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Network neighborhood for query Sequence : RHG12_HUMAN

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RHG12_HUMAN
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RHG12_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	190	Target Neighborhood Hits	190	Shared Neighborhood Hits	190
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	0 (rank : 2)	NC score	0.992007 (rank : 2)
Query Neighborhood Hits	190	Target Neighborhood Hits	204	Shared Neighborhood Hits	152
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG09_HUMAN
θ value	1.65806e-78 (rank : 3)	NC score	0.933039 (rank : 3)
Query Neighborhood Hits	190	Target Neighborhood Hits	186	Shared Neighborhood Hits	102
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

CHIO_HUMAN
θ value	1.4233e-29 (rank : 4)	NC score	0.757820 (rank : 22)
Query Neighborhood Hits	190	Target Neighborhood Hits	220	Shared Neighborhood Hits	73
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_MOUSE
θ value	1.4233e-29 (rank : 5)	NC score	0.785486 (rank : 11)
Query Neighborhood Hits	190	Target Neighborhood Hits	130	Shared Neighborhood Hits	61
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIN_MOUSE
θ value	3.17079e-29 (rank : 6)	NC score	0.760056 (rank : 21)
Query Neighborhood Hits	190	Target Neighborhood Hits	229	Shared Neighborhood Hits	75
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_HUMAN
θ value	4.14116e-29 (rank : 7)	NC score	0.756565 (rank : 24)
Query Neighborhood Hits	190	Target Neighborhood Hits	227	Shared Neighborhood Hits	73
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

ABR_HUMAN
θ value	3.87602e-27 (rank : 8)	NC score	0.745987 (rank : 27)
Query Neighborhood Hits	190	Target Neighborhood Hits	166	Shared Neighborhood Hits	67
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

GRLF1_HUMAN
θ value	3.87602e-27 (rank : 9)	NC score	0.799195 (rank : 4)
Query Neighborhood Hits	190	Target Neighborhood Hits	167	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

TCGAP_HUMAN
θ value	5.06226e-27 (rank : 10)	NC score	0.692146 (rank : 38)
Query Neighborhood Hits	190	Target Neighborhood Hits	872	Shared Neighborhood Hits	83
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	5.06226e-27 (rank : 11)	NC score	0.780060 (rank : 14)
Query Neighborhood Hits	190	Target Neighborhood Hits	409	Shared Neighborhood Hits	79
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

BCR_HUMAN
θ value	1.12775e-26 (rank : 12)	NC score	0.726408 (rank : 30)
Query Neighborhood Hits	190	Target Neighborhood Hits	204	Shared Neighborhood Hits	65
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

OPHN1_MOUSE
θ value	2.77775e-25 (rank : 13)	NC score	0.779594 (rank : 15)
Query Neighborhood Hits	190	Target Neighborhood Hits	174	Shared Neighborhood Hits	65
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

OPHN1_HUMAN
θ value	8.08199e-25 (rank : 14)	NC score	0.779425 (rank : 16)
Query Neighborhood Hits	190	Target Neighborhood Hits	161	Shared Neighborhood Hits	61
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

RHG26_HUMAN
θ value	1.5242e-23 (rank : 15)	NC score	0.743431 (rank : 28)
Query Neighborhood Hits	190	Target Neighborhood Hits	281	Shared Neighborhood Hits	83
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

3BP1_HUMAN
θ value	7.0802e-21 (rank : 16)	NC score	0.781147 (rank : 13)
Query Neighborhood Hits	190	Target Neighborhood Hits	376	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

MYO9B_HUMAN
θ value	7.0802e-21 (rank : 17)	NC score	0.412996 (rank : 60)
Query Neighborhood Hits	190	Target Neighborhood Hits	641	Shared Neighborhood Hits	68
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

RHG05_MOUSE
θ value	7.0802e-21 (rank : 18)	NC score	0.766197 (rank : 19)
Query Neighborhood Hits	190	Target Neighborhood Hits	165	Shared Neighborhood Hits	69
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

MYO9B_MOUSE
θ value	1.2077e-20 (rank : 19)	NC score	0.419175 (rank : 58)
Query Neighborhood Hits	190	Target Neighborhood Hits	311	Shared Neighborhood Hits	65
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

RHG05_HUMAN
θ value	2.97466e-19 (rank : 20)	NC score	0.756801 (rank : 23)
Query Neighborhood Hits	190	Target Neighborhood Hits	158	Shared Neighborhood Hits	67
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

SRGP2_HUMAN
θ value	5.07402e-19 (rank : 21)	NC score	0.723893 (rank : 31)
Query Neighborhood Hits	190	Target Neighborhood Hits	331	Shared Neighborhood Hits	100
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

RHG01_HUMAN
θ value	1.13037e-18 (rank : 22)	NC score	0.771394 (rank : 18)
Query Neighborhood Hits	190	Target Neighborhood Hits	75	Shared Neighborhood Hits	61
SwissProt Accessions	Q07960	Gene names	ARHGAP1, CDC42GAP, RHOGAP1
Domain Architecture
Description	Rho-GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (CDC42 GTPase-activating protein) (p50-RhoGAP).

GMIP_MOUSE
θ value	1.47631e-18 (rank : 23)	NC score	0.798332 (rank : 5)
Query Neighborhood Hits	190	Target Neighborhood Hits	202	Shared Neighborhood Hits	71
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

FNBP2_HUMAN
θ value	1.92812e-18 (rank : 24)	NC score	0.707200 (rank : 35)
Query Neighborhood Hits	190	Target Neighborhood Hits	432	Shared Neighborhood Hits	102
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

SRGP2_MOUSE
θ value	4.29542e-18 (rank : 25)	NC score	0.716229 (rank : 32)
Query Neighborhood Hits	190	Target Neighborhood Hits	324	Shared Neighborhood Hits	100
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

RHG04_HUMAN
θ value	5.60996e-18 (rank : 26)	NC score	0.734895 (rank : 29)
Query Neighborhood Hits	190	Target Neighborhood Hits	307	Shared Neighborhood Hits	100
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RHG06_HUMAN
θ value	5.60996e-18 (rank : 27)	NC score	0.785582 (rank : 9)
Query Neighborhood Hits	190	Target Neighborhood Hits	114	Shared Neighborhood Hits	61
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

SRGP1_HUMAN
θ value	5.60996e-18 (rank : 28)	NC score	0.710152 (rank : 33)
Query Neighborhood Hits	190	Target Neighborhood Hits	390	Shared Neighborhood Hits	101
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

GMIP_HUMAN
θ value	7.32683e-18 (rank : 29)	NC score	0.790994 (rank : 7)
Query Neighborhood Hits	190	Target Neighborhood Hits	225	Shared Neighborhood Hits	68
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

RHG06_MOUSE
θ value	2.13179e-17 (rank : 30)	NC score	0.783382 (rank : 12)
Query Neighborhood Hits	190	Target Neighborhood Hits	105	Shared Neighborhood Hits	64
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG08_HUMAN
θ value	3.63628e-17 (rank : 31)	NC score	0.752006 (rank : 25)
Query Neighborhood Hits	190	Target Neighborhood Hits	88	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NSG0, O75983, O95695, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NVX8, Q9NXL1, Q9UH20	Gene names	ARHGAP8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

RGAP1_HUMAN
θ value	8.10077e-17 (rank : 32)	NC score	0.789096 (rank : 8)
Query Neighborhood Hits	190	Target Neighborhood Hits	189	Shared Neighborhood Hits	64
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RGAP1_MOUSE
θ value	1.80466e-16 (rank : 33)	NC score	0.785558 (rank : 10)
Query Neighborhood Hits	190	Target Neighborhood Hits	185	Shared Neighborhood Hits	64
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RHG18_HUMAN
θ value	1.80466e-16 (rank : 34)	NC score	0.771914 (rank : 17)
Query Neighborhood Hits	190	Target Neighborhood Hits	90	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

3BP1_MOUSE
θ value	2.35696e-16 (rank : 35)	NC score	0.794182 (rank : 6)
Query Neighborhood Hits	190	Target Neighborhood Hits	238	Shared Neighborhood Hits	62
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

RBP1_MOUSE
θ value	6.85773e-16 (rank : 36)	NC score	0.709410 (rank : 34)
Query Neighborhood Hits	190	Target Neighborhood Hits	493	Shared Neighborhood Hits	70
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RBP1_HUMAN
θ value	1.99529e-15 (rank : 37)	NC score	0.692559 (rank : 37)
Query Neighborhood Hits	190	Target Neighborhood Hits	521	Shared Neighborhood Hits	73
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RHG18_MOUSE
θ value	4.44505e-15 (rank : 38)	NC score	0.763882 (rank : 20)
Query Neighborhood Hits	190	Target Neighborhood Hits	110	Shared Neighborhood Hits	63
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

RHG25_MOUSE
θ value	4.44505e-15 (rank : 39)	NC score	0.706606 (rank : 36)
Query Neighborhood Hits	190	Target Neighborhood Hits	492	Shared Neighborhood Hits	75
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG07_HUMAN
θ value	9.90251e-15 (rank : 40)	NC score	0.673809 (rank : 43)
Query Neighborhood Hits	190	Target Neighborhood Hits	108	Shared Neighborhood Hits	61
SwissProt Accessions	Q96QB1, O14868, O43199, Q9C0E0	Gene names	DLC1, ARHGAP7, KIAA1723, STARD12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

RHG07_MOUSE
θ value	1.29331e-14 (rank : 41)	NC score	0.677718 (rank : 42)
Query Neighborhood Hits	190	Target Neighborhood Hits	103	Shared Neighborhood Hits	61
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

RHG08_MOUSE
θ value	1.29331e-14 (rank : 42)	NC score	0.750468 (rank : 26)
Query Neighborhood Hits	190	Target Neighborhood Hits	73	Shared Neighborhood Hits	61
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

CEND2_HUMAN
θ value	3.76295e-14 (rank : 43)	NC score	0.620711 (rank : 47)
Query Neighborhood Hits	190	Target Neighborhood Hits	166	Shared Neighborhood Hits	65
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

RHG25_HUMAN
θ value	8.38298e-14 (rank : 44)	NC score	0.681181 (rank : 41)
Query Neighborhood Hits	190	Target Neighborhood Hits	550	Shared Neighborhood Hits	74
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

CEND3_MOUSE
θ value	2.43908e-13 (rank : 45)	NC score	0.587450 (rank : 51)
Query Neighborhood Hits	190	Target Neighborhood Hits	228	Shared Neighborhood Hits	62
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CEND3_HUMAN
θ value	4.16044e-13 (rank : 46)	NC score	0.577671 (rank : 52)
Query Neighborhood Hits	190	Target Neighborhood Hits	275	Shared Neighborhood Hits	63
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

STA13_MOUSE
θ value	1.2105e-12 (rank : 47)	NC score	0.623281 (rank : 46)
Query Neighborhood Hits	190	Target Neighborhood Hits	89	Shared Neighborhood Hits	58
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

STA13_HUMAN
θ value	3.52202e-12 (rank : 48)	NC score	0.631003 (rank : 44)
Query Neighborhood Hits	190	Target Neighborhood Hits	89	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

TAGAP_HUMAN
θ value	1.33837e-11 (rank : 49)	NC score	0.690912 (rank : 39)
Query Neighborhood Hits	190	Target Neighborhood Hits	82	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

CEND1_MOUSE
θ value	2.98157e-11 (rank : 50)	NC score	0.530899 (rank : 54)
Query Neighborhood Hits	190	Target Neighborhood Hits	260	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CEND1_HUMAN
θ value	4.30538e-10 (rank : 51)	NC score	0.508949 (rank : 56)
Query Neighborhood Hits	190	Target Neighborhood Hits	284	Shared Neighborhood Hits	62
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CE005_HUMAN
θ value	9.59137e-10 (rank : 52)	NC score	0.611162 (rank : 49)
Query Neighborhood Hits	190	Target Neighborhood Hits	213	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

TAGAP_MOUSE
θ value	9.59137e-10 (rank : 53)	NC score	0.688320 (rank : 40)
Query Neighborhood Hits	190	Target Neighborhood Hits	83	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

CE005_MOUSE
θ value	1.63604e-09 (rank : 54)	NC score	0.607911 (rank : 50)
Query Neighborhood Hits	190	Target Neighborhood Hits	238	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

STAR8_MOUSE
θ value	1.63604e-09 (rank : 55)	NC score	0.627124 (rank : 45)
Query Neighborhood Hits	190	Target Neighborhood Hits	101	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STAR8_HUMAN
θ value	2.13673e-09 (rank : 56)	NC score	0.618585 (rank : 48)
Query Neighborhood Hits	190	Target Neighborhood Hits	216	Shared Neighborhood Hits	62
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

SPTB2_HUMAN
θ value	4.76016e-09 (rank : 57)	NC score	0.097810 (rank : 90)
Query Neighborhood Hits	190	Target Neighborhood Hits	748	Shared Neighborhood Hits	25
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

P85A_HUMAN
θ value	6.87365e-08 (rank : 58)	NC score	0.420703 (rank : 57)
Query Neighborhood Hits	190	Target Neighborhood Hits	479	Shared Neighborhood Hits	95
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	6.87365e-08 (rank : 59)	NC score	0.414974 (rank : 59)
Query Neighborhood Hits	190	Target Neighborhood Hits	435	Shared Neighborhood Hits	96
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SPTN4_HUMAN
θ value	6.87365e-08 (rank : 60)	NC score	0.106606 (rank : 84)
Query Neighborhood Hits	190	Target Neighborhood Hits	570	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

SPTB2_MOUSE
θ value	8.97725e-08 (rank : 61)	NC score	0.095985 (rank : 95)
Query Neighborhood Hits	190	Target Neighborhood Hits	770	Shared Neighborhood Hits	26
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

K1688_MOUSE
θ value	3.77169e-06 (rank : 62)	NC score	0.537178 (rank : 53)
Query Neighborhood Hits	190	Target Neighborhood Hits	188	Shared Neighborhood Hits	66
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

K1688_HUMAN
θ value	4.92598e-06 (rank : 63)	NC score	0.527560 (rank : 55)
Query Neighborhood Hits	190	Target Neighborhood Hits	217	Shared Neighborhood Hits	69
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

I5P2_HUMAN
θ value	4.1701e-05 (rank : 64)	NC score	0.329635 (rank : 61)
Query Neighborhood Hits	190	Target Neighborhood Hits	86	Shared Neighborhood Hits	51
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

SPTA2_HUMAN
θ value	5.44631e-05 (rank : 65)	NC score	0.118591 (rank : 70)
Query Neighborhood Hits	190	Target Neighborhood Hits	888	Shared Neighborhood Hits	56
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

ITCH_HUMAN
θ value	7.1131e-05 (rank : 66)	NC score	0.111773 (rank : 78)
Query Neighborhood Hits	190	Target Neighborhood Hits	162	Shared Neighborhood Hits	31
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

ITCH_MOUSE
θ value	0.000158464 (rank : 67)	NC score	0.113142 (rank : 74)
Query Neighborhood Hits	190	Target Neighborhood Hits	127	Shared Neighborhood Hits	32
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

YES_MOUSE
θ value	0.000270298 (rank : 68)	NC score	0.059359 (rank : 197)
Query Neighborhood Hits	190	Target Neighborhood Hits	1052	Shared Neighborhood Hits	62
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

PRP40_HUMAN
θ value	0.00035302 (rank : 69)	NC score	0.145486 (rank : 63)
Query Neighborhood Hits	190	Target Neighborhood Hits	442	Shared Neighborhood Hits	40
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

PRP40_MOUSE
θ value	0.000461057 (rank : 70)	NC score	0.142677 (rank : 65)
Query Neighborhood Hits	190	Target Neighborhood Hits	447	Shared Neighborhood Hits	38
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

WWP1_MOUSE
θ value	0.000602161 (rank : 71)	NC score	0.111169 (rank : 80)
Query Neighborhood Hits	190	Target Neighborhood Hits	138	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

YES_HUMAN
θ value	0.000602161 (rank : 72)	NC score	0.058023 (rank : 209)
Query Neighborhood Hits	190	Target Neighborhood Hits	1059	Shared Neighborhood Hits	62
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

SETD2_HUMAN
θ value	0.000786445 (rank : 73)	NC score	0.084294 (rank : 122)
Query Neighborhood Hits	190	Target Neighborhood Hits	412	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

WWP2_HUMAN
θ value	0.00102713 (rank : 74)	NC score	0.109883 (rank : 82)
Query Neighborhood Hits	190	Target Neighborhood Hits	177	Shared Neighborhood Hits	29
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP2_MOUSE
θ value	0.00102713 (rank : 75)	NC score	0.110192 (rank : 81)
Query Neighborhood Hits	190	Target Neighborhood Hits	118	Shared Neighborhood Hits	30
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

TIAM1_MOUSE
θ value	0.00134147 (rank : 76)	NC score	0.081361 (rank : 128)
Query Neighborhood Hits	190	Target Neighborhood Hits	205	Shared Neighborhood Hits	18
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

SPTN2_HUMAN
θ value	0.00298849 (rank : 77)	NC score	0.097478 (rank : 91)
Query Neighborhood Hits	190	Target Neighborhood Hits	535	Shared Neighborhood Hits	23
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

TIAM1_HUMAN
θ value	0.00298849 (rank : 78)	NC score	0.083424 (rank : 126)
Query Neighborhood Hits	190	Target Neighborhood Hits	225	Shared Neighborhood Hits	21
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

CRKL_HUMAN
θ value	0.00390308 (rank : 79)	NC score	0.125119 (rank : 67)
Query Neighborhood Hits	190	Target Neighborhood Hits	313	Shared Neighborhood Hits	59
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

SRC_HUMAN
θ value	0.00509761 (rank : 80)	NC score	0.055088 (rank : 229)
Query Neighborhood Hits	190	Target Neighborhood Hits	1058	Shared Neighborhood Hits	61
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

PLEK2_MOUSE
θ value	0.00665767 (rank : 81)	NC score	0.085727 (rank : 116)
Query Neighborhood Hits	190	Target Neighborhood Hits	96	Shared Neighborhood Hits	11
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

CRKL_MOUSE
θ value	0.00869519 (rank : 82)	NC score	0.120067 (rank : 69)
Query Neighborhood Hits	190	Target Neighborhood Hits	307	Shared Neighborhood Hits	60
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

FGR_HUMAN
θ value	0.00869519 (rank : 83)	NC score	0.058416 (rank : 203)
Query Neighborhood Hits	190	Target Neighborhood Hits	1067	Shared Neighborhood Hits	63
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SPTA1_MOUSE
θ value	0.0113563 (rank : 84)	NC score	0.120945 (rank : 68)
Query Neighborhood Hits	190	Target Neighborhood Hits	675	Shared Neighborhood Hits	66
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

FGR_MOUSE
θ value	0.0148317 (rank : 85)	NC score	0.058464 (rank : 201)
Query Neighborhood Hits	190	Target Neighborhood Hits	1069	Shared Neighborhood Hits	62
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

WWP1_HUMAN
θ value	0.0148317 (rank : 86)	NC score	0.109047 (rank : 83)
Query Neighborhood Hits	190	Target Neighborhood Hits	262	Shared Neighborhood Hits	30
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

YAP1_MOUSE
θ value	0.0148317 (rank : 87)	NC score	0.115527 (rank : 72)
Query Neighborhood Hits	190	Target Neighborhood Hits	96	Shared Neighborhood Hits	28
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

BTK_MOUSE
θ value	0.0193708 (rank : 88)	NC score	0.048998 (rank : 267)
Query Neighborhood Hits	190	Target Neighborhood Hits	1017	Shared Neighborhood Hits	55
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

FYN_HUMAN
θ value	0.0193708 (rank : 89)	NC score	0.053309 (rank : 239)
Query Neighborhood Hits	190	Target Neighborhood Hits	1078	Shared Neighborhood Hits	63
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	0.0193708 (rank : 90)	NC score	0.054808 (rank : 230)
Query Neighborhood Hits	190	Target Neighborhood Hits	1073	Shared Neighborhood Hits	62
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

TCRG1_HUMAN
θ value	0.0252991 (rank : 91)	NC score	0.095495 (rank : 96)
Query Neighborhood Hits	190	Target Neighborhood Hits	929	Shared Neighborhood Hits	43
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

AHI1_HUMAN
θ value	0.0330416 (rank : 92)	NC score	0.075417 (rank : 142)
Query Neighborhood Hits	190	Target Neighborhood Hits	537	Shared Neighborhood Hits	51
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

BTK_HUMAN
θ value	0.0330416 (rank : 93)	NC score	0.049334 (rank : 266)
Query Neighborhood Hits	190	Target Neighborhood Hits	1026	Shared Neighborhood Hits	56
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

ITK_HUMAN
θ value	0.0330416 (rank : 94)	NC score	0.045250 (rank : 274)
Query Neighborhood Hits	190	Target Neighborhood Hits	1016	Shared Neighborhood Hits	53
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

MPP2_HUMAN
θ value	0.0330416 (rank : 95)	NC score	0.049610 (rank : 265)
Query Neighborhood Hits	190	Target Neighborhood Hits	173	Shared Neighborhood Hits	27
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

TCRG1_MOUSE
θ value	0.0330416 (rank : 96)	NC score	0.095009 (rank : 98)
Query Neighborhood Hits	190	Target Neighborhood Hits	947	Shared Neighborhood Hits	44
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

CHD2_HUMAN
θ value	0.0736092 (rank : 97)	NC score	0.015447 (rank : 300)
Query Neighborhood Hits	190	Target Neighborhood Hits	360	Shared Neighborhood Hits	11
SwissProt Accessions	O14647	Gene names	CHD2
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 2 (EC 3.6.1.-) (ATP- dependent helicase CHD2) (CHD-2).

SMUF2_HUMAN
θ value	0.0736092 (rank : 98)	NC score	0.092715 (rank : 101)
Query Neighborhood Hits	190	Target Neighborhood Hits	142	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SPTA1_HUMAN
θ value	0.0736092 (rank : 99)	NC score	0.111348 (rank : 79)
Query Neighborhood Hits	190	Target Neighborhood Hits	748	Shared Neighborhood Hits	58
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

MPP6_HUMAN
θ value	0.0961366 (rank : 100)	NC score	0.061057 (rank : 181)
Query Neighborhood Hits	190	Target Neighborhood Hits	180	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

PLEK2_HUMAN
θ value	0.0961366 (rank : 101)	NC score	0.074351 (rank : 147)
Query Neighborhood Hits	190	Target Neighborhood Hits	101	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PSD3_HUMAN
θ value	0.0961366 (rank : 102)	NC score	0.064733 (rank : 174)
Query Neighborhood Hits	190	Target Neighborhood Hits	75	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

NED4L_HUMAN
θ value	0.125558 (rank : 103)	NC score	0.086228 (rank : 113)
Query Neighborhood Hits	190	Target Neighborhood Hits	238	Shared Neighborhood Hits	33
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

SPTN5_HUMAN
θ value	0.125558 (rank : 104)	NC score	0.082159 (rank : 127)
Query Neighborhood Hits	190	Target Neighborhood Hits	674	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

GAS7_HUMAN
θ value	0.163984 (rank : 105)	NC score	0.099598 (rank : 89)
Query Neighborhood Hits	190	Target Neighborhood Hits	258	Shared Neighborhood Hits	36
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

NED4L_MOUSE
θ value	0.163984 (rank : 106)	NC score	0.085720 (rank : 117)
Query Neighborhood Hits	190	Target Neighborhood Hits	231	Shared Neighborhood Hits	32
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

K1914_HUMAN
θ value	0.21417 (rank : 107)	NC score	0.048280 (rank : 270)
Query Neighborhood Hits	190	Target Neighborhood Hits	255	Shared Neighborhood Hits	13
SwissProt Accessions	Q8N4X5, Q8TB54, Q96PX4, Q96SY5	Gene names	KIAA1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

YAP1_HUMAN
θ value	0.21417 (rank : 108)	NC score	0.094919 (rank : 99)
Query Neighborhood Hits	190	Target Neighborhood Hits	173	Shared Neighborhood Hits	29
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

CSPG2_MOUSE
θ value	0.279714 (rank : 109)	NC score	0.011599 (rank : 311)
Query Neighborhood Hits	190	Target Neighborhood Hits	711	Shared Neighborhood Hits	8
SwissProt Accessions	Q62059, Q62058, Q9CUU0	Gene names	Cspg2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M).

FA44A_HUMAN
θ value	0.279714 (rank : 110)	NC score	0.024906 (rank : 291)
Query Neighborhood Hits	190	Target Neighborhood Hits	280	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NFC6, Q6P0M8	Gene names	FAM44A
Domain Architecture	No domain graphic available
Description	Protein FAM44A.

ITK_MOUSE
θ value	0.279714 (rank : 111)	NC score	0.040020 (rank : 286)
Query Neighborhood Hits	190	Target Neighborhood Hits	985	Shared Neighborhood Hits	49
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

MPP2_MOUSE
θ value	0.279714 (rank : 112)	NC score	0.045304 (rank : 273)
Query Neighborhood Hits	190	Target Neighborhood Hits	189	Shared Neighborhood Hits	28
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

PTMS_HUMAN
θ value	0.279714 (rank : 113)	NC score	0.048482 (rank : 268)
Query Neighborhood Hits	190	Target Neighborhood Hits	111	Shared Neighborhood Hits	5
SwissProt Accessions	P20962	Gene names	PTMS
Domain Architecture	No domain graphic available
Description	Parathymosin.

GAS7_MOUSE
θ value	0.365318 (rank : 114)	NC score	0.103537 (rank : 87)
Query Neighborhood Hits	190	Target Neighborhood Hits	259	Shared Neighborhood Hits	35
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

RPTN_MOUSE
θ value	0.365318 (rank : 115)	NC score	0.015110 (rank : 302)
Query Neighborhood Hits	190	Target Neighborhood Hits	650	Shared Neighborhood Hits	15
SwissProt Accessions	P97347	Gene names	Rptn
Domain Architecture
Description	Repetin.

TEC_HUMAN
θ value	0.365318 (rank : 116)	NC score	0.042529 (rank : 278)
Query Neighborhood Hits	190	Target Neighborhood Hits	1006	Shared Neighborhood Hits	54
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

HMBX1_HUMAN
θ value	0.47712 (rank : 117)	NC score	0.040257 (rank : 284)
Query Neighborhood Hits	190	Target Neighborhood Hits	118	Shared Neighborhood Hits	4
SwissProt Accessions	Q6NT76, Q3Y6P1, Q96GS5, Q9H701	Gene names	HMBOX1
Domain Architecture	No domain graphic available
Description	Homeobox-containing protein 1.

SRC_MOUSE
θ value	0.47712 (rank : 118)	NC score	0.045658 (rank : 272)
Query Neighborhood Hits	190	Target Neighborhood Hits	1033	Shared Neighborhood Hits	57
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

TEC_MOUSE
θ value	0.47712 (rank : 119)	NC score	0.042162 (rank : 279)
Query Neighborhood Hits	190	Target Neighborhood Hits	1006	Shared Neighborhood Hits	56
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

HMBX1_MOUSE
θ value	0.62314 (rank : 120)	NC score	0.038767 (rank : 288)
Query Neighborhood Hits	190	Target Neighborhood Hits	117	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BJA3, Q80WC2, Q8BWE7, Q99LV1	Gene names	Hmbox1
Domain Architecture	No domain graphic available
Description	Homeobox-containing protein 1.

NEDD4_MOUSE
θ value	0.62314 (rank : 121)	NC score	0.084275 (rank : 123)
Query Neighborhood Hits	190	Target Neighborhood Hits	212	Shared Neighborhood Hits	31
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

P85B_HUMAN
θ value	0.62314 (rank : 122)	NC score	0.145149 (rank : 64)
Query Neighborhood Hits	190	Target Neighborhood Hits	543	Shared Neighborhood Hits	59
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

HCK_MOUSE
θ value	0.813845 (rank : 123)	NC score	0.041116 (rank : 282)
Query Neighborhood Hits	190	Target Neighborhood Hits	1029	Shared Neighborhood Hits	51
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

MPP6_MOUSE
θ value	0.813845 (rank : 124)	NC score	0.056592 (rank : 215)
Query Neighborhood Hits	190	Target Neighborhood Hits	187	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

VINEX_MOUSE
θ value	0.813845 (rank : 125)	NC score	0.106421 (rank : 85)
Query Neighborhood Hits	190	Target Neighborhood Hits	286	Shared Neighborhood Hits	52
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

MAGI1_HUMAN
θ value	1.06291 (rank : 126)	NC score	0.048472 (rank : 269)
Query Neighborhood Hits	190	Target Neighborhood Hits	388	Shared Neighborhood Hits	37
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MYO10_HUMAN
θ value	1.06291 (rank : 127)	NC score	0.053799 (rank : 234)
Query Neighborhood Hits	190	Target Neighborhood Hits	920	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

PGCA_MOUSE
θ value	1.06291 (rank : 128)	NC score	0.010241 (rank : 315)
Query Neighborhood Hits	190	Target Neighborhood Hits	643	Shared Neighborhood Hits	7
SwissProt Accessions	Q61282, Q64021	Gene names	Agc1, Agc
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP).

RCOR1_HUMAN
θ value	1.06291 (rank : 129)	NC score	0.024674 (rank : 292)
Query Neighborhood Hits	190	Target Neighborhood Hits	61	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UKL0, Q15044, Q6P2I9, Q86VG5	Gene names	RCOR1, KIAA0071, RCOR
Domain Architecture	No domain graphic available
Description	REST corepressor 1 (Protein CoREST).

RCOR1_MOUSE
θ value	1.06291 (rank : 130)	NC score	0.024094 (rank : 293)
Query Neighborhood Hits	190	Target Neighborhood Hits	55	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CFE3, Q3V092, Q8BK28, Q8CHI2	Gene names	Rcor1, D12Wsu95e, Kiaa0071
Domain Architecture	No domain graphic available
Description	REST corepressor 1 (Protein CoREST).

TTK_MOUSE
θ value	1.06291 (rank : 131)	NC score	0.006292 (rank : 319)
Query Neighborhood Hits	190	Target Neighborhood Hits	803	Shared Neighborhood Hits	22
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

WBP4_MOUSE
θ value	1.06291 (rank : 132)	NC score	0.084388 (rank : 120)
Query Neighborhood Hits	190	Target Neighborhood Hits	100	Shared Neighborhood Hits	28
SwissProt Accessions	Q61048, Q8K1Z9, Q9CS45	Gene names	Wbp4, Fbp21, Fnbp21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

WWTR1_HUMAN
θ value	1.06291 (rank : 133)	NC score	0.078277 (rank : 137)
Query Neighborhood Hits	190	Target Neighborhood Hits	76	Shared Neighborhood Hits	23
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

ITSN1_MOUSE
θ value	1.38821 (rank : 134)	NC score	0.081236 (rank : 129)
Query Neighborhood Hits	190	Target Neighborhood Hits	1669	Shared Neighborhood Hits	93
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

MAGI2_MOUSE
θ value	1.38821 (rank : 135)	NC score	0.049909 (rank : 264)
Query Neighborhood Hits	190	Target Neighborhood Hits	370	Shared Neighborhood Hits	32
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

SH24A_MOUSE
θ value	1.38821 (rank : 136)	NC score	0.032713 (rank : 290)
Query Neighborhood Hits	190	Target Neighborhood Hits	326	Shared Neighborhood Hits	25
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SP100_MOUSE
θ value	1.38821 (rank : 137)	NC score	0.019048 (rank : 295)
Query Neighborhood Hits	190	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	O35892, O35897, O88392, O88395	Gene names	Sp100
Domain Architecture
Description	Nuclear autoantigen Sp-100 (Speckled 100 kDa) (Nuclear dot-associated Sp100 protein).

TXK_HUMAN
θ value	1.38821 (rank : 138)	NC score	0.041831 (rank : 281)
Query Neighborhood Hits	190	Target Neighborhood Hits	971	Shared Neighborhood Hits	54
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

BLK_HUMAN
θ value	2.36792 (rank : 139)	NC score	0.039313 (rank : 287)
Query Neighborhood Hits	190	Target Neighborhood Hits	994	Shared Neighborhood Hits	50
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

ES8L3_MOUSE
θ value	2.36792 (rank : 140)	NC score	0.046451 (rank : 271)
Query Neighborhood Hits	190	Target Neighborhood Hits	168	Shared Neighborhood Hits	38
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

HCK_HUMAN
θ value	2.36792 (rank : 141)	NC score	0.041834 (rank : 280)
Query Neighborhood Hits	190	Target Neighborhood Hits	1035	Shared Neighborhood Hits	53
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

NEDD4_HUMAN
θ value	2.36792 (rank : 142)	NC score	0.088402 (rank : 108)
Query Neighborhood Hits	190	Target Neighborhood Hits	214	Shared Neighborhood Hits	30
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

AHI1_MOUSE
θ value	3.0926 (rank : 143)	NC score	0.068503 (rank : 164)
Query Neighborhood Hits	190	Target Neighborhood Hits	496	Shared Neighborhood Hits	51
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

CSKP_HUMAN
θ value	3.0926 (rank : 144)	NC score	0.012902 (rank : 308)
Query Neighborhood Hits	190	Target Neighborhood Hits	1022	Shared Neighborhood Hits	46
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

ELOA1_HUMAN
θ value	3.0926 (rank : 145)	NC score	0.014562 (rank : 305)
Query Neighborhood Hits	190	Target Neighborhood Hits	388	Shared Neighborhood Hits	16
SwissProt Accessions	Q14241, Q8IXH1	Gene names	TCEB3
Domain Architecture
Description	Transcription elongation factor B polypeptide 3 (RNA polymerase II transcription factor SIII subunit A1) (SIII p110) (Elongin-A) (EloA) (Elongin 110 kDa subunit).

FHOD1_HUMAN
θ value	3.0926 (rank : 146)	NC score	0.011928 (rank : 310)
Query Neighborhood Hits	190	Target Neighborhood Hits	184	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y613, Q59F76, Q6Y1F2, Q76MS8, Q8N521	Gene names	FHOD1, FHOS
Domain Architecture
Description	FH1/FH2 domain-containing protein (Formin homolog overexpressed in spleen) (FHOS) (Formin homology 2 domain-containing protein 1).

K1914_MOUSE
θ value	3.0926 (rank : 147)	NC score	0.043442 (rank : 276)
Query Neighborhood Hits	190	Target Neighborhood Hits	216	Shared Neighborhood Hits	12
SwissProt Accessions	Q5DTU0, Q8BID1, Q8K2G0	Gene names	Kiaa1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

NCK2_HUMAN
θ value	3.0926 (rank : 148)	NC score	0.126380 (rank : 66)
Query Neighborhood Hits	190	Target Neighborhood Hits	310	Shared Neighborhood Hits	53
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

SEM6A_MOUSE
θ value	3.0926 (rank : 149)	NC score	0.004816 (rank : 324)
Query Neighborhood Hits	190	Target Neighborhood Hits	96	Shared Neighborhood Hits	4
SwissProt Accessions	O35464, Q6P5A8, Q6PCN9, Q9EQ71	Gene names	Sema6a, Semaq
Domain Architecture
Description	Semaphorin-6A precursor (Semaphorin VIA) (Sema VIA) (Semaphorin 6A-1) (SEMA6A-1) (Semaphorin Q) (Sema Q).

WBP4_HUMAN
θ value	3.0926 (rank : 150)	NC score	0.068825 (rank : 163)
Query Neighborhood Hits	190	Target Neighborhood Hits	86	Shared Neighborhood Hits	21
SwissProt Accessions	O75554	Gene names	WBP4, FBP21, FNBP21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

BLK_MOUSE
θ value	4.03905 (rank : 151)	NC score	0.040238 (rank : 285)
Query Neighborhood Hits	190	Target Neighborhood Hits	992	Shared Neighborhood Hits	50
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CB013_MOUSE
θ value	4.03905 (rank : 152)	NC score	0.013097 (rank : 307)
Query Neighborhood Hits	190	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D842, Q8BZL5, Q99LX6	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf13 homolog.

CSKI2_MOUSE
θ value	4.03905 (rank : 153)	NC score	0.014690 (rank : 304)
Query Neighborhood Hits	190	Target Neighborhood Hits	812	Shared Neighborhood Hits	19
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

DACT1_HUMAN
θ value	4.03905 (rank : 154)	NC score	0.014883 (rank : 303)
Query Neighborhood Hits	190	Target Neighborhood Hits	228	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NYF0, Q86TY0	Gene names	DACT1, DPR1, HNG3
Domain Architecture	No domain graphic available
Description	Dapper homolog 1 (hDPR1) (Heptacellular carcinoma novel gene 3 protein).

IQGA1_HUMAN
θ value	4.03905 (rank : 155)	NC score	0.018853 (rank : 296)
Query Neighborhood Hits	190	Target Neighborhood Hits	250	Shared Neighborhood Hits	14
SwissProt Accessions	P46940	Gene names	IQGAP1, KIAA0051
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP1 (p195).

LRIG2_HUMAN
θ value	4.03905 (rank : 156)	NC score	-0.002649 (rank : 332)
Query Neighborhood Hits	190	Target Neighborhood Hits	595	Shared Neighborhood Hits	4
SwissProt Accessions	O94898, Q9NSN2	Gene names	LRIG2, KIAA0806, LIG2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor (LIG-2).

MYT1_MOUSE
θ value	4.03905 (rank : 157)	NC score	0.007507 (rank : 318)
Query Neighborhood Hits	190	Target Neighborhood Hits	385	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CFC2, O08995, Q8CFH1	Gene names	Myt1, Kiaa0835, Nzf2
Domain Architecture	No domain graphic available
Description	Myelin transcription factor 1 (MyT1) (Neural zinc finger factor 2) (NZF-2).

NAPSA_HUMAN
θ value	4.03905 (rank : 158)	NC score	0.005825 (rank : 322)
Query Neighborhood Hits	190	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	O96009	Gene names	NAPSA, NAP1
Domain Architecture
Description	Napsin-A precursor (EC 3.4.23.-) (Napsin-1) (NAPA) (TA01/TA02) (Aspartyl protease 4) (Asp 4) (ASP4).

PRP4B_HUMAN
θ value	4.03905 (rank : 159)	NC score	0.012686 (rank : 309)
Query Neighborhood Hits	190	Target Neighborhood Hits	1030	Shared Neighborhood Hits	34
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

T4S5_HUMAN
θ value	4.03905 (rank : 160)	NC score	0.024054 (rank : 294)
Query Neighborhood Hits	190	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	O14894, Q6IB79	Gene names	TM4SF5
Domain Architecture
Description	Transmembrane 4 L6 family member 5 (Tetraspan transmembrane protein L6H).

TXK_MOUSE
θ value	4.03905 (rank : 161)	NC score	0.040879 (rank : 283)
Query Neighborhood Hits	190	Target Neighborhood Hits	980	Shared Neighborhood Hits	56
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

CSKP_MOUSE
θ value	5.27518 (rank : 162)	NC score	0.011408 (rank : 312)
Query Neighborhood Hits	190	Target Neighborhood Hits	1027	Shared Neighborhood Hits	44
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

CYLC1_HUMAN
θ value	5.27518 (rank : 163)	NC score	0.010728 (rank : 314)
Query Neighborhood Hits	190	Target Neighborhood Hits	408	Shared Neighborhood Hits	16
SwissProt Accessions	P35663, Q5JQQ9	Gene names	CYLC1, CYL, CYL1
Domain Architecture	No domain graphic available
Description	Cylicin-1 (Cylicin I) (Multiple-band polypeptide I).

EM55_MOUSE
θ value	5.27518 (rank : 164)	NC score	0.034471 (rank : 289)
Query Neighborhood Hits	190	Target Neighborhood Hits	221	Shared Neighborhood Hits	29
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

MAGI2_HUMAN
θ value	5.27518 (rank : 165)	NC score	0.043068 (rank : 277)
Query Neighborhood Hits	190	Target Neighborhood Hits	373	Shared Neighborhood Hits	29
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MYST4_HUMAN
θ value	5.27518 (rank : 166)	NC score	0.005098 (rank : 323)
Query Neighborhood Hits	190	Target Neighborhood Hits	671	Shared Neighborhood Hits	13
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

P85B_MOUSE
θ value	5.27518 (rank : 167)	NC score	0.112223 (rank : 77)
Query Neighborhood Hits	190	Target Neighborhood Hits	519	Shared Neighborhood Hits	57
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SEM6A_HUMAN
θ value	5.27518 (rank : 168)	NC score	0.004182 (rank : 327)
Query Neighborhood Hits	190	Target Neighborhood Hits	96	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H2E6, Q9P2H9	Gene names	SEMA6A, KIAA1368
Domain Architecture
Description	Semaphorin-6A precursor (Semaphorin VIA) (Sema VIA) (Semaphorin 6A-1) (SEMA6A-1).

SM1L2_MOUSE
θ value	5.27518 (rank : 169)	NC score	0.010845 (rank : 313)
Query Neighborhood Hits	190	Target Neighborhood Hits	918	Shared Neighborhood Hits	24
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

CENPE_HUMAN
θ value	6.88961 (rank : 170)	NC score	0.018006 (rank : 297)
Query Neighborhood Hits	190	Target Neighborhood Hits	2060	Shared Neighborhood Hits	53
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

DACT1_MOUSE
θ value	6.88961 (rank : 171)	NC score	0.015954 (rank : 299)
Query Neighborhood Hits	190	Target Neighborhood Hits	93	Shared Neighborhood Hits	7
SwissProt Accessions	Q8R4A3, Q80VG9, Q8BP49, Q9JK89	Gene names	Dact1, Thyex3
Domain Architecture	No domain graphic available
Description	Dapper homolog 1 (MDpr1) (Frodo) (Thymus-expressed novel gene 3 protein).

HBP1_HUMAN
θ value	6.88961 (rank : 172)	NC score	0.004627 (rank : 325)
Query Neighborhood Hits	190	Target Neighborhood Hits	89	Shared Neighborhood Hits	2
SwissProt Accessions	O60381, Q8TBM1, Q8TE93, Q96AJ2	Gene names	HBP1
Domain Architecture	No domain graphic available
Description	HMG box-containing protein 1 (HMG box transcription factor 1) (High mobility group box transcription factor 1).

ITSN1_HUMAN
θ value	6.88961 (rank : 173)	NC score	0.079858 (rank : 133)
Query Neighborhood Hits	190	Target Neighborhood Hits	1757	Shared Neighborhood Hits	95
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

LAP2_MOUSE
θ value	6.88961 (rank : 174)	NC score	0.000963 (rank : 330)
Query Neighborhood Hits	190	Target Neighborhood Hits	482	Shared Neighborhood Hits	10
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

MB3L2_HUMAN
θ value	6.88961 (rank : 175)	NC score	0.009843 (rank : 316)
Query Neighborhood Hits	190	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NHZ7	Gene names	MBD3L2
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 3-like 2 (MBD3-like 2).

PALM_MOUSE
θ value	6.88961 (rank : 176)	NC score	0.014537 (rank : 306)
Query Neighborhood Hits	190	Target Neighborhood Hits	228	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Z0P4, Q9Z0P3	Gene names	Palm
Domain Architecture
Description	Paralemmin.

SRBS1_MOUSE
θ value	6.88961 (rank : 177)	NC score	0.091300 (rank : 102)
Query Neighborhood Hits	190	Target Neighborhood Hits	409	Shared Neighborhood Hits	57
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

UBP31_HUMAN
θ value	6.88961 (rank : 178)	NC score	0.006163 (rank : 321)
Query Neighborhood Hits	190	Target Neighborhood Hits	293	Shared Neighborhood Hits	8
SwissProt Accessions	Q70CQ4, Q6AW97, Q6ZTC0, Q6ZTN2, Q9ULL7	Gene names	USP31, KIAA1203
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.1.2.15) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) (Deubiquitinating enzyme 31).

VINEX_HUMAN
θ value	6.88961 (rank : 179)	NC score	0.101409 (rank : 88)
Query Neighborhood Hits	190	Target Neighborhood Hits	270	Shared Neighborhood Hits	53
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VP13B_HUMAN
θ value	6.88961 (rank : 180)	NC score	0.015286 (rank : 301)
Query Neighborhood Hits	190	Target Neighborhood Hits	78	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z7G8, Q709C6, Q709C7, Q7Z7G4, Q7Z7G5, Q7Z7G6, Q7Z7G7, Q8NB77, Q9NWV1, Q9Y4E7	Gene names	VPS13B, CHS1, COH1, KIAA0532
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associated protein 13B (Cohen syndrome protein 1).

ARI1B_HUMAN
θ value	8.99809 (rank : 181)	NC score	0.016456 (rank : 298)
Query Neighborhood Hits	190	Target Neighborhood Hits	567	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

KS6C1_MOUSE
θ value	8.99809 (rank : 182)	NC score	0.000021 (rank : 331)
Query Neighborhood Hits	190	Target Neighborhood Hits	700	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

LEPR_MOUSE
θ value	8.99809 (rank : 183)	NC score	0.003913 (rank : 329)
Query Neighborhood Hits	190	Target Neighborhood Hits	109	Shared Neighborhood Hits	2
SwissProt Accessions	P48356, O35686, O54986, Q61215, Q64309, Q9QWG3, Q9QWV5	Gene names	Lepr, db, Obr
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (B219) (CD295 antigen).

MAGI1_MOUSE
θ value	8.99809 (rank : 184)	NC score	0.044842 (rank : 275)
Query Neighborhood Hits	190	Target Neighborhood Hits	403	Shared Neighborhood Hits	37
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MKL2_MOUSE
θ value	8.99809 (rank : 185)	NC score	0.004012 (rank : 328)
Query Neighborhood Hits	190	Target Neighborhood Hits	269	Shared Neighborhood Hits	7
SwissProt Accessions	P59759	Gene names	Mkl2, Mrtfb
Domain Architecture
Description	MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B).

OPA1_MOUSE
θ value	8.99809 (rank : 186)	NC score	0.004513 (rank : 326)
Query Neighborhood Hits	190	Target Neighborhood Hits	79	Shared Neighborhood Hits	4
SwissProt Accessions	P58281, Q3ULA5, Q8BKU7, Q8BLL3, Q8BM08, Q8R3J7	Gene names	Opa1
Domain Architecture
Description	Dynamin-like 120 kDa protein, mitochondrial precursor (Optic atrophy protein 1 homolog) (Large GTP-binding protein) (LargeG) [Contains: Dynamin-like 120 kDa protein, form S1].

PCNT_MOUSE
θ value	8.99809 (rank : 187)	NC score	0.009375 (rank : 317)
Query Neighborhood Hits	190	Target Neighborhood Hits	1207	Shared Neighborhood Hits	19
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

SLAP2_MOUSE
θ value	8.99809 (rank : 188)	NC score	0.088847 (rank : 106)
Query Neighborhood Hits	190	Target Neighborhood Hits	136	Shared Neighborhood Hits	37
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SRBS1_HUMAN
θ value	8.99809 (rank : 189)	NC score	0.096360 (rank : 94)
Query Neighborhood Hits	190	Target Neighborhood Hits	396	Shared Neighborhood Hits	60
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

TTC28_MOUSE
θ value	8.99809 (rank : 190)	NC score	0.006224 (rank : 320)
Query Neighborhood Hits	190	Target Neighborhood Hits	194	Shared Neighborhood Hits	8
SwissProt Accessions	Q80XJ3, Q6P9J6, Q80TL5, Q8BV10, Q8C0F2	Gene names	Ttc28, Kiaa1043
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

ABI1_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.052492 (rank : 247)
Query Neighborhood Hits	190	Target Neighborhood Hits	257	Shared Neighborhood Hits	42
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 192)	NC score	0.059871 (rank : 190)
Query Neighborhood Hits	190	Target Neighborhood Hits	246	Shared Neighborhood Hits	42
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.068854 (rank : 162)
Query Neighborhood Hits	190	Target Neighborhood Hits	350	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 194)	NC score	0.070452 (rank : 160)
Query Neighborhood Hits	190	Target Neighborhood Hits	266	Shared Neighborhood Hits	44
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ACTN1_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.051428 (rank : 259)
Query Neighborhood Hits	190	Target Neighborhood Hits	221	Shared Neighborhood Hits	8
SwissProt Accessions	P12814, Q9BTN1	Gene names	ACTN1
Domain Architecture
Description	Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (Non-muscle alpha-actinin-1) (F-actin cross-linking protein).

ACTN1_MOUSE
θ value	θ > 10 (rank : 196)	NC score	0.051655 (rank : 255)
Query Neighborhood Hits	190	Target Neighborhood Hits	216	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TPR4	Gene names	Actn1
Domain Architecture
Description	Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (Non-muscle alpha-actinin-1) (F-actin cross-linking protein).

ACTN3_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.052318 (rank : 250)
Query Neighborhood Hits	190	Target Neighborhood Hits	272	Shared Neighborhood Hits	12
SwissProt Accessions	Q08043	Gene names	ACTN3
Domain Architecture
Description	Alpha-actinin-3 (Alpha actinin skeletal muscle isoform 3) (F-actin cross-linking protein).

ACTN3_MOUSE
θ value	θ > 10 (rank : 198)	NC score	0.051638 (rank : 256)
Query Neighborhood Hits	190	Target Neighborhood Hits	265	Shared Neighborhood Hits	9
SwissProt Accessions	O88990	Gene names	Actn3
Domain Architecture
Description	Alpha-actinin-3 (Alpha actinin skeletal muscle isoform 3) (F-actin cross-linking protein).

ACTN4_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.051847 (rank : 254)
Query Neighborhood Hits	190	Target Neighborhood Hits	279	Shared Neighborhood Hits	11
SwissProt Accessions	O43707, O76048	Gene names	ACTN4
Domain Architecture
Description	Alpha-actinin-4 (Non-muscle alpha-actinin 4) (F-actin cross-linking protein).

ACTN4_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.051859 (rank : 253)
Query Neighborhood Hits	190	Target Neighborhood Hits	276	Shared Neighborhood Hits	13
SwissProt Accessions	P57780	Gene names	Actn4
Domain Architecture
Description	Alpha-actinin-4 (Non-muscle alpha-actinin 4) (F-actin cross-linking protein).

ANM2_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.063992 (rank : 176)
Query Neighborhood Hits	190	Target Neighborhood Hits	175	Shared Neighborhood Hits	41
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.064685 (rank : 175)
Query Neighborhood Hits	190	Target Neighborhood Hits	175	Shared Neighborhood Hits	41
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHG4_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.060163 (rank : 187)
Query Neighborhood Hits	190	Target Neighborhood Hits	242	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG6_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.056253 (rank : 220)
Query Neighborhood Hits	190	Target Neighborhood Hits	376	Shared Neighborhood Hits	51
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	θ > 10 (rank : 205)	NC score	0.057631 (rank : 211)
Query Neighborhood Hits	190	Target Neighborhood Hits	394	Shared Neighborhood Hits	52
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG7_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.065225 (rank : 171)
Query Neighborhood Hits	190	Target Neighborhood Hits	347	Shared Neighborhood Hits	52
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
θ value	θ > 10 (rank : 207)	NC score	0.074537 (rank : 146)
Query Neighborhood Hits	190	Target Neighborhood Hits	396	Shared Neighborhood Hits	54
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG9_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.060218 (rank : 186)
Query Neighborhood Hits	190	Target Neighborhood Hits	235	Shared Neighborhood Hits	40
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.060410 (rank : 185)
Query Neighborhood Hits	190	Target Neighborhood Hits	234	Shared Neighborhood Hits	40
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ATCAY_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.052031 (rank : 252)
Query Neighborhood Hits	190	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q86WG3, Q8NAQ2, Q8TAQ3, Q96HC6, Q96JF5	Gene names	ATCAY, KIAA1872
Domain Architecture
Description	Caytaxin (Ataxia Cayman type protein) (BNIP-H).

ATCAY_MOUSE
θ value	θ > 10 (rank : 211)	NC score	0.052527 (rank : 246)
Query Neighborhood Hits	190	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BHE3, Q3TR94	Gene names	Atcay
Domain Architecture
Description	Caytaxin.

BNIP2_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.055170 (rank : 226)
Query Neighborhood Hits	190	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q12982	Gene names	BNIP2, NIP2
Domain Architecture
Description	BCL2/adenovirus E1B 19 kDa protein-interacting protein 2.

BNIP2_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.055128 (rank : 227)
Query Neighborhood Hits	190	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	O54940	Gene names	Bnip2, Nip2l
Domain Architecture
Description	BCL2/adenovirus E1B 19 kDa protein-interacting protein 2.

BNIPL_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.050689 (rank : 262)
Query Neighborhood Hits	190	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z465, Q6DK43, Q8TCY7, Q8WYG2	Gene names	BNIPL
Domain Architecture	No domain graphic available
Description	Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein.

BNIPL_MOUSE
θ value	θ > 10 (rank : 215)	NC score	0.050913 (rank : 261)
Query Neighborhood Hits	190	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q99JU7, Q923E3	Gene names	Bnipl
Domain Architecture	No domain graphic available
Description	Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein.

CD2AP_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.079740 (rank : 134)
Query Neighborhood Hits	190	Target Neighborhood Hits	315	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 217)	NC score	0.071535 (rank : 159)
Query Neighborhood Hits	190	Target Neighborhood Hits	336	Shared Neighborhood Hits	52
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CENA2_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.051478 (rank : 258)
Query Neighborhood Hits	190	Target Neighborhood Hits	83	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

CENB1_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.074541 (rank : 145)
Query Neighborhood Hits	190	Target Neighborhood Hits	383	Shared Neighborhood Hits	15
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

CENB2_HUMAN
θ value	θ > 10 (rank : 220)	NC score	0.077855 (rank : 138)
Query Neighborhood Hits	190	Target Neighborhood Hits	425	Shared Neighborhood Hits	18
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENB5_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.074090 (rank : 148)
Query Neighborhood Hits	190	Target Neighborhood Hits	395	Shared Neighborhood Hits	14
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CIP4_HUMAN
θ value	θ > 10 (rank : 222)	NC score	0.084316 (rank : 121)
Query Neighborhood Hits	190	Target Neighborhood Hits	374	Shared Neighborhood Hits	43
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CRK_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.086928 (rank : 112)
Query Neighborhood Hits	190	Target Neighborhood Hits	308	Shared Neighborhood Hits	56
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 224)	NC score	0.086202 (rank : 114)
Query Neighborhood Hits	190	Target Neighborhood Hits	314	Shared Neighborhood Hits	56
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

DAPP1_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.087803 (rank : 110)
Query Neighborhood Hits	190	Target Neighborhood Hits	227	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.089038 (rank : 105)
Query Neighborhood Hits	190	Target Neighborhood Hits	225	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DDEF1_MOUSE
θ value	θ > 10 (rank : 227)	NC score	0.058165 (rank : 206)
Query Neighborhood Hits	190	Target Neighborhood Hits	592	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_HUMAN
θ value	θ > 10 (rank : 228)	NC score	0.065908 (rank : 169)
Query Neighborhood Hits	190	Target Neighborhood Hits	599	Shared Neighborhood Hits	44
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	θ > 10 (rank : 229)	NC score	0.061156 (rank : 180)
Query Neighborhood Hits	190	Target Neighborhood Hits	625	Shared Neighborhood Hits	39
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DNMBP_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.080719 (rank : 131)
Query Neighborhood Hits	190	Target Neighborhood Hits	413	Shared Neighborhood Hits	60
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
θ value	θ > 10 (rank : 231)	NC score	0.073230 (rank : 152)
Query Neighborhood Hits	190	Target Neighborhood Hits	435	Shared Neighborhood Hits	57
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DP13A_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.052324 (rank : 249)
Query Neighborhood Hits	190	Target Neighborhood Hits	107	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

FA13A_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.052719 (rank : 244)
Query Neighborhood Hits	190	Target Neighborhood Hits	102	Shared Neighborhood Hits	2
SwissProt Accessions	O94988, Q8NBA3	Gene names	FAM13A1, KIAA0914
Domain Architecture	No domain graphic available
Description	Protein FAM13A1.

FA13A_MOUSE
θ value	θ > 10 (rank : 234)	NC score	0.053795 (rank : 235)
Query Neighborhood Hits	190	Target Neighborhood Hits	83	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BGI4, Q8BZ91	Gene names	Fam13a1, Precm1
Domain Architecture	No domain graphic available
Description	Protein FAM13A1 (Precm1 protein).

GRAP2_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.096765 (rank : 92)
Query Neighborhood Hits	190	Target Neighborhood Hits	304	Shared Neighborhood Hits	57
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 236)	NC score	0.093657 (rank : 100)
Query Neighborhood Hits	190	Target Neighborhood Hits	297	Shared Neighborhood Hits	56
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.117907 (rank : 71)
Query Neighborhood Hits	190	Target Neighborhood Hits	307	Shared Neighborhood Hits	59
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 238)	NC score	0.114905 (rank : 73)
Query Neighborhood Hits	190	Target Neighborhood Hits	309	Shared Neighborhood Hits	59
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.112928 (rank : 75)
Query Neighborhood Hits	190	Target Neighborhood Hits	310	Shared Neighborhood Hits	60
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 240)	NC score	0.112706 (rank : 76)
Query Neighborhood Hits	190	Target Neighborhood Hits	312	Shared Neighborhood Hits	60
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRP3_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.080079 (rank : 132)
Query Neighborhood Hits	190	Target Neighborhood Hits	131	Shared Neighborhood Hits	10
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

HAPIP_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.050466 (rank : 263)
Query Neighborhood Hits	190	Target Neighborhood Hits	350	Shared Neighborhood Hits	18
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

HCLS1_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.074861 (rank : 144)
Query Neighborhood Hits	190	Target Neighborhood Hits	358	Shared Neighborhood Hits	43
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 244)	NC score	0.073714 (rank : 150)
Query Neighborhood Hits	190	Target Neighborhood Hits	329	Shared Neighborhood Hits	42
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HECD2_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.055884 (rank : 223)
Query Neighborhood Hits	190	Target Neighborhood Hits	41	Shared Neighborhood Hits	11
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.056285 (rank : 218)
Query Neighborhood Hits	190	Target Neighborhood Hits	38	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HUWE1_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.059789 (rank : 191)
Query Neighborhood Hits	190	Target Neighborhood Hits	443	Shared Neighborhood Hits	17
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.059880 (rank : 189)
Query Neighborhood Hits	190	Target Neighborhood Hits	406	Shared Neighborhood Hits	18
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

ITSN2_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.075162 (rank : 143)
Query Neighborhood Hits	190	Target Neighborhood Hits	1173	Shared Neighborhood Hits	79
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	θ > 10 (rank : 250)	NC score	0.073905 (rank : 149)
Query Neighborhood Hits	190	Target Neighborhood Hits	1371	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

K0317_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.058259 (rank : 204)
Query Neighborhood Hits	190	Target Neighborhood Hits	46	Shared Neighborhood Hits	11
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.058196 (rank : 205)
Query Neighborhood Hits	190	Target Neighborhood Hits	43	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

MYO1E_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.052163 (rank : 251)
Query Neighborhood Hits	190	Target Neighborhood Hits	293	Shared Neighborhood Hits	49
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

MYO1F_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.054430 (rank : 231)
Query Neighborhood Hits	190	Target Neighborhood Hits	275	Shared Neighborhood Hits	49
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
θ value	θ > 10 (rank : 255)	NC score	0.054338 (rank : 232)
Query Neighborhood Hits	190	Target Neighborhood Hits	262	Shared Neighborhood Hits	49
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

NCF1_MOUSE
θ value	θ > 10 (rank : 256)	NC score	0.053377 (rank : 238)
Query Neighborhood Hits	190	Target Neighborhood Hits	198	Shared Neighborhood Hits	42
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.073218 (rank : 153)
Query Neighborhood Hits	190	Target Neighborhood Hits	229	Shared Neighborhood Hits	46
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.060552 (rank : 184)
Query Neighborhood Hits	190	Target Neighborhood Hits	161	Shared Neighborhood Hits	26
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 259)	NC score	0.071973 (rank : 157)
Query Neighborhood Hits	190	Target Neighborhood Hits	177	Shared Neighborhood Hits	35
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.104341 (rank : 86)
Query Neighborhood Hits	190	Target Neighborhood Hits	312	Shared Neighborhood Hits	49
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NPHP1_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.076479 (rank : 140)
Query Neighborhood Hits	190	Target Neighborhood Hits	288	Shared Neighborhood Hits	49
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.084748 (rank : 118)
Query Neighborhood Hits	190	Target Neighborhood Hits	267	Shared Neighborhood Hits	49
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OCRL_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.300652 (rank : 62)
Query Neighborhood Hits	190	Target Neighborhood Hits	77	Shared Neighborhood Hits	50
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).

OSTF1_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.065442 (rank : 170)
Query Neighborhood Hits	190	Target Neighborhood Hits	466	Shared Neighborhood Hits	50
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.060876 (rank : 182)
Query Neighborhood Hits	190	Target Neighborhood Hits	467	Shared Neighborhood Hits	50
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

P55G_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.089458 (rank : 104)
Query Neighborhood Hits	190	Target Neighborhood Hits	451	Shared Neighborhood Hits	41
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.087881 (rank : 109)
Query Neighborhood Hits	190	Target Neighborhood Hits	401	Shared Neighborhood Hits	41
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

PACN1_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.055107 (rank : 228)
Query Neighborhood Hits	190	Target Neighborhood Hits	320	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.055258 (rank : 225)
Query Neighborhood Hits	190	Target Neighborhood Hits	283	Shared Neighborhood Hits	49
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.056722 (rank : 214)
Query Neighborhood Hits	190	Target Neighborhood Hits	339	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.052963 (rank : 242)
Query Neighborhood Hits	190	Target Neighborhood Hits	382	Shared Neighborhood Hits	49
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PCTL_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.061212 (rank : 179)
Query Neighborhood Hits	190	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y365, O60532	Gene names	STARD10, SDCCAG28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28) (Antigen NY-CO-28).

PCTL_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.061935 (rank : 178)
Query Neighborhood Hits	190	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JMD3	Gene names	Stard10, Pctpl, Sdccag28, Sdccagg28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28 homolog).

PDZD8_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.056487 (rank : 217)
Query Neighborhood Hits	190	Target Neighborhood Hits	185	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PIN1_HUMAN
θ value	θ > 10 (rank : 275)	NC score	0.053177 (rank : 241)
Query Neighborhood Hits	190	Target Neighborhood Hits	59	Shared Neighborhood Hits	26
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PIN1_MOUSE
θ value	θ > 10 (rank : 276)	NC score	0.060709 (rank : 183)
Query Neighborhood Hits	190	Target Neighborhood Hits	60	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PINL_HUMAN
θ value	θ > 10 (rank : 277)	NC score	0.058835 (rank : 198)
Query Neighborhood Hits	190	Target Neighborhood Hits	47	Shared Neighborhood Hits	24
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

PKHA1_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.071787 (rank : 158)
Query Neighborhood Hits	190	Target Neighborhood Hits	127	Shared Neighborhood Hits	19
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.056233 (rank : 221)
Query Neighborhood Hits	190	Target Neighborhood Hits	120	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA5_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.059606 (rank : 193)
Query Neighborhood Hits	190	Target Neighborhood Hits	455	Shared Neighborhood Hits	52
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PLCG1_HUMAN
θ value	θ > 10 (rank : 281)	NC score	0.059497 (rank : 194)
Query Neighborhood Hits	190	Target Neighborhood Hits	293	Shared Neighborhood Hits	57
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 282)	NC score	0.059996 (rank : 188)
Query Neighborhood Hits	190	Target Neighborhood Hits	314	Shared Neighborhood Hits	58
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 283)	NC score	0.058444 (rank : 202)
Query Neighborhood Hits	190	Target Neighborhood Hits	280	Shared Neighborhood Hits	48
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PLEK_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.053773 (rank : 236)
Query Neighborhood Hits	190	Target Neighborhood Hits	110	Shared Neighborhood Hits	15
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PPIP1_HUMAN
θ value	θ > 10 (rank : 285)	NC score	0.073704 (rank : 151)
Query Neighborhood Hits	190	Target Neighborhood Hits	389	Shared Neighborhood Hits	57
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 286)	NC score	0.067777 (rank : 167)
Query Neighborhood Hits	190	Target Neighborhood Hits	377	Shared Neighborhood Hits	51
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

RASA1_HUMAN
θ value	θ > 10 (rank : 287)	NC score	0.066820 (rank : 168)
Query Neighborhood Hits	190	Target Neighborhood Hits	258	Shared Neighborhood Hits	39
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

SAV1_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.058580 (rank : 200)
Query Neighborhood Hits	190	Target Neighborhood Hits	51	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.058126 (rank : 207)
Query Neighborhood Hits	190	Target Neighborhood Hits	48	Shared Neighborhood Hits	20
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

SH21A_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.065110 (rank : 172)
Query Neighborhood Hits	190	Target Neighborhood Hits	89	Shared Neighborhood Hits	24
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.064853 (rank : 173)
Query Neighborhood Hits	190	Target Neighborhood Hits	89	Shared Neighborhood Hits	24
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_MOUSE
θ value	θ > 10 (rank : 292)	NC score	0.056181 (rank : 222)
Query Neighborhood Hits	190	Target Neighborhood Hits	101	Shared Neighborhood Hits	26
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH3G1_HUMAN
θ value	θ > 10 (rank : 293)	NC score	0.052466 (rank : 248)
Query Neighborhood Hits	190	Target Neighborhood Hits	307	Shared Neighborhood Hits	47
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G2_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.056255 (rank : 219)
Query Neighborhood Hits	190	Target Neighborhood Hits	324	Shared Neighborhood Hits	52
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 295)	NC score	0.056500 (rank : 216)
Query Neighborhood Hits	190	Target Neighborhood Hits	319	Shared Neighborhood Hits	49
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3K1_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.072182 (rank : 154)
Query Neighborhood Hits	190	Target Neighborhood Hits	341	Shared Neighborhood Hits	51
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.076504 (rank : 139)
Query Neighborhood Hits	190	Target Neighborhood Hits	332	Shared Neighborhood Hits	52
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SLAP1_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.084105 (rank : 124)
Query Neighborhood Hits	190	Target Neighborhood Hits	113	Shared Neighborhood Hits	32
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 299)	NC score	0.086999 (rank : 111)
Query Neighborhood Hits	190	Target Neighborhood Hits	117	Shared Neighborhood Hits	32
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.079229 (rank : 135)
Query Neighborhood Hits	190	Target Neighborhood Hits	139	Shared Neighborhood Hits	37
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SMUF1_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.071987 (rank : 155)
Query Neighborhood Hits	190	Target Neighborhood Hits	135	Shared Neighborhood Hits	23
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
θ value	θ > 10 (rank : 302)	NC score	0.071978 (rank : 156)
Query Neighborhood Hits	190	Target Neighborhood Hits	142	Shared Neighborhood Hits	24
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SPN90_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.068431 (rank : 165)
Query Neighborhood Hits	190	Target Neighborhood Hits	157	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 304)	NC score	0.059384 (rank : 196)
Query Neighborhood Hits	190	Target Neighborhood Hits	157	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SPTB1_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.069134 (rank : 161)
Query Neighborhood Hits	190	Target Neighborhood Hits	541	Shared Neighborhood Hits	16
SwissProt Accessions	P11277, Q15510, Q15519	Gene names	SPTB, SPTB1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

SPTB1_MOUSE
θ value	θ > 10 (rank : 306)	NC score	0.067850 (rank : 166)
Query Neighborhood Hits	190	Target Neighborhood Hits	543	Shared Neighborhood Hits	14
SwissProt Accessions	P15508	Gene names	Sptb, Spnb-1, Spnb1, Sptb1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

SRC8_HUMAN
θ value	θ > 10 (rank : 307)	NC score	0.058659 (rank : 199)
Query Neighborhood Hits	190	Target Neighborhood Hits	269	Shared Neighborhood Hits	43
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 308)	NC score	0.059645 (rank : 192)
Query Neighborhood Hits	190	Target Neighborhood Hits	292	Shared Neighborhood Hits	43
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

STAC3_HUMAN
θ value	θ > 10 (rank : 309)	NC score	0.088769 (rank : 107)
Query Neighborhood Hits	190	Target Neighborhood Hits	228	Shared Neighborhood Hits	48
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 310)	NC score	0.090023 (rank : 103)
Query Neighborhood Hits	190	Target Neighborhood Hits	232	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 311)	NC score	0.080829 (rank : 130)
Query Neighborhood Hits	190	Target Neighborhood Hits	276	Shared Neighborhood Hits	51
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 312)	NC score	0.086180 (rank : 115)
Query Neighborhood Hits	190	Target Neighborhood Hits	268	Shared Neighborhood Hits	49
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 313)	NC score	0.057386 (rank : 212)
Query Neighborhood Hits	190	Target Neighborhood Hits	271	Shared Neighborhood Hits	51
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 314)	NC score	0.058071 (rank : 208)
Query Neighborhood Hits	190	Target Neighborhood Hits	273	Shared Neighborhood Hits	49
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.059410 (rank : 195)
Query Neighborhood Hits	190	Target Neighborhood Hits	288	Shared Neighborhood Hits	51
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 316)	NC score	0.062075 (rank : 177)
Query Neighborhood Hits	190	Target Neighborhood Hits	285	Shared Neighborhood Hits	54
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

TRIPC_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.051563 (rank : 257)
Query Neighborhood Hits	190	Target Neighborhood Hits	319	Shared Neighborhood Hits	19
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

UBE3A_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.054036 (rank : 233)
Query Neighborhood Hits	190	Target Neighborhood Hits	49	Shared Neighborhood Hits	11
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3A_MOUSE
θ value	θ > 10 (rank : 319)	NC score	0.053503 (rank : 237)
Query Neighborhood Hits	190	Target Neighborhood Hits	47	Shared Neighborhood Hits	12
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

UBE3C_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.052904 (rank : 243)
Query Neighborhood Hits	190	Target Neighborhood Hits	51	Shared Neighborhood Hits	11
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
θ value	θ > 10 (rank : 321)	NC score	0.052683 (rank : 245)
Query Neighborhood Hits	190	Target Neighborhood Hits	48	Shared Neighborhood Hits	11
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UN13A_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.055579 (rank : 224)
Query Neighborhood Hits	190	Target Neighborhood Hits	285	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.056978 (rank : 213)
Query Neighborhood Hits	190	Target Neighborhood Hits	217	Shared Neighborhood Hits	21
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_MOUSE
θ value	θ > 10 (rank : 324)	NC score	0.053203 (rank : 240)
Query Neighborhood Hits	190	Target Neighborhood Hits	210	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

VAV2_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.084434 (rank : 119)
Query Neighborhood Hits	190	Target Neighborhood Hits	453	Shared Neighborhood Hits	59
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	θ > 10 (rank : 326)	NC score	0.084014 (rank : 125)
Query Neighborhood Hits	190	Target Neighborhood Hits	456	Shared Neighborhood Hits	59
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	θ > 10 (rank : 327)	NC score	0.096603 (rank : 93)
Query Neighborhood Hits	190	Target Neighborhood Hits	398	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 328)	NC score	0.095239 (rank : 97)
Query Neighborhood Hits	190	Target Neighborhood Hits	404	Shared Neighborhood Hits	55
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
θ value	θ > 10 (rank : 329)	NC score	0.075464 (rank : 141)
Query Neighborhood Hits	190	Target Neighborhood Hits	452	Shared Neighborhood Hits	57
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 330)	NC score	0.078411 (rank : 136)
Query Neighborhood Hits	190	Target Neighborhood Hits	430	Shared Neighborhood Hits	61
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

WWC1_HUMAN
θ value	θ > 10 (rank : 331)	NC score	0.051197 (rank : 260)
Query Neighborhood Hits	190	Target Neighborhood Hits	290	Shared Neighborhood Hits	30
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWTR1_MOUSE
θ value	θ > 10 (rank : 332)	NC score	0.057968 (rank : 210)
Query Neighborhood Hits	190	Target Neighborhood Hits	54	Shared Neighborhood Hits	20
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

Hits sorted by NC score

RHG12_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	190	Target Neighborhood Hits	190	Shared Neighborhood Hits	190
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
NC score	0.992007 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	190	Target Neighborhood Hits	204	Shared Neighborhood Hits	152
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG09_HUMAN
NC score	0.933039 (rank : 3)	θ value	1.65806e-78 (rank : 3)
Query Neighborhood Hits	190	Target Neighborhood Hits	186	Shared Neighborhood Hits	102
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

GRLF1_HUMAN
NC score	0.799195 (rank : 4)	θ value	3.87602e-27 (rank : 9)
Query Neighborhood Hits	190	Target Neighborhood Hits	167	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

GMIP_MOUSE
NC score	0.798332 (rank : 5)	θ value	1.47631e-18 (rank : 23)
Query Neighborhood Hits	190	Target Neighborhood Hits	202	Shared Neighborhood Hits	71
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

3BP1_MOUSE
NC score	0.794182 (rank : 6)	θ value	2.35696e-16 (rank : 35)
Query Neighborhood Hits	190	Target Neighborhood Hits	238	Shared Neighborhood Hits	62
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

GMIP_HUMAN
NC score	0.790994 (rank : 7)	θ value	7.32683e-18 (rank : 29)
Query Neighborhood Hits	190	Target Neighborhood Hits	225	Shared Neighborhood Hits	68
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

RGAP1_HUMAN
NC score	0.789096 (rank : 8)	θ value	8.10077e-17 (rank : 32)
Query Neighborhood Hits	190	Target Neighborhood Hits	189	Shared Neighborhood Hits	64
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RHG06_HUMAN
NC score	0.785582 (rank : 9)	θ value	5.60996e-18 (rank : 27)
Query Neighborhood Hits	190	Target Neighborhood Hits	114	Shared Neighborhood Hits	61
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RGAP1_MOUSE
NC score	0.785558 (rank : 10)	θ value	1.80466e-16 (rank : 33)
Query Neighborhood Hits	190	Target Neighborhood Hits	185	Shared Neighborhood Hits	64
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

CHIO_MOUSE
NC score	0.785486 (rank : 11)	θ value	1.4233e-29 (rank : 5)
Query Neighborhood Hits	190	Target Neighborhood Hits	130	Shared Neighborhood Hits	61
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

RHG06_MOUSE
NC score	0.783382 (rank : 12)	θ value	2.13179e-17 (rank : 30)
Query Neighborhood Hits	190	Target Neighborhood Hits	105	Shared Neighborhood Hits	64
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

3BP1_HUMAN
NC score	0.781147 (rank : 13)	θ value	7.0802e-21 (rank : 16)
Query Neighborhood Hits	190	Target Neighborhood Hits	376	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

TCGAP_MOUSE
NC score	0.780060 (rank : 14)	θ value	5.06226e-27 (rank : 11)
Query Neighborhood Hits	190	Target Neighborhood Hits	409	Shared Neighborhood Hits	79
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

OPHN1_MOUSE
NC score	0.779594 (rank : 15)	θ value	2.77775e-25 (rank : 13)
Query Neighborhood Hits	190	Target Neighborhood Hits	174	Shared Neighborhood Hits	65
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

OPHN1_HUMAN
NC score	0.779425 (rank : 16)	θ value	8.08199e-25 (rank : 14)
Query Neighborhood Hits	190	Target Neighborhood Hits	161	Shared Neighborhood Hits	61
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

RHG18_HUMAN
NC score	0.771914 (rank : 17)	θ value	1.80466e-16 (rank : 34)
Query Neighborhood Hits	190	Target Neighborhood Hits	90	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

RHG01_HUMAN
NC score	0.771394 (rank : 18)	θ value	1.13037e-18 (rank : 22)
Query Neighborhood Hits	190	Target Neighborhood Hits	75	Shared Neighborhood Hits	61
SwissProt Accessions	Q07960	Gene names	ARHGAP1, CDC42GAP, RHOGAP1
Domain Architecture
Description	Rho-GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (CDC42 GTPase-activating protein) (p50-RhoGAP).

RHG05_MOUSE
NC score	0.766197 (rank : 19)	θ value	7.0802e-21 (rank : 18)
Query Neighborhood Hits	190	Target Neighborhood Hits	165	Shared Neighborhood Hits	69
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG18_MOUSE
NC score	0.763882 (rank : 20)	θ value	4.44505e-15 (rank : 38)
Query Neighborhood Hits	190	Target Neighborhood Hits	110	Shared Neighborhood Hits	63
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

CHIN_MOUSE
NC score	0.760056 (rank : 21)	θ value	3.17079e-29 (rank : 6)
Query Neighborhood Hits	190	Target Neighborhood Hits	229	Shared Neighborhood Hits	75
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
NC score	0.757820 (rank : 22)	θ value	1.4233e-29 (rank : 4)
Query Neighborhood Hits	190	Target Neighborhood Hits	220	Shared Neighborhood Hits	73
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

RHG05_HUMAN
NC score	0.756801 (rank : 23)	θ value	2.97466e-19 (rank : 20)
Query Neighborhood Hits	190	Target Neighborhood Hits	158	Shared Neighborhood Hits	67
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

CHIN_HUMAN
NC score	0.756565 (rank : 24)	θ value	4.14116e-29 (rank : 7)
Query Neighborhood Hits	190	Target Neighborhood Hits	227	Shared Neighborhood Hits	73
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

RHG08_HUMAN
NC score	0.752006 (rank : 25)	θ value	3.63628e-17 (rank : 31)
Query Neighborhood Hits	190	Target Neighborhood Hits	88	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NSG0, O75983, O95695, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NVX8, Q9NXL1, Q9UH20	Gene names	ARHGAP8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

RHG08_MOUSE
NC score	0.750468 (rank : 26)	θ value	1.29331e-14 (rank : 42)
Query Neighborhood Hits	190	Target Neighborhood Hits	73	Shared Neighborhood Hits	61
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

ABR_HUMAN
NC score	0.745987 (rank : 27)	θ value	3.87602e-27 (rank : 8)
Query Neighborhood Hits	190	Target Neighborhood Hits	166	Shared Neighborhood Hits	67
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

RHG26_HUMAN
NC score	0.743431 (rank : 28)	θ value	1.5242e-23 (rank : 15)
Query Neighborhood Hits	190	Target Neighborhood Hits	281	Shared Neighborhood Hits	83
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RHG04_HUMAN
NC score	0.734895 (rank : 29)	θ value	5.60996e-18 (rank : 26)
Query Neighborhood Hits	190	Target Neighborhood Hits	307	Shared Neighborhood Hits	100
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

BCR_HUMAN
NC score	0.726408 (rank : 30)	θ value	1.12775e-26 (rank : 12)
Query Neighborhood Hits	190	Target Neighborhood Hits	204	Shared Neighborhood Hits	65
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

SRGP2_HUMAN
NC score	0.723893 (rank : 31)	θ value	5.07402e-19 (rank : 21)
Query Neighborhood Hits	190	Target Neighborhood Hits	331	Shared Neighborhood Hits	100
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
NC score	0.716229 (rank : 32)	θ value	4.29542e-18 (rank : 25)
Query Neighborhood Hits	190	Target Neighborhood Hits	324	Shared Neighborhood Hits	100
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRGP1_HUMAN
NC score	0.710152 (rank : 33)	θ value	5.60996e-18 (rank : 28)
Query Neighborhood Hits	190	Target Neighborhood Hits	390	Shared Neighborhood Hits	101
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

RBP1_MOUSE
NC score	0.709410 (rank : 34)	θ value	6.85773e-16 (rank : 36)
Query Neighborhood Hits	190	Target Neighborhood Hits	493	Shared Neighborhood Hits	70
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

FNBP2_HUMAN
NC score	0.707200 (rank : 35)	θ value	1.92812e-18 (rank : 24)
Query Neighborhood Hits	190	Target Neighborhood Hits	432	Shared Neighborhood Hits	102
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

RHG25_MOUSE
NC score	0.706606 (rank : 36)	θ value	4.44505e-15 (rank : 39)
Query Neighborhood Hits	190	Target Neighborhood Hits	492	Shared Neighborhood Hits	75
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RBP1_HUMAN
NC score	0.692559 (rank : 37)	θ value	1.99529e-15 (rank : 37)
Query Neighborhood Hits	190	Target Neighborhood Hits	521	Shared Neighborhood Hits	73
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

TCGAP_HUMAN
NC score	0.692146 (rank : 38)	θ value	5.06226e-27 (rank : 10)
Query Neighborhood Hits	190	Target Neighborhood Hits	872	Shared Neighborhood Hits	83
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TAGAP_HUMAN
NC score	0.690912 (rank : 39)	θ value	1.33837e-11 (rank : 49)
Query Neighborhood Hits	190	Target Neighborhood Hits	82	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

TAGAP_MOUSE
NC score	0.688320 (rank : 40)	θ value	9.59137e-10 (rank : 53)
Query Neighborhood Hits	190	Target Neighborhood Hits	83	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

RHG25_HUMAN
NC score	0.681181 (rank : 41)	θ value	8.38298e-14 (rank : 44)
Query Neighborhood Hits	190	Target Neighborhood Hits	550	Shared Neighborhood Hits	74
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG07_MOUSE
NC score	0.677718 (rank : 42)	θ value	1.29331e-14 (rank : 41)
Query Neighborhood Hits	190	Target Neighborhood Hits	103	Shared Neighborhood Hits	61
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

RHG07_HUMAN
NC score	0.673809 (rank : 43)	θ value	9.90251e-15 (rank : 40)
Query Neighborhood Hits	190	Target Neighborhood Hits	108	Shared Neighborhood Hits	61
SwissProt Accessions	Q96QB1, O14868, O43199, Q9C0E0	Gene names	DLC1, ARHGAP7, KIAA1723, STARD12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

STA13_HUMAN
NC score	0.631003 (rank : 44)	θ value	3.52202e-12 (rank : 48)
Query Neighborhood Hits	190	Target Neighborhood Hits	89	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

STAR8_MOUSE
NC score	0.627124 (rank : 45)	θ value	1.63604e-09 (rank : 55)
Query Neighborhood Hits	190	Target Neighborhood Hits	101	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STA13_MOUSE
NC score	0.623281 (rank : 46)	θ value	1.2105e-12 (rank : 47)
Query Neighborhood Hits	190	Target Neighborhood Hits	89	Shared Neighborhood Hits	58
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

CEND2_HUMAN
NC score	0.620711 (rank : 47)	θ value	3.76295e-14 (rank : 43)
Query Neighborhood Hits	190	Target Neighborhood Hits	166	Shared Neighborhood Hits	65
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

STAR8_HUMAN
NC score	0.618585 (rank : 48)	θ value	2.13673e-09 (rank : 56)
Query Neighborhood Hits	190	Target Neighborhood Hits	216	Shared Neighborhood Hits	62
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

CE005_HUMAN
NC score	0.611162 (rank : 49)	θ value	9.59137e-10 (rank : 52)
Query Neighborhood Hits	190	Target Neighborhood Hits	213	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

CE005_MOUSE
NC score	0.607911 (rank : 50)	θ value	1.63604e-09 (rank : 54)
Query Neighborhood Hits	190	Target Neighborhood Hits	238	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

CEND3_MOUSE
NC score	0.587450 (rank : 51)	θ value	2.43908e-13 (rank : 45)
Query Neighborhood Hits	190	Target Neighborhood Hits	228	Shared Neighborhood Hits	62
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CEND3_HUMAN
NC score	0.577671 (rank : 52)	θ value	4.16044e-13 (rank : 46)
Query Neighborhood Hits	190	Target Neighborhood Hits	275	Shared Neighborhood Hits	63
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

K1688_MOUSE
NC score	0.537178 (rank : 53)	θ value	3.77169e-06 (rank : 62)
Query Neighborhood Hits	190	Target Neighborhood Hits	188	Shared Neighborhood Hits	66
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

CEND1_MOUSE
NC score	0.530899 (rank : 54)	θ value	2.98157e-11 (rank : 50)
Query Neighborhood Hits	190	Target Neighborhood Hits	260	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

K1688_HUMAN
NC score	0.527560 (rank : 55)	θ value	4.92598e-06 (rank : 63)
Query Neighborhood Hits	190	Target Neighborhood Hits	217	Shared Neighborhood Hits	69
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

CEND1_HUMAN
NC score	0.508949 (rank : 56)	θ value	4.30538e-10 (rank : 51)
Query Neighborhood Hits	190	Target Neighborhood Hits	284	Shared Neighborhood Hits	62
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

P85A_HUMAN
NC score	0.420703 (rank : 57)	θ value	6.87365e-08 (rank : 58)
Query Neighborhood Hits	190	Target Neighborhood Hits	479	Shared Neighborhood Hits	95
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

MYO9B_MOUSE
NC score	0.419175 (rank : 58)	θ value	1.2077e-20 (rank : 19)
Query Neighborhood Hits	190	Target Neighborhood Hits	311	Shared Neighborhood Hits	65
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

P85A_MOUSE
NC score	0.414974 (rank : 59)	θ value	6.87365e-08 (rank : 59)
Query Neighborhood Hits	190	Target Neighborhood Hits	435	Shared Neighborhood Hits	96
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

MYO9B_HUMAN
NC score	0.412996 (rank : 60)	θ value	7.0802e-21 (rank : 17)
Query Neighborhood Hits	190	Target Neighborhood Hits	641	Shared Neighborhood Hits	68
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

I5P2_HUMAN
NC score	0.329635 (rank : 61)	θ value	4.1701e-05 (rank : 64)
Query Neighborhood Hits	190	Target Neighborhood Hits	86	Shared Neighborhood Hits	51
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

OCRL_HUMAN
NC score	0.300652 (rank : 62)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	190	Target Neighborhood Hits	77	Shared Neighborhood Hits	50
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).

PRP40_HUMAN
NC score	0.145486 (rank : 63)	θ value	0.00035302 (rank : 69)
Query Neighborhood Hits	190	Target Neighborhood Hits	442	Shared Neighborhood Hits	40
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

P85B_HUMAN
NC score	0.145149 (rank : 64)	θ value	0.62314 (rank : 122)
Query Neighborhood Hits	190	Target Neighborhood Hits	543	Shared Neighborhood Hits	59
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PRP40_MOUSE
NC score	0.142677 (rank : 65)	θ value	0.000461057 (rank : 70)
Query Neighborhood Hits	190	Target Neighborhood Hits	447	Shared Neighborhood Hits	38
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

NCK2_HUMAN
NC score	0.126380 (rank : 66)	θ value	3.0926 (rank : 148)
Query Neighborhood Hits	190	Target Neighborhood Hits	310	Shared Neighborhood Hits	53
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

CRKL_HUMAN
NC score	0.125119 (rank : 67)	θ value	0.00390308 (rank : 79)
Query Neighborhood Hits	190	Target Neighborhood Hits	313	Shared Neighborhood Hits	59
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

SPTA1_MOUSE
NC score	0.120945 (rank : 68)	θ value	0.0113563 (rank : 84)
Query Neighborhood Hits	190	Target Neighborhood Hits	675	Shared Neighborhood Hits	66
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

CRKL_MOUSE
NC score	0.120067 (rank : 69)	θ value	0.00869519 (rank : 82)
Query Neighborhood Hits	190	Target Neighborhood Hits	307	Shared Neighborhood Hits	60
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

SPTA2_HUMAN
NC score	0.118591 (rank : 70)	θ value	5.44631e-05 (rank : 65)
Query Neighborhood Hits	190	Target Neighborhood Hits	888	Shared Neighborhood Hits	56
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

GRAP_HUMAN
NC score	0.117907 (rank : 71)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	190	Target Neighborhood Hits	307	Shared Neighborhood Hits	59
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

YAP1_MOUSE
NC score	0.115527 (rank : 72)	θ value	0.0148317 (rank : 87)
Query Neighborhood Hits	190	Target Neighborhood Hits	96	Shared Neighborhood Hits	28
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

GRAP_MOUSE
NC score	0.114905 (rank : 73)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	190	Target Neighborhood Hits	309	Shared Neighborhood Hits	59
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

ITCH_MOUSE
NC score	0.113142 (rank : 74)	θ value	0.000158464 (rank : 67)
Query Neighborhood Hits	190	Target Neighborhood Hits	127	Shared Neighborhood Hits	32
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

GRB2_HUMAN
NC score	0.112928 (rank : 75)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	190	Target Neighborhood Hits	310	Shared Neighborhood Hits	60
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.112706 (rank : 76)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	190	Target Neighborhood Hits	312	Shared Neighborhood Hits	60
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

P85B_MOUSE
NC score	0.112223 (rank : 77)	θ value	5.27518 (rank : 167)
Query Neighborhood Hits	190	Target Neighborhood Hits	519	Shared Neighborhood Hits	57
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

ITCH_HUMAN
NC score	0.111773 (rank : 78)	θ value	7.1131e-05 (rank : 66)
Query Neighborhood Hits	190	Target Neighborhood Hits	162	Shared Neighborhood Hits	31
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

SPTA1_HUMAN
NC score	0.111348 (rank : 79)	θ value	0.0736092 (rank : 99)
Query Neighborhood Hits	190	Target Neighborhood Hits	748	Shared Neighborhood Hits	58
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

WWP1_MOUSE
NC score	0.111169 (rank : 80)	θ value	0.000602161 (rank : 71)
Query Neighborhood Hits	190	Target Neighborhood Hits	138	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP2_MOUSE
NC score	0.110192 (rank : 81)	θ value	0.00102713 (rank : 75)
Query Neighborhood Hits	190	Target Neighborhood Hits	118	Shared Neighborhood Hits	30
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

WWP2_HUMAN
NC score	0.109883 (rank : 82)	θ value	0.00102713 (rank : 74)
Query Neighborhood Hits	190	Target Neighborhood Hits	177	Shared Neighborhood Hits	29
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP1_HUMAN
NC score	0.109047 (rank : 83)	θ value	0.0148317 (rank : 86)
Query Neighborhood Hits	190	Target Neighborhood Hits	262	Shared Neighborhood Hits	30
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

SPTN4_HUMAN
NC score	0.106606 (rank : 84)	θ value	6.87365e-08 (rank : 60)
Query Neighborhood Hits	190	Target Neighborhood Hits	570	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

VINEX_MOUSE
NC score	0.106421 (rank : 85)	θ value	0.813845 (rank : 125)
Query Neighborhood Hits	190	Target Neighborhood Hits	286	Shared Neighborhood Hits	52
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

NCK1_HUMAN
NC score	0.104341 (rank : 86)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	190	Target Neighborhood Hits	312	Shared Neighborhood Hits	49
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

GAS7_MOUSE
NC score	0.103537 (rank : 87)	θ value	0.365318 (rank : 114)
Query Neighborhood Hits	190	Target Neighborhood Hits	259	Shared Neighborhood Hits	35
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

VINEX_HUMAN
NC score	0.101409 (rank : 88)	θ value	6.88961 (rank : 179)
Query Neighborhood Hits	190	Target Neighborhood Hits	270	Shared Neighborhood Hits	53
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

GAS7_HUMAN
NC score	0.099598 (rank : 89)	θ value	0.163984 (rank : 105)
Query Neighborhood Hits	190	Target Neighborhood Hits	258	Shared Neighborhood Hits	36
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

SPTB2_HUMAN
NC score	0.097810 (rank : 90)	θ value	4.76016e-09 (rank : 57)
Query Neighborhood Hits	190	Target Neighborhood Hits	748	Shared Neighborhood Hits	25
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTN2_HUMAN
NC score	0.097478 (rank : 91)	θ value	0.00298849 (rank : 77)
Query Neighborhood Hits	190	Target Neighborhood Hits	535	Shared Neighborhood Hits	23
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

GRAP2_HUMAN
NC score	0.096765 (rank : 92)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	190	Target Neighborhood Hits	304	Shared Neighborhood Hits	57
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

VAV3_HUMAN
NC score	0.096603 (rank : 93)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	190	Target Neighborhood Hits	398	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

SRBS1_HUMAN
NC score	0.096360 (rank : 94)	θ value	8.99809 (rank : 189)
Query Neighborhood Hits	190	Target Neighborhood Hits	396	Shared Neighborhood Hits	60
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SPTB2_MOUSE
NC score	0.095985 (rank : 95)	θ value	8.97725e-08 (rank : 61)
Query Neighborhood Hits	190	Target Neighborhood Hits	770	Shared Neighborhood Hits	26
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

TCRG1_HUMAN
NC score	0.095495 (rank : 96)	θ value	0.0252991 (rank : 91)
Query Neighborhood Hits	190	Target Neighborhood Hits	929	Shared Neighborhood Hits	43
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

VAV3_MOUSE
NC score	0.095239 (rank : 97)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	190	Target Neighborhood Hits	404	Shared Neighborhood Hits	55
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

TCRG1_MOUSE
NC score	0.095009 (rank : 98)	θ value	0.0330416 (rank : 96)
Query Neighborhood Hits	190	Target Neighborhood Hits	947	Shared Neighborhood Hits	44
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

YAP1_HUMAN
NC score	0.094919 (rank : 99)	θ value	0.21417 (rank : 108)
Query Neighborhood Hits	190	Target Neighborhood Hits	173	Shared Neighborhood Hits	29
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

GRAP2_MOUSE
NC score	0.093657 (rank : 100)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	190	Target Neighborhood Hits	297	Shared Neighborhood Hits	56
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

SMUF2_HUMAN
NC score	0.092715 (rank : 101)	θ value	0.0736092 (rank : 98)
Query Neighborhood Hits	190	Target Neighborhood Hits	142	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SRBS1_MOUSE
NC score	0.091300 (rank : 102)	θ value	6.88961 (rank : 177)
Query Neighborhood Hits	190	Target Neighborhood Hits	409	Shared Neighborhood Hits	57
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

STAC3_MOUSE
NC score	0.090023 (rank : 103)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	190	Target Neighborhood Hits	232	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

P55G_HUMAN
NC score	0.089458 (rank : 104)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	190	Target Neighborhood Hits	451	Shared Neighborhood Hits	41
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

DAPP1_MOUSE
NC score	0.089038 (rank : 105)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	190	Target Neighborhood Hits	225	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

SLAP2_MOUSE
NC score	0.088847 (rank : 106)	θ value	8.99809 (rank : 188)
Query Neighborhood Hits	190	Target Neighborhood Hits	136	Shared Neighborhood Hits	37
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

STAC3_HUMAN
NC score	0.088769 (rank : 107)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	190	Target Neighborhood Hits	228	Shared Neighborhood Hits	48
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

NEDD4_HUMAN
NC score	0.088402 (rank : 108)	θ value	2.36792 (rank : 142)
Query Neighborhood Hits	190	Target Neighborhood Hits	214	Shared Neighborhood Hits	30
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

P55G_MOUSE
NC score	0.087881 (rank : 109)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	190	Target Neighborhood Hits	401	Shared Neighborhood Hits	41
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

DAPP1_HUMAN
NC score	0.087803 (rank : 110)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	190	Target Neighborhood Hits	227	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

SLAP1_MOUSE
NC score	0.086999 (rank : 111)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	190	Target Neighborhood Hits	117	Shared Neighborhood Hits	32
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

CRK_HUMAN
NC score	0.086928 (rank : 112)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	190	Target Neighborhood Hits	308	Shared Neighborhood Hits	56
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

NED4L_HUMAN
NC score	0.086228 (rank : 113)	θ value	0.125558 (rank : 103)
Query Neighborhood Hits	190	Target Neighborhood Hits	238	Shared Neighborhood Hits	33
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

CRK_MOUSE
NC score	0.086202 (rank : 114)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	190	Target Neighborhood Hits	314	Shared Neighborhood Hits	56
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

STAC_MOUSE
NC score	0.086180 (rank : 115)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	190	Target Neighborhood Hits	268	Shared Neighborhood Hits	49
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

PLEK2_MOUSE
NC score	0.085727 (rank : 116)	θ value	0.00665767 (rank : 81)
Query Neighborhood Hits	190	Target Neighborhood Hits	96	Shared Neighborhood Hits	11
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

NED4L_MOUSE
NC score	0.085720 (rank : 117)	θ value	0.163984 (rank : 106)
Query Neighborhood Hits	190	Target Neighborhood Hits	231	Shared Neighborhood Hits	32
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NPHP1_MOUSE
NC score	0.084748 (rank : 118)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	190	Target Neighborhood Hits	267	Shared Neighborhood Hits	49
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

VAV2_HUMAN
NC score	0.084434 (rank : 119)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	190	Target Neighborhood Hits	453	Shared Neighborhood Hits	59
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

WBP4_MOUSE
NC score	0.084388 (rank : 120)	θ value	1.06291 (rank : 132)
Query Neighborhood Hits	190	Target Neighborhood Hits	100	Shared Neighborhood Hits	28
SwissProt Accessions	Q61048, Q8K1Z9, Q9CS45	Gene names	Wbp4, Fbp21, Fnbp21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

CIP4_HUMAN
NC score	0.084316 (rank : 121)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	190	Target Neighborhood Hits	374	Shared Neighborhood Hits	43
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

SETD2_HUMAN
NC score	0.084294 (rank : 122)	θ value	0.000786445 (rank : 73)
Query Neighborhood Hits	190	Target Neighborhood Hits	412	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

NEDD4_MOUSE
NC score	0.084275 (rank : 123)	θ value	0.62314 (rank : 121)
Query Neighborhood Hits	190	Target Neighborhood Hits	212	Shared Neighborhood Hits	31
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

SLAP1_HUMAN
NC score	0.084105 (rank : 124)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	190	Target Neighborhood Hits	113	Shared Neighborhood Hits	32
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

VAV2_MOUSE
NC score	0.084014 (rank : 125)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	190	Target Neighborhood Hits	456	Shared Neighborhood Hits	59
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

TIAM1_HUMAN
NC score	0.083424 (rank : 126)	θ value	0.00298849 (rank : 78)
Query Neighborhood Hits	190	Target Neighborhood Hits	225	Shared Neighborhood Hits	21
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

SPTN5_HUMAN
NC score	0.082159 (rank : 127)	θ value	0.125558 (rank : 104)
Query Neighborhood Hits	190	Target Neighborhood Hits	674	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

TIAM1_MOUSE
NC score	0.081361 (rank : 128)	θ value	0.00134147 (rank : 76)
Query Neighborhood Hits	190	Target Neighborhood Hits	205	Shared Neighborhood Hits	18
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ITSN1_MOUSE
NC score	0.081236 (rank : 129)	θ value	1.38821 (rank : 134)
Query Neighborhood Hits	190	Target Neighborhood Hits	1669	Shared Neighborhood Hits	93
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

STAC_HUMAN
NC score	0.080829 (rank : 130)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	190	Target Neighborhood Hits	276	Shared Neighborhood Hits	51
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

DNMBP_HUMAN
NC score	0.080719 (rank : 131)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	190	Target Neighborhood Hits	413	Shared Neighborhood Hits	60
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

GRP3_HUMAN
NC score	0.080079 (rank : 132)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	190	Target Neighborhood Hits	131	Shared Neighborhood Hits	10
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

ITSN1_HUMAN
NC score	0.079858 (rank : 133)	θ value	6.88961 (rank : 173)
Query Neighborhood Hits	190	Target Neighborhood Hits	1757	Shared Neighborhood Hits	95
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

CD2AP_HUMAN
NC score	0.079740 (rank : 134)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	190	Target Neighborhood Hits	315	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SLAP2_HUMAN
NC score	0.079229 (rank : 135)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	190	Target Neighborhood Hits	139	Shared Neighborhood Hits	37
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

VAV_MOUSE
NC score	0.078411 (rank : 136)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	190	Target Neighborhood Hits	430	Shared Neighborhood Hits	61
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

WWTR1_HUMAN
NC score	0.078277 (rank : 137)	θ value	1.06291 (rank : 133)
Query Neighborhood Hits	190	Target Neighborhood Hits	76	Shared Neighborhood Hits	23
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

CENB2_HUMAN
NC score	0.077855 (rank : 138)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	190	Target Neighborhood Hits	425	Shared Neighborhood Hits	18
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

SH3K1_MOUSE
NC score	0.076504 (rank : 139)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	190	Target Neighborhood Hits	332	Shared Neighborhood Hits	52
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

NPHP1_HUMAN
NC score	0.076479 (rank : 140)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	190	Target Neighborhood Hits	288	Shared Neighborhood Hits	49
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

VAV_HUMAN
NC score	0.075464 (rank : 141)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	190	Target Neighborhood Hits	452	Shared Neighborhood Hits	57
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

AHI1_HUMAN
NC score	0.075417 (rank : 142)	θ value	0.0330416 (rank : 92)
Query Neighborhood Hits	190	Target Neighborhood Hits	537	Shared Neighborhood Hits	51
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ITSN2_HUMAN
NC score	0.075162 (rank : 143)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	190	Target Neighborhood Hits	1173	Shared Neighborhood Hits	79
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

HCLS1_HUMAN
NC score	0.074861 (rank : 144)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	190	Target Neighborhood Hits	358	Shared Neighborhood Hits	43
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

CENB1_HUMAN
NC score	0.074541 (rank : 145)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	190	Target Neighborhood Hits	383	Shared Neighborhood Hits	15
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

ARHG7_MOUSE
NC score	0.074537 (rank : 146)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	190	Target Neighborhood Hits	396	Shared Neighborhood Hits	54
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

PLEK2_HUMAN
NC score	0.074351 (rank : 147)	θ value	0.0961366 (rank : 101)
Query Neighborhood Hits	190	Target Neighborhood Hits	101	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

CENB5_HUMAN
NC score	0.074090 (rank : 148)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	190	Target Neighborhood Hits	395	Shared Neighborhood Hits	14
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

ITSN2_MOUSE
NC score	0.073905 (rank : 149)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	190	Target Neighborhood Hits	1371	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

HCLS1_MOUSE
NC score	0.073714 (rank : 150)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	190	Target Neighborhood Hits	329	Shared Neighborhood Hits	42
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

PPIP1_HUMAN
NC score	0.073704 (rank : 151)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	190	Target Neighborhood Hits	389	Shared Neighborhood Hits	57
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

DNMBP_MOUSE
NC score	0.073230 (rank : 152)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	190	Target Neighborhood Hits	435	Shared Neighborhood Hits	57
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

NCF2_HUMAN
NC score	0.073218 (rank : 153)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	190	Target Neighborhood Hits	229	Shared Neighborhood Hits	46
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

SH3K1_HUMAN
NC score	0.072182 (rank : 154)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	190	Target Neighborhood Hits	341	Shared Neighborhood Hits	51
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SMUF1_HUMAN
NC score	0.071987 (rank : 155)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	190	Target Neighborhood Hits	135	Shared Neighborhood Hits	23
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
NC score	0.071978 (rank : 156)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	190	Target Neighborhood Hits	142	Shared Neighborhood Hits	24
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

NCF4_MOUSE
NC score	0.071973 (rank : 157)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	190	Target Neighborhood Hits	177	Shared Neighborhood Hits	35
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

PKHA1_HUMAN
NC score	0.071787 (rank : 158)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	190	Target Neighborhood Hits	127	Shared Neighborhood Hits	19
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

CD2AP_MOUSE
NC score	0.071535 (rank : 159)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	190	Target Neighborhood Hits	336	Shared Neighborhood Hits	52
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

ABI2_MOUSE
NC score	0.070452 (rank : 160)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	190	Target Neighborhood Hits	266	Shared Neighborhood Hits	44
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

SPTB1_HUMAN
NC score	0.069134 (rank : 161)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	190	Target Neighborhood Hits	541	Shared Neighborhood Hits	16
SwissProt Accessions	P11277, Q15510, Q15519	Gene names	SPTB, SPTB1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

ABI2_HUMAN
NC score	0.068854 (rank : 162)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	190	Target Neighborhood Hits	350	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

WBP4_HUMAN
NC score	0.068825 (rank : 163)	θ value	3.0926 (rank : 150)
Query Neighborhood Hits	190	Target Neighborhood Hits	86	Shared Neighborhood Hits	21
SwissProt Accessions	O75554	Gene names	WBP4, FBP21, FNBP21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

AHI1_MOUSE
NC score	0.068503 (rank : 164)	θ value	3.0926 (rank : 143)
Query Neighborhood Hits	190	Target Neighborhood Hits	496	Shared Neighborhood Hits	51
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

SPN90_HUMAN
NC score	0.068431 (rank : 165)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	190	Target Neighborhood Hits	157	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPTB1_MOUSE
NC score	0.067850 (rank : 166)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	190	Target Neighborhood Hits	543	Shared Neighborhood Hits	14
SwissProt Accessions	P15508	Gene names	Sptb, Spnb-1, Spnb1, Sptb1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

PPIP1_MOUSE
NC score	0.067777 (rank : 167)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	190	Target Neighborhood Hits	377	Shared Neighborhood Hits	51
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

RASA1_HUMAN
NC score	0.066820 (rank : 168)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	190	Target Neighborhood Hits	258	Shared Neighborhood Hits	39
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

DDEF2_HUMAN
NC score	0.065908 (rank : 169)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	190	Target Neighborhood Hits	599	Shared Neighborhood Hits	44
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

OSTF1_HUMAN
NC score	0.065442 (rank : 170)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	190	Target Neighborhood Hits	466	Shared Neighborhood Hits	50
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

ARHG7_HUMAN
NC score	0.065225 (rank : 171)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	190	Target Neighborhood Hits	347	Shared Neighborhood Hits	52
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

SH21A_HUMAN
NC score	0.065110 (rank : 172)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	190	Target Neighborhood Hits	89	Shared Neighborhood Hits	24
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
NC score	0.064853 (rank : 173)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	190	Target Neighborhood Hits	89	Shared Neighborhood Hits	24
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

PSD3_HUMAN
NC score	0.064733 (rank : 174)	θ value	0.0961366 (rank : 102)
Query Neighborhood Hits	190	Target Neighborhood Hits	75	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

ANM2_MOUSE
NC score	0.064685 (rank : 175)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	190	Target Neighborhood Hits	175	Shared Neighborhood Hits	41
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_HUMAN
NC score	0.063992 (rank : 176)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	190	Target Neighborhood Hits	175	Shared Neighborhood Hits	41
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

STAM2_MOUSE
NC score	0.062075 (rank : 177)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	190	Target Neighborhood Hits	285	Shared Neighborhood Hits	54
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

PCTL_MOUSE
NC score	0.061935 (rank : 178)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	190	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JMD3	Gene names	Stard10, Pctpl, Sdccag28, Sdccagg28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28 homolog).

PCTL_HUMAN
NC score	0.061212 (rank : 179)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	190	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y365, O60532	Gene names	STARD10, SDCCAG28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28) (Antigen NY-CO-28).

DDEF2_MOUSE
NC score	0.061156 (rank : 180)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	190	Target Neighborhood Hits	625	Shared Neighborhood Hits	39
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

MPP6_HUMAN
NC score	0.061057 (rank : 181)	θ value	0.0961366 (rank : 100)
Query Neighborhood Hits	190	Target Neighborhood Hits	180	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

OSTF1_MOUSE
NC score	0.060876 (rank : 182)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	190	Target Neighborhood Hits	467	Shared Neighborhood Hits	50
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PIN1_MOUSE
NC score	0.060709 (rank : 183)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	190	Target Neighborhood Hits	60	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

NCF4_HUMAN
NC score	0.060552 (rank : 184)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	190	Target Neighborhood Hits	161	Shared Neighborhood Hits	26
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

ARHG9_MOUSE
NC score	0.060410 (rank : 185)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	190	Target Neighborhood Hits	234	Shared Neighborhood Hits	40
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG9_HUMAN
NC score	0.060218 (rank : 186)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	190	Target Neighborhood Hits	235	Shared Neighborhood Hits	40
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG4_HUMAN
NC score	0.060163 (rank : 187)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	190	Target Neighborhood Hits	242	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PLCG1_MOUSE
NC score	0.059996 (rank : 188)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	190	Target Neighborhood Hits	314	Shared Neighborhood Hits	58
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

HUWE1_MOUSE
NC score	0.059880 (rank : 189)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	190	Target Neighborhood Hits	406	Shared Neighborhood Hits	18
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

ABI1_MOUSE
NC score	0.059871 (rank : 190)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	190	Target Neighborhood Hits	246	Shared Neighborhood Hits	42
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

HUWE1_HUMAN
NC score	0.059789 (rank : 191)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	190	Target Neighborhood Hits	443	Shared Neighborhood Hits	17
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

SRC8_MOUSE
NC score	0.059645 (rank : 192)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	190	Target Neighborhood Hits	292	Shared Neighborhood Hits	43
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

PKHA5_HUMAN
NC score	0.059606 (rank : 193)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	190	Target Neighborhood Hits	455	Shared Neighborhood Hits	52
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PLCG1_HUMAN
NC score	0.059497 (rank : 194)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	190	Target Neighborhood Hits	293	Shared Neighborhood Hits	57
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

STAM2_HUMAN
NC score	0.059410 (rank : 195)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	190	Target Neighborhood Hits	288	Shared Neighborhood Hits	51
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

SPN90_MOUSE
NC score	0.059384 (rank : 196)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	190	Target Neighborhood Hits	157	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

YES_MOUSE
NC score	0.059359 (rank : 197)	θ value	0.000270298 (rank : 68)
Query Neighborhood Hits	190	Target Neighborhood Hits	1052	Shared Neighborhood Hits	62
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

PINL_HUMAN
NC score	0.058835 (rank : 198)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	190	Target Neighborhood Hits	47	Shared Neighborhood Hits	24
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

SRC8_HUMAN
NC score	0.058659 (rank : 199)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	190	Target Neighborhood Hits	269	Shared Neighborhood Hits	43
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SAV1_HUMAN
NC score	0.058580 (rank : 200)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	190	Target Neighborhood Hits	51	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

FGR_MOUSE
NC score	0.058464 (rank : 201)	θ value	0.0148317 (rank : 85)
Query Neighborhood Hits	190	Target Neighborhood Hits	1069	Shared Neighborhood Hits	62
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

PLCG2_HUMAN
NC score	0.058444 (rank : 202)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	190	Target Neighborhood Hits	280	Shared Neighborhood Hits	48
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

FGR_HUMAN
NC score	0.058416 (rank : 203)	θ value	0.00869519 (rank : 83)
Query Neighborhood Hits	190	Target Neighborhood Hits	1067	Shared Neighborhood Hits	63
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

K0317_HUMAN
NC score	0.058259 (rank : 204)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	190	Target Neighborhood Hits	46	Shared Neighborhood Hits	11
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
NC score	0.058196 (rank : 205)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	190	Target Neighborhood Hits	43	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

DDEF1_MOUSE
NC score	0.058165 (rank : 206)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	190	Target Neighborhood Hits	592	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

SAV1_MOUSE
NC score	0.058126 (rank : 207)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	190	Target Neighborhood Hits	48	Shared Neighborhood Hits	20
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

STAM1_MOUSE
NC score	0.058071 (rank : 208)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	190	Target Neighborhood Hits	273	Shared Neighborhood Hits	49
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

YES_HUMAN
NC score	0.058023 (rank : 209)	θ value	0.000602161 (rank : 72)
Query Neighborhood Hits	190	Target Neighborhood Hits	1059	Shared Neighborhood Hits	62
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

WWTR1_MOUSE
NC score	0.057968 (rank : 210)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	190	Target Neighborhood Hits	54	Shared Neighborhood Hits	20
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

ARHG6_MOUSE
NC score	0.057631 (rank : 211)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	190	Target Neighborhood Hits	394	Shared Neighborhood Hits	52
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

STAM1_HUMAN
NC score	0.057386 (rank : 212)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	190	Target Neighborhood Hits	271	Shared Neighborhood Hits	51
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

UN13B_HUMAN
NC score	0.056978 (rank : 213)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	190	Target Neighborhood Hits	217	Shared Neighborhood Hits	21
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

PACN2_HUMAN
NC score	0.056722 (rank : 214)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	190	Target Neighborhood Hits	339	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

MPP6_MOUSE
NC score	0.056592 (rank : 215)	θ value	0.813845 (rank : 124)
Query Neighborhood Hits	190	Target Neighborhood Hits	187	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

SH3G2_MOUSE
NC score	0.056500 (rank : 216)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	190	Target Neighborhood Hits	319	Shared Neighborhood Hits	49
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

PDZD8_HUMAN
NC score	0.056487 (rank : 217)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	190	Target Neighborhood Hits	185	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

HECD2_MOUSE
NC score	0.056285 (rank : 218)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	190	Target Neighborhood Hits	38	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

SH3G2_HUMAN
NC score	0.056255 (rank : 219)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	190	Target Neighborhood Hits	324	Shared Neighborhood Hits	52
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

ARHG6_HUMAN
NC score	0.056253 (rank : 220)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	190	Target Neighborhood Hits	376	Shared Neighborhood Hits	51
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

PKHA1_MOUSE
NC score	0.056233 (rank : 221)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	190	Target Neighborhood Hits	120	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

SH21B_MOUSE
NC score	0.056181 (rank : 222)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	190	Target Neighborhood Hits	101	Shared Neighborhood Hits	26
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

HECD2_HUMAN
NC score	0.055884 (rank : 223)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	190	Target Neighborhood Hits	41	Shared Neighborhood Hits	11
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

UN13A_HUMAN
NC score	0.055579 (rank : 224)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	190	Target Neighborhood Hits	285	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

PACN1_MOUSE
NC score	0.055258 (rank : 225)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	190	Target Neighborhood Hits	283	Shared Neighborhood Hits	49
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

BNIP2_HUMAN
NC score	0.055170 (rank : 226)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	190	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q12982	Gene names	BNIP2, NIP2
Domain Architecture
Description	BCL2/adenovirus E1B 19 kDa protein-interacting protein 2.

BNIP2_MOUSE
NC score	0.055128 (rank : 227)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	190	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	O54940	Gene names	Bnip2, Nip2l
Domain Architecture
Description	BCL2/adenovirus E1B 19 kDa protein-interacting protein 2.

PACN1_HUMAN
NC score	0.055107 (rank : 228)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	190	Target Neighborhood Hits	320	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

SRC_HUMAN
NC score	0.055088 (rank : 229)	θ value	0.00509761 (rank : 80)
Query Neighborhood Hits	190	Target Neighborhood Hits	1058	Shared Neighborhood Hits	61
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

FYN_MOUSE
NC score	0.054808 (rank : 230)	θ value	0.0193708 (rank : 90)
Query Neighborhood Hits	190	Target Neighborhood Hits	1073	Shared Neighborhood Hits	62
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

MYO1F_HUMAN
NC score	0.054430 (rank : 231)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	190	Target Neighborhood Hits	275	Shared Neighborhood Hits	49
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
NC score	0.054338 (rank : 232)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	190	Target Neighborhood Hits	262	Shared Neighborhood Hits	49
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

UBE3A_HUMAN
NC score	0.054036 (rank : 233)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	190	Target Neighborhood Hits	49	Shared Neighborhood Hits	11
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

MYO10_HUMAN
NC score	0.053799 (rank : 234)	θ value	1.06291 (rank : 127)
Query Neighborhood Hits	190	Target Neighborhood Hits	920	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

FA13A_MOUSE
NC score	0.053795 (rank : 235)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	190	Target Neighborhood Hits	83	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BGI4, Q8BZ91	Gene names	Fam13a1, Precm1
Domain Architecture	No domain graphic available
Description	Protein FAM13A1 (Precm1 protein).

PLEK_HUMAN
NC score	0.053773 (rank : 236)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	190	Target Neighborhood Hits	110	Shared Neighborhood Hits	15
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

UBE3A_MOUSE
NC score	0.053503 (rank : 237)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	190	Target Neighborhood Hits	47	Shared Neighborhood Hits	12
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

NCF1_MOUSE
NC score	0.053377 (rank : 238)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	190	Target Neighborhood Hits	198	Shared Neighborhood Hits	42
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

FYN_HUMAN
NC score	0.053309 (rank : 239)	θ value	0.0193708 (rank : 89)
Query Neighborhood Hits	190	Target Neighborhood Hits	1078	Shared Neighborhood Hits	63
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

UN13B_MOUSE
NC score	0.053203 (rank : 240)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	190	Target Neighborhood Hits	210	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

PIN1_HUMAN
NC score	0.053177 (rank : 241)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	190	Target Neighborhood Hits	59	Shared Neighborhood Hits	26
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PACN2_MOUSE
NC score	0.052963 (rank : 242)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	190	Target Neighborhood Hits	382	Shared Neighborhood Hits	49
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

UBE3C_HUMAN
NC score	0.052904 (rank : 243)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	190	Target Neighborhood Hits	51	Shared Neighborhood Hits	11
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

FA13A_HUMAN
NC score	0.052719 (rank : 244)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	190	Target Neighborhood Hits	102	Shared Neighborhood Hits	2
SwissProt Accessions	O94988, Q8NBA3	Gene names	FAM13A1, KIAA0914
Domain Architecture	No domain graphic available
Description	Protein FAM13A1.

UBE3C_MOUSE
NC score	0.052683 (rank : 245)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	190	Target Neighborhood Hits	48	Shared Neighborhood Hits	11
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

ATCAY_MOUSE
NC score	0.052527 (rank : 246)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	190	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BHE3, Q3TR94	Gene names	Atcay
Domain Architecture
Description	Caytaxin.

ABI1_HUMAN
NC score	0.052492 (rank : 247)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	190	Target Neighborhood Hits	257	Shared Neighborhood Hits	42
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

SH3G1_HUMAN
NC score	0.052466 (rank : 248)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	190	Target Neighborhood Hits	307	Shared Neighborhood Hits	47
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

DP13A_HUMAN
NC score	0.052324 (rank : 249)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	190	Target Neighborhood Hits	107	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

ACTN3_HUMAN
NC score	0.052318 (rank : 250)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	190	Target Neighborhood Hits	272	Shared Neighborhood Hits	12
SwissProt Accessions	Q08043	Gene names	ACTN3
Domain Architecture
Description	Alpha-actinin-3 (Alpha actinin skeletal muscle isoform 3) (F-actin cross-linking protein).

MYO1E_HUMAN
NC score	0.052163 (rank : 251)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	190	Target Neighborhood Hits	293	Shared Neighborhood Hits	49
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

ATCAY_HUMAN
NC score	0.052031 (rank : 252)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	190	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q86WG3, Q8NAQ2, Q8TAQ3, Q96HC6, Q96JF5	Gene names	ATCAY, KIAA1872
Domain Architecture
Description	Caytaxin (Ataxia Cayman type protein) (BNIP-H).

ACTN4_MOUSE
NC score	0.051859 (rank : 253)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	190	Target Neighborhood Hits	276	Shared Neighborhood Hits	13
SwissProt Accessions	P57780	Gene names	Actn4
Domain Architecture
Description	Alpha-actinin-4 (Non-muscle alpha-actinin 4) (F-actin cross-linking protein).

ACTN4_HUMAN
NC score	0.051847 (rank : 254)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	190	Target Neighborhood Hits	279	Shared Neighborhood Hits	11
SwissProt Accessions	O43707, O76048	Gene names	ACTN4
Domain Architecture
Description	Alpha-actinin-4 (Non-muscle alpha-actinin 4) (F-actin cross-linking protein).

ACTN1_MOUSE
NC score	0.051655 (rank : 255)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	190	Target Neighborhood Hits	216	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TPR4	Gene names	Actn1
Domain Architecture
Description	Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (Non-muscle alpha-actinin-1) (F-actin cross-linking protein).

ACTN3_MOUSE
NC score	0.051638 (rank : 256)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	190	Target Neighborhood Hits	265	Shared Neighborhood Hits	9
SwissProt Accessions	O88990	Gene names	Actn3
Domain Architecture
Description	Alpha-actinin-3 (Alpha actinin skeletal muscle isoform 3) (F-actin cross-linking protein).

TRIPC_HUMAN
NC score	0.051563 (rank : 257)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	190	Target Neighborhood Hits	319	Shared Neighborhood Hits	19
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

CENA2_HUMAN
NC score	0.051478 (rank : 258)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	190	Target Neighborhood Hits	83	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

ACTN1_HUMAN
NC score	0.051428 (rank : 259)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	190	Target Neighborhood Hits	221	Shared Neighborhood Hits	8
SwissProt Accessions	P12814, Q9BTN1	Gene names	ACTN1
Domain Architecture
Description	Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (Non-muscle alpha-actinin-1) (F-actin cross-linking protein).

WWC1_HUMAN
NC score	0.051197 (rank : 260)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	190	Target Neighborhood Hits	290	Shared Neighborhood Hits	30
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

BNIPL_MOUSE
NC score	0.050913 (rank : 261)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	190	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q99JU7, Q923E3	Gene names	Bnipl
Domain Architecture	No domain graphic available
Description	Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein.

BNIPL_HUMAN
NC score	0.050689 (rank : 262)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	190	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z465, Q6DK43, Q8TCY7, Q8WYG2	Gene names	BNIPL
Domain Architecture	No domain graphic available
Description	Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein.

HAPIP_HUMAN
NC score	0.050466 (rank : 263)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	190	Target Neighborhood Hits	350	Shared Neighborhood Hits	18
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

MAGI2_MOUSE
NC score	0.049909 (rank : 264)	θ value	1.38821 (rank : 135)
Query Neighborhood Hits	190	Target Neighborhood Hits	370	Shared Neighborhood Hits	32
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

MPP2_HUMAN
NC score	0.049610 (rank : 265)	θ value	0.0330416 (rank : 95)
Query Neighborhood Hits	190	Target Neighborhood Hits	173	Shared Neighborhood Hits	27
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

BTK_HUMAN
NC score	0.049334 (rank : 266)	θ value	0.0330416 (rank : 93)
Query Neighborhood Hits	190	Target Neighborhood Hits	1026	Shared Neighborhood Hits	56
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
NC score	0.048998 (rank : 267)	θ value	0.0193708 (rank : 88)
Query Neighborhood Hits	190	Target Neighborhood Hits	1017	Shared Neighborhood Hits	55
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

PTMS_HUMAN
NC score	0.048482 (rank : 268)	θ value	0.279714 (rank : 113)
Query Neighborhood Hits	190	Target Neighborhood Hits	111	Shared Neighborhood Hits	5
SwissProt Accessions	P20962	Gene names	PTMS
Domain Architecture	No domain graphic available
Description	Parathymosin.

MAGI1_HUMAN
NC score	0.048472 (rank : 269)	θ value	1.06291 (rank : 126)
Query Neighborhood Hits	190	Target Neighborhood Hits	388	Shared Neighborhood Hits	37
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

K1914_HUMAN
NC score	0.048280 (rank : 270)	θ value	0.21417 (rank : 107)
Query Neighborhood Hits	190	Target Neighborhood Hits	255	Shared Neighborhood Hits	13
SwissProt Accessions	Q8N4X5, Q8TB54, Q96PX4, Q96SY5	Gene names	KIAA1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

ES8L3_MOUSE
NC score	0.046451 (rank : 271)	θ value	2.36792 (rank : 140)
Query Neighborhood Hits	190	Target Neighborhood Hits	168	Shared Neighborhood Hits	38
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

SRC_MOUSE
NC score	0.045658 (rank : 272)	θ value	0.47712 (rank : 118)
Query Neighborhood Hits	190	Target Neighborhood Hits	1033	Shared Neighborhood Hits	57
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

MPP2_MOUSE
NC score	0.045304 (rank : 273)	θ value	0.279714 (rank : 112)
Query Neighborhood Hits	190	Target Neighborhood Hits	189	Shared Neighborhood Hits	28
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

ITK_HUMAN
NC score	0.045250 (rank : 274)	θ value	0.0330416 (rank : 94)
Query Neighborhood Hits	190	Target Neighborhood Hits	1016	Shared Neighborhood Hits	53
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

MAGI1_MOUSE
NC score	0.044842 (rank : 275)	θ value	8.99809 (rank : 184)
Query Neighborhood Hits	190	Target Neighborhood Hits	403	Shared Neighborhood Hits	37
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

K1914_MOUSE
NC score	0.043442 (rank : 276)	θ value	3.0926 (rank : 147)
Query Neighborhood Hits	190	Target Neighborhood Hits	216	Shared Neighborhood Hits	12
SwissProt Accessions	Q5DTU0, Q8BID1, Q8K2G0	Gene names	Kiaa1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

MAGI2_HUMAN
NC score	0.043068 (rank : 277)	θ value	5.27518 (rank : 165)
Query Neighborhood Hits	190	Target Neighborhood Hits	373	Shared Neighborhood Hits	29
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

TEC_HUMAN
NC score	0.042529 (rank : 278)	θ value	0.365318 (rank : 116)
Query Neighborhood Hits	190	Target Neighborhood Hits	1006	Shared Neighborhood Hits	54
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEC_MOUSE
NC score	0.042162 (rank : 279)	θ value	0.47712 (rank : 119)
Query Neighborhood Hits	190	Target Neighborhood Hits	1006	Shared Neighborhood Hits	56
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

HCK_HUMAN
NC score	0.041834 (rank : 280)	θ value	2.36792 (rank : 141)
Query Neighborhood Hits	190	Target Neighborhood Hits	1035	Shared Neighborhood Hits	53
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

TXK_HUMAN
NC score	0.041831 (rank : 281)	θ value	1.38821 (rank : 138)
Query Neighborhood Hits	190	Target Neighborhood Hits	971	Shared Neighborhood Hits	54
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

HCK_MOUSE
NC score	0.041116 (rank : 282)	θ value	0.813845 (rank : 123)
Query Neighborhood Hits	190	Target Neighborhood Hits	1029	Shared Neighborhood Hits	51
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

TXK_MOUSE
NC score	0.040879 (rank : 283)	θ value	4.03905 (rank : 161)
Query Neighborhood Hits	190	Target Neighborhood Hits	980	Shared Neighborhood Hits	56
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

HMBX1_HUMAN
NC score	0.040257 (rank : 284)	θ value	0.47712 (rank : 117)
Query Neighborhood Hits	190	Target Neighborhood Hits	118	Shared Neighborhood Hits	4
SwissProt Accessions	Q6NT76, Q3Y6P1, Q96GS5, Q9H701	Gene names	HMBOX1
Domain Architecture	No domain graphic available
Description	Homeobox-containing protein 1.

BLK_MOUSE
NC score	0.040238 (rank : 285)	θ value	4.03905 (rank : 151)
Query Neighborhood Hits	190	Target Neighborhood Hits	992	Shared Neighborhood Hits	50
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

ITK_MOUSE
NC score	0.040020 (rank : 286)	θ value	0.279714 (rank : 111)
Query Neighborhood Hits	190	Target Neighborhood Hits	985	Shared Neighborhood Hits	49
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

BLK_HUMAN
NC score	0.039313 (rank : 287)	θ value	2.36792 (rank : 139)
Query Neighborhood Hits	190	Target Neighborhood Hits	994	Shared Neighborhood Hits	50
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

HMBX1_MOUSE
NC score	0.038767 (rank : 288)	θ value	0.62314 (rank : 120)
Query Neighborhood Hits	190	Target Neighborhood Hits	117	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BJA3, Q80WC2, Q8BWE7, Q99LV1	Gene names	Hmbox1
Domain Architecture	No domain graphic available
Description	Homeobox-containing protein 1.

EM55_MOUSE
NC score	0.034471 (rank : 289)	θ value	5.27518 (rank : 164)
Query Neighborhood Hits	190	Target Neighborhood Hits	221	Shared Neighborhood Hits	29
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

SH24A_MOUSE
NC score	0.032713 (rank : 290)	θ value	1.38821 (rank : 136)
Query Neighborhood Hits	190	Target Neighborhood Hits	326	Shared Neighborhood Hits	25
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

FA44A_HUMAN
NC score	0.024906 (rank : 291)	θ value	0.279714 (rank : 110)
Query Neighborhood Hits	190	Target Neighborhood Hits	280	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NFC6, Q6P0M8	Gene names	FAM44A
Domain Architecture	No domain graphic available
Description	Protein FAM44A.

RCOR1_HUMAN
NC score	0.024674 (rank : 292)	θ value	1.06291 (rank : 129)
Query Neighborhood Hits	190	Target Neighborhood Hits	61	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UKL0, Q15044, Q6P2I9, Q86VG5	Gene names	RCOR1, KIAA0071, RCOR
Domain Architecture	No domain graphic available
Description	REST corepressor 1 (Protein CoREST).

RCOR1_MOUSE
NC score	0.024094 (rank : 293)	θ value	1.06291 (rank : 130)
Query Neighborhood Hits	190	Target Neighborhood Hits	55	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CFE3, Q3V092, Q8BK28, Q8CHI2	Gene names	Rcor1, D12Wsu95e, Kiaa0071
Domain Architecture	No domain graphic available
Description	REST corepressor 1 (Protein CoREST).

T4S5_HUMAN
NC score	0.024054 (rank : 294)	θ value	4.03905 (rank : 160)
Query Neighborhood Hits	190	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	O14894, Q6IB79	Gene names	TM4SF5
Domain Architecture
Description	Transmembrane 4 L6 family member 5 (Tetraspan transmembrane protein L6H).

SP100_MOUSE
NC score	0.019048 (rank : 295)	θ value	1.38821 (rank : 137)
Query Neighborhood Hits	190	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	O35892, O35897, O88392, O88395	Gene names	Sp100
Domain Architecture
Description	Nuclear autoantigen Sp-100 (Speckled 100 kDa) (Nuclear dot-associated Sp100 protein).

IQGA1_HUMAN
NC score	0.018853 (rank : 296)	θ value	4.03905 (rank : 155)
Query Neighborhood Hits	190	Target Neighborhood Hits	250	Shared Neighborhood Hits	14
SwissProt Accessions	P46940	Gene names	IQGAP1, KIAA0051
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP1 (p195).

CENPE_HUMAN
NC score	0.018006 (rank : 297)	θ value	6.88961 (rank : 170)
Query Neighborhood Hits	190	Target Neighborhood Hits	2060	Shared Neighborhood Hits	53
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

ARI1B_HUMAN
NC score	0.016456 (rank : 298)	θ value	8.99809 (rank : 181)
Query Neighborhood Hits	190	Target Neighborhood Hits	567	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

DACT1_MOUSE
NC score	0.015954 (rank : 299)	θ value	6.88961 (rank : 171)
Query Neighborhood Hits	190	Target Neighborhood Hits	93	Shared Neighborhood Hits	7
SwissProt Accessions	Q8R4A3, Q80VG9, Q8BP49, Q9JK89	Gene names	Dact1, Thyex3
Domain Architecture	No domain graphic available
Description	Dapper homolog 1 (MDpr1) (Frodo) (Thymus-expressed novel gene 3 protein).

CHD2_HUMAN
NC score	0.015447 (rank : 300)	θ value	0.0736092 (rank : 97)
Query Neighborhood Hits	190	Target Neighborhood Hits	360	Shared Neighborhood Hits	11
SwissProt Accessions	O14647	Gene names	CHD2
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 2 (EC 3.6.1.-) (ATP- dependent helicase CHD2) (CHD-2).

VP13B_HUMAN
NC score	0.015286 (rank : 301)	θ value	6.88961 (rank : 180)
Query Neighborhood Hits	190	Target Neighborhood Hits	78	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z7G8, Q709C6, Q709C7, Q7Z7G4, Q7Z7G5, Q7Z7G6, Q7Z7G7, Q8NB77, Q9NWV1, Q9Y4E7	Gene names	VPS13B, CHS1, COH1, KIAA0532
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associated protein 13B (Cohen syndrome protein 1).

RPTN_MOUSE
NC score	0.015110 (rank : 302)	θ value	0.365318 (rank : 115)
Query Neighborhood Hits	190	Target Neighborhood Hits	650	Shared Neighborhood Hits	15
SwissProt Accessions	P97347	Gene names	Rptn
Domain Architecture
Description	Repetin.

DACT1_HUMAN
NC score	0.014883 (rank : 303)	θ value	4.03905 (rank : 154)
Query Neighborhood Hits	190	Target Neighborhood Hits	228	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NYF0, Q86TY0	Gene names	DACT1, DPR1, HNG3
Domain Architecture	No domain graphic available
Description	Dapper homolog 1 (hDPR1) (Heptacellular carcinoma novel gene 3 protein).

CSKI2_MOUSE
NC score	0.014690 (rank : 304)	θ value	4.03905 (rank : 153)
Query Neighborhood Hits	190	Target Neighborhood Hits	812	Shared Neighborhood Hits	19
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

ELOA1_HUMAN
NC score	0.014562 (rank : 305)	θ value	3.0926 (rank : 145)
Query Neighborhood Hits	190	Target Neighborhood Hits	388	Shared Neighborhood Hits	16
SwissProt Accessions	Q14241, Q8IXH1	Gene names	TCEB3
Domain Architecture
Description	Transcription elongation factor B polypeptide 3 (RNA polymerase II transcription factor SIII subunit A1) (SIII p110) (Elongin-A) (EloA) (Elongin 110 kDa subunit).

PALM_MOUSE
NC score	0.014537 (rank : 306)	θ value	6.88961 (rank : 176)
Query Neighborhood Hits	190	Target Neighborhood Hits	228	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Z0P4, Q9Z0P3	Gene names	Palm
Domain Architecture
Description	Paralemmin.

CB013_MOUSE
NC score	0.013097 (rank : 307)	θ value	4.03905 (rank : 152)
Query Neighborhood Hits	190	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D842, Q8BZL5, Q99LX6	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf13 homolog.

CSKP_HUMAN
NC score	0.012902 (rank : 308)	θ value	3.0926 (rank : 144)
Query Neighborhood Hits	190	Target Neighborhood Hits	1022	Shared Neighborhood Hits	46
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

PRP4B_HUMAN
NC score	0.012686 (rank : 309)	θ value	4.03905 (rank : 159)
Query Neighborhood Hits	190	Target Neighborhood Hits	1030	Shared Neighborhood Hits	34
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

FHOD1_HUMAN
NC score	0.011928 (rank : 310)	θ value	3.0926 (rank : 146)
Query Neighborhood Hits	190	Target Neighborhood Hits	184	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y613, Q59F76, Q6Y1F2, Q76MS8, Q8N521	Gene names	FHOD1, FHOS
Domain Architecture
Description	FH1/FH2 domain-containing protein (Formin homolog overexpressed in spleen) (FHOS) (Formin homology 2 domain-containing protein 1).

CSPG2_MOUSE
NC score	0.011599 (rank : 311)	θ value	0.279714 (rank : 109)
Query Neighborhood Hits	190	Target Neighborhood Hits	711	Shared Neighborhood Hits	8
SwissProt Accessions	Q62059, Q62058, Q9CUU0	Gene names	Cspg2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M).

CSKP_MOUSE
NC score	0.011408 (rank : 312)	θ value	5.27518 (rank : 162)
Query Neighborhood Hits	190	Target Neighborhood Hits	1027	Shared Neighborhood Hits	44
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

SM1L2_MOUSE
NC score	0.010845 (rank : 313)	θ value	5.27518 (rank : 169)
Query Neighborhood Hits	190	Target Neighborhood Hits	918	Shared Neighborhood Hits	24
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

CYLC1_HUMAN
NC score	0.010728 (rank : 314)	θ value	5.27518 (rank : 163)
Query Neighborhood Hits	190	Target Neighborhood Hits	408	Shared Neighborhood Hits	16
SwissProt Accessions	P35663, Q5JQQ9	Gene names	CYLC1, CYL, CYL1
Domain Architecture	No domain graphic available
Description	Cylicin-1 (Cylicin I) (Multiple-band polypeptide I).

PGCA_MOUSE
NC score	0.010241 (rank : 315)	θ value	1.06291 (rank : 128)
Query Neighborhood Hits	190	Target Neighborhood Hits	643	Shared Neighborhood Hits	7
SwissProt Accessions	Q61282, Q64021	Gene names	Agc1, Agc
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP).

MB3L2_HUMAN
NC score	0.009843 (rank : 316)	θ value	6.88961 (rank : 175)
Query Neighborhood Hits	190	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NHZ7	Gene names	MBD3L2
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 3-like 2 (MBD3-like 2).

PCNT_MOUSE
NC score	0.009375 (rank : 317)	θ value	8.99809 (rank : 187)
Query Neighborhood Hits	190	Target Neighborhood Hits	1207	Shared Neighborhood Hits	19
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

MYT1_MOUSE
NC score	0.007507 (rank : 318)	θ value	4.03905 (rank : 157)
Query Neighborhood Hits	190	Target Neighborhood Hits	385	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CFC2, O08995, Q8CFH1	Gene names	Myt1, Kiaa0835, Nzf2
Domain Architecture	No domain graphic available
Description	Myelin transcription factor 1 (MyT1) (Neural zinc finger factor 2) (NZF-2).

TTK_MOUSE
NC score	0.006292 (rank : 319)	θ value	1.06291 (rank : 131)
Query Neighborhood Hits	190	Target Neighborhood Hits	803	Shared Neighborhood Hits	22
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

TTC28_MOUSE
NC score	0.006224 (rank : 320)	θ value	8.99809 (rank : 190)
Query Neighborhood Hits	190	Target Neighborhood Hits	194	Shared Neighborhood Hits	8
SwissProt Accessions	Q80XJ3, Q6P9J6, Q80TL5, Q8BV10, Q8C0F2	Gene names	Ttc28, Kiaa1043
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

UBP31_HUMAN
NC score	0.006163 (rank : 321)	θ value	6.88961 (rank : 178)
Query Neighborhood Hits	190	Target Neighborhood Hits	293	Shared Neighborhood Hits	8
SwissProt Accessions	Q70CQ4, Q6AW97, Q6ZTC0, Q6ZTN2, Q9ULL7	Gene names	USP31, KIAA1203
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.1.2.15) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) (Deubiquitinating enzyme 31).

NAPSA_HUMAN
NC score	0.005825 (rank : 322)	θ value	4.03905 (rank : 158)
Query Neighborhood Hits	190	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	O96009	Gene names	NAPSA, NAP1
Domain Architecture
Description	Napsin-A precursor (EC 3.4.23.-) (Napsin-1) (NAPA) (TA01/TA02) (Aspartyl protease 4) (Asp 4) (ASP4).

MYST4_HUMAN
NC score	0.005098 (rank : 323)	θ value	5.27518 (rank : 166)
Query Neighborhood Hits	190	Target Neighborhood Hits	671	Shared Neighborhood Hits	13
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

SEM6A_MOUSE
NC score	0.004816 (rank : 324)	θ value	3.0926 (rank : 149)
Query Neighborhood Hits	190	Target Neighborhood Hits	96	Shared Neighborhood Hits	4
SwissProt Accessions	O35464, Q6P5A8, Q6PCN9, Q9EQ71	Gene names	Sema6a, Semaq
Domain Architecture
Description	Semaphorin-6A precursor (Semaphorin VIA) (Sema VIA) (Semaphorin 6A-1) (SEMA6A-1) (Semaphorin Q) (Sema Q).

HBP1_HUMAN
NC score	0.004627 (rank : 325)	θ value	6.88961 (rank : 172)
Query Neighborhood Hits	190	Target Neighborhood Hits	89	Shared Neighborhood Hits	2
SwissProt Accessions	O60381, Q8TBM1, Q8TE93, Q96AJ2	Gene names	HBP1
Domain Architecture	No domain graphic available
Description	HMG box-containing protein 1 (HMG box transcription factor 1) (High mobility group box transcription factor 1).

OPA1_MOUSE
NC score	0.004513 (rank : 326)	θ value	8.99809 (rank : 186)
Query Neighborhood Hits	190	Target Neighborhood Hits	79	Shared Neighborhood Hits	4
SwissProt Accessions	P58281, Q3ULA5, Q8BKU7, Q8BLL3, Q8BM08, Q8R3J7	Gene names	Opa1
Domain Architecture
Description	Dynamin-like 120 kDa protein, mitochondrial precursor (Optic atrophy protein 1 homolog) (Large GTP-binding protein) (LargeG) [Contains: Dynamin-like 120 kDa protein, form S1].

SEM6A_HUMAN
NC score	0.004182 (rank : 327)	θ value	5.27518 (rank : 168)
Query Neighborhood Hits	190	Target Neighborhood Hits	96	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H2E6, Q9P2H9	Gene names	SEMA6A, KIAA1368
Domain Architecture
Description	Semaphorin-6A precursor (Semaphorin VIA) (Sema VIA) (Semaphorin 6A-1) (SEMA6A-1).

MKL2_MOUSE
NC score	0.004012 (rank : 328)	θ value	8.99809 (rank : 185)
Query Neighborhood Hits	190	Target Neighborhood Hits	269	Shared Neighborhood Hits	7
SwissProt Accessions	P59759	Gene names	Mkl2, Mrtfb
Domain Architecture
Description	MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B).

LEPR_MOUSE
NC score	0.003913 (rank : 329)	θ value	8.99809 (rank : 183)
Query Neighborhood Hits	190	Target Neighborhood Hits	109	Shared Neighborhood Hits	2
SwissProt Accessions	P48356, O35686, O54986, Q61215, Q64309, Q9QWG3, Q9QWV5	Gene names	Lepr, db, Obr
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (B219) (CD295 antigen).

LAP2_MOUSE
NC score	0.000963 (rank : 330)	θ value	6.88961 (rank : 174)
Query Neighborhood Hits	190	Target Neighborhood Hits	482	Shared Neighborhood Hits	10
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

KS6C1_MOUSE
NC score	0.000021 (rank : 331)	θ value	8.99809 (rank : 182)
Query Neighborhood Hits	190	Target Neighborhood Hits	700	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

LRIG2_HUMAN
NC score	-0.002649 (rank : 332)	θ value	4.03905 (rank : 156)
Query Neighborhood Hits	190	Target Neighborhood Hits	595	Shared Neighborhood Hits	4
SwissProt Accessions	O94898, Q9NSN2	Gene names	LRIG2, KIAA0806, LIG2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor (LIG-2).