Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : BCR_HUMAN

For an explanation of this page, click here

BCR_HUMAN
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ABR_HUMAN
θ value	0 (rank : 1)	NC score	0.980929 (rank : 2)
Query Neighborhood Hits	204	Target Neighborhood Hits	166	Shared Neighborhood Hits	134
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

BCR_HUMAN
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	204	Target Neighborhood Hits	204	Shared Neighborhood Hits	204
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

CHIN_MOUSE
θ value	1.6813e-30 (rank : 3)	NC score	0.685514 (rank : 18)
Query Neighborhood Hits	204	Target Neighborhood Hits	229	Shared Neighborhood Hits	72
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_HUMAN
θ value	6.38894e-30 (rank : 4)	NC score	0.685547 (rank : 17)
Query Neighborhood Hits	204	Target Neighborhood Hits	227	Shared Neighborhood Hits	72
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

RHG12_MOUSE
θ value	6.61148e-27 (rank : 5)	NC score	0.724094 (rank : 5)
Query Neighborhood Hits	204	Target Neighborhood Hits	204	Shared Neighborhood Hits	65
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

CHIO_MOUSE
θ value	1.12775e-26 (rank : 6)	NC score	0.709550 (rank : 12)
Query Neighborhood Hits	204	Target Neighborhood Hits	130	Shared Neighborhood Hits	70
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

RHG12_HUMAN
θ value	1.12775e-26 (rank : 7)	NC score	0.726408 (rank : 4)
Query Neighborhood Hits	204	Target Neighborhood Hits	190	Shared Neighborhood Hits	65
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

CHIO_HUMAN
θ value	3.28125e-26 (rank : 8)	NC score	0.681042 (rank : 19)
Query Neighborhood Hits	204	Target Neighborhood Hits	220	Shared Neighborhood Hits	71
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

RBP1_HUMAN
θ value	3.39556e-23 (rank : 9)	NC score	0.638423 (rank : 38)
Query Neighborhood Hits	204	Target Neighborhood Hits	521	Shared Neighborhood Hits	67
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RBP1_MOUSE
θ value	4.43474e-23 (rank : 10)	NC score	0.653823 (rank : 31)
Query Neighborhood Hits	204	Target Neighborhood Hits	493	Shared Neighborhood Hits	67
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

ARHGA_HUMAN
θ value	4.9032e-22 (rank : 11)	NC score	0.474541 (rank : 58)
Query Neighborhood Hits	204	Target Neighborhood Hits	187	Shared Neighborhood Hits	65
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

3BP1_HUMAN
θ value	8.36355e-22 (rank : 12)	NC score	0.704113 (rank : 14)
Query Neighborhood Hits	204	Target Neighborhood Hits	376	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

GRLF1_HUMAN
θ value	1.42661e-21 (rank : 13)	NC score	0.705454 (rank : 13)
Query Neighborhood Hits	204	Target Neighborhood Hits	167	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

TCGAP_HUMAN
θ value	5.42112e-21 (rank : 14)	NC score	0.640773 (rank : 36)
Query Neighborhood Hits	204	Target Neighborhood Hits	872	Shared Neighborhood Hits	104
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	5.42112e-21 (rank : 15)	NC score	0.718903 (rank : 6)
Query Neighborhood Hits	204	Target Neighborhood Hits	409	Shared Neighborhood Hits	99
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

MYO9B_MOUSE
θ value	7.0802e-21 (rank : 16)	NC score	0.373603 (rank : 79)
Query Neighborhood Hits	204	Target Neighborhood Hits	311	Shared Neighborhood Hits	78
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

RHG05_MOUSE
θ value	7.0802e-21 (rank : 17)	NC score	0.680452 (rank : 20)
Query Neighborhood Hits	204	Target Neighborhood Hits	165	Shared Neighborhood Hits	64
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG05_HUMAN
θ value	2.06002e-20 (rank : 18)	NC score	0.672102 (rank : 22)
Query Neighborhood Hits	204	Target Neighborhood Hits	158	Shared Neighborhood Hits	62
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RGAP1_HUMAN
θ value	2.69047e-20 (rank : 19)	NC score	0.718298 (rank : 8)
Query Neighborhood Hits	204	Target Neighborhood Hits	189	Shared Neighborhood Hits	68
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

MYO9B_HUMAN
θ value	4.58923e-20 (rank : 20)	NC score	0.369371 (rank : 83)
Query Neighborhood Hits	204	Target Neighborhood Hits	641	Shared Neighborhood Hits	89
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

SRGP1_HUMAN
θ value	5.99374e-20 (rank : 21)	NC score	0.647592 (rank : 34)
Query Neighborhood Hits	204	Target Neighborhood Hits	390	Shared Neighborhood Hits	81
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

ARHGA_MOUSE
θ value	7.82807e-20 (rank : 22)	NC score	0.474625 (rank : 57)
Query Neighborhood Hits	204	Target Neighborhood Hits	125	Shared Neighborhood Hits	60
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

RHG09_HUMAN
θ value	1.33526e-19 (rank : 23)	NC score	0.752034 (rank : 3)
Query Neighborhood Hits	204	Target Neighborhood Hits	186	Shared Neighborhood Hits	71
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

GMIP_HUMAN
θ value	1.74391e-19 (rank : 24)	NC score	0.716255 (rank : 10)
Query Neighborhood Hits	204	Target Neighborhood Hits	225	Shared Neighborhood Hits	72
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

RHG26_HUMAN
θ value	1.74391e-19 (rank : 25)	NC score	0.668015 (rank : 24)
Query Neighborhood Hits	204	Target Neighborhood Hits	281	Shared Neighborhood Hits	80
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

SRGP2_HUMAN
θ value	2.97466e-19 (rank : 26)	NC score	0.656199 (rank : 29)
Query Neighborhood Hits	204	Target Neighborhood Hits	331	Shared Neighborhood Hits	82
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

GMIP_MOUSE
θ value	6.62687e-19 (rank : 27)	NC score	0.718338 (rank : 7)
Query Neighborhood Hits	204	Target Neighborhood Hits	202	Shared Neighborhood Hits	74
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

SRGP2_MOUSE
θ value	1.13037e-18 (rank : 28)	NC score	0.649705 (rank : 33)
Query Neighborhood Hits	204	Target Neighborhood Hits	324	Shared Neighborhood Hits	81
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

FNBP2_HUMAN
θ value	1.47631e-18 (rank : 29)	NC score	0.638779 (rank : 37)
Query Neighborhood Hits	204	Target Neighborhood Hits	432	Shared Neighborhood Hits	81
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

ECT2_MOUSE
θ value	4.29542e-18 (rank : 30)	NC score	0.475836 (rank : 56)
Query Neighborhood Hits	204	Target Neighborhood Hits	98	Shared Neighborhood Hits	62
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

3BP1_MOUSE
θ value	5.60996e-18 (rank : 31)	NC score	0.711048 (rank : 11)
Query Neighborhood Hits	204	Target Neighborhood Hits	238	Shared Neighborhood Hits	78
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

RHG04_HUMAN
θ value	5.60996e-18 (rank : 32)	NC score	0.673829 (rank : 21)
Query Neighborhood Hits	204	Target Neighborhood Hits	307	Shared Neighborhood Hits	80
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

CEND2_HUMAN
θ value	6.20254e-17 (rank : 33)	NC score	0.570079 (rank : 42)
Query Neighborhood Hits	204	Target Neighborhood Hits	166	Shared Neighborhood Hits	71
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

ECT2_HUMAN
θ value	6.20254e-17 (rank : 34)	NC score	0.468695 (rank : 60)
Query Neighborhood Hits	204	Target Neighborhood Hits	98	Shared Neighborhood Hits	63
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

GNRP_MOUSE
θ value	8.10077e-17 (rank : 35)	NC score	0.372991 (rank : 81)
Query Neighborhood Hits	204	Target Neighborhood Hits	191	Shared Neighborhood Hits	58
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

PREX1_HUMAN
θ value	1.38178e-16 (rank : 36)	NC score	0.438653 (rank : 61)
Query Neighborhood Hits	204	Target Neighborhood Hits	177	Shared Neighborhood Hits	64
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

RGAP1_MOUSE
θ value	1.80466e-16 (rank : 37)	NC score	0.717550 (rank : 9)
Query Neighborhood Hits	204	Target Neighborhood Hits	185	Shared Neighborhood Hits	68
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

FGD6_MOUSE
θ value	5.25075e-16 (rank : 38)	NC score	0.410662 (rank : 70)
Query Neighborhood Hits	204	Target Neighborhood Hits	282	Shared Neighborhood Hits	67
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

RHG25_MOUSE
θ value	5.25075e-16 (rank : 39)	NC score	0.644152 (rank : 35)
Query Neighborhood Hits	204	Target Neighborhood Hits	492	Shared Neighborhood Hits	78
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

FGD6_HUMAN
θ value	1.16975e-15 (rank : 40)	NC score	0.409511 (rank : 71)
Query Neighborhood Hits	204	Target Neighborhood Hits	237	Shared Neighborhood Hits	62
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

RHG25_HUMAN
θ value	5.8054e-15 (rank : 41)	NC score	0.621112 (rank : 39)
Query Neighborhood Hits	204	Target Neighborhood Hits	550	Shared Neighborhood Hits	74
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

OPHN1_MOUSE
θ value	7.58209e-15 (rank : 42)	NC score	0.667640 (rank : 27)
Query Neighborhood Hits	204	Target Neighborhood Hits	174	Shared Neighborhood Hits	66
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

OPHN1_HUMAN
θ value	2.20605e-14 (rank : 43)	NC score	0.667982 (rank : 26)
Query Neighborhood Hits	204	Target Neighborhood Hits	161	Shared Neighborhood Hits	65
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

RHG06_HUMAN
θ value	2.20605e-14 (rank : 44)	NC score	0.693040 (rank : 15)
Query Neighborhood Hits	204	Target Neighborhood Hits	114	Shared Neighborhood Hits	66
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG06_MOUSE
θ value	6.41864e-14 (rank : 45)	NC score	0.691886 (rank : 16)
Query Neighborhood Hits	204	Target Neighborhood Hits	105	Shared Neighborhood Hits	63
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

CEND3_MOUSE
θ value	1.09485e-13 (rank : 46)	NC score	0.535814 (rank : 51)
Query Neighborhood Hits	204	Target Neighborhood Hits	228	Shared Neighborhood Hits	68
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

GNRP_HUMAN
θ value	1.09485e-13 (rank : 47)	NC score	0.353892 (rank : 86)
Query Neighborhood Hits	204	Target Neighborhood Hits	239	Shared Neighborhood Hits	58
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

CEND3_HUMAN
θ value	1.86753e-13 (rank : 48)	NC score	0.526540 (rank : 52)
Query Neighborhood Hits	204	Target Neighborhood Hits	275	Shared Neighborhood Hits	72
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CEND1_MOUSE
θ value	2.43908e-13 (rank : 49)	NC score	0.492928 (rank : 53)
Query Neighborhood Hits	204	Target Neighborhood Hits	260	Shared Neighborhood Hits	67
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

RHG07_MOUSE
θ value	2.43908e-13 (rank : 50)	NC score	0.601564 (rank : 40)
Query Neighborhood Hits	204	Target Neighborhood Hits	103	Shared Neighborhood Hits	62
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

RHG07_HUMAN
θ value	5.43371e-13 (rank : 51)	NC score	0.595577 (rank : 41)
Query Neighborhood Hits	204	Target Neighborhood Hits	108	Shared Neighborhood Hits	62
SwissProt Accessions	Q96QB1, O14868, O43199, Q9C0E0	Gene names	DLC1, ARHGAP7, KIAA1723, STARD12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

RHG01_HUMAN
θ value	7.09661e-13 (rank : 52)	NC score	0.663466 (rank : 28)
Query Neighborhood Hits	204	Target Neighborhood Hits	75	Shared Neighborhood Hits	63
SwissProt Accessions	Q07960	Gene names	ARHGAP1, CDC42GAP, RHOGAP1
Domain Architecture
Description	Rho-GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (CDC42 GTPase-activating protein) (p50-RhoGAP).

RHG08_MOUSE
θ value	7.09661e-13 (rank : 53)	NC score	0.655575 (rank : 30)
Query Neighborhood Hits	204	Target Neighborhood Hits	73	Shared Neighborhood Hits	62
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

FGD2_HUMAN
θ value	9.26847e-13 (rank : 54)	NC score	0.428753 (rank : 63)
Query Neighborhood Hits	204	Target Neighborhood Hits	151	Shared Neighborhood Hits	63
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

RHG08_HUMAN
θ value	9.26847e-13 (rank : 55)	NC score	0.650634 (rank : 32)
Query Neighborhood Hits	204	Target Neighborhood Hits	88	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NSG0, O75983, O95695, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NVX8, Q9NXL1, Q9UH20	Gene names	ARHGAP8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

RHG18_MOUSE
θ value	1.58096e-12 (rank : 56)	NC score	0.668006 (rank : 25)
Query Neighborhood Hits	204	Target Neighborhood Hits	110	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

ITSN1_MOUSE
θ value	2.0648e-12 (rank : 57)	NC score	0.278044 (rank : 115)
Query Neighborhood Hits	204	Target Neighborhood Hits	1669	Shared Neighborhood Hits	112
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

FGD1_MOUSE
θ value	2.69671e-12 (rank : 58)	NC score	0.411132 (rank : 69)
Query Neighborhood Hits	204	Target Neighborhood Hits	387	Shared Neighborhood Hits	72
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD4_MOUSE
θ value	4.59992e-12 (rank : 59)	NC score	0.425695 (rank : 64)
Query Neighborhood Hits	204	Target Neighborhood Hits	227	Shared Neighborhood Hits	68
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

STAR8_MOUSE
θ value	6.00763e-12 (rank : 60)	NC score	0.568653 (rank : 43)
Query Neighborhood Hits	204	Target Neighborhood Hits	101	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

FGD1_HUMAN
θ value	7.84624e-12 (rank : 61)	NC score	0.411898 (rank : 68)
Query Neighborhood Hits	204	Target Neighborhood Hits	367	Shared Neighborhood Hits	74
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ITSN1_HUMAN
θ value	1.33837e-11 (rank : 62)	NC score	0.278658 (rank : 113)
Query Neighborhood Hits	204	Target Neighborhood Hits	1757	Shared Neighborhood Hits	113
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

FGD3_MOUSE
θ value	2.98157e-11 (rank : 63)	NC score	0.434823 (rank : 62)
Query Neighborhood Hits	204	Target Neighborhood Hits	257	Shared Neighborhood Hits	63
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD2_MOUSE
θ value	5.08577e-11 (rank : 64)	NC score	0.418923 (rank : 67)
Query Neighborhood Hits	204	Target Neighborhood Hits	163	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD4_HUMAN
θ value	5.08577e-11 (rank : 65)	NC score	0.423895 (rank : 65)
Query Neighborhood Hits	204	Target Neighborhood Hits	219	Shared Neighborhood Hits	67
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

STAR8_HUMAN
θ value	5.08577e-11 (rank : 66)	NC score	0.562763 (rank : 45)
Query Neighborhood Hits	204	Target Neighborhood Hits	216	Shared Neighborhood Hits	66
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

CEND1_HUMAN
θ value	6.64225e-11 (rank : 67)	NC score	0.471490 (rank : 59)
Query Neighborhood Hits	204	Target Neighborhood Hits	284	Shared Neighborhood Hits	68
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

ITSN2_HUMAN
θ value	8.67504e-11 (rank : 68)	NC score	0.293872 (rank : 106)
Query Neighborhood Hits	204	Target Neighborhood Hits	1173	Shared Neighborhood Hits	96
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

STA13_HUMAN
θ value	1.9326e-10 (rank : 69)	NC score	0.563220 (rank : 44)
Query Neighborhood Hits	204	Target Neighborhood Hits	89	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

ITSN2_MOUSE
θ value	3.29651e-10 (rank : 70)	NC score	0.278608 (rank : 114)
Query Neighborhood Hits	204	Target Neighborhood Hits	1371	Shared Neighborhood Hits	99
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

FGD3_HUMAN
θ value	1.63604e-09 (rank : 71)	NC score	0.422045 (rank : 66)
Query Neighborhood Hits	204	Target Neighborhood Hits	249	Shared Neighborhood Hits	62
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

STA13_MOUSE
θ value	2.13673e-09 (rank : 72)	NC score	0.553312 (rank : 46)
Query Neighborhood Hits	204	Target Neighborhood Hits	89	Shared Neighborhood Hits	58
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

RHG18_HUMAN
θ value	6.21693e-09 (rank : 73)	NC score	0.671531 (rank : 23)
Query Neighborhood Hits	204	Target Neighborhood Hits	90	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

P85A_HUMAN
θ value	1.80886e-08 (rank : 74)	NC score	0.375376 (rank : 78)
Query Neighborhood Hits	204	Target Neighborhood Hits	479	Shared Neighborhood Hits	73
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

CE005_HUMAN
θ value	2.36244e-08 (rank : 75)	NC score	0.545947 (rank : 49)
Query Neighborhood Hits	204	Target Neighborhood Hits	213	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

CE005_MOUSE
θ value	2.36244e-08 (rank : 76)	NC score	0.542872 (rank : 50)
Query Neighborhood Hits	204	Target Neighborhood Hits	238	Shared Neighborhood Hits	62
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

FARP2_HUMAN
θ value	4.0297e-08 (rank : 77)	NC score	0.285152 (rank : 109)
Query Neighborhood Hits	204	Target Neighborhood Hits	240	Shared Neighborhood Hits	67
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
θ value	6.87365e-08 (rank : 78)	NC score	0.296469 (rank : 105)
Query Neighborhood Hits	204	Target Neighborhood Hits	209	Shared Neighborhood Hits	71
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

K1688_HUMAN
θ value	8.97725e-08 (rank : 79)	NC score	0.478155 (rank : 55)
Query Neighborhood Hits	204	Target Neighborhood Hits	217	Shared Neighborhood Hits	65
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

ARHG3_MOUSE
θ value	1.99992e-07 (rank : 80)	NC score	0.371588 (rank : 82)
Query Neighborhood Hits	204	Target Neighborhood Hits	85	Shared Neighborhood Hits	57
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG4_HUMAN
θ value	1.99992e-07 (rank : 81)	NC score	0.400404 (rank : 72)
Query Neighborhood Hits	204	Target Neighborhood Hits	242	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG3_HUMAN
θ value	2.61198e-07 (rank : 82)	NC score	0.373221 (rank : 80)
Query Neighborhood Hits	204	Target Neighborhood Hits	82	Shared Neighborhood Hits	57
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG4_MOUSE
θ value	2.61198e-07 (rank : 83)	NC score	0.397934 (rank : 73)
Query Neighborhood Hits	204	Target Neighborhood Hits	185	Shared Neighborhood Hits	63
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG8_HUMAN
θ value	2.61198e-07 (rank : 84)	NC score	0.377787 (rank : 77)
Query Neighborhood Hits	204	Target Neighborhood Hits	85	Shared Neighborhood Hits	60
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

K1688_MOUSE
θ value	2.61198e-07 (rank : 85)	NC score	0.484493 (rank : 54)
Query Neighborhood Hits	204	Target Neighborhood Hits	188	Shared Neighborhood Hits	61
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

DNMBP_MOUSE
θ value	3.41135e-07 (rank : 86)	NC score	0.334970 (rank : 91)
Query Neighborhood Hits	204	Target Neighborhood Hits	435	Shared Neighborhood Hits	83
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_HUMAN
θ value	4.45536e-07 (rank : 87)	NC score	0.327547 (rank : 94)
Query Neighborhood Hits	204	Target Neighborhood Hits	413	Shared Neighborhood Hits	76
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DUET_HUMAN
θ value	4.92598e-06 (rank : 88)	NC score	0.120086 (rank : 143)
Query Neighborhood Hits	204	Target Neighborhood Hits	1220	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

FGD5_HUMAN
θ value	4.92598e-06 (rank : 89)	NC score	0.331097 (rank : 93)
Query Neighborhood Hits	204	Target Neighborhood Hits	235	Shared Neighborhood Hits	50
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

PKHG1_HUMAN
θ value	4.92598e-06 (rank : 90)	NC score	0.390750 (rank : 74)
Query Neighborhood Hits	204	Target Neighborhood Hits	174	Shared Neighborhood Hits	62
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHG9_HUMAN
θ value	8.40245e-06 (rank : 91)	NC score	0.389910 (rank : 75)
Query Neighborhood Hits	204	Target Neighborhood Hits	235	Shared Neighborhood Hits	68
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	8.40245e-06 (rank : 92)	NC score	0.389699 (rank : 76)
Query Neighborhood Hits	204	Target Neighborhood Hits	234	Shared Neighborhood Hits	68
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

MCF2_HUMAN
θ value	8.40245e-06 (rank : 93)	NC score	0.342094 (rank : 88)
Query Neighborhood Hits	204	Target Neighborhood Hits	166	Shared Neighborhood Hits	61
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

TRIO_HUMAN
θ value	1.09739e-05 (rank : 94)	NC score	0.111287 (rank : 152)
Query Neighborhood Hits	204	Target Neighborhood Hits	1580	Shared Neighborhood Hits	79
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

VAV3_HUMAN
θ value	1.43324e-05 (rank : 95)	NC score	0.296568 (rank : 104)
Query Neighborhood Hits	204	Target Neighborhood Hits	398	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	3.19293e-05 (rank : 96)	NC score	0.298473 (rank : 103)
Query Neighborhood Hits	204	Target Neighborhood Hits	404	Shared Neighborhood Hits	81
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ARHG8_MOUSE
θ value	5.44631e-05 (rank : 97)	NC score	0.346537 (rank : 87)
Query Neighborhood Hits	204	Target Neighborhood Hits	79	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHG5_HUMAN
θ value	0.000121331 (rank : 98)	NC score	0.360649 (rank : 85)
Query Neighborhood Hits	204	Target Neighborhood Hits	172	Shared Neighborhood Hits	65
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

HAPIP_HUMAN
θ value	0.000158464 (rank : 99)	NC score	0.293617 (rank : 107)
Query Neighborhood Hits	204	Target Neighborhood Hits	350	Shared Neighborhood Hits	63
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ARHG7_MOUSE
θ value	0.00020696 (rank : 100)	NC score	0.314255 (rank : 99)
Query Neighborhood Hits	204	Target Neighborhood Hits	396	Shared Neighborhood Hits	69
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

FGD5_MOUSE
θ value	0.000270298 (rank : 101)	NC score	0.315493 (rank : 98)
Query Neighborhood Hits	204	Target Neighborhood Hits	170	Shared Neighborhood Hits	46
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

ARHGG_MOUSE
θ value	0.00035302 (rank : 102)	NC score	0.340389 (rank : 89)
Query Neighborhood Hits	204	Target Neighborhood Hits	152	Shared Neighborhood Hits	62
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG6_HUMAN
θ value	0.000461057 (rank : 103)	NC score	0.279207 (rank : 112)
Query Neighborhood Hits	204	Target Neighborhood Hits	376	Shared Neighborhood Hits	60
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

P85A_MOUSE
θ value	0.000786445 (rank : 104)	NC score	0.364045 (rank : 84)
Query Neighborhood Hits	204	Target Neighborhood Hits	435	Shared Neighborhood Hits	73
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

VAV_MOUSE
θ value	0.000786445 (rank : 105)	NC score	0.280755 (rank : 111)
Query Neighborhood Hits	204	Target Neighborhood Hits	430	Shared Neighborhood Hits	84
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ARHG7_HUMAN
θ value	0.00175202 (rank : 106)	NC score	0.307991 (rank : 101)
Query Neighborhood Hits	204	Target Neighborhood Hits	347	Shared Neighborhood Hits	70
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

I5P2_HUMAN
θ value	0.00228821 (rank : 107)	NC score	0.292456 (rank : 108)
Query Neighborhood Hits	204	Target Neighborhood Hits	86	Shared Neighborhood Hits	52
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

ARHGF_HUMAN
θ value	0.00390308 (rank : 108)	NC score	0.311839 (rank : 100)
Query Neighborhood Hits	204	Target Neighborhood Hits	214	Shared Neighborhood Hits	71
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHG6_MOUSE
θ value	0.00509761 (rank : 109)	NC score	0.268054 (rank : 120)
Query Neighborhood Hits	204	Target Neighborhood Hits	394	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHGB_HUMAN
θ value	0.00509761 (rank : 110)	NC score	0.270887 (rank : 116)
Query Neighborhood Hits	204	Target Neighborhood Hits	375	Shared Neighborhood Hits	64
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

FARP1_HUMAN
θ value	0.00509761 (rank : 111)	NC score	0.252895 (rank : 124)
Query Neighborhood Hits	204	Target Neighborhood Hits	241	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

P85B_MOUSE
θ value	0.00665767 (rank : 112)	NC score	0.112686 (rank : 150)
Query Neighborhood Hits	204	Target Neighborhood Hits	519	Shared Neighborhood Hits	34
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

ARHGG_HUMAN
θ value	0.0113563 (rank : 113)	NC score	0.335339 (rank : 90)
Query Neighborhood Hits	204	Target Neighborhood Hits	129	Shared Neighborhood Hits	61
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

CF150_HUMAN
θ value	0.0113563 (rank : 114)	NC score	0.068069 (rank : 222)
Query Neighborhood Hits	204	Target Neighborhood Hits	96	Shared Neighborhood Hits	11
SwissProt Accessions	Q8N884, Q32NC9, Q5SWL0, Q5SWL1, Q96E45	Gene names	C6orf150
Domain Architecture	No domain graphic available
Description	Protein C6orf150.

MCF2L_MOUSE
θ value	0.0193708 (rank : 115)	NC score	0.307327 (rank : 102)
Query Neighborhood Hits	204	Target Neighborhood Hits	255	Shared Neighborhood Hits	62
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

OCRL_HUMAN
θ value	0.0252991 (rank : 116)	NC score	0.281142 (rank : 110)
Query Neighborhood Hits	204	Target Neighborhood Hits	77	Shared Neighborhood Hits	51
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).

NGEF_HUMAN
θ value	0.0961366 (rank : 117)	NC score	0.331444 (rank : 92)
Query Neighborhood Hits	204	Target Neighborhood Hits	166	Shared Neighborhood Hits	63
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	0.0961366 (rank : 118)	NC score	0.322927 (rank : 97)
Query Neighborhood Hits	204	Target Neighborhood Hits	228	Shared Neighborhood Hits	65
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHG1_MOUSE
θ value	0.125558 (rank : 119)	NC score	0.253980 (rank : 123)
Query Neighborhood Hits	204	Target Neighborhood Hits	266	Shared Neighborhood Hits	57
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

MUC1_HUMAN
θ value	0.125558 (rank : 120)	NC score	0.022627 (rank : 299)
Query Neighborhood Hits	204	Target Neighborhood Hits	975	Shared Neighborhood Hits	27
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

P85B_HUMAN
θ value	0.163984 (rank : 121)	NC score	0.138169 (rank : 137)
Query Neighborhood Hits	204	Target Neighborhood Hits	543	Shared Neighborhood Hits	38
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

LRP6_HUMAN
θ value	0.279714 (rank : 122)	NC score	0.012265 (rank : 320)
Query Neighborhood Hits	204	Target Neighborhood Hits	235	Shared Neighborhood Hits	3
SwissProt Accessions	O75581	Gene names	LRP6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

LRP6_MOUSE
θ value	0.279714 (rank : 123)	NC score	0.012308 (rank : 319)
Query Neighborhood Hits	204	Target Neighborhood Hits	232	Shared Neighborhood Hits	3
SwissProt Accessions	O88572	Gene names	Lrp6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

MLL2_HUMAN
θ value	0.279714 (rank : 124)	NC score	0.027279 (rank : 292)
Query Neighborhood Hits	204	Target Neighborhood Hits	1788	Shared Neighborhood Hits	45
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

OBSCN_HUMAN
θ value	0.279714 (rank : 125)	NC score	0.048887 (rank : 282)
Query Neighborhood Hits	204	Target Neighborhood Hits	1931	Shared Neighborhood Hits	72
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

ZN142_HUMAN
θ value	0.279714 (rank : 126)	NC score	-0.004194 (rank : 349)
Query Neighborhood Hits	204	Target Neighborhood Hits	1007	Shared Neighborhood Hits	20
SwissProt Accessions	P52746, Q92510	Gene names	ZNF142, KIAA0236
Domain Architecture	No domain graphic available
Description	Zinc finger protein 142 (HA4654).

ARHG1_HUMAN
θ value	0.365318 (rank : 127)	NC score	0.268685 (rank : 118)
Query Neighborhood Hits	204	Target Neighborhood Hits	176	Shared Neighborhood Hits	55
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

GRIN1_HUMAN
θ value	0.365318 (rank : 128)	NC score	0.026481 (rank : 293)
Query Neighborhood Hits	204	Target Neighborhood Hits	681	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

SOX13_HUMAN
θ value	0.365318 (rank : 129)	NC score	0.018906 (rank : 309)
Query Neighborhood Hits	204	Target Neighborhood Hits	464	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UN79, O95275, O95826, Q9UHW7	Gene names	SOX13
Domain Architecture
Description	SOX-13 protein (Type 1 diabetes autoantigen ICA12) (Islet cell antigen 12).

TAGAP_HUMAN
θ value	0.365318 (rank : 130)	NC score	0.550174 (rank : 47)
Query Neighborhood Hits	204	Target Neighborhood Hits	82	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

PSL1_HUMAN
θ value	0.47712 (rank : 131)	NC score	0.025758 (rank : 294)
Query Neighborhood Hits	204	Target Neighborhood Hits	650	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

PKHG4_HUMAN
θ value	0.62314 (rank : 132)	NC score	0.263056 (rank : 122)
Query Neighborhood Hits	204	Target Neighborhood Hits	200	Shared Neighborhood Hits	53
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

NXF2_HUMAN
θ value	0.813845 (rank : 133)	NC score	0.023132 (rank : 297)
Query Neighborhood Hits	204	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	Q9GZY0, Q9BXU4, Q9NSS1, Q9NX66	Gene names	NXF2, TAPL2
Domain Architecture
Description	Nuclear RNA export factor 2 (TAP-like protein 2) (TAPL-2).

SYT1_HUMAN
θ value	0.813845 (rank : 134)	NC score	0.020432 (rank : 304)
Query Neighborhood Hits	204	Target Neighborhood Hits	150	Shared Neighborhood Hits	19
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
θ value	0.813845 (rank : 135)	NC score	0.020430 (rank : 305)
Query Neighborhood Hits	204	Target Neighborhood Hits	150	Shared Neighborhood Hits	19
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

CF047_MOUSE
θ value	1.06291 (rank : 136)	NC score	0.023640 (rank : 296)
Query Neighborhood Hits	204	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z1R4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf47 homolog.

OXRP_HUMAN
θ value	1.06291 (rank : 137)	NC score	0.009128 (rank : 326)
Query Neighborhood Hits	204	Target Neighborhood Hits	544	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y4L1	Gene names	HYOU1, ORP150
Domain Architecture
Description	150 kDa oxygen-regulated protein precursor (Orp150) (Hypoxia up- regulated 1).

SSH2_MOUSE
θ value	1.06291 (rank : 138)	NC score	0.008689 (rank : 327)
Query Neighborhood Hits	204	Target Neighborhood Hits	119	Shared Neighborhood Hits	5
SwissProt Accessions	Q5SW75, Q3TDK8, Q3TYP8, Q3U2K3, Q5F268, Q5SW74, Q69ZC3, Q76I78	Gene names	Ssh2, Kiaa1725, Ssh2l
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-2L) (mSSH-2L).

NXF5_HUMAN
θ value	1.38821 (rank : 139)	NC score	0.020740 (rank : 302)
Query Neighborhood Hits	204	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H1B4, Q9H1B0, Q9H1B1, Q9H1B2, Q9H1B3	Gene names	NXF5, TAPL1
Domain Architecture	No domain graphic available
Description	Nuclear RNA export factor 5 (TAP-like protein 1) (TAPL-1).

PA24D_MOUSE
θ value	1.38821 (rank : 140)	NC score	0.027651 (rank : 291)
Query Neighborhood Hits	204	Target Neighborhood Hits	100	Shared Neighborhood Hits	18
SwissProt Accessions	Q50L43, Q3TJC5	Gene names	Pla2g4d
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

TAGAP_MOUSE
θ value	1.38821 (rank : 141)	NC score	0.549292 (rank : 48)
Query Neighborhood Hits	204	Target Neighborhood Hits	83	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

KPCA_HUMAN
θ value	1.81305 (rank : 142)	NC score	0.020827 (rank : 301)
Query Neighborhood Hits	204	Target Neighborhood Hits	1070	Shared Neighborhood Hits	39
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

MO4L2_HUMAN
θ value	1.81305 (rank : 143)	NC score	0.013288 (rank : 317)
Query Neighborhood Hits	204	Target Neighborhood Hits	90	Shared Neighborhood Hits	6
SwissProt Accessions	Q15014, Q567V0, Q8J026	Gene names	MORF4L2, KIAA0026, MRGX
Domain Architecture
Description	Mortality factor 4-like protein 2 (MORF-related gene X protein) (Transcription factor-like protein MRGX) (MSL3-2 protein).

NFH_MOUSE
θ value	1.81305 (rank : 144)	NC score	0.019722 (rank : 307)
Query Neighborhood Hits	204	Target Neighborhood Hits	2247	Shared Neighborhood Hits	58
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

UN13B_HUMAN
θ value	1.81305 (rank : 145)	NC score	0.084827 (rank : 183)
Query Neighborhood Hits	204	Target Neighborhood Hits	217	Shared Neighborhood Hits	34
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

B3A3_MOUSE
θ value	2.36792 (rank : 146)	NC score	0.009284 (rank : 325)
Query Neighborhood Hits	204	Target Neighborhood Hits	112	Shared Neighborhood Hits	11
SwissProt Accessions	P16283	Gene names	Slc4a3, Ae3
Domain Architecture
Description	Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3).

BSN_MOUSE
θ value	2.36792 (rank : 147)	NC score	0.037248 (rank : 284)
Query Neighborhood Hits	204	Target Neighborhood Hits	2057	Shared Neighborhood Hits	50
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CAC1F_HUMAN
θ value	2.36792 (rank : 148)	NC score	0.003252 (rank : 339)
Query Neighborhood Hits	204	Target Neighborhood Hits	141	Shared Neighborhood Hits	4
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

K0179_HUMAN
θ value	2.36792 (rank : 149)	NC score	0.015551 (rank : 314)
Query Neighborhood Hits	204	Target Neighborhood Hits	81	Shared Neighborhood Hits	6
SwissProt Accessions	Q14684, Q8TBZ4	Gene names	KIAA0179
Domain Architecture
Description	Protein KIAA0179.

NEURL_MOUSE
θ value	2.36792 (rank : 150)	NC score	0.016944 (rank : 312)
Query Neighborhood Hits	204	Target Neighborhood Hits	106	Shared Neighborhood Hits	5
SwissProt Accessions	Q923S6, Q91ZT6, Q9CWF1, Q9QWF1	Gene names	Neurl, Neurl1
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (m-neuralized 1) (m-neu1).

PCLO_HUMAN
θ value	2.36792 (rank : 151)	NC score	0.048940 (rank : 280)
Query Neighborhood Hits	204	Target Neighborhood Hits	2046	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PCLO_MOUSE
θ value	2.36792 (rank : 152)	NC score	0.042087 (rank : 283)
Query Neighborhood Hits	204	Target Neighborhood Hits	2275	Shared Neighborhood Hits	70
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PINK1_HUMAN
θ value	2.36792 (rank : 153)	NC score	0.003614 (rank : 338)
Query Neighborhood Hits	204	Target Neighborhood Hits	741	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

UN13B_MOUSE
θ value	2.36792 (rank : 154)	NC score	0.082719 (rank : 188)
Query Neighborhood Hits	204	Target Neighborhood Hits	210	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

ARHG2_HUMAN
θ value	3.0926 (rank : 155)	NC score	0.224847 (rank : 126)
Query Neighborhood Hits	204	Target Neighborhood Hits	142	Shared Neighborhood Hits	57
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

DHX57_HUMAN
θ value	3.0926 (rank : 156)	NC score	0.004360 (rank : 336)
Query Neighborhood Hits	204	Target Neighborhood Hits	109	Shared Neighborhood Hits	2
SwissProt Accessions	Q6P158, Q53SI4, Q6P9G1, Q7Z6H3, Q8NG17, Q96M33	Gene names	DHX57
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX57 (EC 3.6.1.-) (DEAH box protein 57).

FBX41_HUMAN
θ value	3.0926 (rank : 157)	NC score	0.008231 (rank : 328)
Query Neighborhood Hits	204	Target Neighborhood Hits	475	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TF61	Gene names	FBXO41, FBX41, KIAA1940
Domain Architecture	No domain graphic available
Description	F-box only protein 41.

JADE2_MOUSE
θ value	3.0926 (rank : 158)	NC score	0.020364 (rank : 306)
Query Neighborhood Hits	204	Target Neighborhood Hits	560	Shared Neighborhood Hits	23
SwissProt Accessions	Q6ZQF7, Q3UHD5, Q6IE83	Gene names	Phf15, Jade2, Kiaa0239
Domain Architecture	No domain graphic available
Description	Protein Jade-2 (PHD finger protein 15).

ARFG1_MOUSE
θ value	4.03905 (rank : 159)	NC score	0.048896 (rank : 281)
Query Neighborhood Hits	204	Target Neighborhood Hits	51	Shared Neighborhood Hits	8
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

CCD94_MOUSE
θ value	4.03905 (rank : 160)	NC score	0.028227 (rank : 290)
Query Neighborhood Hits	204	Target Neighborhood Hits	127	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D6J3	Gene names	Ccdc94
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 94.

CT2NL_HUMAN
θ value	4.03905 (rank : 161)	NC score	0.022759 (rank : 298)
Query Neighborhood Hits	204	Target Neighborhood Hits	1059	Shared Neighborhood Hits	27
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

HXC11_HUMAN
θ value	4.03905 (rank : 162)	NC score	-0.001563 (rank : 348)
Query Neighborhood Hits	204	Target Neighborhood Hits	349	Shared Neighborhood Hits	4
SwissProt Accessions	O43248, Q96DH2	Gene names	HOXC11
Domain Architecture
Description	Homeobox protein Hox-C11.

LRSM1_HUMAN
θ value	4.03905 (rank : 163)	NC score	0.012605 (rank : 318)
Query Neighborhood Hits	204	Target Neighborhood Hits	1078	Shared Neighborhood Hits	28
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

PA24F_HUMAN
θ value	4.03905 (rank : 164)	NC score	0.016208 (rank : 313)
Query Neighborhood Hits	204	Target Neighborhood Hits	78	Shared Neighborhood Hits	15
SwissProt Accessions	Q68DD2, Q6ZMC8	Gene names	PLA2G4F
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

PPIP1_HUMAN
θ value	4.03905 (rank : 165)	NC score	0.085714 (rank : 180)
Query Neighborhood Hits	204	Target Neighborhood Hits	389	Shared Neighborhood Hits	35
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PRC1_HUMAN
θ value	4.03905 (rank : 166)	NC score	0.015029 (rank : 315)
Query Neighborhood Hits	204	Target Neighborhood Hits	328	Shared Neighborhood Hits	11
SwissProt Accessions	O43663, Q9BSB6	Gene names	PRC1
Domain Architecture	No domain graphic available
Description	Protein regulator of cytokinesis 1.

SOX13_MOUSE
θ value	4.03905 (rank : 167)	NC score	0.017926 (rank : 311)
Query Neighborhood Hits	204	Target Neighborhood Hits	495	Shared Neighborhood Hits	21
SwissProt Accessions	Q04891, Q922L3	Gene names	Sox13, Sox-13
Domain Architecture
Description	SOX-13 protein.

TCF8_MOUSE
θ value	4.03905 (rank : 168)	NC score	-0.005368 (rank : 351)
Query Neighborhood Hits	204	Target Neighborhood Hits	1067	Shared Neighborhood Hits	23
SwissProt Accessions	Q64318, Q62519	Gene names	Tcf8, Zfhx1a, Zfx1a, Zfx1ha
Domain Architecture
Description	Transcription factor 8 (Zinc finger homeobox protein 1a) (MEB1) (Delta EF1).

ANK2_HUMAN
θ value	5.27518 (rank : 169)	NC score	0.006367 (rank : 334)
Query Neighborhood Hits	204	Target Neighborhood Hits	1615	Shared Neighborhood Hits	45
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

B3A3_HUMAN
θ value	5.27518 (rank : 170)	NC score	0.007752 (rank : 330)
Query Neighborhood Hits	204	Target Neighborhood Hits	119	Shared Neighborhood Hits	10
SwissProt Accessions	P48751	Gene names	SLC4A3, AE3
Domain Architecture
Description	Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3).

BAT2_HUMAN
θ value	5.27518 (rank : 171)	NC score	0.035792 (rank : 285)
Query Neighborhood Hits	204	Target Neighborhood Hits	931	Shared Neighborhood Hits	37
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

BAT2_MOUSE
θ value	5.27518 (rank : 172)	NC score	0.032772 (rank : 288)
Query Neighborhood Hits	204	Target Neighborhood Hits	947	Shared Neighborhood Hits	37
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

FOG1_MOUSE
θ value	5.27518 (rank : 173)	NC score	-0.000747 (rank : 347)
Query Neighborhood Hits	204	Target Neighborhood Hits	1237	Shared Neighborhood Hits	31
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

NEUL1_HUMAN
θ value	5.27518 (rank : 174)	NC score	0.014718 (rank : 316)
Query Neighborhood Hits	204	Target Neighborhood Hits	114	Shared Neighborhood Hits	6
SwissProt Accessions	O76050, Q5TDR2, Q5TDR3, Q8TAN0, Q9H463	Gene names	NEURL, NEURL1, RNF67
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (h-neuralized 1) (h-neu) (RING finger protein 67).

NTKL_HUMAN
θ value	5.27518 (rank : 175)	NC score	0.011116 (rank : 321)
Query Neighborhood Hits	204	Target Neighborhood Hits	266	Shared Neighborhood Hits	10
SwissProt Accessions	Q96KG9, Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53	Gene names	SCYL1, GKLP, NTKL, TAPK, TEIF, TRAP
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (Teratoma- associated tyrosine kinase) (Telomerase transcriptional element- interacting factor) (Telomerase regulation-associated protein).

NTKL_MOUSE
θ value	5.27518 (rank : 176)	NC score	0.009312 (rank : 324)
Query Neighborhood Hits	204	Target Neighborhood Hits	326	Shared Neighborhood Hits	9
SwissProt Accessions	Q9EQC5, Q3TST7, Q3UKU0, Q8K222	Gene names	Scyl1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (105 kDa kinase- like protein) (Mitosis-associated kinase-like protein NTKL).

PITM1_HUMAN
θ value	5.27518 (rank : 177)	NC score	0.005688 (rank : 335)
Query Neighborhood Hits	204	Target Neighborhood Hits	129	Shared Neighborhood Hits	8
SwissProt Accessions	O00562, Q6T7X3, Q8TBN3, Q9BZ73	Gene names	PITPNM1, DRES9, NIR2, PITPNM
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 1 (Phosphatidylinositol transfer protein, membrane-associated 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) (Drosophila retinal degeneration B homolog).

UN13A_HUMAN
θ value	5.27518 (rank : 178)	NC score	0.087349 (rank : 177)
Query Neighborhood Hits	204	Target Neighborhood Hits	285	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

BSN_HUMAN
θ value	6.88961 (rank : 179)	NC score	0.032226 (rank : 289)
Query Neighborhood Hits	204	Target Neighborhood Hits	1537	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

DDFL1_MOUSE
θ value	6.88961 (rank : 180)	NC score	0.048965 (rank : 279)
Query Neighborhood Hits	204	Target Neighborhood Hits	324	Shared Neighborhood Hits	15
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

HSN2_MOUSE
θ value	6.88961 (rank : 181)	NC score	0.010939 (rank : 322)
Query Neighborhood Hits	204	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q6IFS6	Gene names	Hsn2
Domain Architecture	No domain graphic available
Description	Protein HSN2 precursor.

K0528_MOUSE
θ value	6.88961 (rank : 182)	NC score	0.035383 (rank : 286)
Query Neighborhood Hits	204	Target Neighborhood Hits	102	Shared Neighborhood Hits	18
SwissProt Accessions	Q7TPS5, Q3TQY6, Q6A052, Q80VA1, Q8C0U3, Q8CID5, Q9CS85	Gene names	Kiaa0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

KPCA_MOUSE
θ value	6.88961 (rank : 183)	NC score	0.018835 (rank : 310)
Query Neighborhood Hits	204	Target Neighborhood Hits	1067	Shared Neighborhood Hits	39
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

MK04_MOUSE
θ value	6.88961 (rank : 184)	NC score	-0.004669 (rank : 350)
Query Neighborhood Hits	204	Target Neighborhood Hits	852	Shared Neighborhood Hits	10
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

TBX2_HUMAN
θ value	6.88961 (rank : 185)	NC score	0.002883 (rank : 341)
Query Neighborhood Hits	204	Target Neighborhood Hits	195	Shared Neighborhood Hits	9
SwissProt Accessions	Q13207, Q16424, Q7Z647	Gene names	TBX2
Domain Architecture
Description	T-box transcription factor TBX2 (T-box protein 2).

ZN263_HUMAN
θ value	6.88961 (rank : 186)	NC score	-0.006993 (rank : 352)
Query Neighborhood Hits	204	Target Neighborhood Hits	795	Shared Neighborhood Hits	11
SwissProt Accessions	O14978, O43387, Q96H95	Gene names	ZNF263, FPM315
Domain Architecture
Description	Zinc finger protein 263 (Zinc finger protein FPM315).

ADIP_MOUSE
θ value	8.99809 (rank : 187)	NC score	0.007810 (rank : 329)
Query Neighborhood Hits	204	Target Neighborhood Hits	415	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VC66, Q8BG59, Q8C7X0, Q8K2F7	Gene names	Ssx2ip
Domain Architecture	No domain graphic available
Description	Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain- interacting protein).

BAG3_MOUSE
θ value	8.99809 (rank : 188)	NC score	0.019281 (rank : 308)
Query Neighborhood Hits	204	Target Neighborhood Hits	513	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

CABYR_MOUSE
θ value	8.99809 (rank : 189)	NC score	0.007283 (rank : 332)
Query Neighborhood Hits	204	Target Neighborhood Hits	80	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D424, Q91Y41, Q91Y42	Gene names	Cabyr, Cbp86
Domain Architecture	No domain graphic available
Description	Calcium-binding tyrosine phosphorylation-regulated protein (Calcium- binding protein 86) (Testis-specific calcium-binding protein CBP86).

CIC_HUMAN
θ value	8.99809 (rank : 190)	NC score	0.025320 (rank : 295)
Query Neighborhood Hits	204	Target Neighborhood Hits	992	Shared Neighborhood Hits	37
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

DYH5_HUMAN
θ value	8.99809 (rank : 191)	NC score	0.003854 (rank : 337)
Query Neighborhood Hits	204	Target Neighborhood Hits	323	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TE73, Q92860, Q96L74, Q9H5S7, Q9HCG9	Gene names	DNAH5, DNAHC5, KIAA1603
Domain Architecture	No domain graphic available
Description	Ciliary dynein heavy chain 5 (Axonemal beta dynein heavy chain 5) (HL1).

DYSF_HUMAN
θ value	8.99809 (rank : 192)	NC score	0.022316 (rank : 300)
Query Neighborhood Hits	204	Target Neighborhood Hits	170	Shared Neighborhood Hits	20
SwissProt Accessions	O75923, O75696, Q9UEN7	Gene names	DYSF, FER1L1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

DYSF_MOUSE
θ value	8.99809 (rank : 193)	NC score	0.020659 (rank : 303)
Query Neighborhood Hits	204	Target Neighborhood Hits	162	Shared Neighborhood Hits	20
SwissProt Accessions	Q9ESD7, Q9QXC0	Gene names	Dysf, Fer1l1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

K0528_HUMAN
θ value	8.99809 (rank : 194)	NC score	0.034800 (rank : 287)
Query Neighborhood Hits	204	Target Neighborhood Hits	96	Shared Neighborhood Hits	18
SwissProt Accessions	Q86YS7, O60280, Q7Z619, Q86SU3	Gene names	KIAA0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

MICA3_HUMAN
θ value	8.99809 (rank : 195)	NC score	0.000705 (rank : 344)
Query Neighborhood Hits	204	Target Neighborhood Hits	160	Shared Neighborhood Hits	4
SwissProt Accessions	Q7RTP6, Q6ICK4, Q9P2I3	Gene names	MICAL3, KIAA1364
Domain Architecture
Description	Protein MICAL-3.

NOS3_MOUSE
θ value	8.99809 (rank : 196)	NC score	0.003155 (rank : 340)
Query Neighborhood Hits	204	Target Neighborhood Hits	63	Shared Neighborhood Hits	5
SwissProt Accessions	P70313, O55056	Gene names	Nos3, Ecnos
Domain Architecture
Description	Nitric-oxide synthase, endothelial (EC 1.14.13.39) (EC-NOS) (NOS type III) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS).

NUCL_MOUSE
θ value	8.99809 (rank : 197)	NC score	0.000527 (rank : 345)
Query Neighborhood Hits	204	Target Neighborhood Hits	425	Shared Neighborhood Hits	8
SwissProt Accessions	P09405, Q548M9, Q61991, Q99K50	Gene names	Ncl, Nuc
Domain Architecture
Description	Nucleolin (Protein C23).

PZRN3_MOUSE
θ value	8.99809 (rank : 198)	NC score	-0.000264 (rank : 346)
Query Neighborhood Hits	204	Target Neighborhood Hits	447	Shared Neighborhood Hits	7
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

REXO4_MOUSE
θ value	8.99809 (rank : 199)	NC score	0.007689 (rank : 331)
Query Neighborhood Hits	204	Target Neighborhood Hits	42	Shared Neighborhood Hits	6
SwissProt Accessions	Q6PAQ4, Q3UU17, Q8C524	Gene names	Rexo4, Gm111, Pmc2, Xpmc2h
Domain Architecture	No domain graphic available
Description	RNA exonuclease 4 (EC 3.1.-.-) (Exonuclease XPMC2) (Prevents mitotic catastrophe 2 protein homolog).

RN168_HUMAN
θ value	8.99809 (rank : 200)	NC score	0.002793 (rank : 342)
Query Neighborhood Hits	204	Target Neighborhood Hits	370	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IYW5, Q8NA67, Q96NS4	Gene names	RNF168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

SRCH_HUMAN
θ value	8.99809 (rank : 201)	NC score	0.010713 (rank : 323)
Query Neighborhood Hits	204	Target Neighborhood Hits	225	Shared Neighborhood Hits	9
SwissProt Accessions	P23327, Q504Y6	Gene names	HRC, HCP
Domain Architecture	No domain graphic available
Description	Sarcoplasmic reticulum histidine-rich calcium-binding protein precursor.

YTDC1_HUMAN
θ value	8.99809 (rank : 202)	NC score	0.006433 (rank : 333)
Query Neighborhood Hits	204	Target Neighborhood Hits	458	Shared Neighborhood Hits	9
SwissProt Accessions	Q96MU7, Q7Z622, Q8TF35	Gene names	YTHDC1, KIAA1966, YT521
Domain Architecture
Description	YTH domain-containing protein 1 (Putative splicing factor YT521).

ZN445_HUMAN
θ value	8.99809 (rank : 203)	NC score	-0.007513 (rank : 353)
Query Neighborhood Hits	204	Target Neighborhood Hits	764	Shared Neighborhood Hits	7
SwissProt Accessions	P59923	Gene names	ZNF445, ZNF168
Domain Architecture
Description	Zinc finger protein 445.

ZO1_HUMAN
θ value	8.99809 (rank : 204)	NC score	0.001662 (rank : 343)
Query Neighborhood Hits	204	Target Neighborhood Hits	474	Shared Neighborhood Hits	12
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ABI1_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.081038 (rank : 190)
Query Neighborhood Hits	204	Target Neighborhood Hits	257	Shared Neighborhood Hits	34
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 206)	NC score	0.087263 (rank : 178)
Query Neighborhood Hits	204	Target Neighborhood Hits	246	Shared Neighborhood Hits	32
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.095588 (rank : 167)
Query Neighborhood Hits	204	Target Neighborhood Hits	350	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.095351 (rank : 168)
Query Neighborhood Hits	204	Target Neighborhood Hits	266	Shared Neighborhood Hits	32
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.069677 (rank : 215)
Query Neighborhood Hits	204	Target Neighborhood Hits	227	Shared Neighborhood Hits	36
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 210)	NC score	0.067459 (rank : 223)
Query Neighborhood Hits	204	Target Neighborhood Hits	227	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AHI1_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.065334 (rank : 228)
Query Neighborhood Hits	204	Target Neighborhood Hits	537	Shared Neighborhood Hits	37
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 212)	NC score	0.064452 (rank : 231)
Query Neighborhood Hits	204	Target Neighborhood Hits	496	Shared Neighborhood Hits	37
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ANM2_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.068749 (rank : 217)
Query Neighborhood Hits	204	Target Neighborhood Hits	175	Shared Neighborhood Hits	24
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 214)	NC score	0.068588 (rank : 219)
Query Neighborhood Hits	204	Target Neighborhood Hits	175	Shared Neighborhood Hits	24
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHG2_MOUSE
θ value	θ > 10 (rank : 215)	NC score	0.246350 (rank : 125)
Query Neighborhood Hits	204	Target Neighborhood Hits	120	Shared Neighborhood Hits	60
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHGC_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.222041 (rank : 128)
Query Neighborhood Hits	204	Target Neighborhood Hits	351	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 217)	NC score	0.220514 (rank : 129)
Query Neighborhood Hits	204	Target Neighborhood Hits	344	Shared Neighborhood Hits	60
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

BCAR1_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.056567 (rank : 251)
Query Neighborhood Hits	204	Target Neighborhood Hits	554	Shared Neighborhood Hits	40
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	θ > 10 (rank : 219)	NC score	0.065404 (rank : 227)
Query Neighborhood Hits	204	Target Neighborhood Hits	438	Shared Neighborhood Hits	43
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BI2L1_HUMAN
θ value	θ > 10 (rank : 220)	NC score	0.054732 (rank : 260)
Query Neighborhood Hits	204	Target Neighborhood Hits	156	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CD2AP_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.119070 (rank : 146)
Query Neighborhood Hits	204	Target Neighborhood Hits	315	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.113518 (rank : 149)
Query Neighborhood Hits	204	Target Neighborhood Hits	336	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CENA1_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.057096 (rank : 248)
Query Neighborhood Hits	204	Target Neighborhood Hits	87	Shared Neighborhood Hits	15
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

CENA2_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.053969 (rank : 264)
Query Neighborhood Hits	204	Target Neighborhood Hits	83	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

CENB1_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.070971 (rank : 212)
Query Neighborhood Hits	204	Target Neighborhood Hits	383	Shared Neighborhood Hits	20
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

CENB2_HUMAN
θ value	θ > 10 (rank : 226)	NC score	0.078688 (rank : 193)
Query Neighborhood Hits	204	Target Neighborhood Hits	425	Shared Neighborhood Hits	21
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENB5_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.074344 (rank : 204)
Query Neighborhood Hits	204	Target Neighborhood Hits	395	Shared Neighborhood Hits	21
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CIP4_HUMAN
θ value	θ > 10 (rank : 228)	NC score	0.062005 (rank : 236)
Query Neighborhood Hits	204	Target Neighborhood Hits	374	Shared Neighborhood Hits	17
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CRKL_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.091256 (rank : 173)
Query Neighborhood Hits	204	Target Neighborhood Hits	313	Shared Neighborhood Hits	34
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 230)	NC score	0.085026 (rank : 181)
Query Neighborhood Hits	204	Target Neighborhood Hits	307	Shared Neighborhood Hits	33
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.075988 (rank : 199)
Query Neighborhood Hits	204	Target Neighborhood Hits	308	Shared Neighborhood Hits	30
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 232)	NC score	0.077171 (rank : 196)
Query Neighborhood Hits	204	Target Neighborhood Hits	314	Shared Neighborhood Hits	31
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CT032_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.052190 (rank : 267)
Query Neighborhood Hits	204	Target Neighborhood Hits	235	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DAPP1_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.063547 (rank : 232)
Query Neighborhood Hits	204	Target Neighborhood Hits	227	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 235)	NC score	0.065203 (rank : 229)
Query Neighborhood Hits	204	Target Neighborhood Hits	225	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DBNL_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.050079 (rank : 278)
Query Neighborhood Hits	204	Target Neighborhood Hits	244	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DDEF1_MOUSE
θ value	θ > 10 (rank : 237)	NC score	0.079264 (rank : 192)
Query Neighborhood Hits	204	Target Neighborhood Hits	592	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.085010 (rank : 182)
Query Neighborhood Hits	204	Target Neighborhood Hits	599	Shared Neighborhood Hits	51
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	θ > 10 (rank : 239)	NC score	0.083833 (rank : 186)
Query Neighborhood Hits	204	Target Neighborhood Hits	625	Shared Neighborhood Hits	46
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDFL1_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.052493 (rank : 266)
Query Neighborhood Hits	204	Target Neighborhood Hits	353	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

DGKH_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.062427 (rank : 234)
Query Neighborhood Hits	204	Target Neighborhood Hits	255	Shared Neighborhood Hits	34
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

EFS_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.055852 (rank : 254)
Query Neighborhood Hits	204	Target Neighborhood Hits	348	Shared Neighborhood Hits	38
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	θ > 10 (rank : 243)	NC score	0.059031 (rank : 244)
Query Neighborhood Hits	204	Target Neighborhood Hits	389	Shared Neighborhood Hits	42
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

FYV1_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.060426 (rank : 239)
Query Neighborhood Hits	204	Target Neighborhood Hits	217	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	θ > 10 (rank : 245)	NC score	0.059977 (rank : 241)
Query Neighborhood Hits	204	Target Neighborhood Hits	191	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

GRAP2_HUMAN
θ value	θ > 10 (rank : 246)	NC score	0.092262 (rank : 170)
Query Neighborhood Hits	204	Target Neighborhood Hits	304	Shared Neighborhood Hits	35
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 247)	NC score	0.090353 (rank : 175)
Query Neighborhood Hits	204	Target Neighborhood Hits	297	Shared Neighborhood Hits	33
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.112468 (rank : 151)
Query Neighborhood Hits	204	Target Neighborhood Hits	307	Shared Neighborhood Hits	36
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 249)	NC score	0.108695 (rank : 157)
Query Neighborhood Hits	204	Target Neighborhood Hits	309	Shared Neighborhood Hits	37
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.106205 (rank : 160)
Query Neighborhood Hits	204	Target Neighborhood Hits	310	Shared Neighborhood Hits	34
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 251)	NC score	0.106178 (rank : 161)
Query Neighborhood Hits	204	Target Neighborhood Hits	312	Shared Neighborhood Hits	34
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRP3_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.119576 (rank : 144)
Query Neighborhood Hits	204	Target Neighborhood Hits	131	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

HCLS1_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.097508 (rank : 165)
Query Neighborhood Hits	204	Target Neighborhood Hits	358	Shared Neighborhood Hits	36
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 254)	NC score	0.097837 (rank : 164)
Query Neighborhood Hits	204	Target Neighborhood Hits	329	Shared Neighborhood Hits	36
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HGS_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.068074 (rank : 221)
Query Neighborhood Hits	204	Target Neighborhood Hits	517	Shared Neighborhood Hits	30
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	θ > 10 (rank : 256)	NC score	0.070286 (rank : 213)
Query Neighborhood Hits	204	Target Neighborhood Hits	589	Shared Neighborhood Hits	31
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

IASPP_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.054415 (rank : 262)
Query Neighborhood Hits	204	Target Neighborhood Hits	688	Shared Neighborhood Hits	41
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IASPP_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.056973 (rank : 249)
Query Neighborhood Hits	204	Target Neighborhood Hits	1024	Shared Neighborhood Hits	51
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

LBC_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.222105 (rank : 127)
Query Neighborhood Hits	204	Target Neighborhood Hits	90	Shared Neighborhood Hits	47
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

MYO1E_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.060188 (rank : 240)
Query Neighborhood Hits	204	Target Neighborhood Hits	293	Shared Neighborhood Hits	37
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

MYO1F_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.061876 (rank : 237)
Query Neighborhood Hits	204	Target Neighborhood Hits	275	Shared Neighborhood Hits	33
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.062192 (rank : 235)
Query Neighborhood Hits	204	Target Neighborhood Hits	262	Shared Neighborhood Hits	31
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

NCF1_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.092966 (rank : 169)
Query Neighborhood Hits	204	Target Neighborhood Hits	198	Shared Neighborhood Hits	28
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 264)	NC score	0.096084 (rank : 166)
Query Neighborhood Hits	204	Target Neighborhood Hits	198	Shared Neighborhood Hits	30
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.111011 (rank : 153)
Query Neighborhood Hits	204	Target Neighborhood Hits	229	Shared Neighborhood Hits	37
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.106339 (rank : 159)
Query Neighborhood Hits	204	Target Neighborhood Hits	161	Shared Neighborhood Hits	23
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.109937 (rank : 156)
Query Neighborhood Hits	204	Target Neighborhood Hits	177	Shared Neighborhood Hits	27
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.110992 (rank : 154)
Query Neighborhood Hits	204	Target Neighborhood Hits	312	Shared Neighborhood Hits	37
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.123521 (rank : 140)
Query Neighborhood Hits	204	Target Neighborhood Hits	310	Shared Neighborhood Hits	43
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NOXO1_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.059711 (rank : 243)
Query Neighborhood Hits	204	Target Neighborhood Hits	100	Shared Neighborhood Hits	20
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.065056 (rank : 230)
Query Neighborhood Hits	204	Target Neighborhood Hits	114	Shared Neighborhood Hits	20
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.070998 (rank : 211)
Query Neighborhood Hits	204	Target Neighborhood Hits	288	Shared Neighborhood Hits	27
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.076046 (rank : 198)
Query Neighborhood Hits	204	Target Neighborhood Hits	267	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OSTF1_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.069905 (rank : 214)
Query Neighborhood Hits	204	Target Neighborhood Hits	466	Shared Neighborhood Hits	29
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.068490 (rank : 220)
Query Neighborhood Hits	204	Target Neighborhood Hits	467	Shared Neighborhood Hits	30
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

P55G_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.072584 (rank : 206)
Query Neighborhood Hits	204	Target Neighborhood Hits	451	Shared Neighborhood Hits	16
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.071865 (rank : 208)
Query Neighborhood Hits	204	Target Neighborhood Hits	401	Shared Neighborhood Hits	15
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

PACN1_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.055918 (rank : 253)
Query Neighborhood Hits	204	Target Neighborhood Hits	320	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.056581 (rank : 250)
Query Neighborhood Hits	204	Target Neighborhood Hits	283	Shared Neighborhood Hits	29
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.060943 (rank : 238)
Query Neighborhood Hits	204	Target Neighborhood Hits	339	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 281)	NC score	0.057996 (rank : 247)
Query Neighborhood Hits	204	Target Neighborhood Hits	382	Shared Neighborhood Hits	34
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.052153 (rank : 268)
Query Neighborhood Hits	204	Target Neighborhood Hits	385	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.054865 (rank : 259)
Query Neighborhood Hits	204	Target Neighborhood Hits	380	Shared Neighborhood Hits	30
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PCTL_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.055172 (rank : 256)
Query Neighborhood Hits	204	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y365, O60532	Gene names	STARD10, SDCCAG28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28) (Antigen NY-CO-28).

PCTL_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.055798 (rank : 255)
Query Neighborhood Hits	204	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JMD3	Gene names	Stard10, Pctpl, Sdccag28, Sdccagg28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28 homolog).

PDZD8_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.058461 (rank : 245)
Query Neighborhood Hits	204	Target Neighborhood Hits	185	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PEX13_HUMAN
θ value	θ > 10 (rank : 287)	NC score	0.050640 (rank : 276)
Query Neighborhood Hits	204	Target Neighborhood Hits	128	Shared Neighborhood Hits	23
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 288)	NC score	0.051479 (rank : 272)
Query Neighborhood Hits	204	Target Neighborhood Hits	126	Shared Neighborhood Hits	21
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PKHA1_HUMAN
θ value	θ > 10 (rank : 289)	NC score	0.056555 (rank : 252)
Query Neighborhood Hits	204	Target Neighborhood Hits	127	Shared Neighborhood Hits	19
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	θ > 10 (rank : 290)	NC score	0.050159 (rank : 277)
Query Neighborhood Hits	204	Target Neighborhood Hits	120	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.050998 (rank : 275)
Query Neighborhood Hits	204	Target Neighborhood Hits	116	Shared Neighborhood Hits	17
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA4_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.066950 (rank : 224)
Query Neighborhood Hits	204	Target Neighborhood Hits	283	Shared Neighborhood Hits	33
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.069240 (rank : 216)
Query Neighborhood Hits	204	Target Neighborhood Hits	202	Shared Neighborhood Hits	24
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA5_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.055170 (rank : 257)
Query Neighborhood Hits	204	Target Neighborhood Hits	455	Shared Neighborhood Hits	25
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA6_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.088565 (rank : 176)
Query Neighborhood Hits	204	Target Neighborhood Hits	556	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	θ > 10 (rank : 296)	NC score	0.091293 (rank : 172)
Query Neighborhood Hits	204	Target Neighborhood Hits	591	Shared Neighborhood Hits	35
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHF1_HUMAN
θ value	θ > 10 (rank : 297)	NC score	0.140100 (rank : 136)
Query Neighborhood Hits	204	Target Neighborhood Hits	76	Shared Neighborhood Hits	18
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
θ value	θ > 10 (rank : 298)	NC score	0.141593 (rank : 134)
Query Neighborhood Hits	204	Target Neighborhood Hits	80	Shared Neighborhood Hits	21
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF2_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.145049 (rank : 132)
Query Neighborhood Hits	204	Target Neighborhood Hits	75	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	θ > 10 (rank : 300)	NC score	0.144674 (rank : 133)
Query Neighborhood Hits	204	Target Neighborhood Hits	77	Shared Neighborhood Hits	19
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PLCG1_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.065763 (rank : 226)
Query Neighborhood Hits	204	Target Neighborhood Hits	293	Shared Neighborhood Hits	39
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 302)	NC score	0.066454 (rank : 225)
Query Neighborhood Hits	204	Target Neighborhood Hits	314	Shared Neighborhood Hits	38
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.059944 (rank : 242)
Query Neighborhood Hits	204	Target Neighborhood Hits	280	Shared Neighborhood Hits	31
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP1_MOUSE
θ value	θ > 10 (rank : 304)	NC score	0.076634 (rank : 197)
Query Neighborhood Hits	204	Target Neighborhood Hits	377	Shared Neighborhood Hits	36
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

RBNS5_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.068641 (rank : 218)
Query Neighborhood Hits	204	Target Neighborhood Hits	242	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	θ > 10 (rank : 306)	NC score	0.063061 (rank : 233)
Query Neighborhood Hits	204	Target Neighborhood Hits	266	Shared Neighborhood Hits	14
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

RGNEF_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.209077 (rank : 130)
Query Neighborhood Hits	204	Target Neighborhood Hits	641	Shared Neighborhood Hits	67
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RUFY2_MOUSE
θ value	θ > 10 (rank : 308)	NC score	0.055067 (rank : 258)
Query Neighborhood Hits	204	Target Neighborhood Hits	820	Shared Neighborhood Hits	29
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

RUSC1_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.051108 (rank : 273)
Query Neighborhood Hits	204	Target Neighborhood Hits	206	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

SH3G1_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.075270 (rank : 201)
Query Neighborhood Hits	204	Target Neighborhood Hits	307	Shared Neighborhood Hits	32
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.072028 (rank : 207)
Query Neighborhood Hits	204	Target Neighborhood Hits	291	Shared Neighborhood Hits	29
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.074220 (rank : 205)
Query Neighborhood Hits	204	Target Neighborhood Hits	324	Shared Neighborhood Hits	31
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 313)	NC score	0.074470 (rank : 203)
Query Neighborhood Hits	204	Target Neighborhood Hits	319	Shared Neighborhood Hits	30
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.071176 (rank : 209)
Query Neighborhood Hits	204	Target Neighborhood Hits	222	Shared Neighborhood Hits	29
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 315)	NC score	0.071141 (rank : 210)
Query Neighborhood Hits	204	Target Neighborhood Hits	236	Shared Neighborhood Hits	29
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.123914 (rank : 139)
Query Neighborhood Hits	204	Target Neighborhood Hits	341	Shared Neighborhood Hits	38
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 317)	NC score	0.121155 (rank : 141)
Query Neighborhood Hits	204	Target Neighborhood Hits	332	Shared Neighborhood Hits	37
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SOS1_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.149216 (rank : 131)
Query Neighborhood Hits	204	Target Neighborhood Hits	274	Shared Neighborhood Hits	43
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	θ > 10 (rank : 319)	NC score	0.141167 (rank : 135)
Query Neighborhood Hits	204	Target Neighborhood Hits	281	Shared Neighborhood Hits	43
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS2_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.132282 (rank : 138)
Query Neighborhood Hits	204	Target Neighborhood Hits	193	Shared Neighborhood Hits	40
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SPTA1_MOUSE
θ value	θ > 10 (rank : 321)	NC score	0.052085 (rank : 269)
Query Neighborhood Hits	204	Target Neighborhood Hits	675	Shared Neighborhood Hits	44
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.054101 (rank : 263)
Query Neighborhood Hits	204	Target Neighborhood Hits	888	Shared Neighborhood Hits	40
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SRBS1_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.118113 (rank : 147)
Query Neighborhood Hits	204	Target Neighborhood Hits	396	Shared Neighborhood Hits	47
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 324)	NC score	0.120179 (rank : 142)
Query Neighborhood Hits	204	Target Neighborhood Hits	409	Shared Neighborhood Hits	47
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.081019 (rank : 191)
Query Neighborhood Hits	204	Target Neighborhood Hits	269	Shared Neighborhood Hits	31
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 326)	NC score	0.083190 (rank : 187)
Query Neighborhood Hits	204	Target Neighborhood Hits	292	Shared Neighborhood Hits	31
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

STAC3_HUMAN
θ value	θ > 10 (rank : 327)	NC score	0.108523 (rank : 158)
Query Neighborhood Hits	204	Target Neighborhood Hits	228	Shared Neighborhood Hits	36
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 328)	NC score	0.110415 (rank : 155)
Query Neighborhood Hits	204	Target Neighborhood Hits	232	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 329)	NC score	0.099988 (rank : 163)
Query Neighborhood Hits	204	Target Neighborhood Hits	276	Shared Neighborhood Hits	36
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 330)	NC score	0.102902 (rank : 162)
Query Neighborhood Hits	204	Target Neighborhood Hits	268	Shared Neighborhood Hits	36
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 331)	NC score	0.077512 (rank : 195)
Query Neighborhood Hits	204	Target Neighborhood Hits	271	Shared Neighborhood Hits	30
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 332)	NC score	0.077745 (rank : 194)
Query Neighborhood Hits	204	Target Neighborhood Hits	273	Shared Neighborhood Hits	29
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 333)	NC score	0.074994 (rank : 202)
Query Neighborhood Hits	204	Target Neighborhood Hits	288	Shared Neighborhood Hits	30
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 334)	NC score	0.075294 (rank : 200)
Query Neighborhood Hits	204	Target Neighborhood Hits	285	Shared Neighborhood Hits	30
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

TCRG1_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.051070 (rank : 274)
Query Neighborhood Hits	204	Target Neighborhood Hits	929	Shared Neighborhood Hits	26
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

TCRG1_MOUSE
θ value	θ > 10 (rank : 336)	NC score	0.051891 (rank : 271)
Query Neighborhood Hits	204	Target Neighborhood Hits	947	Shared Neighborhood Hits	29
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

TIAM1_HUMAN
θ value	θ > 10 (rank : 337)	NC score	0.323878 (rank : 96)
Query Neighborhood Hits	204	Target Neighborhood Hits	225	Shared Neighborhood Hits	71
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 338)	NC score	0.323962 (rank : 95)
Query Neighborhood Hits	204	Target Neighborhood Hits	205	Shared Neighborhood Hits	67
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

VAV2_HUMAN
θ value	θ > 10 (rank : 339)	NC score	0.268435 (rank : 119)
Query Neighborhood Hits	204	Target Neighborhood Hits	453	Shared Neighborhood Hits	80
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	θ > 10 (rank : 340)	NC score	0.269759 (rank : 117)
Query Neighborhood Hits	204	Target Neighborhood Hits	456	Shared Neighborhood Hits	81
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.265210 (rank : 121)
Query Neighborhood Hits	204	Target Neighborhood Hits	452	Shared Neighborhood Hits	86
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VINEX_HUMAN
θ value	θ > 10 (rank : 342)	NC score	0.117152 (rank : 148)
Query Neighborhood Hits	204	Target Neighborhood Hits	270	Shared Neighborhood Hits	43
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 343)	NC score	0.119448 (rank : 145)
Query Neighborhood Hits	204	Target Neighborhood Hits	286	Shared Neighborhood Hits	41
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ZFY16_HUMAN
θ value	θ > 10 (rank : 344)	NC score	0.084035 (rank : 184)
Query Neighborhood Hits	204	Target Neighborhood Hits	125	Shared Neighborhood Hits	12
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY16_MOUSE
θ value	θ > 10 (rank : 345)	NC score	0.087065 (rank : 179)
Query Neighborhood Hits	204	Target Neighborhood Hits	108	Shared Neighborhood Hits	14
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY19_HUMAN
θ value	θ > 10 (rank : 346)	NC score	0.058136 (rank : 246)
Query Neighborhood Hits	204	Target Neighborhood Hits	206	Shared Neighborhood Hits	12
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ZFY19_MOUSE
θ value	θ > 10 (rank : 347)	NC score	0.054543 (rank : 261)
Query Neighborhood Hits	204	Target Neighborhood Hits	143	Shared Neighborhood Hits	13
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

ZFY21_HUMAN
θ value	θ > 10 (rank : 348)	NC score	0.081932 (rank : 189)
Query Neighborhood Hits	204	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_MOUSE
θ value	θ > 10 (rank : 349)	NC score	0.083846 (rank : 185)
Query Neighborhood Hits	204	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY28_HUMAN
θ value	θ > 10 (rank : 350)	NC score	0.091623 (rank : 171)
Query Neighborhood Hits	204	Target Neighborhood Hits	152	Shared Neighborhood Hits	14
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV1_HUMAN
θ value	θ > 10 (rank : 351)	NC score	0.053019 (rank : 265)
Query Neighborhood Hits	204	Target Neighborhood Hits	166	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
θ value	θ > 10 (rank : 352)	NC score	0.051914 (rank : 270)
Query Neighborhood Hits	204	Target Neighborhood Hits	153	Shared Neighborhood Hits	12
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

ZFYV9_HUMAN
θ value	θ > 10 (rank : 353)	NC score	0.090603 (rank : 174)
Query Neighborhood Hits	204	Target Neighborhood Hits	134	Shared Neighborhood Hits	13
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

Hits sorted by NC score

BCR_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	204	Target Neighborhood Hits	204	Shared Neighborhood Hits	204
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ABR_HUMAN
NC score	0.980929 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	204	Target Neighborhood Hits	166	Shared Neighborhood Hits	134
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

RHG09_HUMAN
NC score	0.752034 (rank : 3)	θ value	1.33526e-19 (rank : 23)
Query Neighborhood Hits	204	Target Neighborhood Hits	186	Shared Neighborhood Hits	71
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

RHG12_HUMAN
NC score	0.726408 (rank : 4)	θ value	1.12775e-26 (rank : 7)
Query Neighborhood Hits	204	Target Neighborhood Hits	190	Shared Neighborhood Hits	65
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
NC score	0.724094 (rank : 5)	θ value	6.61148e-27 (rank : 5)
Query Neighborhood Hits	204	Target Neighborhood Hits	204	Shared Neighborhood Hits	65
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

TCGAP_MOUSE
NC score	0.718903 (rank : 6)	θ value	5.42112e-21 (rank : 15)
Query Neighborhood Hits	204	Target Neighborhood Hits	409	Shared Neighborhood Hits	99
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

GMIP_MOUSE
NC score	0.718338 (rank : 7)	θ value	6.62687e-19 (rank : 27)
Query Neighborhood Hits	204	Target Neighborhood Hits	202	Shared Neighborhood Hits	74
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

RGAP1_HUMAN
NC score	0.718298 (rank : 8)	θ value	2.69047e-20 (rank : 19)
Query Neighborhood Hits	204	Target Neighborhood Hits	189	Shared Neighborhood Hits	68
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RGAP1_MOUSE
NC score	0.717550 (rank : 9)	θ value	1.80466e-16 (rank : 37)
Query Neighborhood Hits	204	Target Neighborhood Hits	185	Shared Neighborhood Hits	68
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

GMIP_HUMAN
NC score	0.716255 (rank : 10)	θ value	1.74391e-19 (rank : 24)
Query Neighborhood Hits	204	Target Neighborhood Hits	225	Shared Neighborhood Hits	72
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

3BP1_MOUSE
NC score	0.711048 (rank : 11)	θ value	5.60996e-18 (rank : 31)
Query Neighborhood Hits	204	Target Neighborhood Hits	238	Shared Neighborhood Hits	78
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

CHIO_MOUSE
NC score	0.709550 (rank : 12)	θ value	1.12775e-26 (rank : 6)
Query Neighborhood Hits	204	Target Neighborhood Hits	130	Shared Neighborhood Hits	70
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

GRLF1_HUMAN
NC score	0.705454 (rank : 13)	θ value	1.42661e-21 (rank : 13)
Query Neighborhood Hits	204	Target Neighborhood Hits	167	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

3BP1_HUMAN
NC score	0.704113 (rank : 14)	θ value	8.36355e-22 (rank : 12)
Query Neighborhood Hits	204	Target Neighborhood Hits	376	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

RHG06_HUMAN
NC score	0.693040 (rank : 15)	θ value	2.20605e-14 (rank : 44)
Query Neighborhood Hits	204	Target Neighborhood Hits	114	Shared Neighborhood Hits	66
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG06_MOUSE
NC score	0.691886 (rank : 16)	θ value	6.41864e-14 (rank : 45)
Query Neighborhood Hits	204	Target Neighborhood Hits	105	Shared Neighborhood Hits	63
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

CHIN_HUMAN
NC score	0.685547 (rank : 17)	θ value	6.38894e-30 (rank : 4)
Query Neighborhood Hits	204	Target Neighborhood Hits	227	Shared Neighborhood Hits	72
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
NC score	0.685514 (rank : 18)	θ value	1.6813e-30 (rank : 3)
Query Neighborhood Hits	204	Target Neighborhood Hits	229	Shared Neighborhood Hits	72
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
NC score	0.681042 (rank : 19)	θ value	3.28125e-26 (rank : 8)
Query Neighborhood Hits	204	Target Neighborhood Hits	220	Shared Neighborhood Hits	71
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

RHG05_MOUSE
NC score	0.680452 (rank : 20)	θ value	7.0802e-21 (rank : 17)
Query Neighborhood Hits	204	Target Neighborhood Hits	165	Shared Neighborhood Hits	64
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG04_HUMAN
NC score	0.673829 (rank : 21)	θ value	5.60996e-18 (rank : 32)
Query Neighborhood Hits	204	Target Neighborhood Hits	307	Shared Neighborhood Hits	80
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RHG05_HUMAN
NC score	0.672102 (rank : 22)	θ value	2.06002e-20 (rank : 18)
Query Neighborhood Hits	204	Target Neighborhood Hits	158	Shared Neighborhood Hits	62
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG18_HUMAN
NC score	0.671531 (rank : 23)	θ value	6.21693e-09 (rank : 73)
Query Neighborhood Hits	204	Target Neighborhood Hits	90	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

RHG26_HUMAN
NC score	0.668015 (rank : 24)	θ value	1.74391e-19 (rank : 25)
Query Neighborhood Hits	204	Target Neighborhood Hits	281	Shared Neighborhood Hits	80
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RHG18_MOUSE
NC score	0.668006 (rank : 25)	θ value	1.58096e-12 (rank : 56)
Query Neighborhood Hits	204	Target Neighborhood Hits	110	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

OPHN1_HUMAN
NC score	0.667982 (rank : 26)	θ value	2.20605e-14 (rank : 43)
Query Neighborhood Hits	204	Target Neighborhood Hits	161	Shared Neighborhood Hits	65
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

OPHN1_MOUSE
NC score	0.667640 (rank : 27)	θ value	7.58209e-15 (rank : 42)
Query Neighborhood Hits	204	Target Neighborhood Hits	174	Shared Neighborhood Hits	66
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

RHG01_HUMAN
NC score	0.663466 (rank : 28)	θ value	7.09661e-13 (rank : 52)
Query Neighborhood Hits	204	Target Neighborhood Hits	75	Shared Neighborhood Hits	63
SwissProt Accessions	Q07960	Gene names	ARHGAP1, CDC42GAP, RHOGAP1
Domain Architecture
Description	Rho-GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (CDC42 GTPase-activating protein) (p50-RhoGAP).

SRGP2_HUMAN
NC score	0.656199 (rank : 29)	θ value	2.97466e-19 (rank : 26)
Query Neighborhood Hits	204	Target Neighborhood Hits	331	Shared Neighborhood Hits	82
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

RHG08_MOUSE
NC score	0.655575 (rank : 30)	θ value	7.09661e-13 (rank : 53)
Query Neighborhood Hits	204	Target Neighborhood Hits	73	Shared Neighborhood Hits	62
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

RBP1_MOUSE
NC score	0.653823 (rank : 31)	θ value	4.43474e-23 (rank : 10)
Query Neighborhood Hits	204	Target Neighborhood Hits	493	Shared Neighborhood Hits	67
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RHG08_HUMAN
NC score	0.650634 (rank : 32)	θ value	9.26847e-13 (rank : 55)
Query Neighborhood Hits	204	Target Neighborhood Hits	88	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NSG0, O75983, O95695, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NVX8, Q9NXL1, Q9UH20	Gene names	ARHGAP8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

SRGP2_MOUSE
NC score	0.649705 (rank : 33)	θ value	1.13037e-18 (rank : 28)
Query Neighborhood Hits	204	Target Neighborhood Hits	324	Shared Neighborhood Hits	81
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRGP1_HUMAN
NC score	0.647592 (rank : 34)	θ value	5.99374e-20 (rank : 21)
Query Neighborhood Hits	204	Target Neighborhood Hits	390	Shared Neighborhood Hits	81
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

RHG25_MOUSE
NC score	0.644152 (rank : 35)	θ value	5.25075e-16 (rank : 39)
Query Neighborhood Hits	204	Target Neighborhood Hits	492	Shared Neighborhood Hits	78
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

TCGAP_HUMAN
NC score	0.640773 (rank : 36)	θ value	5.42112e-21 (rank : 14)
Query Neighborhood Hits	204	Target Neighborhood Hits	872	Shared Neighborhood Hits	104
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

FNBP2_HUMAN
NC score	0.638779 (rank : 37)	θ value	1.47631e-18 (rank : 29)
Query Neighborhood Hits	204	Target Neighborhood Hits	432	Shared Neighborhood Hits	81
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

RBP1_HUMAN
NC score	0.638423 (rank : 38)	θ value	3.39556e-23 (rank : 9)
Query Neighborhood Hits	204	Target Neighborhood Hits	521	Shared Neighborhood Hits	67
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RHG25_HUMAN
NC score	0.621112 (rank : 39)	θ value	5.8054e-15 (rank : 41)
Query Neighborhood Hits	204	Target Neighborhood Hits	550	Shared Neighborhood Hits	74
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG07_MOUSE
NC score	0.601564 (rank : 40)	θ value	2.43908e-13 (rank : 50)
Query Neighborhood Hits	204	Target Neighborhood Hits	103	Shared Neighborhood Hits	62
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

RHG07_HUMAN
NC score	0.595577 (rank : 41)	θ value	5.43371e-13 (rank : 51)
Query Neighborhood Hits	204	Target Neighborhood Hits	108	Shared Neighborhood Hits	62
SwissProt Accessions	Q96QB1, O14868, O43199, Q9C0E0	Gene names	DLC1, ARHGAP7, KIAA1723, STARD12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

CEND2_HUMAN
NC score	0.570079 (rank : 42)	θ value	6.20254e-17 (rank : 33)
Query Neighborhood Hits	204	Target Neighborhood Hits	166	Shared Neighborhood Hits	71
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

STAR8_MOUSE
NC score	0.568653 (rank : 43)	θ value	6.00763e-12 (rank : 60)
Query Neighborhood Hits	204	Target Neighborhood Hits	101	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STA13_HUMAN
NC score	0.563220 (rank : 44)	θ value	1.9326e-10 (rank : 69)
Query Neighborhood Hits	204	Target Neighborhood Hits	89	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

STAR8_HUMAN
NC score	0.562763 (rank : 45)	θ value	5.08577e-11 (rank : 66)
Query Neighborhood Hits	204	Target Neighborhood Hits	216	Shared Neighborhood Hits	66
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STA13_MOUSE
NC score	0.553312 (rank : 46)	θ value	2.13673e-09 (rank : 72)
Query Neighborhood Hits	204	Target Neighborhood Hits	89	Shared Neighborhood Hits	58
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

TAGAP_HUMAN
NC score	0.550174 (rank : 47)	θ value	0.365318 (rank : 130)
Query Neighborhood Hits	204	Target Neighborhood Hits	82	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

TAGAP_MOUSE
NC score	0.549292 (rank : 48)	θ value	1.38821 (rank : 141)
Query Neighborhood Hits	204	Target Neighborhood Hits	83	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

CE005_HUMAN
NC score	0.545947 (rank : 49)	θ value	2.36244e-08 (rank : 75)
Query Neighborhood Hits	204	Target Neighborhood Hits	213	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

CE005_MOUSE
NC score	0.542872 (rank : 50)	θ value	2.36244e-08 (rank : 76)
Query Neighborhood Hits	204	Target Neighborhood Hits	238	Shared Neighborhood Hits	62
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

CEND3_MOUSE
NC score	0.535814 (rank : 51)	θ value	1.09485e-13 (rank : 46)
Query Neighborhood Hits	204	Target Neighborhood Hits	228	Shared Neighborhood Hits	68
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CEND3_HUMAN
NC score	0.526540 (rank : 52)	θ value	1.86753e-13 (rank : 48)
Query Neighborhood Hits	204	Target Neighborhood Hits	275	Shared Neighborhood Hits	72
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CEND1_MOUSE
NC score	0.492928 (rank : 53)	θ value	2.43908e-13 (rank : 49)
Query Neighborhood Hits	204	Target Neighborhood Hits	260	Shared Neighborhood Hits	67
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

K1688_MOUSE
NC score	0.484493 (rank : 54)	θ value	2.61198e-07 (rank : 85)
Query Neighborhood Hits	204	Target Neighborhood Hits	188	Shared Neighborhood Hits	61
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

K1688_HUMAN
NC score	0.478155 (rank : 55)	θ value	8.97725e-08 (rank : 79)
Query Neighborhood Hits	204	Target Neighborhood Hits	217	Shared Neighborhood Hits	65
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

ECT2_MOUSE
NC score	0.475836 (rank : 56)	θ value	4.29542e-18 (rank : 30)
Query Neighborhood Hits	204	Target Neighborhood Hits	98	Shared Neighborhood Hits	62
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHGA_MOUSE
NC score	0.474625 (rank : 57)	θ value	7.82807e-20 (rank : 22)
Query Neighborhood Hits	204	Target Neighborhood Hits	125	Shared Neighborhood Hits	60
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_HUMAN
NC score	0.474541 (rank : 58)	θ value	4.9032e-22 (rank : 11)
Query Neighborhood Hits	204	Target Neighborhood Hits	187	Shared Neighborhood Hits	65
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

CEND1_HUMAN
NC score	0.471490 (rank : 59)	θ value	6.64225e-11 (rank : 67)
Query Neighborhood Hits	204	Target Neighborhood Hits	284	Shared Neighborhood Hits	68
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

ECT2_HUMAN
NC score	0.468695 (rank : 60)	θ value	6.20254e-17 (rank : 34)
Query Neighborhood Hits	204	Target Neighborhood Hits	98	Shared Neighborhood Hits	63
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

PREX1_HUMAN
NC score	0.438653 (rank : 61)	θ value	1.38178e-16 (rank : 36)
Query Neighborhood Hits	204	Target Neighborhood Hits	177	Shared Neighborhood Hits	64
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

FGD3_MOUSE
NC score	0.434823 (rank : 62)	θ value	2.98157e-11 (rank : 63)
Query Neighborhood Hits	204	Target Neighborhood Hits	257	Shared Neighborhood Hits	63
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD2_HUMAN
NC score	0.428753 (rank : 63)	θ value	9.26847e-13 (rank : 54)
Query Neighborhood Hits	204	Target Neighborhood Hits	151	Shared Neighborhood Hits	63
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD4_MOUSE
NC score	0.425695 (rank : 64)	θ value	4.59992e-12 (rank : 59)
Query Neighborhood Hits	204	Target Neighborhood Hits	227	Shared Neighborhood Hits	68
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD4_HUMAN
NC score	0.423895 (rank : 65)	θ value	5.08577e-11 (rank : 65)
Query Neighborhood Hits	204	Target Neighborhood Hits	219	Shared Neighborhood Hits	67
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD3_HUMAN
NC score	0.422045 (rank : 66)	θ value	1.63604e-09 (rank : 71)
Query Neighborhood Hits	204	Target Neighborhood Hits	249	Shared Neighborhood Hits	62
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD2_MOUSE
NC score	0.418923 (rank : 67)	θ value	5.08577e-11 (rank : 64)
Query Neighborhood Hits	204	Target Neighborhood Hits	163	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD1_HUMAN
NC score	0.411898 (rank : 68)	θ value	7.84624e-12 (rank : 61)
Query Neighborhood Hits	204	Target Neighborhood Hits	367	Shared Neighborhood Hits	74
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
NC score	0.411132 (rank : 69)	θ value	2.69671e-12 (rank : 58)
Query Neighborhood Hits	204	Target Neighborhood Hits	387	Shared Neighborhood Hits	72
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD6_MOUSE
NC score	0.410662 (rank : 70)	θ value	5.25075e-16 (rank : 38)
Query Neighborhood Hits	204	Target Neighborhood Hits	282	Shared Neighborhood Hits	67
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD6_HUMAN
NC score	0.409511 (rank : 71)	θ value	1.16975e-15 (rank : 40)
Query Neighborhood Hits	204	Target Neighborhood Hits	237	Shared Neighborhood Hits	62
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

ARHG4_HUMAN
NC score	0.400404 (rank : 72)	θ value	1.99992e-07 (rank : 81)
Query Neighborhood Hits	204	Target Neighborhood Hits	242	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
NC score	0.397934 (rank : 73)	θ value	2.61198e-07 (rank : 83)
Query Neighborhood Hits	204	Target Neighborhood Hits	185	Shared Neighborhood Hits	63
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PKHG1_HUMAN
NC score	0.390750 (rank : 74)	θ value	4.92598e-06 (rank : 90)
Query Neighborhood Hits	204	Target Neighborhood Hits	174	Shared Neighborhood Hits	62
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHG9_HUMAN
NC score	0.389910 (rank : 75)	θ value	8.40245e-06 (rank : 91)
Query Neighborhood Hits	204	Target Neighborhood Hits	235	Shared Neighborhood Hits	68
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.389699 (rank : 76)	θ value	8.40245e-06 (rank : 92)
Query Neighborhood Hits	204	Target Neighborhood Hits	234	Shared Neighborhood Hits	68
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG8_HUMAN
NC score	0.377787 (rank : 77)	θ value	2.61198e-07 (rank : 84)
Query Neighborhood Hits	204	Target Neighborhood Hits	85	Shared Neighborhood Hits	60
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

P85A_HUMAN
NC score	0.375376 (rank : 78)	θ value	1.80886e-08 (rank : 74)
Query Neighborhood Hits	204	Target Neighborhood Hits	479	Shared Neighborhood Hits	73
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

MYO9B_MOUSE
NC score	0.373603 (rank : 79)	θ value	7.0802e-21 (rank : 16)
Query Neighborhood Hits	204	Target Neighborhood Hits	311	Shared Neighborhood Hits	78
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

ARHG3_HUMAN
NC score	0.373221 (rank : 80)	θ value	2.61198e-07 (rank : 82)
Query Neighborhood Hits	204	Target Neighborhood Hits	82	Shared Neighborhood Hits	57
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

GNRP_MOUSE
NC score	0.372991 (rank : 81)	θ value	8.10077e-17 (rank : 35)
Query Neighborhood Hits	204	Target Neighborhood Hits	191	Shared Neighborhood Hits	58
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ARHG3_MOUSE
NC score	0.371588 (rank : 82)	θ value	1.99992e-07 (rank : 80)
Query Neighborhood Hits	204	Target Neighborhood Hits	85	Shared Neighborhood Hits	57
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

MYO9B_HUMAN
NC score	0.369371 (rank : 83)	θ value	4.58923e-20 (rank : 20)
Query Neighborhood Hits	204	Target Neighborhood Hits	641	Shared Neighborhood Hits	89
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

P85A_MOUSE
NC score	0.364045 (rank : 84)	θ value	0.000786445 (rank : 104)
Query Neighborhood Hits	204	Target Neighborhood Hits	435	Shared Neighborhood Hits	73
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

ARHG5_HUMAN
NC score	0.360649 (rank : 85)	θ value	0.000121331 (rank : 98)
Query Neighborhood Hits	204	Target Neighborhood Hits	172	Shared Neighborhood Hits	65
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

GNRP_HUMAN
NC score	0.353892 (rank : 86)	θ value	1.09485e-13 (rank : 47)
Query Neighborhood Hits	204	Target Neighborhood Hits	239	Shared Neighborhood Hits	58
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

ARHG8_MOUSE
NC score	0.346537 (rank : 87)	θ value	5.44631e-05 (rank : 97)
Query Neighborhood Hits	204	Target Neighborhood Hits	79	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

MCF2_HUMAN
NC score	0.342094 (rank : 88)	θ value	8.40245e-06 (rank : 93)
Query Neighborhood Hits	204	Target Neighborhood Hits	166	Shared Neighborhood Hits	61
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ARHGG_MOUSE
NC score	0.340389 (rank : 89)	θ value	0.00035302 (rank : 102)
Query Neighborhood Hits	204	Target Neighborhood Hits	152	Shared Neighborhood Hits	62
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_HUMAN
NC score	0.335339 (rank : 90)	θ value	0.0113563 (rank : 113)
Query Neighborhood Hits	204	Target Neighborhood Hits	129	Shared Neighborhood Hits	61
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

DNMBP_MOUSE
NC score	0.334970 (rank : 91)	θ value	3.41135e-07 (rank : 86)
Query Neighborhood Hits	204	Target Neighborhood Hits	435	Shared Neighborhood Hits	83
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

NGEF_HUMAN
NC score	0.331444 (rank : 92)	θ value	0.0961366 (rank : 117)
Query Neighborhood Hits	204	Target Neighborhood Hits	166	Shared Neighborhood Hits	63
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

FGD5_HUMAN
NC score	0.331097 (rank : 93)	θ value	4.92598e-06 (rank : 89)
Query Neighborhood Hits	204	Target Neighborhood Hits	235	Shared Neighborhood Hits	50
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

DNMBP_HUMAN
NC score	0.327547 (rank : 94)	θ value	4.45536e-07 (rank : 87)
Query Neighborhood Hits	204	Target Neighborhood Hits	413	Shared Neighborhood Hits	76
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

TIAM1_MOUSE
NC score	0.323962 (rank : 95)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	204	Target Neighborhood Hits	205	Shared Neighborhood Hits	67
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_HUMAN
NC score	0.323878 (rank : 96)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	204	Target Neighborhood Hits	225	Shared Neighborhood Hits	71
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

NGEF_MOUSE
NC score	0.322927 (rank : 97)	θ value	0.0961366 (rank : 118)
Query Neighborhood Hits	204	Target Neighborhood Hits	228	Shared Neighborhood Hits	65
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

FGD5_MOUSE
NC score	0.315493 (rank : 98)	θ value	0.000270298 (rank : 101)
Query Neighborhood Hits	204	Target Neighborhood Hits	170	Shared Neighborhood Hits	46
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

ARHG7_MOUSE
NC score	0.314255 (rank : 99)	θ value	0.00020696 (rank : 100)
Query Neighborhood Hits	204	Target Neighborhood Hits	396	Shared Neighborhood Hits	69
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHGF_HUMAN
NC score	0.311839 (rank : 100)	θ value	0.00390308 (rank : 108)
Query Neighborhood Hits	204	Target Neighborhood Hits	214	Shared Neighborhood Hits	71
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHG7_HUMAN
NC score	0.307991 (rank : 101)	θ value	0.00175202 (rank : 106)
Query Neighborhood Hits	204	Target Neighborhood Hits	347	Shared Neighborhood Hits	70
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

MCF2L_MOUSE
NC score	0.307327 (rank : 102)	θ value	0.0193708 (rank : 115)
Query Neighborhood Hits	204	Target Neighborhood Hits	255	Shared Neighborhood Hits	62
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

VAV3_MOUSE
NC score	0.298473 (rank : 103)	θ value	3.19293e-05 (rank : 96)
Query Neighborhood Hits	204	Target Neighborhood Hits	404	Shared Neighborhood Hits	81
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV3_HUMAN
NC score	0.296568 (rank : 104)	θ value	1.43324e-05 (rank : 95)
Query Neighborhood Hits	204	Target Neighborhood Hits	398	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

FARP2_MOUSE
NC score	0.296469 (rank : 105)	θ value	6.87365e-08 (rank : 78)
Query Neighborhood Hits	204	Target Neighborhood Hits	209	Shared Neighborhood Hits	71
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ITSN2_HUMAN
NC score	0.293872 (rank : 106)	θ value	8.67504e-11 (rank : 68)
Query Neighborhood Hits	204	Target Neighborhood Hits	1173	Shared Neighborhood Hits	96
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

HAPIP_HUMAN
NC score	0.293617 (rank : 107)	θ value	0.000158464 (rank : 99)
Query Neighborhood Hits	204	Target Neighborhood Hits	350	Shared Neighborhood Hits	63
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

I5P2_HUMAN
NC score	0.292456 (rank : 108)	θ value	0.00228821 (rank : 107)
Query Neighborhood Hits	204	Target Neighborhood Hits	86	Shared Neighborhood Hits	52
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

FARP2_HUMAN
NC score	0.285152 (rank : 109)	θ value	4.0297e-08 (rank : 77)
Query Neighborhood Hits	204	Target Neighborhood Hits	240	Shared Neighborhood Hits	67
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

OCRL_HUMAN
NC score	0.281142 (rank : 110)	θ value	0.0252991 (rank : 116)
Query Neighborhood Hits	204	Target Neighborhood Hits	77	Shared Neighborhood Hits	51
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).

VAV_MOUSE
NC score	0.280755 (rank : 111)	θ value	0.000786445 (rank : 105)
Query Neighborhood Hits	204	Target Neighborhood Hits	430	Shared Neighborhood Hits	84
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ARHG6_HUMAN
NC score	0.279207 (rank : 112)	θ value	0.000461057 (rank : 103)
Query Neighborhood Hits	204	Target Neighborhood Hits	376	Shared Neighborhood Hits	60
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ITSN1_HUMAN
NC score	0.278658 (rank : 113)	θ value	1.33837e-11 (rank : 62)
Query Neighborhood Hits	204	Target Neighborhood Hits	1757	Shared Neighborhood Hits	113
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN2_MOUSE
NC score	0.278608 (rank : 114)	θ value	3.29651e-10 (rank : 70)
Query Neighborhood Hits	204	Target Neighborhood Hits	1371	Shared Neighborhood Hits	99
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ITSN1_MOUSE
NC score	0.278044 (rank : 115)	θ value	2.0648e-12 (rank : 57)
Query Neighborhood Hits	204	Target Neighborhood Hits	1669	Shared Neighborhood Hits	112
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ARHGB_HUMAN
NC score	0.270887 (rank : 116)	θ value	0.00509761 (rank : 110)
Query Neighborhood Hits	204	Target Neighborhood Hits	375	Shared Neighborhood Hits	64
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

VAV2_MOUSE
NC score	0.269759 (rank : 117)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	204	Target Neighborhood Hits	456	Shared Neighborhood Hits	81
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ARHG1_HUMAN
NC score	0.268685 (rank : 118)	θ value	0.365318 (rank : 127)
Query Neighborhood Hits	204	Target Neighborhood Hits	176	Shared Neighborhood Hits	55
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

VAV2_HUMAN
NC score	0.268435 (rank : 119)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	204	Target Neighborhood Hits	453	Shared Neighborhood Hits	80
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ARHG6_MOUSE
NC score	0.268054 (rank : 120)	θ value	0.00509761 (rank : 109)
Query Neighborhood Hits	204	Target Neighborhood Hits	394	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

VAV_HUMAN
NC score	0.265210 (rank : 121)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	204	Target Neighborhood Hits	452	Shared Neighborhood Hits	86
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

PKHG4_HUMAN
NC score	0.263056 (rank : 122)	θ value	0.62314 (rank : 132)
Query Neighborhood Hits	204	Target Neighborhood Hits	200	Shared Neighborhood Hits	53
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

ARHG1_MOUSE
NC score	0.253980 (rank : 123)	θ value	0.125558 (rank : 119)
Query Neighborhood Hits	204	Target Neighborhood Hits	266	Shared Neighborhood Hits	57
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

FARP1_HUMAN
NC score	0.252895 (rank : 124)	θ value	0.00509761 (rank : 111)
Query Neighborhood Hits	204	Target Neighborhood Hits	241	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

ARHG2_MOUSE
NC score	0.246350 (rank : 125)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	204	Target Neighborhood Hits	120	Shared Neighborhood Hits	60
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG2_HUMAN
NC score	0.224847 (rank : 126)	θ value	3.0926 (rank : 155)
Query Neighborhood Hits	204	Target Neighborhood Hits	142	Shared Neighborhood Hits	57
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

LBC_HUMAN
NC score	0.222105 (rank : 127)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	204	Target Neighborhood Hits	90	Shared Neighborhood Hits	47
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHGC_HUMAN
NC score	0.222041 (rank : 128)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	204	Target Neighborhood Hits	351	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
NC score	0.220514 (rank : 129)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	204	Target Neighborhood Hits	344	Shared Neighborhood Hits	60
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

RGNEF_MOUSE
NC score	0.209077 (rank : 130)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	204	Target Neighborhood Hits	641	Shared Neighborhood Hits	67
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

SOS1_HUMAN
NC score	0.149216 (rank : 131)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	204	Target Neighborhood Hits	274	Shared Neighborhood Hits	43
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

PKHF2_HUMAN
NC score	0.145049 (rank : 132)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	204	Target Neighborhood Hits	75	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
NC score	0.144674 (rank : 133)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	204	Target Neighborhood Hits	77	Shared Neighborhood Hits	19
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHF1_MOUSE
NC score	0.141593 (rank : 134)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	204	Target Neighborhood Hits	80	Shared Neighborhood Hits	21
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

SOS1_MOUSE
NC score	0.141167 (rank : 135)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	204	Target Neighborhood Hits	281	Shared Neighborhood Hits	43
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

PKHF1_HUMAN
NC score	0.140100 (rank : 136)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	204	Target Neighborhood Hits	76	Shared Neighborhood Hits	18
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

P85B_HUMAN
NC score	0.138169 (rank : 137)	θ value	0.163984 (rank : 121)
Query Neighborhood Hits	204	Target Neighborhood Hits	543	Shared Neighborhood Hits	38
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SOS2_HUMAN
NC score	0.132282 (rank : 138)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	204	Target Neighborhood Hits	193	Shared Neighborhood Hits	40
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SH3K1_HUMAN
NC score	0.123914 (rank : 139)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	204	Target Neighborhood Hits	341	Shared Neighborhood Hits	38
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

NCK2_HUMAN
NC score	0.123521 (rank : 140)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	204	Target Neighborhood Hits	310	Shared Neighborhood Hits	43
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

SH3K1_MOUSE
NC score	0.121155 (rank : 141)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	204	Target Neighborhood Hits	332	Shared Neighborhood Hits	37
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SRBS1_MOUSE
NC score	0.120179 (rank : 142)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	204	Target Neighborhood Hits	409	Shared Neighborhood Hits	47
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

DUET_HUMAN
NC score	0.120086 (rank : 143)	θ value	4.92598e-06 (rank : 88)
Query Neighborhood Hits	204	Target Neighborhood Hits	1220	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

GRP3_HUMAN
NC score	0.119576 (rank : 144)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	204	Target Neighborhood Hits	131	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

VINEX_MOUSE
NC score	0.119448 (rank : 145)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	204	Target Neighborhood Hits	286	Shared Neighborhood Hits	41
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

CD2AP_HUMAN
NC score	0.119070 (rank : 146)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	204	Target Neighborhood Hits	315	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SRBS1_HUMAN
NC score	0.118113 (rank : 147)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	204	Target Neighborhood Hits	396	Shared Neighborhood Hits	47
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

VINEX_HUMAN
NC score	0.117152 (rank : 148)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	204	Target Neighborhood Hits	270	Shared Neighborhood Hits	43
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

CD2AP_MOUSE
NC score	0.113518 (rank : 149)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	204	Target Neighborhood Hits	336	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

P85B_MOUSE
NC score	0.112686 (rank : 150)	θ value	0.00665767 (rank : 112)
Query Neighborhood Hits	204	Target Neighborhood Hits	519	Shared Neighborhood Hits	34
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

GRAP_HUMAN
NC score	0.112468 (rank : 151)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	204	Target Neighborhood Hits	307	Shared Neighborhood Hits	36
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

TRIO_HUMAN
NC score	0.111287 (rank : 152)	θ value	1.09739e-05 (rank : 94)
Query Neighborhood Hits	204	Target Neighborhood Hits	1580	Shared Neighborhood Hits	79
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

NCF2_HUMAN
NC score	0.111011 (rank : 153)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	204	Target Neighborhood Hits	229	Shared Neighborhood Hits	37
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCK1_HUMAN
NC score	0.110992 (rank : 154)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	204	Target Neighborhood Hits	312	Shared Neighborhood Hits	37
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

STAC3_MOUSE
NC score	0.110415 (rank : 155)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	204	Target Neighborhood Hits	232	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

NCF4_MOUSE
NC score	0.109937 (rank : 156)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	204	Target Neighborhood Hits	177	Shared Neighborhood Hits	27
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

GRAP_MOUSE
NC score	0.108695 (rank : 157)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	204	Target Neighborhood Hits	309	Shared Neighborhood Hits	37
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

STAC3_HUMAN
NC score	0.108523 (rank : 158)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	204	Target Neighborhood Hits	228	Shared Neighborhood Hits	36
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

NCF4_HUMAN
NC score	0.106339 (rank : 159)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	204	Target Neighborhood Hits	161	Shared Neighborhood Hits	23
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

GRB2_HUMAN
NC score	0.106205 (rank : 160)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	204	Target Neighborhood Hits	310	Shared Neighborhood Hits	34
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.106178 (rank : 161)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	204	Target Neighborhood Hits	312	Shared Neighborhood Hits	34
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

STAC_MOUSE
NC score	0.102902 (rank : 162)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	204	Target Neighborhood Hits	268	Shared Neighborhood Hits	36
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_HUMAN
NC score	0.099988 (rank : 163)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	204	Target Neighborhood Hits	276	Shared Neighborhood Hits	36
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

HCLS1_MOUSE
NC score	0.097837 (rank : 164)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	204	Target Neighborhood Hits	329	Shared Neighborhood Hits	36
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HCLS1_HUMAN
NC score	0.097508 (rank : 165)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	204	Target Neighborhood Hits	358	Shared Neighborhood Hits	36
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

NCF1_MOUSE
NC score	0.096084 (rank : 166)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	204	Target Neighborhood Hits	198	Shared Neighborhood Hits	30
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

ABI2_HUMAN
NC score	0.095588 (rank : 167)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	204	Target Neighborhood Hits	350	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
NC score	0.095351 (rank : 168)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	204	Target Neighborhood Hits	266	Shared Neighborhood Hits	32
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

NCF1_HUMAN
NC score	0.092966 (rank : 169)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	204	Target Neighborhood Hits	198	Shared Neighborhood Hits	28
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

GRAP2_HUMAN
NC score	0.092262 (rank : 170)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	204	Target Neighborhood Hits	304	Shared Neighborhood Hits	35
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

ZFY28_HUMAN
NC score	0.091623 (rank : 171)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	204	Target Neighborhood Hits	152	Shared Neighborhood Hits	14
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

PKHA6_MOUSE
NC score	0.091293 (rank : 172)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	204	Target Neighborhood Hits	591	Shared Neighborhood Hits	35
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

CRKL_HUMAN
NC score	0.091256 (rank : 173)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	204	Target Neighborhood Hits	313	Shared Neighborhood Hits	34
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

ZFYV9_HUMAN
NC score	0.090603 (rank : 174)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	204	Target Neighborhood Hits	134	Shared Neighborhood Hits	13
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

GRAP2_MOUSE
NC score	0.090353 (rank : 175)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	204	Target Neighborhood Hits	297	Shared Neighborhood Hits	33
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

PKHA6_HUMAN
NC score	0.088565 (rank : 176)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	204	Target Neighborhood Hits	556	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

UN13A_HUMAN
NC score	0.087349 (rank : 177)	θ value	5.27518 (rank : 178)
Query Neighborhood Hits	204	Target Neighborhood Hits	285	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

ABI1_MOUSE
NC score	0.087263 (rank : 178)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	204	Target Neighborhood Hits	246	Shared Neighborhood Hits	32
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ZFY16_MOUSE
NC score	0.087065 (rank : 179)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	204	Target Neighborhood Hits	108	Shared Neighborhood Hits	14
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

PPIP1_HUMAN
NC score	0.085714 (rank : 180)	θ value	4.03905 (rank : 165)
Query Neighborhood Hits	204	Target Neighborhood Hits	389	Shared Neighborhood Hits	35
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

CRKL_MOUSE
NC score	0.085026 (rank : 181)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	204	Target Neighborhood Hits	307	Shared Neighborhood Hits	33
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

DDEF2_HUMAN
NC score	0.085010 (rank : 182)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	204	Target Neighborhood Hits	599	Shared Neighborhood Hits	51
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

UN13B_HUMAN
NC score	0.084827 (rank : 183)	θ value	1.81305 (rank : 145)
Query Neighborhood Hits	204	Target Neighborhood Hits	217	Shared Neighborhood Hits	34
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

ZFY16_HUMAN
NC score	0.084035 (rank : 184)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	204	Target Neighborhood Hits	125	Shared Neighborhood Hits	12
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY21_MOUSE
NC score	0.083846 (rank : 185)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	204	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

DDEF2_MOUSE
NC score	0.083833 (rank : 186)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	204	Target Neighborhood Hits	625	Shared Neighborhood Hits	46
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

SRC8_MOUSE
NC score	0.083190 (rank : 187)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	204	Target Neighborhood Hits	292	Shared Neighborhood Hits	31
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

UN13B_MOUSE
NC score	0.082719 (rank : 188)	θ value	2.36792 (rank : 154)
Query Neighborhood Hits	204	Target Neighborhood Hits	210	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

ZFY21_HUMAN
NC score	0.081932 (rank : 189)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	204	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ABI1_HUMAN
NC score	0.081038 (rank : 190)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	204	Target Neighborhood Hits	257	Shared Neighborhood Hits	34
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

SRC8_HUMAN
NC score	0.081019 (rank : 191)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	204	Target Neighborhood Hits	269	Shared Neighborhood Hits	31
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

DDEF1_MOUSE
NC score	0.079264 (rank : 192)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	204	Target Neighborhood Hits	592	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

CENB2_HUMAN
NC score	0.078688 (rank : 193)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	204	Target Neighborhood Hits	425	Shared Neighborhood Hits	21
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

STAM1_MOUSE
NC score	0.077745 (rank : 194)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	204	Target Neighborhood Hits	273	Shared Neighborhood Hits	29
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_HUMAN
NC score	0.077512 (rank : 195)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	204	Target Neighborhood Hits	271	Shared Neighborhood Hits	30
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

CRK_MOUSE
NC score	0.077171 (rank : 196)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	204	Target Neighborhood Hits	314	Shared Neighborhood Hits	31
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

PPIP1_MOUSE
NC score	0.076634 (rank : 197)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	204	Target Neighborhood Hits	377	Shared Neighborhood Hits	36
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

NPHP1_MOUSE
NC score	0.076046 (rank : 198)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	204	Target Neighborhood Hits	267	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

CRK_HUMAN
NC score	0.075988 (rank : 199)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	204	Target Neighborhood Hits	308	Shared Neighborhood Hits	30
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

STAM2_MOUSE
NC score	0.075294 (rank : 200)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	204	Target Neighborhood Hits	285	Shared Neighborhood Hits	30
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

SH3G1_HUMAN
NC score	0.075270 (rank : 201)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	204	Target Neighborhood Hits	307	Shared Neighborhood Hits	32
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

STAM2_HUMAN
NC score	0.074994 (rank : 202)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	204	Target Neighborhood Hits	288	Shared Neighborhood Hits	30
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

SH3G2_MOUSE
NC score	0.074470 (rank : 203)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	204	Target Neighborhood Hits	319	Shared Neighborhood Hits	30
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

CENB5_HUMAN
NC score	0.074344 (rank : 204)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	204	Target Neighborhood Hits	395	Shared Neighborhood Hits	21
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

SH3G2_HUMAN
NC score	0.074220 (rank : 205)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	204	Target Neighborhood Hits	324	Shared Neighborhood Hits	31
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

P55G_HUMAN
NC score	0.072584 (rank : 206)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	204	Target Neighborhood Hits	451	Shared Neighborhood Hits	16
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

SH3G1_MOUSE
NC score	0.072028 (rank : 207)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	204	Target Neighborhood Hits	291	Shared Neighborhood Hits	29
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

P55G_MOUSE
NC score	0.071865 (rank : 208)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	204	Target Neighborhood Hits	401	Shared Neighborhood Hits	15
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

SH3G3_HUMAN
NC score	0.071176 (rank : 209)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	204	Target Neighborhood Hits	222	Shared Neighborhood Hits	29
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
NC score	0.071141 (rank : 210)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	204	Target Neighborhood Hits	236	Shared Neighborhood Hits	29
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

NPHP1_HUMAN
NC score	0.070998 (rank : 211)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	204	Target Neighborhood Hits	288	Shared Neighborhood Hits	27
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

CENB1_HUMAN
NC score	0.070971 (rank : 212)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	204	Target Neighborhood Hits	383	Shared Neighborhood Hits	20
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

HGS_MOUSE
NC score	0.070286 (rank : 213)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	204	Target Neighborhood Hits	589	Shared Neighborhood Hits	31
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

OSTF1_HUMAN
NC score	0.069905 (rank : 214)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	204	Target Neighborhood Hits	466	Shared Neighborhood Hits	29
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

ABI3_HUMAN
NC score	0.069677 (rank : 215)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	204	Target Neighborhood Hits	227	Shared Neighborhood Hits	36
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

PKHA4_MOUSE
NC score	0.069240 (rank : 216)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	204	Target Neighborhood Hits	202	Shared Neighborhood Hits	24
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

ANM2_HUMAN
NC score	0.068749 (rank : 217)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	204	Target Neighborhood Hits	175	Shared Neighborhood Hits	24
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

RBNS5_HUMAN
NC score	0.068641 (rank : 218)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	204	Target Neighborhood Hits	242	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

ANM2_MOUSE
NC score	0.068588 (rank : 219)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	204	Target Neighborhood Hits	175	Shared Neighborhood Hits	24
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

OSTF1_MOUSE
NC score	0.068490 (rank : 220)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	204	Target Neighborhood Hits	467	Shared Neighborhood Hits	30
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

HGS_HUMAN
NC score	0.068074 (rank : 221)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	204	Target Neighborhood Hits	517	Shared Neighborhood Hits	30
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

CF150_HUMAN
NC score	0.068069 (rank : 222)	θ value	0.0113563 (rank : 114)
Query Neighborhood Hits	204	Target Neighborhood Hits	96	Shared Neighborhood Hits	11
SwissProt Accessions	Q8N884, Q32NC9, Q5SWL0, Q5SWL1, Q96E45	Gene names	C6orf150
Domain Architecture	No domain graphic available
Description	Protein C6orf150.

ABI3_MOUSE
NC score	0.067459 (rank : 223)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	204	Target Neighborhood Hits	227	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

PKHA4_HUMAN
NC score	0.066950 (rank : 224)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	204	Target Neighborhood Hits	283	Shared Neighborhood Hits	33
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PLCG1_MOUSE
NC score	0.066454 (rank : 225)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	204	Target Neighborhood Hits	314	Shared Neighborhood Hits	38
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_HUMAN
NC score	0.065763 (rank : 226)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	204	Target Neighborhood Hits	293	Shared Neighborhood Hits	39
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

BCAR1_MOUSE
NC score	0.065404 (rank : 227)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	204	Target Neighborhood Hits	438	Shared Neighborhood Hits	43
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

AHI1_HUMAN
NC score	0.065334 (rank : 228)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	204	Target Neighborhood Hits	537	Shared Neighborhood Hits	37
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

DAPP1_MOUSE
NC score	0.065203 (rank : 229)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	204	Target Neighborhood Hits	225	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

NOXO1_MOUSE
NC score	0.065056 (rank : 230)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	204	Target Neighborhood Hits	114	Shared Neighborhood Hits	20
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

AHI1_MOUSE
NC score	0.064452 (rank : 231)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	204	Target Neighborhood Hits	496	Shared Neighborhood Hits	37
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

DAPP1_HUMAN
NC score	0.063547 (rank : 232)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	204	Target Neighborhood Hits	227	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

RBNS5_MOUSE
NC score	0.063061 (rank : 233)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	204	Target Neighborhood Hits	266	Shared Neighborhood Hits	14
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

DGKH_HUMAN
NC score	0.062427 (rank : 234)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	204	Target Neighborhood Hits	255	Shared Neighborhood Hits	34
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

MYO1F_MOUSE
NC score	0.062192 (rank : 235)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	204	Target Neighborhood Hits	262	Shared Neighborhood Hits	31
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

CIP4_HUMAN
NC score	0.062005 (rank : 236)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	204	Target Neighborhood Hits	374	Shared Neighborhood Hits	17
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

MYO1F_HUMAN
NC score	0.061876 (rank : 237)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	204	Target Neighborhood Hits	275	Shared Neighborhood Hits	33
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

PACN2_HUMAN
NC score	0.060943 (rank : 238)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	204	Target Neighborhood Hits	339	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

FYV1_HUMAN
NC score	0.060426 (rank : 239)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	204	Target Neighborhood Hits	217	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

MYO1E_HUMAN
NC score	0.060188 (rank : 240)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	204	Target Neighborhood Hits	293	Shared Neighborhood Hits	37
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

FYV1_MOUSE
NC score	0.059977 (rank : 241)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	204	Target Neighborhood Hits	191	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

PLCG2_HUMAN
NC score	0.059944 (rank : 242)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	204	Target Neighborhood Hits	280	Shared Neighborhood Hits	31
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

NOXO1_HUMAN
NC score	0.059711 (rank : 243)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	204	Target Neighborhood Hits	100	Shared Neighborhood Hits	20
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

EFS_MOUSE
NC score	0.059031 (rank : 244)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	204	Target Neighborhood Hits	389	Shared Neighborhood Hits	42
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

PDZD8_HUMAN
NC score	0.058461 (rank : 245)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	204	Target Neighborhood Hits	185	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

ZFY19_HUMAN
NC score	0.058136 (rank : 246)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	204	Target Neighborhood Hits	206	Shared Neighborhood Hits	12
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

PACN2_MOUSE
NC score	0.057996 (rank : 247)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	204	Target Neighborhood Hits	382	Shared Neighborhood Hits	34
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

CENA1_HUMAN
NC score	0.057096 (rank : 248)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	204	Target Neighborhood Hits	87	Shared Neighborhood Hits	15
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

IASPP_MOUSE
NC score	0.056973 (rank : 249)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	204	Target Neighborhood Hits	1024	Shared Neighborhood Hits	51
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

PACN1_MOUSE
NC score	0.056581 (rank : 250)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	204	Target Neighborhood Hits	283	Shared Neighborhood Hits	29
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

BCAR1_HUMAN
NC score	0.056567 (rank : 251)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	204	Target Neighborhood Hits	554	Shared Neighborhood Hits	40
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

PKHA1_HUMAN
NC score	0.056555 (rank : 252)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	204	Target Neighborhood Hits	127	Shared Neighborhood Hits	19
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PACN1_HUMAN
NC score	0.055918 (rank : 253)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	204	Target Neighborhood Hits	320	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

EFS_HUMAN
NC score	0.055852 (rank : 254)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	204	Target Neighborhood Hits	348	Shared Neighborhood Hits	38
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

PCTL_MOUSE
NC score	0.055798 (rank : 255)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	204	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JMD3	Gene names	Stard10, Pctpl, Sdccag28, Sdccagg28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28 homolog).

PCTL_HUMAN
NC score	0.055172 (rank : 256)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	204	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y365, O60532	Gene names	STARD10, SDCCAG28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28) (Antigen NY-CO-28).

PKHA5_HUMAN
NC score	0.055170 (rank : 257)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	204	Target Neighborhood Hits	455	Shared Neighborhood Hits	25
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

RUFY2_MOUSE
NC score	0.055067 (rank : 258)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	204	Target Neighborhood Hits	820	Shared Neighborhood Hits	29
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

PACN3_MOUSE
NC score	0.054865 (rank : 259)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	204	Target Neighborhood Hits	380	Shared Neighborhood Hits	30
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

BI2L1_HUMAN
NC score	0.054732 (rank : 260)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	204	Target Neighborhood Hits	156	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

ZFY19_MOUSE
NC score	0.054543 (rank : 261)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	204	Target Neighborhood Hits	143	Shared Neighborhood Hits	13
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

IASPP_HUMAN
NC score	0.054415 (rank : 262)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	204	Target Neighborhood Hits	688	Shared Neighborhood Hits	41
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

SPTA2_HUMAN
NC score	0.054101 (rank : 263)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	204	Target Neighborhood Hits	888	Shared Neighborhood Hits	40
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

CENA2_HUMAN
NC score	0.053969 (rank : 264)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	204	Target Neighborhood Hits	83	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

ZFYV1_HUMAN
NC score	0.053019 (rank : 265)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	204	Target Neighborhood Hits	166	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

DDFL1_HUMAN
NC score	0.052493 (rank : 266)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	204	Target Neighborhood Hits	353	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

CT032_HUMAN
NC score	0.052190 (rank : 267)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	204	Target Neighborhood Hits	235	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

PACN3_HUMAN
NC score	0.052153 (rank : 268)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	204	Target Neighborhood Hits	385	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

SPTA1_MOUSE
NC score	0.052085 (rank : 269)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	204	Target Neighborhood Hits	675	Shared Neighborhood Hits	44
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

ZFYV1_MOUSE
NC score	0.051914 (rank : 270)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	204	Target Neighborhood Hits	153	Shared Neighborhood Hits	12
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

TCRG1_MOUSE
NC score	0.051891 (rank : 271)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	204	Target Neighborhood Hits	947	Shared Neighborhood Hits	29
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

PEX13_MOUSE
NC score	0.051479 (rank : 272)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	204	Target Neighborhood Hits	126	Shared Neighborhood Hits	21
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

RUSC1_MOUSE
NC score	0.051108 (rank : 273)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	204	Target Neighborhood Hits	206	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

TCRG1_HUMAN
NC score	0.051070 (rank : 274)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	204	Target Neighborhood Hits	929	Shared Neighborhood Hits	26
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

PKHA2_MOUSE
NC score	0.050998 (rank : 275)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	204	Target Neighborhood Hits	116	Shared Neighborhood Hits	17
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PEX13_HUMAN
NC score	0.050640 (rank : 276)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	204	Target Neighborhood Hits	128	Shared Neighborhood Hits	23
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PKHA1_MOUSE
NC score	0.050159 (rank : 277)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	204	Target Neighborhood Hits	120	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

DBNL_HUMAN
NC score	0.050079 (rank : 278)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	204	Target Neighborhood Hits	244	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DDFL1_MOUSE
NC score	0.048965 (rank : 279)	θ value	6.88961 (rank : 180)
Query Neighborhood Hits	204	Target Neighborhood Hits	324	Shared Neighborhood Hits	15
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

PCLO_HUMAN
NC score	0.048940 (rank : 280)	θ value	2.36792 (rank : 151)
Query Neighborhood Hits	204	Target Neighborhood Hits	2046	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

ARFG1_MOUSE
NC score	0.048896 (rank : 281)	θ value	4.03905 (rank : 159)
Query Neighborhood Hits	204	Target Neighborhood Hits	51	Shared Neighborhood Hits	8
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

OBSCN_HUMAN
NC score	0.048887 (rank : 282)	θ value	0.279714 (rank : 125)
Query Neighborhood Hits	204	Target Neighborhood Hits	1931	Shared Neighborhood Hits	72
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

PCLO_MOUSE
NC score	0.042087 (rank : 283)	θ value	2.36792 (rank : 152)
Query Neighborhood Hits	204	Target Neighborhood Hits	2275	Shared Neighborhood Hits	70
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

BSN_MOUSE
NC score	0.037248 (rank : 284)	θ value	2.36792 (rank : 147)
Query Neighborhood Hits	204	Target Neighborhood Hits	2057	Shared Neighborhood Hits	50
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

BAT2_HUMAN
NC score	0.035792 (rank : 285)	θ value	5.27518 (rank : 171)
Query Neighborhood Hits	204	Target Neighborhood Hits	931	Shared Neighborhood Hits	37
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

K0528_MOUSE
NC score	0.035383 (rank : 286)	θ value	6.88961 (rank : 182)
Query Neighborhood Hits	204	Target Neighborhood Hits	102	Shared Neighborhood Hits	18
SwissProt Accessions	Q7TPS5, Q3TQY6, Q6A052, Q80VA1, Q8C0U3, Q8CID5, Q9CS85	Gene names	Kiaa0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

K0528_HUMAN
NC score	0.034800 (rank : 287)	θ value	8.99809 (rank : 194)
Query Neighborhood Hits	204	Target Neighborhood Hits	96	Shared Neighborhood Hits	18
SwissProt Accessions	Q86YS7, O60280, Q7Z619, Q86SU3	Gene names	KIAA0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

BAT2_MOUSE
NC score	0.032772 (rank : 288)	θ value	5.27518 (rank : 172)
Query Neighborhood Hits	204	Target Neighborhood Hits	947	Shared Neighborhood Hits	37
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

BSN_HUMAN
NC score	0.032226 (rank : 289)	θ value	6.88961 (rank : 179)
Query Neighborhood Hits	204	Target Neighborhood Hits	1537	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CCD94_MOUSE
NC score	0.028227 (rank : 290)	θ value	4.03905 (rank : 160)
Query Neighborhood Hits	204	Target Neighborhood Hits	127	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D6J3	Gene names	Ccdc94
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 94.

PA24D_MOUSE
NC score	0.027651 (rank : 291)	θ value	1.38821 (rank : 140)
Query Neighborhood Hits	204	Target Neighborhood Hits	100	Shared Neighborhood Hits	18
SwissProt Accessions	Q50L43, Q3TJC5	Gene names	Pla2g4d
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

MLL2_HUMAN
NC score	0.027279 (rank : 292)	θ value	0.279714 (rank : 124)
Query Neighborhood Hits	204	Target Neighborhood Hits	1788	Shared Neighborhood Hits	45
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

GRIN1_HUMAN
NC score	0.026481 (rank : 293)	θ value	0.365318 (rank : 128)
Query Neighborhood Hits	204	Target Neighborhood Hits	681	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

PSL1_HUMAN
NC score	0.025758 (rank : 294)	θ value	0.47712 (rank : 131)
Query Neighborhood Hits	204	Target Neighborhood Hits	650	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

CIC_HUMAN
NC score	0.025320 (rank : 295)	θ value	8.99809 (rank : 190)
Query Neighborhood Hits	204	Target Neighborhood Hits	992	Shared Neighborhood Hits	37
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

CF047_MOUSE
NC score	0.023640 (rank : 296)	θ value	1.06291 (rank : 136)
Query Neighborhood Hits	204	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z1R4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf47 homolog.

NXF2_HUMAN
NC score	0.023132 (rank : 297)	θ value	0.813845 (rank : 133)
Query Neighborhood Hits	204	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	Q9GZY0, Q9BXU4, Q9NSS1, Q9NX66	Gene names	NXF2, TAPL2
Domain Architecture
Description	Nuclear RNA export factor 2 (TAP-like protein 2) (TAPL-2).

CT2NL_HUMAN
NC score	0.022759 (rank : 298)	θ value	4.03905 (rank : 161)
Query Neighborhood Hits	204	Target Neighborhood Hits	1059	Shared Neighborhood Hits	27
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

MUC1_HUMAN
NC score	0.022627 (rank : 299)	θ value	0.125558 (rank : 120)
Query Neighborhood Hits	204	Target Neighborhood Hits	975	Shared Neighborhood Hits	27
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

DYSF_HUMAN
NC score	0.022316 (rank : 300)	θ value	8.99809 (rank : 192)
Query Neighborhood Hits	204	Target Neighborhood Hits	170	Shared Neighborhood Hits	20
SwissProt Accessions	O75923, O75696, Q9UEN7	Gene names	DYSF, FER1L1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

KPCA_HUMAN
NC score	0.020827 (rank : 301)	θ value	1.81305 (rank : 142)
Query Neighborhood Hits	204	Target Neighborhood Hits	1070	Shared Neighborhood Hits	39
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

NXF5_HUMAN
NC score	0.020740 (rank : 302)	θ value	1.38821 (rank : 139)
Query Neighborhood Hits	204	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H1B4, Q9H1B0, Q9H1B1, Q9H1B2, Q9H1B3	Gene names	NXF5, TAPL1
Domain Architecture	No domain graphic available
Description	Nuclear RNA export factor 5 (TAP-like protein 1) (TAPL-1).

DYSF_MOUSE
NC score	0.020659 (rank : 303)	θ value	8.99809 (rank : 193)
Query Neighborhood Hits	204	Target Neighborhood Hits	162	Shared Neighborhood Hits	20
SwissProt Accessions	Q9ESD7, Q9QXC0	Gene names	Dysf, Fer1l1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

SYT1_HUMAN
NC score	0.020432 (rank : 304)	θ value	0.813845 (rank : 134)
Query Neighborhood Hits	204	Target Neighborhood Hits	150	Shared Neighborhood Hits	19
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
NC score	0.020430 (rank : 305)	θ value	0.813845 (rank : 135)
Query Neighborhood Hits	204	Target Neighborhood Hits	150	Shared Neighborhood Hits	19
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

JADE2_MOUSE
NC score	0.020364 (rank : 306)	θ value	3.0926 (rank : 158)
Query Neighborhood Hits	204	Target Neighborhood Hits	560	Shared Neighborhood Hits	23
SwissProt Accessions	Q6ZQF7, Q3UHD5, Q6IE83	Gene names	Phf15, Jade2, Kiaa0239
Domain Architecture	No domain graphic available
Description	Protein Jade-2 (PHD finger protein 15).

NFH_MOUSE
NC score	0.019722 (rank : 307)	θ value	1.81305 (rank : 144)
Query Neighborhood Hits	204	Target Neighborhood Hits	2247	Shared Neighborhood Hits	58
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

BAG3_MOUSE
NC score	0.019281 (rank : 308)	θ value	8.99809 (rank : 188)
Query Neighborhood Hits	204	Target Neighborhood Hits	513	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

SOX13_HUMAN
NC score	0.018906 (rank : 309)	θ value	0.365318 (rank : 129)
Query Neighborhood Hits	204	Target Neighborhood Hits	464	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UN79, O95275, O95826, Q9UHW7	Gene names	SOX13
Domain Architecture
Description	SOX-13 protein (Type 1 diabetes autoantigen ICA12) (Islet cell antigen 12).

KPCA_MOUSE
NC score	0.018835 (rank : 310)	θ value	6.88961 (rank : 183)
Query Neighborhood Hits	204	Target Neighborhood Hits	1067	Shared Neighborhood Hits	39
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

SOX13_MOUSE
NC score	0.017926 (rank : 311)	θ value	4.03905 (rank : 167)
Query Neighborhood Hits	204	Target Neighborhood Hits	495	Shared Neighborhood Hits	21
SwissProt Accessions	Q04891, Q922L3	Gene names	Sox13, Sox-13
Domain Architecture
Description	SOX-13 protein.

NEURL_MOUSE
NC score	0.016944 (rank : 312)	θ value	2.36792 (rank : 150)
Query Neighborhood Hits	204	Target Neighborhood Hits	106	Shared Neighborhood Hits	5
SwissProt Accessions	Q923S6, Q91ZT6, Q9CWF1, Q9QWF1	Gene names	Neurl, Neurl1
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (m-neuralized 1) (m-neu1).

PA24F_HUMAN
NC score	0.016208 (rank : 313)	θ value	4.03905 (rank : 164)
Query Neighborhood Hits	204	Target Neighborhood Hits	78	Shared Neighborhood Hits	15
SwissProt Accessions	Q68DD2, Q6ZMC8	Gene names	PLA2G4F
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

K0179_HUMAN
NC score	0.015551 (rank : 314)	θ value	2.36792 (rank : 149)
Query Neighborhood Hits	204	Target Neighborhood Hits	81	Shared Neighborhood Hits	6
SwissProt Accessions	Q14684, Q8TBZ4	Gene names	KIAA0179
Domain Architecture
Description	Protein KIAA0179.

PRC1_HUMAN
NC score	0.015029 (rank : 315)	θ value	4.03905 (rank : 166)
Query Neighborhood Hits	204	Target Neighborhood Hits	328	Shared Neighborhood Hits	11
SwissProt Accessions	O43663, Q9BSB6	Gene names	PRC1
Domain Architecture	No domain graphic available
Description	Protein regulator of cytokinesis 1.

NEUL1_HUMAN
NC score	0.014718 (rank : 316)	θ value	5.27518 (rank : 174)
Query Neighborhood Hits	204	Target Neighborhood Hits	114	Shared Neighborhood Hits	6
SwissProt Accessions	O76050, Q5TDR2, Q5TDR3, Q8TAN0, Q9H463	Gene names	NEURL, NEURL1, RNF67
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (h-neuralized 1) (h-neu) (RING finger protein 67).

MO4L2_HUMAN
NC score	0.013288 (rank : 317)	θ value	1.81305 (rank : 143)
Query Neighborhood Hits	204	Target Neighborhood Hits	90	Shared Neighborhood Hits	6
SwissProt Accessions	Q15014, Q567V0, Q8J026	Gene names	MORF4L2, KIAA0026, MRGX
Domain Architecture
Description	Mortality factor 4-like protein 2 (MORF-related gene X protein) (Transcription factor-like protein MRGX) (MSL3-2 protein).

LRSM1_HUMAN
NC score	0.012605 (rank : 318)	θ value	4.03905 (rank : 163)
Query Neighborhood Hits	204	Target Neighborhood Hits	1078	Shared Neighborhood Hits	28
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

LRP6_MOUSE
NC score	0.012308 (rank : 319)	θ value	0.279714 (rank : 123)
Query Neighborhood Hits	204	Target Neighborhood Hits	232	Shared Neighborhood Hits	3
SwissProt Accessions	O88572	Gene names	Lrp6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

LRP6_HUMAN
NC score	0.012265 (rank : 320)	θ value	0.279714 (rank : 122)
Query Neighborhood Hits	204	Target Neighborhood Hits	235	Shared Neighborhood Hits	3
SwissProt Accessions	O75581	Gene names	LRP6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

NTKL_HUMAN
NC score	0.011116 (rank : 321)	θ value	5.27518 (rank : 175)
Query Neighborhood Hits	204	Target Neighborhood Hits	266	Shared Neighborhood Hits	10
SwissProt Accessions	Q96KG9, Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53	Gene names	SCYL1, GKLP, NTKL, TAPK, TEIF, TRAP
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (Teratoma- associated tyrosine kinase) (Telomerase transcriptional element- interacting factor) (Telomerase regulation-associated protein).

HSN2_MOUSE
NC score	0.010939 (rank : 322)	θ value	6.88961 (rank : 181)
Query Neighborhood Hits	204	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q6IFS6	Gene names	Hsn2
Domain Architecture	No domain graphic available
Description	Protein HSN2 precursor.

SRCH_HUMAN
NC score	0.010713 (rank : 323)	θ value	8.99809 (rank : 201)
Query Neighborhood Hits	204	Target Neighborhood Hits	225	Shared Neighborhood Hits	9
SwissProt Accessions	P23327, Q504Y6	Gene names	HRC, HCP
Domain Architecture	No domain graphic available
Description	Sarcoplasmic reticulum histidine-rich calcium-binding protein precursor.

NTKL_MOUSE
NC score	0.009312 (rank : 324)	θ value	5.27518 (rank : 176)
Query Neighborhood Hits	204	Target Neighborhood Hits	326	Shared Neighborhood Hits	9
SwissProt Accessions	Q9EQC5, Q3TST7, Q3UKU0, Q8K222	Gene names	Scyl1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (105 kDa kinase- like protein) (Mitosis-associated kinase-like protein NTKL).

B3A3_MOUSE
NC score	0.009284 (rank : 325)	θ value	2.36792 (rank : 146)
Query Neighborhood Hits	204	Target Neighborhood Hits	112	Shared Neighborhood Hits	11
SwissProt Accessions	P16283	Gene names	Slc4a3, Ae3
Domain Architecture
Description	Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3).

OXRP_HUMAN
NC score	0.009128 (rank : 326)	θ value	1.06291 (rank : 137)
Query Neighborhood Hits	204	Target Neighborhood Hits	544	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y4L1	Gene names	HYOU1, ORP150
Domain Architecture
Description	150 kDa oxygen-regulated protein precursor (Orp150) (Hypoxia up- regulated 1).

SSH2_MOUSE
NC score	0.008689 (rank : 327)	θ value	1.06291 (rank : 138)
Query Neighborhood Hits	204	Target Neighborhood Hits	119	Shared Neighborhood Hits	5
SwissProt Accessions	Q5SW75, Q3TDK8, Q3TYP8, Q3U2K3, Q5F268, Q5SW74, Q69ZC3, Q76I78	Gene names	Ssh2, Kiaa1725, Ssh2l
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-2L) (mSSH-2L).

FBX41_HUMAN
NC score	0.008231 (rank : 328)	θ value	3.0926 (rank : 157)
Query Neighborhood Hits	204	Target Neighborhood Hits	475	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TF61	Gene names	FBXO41, FBX41, KIAA1940
Domain Architecture	No domain graphic available
Description	F-box only protein 41.

ADIP_MOUSE
NC score	0.007810 (rank : 329)	θ value	8.99809 (rank : 187)
Query Neighborhood Hits	204	Target Neighborhood Hits	415	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VC66, Q8BG59, Q8C7X0, Q8K2F7	Gene names	Ssx2ip
Domain Architecture	No domain graphic available
Description	Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain- interacting protein).

B3A3_HUMAN
NC score	0.007752 (rank : 330)	θ value	5.27518 (rank : 170)
Query Neighborhood Hits	204	Target Neighborhood Hits	119	Shared Neighborhood Hits	10
SwissProt Accessions	P48751	Gene names	SLC4A3, AE3
Domain Architecture
Description	Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3).

REXO4_MOUSE
NC score	0.007689 (rank : 331)	θ value	8.99809 (rank : 199)
Query Neighborhood Hits	204	Target Neighborhood Hits	42	Shared Neighborhood Hits	6
SwissProt Accessions	Q6PAQ4, Q3UU17, Q8C524	Gene names	Rexo4, Gm111, Pmc2, Xpmc2h
Domain Architecture	No domain graphic available
Description	RNA exonuclease 4 (EC 3.1.-.-) (Exonuclease XPMC2) (Prevents mitotic catastrophe 2 protein homolog).

CABYR_MOUSE
NC score	0.007283 (rank : 332)	θ value	8.99809 (rank : 189)
Query Neighborhood Hits	204	Target Neighborhood Hits	80	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D424, Q91Y41, Q91Y42	Gene names	Cabyr, Cbp86
Domain Architecture	No domain graphic available
Description	Calcium-binding tyrosine phosphorylation-regulated protein (Calcium- binding protein 86) (Testis-specific calcium-binding protein CBP86).

YTDC1_HUMAN
NC score	0.006433 (rank : 333)	θ value	8.99809 (rank : 202)
Query Neighborhood Hits	204	Target Neighborhood Hits	458	Shared Neighborhood Hits	9
SwissProt Accessions	Q96MU7, Q7Z622, Q8TF35	Gene names	YTHDC1, KIAA1966, YT521
Domain Architecture
Description	YTH domain-containing protein 1 (Putative splicing factor YT521).

ANK2_HUMAN
NC score	0.006367 (rank : 334)	θ value	5.27518 (rank : 169)
Query Neighborhood Hits	204	Target Neighborhood Hits	1615	Shared Neighborhood Hits	45
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

PITM1_HUMAN
NC score	0.005688 (rank : 335)	θ value	5.27518 (rank : 177)
Query Neighborhood Hits	204	Target Neighborhood Hits	129	Shared Neighborhood Hits	8
SwissProt Accessions	O00562, Q6T7X3, Q8TBN3, Q9BZ73	Gene names	PITPNM1, DRES9, NIR2, PITPNM
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 1 (Phosphatidylinositol transfer protein, membrane-associated 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) (Drosophila retinal degeneration B homolog).

DHX57_HUMAN
NC score	0.004360 (rank : 336)	θ value	3.0926 (rank : 156)
Query Neighborhood Hits	204	Target Neighborhood Hits	109	Shared Neighborhood Hits	2
SwissProt Accessions	Q6P158, Q53SI4, Q6P9G1, Q7Z6H3, Q8NG17, Q96M33	Gene names	DHX57
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX57 (EC 3.6.1.-) (DEAH box protein 57).

DYH5_HUMAN
NC score	0.003854 (rank : 337)	θ value	8.99809 (rank : 191)
Query Neighborhood Hits	204	Target Neighborhood Hits	323	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TE73, Q92860, Q96L74, Q9H5S7, Q9HCG9	Gene names	DNAH5, DNAHC5, KIAA1603
Domain Architecture	No domain graphic available
Description	Ciliary dynein heavy chain 5 (Axonemal beta dynein heavy chain 5) (HL1).

PINK1_HUMAN
NC score	0.003614 (rank : 338)	θ value	2.36792 (rank : 153)
Query Neighborhood Hits	204	Target Neighborhood Hits	741	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

CAC1F_HUMAN
NC score	0.003252 (rank : 339)	θ value	2.36792 (rank : 148)
Query Neighborhood Hits	204	Target Neighborhood Hits	141	Shared Neighborhood Hits	4
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

NOS3_MOUSE
NC score	0.003155 (rank : 340)	θ value	8.99809 (rank : 196)
Query Neighborhood Hits	204	Target Neighborhood Hits	63	Shared Neighborhood Hits	5
SwissProt Accessions	P70313, O55056	Gene names	Nos3, Ecnos
Domain Architecture
Description	Nitric-oxide synthase, endothelial (EC 1.14.13.39) (EC-NOS) (NOS type III) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS).

TBX2_HUMAN
NC score	0.002883 (rank : 341)	θ value	6.88961 (rank : 185)
Query Neighborhood Hits	204	Target Neighborhood Hits	195	Shared Neighborhood Hits	9
SwissProt Accessions	Q13207, Q16424, Q7Z647	Gene names	TBX2
Domain Architecture
Description	T-box transcription factor TBX2 (T-box protein 2).

RN168_HUMAN
NC score	0.002793 (rank : 342)	θ value	8.99809 (rank : 200)
Query Neighborhood Hits	204	Target Neighborhood Hits	370	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IYW5, Q8NA67, Q96NS4	Gene names	RNF168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

ZO1_HUMAN
NC score	0.001662 (rank : 343)	θ value	8.99809 (rank : 204)
Query Neighborhood Hits	204	Target Neighborhood Hits	474	Shared Neighborhood Hits	12
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

MICA3_HUMAN
NC score	0.000705 (rank : 344)	θ value	8.99809 (rank : 195)
Query Neighborhood Hits	204	Target Neighborhood Hits	160	Shared Neighborhood Hits	4
SwissProt Accessions	Q7RTP6, Q6ICK4, Q9P2I3	Gene names	MICAL3, KIAA1364
Domain Architecture
Description	Protein MICAL-3.

NUCL_MOUSE
NC score	0.000527 (rank : 345)	θ value	8.99809 (rank : 197)
Query Neighborhood Hits	204	Target Neighborhood Hits	425	Shared Neighborhood Hits	8
SwissProt Accessions	P09405, Q548M9, Q61991, Q99K50	Gene names	Ncl, Nuc
Domain Architecture
Description	Nucleolin (Protein C23).

PZRN3_MOUSE
NC score	-0.000264 (rank : 346)	θ value	8.99809 (rank : 198)
Query Neighborhood Hits	204	Target Neighborhood Hits	447	Shared Neighborhood Hits	7
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

FOG1_MOUSE
NC score	-0.000747 (rank : 347)	θ value	5.27518 (rank : 173)
Query Neighborhood Hits	204	Target Neighborhood Hits	1237	Shared Neighborhood Hits	31
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

HXC11_HUMAN
NC score	-0.001563 (rank : 348)	θ value	4.03905 (rank : 162)
Query Neighborhood Hits	204	Target Neighborhood Hits	349	Shared Neighborhood Hits	4
SwissProt Accessions	O43248, Q96DH2	Gene names	HOXC11
Domain Architecture
Description	Homeobox protein Hox-C11.

ZN142_HUMAN
NC score	-0.004194 (rank : 349)	θ value	0.279714 (rank : 126)
Query Neighborhood Hits	204	Target Neighborhood Hits	1007	Shared Neighborhood Hits	20
SwissProt Accessions	P52746, Q92510	Gene names	ZNF142, KIAA0236
Domain Architecture	No domain graphic available
Description	Zinc finger protein 142 (HA4654).

MK04_MOUSE
NC score	-0.004669 (rank : 350)	θ value	6.88961 (rank : 184)
Query Neighborhood Hits	204	Target Neighborhood Hits	852	Shared Neighborhood Hits	10
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

TCF8_MOUSE
NC score	-0.005368 (rank : 351)	θ value	4.03905 (rank : 168)
Query Neighborhood Hits	204	Target Neighborhood Hits	1067	Shared Neighborhood Hits	23
SwissProt Accessions	Q64318, Q62519	Gene names	Tcf8, Zfhx1a, Zfx1a, Zfx1ha
Domain Architecture
Description	Transcription factor 8 (Zinc finger homeobox protein 1a) (MEB1) (Delta EF1).

ZN263_HUMAN
NC score	-0.006993 (rank : 352)	θ value	6.88961 (rank : 186)
Query Neighborhood Hits	204	Target Neighborhood Hits	795	Shared Neighborhood Hits	11
SwissProt Accessions	O14978, O43387, Q96H95	Gene names	ZNF263, FPM315
Domain Architecture
Description	Zinc finger protein 263 (Zinc finger protein FPM315).

ZN445_HUMAN
NC score	-0.007513 (rank : 353)	θ value	8.99809 (rank : 203)
Query Neighborhood Hits	204	Target Neighborhood Hits	764	Shared Neighborhood Hits	7
SwissProt Accessions	P59923	Gene names	ZNF445, ZNF168
Domain Architecture
Description	Zinc finger protein 445.