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Network neighborhood for query Sequence : CEND1_HUMAN

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CEND1_HUMAN
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CEND1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	284	Target Neighborhood Hits	284	Shared Neighborhood Hits	284
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CEND1_MOUSE
θ value	0 (rank : 2)	NC score	0.987894 (rank : 2)
Query Neighborhood Hits	284	Target Neighborhood Hits	260	Shared Neighborhood Hits	196
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CEND2_HUMAN
θ value	0 (rank : 3)	NC score	0.944651 (rank : 3)
Query Neighborhood Hits	284	Target Neighborhood Hits	166	Shared Neighborhood Hits	133
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

CEND3_HUMAN
θ value	0 (rank : 4)	NC score	0.937539 (rank : 5)
Query Neighborhood Hits	284	Target Neighborhood Hits	275	Shared Neighborhood Hits	144
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CEND3_MOUSE
θ value	0 (rank : 5)	NC score	0.939446 (rank : 4)
Query Neighborhood Hits	284	Target Neighborhood Hits	228	Shared Neighborhood Hits	145
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CENB2_HUMAN
θ value	8.36355e-22 (rank : 6)	NC score	0.515750 (rank : 26)
Query Neighborhood Hits	284	Target Neighborhood Hits	425	Shared Neighborhood Hits	99
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENG1_MOUSE
θ value	1.42661e-21 (rank : 7)	NC score	0.515152 (rank : 27)
Query Neighborhood Hits	284	Target Neighborhood Hits	531	Shared Neighborhood Hits	63
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

CENG1_HUMAN
θ value	2.43343e-21 (rank : 8)	NC score	0.509980 (rank : 33)
Query Neighborhood Hits	284	Target Neighborhood Hits	544	Shared Neighborhood Hits	64
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

CENG2_MOUSE
θ value	4.15078e-21 (rank : 9)	NC score	0.481050 (rank : 48)
Query Neighborhood Hits	284	Target Neighborhood Hits	463	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

CENG2_HUMAN
θ value	5.42112e-21 (rank : 10)	NC score	0.478556 (rank : 51)
Query Neighborhood Hits	284	Target Neighborhood Hits	471	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

CENG3_HUMAN
θ value	1.2077e-20 (rank : 11)	NC score	0.502827 (rank : 39)
Query Neighborhood Hits	284	Target Neighborhood Hits	455	Shared Neighborhood Hits	58
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_MOUSE
θ value	1.2077e-20 (rank : 12)	NC score	0.502222 (rank : 40)
Query Neighborhood Hits	284	Target Neighborhood Hits	467	Shared Neighborhood Hits	59
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENB5_HUMAN
θ value	1.5773e-20 (rank : 13)	NC score	0.518903 (rank : 23)
Query Neighborhood Hits	284	Target Neighborhood Hits	395	Shared Neighborhood Hits	98
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CENB1_HUMAN
θ value	1.92812e-18 (rank : 14)	NC score	0.518121 (rank : 24)
Query Neighborhood Hits	284	Target Neighborhood Hits	383	Shared Neighborhood Hits	96
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

DDEF2_MOUSE
θ value	5.60996e-18 (rank : 15)	NC score	0.490292 (rank : 43)
Query Neighborhood Hits	284	Target Neighborhood Hits	625	Shared Neighborhood Hits	74
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDFL1_MOUSE
θ value	9.56915e-18 (rank : 16)	NC score	0.511903 (rank : 30)
Query Neighborhood Hits	284	Target Neighborhood Hits	324	Shared Neighborhood Hits	59
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

DDEF2_HUMAN
θ value	1.63225e-17 (rank : 17)	NC score	0.494457 (rank : 41)
Query Neighborhood Hits	284	Target Neighborhood Hits	599	Shared Neighborhood Hits	75
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF1_MOUSE
θ value	1.058e-16 (rank : 18)	NC score	0.504700 (rank : 38)
Query Neighborhood Hits	284	Target Neighborhood Hits	592	Shared Neighborhood Hits	72
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

GIT2_MOUSE
θ value	8.95645e-16 (rank : 19)	NC score	0.473218 (rank : 53)
Query Neighborhood Hits	284	Target Neighborhood Hits	323	Shared Neighborhood Hits	47
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

DDFL1_HUMAN
θ value	3.40345e-15 (rank : 20)	NC score	0.534002 (rank : 17)
Query Neighborhood Hits	284	Target Neighborhood Hits	353	Shared Neighborhood Hits	65
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

GIT2_HUMAN
θ value	7.58209e-15 (rank : 21)	NC score	0.474312 (rank : 52)
Query Neighborhood Hits	284	Target Neighborhood Hits	381	Shared Neighborhood Hits	51
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

MYO9B_HUMAN
θ value	7.58209e-15 (rank : 22)	NC score	0.286858 (rank : 89)
Query Neighborhood Hits	284	Target Neighborhood Hits	641	Shared Neighborhood Hits	68
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

GIT1_HUMAN
θ value	1.29331e-14 (rank : 23)	NC score	0.464321 (rank : 62)
Query Neighborhood Hits	284	Target Neighborhood Hits	336	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

GIT1_MOUSE
θ value	1.29331e-14 (rank : 24)	NC score	0.462436 (rank : 66)
Query Neighborhood Hits	284	Target Neighborhood Hits	341	Shared Neighborhood Hits	47
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

SMAP1_MOUSE
θ value	4.91457e-14 (rank : 25)	NC score	0.585517 (rank : 9)
Query Neighborhood Hits	284	Target Neighborhood Hits	120	Shared Neighborhood Hits	41
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

MYO9B_MOUSE
θ value	6.41864e-14 (rank : 26)	NC score	0.289380 (rank : 88)
Query Neighborhood Hits	284	Target Neighborhood Hits	311	Shared Neighborhood Hits	62
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

GMIP_MOUSE
θ value	3.18553e-13 (rank : 27)	NC score	0.530594 (rank : 18)
Query Neighborhood Hits	284	Target Neighborhood Hits	202	Shared Neighborhood Hits	61
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

ABR_HUMAN
θ value	4.16044e-13 (rank : 28)	NC score	0.480966 (rank : 49)
Query Neighborhood Hits	284	Target Neighborhood Hits	166	Shared Neighborhood Hits	65
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

RHG05_MOUSE
θ value	4.16044e-13 (rank : 29)	NC score	0.509775 (rank : 34)
Query Neighborhood Hits	284	Target Neighborhood Hits	165	Shared Neighborhood Hits	57
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

SMAP1_HUMAN
θ value	4.16044e-13 (rank : 30)	NC score	0.582990 (rank : 10)
Query Neighborhood Hits	284	Target Neighborhood Hits	98	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IYB5, Q53H70, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4	Gene names	SMAP1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMP1L_MOUSE
θ value	4.16044e-13 (rank : 31)	NC score	0.586273 (rank : 7)
Query Neighborhood Hits	284	Target Neighborhood Hits	70	Shared Neighborhood Hits	39
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

SMP1L_HUMAN
θ value	5.43371e-13 (rank : 32)	NC score	0.586849 (rank : 6)
Query Neighborhood Hits	284	Target Neighborhood Hits	74	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

RHG05_HUMAN
θ value	9.26847e-13 (rank : 33)	NC score	0.506706 (rank : 37)
Query Neighborhood Hits	284	Target Neighborhood Hits	158	Shared Neighborhood Hits	56
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG04_HUMAN
θ value	4.59992e-12 (rank : 34)	NC score	0.459282 (rank : 67)
Query Neighborhood Hits	284	Target Neighborhood Hits	307	Shared Neighborhood Hits	59
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

CHIN_MOUSE
θ value	7.84624e-12 (rank : 35)	NC score	0.472029 (rank : 54)
Query Neighborhood Hits	284	Target Neighborhood Hits	229	Shared Neighborhood Hits	63
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

RBP1_HUMAN
θ value	1.33837e-11 (rank : 36)	NC score	0.471429 (rank : 56)
Query Neighborhood Hits	284	Target Neighborhood Hits	521	Shared Neighborhood Hits	74
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RBP1_MOUSE
θ value	1.74796e-11 (rank : 37)	NC score	0.481218 (rank : 47)
Query Neighborhood Hits	284	Target Neighborhood Hits	493	Shared Neighborhood Hits	74
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RHG09_HUMAN
θ value	2.28291e-11 (rank : 38)	NC score	0.550614 (rank : 12)
Query Neighborhood Hits	284	Target Neighborhood Hits	186	Shared Neighborhood Hits	63
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

CHIN_HUMAN
θ value	5.08577e-11 (rank : 39)	NC score	0.468611 (rank : 59)
Query Neighborhood Hits	284	Target Neighborhood Hits	227	Shared Neighborhood Hits	62
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

BCR_HUMAN
θ value	6.64225e-11 (rank : 40)	NC score	0.471490 (rank : 55)
Query Neighborhood Hits	284	Target Neighborhood Hits	204	Shared Neighborhood Hits	68
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

RHG06_HUMAN
θ value	6.64225e-11 (rank : 41)	NC score	0.514064 (rank : 28)
Query Neighborhood Hits	284	Target Neighborhood Hits	114	Shared Neighborhood Hits	57
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG06_MOUSE
θ value	6.64225e-11 (rank : 42)	NC score	0.513040 (rank : 29)
Query Neighborhood Hits	284	Target Neighborhood Hits	105	Shared Neighborhood Hits	57
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

CENA1_HUMAN
θ value	8.67504e-11 (rank : 43)	NC score	0.585741 (rank : 8)
Query Neighborhood Hits	284	Target Neighborhood Hits	87	Shared Neighborhood Hits	75
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

SRGP1_HUMAN
θ value	1.47974e-10 (rank : 44)	NC score	0.440696 (rank : 70)
Query Neighborhood Hits	284	Target Neighborhood Hits	390	Shared Neighborhood Hits	67
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
θ value	1.47974e-10 (rank : 45)	NC score	0.448928 (rank : 68)
Query Neighborhood Hits	284	Target Neighborhood Hits	331	Shared Neighborhood Hits	61
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

CHIO_HUMAN
θ value	1.9326e-10 (rank : 46)	NC score	0.467290 (rank : 60)
Query Neighborhood Hits	284	Target Neighborhood Hits	220	Shared Neighborhood Hits	62
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

GMIP_HUMAN
θ value	1.9326e-10 (rank : 47)	NC score	0.515791 (rank : 25)
Query Neighborhood Hits	284	Target Neighborhood Hits	225	Shared Neighborhood Hits	61
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

CHIO_MOUSE
θ value	3.29651e-10 (rank : 48)	NC score	0.487598 (rank : 44)
Query Neighborhood Hits	284	Target Neighborhood Hits	130	Shared Neighborhood Hits	57
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

RHG12_HUMAN
θ value	4.30538e-10 (rank : 49)	NC score	0.508949 (rank : 36)
Query Neighborhood Hits	284	Target Neighborhood Hits	190	Shared Neighborhood Hits	62
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	4.30538e-10 (rank : 50)	NC score	0.509231 (rank : 35)
Query Neighborhood Hits	284	Target Neighborhood Hits	204	Shared Neighborhood Hits	63
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

SRGP2_MOUSE
θ value	5.62301e-10 (rank : 51)	NC score	0.443543 (rank : 69)
Query Neighborhood Hits	284	Target Neighborhood Hits	324	Shared Neighborhood Hits	63
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

CENA2_HUMAN
θ value	9.59137e-10 (rank : 52)	NC score	0.554474 (rank : 11)
Query Neighborhood Hits	284	Target Neighborhood Hits	83	Shared Neighborhood Hits	68
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

FNBP2_HUMAN
θ value	9.59137e-10 (rank : 53)	NC score	0.440225 (rank : 71)
Query Neighborhood Hits	284	Target Neighborhood Hits	432	Shared Neighborhood Hits	66
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

OPHN1_MOUSE
θ value	2.13673e-09 (rank : 54)	NC score	0.536703 (rank : 14)
Query Neighborhood Hits	284	Target Neighborhood Hits	174	Shared Neighborhood Hits	66
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

RGAP1_HUMAN
θ value	2.13673e-09 (rank : 55)	NC score	0.521429 (rank : 22)
Query Neighborhood Hits	284	Target Neighborhood Hits	189	Shared Neighborhood Hits	61
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RGAP1_MOUSE
θ value	2.13673e-09 (rank : 56)	NC score	0.524491 (rank : 20)
Query Neighborhood Hits	284	Target Neighborhood Hits	185	Shared Neighborhood Hits	60
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

GRLF1_HUMAN
θ value	2.79066e-09 (rank : 57)	NC score	0.511332 (rank : 31)
Query Neighborhood Hits	284	Target Neighborhood Hits	167	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

TCGAP_HUMAN
θ value	2.79066e-09 (rank : 58)	NC score	0.439657 (rank : 72)
Query Neighborhood Hits	284	Target Neighborhood Hits	872	Shared Neighborhood Hits	73
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	2.79066e-09 (rank : 59)	NC score	0.482253 (rank : 46)
Query Neighborhood Hits	284	Target Neighborhood Hits	409	Shared Neighborhood Hits	63
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

CENA2_MOUSE
θ value	4.76016e-09 (rank : 60)	NC score	0.548719 (rank : 13)
Query Neighborhood Hits	284	Target Neighborhood Hits	68	Shared Neighborhood Hits	60
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

ARFG3_MOUSE
θ value	6.21693e-09 (rank : 61)	NC score	0.536609 (rank : 16)
Query Neighborhood Hits	284	Target Neighborhood Hits	80	Shared Neighborhood Hits	40
SwissProt Accessions	Q9D8S3, Q99KN8	Gene names	Arfgap3
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

OPHN1_HUMAN
θ value	8.11959e-09 (rank : 62)	NC score	0.527213 (rank : 19)
Query Neighborhood Hits	284	Target Neighborhood Hits	161	Shared Neighborhood Hits	62
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

TAGAP_HUMAN
θ value	8.11959e-09 (rank : 63)	NC score	0.471244 (rank : 57)
Query Neighborhood Hits	284	Target Neighborhood Hits	82	Shared Neighborhood Hits	53
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

ARFG3_HUMAN
θ value	1.80886e-08 (rank : 64)	NC score	0.536655 (rank : 15)
Query Neighborhood Hits	284	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

RHG01_HUMAN
θ value	5.26297e-08 (rank : 65)	NC score	0.462837 (rank : 63)
Query Neighborhood Hits	284	Target Neighborhood Hits	75	Shared Neighborhood Hits	56
SwissProt Accessions	Q07960	Gene names	ARHGAP1, CDC42GAP, RHOGAP1
Domain Architecture
Description	Rho-GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (CDC42 GTPase-activating protein) (p50-RhoGAP).

RHG26_HUMAN
θ value	8.97725e-08 (rank : 66)	NC score	0.493879 (rank : 42)
Query Neighborhood Hits	284	Target Neighborhood Hits	281	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RHG18_MOUSE
θ value	1.53129e-07 (rank : 67)	NC score	0.479565 (rank : 50)
Query Neighborhood Hits	284	Target Neighborhood Hits	110	Shared Neighborhood Hits	58
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

ARFG1_HUMAN
θ value	4.45536e-07 (rank : 68)	NC score	0.511110 (rank : 32)
Query Neighborhood Hits	284	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q8N6T3, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0	Gene names	ARFGAP1, ARF1GAP
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

ARFG1_MOUSE
θ value	5.81887e-07 (rank : 69)	NC score	0.524424 (rank : 21)
Query Neighborhood Hits	284	Target Neighborhood Hits	51	Shared Neighborhood Hits	39
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

RHG25_MOUSE
θ value	5.81887e-07 (rank : 70)	NC score	0.462756 (rank : 64)
Query Neighborhood Hits	284	Target Neighborhood Hits	492	Shared Neighborhood Hits	126
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG18_HUMAN
θ value	9.92553e-07 (rank : 71)	NC score	0.486114 (rank : 45)
Query Neighborhood Hits	284	Target Neighborhood Hits	90	Shared Neighborhood Hits	55
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

MYO10_HUMAN
θ value	1.29631e-06 (rank : 72)	NC score	0.098131 (rank : 123)
Query Neighborhood Hits	284	Target Neighborhood Hits	920	Shared Neighborhood Hits	93
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

PKHA1_MOUSE
θ value	1.29631e-06 (rank : 73)	NC score	0.277873 (rank : 91)
Query Neighborhood Hits	284	Target Neighborhood Hits	120	Shared Neighborhood Hits	69
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

TAGAP_MOUSE
θ value	1.69304e-06 (rank : 74)	NC score	0.462635 (rank : 65)
Query Neighborhood Hits	284	Target Neighborhood Hits	83	Shared Neighborhood Hits	55
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

PKHA1_HUMAN
θ value	2.21117e-06 (rank : 75)	NC score	0.281510 (rank : 90)
Query Neighborhood Hits	284	Target Neighborhood Hits	127	Shared Neighborhood Hits	72
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA6_HUMAN
θ value	2.88788e-06 (rank : 76)	NC score	0.229911 (rank : 97)
Query Neighborhood Hits	284	Target Neighborhood Hits	556	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

P85A_HUMAN
θ value	6.43352e-06 (rank : 77)	NC score	0.264315 (rank : 92)
Query Neighborhood Hits	284	Target Neighborhood Hits	479	Shared Neighborhood Hits	63
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

PKHA6_MOUSE
θ value	6.43352e-06 (rank : 78)	NC score	0.229404 (rank : 98)
Query Neighborhood Hits	284	Target Neighborhood Hits	591	Shared Neighborhood Hits	88
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

3BP1_HUMAN
θ value	1.43324e-05 (rank : 79)	NC score	0.466239 (rank : 61)
Query Neighborhood Hits	284	Target Neighborhood Hits	376	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

P85A_MOUSE
θ value	3.19293e-05 (rank : 80)	NC score	0.258518 (rank : 93)
Query Neighborhood Hits	284	Target Neighborhood Hits	435	Shared Neighborhood Hits	63
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

CE005_MOUSE
θ value	4.1701e-05 (rank : 81)	NC score	0.374991 (rank : 79)
Query Neighborhood Hits	284	Target Neighborhood Hits	238	Shared Neighborhood Hits	65
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

CE005_HUMAN
θ value	5.44631e-05 (rank : 82)	NC score	0.376478 (rank : 77)
Query Neighborhood Hits	284	Target Neighborhood Hits	213	Shared Neighborhood Hits	61
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

RAPH1_HUMAN
θ value	9.29e-05 (rank : 83)	NC score	0.085777 (rank : 139)
Query Neighborhood Hits	284	Target Neighborhood Hits	593	Shared Neighborhood Hits	36
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

RHG08_HUMAN
θ value	9.29e-05 (rank : 84)	NC score	0.434533 (rank : 74)
Query Neighborhood Hits	284	Target Neighborhood Hits	88	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NSG0, O75983, O95695, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NVX8, Q9NXL1, Q9UH20	Gene names	ARHGAP8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

RHG08_MOUSE
θ value	0.000158464 (rank : 85)	NC score	0.434586 (rank : 73)
Query Neighborhood Hits	284	Target Neighborhood Hits	73	Shared Neighborhood Hits	56
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

3BP1_MOUSE
θ value	0.00020696 (rank : 86)	NC score	0.469084 (rank : 58)
Query Neighborhood Hits	284	Target Neighborhood Hits	238	Shared Neighborhood Hits	67
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

EPHA4_HUMAN
θ value	0.00020696 (rank : 87)	NC score	0.062486 (rank : 180)
Query Neighborhood Hits	284	Target Neighborhood Hits	975	Shared Neighborhood Hits	41
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

NUPL_HUMAN
θ value	0.00020696 (rank : 88)	NC score	0.375709 (rank : 78)
Query Neighborhood Hits	284	Target Neighborhood Hits	68	Shared Neighborhood Hits	37
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).

NUPL_MOUSE
θ value	0.00020696 (rank : 89)	NC score	0.371947 (rank : 81)
Query Neighborhood Hits	284	Target Neighborhood Hits	113	Shared Neighborhood Hits	37
SwissProt Accessions	Q8K2K6, O70448, Q8BQL5, Q8CDK9	Gene names	Hrb, Rip
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein homolog).

EPHA1_HUMAN
θ value	0.000270298 (rank : 90)	NC score	0.060536 (rank : 185)
Query Neighborhood Hits	284	Target Neighborhood Hits	997	Shared Neighborhood Hits	40
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

PKHA5_HUMAN
θ value	0.000461057 (rank : 91)	NC score	0.162134 (rank : 101)
Query Neighborhood Hits	284	Target Neighborhood Hits	455	Shared Neighborhood Hits	90
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA2_MOUSE
θ value	0.00102713 (rank : 92)	NC score	0.236204 (rank : 96)
Query Neighborhood Hits	284	Target Neighborhood Hits	116	Shared Neighborhood Hits	69
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

EPHA4_MOUSE
θ value	0.00134147 (rank : 93)	NC score	0.060855 (rank : 184)
Query Neighborhood Hits	284	Target Neighborhood Hits	982	Shared Neighborhood Hits	42
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

GAB2_HUMAN
θ value	0.00134147 (rank : 94)	NC score	0.141663 (rank : 105)
Query Neighborhood Hits	284	Target Neighborhood Hits	188	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

WWP1_HUMAN
θ value	0.00175202 (rank : 95)	NC score	0.022717 (rank : 275)
Query Neighborhood Hits	284	Target Neighborhood Hits	262	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

EPHA1_MOUSE
θ value	0.00228821 (rank : 96)	NC score	0.062129 (rank : 181)
Query Neighborhood Hits	284	Target Neighborhood Hits	958	Shared Neighborhood Hits	40
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHA6_MOUSE
θ value	0.00228821 (rank : 97)	NC score	0.061985 (rank : 182)
Query Neighborhood Hits	284	Target Neighborhood Hits	946	Shared Neighborhood Hits	39
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

RHG07_MOUSE
θ value	0.00228821 (rank : 98)	NC score	0.377993 (rank : 76)
Query Neighborhood Hits	284	Target Neighborhood Hits	103	Shared Neighborhood Hits	58
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

AB1IP_MOUSE
θ value	0.00298849 (rank : 99)	NC score	0.098360 (rank : 122)
Query Neighborhood Hits	284	Target Neighborhood Hits	181	Shared Neighborhood Hits	29
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

RASA2_MOUSE
θ value	0.00298849 (rank : 100)	NC score	0.094411 (rank : 129)
Query Neighborhood Hits	284	Target Neighborhood Hits	159	Shared Neighborhood Hits	46
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

DGKH_HUMAN
θ value	0.00390308 (rank : 101)	NC score	0.137931 (rank : 107)
Query Neighborhood Hits	284	Target Neighborhood Hits	255	Shared Neighborhood Hits	93
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

EPHA6_HUMAN
θ value	0.00390308 (rank : 102)	NC score	0.063249 (rank : 177)
Query Neighborhood Hits	284	Target Neighborhood Hits	959	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

AB1IP_HUMAN
θ value	0.00509761 (rank : 103)	NC score	0.098530 (rank : 121)
Query Neighborhood Hits	284	Target Neighborhood Hits	213	Shared Neighborhood Hits	28
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

EPHA2_HUMAN
θ value	0.00509761 (rank : 104)	NC score	0.056209 (rank : 203)
Query Neighborhood Hits	284	Target Neighborhood Hits	1021	Shared Neighborhood Hits	43
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHA2_MOUSE
θ value	0.00509761 (rank : 105)	NC score	0.056744 (rank : 197)
Query Neighborhood Hits	284	Target Neighborhood Hits	1020	Shared Neighborhood Hits	43
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

GAB2_MOUSE
θ value	0.00509761 (rank : 106)	NC score	0.139509 (rank : 106)
Query Neighborhood Hits	284	Target Neighborhood Hits	220	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

RHG07_HUMAN
θ value	0.00509761 (rank : 107)	NC score	0.372462 (rank : 80)
Query Neighborhood Hits	284	Target Neighborhood Hits	108	Shared Neighborhood Hits	58
SwissProt Accessions	Q96QB1, O14868, O43199, Q9C0E0	Gene names	DLC1, ARHGAP7, KIAA1723, STARD12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

RASA3_HUMAN
θ value	0.00869519 (rank : 108)	NC score	0.097074 (rank : 125)
Query Neighborhood Hits	284	Target Neighborhood Hits	166	Shared Neighborhood Hits	46
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

RASA2_HUMAN
θ value	0.0113563 (rank : 109)	NC score	0.085957 (rank : 138)
Query Neighborhood Hits	284	Target Neighborhood Hits	157	Shared Neighborhood Hits	40
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

HRBL_HUMAN
θ value	0.0193708 (rank : 110)	NC score	0.322099 (rank : 84)
Query Neighborhood Hits	284	Target Neighborhood Hits	179	Shared Neighborhood Hits	38
SwissProt Accessions	O95081, O75429, Q96AB9, Q96GL4	Gene names	HRBL, RABR
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

HRBL_MOUSE
θ value	0.0193708 (rank : 111)	NC score	0.306400 (rank : 87)
Query Neighborhood Hits	284	Target Neighborhood Hits	269	Shared Neighborhood Hits	38
SwissProt Accessions	Q80WC7, Q8BKS5, Q99J67	Gene names	Hrbl, Rabr
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

C8AP2_HUMAN
θ value	0.0330416 (rank : 112)	NC score	0.031704 (rank : 264)
Query Neighborhood Hits	284	Target Neighborhood Hits	548	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UKL3, Q6PH76, Q7LCQ7, Q86YD9, Q9NUQ4, Q9NZV9, Q9P2N1, Q9Y563	Gene names	CASP8AP2, FLASH, KIAA1315, RIP25
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

EPHB2_HUMAN
θ value	0.0330416 (rank : 113)	NC score	0.055970 (rank : 204)
Query Neighborhood Hits	284	Target Neighborhood Hits	983	Shared Neighborhood Hits	40
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	0.0330416 (rank : 114)	NC score	0.055454 (rank : 211)
Query Neighborhood Hits	284	Target Neighborhood Hits	982	Shared Neighborhood Hits	40
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

OSBL9_HUMAN
θ value	0.0330416 (rank : 115)	NC score	0.087137 (rank : 136)
Query Neighborhood Hits	284	Target Neighborhood Hits	138	Shared Neighborhood Hits	56
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

PHLB2_MOUSE
θ value	0.0330416 (rank : 116)	NC score	0.065682 (rank : 172)
Query Neighborhood Hits	284	Target Neighborhood Hits	1016	Shared Neighborhood Hits	69
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PKHA2_HUMAN
θ value	0.0330416 (rank : 117)	NC score	0.211742 (rank : 99)
Query Neighborhood Hits	284	Target Neighborhood Hits	119	Shared Neighborhood Hits	73
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHA4_MOUSE
θ value	0.0330416 (rank : 118)	NC score	0.166705 (rank : 100)
Query Neighborhood Hits	284	Target Neighborhood Hits	202	Shared Neighborhood Hits	63
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

TNKS1_HUMAN
θ value	0.0330416 (rank : 119)	NC score	0.077275 (rank : 152)
Query Neighborhood Hits	284	Target Neighborhood Hits	477	Shared Neighborhood Hits	51
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

STA13_HUMAN
θ value	0.0431538 (rank : 120)	NC score	0.339933 (rank : 82)
Query Neighborhood Hits	284	Target Neighborhood Hits	89	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

STA13_MOUSE
θ value	0.0431538 (rank : 121)	NC score	0.336697 (rank : 83)
Query Neighborhood Hits	284	Target Neighborhood Hits	89	Shared Neighborhood Hits	53
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

MRIP_MOUSE
θ value	0.0563607 (rank : 122)	NC score	0.084429 (rank : 141)
Query Neighborhood Hits	284	Target Neighborhood Hits	569	Shared Neighborhood Hits	73
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

PKHA3_HUMAN
θ value	0.0563607 (rank : 123)	NC score	0.109331 (rank : 113)
Query Neighborhood Hits	284	Target Neighborhood Hits	66	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

SWP70_MOUSE
θ value	0.0563607 (rank : 124)	NC score	0.082805 (rank : 146)
Query Neighborhood Hits	284	Target Neighborhood Hits	1097	Shared Neighborhood Hits	91
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

EPHA7_HUMAN
θ value	0.0736092 (rank : 125)	NC score	0.056361 (rank : 199)
Query Neighborhood Hits	284	Target Neighborhood Hits	1053	Shared Neighborhood Hits	43
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA7_MOUSE
θ value	0.0736092 (rank : 126)	NC score	0.055750 (rank : 208)
Query Neighborhood Hits	284	Target Neighborhood Hits	1025	Shared Neighborhood Hits	40
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHB1_HUMAN
θ value	0.0736092 (rank : 127)	NC score	0.055713 (rank : 209)
Query Neighborhood Hits	284	Target Neighborhood Hits	988	Shared Neighborhood Hits	41
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

PKHA3_MOUSE
θ value	0.0736092 (rank : 128)	NC score	0.108974 (rank : 114)
Query Neighborhood Hits	284	Target Neighborhood Hits	67	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

SASH1_MOUSE
θ value	0.0736092 (rank : 129)	NC score	0.077073 (rank : 154)
Query Neighborhood Hits	284	Target Neighborhood Hits	263	Shared Neighborhood Hits	43
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

CYH1_MOUSE
θ value	0.0961366 (rank : 130)	NC score	0.104310 (rank : 116)
Query Neighborhood Hits	284	Target Neighborhood Hits	176	Shared Neighborhood Hits	80
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

FARP1_HUMAN
θ value	0.0961366 (rank : 131)	NC score	0.065917 (rank : 171)
Query Neighborhood Hits	284	Target Neighborhood Hits	241	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

PHLB2_HUMAN
θ value	0.0961366 (rank : 132)	NC score	0.063496 (rank : 175)
Query Neighborhood Hits	284	Target Neighborhood Hits	964	Shared Neighborhood Hits	63
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PKHA4_HUMAN
θ value	0.0961366 (rank : 133)	NC score	0.155245 (rank : 103)
Query Neighborhood Hits	284	Target Neighborhood Hits	283	Shared Neighborhood Hits	63
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

RAB13_HUMAN
θ value	0.0961366 (rank : 134)	NC score	0.023690 (rank : 273)
Query Neighborhood Hits	284	Target Neighborhood Hits	286	Shared Neighborhood Hits	20
SwissProt Accessions	P51153, Q96GU4	Gene names	RAB13
Domain Architecture
Description	Ras-related protein Rab-13.

CAC1B_MOUSE
θ value	0.125558 (rank : 135)	NC score	0.012735 (rank : 317)
Query Neighborhood Hits	284	Target Neighborhood Hits	351	Shared Neighborhood Hits	16
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

EPHB6_MOUSE
θ value	0.125558 (rank : 136)	NC score	0.068703 (rank : 165)
Query Neighborhood Hits	284	Target Neighborhood Hits	906	Shared Neighborhood Hits	40
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

OSBP2_HUMAN
θ value	0.125558 (rank : 137)	NC score	0.074534 (rank : 159)
Query Neighborhood Hits	284	Target Neighborhood Hits	154	Shared Neighborhood Hits	54
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

PHLB1_HUMAN
θ value	0.125558 (rank : 138)	NC score	0.062711 (rank : 179)
Query Neighborhood Hits	284	Target Neighborhood Hits	1038	Shared Neighborhood Hits	70
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PHLB1_MOUSE
θ value	0.125558 (rank : 139)	NC score	0.071842 (rank : 161)
Query Neighborhood Hits	284	Target Neighborhood Hits	678	Shared Neighborhood Hits	62
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

RAB13_MOUSE
θ value	0.125558 (rank : 140)	NC score	0.025310 (rank : 272)
Query Neighborhood Hits	284	Target Neighborhood Hits	289	Shared Neighborhood Hits	20
SwissProt Accessions	Q9DD03	Gene names	Rab13
Domain Architecture
Description	Ras-related protein Rab-13.

SWP70_HUMAN
θ value	0.125558 (rank : 141)	NC score	0.082836 (rank : 145)
Query Neighborhood Hits	284	Target Neighborhood Hits	973	Shared Neighborhood Hits	88
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

EPHA8_MOUSE
θ value	0.163984 (rank : 142)	NC score	0.059099 (rank : 190)
Query Neighborhood Hits	284	Target Neighborhood Hits	969	Shared Neighborhood Hits	41
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHB6_HUMAN
θ value	0.163984 (rank : 143)	NC score	0.069346 (rank : 163)
Query Neighborhood Hits	284	Target Neighborhood Hits	912	Shared Neighborhood Hits	41
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

SASH1_HUMAN
θ value	0.163984 (rank : 144)	NC score	0.077798 (rank : 150)
Query Neighborhood Hits	284	Target Neighborhood Hits	292	Shared Neighborhood Hits	43
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

CENPE_HUMAN
θ value	0.21417 (rank : 145)	NC score	0.018067 (rank : 286)
Query Neighborhood Hits	284	Target Neighborhood Hits	2060	Shared Neighborhood Hits	69
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

EPHA8_HUMAN
θ value	0.21417 (rank : 146)	NC score	0.057411 (rank : 194)
Query Neighborhood Hits	284	Target Neighborhood Hits	956	Shared Neighborhood Hits	41
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

POTE1_HUMAN
θ value	0.21417 (rank : 147)	NC score	0.029327 (rank : 267)
Query Neighborhood Hits	284	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NUX5, O95018, Q9H662, Q9NW19, Q9UG95	Gene names	POT1
Domain Architecture	No domain graphic available
Description	Protection of telomeres 1 (hPot1) (POT1-like telomere end-binding protein).

CLCN1_HUMAN
θ value	0.279714 (rank : 148)	NC score	0.023255 (rank : 274)
Query Neighborhood Hits	284	Target Neighborhood Hits	89	Shared Neighborhood Hits	5
SwissProt Accessions	P35523	Gene names	CLCN1, CLC1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

CYH1_HUMAN
θ value	0.279714 (rank : 149)	NC score	0.102850 (rank : 117)
Query Neighborhood Hits	284	Target Neighborhood Hits	184	Shared Neighborhood Hits	80
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

EPHA5_HUMAN
θ value	0.279714 (rank : 150)	NC score	0.056292 (rank : 202)
Query Neighborhood Hits	284	Target Neighborhood Hits	1009	Shared Neighborhood Hits	45
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

FGD4_MOUSE
θ value	0.279714 (rank : 151)	NC score	0.063088 (rank : 178)
Query Neighborhood Hits	284	Target Neighborhood Hits	227	Shared Neighborhood Hits	51
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

GAB1_HUMAN
θ value	0.279714 (rank : 152)	NC score	0.116747 (rank : 110)
Query Neighborhood Hits	284	Target Neighborhood Hits	279	Shared Neighborhood Hits	48
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

MTA3_HUMAN
θ value	0.279714 (rank : 153)	NC score	0.014761 (rank : 300)
Query Neighborhood Hits	284	Target Neighborhood Hits	37	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BTC8, Q9NSP2, Q9ULF4	Gene names	MTA3, KIAA1266
Domain Architecture
Description	Metastasis-associated protein MTA3.

DGKD_HUMAN
θ value	0.365318 (rank : 154)	NC score	0.111663 (rank : 111)
Query Neighborhood Hits	284	Target Neighborhood Hits	231	Shared Neighborhood Hits	69
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

EPHB3_HUMAN
θ value	0.365318 (rank : 155)	NC score	0.053788 (rank : 220)
Query Neighborhood Hits	284	Target Neighborhood Hits	996	Shared Neighborhood Hits	40
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

GAB1_MOUSE
θ value	0.365318 (rank : 156)	NC score	0.110588 (rank : 112)
Query Neighborhood Hits	284	Target Neighborhood Hits	233	Shared Neighborhood Hits	48
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

RASA3_MOUSE
θ value	0.365318 (rank : 157)	NC score	0.084189 (rank : 142)
Query Neighborhood Hits	284	Target Neighborhood Hits	144	Shared Neighborhood Hits	42
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

C43BP_MOUSE
θ value	0.47712 (rank : 158)	NC score	0.101630 (rank : 119)
Query Neighborhood Hits	284	Target Neighborhood Hits	91	Shared Neighborhood Hits	51
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

CSKI2_MOUSE
θ value	0.47712 (rank : 159)	NC score	0.087625 (rank : 135)
Query Neighborhood Hits	284	Target Neighborhood Hits	812	Shared Neighborhood Hits	79
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

TNKS2_HUMAN
θ value	0.47712 (rank : 160)	NC score	0.070237 (rank : 162)
Query Neighborhood Hits	284	Target Neighborhood Hits	361	Shared Neighborhood Hits	38
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

DGKK_HUMAN
θ value	0.62314 (rank : 161)	NC score	0.056991 (rank : 196)
Query Neighborhood Hits	284	Target Neighborhood Hits	378	Shared Neighborhood Hits	38
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

FGD1_HUMAN
θ value	0.62314 (rank : 162)	NC score	0.058577 (rank : 191)
Query Neighborhood Hits	284	Target Neighborhood Hits	367	Shared Neighborhood Hits	47
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	0.62314 (rank : 163)	NC score	0.056331 (rank : 201)
Query Neighborhood Hits	284	Target Neighborhood Hits	387	Shared Neighborhood Hits	44
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

MRIP_HUMAN
θ value	0.62314 (rank : 164)	NC score	0.076473 (rank : 155)
Query Neighborhood Hits	284	Target Neighborhood Hits	578	Shared Neighborhood Hits	71
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

OSBP1_HUMAN
θ value	0.62314 (rank : 165)	NC score	0.092972 (rank : 131)
Query Neighborhood Hits	284	Target Neighborhood Hits	180	Shared Neighborhood Hits	62
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

RAB8A_HUMAN
θ value	0.62314 (rank : 166)	NC score	0.014210 (rank : 305)
Query Neighborhood Hits	284	Target Neighborhood Hits	269	Shared Neighborhood Hits	15
SwissProt Accessions	P61006, P24407	Gene names	RAB8A, MEL, RAB8
Domain Architecture
Description	Ras-related protein Rab-8A (Oncogene c-mel).

RAB8A_MOUSE
θ value	0.62314 (rank : 167)	NC score	0.014255 (rank : 304)
Query Neighborhood Hits	284	Target Neighborhood Hits	269	Shared Neighborhood Hits	15
SwissProt Accessions	P55258, Q8VCF6	Gene names	Rab8a, Mel, Rab8
Domain Architecture
Description	Ras-related protein Rab-8A (Oncogene c-mel).

TARA_MOUSE
θ value	0.62314 (rank : 168)	NC score	0.054644 (rank : 217)
Query Neighborhood Hits	284	Target Neighborhood Hits	1133	Shared Neighborhood Hits	73
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

C43BP_HUMAN
θ value	0.813845 (rank : 169)	NC score	0.095132 (rank : 128)
Query Neighborhood Hits	284	Target Neighborhood Hits	87	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

CM007_HUMAN
θ value	0.813845 (rank : 170)	NC score	0.015787 (rank : 297)
Query Neighborhood Hits	284	Target Neighborhood Hits	422	Shared Neighborhood Hits	10
SwissProt Accessions	Q5W0B1, Q8TBY2, Q9H0T2, Q9H8M0	Gene names	C13orf7
Domain Architecture	No domain graphic available
Description	Protein C13orf7.

CSKI2_HUMAN
θ value	0.813845 (rank : 171)	NC score	0.086416 (rank : 137)
Query Neighborhood Hits	284	Target Neighborhood Hits	747	Shared Neighborhood Hits	75
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

OSBP2_MOUSE
θ value	0.813845 (rank : 172)	NC score	0.067399 (rank : 167)
Query Neighborhood Hits	284	Target Neighborhood Hits	150	Shared Neighborhood Hits	49
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

RAB8B_HUMAN
θ value	0.813845 (rank : 173)	NC score	0.012821 (rank : 315)
Query Neighborhood Hits	284	Target Neighborhood Hits	275	Shared Neighborhood Hits	15
SwissProt Accessions	Q92930, Q9P293	Gene names	RAB8B
Domain Architecture
Description	Ras-related protein Rab-8B.

RAB8B_MOUSE
θ value	0.813845 (rank : 174)	NC score	0.013034 (rank : 314)
Query Neighborhood Hits	284	Target Neighborhood Hits	277	Shared Neighborhood Hits	15
SwissProt Accessions	P61028, Q3U1Z3	Gene names	Rab8b
Domain Architecture
Description	Ras-related protein Rab-8B.

SAMN1_HUMAN
θ value	0.813845 (rank : 175)	NC score	0.048871 (rank : 247)
Query Neighborhood Hits	284	Target Neighborhood Hits	74	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

TEC_MOUSE
θ value	0.813845 (rank : 176)	NC score	0.036443 (rank : 259)
Query Neighborhood Hits	284	Target Neighborhood Hits	1006	Shared Neighborhood Hits	61
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

GCC2_HUMAN
θ value	1.06291 (rank : 177)	NC score	0.020585 (rank : 278)
Query Neighborhood Hits	284	Target Neighborhood Hits	1558	Shared Neighborhood Hits	59
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

KCNH7_MOUSE
θ value	1.06291 (rank : 178)	NC score	0.010772 (rank : 324)
Query Neighborhood Hits	284	Target Neighborhood Hits	98	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ER47	Gene names	Kcnh7, Erg3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (Ether-a-go-go-related protein 3) (Eag-related protein 3).

KIF1B_MOUSE
θ value	1.06291 (rank : 179)	NC score	0.014116 (rank : 306)
Query Neighborhood Hits	284	Target Neighborhood Hits	167	Shared Neighborhood Hits	23
SwissProt Accessions	Q60575, Q9R0B4, Q9WVE5, Q9Z119	Gene names	Kif1b
Domain Architecture
Description	Kinesin-like protein KIF1B.

RBP24_HUMAN
θ value	1.06291 (rank : 180)	NC score	0.020537 (rank : 279)
Query Neighborhood Hits	284	Target Neighborhood Hits	1559	Shared Neighborhood Hits	59
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

ATF2_MOUSE
θ value	1.38821 (rank : 181)	NC score	0.013625 (rank : 311)
Query Neighborhood Hits	284	Target Neighborhood Hits	397	Shared Neighborhood Hits	8
SwissProt Accessions	P16951, Q64089, Q64090, Q64091	Gene names	Atf2
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-2 (Activating transcription factor 2) (cAMP response element-binding protein CRE- BP1) (MXBP protein).

BRCA2_HUMAN
θ value	1.38821 (rank : 182)	NC score	0.015979 (rank : 295)
Query Neighborhood Hits	284	Target Neighborhood Hits	202	Shared Neighborhood Hits	9
SwissProt Accessions	P51587, O00183, O15008, Q13879	Gene names	BRCA2, FANCD1
Domain Architecture
Description	Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein).

CI084_HUMAN
θ value	1.38821 (rank : 183)	NC score	0.029195 (rank : 268)
Query Neighborhood Hits	284	Target Neighborhood Hits	40	Shared Neighborhood Hits	6
SwissProt Accessions	Q5VXU9, Q96M73	Gene names	C9orf84
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf84.

CYH2_HUMAN
θ value	1.38821 (rank : 184)	NC score	0.095726 (rank : 126)
Query Neighborhood Hits	284	Target Neighborhood Hits	175	Shared Neighborhood Hits	74
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	1.38821 (rank : 185)	NC score	0.095615 (rank : 127)
Query Neighborhood Hits	284	Target Neighborhood Hits	171	Shared Neighborhood Hits	74
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

EPHB3_MOUSE
θ value	1.38821 (rank : 186)	NC score	0.052716 (rank : 226)
Query Neighborhood Hits	284	Target Neighborhood Hits	996	Shared Neighborhood Hits	39
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

FLIP1_MOUSE
θ value	1.38821 (rank : 187)	NC score	0.014404 (rank : 302)
Query Neighborhood Hits	284	Target Neighborhood Hits	1176	Shared Neighborhood Hits	38
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

GRB14_MOUSE
θ value	1.38821 (rank : 188)	NC score	0.038590 (rank : 257)
Query Neighborhood Hits	284	Target Neighborhood Hits	149	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

ITK_HUMAN
θ value	1.38821 (rank : 189)	NC score	0.033432 (rank : 260)
Query Neighborhood Hits	284	Target Neighborhood Hits	1016	Shared Neighborhood Hits	62
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

KCNH7_HUMAN
θ value	1.38821 (rank : 190)	NC score	0.009955 (rank : 328)
Query Neighborhood Hits	284	Target Neighborhood Hits	107	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NS40	Gene names	KCNH7, ERG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (HERG-3) (Ether-a-go-go-related protein 3) (Eag- related protein 3).

RAI14_HUMAN
θ value	1.38821 (rank : 191)	NC score	0.058569 (rank : 192)
Query Neighborhood Hits	284	Target Neighborhood Hits	1367	Shared Neighborhood Hits	70
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

STAP2_MOUSE
θ value	1.38821 (rank : 192)	NC score	0.037260 (rank : 258)
Query Neighborhood Hits	284	Target Neighborhood Hits	41	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R0L1, Q8BWS2	Gene names	Stap2
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 2 (STAP-2).

TARA_HUMAN
θ value	1.38821 (rank : 193)	NC score	0.041963 (rank : 252)
Query Neighborhood Hits	284	Target Neighborhood Hits	1626	Shared Neighborhood Hits	78
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TXND2_MOUSE
θ value	1.38821 (rank : 194)	NC score	0.011188 (rank : 323)
Query Neighborhood Hits	284	Target Neighborhood Hits	828	Shared Neighborhood Hits	27
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

CYH3_HUMAN
θ value	1.81305 (rank : 195)	NC score	0.094104 (rank : 130)
Query Neighborhood Hits	284	Target Neighborhood Hits	137	Shared Neighborhood Hits	73
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

DNMT2_MOUSE
θ value	1.81305 (rank : 196)	NC score	0.018196 (rank : 285)
Query Neighborhood Hits	284	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	O55055, O35212	Gene names	Dnmt2, Met2
Domain Architecture
Description	tRNA (cytosine-5-)-methyltransferase (EC 2.1.1.29) (DNA (cytosine-5)- methyltransferase-like protein 2) (Dnmt2) (DNA methyltransferase homolog MmuIIP) (DNA MTase homolog MmuIIP) (M.MmuIIP) (Met-2).

EPHB4_MOUSE
θ value	1.81305 (rank : 197)	NC score	0.051694 (rank : 234)
Query Neighborhood Hits	284	Target Neighborhood Hits	1013	Shared Neighborhood Hits	41
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

FLIP1_HUMAN
θ value	1.81305 (rank : 198)	NC score	0.016617 (rank : 292)
Query Neighborhood Hits	284	Target Neighborhood Hits	1405	Shared Neighborhood Hits	44
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

GUC2G_MOUSE
θ value	1.81305 (rank : 199)	NC score	0.019407 (rank : 281)
Query Neighborhood Hits	284	Target Neighborhood Hits	644	Shared Neighborhood Hits	25
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

KIF1B_HUMAN
θ value	1.81305 (rank : 200)	NC score	0.014341 (rank : 303)
Query Neighborhood Hits	284	Target Neighborhood Hits	178	Shared Neighborhood Hits	26
SwissProt Accessions	O60333, Q96Q94, Q9BV80, Q9P280	Gene names	KIF1B, KIAA0591, KIAA1448
Domain Architecture
Description	Kinesin-like protein KIF1B (Klp).

PCLO_HUMAN
θ value	1.81305 (rank : 201)	NC score	0.031677 (rank : 265)
Query Neighborhood Hits	284	Target Neighborhood Hits	2046	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PLEK_HUMAN
θ value	1.81305 (rank : 202)	NC score	0.104542 (rank : 115)
Query Neighborhood Hits	284	Target Neighborhood Hits	110	Shared Neighborhood Hits	62
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

ZCH11_HUMAN
θ value	1.81305 (rank : 203)	NC score	0.012663 (rank : 318)
Query Neighborhood Hits	284	Target Neighborhood Hits	278	Shared Neighborhood Hits	8
SwissProt Accessions	Q5TAX3, Q12764, Q5TAX4, Q86XZ3	Gene names	ZCCHC11, KIAA0191
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 11.

COMDA_HUMAN
θ value	2.36792 (rank : 204)	NC score	0.018330 (rank : 283)
Query Neighborhood Hits	284	Target Neighborhood Hits	21	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y6G5, Q9P077	Gene names	COMMD10
Domain Architecture	No domain graphic available
Description	COMM domain-containing protein 10.

E41LA_MOUSE
θ value	2.36792 (rank : 205)	NC score	0.009944 (rank : 329)
Query Neighborhood Hits	284	Target Neighborhood Hits	85	Shared Neighborhood Hits	7
SwissProt Accessions	P52963	Gene names	Epb41l4a, Epb4.1l4, Epb4.1l4a, Epb41l4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

EPHB4_HUMAN
θ value	2.36792 (rank : 206)	NC score	0.051095 (rank : 238)
Query Neighborhood Hits	284	Target Neighborhood Hits	1056	Shared Neighborhood Hits	41
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

FARP2_MOUSE
θ value	2.36792 (rank : 207)	NC score	0.052219 (rank : 231)
Query Neighborhood Hits	284	Target Neighborhood Hits	209	Shared Neighborhood Hits	54
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FGD6_MOUSE
θ value	2.36792 (rank : 208)	NC score	0.052921 (rank : 224)
Query Neighborhood Hits	284	Target Neighborhood Hits	282	Shared Neighborhood Hits	51
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

M3K13_HUMAN
θ value	2.36792 (rank : 209)	NC score	0.016960 (rank : 291)
Query Neighborhood Hits	284	Target Neighborhood Hits	911	Shared Neighborhood Hits	32
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

OCRL_HUMAN
θ value	2.36792 (rank : 210)	NC score	0.159616 (rank : 102)
Query Neighborhood Hits	284	Target Neighborhood Hits	77	Shared Neighborhood Hits	47
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).

PKHF2_HUMAN
θ value	2.36792 (rank : 211)	NC score	0.032641 (rank : 262)
Query Neighborhood Hits	284	Target Neighborhood Hits	75	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	2.36792 (rank : 212)	NC score	0.033384 (rank : 261)
Query Neighborhood Hits	284	Target Neighborhood Hits	77	Shared Neighborhood Hits	23
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

SAMN1_MOUSE
θ value	2.36792 (rank : 213)	NC score	0.040328 (rank : 253)
Query Neighborhood Hits	284	Target Neighborhood Hits	69	Shared Neighborhood Hits	14
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

SMC1A_HUMAN
θ value	2.36792 (rank : 214)	NC score	0.018290 (rank : 284)
Query Neighborhood Hits	284	Target Neighborhood Hits	1346	Shared Neighborhood Hits	43
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

SMC1A_MOUSE
θ value	2.36792 (rank : 215)	NC score	0.018059 (rank : 287)
Query Neighborhood Hits	284	Target Neighborhood Hits	1384	Shared Neighborhood Hits	44
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

SMC4_MOUSE
θ value	2.36792 (rank : 216)	NC score	0.010644 (rank : 325)
Query Neighborhood Hits	284	Target Neighborhood Hits	830	Shared Neighborhood Hits	25
SwissProt Accessions	Q8CG47, Q8BTS7, Q8BTY9, Q99K21	Gene names	Smc4l1, Capc, Smc4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (XCAP-C homolog).

SYTL2_HUMAN
θ value	2.36792 (rank : 217)	NC score	0.013205 (rank : 312)
Query Neighborhood Hits	284	Target Neighborhood Hits	248	Shared Neighborhood Hits	15
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

ATF2_HUMAN
θ value	3.0926 (rank : 218)	NC score	0.011710 (rank : 321)
Query Neighborhood Hits	284	Target Neighborhood Hits	402	Shared Neighborhood Hits	8
SwissProt Accessions	P15336, Q13000	Gene names	ATF2, CREB2, CREBP1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-2 (Activating transcription factor 2) (cAMP response element-binding protein CRE- BP1) (HB16).

CYH4_MOUSE
θ value	3.0926 (rank : 219)	NC score	0.081183 (rank : 147)
Query Neighborhood Hits	284	Target Neighborhood Hits	134	Shared Neighborhood Hits	71
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

DDX51_HUMAN
θ value	3.0926 (rank : 220)	NC score	0.002962 (rank : 345)
Query Neighborhood Hits	284	Target Neighborhood Hits	332	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

FARP2_HUMAN
θ value	3.0926 (rank : 221)	NC score	0.055135 (rank : 214)
Query Neighborhood Hits	284	Target Neighborhood Hits	240	Shared Neighborhood Hits	48
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FGD5_MOUSE
θ value	3.0926 (rank : 222)	NC score	0.045279 (rank : 249)
Query Neighborhood Hits	284	Target Neighborhood Hits	170	Shared Neighborhood Hits	41
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FYB_MOUSE
θ value	3.0926 (rank : 223)	NC score	0.015926 (rank : 296)
Query Neighborhood Hits	284	Target Neighborhood Hits	194	Shared Neighborhood Hits	9
SwissProt Accessions	O35601, Q9Z2H3	Gene names	Fyb
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

GRB14_HUMAN
θ value	3.0926 (rank : 224)	NC score	0.041995 (rank : 251)
Query Neighborhood Hits	284	Target Neighborhood Hits	137	Shared Neighborhood Hits	23
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

MX1_HUMAN
θ value	3.0926 (rank : 225)	NC score	0.006613 (rank : 335)
Query Neighborhood Hits	284	Target Neighborhood Hits	62	Shared Neighborhood Hits	2
SwissProt Accessions	P20591	Gene names	MX1
Domain Architecture
Description	Interferon-induced GTP-binding protein Mx1 (Interferon-regulated resistance GTP-binding protein MxA) (Interferon-induced protein p78) (IFI-78K).

NEDD1_MOUSE
θ value	3.0926 (rank : 226)	NC score	0.004405 (rank : 343)
Query Neighborhood Hits	284	Target Neighborhood Hits	281	Shared Neighborhood Hits	3
SwissProt Accessions	P33215, Q6NXV3, Q8BN12, Q8BN86, Q8BQL9, Q9CWK2	Gene names	Nedd1, Nedd-1
Domain Architecture	No domain graphic available
Description	Protein NEDD1 (Neural precursor cell expressed developmentally down- regulated protein 1).

OSBL7_HUMAN
θ value	3.0926 (rank : 227)	NC score	0.031821 (rank : 263)
Query Neighborhood Hits	284	Target Neighborhood Hits	71	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BZF2	Gene names	OSBPL7, ORP7
Domain Architecture
Description	Oxysterol-binding protein-related protein 7 (OSBP-related protein 7) (ORP-7).

PKHB1_MOUSE
θ value	3.0926 (rank : 228)	NC score	0.055070 (rank : 215)
Query Neighborhood Hits	284	Target Neighborhood Hits	47	Shared Neighborhood Hits	29
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

RAB10_HUMAN
θ value	3.0926 (rank : 229)	NC score	0.013969 (rank : 307)
Query Neighborhood Hits	284	Target Neighborhood Hits	278	Shared Neighborhood Hits	18
SwissProt Accessions	P61026, O88386, Q6IA52, Q9D7X6, Q9H0T3	Gene names	RAB10
Domain Architecture
Description	Ras-related protein Rab-10.

RAB10_MOUSE
θ value	3.0926 (rank : 230)	NC score	0.013969 (rank : 308)
Query Neighborhood Hits	284	Target Neighborhood Hits	278	Shared Neighborhood Hits	18
SwissProt Accessions	P61027, O88386, Q9D7X6	Gene names	Rab10
Domain Architecture
Description	Ras-related protein Rab-10.

RB39A_HUMAN
θ value	3.0926 (rank : 231)	NC score	0.021219 (rank : 276)
Query Neighborhood Hits	284	Target Neighborhood Hits	276	Shared Neighborhood Hits	21
SwissProt Accessions	Q14964, Q8N6W2	Gene names	RAB39, RAB39A
Domain Architecture
Description	Ras-related protein Rab-39A (Rab-39).

AIRE_HUMAN
θ value	4.03905 (rank : 232)	NC score	0.005808 (rank : 340)
Query Neighborhood Hits	284	Target Neighborhood Hits	144	Shared Neighborhood Hits	4
SwissProt Accessions	O43918, O43922, O43932, O75745	Gene names	AIRE, APECED
Domain Architecture
Description	Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein).

CLCN1_MOUSE
θ value	4.03905 (rank : 233)	NC score	0.013888 (rank : 310)
Query Neighborhood Hits	284	Target Neighborhood Hits	61	Shared Neighborhood Hits	5
SwissProt Accessions	Q64347	Gene names	Clcn1, Clc1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

CYLC1_HUMAN
θ value	4.03905 (rank : 234)	NC score	0.013190 (rank : 313)
Query Neighborhood Hits	284	Target Neighborhood Hits	408	Shared Neighborhood Hits	15
SwissProt Accessions	P35663, Q5JQQ9	Gene names	CYLC1, CYL, CYL1
Domain Architecture	No domain graphic available
Description	Cylicin-1 (Cylicin I) (Multiple-band polypeptide I).

FCER2_MOUSE
θ value	4.03905 (rank : 235)	NC score	0.002666 (rank : 346)
Query Neighborhood Hits	284	Target Neighborhood Hits	392	Shared Neighborhood Hits	13
SwissProt Accessions	P20693, Q61556, Q61557	Gene names	Fcer2, Fcer2a
Domain Architecture
Description	Low affinity immunoglobulin epsilon Fc receptor (Lymphocyte IGE receptor) (Fc-epsilon-RII) (CD23 antigen).

GRB10_MOUSE
θ value	4.03905 (rank : 236)	NC score	0.039696 (rank : 256)
Query Neighborhood Hits	284	Target Neighborhood Hits	156	Shared Neighborhood Hits	23
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

IL17C_HUMAN
θ value	4.03905 (rank : 237)	NC score	0.016343 (rank : 294)
Query Neighborhood Hits	284	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P0M4, Q3MIG8, Q9HC75	Gene names	IL17C
Domain Architecture
Description	Interleukin-17C precursor (IL-17C) (Cytokine CX2).

PYRD_HUMAN
θ value	4.03905 (rank : 238)	NC score	0.012737 (rank : 316)
Query Neighborhood Hits	284	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q02127, Q6P176	Gene names	DHODH
Domain Architecture	No domain graphic available
Description	Dihydroorotate dehydrogenase, mitochondrial precursor (EC 1.3.3.1) (Dihydroorotate oxidase) (DHOdehase).

RB39B_HUMAN
θ value	4.03905 (rank : 239)	NC score	0.025732 (rank : 271)
Query Neighborhood Hits	284	Target Neighborhood Hits	279	Shared Neighborhood Hits	21
SwissProt Accessions	Q96DA2, Q5JT79, Q8NEX3	Gene names	RAB39B
Domain Architecture
Description	Ras-related protein Rab-39B.

RB39B_MOUSE
θ value	4.03905 (rank : 240)	NC score	0.025751 (rank : 270)
Query Neighborhood Hits	284	Target Neighborhood Hits	277	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BHC1, Q3TUJ3	Gene names	Rab39b
Domain Architecture
Description	Ras-related protein Rab-39B.

RIF1_HUMAN
θ value	4.03905 (rank : 241)	NC score	0.009975 (rank : 327)
Query Neighborhood Hits	284	Target Neighborhood Hits	320	Shared Neighborhood Hits	9
SwissProt Accessions	Q5UIP0, Q5H9R3, Q5UIP2, Q66YK6, Q6PRU2, Q8TE94, Q99772, Q9H830, Q9H9B9, Q9NVP5, Q9Y4R4	Gene names	RIF1
Domain Architecture	No domain graphic available
Description	Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog).

ALS2_HUMAN
θ value	5.27518 (rank : 242)	NC score	0.018598 (rank : 282)
Query Neighborhood Hits	284	Target Neighborhood Hits	121	Shared Neighborhood Hits	22
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

ALS2_MOUSE
θ value	5.27518 (rank : 243)	NC score	0.017891 (rank : 288)
Query Neighborhood Hits	284	Target Neighborhood Hits	111	Shared Neighborhood Hits	18
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

ANKS1_MOUSE
θ value	5.27518 (rank : 244)	NC score	0.055582 (rank : 210)
Query Neighborhood Hits	284	Target Neighborhood Hits	453	Shared Neighborhood Hits	61
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

ANLN_HUMAN
θ value	5.27518 (rank : 245)	NC score	0.039720 (rank : 255)
Query Neighborhood Hits	284	Target Neighborhood Hits	222	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NQW6, Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0	Gene names	ANLN
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

CNKR2_HUMAN
θ value	5.27518 (rank : 246)	NC score	0.075625 (rank : 157)
Query Neighborhood Hits	284	Target Neighborhood Hits	197	Shared Neighborhood Hits	63
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	5.27518 (rank : 247)	NC score	0.075861 (rank : 156)
Query Neighborhood Hits	284	Target Neighborhood Hits	197	Shared Neighborhood Hits	62
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CYH4_HUMAN
θ value	5.27518 (rank : 248)	NC score	0.078699 (rank : 149)
Query Neighborhood Hits	284	Target Neighborhood Hits	135	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

DAPP1_HUMAN
θ value	5.27518 (rank : 249)	NC score	0.122952 (rank : 109)
Query Neighborhood Hits	284	Target Neighborhood Hits	227	Shared Neighborhood Hits	73
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

EPHA5_MOUSE
θ value	5.27518 (rank : 250)	NC score	0.046106 (rank : 248)
Query Neighborhood Hits	284	Target Neighborhood Hits	950	Shared Neighborhood Hits	41
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

JHD2C_HUMAN
θ value	5.27518 (rank : 251)	NC score	0.005839 (rank : 339)
Query Neighborhood Hits	284	Target Neighborhood Hits	279	Shared Neighborhood Hits	14
SwissProt Accessions	Q15652, Q5SQZ8, Q5SQZ9, Q5SR00, Q7Z3E7, Q8N3U0, Q96KB9, Q9P2G7	Gene names	JMJD1C, JHDM2C, KIAA1380, TRIP8
Domain Architecture	No domain graphic available
Description	Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TRIP-8).

PKNX2_HUMAN
θ value	5.27518 (rank : 252)	NC score	0.006008 (rank : 338)
Query Neighborhood Hits	284	Target Neighborhood Hits	133	Shared Neighborhood Hits	4
SwissProt Accessions	Q96KN3, Q63HL6, Q86XD1	Gene names	PKNOX2, PREP2
Domain Architecture
Description	Homeobox protein PKNOX2 (PBX/knotted homeobox 2) (Homeobox protein PREP-2).

PKNX2_MOUSE
θ value	5.27518 (rank : 253)	NC score	0.005748 (rank : 341)
Query Neighborhood Hits	284	Target Neighborhood Hits	197	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BG99, Q8R4B0	Gene names	Pknox2, Prep2
Domain Architecture	No domain graphic available
Description	Homeobox protein PKNOX2 (PBX/knotted homeobox 2) (Homeobox protein PREP-2).

SOS2_HUMAN
θ value	5.27518 (rank : 254)	NC score	0.013898 (rank : 309)
Query Neighborhood Hits	284	Target Neighborhood Hits	193	Shared Neighborhood Hits	17
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

XPO7_HUMAN
θ value	5.27518 (rank : 255)	NC score	0.017860 (rank : 290)
Query Neighborhood Hits	284	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UIA9, O94846, Q6PJK9, Q8NEK7	Gene names	XPO7, KIAA0745, RANBP16
Domain Architecture
Description	Exportin-7 (Exp7) (Ran-binding protein 16).

XPO7_MOUSE
θ value	5.27518 (rank : 256)	NC score	0.017883 (rank : 289)
Query Neighborhood Hits	284	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EPK7, Q3TP94, Q80TS9, Q8BSK5, Q8C9M7, Q8CB42, Q8CBL8, Q8CEF5	Gene names	Xpo7, Kiaa0745, Ranbp16
Domain Architecture
Description	Exportin-7 (Exp7) (Ran-binding protein 16).

ALMS1_HUMAN
θ value	6.88961 (rank : 257)	NC score	0.006632 (rank : 334)
Query Neighborhood Hits	284	Target Neighborhood Hits	356	Shared Neighborhood Hits	10
SwissProt Accessions	Q8TCU4, Q53S05, Q580Q8, Q86VP9, Q9Y4G4	Gene names	ALMS1, KIAA0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1.

APS_MOUSE
θ value	6.88961 (rank : 258)	NC score	0.014564 (rank : 301)
Query Neighborhood Hits	284	Target Neighborhood Hits	134	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

CASC5_HUMAN
θ value	6.88961 (rank : 259)	NC score	0.010567 (rank : 326)
Query Neighborhood Hits	284	Target Neighborhood Hits	376	Shared Neighborhood Hits	18
SwissProt Accessions	Q8NG31, Q8NHE1, Q8WXA6, Q9HCK2, Q9NR92	Gene names	CASC5, KIAA1570
Domain Architecture	No domain graphic available
Description	Protein CASC5 (Cancer susceptibility candidate gene 5 protein) (ALL1- fused gene from chromosome 15q14) (AF15q14) (D40/AF15q14 protein).

CYH3_MOUSE
θ value	6.88961 (rank : 260)	NC score	0.087902 (rank : 134)
Query Neighborhood Hits	284	Target Neighborhood Hits	148	Shared Neighborhood Hits	77
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

DNJC1_MOUSE
θ value	6.88961 (rank : 261)	NC score	0.003315 (rank : 344)
Query Neighborhood Hits	284	Target Neighborhood Hits	129	Shared Neighborhood Hits	5
SwissProt Accessions	Q61712	Gene names	Dnajc1, Dnajl1, Mtj1
Domain Architecture
Description	DnaJ homolog subfamily C member 1 (DnaJ protein homolog MTJ1).

FGD4_HUMAN
θ value	6.88961 (rank : 262)	NC score	0.050841 (rank : 239)
Query Neighborhood Hits	284	Target Neighborhood Hits	219	Shared Neighborhood Hits	51
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

K0372_HUMAN
θ value	6.88961 (rank : 263)	NC score	0.007288 (rank : 332)
Query Neighborhood Hits	284	Target Neighborhood Hits	136	Shared Neighborhood Hits	5
SwissProt Accessions	Q6PGP7, O15077, Q6PJI3	Gene names	KIAA0372
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein KIAA0372 (TPR repeat protein KIAA0372).

PKHB1_HUMAN
θ value	6.88961 (rank : 264)	NC score	0.050401 (rank : 243)
Query Neighborhood Hits	284	Target Neighborhood Hits	46	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

PLEK_MOUSE
θ value	6.88961 (rank : 265)	NC score	0.088886 (rank : 133)
Query Neighborhood Hits	284	Target Neighborhood Hits	109	Shared Neighborhood Hits	55
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

STAP2_HUMAN
θ value	6.88961 (rank : 266)	NC score	0.021128 (rank : 277)
Query Neighborhood Hits	284	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UGK3, Q9NXI2	Gene names	STAP2, BKS
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 2 (STAP-2) (Breast tumor kinase substrate) (BRK substrate).

AKT1_HUMAN
θ value	8.99809 (rank : 267)	NC score	0.006866 (rank : 333)
Query Neighborhood Hits	284	Target Neighborhood Hits	885	Shared Neighborhood Hits	61
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

ALEX_MOUSE
θ value	8.99809 (rank : 268)	NC score	0.009300 (rank : 330)
Query Neighborhood Hits	284	Target Neighborhood Hits	197	Shared Neighborhood Hits	6
SwissProt Accessions	Q6R0H6, Q8BIR3	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

ANKS1_HUMAN
θ value	8.99809 (rank : 269)	NC score	0.050290 (rank : 245)
Query Neighborhood Hits	284	Target Neighborhood Hits	438	Shared Neighborhood Hits	59
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

ANLN_MOUSE
θ value	8.99809 (rank : 270)	NC score	0.043804 (rank : 250)
Query Neighborhood Hits	284	Target Neighborhood Hits	297	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

CEP35_HUMAN
θ value	8.99809 (rank : 271)	NC score	0.011921 (rank : 320)
Query Neighborhood Hits	284	Target Neighborhood Hits	811	Shared Neighborhood Hits	35
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

CEP70_MOUSE
θ value	8.99809 (rank : 272)	NC score	0.015669 (rank : 298)
Query Neighborhood Hits	284	Target Neighborhood Hits	532	Shared Neighborhood Hits	26
SwissProt Accessions	Q6IQY5, Q9CRL9, Q9CTS4, Q9JIC1	Gene names	Cep70
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 70 kDa (Cep70 protein).

DNL1_MOUSE
θ value	8.99809 (rank : 273)	NC score	0.006276 (rank : 337)
Query Neighborhood Hits	284	Target Neighborhood Hits	110	Shared Neighborhood Hits	8
SwissProt Accessions	P37913	Gene names	Lig1, Lig-1
Domain Architecture
Description	DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1).

HMGA2_HUMAN
θ value	8.99809 (rank : 274)	NC score	0.016500 (rank : 293)
Query Neighborhood Hits	284	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	P52926	Gene names	HMGA2, HMGIC
Domain Architecture	No domain graphic available
Description	High mobility group protein HMGI-C (High mobility group AT-hook protein 2).

HSP74_MOUSE
θ value	8.99809 (rank : 275)	NC score	0.004694 (rank : 342)
Query Neighborhood Hits	284	Target Neighborhood Hits	257	Shared Neighborhood Hits	16
SwissProt Accessions	Q61316	Gene names	Hspa4, Hsp110
Domain Architecture
Description	Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2).

LARP4_HUMAN
θ value	8.99809 (rank : 276)	NC score	0.006352 (rank : 336)
Query Neighborhood Hits	284	Target Neighborhood Hits	69	Shared Neighborhood Hits	4
SwissProt Accessions	Q71RC2, Q5CZ97, Q96NF9	Gene names	LARP4
Domain Architecture	No domain graphic available
Description	La-related protein 4 (La ribonucleoprotein domain family member 4).

OSBL1_MOUSE
θ value	8.99809 (rank : 277)	NC score	0.040230 (rank : 254)
Query Neighborhood Hits	284	Target Neighborhood Hits	336	Shared Neighborhood Hits	38
SwissProt Accessions	Q91XL9, O88318, Q3TH97, Q673L8, Q6DFU6	Gene names	Osbpl1a, Orp1, Orp1a
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

PDYN_HUMAN
θ value	8.99809 (rank : 278)	NC score	0.007717 (rank : 331)
Query Neighborhood Hits	284	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	P01213	Gene names	PDYN
Domain Architecture
Description	Beta-neoendorphin-dynorphin precursor (Proenkephalin B) (Preprodynorphin) [Contains: Beta-neoendorphin; Dynorphin; Leu- enkephalin; Rimorphin; Leumorphin].

PKHF1_MOUSE
θ value	8.99809 (rank : 279)	NC score	0.030733 (rank : 266)
Query Neighborhood Hits	284	Target Neighborhood Hits	80	Shared Neighborhood Hits	21
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

RB39A_MOUSE
θ value	8.99809 (rank : 280)	NC score	0.019469 (rank : 280)
Query Neighborhood Hits	284	Target Neighborhood Hits	279	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BHD0	Gene names	Rab39, Rab39a
Domain Architecture
Description	Ras-related protein Rab-39A (Rab-39).

SDCG8_MOUSE
θ value	8.99809 (rank : 281)	NC score	0.012119 (rank : 319)
Query Neighborhood Hits	284	Target Neighborhood Hits	886	Shared Neighborhood Hits	32
SwissProt Accessions	Q80UF4	Gene names	Sdccag8, Cccap
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (mCCCAP).

SLY_MOUSE
θ value	8.99809 (rank : 282)	NC score	0.026789 (rank : 269)
Query Neighborhood Hits	284	Target Neighborhood Hits	108	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SYCP1_MOUSE
θ value	8.99809 (rank : 283)	NC score	0.015149 (rank : 299)
Query Neighborhood Hits	284	Target Neighborhood Hits	1456	Shared Neighborhood Hits	54
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

SYTL4_HUMAN
θ value	8.99809 (rank : 284)	NC score	0.011281 (rank : 322)
Query Neighborhood Hits	284	Target Neighborhood Hits	138	Shared Neighborhood Hits	14
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

3BP2_HUMAN
θ value	θ > 10 (rank : 285)	NC score	0.077470 (rank : 151)
Query Neighborhood Hits	284	Target Neighborhood Hits	296	Shared Neighborhood Hits	47
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

3BP2_MOUSE
θ value	θ > 10 (rank : 286)	NC score	0.066428 (rank : 170)
Query Neighborhood Hits	284	Target Neighborhood Hits	142	Shared Neighborhood Hits	42
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

ANK1_HUMAN
θ value	θ > 10 (rank : 287)	NC score	0.050733 (rank : 240)
Query Neighborhood Hits	284	Target Neighborhood Hits	416	Shared Neighborhood Hits	27
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

ANK1_MOUSE
θ value	θ > 10 (rank : 288)	NC score	0.050655 (rank : 241)
Query Neighborhood Hits	284	Target Neighborhood Hits	430	Shared Neighborhood Hits	28
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

ANKR2_HUMAN
θ value	θ > 10 (rank : 289)	NC score	0.052996 (rank : 223)
Query Neighborhood Hits	284	Target Neighborhood Hits	321	Shared Neighborhood Hits	26
SwissProt Accessions	Q9GZV1, Q5T456, Q8WUD7	Gene names	ANKRD2, ARPP
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp).

ANKR6_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.051774 (rank : 232)
Query Neighborhood Hits	284	Target Neighborhood Hits	439	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y2G4, Q9NU24, Q9UFQ9	Gene names	ANKRD6, KIAA0957
Domain Architecture
Description	Ankyrin repeat domain-containing protein 6.

ANR10_HUMAN
θ value	θ > 10 (rank : 291)	NC score	0.052912 (rank : 225)
Query Neighborhood Hits	284	Target Neighborhood Hits	289	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NXR5	Gene names	ANKRD10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

ANR10_MOUSE
θ value	θ > 10 (rank : 292)	NC score	0.050424 (rank : 242)
Query Neighborhood Hits	284	Target Neighborhood Hits	273	Shared Neighborhood Hits	26
SwissProt Accessions	Q99LW0	Gene names	Ankrd10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

ANR37_HUMAN
θ value	θ > 10 (rank : 293)	NC score	0.059418 (rank : 189)
Query Neighborhood Hits	284	Target Neighborhood Hits	247	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z713	Gene names	ANKRD37, LPR2BP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37 (Low-density lipoprotein receptor-related protein 2-binding protein) (hLrp2bp).

ANR37_MOUSE
θ value	θ > 10 (rank : 294)	NC score	0.069254 (rank : 164)
Query Neighborhood Hits	284	Target Neighborhood Hits	237	Shared Neighborhood Hits	24
SwissProt Accessions	Q569N2, Q8CHS0	Gene names	Ankrd37
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37.

ANR39_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.063419 (rank : 176)
Query Neighborhood Hits	284	Target Neighborhood Hits	285	Shared Neighborhood Hits	26
SwissProt Accessions	Q53RE8, Q59FU2, Q8N5X5, Q9P0S5	Gene names	ANKRD39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ANR39_MOUSE
θ value	θ > 10 (rank : 296)	NC score	0.064698 (rank : 173)
Query Neighborhood Hits	284	Target Neighborhood Hits	284	Shared Neighborhood Hits	26
SwissProt Accessions	Q9D2X0	Gene names	Ankrd39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ANR41_HUMAN
θ value	θ > 10 (rank : 297)	NC score	0.073257 (rank : 160)
Query Neighborhood Hits	284	Target Neighborhood Hits	332	Shared Neighborhood Hits	27
SwissProt Accessions	Q8NAG6, Q8N8J8	Gene names	ANKRD41
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 41.

ANR42_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.051652 (rank : 235)
Query Neighborhood Hits	284	Target Neighborhood Hits	284	Shared Neighborhood Hits	26
SwissProt Accessions	Q8N9B4, Q49A49	Gene names	ANKRD42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

ANR46_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.068015 (rank : 166)
Query Neighborhood Hits	284	Target Neighborhood Hits	281	Shared Neighborhood Hits	25
SwissProt Accessions	Q86W74, Q6P9B7	Gene names	ANKRD46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

ANR46_MOUSE
θ value	θ > 10 (rank : 300)	NC score	0.067386 (rank : 168)
Query Neighborhood Hits	284	Target Neighborhood Hits	274	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BTZ5, Q1LZK9, Q8BV97	Gene names	Ankrd46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

ANS4B_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.055331 (rank : 212)
Query Neighborhood Hits	284	Target Neighborhood Hits	289	Shared Neighborhood Hits	24
SwissProt Accessions	Q8N8V4	Gene names	ANKS4B, HARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

ANS4B_MOUSE
θ value	θ > 10 (rank : 302)	NC score	0.060061 (rank : 186)
Query Neighborhood Hits	284	Target Neighborhood Hits	294	Shared Neighborhood Hits	24
SwissProt Accessions	Q8K3X6, Q9D8A5	Gene names	Anks4b, Harp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

ASB10_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.052422 (rank : 229)
Query Neighborhood Hits	284	Target Neighborhood Hits	291	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WXI3	Gene names	ASB10
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

ASB10_MOUSE
θ value	θ > 10 (rank : 304)	NC score	0.050289 (rank : 246)
Query Neighborhood Hits	284	Target Neighborhood Hits	301	Shared Neighborhood Hits	26
SwissProt Accessions	Q91ZT7	Gene names	Asb10
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

CDN2D_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.054270 (rank : 219)
Query Neighborhood Hits	284	Target Neighborhood Hits	268	Shared Neighborhood Hits	21
SwissProt Accessions	P55273, Q13102, Q6FGE9	Gene names	CDKN2D
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

CNKR1_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.083420 (rank : 143)
Query Neighborhood Hits	284	Target Neighborhood Hits	154	Shared Neighborhood Hits	52
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CSKI1_HUMAN
θ value	θ > 10 (rank : 307)	NC score	0.077086 (rank : 153)
Query Neighborhood Hits	284	Target Neighborhood Hits	997	Shared Neighborhood Hits	79
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI1_MOUSE
θ value	θ > 10 (rank : 308)	NC score	0.075185 (rank : 158)
Query Neighborhood Hits	284	Target Neighborhood Hits	1031	Shared Neighborhood Hits	76
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CT086_HUMAN
θ value	θ > 10 (rank : 309)	NC score	0.084688 (rank : 140)
Query Neighborhood Hits	284	Target Neighborhood Hits	277	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BZ19, Q4VXE6	Gene names	C20orf86
Domain Architecture
Description	Putative uncharacterized protein C20orf86.

DAPP1_MOUSE
θ value	θ > 10 (rank : 310)	NC score	0.126010 (rank : 108)
Query Neighborhood Hits	284	Target Neighborhood Hits	225	Shared Neighborhood Hits	73
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DP13A_HUMAN
θ value	θ > 10 (rank : 311)	NC score	0.102319 (rank : 118)
Query Neighborhood Hits	284	Target Neighborhood Hits	107	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13A_MOUSE
θ value	θ > 10 (rank : 312)	NC score	0.099316 (rank : 120)
Query Neighborhood Hits	284	Target Neighborhood Hits	96	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K3H0, Q3UJP7, Q69ZJ9, Q8BWZ8, Q8VCJ8, Q9CUW4	Gene names	Appl1, Dip13a, Kiaa1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13B_HUMAN
θ value	θ > 10 (rank : 313)	NC score	0.091077 (rank : 132)
Query Neighborhood Hits	284	Target Neighborhood Hits	58	Shared Neighborhood Hits	25
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

DP13B_MOUSE
θ value	θ > 10 (rank : 314)	NC score	0.097681 (rank : 124)
Query Neighborhood Hits	284	Target Neighborhood Hits	58	Shared Neighborhood Hits	19
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

EPHAA_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.056343 (rank : 200)
Query Neighborhood Hits	284	Target Neighborhood Hits	960	Shared Neighborhood Hits	39
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

FGD6_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.055855 (rank : 207)
Query Neighborhood Hits	284	Target Neighborhood Hits	237	Shared Neighborhood Hits	58
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

GABP2_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.059623 (rank : 187)
Query Neighborhood Hits	284	Target Neighborhood Hits	454	Shared Neighborhood Hits	29
SwissProt Accessions	Q06547, Q06545, Q12940, Q12941, Q12942, Q8IYD0	Gene names	GABPB2, E4TF1B, GABPB, GABPB1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1) (Transcription factor E4TF1-53) (Transcription factor E4TF1-47) (Nuclear respiratory factor 2).

GABP2_MOUSE
θ value	θ > 10 (rank : 318)	NC score	0.059466 (rank : 188)
Query Neighborhood Hits	284	Target Neighborhood Hits	429	Shared Neighborhood Hits	29
SwissProt Accessions	Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2	Gene names	Gabpb2, Gabpb, Gabpb1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1).

GABP3_MOUSE
θ value	θ > 10 (rank : 319)	NC score	0.061373 (rank : 183)
Query Neighborhood Hits	284	Target Neighborhood Hits	330	Shared Neighborhood Hits	28
SwissProt Accessions	P81069	Gene names	Gabpb2
Domain Architecture	No domain graphic available
Description	GA-binding protein beta-2-1 chain (GABP subunit beta-2-1) (GABPB2-1).

HECD1_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.057309 (rank : 195)
Query Neighborhood Hits	284	Target Neighborhood Hits	371	Shared Neighborhood Hits	30
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

I5P2_HUMAN
θ value	θ > 10 (rank : 321)	NC score	0.147613 (rank : 104)
Query Neighborhood Hits	284	Target Neighborhood Hits	86	Shared Neighborhood Hits	47
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

IASPP_MOUSE
θ value	θ > 10 (rank : 322)	NC score	0.055907 (rank : 205)
Query Neighborhood Hits	284	Target Neighborhood Hits	1024	Shared Neighborhood Hits	50
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IKBB_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.055282 (rank : 213)
Query Neighborhood Hits	284	Target Neighborhood Hits	284	Shared Neighborhood Hits	26
SwissProt Accessions	Q15653, Q96BJ7	Gene names	NFKBIB, IKBB, TRIP9
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9).

IKBB_MOUSE
θ value	θ > 10 (rank : 324)	NC score	0.063591 (rank : 174)
Query Neighborhood Hits	284	Target Neighborhood Hits	284	Shared Neighborhood Hits	26
SwissProt Accessions	Q60778, Q9D6L5	Gene names	Nfkbib, Ikbb
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B).

ILK1_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.052558 (rank : 227)
Query Neighborhood Hits	284	Target Neighborhood Hits	857	Shared Neighborhood Hits	54
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 326)	NC score	0.053584 (rank : 221)
Query Neighborhood Hits	284	Target Neighborhood Hits	848	Shared Neighborhood Hits	54
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 327)	NC score	0.051714 (rank : 233)
Query Neighborhood Hits	284	Target Neighborhood Hits	858	Shared Neighborhood Hits	54
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

K1688_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.240005 (rank : 95)
Query Neighborhood Hits	284	Target Neighborhood Hits	217	Shared Neighborhood Hits	57
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

K1688_MOUSE
θ value	θ > 10 (rank : 329)	NC score	0.247033 (rank : 94)
Query Neighborhood Hits	284	Target Neighborhood Hits	188	Shared Neighborhood Hits	59
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

MTMRD_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.054286 (rank : 218)
Query Neighborhood Hits	284	Target Neighborhood Hits	135	Shared Neighborhood Hits	52
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

MTPN_HUMAN
θ value	θ > 10 (rank : 331)	NC score	0.054966 (rank : 216)
Query Neighborhood Hits	284	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	P58546	Gene names	MTPN
Domain Architecture
Description	Myotrophin (Protein V-1).

MTPN_MOUSE
θ value	θ > 10 (rank : 332)	NC score	0.056379 (rank : 198)
Query Neighborhood Hits	284	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	P62774, P80144, Q543M6, Q9DCN8	Gene names	Mtpn, Gcdp
Domain Architecture	No domain graphic available
Description	Myotrophin (Protein V-1) (Granule cell differentiation protein).

MYPT1_HUMAN
θ value	θ > 10 (rank : 333)	NC score	0.052308 (rank : 230)
Query Neighborhood Hits	284	Target Neighborhood Hits	723	Shared Neighborhood Hits	43
SwissProt Accessions	O14974, Q86WU3, Q8NFR6, Q9BYH0	Gene names	PPP1R12A, MBS, MYPT1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit).

MYPT1_MOUSE
θ value	θ > 10 (rank : 334)	NC score	0.052445 (rank : 228)
Query Neighborhood Hits	284	Target Neighborhood Hits	539	Shared Neighborhood Hits	36
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

P85B_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.066546 (rank : 169)
Query Neighborhood Hits	284	Target Neighborhood Hits	543	Shared Neighborhood Hits	44
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 336)	NC score	0.053175 (rank : 222)
Query Neighborhood Hits	284	Target Neighborhood Hits	519	Shared Neighborhood Hits	42
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PKHB2_MOUSE
θ value	θ > 10 (rank : 337)	NC score	0.055885 (rank : 206)
Query Neighborhood Hits	284	Target Neighborhood Hits	48	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

PLEK2_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.083405 (rank : 144)
Query Neighborhood Hits	284	Target Neighborhood Hits	101	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_MOUSE
θ value	θ > 10 (rank : 339)	NC score	0.080072 (rank : 148)
Query Neighborhood Hits	284	Target Neighborhood Hits	96	Shared Neighborhood Hits	57
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PSD10_HUMAN
θ value	θ > 10 (rank : 340)	NC score	0.050366 (rank : 244)
Query Neighborhood Hits	284	Target Neighborhood Hits	301	Shared Neighborhood Hits	26
SwissProt Accessions	O75832	Gene names	PSMD10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

RASA1_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.057698 (rank : 193)
Query Neighborhood Hits	284	Target Neighborhood Hits	258	Shared Neighborhood Hits	51
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RHG25_HUMAN
θ value	θ > 10 (rank : 342)	NC score	0.414065 (rank : 75)
Query Neighborhood Hits	284	Target Neighborhood Hits	550	Shared Neighborhood Hits	124
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

STAR8_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.320593 (rank : 85)
Query Neighborhood Hits	284	Target Neighborhood Hits	216	Shared Neighborhood Hits	60
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STAR8_MOUSE
θ value	θ > 10 (rank : 344)	NC score	0.320435 (rank : 86)
Query Neighborhood Hits	284	Target Neighborhood Hits	101	Shared Neighborhood Hits	53
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

USH1G_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.051211 (rank : 237)
Query Neighborhood Hits	284	Target Neighborhood Hits	267	Shared Neighborhood Hits	26
SwissProt Accessions	Q495M9, Q8N251	Gene names	USH1G, SANS
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein (Scaffold protein containing ankyrin repeats and SAM domain).

USH1G_MOUSE
θ value	θ > 10 (rank : 346)	NC score	0.051421 (rank : 236)
Query Neighborhood Hits	284	Target Neighborhood Hits	271	Shared Neighborhood Hits	26
SwissProt Accessions	Q80T11, Q80UG0	Gene names	Ush1g, Sans
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein homolog (Scaffold protein containing ankyrin repeats and SAM domain) (Jackson shaker protein).

Hits sorted by NC score

CEND1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	284	Target Neighborhood Hits	284	Shared Neighborhood Hits	284
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CEND1_MOUSE
NC score	0.987894 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	284	Target Neighborhood Hits	260	Shared Neighborhood Hits	196
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CEND2_HUMAN
NC score	0.944651 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	284	Target Neighborhood Hits	166	Shared Neighborhood Hits	133
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

CEND3_MOUSE
NC score	0.939446 (rank : 4)	θ value	0 (rank : 5)
Query Neighborhood Hits	284	Target Neighborhood Hits	228	Shared Neighborhood Hits	145
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CEND3_HUMAN
NC score	0.937539 (rank : 5)	θ value	0 (rank : 4)
Query Neighborhood Hits	284	Target Neighborhood Hits	275	Shared Neighborhood Hits	144
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

SMP1L_HUMAN
NC score	0.586849 (rank : 6)	θ value	5.43371e-13 (rank : 32)
Query Neighborhood Hits	284	Target Neighborhood Hits	74	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

SMP1L_MOUSE
NC score	0.586273 (rank : 7)	θ value	4.16044e-13 (rank : 31)
Query Neighborhood Hits	284	Target Neighborhood Hits	70	Shared Neighborhood Hits	39
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

CENA1_HUMAN
NC score	0.585741 (rank : 8)	θ value	8.67504e-11 (rank : 43)
Query Neighborhood Hits	284	Target Neighborhood Hits	87	Shared Neighborhood Hits	75
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

SMAP1_MOUSE
NC score	0.585517 (rank : 9)	θ value	4.91457e-14 (rank : 25)
Query Neighborhood Hits	284	Target Neighborhood Hits	120	Shared Neighborhood Hits	41
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMAP1_HUMAN
NC score	0.582990 (rank : 10)	θ value	4.16044e-13 (rank : 30)
Query Neighborhood Hits	284	Target Neighborhood Hits	98	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IYB5, Q53H70, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4	Gene names	SMAP1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

CENA2_HUMAN
NC score	0.554474 (rank : 11)	θ value	9.59137e-10 (rank : 52)
Query Neighborhood Hits	284	Target Neighborhood Hits	83	Shared Neighborhood Hits	68
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

RHG09_HUMAN
NC score	0.550614 (rank : 12)	θ value	2.28291e-11 (rank : 38)
Query Neighborhood Hits	284	Target Neighborhood Hits	186	Shared Neighborhood Hits	63
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

CENA2_MOUSE
NC score	0.548719 (rank : 13)	θ value	4.76016e-09 (rank : 60)
Query Neighborhood Hits	284	Target Neighborhood Hits	68	Shared Neighborhood Hits	60
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

OPHN1_MOUSE
NC score	0.536703 (rank : 14)	θ value	2.13673e-09 (rank : 54)
Query Neighborhood Hits	284	Target Neighborhood Hits	174	Shared Neighborhood Hits	66
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

ARFG3_HUMAN
NC score	0.536655 (rank : 15)	θ value	1.80886e-08 (rank : 64)
Query Neighborhood Hits	284	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ARFG3_MOUSE
NC score	0.536609 (rank : 16)	θ value	6.21693e-09 (rank : 61)
Query Neighborhood Hits	284	Target Neighborhood Hits	80	Shared Neighborhood Hits	40
SwissProt Accessions	Q9D8S3, Q99KN8	Gene names	Arfgap3
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

DDFL1_HUMAN
NC score	0.534002 (rank : 17)	θ value	3.40345e-15 (rank : 20)
Query Neighborhood Hits	284	Target Neighborhood Hits	353	Shared Neighborhood Hits	65
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

GMIP_MOUSE
NC score	0.530594 (rank : 18)	θ value	3.18553e-13 (rank : 27)
Query Neighborhood Hits	284	Target Neighborhood Hits	202	Shared Neighborhood Hits	61
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

OPHN1_HUMAN
NC score	0.527213 (rank : 19)	θ value	8.11959e-09 (rank : 62)
Query Neighborhood Hits	284	Target Neighborhood Hits	161	Shared Neighborhood Hits	62
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

RGAP1_MOUSE
NC score	0.524491 (rank : 20)	θ value	2.13673e-09 (rank : 56)
Query Neighborhood Hits	284	Target Neighborhood Hits	185	Shared Neighborhood Hits	60
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

ARFG1_MOUSE
NC score	0.524424 (rank : 21)	θ value	5.81887e-07 (rank : 69)
Query Neighborhood Hits	284	Target Neighborhood Hits	51	Shared Neighborhood Hits	39
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

RGAP1_HUMAN
NC score	0.521429 (rank : 22)	θ value	2.13673e-09 (rank : 55)
Query Neighborhood Hits	284	Target Neighborhood Hits	189	Shared Neighborhood Hits	61
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

CENB5_HUMAN
NC score	0.518903 (rank : 23)	θ value	1.5773e-20 (rank : 13)
Query Neighborhood Hits	284	Target Neighborhood Hits	395	Shared Neighborhood Hits	98
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CENB1_HUMAN
NC score	0.518121 (rank : 24)	θ value	1.92812e-18 (rank : 14)
Query Neighborhood Hits	284	Target Neighborhood Hits	383	Shared Neighborhood Hits	96
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

GMIP_HUMAN
NC score	0.515791 (rank : 25)	θ value	1.9326e-10 (rank : 47)
Query Neighborhood Hits	284	Target Neighborhood Hits	225	Shared Neighborhood Hits	61
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

CENB2_HUMAN
NC score	0.515750 (rank : 26)	θ value	8.36355e-22 (rank : 6)
Query Neighborhood Hits	284	Target Neighborhood Hits	425	Shared Neighborhood Hits	99
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENG1_MOUSE
NC score	0.515152 (rank : 27)	θ value	1.42661e-21 (rank : 7)
Query Neighborhood Hits	284	Target Neighborhood Hits	531	Shared Neighborhood Hits	63
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

RHG06_HUMAN
NC score	0.514064 (rank : 28)	θ value	6.64225e-11 (rank : 41)
Query Neighborhood Hits	284	Target Neighborhood Hits	114	Shared Neighborhood Hits	57
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG06_MOUSE
NC score	0.513040 (rank : 29)	θ value	6.64225e-11 (rank : 42)
Query Neighborhood Hits	284	Target Neighborhood Hits	105	Shared Neighborhood Hits	57
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

DDFL1_MOUSE
NC score	0.511903 (rank : 30)	θ value	9.56915e-18 (rank : 16)
Query Neighborhood Hits	284	Target Neighborhood Hits	324	Shared Neighborhood Hits	59
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

GRLF1_HUMAN
NC score	0.511332 (rank : 31)	θ value	2.79066e-09 (rank : 57)
Query Neighborhood Hits	284	Target Neighborhood Hits	167	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

ARFG1_HUMAN
NC score	0.511110 (rank : 32)	θ value	4.45536e-07 (rank : 68)
Query Neighborhood Hits	284	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q8N6T3, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0	Gene names	ARFGAP1, ARF1GAP
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

CENG1_HUMAN
NC score	0.509980 (rank : 33)	θ value	2.43343e-21 (rank : 8)
Query Neighborhood Hits	284	Target Neighborhood Hits	544	Shared Neighborhood Hits	64
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

RHG05_MOUSE
NC score	0.509775 (rank : 34)	θ value	4.16044e-13 (rank : 29)
Query Neighborhood Hits	284	Target Neighborhood Hits	165	Shared Neighborhood Hits	57
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG12_MOUSE
NC score	0.509231 (rank : 35)	θ value	4.30538e-10 (rank : 50)
Query Neighborhood Hits	284	Target Neighborhood Hits	204	Shared Neighborhood Hits	63
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_HUMAN
NC score	0.508949 (rank : 36)	θ value	4.30538e-10 (rank : 49)
Query Neighborhood Hits	284	Target Neighborhood Hits	190	Shared Neighborhood Hits	62
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG05_HUMAN
NC score	0.506706 (rank : 37)	θ value	9.26847e-13 (rank : 33)
Query Neighborhood Hits	284	Target Neighborhood Hits	158	Shared Neighborhood Hits	56
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

DDEF1_MOUSE
NC score	0.504700 (rank : 38)	θ value	1.058e-16 (rank : 18)
Query Neighborhood Hits	284	Target Neighborhood Hits	592	Shared Neighborhood Hits	72
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

CENG3_HUMAN
NC score	0.502827 (rank : 39)	θ value	1.2077e-20 (rank : 11)
Query Neighborhood Hits	284	Target Neighborhood Hits	455	Shared Neighborhood Hits	58
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_MOUSE
NC score	0.502222 (rank : 40)	θ value	1.2077e-20 (rank : 12)
Query Neighborhood Hits	284	Target Neighborhood Hits	467	Shared Neighborhood Hits	59
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

DDEF2_HUMAN
NC score	0.494457 (rank : 41)	θ value	1.63225e-17 (rank : 17)
Query Neighborhood Hits	284	Target Neighborhood Hits	599	Shared Neighborhood Hits	75
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

RHG26_HUMAN
NC score	0.493879 (rank : 42)	θ value	8.97725e-08 (rank : 66)
Query Neighborhood Hits	284	Target Neighborhood Hits	281	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

DDEF2_MOUSE
NC score	0.490292 (rank : 43)	θ value	5.60996e-18 (rank : 15)
Query Neighborhood Hits	284	Target Neighborhood Hits	625	Shared Neighborhood Hits	74
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

CHIO_MOUSE
NC score	0.487598 (rank : 44)	θ value	3.29651e-10 (rank : 48)
Query Neighborhood Hits	284	Target Neighborhood Hits	130	Shared Neighborhood Hits	57
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

RHG18_HUMAN
NC score	0.486114 (rank : 45)	θ value	9.92553e-07 (rank : 71)
Query Neighborhood Hits	284	Target Neighborhood Hits	90	Shared Neighborhood Hits	55
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

TCGAP_MOUSE
NC score	0.482253 (rank : 46)	θ value	2.79066e-09 (rank : 59)
Query Neighborhood Hits	284	Target Neighborhood Hits	409	Shared Neighborhood Hits	63
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

RBP1_MOUSE
NC score	0.481218 (rank : 47)	θ value	1.74796e-11 (rank : 37)
Query Neighborhood Hits	284	Target Neighborhood Hits	493	Shared Neighborhood Hits	74
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

CENG2_MOUSE
NC score	0.481050 (rank : 48)	θ value	4.15078e-21 (rank : 9)
Query Neighborhood Hits	284	Target Neighborhood Hits	463	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

ABR_HUMAN
NC score	0.480966 (rank : 49)	θ value	4.16044e-13 (rank : 28)
Query Neighborhood Hits	284	Target Neighborhood Hits	166	Shared Neighborhood Hits	65
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

RHG18_MOUSE
NC score	0.479565 (rank : 50)	θ value	1.53129e-07 (rank : 67)
Query Neighborhood Hits	284	Target Neighborhood Hits	110	Shared Neighborhood Hits	58
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

CENG2_HUMAN
NC score	0.478556 (rank : 51)	θ value	5.42112e-21 (rank : 10)
Query Neighborhood Hits	284	Target Neighborhood Hits	471	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

GIT2_HUMAN
NC score	0.474312 (rank : 52)	θ value	7.58209e-15 (rank : 21)
Query Neighborhood Hits	284	Target Neighborhood Hits	381	Shared Neighborhood Hits	51
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

GIT2_MOUSE
NC score	0.473218 (rank : 53)	θ value	8.95645e-16 (rank : 19)
Query Neighborhood Hits	284	Target Neighborhood Hits	323	Shared Neighborhood Hits	47
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

CHIN_MOUSE
NC score	0.472029 (rank : 54)	θ value	7.84624e-12 (rank : 35)
Query Neighborhood Hits	284	Target Neighborhood Hits	229	Shared Neighborhood Hits	63
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

BCR_HUMAN
NC score	0.471490 (rank : 55)	θ value	6.64225e-11 (rank : 40)
Query Neighborhood Hits	284	Target Neighborhood Hits	204	Shared Neighborhood Hits	68
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

RBP1_HUMAN
NC score	0.471429 (rank : 56)	θ value	1.33837e-11 (rank : 36)
Query Neighborhood Hits	284	Target Neighborhood Hits	521	Shared Neighborhood Hits	74
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

TAGAP_HUMAN
NC score	0.471244 (rank : 57)	θ value	8.11959e-09 (rank : 63)
Query Neighborhood Hits	284	Target Neighborhood Hits	82	Shared Neighborhood Hits	53
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

3BP1_MOUSE
NC score	0.469084 (rank : 58)	θ value	0.00020696 (rank : 86)
Query Neighborhood Hits	284	Target Neighborhood Hits	238	Shared Neighborhood Hits	67
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

CHIN_HUMAN
NC score	0.468611 (rank : 59)	θ value	5.08577e-11 (rank : 39)
Query Neighborhood Hits	284	Target Neighborhood Hits	227	Shared Neighborhood Hits	62
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
NC score	0.467290 (rank : 60)	θ value	1.9326e-10 (rank : 46)
Query Neighborhood Hits	284	Target Neighborhood Hits	220	Shared Neighborhood Hits	62
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

3BP1_HUMAN
NC score	0.466239 (rank : 61)	θ value	1.43324e-05 (rank : 79)
Query Neighborhood Hits	284	Target Neighborhood Hits	376	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

GIT1_HUMAN
NC score	0.464321 (rank : 62)	θ value	1.29331e-14 (rank : 23)
Query Neighborhood Hits	284	Target Neighborhood Hits	336	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

RHG01_HUMAN
NC score	0.462837 (rank : 63)	θ value	5.26297e-08 (rank : 65)
Query Neighborhood Hits	284	Target Neighborhood Hits	75	Shared Neighborhood Hits	56
SwissProt Accessions	Q07960	Gene names	ARHGAP1, CDC42GAP, RHOGAP1
Domain Architecture
Description	Rho-GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (CDC42 GTPase-activating protein) (p50-RhoGAP).

RHG25_MOUSE
NC score	0.462756 (rank : 64)	θ value	5.81887e-07 (rank : 70)
Query Neighborhood Hits	284	Target Neighborhood Hits	492	Shared Neighborhood Hits	126
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

TAGAP_MOUSE
NC score	0.462635 (rank : 65)	θ value	1.69304e-06 (rank : 74)
Query Neighborhood Hits	284	Target Neighborhood Hits	83	Shared Neighborhood Hits	55
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

GIT1_MOUSE
NC score	0.462436 (rank : 66)	θ value	1.29331e-14 (rank : 24)
Query Neighborhood Hits	284	Target Neighborhood Hits	341	Shared Neighborhood Hits	47
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

RHG04_HUMAN
NC score	0.459282 (rank : 67)	θ value	4.59992e-12 (rank : 34)
Query Neighborhood Hits	284	Target Neighborhood Hits	307	Shared Neighborhood Hits	59
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

SRGP2_HUMAN
NC score	0.448928 (rank : 68)	θ value	1.47974e-10 (rank : 45)
Query Neighborhood Hits	284	Target Neighborhood Hits	331	Shared Neighborhood Hits	61
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
NC score	0.443543 (rank : 69)	θ value	5.62301e-10 (rank : 51)
Query Neighborhood Hits	284	Target Neighborhood Hits	324	Shared Neighborhood Hits	63
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRGP1_HUMAN
NC score	0.440696 (rank : 70)	θ value	1.47974e-10 (rank : 44)
Query Neighborhood Hits	284	Target Neighborhood Hits	390	Shared Neighborhood Hits	67
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

FNBP2_HUMAN
NC score	0.440225 (rank : 71)	θ value	9.59137e-10 (rank : 53)
Query Neighborhood Hits	284	Target Neighborhood Hits	432	Shared Neighborhood Hits	66
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

TCGAP_HUMAN
NC score	0.439657 (rank : 72)	θ value	2.79066e-09 (rank : 58)
Query Neighborhood Hits	284	Target Neighborhood Hits	872	Shared Neighborhood Hits	73
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

RHG08_MOUSE
NC score	0.434586 (rank : 73)	θ value	0.000158464 (rank : 85)
Query Neighborhood Hits	284	Target Neighborhood Hits	73	Shared Neighborhood Hits	56
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

RHG08_HUMAN
NC score	0.434533 (rank : 74)	θ value	9.29e-05 (rank : 84)
Query Neighborhood Hits	284	Target Neighborhood Hits	88	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NSG0, O75983, O95695, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NVX8, Q9NXL1, Q9UH20	Gene names	ARHGAP8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

RHG25_HUMAN
NC score	0.414065 (rank : 75)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	284	Target Neighborhood Hits	550	Shared Neighborhood Hits	124
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG07_MOUSE
NC score	0.377993 (rank : 76)	θ value	0.00228821 (rank : 98)
Query Neighborhood Hits	284	Target Neighborhood Hits	103	Shared Neighborhood Hits	58
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

CE005_HUMAN
NC score	0.376478 (rank : 77)	θ value	5.44631e-05 (rank : 82)
Query Neighborhood Hits	284	Target Neighborhood Hits	213	Shared Neighborhood Hits	61
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

NUPL_HUMAN
NC score	0.375709 (rank : 78)	θ value	0.00020696 (rank : 88)
Query Neighborhood Hits	284	Target Neighborhood Hits	68	Shared Neighborhood Hits	37
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).

CE005_MOUSE
NC score	0.374991 (rank : 79)	θ value	4.1701e-05 (rank : 81)
Query Neighborhood Hits	284	Target Neighborhood Hits	238	Shared Neighborhood Hits	65
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

RHG07_HUMAN
NC score	0.372462 (rank : 80)	θ value	0.00509761 (rank : 107)
Query Neighborhood Hits	284	Target Neighborhood Hits	108	Shared Neighborhood Hits	58
SwissProt Accessions	Q96QB1, O14868, O43199, Q9C0E0	Gene names	DLC1, ARHGAP7, KIAA1723, STARD12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

NUPL_MOUSE
NC score	0.371947 (rank : 81)	θ value	0.00020696 (rank : 89)
Query Neighborhood Hits	284	Target Neighborhood Hits	113	Shared Neighborhood Hits	37
SwissProt Accessions	Q8K2K6, O70448, Q8BQL5, Q8CDK9	Gene names	Hrb, Rip
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein homolog).

STA13_HUMAN
NC score	0.339933 (rank : 82)	θ value	0.0431538 (rank : 120)
Query Neighborhood Hits	284	Target Neighborhood Hits	89	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

STA13_MOUSE
NC score	0.336697 (rank : 83)	θ value	0.0431538 (rank : 121)
Query Neighborhood Hits	284	Target Neighborhood Hits	89	Shared Neighborhood Hits	53
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

HRBL_HUMAN
NC score	0.322099 (rank : 84)	θ value	0.0193708 (rank : 110)
Query Neighborhood Hits	284	Target Neighborhood Hits	179	Shared Neighborhood Hits	38
SwissProt Accessions	O95081, O75429, Q96AB9, Q96GL4	Gene names	HRBL, RABR
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

STAR8_HUMAN
NC score	0.320593 (rank : 85)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	284	Target Neighborhood Hits	216	Shared Neighborhood Hits	60
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STAR8_MOUSE
NC score	0.320435 (rank : 86)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	284	Target Neighborhood Hits	101	Shared Neighborhood Hits	53
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

HRBL_MOUSE
NC score	0.306400 (rank : 87)	θ value	0.0193708 (rank : 111)
Query Neighborhood Hits	284	Target Neighborhood Hits	269	Shared Neighborhood Hits	38
SwissProt Accessions	Q80WC7, Q8BKS5, Q99J67	Gene names	Hrbl, Rabr
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

MYO9B_MOUSE
NC score	0.289380 (rank : 88)	θ value	6.41864e-14 (rank : 26)
Query Neighborhood Hits	284	Target Neighborhood Hits	311	Shared Neighborhood Hits	62
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

MYO9B_HUMAN
NC score	0.286858 (rank : 89)	θ value	7.58209e-15 (rank : 22)
Query Neighborhood Hits	284	Target Neighborhood Hits	641	Shared Neighborhood Hits	68
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

PKHA1_HUMAN
NC score	0.281510 (rank : 90)	θ value	2.21117e-06 (rank : 75)
Query Neighborhood Hits	284	Target Neighborhood Hits	127	Shared Neighborhood Hits	72
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
NC score	0.277873 (rank : 91)	θ value	1.29631e-06 (rank : 73)
Query Neighborhood Hits	284	Target Neighborhood Hits	120	Shared Neighborhood Hits	69
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

P85A_HUMAN
NC score	0.264315 (rank : 92)	θ value	6.43352e-06 (rank : 77)
Query Neighborhood Hits	284	Target Neighborhood Hits	479	Shared Neighborhood Hits	63
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
NC score	0.258518 (rank : 93)	θ value	3.19293e-05 (rank : 80)
Query Neighborhood Hits	284	Target Neighborhood Hits	435	Shared Neighborhood Hits	63
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

K1688_MOUSE
NC score	0.247033 (rank : 94)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	284	Target Neighborhood Hits	188	Shared Neighborhood Hits	59
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

K1688_HUMAN
NC score	0.240005 (rank : 95)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	284	Target Neighborhood Hits	217	Shared Neighborhood Hits	57
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

PKHA2_MOUSE
NC score	0.236204 (rank : 96)	θ value	0.00102713 (rank : 92)
Query Neighborhood Hits	284	Target Neighborhood Hits	116	Shared Neighborhood Hits	69
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA6_HUMAN
NC score	0.229911 (rank : 97)	θ value	2.88788e-06 (rank : 76)
Query Neighborhood Hits	284	Target Neighborhood Hits	556	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
NC score	0.229404 (rank : 98)	θ value	6.43352e-06 (rank : 78)
Query Neighborhood Hits	284	Target Neighborhood Hits	591	Shared Neighborhood Hits	88
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA2_HUMAN
NC score	0.211742 (rank : 99)	θ value	0.0330416 (rank : 117)
Query Neighborhood Hits	284	Target Neighborhood Hits	119	Shared Neighborhood Hits	73
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHA4_MOUSE
NC score	0.166705 (rank : 100)	θ value	0.0330416 (rank : 118)
Query Neighborhood Hits	284	Target Neighborhood Hits	202	Shared Neighborhood Hits	63
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA5_HUMAN
NC score	0.162134 (rank : 101)	θ value	0.000461057 (rank : 91)
Query Neighborhood Hits	284	Target Neighborhood Hits	455	Shared Neighborhood Hits	90
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

OCRL_HUMAN
NC score	0.159616 (rank : 102)	θ value	2.36792 (rank : 210)
Query Neighborhood Hits	284	Target Neighborhood Hits	77	Shared Neighborhood Hits	47
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).

PKHA4_HUMAN
NC score	0.155245 (rank : 103)	θ value	0.0961366 (rank : 133)
Query Neighborhood Hits	284	Target Neighborhood Hits	283	Shared Neighborhood Hits	63
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

I5P2_HUMAN
NC score	0.147613 (rank : 104)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	284	Target Neighborhood Hits	86	Shared Neighborhood Hits	47
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

GAB2_HUMAN
NC score	0.141663 (rank : 105)	θ value	0.00134147 (rank : 94)
Query Neighborhood Hits	284	Target Neighborhood Hits	188	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

GAB2_MOUSE
NC score	0.139509 (rank : 106)	θ value	0.00509761 (rank : 106)
Query Neighborhood Hits	284	Target Neighborhood Hits	220	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

DGKH_HUMAN
NC score	0.137931 (rank : 107)	θ value	0.00390308 (rank : 101)
Query Neighborhood Hits	284	Target Neighborhood Hits	255	Shared Neighborhood Hits	93
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

DAPP1_MOUSE
NC score	0.126010 (rank : 108)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	284	Target Neighborhood Hits	225	Shared Neighborhood Hits	73
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_HUMAN
NC score	0.122952 (rank : 109)	θ value	5.27518 (rank : 249)
Query Neighborhood Hits	284	Target Neighborhood Hits	227	Shared Neighborhood Hits	73
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

GAB1_HUMAN
NC score	0.116747 (rank : 110)	θ value	0.279714 (rank : 152)
Query Neighborhood Hits	284	Target Neighborhood Hits	279	Shared Neighborhood Hits	48
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

DGKD_HUMAN
NC score	0.111663 (rank : 111)	θ value	0.365318 (rank : 154)
Query Neighborhood Hits	284	Target Neighborhood Hits	231	Shared Neighborhood Hits	69
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

GAB1_MOUSE
NC score	0.110588 (rank : 112)	θ value	0.365318 (rank : 156)
Query Neighborhood Hits	284	Target Neighborhood Hits	233	Shared Neighborhood Hits	48
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

PKHA3_HUMAN
NC score	0.109331 (rank : 113)	θ value	0.0563607 (rank : 123)
Query Neighborhood Hits	284	Target Neighborhood Hits	66	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PKHA3_MOUSE
NC score	0.108974 (rank : 114)	θ value	0.0736092 (rank : 128)
Query Neighborhood Hits	284	Target Neighborhood Hits	67	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PLEK_HUMAN
NC score	0.104542 (rank : 115)	θ value	1.81305 (rank : 202)
Query Neighborhood Hits	284	Target Neighborhood Hits	110	Shared Neighborhood Hits	62
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

CYH1_MOUSE
NC score	0.104310 (rank : 116)	θ value	0.0961366 (rank : 130)
Query Neighborhood Hits	284	Target Neighborhood Hits	176	Shared Neighborhood Hits	80
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

CYH1_HUMAN
NC score	0.102850 (rank : 117)	θ value	0.279714 (rank : 149)
Query Neighborhood Hits	284	Target Neighborhood Hits	184	Shared Neighborhood Hits	80
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

DP13A_HUMAN
NC score	0.102319 (rank : 118)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	284	Target Neighborhood Hits	107	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

C43BP_MOUSE
NC score	0.101630 (rank : 119)	θ value	0.47712 (rank : 158)
Query Neighborhood Hits	284	Target Neighborhood Hits	91	Shared Neighborhood Hits	51
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

DP13A_MOUSE
NC score	0.099316 (rank : 120)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	284	Target Neighborhood Hits	96	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K3H0, Q3UJP7, Q69ZJ9, Q8BWZ8, Q8VCJ8, Q9CUW4	Gene names	Appl1, Dip13a, Kiaa1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

AB1IP_HUMAN
NC score	0.098530 (rank : 121)	θ value	0.00509761 (rank : 103)
Query Neighborhood Hits	284	Target Neighborhood Hits	213	Shared Neighborhood Hits	28
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

AB1IP_MOUSE
NC score	0.098360 (rank : 122)	θ value	0.00298849 (rank : 99)
Query Neighborhood Hits	284	Target Neighborhood Hits	181	Shared Neighborhood Hits	29
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

MYO10_HUMAN
NC score	0.098131 (rank : 123)	θ value	1.29631e-06 (rank : 72)
Query Neighborhood Hits	284	Target Neighborhood Hits	920	Shared Neighborhood Hits	93
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

DP13B_MOUSE
NC score	0.097681 (rank : 124)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	284	Target Neighborhood Hits	58	Shared Neighborhood Hits	19
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

RASA3_HUMAN
NC score	0.097074 (rank : 125)	θ value	0.00869519 (rank : 108)
Query Neighborhood Hits	284	Target Neighborhood Hits	166	Shared Neighborhood Hits	46
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

CYH2_HUMAN
NC score	0.095726 (rank : 126)	θ value	1.38821 (rank : 184)
Query Neighborhood Hits	284	Target Neighborhood Hits	175	Shared Neighborhood Hits	74
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
NC score	0.095615 (rank : 127)	θ value	1.38821 (rank : 185)
Query Neighborhood Hits	284	Target Neighborhood Hits	171	Shared Neighborhood Hits	74
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

C43BP_HUMAN
NC score	0.095132 (rank : 128)	θ value	0.813845 (rank : 169)
Query Neighborhood Hits	284	Target Neighborhood Hits	87	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

RASA2_MOUSE
NC score	0.094411 (rank : 129)	θ value	0.00298849 (rank : 100)
Query Neighborhood Hits	284	Target Neighborhood Hits	159	Shared Neighborhood Hits	46
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

CYH3_HUMAN
NC score	0.094104 (rank : 130)	θ value	1.81305 (rank : 195)
Query Neighborhood Hits	284	Target Neighborhood Hits	137	Shared Neighborhood Hits	73
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

OSBP1_HUMAN
NC score	0.092972 (rank : 131)	θ value	0.62314 (rank : 165)
Query Neighborhood Hits	284	Target Neighborhood Hits	180	Shared Neighborhood Hits	62
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

DP13B_HUMAN
NC score	0.091077 (rank : 132)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	284	Target Neighborhood Hits	58	Shared Neighborhood Hits	25
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

PLEK_MOUSE
NC score	0.088886 (rank : 133)	θ value	6.88961 (rank : 265)
Query Neighborhood Hits	284	Target Neighborhood Hits	109	Shared Neighborhood Hits	55
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

CYH3_MOUSE
NC score	0.087902 (rank : 134)	θ value	6.88961 (rank : 260)
Query Neighborhood Hits	284	Target Neighborhood Hits	148	Shared Neighborhood Hits	77
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

CSKI2_MOUSE
NC score	0.087625 (rank : 135)	θ value	0.47712 (rank : 159)
Query Neighborhood Hits	284	Target Neighborhood Hits	812	Shared Neighborhood Hits	79
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

OSBL9_HUMAN
NC score	0.087137 (rank : 136)	θ value	0.0330416 (rank : 115)
Query Neighborhood Hits	284	Target Neighborhood Hits	138	Shared Neighborhood Hits	56
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

CSKI2_HUMAN
NC score	0.086416 (rank : 137)	θ value	0.813845 (rank : 171)
Query Neighborhood Hits	284	Target Neighborhood Hits	747	Shared Neighborhood Hits	75
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

RASA2_HUMAN
NC score	0.085957 (rank : 138)	θ value	0.0113563 (rank : 109)
Query Neighborhood Hits	284	Target Neighborhood Hits	157	Shared Neighborhood Hits	40
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RAPH1_HUMAN
NC score	0.085777 (rank : 139)	θ value	9.29e-05 (rank : 83)
Query Neighborhood Hits	284	Target Neighborhood Hits	593	Shared Neighborhood Hits	36
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

CT086_HUMAN
NC score	0.084688 (rank : 140)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	284	Target Neighborhood Hits	277	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BZ19, Q4VXE6	Gene names	C20orf86
Domain Architecture
Description	Putative uncharacterized protein C20orf86.

MRIP_MOUSE
NC score	0.084429 (rank : 141)	θ value	0.0563607 (rank : 122)
Query Neighborhood Hits	284	Target Neighborhood Hits	569	Shared Neighborhood Hits	73
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

RASA3_MOUSE
NC score	0.084189 (rank : 142)	θ value	0.365318 (rank : 157)
Query Neighborhood Hits	284	Target Neighborhood Hits	144	Shared Neighborhood Hits	42
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

CNKR1_HUMAN
NC score	0.083420 (rank : 143)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	284	Target Neighborhood Hits	154	Shared Neighborhood Hits	52
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

PLEK2_HUMAN
NC score	0.083405 (rank : 144)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	284	Target Neighborhood Hits	101	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

SWP70_HUMAN
NC score	0.082836 (rank : 145)	θ value	0.125558 (rank : 141)
Query Neighborhood Hits	284	Target Neighborhood Hits	973	Shared Neighborhood Hits	88
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
NC score	0.082805 (rank : 146)	θ value	0.0563607 (rank : 124)
Query Neighborhood Hits	284	Target Neighborhood Hits	1097	Shared Neighborhood Hits	91
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

CYH4_MOUSE
NC score	0.081183 (rank : 147)	θ value	3.0926 (rank : 219)
Query Neighborhood Hits	284	Target Neighborhood Hits	134	Shared Neighborhood Hits	71
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

PLEK2_MOUSE
NC score	0.080072 (rank : 148)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	284	Target Neighborhood Hits	96	Shared Neighborhood Hits	57
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

CYH4_HUMAN
NC score	0.078699 (rank : 149)	θ value	5.27518 (rank : 248)
Query Neighborhood Hits	284	Target Neighborhood Hits	135	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

SASH1_HUMAN
NC score	0.077798 (rank : 150)	θ value	0.163984 (rank : 144)
Query Neighborhood Hits	284	Target Neighborhood Hits	292	Shared Neighborhood Hits	43
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

3BP2_HUMAN
NC score	0.077470 (rank : 151)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	284	Target Neighborhood Hits	296	Shared Neighborhood Hits	47
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

TNKS1_HUMAN
NC score	0.077275 (rank : 152)	θ value	0.0330416 (rank : 119)
Query Neighborhood Hits	284	Target Neighborhood Hits	477	Shared Neighborhood Hits	51
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

CSKI1_HUMAN
NC score	0.077086 (rank : 153)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	284	Target Neighborhood Hits	997	Shared Neighborhood Hits	79
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

SASH1_MOUSE
NC score	0.077073 (rank : 154)	θ value	0.0736092 (rank : 129)
Query Neighborhood Hits	284	Target Neighborhood Hits	263	Shared Neighborhood Hits	43
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

MRIP_HUMAN
NC score	0.076473 (rank : 155)	θ value	0.62314 (rank : 164)
Query Neighborhood Hits	284	Target Neighborhood Hits	578	Shared Neighborhood Hits	71
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

CNKR2_MOUSE
NC score	0.075861 (rank : 156)	θ value	5.27518 (rank : 247)
Query Neighborhood Hits	284	Target Neighborhood Hits	197	Shared Neighborhood Hits	62
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.075625 (rank : 157)	θ value	5.27518 (rank : 246)
Query Neighborhood Hits	284	Target Neighborhood Hits	197	Shared Neighborhood Hits	63
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CSKI1_MOUSE
NC score	0.075185 (rank : 158)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	284	Target Neighborhood Hits	1031	Shared Neighborhood Hits	76
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

OSBP2_HUMAN
NC score	0.074534 (rank : 159)	θ value	0.125558 (rank : 137)
Query Neighborhood Hits	284	Target Neighborhood Hits	154	Shared Neighborhood Hits	54
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

ANR41_HUMAN
NC score	0.073257 (rank : 160)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	284	Target Neighborhood Hits	332	Shared Neighborhood Hits	27
SwissProt Accessions	Q8NAG6, Q8N8J8	Gene names	ANKRD41
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 41.

PHLB1_MOUSE
NC score	0.071842 (rank : 161)	θ value	0.125558 (rank : 139)
Query Neighborhood Hits	284	Target Neighborhood Hits	678	Shared Neighborhood Hits	62
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

TNKS2_HUMAN
NC score	0.070237 (rank : 162)	θ value	0.47712 (rank : 160)
Query Neighborhood Hits	284	Target Neighborhood Hits	361	Shared Neighborhood Hits	38
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

EPHB6_HUMAN
NC score	0.069346 (rank : 163)	θ value	0.163984 (rank : 143)
Query Neighborhood Hits	284	Target Neighborhood Hits	912	Shared Neighborhood Hits	41
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

ANR37_MOUSE
NC score	0.069254 (rank : 164)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	284	Target Neighborhood Hits	237	Shared Neighborhood Hits	24
SwissProt Accessions	Q569N2, Q8CHS0	Gene names	Ankrd37
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37.

EPHB6_MOUSE
NC score	0.068703 (rank : 165)	θ value	0.125558 (rank : 136)
Query Neighborhood Hits	284	Target Neighborhood Hits	906	Shared Neighborhood Hits	40
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

ANR46_HUMAN
NC score	0.068015 (rank : 166)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	284	Target Neighborhood Hits	281	Shared Neighborhood Hits	25
SwissProt Accessions	Q86W74, Q6P9B7	Gene names	ANKRD46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

OSBP2_MOUSE
NC score	0.067399 (rank : 167)	θ value	0.813845 (rank : 172)
Query Neighborhood Hits	284	Target Neighborhood Hits	150	Shared Neighborhood Hits	49
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

ANR46_MOUSE
NC score	0.067386 (rank : 168)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	284	Target Neighborhood Hits	274	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BTZ5, Q1LZK9, Q8BV97	Gene names	Ankrd46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

P85B_HUMAN
NC score	0.066546 (rank : 169)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	284	Target Neighborhood Hits	543	Shared Neighborhood Hits	44
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

3BP2_MOUSE
NC score	0.066428 (rank : 170)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	284	Target Neighborhood Hits	142	Shared Neighborhood Hits	42
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

FARP1_HUMAN
NC score	0.065917 (rank : 171)	θ value	0.0961366 (rank : 131)
Query Neighborhood Hits	284	Target Neighborhood Hits	241	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

PHLB2_MOUSE
NC score	0.065682 (rank : 172)	θ value	0.0330416 (rank : 116)
Query Neighborhood Hits	284	Target Neighborhood Hits	1016	Shared Neighborhood Hits	69
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

ANR39_MOUSE
NC score	0.064698 (rank : 173)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	284	Target Neighborhood Hits	284	Shared Neighborhood Hits	26
SwissProt Accessions	Q9D2X0	Gene names	Ankrd39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

IKBB_MOUSE
NC score	0.063591 (rank : 174)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	284	Target Neighborhood Hits	284	Shared Neighborhood Hits	26
SwissProt Accessions	Q60778, Q9D6L5	Gene names	Nfkbib, Ikbb
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B).

PHLB2_HUMAN
NC score	0.063496 (rank : 175)	θ value	0.0961366 (rank : 132)
Query Neighborhood Hits	284	Target Neighborhood Hits	964	Shared Neighborhood Hits	63
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

ANR39_HUMAN
NC score	0.063419 (rank : 176)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	284	Target Neighborhood Hits	285	Shared Neighborhood Hits	26
SwissProt Accessions	Q53RE8, Q59FU2, Q8N5X5, Q9P0S5	Gene names	ANKRD39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

EPHA6_HUMAN
NC score	0.063249 (rank : 177)	θ value	0.00390308 (rank : 102)
Query Neighborhood Hits	284	Target Neighborhood Hits	959	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

FGD4_MOUSE
NC score	0.063088 (rank : 178)	θ value	0.279714 (rank : 151)
Query Neighborhood Hits	284	Target Neighborhood Hits	227	Shared Neighborhood Hits	51
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

PHLB1_HUMAN
NC score	0.062711 (rank : 179)	θ value	0.125558 (rank : 138)
Query Neighborhood Hits	284	Target Neighborhood Hits	1038	Shared Neighborhood Hits	70
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

EPHA4_HUMAN
NC score	0.062486 (rank : 180)	θ value	0.00020696 (rank : 87)
Query Neighborhood Hits	284	Target Neighborhood Hits	975	Shared Neighborhood Hits	41
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA1_MOUSE
NC score	0.062129 (rank : 181)	θ value	0.00228821 (rank : 96)
Query Neighborhood Hits	284	Target Neighborhood Hits	958	Shared Neighborhood Hits	40
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHA6_MOUSE
NC score	0.061985 (rank : 182)	θ value	0.00228821 (rank : 97)
Query Neighborhood Hits	284	Target Neighborhood Hits	946	Shared Neighborhood Hits	39
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

GABP3_MOUSE
NC score	0.061373 (rank : 183)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	284	Target Neighborhood Hits	330	Shared Neighborhood Hits	28
SwissProt Accessions	P81069	Gene names	Gabpb2
Domain Architecture	No domain graphic available
Description	GA-binding protein beta-2-1 chain (GABP subunit beta-2-1) (GABPB2-1).

EPHA4_MOUSE
NC score	0.060855 (rank : 184)	θ value	0.00134147 (rank : 93)
Query Neighborhood Hits	284	Target Neighborhood Hits	982	Shared Neighborhood Hits	42
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA1_HUMAN
NC score	0.060536 (rank : 185)	θ value	0.000270298 (rank : 90)
Query Neighborhood Hits	284	Target Neighborhood Hits	997	Shared Neighborhood Hits	40
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

ANS4B_MOUSE
NC score	0.060061 (rank : 186)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	284	Target Neighborhood Hits	294	Shared Neighborhood Hits	24
SwissProt Accessions	Q8K3X6, Q9D8A5	Gene names	Anks4b, Harp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

GABP2_HUMAN
NC score	0.059623 (rank : 187)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	284	Target Neighborhood Hits	454	Shared Neighborhood Hits	29
SwissProt Accessions	Q06547, Q06545, Q12940, Q12941, Q12942, Q8IYD0	Gene names	GABPB2, E4TF1B, GABPB, GABPB1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1) (Transcription factor E4TF1-53) (Transcription factor E4TF1-47) (Nuclear respiratory factor 2).

GABP2_MOUSE
NC score	0.059466 (rank : 188)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	284	Target Neighborhood Hits	429	Shared Neighborhood Hits	29
SwissProt Accessions	Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2	Gene names	Gabpb2, Gabpb, Gabpb1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1).

ANR37_HUMAN
NC score	0.059418 (rank : 189)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	284	Target Neighborhood Hits	247	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z713	Gene names	ANKRD37, LPR2BP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37 (Low-density lipoprotein receptor-related protein 2-binding protein) (hLrp2bp).

EPHA8_MOUSE
NC score	0.059099 (rank : 190)	θ value	0.163984 (rank : 142)
Query Neighborhood Hits	284	Target Neighborhood Hits	969	Shared Neighborhood Hits	41
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

FGD1_HUMAN
NC score	0.058577 (rank : 191)	θ value	0.62314 (rank : 162)
Query Neighborhood Hits	284	Target Neighborhood Hits	367	Shared Neighborhood Hits	47
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

RAI14_HUMAN
NC score	0.058569 (rank : 192)	θ value	1.38821 (rank : 191)
Query Neighborhood Hits	284	Target Neighborhood Hits	1367	Shared Neighborhood Hits	70
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

RASA1_HUMAN
NC score	0.057698 (rank : 193)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	284	Target Neighborhood Hits	258	Shared Neighborhood Hits	51
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

EPHA8_HUMAN
NC score	0.057411 (rank : 194)	θ value	0.21417 (rank : 146)
Query Neighborhood Hits	284	Target Neighborhood Hits	956	Shared Neighborhood Hits	41
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

HECD1_HUMAN
NC score	0.057309 (rank : 195)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	284	Target Neighborhood Hits	371	Shared Neighborhood Hits	30
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

DGKK_HUMAN
NC score	0.056991 (rank : 196)	θ value	0.62314 (rank : 161)
Query Neighborhood Hits	284	Target Neighborhood Hits	378	Shared Neighborhood Hits	38
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

EPHA2_MOUSE
NC score	0.056744 (rank : 197)	θ value	0.00509761 (rank : 105)
Query Neighborhood Hits	284	Target Neighborhood Hits	1020	Shared Neighborhood Hits	43
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

MTPN_MOUSE
NC score	0.056379 (rank : 198)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	284	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	P62774, P80144, Q543M6, Q9DCN8	Gene names	Mtpn, Gcdp
Domain Architecture	No domain graphic available
Description	Myotrophin (Protein V-1) (Granule cell differentiation protein).

EPHA7_HUMAN
NC score	0.056361 (rank : 199)	θ value	0.0736092 (rank : 125)
Query Neighborhood Hits	284	Target Neighborhood Hits	1053	Shared Neighborhood Hits	43
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHAA_HUMAN
NC score	0.056343 (rank : 200)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	284	Target Neighborhood Hits	960	Shared Neighborhood Hits	39
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

FGD1_MOUSE
NC score	0.056331 (rank : 201)	θ value	0.62314 (rank : 163)
Query Neighborhood Hits	284	Target Neighborhood Hits	387	Shared Neighborhood Hits	44
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

EPHA5_HUMAN
NC score	0.056292 (rank : 202)	θ value	0.279714 (rank : 150)
Query Neighborhood Hits	284	Target Neighborhood Hits	1009	Shared Neighborhood Hits	45
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHA2_HUMAN
NC score	0.056209 (rank : 203)	θ value	0.00509761 (rank : 104)
Query Neighborhood Hits	284	Target Neighborhood Hits	1021	Shared Neighborhood Hits	43
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHB2_HUMAN
NC score	0.055970 (rank : 204)	θ value	0.0330416 (rank : 113)
Query Neighborhood Hits	284	Target Neighborhood Hits	983	Shared Neighborhood Hits	40
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

IASPP_MOUSE
NC score	0.055907 (rank : 205)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	284	Target Neighborhood Hits	1024	Shared Neighborhood Hits	50
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

PKHB2_MOUSE
NC score	0.055885 (rank : 206)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	284	Target Neighborhood Hits	48	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

FGD6_HUMAN
NC score	0.055855 (rank : 207)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	284	Target Neighborhood Hits	237	Shared Neighborhood Hits	58
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

EPHA7_MOUSE
NC score	0.055750 (rank : 208)	θ value	0.0736092 (rank : 126)
Query Neighborhood Hits	284	Target Neighborhood Hits	1025	Shared Neighborhood Hits	40
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHB1_HUMAN
NC score	0.055713 (rank : 209)	θ value	0.0736092 (rank : 127)
Query Neighborhood Hits	284	Target Neighborhood Hits	988	Shared Neighborhood Hits	41
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

ANKS1_MOUSE
NC score	0.055582 (rank : 210)	θ value	5.27518 (rank : 244)
Query Neighborhood Hits	284	Target Neighborhood Hits	453	Shared Neighborhood Hits	61
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

EPHB2_MOUSE
NC score	0.055454 (rank : 211)	θ value	0.0330416 (rank : 114)
Query Neighborhood Hits	284	Target Neighborhood Hits	982	Shared Neighborhood Hits	40
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

ANS4B_HUMAN
NC score	0.055331 (rank : 212)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	284	Target Neighborhood Hits	289	Shared Neighborhood Hits	24
SwissProt Accessions	Q8N8V4	Gene names	ANKS4B, HARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

IKBB_HUMAN
NC score	0.055282 (rank : 213)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	284	Target Neighborhood Hits	284	Shared Neighborhood Hits	26
SwissProt Accessions	Q15653, Q96BJ7	Gene names	NFKBIB, IKBB, TRIP9
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9).

FARP2_HUMAN
NC score	0.055135 (rank : 214)	θ value	3.0926 (rank : 221)
Query Neighborhood Hits	284	Target Neighborhood Hits	240	Shared Neighborhood Hits	48
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

PKHB1_MOUSE
NC score	0.055070 (rank : 215)	θ value	3.0926 (rank : 228)
Query Neighborhood Hits	284	Target Neighborhood Hits	47	Shared Neighborhood Hits	29
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

MTPN_HUMAN
NC score	0.054966 (rank : 216)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	284	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	P58546	Gene names	MTPN
Domain Architecture
Description	Myotrophin (Protein V-1).

TARA_MOUSE
NC score	0.054644 (rank : 217)	θ value	0.62314 (rank : 168)
Query Neighborhood Hits	284	Target Neighborhood Hits	1133	Shared Neighborhood Hits	73
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

MTMRD_HUMAN
NC score	0.054286 (rank : 218)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	284	Target Neighborhood Hits	135	Shared Neighborhood Hits	52
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

CDN2D_HUMAN
NC score	0.054270 (rank : 219)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	284	Target Neighborhood Hits	268	Shared Neighborhood Hits	21
SwissProt Accessions	P55273, Q13102, Q6FGE9	Gene names	CDKN2D
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

EPHB3_HUMAN
NC score	0.053788 (rank : 220)	θ value	0.365318 (rank : 155)
Query Neighborhood Hits	284	Target Neighborhood Hits	996	Shared Neighborhood Hits	40
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

ILK2_HUMAN
NC score	0.053584 (rank : 221)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	284	Target Neighborhood Hits	848	Shared Neighborhood Hits	54
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

P85B_MOUSE
NC score	0.053175 (rank : 222)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	284	Target Neighborhood Hits	519	Shared Neighborhood Hits	42
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

ANKR2_HUMAN
NC score	0.052996 (rank : 223)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	284	Target Neighborhood Hits	321	Shared Neighborhood Hits	26
SwissProt Accessions	Q9GZV1, Q5T456, Q8WUD7	Gene names	ANKRD2, ARPP
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp).

FGD6_MOUSE
NC score	0.052921 (rank : 224)	θ value	2.36792 (rank : 208)
Query Neighborhood Hits	284	Target Neighborhood Hits	282	Shared Neighborhood Hits	51
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

ANR10_HUMAN
NC score	0.052912 (rank : 225)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	284	Target Neighborhood Hits	289	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NXR5	Gene names	ANKRD10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

EPHB3_MOUSE
NC score	0.052716 (rank : 226)	θ value	1.38821 (rank : 186)
Query Neighborhood Hits	284	Target Neighborhood Hits	996	Shared Neighborhood Hits	39
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

ILK1_HUMAN
NC score	0.052558 (rank : 227)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	284	Target Neighborhood Hits	857	Shared Neighborhood Hits	54
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

MYPT1_MOUSE
NC score	0.052445 (rank : 228)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	284	Target Neighborhood Hits	539	Shared Neighborhood Hits	36
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

ASB10_HUMAN
NC score	0.052422 (rank : 229)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	284	Target Neighborhood Hits	291	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WXI3	Gene names	ASB10
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

MYPT1_HUMAN
NC score	0.052308 (rank : 230)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	284	Target Neighborhood Hits	723	Shared Neighborhood Hits	43
SwissProt Accessions	O14974, Q86WU3, Q8NFR6, Q9BYH0	Gene names	PPP1R12A, MBS, MYPT1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit).

FARP2_MOUSE
NC score	0.052219 (rank : 231)	θ value	2.36792 (rank : 207)
Query Neighborhood Hits	284	Target Neighborhood Hits	209	Shared Neighborhood Hits	54
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ANKR6_HUMAN
NC score	0.051774 (rank : 232)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	284	Target Neighborhood Hits	439	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y2G4, Q9NU24, Q9UFQ9	Gene names	ANKRD6, KIAA0957
Domain Architecture
Description	Ankyrin repeat domain-containing protein 6.

ILK_MOUSE
NC score	0.051714 (rank : 233)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	284	Target Neighborhood Hits	858	Shared Neighborhood Hits	54
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

EPHB4_MOUSE
NC score	0.051694 (rank : 234)	θ value	1.81305 (rank : 197)
Query Neighborhood Hits	284	Target Neighborhood Hits	1013	Shared Neighborhood Hits	41
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

ANR42_HUMAN
NC score	0.051652 (rank : 235)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	284	Target Neighborhood Hits	284	Shared Neighborhood Hits	26
SwissProt Accessions	Q8N9B4, Q49A49	Gene names	ANKRD42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

USH1G_MOUSE
NC score	0.051421 (rank : 236)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	284	Target Neighborhood Hits	271	Shared Neighborhood Hits	26
SwissProt Accessions	Q80T11, Q80UG0	Gene names	Ush1g, Sans
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein homolog (Scaffold protein containing ankyrin repeats and SAM domain) (Jackson shaker protein).

USH1G_HUMAN
NC score	0.051211 (rank : 237)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	284	Target Neighborhood Hits	267	Shared Neighborhood Hits	26
SwissProt Accessions	Q495M9, Q8N251	Gene names	USH1G, SANS
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein (Scaffold protein containing ankyrin repeats and SAM domain).

EPHB4_HUMAN
NC score	0.051095 (rank : 238)	θ value	2.36792 (rank : 206)
Query Neighborhood Hits	284	Target Neighborhood Hits	1056	Shared Neighborhood Hits	41
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

FGD4_HUMAN
NC score	0.050841 (rank : 239)	θ value	6.88961 (rank : 262)
Query Neighborhood Hits	284	Target Neighborhood Hits	219	Shared Neighborhood Hits	51
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

ANK1_HUMAN
NC score	0.050733 (rank : 240)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	284	Target Neighborhood Hits	416	Shared Neighborhood Hits	27
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

ANK1_MOUSE
NC score	0.050655 (rank : 241)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	284	Target Neighborhood Hits	430	Shared Neighborhood Hits	28
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

ANR10_MOUSE
NC score	0.050424 (rank : 242)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	284	Target Neighborhood Hits	273	Shared Neighborhood Hits	26
SwissProt Accessions	Q99LW0	Gene names	Ankrd10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

PKHB1_HUMAN
NC score	0.050401 (rank : 243)	θ value	6.88961 (rank : 264)
Query Neighborhood Hits	284	Target Neighborhood Hits	46	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

PSD10_HUMAN
NC score	0.050366 (rank : 244)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	284	Target Neighborhood Hits	301	Shared Neighborhood Hits	26
SwissProt Accessions	O75832	Gene names	PSMD10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

ANKS1_HUMAN
NC score	0.050290 (rank : 245)	θ value	8.99809 (rank : 269)
Query Neighborhood Hits	284	Target Neighborhood Hits	438	Shared Neighborhood Hits	59
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

ASB10_MOUSE
NC score	0.050289 (rank : 246)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	284	Target Neighborhood Hits	301	Shared Neighborhood Hits	26
SwissProt Accessions	Q91ZT7	Gene names	Asb10
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

SAMN1_HUMAN
NC score	0.048871 (rank : 247)	θ value	0.813845 (rank : 175)
Query Neighborhood Hits	284	Target Neighborhood Hits	74	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

EPHA5_MOUSE
NC score	0.046106 (rank : 248)	θ value	5.27518 (rank : 250)
Query Neighborhood Hits	284	Target Neighborhood Hits	950	Shared Neighborhood Hits	41
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

FGD5_MOUSE
NC score	0.045279 (rank : 249)	θ value	3.0926 (rank : 222)
Query Neighborhood Hits	284	Target Neighborhood Hits	170	Shared Neighborhood Hits	41
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

ANLN_MOUSE
NC score	0.043804 (rank : 250)	θ value	8.99809 (rank : 270)
Query Neighborhood Hits	284	Target Neighborhood Hits	297	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

GRB14_HUMAN
NC score	0.041995 (rank : 251)	θ value	3.0926 (rank : 224)
Query Neighborhood Hits	284	Target Neighborhood Hits	137	Shared Neighborhood Hits	23
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

TARA_HUMAN
NC score	0.041963 (rank : 252)	θ value	1.38821 (rank : 193)
Query Neighborhood Hits	284	Target Neighborhood Hits	1626	Shared Neighborhood Hits	78
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

SAMN1_MOUSE
NC score	0.040328 (rank : 253)	θ value	2.36792 (rank : 213)
Query Neighborhood Hits	284	Target Neighborhood Hits	69	Shared Neighborhood Hits	14
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

OSBL1_MOUSE
NC score	0.040230 (rank : 254)	θ value	8.99809 (rank : 277)
Query Neighborhood Hits	284	Target Neighborhood Hits	336	Shared Neighborhood Hits	38
SwissProt Accessions	Q91XL9, O88318, Q3TH97, Q673L8, Q6DFU6	Gene names	Osbpl1a, Orp1, Orp1a
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

ANLN_HUMAN
NC score	0.039720 (rank : 255)	θ value	5.27518 (rank : 245)
Query Neighborhood Hits	284	Target Neighborhood Hits	222	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NQW6, Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0	Gene names	ANLN
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

GRB10_MOUSE
NC score	0.039696 (rank : 256)	θ value	4.03905 (rank : 236)
Query Neighborhood Hits	284	Target Neighborhood Hits	156	Shared Neighborhood Hits	23
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB14_MOUSE
NC score	0.038590 (rank : 257)	θ value	1.38821 (rank : 188)
Query Neighborhood Hits	284	Target Neighborhood Hits	149	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

STAP2_MOUSE
NC score	0.037260 (rank : 258)	θ value	1.38821 (rank : 192)
Query Neighborhood Hits	284	Target Neighborhood Hits	41	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R0L1, Q8BWS2	Gene names	Stap2
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 2 (STAP-2).

TEC_MOUSE
NC score	0.036443 (rank : 259)	θ value	0.813845 (rank : 176)
Query Neighborhood Hits	284	Target Neighborhood Hits	1006	Shared Neighborhood Hits	61
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ITK_HUMAN
NC score	0.033432 (rank : 260)	θ value	1.38821 (rank : 189)
Query Neighborhood Hits	284	Target Neighborhood Hits	1016	Shared Neighborhood Hits	62
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

PKHF2_MOUSE
NC score	0.033384 (rank : 261)	θ value	2.36792 (rank : 212)
Query Neighborhood Hits	284	Target Neighborhood Hits	77	Shared Neighborhood Hits	23
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHF2_HUMAN
NC score	0.032641 (rank : 262)	θ value	2.36792 (rank : 211)
Query Neighborhood Hits	284	Target Neighborhood Hits	75	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

OSBL7_HUMAN
NC score	0.031821 (rank : 263)	θ value	3.0926 (rank : 227)
Query Neighborhood Hits	284	Target Neighborhood Hits	71	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BZF2	Gene names	OSBPL7, ORP7
Domain Architecture
Description	Oxysterol-binding protein-related protein 7 (OSBP-related protein 7) (ORP-7).

C8AP2_HUMAN
NC score	0.031704 (rank : 264)	θ value	0.0330416 (rank : 112)
Query Neighborhood Hits	284	Target Neighborhood Hits	548	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UKL3, Q6PH76, Q7LCQ7, Q86YD9, Q9NUQ4, Q9NZV9, Q9P2N1, Q9Y563	Gene names	CASP8AP2, FLASH, KIAA1315, RIP25
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

PCLO_HUMAN
NC score	0.031677 (rank : 265)	θ value	1.81305 (rank : 201)
Query Neighborhood Hits	284	Target Neighborhood Hits	2046	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PKHF1_MOUSE
NC score	0.030733 (rank : 266)	θ value	8.99809 (rank : 279)
Query Neighborhood Hits	284	Target Neighborhood Hits	80	Shared Neighborhood Hits	21
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

POTE1_HUMAN
NC score	0.029327 (rank : 267)	θ value	0.21417 (rank : 147)
Query Neighborhood Hits	284	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NUX5, O95018, Q9H662, Q9NW19, Q9UG95	Gene names	POT1
Domain Architecture	No domain graphic available
Description	Protection of telomeres 1 (hPot1) (POT1-like telomere end-binding protein).

CI084_HUMAN
NC score	0.029195 (rank : 268)	θ value	1.38821 (rank : 183)
Query Neighborhood Hits	284	Target Neighborhood Hits	40	Shared Neighborhood Hits	6
SwissProt Accessions	Q5VXU9, Q96M73	Gene names	C9orf84
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf84.

SLY_MOUSE
NC score	0.026789 (rank : 269)	θ value	8.99809 (rank : 282)
Query Neighborhood Hits	284	Target Neighborhood Hits	108	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

RB39B_MOUSE
NC score	0.025751 (rank : 270)	θ value	4.03905 (rank : 240)
Query Neighborhood Hits	284	Target Neighborhood Hits	277	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BHC1, Q3TUJ3	Gene names	Rab39b
Domain Architecture
Description	Ras-related protein Rab-39B.

RB39B_HUMAN
NC score	0.025732 (rank : 271)	θ value	4.03905 (rank : 239)
Query Neighborhood Hits	284	Target Neighborhood Hits	279	Shared Neighborhood Hits	21
SwissProt Accessions	Q96DA2, Q5JT79, Q8NEX3	Gene names	RAB39B
Domain Architecture
Description	Ras-related protein Rab-39B.

RAB13_MOUSE
NC score	0.025310 (rank : 272)	θ value	0.125558 (rank : 140)
Query Neighborhood Hits	284	Target Neighborhood Hits	289	Shared Neighborhood Hits	20
SwissProt Accessions	Q9DD03	Gene names	Rab13
Domain Architecture
Description	Ras-related protein Rab-13.

RAB13_HUMAN
NC score	0.023690 (rank : 273)	θ value	0.0961366 (rank : 134)
Query Neighborhood Hits	284	Target Neighborhood Hits	286	Shared Neighborhood Hits	20
SwissProt Accessions	P51153, Q96GU4	Gene names	RAB13
Domain Architecture
Description	Ras-related protein Rab-13.

CLCN1_HUMAN
NC score	0.023255 (rank : 274)	θ value	0.279714 (rank : 148)
Query Neighborhood Hits	284	Target Neighborhood Hits	89	Shared Neighborhood Hits	5
SwissProt Accessions	P35523	Gene names	CLCN1, CLC1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

WWP1_HUMAN
NC score	0.022717 (rank : 275)	θ value	0.00175202 (rank : 95)
Query Neighborhood Hits	284	Target Neighborhood Hits	262	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

RB39A_HUMAN
NC score	0.021219 (rank : 276)	θ value	3.0926 (rank : 231)
Query Neighborhood Hits	284	Target Neighborhood Hits	276	Shared Neighborhood Hits	21
SwissProt Accessions	Q14964, Q8N6W2	Gene names	RAB39, RAB39A
Domain Architecture
Description	Ras-related protein Rab-39A (Rab-39).

STAP2_HUMAN
NC score	0.021128 (rank : 277)	θ value	6.88961 (rank : 266)
Query Neighborhood Hits	284	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UGK3, Q9NXI2	Gene names	STAP2, BKS
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 2 (STAP-2) (Breast tumor kinase substrate) (BRK substrate).

GCC2_HUMAN
NC score	0.020585 (rank : 278)	θ value	1.06291 (rank : 177)
Query Neighborhood Hits	284	Target Neighborhood Hits	1558	Shared Neighborhood Hits	59
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

RBP24_HUMAN
NC score	0.020537 (rank : 279)	θ value	1.06291 (rank : 180)
Query Neighborhood Hits	284	Target Neighborhood Hits	1559	Shared Neighborhood Hits	59
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

RB39A_MOUSE
NC score	0.019469 (rank : 280)	θ value	8.99809 (rank : 280)
Query Neighborhood Hits	284	Target Neighborhood Hits	279	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BHD0	Gene names	Rab39, Rab39a
Domain Architecture
Description	Ras-related protein Rab-39A (Rab-39).

GUC2G_MOUSE
NC score	0.019407 (rank : 281)	θ value	1.81305 (rank : 199)
Query Neighborhood Hits	284	Target Neighborhood Hits	644	Shared Neighborhood Hits	25
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

ALS2_HUMAN
NC score	0.018598 (rank : 282)	θ value	5.27518 (rank : 242)
Query Neighborhood Hits	284	Target Neighborhood Hits	121	Shared Neighborhood Hits	22
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

COMDA_HUMAN
NC score	0.018330 (rank : 283)	θ value	2.36792 (rank : 204)
Query Neighborhood Hits	284	Target Neighborhood Hits	21	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y6G5, Q9P077	Gene names	COMMD10
Domain Architecture	No domain graphic available
Description	COMM domain-containing protein 10.

SMC1A_HUMAN
NC score	0.018290 (rank : 284)	θ value	2.36792 (rank : 214)
Query Neighborhood Hits	284	Target Neighborhood Hits	1346	Shared Neighborhood Hits	43
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

DNMT2_MOUSE
NC score	0.018196 (rank : 285)	θ value	1.81305 (rank : 196)
Query Neighborhood Hits	284	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	O55055, O35212	Gene names	Dnmt2, Met2
Domain Architecture
Description	tRNA (cytosine-5-)-methyltransferase (EC 2.1.1.29) (DNA (cytosine-5)- methyltransferase-like protein 2) (Dnmt2) (DNA methyltransferase homolog MmuIIP) (DNA MTase homolog MmuIIP) (M.MmuIIP) (Met-2).

CENPE_HUMAN
NC score	0.018067 (rank : 286)	θ value	0.21417 (rank : 145)
Query Neighborhood Hits	284	Target Neighborhood Hits	2060	Shared Neighborhood Hits	69
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

SMC1A_MOUSE
NC score	0.018059 (rank : 287)	θ value	2.36792 (rank : 215)
Query Neighborhood Hits	284	Target Neighborhood Hits	1384	Shared Neighborhood Hits	44
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

ALS2_MOUSE
NC score	0.017891 (rank : 288)	θ value	5.27518 (rank : 243)
Query Neighborhood Hits	284	Target Neighborhood Hits	111	Shared Neighborhood Hits	18
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

XPO7_MOUSE
NC score	0.017883 (rank : 289)	θ value	5.27518 (rank : 256)
Query Neighborhood Hits	284	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EPK7, Q3TP94, Q80TS9, Q8BSK5, Q8C9M7, Q8CB42, Q8CBL8, Q8CEF5	Gene names	Xpo7, Kiaa0745, Ranbp16
Domain Architecture
Description	Exportin-7 (Exp7) (Ran-binding protein 16).

XPO7_HUMAN
NC score	0.017860 (rank : 290)	θ value	5.27518 (rank : 255)
Query Neighborhood Hits	284	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UIA9, O94846, Q6PJK9, Q8NEK7	Gene names	XPO7, KIAA0745, RANBP16
Domain Architecture
Description	Exportin-7 (Exp7) (Ran-binding protein 16).

M3K13_HUMAN
NC score	0.016960 (rank : 291)	θ value	2.36792 (rank : 209)
Query Neighborhood Hits	284	Target Neighborhood Hits	911	Shared Neighborhood Hits	32
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

FLIP1_HUMAN
NC score	0.016617 (rank : 292)	θ value	1.81305 (rank : 198)
Query Neighborhood Hits	284	Target Neighborhood Hits	1405	Shared Neighborhood Hits	44
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

HMGA2_HUMAN
NC score	0.016500 (rank : 293)	θ value	8.99809 (rank : 274)
Query Neighborhood Hits	284	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	P52926	Gene names	HMGA2, HMGIC
Domain Architecture	No domain graphic available
Description	High mobility group protein HMGI-C (High mobility group AT-hook protein 2).

IL17C_HUMAN
NC score	0.016343 (rank : 294)	θ value	4.03905 (rank : 237)
Query Neighborhood Hits	284	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P0M4, Q3MIG8, Q9HC75	Gene names	IL17C
Domain Architecture
Description	Interleukin-17C precursor (IL-17C) (Cytokine CX2).

BRCA2_HUMAN
NC score	0.015979 (rank : 295)	θ value	1.38821 (rank : 182)
Query Neighborhood Hits	284	Target Neighborhood Hits	202	Shared Neighborhood Hits	9
SwissProt Accessions	P51587, O00183, O15008, Q13879	Gene names	BRCA2, FANCD1
Domain Architecture
Description	Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein).

FYB_MOUSE
NC score	0.015926 (rank : 296)	θ value	3.0926 (rank : 223)
Query Neighborhood Hits	284	Target Neighborhood Hits	194	Shared Neighborhood Hits	9
SwissProt Accessions	O35601, Q9Z2H3	Gene names	Fyb
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

CM007_HUMAN
NC score	0.015787 (rank : 297)	θ value	0.813845 (rank : 170)
Query Neighborhood Hits	284	Target Neighborhood Hits	422	Shared Neighborhood Hits	10
SwissProt Accessions	Q5W0B1, Q8TBY2, Q9H0T2, Q9H8M0	Gene names	C13orf7
Domain Architecture	No domain graphic available
Description	Protein C13orf7.

CEP70_MOUSE
NC score	0.015669 (rank : 298)	θ value	8.99809 (rank : 272)
Query Neighborhood Hits	284	Target Neighborhood Hits	532	Shared Neighborhood Hits	26
SwissProt Accessions	Q6IQY5, Q9CRL9, Q9CTS4, Q9JIC1	Gene names	Cep70
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 70 kDa (Cep70 protein).

SYCP1_MOUSE
NC score	0.015149 (rank : 299)	θ value	8.99809 (rank : 283)
Query Neighborhood Hits	284	Target Neighborhood Hits	1456	Shared Neighborhood Hits	54
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

MTA3_HUMAN
NC score	0.014761 (rank : 300)	θ value	0.279714 (rank : 153)
Query Neighborhood Hits	284	Target Neighborhood Hits	37	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BTC8, Q9NSP2, Q9ULF4	Gene names	MTA3, KIAA1266
Domain Architecture
Description	Metastasis-associated protein MTA3.

APS_MOUSE
NC score	0.014564 (rank : 301)	θ value	6.88961 (rank : 258)
Query Neighborhood Hits	284	Target Neighborhood Hits	134	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

FLIP1_MOUSE
NC score	0.014404 (rank : 302)	θ value	1.38821 (rank : 187)
Query Neighborhood Hits	284	Target Neighborhood Hits	1176	Shared Neighborhood Hits	38
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

KIF1B_HUMAN
NC score	0.014341 (rank : 303)	θ value	1.81305 (rank : 200)
Query Neighborhood Hits	284	Target Neighborhood Hits	178	Shared Neighborhood Hits	26
SwissProt Accessions	O60333, Q96Q94, Q9BV80, Q9P280	Gene names	KIF1B, KIAA0591, KIAA1448
Domain Architecture
Description	Kinesin-like protein KIF1B (Klp).

RAB8A_MOUSE
NC score	0.014255 (rank : 304)	θ value	0.62314 (rank : 167)
Query Neighborhood Hits	284	Target Neighborhood Hits	269	Shared Neighborhood Hits	15
SwissProt Accessions	P55258, Q8VCF6	Gene names	Rab8a, Mel, Rab8
Domain Architecture
Description	Ras-related protein Rab-8A (Oncogene c-mel).

RAB8A_HUMAN
NC score	0.014210 (rank : 305)	θ value	0.62314 (rank : 166)
Query Neighborhood Hits	284	Target Neighborhood Hits	269	Shared Neighborhood Hits	15
SwissProt Accessions	P61006, P24407	Gene names	RAB8A, MEL, RAB8
Domain Architecture
Description	Ras-related protein Rab-8A (Oncogene c-mel).

KIF1B_MOUSE
NC score	0.014116 (rank : 306)	θ value	1.06291 (rank : 179)
Query Neighborhood Hits	284	Target Neighborhood Hits	167	Shared Neighborhood Hits	23
SwissProt Accessions	Q60575, Q9R0B4, Q9WVE5, Q9Z119	Gene names	Kif1b
Domain Architecture
Description	Kinesin-like protein KIF1B.

RAB10_HUMAN
NC score	0.013969 (rank : 307)	θ value	3.0926 (rank : 229)
Query Neighborhood Hits	284	Target Neighborhood Hits	278	Shared Neighborhood Hits	18
SwissProt Accessions	P61026, O88386, Q6IA52, Q9D7X6, Q9H0T3	Gene names	RAB10
Domain Architecture
Description	Ras-related protein Rab-10.

RAB10_MOUSE
NC score	0.013969 (rank : 308)	θ value	3.0926 (rank : 230)
Query Neighborhood Hits	284	Target Neighborhood Hits	278	Shared Neighborhood Hits	18
SwissProt Accessions	P61027, O88386, Q9D7X6	Gene names	Rab10
Domain Architecture
Description	Ras-related protein Rab-10.

SOS2_HUMAN
NC score	0.013898 (rank : 309)	θ value	5.27518 (rank : 254)
Query Neighborhood Hits	284	Target Neighborhood Hits	193	Shared Neighborhood Hits	17
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

CLCN1_MOUSE
NC score	0.013888 (rank : 310)	θ value	4.03905 (rank : 233)
Query Neighborhood Hits	284	Target Neighborhood Hits	61	Shared Neighborhood Hits	5
SwissProt Accessions	Q64347	Gene names	Clcn1, Clc1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

ATF2_MOUSE
NC score	0.013625 (rank : 311)	θ value	1.38821 (rank : 181)
Query Neighborhood Hits	284	Target Neighborhood Hits	397	Shared Neighborhood Hits	8
SwissProt Accessions	P16951, Q64089, Q64090, Q64091	Gene names	Atf2
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-2 (Activating transcription factor 2) (cAMP response element-binding protein CRE- BP1) (MXBP protein).

SYTL2_HUMAN
NC score	0.013205 (rank : 312)	θ value	2.36792 (rank : 217)
Query Neighborhood Hits	284	Target Neighborhood Hits	248	Shared Neighborhood Hits	15
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

CYLC1_HUMAN
NC score	0.013190 (rank : 313)	θ value	4.03905 (rank : 234)
Query Neighborhood Hits	284	Target Neighborhood Hits	408	Shared Neighborhood Hits	15
SwissProt Accessions	P35663, Q5JQQ9	Gene names	CYLC1, CYL, CYL1
Domain Architecture	No domain graphic available
Description	Cylicin-1 (Cylicin I) (Multiple-band polypeptide I).

RAB8B_MOUSE
NC score	0.013034 (rank : 314)	θ value	0.813845 (rank : 174)
Query Neighborhood Hits	284	Target Neighborhood Hits	277	Shared Neighborhood Hits	15
SwissProt Accessions	P61028, Q3U1Z3	Gene names	Rab8b
Domain Architecture
Description	Ras-related protein Rab-8B.

RAB8B_HUMAN
NC score	0.012821 (rank : 315)	θ value	0.813845 (rank : 173)
Query Neighborhood Hits	284	Target Neighborhood Hits	275	Shared Neighborhood Hits	15
SwissProt Accessions	Q92930, Q9P293	Gene names	RAB8B
Domain Architecture
Description	Ras-related protein Rab-8B.

PYRD_HUMAN
NC score	0.012737 (rank : 316)	θ value	4.03905 (rank : 238)
Query Neighborhood Hits	284	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q02127, Q6P176	Gene names	DHODH
Domain Architecture	No domain graphic available
Description	Dihydroorotate dehydrogenase, mitochondrial precursor (EC 1.3.3.1) (Dihydroorotate oxidase) (DHOdehase).

CAC1B_MOUSE
NC score	0.012735 (rank : 317)	θ value	0.125558 (rank : 135)
Query Neighborhood Hits	284	Target Neighborhood Hits	351	Shared Neighborhood Hits	16
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

ZCH11_HUMAN
NC score	0.012663 (rank : 318)	θ value	1.81305 (rank : 203)
Query Neighborhood Hits	284	Target Neighborhood Hits	278	Shared Neighborhood Hits	8
SwissProt Accessions	Q5TAX3, Q12764, Q5TAX4, Q86XZ3	Gene names	ZCCHC11, KIAA0191
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 11.

SDCG8_MOUSE
NC score	0.012119 (rank : 319)	θ value	8.99809 (rank : 281)
Query Neighborhood Hits	284	Target Neighborhood Hits	886	Shared Neighborhood Hits	32
SwissProt Accessions	Q80UF4	Gene names	Sdccag8, Cccap
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (mCCCAP).

CEP35_HUMAN
NC score	0.011921 (rank : 320)	θ value	8.99809 (rank : 271)
Query Neighborhood Hits	284	Target Neighborhood Hits	811	Shared Neighborhood Hits	35
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

ATF2_HUMAN
NC score	0.011710 (rank : 321)	θ value	3.0926 (rank : 218)
Query Neighborhood Hits	284	Target Neighborhood Hits	402	Shared Neighborhood Hits	8
SwissProt Accessions	P15336, Q13000	Gene names	ATF2, CREB2, CREBP1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-2 (Activating transcription factor 2) (cAMP response element-binding protein CRE- BP1) (HB16).

SYTL4_HUMAN
NC score	0.011281 (rank : 322)	θ value	8.99809 (rank : 284)
Query Neighborhood Hits	284	Target Neighborhood Hits	138	Shared Neighborhood Hits	14
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

TXND2_MOUSE
NC score	0.011188 (rank : 323)	θ value	1.38821 (rank : 194)
Query Neighborhood Hits	284	Target Neighborhood Hits	828	Shared Neighborhood Hits	27
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

KCNH7_MOUSE
NC score	0.010772 (rank : 324)	θ value	1.06291 (rank : 178)
Query Neighborhood Hits	284	Target Neighborhood Hits	98	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ER47	Gene names	Kcnh7, Erg3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (Ether-a-go-go-related protein 3) (Eag-related protein 3).

SMC4_MOUSE
NC score	0.010644 (rank : 325)	θ value	2.36792 (rank : 216)
Query Neighborhood Hits	284	Target Neighborhood Hits	830	Shared Neighborhood Hits	25
SwissProt Accessions	Q8CG47, Q8BTS7, Q8BTY9, Q99K21	Gene names	Smc4l1, Capc, Smc4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (XCAP-C homolog).

CASC5_HUMAN
NC score	0.010567 (rank : 326)	θ value	6.88961 (rank : 259)
Query Neighborhood Hits	284	Target Neighborhood Hits	376	Shared Neighborhood Hits	18
SwissProt Accessions	Q8NG31, Q8NHE1, Q8WXA6, Q9HCK2, Q9NR92	Gene names	CASC5, KIAA1570
Domain Architecture	No domain graphic available
Description	Protein CASC5 (Cancer susceptibility candidate gene 5 protein) (ALL1- fused gene from chromosome 15q14) (AF15q14) (D40/AF15q14 protein).

RIF1_HUMAN
NC score	0.009975 (rank : 327)	θ value	4.03905 (rank : 241)
Query Neighborhood Hits	284	Target Neighborhood Hits	320	Shared Neighborhood Hits	9
SwissProt Accessions	Q5UIP0, Q5H9R3, Q5UIP2, Q66YK6, Q6PRU2, Q8TE94, Q99772, Q9H830, Q9H9B9, Q9NVP5, Q9Y4R4	Gene names	RIF1
Domain Architecture	No domain graphic available
Description	Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog).

KCNH7_HUMAN
NC score	0.009955 (rank : 328)	θ value	1.38821 (rank : 190)
Query Neighborhood Hits	284	Target Neighborhood Hits	107	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NS40	Gene names	KCNH7, ERG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (HERG-3) (Ether-a-go-go-related protein 3) (Eag- related protein 3).

E41LA_MOUSE
NC score	0.009944 (rank : 329)	θ value	2.36792 (rank : 205)
Query Neighborhood Hits	284	Target Neighborhood Hits	85	Shared Neighborhood Hits	7
SwissProt Accessions	P52963	Gene names	Epb41l4a, Epb4.1l4, Epb4.1l4a, Epb41l4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

ALEX_MOUSE
NC score	0.009300 (rank : 330)	θ value	8.99809 (rank : 268)
Query Neighborhood Hits	284	Target Neighborhood Hits	197	Shared Neighborhood Hits	6
SwissProt Accessions	Q6R0H6, Q8BIR3	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

PDYN_HUMAN
NC score	0.007717 (rank : 331)	θ value	8.99809 (rank : 278)
Query Neighborhood Hits	284	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	P01213	Gene names	PDYN
Domain Architecture
Description	Beta-neoendorphin-dynorphin precursor (Proenkephalin B) (Preprodynorphin) [Contains: Beta-neoendorphin; Dynorphin; Leu- enkephalin; Rimorphin; Leumorphin].

K0372_HUMAN
NC score	0.007288 (rank : 332)	θ value	6.88961 (rank : 263)
Query Neighborhood Hits	284	Target Neighborhood Hits	136	Shared Neighborhood Hits	5
SwissProt Accessions	Q6PGP7, O15077, Q6PJI3	Gene names	KIAA0372
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein KIAA0372 (TPR repeat protein KIAA0372).

AKT1_HUMAN
NC score	0.006866 (rank : 333)	θ value	8.99809 (rank : 267)
Query Neighborhood Hits	284	Target Neighborhood Hits	885	Shared Neighborhood Hits	61
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

ALMS1_HUMAN
NC score	0.006632 (rank : 334)	θ value	6.88961 (rank : 257)
Query Neighborhood Hits	284	Target Neighborhood Hits	356	Shared Neighborhood Hits	10
SwissProt Accessions	Q8TCU4, Q53S05, Q580Q8, Q86VP9, Q9Y4G4	Gene names	ALMS1, KIAA0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1.

MX1_HUMAN
NC score	0.006613 (rank : 335)	θ value	3.0926 (rank : 225)
Query Neighborhood Hits	284	Target Neighborhood Hits	62	Shared Neighborhood Hits	2
SwissProt Accessions	P20591	Gene names	MX1
Domain Architecture
Description	Interferon-induced GTP-binding protein Mx1 (Interferon-regulated resistance GTP-binding protein MxA) (Interferon-induced protein p78) (IFI-78K).

LARP4_HUMAN
NC score	0.006352 (rank : 336)	θ value	8.99809 (rank : 276)
Query Neighborhood Hits	284	Target Neighborhood Hits	69	Shared Neighborhood Hits	4
SwissProt Accessions	Q71RC2, Q5CZ97, Q96NF9	Gene names	LARP4
Domain Architecture	No domain graphic available
Description	La-related protein 4 (La ribonucleoprotein domain family member 4).

DNL1_MOUSE
NC score	0.006276 (rank : 337)	θ value	8.99809 (rank : 273)
Query Neighborhood Hits	284	Target Neighborhood Hits	110	Shared Neighborhood Hits	8
SwissProt Accessions	P37913	Gene names	Lig1, Lig-1
Domain Architecture
Description	DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1).

PKNX2_HUMAN
NC score	0.006008 (rank : 338)	θ value	5.27518 (rank : 252)
Query Neighborhood Hits	284	Target Neighborhood Hits	133	Shared Neighborhood Hits	4
SwissProt Accessions	Q96KN3, Q63HL6, Q86XD1	Gene names	PKNOX2, PREP2
Domain Architecture
Description	Homeobox protein PKNOX2 (PBX/knotted homeobox 2) (Homeobox protein PREP-2).

JHD2C_HUMAN
NC score	0.005839 (rank : 339)	θ value	5.27518 (rank : 251)
Query Neighborhood Hits	284	Target Neighborhood Hits	279	Shared Neighborhood Hits	14
SwissProt Accessions	Q15652, Q5SQZ8, Q5SQZ9, Q5SR00, Q7Z3E7, Q8N3U0, Q96KB9, Q9P2G7	Gene names	JMJD1C, JHDM2C, KIAA1380, TRIP8
Domain Architecture	No domain graphic available
Description	Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TRIP-8).

AIRE_HUMAN
NC score	0.005808 (rank : 340)	θ value	4.03905 (rank : 232)
Query Neighborhood Hits	284	Target Neighborhood Hits	144	Shared Neighborhood Hits	4
SwissProt Accessions	O43918, O43922, O43932, O75745	Gene names	AIRE, APECED
Domain Architecture
Description	Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein).

PKNX2_MOUSE
NC score	0.005748 (rank : 341)	θ value	5.27518 (rank : 253)
Query Neighborhood Hits	284	Target Neighborhood Hits	197	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BG99, Q8R4B0	Gene names	Pknox2, Prep2
Domain Architecture	No domain graphic available
Description	Homeobox protein PKNOX2 (PBX/knotted homeobox 2) (Homeobox protein PREP-2).

HSP74_MOUSE
NC score	0.004694 (rank : 342)	θ value	8.99809 (rank : 275)
Query Neighborhood Hits	284	Target Neighborhood Hits	257	Shared Neighborhood Hits	16
SwissProt Accessions	Q61316	Gene names	Hspa4, Hsp110
Domain Architecture
Description	Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2).

NEDD1_MOUSE
NC score	0.004405 (rank : 343)	θ value	3.0926 (rank : 226)
Query Neighborhood Hits	284	Target Neighborhood Hits	281	Shared Neighborhood Hits	3
SwissProt Accessions	P33215, Q6NXV3, Q8BN12, Q8BN86, Q8BQL9, Q9CWK2	Gene names	Nedd1, Nedd-1
Domain Architecture	No domain graphic available
Description	Protein NEDD1 (Neural precursor cell expressed developmentally down- regulated protein 1).

DNJC1_MOUSE
NC score	0.003315 (rank : 344)	θ value	6.88961 (rank : 261)
Query Neighborhood Hits	284	Target Neighborhood Hits	129	Shared Neighborhood Hits	5
SwissProt Accessions	Q61712	Gene names	Dnajc1, Dnajl1, Mtj1
Domain Architecture
Description	DnaJ homolog subfamily C member 1 (DnaJ protein homolog MTJ1).

DDX51_HUMAN
NC score	0.002962 (rank : 345)	θ value	3.0926 (rank : 220)
Query Neighborhood Hits	284	Target Neighborhood Hits	332	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

FCER2_MOUSE
NC score	0.002666 (rank : 346)	θ value	4.03905 (rank : 235)
Query Neighborhood Hits	284	Target Neighborhood Hits	392	Shared Neighborhood Hits	13
SwissProt Accessions	P20693, Q61556, Q61557	Gene names	Fcer2, Fcer2a
Domain Architecture
Description	Low affinity immunoglobulin epsilon Fc receptor (Lymphocyte IGE receptor) (Fc-epsilon-RII) (CD23 antigen).