0.818933 (rank : 75)
Query Neighborhood Hits	453	Target Neighborhood Hits	292	Shared Neighborhood Hits	272
SwissProt Accessions	Q8VHS6	Gene names	Asb15
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 15 (ASB-15).

BCL3_HUMAN
θ value	4.30538e-10 (rank : 101)	NC score	0.833085 (rank : 58)
Query Neighborhood Hits	453	Target Neighborhood Hits	324	Shared Neighborhood Hits	283
SwissProt Accessions	P20749	Gene names	BCL3
Domain Architecture
Description	B-cell lymphoma 3-encoded protein (Protein Bcl-3).

BCL3_MOUSE
θ value	4.30538e-10 (rank : 102)	NC score	0.829628 (rank : 61)
Query Neighborhood Hits	453	Target Neighborhood Hits	388	Shared Neighborhood Hits	287
SwissProt Accessions	Q9Z2F6	Gene names	Bcl3
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 3-encoded protein homolog (Protein Bcl-3).

NOTC3_MOUSE
θ value	4.30538e-10 (rank : 103)	NC score	0.413184 (rank : 255)
Query Neighborhood Hits	453	Target Neighborhood Hits	975	Shared Neighborhood Hits	304
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

ANR15_HUMAN
θ value	5.62301e-10 (rank : 104)	NC score	0.734356 (rank : 148)
Query Neighborhood Hits	453	Target Neighborhood Hits	478	Shared Neighborhood Hits	275
SwissProt Accessions	Q14678, Q5W0W0, Q8IY65, Q8WX74	Gene names	ANKRD15, KANK, KIAA0172
Domain Architecture
Description	Ankyrin repeat domain-containing protein 15 (Kidney ankyrin repeat- containing protein).

ASB12_HUMAN
θ value	5.62301e-10 (rank : 105)	NC score	0.804936 (rank : 103)
Query Neighborhood Hits	453	Target Neighborhood Hits	263	Shared Neighborhood Hits	263
SwissProt Accessions	Q8WXK4, Q52LK4, Q6ISF9	Gene names	ASB12
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 12 (ASB-12).

BARD1_HUMAN
θ value	5.62301e-10 (rank : 106)	NC score	0.787985 (rank : 118)
Query Neighborhood Hits	453	Target Neighborhood Hits	427	Shared Neighborhood Hits	289
SwissProt Accessions	Q99728, O43574	Gene names	BARD1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

POT15_HUMAN
θ value	5.62301e-10 (rank : 107)	NC score	0.712421 (rank : 157)
Query Neighborhood Hits	453	Target Neighborhood Hits	893	Shared Neighborhood Hits	295
SwissProt Accessions	Q6S5H4, Q6NXN7, Q6S5H7	Gene names	POTE15
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 15.

NOTC4_MOUSE
θ value	9.59137e-10 (rank : 108)	NC score	0.455833 (rank : 245)
Query Neighborhood Hits	453	Target Neighborhood Hits	872	Shared Neighborhood Hits	298
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

ZDH17_HUMAN
θ value	9.59137e-10 (rank : 109)	NC score	0.745417 (rank : 141)
Query Neighborhood Hits	453	Target Neighborhood Hits	334	Shared Neighborhood Hits	283
SwissProt Accessions	Q8IUH5, O75407, Q7Z2I0, Q86W89, Q86YK0, Q9P088, Q9UPZ8	Gene names	ZDHHC17, HIP14, HIP3, KIAA0946
Domain Architecture
Description	Palmitoyltransferase ZDHHC17 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 17) (DHHC-17) (Huntingtin-interacting protein 14) (Huntingtin-interacting protein 3) (Huntingtin-interacting protein HYPH) (Putative NF-kappa-B-activating protein 205) (Putative MAPK- activating protein PM11).

ANR11_HUMAN
θ value	1.25267e-09 (rank : 110)	NC score	0.735055 (rank : 147)
Query Neighborhood Hits	453	Target Neighborhood Hits	1289	Shared Neighborhood Hits	317
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

ANR21_HUMAN
θ value	1.25267e-09 (rank : 111)	NC score	0.711908 (rank : 158)
Query Neighborhood Hits	453	Target Neighborhood Hits	864	Shared Neighborhood Hits	295
SwissProt Accessions	Q86YR6	Gene names	ANKRD21, POTE
Domain Architecture
Description	Ankyrin repeat domain-containing protein 21 (Protein POTE) (Prostate, ovary, testis-expressed protein).

NOTC4_HUMAN
θ value	1.25267e-09 (rank : 112)	NC score	0.450029 (rank : 247)
Query Neighborhood Hits	453	Target Neighborhood Hits	905	Shared Neighborhood Hits	298
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

ASB8_MOUSE
θ value	2.13673e-09 (rank : 113)	NC score	0.834993 (rank : 52)
Query Neighborhood Hits	453	Target Neighborhood Hits	293	Shared Neighborhood Hits	280
SwissProt Accessions	Q91ZT9, Q8R178	Gene names	Asb8
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 8 (ASB-8).

GABP2_HUMAN
θ value	2.13673e-09 (rank : 114)	NC score	0.834225 (rank : 54)
Query Neighborhood Hits	453	Target Neighborhood Hits	454	Shared Neighborhood Hits	292
SwissProt Accessions	Q06547, Q06545, Q12940, Q12941, Q12942, Q8IYD0	Gene names	GABPB2, E4TF1B, GABPB, GABPB1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1) (Transcription factor E4TF1-53) (Transcription factor E4TF1-47) (Nuclear respiratory factor 2).

ZDH17_MOUSE
θ value	2.13673e-09 (rank : 115)	NC score	0.740783 (rank : 143)
Query Neighborhood Hits	453	Target Neighborhood Hits	328	Shared Neighborhood Hits	279
SwissProt Accessions	Q80TN5, Q8BJ08, Q8BYQ2, Q8BYQ6	Gene names	Zdhhc17, Hip14, Kiaa0946
Domain Architecture
Description	Palmitoyltransferase ZDHHC17 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 17) (DHHC-17) (Huntingtin-interacting protein 14).

ANKS3_HUMAN
θ value	2.79066e-09 (rank : 116)	NC score	0.821251 (rank : 72)
Query Neighborhood Hits	453	Target Neighborhood Hits	355	Shared Neighborhood Hits	282
SwissProt Accessions	Q6ZW76, Q8TF25	Gene names	ANKS3, KIAA1977
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 3.

ASB8_HUMAN
θ value	2.79066e-09 (rank : 117)	NC score	0.833851 (rank : 55)
Query Neighborhood Hits	453	Target Neighborhood Hits	294	Shared Neighborhood Hits	281
SwissProt Accessions	Q9H765, Q547Q2	Gene names	ASB8
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 8 (ASB-8).

CDN2C_MOUSE
θ value	2.79066e-09 (rank : 118)	NC score	0.833552 (rank : 56)
Query Neighborhood Hits	453	Target Neighborhood Hits	270	Shared Neighborhood Hits	268
SwissProt Accessions	Q60772	Gene names	Cdkn2c
Domain Architecture
Description	Cyclin-dependent kinase 6 inhibitor (p18-INK6) (Cyclin-dependent kinase 4 inhibitor C) (p18-INK4c).

ANRA2_HUMAN
θ value	6.21693e-09 (rank : 119)	NC score	0.814350 (rank : 82)
Query Neighborhood Hits	453	Target Neighborhood Hits	288	Shared Neighborhood Hits	281
SwissProt Accessions	Q9H9E1	Gene names	ANKRA2, ANKRA
Domain Architecture
Description	Ankyrin repeat family A protein 2 (RFXANK-like 2).

ASB4_HUMAN
θ value	6.21693e-09 (rank : 120)	NC score	0.803982 (rank : 108)
Query Neighborhood Hits	453	Target Neighborhood Hits	264	Shared Neighborhood Hits	256
SwissProt Accessions	Q9Y574, O14586	Gene names	ASB4
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 4 (ASB-4).

BARD1_MOUSE
θ value	6.21693e-09 (rank : 121)	NC score	0.785566 (rank : 121)
Query Neighborhood Hits	453	Target Neighborhood Hits	411	Shared Neighborhood Hits	282
SwissProt Accessions	O70445	Gene names	Bard1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

NFKB1_MOUSE
θ value	6.21693e-09 (rank : 122)	NC score	0.715067 (rank : 156)
Query Neighborhood Hits	453	Target Neighborhood Hits	300	Shared Neighborhood Hits	267
SwissProt Accessions	P25799, Q3TZE8, Q3V2V6, Q6TDG8, Q75ZL1, Q80Y21, Q8C712	Gene names	Nfkb1
Domain Architecture
Description	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) (NF-kappa-B1 p84/NF-kappa-B1 p98) [Contains: Nuclear factor NF- kappa-B p50 subunit].

SHAN1_HUMAN
θ value	6.21693e-09 (rank : 123)	NC score	0.710879 (rank : 159)
Query Neighborhood Hits	453	Target Neighborhood Hits	1041	Shared Neighborhood Hits	319
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

CDN2C_HUMAN
θ value	8.11959e-09 (rank : 124)	NC score	0.834336 (rank : 53)
Query Neighborhood Hits	453	Target Neighborhood Hits	262	Shared Neighborhood Hits	262
SwissProt Accessions	P42773, Q8TB83	Gene names	CDKN2C, CDKN6
Domain Architecture
Description	Cyclin-dependent kinase 6 inhibitor (p18-INK6) (Cyclin-dependent kinase 4 inhibitor C) (p18-INK4c).

PP16B_HUMAN
θ value	8.11959e-09 (rank : 125)	NC score	0.813474 (rank : 84)
Query Neighborhood Hits	453	Target Neighborhood Hits	307	Shared Neighborhood Hits	283
SwissProt Accessions	Q96T49, O94912, Q9NQG4	Gene names	PPP1R16B, ANKRD4, KIAA0823
Domain Architecture
Description	Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein) (hTIMAP) (CAAX box protein TIMAP) (Ankyrin repeat domain protein 4).

ANR10_MOUSE
θ value	1.06045e-08 (rank : 126)	NC score	0.805676 (rank : 102)
Query Neighborhood Hits	453	Target Neighborhood Hits	273	Shared Neighborhood Hits	264
SwissProt Accessions	Q99LW0	Gene names	Ankrd10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

ASB4_MOUSE
θ value	1.06045e-08 (rank : 127)	NC score	0.802316 (rank : 110)
Query Neighborhood Hits	453	Target Neighborhood Hits	265	Shared Neighborhood Hits	256
SwissProt Accessions	Q9WV71	Gene names	Asb4
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 4 (ASB-4).

ASB16_HUMAN
θ value	1.38499e-08 (rank : 128)	NC score	0.818306 (rank : 76)
Query Neighborhood Hits	453	Target Neighborhood Hits	286	Shared Neighborhood Hits	268
SwissProt Accessions	Q96NS5, Q8WXK0	Gene names	ASB16
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 16 (ASB-16).

ASB9_MOUSE
θ value	1.38499e-08 (rank : 129)	NC score	0.806037 (rank : 99)
Query Neighborhood Hits	453	Target Neighborhood Hits	257	Shared Neighborhood Hits	252
SwissProt Accessions	Q91ZT8, Q9DAF7	Gene names	Asb9
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 9 (ASB-9).

PA2G6_MOUSE
θ value	1.38499e-08 (rank : 130)	NC score	0.827095 (rank : 66)
Query Neighborhood Hits	453	Target Neighborhood Hits	293	Shared Neighborhood Hits	282
SwissProt Accessions	P97819, Q99LA9, Q9JK61	Gene names	Pla2g6
Domain Architecture
Description	85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4) (iPLA2) (CaI- PLA2) (Group VI phospholipase A2) (GVI PLA2).

AN36B_HUMAN
θ value	1.80886e-08 (rank : 131)	NC score	0.782785 (rank : 122)
Query Neighborhood Hits	453	Target Neighborhood Hits	294	Shared Neighborhood Hits	283
SwissProt Accessions	Q8N2N9, Q6IPR0	Gene names	ANKRD36B
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 36B.

ASZ1_HUMAN
θ value	1.80886e-08 (rank : 132)	NC score	0.815815 (rank : 80)
Query Neighborhood Hits	453	Target Neighborhood Hits	341	Shared Neighborhood Hits	279
SwissProt Accessions	Q8WWH4	Gene names	ASZ1, GASZ
Domain Architecture
Description	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).

ANR12_HUMAN
θ value	2.36244e-08 (rank : 133)	NC score	0.707451 (rank : 161)
Query Neighborhood Hits	453	Target Neighborhood Hits	1081	Shared Neighborhood Hits	302
SwissProt Accessions	Q6UB98, O94951, Q658K1, Q6QMF7, Q9H231, Q9H784	Gene names	ANKRD12, ANCO2, KIAA0874
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein).

ASB1_HUMAN
θ value	2.36244e-08 (rank : 134)	NC score	0.797326 (rank : 112)
Query Neighborhood Hits	453	Target Neighborhood Hits	291	Shared Neighborhood Hits	279
SwissProt Accessions	Q9Y576, Q9ULS4	Gene names	ASB1, KIAA1146
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 1 (ASB-1).

RFXK_MOUSE
θ value	3.08544e-08 (rank : 135)	NC score	0.796298 (rank : 113)
Query Neighborhood Hits	453	Target Neighborhood Hits	273	Shared Neighborhood Hits	267
SwissProt Accessions	Q9Z205	Gene names	Rfxank, Rfxb, Tvl1
Domain Architecture
Description	DNA-binding protein RFXANK (Regulatory factor X subunit B) (RFX-B) (Regulatory factor X-associated ankyrin-containing protein) (Ankyrin repeat-containing adapter protein Tvl-1).

ANR10_HUMAN
θ value	4.0297e-08 (rank : 136)	NC score	0.804437 (rank : 105)
Query Neighborhood Hits	453	Target Neighborhood Hits	289	Shared Neighborhood Hits	264
SwissProt Accessions	Q9NXR5	Gene names	ANKRD10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

PP16B_MOUSE
θ value	4.0297e-08 (rank : 137)	NC score	0.810939 (rank : 89)
Query Neighborhood Hits	453	Target Neighborhood Hits	302	Shared Neighborhood Hits	281
SwissProt Accessions	Q8VHQ3	Gene names	Ppp1r16b
Domain Architecture
Description	Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein) (CAAX box protein TIMAP).

UACA_HUMAN
θ value	4.0297e-08 (rank : 138)	NC score	0.492533 (rank : 232)
Query Neighborhood Hits	453	Target Neighborhood Hits	1622	Shared Neighborhood Hits	312
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

ANKR5_MOUSE
θ value	5.26297e-08 (rank : 139)	NC score	0.812823 (rank : 85)
Query Neighborhood Hits	453	Target Neighborhood Hits	298	Shared Neighborhood Hits	283
SwissProt Accessions	Q9D2J7	Gene names	Ankrd5
Domain Architecture
Description	Ankyrin repeat domain-containing protein 5.

GABP3_MOUSE
θ value	5.26297e-08 (rank : 140)	NC score	0.833265 (rank : 57)
Query Neighborhood Hits	453	Target Neighborhood Hits	330	Shared Neighborhood Hits	279
SwissProt Accessions	P81069	Gene names	Gabpb2
Domain Architecture	No domain graphic available
Description	GA-binding protein beta-2-1 chain (GABP subunit beta-2-1) (GABPB2-1).

ILK_MOUSE
θ value	5.26297e-08 (rank : 141)	NC score	0.525590 (rank : 223)
Query Neighborhood Hits	453	Target Neighborhood Hits	858	Shared Neighborhood Hits	311
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

PA2G6_HUMAN
θ value	5.26297e-08 (rank : 142)	NC score	0.814651 (rank : 81)
Query Neighborhood Hits	453	Target Neighborhood Hits	284	Shared Neighborhood Hits	275
SwissProt Accessions	O60733, O75645, Q8N452, Q9UG29, Q9UIT0, Q9Y671	Gene names	PLA2G6, IPLA2
Domain Architecture
Description	85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4) (iPLA2) (CaI- PLA2) (Group VI phospholipase A2) (GVI PLA2).

NOTC2_HUMAN
θ value	6.87365e-08 (rank : 143)	NC score	0.405870 (rank : 259)
Query Neighborhood Hits	453	Target Neighborhood Hits	1113	Shared Neighborhood Hits	297
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

NOTC2_MOUSE
θ value	6.87365e-08 (rank : 144)	NC score	0.404231 (rank : 260)
Query Neighborhood Hits	453	Target Neighborhood Hits	1069	Shared Neighborhood Hits	298
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

NUMBL_MOUSE
θ value	6.87365e-08 (rank : 145)	NC score	0.165805 (rank : 300)
Query Neighborhood Hits	453	Target Neighborhood Hits	147	Shared Neighborhood Hits	24
SwissProt Accessions	O08919, Q6NVG8	Gene names	Numbl, Nbl
Domain Architecture
Description	Numb-like protein.

ASB5_MOUSE
θ value	8.97725e-08 (rank : 146)	NC score	0.806464 (rank : 97)
Query Neighborhood Hits	453	Target Neighborhood Hits	266	Shared Neighborhood Hits	260
SwissProt Accessions	Q9D1A4	Gene names	Asb5
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 5 (ASB-5).

ANKR5_HUMAN
θ value	1.17247e-07 (rank : 147)	NC score	0.810961 (rank : 88)
Query Neighborhood Hits	453	Target Neighborhood Hits	297	Shared Neighborhood Hits	283
SwissProt Accessions	Q9NU02, Q9H6Y9	Gene names	ANKRD5
Domain Architecture
Description	Ankyrin repeat domain-containing protein 5.

ANKR7_HUMAN
θ value	1.17247e-07 (rank : 148)	NC score	0.805969 (rank : 100)
Query Neighborhood Hits	453	Target Neighborhood Hits	286	Shared Neighborhood Hits	280
SwissProt Accessions	Q92527, Q96QN1, Q9UDM3	Gene names	ANKRD7
Domain Architecture
Description	Ankyrin repeat domain-containing protein 7 (Testis-specific protein TSA806).

ANR47_MOUSE
θ value	1.17247e-07 (rank : 149)	NC score	0.731680 (rank : 151)
Query Neighborhood Hits	453	Target Neighborhood Hits	350	Shared Neighborhood Hits	265
SwissProt Accessions	Q9Z1P7	Gene names	Ankrd47, D17Ertd288e, Ng28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

ARH_MOUSE
θ value	1.17247e-07 (rank : 150)	NC score	0.186026 (rank : 295)
Query Neighborhood Hits	453	Target Neighborhood Hits	32	Shared Neighborhood Hits	20
SwissProt Accessions	Q8C142, Q6NWV6, Q8VDQ0	Gene names	Ldlrap1, Arh
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein homolog).

ILK1_HUMAN
θ value	1.17247e-07 (rank : 151)	NC score	0.526766 (rank : 221)
Query Neighborhood Hits	453	Target Neighborhood Hits	857	Shared Neighborhood Hits	311
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	1.17247e-07 (rank : 152)	NC score	0.543695 (rank : 216)
Query Neighborhood Hits	453	Target Neighborhood Hits	848	Shared Neighborhood Hits	311
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ASB5_HUMAN
θ value	1.53129e-07 (rank : 153)	NC score	0.809624 (rank : 93)
Query Neighborhood Hits	453	Target Neighborhood Hits	283	Shared Neighborhood Hits	272
SwissProt Accessions	Q8WWX0	Gene names	ASB5
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 5 (ASB-5).

ASB1_MOUSE
θ value	1.99992e-07 (rank : 154)	NC score	0.795838 (rank : 114)
Query Neighborhood Hits	453	Target Neighborhood Hits	292	Shared Neighborhood Hits	279
SwissProt Accessions	Q9WV74	Gene names	Asb1
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 1 (ASB-1).

GLSL_MOUSE
θ value	1.99992e-07 (rank : 155)	NC score	0.541289 (rank : 217)
Query Neighborhood Hits	453	Target Neighborhood Hits	212	Shared Neighborhood Hits	204
SwissProt Accessions	Q571F8	Gene names	Gls2, Kiaa4146
Domain Architecture	No domain graphic available
Description	Glutaminase liver isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (L-glutaminase).

ANR18_HUMAN
θ value	2.61198e-07 (rank : 156)	NC score	0.597757 (rank : 198)
Query Neighborhood Hits	453	Target Neighborhood Hits	1106	Shared Neighborhood Hits	288
SwissProt Accessions	Q8IVF6, Q7Z468	Gene names	ANKRD18A, KIAA2015
Domain Architecture
Description	Ankyrin repeat domain-containing protein 18A.

CAPON_MOUSE
θ value	2.61198e-07 (rank : 157)	NC score	0.166492 (rank : 298)
Query Neighborhood Hits	453	Target Neighborhood Hits	34	Shared Neighborhood Hits	16
SwissProt Accessions	Q9D3A8, Q80TZ6	Gene names	Nos1ap, Capon, Kiaa0464
Domain Architecture	No domain graphic available
Description	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein).

CDN2D_HUMAN
θ value	3.41135e-07 (rank : 158)	NC score	0.818268 (rank : 77)
Query Neighborhood Hits	453	Target Neighborhood Hits	268	Shared Neighborhood Hits	267
SwissProt Accessions	P55273, Q13102, Q6FGE9	Gene names	CDKN2D
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

CDN2D_MOUSE
θ value	3.41135e-07 (rank : 159)	NC score	0.809556 (rank : 94)
Query Neighborhood Hits	453	Target Neighborhood Hits	267	Shared Neighborhood Hits	266
SwissProt Accessions	Q60773, Q60794	Gene names	Cdkn2d
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

NUMB_HUMAN
θ value	3.41135e-07 (rank : 160)	NC score	0.165522 (rank : 301)
Query Neighborhood Hits	453	Target Neighborhood Hits	112	Shared Neighborhood Hits	27
SwissProt Accessions	P49757, Q6NUQ7, Q86SY1, Q8WW73, Q9UBG1, Q9UEQ4, Q9UKE8, Q9UKE9, Q9UKF0, Q9UQJ4	Gene names	NUMB
Domain Architecture
Description	Protein numb homolog (h-Numb) (Protein S171).

NUMB_MOUSE
θ value	3.41135e-07 (rank : 161)	NC score	0.167787 (rank : 297)
Query Neighborhood Hits	453	Target Neighborhood Hits	91	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QZS3, P70422, Q8CIB1, Q9DC57, Q9QZR1, Q9QZS4	Gene names	Numb
Domain Architecture
Description	Protein numb homolog (m-Numb) (m-Nb).

OSTF1_MOUSE
θ value	3.41135e-07 (rank : 162)	NC score	0.650211 (rank : 184)
Query Neighborhood Hits	453	Target Neighborhood Hits	467	Shared Neighborhood Hits	265
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

ANRA2_MOUSE
θ value	4.45536e-07 (rank : 163)	NC score	0.809984 (rank : 90)
Query Neighborhood Hits	453	Target Neighborhood Hits	287	Shared Neighborhood Hits	281
SwissProt Accessions	Q99PE2	Gene names	Ankra2, Ankra
Domain Architecture
Description	Ankyrin repeat family A protein 2 (RFXANK-like 2).

NUMBL_HUMAN
θ value	4.45536e-07 (rank : 164)	NC score	0.147647 (rank : 310)
Query Neighborhood Hits	453	Target Neighborhood Hits	394	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y6R0, Q7Z4J9	Gene names	NUMBL
Domain Architecture
Description	Numb-like protein (Numb-R).

UACA_MOUSE
θ value	4.45536e-07 (rank : 165)	NC score	0.466665 (rank : 238)
Query Neighborhood Hits	453	Target Neighborhood Hits	1620	Shared Neighborhood Hits	307
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

ASZ1_MOUSE
θ value	5.81887e-07 (rank : 166)	NC score	0.811842 (rank : 87)
Query Neighborhood Hits	453	Target Neighborhood Hits	319	Shared Neighborhood Hits	280
SwissProt Accessions	Q8VD46, Q9JKQ7	Gene names	Asz1, Gasz
Domain Architecture
Description	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).

ARH_HUMAN
θ value	7.59969e-07 (rank : 167)	NC score	0.187416 (rank : 294)
Query Neighborhood Hits	453	Target Neighborhood Hits	38	Shared Neighborhood Hits	24
SwissProt Accessions	Q5SW96, Q6TQS9, Q8N2Y0, Q9UFI9	Gene names	LDLRAP1, ARH
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein).

ANR49_HUMAN
θ value	9.92553e-07 (rank : 168)	NC score	0.825740 (rank : 69)
Query Neighborhood Hits	453	Target Neighborhood Hits	282	Shared Neighborhood Hits	276
SwissProt Accessions	Q8WVL7, Q8NDF2, Q96JE5, Q9NXK7	Gene names	ANKRD49, FGIF
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor).

CAPON_HUMAN
θ value	9.92553e-07 (rank : 169)	NC score	0.166153 (rank : 299)
Query Neighborhood Hits	453	Target Neighborhood Hits	35	Shared Neighborhood Hits	15
SwissProt Accessions	O75052, O43564	Gene names	NOS1AP, CAPON, KIAA0464
Domain Architecture	No domain graphic available
Description	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein).

NFKB2_MOUSE
θ value	1.29631e-06 (rank : 170)	NC score	0.689345 (rank : 171)
Query Neighborhood Hits	453	Target Neighborhood Hits	326	Shared Neighborhood Hits	274
SwissProt Accessions	Q9WTK5	Gene names	Nfkb2
Domain Architecture
Description	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) [Contains: Nuclear factor NF-kappa-B p52 subunit].

OSTF1_HUMAN
θ value	1.29631e-06 (rank : 171)	NC score	0.631640 (rank : 192)
Query Neighborhood Hits	453	Target Neighborhood Hits	466	Shared Neighborhood Hits	263
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

ANR22_HUMAN
θ value	1.69304e-06 (rank : 172)	NC score	0.800091 (rank : 111)
Query Neighborhood Hits	453	Target Neighborhood Hits	243	Shared Neighborhood Hits	241
SwissProt Accessions	Q5VYY1, Q8WU06	Gene names	ANKRD22
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 22.

ANR47_HUMAN
θ value	1.69304e-06 (rank : 173)	NC score	0.704499 (rank : 163)
Query Neighborhood Hits	453	Target Neighborhood Hits	369	Shared Neighborhood Hits	259
SwissProt Accessions	Q6NY19, Q6NZI1, Q6ZQR3, Q8IUV2	Gene names	ANKRD47
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

SLY_HUMAN
θ value	1.69304e-06 (rank : 174)	NC score	0.148653 (rank : 309)
Query Neighborhood Hits	453	Target Neighborhood Hits	81	Shared Neighborhood Hits	17
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SLY_MOUSE
θ value	1.69304e-06 (rank : 175)	NC score	0.149412 (rank : 308)
Query Neighborhood Hits	453	Target Neighborhood Hits	108	Shared Neighborhood Hits	21
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

ANR49_MOUSE
θ value	2.21117e-06 (rank : 176)	NC score	0.828125 (rank : 63)
Query Neighborhood Hits	453	Target Neighborhood Hits	285	Shared Neighborhood Hits	279
SwissProt Accessions	Q8VE42, Q9Z2S1	Gene names	Ankrd49, Fgif, Gbif
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor) (Fetal globin-increasing factor).

IKBB_MOUSE
θ value	2.21117e-06 (rank : 177)	NC score	0.768169 (rank : 126)
Query Neighborhood Hits	453	Target Neighborhood Hits	284	Shared Neighborhood Hits	273
SwissProt Accessions	Q60778, Q9D6L5	Gene names	Nfkbib, Ikbb
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B).

SAMN1_MOUSE
θ value	2.21117e-06 (rank : 178)	NC score	0.152816 (rank : 302)
Query Neighborhood Hits	453	Target Neighborhood Hits	69	Shared Neighborhood Hits	17
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

AN30A_HUMAN
θ value	2.88788e-06 (rank : 179)	NC score	0.565994 (rank : 210)
Query Neighborhood Hits	453	Target Neighborhood Hits	1119	Shared Neighborhood Hits	287
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

ANS4B_HUMAN
θ value	3.77169e-06 (rank : 180)	NC score	0.748646 (rank : 138)
Query Neighborhood Hits	453	Target Neighborhood Hits	289	Shared Neighborhood Hits	259
SwissProt Accessions	Q8N8V4	Gene names	ANKS4B, HARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

TBCD4_MOUSE
θ value	3.77169e-06 (rank : 181)	NC score	0.092612 (rank : 336)
Query Neighborhood Hits	453	Target Neighborhood Hits	276	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BYJ6, Q5DU23, Q66JU2, Q6P2M2, Q8BMH6, Q8BXM2	Gene names	Tbc1d4, Kiaa0603
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160).

IKBB_HUMAN
θ value	6.43352e-06 (rank : 182)	NC score	0.767818 (rank : 127)
Query Neighborhood Hits	453	Target Neighborhood Hits	284	Shared Neighborhood Hits	272
SwissProt Accessions	Q15653, Q96BJ7	Gene names	NFKBIB, IKBB, TRIP9
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9).

KRIT1_MOUSE
θ value	6.43352e-06 (rank : 183)	NC score	0.693816 (rank : 167)
Query Neighborhood Hits	453	Target Neighborhood Hits	258	Shared Neighborhood Hits	229
SwissProt Accessions	Q6S5J6, Q6VSV2, Q7TPR8, Q8C9Q6, Q9EPY2, Q9ERH0	Gene names	Krit1, Ccm1
Domain Architecture	No domain graphic available
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog).

NFKB2_HUMAN
θ value	6.43352e-06 (rank : 184)	NC score	0.705172 (rank : 162)
Query Neighborhood Hits	453	Target Neighborhood Hits	325	Shared Neighborhood Hits	278
SwissProt Accessions	Q00653, Q04860, Q9BU75, Q9H471, Q9H472	Gene names	NFKB2, LYT10
Domain Architecture
Description	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10) (Oncogene Lyt-10) (Lyt10) [Contains: Nuclear factor NF-kappa-B p52 subunit].

ANR19_HUMAN
θ value	8.40245e-06 (rank : 185)	NC score	0.746434 (rank : 140)
Query Neighborhood Hits	453	Target Neighborhood Hits	276	Shared Neighborhood Hits	271
SwissProt Accessions	Q9H560	Gene names	ANKRD19
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 19.

ANR25_MOUSE
θ value	8.40245e-06 (rank : 186)	NC score	0.666114 (rank : 177)
Query Neighborhood Hits	453	Target Neighborhood Hits	398	Shared Neighborhood Hits	263
SwissProt Accessions	Q8BX02, Q8BLD5, Q91Z35	Gene names	Ankrd25
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25.

GLSL_HUMAN
θ value	8.40245e-06 (rank : 187)	NC score	0.543997 (rank : 215)
Query Neighborhood Hits	453	Target Neighborhood Hits	211	Shared Neighborhood Hits	203
SwissProt Accessions	Q9UI32, Q9NYY2, Q9UI31	Gene names	GLS2, GA
Domain Architecture
Description	Glutaminase liver isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (L-glutaminase).

KRIT1_HUMAN
θ value	8.40245e-06 (rank : 188)	NC score	0.681697 (rank : 173)
Query Neighborhood Hits	453	Target Neighborhood Hits	258	Shared Neighborhood Hits	222
SwissProt Accessions	O00522, O43894, Q506L6, Q6U276, Q75N19, Q9H180, Q9H264, Q9HAX5	Gene names	KRIT1, CCM1
Domain Architecture
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein).

SNCAP_HUMAN
θ value	8.40245e-06 (rank : 189)	NC score	0.724046 (rank : 153)
Query Neighborhood Hits	453	Target Neighborhood Hits	313	Shared Neighborhood Hits	239
SwissProt Accessions	Q9Y6H5	Gene names	SNCAIP
Domain Architecture
Description	Synphilin-1 (Alpha-synuclein-interacting protein).

ACBD6_MOUSE
θ value	1.43324e-05 (rank : 190)	NC score	0.775181 (rank : 125)
Query Neighborhood Hits	453	Target Neighborhood Hits	305	Shared Neighborhood Hits	288
SwissProt Accessions	Q9D061, Q3TMN7, Q9DCU4	Gene names	Acbd6
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 6.

ANR25_HUMAN
θ value	1.43324e-05 (rank : 191)	NC score	0.679620 (rank : 174)
Query Neighborhood Hits	453	Target Neighborhood Hits	350	Shared Neighborhood Hits	263
SwissProt Accessions	Q63ZY3, Q3KQZ3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210	Gene names	ANKRD25, KIAA1518, SIP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25 (SRC-1-interacting protein) (SRC1-interacting protein).

ANR33_MOUSE
θ value	1.43324e-05 (rank : 192)	NC score	0.681971 (rank : 172)
Query Neighborhood Hits	453	Target Neighborhood Hits	225	Shared Neighborhood Hits	222
SwissProt Accessions	Q8BXP5, Q8BXP4, Q8R1Z1	Gene names	Ankrd33
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

ANR37_MOUSE
θ value	1.43324e-05 (rank : 193)	NC score	0.719171 (rank : 154)
Query Neighborhood Hits	453	Target Neighborhood Hits	237	Shared Neighborhood Hits	237
SwissProt Accessions	Q569N2, Q8CHS0	Gene names	Ankrd37
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37.

BCOR_HUMAN
θ value	1.43324e-05 (rank : 194)	NC score	0.689971 (rank : 170)
Query Neighborhood Hits	453	Target Neighborhood Hits	609	Shared Neighborhood Hits	290
SwissProt Accessions	Q6W2J9, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2	Gene names	BCOR, KIAA1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

TEX14_HUMAN
θ value	1.43324e-05 (rank : 195)	NC score	0.416474 (rank : 253)
Query Neighborhood Hits	453	Target Neighborhood Hits	1103	Shared Neighborhood Hits	279
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

USH1G_HUMAN
θ value	1.43324e-05 (rank : 196)	NC score	0.756529 (rank : 134)
Query Neighborhood Hits	453	Target Neighborhood Hits	267	Shared Neighborhood Hits	260
SwissProt Accessions	Q495M9, Q8N251	Gene names	USH1G, SANS
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein (Scaffold protein containing ankyrin repeats and SAM domain).

USH1G_MOUSE
θ value	1.43324e-05 (rank : 197)	NC score	0.756362 (rank : 135)
Query Neighborhood Hits	453	Target Neighborhood Hits	271	Shared Neighborhood Hits	261
SwissProt Accessions	Q80T11, Q80UG0	Gene names	Ush1g, Sans
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein homolog (Scaffold protein containing ankyrin repeats and SAM domain) (Jackson shaker protein).

ANR26_MOUSE
θ value	1.87187e-05 (rank : 198)	NC score	0.445175 (rank : 248)
Query Neighborhood Hits	453	Target Neighborhood Hits	1554	Shared Neighborhood Hits	306
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

BCOR_MOUSE
θ value	1.87187e-05 (rank : 199)	NC score	0.699096 (rank : 165)
Query Neighborhood Hits	453	Target Neighborhood Hits	521	Shared Neighborhood Hits	286
SwissProt Accessions	Q8CGN4, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3	Gene names	Bcor, Kiaa1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

CENB1_HUMAN
θ value	1.87187e-05 (rank : 200)	NC score	0.521548 (rank : 225)
Query Neighborhood Hits	453	Target Neighborhood Hits	383	Shared Neighborhood Hits	260
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

SHC2_MOUSE
θ value	2.44474e-05 (rank : 201)	NC score	0.107106 (rank : 327)
Query Neighborhood Hits	453	Target Neighborhood Hits	144	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

ACBD6_HUMAN
θ value	3.19293e-05 (rank : 202)	NC score	0.767575 (rank : 128)
Query Neighborhood Hits	453	Target Neighborhood Hits	304	Shared Neighborhood Hits	285
SwissProt Accessions	Q9BR61	Gene names	ACBD6
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 6.

EPHB3_HUMAN
θ value	3.19293e-05 (rank : 203)	NC score	0.088332 (rank : 340)
Query Neighborhood Hits	453	Target Neighborhood Hits	996	Shared Neighborhood Hits	67
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

IKBE_MOUSE
θ value	3.19293e-05 (rank : 204)	NC score	0.786769 (rank : 120)
Query Neighborhood Hits	453	Target Neighborhood Hits	308	Shared Neighborhood Hits	273
SwissProt Accessions	O54910, Q3U686, Q9CZZ9, Q9D7U3	Gene names	Nfkbie, Ikbe
Domain Architecture
Description	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKB-E).

TRPV6_MOUSE
θ value	3.19293e-05 (rank : 205)	NC score	0.544195 (rank : 214)
Query Neighborhood Hits	453	Target Neighborhood Hits	284	Shared Neighborhood Hits	253
SwissProt Accessions	Q91WD2	Gene names	Trpv6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1).

A20A1_HUMAN
θ value	4.1701e-05 (rank : 206)	NC score	0.636340 (rank : 188)
Query Neighborhood Hits	453	Target Neighborhood Hits	698	Shared Neighborhood Hits	284
SwissProt Accessions	Q5TYW2, Q9H0H6	Gene names	ANKRD20A1, ANKRD20A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A1.

A20A3_HUMAN
θ value	4.1701e-05 (rank : 207)	NC score	0.637871 (rank : 186)
Query Neighborhood Hits	453	Target Neighborhood Hits	692	Shared Neighborhood Hits	287
SwissProt Accessions	Q5VUR7	Gene names	ANKRD20A3
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A3.

A20A4_HUMAN
θ value	4.1701e-05 (rank : 208)	NC score	0.633281 (rank : 191)
Query Neighborhood Hits	453	Target Neighborhood Hits	710	Shared Neighborhood Hits	287
SwissProt Accessions	Q5SQ80	Gene names	ANKRD20A4
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A4.

ANKY2_MOUSE
θ value	4.1701e-05 (rank : 209)	NC score	0.709795 (rank : 160)
Query Neighborhood Hits	453	Target Neighborhood Hits	316	Shared Neighborhood Hits	265
SwissProt Accessions	Q3TPE9, Q8BK14, Q8BYW5, Q8R3N4, Q921J1	Gene names	Ankmy2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and MYND domain-containing protein 2.

ANR26_HUMAN
θ value	4.1701e-05 (rank : 210)	NC score	0.425928 (rank : 252)
Query Neighborhood Hits	453	Target Neighborhood Hits	1614	Shared Neighborhood Hits	314
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

ANR45_HUMAN
θ value	4.1701e-05 (rank : 211)	NC score	0.600729 (rank : 197)
Query Neighborhood Hits	453	Target Neighborhood Hits	201	Shared Neighborhood Hits	185
SwissProt Accessions	Q5TZF3, Q6ZST1	Gene names	ANKRD45
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 45.

SHC1_HUMAN
θ value	4.1701e-05 (rank : 212)	NC score	0.103676 (rank : 332)
Query Neighborhood Hits	453	Target Neighborhood Hits	170	Shared Neighborhood Hits	20
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	4.1701e-05 (rank : 213)	NC score	0.102864 (rank : 334)
Query Neighborhood Hits	453	Target Neighborhood Hits	180	Shared Neighborhood Hits	19
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	4.1701e-05 (rank : 214)	NC score	0.106880 (rank : 328)
Query Neighborhood Hits	453	Target Neighborhood Hits	170	Shared Neighborhood Hits	19
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC3_HUMAN
θ value	4.1701e-05 (rank : 215)	NC score	0.104159 (rank : 330)
Query Neighborhood Hits	453	Target Neighborhood Hits	155	Shared Neighborhood Hits	16
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	4.1701e-05 (rank : 216)	NC score	0.103837 (rank : 331)
Query Neighborhood Hits	453	Target Neighborhood Hits	151	Shared Neighborhood Hits	17
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

ANR41_HUMAN
θ value	5.44631e-05 (rank : 217)	NC score	0.748829 (rank : 137)
Query Neighborhood Hits	453	Target Neighborhood Hits	332	Shared Neighborhood Hits	256
SwissProt Accessions	Q8NAG6, Q8N8J8	Gene names	ANKRD41
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 41.

ANR46_HUMAN
θ value	5.44631e-05 (rank : 218)	NC score	0.794352 (rank : 116)
Query Neighborhood Hits	453	Target Neighborhood Hits	281	Shared Neighborhood Hits	272
SwissProt Accessions	Q86W74, Q6P9B7	Gene names	ANKRD46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

ASPP2_HUMAN
θ value	5.44631e-05 (rank : 219)	NC score	0.554051 (rank : 212)
Query Neighborhood Hits	453	Target Neighborhood Hits	1156	Shared Neighborhood Hits	291
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

NUD12_MOUSE
θ value	5.44631e-05 (rank : 220)	NC score	0.581889 (rank : 204)
Query Neighborhood Hits	453	Target Neighborhood Hits	243	Shared Neighborhood Hits	223
SwissProt Accessions	Q9DCN1, Q6PFA5	Gene names	Nudt12
Domain Architecture	No domain graphic available
Description	Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12).

TEX14_MOUSE
θ value	5.44631e-05 (rank : 221)	NC score	0.415431 (rank : 254)
Query Neighborhood Hits	453	Target Neighborhood Hits	1333	Shared Neighborhood Hits	292
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

DAB2_HUMAN
θ value	7.1131e-05 (rank : 222)	NC score	0.115379 (rank : 321)
Query Neighborhood Hits	453	Target Neighborhood Hits	197	Shared Neighborhood Hits	22
SwissProt Accessions	P98082, Q13598, Q9BTY0, Q9UK04	Gene names	DAB2, DOC2
Domain Architecture
Description	Disabled homolog 2 (Differentially expressed protein 2) (DOC-2).

POT14_HUMAN
θ value	9.29e-05 (rank : 223)	NC score	0.691959 (rank : 168)
Query Neighborhood Hits	453	Target Neighborhood Hits	403	Shared Neighborhood Hits	273
SwissProt Accessions	Q6S5H5, Q6S5H6, Q6S8J2	Gene names	POTE14
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 14.

A20A2_HUMAN
θ value	0.000121331 (rank : 224)	NC score	0.636500 (rank : 187)
Query Neighborhood Hits	453	Target Neighborhood Hits	716	Shared Neighborhood Hits	286
SwissProt Accessions	Q4UJ75	Gene names	ANKRD20A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A2.

ANKY2_HUMAN
θ value	0.000121331 (rank : 225)	NC score	0.730831 (rank : 152)
Query Neighborhood Hits	453	Target Neighborhood Hits	306	Shared Neighborhood Hits	265
SwissProt Accessions	Q8IV38, Q96BL3	Gene names	ANKMY2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and MYND domain-containing protein 2.

ANS4B_MOUSE
θ value	0.000121331 (rank : 226)	NC score	0.734246 (rank : 149)
Query Neighborhood Hits	453	Target Neighborhood Hits	294	Shared Neighborhood Hits	256
SwissProt Accessions	Q8K3X6, Q9D8A5	Gene names	Anks4b, Harp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

ASPP1_HUMAN
θ value	0.000121331 (rank : 227)	NC score	0.539802 (rank : 218)
Query Neighborhood Hits	453	Target Neighborhood Hits	956	Shared Neighborhood Hits	289
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_MOUSE
θ value	0.000121331 (rank : 228)	NC score	0.521694 (rank : 224)
Query Neighborhood Hits	453	Target Neighborhood Hits	1244	Shared Neighborhood Hits	292
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

SAMN1_HUMAN
θ value	0.000121331 (rank : 229)	NC score	0.145144 (rank : 311)
Query Neighborhood Hits	453	Target Neighborhood Hits	74	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

CLPB_HUMAN
θ value	0.000158464 (rank : 230)	NC score	0.590483 (rank : 200)
Query Neighborhood Hits	453	Target Neighborhood Hits	265	Shared Neighborhood Hits	238
SwissProt Accessions	Q9H078, Q8ND11, Q9H8Y0	Gene names	CLPB, SKD3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

EPHA2_HUMAN
θ value	0.000158464 (rank : 231)	NC score	0.086791 (rank : 346)
Query Neighborhood Hits	453	Target Neighborhood Hits	1021	Shared Neighborhood Hits	68
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

TBCD4_HUMAN
θ value	0.000158464 (rank : 232)	NC score	0.084473 (rank : 359)
Query Neighborhood Hits	453	Target Neighborhood Hits	357	Shared Neighborhood Hits	36
SwissProt Accessions	O60343, Q5W0B9	Gene names	TBC1D4, KIAA0603
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160).

ANKY1_HUMAN
θ value	0.00020696 (rank : 233)	NC score	0.566648 (rank : 209)
Query Neighborhood Hits	453	Target Neighborhood Hits	248	Shared Neighborhood Hits	203
SwissProt Accessions	Q9P2S6, Q8IYX5, Q8NDK5, Q9NX10	Gene names	ANKMY1, TSAL1, ZMYND13
Domain Architecture
Description	Ankyrin repeat and MYND domain-containing protein 1 (Testis-specific ankyrin-like protein 1) (Zinc-finger MYND domain-containing protein 13).

ANR32_MOUSE
θ value	0.00020696 (rank : 234)	NC score	0.747456 (rank : 139)
Query Neighborhood Hits	453	Target Neighborhood Hits	285	Shared Neighborhood Hits	262
SwissProt Accessions	Q8R3P9, Q5XK30, Q8BHY5, Q921Y9	Gene names	Ankrd32
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 32.

ANR38_MOUSE
θ value	0.00020696 (rank : 235)	NC score	0.633820 (rank : 190)
Query Neighborhood Hits	453	Target Neighborhood Hits	512	Shared Neighborhood Hits	243
SwissProt Accessions	Q6P9J5, Q8BV03	Gene names	Ankrd38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

CENB2_HUMAN
θ value	0.00020696 (rank : 236)	NC score	0.516674 (rank : 227)
Query Neighborhood Hits	453	Target Neighborhood Hits	425	Shared Neighborhood Hits	258
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

EPHB3_MOUSE
θ value	0.00020696 (rank : 237)	NC score	0.086808 (rank : 345)
Query Neighborhood Hits	453	Target Neighborhood Hits	996	Shared Neighborhood Hits	64
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

LRRK1_MOUSE
θ value	0.00020696 (rank : 238)	NC score	0.127399 (rank : 314)
Query Neighborhood Hits	453	Target Neighborhood Hits	1267	Shared Neighborhood Hits	154
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

SASH1_MOUSE
θ value	0.00020696 (rank : 239)	NC score	0.150638 (rank : 304)
Query Neighborhood Hits	453	Target Neighborhood Hits	263	Shared Neighborhood Hits	51
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

ANR46_MOUSE
θ value	0.000270298 (rank : 240)	NC score	0.787519 (rank : 119)
Query Neighborhood Hits	453	Target Neighborhood Hits	274	Shared Neighborhood Hits	266
SwissProt Accessions	Q8BTZ5, Q1LZK9, Q8BV97	Gene names	Ankrd46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

DDFL1_MOUSE
θ value	0.000270298 (rank : 241)	NC score	0.456111 (rank : 244)
Query Neighborhood Hits	453	Target Neighborhood Hits	324	Shared Neighborhood Hits	254
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

EPHA2_MOUSE
θ value	0.000270298 (rank : 242)	NC score	0.086977 (rank : 344)
Query Neighborhood Hits	453	Target Neighborhood Hits	1020	Shared Neighborhood Hits	67
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

GLSK_HUMAN
θ value	0.000270298 (rank : 243)	NC score	0.498811 (rank : 231)
Query Neighborhood Hits	453	Target Neighborhood Hits	204	Shared Neighborhood Hits	190
SwissProt Accessions	O94925, Q9UL05, Q9UL06, Q9UL07, Q9UN40	Gene names	GLS, GLS1, KIAA0838
Domain Architecture
Description	Glutaminase kidney isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (K-glutaminase).

HECD1_HUMAN
θ value	0.000270298 (rank : 244)	NC score	0.588914 (rank : 201)
Query Neighborhood Hits	453	Target Neighborhood Hits	371	Shared Neighborhood Hits	270
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

ANR37_HUMAN
θ value	0.00035302 (rank : 245)	NC score	0.733180 (rank : 150)
Query Neighborhood Hits	453	Target Neighborhood Hits	247	Shared Neighborhood Hits	246
SwissProt Accessions	Q7Z713	Gene names	ANKRD37, LPR2BP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37 (Low-density lipoprotein receptor-related protein 2-binding protein) (hLrp2bp).

ANR45_MOUSE
θ value	0.00035302 (rank : 246)	NC score	0.635273 (rank : 189)
Query Neighborhood Hits	453	Target Neighborhood Hits	204	Shared Neighborhood Hits	190
SwissProt Accessions	Q810N6	Gene names	Ankrd45
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 45.

CENB5_HUMAN
θ value	0.00035302 (rank : 247)	NC score	0.525614 (rank : 222)
Query Neighborhood Hits	453	Target Neighborhood Hits	395	Shared Neighborhood Hits	265
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

MPP8_HUMAN
θ value	0.00035302 (rank : 248)	NC score	0.651933 (rank : 181)
Query Neighborhood Hits	453	Target Neighborhood Hits	948	Shared Neighborhood Hits	267
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

SASH1_HUMAN
θ value	0.00035302 (rank : 249)	NC score	0.149689 (rank : 307)
Query Neighborhood Hits	453	Target Neighborhood Hits	292	Shared Neighborhood Hits	61
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

AN13A_HUMAN
θ value	0.000461057 (rank : 250)	NC score	0.465005 (rank : 240)
Query Neighborhood Hits	453	Target Neighborhood Hits	243	Shared Neighborhood Hits	225
SwissProt Accessions	Q8IZ07, O60736	Gene names	ANKRD13A, ANKRD13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13A (Protein KE03).

JIP1_MOUSE
θ value	0.000461057 (rank : 251)	NC score	0.113969 (rank : 325)
Query Neighborhood Hits	453	Target Neighborhood Hits	259	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

AN13C_HUMAN
θ value	0.000602161 (rank : 252)	NC score	0.519524 (rank : 226)
Query Neighborhood Hits	453	Target Neighborhood Hits	241	Shared Neighborhood Hits	234
SwissProt Accessions	Q8N6S4, Q5VYH4, Q5VYH5, Q6PJE4, Q9H0N9	Gene names	ANKRD13C
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13C.

ANR38_HUMAN
θ value	0.000602161 (rank : 253)	NC score	0.660876 (rank : 180)
Query Neighborhood Hits	453	Target Neighborhood Hits	443	Shared Neighborhood Hits	241
SwissProt Accessions	Q5T7N3, Q6P9A0, Q86T71, Q86VE6, Q8NAX3	Gene names	ANKRD38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

APBA3_MOUSE
θ value	0.000602161 (rank : 254)	NC score	0.076758 (rank : 374)
Query Neighborhood Hits	453	Target Neighborhood Hits	174	Shared Neighborhood Hits	19
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

EPHA5_HUMAN
θ value	0.000602161 (rank : 255)	NC score	0.088914 (rank : 339)
Query Neighborhood Hits	453	Target Neighborhood Hits	1009	Shared Neighborhood Hits	72
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

LRRK1_HUMAN
θ value	0.000602161 (rank : 256)	NC score	0.103299 (rank : 333)
Query Neighborhood Hits	453	Target Neighborhood Hits	1237	Shared Neighborhood Hits	128
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

MTPN_HUMAN
θ value	0.000786445 (rank : 257)	NC score	0.804368 (rank : 106)
Query Neighborhood Hits	453	Target Neighborhood Hits	269	Shared Neighborhood Hits	269
SwissProt Accessions	P58546	Gene names	MTPN
Domain Architecture
Description	Myotrophin (Protein V-1).

MTPN_MOUSE
θ value	0.000786445 (rank : 258)	NC score	0.807501 (rank : 96)
Query Neighborhood Hits	453	Target Neighborhood Hits	269	Shared Neighborhood Hits	269
SwissProt Accessions	P62774, P80144, Q543M6, Q9DCN8	Gene names	Mtpn, Gcdp
Domain Architecture	No domain graphic available
Description	Myotrophin (Protein V-1) (Granule cell differentiation protein).

POT22_HUMAN
θ value	0.000786445 (rank : 259)	NC score	0.650991 (rank : 182)
Query Neighborhood Hits	453	Target Neighborhood Hits	266	Shared Neighborhood Hits	256
SwissProt Accessions	Q6S545	Gene names	ACTBL1, POTE22
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 22.

ANR32_HUMAN
θ value	0.00102713 (rank : 260)	NC score	0.754625 (rank : 136)
Query Neighborhood Hits	453	Target Neighborhood Hits	270	Shared Neighborhood Hits	261
SwissProt Accessions	Q9BQI6	Gene names	ANKRD32
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 32.

APBA1_HUMAN
θ value	0.00102713 (rank : 261)	NC score	0.074191 (rank : 378)
Query Neighborhood Hits	453	Target Neighborhood Hits	325	Shared Neighborhood Hits	25
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

APBA2_HUMAN
θ value	0.00102713 (rank : 262)	NC score	0.075532 (rank : 377)
Query Neighborhood Hits	453	Target Neighborhood Hits	220	Shared Neighborhood Hits	21
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

CD2A1_HUMAN
θ value	0.00102713 (rank : 263)	NC score	0.619571 (rank : 193)
Query Neighborhood Hits	453	Target Neighborhood Hits	196	Shared Neighborhood Hits	194
SwissProt Accessions	P42771, O95440, Q15191, Q5VVJ5, Q96B52, Q9NP05	Gene names	CDKN2A, CDKN2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4) (p16-INK4a) (p16INK4A) (Multiple tumor suppressor 1) (MTS1).

CT012_MOUSE
θ value	0.00102713 (rank : 264)	NC score	0.476371 (rank : 235)
Query Neighborhood Hits	453	Target Neighborhood Hits	229	Shared Neighborhood Hits	182
SwissProt Accessions	Q8C008, Q8C060	Gene names
Domain Architecture	No domain graphic available
Description	Protein C20orf12 homolog.

DAB1_HUMAN
θ value	0.00102713 (rank : 265)	NC score	0.115372 (rank : 322)
Query Neighborhood Hits	453	Target Neighborhood Hits	219	Shared Neighborhood Hits	25
SwissProt Accessions	O75553, Q9NYA8	Gene names	DAB1
Domain Architecture
Description	Disabled homolog 1.

DAB1_MOUSE
θ value	0.00102713 (rank : 266)	NC score	0.115673 (rank : 318)
Query Neighborhood Hits	453	Target Neighborhood Hits	145	Shared Neighborhood Hits	22
SwissProt Accessions	P97318, P97316, P97317	Gene names	Dab1
Domain Architecture
Description	Disabled homolog 1.

EPHA1_MOUSE
θ value	0.00102713 (rank : 267)	NC score	0.087114 (rank : 343)
Query Neighborhood Hits	453	Target Neighborhood Hits	958	Shared Neighborhood Hits	64
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHA6_HUMAN
θ value	0.00102713 (rank : 268)	NC score	0.089796 (rank : 337)
Query Neighborhood Hits	453	Target Neighborhood Hits	959	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHB2_HUMAN
θ value	0.00102713 (rank : 269)	NC score	0.086788 (rank : 347)
Query Neighborhood Hits	453	Target Neighborhood Hits	983	Shared Neighborhood Hits	66
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

TRPV5_HUMAN
θ value	0.00102713 (rank : 270)	NC score	0.457219 (rank : 242)
Query Neighborhood Hits	453	Target Neighborhood Hits	261	Shared Neighborhood Hits	224
SwissProt Accessions	Q9NQA5, Q8NDW5, Q8NDX7, Q8NDX8, Q96PM6	Gene names	TRPV5, ECAC1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Calcium transport protein 2) (CaT2).

DAB2_MOUSE
θ value	0.00134147 (rank : 271)	NC score	0.115649 (rank : 319)
Query Neighborhood Hits	453	Target Neighborhood Hits	163	Shared Neighborhood Hits	21
SwissProt Accessions	P98078, Q3U3K1, Q91W56, Q923E1	Gene names	Dab2, Doc2
Domain Architecture
Description	Disabled homolog 2 (DOC-2) (Mitogen-responsive phosphoprotein).

NUD12_HUMAN
θ value	0.00134147 (rank : 272)	NC score	0.550572 (rank : 213)
Query Neighborhood Hits	453	Target Neighborhood Hits	222	Shared Neighborhood Hits	203
SwissProt Accessions	Q9BQG2, Q8TAL7	Gene names	NUDT12
Domain Architecture	No domain graphic available
Description	Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12).

ANR43_MOUSE
θ value	0.00175202 (rank : 273)	NC score	0.603263 (rank : 194)
Query Neighborhood Hits	453	Target Neighborhood Hits	214	Shared Neighborhood Hits	205
SwissProt Accessions	Q8BLS7	Gene names	Ankrd43
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 43.

CDN2B_MOUSE
θ value	0.00175202 (rank : 274)	NC score	0.650911 (rank : 183)
Query Neighborhood Hits	453	Target Neighborhood Hits	201	Shared Neighborhood Hits	199
SwissProt Accessions	P55271	Gene names	Cdkn2b
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b).

EPHA8_MOUSE
θ value	0.00175202 (rank : 275)	NC score	0.086662 (rank : 350)
Query Neighborhood Hits	453	Target Neighborhood Hits	969	Shared Neighborhood Hits	63
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

JIP1_HUMAN
θ value	0.00175202 (rank : 276)	NC score	0.113727 (rank : 326)
Query Neighborhood Hits	453	Target Neighborhood Hits	271	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP2_HUMAN
θ value	0.00175202 (rank : 277)	NC score	0.096389 (rank : 335)
Query Neighborhood Hits	453	Target Neighborhood Hits	288	Shared Neighborhood Hits	37
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JIP2_MOUSE
θ value	0.00175202 (rank : 278)	NC score	0.089174 (rank : 338)
Query Neighborhood Hits	453	Target Neighborhood Hits	144	Shared Neighborhood Hits	21
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

TRPC6_HUMAN
θ value	0.00175202 (rank : 279)	NC score	0.149770 (rank : 306)
Query Neighborhood Hits	453	Target Neighborhood Hits	171	Shared Neighborhood Hits	104
SwissProt Accessions	Q9Y210, Q9HCW3, Q9NQA8, Q9NQA9	Gene names	TRPC6, TRP6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6).

CLPB_MOUSE
θ value	0.00228821 (rank : 280)	NC score	0.667165 (rank : 176)
Query Neighborhood Hits	453	Target Neighborhood Hits	289	Shared Neighborhood Hits	250
SwissProt Accessions	Q60649	Gene names	Clpb, Skd3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

EPHA7_HUMAN
θ value	0.00228821 (rank : 281)	NC score	0.087320 (rank : 342)
Query Neighborhood Hits	453	Target Neighborhood Hits	1053	Shared Neighborhood Hits	71
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHB2_MOUSE
θ value	0.00228821 (rank : 282)	NC score	0.085455 (rank : 358)
Query Neighborhood Hits	453	Target Neighborhood Hits	982	Shared Neighborhood Hits	66
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

IASPP_MOUSE
θ value	0.00228821 (rank : 283)	NC score	0.487522 (rank : 234)
Query Neighborhood Hits	453	Target Neighborhood Hits	1024	Shared Neighborhood Hits	274
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

TRPC6_MOUSE
θ value	0.00228821 (rank : 284)	NC score	0.123035 (rank : 316)
Query Neighborhood Hits	453	Target Neighborhood Hits	171	Shared Neighborhood Hits	91
SwissProt Accessions	Q61143, Q9Z2J1	Gene names	Trpc6, Trp6, Trrp6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6) (Calcium entry channel).

EPHA1_HUMAN
θ value	0.00298849 (rank : 285)	NC score	0.086743 (rank : 348)
Query Neighborhood Hits	453	Target Neighborhood Hits	997	Shared Neighborhood Hits	69
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHA6_MOUSE
θ value	0.00298849 (rank : 286)	NC score	0.088254 (rank : 341)
Query Neighborhood Hits	453	Target Neighborhood Hits	946	Shared Neighborhood Hits	62
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

IASPP_HUMAN
θ value	0.00298849 (rank : 287)	NC score	0.539519 (rank : 219)
Query Neighborhood Hits	453	Target Neighborhood Hits	688	Shared Neighborhood Hits	270
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

LIPB1_MOUSE
θ value	0.00298849 (rank : 288)	NC score	0.071314 (rank : 383)
Query Neighborhood Hits	453	Target Neighborhood Hits	727	Shared Neighborhood Hits	51
SwissProt Accessions	Q8C8U0, Q69ZN5, Q6GQV3, Q80VB4, Q9CUT7	Gene names	Ppfibp1, Kiaa1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1).

ABTB2_MOUSE
θ value	0.00390308 (rank : 289)	NC score	0.560454 (rank : 211)
Query Neighborhood Hits	453	Target Neighborhood Hits	414	Shared Neighborhood Hits	241
SwissProt Accessions	Q7TQI7	Gene names	Abtb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

EPHA5_MOUSE
θ value	0.00390308 (rank : 290)	NC score	0.080869 (rank : 371)
Query Neighborhood Hits	453	Target Neighborhood Hits	950	Shared Neighborhood Hits	66
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

EPHA8_HUMAN
θ value	0.00390308 (rank : 291)	NC score	0.084432 (rank : 361)
Query Neighborhood Hits	453	Target Neighborhood Hits	956	Shared Neighborhood Hits	63
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

TRPC3_MOUSE
θ value	0.00390308 (rank : 292)	NC score	0.121818 (rank : 317)
Query Neighborhood Hits	453	Target Neighborhood Hits	131	Shared Neighborhood Hits	79
SwissProt Accessions	Q9QZC1, Q61058	Gene names	Trpc3, Trp3, Trrp3
Domain Architecture
Description	Short transient receptor potential channel 3 (TrpC3) (Transient receptor protein 3) (Mtrp3) (Receptor-activated cation channel TRP3) (trp-related protein 3).

AN13A_MOUSE
θ value	0.00509761 (rank : 293)	NC score	0.433808 (rank : 250)
Query Neighborhood Hits	453	Target Neighborhood Hits	226	Shared Neighborhood Hits	216
SwissProt Accessions	Q80UP5, Q2VPQ7, Q6P7F2	Gene names	Ankrd13a, Ankrd13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13A.

ANR33_HUMAN
θ value	0.00509761 (rank : 294)	NC score	0.661936 (rank : 178)
Query Neighborhood Hits	453	Target Neighborhood Hits	215	Shared Neighborhood Hits	212
SwissProt Accessions	Q7Z3H0, Q5K619, Q5K621, Q5K622, Q5K623, Q5K624, Q6ZUN0	Gene names	ANKRD33, C12orf7
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

APBA2_MOUSE
θ value	0.00509761 (rank : 295)	NC score	0.069842 (rank : 384)
Query Neighborhood Hits	453	Target Neighborhood Hits	219	Shared Neighborhood Hits	19
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

CT086_HUMAN
θ value	0.00509761 (rank : 296)	NC score	0.794620 (rank : 115)
Query Neighborhood Hits	453	Target Neighborhood Hits	277	Shared Neighborhood Hits	270
SwissProt Accessions	Q9BZ19, Q4VXE6	Gene names	C20orf86
Domain Architecture
Description	Putative uncharacterized protein C20orf86.

DDEF1_MOUSE
θ value	0.00509761 (rank : 297)	NC score	0.290686 (rank : 279)
Query Neighborhood Hits	453	Target Neighborhood Hits	592	Shared Neighborhood Hits	202
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

EPHA7_MOUSE
θ value	0.00509761 (rank : 298)	NC score	0.086614 (rank : 352)
Query Neighborhood Hits	453	Target Neighborhood Hits	1025	Shared Neighborhood Hits	69
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

TRPV6_HUMAN
θ value	0.00509761 (rank : 299)	NC score	0.460990 (rank : 241)
Query Neighborhood Hits	453	Target Neighborhood Hits	262	Shared Neighborhood Hits	226
SwissProt Accessions	Q9H1D0, Q8TDL3, Q8WXR8, Q96LC5, Q9H1D1, Q9H296	Gene names	TRPV6, ECAC2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1) (CaT-like) (CaT-L).

CD2A1_MOUSE
θ value	0.00665767 (rank : 300)	NC score	0.690198 (rank : 169)
Query Neighborhood Hits	453	Target Neighborhood Hits	206	Shared Neighborhood Hits	202
SwissProt Accessions	P51480, O89088, P97510, P97937, Q6PEA2, Q78E39, Q78E57, Q792X7, Q9QWH6, Q9QWH7, Q9QWH8	Gene names	Cdkn2a, P16ink4a
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 2A, isoforms 1/2 (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4) (p16-INK4a).

EPHB1_HUMAN
θ value	0.00665767 (rank : 301)	NC score	0.084035 (rank : 362)
Query Neighborhood Hits	453	Target Neighborhood Hits	988	Shared Neighborhood Hits	68
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

LIPB1_HUMAN
θ value	0.00665767 (rank : 302)	NC score	0.076389 (rank : 376)
Query Neighborhood Hits	453	Target Neighborhood Hits	640	Shared Neighborhood Hits	52
SwissProt Accessions	Q86W92, O75336, Q86X70, Q9NY03, Q9ULJ0	Gene names	PPFIBP1, KIAA1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2).

LIPB2_MOUSE
θ value	0.00665767 (rank : 303)	NC score	0.082266 (rank : 366)
Query Neighborhood Hits	453	Target Neighborhood Hits	570	Shared Neighborhood Hits	43
SwissProt Accessions	O35711, Q7TMG4, Q8CBS6, Q99KX6	Gene names	Ppfibp2, Cclp1
Domain Architecture
Description	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) (Coiled-coil-like protein 1).

TBCD1_MOUSE
θ value	0.00665767 (rank : 304)	NC score	0.073809 (rank : 380)
Query Neighborhood Hits	453	Target Neighborhood Hits	241	Shared Neighborhood Hits	21
SwissProt Accessions	Q60949, Q80TJ9, Q923F8	Gene names	Tbc1d1, Kiaa1108, Tbc1
Domain Architecture
Description	TBC1 domain family member 1.

TRPC3_HUMAN
θ value	0.00665767 (rank : 305)	NC score	0.129801 (rank : 313)
Query Neighborhood Hits	453	Target Neighborhood Hits	137	Shared Neighborhood Hits	83
SwissProt Accessions	Q13507, O00593, Q15660	Gene names	TRPC3, TRP3
Domain Architecture
Description	Short transient receptor potential channel 3 (TrpC3) (Htrp-3) (Htrp3).

ABTB2_HUMAN
θ value	0.00869519 (rank : 306)	NC score	0.571344 (rank : 207)
Query Neighborhood Hits	453	Target Neighborhood Hits	391	Shared Neighborhood Hits	240
SwissProt Accessions	Q8N961, Q6MZW4, Q8NB44	Gene names	ABTB2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

AN36A_HUMAN
θ value	0.00869519 (rank : 307)	NC score	0.739173 (rank : 144)
Query Neighborhood Hits	453	Target Neighborhood Hits	271	Shared Neighborhood Hits	267
SwissProt Accessions	Q6UX02, Q86X62	Gene names	ANKRD36, ANKRD36A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 36A.

ANR40_HUMAN
θ value	0.00869519 (rank : 308)	NC score	0.582497 (rank : 203)
Query Neighborhood Hits	453	Target Neighborhood Hits	224	Shared Neighborhood Hits	204
SwissProt Accessions	Q6AI12, Q96E32	Gene names	ANKRD40
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 40.

ANR40_MOUSE
θ value	0.00869519 (rank : 309)	NC score	0.578701 (rank : 206)
Query Neighborhood Hits	453	Target Neighborhood Hits	228	Shared Neighborhood Hits	208
SwissProt Accessions	Q5SUE8, Q8R595, Q9CU71	Gene names	Ankrd40
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 40.

EPHB4_MOUSE
θ value	0.00869519 (rank : 310)	NC score	0.085470 (rank : 357)
Query Neighborhood Hits	453	Target Neighborhood Hits	1013	Shared Neighborhood Hits	68
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

TBCD1_HUMAN
θ value	0.00869519 (rank : 311)	NC score	0.073952 (rank : 379)
Query Neighborhood Hits	453	Target Neighborhood Hits	276	Shared Neighborhood Hits	24
SwissProt Accessions	Q86TI0, Q96K82, Q9UPP4	Gene names	TBC1D1, KIAA1108
Domain Architecture
Description	TBC1 domain family member 1.

CT012_HUMAN
θ value	0.0113563 (rank : 312)	NC score	0.433207 (rank : 251)
Query Neighborhood Hits	453	Target Neighborhood Hits	205	Shared Neighborhood Hits	167
SwissProt Accessions	Q9NVP4, Q4F7X1, Q5QPD9, Q5QPE0, Q68DN8, Q6ZMX9, Q96NF0, Q9H1E0, Q9H442	Gene names	C20orf12
Domain Architecture
Description	Protein C20orf12.

EPHB4_HUMAN
θ value	0.0113563 (rank : 313)	NC score	0.086739 (rank : 349)
Query Neighborhood Hits	453	Target Neighborhood Hits	1056	Shared Neighborhood Hits	73
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

AN13C_MOUSE
θ value	0.0148317 (rank : 314)	NC score	0.504791 (rank : 230)
Query Neighborhood Hits	453	Target Neighborhood Hits	242	Shared Neighborhood Hits	232
SwissProt Accessions	Q3UX43, Q6P1G4	Gene names	Ankrd13c
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13C.

IKBE_HUMAN
θ value	0.0148317 (rank : 315)	NC score	0.763691 (rank : 129)
Query Neighborhood Hits	453	Target Neighborhood Hits	288	Shared Neighborhood Hits	267
SwissProt Accessions	O00221	Gene names	NFKBIE, IKBE
Domain Architecture
Description	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKBE).

EPHAA_HUMAN
θ value	0.0193708 (rank : 316)	NC score	0.085659 (rank : 356)
Query Neighborhood Hits	453	Target Neighborhood Hits	960	Shared Neighborhood Hits	63
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

TRPC7_HUMAN
θ value	0.0193708 (rank : 317)	NC score	0.115463 (rank : 320)
Query Neighborhood Hits	453	Target Neighborhood Hits	123	Shared Neighborhood Hits	74
SwissProt Accessions	Q9HCX4	Gene names	TRPC7, TRP7
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (TRP7 protein).

TRPC7_MOUSE
θ value	0.0193708 (rank : 318)	NC score	0.115190 (rank : 323)
Query Neighborhood Hits	453	Target Neighborhood Hits	114	Shared Neighborhood Hits	74
SwissProt Accessions	Q9WVC5	Gene names	Trpc7, Trp7, Trrp8
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (mTRP7).

DDEF2_HUMAN
θ value	0.0252991 (rank : 319)	NC score	0.372795 (rank : 262)
Query Neighborhood Hits	453	Target Neighborhood Hits	599	Shared Neighborhood Hits	242
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DGKI_HUMAN
θ value	0.0252991 (rank : 320)	NC score	0.339643 (rank : 269)
Query Neighborhood Hits	453	Target Neighborhood Hits	609	Shared Neighborhood Hits	221
SwissProt Accessions	O75912, Q9NZ49	Gene names	DGKI
Domain Architecture
Description	Diacylglycerol kinase iota (EC 2.7.1.107) (Diglyceride kinase iota) (DGK-iota) (DAG kinase iota).

RSNL2_HUMAN
θ value	0.0330416 (rank : 321)	NC score	0.251980 (rank : 284)
Query Neighborhood Hits	453	Target Neighborhood Hits	136	Shared Neighborhood Hits	113
SwissProt Accessions	Q8N3C7, Q7Z4U3, Q96BR7, Q96MA5, Q9H7C0	Gene names	RSNL2
Domain Architecture	No domain graphic available
Description	Restin-like protein 2.

LIPB2_HUMAN
θ value	0.0431538 (rank : 322)	NC score	0.080387 (rank : 372)
Query Neighborhood Hits	453	Target Neighborhood Hits	599	Shared Neighborhood Hits	40
SwissProt Accessions	Q8ND30, O75337, Q8WW26	Gene names	PPFIBP2
Domain Architecture
Description	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2).

NFH_MOUSE
θ value	0.0431538 (rank : 323)	NC score	0.032320 (rank : 446)
Query Neighborhood Hits	453	Target Neighborhood Hits	2247	Shared Neighborhood Hits	98
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

TRPV5_MOUSE
θ value	0.0431538 (rank : 324)	NC score	0.491434 (rank : 233)
Query Neighborhood Hits	453	Target Neighborhood Hits	278	Shared Neighborhood Hits	246
SwissProt Accessions	P69744	Gene names	Trpv5
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC1) (Calcium transport protein 2) (CaT2).

ANR43_HUMAN
θ value	0.0563607 (rank : 325)	NC score	0.600849 (rank : 196)
Query Neighborhood Hits	453	Target Neighborhood Hits	209	Shared Neighborhood Hits	202
SwissProt Accessions	Q2M3V2, Q8NAE7	Gene names	ANKRD43
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 43.

ASB6_MOUSE
θ value	0.0563607 (rank : 326)	NC score	0.696091 (rank : 166)
Query Neighborhood Hits	453	Target Neighborhood Hits	264	Shared Neighborhood Hits	243
SwissProt Accessions	Q91ZU1, Q8VEC6	Gene names	Asb6
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 6 (ASB-6).

SAM14_HUMAN
θ value	0.0563607 (rank : 327)	NC score	0.083333 (rank : 365)
Query Neighborhood Hits	453	Target Neighborhood Hits	81	Shared Neighborhood Hits	27
SwissProt Accessions	Q8IZD0, Q8N2X0	Gene names	SAMD14
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 14.

ANKZ1_MOUSE
θ value	0.0736092 (rank : 328)	NC score	0.352554 (rank : 266)
Query Neighborhood Hits	453	Target Neighborhood Hits	208	Shared Neighborhood Hits	154
SwissProt Accessions	Q80UU1, Q9CZF5	Gene names	Ankzf1, D1Ertd161e
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1.

EPHA4_MOUSE
θ value	0.0736092 (rank : 329)	NC score	0.081982 (rank : 369)
Query Neighborhood Hits	453	Target Neighborhood Hits	982	Shared Neighborhood Hits	64
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

SAM14_MOUSE
θ value	0.0736092 (rank : 330)	NC score	0.086164 (rank : 355)
Query Neighborhood Hits	453	Target Neighborhood Hits	91	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K070, Q5SWB7, Q8BHE2, Q8C8N5	Gene names	Samd14
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 14.

ANKZ1_HUMAN
θ value	0.0961366 (rank : 331)	NC score	0.341016 (rank : 268)
Query Neighborhood Hits	453	Target Neighborhood Hits	236	Shared Neighborhood Hits	159
SwissProt Accessions	Q9H8Y5, Q9NVZ4	Gene names	ANKZF1, ZNF744
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1 (Zinc finger protein 744).

PRPF3_HUMAN
θ value	0.0961366 (rank : 332)	NC score	0.036709 (rank : 435)
Query Neighborhood Hits	453	Target Neighborhood Hits	65	Shared Neighborhood Hits	8
SwissProt Accessions	O43395, O43446	Gene names	PRPF3, HPRP3, PRP3
Domain Architecture
Description	U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) (U4/U6 snRNP 90 kDa protein) (hPrp3).

PRPF3_MOUSE
θ value	0.0961366 (rank : 333)	NC score	0.035916 (rank : 437)
Query Neighborhood Hits	453	Target Neighborhood Hits	74	Shared Neighborhood Hits	8
SwissProt Accessions	Q922U1, Q3TJH4, Q9D6C6	Gene names	Prpf3
Domain Architecture
Description	U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3).

ASB6_HUMAN
θ value	0.125558 (rank : 334)	NC score	0.700097 (rank : 164)
Query Neighborhood Hits	453	Target Neighborhood Hits	256	Shared Neighborhood Hits	244
SwissProt Accessions	Q9NWX5	Gene names	ASB6
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 6 (ASB-6).

EPHA4_HUMAN
θ value	0.125558 (rank : 335)	NC score	0.081576 (rank : 370)
Query Neighborhood Hits	453	Target Neighborhood Hits	975	Shared Neighborhood Hits	64
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

DGKZ_HUMAN
θ value	0.163984 (rank : 336)	NC score	0.358978 (rank : 264)
Query Neighborhood Hits	453	Target Neighborhood Hits	551	Shared Neighborhood Hits	220
SwissProt Accessions	Q13574, O00542	Gene names	DGKZ, DAGK6
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

PKHA6_MOUSE
θ value	0.163984 (rank : 337)	NC score	0.033871 (rank : 441)
Query Neighborhood Hits	453	Target Neighborhood Hits	591	Shared Neighborhood Hits	36
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

LIPA2_HUMAN
θ value	0.21417 (rank : 338)	NC score	0.050132 (rank : 426)
Query Neighborhood Hits	453	Target Neighborhood Hits	1044	Shared Neighborhood Hits	56
SwissProt Accessions	O75334	Gene names	PPFIA2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

LIPA2_MOUSE
θ value	0.21417 (rank : 339)	NC score	0.047306 (rank : 429)
Query Neighborhood Hits	453	Target Neighborhood Hits	1282	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BSS9, Q8BN73	Gene names	Ppfia2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

AN13B_HUMAN
θ value	0.279714 (rank : 340)	NC score	0.513814 (rank : 228)
Query Neighborhood Hits	453	Target Neighborhood Hits	265	Shared Neighborhood Hits	251
SwissProt Accessions	Q86YJ7, Q8N7S9	Gene names	ANKRD13B
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13B.

AN13B_MOUSE
θ value	0.279714 (rank : 341)	NC score	0.513812 (rank : 229)
Query Neighborhood Hits	453	Target Neighborhood Hits	276	Shared Neighborhood Hits	250
SwissProt Accessions	Q5F259, Q6IR40	Gene names	Ankrd13b
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13B.

ARI1A_HUMAN
θ value	0.279714 (rank : 342)	NC score	0.033111 (rank : 445)
Query Neighborhood Hits	453	Target Neighborhood Hits	787	Shared Neighborhood Hits	46
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

LIPA1_HUMAN
θ value	0.279714 (rank : 343)	NC score	0.044675 (rank : 431)
Query Neighborhood Hits	453	Target Neighborhood Hits	1294	Shared Neighborhood Hits	58
SwissProt Accessions	Q13136, Q13135, Q14567, Q8N4I2	Gene names	PPFIA1, LIP1
Domain Architecture
Description	Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) (LAR-interacting protein 1) (LIP.1).

GIT1_HUMAN
θ value	0.365318 (rank : 344)	NC score	0.455609 (rank : 246)
Query Neighborhood Hits	453	Target Neighborhood Hits	336	Shared Neighborhood Hits	248
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

GIT1_MOUSE
θ value	0.365318 (rank : 345)	NC score	0.457175 (rank : 243)
Query Neighborhood Hits	453	Target Neighborhood Hits	341	Shared Neighborhood Hits	250
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

STK10_HUMAN
θ value	0.47712 (rank : 346)	NC score	0.034148 (rank : 440)
Query Neighborhood Hits	453	Target Neighborhood Hits	1921	Shared Neighborhood Hits	98
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

TRPV3_MOUSE
θ value	0.47712 (rank : 347)	NC score	0.236034 (rank : 286)
Query Neighborhood Hits	453	Target Neighborhood Hits	188	Shared Neighborhood Hits	132
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

SH2D5_MOUSE
θ value	0.62314 (rank : 348)	NC score	0.033631 (rank : 444)
Query Neighborhood Hits	453	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	Q8JZW5	Gene names	Sh2d5
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 5.

STK10_MOUSE
θ value	0.62314 (rank : 349)	NC score	0.035142 (rank : 438)
Query Neighborhood Hits	453	Target Neighborhood Hits	2132	Shared Neighborhood Hits	100
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

YSK4_HUMAN
θ value	0.62314 (rank : 350)	NC score	0.031003 (rank : 448)
Query Neighborhood Hits	453	Target Neighborhood Hits	921	Shared Neighborhood Hits	53
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

CENG2_HUMAN
θ value	0.813845 (rank : 351)	NC score	0.320926 (rank : 271)
Query Neighborhood Hits	453	Target Neighborhood Hits	471	Shared Neighborhood Hits	255
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

CENG2_MOUSE
θ value	0.813845 (rank : 352)	NC score	0.318245 (rank : 274)
Query Neighborhood Hits	453	Target Neighborhood Hits	463	Shared Neighborhood Hits	252
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

DDFL1_HUMAN
θ value	0.813845 (rank : 353)	NC score	0.355311 (rank : 265)
Query Neighborhood Hits	453	Target Neighborhood Hits	353	Shared Neighborhood Hits	233
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

EPHB6_MOUSE
θ value	0.813845 (rank : 354)	NC score	0.086512 (rank : 353)
Query Neighborhood Hits	453	Target Neighborhood Hits	906	Shared Neighborhood Hits	60
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

HIPK3_MOUSE
θ value	0.813845 (rank : 355)	NC score	0.014259 (rank : 467)
Query Neighborhood Hits	453	Target Neighborhood Hits	857	Shared Neighborhood Hits	44
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

LIPA4_HUMAN
θ value	0.813845 (rank : 356)	NC score	0.053805 (rank : 404)
Query Neighborhood Hits	453	Target Neighborhood Hits	56	Shared Neighborhood Hits	20
SwissProt Accessions	O75335, O94971	Gene names	PPFIA4, KIAA0897
Domain Architecture
Description	Liprin-alpha-4 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4) (PTPRF-interacting protein alpha-4).

TLE2_HUMAN
θ value	0.813845 (rank : 357)	NC score	0.001951 (rank : 495)
Query Neighborhood Hits	453	Target Neighborhood Hits	321	Shared Neighborhood Hits	8
SwissProt Accessions	Q04725, Q8WVY0, Q9Y6S0	Gene names	TLE2
Domain Architecture
Description	Transducin-like enhancer protein 2 (ESG2).

URFB1_HUMAN
θ value	0.813845 (rank : 358)	NC score	0.024822 (rank : 455)
Query Neighborhood Hits	453	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	Q6BDS2, Q9NXE0	Gene names	UHRF1BP1, C6orf107
Domain Architecture	No domain graphic available
Description	UHRF1-binding protein 1 (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) (ICBP90-binding protein 1).

WNK2_HUMAN
θ value	0.813845 (rank : 359)	NC score	0.039944 (rank : 433)
Query Neighborhood Hits	453	Target Neighborhood Hits	1407	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

ABTB1_MOUSE
θ value	1.06291 (rank : 360)	NC score	0.289484 (rank : 280)
Query Neighborhood Hits	453	Target Neighborhood Hits	349	Shared Neighborhood Hits	177
SwissProt Accessions	Q99LJ2, Q8C2K7, Q91XU4	Gene names	Abtb1, Bpoz
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 1.

CENG3_HUMAN
θ value	1.06291 (rank : 361)	NC score	0.290793 (rank : 278)
Query Neighborhood Hits	453	Target Neighborhood Hits	455	Shared Neighborhood Hits	228
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_MOUSE
θ value	1.06291 (rank : 362)	NC score	0.291176 (rank : 277)
Query Neighborhood Hits	453	Target Neighborhood Hits	467	Shared Neighborhood Hits	229
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

DGKD_HUMAN
θ value	1.06291 (rank : 363)	NC score	0.068949 (rank : 385)
Query Neighborhood Hits	453	Target Neighborhood Hits	231	Shared Neighborhood Hits	60
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

GIT2_MOUSE
θ value	1.06291 (rank : 364)	NC score	0.472405 (rank : 236)
Query Neighborhood Hits	453	Target Neighborhood Hits	323	Shared Neighborhood Hits	253
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

HIPK3_HUMAN
θ value	1.06291 (rank : 365)	NC score	0.014270 (rank : 466)
Query Neighborhood Hits	453	Target Neighborhood Hits	867	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

LIPA3_HUMAN
θ value	1.06291 (rank : 366)	NC score	0.045969 (rank : 430)
Query Neighborhood Hits	453	Target Neighborhood Hits	828	Shared Neighborhood Hits	45
SwissProt Accessions	O75145, Q9H8B5, Q9UEW4	Gene names	PPFIA3, KIAA0654
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

LIPA3_MOUSE
θ value	1.06291 (rank : 367)	NC score	0.052697 (rank : 405)
Query Neighborhood Hits	453	Target Neighborhood Hits	636	Shared Neighborhood Hits	41
SwissProt Accessions	P60469	Gene names	Ppfia3
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

RP1L1_HUMAN
θ value	1.06291 (rank : 368)	NC score	0.033639 (rank : 443)
Query Neighborhood Hits	453	Target Neighborhood Hits	1072	Shared Neighborhood Hits	56
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

TRPV1_MOUSE
θ value	1.06291 (rank : 369)	NC score	0.230568 (rank : 289)
Query Neighborhood Hits	453	Target Neighborhood Hits	189	Shared Neighborhood Hits	155
SwissProt Accessions	Q704Y3, Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0	Gene names	Trpv1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).

ASB14_HUMAN
θ value	1.38821 (rank : 370)	NC score	0.535466 (rank : 220)
Query Neighborhood Hits	453	Target Neighborhood Hits	187	Shared Neighborhood Hits	175
SwissProt Accessions	Q8WXK2	Gene names	ASB14
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 14 (ASB-14).

CDN2B_HUMAN
θ value	1.38821 (rank : 371)	NC score	0.593957 (rank : 199)
Query Neighborhood Hits	453	Target Neighborhood Hits	196	Shared Neighborhood Hits	195
SwissProt Accessions	P42772, Q6FI09	Gene names	CDKN2B, MTS2
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b) (p15INK4B) (Multiple tumor suppressor 2) (MTS2).

CENG1_MOUSE
θ value	1.38821 (rank : 372)	NC score	0.320635 (rank : 272)
Query Neighborhood Hits	453	Target Neighborhood Hits	531	Shared Neighborhood Hits	246
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

GRIN1_HUMAN
θ value	1.38821 (rank : 373)	NC score	0.036601 (rank : 436)
Query Neighborhood Hits	453	Target Neighborhood Hits	681	Shared Neighborhood Hits	49
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

NPBL_MOUSE
θ value	1.38821 (rank : 374)	NC score	0.015451 (rank : 464)
Query Neighborhood Hits	453	Target Neighborhood Hits	1041	Shared Neighborhood Hits	46
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

SHAN2_HUMAN
θ value	1.38821 (rank : 375)	NC score	0.082130 (rank : 367)
Query Neighborhood Hits	453	Target Neighborhood Hits	346	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

SHAN2_MOUSE
θ value	1.38821 (rank : 376)	NC score	0.082087 (rank : 368)
Query Neighborhood Hits	453	Target Neighborhood Hits	446	Shared Neighborhood Hits	65
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

DDEF2_MOUSE
θ value	1.81305 (rank : 377)	NC score	0.366755 (rank : 263)
Query Neighborhood Hits	453	Target Neighborhood Hits	625	Shared Neighborhood Hits	241
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DGKH_HUMAN
θ value	1.81305 (rank : 378)	NC score	0.056776 (rank : 394)
Query Neighborhood Hits	453	Target Neighborhood Hits	255	Shared Neighborhood Hits	57
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

EPHB6_HUMAN
θ value	1.81305 (rank : 379)	NC score	0.086293 (rank : 354)
Query Neighborhood Hits	453	Target Neighborhood Hits	912	Shared Neighborhood Hits	62
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

GIT2_HUMAN
θ value	1.81305 (rank : 380)	NC score	0.436017 (rank : 249)
Query Neighborhood Hits	453	Target Neighborhood Hits	381	Shared Neighborhood Hits	247
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

HORN_MOUSE
θ value	1.81305 (rank : 381)	NC score	0.016327 (rank : 463)
Query Neighborhood Hits	453	Target Neighborhood Hits	218	Shared Neighborhood Hits	10
SwissProt Accessions	Q8VHD8	Gene names	Hrnr
Domain Architecture
Description	Hornerin.

SARM1_MOUSE
θ value	1.81305 (rank : 382)	NC score	0.076623 (rank : 375)
Query Neighborhood Hits	453	Target Neighborhood Hits	54	Shared Neighborhood Hits	27
SwissProt Accessions	Q6PDS3, Q5SYG5, Q5SYG6, Q6A054, Q6SZW0, Q8BRI9	Gene names	Sarm1, Kiaa0524
Domain Architecture	No domain graphic available
Description	Sterile alpha and TIR motif-containing protein 1 (Tir-1 homolog).

SYP2L_HUMAN
θ value	1.81305 (rank : 383)	NC score	0.016759 (rank : 462)
Query Neighborhood Hits	453	Target Neighborhood Hits	400	Shared Neighborhood Hits	29
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

ABTB1_HUMAN
θ value	2.36792 (rank : 384)	NC score	0.247849 (rank : 285)
Query Neighborhood Hits	453	Target Neighborhood Hits	325	Shared Neighborhood Hits	162
SwissProt Accessions	Q969K4, Q6ZNU9, Q71MF1, Q96S62, Q96S63	Gene names	ABTB1, BPOZ
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 1 (Elongation factor 1A-binding protein).

CENG1_HUMAN
θ value	2.36792 (rank : 385)	NC score	0.318560 (rank : 273)
Query Neighborhood Hits	453	Target Neighborhood Hits	544	Shared Neighborhood Hits	247
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

LAMA5_HUMAN
θ value	2.36792 (rank : 386)	NC score	0.034769 (rank : 439)
Query Neighborhood Hits	453	Target Neighborhood Hits	976	Shared Neighborhood Hits	47
SwissProt Accessions	O15230, Q8WZA7, Q9H1P1	Gene names	LAMA5, KIAA0533, KIAA1907
Domain Architecture
Description	Laminin alpha-5 chain precursor.

MELPH_MOUSE
θ value	2.36792 (rank : 387)	NC score	0.011021 (rank : 474)
Query Neighborhood Hits	453	Target Neighborhood Hits	112	Shared Neighborhood Hits	10
SwissProt Accessions	Q91V27, Q99N53	Gene names	Mlph, Ln, Slac2a
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Leaden protein) (Synaptotagmin-like protein 2a) (Slac2-a) (Slp homolog lacking C2 domains a).

SIP1_HUMAN
θ value	2.36792 (rank : 388)	NC score	-0.012912 (rank : 501)
Query Neighborhood Hits	453	Target Neighborhood Hits	832	Shared Neighborhood Hits	12
SwissProt Accessions	O60315, Q9UED1	Gene names	ZFHX1B, KIAA0569, SIP1, ZFX1B
Domain Architecture
Description	Zinc finger homeobox protein 1b (Smad-interacting protein 1) (SMADIP1).

TENS4_MOUSE
θ value	2.36792 (rank : 389)	NC score	0.020408 (rank : 459)
Query Neighborhood Hits	453	Target Neighborhood Hits	225	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

COG8_HUMAN
θ value	3.0926 (rank : 390)	NC score	0.026995 (rank : 452)
Query Neighborhood Hits	453	Target Neighborhood Hits	21	Shared Neighborhood Hits	7
SwissProt Accessions	Q96MW5, Q8WVV6, Q9H6F8	Gene names	COG8
Domain Architecture
Description	Conserved oligomeric Golgi complex component 8.

HORN_HUMAN
θ value	3.0926 (rank : 391)	NC score	0.010933 (rank : 475)
Query Neighborhood Hits	453	Target Neighborhood Hits	206	Shared Neighborhood Hits	13
SwissProt Accessions	Q86YZ3	Gene names	HRNR, S100A18
Domain Architecture	No domain graphic available
Description	Hornerin.

NGN2_HUMAN
θ value	3.0926 (rank : 392)	NC score	0.002450 (rank : 494)
Query Neighborhood Hits	453	Target Neighborhood Hits	92	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H2A3, Q8N416	Gene names	NEUROG2, NGN2
Domain Architecture	No domain graphic available
Description	Neurogenin 2.

SARM1_HUMAN
θ value	3.0926 (rank : 393)	NC score	0.064310 (rank : 387)
Query Neighborhood Hits	453	Target Neighborhood Hits	58	Shared Neighborhood Hits	21
SwissProt Accessions	Q6SZW1, O60277, Q7LGG3, Q9NXY5	Gene names	SARM1, KIAA0524, SARM
Domain Architecture	No domain graphic available
Description	Sterile alpha and TIR motif-containing protein 1 (Sterile alpha and Armadillo repeat protein) (Tir-1 homolog).

THNSL_HUMAN
θ value	3.0926 (rank : 394)	NC score	0.008815 (rank : 479)
Query Neighborhood Hits	453	Target Neighborhood Hits	47	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IYQ7, Q5VV21	Gene names	THNSL1
Domain Architecture	No domain graphic available
Description	Threonine synthase-like 1.

ZFP38_MOUSE
θ value	3.0926 (rank : 395)	NC score	-0.013972 (rank : 504)
Query Neighborhood Hits	453	Target Neighborhood Hits	768	Shared Neighborhood Hits	11
SwissProt Accessions	Q07231	Gene names	Znf38, Zfp-38, Zfp38, Zipro1
Domain Architecture
Description	Zinc finger protein 38 (Zfp-38) (CtFIN51) (Transcription factor RU49).

ADDA_MOUSE
θ value	4.03905 (rank : 396)	NC score	0.009319 (rank : 478)
Query Neighborhood Hits	453	Target Neighborhood Hits	198	Shared Neighborhood Hits	16
SwissProt Accessions	Q9QYC0, Q9JLE3	Gene names	Add1
Domain Architecture
Description	Alpha-adducin (Erythrocyte adducin subunit alpha).

AKAP6_HUMAN
θ value	4.03905 (rank : 397)	NC score	0.013463 (rank : 468)
Query Neighborhood Hits	453	Target Neighborhood Hits	263	Shared Neighborhood Hits	10
SwissProt Accessions	Q13023, O15028	Gene names	AKAP6, AKAP100, KIAA0311
Domain Architecture
Description	A-kinase anchor protein 6 (Protein kinase A-anchoring protein 6) (PRKA6) (A-kinase anchor protein 100 kDa) (AKAP 100) (mAKAP).

CABIN_HUMAN
θ value	4.03905 (rank : 398)	NC score	0.031113 (rank : 447)
Query Neighborhood Hits	453	Target Neighborhood Hits	490	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

CBX4_MOUSE
θ value	4.03905 (rank : 399)	NC score	0.009914 (rank : 476)
Query Neighborhood Hits	453	Target Neighborhood Hits	64	Shared Neighborhood Hits	6
SwissProt Accessions	O55187	Gene names	Cbx4, Pc2
Domain Architecture
Description	Chromobox protein homolog 4 (Polycomb 2 homolog) (Pc2) (mPc2).

CEND1_MOUSE
θ value	4.03905 (rank : 400)	NC score	0.049770 (rank : 428)
Query Neighborhood Hits	453	Target Neighborhood Hits	260	Shared Neighborhood Hits	57
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

DGKZ_MOUSE
θ value	4.03905 (rank : 401)	NC score	0.337924 (rank : 270)
Query Neighborhood Hits	453	Target Neighborhood Hits	542	Shared Neighborhood Hits	205
SwissProt Accessions	Q80UP3	Gene names	Dgkz
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

FANCM_HUMAN
θ value	4.03905 (rank : 402)	NC score	0.006787 (rank : 487)
Query Neighborhood Hits	453	Target Neighborhood Hits	210	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

GLIS1_HUMAN
θ value	4.03905 (rank : 403)	NC score	-0.012313 (rank : 500)
Query Neighborhood Hits	453	Target Neighborhood Hits	748	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NBF1, Q8N9V9	Gene names	GLIS1
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS1 (GLI-similar 1).

LAP2_HUMAN
θ value	4.03905 (rank : 404)	NC score	-0.001709 (rank : 497)
Query Neighborhood Hits	453	Target Neighborhood Hits	499	Shared Neighborhood Hits	14
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

PRRT3_HUMAN
θ value	4.03905 (rank : 405)	NC score	0.037620 (rank : 434)
Query Neighborhood Hits	453	Target Neighborhood Hits	998	Shared Neighborhood Hits	47
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

TIM_MOUSE
θ value	4.03905 (rank : 406)	NC score	0.007583 (rank : 484)
Query Neighborhood Hits	453	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R1X4, Q63ZX9, Q6P204, Q6PDL4, Q7TPV8, Q8R0Q2, Q9R268, Q9Z0E7	Gene names	Timeless, Tim1, Timeless1
Domain Architecture	No domain graphic available
Description	Timeless homolog (mTim).

ZN366_HUMAN
θ value	4.03905 (rank : 407)	NC score	-0.013890 (rank : 502)
Query Neighborhood Hits	453	Target Neighborhood Hits	732	Shared Neighborhood Hits	8
SwissProt Accessions	Q8N895, Q7RTV4	Gene names	ZNF366
Domain Architecture	No domain graphic available
Description	Zinc finger protein 366.

3BP1_MOUSE
θ value	5.27518 (rank : 408)	NC score	0.009852 (rank : 477)
Query Neighborhood Hits	453	Target Neighborhood Hits	238	Shared Neighborhood Hits	20
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

BSN_HUMAN
θ value	5.27518 (rank : 409)	NC score	0.033746 (rank : 442)
Query Neighborhood Hits	453	Target Neighborhood Hits	1537	Shared Neighborhood Hits	80
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CATF_HUMAN
θ value	5.27518 (rank : 410)	NC score	0.003343 (rank : 493)
Query Neighborhood Hits	453	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UBX1, O95240, Q9NSU4, Q9UKQ5	Gene names	CTSF
Domain Architecture
Description	Cathepsin F precursor (EC 3.4.22.41) (CATSF).

CEND1_HUMAN
θ value	5.27518 (rank : 411)	NC score	0.055582 (rank : 395)
Query Neighborhood Hits	453	Target Neighborhood Hits	284	Shared Neighborhood Hits	61
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CNTP1_MOUSE
θ value	5.27518 (rank : 412)	NC score	0.012354 (rank : 471)
Query Neighborhood Hits	453	Target Neighborhood Hits	183	Shared Neighborhood Hits	16
SwissProt Accessions	O54991	Gene names	Cntnap1, Nrxn4
Domain Architecture
Description	Contactin-associated protein 1 precursor (Caspr) (Caspr1) (Neurexin 4) (Neurexin IV) (Paranodin) (NCP1) (MHDNIV).

CSPG2_HUMAN
θ value	5.27518 (rank : 413)	NC score	0.027116 (rank : 451)
Query Neighborhood Hits	453	Target Neighborhood Hits	681	Shared Neighborhood Hits	23
SwissProt Accessions	P13611, P20754, Q13010, Q13189, Q15123, Q9UCL9, Q9UNW5	Gene names	CSPG2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M) (Glial hyaluronate-binding protein) (GHAP).

IKBL_HUMAN
θ value	5.27518 (rank : 414)	NC score	0.317301 (rank : 275)
Query Neighborhood Hits	453	Target Neighborhood Hits	168	Shared Neighborhood Hits	139
SwissProt Accessions	Q9UBC1, Q14625, Q9UBX4	Gene names	NFKBIL1, IKBL
Domain Architecture
Description	NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like) (I- kappa-B-like) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1).

IKBL_MOUSE
θ value	5.27518 (rank : 415)	NC score	0.309954 (rank : 276)
Query Neighborhood Hits	453	Target Neighborhood Hits	196	Shared Neighborhood Hits	139
SwissProt Accessions	O88995, Q91X16, Q9R1Y3	Gene names	Nfkbil1, Ikbl
Domain Architecture
Description	NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like) (I- kappa-B-like) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1).

LRP5_HUMAN
θ value	5.27518 (rank : 416)	NC score	0.000744 (rank : 496)
Query Neighborhood Hits	453	Target Neighborhood Hits	224	Shared Neighborhood Hits	8
SwissProt Accessions	O75197, Q96TD6, Q9UP66	Gene names	LRP5, LRP7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor.

RSNL2_MOUSE
θ value	5.27518 (rank : 417)	NC score	0.202901 (rank : 292)
Query Neighborhood Hits	453	Target Neighborhood Hits	129	Shared Neighborhood Hits	95
SwissProt Accessions	Q8CI96, Q8BW09, Q921Q4, Q9D2S6	Gene names	Rsnl2
Domain Architecture	No domain graphic available
Description	Restin-like protein 2.

SRBS1_MOUSE
θ value	5.27518 (rank : 418)	NC score	0.020521 (rank : 458)
Query Neighborhood Hits	453	Target Neighborhood Hits	409	Shared Neighborhood Hits	36
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

TRPV3_HUMAN
θ value	5.27518 (rank : 419)	NC score	0.231211 (rank : 288)
Query Neighborhood Hits	453	Target Neighborhood Hits	198	Shared Neighborhood Hits	142
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

BAT4_HUMAN
θ value	6.88961 (rank : 420)	NC score	0.236026 (rank : 287)
Query Neighborhood Hits	453	Target Neighborhood Hits	157	Shared Neighborhood Hits	110
SwissProt Accessions	O95872	Gene names	BAT4, G5
Domain Architecture
Description	Protein BAT4 (HLA-B-associated transcript 4) (G5 protein).

BAT4_MOUSE
θ value	6.88961 (rank : 421)	NC score	0.266116 (rank : 282)
Query Neighborhood Hits	453	Target Neighborhood Hits	171	Shared Neighborhood Hits	121
SwissProt Accessions	Q61858, Q9R065	Gene names	Bat4, Bat-4, G5
Domain Architecture
Description	Protein BAT4 (HLA-B-associated transcript 4) (G5 protein).

CBP_MOUSE
θ value	6.88961 (rank : 422)	NC score	0.028191 (rank : 449)
Query Neighborhood Hits	453	Target Neighborhood Hits	1051	Shared Neighborhood Hits	58
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

GP73_HUMAN
θ value	6.88961 (rank : 423)	NC score	0.012781 (rank : 470)
Query Neighborhood Hits	453	Target Neighborhood Hits	309	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NBJ4, Q6IAF4, Q9NRB9	Gene names	GOLPH2
Domain Architecture	No domain graphic available
Description	Golgi phosphoprotein 2 (Golgi membrane protein GP73).

KKCC1_HUMAN
θ value	6.88961 (rank : 424)	NC score	0.021455 (rank : 457)
Query Neighborhood Hits	453	Target Neighborhood Hits	858	Shared Neighborhood Hits	46
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

MDC1_HUMAN
θ value	6.88961 (rank : 425)	NC score	0.040593 (rank : 432)
Query Neighborhood Hits	453	Target Neighborhood Hits	1446	Shared Neighborhood Hits	68
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

RECQ5_HUMAN
θ value	6.88961 (rank : 426)	NC score	0.004589 (rank : 489)
Query Neighborhood Hits	453	Target Neighborhood Hits	390	Shared Neighborhood Hits	19
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

RGNEF_MOUSE
θ value	6.88961 (rank : 427)	NC score	0.004476 (rank : 490)
Query Neighborhood Hits	453	Target Neighborhood Hits	641	Shared Neighborhood Hits	32
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

SAMD4_HUMAN
θ value	6.88961 (rank : 428)	NC score	0.012169 (rank : 472)
Query Neighborhood Hits	453	Target Neighborhood Hits	21	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UPU9	Gene names	SAMD4, KIAA1053
Domain Architecture
Description	Sterile alpha motif domain-containing protein 4.

SAMD4_MOUSE
θ value	6.88961 (rank : 429)	NC score	0.015360 (rank : 465)
Query Neighborhood Hits	453	Target Neighborhood Hits	25	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CBY1	Gene names	Samd4
Domain Architecture
Description	Sterile alpha motif domain-containing protein 4.

SERC_MOUSE
θ value	6.88961 (rank : 430)	NC score	0.006651 (rank : 488)
Query Neighborhood Hits	453	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	Q99K85	Gene names	Psat1, Psa, Psat
Domain Architecture
Description	Phosphoserine aminotransferase (EC 2.6.1.52) (PSAT) (Endometrial progesterone-induced protein) (EPIP).

STON2_HUMAN
θ value	6.88961 (rank : 431)	NC score	0.003937 (rank : 491)
Query Neighborhood Hits	453	Target Neighborhood Hits	115	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WXE9, Q6NT47, Q96RI7, Q96RU6	Gene names	STON2, STN2, STNB
Domain Architecture
Description	Stonin-2 (Stoned B).

TCAL4_HUMAN
θ value	6.88961 (rank : 432)	NC score	0.007381 (rank : 486)
Query Neighborhood Hits	453	Target Neighborhood Hits	76	Shared Neighborhood Hits	7
SwissProt Accessions	Q96EI5, Q8WY12, Q9H2H1, Q9H775	Gene names	TCEAL4
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 4 (TCEA-like protein 4) (Transcription elongation factor S-II protein-like 4).

UBP42_HUMAN
θ value	6.88961 (rank : 433)	NC score	0.008307 (rank : 482)
Query Neighborhood Hits	453	Target Neighborhood Hits	445	Shared Neighborhood Hits	28
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

WBP11_HUMAN
θ value	6.88961 (rank : 434)	NC score	0.027509 (rank : 450)
Query Neighborhood Hits	453	Target Neighborhood Hits	354	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

ZO1_HUMAN
θ value	6.88961 (rank : 435)	NC score	0.008303 (rank : 483)
Query Neighborhood Hits	453	Target Neighborhood Hits	474	Shared Neighborhood Hits	22
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ARI1B_HUMAN
θ value	8.99809 (rank : 436)	NC score	0.019050 (rank : 460)
Query Neighborhood Hits	453	Target Neighborhood Hits	567	Shared Neighborhood Hits	38
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

CD008_HUMAN
θ value	8.99809 (rank : 437)	NC score	0.008687 (rank : 480)
Query Neighborhood Hits	453	Target Neighborhood Hits	330	Shared Neighborhood Hits	20
SwissProt Accessions	P78312, O43607, P78311, P78313, Q9UEG8	Gene names	C4orf8
Domain Architecture	No domain graphic available
Description	Protein C4orf8 (Protein IT14).

CEND3_MOUSE
θ value	8.99809 (rank : 438)	NC score	0.057283 (rank : 392)
Query Neighborhood Hits	453	Target Neighborhood Hits	228	Shared Neighborhood Hits	62
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CMTA2_HUMAN
θ value	8.99809 (rank : 439)	NC score	0.151438 (rank : 303)
Query Neighborhood Hits	453	Target Neighborhood Hits	199	Shared Neighborhood Hits	90
SwissProt Accessions	O94983, Q7Z6M8, Q8N3V0, Q8NDG4, Q96G17	Gene names	CAMTA2, KIAA0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

CNTP1_HUMAN
θ value	8.99809 (rank : 440)	NC score	0.011544 (rank : 473)
Query Neighborhood Hits	453	Target Neighborhood Hits	196	Shared Neighborhood Hits	15
SwissProt Accessions	P78357	Gene names	CNTNAP1, CASPR, NRXN4
Domain Architecture
Description	Contactin-associated protein 1 precursor (Caspr) (Caspr1) (Neurexin 4) (Neurexin IV) (p190).

COG8_MOUSE
θ value	8.99809 (rank : 441)	NC score	0.017313 (rank : 461)
Query Neighborhood Hits	453	Target Neighborhood Hits	147	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JJA2	Gene names	Cog8
Domain Architecture
Description	Conserved oligomeric Golgi complex component 8.

DNL1_HUMAN
θ value	8.99809 (rank : 442)	NC score	0.008639 (rank : 481)
Query Neighborhood Hits	453	Target Neighborhood Hits	216	Shared Neighborhood Hits	13
SwissProt Accessions	P18858	Gene names	LIG1
Domain Architecture
Description	DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1).

MDN1_HUMAN
θ value	8.99809 (rank : 443)	NC score	0.022148 (rank : 456)
Query Neighborhood Hits	453	Target Neighborhood Hits	662	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

MLL2_HUMAN
θ value	8.99809 (rank : 444)	NC score	0.026625 (rank : 453)
Query Neighborhood Hits	453	Target Neighborhood Hits	1788	Shared Neighborhood Hits	69
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

NCOA5_HUMAN
θ value	8.99809 (rank : 445)	NC score	0.003752 (rank : 492)
Query Neighborhood Hits	453	Target Neighborhood Hits	99	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HCD5, Q6HA99, Q9H1F2, Q9H2T2, Q9H4Y9	Gene names	NCOA5, KIAA1637
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA).

NHS_HUMAN
θ value	8.99809 (rank : 446)	NC score	0.012845 (rank : 469)
Query Neighborhood Hits	453	Target Neighborhood Hits	198	Shared Neighborhood Hits	14
SwissProt Accessions	Q6T4R5, Q5J7Q0, Q5J7Q1, Q68DR5	Gene names	NHS
Domain Architecture	No domain graphic available
Description	Nance-Horan syndrome protein (Congenital cataracts and dental anomalies protein).

NKX24_HUMAN
θ value	8.99809 (rank : 447)	NC score	-0.005918 (rank : 498)
Query Neighborhood Hits	453	Target Neighborhood Hits	366	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H2Z4	Gene names	NKX2-4, NKX2D
Domain Architecture
Description	Homeobox protein Nkx-2.4 (Homeobox protein NKX2.4) (Homeobox protein NK-2 homolog D).

NKX24_MOUSE
θ value	8.99809 (rank : 448)	NC score	-0.006851 (rank : 499)
Query Neighborhood Hits	453	Target Neighborhood Hits	356	Shared Neighborhood Hits	6
SwissProt Accessions	Q9EQM3, Q9EQM4	Gene names	Nkx2-4, Nkx2d
Domain Architecture
Description	Homeobox protein Nkx-2.4 (Homeobox protein NKX2.4) (Homeobox protein NK-2 homolog D).

RERE_HUMAN
θ value	8.99809 (rank : 449)	NC score	0.026372 (rank : 454)
Query Neighborhood Hits	453	Target Neighborhood Hits	779	Shared Neighborhood Hits	61
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

STIM2_HUMAN
θ value	8.99809 (rank : 450)	NC score	0.007474 (rank : 485)
Query Neighborhood Hits	453	Target Neighborhood Hits	420	Shared Neighborhood Hits	18
SwissProt Accessions	Q9P246, Q96BF1, Q9BQH2, Q9H8R1	Gene names	STIM2, KIAA1482
Domain Architecture
Description	Stromal interaction molecule 2 precursor.

TRPC4_HUMAN
θ value	8.99809 (rank : 451)	NC score	0.083908 (rank : 364)
Query Neighborhood Hits	453	Target Neighborhood Hits	140	Shared Neighborhood Hits	75
SwissProt Accessions	Q9UBN4, Q15721, Q9UIB0, Q9UIB1, Q9UIB2	Gene names	TRPC4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (trp-related protein 4) (hTrp-4) (hTrp4).

TRPC4_MOUSE
θ value	8.99809 (rank : 452)	NC score	0.083944 (rank : 363)
Query Neighborhood Hits	453	Target Neighborhood Hits	141	Shared Neighborhood Hits	75
SwissProt Accessions	Q9QUQ5, Q62350, Q9QUQ9, Q9QZC0	Gene names	Trpc4, Trrp4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (Receptor- activated cation channel TRP4) (Capacitative calcium entry channel Trp4).

ZN692_MOUSE
θ value	8.99809 (rank : 453)	NC score	-0.013901 (rank : 503)
Query Neighborhood Hits	453	Target Neighborhood Hits	751	Shared Neighborhood Hits	12
SwissProt Accessions	Q3U381	Gene names	Znf692, Zfp692
Domain Architecture	No domain graphic available
Description	Zinc finger protein 692.

ANKF1_HUMAN
θ value	θ > 10 (rank : 454)	NC score	0.127326 (rank : 315)
Query Neighborhood Hits	453	Target Neighborhood Hits	126	Shared Neighborhood Hits	74
SwissProt Accessions	Q8N957	Gene names	ANKFN1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and fibronectin type-III domain-containing protein 1.

ANKR9_HUMAN
θ value	θ > 10 (rank : 455)	NC score	0.209971 (rank : 291)
Query Neighborhood Hits	453	Target Neighborhood Hits	99	Shared Neighborhood Hits	95
SwissProt Accessions	Q96BM1	Gene names	ANKRD9
Domain Architecture
Description	Ankyrin repeat domain-containing protein 9.

ANKR9_MOUSE
θ value	θ > 10 (rank : 456)	NC score	0.257650 (rank : 283)
Query Neighborhood Hits	453	Target Neighborhood Hits	120	Shared Neighborhood Hits	114
SwissProt Accessions	Q8BH83, Q3TA09, Q8BHR3	Gene names	Ankrd9
Domain Architecture
Description	Ankyrin repeat domain-containing protein 9.

CEND3_HUMAN
θ value	θ > 10 (rank : 457)	NC score	0.059193 (rank : 390)
Query Neighborhood Hits	453	Target Neighborhood Hits	275	Shared Neighborhood Hits	66
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CLR59_HUMAN
θ value	θ > 10 (rank : 458)	NC score	0.287980 (rank : 281)
Query Neighborhood Hits	453	Target Neighborhood Hits	163	Shared Neighborhood Hits	138
SwissProt Accessions	Q96DZ5, Q8WWL1, Q96C99, Q9UFT7	Gene names	CLIPR59
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 170-related 59 kDa protein (CLIPR-59) (CLIP-170-related 59 kDa protein).

CMTA1_HUMAN
θ value	θ > 10 (rank : 459)	NC score	0.184472 (rank : 296)
Query Neighborhood Hits	453	Target Neighborhood Hits	217	Shared Neighborhood Hits	104
SwissProt Accessions	Q9Y6Y1, Q5VUE1	Gene names	CAMTA1, KIAA0833
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 1.

CMTA2_MOUSE
θ value	θ > 10 (rank : 460)	NC score	0.135560 (rank : 312)
Query Neighborhood Hits	453	Target Neighborhood Hits	216	Shared Neighborhood Hits	79
SwissProt Accessions	Q80Y50, Q3TFK0, Q5SX68, Q80TP1, Q8R0D9, Q8R2N5	Gene names	Camta2, Kiaa0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

CU081_HUMAN
θ value	θ > 10 (rank : 461)	NC score	0.076774 (rank : 373)
Query Neighborhood Hits	453	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NFU9	Gene names	C21orf81
Domain Architecture	No domain graphic available
Description	Protein C21orf81.

EPHA3_HUMAN
θ value	θ > 10 (rank : 462)	NC score	0.072924 (rank : 381)
Query Neighborhood Hits	453	Target Neighborhood Hits	1005	Shared Neighborhood Hits	55
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA3_MOUSE
θ value	θ > 10 (rank : 463)	NC score	0.072886 (rank : 382)
Query Neighborhood Hits	453	Target Neighborhood Hits	1009	Shared Neighborhood Hits	55
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

ERBB4_HUMAN
θ value	θ > 10 (rank : 464)	NC score	0.051060 (rank : 417)
Query Neighborhood Hits	453	Target Neighborhood Hits	910	Shared Neighborhood Hits	52
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

FADD_MOUSE
θ value	θ > 10 (rank : 465)	NC score	0.051519 (rank : 414)
Query Neighborhood Hits	453	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	Q61160, Q3TC37, Q61082	Gene names	Fadd, Mort1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

FAK2_HUMAN
θ value	θ > 10 (rank : 466)	NC score	0.050112 (rank : 427)
Query Neighborhood Hits	453	Target Neighborhood Hits	847	Shared Neighborhood Hits	47
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FER_HUMAN
θ value	θ > 10 (rank : 467)	NC score	0.053950 (rank : 402)
Query Neighborhood Hits	453	Target Neighborhood Hits	1278	Shared Neighborhood Hits	67
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FES_MOUSE
θ value	θ > 10 (rank : 468)	NC score	0.050527 (rank : 424)
Query Neighborhood Hits	453	Target Neighborhood Hits	980	Shared Neighborhood Hits	61
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGR_HUMAN
θ value	θ > 10 (rank : 469)	NC score	0.051661 (rank : 411)
Query Neighborhood Hits	453	Target Neighborhood Hits	1067	Shared Neighborhood Hits	67
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FGR_MOUSE
θ value	θ > 10 (rank : 470)	NC score	0.052678 (rank : 406)
Query Neighborhood Hits	453	Target Neighborhood Hits	1069	Shared Neighborhood Hits	66
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FRK_HUMAN
θ value	θ > 10 (rank : 471)	NC score	0.051281 (rank : 415)
Query Neighborhood Hits	453	Target Neighborhood Hits	1058	Shared Neighborhood Hits	64
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

FYN_HUMAN
θ value	θ > 10 (rank : 472)	NC score	0.051637 (rank : 412)
Query Neighborhood Hits	453	Target Neighborhood Hits	1078	Shared Neighborhood Hits	68
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	θ > 10 (rank : 473)	NC score	0.052066 (rank : 408)
Query Neighborhood Hits	453	Target Neighborhood Hits	1073	Shared Neighborhood Hits	66
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

GUC2G_MOUSE
θ value	θ > 10 (rank : 474)	NC score	0.051921 (rank : 410)
Query Neighborhood Hits	453	Target Neighborhood Hits	644	Shared Neighborhood Hits	39
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

IRAK3_HUMAN
θ value	θ > 10 (rank : 475)	NC score	0.055518 (rank : 396)
Query Neighborhood Hits	453	Target Neighborhood Hits	644	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK3_MOUSE
θ value	θ > 10 (rank : 476)	NC score	0.054075 (rank : 401)
Query Neighborhood Hits	453	Target Neighborhood Hits	628	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

M3K10_HUMAN
θ value	θ > 10 (rank : 477)	NC score	0.050871 (rank : 418)
Query Neighborhood Hits	453	Target Neighborhood Hits	1071	Shared Neighborhood Hits	66
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K11_HUMAN
θ value	θ > 10 (rank : 478)	NC score	0.050768 (rank : 420)
Query Neighborhood Hits	453	Target Neighborhood Hits	1136	Shared Neighborhood Hits	70
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

MLKL_HUMAN
θ value	θ > 10 (rank : 479)	NC score	0.058236 (rank : 391)
Query Neighborhood Hits	453	Target Neighborhood Hits	600	Shared Neighborhood Hits	41
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLKL_MOUSE
θ value	θ > 10 (rank : 480)	NC score	0.051539 (rank : 413)
Query Neighborhood Hits	453	Target Neighborhood Hits	707	Shared Neighborhood Hits	43
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

RIPK2_HUMAN
θ value	θ > 10 (rank : 481)	NC score	0.062733 (rank : 388)
Query Neighborhood Hits	453	Target Neighborhood Hits	774	Shared Neighborhood Hits	46
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RIPK2_MOUSE
θ value	θ > 10 (rank : 482)	NC score	0.056889 (rank : 393)
Query Neighborhood Hits	453	Target Neighborhood Hits	776	Shared Neighborhood Hits	44
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK3_HUMAN
θ value	θ > 10 (rank : 483)	NC score	0.050739 (rank : 421)
Query Neighborhood Hits	453	Target Neighborhood Hits	828	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

SRC_HUMAN
θ value	θ > 10 (rank : 484)	NC score	0.050552 (rank : 422)
Query Neighborhood Hits	453	Target Neighborhood Hits	1058	Shared Neighborhood Hits	66
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
θ value	θ > 10 (rank : 485)	NC score	0.050529 (rank : 423)
Query Neighborhood Hits	453	Target Neighborhood Hits	1033	Shared Neighborhood Hits	65
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SSB4_HUMAN
θ value	θ > 10 (rank : 486)	NC score	0.053811 (rank : 403)
Query Neighborhood Hits	453	Target Neighborhood Hits	47	Shared Neighborhood Hits	25
SwissProt Accessions	Q96A44	Gene names	SPSB4, SSB4
Domain Architecture	No domain graphic available
Description	SPRY domain-containing SOCS box protein 4 (SSB-4).

TIE1_HUMAN
θ value	θ > 10 (rank : 487)	NC score	0.055075 (rank : 397)
Query Neighborhood Hits	453	Target Neighborhood Hits	1241	Shared Neighborhood Hits	55
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE1_MOUSE
θ value	θ > 10 (rank : 488)	NC score	0.055023 (rank : 398)
Query Neighborhood Hits	453	Target Neighborhood Hits	1266	Shared Neighborhood Hits	55
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE2_HUMAN
θ value	θ > 10 (rank : 489)	NC score	0.054266 (rank : 400)
Query Neighborhood Hits	453	Target Neighborhood Hits	1192	Shared Neighborhood Hits	56
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE2_MOUSE
θ value	θ > 10 (rank : 490)	NC score	0.054394 (rank : 399)
Query Neighborhood Hits	453	Target Neighborhood Hits	1204	Shared Neighborhood Hits	57
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

TNK1_HUMAN
θ value	θ > 10 (rank : 491)	NC score	0.051171 (rank : 416)
Query Neighborhood Hits	453	Target Neighborhood Hits	815	Shared Neighborhood Hits	50
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TRPC1_HUMAN
θ value	θ > 10 (rank : 492)	NC score	0.066500 (rank : 386)
Query Neighborhood Hits	453	Target Neighborhood Hits	91	Shared Neighborhood Hits	52
SwissProt Accessions	P48995	Gene names	TRPC1, TRP1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (TRP-1 protein).

TRPC1_MOUSE
θ value	θ > 10 (rank : 493)	NC score	0.061721 (rank : 389)
Query Neighborhood Hits	453	Target Neighborhood Hits	87	Shared Neighborhood Hits	48
SwissProt Accessions	Q61056, O35722	Gene names	Trpc1, Trp1, Trrp1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (Mtrp1) (Trp-related protein 1).

TRPC5_HUMAN
θ value	θ > 10 (rank : 494)	NC score	0.084437 (rank : 360)
Query Neighborhood Hits	453	Target Neighborhood Hits	122	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UL62, O75233, Q5JXY8, Q9Y514	Gene names	TRPC5, TRP5
Domain Architecture
Description	Short transient receptor potential channel 5 (TrpC5) (Htrp-5) (Htrp5).

TRPC5_MOUSE
θ value	θ > 10 (rank : 495)	NC score	0.086623 (rank : 351)
Query Neighborhood Hits	453	Target Neighborhood Hits	124	Shared Neighborhood Hits	73
SwissProt Accessions	Q9QX29, Q61059, Q9QWT1, Q9R0D4	Gene names	Trpc5, Trp5, Trrp5
Domain Architecture
Description	Short transient receptor potential channel 5 (TrpC5) (Transient receptor protein 5) (Mtrp5) (trp-related protein 5) (Capacitative calcium entry channel 2) (CCE2).

TRPV1_HUMAN
θ value	θ > 10 (rank : 496)	NC score	0.211474 (rank : 290)
Query Neighborhood Hits	453	Target Neighborhood Hits	184	Shared Neighborhood Hits	147
SwissProt Accessions	Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22	Gene names	TRPV1, VR1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Capsaicin receptor).

TRPV2_HUMAN
θ value	θ > 10 (rank : 497)	NC score	0.196683 (rank : 293)
Query Neighborhood Hits	453	Target Neighborhood Hits	130	Shared Neighborhood Hits	109
SwissProt Accessions	Q9Y5S1, Q9Y670	Gene names	TRPV2, VRL
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1).

TRPV2_MOUSE
θ value	θ > 10 (rank : 498)	NC score	0.150583 (rank : 305)
Query Neighborhood Hits	453	Target Neighborhood Hits	111	Shared Neighborhood Hits	89
SwissProt Accessions	Q9WTR1, Q99K71	Gene names	Trpv2, Grc
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Growth factor-regulated calcium channel) (GRC).

TRPV4_HUMAN
θ value	θ > 10 (rank : 499)	NC score	0.114003 (rank : 324)
Query Neighborhood Hits	453	Target Neighborhood Hits	150	Shared Neighborhood Hits	83
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TRPV4_MOUSE
θ value	θ > 10 (rank : 500)	NC score	0.105969 (rank : 329)
Query Neighborhood Hits	453	Target Neighborhood Hits	117	Shared Neighborhood Hits	78
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TXK_MOUSE
θ value	θ > 10 (rank : 501)	NC score	0.050297 (rank : 425)
Query Neighborhood Hits	453	Target Neighborhood Hits	980	Shared Neighborhood Hits	61
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

YES_HUMAN
θ value	θ > 10 (rank : 502)	NC score	0.052258 (rank : 407)
Query Neighborhood Hits	453	Target Neighborhood Hits	1059	Shared Neighborhood Hits	63
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	θ > 10 (rank : 503)	NC score	0.051937 (rank : 409)
Query Neighborhood Hits	453	Target Neighborhood Hits	1052	Shared Neighborhood Hits	62
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ZAP70_HUMAN
θ value	θ > 10 (rank : 504)	NC score	0.050780 (rank : 419)
Query Neighborhood Hits	453	Target Neighborhood Hits	893	Shared Neighborhood Hits	52
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

Hits sorted by NC score

ANKS1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	453	Target Neighborhood Hits	453	Shared Neighborhood Hits	453
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

ANKS1_HUMAN
NC score	0.991857 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	453	Target Neighborhood Hits	438	Shared Neighborhood Hits	386
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

CSKI2_HUMAN
NC score	0.890022 (rank : 3)	θ value	8.02596e-49 (rank : 3)
Query Neighborhood Hits	453	Target Neighborhood Hits	747	Shared Neighborhood Hits	360
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CSKI2_MOUSE
NC score	0.889573 (rank : 4)	θ value	1.04822e-48 (rank : 4)
Query Neighborhood Hits	453	Target Neighborhood Hits	812	Shared Neighborhood Hits	348
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

ANR29_HUMAN
NC score	0.888170 (rank : 5)	θ value	1.99529e-15 (rank : 47)
Query Neighborhood Hits	453	Target Neighborhood Hits	294	Shared Neighborhood Hits	291
SwissProt Accessions	Q8N6D5, Q6ZWE8, Q96LU9	Gene names	ANKRD29
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 29.

ANR16_HUMAN
NC score	0.887157 (rank : 6)	θ value	6.62687e-19 (rank : 33)
Query Neighborhood Hits	453	Target Neighborhood Hits	286	Shared Neighborhood Hits	281
SwissProt Accessions	Q6P6B7, Q9NT01	Gene names	ANKRD16
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 16.

ANR50_HUMAN
NC score	0.882093 (rank : 7)	θ value	2.59989e-23 (rank : 16)
Query Neighborhood Hits	453	Target Neighborhood Hits	361	Shared Neighborhood Hits	298
SwissProt Accessions	Q9ULJ7, Q6N064, Q6ZSE6	Gene names	ANKRD50, KIAA1223
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 50.

ANKR6_HUMAN
NC score	0.878206 (rank : 8)	θ value	1.86321e-21 (rank : 24)
Query Neighborhood Hits	453	Target Neighborhood Hits	439	Shared Neighborhood Hits	292
SwissProt Accessions	Q9Y2G4, Q9NU24, Q9UFQ9	Gene names	ANKRD6, KIAA0957
Domain Architecture
Description	Ankyrin repeat domain-containing protein 6.

ASB3_MOUSE
NC score	0.877947 (rank : 9)	θ value	4.58923e-20 (rank : 28)
Query Neighborhood Hits	453	Target Neighborhood Hits	316	Shared Neighborhood Hits	294
SwissProt Accessions	Q9WV72	Gene names	Asb3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

PSD10_HUMAN
NC score	0.877324 (rank : 10)	θ value	4.91457e-14 (rank : 57)
Query Neighborhood Hits	453	Target Neighborhood Hits	301	Shared Neighborhood Hits	292
SwissProt Accessions	O75832	Gene names	PSMD10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

ASB3_HUMAN
NC score	0.875545 (rank : 11)	θ value	5.07402e-19 (rank : 30)
Query Neighborhood Hits	453	Target Neighborhood Hits	316	Shared Neighborhood Hits	296
SwissProt Accessions	Q9Y575, Q9NVZ2	Gene names	ASB3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

PSD10_MOUSE
NC score	0.875360 (rank : 12)	θ value	1.09485e-13 (rank : 61)
Query Neighborhood Hits	453	Target Neighborhood Hits	293	Shared Neighborhood Hits	289
SwissProt Accessions	Q9Z2X2, Q9D7N8	Gene names	Psmd10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

CSKI1_HUMAN
NC score	0.872711 (rank : 13)	θ value	8.30557e-46 (rank : 5)
Query Neighborhood Hits	453	Target Neighborhood Hits	997	Shared Neighborhood Hits	348
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI1_MOUSE
NC score	0.872490 (rank : 14)	θ value	1.41672e-45 (rank : 6)
Query Neighborhood Hits	453	Target Neighborhood Hits	1031	Shared Neighborhood Hits	351
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

ANR44_HUMAN
NC score	0.871997 (rank : 15)	θ value	5.79196e-23 (rank : 17)
Query Neighborhood Hits	453	Target Neighborhood Hits	318	Shared Neighborhood Hits	298
SwissProt Accessions	Q8N8A2, Q6P480, Q86VL5, Q8IZ72, Q9UFA4	Gene names	ANKRD44
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 44.

ANR42_HUMAN
NC score	0.871890 (rank : 16)	θ value	1.80466e-16 (rank : 42)
Query Neighborhood Hits	453	Target Neighborhood Hits	284	Shared Neighborhood Hits	279
SwissProt Accessions	Q8N9B4, Q49A49	Gene names	ANKRD42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

INVS_HUMAN
NC score	0.871560 (rank : 17)	θ value	1.29031e-22 (rank : 21)
Query Neighborhood Hits	453	Target Neighborhood Hits	455	Shared Neighborhood Hits	294
SwissProt Accessions	Q9Y283, Q5W0T6, Q8IVX8, Q9BRB9, Q9Y488, Q9Y498	Gene names	INVS, INV, NPHP2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning homolog) (Nephrocystin-2).

ANR28_MOUSE
NC score	0.871497 (rank : 18)	θ value	9.54697e-26 (rank : 12)
Query Neighborhood Hits	453	Target Neighborhood Hits	314	Shared Neighborhood Hits	297
SwissProt Accessions	Q505D1	Gene names	Ankrd28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ASB7_MOUSE
NC score	0.870825 (rank : 19)	θ value	1.38178e-16 (rank : 41)
Query Neighborhood Hits	453	Target Neighborhood Hits	296	Shared Neighborhood Hits	283
SwissProt Accessions	Q91ZU0	Gene names	Asb7
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 7 (ASB-7).

ANK1_HUMAN
NC score	0.870593 (rank : 20)	θ value	1.33217e-27 (rank : 8)
Query Neighborhood Hits	453	Target Neighborhood Hits	416	Shared Neighborhood Hits	301
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

ANR28_HUMAN
NC score	0.870389 (rank : 21)	θ value	3.62785e-25 (rank : 13)
Query Neighborhood Hits	453	Target Neighborhood Hits	314	Shared Neighborhood Hits	295
SwissProt Accessions	O15084, Q6ULS0, Q6ZT57	Gene names	ANKRD28, KIAA0379
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ASB7_HUMAN
NC score	0.870252 (rank : 22)	θ value	6.85773e-16 (rank : 45)
Query Neighborhood Hits	453	Target Neighborhood Hits	296	Shared Neighborhood Hits	283
SwissProt Accessions	Q9H672, Q7Z4S3	Gene names	ASB7
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 7 (ASB-7).

ANK1_MOUSE
NC score	0.869599 (rank : 23)	θ value	8.3442e-30 (rank : 7)
Query Neighborhood Hits	453	Target Neighborhood Hits	430	Shared Neighborhood Hits	303
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

ANR42_MOUSE
NC score	0.868642 (rank : 24)	θ value	6.85773e-16 (rank : 44)
Query Neighborhood Hits	453	Target Neighborhood Hits	334	Shared Neighborhood Hits	282
SwissProt Accessions	Q3V096, Q8BX55, Q8BZT3, Q8C0T6, Q8C0X5	Gene names	Ankrd42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

TNKS1_HUMAN
NC score	0.866712 (rank : 25)	θ value	2.20094e-22 (rank : 22)
Query Neighborhood Hits	453	Target Neighborhood Hits	477	Shared Neighborhood Hits	326
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

ASB10_MOUSE
NC score	0.866611 (rank : 26)	θ value	6.62687e-19 (rank : 34)
Query Neighborhood Hits	453	Target Neighborhood Hits	301	Shared Neighborhood Hits	284
SwissProt Accessions	Q91ZT7	Gene names	Asb10
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

TNKS2_HUMAN
NC score	0.866442 (rank : 27)	θ value	7.56453e-23 (rank : 20)
Query Neighborhood Hits	453	Target Neighborhood Hits	361	Shared Neighborhood Hits	308
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

ANR52_MOUSE
NC score	0.865275 (rank : 28)	θ value	7.56453e-23 (rank : 18)
Query Neighborhood Hits	453	Target Neighborhood Hits	318	Shared Neighborhood Hits	299
SwissProt Accessions	Q8BTI7	Gene names	Ankrd52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ANR52_HUMAN
NC score	0.864557 (rank : 29)	θ value	2.87452e-22 (rank : 23)
Query Neighborhood Hits	453	Target Neighborhood Hits	322	Shared Neighborhood Hits	299
SwissProt Accessions	Q8NB46	Gene names	ANKRD52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ASB10_HUMAN
NC score	0.864357 (rank : 30)	θ value	8.10077e-17 (rank : 40)
Query Neighborhood Hits	453	Target Neighborhood Hits	291	Shared Neighborhood Hits	282
SwissProt Accessions	Q8WXI3	Gene names	ASB10
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

INVS_MOUSE
NC score	0.863137 (rank : 31)	θ value	7.56453e-23 (rank : 19)
Query Neighborhood Hits	453	Target Neighborhood Hits	609	Shared Neighborhood Hits	303
SwissProt Accessions	O89019, O88849	Gene names	Invs, Inv, Nphp2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning protein) (Nephrocystin-2).

FANK1_HUMAN
NC score	0.861918 (rank : 32)	θ value	4.16044e-13 (rank : 66)
Query Neighborhood Hits	453	Target Neighborhood Hits	326	Shared Neighborhood Hits	291
SwissProt Accessions	Q8TC84, Q6UXY9, Q6X7T6	Gene names	FANK1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains protein 1.

FANK1_MOUSE
NC score	0.859665 (rank : 33)	θ value	7.84624e-12 (rank : 76)
Query Neighborhood Hits	453	Target Neighborhood Hits	325	Shared Neighborhood Hits	289
SwissProt Accessions	Q9DAM9, Q9CUA7	Gene names	Fank1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains 1 protein (Germ cell- specific gene 1 protein) (GSG1).

ANK3_HUMAN
NC score	0.857301 (rank : 34)	θ value	1.73987e-27 (rank : 9)
Query Neighborhood Hits	453	Target Neighborhood Hits	853	Shared Neighborhood Hits	311
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

ASB2_HUMAN
NC score	0.856190 (rank : 35)	θ value	2.7842e-17 (rank : 37)
Query Neighborhood Hits	453	Target Neighborhood Hits	309	Shared Neighborhood Hits	288
SwissProt Accessions	Q96Q27, Q9NSU5, Q9Y567	Gene names	ASB2
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 2 (ASB-2).

ASB13_MOUSE
NC score	0.853798 (rank : 36)	θ value	2.7842e-17 (rank : 36)
Query Neighborhood Hits	453	Target Neighborhood Hits	293	Shared Neighborhood Hits	281
SwissProt Accessions	Q8VBX0	Gene names	Asb13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 13 (ASB-13).

ASB13_HUMAN
NC score	0.853668 (rank : 37)	θ value	4.74913e-17 (rank : 38)
Query Neighborhood Hits	453	Target Neighborhood Hits	293	Shared Neighborhood Hits	283
SwissProt Accessions	Q8WXK3, Q96EP7, Q9H8Z1	Gene names	ASB13
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 13 (ASB-13).

ANKR2_MOUSE
NC score	0.851422 (rank : 38)	θ value	1.09485e-13 (rank : 60)
Query Neighborhood Hits	453	Target Neighborhood Hits	312	Shared Neighborhood Hits	289
SwissProt Accessions	Q9WV06	Gene names	Ankrd2, Arpp
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (mArpp).

ASB2_MOUSE
NC score	0.851176 (rank : 39)	θ value	5.25075e-16 (rank : 43)
Query Neighborhood Hits	453	Target Neighborhood Hits	321	Shared Neighborhood Hits	287
SwissProt Accessions	Q8K0L0, Q9CTH4, Q9WV73	Gene names	Asb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 2 (ASB-2).

TRPA1_MOUSE
NC score	0.850741 (rank : 40)	θ value	4.29542e-18 (rank : 35)
Query Neighborhood Hits	453	Target Neighborhood Hits	343	Shared Neighborhood Hits	292
SwissProt Accessions	Q8BLA8	Gene names	Trpa1, Anktm1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1).

ANR23_MOUSE
NC score	0.850298 (rank : 41)	θ value	3.52202e-12 (rank : 71)
Query Neighborhood Hits	453	Target Neighborhood Hits	296	Shared Neighborhood Hits	286
SwissProt Accessions	Q812A3	Gene names	Ankrd23, Darp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein).

TRPA1_HUMAN
NC score	0.850029 (rank : 42)	θ value	6.20254e-17 (rank : 39)
Query Neighborhood Hits	453	Target Neighborhood Hits	339	Shared Neighborhood Hits	292
SwissProt Accessions	O75762	Gene names	TRPA1, ANKTM1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation sensitive-protein p120).

ANR39_HUMAN
NC score	0.849011 (rank : 43)	θ value	5.08577e-11 (rank : 84)
Query Neighborhood Hits	453	Target Neighborhood Hits	285	Shared Neighborhood Hits	280
SwissProt Accessions	Q53RE8, Q59FU2, Q8N5X5, Q9P0S5	Gene names	ANKRD39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ANR39_MOUSE
NC score	0.847753 (rank : 44)	θ value	5.08577e-11 (rank : 85)
Query Neighborhood Hits	453	Target Neighborhood Hits	284	Shared Neighborhood Hits	279
SwissProt Accessions	Q9D2X0	Gene names	Ankrd39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ANKR2_HUMAN
NC score	0.846700 (rank : 45)	θ value	2.28291e-11 (rank : 81)
Query Neighborhood Hits	453	Target Neighborhood Hits	321	Shared Neighborhood Hits	288
SwissProt Accessions	Q9GZV1, Q5T456, Q8WUD7	Gene names	ANKRD2, ARPP
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp).

ANR23_HUMAN
NC score	0.844377 (rank : 46)	θ value	2.28291e-11 (rank : 83)
Query Neighborhood Hits	453	Target Neighborhood Hits	291	Shared Neighborhood Hits	283
SwissProt Accessions	Q86SG2, Q711K7, Q8NAJ7	Gene names	ANKRD23, DARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein) (Muscle ankyrin repeat protein 3).

ANKS6_MOUSE
NC score	0.843609 (rank : 47)	θ value	1.42992e-13 (rank : 63)
Query Neighborhood Hits	453	Target Neighborhood Hits	435	Shared Neighborhood Hits	306
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

ANKS6_HUMAN
NC score	0.842326 (rank : 48)	θ value	3.18553e-13 (rank : 65)
Query Neighborhood Hits	453	Target Neighborhood Hits	411	Shared Neighborhood Hits	303
SwissProt Accessions	Q68DC2, Q5VSL0, Q5VSL2, Q5VSL3, Q5VSL4, Q68DB8, Q6P2R2, Q8N9L6, Q96D62	Gene names	ANKS6, ANKRD14, SAMD6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6) (Ankyrin repeat domain-containing protein 14).

ANKR1_HUMAN
NC score	0.842111 (rank : 49)	θ value	3.52202e-12 (rank : 70)
Query Neighborhood Hits	453	Target Neighborhood Hits	308	Shared Neighborhood Hits	281
SwissProt Accessions	Q15327, Q96LE7	Gene names	ANKRD1, C193, CARP, HA1A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) (Cytokine-inducible nuclear protein) (C-193).

ANKR1_MOUSE
NC score	0.839715 (rank : 50)	θ value	3.29651e-10 (rank : 95)
Query Neighborhood Hits	453	Target Neighborhood Hits	316	Shared Neighborhood Hits	289
SwissProt Accessions	Q9CR42, O55014, Q3UIF7, Q3UJ39, Q792Q9	Gene names	Ankrd1, Carp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein).

GABP2_MOUSE
NC score	0.837815 (rank : 51)	θ value	3.29651e-10 (rank : 97)
Query Neighborhood Hits	453	Target Neighborhood Hits	429	Shared Neighborhood Hits	292
SwissProt Accessions	Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2	Gene names	Gabpb2, Gabpb, Gabpb1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1).

ASB8_MOUSE
NC score	0.834993 (rank : 52)	θ value	2.13673e-09 (rank : 113)
Query Neighborhood Hits	453	Target Neighborhood Hits	293	Shared Neighborhood Hits	280
SwissProt Accessions	Q91ZT9, Q8R178	Gene names	Asb8
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 8 (ASB-8).

CDN2C_HUMAN
NC score	0.834336 (rank : 53)	θ value	8.11959e-09 (rank : 124)
Query Neighborhood Hits	453	Target Neighborhood Hits	262	Shared Neighborhood Hits	262
SwissProt Accessions	P42773, Q8TB83	Gene names	CDKN2C, CDKN6
Domain Architecture
Description	Cyclin-dependent kinase 6 inhibitor (p18-INK6) (Cyclin-dependent kinase 4 inhibitor C) (p18-INK4c).

GABP2_HUMAN
NC score	0.834225 (rank : 54)	θ value	2.13673e-09 (rank : 114)
Query Neighborhood Hits	453	Target Neighborhood Hits	454	Shared Neighborhood Hits	292
SwissProt Accessions	Q06547, Q06545, Q12940, Q12941, Q12942, Q8IYD0	Gene names	GABPB2, E4TF1B, GABPB, GABPB1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1) (Transcription factor E4TF1-53) (Transcription factor E4TF1-47) (Nuclear respiratory factor 2).

ASB8_HUMAN
NC score	0.833851 (rank : 55)	θ value	2.79066e-09 (rank : 117)
Query Neighborhood Hits	453	Target Neighborhood Hits	294	Shared Neighborhood Hits	281
SwissProt Accessions	Q9H765, Q547Q2	Gene names	ASB8
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 8 (ASB-8).

CDN2C_MOUSE
NC score	0.833552 (rank : 56)	θ value	2.79066e-09 (rank : 118)
Query Neighborhood Hits	453	Target Neighborhood Hits	270	Shared Neighborhood Hits	268
SwissProt Accessions	Q60772	Gene names	Cdkn2c
Domain Architecture
Description	Cyclin-dependent kinase 6 inhibitor (p18-INK6) (Cyclin-dependent kinase 4 inhibitor C) (p18-INK4c).

GABP3_MOUSE
NC score	0.833265 (rank : 57)	θ value	5.26297e-08 (rank : 140)
Query Neighborhood Hits	453	Target Neighborhood Hits	330	Shared Neighborhood Hits	279
SwissProt Accessions	P81069	Gene names	Gabpb2
Domain Architecture	No domain graphic available
Description	GA-binding protein beta-2-1 chain (GABP subunit beta-2-1) (GABPB2-1).

BCL3_HUMAN
NC score	0.833085 (rank : 58)	θ value	4.30538e-10 (rank : 101)
Query Neighborhood Hits	453	Target Neighborhood Hits	324	Shared Neighborhood Hits	283
SwissProt Accessions	P20749	Gene names	BCL3
Domain Architecture
Description	B-cell lymphoma 3-encoded protein (Protein Bcl-3).

MIB1_HUMAN
NC score	0.830816 (rank : 59)	θ value	5.07402e-19 (rank : 31)
Query Neighborhood Hits	453	Target Neighborhood Hits	470	Shared Neighborhood Hits	295
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

MIB1_MOUSE
NC score	0.830377 (rank : 60)	θ value	5.07402e-19 (rank : 32)
Query Neighborhood Hits	453	Target Neighborhood Hits	471	Shared Neighborhood Hits	296
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

BCL3_MOUSE
NC score	0.829628 (rank : 61)	θ value	4.30538e-10 (rank : 102)
Query Neighborhood Hits	453	Target Neighborhood Hits	388	Shared Neighborhood Hits	287
SwissProt Accessions	Q9Z2F6	Gene names	Bcl3
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 3-encoded protein homolog (Protein Bcl-3).

ASB15_HUMAN
NC score	0.828427 (rank : 62)	θ value	1.33837e-11 (rank : 80)
Query Neighborhood Hits	453	Target Neighborhood Hits	305	Shared Neighborhood Hits	280
SwissProt Accessions	Q8WXK1	Gene names	ASB15
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 15 (ASB-15).

ANR49_MOUSE
NC score	0.828125 (rank : 63)	θ value	2.21117e-06 (rank : 176)
Query Neighborhood Hits	453	Target Neighborhood Hits	285	Shared Neighborhood Hits	279
SwissProt Accessions	Q8VE42, Q9Z2S1	Gene names	Ankrd49, Fgif, Gbif
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor) (Fetal globin-increasing factor).

ASB16_MOUSE
NC score	0.827847 (rank : 64)	θ value	1.9326e-10 (rank : 90)
Query Neighborhood Hits	453	Target Neighborhood Hits	306	Shared Neighborhood Hits	279
SwissProt Accessions	Q8VHS5, Q8BYT0	Gene names	Asb16
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 16 (ASB-16).

ANKS3_MOUSE
NC score	0.827774 (rank : 65)	θ value	2.28291e-11 (rank : 82)
Query Neighborhood Hits	453	Target Neighborhood Hits	355	Shared Neighborhood Hits	283
SwissProt Accessions	Q9CZK6, Q6ZPF6, Q80X46	Gene names	Anks3, Kiaa1977
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 3.

PA2G6_MOUSE
NC score	0.827095 (rank : 66)	θ value	1.38499e-08 (rank : 130)
Query Neighborhood Hits	453	Target Neighborhood Hits	293	Shared Neighborhood Hits	282
SwissProt Accessions	P97819, Q99LA9, Q9JK61	Gene names	Pla2g6
Domain Architecture
Description	85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4) (iPLA2) (CaI- PLA2) (Group VI phospholipase A2) (GVI PLA2).

MYPT1_MOUSE
NC score	0.826551 (rank : 67)	θ value	1.29331e-14 (rank : 53)
Query Neighborhood Hits	453	Target Neighborhood Hits	539	Shared Neighborhood Hits	290
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

PP16A_MOUSE
NC score	0.825778 (rank : 68)	θ value	6.00763e-12 (rank : 75)
Query Neighborhood Hits	453	Target Neighborhood Hits	318	Shared Neighborhood Hits	283
SwissProt Accessions	Q923M0, Q4V9Z1	Gene names	Ppp1r16a, Mypt3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase targeting subunit 3).

ANR49_HUMAN
NC score	0.825740 (rank : 69)	θ value	9.92553e-07 (rank : 168)
Query Neighborhood Hits	453	Target Neighborhood Hits	282	Shared Neighborhood Hits	276
SwissProt Accessions	Q8WVL7, Q8NDF2, Q96JE5, Q9NXK7	Gene names	ANKRD49, FGIF
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor).

ASB14_MOUSE
NC score	0.824393 (rank : 70)	θ value	2.60593e-15 (rank : 49)
Query Neighborhood Hits	453	Target Neighborhood Hits	293	Shared Neighborhood Hits	274
SwissProt Accessions	Q8VHS7	Gene names	Asb14
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 14 (ASB-14).

IKBA_HUMAN
NC score	0.821602 (rank : 71)	θ value	3.40345e-15 (rank : 50)
Query Neighborhood Hits	453	Target Neighborhood Hits	280	Shared Neighborhood Hits	270
SwissProt Accessions	P25963	Gene names	NFKBIA, IKBA, MAD3, NFKBI
Domain Architecture
Description	NF-kappa-B inhibitor alpha (Major histocompatibility complex enhancer- binding protein MAD3) (I-kappa-B-alpha) (IkappaBalpha) (IKB-alpha).

ANKS3_HUMAN
NC score	0.821251 (rank : 72)	θ value	2.79066e-09 (rank : 116)
Query Neighborhood Hits	453	Target Neighborhood Hits	355	Shared Neighborhood Hits	282
SwissProt Accessions	Q6ZW76, Q8TF25	Gene names	ANKS3, KIAA1977
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 3.

ASB9_HUMAN
NC score	0.820872 (rank : 73)	θ value	3.52202e-12 (rank : 72)
Query Neighborhood Hits	453	Target Neighborhood Hits	267	Shared Neighborhood Hits	259
SwissProt Accessions	Q96DX5, Q9NWS5, Q9Y4T3	Gene names	ASB9
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 9 (ASB-9).

PP16A_HUMAN
NC score	0.820309 (rank : 74)	θ value	1.02475e-11 (rank : 79)
Query Neighborhood Hits	453	Target Neighborhood Hits	340	Shared Neighborhood Hits	278
SwissProt Accessions	Q96I34	Gene names	PPP1R16A, MYPT3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase- targeting subunit 3).

ASB15_MOUSE
NC score	0.818933 (rank : 75)	θ value	4.30538e-10 (rank : 100)
Query Neighborhood Hits	453	Target Neighborhood Hits	292	Shared Neighborhood Hits	272
SwissProt Accessions	Q8VHS6	Gene names	Asb15
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 15 (ASB-15).

ASB16_HUMAN
NC score	0.818306 (rank : 76)	θ value	1.38499e-08 (rank : 128)
Query Neighborhood Hits	453	Target Neighborhood Hits	286	Shared Neighborhood Hits	268
SwissProt Accessions	Q96NS5, Q8WXK0	Gene names	ASB16
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 16 (ASB-16).

CDN2D_HUMAN
NC score	0.818268 (rank : 77)	θ value	3.41135e-07 (rank : 158)
Query Neighborhood Hits	453	Target Neighborhood Hits	268	Shared Neighborhood Hits	267
SwissProt Accessions	P55273, Q13102, Q6FGE9	Gene names	CDKN2D
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

MIB2_MOUSE
NC score	0.818061 (rank : 78)	θ value	8.38298e-14 (rank : 59)
Query Neighborhood Hits	453	Target Neighborhood Hits	409	Shared Neighborhood Hits	278
SwissProt Accessions	Q8R516, Q52QU8, Q6PEF6, Q8C1N7, Q8VIB4	Gene names	Mib2, Skd
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) (Dystrophin-like protein) (Dyslike).

MIB2_HUMAN
NC score	0.818024 (rank : 79)	θ value	3.76295e-14 (rank : 56)
Query Neighborhood Hits	453	Target Neighborhood Hits	438	Shared Neighborhood Hits	287
SwissProt Accessions	Q96AX9, Q7Z437, Q8IY62, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1	Gene names	MIB2, SKD, ZZANK1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N).

ASZ1_HUMAN
NC score	0.815815 (rank : 80)	θ value	1.80886e-08 (rank : 132)
Query Neighborhood Hits	453	Target Neighborhood Hits	341	Shared Neighborhood Hits	279
SwissProt Accessions	Q8WWH4	Gene names	ASZ1, GASZ
Domain Architecture
Description	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).

PA2G6_HUMAN
NC score	0.814651 (rank : 81)	θ value	5.26297e-08 (rank : 142)
Query Neighborhood Hits	453	Target Neighborhood Hits	284	Shared Neighborhood Hits	275
SwissProt Accessions	O60733, O75645, Q8N452, Q9UG29, Q9UIT0, Q9Y671	Gene names	PLA2G6, IPLA2
Domain Architecture
Description	85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4) (iPLA2) (CaI- PLA2) (Group VI phospholipase A2) (GVI PLA2).

ANRA2_HUMAN
NC score	0.814350 (rank : 82)	θ value	6.21693e-09 (rank : 119)
Query Neighborhood Hits	453	Target Neighborhood Hits	288	Shared Neighborhood Hits	281
SwissProt Accessions	Q9H9E1	Gene names	ANKRA2, ANKRA
Domain Architecture
Description	Ankyrin repeat family A protein 2 (RFXANK-like 2).

ASB11_HUMAN
NC score	0.813773 (rank : 83)	θ value	1.133e-10 (rank : 87)
Query Neighborhood Hits	453	Target Neighborhood Hits	271	Shared Neighborhood Hits	261
SwissProt Accessions	Q8WXH4, Q3SYC4	Gene names	ASB11
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 11 (ASB-11).

PP16B_HUMAN
NC score	0.813474 (rank : 84)	θ value	8.11959e-09 (rank : 125)
Query Neighborhood Hits	453	Target Neighborhood Hits	307	Shared Neighborhood Hits	283
SwissProt Accessions	Q96T49, O94912, Q9NQG4	Gene names	PPP1R16B, ANKRD4, KIAA0823
Domain Architecture
Description	Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein) (hTIMAP) (CAAX box protein TIMAP) (Ankyrin repeat domain protein 4).

ANKR5_MOUSE
NC score	0.812823 (rank : 85)	θ value	5.26297e-08 (rank : 139)
Query Neighborhood Hits	453	Target Neighborhood Hits	298	Shared Neighborhood Hits	283
SwissProt Accessions	Q9D2J7	Gene names	Ankrd5
Domain Architecture
Description	Ankyrin repeat domain-containing protein 5.

ASB11_MOUSE
NC score	0.812296 (rank : 86)	θ value	3.29651e-10 (rank : 96)
Query Neighborhood Hits	453	Target Neighborhood Hits	271	Shared Neighborhood Hits	257
SwissProt Accessions	Q9CQ31, Q3UJ13, Q9D0V1	Gene names	Asb11
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 11 (ASB-11).

ASZ1_MOUSE
NC score	0.811842 (rank : 87)	θ value	5.81887e-07 (rank : 166)
Query Neighborhood Hits	453	Target Neighborhood Hits	319	Shared Neighborhood Hits	280
SwissProt Accessions	Q8VD46, Q9JKQ7	Gene names	Asz1, Gasz
Domain Architecture
Description	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).

ANKR5_HUMAN
NC score	0.810961 (rank : 88)	θ value	1.17247e-07 (rank : 147)
Query Neighborhood Hits	453	Target Neighborhood Hits	297	Shared Neighborhood Hits	283
SwissProt Accessions	Q9NU02, Q9H6Y9	Gene names	ANKRD5
Domain Architecture
Description	Ankyrin repeat domain-containing protein 5.

PP16B_MOUSE
NC score	0.810939 (rank : 89)	θ value	4.0297e-08 (rank : 137)
Query Neighborhood Hits	453	Target Neighborhood Hits	302	Shared Neighborhood Hits	281
SwissProt Accessions	Q8VHQ3	Gene names	Ppp1r16b
Domain Architecture
Description	Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein) (CAAX box protein TIMAP).

ANRA2_MOUSE
NC score	0.809984 (rank : 90)	θ value	4.45536e-07 (rank : 163)
Query Neighborhood Hits	453	Target Neighborhood Hits	287	Shared Neighborhood Hits	281
SwissProt Accessions	Q99PE2	Gene names	Ankra2, Ankra
Domain Architecture
Description	Ankyrin repeat family A protein 2 (RFXANK-like 2).

MYPT2_HUMAN
NC score	0.809911 (rank : 91)	θ value	4.59992e-12 (rank : 73)
Query Neighborhood Hits	453	Target Neighborhood Hits	707	Shared Neighborhood Hits	294
SwissProt Accessions	O60237, Q8N179, Q9HCB7, Q9HCB8	Gene names	PPP1R12B, MYPT2
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase- targeting subunit 2) (Myosin phosphatase target subunit 2).

IKBA_MOUSE
NC score	0.809903 (rank : 92)	θ value	8.38298e-14 (rank : 58)
Query Neighborhood Hits	453	Target Neighborhood Hits	283	Shared Neighborhood Hits	270
SwissProt Accessions	Q9Z1E3, Q80ZX5	Gene names	Nfkbia, Ikba
Domain Architecture	No domain graphic available
Description	NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkappaBalpha) (IKB- alpha).

ASB5_HUMAN
NC score	0.809624 (rank : 93)	θ value	1.53129e-07 (rank : 153)
Query Neighborhood Hits	453	Target Neighborhood Hits	283	Shared Neighborhood Hits	272
SwissProt Accessions	Q8WWX0	Gene names	ASB5
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 5 (ASB-5).

CDN2D_MOUSE
NC score	0.809556 (rank : 94)	θ value	3.41135e-07 (rank : 159)
Query Neighborhood Hits	453	Target Neighborhood Hits	267	Shared Neighborhood Hits	266
SwissProt Accessions	Q60773, Q60794	Gene names	Cdkn2d
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

RFXK_HUMAN
NC score	0.808524 (rank : 95)	θ value	2.52405e-10 (rank : 94)
Query Neighborhood Hits	453	Target Neighborhood Hits	282	Shared Neighborhood Hits	266
SwissProt Accessions	O14593, O95839	Gene names	RFXANK, ANKRA1, RFXB
Domain Architecture
Description	DNA-binding protein RFXANK (Regulatory factor X subunit B) (RFX-B) (Ankyrin repeat family A protein 1).

MTPN_MOUSE
NC score	0.807501 (rank : 96)	θ value	0.000786445 (rank : 258)
Query Neighborhood Hits	453	Target Neighborhood Hits	269	Shared Neighborhood Hits	269
SwissProt Accessions	P62774, P80144, Q543M6, Q9DCN8	Gene names	Mtpn, Gcdp
Domain Architecture	No domain graphic available
Description	Myotrophin (Protein V-1) (Granule cell differentiation protein).

ASB5_MOUSE
NC score	0.806464 (rank : 97)	θ value	8.97725e-08 (rank : 146)
Query Neighborhood Hits	453	Target Neighborhood Hits	266	Shared Neighborhood Hits	260
SwissProt Accessions	Q9D1A4	Gene names	Asb5
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 5 (ASB-5).

ASB12_MOUSE
NC score	0.806434 (rank : 98)	θ value	4.30538e-10 (rank : 99)
Query Neighborhood Hits	453	Target Neighborhood Hits	261	Shared Neighborhood Hits	258
SwissProt Accessions	Q9D738	Gene names	Asb12
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 12 (ASB-12).

ASB9_MOUSE
NC score	0.806037 (rank : 99)	θ value	1.38499e-08 (rank : 129)
Query Neighborhood Hits	453	Target Neighborhood Hits	257	Shared Neighborhood Hits	252
SwissProt Accessions	Q91ZT8, Q9DAF7	Gene names	Asb9
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 9 (ASB-9).

ANKR7_HUMAN
NC score	0.805969 (rank : 100)	θ value	1.17247e-07 (rank : 148)
Query Neighborhood Hits	453	Target Neighborhood Hits	286	Shared Neighborhood Hits	280
SwissProt Accessions	Q92527, Q96QN1, Q9UDM3	Gene names	ANKRD7
Domain Architecture
Description	Ankyrin repeat domain-containing protein 7 (Testis-specific protein TSA806).

MYPT1_HUMAN
NC score	0.805831 (rank : 101)	θ value	6.00763e-12 (rank : 74)
Query Neighborhood Hits	453	Target Neighborhood Hits	723	Shared Neighborhood Hits	292
SwissProt Accessions	O14974, Q86WU3, Q8NFR6, Q9BYH0	Gene names	PPP1R12A, MBS, MYPT1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit).

ANR10_MOUSE
NC score	0.805676 (rank : 102)	θ value	1.06045e-08 (rank : 126)
Query Neighborhood Hits	453	Target Neighborhood Hits	273	Shared Neighborhood Hits	264
SwissProt Accessions	Q99LW0	Gene names	Ankrd10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

ASB12_HUMAN
NC score	0.804936 (rank : 103)	θ value	5.62301e-10 (rank : 105)
Query Neighborhood Hits	453	Target Neighborhood Hits	263	Shared Neighborhood Hits	263
SwissProt Accessions	Q8WXK4, Q52LK4, Q6ISF9	Gene names	ASB12
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 12 (ASB-12).

RN5A_HUMAN
NC score	0.804916 (rank : 104)	θ value	1.47974e-10 (rank : 89)
Query Neighborhood Hits	453	Target Neighborhood Hits	608	Shared Neighborhood Hits	299
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

ANR10_HUMAN
NC score	0.804437 (rank : 105)	θ value	4.0297e-08 (rank : 136)
Query Neighborhood Hits	453	Target Neighborhood Hits	289	Shared Neighborhood Hits	264
SwissProt Accessions	Q9NXR5	Gene names	ANKRD10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

MTPN_HUMAN
NC score	0.804368 (rank : 106)	θ value	0.000786445 (rank : 257)
Query Neighborhood Hits	453	Target Neighborhood Hits	269	Shared Neighborhood Hits	269
SwissProt Accessions	P58546	Gene names	MTPN
Domain Architecture
Description	Myotrophin (Protein V-1).

ANK2_HUMAN
NC score	0.804064 (rank : 107)	θ value	1.92365e-26 (rank : 10)
Query Neighborhood Hits	453	Target Neighborhood Hits	1615	Shared Neighborhood Hits	340
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

ASB4_HUMAN
NC score	0.803982 (rank : 108)	θ value	6.21693e-09 (rank : 120)
Query Neighborhood Hits	453	Target Neighborhood Hits	264	Shared Neighborhood Hits	256
SwissProt Accessions	Q9Y574, O14586	Gene names	ASB4
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 4 (ASB-4).

EHMT1_HUMAN
NC score	0.802968 (rank : 109)	θ value	1.52774e-15 (rank : 46)
Query Neighborhood Hits	453	Target Neighborhood Hits	417	Shared Neighborhood Hits	299
SwissProt Accessions	Q9H9B1, Q8TCN7, Q96F53, Q96JF1, Q96KH4	Gene names	EHMT1, EUHMTASE1, KIAA1876
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a- like protein 1) (GLP1).

ASB4_MOUSE
NC score	0.802316 (rank : 110)	θ value	1.06045e-08 (rank : 127)
Query Neighborhood Hits	453	Target Neighborhood Hits	265	Shared Neighborhood Hits	256
SwissProt Accessions	Q9WV71	Gene names	Asb4
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 4 (ASB-4).

ANR22_HUMAN
NC score	0.800091 (rank : 111)	θ value	1.69304e-06 (rank : 172)
Query Neighborhood Hits	453	Target Neighborhood Hits	243	Shared Neighborhood Hits	241
SwissProt Accessions	Q5VYY1, Q8WU06	Gene names	ANKRD22
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 22.

ASB1_HUMAN
NC score	0.797326 (rank : 112)	θ value	2.36244e-08 (rank : 134)
Query Neighborhood Hits	453	Target Neighborhood Hits	291	Shared Neighborhood Hits	279
SwissProt Accessions	Q9Y576, Q9ULS4	Gene names	ASB1, KIAA1146
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 1 (ASB-1).

RFXK_MOUSE
NC score	0.796298 (rank : 113)	θ value	3.08544e-08 (rank : 135)
Query Neighborhood Hits	453	Target Neighborhood Hits	273	Shared Neighborhood Hits	267
SwissProt Accessions	Q9Z205	Gene names	Rfxank, Rfxb, Tvl1
Domain Architecture
Description	DNA-binding protein RFXANK (Regulatory factor X subunit B) (RFX-B) (Regulatory factor X-associated ankyrin-containing protein) (Ankyrin repeat-containing adapter protein Tvl-1).

ASB1_MOUSE
NC score	0.795838 (rank : 114)	θ value	1.99992e-07 (rank : 154)
Query Neighborhood Hits	453	Target Neighborhood Hits	292	Shared Neighborhood Hits	279
SwissProt Accessions	Q9WV74	Gene names	Asb1
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 1 (ASB-1).

CT086_HUMAN
NC score	0.794620 (rank : 115)	θ value	0.00509761 (rank : 296)
Query Neighborhood Hits	453	Target Neighborhood Hits	277	Shared Neighborhood Hits	270
SwissProt Accessions	Q9BZ19, Q4VXE6	Gene names	C20orf86
Domain Architecture
Description	Putative uncharacterized protein C20orf86.

ANR46_HUMAN
NC score	0.794352 (rank : 116)	θ value	5.44631e-05 (rank : 218)
Query Neighborhood Hits	453	Target Neighborhood Hits	281	Shared Neighborhood Hits	272
SwissProt Accessions	Q86W74, Q6P9B7	Gene names	ANKRD46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

EHMT2_HUMAN
NC score	0.790585 (rank : 117)	θ value	7.58209e-15 (rank : 51)
Query Neighborhood Hits	453	Target Neighborhood Hits	498	Shared Neighborhood Hits	300
SwissProt Accessions	Q96KQ7, Q14349, Q6PK06, Q96MH5, Q96QD0, Q9UQL8, Q9Y331	Gene names	EHMT2, BAT8, G9A, NG36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

BARD1_HUMAN
NC score	0.787985 (rank : 118)	θ value	5.62301e-10 (rank : 106)
Query Neighborhood Hits	453	Target Neighborhood Hits	427	Shared Neighborhood Hits	289
SwissProt Accessions	Q99728, O43574	Gene names	BARD1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

ANR46_MOUSE
NC score	0.787519 (rank : 119)	θ value	0.000270298 (rank : 240)
Query Neighborhood Hits	453	Target Neighborhood Hits	274	Shared Neighborhood Hits	266
SwissProt Accessions	Q8BTZ5, Q1LZK9, Q8BV97	Gene names	Ankrd46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

IKBE_MOUSE
NC score	0.786769 (rank : 120)	θ value	3.19293e-05 (rank : 204)
Query Neighborhood Hits	453	Target Neighborhood Hits	308	Shared Neighborhood Hits	273
SwissProt Accessions	O54910, Q3U686, Q9CZZ9, Q9D7U3	Gene names	Nfkbie, Ikbe
Domain Architecture
Description	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKB-E).

BARD1_MOUSE
NC score	0.785566 (rank : 121)	θ value	6.21693e-09 (rank : 121)
Query Neighborhood Hits	453	Target Neighborhood Hits	411	Shared Neighborhood Hits	282
SwissProt Accessions	O70445	Gene names	Bard1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

AN36B_HUMAN
NC score	0.782785 (rank : 122)	θ value	1.80886e-08 (rank : 131)
Query Neighborhood Hits	453	Target Neighborhood Hits	294	Shared Neighborhood Hits	283
SwissProt Accessions	Q8N2N9, Q6IPR0	Gene names	ANKRD36B
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 36B.

ANR35_HUMAN
NC score	0.778272 (rank : 123)	θ value	1.02475e-11 (rank : 78)
Query Neighborhood Hits	453	Target Neighborhood Hits	784	Shared Neighborhood Hits	294
SwissProt Accessions	Q8N283, Q3MJ10, Q96LS3	Gene names	ANKRD35
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 35.

EHMT2_MOUSE
NC score	0.775859 (rank : 124)	θ value	3.76295e-14 (rank : 55)
Query Neighborhood Hits	453	Target Neighborhood Hits	750	Shared Neighborhood Hits	304
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

ACBD6_MOUSE
NC score	0.775181 (rank : 125)	θ value	1.43324e-05 (rank : 190)
Query Neighborhood Hits	453	Target Neighborhood Hits	305	Shared Neighborhood Hits	288
SwissProt Accessions	Q9D061, Q3TMN7, Q9DCU4	Gene names	Acbd6
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 6.

IKBB_MOUSE
NC score	0.768169 (rank : 126)	θ value	2.21117e-06 (rank : 177)
Query Neighborhood Hits	453	Target Neighborhood Hits	284	Shared Neighborhood Hits	273
SwissProt Accessions	Q60778, Q9D6L5	Gene names	Nfkbib, Ikbb
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B).

IKBB_HUMAN
NC score	0.767818 (rank : 127)	θ value	6.43352e-06 (rank : 182)
Query Neighborhood Hits	453	Target Neighborhood Hits	284	Shared Neighborhood Hits	272
SwissProt Accessions	Q15653, Q96BJ7	Gene names	NFKBIB, IKBB, TRIP9
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9).

ACBD6_HUMAN
NC score	0.767575 (rank : 128)	θ value	3.19293e-05 (rank : 202)
Query Neighborhood Hits	453	Target Neighborhood Hits	304	Shared Neighborhood Hits	285
SwissProt Accessions	Q9BR61	Gene names	ACBD6
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 6.

IKBE_HUMAN
NC score	0.763691 (rank : 129)	θ value	0.0148317 (rank : 315)
Query Neighborhood Hits	453	Target Neighborhood Hits	288	Shared Neighborhood Hits	267
SwissProt Accessions	O00221	Gene names	NFKBIE, IKBE
Domain Architecture
Description	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKBE).

ANFY1_MOUSE
NC score	0.763608 (rank : 130)	θ value	1.42992e-13 (rank : 62)
Query Neighborhood Hits	453	Target Neighborhood Hits	480	Shared Neighborhood Hits	293
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_HUMAN
NC score	0.763471 (rank : 131)	θ value	1.29331e-14 (rank : 52)
Query Neighborhood Hits	453	Target Neighborhood Hits	480	Shared Neighborhood Hits	286
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

POTE8_HUMAN
NC score	0.760808 (rank : 132)	θ value	6.64225e-11 (rank : 86)
Query Neighborhood Hits	453	Target Neighborhood Hits	337	Shared Neighborhood Hits	285
SwissProt Accessions	Q6S8J7, Q6S8J6	Gene names	POTE8
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 8.

RN5A_MOUSE
NC score	0.758250 (rank : 133)	θ value	7.84624e-12 (rank : 77)
Query Neighborhood Hits	453	Target Neighborhood Hits	899	Shared Neighborhood Hits	317
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

USH1G_HUMAN
NC score	0.756529 (rank : 134)	θ value	1.43324e-05 (rank : 196)
Query Neighborhood Hits	453	Target Neighborhood Hits	267	Shared Neighborhood Hits	260
SwissProt Accessions	Q495M9, Q8N251	Gene names	USH1G, SANS
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein (Scaffold protein containing ankyrin repeats and SAM domain).

USH1G_MOUSE
NC score	0.756362 (rank : 135)	θ value	1.43324e-05 (rank : 197)
Query Neighborhood Hits	453	Target Neighborhood Hits	271	Shared Neighborhood Hits	261
SwissProt Accessions	Q80T11, Q80UG0	Gene names	Ush1g, Sans
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein homolog (Scaffold protein containing ankyrin repeats and SAM domain) (Jackson shaker protein).

ANR32_HUMAN
NC score	0.754625 (rank : 136)	θ value	0.00102713 (rank : 260)
Query Neighborhood Hits	453	Target Neighborhood Hits	270	Shared Neighborhood Hits	261
SwissProt Accessions	Q9BQI6	Gene names	ANKRD32
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 32.

ANR41_HUMAN
NC score	0.748829 (rank : 137)	θ value	5.44631e-05 (rank : 217)
Query Neighborhood Hits	453	Target Neighborhood Hits	332	Shared Neighborhood Hits	256
SwissProt Accessions	Q8NAG6, Q8N8J8	Gene names	ANKRD41
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 41.

ANS4B_HUMAN
NC score	0.748646 (rank : 138)	θ value	3.77169e-06 (rank : 180)
Query Neighborhood Hits	453	Target Neighborhood Hits	289	Shared Neighborhood Hits	259
SwissProt Accessions	Q8N8V4	Gene names	ANKS4B, HARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

ANR32_MOUSE
NC score	0.747456 (rank : 139)	θ value	0.00020696 (rank : 234)
Query Neighborhood Hits	453	Target Neighborhood Hits	285	Shared Neighborhood Hits	262
SwissProt Accessions	Q8R3P9, Q5XK30, Q8BHY5, Q921Y9	Gene names	Ankrd32
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 32.

ANR19_HUMAN
NC score	0.746434 (rank : 140)	θ value	8.40245e-06 (rank : 185)
Query Neighborhood Hits	453	Target Neighborhood Hits	276	Shared Neighborhood Hits	271
SwissProt Accessions	Q9H560	Gene names	ANKRD19
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 19.

ZDH17_HUMAN
NC score	0.745417 (rank : 141)	θ value	9.59137e-10 (rank : 109)
Query Neighborhood Hits	453	Target Neighborhood Hits	334	Shared Neighborhood Hits	283
SwissProt Accessions	Q8IUH5, O75407, Q7Z2I0, Q86W89, Q86YK0, Q9P088, Q9UPZ8	Gene names	ZDHHC17, HIP14, HIP3, KIAA0946
Domain Architecture
Description	Palmitoyltransferase ZDHHC17 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 17) (DHHC-17) (Huntingtin-interacting protein 14) (Huntingtin-interacting protein 3) (Huntingtin-interacting protein HYPH) (Putative NF-kappa-B-activating protein 205) (Putative MAPK- activating protein PM11).

CTTB2_HUMAN
NC score	0.741551 (rank : 142)	θ value	9.26847e-13 (rank : 68)
Query Neighborhood Hits	453	Target Neighborhood Hits	1061	Shared Neighborhood Hits	312
SwissProt Accessions	Q8WZ74, O43389, Q7LG11, Q9C0A5	Gene names	CTTNBP2, C7orf8, CORTBP2, KIAA1758
Domain Architecture	No domain graphic available
Description	Cortactin-binding protein 2 (CortBP2).

ZDH17_MOUSE
NC score	0.740783 (rank : 143)	θ value	2.13673e-09 (rank : 115)
Query Neighborhood Hits	453	Target Neighborhood Hits	328	Shared Neighborhood Hits	279
SwissProt Accessions	Q80TN5, Q8BJ08, Q8BYQ2, Q8BYQ6	Gene names	Zdhhc17, Hip14, Kiaa0946
Domain Architecture
Description	Palmitoyltransferase ZDHHC17 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 17) (DHHC-17) (Huntingtin-interacting protein 14).

AN36A_HUMAN
NC score	0.739173 (rank : 144)	θ value	0.00869519 (rank : 307)
Query Neighborhood Hits	453	Target Neighborhood Hits	271	Shared Neighborhood Hits	267
SwissProt Accessions	Q6UX02, Q86X62	Gene names	ANKRD36, ANKRD36A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 36A.

ZDH13_HUMAN
NC score	0.735630 (rank : 145)	θ value	3.29651e-10 (rank : 98)
Query Neighborhood Hits	453	Target Neighborhood Hits	322	Shared Neighborhood Hits	275
SwissProt Accessions	Q8IUH4, Q7Z2D3, Q86VK2, Q9NV30, Q9NV99	Gene names	ZDHHC13, HIP14L, HIP3RP
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC13 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein) (Huntingtin- interacting protein HIP3RP) (Putative NF-kappa-B-activating protein 209) (Putative MAPK-activating protein PM03).

ZDH13_MOUSE
NC score	0.735449 (rank : 146)	θ value	1.133e-10 (rank : 88)
Query Neighborhood Hits	453	Target Neighborhood Hits	329	Shared Neighborhood Hits	278
SwissProt Accessions	Q9CWU2, Q3UK32, Q3UKV1	Gene names	Zdhhc13, Hip14l
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC13 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein).

ANR11_HUMAN
NC score	0.735055 (rank : 147)	θ value	1.25267e-09 (rank : 110)
Query Neighborhood Hits	453	Target Neighborhood Hits	1289	Shared Neighborhood Hits	317
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

ANR15_HUMAN
NC score	0.734356 (rank : 148)	θ value	5.62301e-10 (rank : 104)
Query Neighborhood Hits	453	Target Neighborhood Hits	478	Shared Neighborhood Hits	275
SwissProt Accessions	Q14678, Q5W0W0, Q8IY65, Q8WX74	Gene names	ANKRD15, KANK, KIAA0172
Domain Architecture
Description	Ankyrin repeat domain-containing protein 15 (Kidney ankyrin repeat- containing protein).

ANS4B_MOUSE
NC score	0.734246 (rank : 149)	θ value	0.000121331 (rank : 226)
Query Neighborhood Hits	453	Target Neighborhood Hits	294	Shared Neighborhood Hits	256
SwissProt Accessions	Q8K3X6, Q9D8A5	Gene names	Anks4b, Harp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

ANR37_HUMAN
NC score	0.733180 (rank : 150)	θ value	0.00035302 (rank : 245)
Query Neighborhood Hits	453	Target Neighborhood Hits	247	Shared Neighborhood Hits	246
SwissProt Accessions	Q7Z713	Gene names	ANKRD37, LPR2BP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37 (Low-density lipoprotein receptor-related protein 2-binding protein) (hLrp2bp).

ANR47_MOUSE
NC score	0.731680 (rank : 151)	θ value	1.17247e-07 (rank : 149)
Query Neighborhood Hits	453	Target Neighborhood Hits	350	Shared Neighborhood Hits	265
SwissProt Accessions	Q9Z1P7	Gene names	Ankrd47, D17Ertd288e, Ng28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

ANKY2_HUMAN
NC score	0.730831 (rank : 152)	θ value	0.000121331 (rank : 225)
Query Neighborhood Hits	453	Target Neighborhood Hits	306	Shared Neighborhood Hits	265
SwissProt Accessions	Q8IV38, Q96BL3	Gene names	ANKMY2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and MYND domain-containing protein 2.

SNCAP_HUMAN
NC score	0.724046 (rank : 153)	θ value	8.40245e-06 (rank : 189)
Query Neighborhood Hits	453	Target Neighborhood Hits	313	Shared Neighborhood Hits	239
SwissProt Accessions	Q9Y6H5	Gene names	SNCAIP
Domain Architecture
Description	Synphilin-1 (Alpha-synuclein-interacting protein).

ANR37_MOUSE
NC score	0.719171 (rank : 154)	θ value	1.43324e-05 (rank : 193)
Query Neighborhood Hits	453	Target Neighborhood Hits	237	Shared Neighborhood Hits	237
SwissProt Accessions	Q569N2, Q8CHS0	Gene names	Ankrd37
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37.

NFKB1_HUMAN
NC score	0.716006 (rank : 155)	θ value	2.52405e-10 (rank : 91)
Query Neighborhood Hits	453	Target Neighborhood Hits	306	Shared Neighborhood Hits	274
SwissProt Accessions	P19838, Q68D84, Q86V43, Q8N4X7, Q9NZC0	Gene names	NFKB1
Domain Architecture
Description	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) [Contains: Nuclear factor NF-kappa-B p50 subunit].

NFKB1_MOUSE
NC score	0.715067 (rank : 156)	θ value	6.21693e-09 (rank : 122)
Query Neighborhood Hits	453	Target Neighborhood Hits	300	Shared Neighborhood Hits	267
SwissProt Accessions	P25799, Q3TZE8, Q3V2V6, Q6TDG8, Q75ZL1, Q80Y21, Q8C712	Gene names	Nfkb1
Domain Architecture
Description	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) (NF-kappa-B1 p84/NF-kappa-B1 p98) [Contains: Nuclear factor NF- kappa-B p50 subunit].

POT15_HUMAN
NC score	0.712421 (rank : 157)	θ value	5.62301e-10 (rank : 107)
Query Neighborhood Hits	453	Target Neighborhood Hits	893	Shared Neighborhood Hits	295
SwissProt Accessions	Q6S5H4, Q6NXN7, Q6S5H7	Gene names	POTE15
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 15.

ANR21_HUMAN
NC score	0.711908 (rank : 158)	θ value	1.25267e-09 (rank : 111)
Query Neighborhood Hits	453	Target Neighborhood Hits	864	Shared Neighborhood Hits	295
SwissProt Accessions	Q86YR6	Gene names	ANKRD21, POTE
Domain Architecture
Description	Ankyrin repeat domain-containing protein 21 (Protein POTE) (Prostate, ovary, testis-expressed protein).

SHAN1_HUMAN
NC score	0.710879 (rank : 159)	θ value	6.21693e-09 (rank : 123)
Query Neighborhood Hits	453	Target Neighborhood Hits	1041	Shared Neighborhood Hits	319
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

ANKY2_MOUSE
NC score	0.709795 (rank : 160)	θ value	4.1701e-05 (rank : 209)
Query Neighborhood Hits	453	Target Neighborhood Hits	316	Shared Neighborhood Hits	265
SwissProt Accessions	Q3TPE9, Q8BK14, Q8BYW5, Q8R3N4, Q921J1	Gene names	Ankmy2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and MYND domain-containing protein 2.

ANR12_HUMAN
NC score	0.707451 (rank : 161)	θ value	2.36244e-08 (rank : 133)
Query Neighborhood Hits	453	Target Neighborhood Hits	1081	Shared Neighborhood Hits	302
SwissProt Accessions	Q6UB98, O94951, Q658K1, Q6QMF7, Q9H231, Q9H784	Gene names	ANKRD12, ANCO2, KIAA0874
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein).

NFKB2_HUMAN
NC score	0.705172 (rank : 162)	θ value	6.43352e-06 (rank : 184)
Query Neighborhood Hits	453	Target Neighborhood Hits	325	Shared Neighborhood Hits	278
SwissProt Accessions	Q00653, Q04860, Q9BU75, Q9H471, Q9H472	Gene names	NFKB2, LYT10
Domain Architecture
Description	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10) (Oncogene Lyt-10) (Lyt10) [Contains: Nuclear factor NF-kappa-B p52 subunit].

ANR47_HUMAN
NC score	0.704499 (rank : 163)	θ value	1.69304e-06 (rank : 173)
Query Neighborhood Hits	453	Target Neighborhood Hits	369	Shared Neighborhood Hits	259
SwissProt Accessions	Q6NY19, Q6NZI1, Q6ZQR3, Q8IUV2	Gene names	ANKRD47
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

ASB6_HUMAN
NC score	0.700097 (rank : 164)	θ value	0.125558 (rank : 334)
Query Neighborhood Hits	453	Target Neighborhood Hits	256	Shared Neighborhood Hits	244
SwissProt Accessions	Q9NWX5	Gene names	ASB6
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 6 (ASB-6).

BCOR_MOUSE
NC score	0.699096 (rank : 165)	θ value	1.87187e-05 (rank : 199)
Query Neighborhood Hits	453	Target Neighborhood Hits	521	Shared Neighborhood Hits	286
SwissProt Accessions	Q8CGN4, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3	Gene names	Bcor, Kiaa1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

ASB6_MOUSE
NC score	0.696091 (rank : 166)	θ value	0.0563607 (rank : 326)
Query Neighborhood Hits	453	Target Neighborhood Hits	264	Shared Neighborhood Hits	243
SwissProt Accessions	Q91ZU1, Q8VEC6	Gene names	Asb6
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 6 (ASB-6).

KRIT1_MOUSE
NC score	0.693816 (rank : 167)	θ value	6.43352e-06 (rank : 183)
Query Neighborhood Hits	453	Target Neighborhood Hits	258	Shared Neighborhood Hits	229
SwissProt Accessions	Q6S5J6, Q6VSV2, Q7TPR8, Q8C9Q6, Q9EPY2, Q9ERH0	Gene names	Krit1, Ccm1
Domain Architecture	No domain graphic available
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog).

POT14_HUMAN
NC score	0.691959 (rank : 168)	θ value	9.29e-05 (rank : 223)
Query Neighborhood Hits	453	Target Neighborhood Hits	403	Shared Neighborhood Hits	273
SwissProt Accessions	Q6S5H5, Q6S5H6, Q6S8J2	Gene names	POTE14
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 14.

CD2A1_MOUSE
NC score	0.690198 (rank : 169)	θ value	0.00665767 (rank : 300)
Query Neighborhood Hits	453	Target Neighborhood Hits	206	Shared Neighborhood Hits	202
SwissProt Accessions	P51480, O89088, P97510, P97937, Q6PEA2, Q78E39, Q78E57, Q792X7, Q9QWH6, Q9QWH7, Q9QWH8	Gene names	Cdkn2a, P16ink4a
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 2A, isoforms 1/2 (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4) (p16-INK4a).

BCOR_HUMAN
NC score	0.689971 (rank : 170)	θ value	1.43324e-05 (rank : 194)
Query Neighborhood Hits	453	Target Neighborhood Hits	609	Shared Neighborhood Hits	290
SwissProt Accessions	Q6W2J9, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2	Gene names	BCOR, KIAA1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

NFKB2_MOUSE
NC score	0.689345 (rank : 171)	θ value	1.29631e-06 (rank : 170)
Query Neighborhood Hits	453	Target Neighborhood Hits	326	Shared Neighborhood Hits	274
SwissProt Accessions	Q9WTK5	Gene names	Nfkb2
Domain Architecture
Description	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) [Contains: Nuclear factor NF-kappa-B p52 subunit].

ANR33_MOUSE
NC score	0.681971 (rank : 172)	θ value	1.43324e-05 (rank : 192)
Query Neighborhood Hits	453	Target Neighborhood Hits	225	Shared Neighborhood Hits	222
SwissProt Accessions	Q8BXP5, Q8BXP4, Q8R1Z1	Gene names	Ankrd33
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

KRIT1_HUMAN
NC score	0.681697 (rank : 173)	θ value	8.40245e-06 (rank : 188)
Query Neighborhood Hits	453	Target Neighborhood Hits	258	Shared Neighborhood Hits	222
SwissProt Accessions	O00522, O43894, Q506L6, Q6U276, Q75N19, Q9H180, Q9H264, Q9HAX5	Gene names	KRIT1, CCM1
Domain Architecture
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein).

ANR25_HUMAN
NC score	0.679620 (rank : 174)	θ value	1.43324e-05 (rank : 191)
Query Neighborhood Hits	453	Target Neighborhood Hits	350	Shared Neighborhood Hits	263
SwissProt Accessions	Q63ZY3, Q3KQZ3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210	Gene names	ANKRD25, KIAA1518, SIP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25 (SRC-1-interacting protein) (SRC1-interacting protein).

OSBL1_HUMAN
NC score	0.673248 (rank : 175)	θ value	2.43908e-13 (rank : 64)
Query Neighborhood Hits	453	Target Neighborhood Hits	368	Shared Neighborhood Hits	281
SwissProt Accessions	Q9BXW6, Q9BZF5, Q9NW87	Gene names	OSBPL1A, ORP1, OSBP8, OSBPL1
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

CLPB_MOUSE
NC score	0.667165 (rank : 176)	θ value	0.00228821 (rank : 280)
Query Neighborhood Hits	453	Target Neighborhood Hits	289	Shared Neighborhood Hits	250
SwissProt Accessions	Q60649	Gene names	Clpb, Skd3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

ANR25_MOUSE
NC score	0.666114 (rank : 177)	θ value	8.40245e-06 (rank : 186)
Query Neighborhood Hits	453	Target Neighborhood Hits	398	Shared Neighborhood Hits	263
SwissProt Accessions	Q8BX02, Q8BLD5, Q91Z35	Gene names	Ankrd25
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25.

ANR33_HUMAN
NC score	0.661936 (rank : 178)	θ value	0.00509761 (rank : 294)
Query Neighborhood Hits	453	Target Neighborhood Hits	215	Shared Neighborhood Hits	212
SwissProt Accessions	Q7Z3H0, Q5K619, Q5K621, Q5K622, Q5K623, Q5K624, Q6ZUN0	Gene names	ANKRD33, C12orf7
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

OSBL1_MOUSE
NC score	0.661871 (rank : 179)	θ value	7.09661e-13 (rank : 67)
Query Neighborhood Hits	453	Target Neighborhood Hits	336	Shared Neighborhood Hits	283
SwissProt Accessions	Q91XL9, O88318, Q3TH97, Q673L8, Q6DFU6	Gene names	Osbpl1a, Orp1, Orp1a
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

ANR38_HUMAN
NC score	0.660876 (rank : 180)	θ value	0.000602161 (rank : 253)
Query Neighborhood Hits	453	Target Neighborhood Hits	443	Shared Neighborhood Hits	241
SwissProt Accessions	Q5T7N3, Q6P9A0, Q86T71, Q86VE6, Q8NAX3	Gene names	ANKRD38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

MPP8_HUMAN
NC score	0.651933 (rank : 181)	θ value	0.00035302 (rank : 248)
Query Neighborhood Hits	453	Target Neighborhood Hits	948	Shared Neighborhood Hits	267
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

POT22_HUMAN
NC score	0.650991 (rank : 182)	θ value	0.000786445 (rank : 259)
Query Neighborhood Hits	453	Target Neighborhood Hits	266	Shared Neighborhood Hits	256
SwissProt Accessions	Q6S545	Gene names	ACTBL1, POTE22
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 22.

CDN2B_MOUSE
NC score	0.650911 (rank : 183)	θ value	0.00175202 (rank : 274)
Query Neighborhood Hits	453	Target Neighborhood Hits	201	Shared Neighborhood Hits	199
SwissProt Accessions	P55271	Gene names	Cdkn2b
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b).

OSTF1_MOUSE
NC score	0.650211 (rank : 184)	θ value	3.41135e-07 (rank : 162)
Query Neighborhood Hits	453	Target Neighborhood Hits	467	Shared Neighborhood Hits	265
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

RAI14_HUMAN
NC score	0.639030 (rank : 185)	θ value	1.99529e-15 (rank : 48)
Query Neighborhood Hits	453	Target Neighborhood Hits	1367	Shared Neighborhood Hits	320
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

A20A3_HUMAN
NC score	0.637871 (rank : 186)	θ value	4.1701e-05 (rank : 207)
Query Neighborhood Hits	453	Target Neighborhood Hits	692	Shared Neighborhood Hits	287
SwissProt Accessions	Q5VUR7	Gene names	ANKRD20A3
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A3.

A20A2_HUMAN
NC score	0.636500 (rank : 187)	θ value	0.000121331 (rank : 224)
Query Neighborhood Hits	453	Target Neighborhood Hits	716	Shared Neighborhood Hits	286
SwissProt Accessions	Q4UJ75	Gene names	ANKRD20A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A2.

A20A1_HUMAN
NC score	0.636340 (rank : 188)	θ value	4.1701e-05 (rank : 206)
Query Neighborhood Hits	453	Target Neighborhood Hits	698	Shared Neighborhood Hits	284
SwissProt Accessions	Q5TYW2, Q9H0H6	Gene names	ANKRD20A1, ANKRD20A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A1.

ANR45_MOUSE
NC score	0.635273 (rank : 189)	θ value	0.00035302 (rank : 246)
Query Neighborhood Hits	453	Target Neighborhood Hits	204	Shared Neighborhood Hits	190
SwissProt Accessions	Q810N6	Gene names	Ankrd45
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 45.

ANR38_MOUSE
NC score	0.633820 (rank : 190)	θ value	0.00020696 (rank : 235)
Query Neighborhood Hits	453	Target Neighborhood Hits	512	Shared Neighborhood Hits	243
SwissProt Accessions	Q6P9J5, Q8BV03	Gene names	Ankrd38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

A20A4_HUMAN
NC score	0.633281 (rank : 191)	θ value	4.1701e-05 (rank : 208)
Query Neighborhood Hits	453	Target Neighborhood Hits	710	Shared Neighborhood Hits	287
SwissProt Accessions	Q5SQ80	Gene names	ANKRD20A4
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A4.

OSTF1_HUMAN
NC score	0.631640 (rank : 192)	θ value	1.29631e-06 (rank : 171)
Query Neighborhood Hits	453	Target Neighborhood Hits	466	Shared Neighborhood Hits	263
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

CD2A1_HUMAN
NC score	0.619571 (rank : 193)	θ value	0.00102713 (rank : 263)
Query Neighborhood Hits	453	Target Neighborhood Hits	196	Shared Neighborhood Hits	194
SwissProt Accessions	P42771, O95440, Q15191, Q5VVJ5, Q96B52, Q9NP05	Gene names	CDKN2A, CDKN2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4) (p16-INK4a) (p16INK4A) (Multiple tumor suppressor 1) (MTS1).

ANR43_MOUSE
NC score	0.603263 (rank : 194)	θ value	0.00175202 (rank : 273)
Query Neighborhood Hits	453	Target Neighborhood Hits	214	Shared Neighborhood Hits	205
SwissProt Accessions	Q8BLS7	Gene names	Ankrd43
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 43.

RAI14_MOUSE
NC score	0.601432 (rank : 195)	θ value	1.68911e-14 (rank : 54)
Query Neighborhood Hits	453	Target Neighborhood Hits	1505	Shared Neighborhood Hits	311
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

ANR43_HUMAN
NC score	0.600849 (rank : 196)	θ value	0.0563607 (rank : 325)
Query Neighborhood Hits	453	Target Neighborhood Hits	209	Shared Neighborhood Hits	202
SwissProt Accessions	Q2M3V2, Q8NAE7	Gene names	ANKRD43
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 43.

ANR45_HUMAN
NC score	0.600729 (rank : 197)	θ value	4.1701e-05 (rank : 211)
Query Neighborhood Hits	453	Target Neighborhood Hits	201	Shared Neighborhood Hits	185
SwissProt Accessions	Q5TZF3, Q6ZST1	Gene names	ANKRD45
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 45.

ANR18_HUMAN
NC score	0.597757 (rank : 198)	θ value	2.61198e-07 (rank : 156)
Query Neighborhood Hits	453	Target Neighborhood Hits	1106	Shared Neighborhood Hits	288
SwissProt Accessions	Q8IVF6, Q7Z468	Gene names	ANKRD18A, KIAA2015
Domain Architecture
Description	Ankyrin repeat domain-containing protein 18A.

CDN2B_HUMAN
NC score	0.593957 (rank : 199)	θ value	1.38821 (rank : 371)
Query Neighborhood Hits	453	Target Neighborhood Hits	196	Shared Neighborhood Hits	195
SwissProt Accessions	P42772, Q6FI09	Gene names	CDKN2B, MTS2
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b) (p15INK4B) (Multiple tumor suppressor 2) (MTS2).

CLPB_HUMAN
NC score	0.590483 (rank : 200)	θ value	0.000158464 (rank : 230)
Query Neighborhood Hits	453	Target Neighborhood Hits	265	Shared Neighborhood Hits	238
SwissProt Accessions	Q9H078, Q8ND11, Q9H8Y0	Gene names	CLPB, SKD3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

HECD1_HUMAN
NC score	0.588914 (rank : 201)	θ value	0.000270298 (rank : 244)
Query Neighborhood Hits	453	Target Neighborhood Hits	371	Shared Neighborhood Hits	270
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

ANKK1_HUMAN
NC score	0.585931 (rank : 202)	θ value	8.08199e-25 (rank : 14)
Query Neighborhood Hits	453	Target Neighborhood Hits	1075	Shared Neighborhood Hits	322
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

ANR40_HUMAN
NC score	0.582497 (rank : 203)	θ value	0.00869519 (rank : 308)
Query Neighborhood Hits	453	Target Neighborhood Hits	224	Shared Neighborhood Hits	204
SwissProt Accessions	Q6AI12, Q96E32	Gene names	ANKRD40
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 40.

NUD12_MOUSE
NC score	0.581889 (rank : 204)	θ value	5.44631e-05 (rank : 220)
Query Neighborhood Hits	453	Target Neighborhood Hits	243	Shared Neighborhood Hits	223
SwissProt Accessions	Q9DCN1, Q6PFA5	Gene names	Nudt12
Domain Architecture	No domain graphic available
Description	Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12).

RIPK4_HUMAN
NC score	0.581843 (rank : 205)	θ value	4.28545e-26 (rank : 11)
Query Neighborhood Hits	453	Target Neighborhood Hits	1094	Shared Neighborhood Hits	328
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

ANR40_MOUSE
NC score	0.578701 (rank : 206)	θ value	0.00869519 (rank : 309)
Query Neighborhood Hits	453	Target Neighborhood Hits	228	Shared Neighborhood Hits	208
SwissProt Accessions	Q5SUE8, Q8R595, Q9CU71	Gene names	Ankrd40
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 40.

ABTB2_HUMAN
NC score	0.571344 (rank : 207)	θ value	0.00869519 (rank : 306)
Query Neighborhood Hits	453	Target Neighborhood Hits	391	Shared Neighborhood Hits	240
SwissProt Accessions	Q8N961, Q6MZW4, Q8NB44	Gene names	ABTB2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

ANKK1_MOUSE
NC score	0.570867 (rank : 208)	θ value	1.5242e-23 (rank : 15)
Query Neighborhood Hits	453	Target Neighborhood Hits	1072	Shared Neighborhood Hits	321
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

ANKY1_HUMAN
NC score	0.566648 (rank : 209)	θ value	0.00020696 (rank : 233)
Query Neighborhood Hits	453	Target Neighborhood Hits	248	Shared Neighborhood Hits	203
SwissProt Accessions	Q9P2S6, Q8IYX5, Q8NDK5, Q9NX10	Gene names	ANKMY1, TSAL1, ZMYND13
Domain Architecture
Description	Ankyrin repeat and MYND domain-containing protein 1 (Testis-specific ankyrin-like protein 1) (Zinc-finger MYND domain-containing protein 13).

AN30A_HUMAN
NC score	0.565994 (rank : 210)	θ value	2.88788e-06 (rank : 179)
Query Neighborhood Hits	453	Target Neighborhood Hits	1119	Shared Neighborhood Hits	287
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

ABTB2_MOUSE
NC score	0.560454 (rank : 211)	θ value	0.00390308 (rank : 289)
Query Neighborhood Hits	453	Target Neighborhood Hits	414	Shared Neighborhood Hits	241
SwissProt Accessions	Q7TQI7	Gene names	Abtb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

ASPP2_HUMAN
NC score	0.554051 (rank : 212)	θ value	5.44631e-05 (rank : 219)
Query Neighborhood Hits	453	Target Neighborhood Hits	1156	Shared Neighborhood Hits	291
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

NUD12_HUMAN
NC score	0.550572 (rank : 213)	θ value	0.00134147 (rank : 272)
Query Neighborhood Hits	453	Target Neighborhood Hits	222	Shared Neighborhood Hits	203
SwissProt Accessions	Q9BQG2, Q8TAL7	Gene names	NUDT12
Domain Architecture	No domain graphic available
Description	Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12).

TRPV6_MOUSE
NC score	0.544195 (rank : 214)	θ value	3.19293e-05 (rank : 205)
Query Neighborhood Hits	453	Target Neighborhood Hits	284	Shared Neighborhood Hits	253
SwissProt Accessions	Q91WD2	Gene names	Trpv6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1).

GLSL_HUMAN
NC score	0.543997 (rank : 215)	θ value	8.40245e-06 (rank : 187)
Query Neighborhood Hits	453	Target Neighborhood Hits	211	Shared Neighborhood Hits	203
SwissProt Accessions	Q9UI32, Q9NYY2, Q9UI31	Gene names	GLS2, GA
Domain Architecture
Description	Glutaminase liver isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (L-glutaminase).

ILK2_HUMAN
NC score	0.543695 (rank : 216)	θ value	1.17247e-07 (rank : 152)
Query Neighborhood Hits	453	Target Neighborhood Hits	848	Shared Neighborhood Hits	311
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

GLSL_MOUSE
NC score	0.541289 (rank : 217)	θ value	1.99992e-07 (rank : 155)
Query Neighborhood Hits	453	Target Neighborhood Hits	212	Shared Neighborhood Hits	204
SwissProt Accessions	Q571F8	Gene names	Gls2, Kiaa4146
Domain Architecture	No domain graphic available
Description	Glutaminase liver isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (L-glutaminase).

ASPP1_HUMAN
NC score	0.539802 (rank : 218)	θ value	0.000121331 (rank : 227)
Query Neighborhood Hits	453	Target Neighborhood Hits	956	Shared Neighborhood Hits	289
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

IASPP_HUMAN
NC score	0.539519 (rank : 219)	θ value	0.00298849 (rank : 287)
Query Neighborhood Hits	453	Target Neighborhood Hits	688	Shared Neighborhood Hits	270
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ASB14_HUMAN
NC score	0.535466 (rank : 220)	θ value	1.38821 (rank : 370)
Query Neighborhood Hits	453	Target Neighborhood Hits	187	Shared Neighborhood Hits	175
SwissProt Accessions	Q8WXK2	Gene names	ASB14
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 14 (ASB-14).

ILK1_HUMAN
NC score	0.526766 (rank : 221)	θ value	1.17247e-07 (rank : 151)
Query Neighborhood Hits	453	Target Neighborhood Hits	857	Shared Neighborhood Hits	311
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

CENB5_HUMAN
NC score	0.525614 (rank : 222)	θ value	0.00035302 (rank : 247)
Query Neighborhood Hits	453	Target Neighborhood Hits	395	Shared Neighborhood Hits	265
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

ILK_MOUSE
NC score	0.525590 (rank : 223)	θ value	5.26297e-08 (rank : 141)
Query Neighborhood Hits	453	Target Neighborhood Hits	858	Shared Neighborhood Hits	311
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ASPP1_MOUSE
NC score	0.521694 (rank : 224)	θ value	0.000121331 (rank : 228)
Query Neighborhood Hits	453	Target Neighborhood Hits	1244	Shared Neighborhood Hits	292
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

CENB1_HUMAN
NC score	0.521548 (rank : 225)	θ value	1.87187e-05 (rank : 200)
Query Neighborhood Hits	453	Target Neighborhood Hits	383	Shared Neighborhood Hits	260
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

AN13C_HUMAN
NC score	0.519524 (rank : 226)	θ value	0.000602161 (rank : 252)
Query Neighborhood Hits	453	Target Neighborhood Hits	241	Shared Neighborhood Hits	234
SwissProt Accessions	Q8N6S4, Q5VYH4, Q5VYH5, Q6PJE4, Q9H0N9	Gene names	ANKRD13C
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13C.

CENB2_HUMAN
NC score	0.516674 (rank : 227)	θ value	0.00020696 (rank : 236)
Query Neighborhood Hits	453	Target Neighborhood Hits	425	Shared Neighborhood Hits	258
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

AN13B_HUMAN
NC score	0.513814 (rank : 228)	θ value	0.279714 (rank : 340)
Query Neighborhood Hits	453	Target Neighborhood Hits	265	Shared Neighborhood Hits	251
SwissProt Accessions	Q86YJ7, Q8N7S9	Gene names	ANKRD13B
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13B.

AN13B_MOUSE
NC score	0.513812 (rank : 229)	θ value	0.279714 (rank : 341)
Query Neighborhood Hits	453	Target Neighborhood Hits	276	Shared Neighborhood Hits	250
SwissProt Accessions	Q5F259, Q6IR40	Gene names	Ankrd13b
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13B.

AN13C_MOUSE
NC score	0.504791 (rank : 230)	θ value	0.0148317 (rank : 314)
Query Neighborhood Hits	453	Target Neighborhood Hits	242	Shared Neighborhood Hits	232
SwissProt Accessions	Q3UX43, Q6P1G4	Gene names	Ankrd13c
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13C.

GLSK_HUMAN
NC score	0.498811 (rank : 231)	θ value	0.000270298 (rank : 243)
Query Neighborhood Hits	453	Target Neighborhood Hits	204	Shared Neighborhood Hits	190
SwissProt Accessions	O94925, Q9UL05, Q9UL06, Q9UL07, Q9UN40	Gene names	GLS, GLS1, KIAA0838
Domain Architecture
Description	Glutaminase kidney isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (K-glutaminase).

UACA_HUMAN
NC score	0.492533 (rank : 232)	θ value	4.0297e-08 (rank : 138)
Query Neighborhood Hits	453	Target Neighborhood Hits	1622	Shared Neighborhood Hits	312
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

TRPV5_MOUSE
NC score	0.491434 (rank : 233)	θ value	0.0431538 (rank : 324)
Query Neighborhood Hits	453	Target Neighborhood Hits	278	Shared Neighborhood Hits	246
SwissProt Accessions	P69744	Gene names	Trpv5
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC1) (Calcium transport protein 2) (CaT2).

IASPP_MOUSE
NC score	0.487522 (rank : 234)	θ value	0.00228821 (rank : 283)
Query Neighborhood Hits	453	Target Neighborhood Hits	1024	Shared Neighborhood Hits	274
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

CT012_MOUSE
NC score	0.476371 (rank : 235)	θ value	0.00102713 (rank : 264)
Query Neighborhood Hits	453	Target Neighborhood Hits	229	Shared Neighborhood Hits	182
SwissProt Accessions	Q8C008, Q8C060	Gene names
Domain Architecture	No domain graphic available
Description	Protein C20orf12 homolog.

GIT2_MOUSE
NC score	0.472405 (rank : 236)	θ value	1.06291 (rank : 364)
Query Neighborhood Hits	453	Target Neighborhood Hits	323	Shared Neighborhood Hits	253
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

TNI3K_HUMAN
NC score	0.470305 (rank : 237)	θ value	1.86321e-21 (rank : 25)
Query Neighborhood Hits	453	Target Neighborhood Hits	1084	Shared Neighborhood Hits	321
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

UACA_MOUSE
NC score	0.466665 (rank : 238)	θ value	4.45536e-07 (rank : 165)
Query Neighborhood Hits	453	Target Neighborhood Hits	1620	Shared Neighborhood Hits	307
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

TNI3K_MOUSE
NC score	0.465502 (rank : 239)	θ value	1.5773e-20 (rank : 26)
Query Neighborhood Hits	453	Target Neighborhood Hits	1079	Shared Neighborhood Hits	321
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

AN13A_HUMAN
NC score	0.465005 (rank : 240)	θ value	0.000461057 (rank : 250)
Query Neighborhood Hits	453	Target Neighborhood Hits	243	Shared Neighborhood Hits	225
SwissProt Accessions	Q8IZ07, O60736	Gene names	ANKRD13A, ANKRD13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13A (Protein KE03).

TRPV6_HUMAN
NC score	0.460990 (rank : 241)	θ value	0.00509761 (rank : 299)
Query Neighborhood Hits	453	Target Neighborhood Hits	262	Shared Neighborhood Hits	226
SwissProt Accessions	Q9H1D0, Q8TDL3, Q8WXR8, Q96LC5, Q9H1D1, Q9H296	Gene names	TRPV6, ECAC2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1) (CaT-like) (CaT-L).

TRPV5_HUMAN
NC score	0.457219 (rank : 242)	θ value	0.00102713 (rank : 270)
Query Neighborhood Hits	453	Target Neighborhood Hits	261	Shared Neighborhood Hits	224
SwissProt Accessions	Q9NQA5, Q8NDW5, Q8NDX7, Q8NDX8, Q96PM6	Gene names	TRPV5, ECAC1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Calcium transport protein 2) (CaT2).

GIT1_MOUSE
NC score	0.457175 (rank : 243)	θ value	0.365318 (rank : 345)
Query Neighborhood Hits	453	Target Neighborhood Hits	341	Shared Neighborhood Hits	250
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

DDFL1_MOUSE
NC score	0.456111 (rank : 244)	θ value	0.000270298 (rank : 241)
Query Neighborhood Hits	453	Target Neighborhood Hits	324	Shared Neighborhood Hits	254
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

NOTC4_MOUSE
NC score	0.455833 (rank : 245)	θ value	9.59137e-10 (rank : 108)
Query Neighborhood Hits	453	Target Neighborhood Hits	872	Shared Neighborhood Hits	298
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

GIT1_HUMAN
NC score	0.455609 (rank : 246)	θ value	0.365318 (rank : 344)
Query Neighborhood Hits	453	Target Neighborhood Hits	336	Shared Neighborhood Hits	248
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

NOTC4_HUMAN
NC score	0.450029 (rank : 247)	θ value	1.25267e-09 (rank : 112)
Query Neighborhood Hits	453	Target Neighborhood Hits	905	Shared Neighborhood Hits	298
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

ANR26_MOUSE
NC score	0.445175 (rank : 248)	θ value	1.87187e-05 (rank : 198)
Query Neighborhood Hits	453	Target Neighborhood Hits	1554	Shared Neighborhood Hits	306
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

GIT2_HUMAN
NC score	0.436017 (rank : 249)	θ value	1.81305 (rank : 380)
Query Neighborhood Hits	453	Target Neighborhood Hits	381	Shared Neighborhood Hits	247
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

AN13A_MOUSE
NC score	0.433808 (rank : 250)	θ value	0.00509761 (rank : 293)
Query Neighborhood Hits	453	Target Neighborhood Hits	226	Shared Neighborhood Hits	216
SwissProt Accessions	Q80UP5, Q2VPQ7, Q6P7F2	Gene names	Ankrd13a, Ankrd13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13A.

CT012_HUMAN
NC score	0.433207 (rank : 251)	θ value	0.0113563 (rank : 312)
Query Neighborhood Hits	453	Target Neighborhood Hits	205	Shared Neighborhood Hits	167
SwissProt Accessions	Q9NVP4, Q4F7X1, Q5QPD9, Q5QPE0, Q68DN8, Q6ZMX9, Q96NF0, Q9H1E0, Q9H442	Gene names	C20orf12
Domain Architecture
Description	Protein C20orf12.

ANR26_HUMAN
NC score	0.425928 (rank : 252)	θ value	4.1701e-05 (rank : 210)
Query Neighborhood Hits	453	Target Neighborhood Hits	1614	Shared Neighborhood Hits	314
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

TEX14_HUMAN
NC score	0.416474 (rank : 253)	θ value	1.43324e-05 (rank : 195)
Query Neighborhood Hits	453	Target Neighborhood Hits	1103	Shared Neighborhood Hits	279
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
NC score	0.415431 (rank : 254)	θ value	5.44631e-05 (rank : 221)
Query Neighborhood Hits	453	Target Neighborhood Hits	1333	Shared Neighborhood Hits	292
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

NOTC3_MOUSE
NC score	0.413184 (rank : 255)	θ value	4.30538e-10 (rank : 103)
Query Neighborhood Hits	453	Target Neighborhood Hits	975	Shared Neighborhood Hits	304
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

DAPK1_MOUSE
NC score	0.411582 (rank : 256)	θ value	3.88503e-19 (rank : 29)
Query Neighborhood Hits	453	Target Neighborhood Hits	1138	Shared Neighborhood Hits	323
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

NOTC3_HUMAN
NC score	0.411433 (rank : 257)	θ value	2.52405e-10 (rank : 93)
Query Neighborhood Hits	453	Target Neighborhood Hits	1062	Shared Neighborhood Hits	304
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

NOTC1_HUMAN
NC score	0.410539 (rank : 258)	θ value	2.69671e-12 (rank : 69)
Query Neighborhood Hits	453	Target Neighborhood Hits	906	Shared Neighborhood Hits	290
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

NOTC2_HUMAN
NC score	0.405870 (rank : 259)	θ value	6.87365e-08 (rank : 143)
Query Neighborhood Hits	453	Target Neighborhood Hits	1113	Shared Neighborhood Hits	297
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

NOTC2_MOUSE
NC score	0.404231 (rank : 260)	θ value	6.87365e-08 (rank : 144)
Query Neighborhood Hits	453	Target Neighborhood Hits	1069	Shared Neighborhood Hits	298
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

DAPK1_HUMAN
NC score	0.404024 (rank : 261)	θ value	2.69047e-20 (rank : 27)
Query Neighborhood Hits	453	Target Neighborhood Hits	1130	Shared Neighborhood Hits	320
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DDEF2_HUMAN
NC score	0.372795 (rank : 262)	θ value	0.0252991 (rank : 319)
Query Neighborhood Hits	453	Target Neighborhood Hits	599	Shared Neighborhood Hits	242
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
NC score	0.366755 (rank : 263)	θ value	1.81305 (rank : 377)
Query Neighborhood Hits	453	Target Neighborhood Hits	625	Shared Neighborhood Hits	241
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DGKZ_HUMAN
NC score	0.358978 (rank : 264)	θ value	0.163984 (rank : 336)
Query Neighborhood Hits	453	Target Neighborhood Hits	551	Shared Neighborhood Hits	220
SwissProt Accessions	Q13574, O00542	Gene names	DGKZ, DAGK6
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

DDFL1_HUMAN
NC score	0.355311 (rank : 265)	θ value	0.813845 (rank : 353)
Query Neighborhood Hits	453	Target Neighborhood Hits	353	Shared Neighborhood Hits	233
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

ANKZ1_MOUSE
NC score	0.352554 (rank : 266)	θ value	0.0736092 (rank : 328)
Query Neighborhood Hits	453	Target Neighborhood Hits	208	Shared Neighborhood Hits	154
SwissProt Accessions	Q80UU1, Q9CZF5	Gene names	Ankzf1, D1Ertd161e
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1.

NOTC1_MOUSE
NC score	0.350371 (rank : 267)	θ value	2.52405e-10 (rank : 92)
Query Neighborhood Hits	453	Target Neighborhood Hits	916	Shared Neighborhood Hits	266
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

ANKZ1_HUMAN
NC score	0.341016 (rank : 268)	θ value	0.0961366 (rank : 331)
Query Neighborhood Hits	453	Target Neighborhood Hits	236	Shared Neighborhood Hits	159
SwissProt Accessions	Q9H8Y5, Q9NVZ4	Gene names	ANKZF1, ZNF744
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1 (Zinc finger protein 744).

DGKI_HUMAN
NC score	0.339643 (rank : 269)	θ value	0.0252991 (rank : 320)
Query Neighborhood Hits	453	Target Neighborhood Hits	609	Shared Neighborhood Hits	221
SwissProt Accessions	O75912, Q9NZ49	Gene names	DGKI
Domain Architecture
Description	Diacylglycerol kinase iota (EC 2.7.1.107) (Diglyceride kinase iota) (DGK-iota) (DAG kinase iota).

DGKZ_MOUSE
NC score	0.337924 (rank : 270)	θ value	4.03905 (rank : 401)
Query Neighborhood Hits	453	Target Neighborhood Hits	542	Shared Neighborhood Hits	205
SwissProt Accessions	Q80UP3	Gene names	Dgkz
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

CENG2_HUMAN
NC score	0.320926 (rank : 271)	θ value	0.813845 (rank : 351)
Query Neighborhood Hits	453	Target Neighborhood Hits	471	Shared Neighborhood Hits	255
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

CENG1_MOUSE
NC score	0.320635 (rank : 272)	θ value	1.38821 (rank : 372)
Query Neighborhood Hits	453	Target Neighborhood Hits	531	Shared Neighborhood Hits	246
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

CENG1_HUMAN
NC score	0.318560 (rank : 273)	θ value	2.36792 (rank : 385)
Query Neighborhood Hits	453	Target Neighborhood Hits	544	Shared Neighborhood Hits	247
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

CENG2_MOUSE
NC score	0.318245 (rank : 274)	θ value	0.813845 (rank : 352)
Query Neighborhood Hits	453	Target Neighborhood Hits	463	Shared Neighborhood Hits	252
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

IKBL_HUMAN
NC score	0.317301 (rank : 275)	θ value	5.27518 (rank : 414)
Query Neighborhood Hits	453	Target Neighborhood Hits	168	Shared Neighborhood Hits	139
SwissProt Accessions	Q9UBC1, Q14625, Q9UBX4	Gene names	NFKBIL1, IKBL
Domain Architecture
Description	NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like) (I- kappa-B-like) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1).

IKBL_MOUSE
NC score	0.309954 (rank : 276)	θ value	5.27518 (rank : 415)
Query Neighborhood Hits	453	Target Neighborhood Hits	196	Shared Neighborhood Hits	139
SwissProt Accessions	O88995, Q91X16, Q9R1Y3	Gene names	Nfkbil1, Ikbl
Domain Architecture
Description	NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like) (I- kappa-B-like) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1).

CENG3_MOUSE
NC score	0.291176 (rank : 277)	θ value	1.06291 (rank : 362)
Query Neighborhood Hits	453	Target Neighborhood Hits	467	Shared Neighborhood Hits	229
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_HUMAN
NC score	0.290793 (rank : 278)	θ value	1.06291 (rank : 361)
Query Neighborhood Hits	453	Target Neighborhood Hits	455	Shared Neighborhood Hits	228
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

DDEF1_MOUSE
NC score	0.290686 (rank : 279)	θ value	0.00509761 (rank : 297)
Query Neighborhood Hits	453	Target Neighborhood Hits	592	Shared Neighborhood Hits	202
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

ABTB1_MOUSE
NC score	0.289484 (rank : 280)	θ value	1.06291 (rank : 360)
Query Neighborhood Hits	453	Target Neighborhood Hits	349	Shared Neighborhood Hits	177
SwissProt Accessions	Q99LJ2, Q8C2K7, Q91XU4	Gene names	Abtb1, Bpoz
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 1.

CLR59_HUMAN
NC score	0.287980 (rank : 281)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	453	Target Neighborhood Hits	163	Shared Neighborhood Hits	138
SwissProt Accessions	Q96DZ5, Q8WWL1, Q96C99, Q9UFT7	Gene names	CLIPR59
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 170-related 59 kDa protein (CLIPR-59) (CLIP-170-related 59 kDa protein).

BAT4_MOUSE
NC score	0.266116 (rank : 282)	θ value	6.88961 (rank : 421)
Query Neighborhood Hits	453	Target Neighborhood Hits	171	Shared Neighborhood Hits	121
SwissProt Accessions	Q61858, Q9R065	Gene names	Bat4, Bat-4, G5
Domain Architecture
Description	Protein BAT4 (HLA-B-associated transcript 4) (G5 protein).

ANKR9_MOUSE
NC score	0.257650 (rank : 283)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	453	Target Neighborhood Hits	120	Shared Neighborhood Hits	114
SwissProt Accessions	Q8BH83, Q3TA09, Q8BHR3	Gene names	Ankrd9
Domain Architecture
Description	Ankyrin repeat domain-containing protein 9.

RSNL2_HUMAN
NC score	0.251980 (rank : 284)	θ value	0.0330416 (rank : 321)
Query Neighborhood Hits	453	Target Neighborhood Hits	136	Shared Neighborhood Hits	113
SwissProt Accessions	Q8N3C7, Q7Z4U3, Q96BR7, Q96MA5, Q9H7C0	Gene names	RSNL2
Domain Architecture	No domain graphic available
Description	Restin-like protein 2.

ABTB1_HUMAN
NC score	0.247849 (rank : 285)	θ value	2.36792 (rank : 384)
Query Neighborhood Hits	453	Target Neighborhood Hits	325	Shared Neighborhood Hits	162
SwissProt Accessions	Q969K4, Q6ZNU9, Q71MF1, Q96S62, Q96S63	Gene names	ABTB1, BPOZ
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 1 (Elongation factor 1A-binding protein).

TRPV3_MOUSE
NC score	0.236034 (rank : 286)	θ value	0.47712 (rank : 347)
Query Neighborhood Hits	453	Target Neighborhood Hits	188	Shared Neighborhood Hits	132
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

BAT4_HUMAN
NC score	0.236026 (rank : 287)	θ value	6.88961 (rank : 420)
Query Neighborhood Hits	453	Target Neighborhood Hits	157	Shared Neighborhood Hits	110
SwissProt Accessions	O95872	Gene names	BAT4, G5
Domain Architecture
Description	Protein BAT4 (HLA-B-associated transcript 4) (G5 protein).

TRPV3_HUMAN
NC score	0.231211 (rank : 288)	θ value	5.27518 (rank : 419)
Query Neighborhood Hits	453	Target Neighborhood Hits	198	Shared Neighborhood Hits	142
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

TRPV1_MOUSE
NC score	0.230568 (rank : 289)	θ value	1.06291 (rank : 369)
Query Neighborhood Hits	453	Target Neighborhood Hits	189	Shared Neighborhood Hits	155
SwissProt Accessions	Q704Y3, Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0	Gene names	Trpv1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).

TRPV1_HUMAN
NC score	0.211474 (rank : 290)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	453	Target Neighborhood Hits	184	Shared Neighborhood Hits	147
SwissProt Accessions	Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22	Gene names	TRPV1, VR1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Capsaicin receptor).

ANKR9_HUMAN
NC score	0.209971 (rank : 291)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	453	Target Neighborhood Hits	99	Shared Neighborhood Hits	95
SwissProt Accessions	Q96BM1	Gene names	ANKRD9
Domain Architecture
Description	Ankyrin repeat domain-containing protein 9.

RSNL2_MOUSE
NC score	0.202901 (rank : 292)	θ value	5.27518 (rank : 417)
Query Neighborhood Hits	453	Target Neighborhood Hits	129	Shared Neighborhood Hits	95
SwissProt Accessions	Q8CI96, Q8BW09, Q921Q4, Q9D2S6	Gene names	Rsnl2
Domain Architecture	No domain graphic available
Description	Restin-like protein 2.

TRPV2_HUMAN
NC score	0.196683 (rank : 293)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	453	Target Neighborhood Hits	130	Shared Neighborhood Hits	109
SwissProt Accessions	Q9Y5S1, Q9Y670	Gene names	TRPV2, VRL
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1).

ARH_HUMAN
NC score	0.187416 (rank : 294)	θ value	7.59969e-07 (rank : 167)
Query Neighborhood Hits	453	Target Neighborhood Hits	38	Shared Neighborhood Hits	24
SwissProt Accessions	Q5SW96, Q6TQS9, Q8N2Y0, Q9UFI9	Gene names	LDLRAP1, ARH
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein).

ARH_MOUSE
NC score	0.186026 (rank : 295)	θ value	1.17247e-07 (rank : 150)
Query Neighborhood Hits	453	Target Neighborhood Hits	32	Shared Neighborhood Hits	20
SwissProt Accessions	Q8C142, Q6NWV6, Q8VDQ0	Gene names	Ldlrap1, Arh
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein homolog).

CMTA1_HUMAN
NC score	0.184472 (rank : 296)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	453	Target Neighborhood Hits	217	Shared Neighborhood Hits	104
SwissProt Accessions	Q9Y6Y1, Q5VUE1	Gene names	CAMTA1, KIAA0833
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 1.

NUMB_MOUSE
NC score	0.167787 (rank : 297)	θ value	3.41135e-07 (rank : 161)
Query Neighborhood Hits	453	Target Neighborhood Hits	91	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QZS3, P70422, Q8CIB1, Q9DC57, Q9QZR1, Q9QZS4	Gene names	Numb
Domain Architecture
Description	Protein numb homolog (m-Numb) (m-Nb).

CAPON_MOUSE
NC score	0.166492 (rank : 298)	θ value	2.61198e-07 (rank : 157)
Query Neighborhood Hits	453	Target Neighborhood Hits	34	Shared Neighborhood Hits	16
SwissProt Accessions	Q9D3A8, Q80TZ6	Gene names	Nos1ap, Capon, Kiaa0464
Domain Architecture	No domain graphic available
Description	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein).

CAPON_HUMAN
NC score	0.166153 (rank : 299)	θ value	9.92553e-07 (rank : 169)
Query Neighborhood Hits	453	Target Neighborhood Hits	35	Shared Neighborhood Hits	15
SwissProt Accessions	O75052, O43564	Gene names	NOS1AP, CAPON, KIAA0464
Domain Architecture	No domain graphic available
Description	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein).

NUMBL_MOUSE
NC score	0.165805 (rank : 300)	θ value	6.87365e-08 (rank : 145)
Query Neighborhood Hits	453	Target Neighborhood Hits	147	Shared Neighborhood Hits	24
SwissProt Accessions	O08919, Q6NVG8	Gene names	Numbl, Nbl
Domain Architecture
Description	Numb-like protein.

NUMB_HUMAN
NC score	0.165522 (rank : 301)	θ value	3.41135e-07 (rank : 160)
Query Neighborhood Hits	453	Target Neighborhood Hits	112	Shared Neighborhood Hits	27
SwissProt Accessions	P49757, Q6NUQ7, Q86SY1, Q8WW73, Q9UBG1, Q9UEQ4, Q9UKE8, Q9UKE9, Q9UKF0, Q9UQJ4	Gene names	NUMB
Domain Architecture
Description	Protein numb homolog (h-Numb) (Protein S171).

SAMN1_MOUSE
NC score	0.152816 (rank : 302)	θ value	2.21117e-06 (rank : 178)
Query Neighborhood Hits	453	Target Neighborhood Hits	69	Shared Neighborhood Hits	17
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

CMTA2_HUMAN
NC score	0.151438 (rank : 303)	θ value	8.99809 (rank : 439)
Query Neighborhood Hits	453	Target Neighborhood Hits	199	Shared Neighborhood Hits	90
SwissProt Accessions	O94983, Q7Z6M8, Q8N3V0, Q8NDG4, Q96G17	Gene names	CAMTA2, KIAA0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

SASH1_MOUSE
NC score	0.150638 (rank : 304)	θ value	0.00020696 (rank : 239)
Query Neighborhood Hits	453	Target Neighborhood Hits	263	Shared Neighborhood Hits	51
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

TRPV2_MOUSE
NC score	0.150583 (rank : 305)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	453	Target Neighborhood Hits	111	Shared Neighborhood Hits	89
SwissProt Accessions	Q9WTR1, Q99K71	Gene names	Trpv2, Grc
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Growth factor-regulated calcium channel) (GRC).

TRPC6_HUMAN
NC score	0.149770 (rank : 306)	θ value	0.00175202 (rank : 279)
Query Neighborhood Hits	453	Target Neighborhood Hits	171	Shared Neighborhood Hits	104
SwissProt Accessions	Q9Y210, Q9HCW3, Q9NQA8, Q9NQA9	Gene names	TRPC6, TRP6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6).

SASH1_HUMAN
NC score	0.149689 (rank : 307)	θ value	0.00035302 (rank : 249)
Query Neighborhood Hits	453	Target Neighborhood Hits	292	Shared Neighborhood Hits	61
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SLY_MOUSE
NC score	0.149412 (rank : 308)	θ value	1.69304e-06 (rank : 175)
Query Neighborhood Hits	453	Target Neighborhood Hits	108	Shared Neighborhood Hits	21
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SLY_HUMAN
NC score	0.148653 (rank : 309)	θ value	1.69304e-06 (rank : 174)
Query Neighborhood Hits	453	Target Neighborhood Hits	81	Shared Neighborhood Hits	17
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

NUMBL_HUMAN
NC score	0.147647 (rank : 310)	θ value	4.45536e-07 (rank : 164)
Query Neighborhood Hits	453	Target Neighborhood Hits	394	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y6R0, Q7Z4J9	Gene names	NUMBL
Domain Architecture
Description	Numb-like protein (Numb-R).

SAMN1_HUMAN
NC score	0.145144 (rank : 311)	θ value	0.000121331 (rank : 229)
Query Neighborhood Hits	453	Target Neighborhood Hits	74	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

CMTA2_MOUSE
NC score	0.135560 (rank : 312)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	453	Target Neighborhood Hits	216	Shared Neighborhood Hits	79
SwissProt Accessions	Q80Y50, Q3TFK0, Q5SX68, Q80TP1, Q8R0D9, Q8R2N5	Gene names	Camta2, Kiaa0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

TRPC3_HUMAN
NC score	0.129801 (rank : 313)	θ value	0.00665767 (rank : 305)
Query Neighborhood Hits	453	Target Neighborhood Hits	137	Shared Neighborhood Hits	83
SwissProt Accessions	Q13507, O00593, Q15660	Gene names	TRPC3, TRP3
Domain Architecture
Description	Short transient receptor potential channel 3 (TrpC3) (Htrp-3) (Htrp3).

LRRK1_MOUSE
NC score	0.127399 (rank : 314)	θ value	0.00020696 (rank : 238)
Query Neighborhood Hits	453	Target Neighborhood Hits	1267	Shared Neighborhood Hits	154
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

ANKF1_HUMAN
NC score	0.127326 (rank : 315)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	453	Target Neighborhood Hits	126	Shared Neighborhood Hits	74
SwissProt Accessions	Q8N957	Gene names	ANKFN1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and fibronectin type-III domain-containing protein 1.

TRPC6_MOUSE
NC score	0.123035 (rank : 316)	θ value	0.00228821 (rank : 284)
Query Neighborhood Hits	453	Target Neighborhood Hits	171	Shared Neighborhood Hits	91
SwissProt Accessions	Q61143, Q9Z2J1	Gene names	Trpc6, Trp6, Trrp6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6) (Calcium entry channel).

TRPC3_MOUSE
NC score	0.121818 (rank : 317)	θ value	0.00390308 (rank : 292)
Query Neighborhood Hits	453	Target Neighborhood Hits	131	Shared Neighborhood Hits	79
SwissProt Accessions	Q9QZC1, Q61058	Gene names	Trpc3, Trp3, Trrp3
Domain Architecture
Description	Short transient receptor potential channel 3 (TrpC3) (Transient receptor protein 3) (Mtrp3) (Receptor-activated cation channel TRP3) (trp-related protein 3).

DAB1_MOUSE
NC score	0.115673 (rank : 318)	θ value	0.00102713 (rank : 266)
Query Neighborhood Hits	453	Target Neighborhood Hits	145	Shared Neighborhood Hits	22
SwissProt Accessions	P97318, P97316, P97317	Gene names	Dab1
Domain Architecture
Description	Disabled homolog 1.

DAB2_MOUSE
NC score	0.115649 (rank : 319)	θ value	0.00134147 (rank : 271)
Query Neighborhood Hits	453	Target Neighborhood Hits	163	Shared Neighborhood Hits	21
SwissProt Accessions	P98078, Q3U3K1, Q91W56, Q923E1	Gene names	Dab2, Doc2
Domain Architecture
Description	Disabled homolog 2 (DOC-2) (Mitogen-responsive phosphoprotein).

TRPC7_HUMAN
NC score	0.115463 (rank : 320)	θ value	0.0193708 (rank : 317)
Query Neighborhood Hits	453	Target Neighborhood Hits	123	Shared Neighborhood Hits	74
SwissProt Accessions	Q9HCX4	Gene names	TRPC7, TRP7
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (TRP7 protein).

DAB2_HUMAN
NC score	0.115379 (rank : 321)	θ value	7.1131e-05 (rank : 222)
Query Neighborhood Hits	453	Target Neighborhood Hits	197	Shared Neighborhood Hits	22
SwissProt Accessions	P98082, Q13598, Q9BTY0, Q9UK04	Gene names	DAB2, DOC2
Domain Architecture
Description	Disabled homolog 2 (Differentially expressed protein 2) (DOC-2).

DAB1_HUMAN
NC score	0.115372 (rank : 322)	θ value	0.00102713 (rank : 265)
Query Neighborhood Hits	453	Target Neighborhood Hits	219	Shared Neighborhood Hits	25
SwissProt Accessions	O75553, Q9NYA8	Gene names	DAB1
Domain Architecture
Description	Disabled homolog 1.

TRPC7_MOUSE
NC score	0.115190 (rank : 323)	θ value	0.0193708 (rank : 318)
Query Neighborhood Hits	453	Target Neighborhood Hits	114	Shared Neighborhood Hits	74
SwissProt Accessions	Q9WVC5	Gene names	Trpc7, Trp7, Trrp8
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (mTRP7).

TRPV4_HUMAN
NC score	0.114003 (rank : 324)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	453	Target Neighborhood Hits	150	Shared Neighborhood Hits	83
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

JIP1_MOUSE
NC score	0.113969 (rank : 325)	θ value	0.000461057 (rank : 251)
Query Neighborhood Hits	453	Target Neighborhood Hits	259	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP1_HUMAN
NC score	0.113727 (rank : 326)	θ value	0.00175202 (rank : 276)
Query Neighborhood Hits	453	Target Neighborhood Hits	271	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

SHC2_MOUSE
NC score	0.107106 (rank : 327)	θ value	2.44474e-05 (rank : 201)
Query Neighborhood Hits	453	Target Neighborhood Hits	144	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC2_HUMAN
NC score	0.106880 (rank : 328)	θ value	4.1701e-05 (rank : 214)
Query Neighborhood Hits	453	Target Neighborhood Hits	170	Shared Neighborhood Hits	19
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

TRPV4_MOUSE
NC score	0.105969 (rank : 329)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	453	Target Neighborhood Hits	117	Shared Neighborhood Hits	78
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

SHC3_HUMAN
NC score	0.104159 (rank : 330)	θ value	4.1701e-05 (rank : 215)
Query Neighborhood Hits	453	Target Neighborhood Hits	155	Shared Neighborhood Hits	16
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
NC score	0.103837 (rank : 331)	θ value	4.1701e-05 (rank : 216)
Query Neighborhood Hits	453	Target Neighborhood Hits	151	Shared Neighborhood Hits	17
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHC1_HUMAN
NC score	0.103676 (rank : 332)	θ value	4.1701e-05 (rank : 212)
Query Neighborhood Hits	453	Target Neighborhood Hits	170	Shared Neighborhood Hits	20
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

LRRK1_HUMAN
NC score	0.103299 (rank : 333)	θ value	0.000602161 (rank : 256)
Query Neighborhood Hits	453	Target Neighborhood Hits	1237	Shared Neighborhood Hits	128
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

SHC1_MOUSE
NC score	0.102864 (rank : 334)	θ value	4.1701e-05 (rank : 213)
Query Neighborhood Hits	453	Target Neighborhood Hits	180	Shared Neighborhood Hits	19
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

JIP2_HUMAN
NC score	0.096389 (rank : 335)	θ value	0.00175202 (rank : 277)
Query Neighborhood Hits	453	Target Neighborhood Hits	288	Shared Neighborhood Hits	37
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

TBCD4_MOUSE
NC score	0.092612 (rank : 336)	θ value	3.77169e-06 (rank : 181)
Query Neighborhood Hits	453	Target Neighborhood Hits	276	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BYJ6, Q5DU23, Q66JU2, Q6P2M2, Q8BMH6, Q8BXM2	Gene names	Tbc1d4, Kiaa0603
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160).

EPHA6_HUMAN
NC score	0.089796 (rank : 337)	θ value	0.00102713 (rank : 268)
Query Neighborhood Hits	453	Target Neighborhood Hits	959	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

JIP2_MOUSE
NC score	0.089174 (rank : 338)	θ value	0.00175202 (rank : 278)
Query Neighborhood Hits	453	Target Neighborhood Hits	144	Shared Neighborhood Hits	21
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

EPHA5_HUMAN
NC score	0.088914 (rank : 339)	θ value	0.000602161 (rank : 255)
Query Neighborhood Hits	453	Target Neighborhood Hits	1009	Shared Neighborhood Hits	72
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHB3_HUMAN
NC score	0.088332 (rank : 340)	θ value	3.19293e-05 (rank : 203)
Query Neighborhood Hits	453	Target Neighborhood Hits	996	Shared Neighborhood Hits	67
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHA6_MOUSE
NC score	0.088254 (rank : 341)	θ value	0.00298849 (rank : 286)
Query Neighborhood Hits	453	Target Neighborhood Hits	946	Shared Neighborhood Hits	62
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA7_HUMAN
NC score	0.087320 (rank : 342)	θ value	0.00228821 (rank : 281)
Query Neighborhood Hits	453	Target Neighborhood Hits	1053	Shared Neighborhood Hits	71
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA1_MOUSE
NC score	0.087114 (rank : 343)	θ value	0.00102713 (rank : 267)
Query Neighborhood Hits	453	Target Neighborhood Hits	958	Shared Neighborhood Hits	64
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHA2_MOUSE
NC score	0.086977 (rank : 344)	θ value	0.000270298 (rank : 242)
Query Neighborhood Hits	453	Target Neighborhood Hits	1020	Shared Neighborhood Hits	67
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHB3_MOUSE
NC score	0.086808 (rank : 345)	θ value	0.00020696 (rank : 237)
Query Neighborhood Hits	453	Target Neighborhood Hits	996	Shared Neighborhood Hits	64
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

EPHA2_HUMAN
NC score	0.086791 (rank : 346)	θ value	0.000158464 (rank : 231)
Query Neighborhood Hits	453	Target Neighborhood Hits	1021	Shared Neighborhood Hits	68
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHB2_HUMAN
NC score	0.086788 (rank : 347)	θ value	0.00102713 (rank : 269)
Query Neighborhood Hits	453	Target Neighborhood Hits	983	Shared Neighborhood Hits	66
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHA1_HUMAN
NC score	0.086743 (rank : 348)	θ value	0.00298849 (rank : 285)
Query Neighborhood Hits	453	Target Neighborhood Hits	997	Shared Neighborhood Hits	69
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHB4_HUMAN
NC score	0.086739 (rank : 349)	θ value	0.0113563 (rank : 313)
Query Neighborhood Hits	453	Target Neighborhood Hits	1056	Shared Neighborhood Hits	73
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

EPHA8_MOUSE
NC score	0.086662 (rank : 350)	θ value	0.00175202 (rank : 275)
Query Neighborhood Hits	453	Target Neighborhood Hits	969	Shared Neighborhood Hits	63
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

TRPC5_MOUSE
NC score	0.086623 (rank : 351)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	453	Target Neighborhood Hits	124	Shared Neighborhood Hits	73
SwissProt Accessions	Q9QX29, Q61059, Q9QWT1, Q9R0D4	Gene names	Trpc5, Trp5, Trrp5
Domain Architecture
Description	Short transient receptor potential channel 5 (TrpC5) (Transient receptor protein 5) (Mtrp5) (trp-related protein 5) (Capacitative calcium entry channel 2) (CCE2).

EPHA7_MOUSE
NC score	0.086614 (rank : 352)	θ value	0.00509761 (rank : 298)
Query Neighborhood Hits	453	Target Neighborhood Hits	1025	Shared Neighborhood Hits	69
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHB6_MOUSE
NC score	0.086512 (rank : 353)	θ value	0.813845 (rank : 354)
Query Neighborhood Hits	453	Target Neighborhood Hits	906	Shared Neighborhood Hits	60
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

EPHB6_HUMAN
NC score	0.086293 (rank : 354)	θ value	1.81305 (rank : 379)
Query Neighborhood Hits	453	Target Neighborhood Hits	912	Shared Neighborhood Hits	62
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

SAM14_MOUSE
NC score	0.086164 (rank : 355)	θ value	0.0736092 (rank : 330)
Query Neighborhood Hits	453	Target Neighborhood Hits	91	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K070, Q5SWB7, Q8BHE2, Q8C8N5	Gene names	Samd14
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 14.

EPHAA_HUMAN
NC score	0.085659 (rank : 356)	θ value	0.0193708 (rank : 316)
Query Neighborhood Hits	453	Target Neighborhood Hits	960	Shared Neighborhood Hits	63
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHB4_MOUSE
NC score	0.085470 (rank : 357)	θ value	0.00869519 (rank : 310)
Query Neighborhood Hits	453	Target Neighborhood Hits	1013	Shared Neighborhood Hits	68
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHB2_MOUSE
NC score	0.085455 (rank : 358)	θ value	0.00228821 (rank : 282)
Query Neighborhood Hits	453	Target Neighborhood Hits	982	Shared Neighborhood Hits	66
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

TBCD4_HUMAN
NC score	0.084473 (rank : 359)	θ value	0.000158464 (rank : 232)
Query Neighborhood Hits	453	Target Neighborhood Hits	357	Shared Neighborhood Hits	36
SwissProt Accessions	O60343, Q5W0B9	Gene names	TBC1D4, KIAA0603
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160).

TRPC5_HUMAN
NC score	0.084437 (rank : 360)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	453	Target Neighborhood Hits	122	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UL62, O75233, Q5JXY8, Q9Y514	Gene names	TRPC5, TRP5
Domain Architecture
Description	Short transient receptor potential channel 5 (TrpC5) (Htrp-5) (Htrp5).

EPHA8_HUMAN
NC score	0.084432 (rank : 361)	θ value	0.00390308 (rank : 291)
Query Neighborhood Hits	453	Target Neighborhood Hits	956	Shared Neighborhood Hits	63
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHB1_HUMAN
NC score	0.084035 (rank : 362)	θ value	0.00665767 (rank : 301)
Query Neighborhood Hits	453	Target Neighborhood Hits	988	Shared Neighborhood Hits	68
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

TRPC4_MOUSE
NC score	0.083944 (rank : 363)	θ value	8.99809 (rank : 452)
Query Neighborhood Hits	453	Target Neighborhood Hits	141	Shared Neighborhood Hits	75
SwissProt Accessions	Q9QUQ5, Q62350, Q9QUQ9, Q9QZC0	Gene names	Trpc4, Trrp4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (Receptor- activated cation channel TRP4) (Capacitative calcium entry channel Trp4).

TRPC4_HUMAN
NC score	0.083908 (rank : 364)	θ value	8.99809 (rank : 451)
Query Neighborhood Hits	453	Target Neighborhood Hits	140	Shared Neighborhood Hits	75
SwissProt Accessions	Q9UBN4, Q15721, Q9UIB0, Q9UIB1, Q9UIB2	Gene names	TRPC4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (trp-related protein 4) (hTrp-4) (hTrp4).

SAM14_HUMAN
NC score	0.083333 (rank : 365)	θ value	0.0563607 (rank : 327)
Query Neighborhood Hits	453	Target Neighborhood Hits	81	Shared Neighborhood Hits	27
SwissProt Accessions	Q8IZD0, Q8N2X0	Gene names	SAMD14
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 14.

LIPB2_MOUSE
NC score	0.082266 (rank : 366)	θ value	0.00665767 (rank : 303)
Query Neighborhood Hits	453	Target Neighborhood Hits	570	Shared Neighborhood Hits	43
SwissProt Accessions	O35711, Q7TMG4, Q8CBS6, Q99KX6	Gene names	Ppfibp2, Cclp1
Domain Architecture
Description	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) (Coiled-coil-like protein 1).

SHAN2_HUMAN
NC score	0.082130 (rank : 367)	θ value	1.38821 (rank : 375)
Query Neighborhood Hits	453	Target Neighborhood Hits	346	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

SHAN2_MOUSE
NC score	0.082087 (rank : 368)	θ value	1.38821 (rank : 376)
Query Neighborhood Hits	453	Target Neighborhood Hits	446	Shared Neighborhood Hits	65
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

EPHA4_MOUSE
NC score	0.081982 (rank : 369)	θ value	0.0736092 (rank : 329)
Query Neighborhood Hits	453	Target Neighborhood Hits	982	Shared Neighborhood Hits	64
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA4_HUMAN
NC score	0.081576 (rank : 370)	θ value	0.125558 (rank : 335)
Query Neighborhood Hits	453	Target Neighborhood Hits	975	Shared Neighborhood Hits	64
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA5_MOUSE
NC score	0.080869 (rank : 371)	θ value	0.00390308 (rank : 290)
Query Neighborhood Hits	453	Target Neighborhood Hits	950	Shared Neighborhood Hits	66
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

LIPB2_HUMAN
NC score	0.080387 (rank : 372)	θ value	0.0431538 (rank : 322)
Query Neighborhood Hits	453	Target Neighborhood Hits	599	Shared Neighborhood Hits	40
SwissProt Accessions	Q8ND30, O75337, Q8WW26	Gene names	PPFIBP2
Domain Architecture
Description	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2).

CU081_HUMAN
NC score	0.076774 (rank : 373)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	453	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NFU9	Gene names	C21orf81
Domain Architecture	No domain graphic available
Description	Protein C21orf81.

APBA3_MOUSE
NC score	0.076758 (rank : 374)	θ value	0.000602161 (rank : 254)
Query Neighborhood Hits	453	Target Neighborhood Hits	174	Shared Neighborhood Hits	19
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

SARM1_MOUSE
NC score	0.076623 (rank : 375)	θ value	1.81305 (rank : 382)
Query Neighborhood Hits	453	Target Neighborhood Hits	54	Shared Neighborhood Hits	27
SwissProt Accessions	Q6PDS3, Q5SYG5, Q5SYG6, Q6A054, Q6SZW0, Q8BRI9	Gene names	Sarm1, Kiaa0524
Domain Architecture	No domain graphic available
Description	Sterile alpha and TIR motif-containing protein 1 (Tir-1 homolog).

LIPB1_HUMAN
NC score	0.076389 (rank : 376)	θ value	0.00665767 (rank : 302)
Query Neighborhood Hits	453	Target Neighborhood Hits	640	Shared Neighborhood Hits	52
SwissProt Accessions	Q86W92, O75336, Q86X70, Q9NY03, Q9ULJ0	Gene names	PPFIBP1, KIAA1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2).

APBA2_HUMAN
NC score	0.075532 (rank : 377)	θ value	0.00102713 (rank : 262)
Query Neighborhood Hits	453	Target Neighborhood Hits	220	Shared Neighborhood Hits	21
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA1_HUMAN
NC score	0.074191 (rank : 378)	θ value	0.00102713 (rank : 261)
Query Neighborhood Hits	453	Target Neighborhood Hits	325	Shared Neighborhood Hits	25
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

TBCD1_HUMAN
NC score	0.073952 (rank : 379)	θ value	0.00869519 (rank : 311)
Query Neighborhood Hits	453	Target Neighborhood Hits	276	Shared Neighborhood Hits	24
SwissProt Accessions	Q86TI0, Q96K82, Q9UPP4	Gene names	TBC1D1, KIAA1108
Domain Architecture
Description	TBC1 domain family member 1.

TBCD1_MOUSE
NC score	0.073809 (rank : 380)	θ value	0.00665767 (rank : 304)
Query Neighborhood Hits	453	Target Neighborhood Hits	241	Shared Neighborhood Hits	21
SwissProt Accessions	Q60949, Q80TJ9, Q923F8	Gene names	Tbc1d1, Kiaa1108, Tbc1
Domain Architecture
Description	TBC1 domain family member 1.

EPHA3_HUMAN
NC score	0.072924 (rank : 381)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	453	Target Neighborhood Hits	1005	Shared Neighborhood Hits	55
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA3_MOUSE
NC score	0.072886 (rank : 382)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	453	Target Neighborhood Hits	1009	Shared Neighborhood Hits	55
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

LIPB1_MOUSE
NC score	0.071314 (rank : 383)	θ value	0.00298849 (rank : 288)
Query Neighborhood Hits	453	Target Neighborhood Hits	727	Shared Neighborhood Hits	51
SwissProt Accessions	Q8C8U0, Q69ZN5, Q6GQV3, Q80VB4, Q9CUT7	Gene names	Ppfibp1, Kiaa1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1).

APBA2_MOUSE
NC score	0.069842 (rank : 384)	θ value	0.00509761 (rank : 295)
Query Neighborhood Hits	453	Target Neighborhood Hits	219	Shared Neighborhood Hits	19
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

DGKD_HUMAN
NC score	0.068949 (rank : 385)	θ value	1.06291 (rank : 363)
Query Neighborhood Hits	453	Target Neighborhood Hits	231	Shared Neighborhood Hits	60
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

TRPC1_HUMAN
NC score	0.066500 (rank : 386)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	453	Target Neighborhood Hits	91	Shared Neighborhood Hits	52
SwissProt Accessions	P48995	Gene names	TRPC1, TRP1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (TRP-1 protein).

SARM1_HUMAN
NC score	0.064310 (rank : 387)	θ value	3.0926 (rank : 393)
Query Neighborhood Hits	453	Target Neighborhood Hits	58	Shared Neighborhood Hits	21
SwissProt Accessions	Q6SZW1, O60277, Q7LGG3, Q9NXY5	Gene names	SARM1, KIAA0524, SARM
Domain Architecture	No domain graphic available
Description	Sterile alpha and TIR motif-containing protein 1 (Sterile alpha and Armadillo repeat protein) (Tir-1 homolog).

RIPK2_HUMAN
NC score	0.062733 (rank : 388)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	453	Target Neighborhood Hits	774	Shared Neighborhood Hits	46
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

TRPC1_MOUSE
NC score	0.061721 (rank : 389)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	453	Target Neighborhood Hits	87	Shared Neighborhood Hits	48
SwissProt Accessions	Q61056, O35722	Gene names	Trpc1, Trp1, Trrp1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (Mtrp1) (Trp-related protein 1).

CEND3_HUMAN
NC score	0.059193 (rank : 390)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	453	Target Neighborhood Hits	275	Shared Neighborhood Hits	66
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

MLKL_HUMAN
NC score	0.058236 (rank : 391)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	453	Target Neighborhood Hits	600	Shared Neighborhood Hits	41
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

CEND3_MOUSE
NC score	0.057283 (rank : 392)	θ value	8.99809 (rank : 438)
Query Neighborhood Hits	453	Target Neighborhood Hits	228	Shared Neighborhood Hits	62
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

RIPK2_MOUSE
NC score	0.056889 (rank : 393)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	453	Target Neighborhood Hits	776	Shared Neighborhood Hits	44
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

DGKH_HUMAN
NC score	0.056776 (rank : 394)	θ value	1.81305 (rank : 378)
Query Neighborhood Hits	453	Target Neighborhood Hits	255	Shared Neighborhood Hits	57
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

CEND1_HUMAN
NC score	0.055582 (rank : 395)	θ value	5.27518 (rank : 411)
Query Neighborhood Hits	453	Target Neighborhood Hits	284	Shared Neighborhood Hits	61
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

IRAK3_HUMAN
NC score	0.055518 (rank : 396)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	453	Target Neighborhood Hits	644	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

TIE1_HUMAN
NC score	0.055075 (rank : 397)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	453	Target Neighborhood Hits	1241	Shared Neighborhood Hits	55
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE1_MOUSE
NC score	0.055023 (rank : 398)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	453	Target Neighborhood Hits	1266	Shared Neighborhood Hits	55
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE2_MOUSE
NC score	0.054394 (rank : 399)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	453	Target Neighborhood Hits	1204	Shared Neighborhood Hits	57
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

TIE2_HUMAN
NC score	0.054266 (rank : 400)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	453	Target Neighborhood Hits	1192	Shared Neighborhood Hits	56
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

IRAK3_MOUSE
NC score	0.054075 (rank : 401)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	453	Target Neighborhood Hits	628	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

FER_HUMAN
NC score	0.053950 (rank : 402)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	453	Target Neighborhood Hits	1278	Shared Neighborhood Hits	67
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

SSB4_HUMAN
NC score	0.053811 (rank : 403)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	453	Target Neighborhood Hits	47	Shared Neighborhood Hits	25
SwissProt Accessions	Q96A44	Gene names	SPSB4, SSB4
Domain Architecture	No domain graphic available
Description	SPRY domain-containing SOCS box protein 4 (SSB-4).

LIPA4_HUMAN
NC score	0.053805 (rank : 404)	θ value	0.813845 (rank : 356)
Query Neighborhood Hits	453	Target Neighborhood Hits	56	Shared Neighborhood Hits	20
SwissProt Accessions	O75335, O94971	Gene names	PPFIA4, KIAA0897
Domain Architecture
Description	Liprin-alpha-4 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4) (PTPRF-interacting protein alpha-4).

LIPA3_MOUSE
NC score	0.052697 (rank : 405)	θ value	1.06291 (rank : 367)
Query Neighborhood Hits	453	Target Neighborhood Hits	636	Shared Neighborhood Hits	41
SwissProt Accessions	P60469	Gene names	Ppfia3
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

FGR_MOUSE
NC score	0.052678 (rank : 406)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	453	Target Neighborhood Hits	1069	Shared Neighborhood Hits	66
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

YES_HUMAN
NC score	0.052258 (rank : 407)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	453	Target Neighborhood Hits	1059	Shared Neighborhood Hits	63
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FYN_MOUSE
NC score	0.052066 (rank : 408)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	453	Target Neighborhood Hits	1073	Shared Neighborhood Hits	66
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

YES_MOUSE
NC score	0.051937 (rank : 409)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	453	Target Neighborhood Hits	1052	Shared Neighborhood Hits	62
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

GUC2G_MOUSE
NC score	0.051921 (rank : 410)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	453	Target Neighborhood Hits	644	Shared Neighborhood Hits	39
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

FGR_HUMAN
NC score	0.051661 (rank : 411)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	453	Target Neighborhood Hits	1067	Shared Neighborhood Hits	67
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FYN_HUMAN
NC score	0.051637 (rank : 412)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	453	Target Neighborhood Hits	1078	Shared Neighborhood Hits	68
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

MLKL_MOUSE
NC score	0.051539 (rank : 413)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	453	Target Neighborhood Hits	707	Shared Neighborhood Hits	43
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

FADD_MOUSE
NC score	0.051519 (rank : 414)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	453	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	Q61160, Q3TC37, Q61082	Gene names	Fadd, Mort1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

FRK_HUMAN
NC score	0.051281 (rank : 415)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	453	Target Neighborhood Hits	1058	Shared Neighborhood Hits	64
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

TNK1_HUMAN
NC score	0.051171 (rank : 416)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	453	Target Neighborhood Hits	815	Shared Neighborhood Hits	50
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

ERBB4_HUMAN
NC score	0.051060 (rank : 417)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	453	Target Neighborhood Hits	910	Shared Neighborhood Hits	52
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

M3K10_HUMAN
NC score	0.050871 (rank : 418)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	453	Target Neighborhood Hits	1071	Shared Neighborhood Hits	66
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

ZAP70_HUMAN
NC score	0.050780 (rank : 419)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	453	Target Neighborhood Hits	893	Shared Neighborhood Hits	52
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

M3K11_HUMAN
NC score	0.050768 (rank : 420)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	453	Target Neighborhood Hits	1136	Shared Neighborhood Hits	70
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

RIPK3_HUMAN
NC score	0.050739 (rank : 421)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	453	Target Neighborhood Hits	828	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

SRC_HUMAN
NC score	0.050552 (rank : 422)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	453	Target Neighborhood Hits	1058	Shared Neighborhood Hits	66
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
NC score	0.050529 (rank : 423)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	453	Target Neighborhood Hits	1033	Shared Neighborhood Hits	65
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

FES_MOUSE
NC score	0.050527 (rank : 424)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	453	Target Neighborhood Hits	980	Shared Neighborhood Hits	61
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

TXK_MOUSE
NC score	0.050297 (rank : 425)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	453	Target Neighborhood Hits	980	Shared Neighborhood Hits	61
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

LIPA2_HUMAN
NC score	0.050132 (rank : 426)	θ value	0.21417 (rank : 338)
Query Neighborhood Hits	453	Target Neighborhood Hits	1044	Shared Neighborhood Hits	56
SwissProt Accessions	O75334	Gene names	PPFIA2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

FAK2_HUMAN
NC score	0.050112 (rank : 427)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	453	Target Neighborhood Hits	847	Shared Neighborhood Hits	47
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

CEND1_MOUSE
NC score	0.049770 (rank : 428)	θ value	4.03905 (rank : 400)
Query Neighborhood Hits	453	Target Neighborhood Hits	260	Shared Neighborhood Hits	57
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

LIPA2_MOUSE
NC score	0.047306 (rank : 429)	θ value	0.21417 (rank : 339)
Query Neighborhood Hits	453	Target Neighborhood Hits	1282	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BSS9, Q8BN73	Gene names	Ppfia2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

LIPA3_HUMAN
NC score	0.045969 (rank : 430)	θ value	1.06291 (rank : 366)
Query Neighborhood Hits	453	Target Neighborhood Hits	828	Shared Neighborhood Hits	45
SwissProt Accessions	O75145, Q9H8B5, Q9UEW4	Gene names	PPFIA3, KIAA0654
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

LIPA1_HUMAN
NC score	0.044675 (rank : 431)	θ value	0.279714 (rank : 343)
Query Neighborhood Hits	453	Target Neighborhood Hits	1294	Shared Neighborhood Hits	58
SwissProt Accessions	Q13136, Q13135, Q14567, Q8N4I2	Gene names	PPFIA1, LIP1
Domain Architecture
Description	Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) (LAR-interacting protein 1) (LIP.1).

MDC1_HUMAN
NC score	0.040593 (rank : 432)	θ value	6.88961 (rank : 425)
Query Neighborhood Hits	453	Target Neighborhood Hits	1446	Shared Neighborhood Hits	68
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

WNK2_HUMAN
NC score	0.039944 (rank : 433)	θ value	0.813845 (rank : 359)
Query Neighborhood Hits	453	Target Neighborhood Hits	1407	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

PRRT3_HUMAN
NC score	0.037620 (rank : 434)	θ value	4.03905 (rank : 405)
Query Neighborhood Hits	453	Target Neighborhood Hits	998	Shared Neighborhood Hits	47
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

PRPF3_HUMAN
NC score	0.036709 (rank : 435)	θ value	0.0961366 (rank : 332)
Query Neighborhood Hits	453	Target Neighborhood Hits	65	Shared Neighborhood Hits	8
SwissProt Accessions	O43395, O43446	Gene names	PRPF3, HPRP3, PRP3
Domain Architecture
Description	U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) (U4/U6 snRNP 90 kDa protein) (hPrp3).

GRIN1_HUMAN
NC score	0.036601 (rank : 436)	θ value	1.38821 (rank : 373)
Query Neighborhood Hits	453	Target Neighborhood Hits	681	Shared Neighborhood Hits	49
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

PRPF3_MOUSE
NC score	0.035916 (rank : 437)	θ value	0.0961366 (rank : 333)
Query Neighborhood Hits	453	Target Neighborhood Hits	74	Shared Neighborhood Hits	8
SwissProt Accessions	Q922U1, Q3TJH4, Q9D6C6	Gene names	Prpf3
Domain Architecture
Description	U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3).

STK10_MOUSE
NC score	0.035142 (rank : 438)	θ value	0.62314 (rank : 349)
Query Neighborhood Hits	453	Target Neighborhood Hits	2132	Shared Neighborhood Hits	100
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

LAMA5_HUMAN
NC score	0.034769 (rank : 439)	θ value	2.36792 (rank : 386)
Query Neighborhood Hits	453	Target Neighborhood Hits	976	Shared Neighborhood Hits	47
SwissProt Accessions	O15230, Q8WZA7, Q9H1P1	Gene names	LAMA5, KIAA0533, KIAA1907
Domain Architecture
Description	Laminin alpha-5 chain precursor.

STK10_HUMAN
NC score	0.034148 (rank : 440)	θ value	0.47712 (rank : 346)
Query Neighborhood Hits	453	Target Neighborhood Hits	1921	Shared Neighborhood Hits	98
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

PKHA6_MOUSE
NC score	0.033871 (rank : 441)	θ value	0.163984 (rank : 337)
Query Neighborhood Hits	453	Target Neighborhood Hits	591	Shared Neighborhood Hits	36
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

BSN_HUMAN
NC score	0.033746 (rank : 442)	θ value	5.27518 (rank : 409)
Query Neighborhood Hits	453	Target Neighborhood Hits	1537	Shared Neighborhood Hits	80
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

RP1L1_HUMAN
NC score	0.033639 (rank : 443)	θ value	1.06291 (rank : 368)
Query Neighborhood Hits	453	Target Neighborhood Hits	1072	Shared Neighborhood Hits	56
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

SH2D5_MOUSE
NC score	0.033631 (rank : 444)	θ value	0.62314 (rank : 348)
Query Neighborhood Hits	453	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	Q8JZW5	Gene names	Sh2d5
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 5.

ARI1A_HUMAN
NC score	0.033111 (rank : 445)	θ value	0.279714 (rank : 342)
Query Neighborhood Hits	453	Target Neighborhood Hits	787	Shared Neighborhood Hits	46
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

NFH_MOUSE
NC score	0.032320 (rank : 446)	θ value	0.0431538 (rank : 323)
Query Neighborhood Hits	453	Target Neighborhood Hits	2247	Shared Neighborhood Hits	98
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

CABIN_HUMAN
NC score	0.031113 (rank : 447)	θ value	4.03905 (rank : 398)
Query Neighborhood Hits	453	Target Neighborhood Hits	490	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

YSK4_HUMAN
NC score	0.031003 (rank : 448)	θ value	0.62314 (rank : 350)
Query Neighborhood Hits	453	Target Neighborhood Hits	921	Shared Neighborhood Hits	53
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

CBP_MOUSE
NC score	0.028191 (rank : 449)	θ value	6.88961 (rank : 422)
Query Neighborhood Hits	453	Target Neighborhood Hits	1051	Shared Neighborhood Hits	58
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

WBP11_HUMAN
NC score	0.027509 (rank : 450)	θ value	6.88961 (rank : 434)
Query Neighborhood Hits	453	Target Neighborhood Hits	354	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

CSPG2_HUMAN
NC score	0.027116 (rank : 451)	θ value	5.27518 (rank : 413)
Query Neighborhood Hits	453	Target Neighborhood Hits	681	Shared Neighborhood Hits	23
SwissProt Accessions	P13611, P20754, Q13010, Q13189, Q15123, Q9UCL9, Q9UNW5	Gene names	CSPG2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M) (Glial hyaluronate-binding protein) (GHAP).

COG8_HUMAN
NC score	0.026995 (rank : 452)	θ value	3.0926 (rank : 390)
Query Neighborhood Hits	453	Target Neighborhood Hits	21	Shared Neighborhood Hits	7
SwissProt Accessions	Q96MW5, Q8WVV6, Q9H6F8	Gene names	COG8
Domain Architecture
Description	Conserved oligomeric Golgi complex component 8.

MLL2_HUMAN
NC score	0.026625 (rank : 453)	θ value	8.99809 (rank : 444)
Query Neighborhood Hits	453	Target Neighborhood Hits	1788	Shared Neighborhood Hits	69
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

RERE_HUMAN
NC score	0.026372 (rank : 454)	θ value	8.99809 (rank : 449)
Query Neighborhood Hits	453	Target Neighborhood Hits	779	Shared Neighborhood Hits	61
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

URFB1_HUMAN
NC score	0.024822 (rank : 455)	θ value	0.813845 (rank : 358)
Query Neighborhood Hits	453	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	Q6BDS2, Q9NXE0	Gene names	UHRF1BP1, C6orf107
Domain Architecture	No domain graphic available
Description	UHRF1-binding protein 1 (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) (ICBP90-binding protein 1).

MDN1_HUMAN
NC score	0.022148 (rank : 456)	θ value	8.99809 (rank : 443)
Query Neighborhood Hits	453	Target Neighborhood Hits	662	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

KKCC1_HUMAN
NC score	0.021455 (rank : 457)	θ value	6.88961 (rank : 424)
Query Neighborhood Hits	453	Target Neighborhood Hits	858	Shared Neighborhood Hits	46
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

SRBS1_MOUSE
NC score	0.020521 (rank : 458)	θ value	5.27518 (rank : 418)
Query Neighborhood Hits	453	Target Neighborhood Hits	409	Shared Neighborhood Hits	36
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

TENS4_MOUSE
NC score	0.020408 (rank : 459)	θ value	2.36792 (rank : 389)
Query Neighborhood Hits	453	Target Neighborhood Hits	225	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

ARI1B_HUMAN
NC score	0.019050 (rank : 460)	θ value	8.99809 (rank : 436)
Query Neighborhood Hits	453	Target Neighborhood Hits	567	Shared Neighborhood Hits	38
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

COG8_MOUSE
NC score	0.017313 (rank : 461)	θ value	8.99809 (rank : 441)
Query Neighborhood Hits	453	Target Neighborhood Hits	147	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JJA2	Gene names	Cog8
Domain Architecture
Description	Conserved oligomeric Golgi complex component 8.

SYP2L_HUMAN
NC score	0.016759 (rank : 462)	θ value	1.81305 (rank : 383)
Query Neighborhood Hits	453	Target Neighborhood Hits	400	Shared Neighborhood Hits	29
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

HORN_MOUSE
NC score	0.016327 (rank : 463)	θ value	1.81305 (rank : 381)
Query Neighborhood Hits	453	Target Neighborhood Hits	218	Shared Neighborhood Hits	10
SwissProt Accessions	Q8VHD8	Gene names	Hrnr
Domain Architecture
Description	Hornerin.

NPBL_MOUSE
NC score	0.015451 (rank : 464)	θ value	1.38821 (rank : 374)
Query Neighborhood Hits	453	Target Neighborhood Hits	1041	Shared Neighborhood Hits	46
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

SAMD4_MOUSE
NC score	0.015360 (rank : 465)	θ value	6.88961 (rank : 429)
Query Neighborhood Hits	453	Target Neighborhood Hits	25	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CBY1	Gene names	Samd4
Domain Architecture
Description	Sterile alpha motif domain-containing protein 4.

HIPK3_HUMAN
NC score	0.014270 (rank : 466)	θ value	1.06291 (rank : 365)
Query Neighborhood Hits	453	Target Neighborhood Hits	867	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

HIPK3_MOUSE
NC score	0.014259 (rank : 467)	θ value	0.813845 (rank : 355)
Query Neighborhood Hits	453	Target Neighborhood Hits	857	Shared Neighborhood Hits	44
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

AKAP6_HUMAN
NC score	0.013463 (rank : 468)	θ value	4.03905 (rank : 397)
Query Neighborhood Hits	453	Target Neighborhood Hits	263	Shared Neighborhood Hits	10
SwissProt Accessions	Q13023, O15028	Gene names	AKAP6, AKAP100, KIAA0311
Domain Architecture
Description	A-kinase anchor protein 6 (Protein kinase A-anchoring protein 6) (PRKA6) (A-kinase anchor protein 100 kDa) (AKAP 100) (mAKAP).

NHS_HUMAN
NC score	0.012845 (rank : 469)	θ value	8.99809 (rank : 446)
Query Neighborhood Hits	453	Target Neighborhood Hits	198	Shared Neighborhood Hits	14
SwissProt Accessions	Q6T4R5, Q5J7Q0, Q5J7Q1, Q68DR5	Gene names	NHS
Domain Architecture	No domain graphic available
Description	Nance-Horan syndrome protein (Congenital cataracts and dental anomalies protein).

GP73_HUMAN
NC score	0.012781 (rank : 470)	θ value	6.88961 (rank : 423)
Query Neighborhood Hits	453	Target Neighborhood Hits	309	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NBJ4, Q6IAF4, Q9NRB9	Gene names	GOLPH2
Domain Architecture	No domain graphic available
Description	Golgi phosphoprotein 2 (Golgi membrane protein GP73).

CNTP1_MOUSE
NC score	0.012354 (rank : 471)	θ value	5.27518 (rank : 412)
Query Neighborhood Hits	453	Target Neighborhood Hits	183	Shared Neighborhood Hits	16
SwissProt Accessions	O54991	Gene names	Cntnap1, Nrxn4
Domain Architecture
Description	Contactin-associated protein 1 precursor (Caspr) (Caspr1) (Neurexin 4) (Neurexin IV) (Paranodin) (NCP1) (MHDNIV).

SAMD4_HUMAN
NC score	0.012169 (rank : 472)	θ value	6.88961 (rank : 428)
Query Neighborhood Hits	453	Target Neighborhood Hits	21	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UPU9	Gene names	SAMD4, KIAA1053
Domain Architecture
Description	Sterile alpha motif domain-containing protein 4.

CNTP1_HUMAN
NC score	0.011544 (rank : 473)	θ value	8.99809 (rank : 440)
Query Neighborhood Hits	453	Target Neighborhood Hits	196	Shared Neighborhood Hits	15
SwissProt Accessions	P78357	Gene names	CNTNAP1, CASPR, NRXN4
Domain Architecture
Description	Contactin-associated protein 1 precursor (Caspr) (Caspr1) (Neurexin 4) (Neurexin IV) (p190).

MELPH_MOUSE
NC score	0.011021 (rank : 474)	θ value	2.36792 (rank : 387)
Query Neighborhood Hits	453	Target Neighborhood Hits	112	Shared Neighborhood Hits	10
SwissProt Accessions	Q91V27, Q99N53	Gene names	Mlph, Ln, Slac2a
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Leaden protein) (Synaptotagmin-like protein 2a) (Slac2-a) (Slp homolog lacking C2 domains a).

HORN_HUMAN
NC score	0.010933 (rank : 475)	θ value	3.0926 (rank : 391)
Query Neighborhood Hits	453	Target Neighborhood Hits	206	Shared Neighborhood Hits	13
SwissProt Accessions	Q86YZ3	Gene names	HRNR, S100A18
Domain Architecture	No domain graphic available
Description	Hornerin.

CBX4_MOUSE
NC score	0.009914 (rank : 476)	θ value	4.03905 (rank : 399)
Query Neighborhood Hits	453	Target Neighborhood Hits	64	Shared Neighborhood Hits	6
SwissProt Accessions	O55187	Gene names	Cbx4, Pc2
Domain Architecture
Description	Chromobox protein homolog 4 (Polycomb 2 homolog) (Pc2) (mPc2).

3BP1_MOUSE
NC score	0.009852 (rank : 477)	θ value	5.27518 (rank : 408)
Query Neighborhood Hits	453	Target Neighborhood Hits	238	Shared Neighborhood Hits	20
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

ADDA_MOUSE
NC score	0.009319 (rank : 478)	θ value	4.03905 (rank : 396)
Query Neighborhood Hits	453	Target Neighborhood Hits	198	Shared Neighborhood Hits	16
SwissProt Accessions	Q9QYC0, Q9JLE3	Gene names	Add1
Domain Architecture
Description	Alpha-adducin (Erythrocyte adducin subunit alpha).

THNSL_HUMAN
NC score	0.008815 (rank : 479)	θ value	3.0926 (rank : 394)
Query Neighborhood Hits	453	Target Neighborhood Hits	47	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IYQ7, Q5VV21	Gene names	THNSL1
Domain Architecture	No domain graphic available
Description	Threonine synthase-like 1.

CD008_HUMAN
NC score	0.008687 (rank : 480)	θ value	8.99809 (rank : 437)
Query Neighborhood Hits	453	Target Neighborhood Hits	330	Shared Neighborhood Hits	20
SwissProt Accessions	P78312, O43607, P78311, P78313, Q9UEG8	Gene names	C4orf8
Domain Architecture	No domain graphic available
Description	Protein C4orf8 (Protein IT14).

DNL1_HUMAN
NC score	0.008639 (rank : 481)	θ value	8.99809 (rank : 442)
Query Neighborhood Hits	453	Target Neighborhood Hits	216	Shared Neighborhood Hits	13
SwissProt Accessions	P18858	Gene names	LIG1
Domain Architecture
Description	DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1).

UBP42_HUMAN
NC score	0.008307 (rank : 482)	θ value	6.88961 (rank : 433)
Query Neighborhood Hits	453	Target Neighborhood Hits	445	Shared Neighborhood Hits	28
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

ZO1_HUMAN
NC score	0.008303 (rank : 483)	θ value	6.88961 (rank : 435)
Query Neighborhood Hits	453	Target Neighborhood Hits	474	Shared Neighborhood Hits	22
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

TIM_MOUSE
NC score	0.007583 (rank : 484)	θ value	4.03905 (rank : 406)
Query Neighborhood Hits	453	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R1X4, Q63ZX9, Q6P204, Q6PDL4, Q7TPV8, Q8R0Q2, Q9R268, Q9Z0E7	Gene names	Timeless, Tim1, Timeless1
Domain Architecture	No domain graphic available
Description	Timeless homolog (mTim).

STIM2_HUMAN
NC score	0.007474 (rank : 485)	θ value	8.99809 (rank : 450)
Query Neighborhood Hits	453	Target Neighborhood Hits	420	Shared Neighborhood Hits	18
SwissProt Accessions	Q9P246, Q96BF1, Q9BQH2, Q9H8R1	Gene names	STIM2, KIAA1482
Domain Architecture
Description	Stromal interaction molecule 2 precursor.

TCAL4_HUMAN
NC score	0.007381 (rank : 486)	θ value	6.88961 (rank : 432)
Query Neighborhood Hits	453	Target Neighborhood Hits	76	Shared Neighborhood Hits	7
SwissProt Accessions	Q96EI5, Q8WY12, Q9H2H1, Q9H775	Gene names	TCEAL4
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 4 (TCEA-like protein 4) (Transcription elongation factor S-II protein-like 4).

FANCM_HUMAN
NC score	0.006787 (rank : 487)	θ value	4.03905 (rank : 402)
Query Neighborhood Hits	453	Target Neighborhood Hits	210	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

SERC_MOUSE
NC score	0.006651 (rank : 488)	θ value	6.88961 (rank : 430)
Query Neighborhood Hits	453	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	Q99K85	Gene names	Psat1, Psa, Psat
Domain Architecture
Description	Phosphoserine aminotransferase (EC 2.6.1.52) (PSAT) (Endometrial progesterone-induced protein) (EPIP).

RECQ5_HUMAN
NC score	0.004589 (rank : 489)	θ value	6.88961 (rank : 426)
Query Neighborhood Hits	453	Target Neighborhood Hits	390	Shared Neighborhood Hits	19
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

RGNEF_MOUSE
NC score	0.004476 (rank : 490)	θ value	6.88961 (rank : 427)
Query Neighborhood Hits	453	Target Neighborhood Hits	641	Shared Neighborhood Hits	32
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

STON2_HUMAN
NC score	0.003937 (rank : 491)	θ value	6.88961 (rank : 431)
Query Neighborhood Hits	453	Target Neighborhood Hits	115	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WXE9, Q6NT47, Q96RI7, Q96RU6	Gene names	STON2, STN2, STNB
Domain Architecture
Description	Stonin-2 (Stoned B).

NCOA5_HUMAN
NC score	0.003752 (rank : 492)	θ value	8.99809 (rank : 445)
Query Neighborhood Hits	453	Target Neighborhood Hits	99	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HCD5, Q6HA99, Q9H1F2, Q9H2T2, Q9H4Y9	Gene names	NCOA5, KIAA1637
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA).

CATF_HUMAN
NC score	0.003343 (rank : 493)	θ value	5.27518 (rank : 410)
Query Neighborhood Hits	453	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UBX1, O95240, Q9NSU4, Q9UKQ5	Gene names	CTSF
Domain Architecture
Description	Cathepsin F precursor (EC 3.4.22.41) (CATSF).

NGN2_HUMAN
NC score	0.002450 (rank : 494)	θ value	3.0926 (rank : 392)
Query Neighborhood Hits	453	Target Neighborhood Hits	92	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H2A3, Q8N416	Gene names	NEUROG2, NGN2
Domain Architecture	No domain graphic available
Description	Neurogenin 2.

TLE2_HUMAN
NC score	0.001951 (rank : 495)	θ value	0.813845 (rank : 357)
Query Neighborhood Hits	453	Target Neighborhood Hits	321	Shared Neighborhood Hits	8
SwissProt Accessions	Q04725, Q8WVY0, Q9Y6S0	Gene names	TLE2
Domain Architecture
Description	Transducin-like enhancer protein 2 (ESG2).

LRP5_HUMAN
NC score	0.000744 (rank : 496)	θ value	5.27518 (rank : 416)
Query Neighborhood Hits	453	Target Neighborhood Hits	224	Shared Neighborhood Hits	8
SwissProt Accessions	O75197, Q96TD6, Q9UP66	Gene names	LRP5, LRP7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor.

LAP2_HUMAN
NC score	-0.001709 (rank : 497)	θ value	4.03905 (rank : 404)
Query Neighborhood Hits	453	Target Neighborhood Hits	499	Shared Neighborhood Hits	14
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

NKX24_HUMAN
NC score	-0.005918 (rank : 498)	θ value	8.99809 (rank : 447)
Query Neighborhood Hits	453	Target Neighborhood Hits	366	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H2Z4	Gene names	NKX2-4, NKX2D
Domain Architecture
Description	Homeobox protein Nkx-2.4 (Homeobox protein NKX2.4) (Homeobox protein NK-2 homolog D).

NKX24_MOUSE
NC score	-0.006851 (rank : 499)	θ value	8.99809 (rank : 448)
Query Neighborhood Hits	453	Target Neighborhood Hits	356	Shared Neighborhood Hits	6
SwissProt Accessions	Q9EQM3, Q9EQM4	Gene names	Nkx2-4, Nkx2d
Domain Architecture
Description	Homeobox protein Nkx-2.4 (Homeobox protein NKX2.4) (Homeobox protein NK-2 homolog D).

GLIS1_HUMAN
NC score	-0.012313 (rank : 500)	θ value	4.03905 (rank : 403)
Query Neighborhood Hits	453	Target Neighborhood Hits	748	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NBF1, Q8N9V9	Gene names	GLIS1
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS1 (GLI-similar 1).

SIP1_HUMAN
NC score	-0.012912 (rank : 501)	θ value	2.36792 (rank : 388)
Query Neighborhood Hits	453	Target Neighborhood Hits	832	Shared Neighborhood Hits	12
SwissProt Accessions	O60315, Q9UED1	Gene names	ZFHX1B, KIAA0569, SIP1, ZFX1B
Domain Architecture
Description	Zinc finger homeobox protein 1b (Smad-interacting protein 1) (SMADIP1).

ZN366_HUMAN
NC score	-0.013890 (rank : 502)	θ value	4.03905 (rank : 407)
Query Neighborhood Hits	453	Target Neighborhood Hits	732	Shared Neighborhood Hits	8
SwissProt Accessions	Q8N895, Q7RTV4	Gene names	ZNF366
Domain Architecture	No domain graphic available
Description	Zinc finger protein 366.

ZN692_MOUSE
NC score	-0.013901 (rank : 503)	θ value	8.99809 (rank : 453)
Query Neighborhood Hits	453	Target Neighborhood Hits	751	Shared Neighborhood Hits	12
SwissProt Accessions	Q3U381	Gene names	Znf692, Zfp692
Domain Architecture	No domain graphic available
Description	Zinc finger protein 692.

ZFP38_MOUSE
NC score	-0.013972 (rank : 504)	θ value	3.0926 (rank : 395)
Query Neighborhood Hits	453	Target Neighborhood Hits	768	Shared Neighborhood Hits	11
SwissProt Accessions	Q07231	Gene names	Znf38, Zfp-38, Zfp38, Zipro1
Domain Architecture
Description	Zinc finger protein 38 (Zfp-38) (CtFIN51) (Transcription factor RU49).