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Network neighborhood for query Sequence : PKHG1_HUMAN

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PKHG1_HUMAN
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PKHG1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	174	Target Neighborhood Hits	174	Shared Neighborhood Hits	174
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

MCF2L_MOUSE
θ value	1.37539e-32 (rank : 2)	NC score	0.780043 (rank : 8)
Query Neighborhood Hits	174	Target Neighborhood Hits	255	Shared Neighborhood Hits	72
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	5.22648e-32 (rank : 3)	NC score	0.821304 (rank : 4)
Query Neighborhood Hits	174	Target Neighborhood Hits	166	Shared Neighborhood Hits	70
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

TRIO_HUMAN
θ value	2.59387e-31 (rank : 4)	NC score	0.276150 (rank : 74)
Query Neighborhood Hits	174	Target Neighborhood Hits	1580	Shared Neighborhood Hits	87
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

ARHG9_HUMAN
θ value	1.6813e-30 (rank : 5)	NC score	0.807039 (rank : 5)
Query Neighborhood Hits	174	Target Neighborhood Hits	235	Shared Neighborhood Hits	71
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	1.6813e-30 (rank : 6)	NC score	0.806953 (rank : 6)
Query Neighborhood Hits	174	Target Neighborhood Hits	234	Shared Neighborhood Hits	71
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

HAPIP_HUMAN
θ value	1.4233e-29 (rank : 7)	NC score	0.670494 (rank : 19)
Query Neighborhood Hits	174	Target Neighborhood Hits	350	Shared Neighborhood Hits	75
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

PKHG4_HUMAN
θ value	1.57365e-28 (rank : 8)	NC score	0.713698 (rank : 13)
Query Neighborhood Hits	174	Target Neighborhood Hits	200	Shared Neighborhood Hits	60
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

ARHG4_MOUSE
θ value	3.50572e-28 (rank : 9)	NC score	0.829107 (rank : 2)
Query Neighborhood Hits	174	Target Neighborhood Hits	185	Shared Neighborhood Hits	69
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PREX1_HUMAN
θ value	1.02001e-27 (rank : 10)	NC score	0.827750 (rank : 3)
Query Neighborhood Hits	174	Target Neighborhood Hits	177	Shared Neighborhood Hits	73
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ARHG7_MOUSE
θ value	2.96777e-27 (rank : 11)	NC score	0.652984 (rank : 25)
Query Neighborhood Hits	174	Target Neighborhood Hits	396	Shared Neighborhood Hits	71
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG4_HUMAN
θ value	5.06226e-27 (rank : 12)	NC score	0.797612 (rank : 7)
Query Neighborhood Hits	174	Target Neighborhood Hits	242	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG7_HUMAN
θ value	4.28545e-26 (rank : 13)	NC score	0.653839 (rank : 24)
Query Neighborhood Hits	174	Target Neighborhood Hits	347	Shared Neighborhood Hits	70
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

DUET_HUMAN
θ value	9.54697e-26 (rank : 14)	NC score	0.268924 (rank : 75)
Query Neighborhood Hits	174	Target Neighborhood Hits	1220	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

ARHG6_HUMAN
θ value	3.62785e-25 (rank : 15)	NC score	0.631240 (rank : 32)
Query Neighborhood Hits	174	Target Neighborhood Hits	376	Shared Neighborhood Hits	66
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

TIAM1_MOUSE
θ value	4.01107e-24 (rank : 16)	NC score	0.760973 (rank : 9)
Query Neighborhood Hits	174	Target Neighborhood Hits	205	Shared Neighborhood Hits	68
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG6_MOUSE
θ value	8.93572e-24 (rank : 17)	NC score	0.610553 (rank : 34)
Query Neighborhood Hits	174	Target Neighborhood Hits	394	Shared Neighborhood Hits	67
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

TIAM1_HUMAN
θ value	1.16704e-23 (rank : 18)	NC score	0.754246 (rank : 10)
Query Neighborhood Hits	174	Target Neighborhood Hits	225	Shared Neighborhood Hits	69
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

VAV_MOUSE
θ value	1.5242e-23 (rank : 19)	NC score	0.590635 (rank : 40)
Query Neighborhood Hits	174	Target Neighborhood Hits	430	Shared Neighborhood Hits	68
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV2_MOUSE
θ value	1.42661e-21 (rank : 20)	NC score	0.589331 (rank : 41)
Query Neighborhood Hits	174	Target Neighborhood Hits	456	Shared Neighborhood Hits	70
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV2_HUMAN
θ value	3.17815e-21 (rank : 21)	NC score	0.583724 (rank : 43)
Query Neighborhood Hits	174	Target Neighborhood Hits	453	Shared Neighborhood Hits	69
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV_HUMAN
θ value	4.15078e-21 (rank : 22)	NC score	0.579380 (rank : 46)
Query Neighborhood Hits	174	Target Neighborhood Hits	452	Shared Neighborhood Hits	68
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV3_HUMAN
θ value	3.51386e-20 (rank : 23)	NC score	0.582019 (rank : 45)
Query Neighborhood Hits	174	Target Neighborhood Hits	398	Shared Neighborhood Hits	68
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	3.51386e-20 (rank : 24)	NC score	0.583535 (rank : 44)
Query Neighborhood Hits	174	Target Neighborhood Hits	404	Shared Neighborhood Hits	69
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

FGD6_HUMAN
θ value	3.63628e-17 (rank : 25)	NC score	0.599835 (rank : 38)
Query Neighborhood Hits	174	Target Neighborhood Hits	237	Shared Neighborhood Hits	66
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	6.20254e-17 (rank : 26)	NC score	0.607021 (rank : 37)
Query Neighborhood Hits	174	Target Neighborhood Hits	282	Shared Neighborhood Hits	66
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD3_MOUSE
θ value	1.058e-16 (rank : 27)	NC score	0.719060 (rank : 12)
Query Neighborhood Hits	174	Target Neighborhood Hits	257	Shared Neighborhood Hits	74
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD5_MOUSE
θ value	1.058e-16 (rank : 28)	NC score	0.488348 (rank : 56)
Query Neighborhood Hits	174	Target Neighborhood Hits	170	Shared Neighborhood Hits	52
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

OBSCN_HUMAN
θ value	4.02038e-16 (rank : 29)	NC score	0.143354 (rank : 101)
Query Neighborhood Hits	174	Target Neighborhood Hits	1931	Shared Neighborhood Hits	72
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

FARP2_HUMAN
θ value	1.16975e-15 (rank : 30)	NC score	0.484203 (rank : 57)
Query Neighborhood Hits	174	Target Neighborhood Hits	240	Shared Neighborhood Hits	71
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FGD4_MOUSE
θ value	1.52774e-15 (rank : 31)	NC score	0.695004 (rank : 15)
Query Neighborhood Hits	174	Target Neighborhood Hits	227	Shared Neighborhood Hits	71
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD3_HUMAN
θ value	3.40345e-15 (rank : 32)	NC score	0.692447 (rank : 16)
Query Neighborhood Hits	174	Target Neighborhood Hits	249	Shared Neighborhood Hits	72
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

DNMBP_MOUSE
θ value	4.44505e-15 (rank : 33)	NC score	0.588928 (rank : 42)
Query Neighborhood Hits	174	Target Neighborhood Hits	435	Shared Neighborhood Hits	71
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_HUMAN
θ value	7.58209e-15 (rank : 34)	NC score	0.576718 (rank : 47)
Query Neighborhood Hits	174	Target Neighborhood Hits	413	Shared Neighborhood Hits	71
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

FGD5_HUMAN
θ value	7.58209e-15 (rank : 35)	NC score	0.504169 (rank : 52)
Query Neighborhood Hits	174	Target Neighborhood Hits	235	Shared Neighborhood Hits	49
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FARP2_MOUSE
θ value	1.29331e-14 (rank : 36)	NC score	0.504905 (rank : 51)
Query Neighborhood Hits	174	Target Neighborhood Hits	209	Shared Neighborhood Hits	72
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FGD4_HUMAN
θ value	2.88119e-14 (rank : 37)	NC score	0.692430 (rank : 17)
Query Neighborhood Hits	174	Target Neighborhood Hits	219	Shared Neighborhood Hits	71
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

ITSN2_HUMAN
θ value	1.09485e-13 (rank : 38)	NC score	0.459944 (rank : 59)
Query Neighborhood Hits	174	Target Neighborhood Hits	1173	Shared Neighborhood Hits	83
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ECT2_MOUSE
θ value	1.58096e-12 (rank : 39)	NC score	0.719666 (rank : 11)
Query Neighborhood Hits	174	Target Neighborhood Hits	98	Shared Neighborhood Hits	72
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_HUMAN
θ value	2.0648e-12 (rank : 40)	NC score	0.705659 (rank : 14)
Query Neighborhood Hits	174	Target Neighborhood Hits	98	Shared Neighborhood Hits	71
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHG8_HUMAN
θ value	6.00763e-12 (rank : 41)	NC score	0.666841 (rank : 20)
Query Neighborhood Hits	174	Target Neighborhood Hits	85	Shared Neighborhood Hits	65
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

FGD2_HUMAN
θ value	6.00763e-12 (rank : 42)	NC score	0.681396 (rank : 18)
Query Neighborhood Hits	174	Target Neighborhood Hits	151	Shared Neighborhood Hits	71
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

ITSN1_HUMAN
θ value	7.84624e-12 (rank : 43)	NC score	0.421694 (rank : 65)
Query Neighborhood Hits	174	Target Neighborhood Hits	1757	Shared Neighborhood Hits	96
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	1.33837e-11 (rank : 44)	NC score	0.421002 (rank : 66)
Query Neighborhood Hits	174	Target Neighborhood Hits	1669	Shared Neighborhood Hits	102
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ARHGG_HUMAN
θ value	2.28291e-11 (rank : 45)	NC score	0.636236 (rank : 31)
Query Neighborhood Hits	174	Target Neighborhood Hits	129	Shared Neighborhood Hits	67
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

FGD1_MOUSE
θ value	6.64225e-11 (rank : 46)	NC score	0.639697 (rank : 28)
Query Neighborhood Hits	174	Target Neighborhood Hits	387	Shared Neighborhood Hits	70
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

SOS1_HUMAN
θ value	8.67504e-11 (rank : 47)	NC score	0.369424 (rank : 71)
Query Neighborhood Hits	174	Target Neighborhood Hits	274	Shared Neighborhood Hits	44
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

ARHGA_HUMAN
θ value	1.133e-10 (rank : 48)	NC score	0.637444 (rank : 30)
Query Neighborhood Hits	174	Target Neighborhood Hits	187	Shared Neighborhood Hits	68
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

NGEF_MOUSE
θ value	1.133e-10 (rank : 49)	NC score	0.598989 (rank : 39)
Query Neighborhood Hits	174	Target Neighborhood Hits	228	Shared Neighborhood Hits	72
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHG3_HUMAN
θ value	1.9326e-10 (rank : 50)	NC score	0.665435 (rank : 21)
Query Neighborhood Hits	174	Target Neighborhood Hits	82	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

SOS1_MOUSE
θ value	1.9326e-10 (rank : 51)	NC score	0.353841 (rank : 72)
Query Neighborhood Hits	174	Target Neighborhood Hits	281	Shared Neighborhood Hits	45
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

ARHGG_MOUSE
θ value	2.52405e-10 (rank : 52)	NC score	0.628141 (rank : 33)
Query Neighborhood Hits	174	Target Neighborhood Hits	152	Shared Neighborhood Hits	65
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ITSN2_MOUSE
θ value	2.52405e-10 (rank : 53)	NC score	0.434503 (rank : 63)
Query Neighborhood Hits	174	Target Neighborhood Hits	1371	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

NGEF_HUMAN
θ value	2.52405e-10 (rank : 54)	NC score	0.608380 (rank : 35)
Query Neighborhood Hits	174	Target Neighborhood Hits	166	Shared Neighborhood Hits	68
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHG8_MOUSE
θ value	3.29651e-10 (rank : 55)	NC score	0.652319 (rank : 26)
Query Neighborhood Hits	174	Target Neighborhood Hits	79	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

FGD1_HUMAN
θ value	3.29651e-10 (rank : 56)	NC score	0.641477 (rank : 27)
Query Neighborhood Hits	174	Target Neighborhood Hits	367	Shared Neighborhood Hits	74
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ARHGB_HUMAN
θ value	1.63604e-09 (rank : 57)	NC score	0.531266 (rank : 50)
Query Neighborhood Hits	174	Target Neighborhood Hits	375	Shared Neighborhood Hits	72
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGA_MOUSE
θ value	2.13673e-09 (rank : 58)	NC score	0.638874 (rank : 29)
Query Neighborhood Hits	174	Target Neighborhood Hits	125	Shared Neighborhood Hits	64
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

FGD2_MOUSE
θ value	2.79066e-09 (rank : 59)	NC score	0.663337 (rank : 22)
Query Neighborhood Hits	174	Target Neighborhood Hits	163	Shared Neighborhood Hits	70
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

SOS2_HUMAN
θ value	3.64472e-09 (rank : 60)	NC score	0.335330 (rank : 73)
Query Neighborhood Hits	174	Target Neighborhood Hits	193	Shared Neighborhood Hits	38
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

ARHG3_MOUSE
θ value	6.21693e-09 (rank : 61)	NC score	0.662472 (rank : 23)
Query Neighborhood Hits	174	Target Neighborhood Hits	85	Shared Neighborhood Hits	64
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG1_HUMAN
θ value	8.97725e-08 (rank : 62)	NC score	0.543788 (rank : 48)
Query Neighborhood Hits	174	Target Neighborhood Hits	176	Shared Neighborhood Hits	62
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	1.99992e-07 (rank : 63)	NC score	0.497172 (rank : 54)
Query Neighborhood Hits	174	Target Neighborhood Hits	266	Shared Neighborhood Hits	59
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ABR_HUMAN
θ value	2.61198e-07 (rank : 64)	NC score	0.396202 (rank : 69)
Query Neighborhood Hits	174	Target Neighborhood Hits	166	Shared Neighborhood Hits	63
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

FARP1_HUMAN
θ value	5.81887e-07 (rank : 65)	NC score	0.424123 (rank : 64)
Query Neighborhood Hits	174	Target Neighborhood Hits	241	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

ARHGC_HUMAN
θ value	9.92553e-07 (rank : 66)	NC score	0.501372 (rank : 53)
Query Neighborhood Hits	174	Target Neighborhood Hits	351	Shared Neighborhood Hits	74
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGF_HUMAN
θ value	3.77169e-06 (rank : 67)	NC score	0.534642 (rank : 49)
Query Neighborhood Hits	174	Target Neighborhood Hits	214	Shared Neighborhood Hits	68
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

BCR_HUMAN
θ value	4.92598e-06 (rank : 68)	NC score	0.390750 (rank : 70)
Query Neighborhood Hits	174	Target Neighborhood Hits	204	Shared Neighborhood Hits	62
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ARHG5_HUMAN
θ value	1.43324e-05 (rank : 69)	NC score	0.607299 (rank : 36)
Query Neighborhood Hits	174	Target Neighborhood Hits	172	Shared Neighborhood Hits	68
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG2_MOUSE
θ value	0.000786445 (rank : 70)	NC score	0.496628 (rank : 55)
Query Neighborhood Hits	174	Target Neighborhood Hits	120	Shared Neighborhood Hits	62
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

RGNEF_MOUSE
θ value	0.00298849 (rank : 71)	NC score	0.415776 (rank : 67)
Query Neighborhood Hits	174	Target Neighborhood Hits	641	Shared Neighborhood Hits	71
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

DSPP_MOUSE
θ value	0.00665767 (rank : 72)	NC score	0.057351 (rank : 241)
Query Neighborhood Hits	174	Target Neighborhood Hits	491	Shared Neighborhood Hits	23
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

DMP1_MOUSE
θ value	0.0431538 (rank : 73)	NC score	0.048509 (rank : 267)
Query Neighborhood Hits	174	Target Neighborhood Hits	498	Shared Neighborhood Hits	19
SwissProt Accessions	O55188	Gene names	Dmp1, Dmp
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1) (AG1).

DSPP_HUMAN
θ value	0.0431538 (rank : 74)	NC score	0.044988 (rank : 269)
Query Neighborhood Hits	174	Target Neighborhood Hits	645	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

TARA_HUMAN
θ value	0.0431538 (rank : 75)	NC score	0.050974 (rank : 262)
Query Neighborhood Hits	174	Target Neighborhood Hits	1626	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

ARHG2_HUMAN
θ value	0.0563607 (rank : 76)	NC score	0.455496 (rank : 61)
Query Neighborhood Hits	174	Target Neighborhood Hits	142	Shared Neighborhood Hits	60
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

RSU1_HUMAN
θ value	0.0736092 (rank : 77)	NC score	0.016138 (rank : 323)
Query Neighborhood Hits	174	Target Neighborhood Hits	250	Shared Neighborhood Hits	3
SwissProt Accessions	Q15404	Gene names	RSU1, RSP1
Domain Architecture
Description	Ras suppressor protein 1 (Rsu-1) (RSP-1).

FA13A_MOUSE
θ value	0.0961366 (rank : 78)	NC score	0.032877 (rank : 277)
Query Neighborhood Hits	174	Target Neighborhood Hits	83	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BGI4, Q8BZ91	Gene names	Fam13a1, Precm1
Domain Architecture	No domain graphic available
Description	Protein FAM13A1 (Precm1 protein).

RSU1_MOUSE
θ value	0.125558 (rank : 79)	NC score	0.016435 (rank : 322)
Query Neighborhood Hits	174	Target Neighborhood Hits	239	Shared Neighborhood Hits	3
SwissProt Accessions	Q01730	Gene names	Rsu1, Rsp1
Domain Architecture	No domain graphic available
Description	Ras suppressor protein 1 (Rsu-1) (RSP-1).

CT2NL_MOUSE
θ value	0.163984 (rank : 80)	NC score	0.034706 (rank : 274)
Query Neighborhood Hits	174	Target Neighborhood Hits	902	Shared Neighborhood Hits	27
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

AF9_HUMAN
θ value	0.21417 (rank : 81)	NC score	0.035649 (rank : 273)
Query Neighborhood Hits	174	Target Neighborhood Hits	202	Shared Neighborhood Hits	11
SwissProt Accessions	P42568	Gene names	MLLT3, AF9, YEATS3
Domain Architecture
Description	Protein AF-9 (ALL1 fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3).

DMP1_HUMAN
θ value	0.21417 (rank : 82)	NC score	0.048067 (rank : 268)
Query Neighborhood Hits	174	Target Neighborhood Hits	491	Shared Neighborhood Hits	23
SwissProt Accessions	Q13316, O43265	Gene names	DMP1
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1).

LAMA2_HUMAN
θ value	0.21417 (rank : 83)	NC score	0.008721 (rank : 350)
Query Neighborhood Hits	174	Target Neighborhood Hits	1092	Shared Neighborhood Hits	14
SwissProt Accessions	P24043, Q14736, Q93022	Gene names	LAMA2, LAMM
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

APC_MOUSE
θ value	0.279714 (rank : 84)	NC score	0.037144 (rank : 272)
Query Neighborhood Hits	174	Target Neighborhood Hits	441	Shared Neighborhood Hits	20
SwissProt Accessions	Q61315, Q62044	Gene names	Apc
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC) (mAPC).

MAST1_HUMAN
θ value	0.279714 (rank : 85)	NC score	0.015239 (rank : 329)
Query Neighborhood Hits	174	Target Neighborhood Hits	1146	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

AKAP9_HUMAN
θ value	0.365318 (rank : 86)	NC score	0.031267 (rank : 283)
Query Neighborhood Hits	174	Target Neighborhood Hits	1710	Shared Neighborhood Hits	48
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

GNAI2_HUMAN
θ value	0.365318 (rank : 87)	NC score	0.010452 (rank : 344)
Query Neighborhood Hits	174	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	P04899, Q8IZ71	Gene names	GNAI2
Domain Architecture
Description	Guanine nucleotide-binding protein G(i), alpha-2 subunit (Adenylate cyclase-inhibiting G alpha protein).

CHD9_MOUSE
θ value	0.47712 (rank : 88)	NC score	0.012824 (rank : 336)
Query Neighborhood Hits	174	Target Neighborhood Hits	427	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BYH8, Q7TMV5, Q8BJG8, Q8BZJ2, Q8CHG8	Gene names	Chd9, Kiaa0308, Pric320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha- interacting complex protein 320 kDa).

SEP10_HUMAN
θ value	0.47712 (rank : 89)	NC score	0.028218 (rank : 288)
Query Neighborhood Hits	174	Target Neighborhood Hits	161	Shared Neighborhood Hits	13
SwissProt Accessions	Q9P0V9, Q9HAH6	Gene names	SEPT10
Domain Architecture	No domain graphic available
Description	Septin-10.

SEP10_MOUSE
θ value	0.47712 (rank : 90)	NC score	0.030340 (rank : 285)
Query Neighborhood Hits	174	Target Neighborhood Hits	145	Shared Neighborhood Hits	13
SwissProt Accessions	Q8C650, Q7TSA5	Gene names	Sept10
Domain Architecture	No domain graphic available
Description	Septin-10.

SI1L1_MOUSE
θ value	0.47712 (rank : 91)	NC score	0.023266 (rank : 304)
Query Neighborhood Hits	174	Target Neighborhood Hits	189	Shared Neighborhood Hits	10
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

SRRM1_MOUSE
θ value	0.47712 (rank : 92)	NC score	0.032301 (rank : 280)
Query Neighborhood Hits	174	Target Neighborhood Hits	966	Shared Neighborhood Hits	23
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

2A5D_HUMAN
θ value	0.62314 (rank : 93)	NC score	0.017071 (rank : 319)
Query Neighborhood Hits	174	Target Neighborhood Hits	59	Shared Neighborhood Hits	6
SwissProt Accessions	Q14738, O00494, O00696, Q15171	Gene names	PPP2R5D
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A, B subunit, B' delta isoform) (PP2A, B subunit, B56 delta isoform) (PP2A, B subunit, PR61 delta isoform) (PP2A, B subunit, R5 delta isoform).

APC_HUMAN
θ value	0.62314 (rank : 94)	NC score	0.041397 (rank : 270)
Query Neighborhood Hits	174	Target Neighborhood Hits	603	Shared Neighborhood Hits	25
SwissProt Accessions	P25054, Q15162, Q15163, Q93042	Gene names	APC, DP2.5
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC).

DPOLL_MOUSE
θ value	0.62314 (rank : 95)	NC score	0.020304 (rank : 312)
Query Neighborhood Hits	174	Target Neighborhood Hits	71	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QXE2, Q9CTJ1	Gene names	Poll, Polk
Domain Architecture
Description	DNA polymerase lambda (EC 2.7.7.7) (EC 4.2.99.-) (Pol Lambda) (DNA polymerase kappa).

MYPN_HUMAN
θ value	0.62314 (rank : 96)	NC score	0.029783 (rank : 286)
Query Neighborhood Hits	174	Target Neighborhood Hits	418	Shared Neighborhood Hits	5
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

FBX38_MOUSE
θ value	0.813845 (rank : 97)	NC score	0.022746 (rank : 306)
Query Neighborhood Hits	174	Target Neighborhood Hits	60	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BMI0, Q8BTQ4, Q8C0H4	Gene names	Fbxo38
Domain Architecture	No domain graphic available
Description	F-box only protein 38 (Modulator of KLF7 activity) (MoKA).

SRRM1_HUMAN
θ value	0.813845 (rank : 98)	NC score	0.030928 (rank : 284)
Query Neighborhood Hits	174	Target Neighborhood Hits	690	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

FIS1_MOUSE
θ value	1.06291 (rank : 99)	NC score	0.039766 (rank : 271)
Query Neighborhood Hits	174	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CQ92	Gene names	Fis1, Ttc11
Domain Architecture	No domain graphic available
Description	Mitochondrial fission 1 protein (Fis1 homolog) (Tetratricopeptide repeat protein 11) (TPR repeat protein 11).

HMMR_MOUSE
θ value	1.06291 (rank : 100)	NC score	0.033249 (rank : 275)
Query Neighborhood Hits	174	Target Neighborhood Hits	1178	Shared Neighborhood Hits	34
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

SEPT6_HUMAN
θ value	1.06291 (rank : 101)	NC score	0.026804 (rank : 292)
Query Neighborhood Hits	174	Target Neighborhood Hits	220	Shared Neighborhood Hits	14
SwissProt Accessions	Q14141, Q5JTK0, Q969W5, Q96A13, Q96GR1, Q96P86, Q96P87	Gene names	SEPT6, KIAA0128, SEP2
Domain Architecture
Description	Septin-6.

SET1A_HUMAN
θ value	1.06291 (rank : 102)	NC score	0.023466 (rank : 300)
Query Neighborhood Hits	174	Target Neighborhood Hits	690	Shared Neighborhood Hits	26
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

TMF1_HUMAN
θ value	1.06291 (rank : 103)	NC score	0.023879 (rank : 298)
Query Neighborhood Hits	174	Target Neighborhood Hits	987	Shared Neighborhood Hits	34
SwissProt Accessions	P82094	Gene names	TMF1
Domain Architecture	No domain graphic available
Description	TATA element modulatory factor (TMF).

MYST4_MOUSE
θ value	1.38821 (rank : 104)	NC score	0.018481 (rank : 315)
Query Neighborhood Hits	174	Target Neighborhood Hits	416	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BRB7, Q7TNW5, Q8BG35, Q8C441, Q9JKX5	Gene names	Myst4
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Querkopf protein).

SI1L1_HUMAN
θ value	1.38821 (rank : 105)	NC score	0.020221 (rank : 313)
Query Neighborhood Hits	174	Target Neighborhood Hits	162	Shared Neighborhood Hits	6
SwissProt Accessions	O43166, O95321, Q9UDU4, Q9UNU4	Gene names	SIPA1L1, E6TP1, KIAA0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1 (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6- targeted protein 1).

ULA1_MOUSE
θ value	1.38821 (rank : 106)	NC score	0.026838 (rank : 291)
Query Neighborhood Hits	174	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VBW6, Q8CFL6	Gene names	Appbp1
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 regulatory subunit (Amyloid protein-binding protein 1) (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1).

AFF1_HUMAN
θ value	1.81305 (rank : 107)	NC score	0.027154 (rank : 290)
Query Neighborhood Hits	174	Target Neighborhood Hits	506	Shared Neighborhood Hits	20
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

GNAI2_MOUSE
θ value	1.81305 (rank : 108)	NC score	0.008422 (rank : 351)
Query Neighborhood Hits	174	Target Neighborhood Hits	70	Shared Neighborhood Hits	3
SwissProt Accessions	P08752, Q6P1C0	Gene names	Gnai2, Gnai-2
Domain Architecture
Description	Guanine nucleotide-binding protein G(i), alpha-2 subunit (Adenylate cyclase-inhibiting G alpha protein).

GOGA4_HUMAN
θ value	1.81305 (rank : 109)	NC score	0.032906 (rank : 276)
Query Neighborhood Hits	174	Target Neighborhood Hits	2034	Shared Neighborhood Hits	55
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

GSCR2_HUMAN
θ value	1.81305 (rank : 110)	NC score	0.029459 (rank : 287)
Query Neighborhood Hits	174	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NZM5, Q9BTC6, Q9HAX6, Q9NPP1, Q9NPR4, Q9UFI2	Gene names	GLTSCR2
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 2 protein (p60).

INSM1_HUMAN
θ value	1.81305 (rank : 111)	NC score	0.001789 (rank : 361)
Query Neighborhood Hits	174	Target Neighborhood Hits	683	Shared Neighborhood Hits	4
SwissProt Accessions	Q01101	Gene names	INSM1, IA1
Domain Architecture	No domain graphic available
Description	Insulinoma-associated protein 1 (Zinc finger protein IA-1).

K0226_MOUSE
θ value	1.81305 (rank : 112)	NC score	0.024314 (rank : 296)
Query Neighborhood Hits	174	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q80U62, Q3TAX3, Q3TDF7, Q3TDU2, Q6P9T7, Q6PG18, Q8BMP7, Q8BY22	Gene names	Kiaa0226
Domain Architecture	No domain graphic available
Description	Protein KIAA0226.

K0460_HUMAN
θ value	1.81305 (rank : 113)	NC score	0.020381 (rank : 311)
Query Neighborhood Hits	174	Target Neighborhood Hits	357	Shared Neighborhood Hits	20
SwissProt Accessions	Q5VT52, O75048, Q5VT53, Q6MZL4, Q86XD2	Gene names	KIAA0460
Domain Architecture	No domain graphic available
Description	Protein KIAA0460.

LZTS2_MOUSE
θ value	1.81305 (rank : 114)	NC score	0.022733 (rank : 307)
Query Neighborhood Hits	174	Target Neighborhood Hits	423	Shared Neighborhood Hits	18
SwissProt Accessions	Q91YU6, Q569X6	Gene names	Lzts2, Kiaa1813
Domain Architecture
Description	Leucine zipper putative tumor suppressor 2.

MYST4_HUMAN
θ value	1.81305 (rank : 115)	NC score	0.017970 (rank : 316)
Query Neighborhood Hits	174	Target Neighborhood Hits	671	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

STAG3_MOUSE
θ value	1.81305 (rank : 116)	NC score	0.013824 (rank : 333)
Query Neighborhood Hits	174	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	O70576	Gene names	Stag3
Domain Architecture
Description	Cohesin subunit SA-3 (Stromal antigen 3) (Stromalin 3) (SCC3 homolog 3).

ULA1_HUMAN
θ value	1.81305 (rank : 117)	NC score	0.025812 (rank : 293)
Query Neighborhood Hits	174	Target Neighborhood Hits	18	Shared Neighborhood Hits	4
SwissProt Accessions	Q13564	Gene names	APPBP1
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 regulatory subunit (Amyloid protein-binding protein 1) (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Protooncogene protein 1) (HPP1).

CT2NL_HUMAN
θ value	2.36792 (rank : 118)	NC score	0.031426 (rank : 282)
Query Neighborhood Hits	174	Target Neighborhood Hits	1059	Shared Neighborhood Hits	34
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

MYH11_HUMAN
θ value	2.36792 (rank : 119)	NC score	0.016680 (rank : 320)
Query Neighborhood Hits	174	Target Neighborhood Hits	1806	Shared Neighborhood Hits	44
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

NOL4_MOUSE
θ value	2.36792 (rank : 120)	NC score	0.015794 (rank : 324)
Query Neighborhood Hits	174	Target Neighborhood Hits	44	Shared Neighborhood Hits	4
SwissProt Accessions	P60954	Gene names	Nol4
Domain Architecture	No domain graphic available
Description	Nucleolar protein 4.

TR240_HUMAN
θ value	2.36792 (rank : 121)	NC score	0.015016 (rank : 330)
Query Neighborhood Hits	174	Target Neighborhood Hits	99	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UHV7, O60334	Gene names	THRAP1, ARC250, KIAA0593, TRAP240
Domain Architecture
Description	Thyroid hormone receptor-associated protein complex 240 kDa component (Trap240) (Thyroid hormone receptor-associated protein 1) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP 250) (Activator-recruited cofactor 250 kDa component) (ARC250).

AFF4_MOUSE
θ value	3.0926 (rank : 122)	NC score	0.023312 (rank : 302)
Query Neighborhood Hits	174	Target Neighborhood Hits	581	Shared Neighborhood Hits	29
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

DMD_HUMAN
θ value	3.0926 (rank : 123)	NC score	0.024817 (rank : 295)
Query Neighborhood Hits	174	Target Neighborhood Hits	1135	Shared Neighborhood Hits	32
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

FIS1_HUMAN
θ value	3.0926 (rank : 124)	NC score	0.032843 (rank : 278)
Query Neighborhood Hits	174	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y3D6, Q9BTP3	Gene names	FIS1, TTC11
Domain Architecture	No domain graphic available
Description	Mitochondrial fission 1 protein (Fis1 homolog) (hFis1) (Tetratricopeptide repeat protein 11) (TPR repeat protein 11).

IF140_HUMAN
θ value	3.0926 (rank : 125)	NC score	0.017240 (rank : 318)
Query Neighborhood Hits	174	Target Neighborhood Hits	111	Shared Neighborhood Hits	2
SwissProt Accessions	Q96RY7, O60332	Gene names	IFT140, KIAA0590, WDTC2
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 140 homolog (WD and tetratricopeptide repeats protein 2).

K0226_HUMAN
θ value	3.0926 (rank : 126)	NC score	0.022002 (rank : 308)
Query Neighborhood Hits	174	Target Neighborhood Hits	92	Shared Neighborhood Hits	4
SwissProt Accessions	Q92622	Gene names	KIAA0226
Domain Architecture	No domain graphic available
Description	Protein KIAA0226.

PSG9_HUMAN
θ value	3.0926 (rank : 127)	NC score	0.012466 (rank : 338)
Query Neighborhood Hits	174	Target Neighborhood Hits	221	Shared Neighborhood Hits	5
SwissProt Accessions	Q00887, Q15236, Q15237, Q8WW78, Q9UQ73	Gene names	PSG9, PSG11
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 9 precursor (PSBG-9) (Pregnancy-specific glycoprotein 9) (Pregnancy-specific beta-1 glycoprotein B) (PS-beta-B) (PS34) (Pregnancy-specific glycoprotein 7) (PSG7).

RNF12_MOUSE
θ value	3.0926 (rank : 128)	NC score	0.011685 (rank : 340)
Query Neighborhood Hits	174	Target Neighborhood Hits	159	Shared Neighborhood Hits	8
SwissProt Accessions	Q9WTV7	Gene names	Rnf12, Rlim
Domain Architecture
Description	RING finger protein 12 (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM).

SAPS1_MOUSE
θ value	3.0926 (rank : 129)	NC score	0.011045 (rank : 341)
Query Neighborhood Hits	174	Target Neighborhood Hits	144	Shared Neighborhood Hits	10
SwissProt Accessions	Q7TSI3, Q80TJ4	Gene names	Saps1, Kiaa1115
Domain Architecture	No domain graphic available
Description	SAPS domain family member 1.

SEPT6_MOUSE
θ value	3.0926 (rank : 130)	NC score	0.025543 (rank : 294)
Query Neighborhood Hits	174	Target Neighborhood Hits	244	Shared Neighborhood Hits	14
SwissProt Accessions	Q9R1T4, Q91XH2, Q9CZ94	Gene names	Sept6
Domain Architecture
Description	Septin-6.

SEPT8_MOUSE
θ value	3.0926 (rank : 131)	NC score	0.023386 (rank : 301)
Query Neighborhood Hits	174	Target Neighborhood Hits	251	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CHH9, Q80YC7, Q9ESF7	Gene names	Sept8, Kiaa0202
Domain Architecture
Description	Septin-8.

BRCA2_MOUSE
θ value	4.03905 (rank : 132)	NC score	0.013826 (rank : 332)
Query Neighborhood Hits	174	Target Neighborhood Hits	222	Shared Neighborhood Hits	11
SwissProt Accessions	P97929, O35922, P97383	Gene names	Brca2, Fancd1
Domain Architecture
Description	Breast cancer type 2 susceptibility protein homolog (Fanconi anemia group D1 protein homolog).

CABIN_HUMAN
θ value	4.03905 (rank : 133)	NC score	0.016487 (rank : 321)
Query Neighborhood Hits	174	Target Neighborhood Hits	490	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

CASQ1_HUMAN
θ value	4.03905 (rank : 134)	NC score	0.010272 (rank : 345)
Query Neighborhood Hits	174	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	P31415, Q8TBW7	Gene names	CASQ1, CASQ
Domain Architecture
Description	Calsequestrin-1 precursor (Calsequestrin, skeletal muscle isoform) (Calmitin).

CENPE_HUMAN
θ value	4.03905 (rank : 135)	NC score	0.023477 (rank : 299)
Query Neighborhood Hits	174	Target Neighborhood Hits	2060	Shared Neighborhood Hits	54
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

PROM1_MOUSE
θ value	4.03905 (rank : 136)	NC score	0.015605 (rank : 326)
Query Neighborhood Hits	174	Target Neighborhood Hits	77	Shared Neighborhood Hits	8
SwissProt Accessions	O54990, O35408	Gene names	Prom1, Prom, Proml1
Domain Architecture
Description	Prominin-1 precursor (Prominin-like protein 1) (Antigen AC133 homolog).

PSG10_HUMAN
θ value	4.03905 (rank : 137)	NC score	0.010833 (rank : 342)
Query Neighborhood Hits	174	Target Neighborhood Hits	227	Shared Neighborhood Hits	5
SwissProt Accessions	Q15235, O75244, Q15224	Gene names	PSG10, PSG12
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 10 precursor (PSBG-10) (PSBG- 12).

PSG6_HUMAN
θ value	4.03905 (rank : 138)	NC score	0.010767 (rank : 343)
Query Neighborhood Hits	174	Target Neighborhood Hits	231	Shared Neighborhood Hits	5
SwissProt Accessions	Q00889	Gene names	PSG6, CGM3, PSGGB
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 6 precursor (PSBG-6).

SEPT8_HUMAN
θ value	4.03905 (rank : 139)	NC score	0.023297 (rank : 303)
Query Neighborhood Hits	174	Target Neighborhood Hits	290	Shared Neighborhood Hits	14
SwissProt Accessions	Q92599, Q8IX36, Q8IX37, Q9BVB3	Gene names	SEPT8, KIAA0202
Domain Architecture
Description	Septin-8.

SRRM2_HUMAN
θ value	4.03905 (rank : 140)	NC score	0.032448 (rank : 279)
Query Neighborhood Hits	174	Target Neighborhood Hits	1296	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

TXND2_MOUSE
θ value	4.03905 (rank : 141)	NC score	0.019392 (rank : 314)
Query Neighborhood Hits	174	Target Neighborhood Hits	828	Shared Neighborhood Hits	36
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

4ET_HUMAN
θ value	5.27518 (rank : 142)	NC score	0.015697 (rank : 325)
Query Neighborhood Hits	174	Target Neighborhood Hits	96	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NRA8, Q8NCF2, Q9H708	Gene names	EIF4ENIF1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4E transporter (eIF4E transporter) (4E-T) (Eukaryotic translation initiation factor 4E nuclear import factor 1).

ACINU_MOUSE
θ value	5.27518 (rank : 143)	NC score	0.027841 (rank : 289)
Query Neighborhood Hits	174	Target Neighborhood Hits	712	Shared Neighborhood Hits	29
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

BNIPL_MOUSE
θ value	5.27518 (rank : 144)	NC score	0.008148 (rank : 352)
Query Neighborhood Hits	174	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q99JU7, Q923E3	Gene names	Bnipl
Domain Architecture	No domain graphic available
Description	Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein.

BRE1B_HUMAN
θ value	5.27518 (rank : 145)	NC score	0.020943 (rank : 309)
Query Neighborhood Hits	174	Target Neighborhood Hits	1040	Shared Neighborhood Hits	23
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

BRWD1_HUMAN
θ value	5.27518 (rank : 146)	NC score	0.002432 (rank : 360)
Query Neighborhood Hits	174	Target Neighborhood Hits	448	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NSI6, O43721, Q5R2V0, Q5R2V1, Q8TCV3, Q96QG9, Q96QH0, Q9NUK1	Gene names	BRWD1, C21orf107, WDR9
Domain Architecture
Description	Bromodomain and WD repeat domain-containing protein 1 (WD repeat protein 9).

JADE3_MOUSE
θ value	5.27518 (rank : 147)	NC score	0.008956 (rank : 348)
Query Neighborhood Hits	174	Target Neighborhood Hits	174	Shared Neighborhood Hits	13
SwissProt Accessions	Q6IE82, Q6ZQG2	Gene names	Phf16, Jade3, Kiaa0215
Domain Architecture	No domain graphic available
Description	Protein Jade-3 (PHD finger protein 16).

LPIN1_MOUSE
θ value	5.27518 (rank : 148)	NC score	0.009335 (rank : 347)
Query Neighborhood Hits	174	Target Neighborhood Hits	85	Shared Neighborhood Hits	9
SwissProt Accessions	Q91ZP3, Q9CQI2, Q9JLG6	Gene names	Lpin1, Fld
Domain Architecture
Description	Lipin-1 (Fatty liver dystrophy protein).

TCF20_MOUSE
θ value	5.27518 (rank : 149)	NC score	0.023186 (rank : 305)
Query Neighborhood Hits	174	Target Neighborhood Hits	396	Shared Neighborhood Hits	30
SwissProt Accessions	Q9EPQ8, Q60792	Gene names	Tcf20, Spbp
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP).

UBP42_HUMAN
θ value	5.27518 (rank : 150)	NC score	0.008914 (rank : 349)
Query Neighborhood Hits	174	Target Neighborhood Hits	445	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

WDR22_HUMAN
θ value	5.27518 (rank : 151)	NC score	0.007317 (rank : 354)
Query Neighborhood Hits	174	Target Neighborhood Hits	328	Shared Neighborhood Hits	12
SwissProt Accessions	Q96JK2, O60559, Q8N3V3, Q8N3V5	Gene names	WDR22, BCRG2, KIAA1824
Domain Architecture
Description	WD repeat protein 22 (Breakpoint cluster region protein 2) (BCRP2).

FA13A_HUMAN
θ value	6.88961 (rank : 152)	NC score	0.020621 (rank : 310)
Query Neighborhood Hits	174	Target Neighborhood Hits	102	Shared Neighborhood Hits	7
SwissProt Accessions	O94988, Q8NBA3	Gene names	FAM13A1, KIAA0914
Domain Architecture	No domain graphic available
Description	Protein FAM13A1.

FOXN3_HUMAN
θ value	6.88961 (rank : 153)	NC score	0.001697 (rank : 362)
Query Neighborhood Hits	174	Target Neighborhood Hits	121	Shared Neighborhood Hits	3
SwissProt Accessions	O00409, Q96II7, Q9UIE7	Gene names	CHES1, FOXN3
Domain Architecture
Description	Checkpoint suppressor 1 (Forkhead box protein N3).

INSM1_MOUSE
θ value	6.88961 (rank : 154)	NC score	0.000076 (rank : 365)
Query Neighborhood Hits	174	Target Neighborhood Hits	678	Shared Neighborhood Hits	4
SwissProt Accessions	Q63ZV0, Q9Z113	Gene names	Insm1, Ia1
Domain Architecture	No domain graphic available
Description	Insulinoma-associated protein 1 (Zinc finger protein IA-1).

MUC1_MOUSE
θ value	6.88961 (rank : 155)	NC score	0.014308 (rank : 331)
Query Neighborhood Hits	174	Target Neighborhood Hits	388	Shared Neighborhood Hits	12
SwissProt Accessions	Q02496	Gene names	Muc1, Muc-1
Domain Architecture
Description	Mucin-1 precursor (Polymorphic epithelial mucin) (PEMT) (Episialin).

MYH11_MOUSE
θ value	6.88961 (rank : 156)	NC score	0.015265 (rank : 328)
Query Neighborhood Hits	174	Target Neighborhood Hits	1777	Shared Neighborhood Hits	37
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

NCOA6_HUMAN
θ value	6.88961 (rank : 157)	NC score	0.024155 (rank : 297)
Query Neighborhood Hits	174	Target Neighborhood Hits	1202	Shared Neighborhood Hits	35
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

SRRM2_MOUSE
θ value	6.88961 (rank : 158)	NC score	0.031729 (rank : 281)
Query Neighborhood Hits	174	Target Neighborhood Hits	1470	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

ST2B1_MOUSE
θ value	6.88961 (rank : 159)	NC score	0.003481 (rank : 359)
Query Neighborhood Hits	174	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	O35400, Q8K472, Q91V03	Gene names	Sult2b1, Sult2b
Domain Architecture	No domain graphic available
Description	Sulfotransferase family cytosolic 2B member 1 (EC 2.8.2.2) (Sulfotransferase 2B1) (Sulfotransferase 2B) (Alcohol sulfotransferase) (Hydroxysteroid sulfotransferase 2).

UBP37_HUMAN
θ value	6.88961 (rank : 160)	NC score	0.005618 (rank : 358)
Query Neighborhood Hits	174	Target Neighborhood Hits	208	Shared Neighborhood Hits	11
SwissProt Accessions	Q86T82, Q9HCH8	Gene names	USP37, KIAA1594
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.1.2.15) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37) (Deubiquitinating enzyme 37).

ABTB2_HUMAN
θ value	8.99809 (rank : 161)	NC score	0.001177 (rank : 364)
Query Neighborhood Hits	174	Target Neighborhood Hits	391	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N961, Q6MZW4, Q8NB44	Gene names	ABTB2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

ABTB2_MOUSE
θ value	8.99809 (rank : 162)	NC score	0.001188 (rank : 363)
Query Neighborhood Hits	174	Target Neighborhood Hits	414	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TQI7	Gene names	Abtb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

B2L12_HUMAN
θ value	8.99809 (rank : 163)	NC score	0.013128 (rank : 334)
Query Neighborhood Hits	174	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HB09, Q3SY11, Q96I96, Q9HB08	Gene names	BCL2L12, BPR
Domain Architecture	No domain graphic available
Description	Bcl-2-related proline-rich protein (Bcl-2-like 12 protein).

CHD2_HUMAN
θ value	8.99809 (rank : 164)	NC score	0.007477 (rank : 353)
Query Neighborhood Hits	174	Target Neighborhood Hits	360	Shared Neighborhood Hits	15
SwissProt Accessions	O14647	Gene names	CHD2
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 2 (EC 3.6.1.-) (ATP- dependent helicase CHD2) (CHD-2).

CTR9_MOUSE
θ value	8.99809 (rank : 165)	NC score	0.017956 (rank : 317)
Query Neighborhood Hits	174	Target Neighborhood Hits	427	Shared Neighborhood Hits	24
SwissProt Accessions	Q62018, Q3UFF5, Q3UY40, Q66JX4, Q7TPS6, Q8BND9, Q8BRD1, Q8C9W7, Q8C9Y3, Q8CHI1	Gene names	Ctr9, Kiaa0155, Sh2bp1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) (Tetratricopeptide repeat-containing, SH2-binding phosphoprotein of 150 kDa) (TPR-containing, SH2-binding phosphoprotein of 150 kDa) (p150TSP).

IQGA2_HUMAN
θ value	8.99809 (rank : 166)	NC score	0.005787 (rank : 357)
Query Neighborhood Hits	174	Target Neighborhood Hits	200	Shared Neighborhood Hits	9
SwissProt Accessions	Q13576	Gene names	IQGAP2
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP2.

KS6B2_HUMAN
θ value	8.99809 (rank : 167)	NC score	0.007192 (rank : 355)
Query Neighborhood Hits	174	Target Neighborhood Hits	858	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

PELP1_MOUSE
θ value	8.99809 (rank : 168)	NC score	0.006770 (rank : 356)
Query Neighborhood Hits	174	Target Neighborhood Hits	709	Shared Neighborhood Hits	18
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

PRDM2_HUMAN
θ value	8.99809 (rank : 169)	NC score	-0.003219 (rank : 366)
Query Neighborhood Hits	174	Target Neighborhood Hits	1135	Shared Neighborhood Hits	14
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

SETBP_HUMAN
θ value	8.99809 (rank : 170)	NC score	0.012379 (rank : 339)
Query Neighborhood Hits	174	Target Neighborhood Hits	305	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y6X0, Q9UEF3	Gene names	SETBP1, KIAA0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

SETX_HUMAN
θ value	8.99809 (rank : 171)	NC score	0.012556 (rank : 337)
Query Neighborhood Hits	174	Target Neighborhood Hits	368	Shared Neighborhood Hits	21
SwissProt Accessions	Q7Z333, O75120, Q3KQX4, Q68DW5, Q6AZD7, Q7Z3J6, Q8WX33, Q9H9D1, Q9NVP9	Gene names	SETX, ALS4, KIAA0625, SCAR1
Domain Architecture
Description	Probable helicase senataxin (EC 3.6.1.-) (SEN1 homolog).

STAG3_HUMAN
θ value	8.99809 (rank : 172)	NC score	0.012901 (rank : 335)
Query Neighborhood Hits	174	Target Neighborhood Hits	41	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UJ98, Q8NDP3	Gene names	STAG3
Domain Architecture
Description	Cohesin subunit SA-3 (Stromal antigen 3) (Stromalin 3) (SCC3 homolog 3).

TRH_HUMAN
θ value	8.99809 (rank : 173)	NC score	0.015507 (rank : 327)
Query Neighborhood Hits	174	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	P20396, Q2TB83	Gene names	TRH
Domain Architecture
Description	Thyroliberin precursor [Contains: Prothyroliberin; Thyroliberin (Thyrotropin-releasing hormone) (TRH) (Thyrotropin-releasing factor) (TRF) (TSH-releasing factor) (Protirelin)].

VDP_MOUSE
θ value	8.99809 (rank : 174)	NC score	0.009616 (rank : 346)
Query Neighborhood Hits	174	Target Neighborhood Hits	469	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Z1Z0, Q3T9L9, Q3TH58, Q3U1C7, Q3UMW6, Q91WE7, Q99JZ5	Gene names	Vdp
Domain Architecture	No domain graphic available
Description	General vesicular transport factor p115 (Transcytosis-associated protein) (TAP) (Vesicle docking protein).

ABI1_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.118342 (rank : 132)
Query Neighborhood Hits	174	Target Neighborhood Hits	257	Shared Neighborhood Hits	23
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 176)	NC score	0.126201 (rank : 120)
Query Neighborhood Hits	174	Target Neighborhood Hits	246	Shared Neighborhood Hits	23
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.133797 (rank : 110)
Query Neighborhood Hits	174	Target Neighborhood Hits	350	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 178)	NC score	0.132843 (rank : 112)
Query Neighborhood Hits	174	Target Neighborhood Hits	266	Shared Neighborhood Hits	23
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 179)	NC score	0.110886 (rank : 141)
Query Neighborhood Hits	174	Target Neighborhood Hits	227	Shared Neighborhood Hits	23
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 180)	NC score	0.106602 (rank : 147)
Query Neighborhood Hits	174	Target Neighborhood Hits	227	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AHI1_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.111185 (rank : 140)
Query Neighborhood Hits	174	Target Neighborhood Hits	537	Shared Neighborhood Hits	30
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 182)	NC score	0.107228 (rank : 146)
Query Neighborhood Hits	174	Target Neighborhood Hits	496	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ALS2_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.059327 (rank : 239)
Query Neighborhood Hits	174	Target Neighborhood Hits	121	Shared Neighborhood Hits	17
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

ALS2_MOUSE
θ value	θ > 10 (rank : 184)	NC score	0.068120 (rank : 213)
Query Neighborhood Hits	174	Target Neighborhood Hits	111	Shared Neighborhood Hits	17
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

ANM2_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.095336 (rank : 156)
Query Neighborhood Hits	174	Target Neighborhood Hits	175	Shared Neighborhood Hits	18
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 186)	NC score	0.087388 (rank : 176)
Query Neighborhood Hits	174	Target Neighborhood Hits	175	Shared Neighborhood Hits	18
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHGC_MOUSE
θ value	θ > 10 (rank : 187)	NC score	0.476392 (rank : 58)
Query Neighborhood Hits	174	Target Neighborhood Hits	344	Shared Neighborhood Hits	71
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ASPP1_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.066863 (rank : 219)
Query Neighborhood Hits	174	Target Neighborhood Hits	956	Shared Neighborhood Hits	35
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_MOUSE
θ value	θ > 10 (rank : 189)	NC score	0.070973 (rank : 203)
Query Neighborhood Hits	174	Target Neighborhood Hits	1244	Shared Neighborhood Hits	47
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP2_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.052879 (rank : 253)
Query Neighborhood Hits	174	Target Neighborhood Hits	1156	Shared Neighborhood Hits	44
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

BAIP2_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.063256 (rank : 229)
Query Neighborhood Hits	174	Target Neighborhood Hits	192	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	θ > 10 (rank : 192)	NC score	0.064935 (rank : 227)
Query Neighborhood Hits	174	Target Neighborhood Hits	185	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BCAR1_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.088601 (rank : 170)
Query Neighborhood Hits	174	Target Neighborhood Hits	554	Shared Neighborhood Hits	27
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	θ > 10 (rank : 194)	NC score	0.091363 (rank : 164)
Query Neighborhood Hits	174	Target Neighborhood Hits	438	Shared Neighborhood Hits	22
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BI2L1_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.116157 (rank : 134)
Query Neighborhood Hits	174	Target Neighborhood Hits	156	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 196)	NC score	0.090736 (rank : 166)
Query Neighborhood Hits	174	Target Neighborhood Hits	197	Shared Neighborhood Hits	24
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CASL_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.086771 (rank : 177)
Query Neighborhood Hits	174	Target Neighborhood Hits	259	Shared Neighborhood Hits	25
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	θ > 10 (rank : 198)	NC score	0.082470 (rank : 183)
Query Neighborhood Hits	174	Target Neighborhood Hits	225	Shared Neighborhood Hits	21
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CD2AP_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.189158 (rank : 82)
Query Neighborhood Hits	174	Target Neighborhood Hits	315	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.187952 (rank : 83)
Query Neighborhood Hits	174	Target Neighborhood Hits	336	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CNN1_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.073158 (rank : 196)
Query Neighborhood Hits	174	Target Neighborhood Hits	38	Shared Neighborhood Hits	9
SwissProt Accessions	P51911, O00638, Q15416, Q8IY93, Q99438	Gene names	CNN1
Domain Architecture
Description	Calponin-1 (Calponin H1, smooth muscle) (Basic calponin).

CNN1_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.073031 (rank : 197)
Query Neighborhood Hits	174	Target Neighborhood Hits	37	Shared Neighborhood Hits	9
SwissProt Accessions	Q08091	Gene names	Cnn1
Domain Architecture
Description	Calponin-1 (Calponin H1, smooth muscle) (Basic calponin).

CNN2_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.067529 (rank : 216)
Query Neighborhood Hits	174	Target Neighborhood Hits	37	Shared Neighborhood Hits	9
SwissProt Accessions	Q99439, Q92578	Gene names	CNN2
Domain Architecture
Description	Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin).

CNN2_MOUSE
θ value	θ > 10 (rank : 204)	NC score	0.072074 (rank : 201)
Query Neighborhood Hits	174	Target Neighborhood Hits	39	Shared Neighborhood Hits	9
SwissProt Accessions	Q08093	Gene names	Cnn2
Domain Architecture
Description	Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin).

CNN3_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.068981 (rank : 209)
Query Neighborhood Hits	174	Target Neighborhood Hits	43	Shared Neighborhood Hits	9
SwissProt Accessions	Q15417	Gene names	CNN3
Domain Architecture
Description	Calponin-3 (Calponin, acidic isoform).

CNN3_MOUSE
θ value	θ > 10 (rank : 206)	NC score	0.069137 (rank : 208)
Query Neighborhood Hits	174	Target Neighborhood Hits	45	Shared Neighborhood Hits	9
SwissProt Accessions	Q9DAW9, Q3TW23	Gene names	Cnn3
Domain Architecture	No domain graphic available
Description	Calponin-3 (Calponin, acidic isoform).

CRKL_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.131457 (rank : 114)
Query Neighborhood Hits	174	Target Neighborhood Hits	313	Shared Neighborhood Hits	20
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.129070 (rank : 118)
Query Neighborhood Hits	174	Target Neighborhood Hits	307	Shared Neighborhood Hits	20
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.122285 (rank : 127)
Query Neighborhood Hits	174	Target Neighborhood Hits	308	Shared Neighborhood Hits	21
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 210)	NC score	0.125248 (rank : 123)
Query Neighborhood Hits	174	Target Neighborhood Hits	314	Shared Neighborhood Hits	22
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CT032_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.093806 (rank : 160)
Query Neighborhood Hits	174	Target Neighborhood Hits	235	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DBNL_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.108095 (rank : 144)
Query Neighborhood Hits	174	Target Neighborhood Hits	244	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.105470 (rank : 148)
Query Neighborhood Hits	174	Target Neighborhood Hits	306	Shared Neighborhood Hits	22
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DDEF1_MOUSE
θ value	θ > 10 (rank : 214)	NC score	0.061083 (rank : 232)
Query Neighborhood Hits	174	Target Neighborhood Hits	592	Shared Neighborhood Hits	29
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.068831 (rank : 211)
Query Neighborhood Hits	174	Target Neighborhood Hits	599	Shared Neighborhood Hits	33
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	θ > 10 (rank : 216)	NC score	0.068874 (rank : 210)
Query Neighborhood Hits	174	Target Neighborhood Hits	625	Shared Neighborhood Hits	33
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

EEA1_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.059872 (rank : 238)
Query Neighborhood Hits	174	Target Neighborhood Hits	1796	Shared Neighborhood Hits	54
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

EEA1_MOUSE
θ value	θ > 10 (rank : 218)	NC score	0.066272 (rank : 222)
Query Neighborhood Hits	174	Target Neighborhood Hits	1637	Shared Neighborhood Hits	54
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

EFS_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.073913 (rank : 194)
Query Neighborhood Hits	174	Target Neighborhood Hits	348	Shared Neighborhood Hits	24
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.076426 (rank : 188)
Query Neighborhood Hits	174	Target Neighborhood Hits	389	Shared Neighborhood Hits	26
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

EPS8_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.050303 (rank : 265)
Query Neighborhood Hits	174	Target Neighborhood Hits	151	Shared Neighborhood Hits	19
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.051767 (rank : 257)
Query Neighborhood Hits	174	Target Neighborhood Hits	157	Shared Neighborhood Hits	19
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L2_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.053230 (rank : 250)
Query Neighborhood Hits	174	Target Neighborhood Hits	193	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_MOUSE
θ value	θ > 10 (rank : 224)	NC score	0.054653 (rank : 245)
Query Neighborhood Hits	174	Target Neighborhood Hits	169	Shared Neighborhood Hits	18
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L3_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.050993 (rank : 260)
Query Neighborhood Hits	174	Target Neighborhood Hits	206	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L3_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.050647 (rank : 263)
Query Neighborhood Hits	174	Target Neighborhood Hits	168	Shared Neighborhood Hits	17
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FNBP2_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.074074 (rank : 193)
Query Neighborhood Hits	174	Target Neighborhood Hits	432	Shared Neighborhood Hits	28
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

FYCO1_HUMAN
θ value	θ > 10 (rank : 228)	NC score	0.052438 (rank : 254)
Query Neighborhood Hits	174	Target Neighborhood Hits	1149	Shared Neighborhood Hits	41
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

FYCO1_MOUSE
θ value	θ > 10 (rank : 229)	NC score	0.053075 (rank : 252)
Query Neighborhood Hits	174	Target Neighborhood Hits	1059	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

FYV1_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.072713 (rank : 198)
Query Neighborhood Hits	174	Target Neighborhood Hits	217	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	θ > 10 (rank : 231)	NC score	0.067734 (rank : 215)
Query Neighborhood Hits	174	Target Neighborhood Hits	191	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

GNRP_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.398111 (rank : 68)
Query Neighborhood Hits	174	Target Neighborhood Hits	239	Shared Neighborhood Hits	64
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 233)	NC score	0.445574 (rank : 62)
Query Neighborhood Hits	174	Target Neighborhood Hits	191	Shared Neighborhood Hits	64
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GRAP2_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.136701 (rank : 103)
Query Neighborhood Hits	174	Target Neighborhood Hits	304	Shared Neighborhood Hits	22
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 235)	NC score	0.136257 (rank : 104)
Query Neighborhood Hits	174	Target Neighborhood Hits	297	Shared Neighborhood Hits	20
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.164094 (rank : 90)
Query Neighborhood Hits	174	Target Neighborhood Hits	307	Shared Neighborhood Hits	23
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 237)	NC score	0.163217 (rank : 91)
Query Neighborhood Hits	174	Target Neighborhood Hits	309	Shared Neighborhood Hits	24
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.148311 (rank : 99)
Query Neighborhood Hits	174	Target Neighborhood Hits	310	Shared Neighborhood Hits	21
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 239)	NC score	0.148286 (rank : 100)
Query Neighborhood Hits	174	Target Neighborhood Hits	312	Shared Neighborhood Hits	21
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRP3_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.077883 (rank : 186)
Query Neighborhood Hits	174	Target Neighborhood Hits	131	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

HCLS1_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.133236 (rank : 111)
Query Neighborhood Hits	174	Target Neighborhood Hits	358	Shared Neighborhood Hits	28
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 242)	NC score	0.134396 (rank : 109)
Query Neighborhood Hits	174	Target Neighborhood Hits	329	Shared Neighborhood Hits	28
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HGS_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.088082 (rank : 172)
Query Neighborhood Hits	174	Target Neighborhood Hits	517	Shared Neighborhood Hits	24
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	θ > 10 (rank : 244)	NC score	0.088569 (rank : 171)
Query Neighborhood Hits	174	Target Neighborhood Hits	589	Shared Neighborhood Hits	25
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

IASPP_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.069639 (rank : 207)
Query Neighborhood Hits	174	Target Neighborhood Hits	688	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IASPP_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.076052 (rank : 189)
Query Neighborhood Hits	174	Target Neighborhood Hits	1024	Shared Neighborhood Hits	41
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

LASP1_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.093988 (rank : 159)
Query Neighborhood Hits	174	Target Neighborhood Hits	293	Shared Neighborhood Hits	22
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.091613 (rank : 163)
Query Neighborhood Hits	174	Target Neighborhood Hits	297	Shared Neighborhood Hits	23
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LBC_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.459788 (rank : 60)
Query Neighborhood Hits	174	Target Neighborhood Hits	90	Shared Neighborhood Hits	58
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

LMO7_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.093038 (rank : 161)
Query Neighborhood Hits	174	Target Neighborhood Hits	507	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

MIA_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.070058 (rank : 206)
Query Neighborhood Hits	174	Target Neighborhood Hits	19	Shared Neighborhood Hits	8
SwissProt Accessions	Q16674	Gene names	MIA
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity).

MIA_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.071554 (rank : 202)
Query Neighborhood Hits	174	Target Neighborhood Hits	17	Shared Neighborhood Hits	7
SwissProt Accessions	Q61865, O09086, P97495	Gene names	Mia, Cdrap, Mia1
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity) (Cartilage-derived retinoic acid-sensitive protein) (CD-RAP).

MTMR3_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.053656 (rank : 249)
Query Neighborhood Hits	174	Target Neighborhood Hits	163	Shared Neighborhood Hits	13
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

MYO1E_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.060924 (rank : 235)
Query Neighborhood Hits	174	Target Neighborhood Hits	293	Shared Neighborhood Hits	28
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

MYO1F_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.061012 (rank : 233)
Query Neighborhood Hits	174	Target Neighborhood Hits	275	Shared Neighborhood Hits	25
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
θ value	θ > 10 (rank : 256)	NC score	0.062120 (rank : 231)
Query Neighborhood Hits	174	Target Neighborhood Hits	262	Shared Neighborhood Hits	25
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

NCF1_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.203836 (rank : 76)
Query Neighborhood Hits	174	Target Neighborhood Hits	198	Shared Neighborhood Hits	26
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.186884 (rank : 85)
Query Neighborhood Hits	174	Target Neighborhood Hits	198	Shared Neighborhood Hits	25
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.166198 (rank : 88)
Query Neighborhood Hits	174	Target Neighborhood Hits	229	Shared Neighborhood Hits	25
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.157548 (rank : 95)
Query Neighborhood Hits	174	Target Neighborhood Hits	161	Shared Neighborhood Hits	19
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 261)	NC score	0.158414 (rank : 94)
Query Neighborhood Hits	174	Target Neighborhood Hits	177	Shared Neighborhood Hits	21
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.160354 (rank : 93)
Query Neighborhood Hits	174	Target Neighborhood Hits	312	Shared Neighborhood Hits	26
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.154481 (rank : 97)
Query Neighborhood Hits	174	Target Neighborhood Hits	310	Shared Neighborhood Hits	26
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NEBL_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.089593 (rank : 169)
Query Neighborhood Hits	174	Target Neighborhood Hits	457	Shared Neighborhood Hits	29
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NEBU_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.080896 (rank : 184)
Query Neighborhood Hits	174	Target Neighborhood Hits	420	Shared Neighborhood Hits	30
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

NOXO1_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.079555 (rank : 185)
Query Neighborhood Hits	174	Target Neighborhood Hits	100	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.091810 (rank : 162)
Query Neighborhood Hits	174	Target Neighborhood Hits	114	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.077029 (rank : 187)
Query Neighborhood Hits	174	Target Neighborhood Hits	288	Shared Neighborhood Hits	27
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.103573 (rank : 149)
Query Neighborhood Hits	174	Target Neighborhood Hits	267	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OSTF1_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.115623 (rank : 136)
Query Neighborhood Hits	174	Target Neighborhood Hits	466	Shared Neighborhood Hits	23
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.114860 (rank : 137)
Query Neighborhood Hits	174	Target Neighborhood Hits	467	Shared Neighborhood Hits	23
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

P55G_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.053908 (rank : 247)
Query Neighborhood Hits	174	Target Neighborhood Hits	451	Shared Neighborhood Hits	19
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.053707 (rank : 248)
Query Neighborhood Hits	174	Target Neighborhood Hits	401	Shared Neighborhood Hits	18
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85A_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.066810 (rank : 220)
Query Neighborhood Hits	174	Target Neighborhood Hits	479	Shared Neighborhood Hits	24
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.064754 (rank : 228)
Query Neighborhood Hits	174	Target Neighborhood Hits	435	Shared Neighborhood Hits	22
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.067044 (rank : 218)
Query Neighborhood Hits	174	Target Neighborhood Hits	543	Shared Neighborhood Hits	23
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.064996 (rank : 226)
Query Neighborhood Hits	174	Target Neighborhood Hits	519	Shared Neighborhood Hits	24
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PACN1_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.085387 (rank : 179)
Query Neighborhood Hits	174	Target Neighborhood Hits	320	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.083121 (rank : 182)
Query Neighborhood Hits	174	Target Neighborhood Hits	283	Shared Neighborhood Hits	24
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.094549 (rank : 158)
Query Neighborhood Hits	174	Target Neighborhood Hits	339	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 281)	NC score	0.095865 (rank : 154)
Query Neighborhood Hits	174	Target Neighborhood Hits	382	Shared Neighborhood Hits	34
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.087426 (rank : 175)
Query Neighborhood Hits	174	Target Neighborhood Hits	385	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.088075 (rank : 173)
Query Neighborhood Hits	174	Target Neighborhood Hits	380	Shared Neighborhood Hits	25
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PEX13_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.097728 (rank : 153)
Query Neighborhood Hits	174	Target Neighborhood Hits	128	Shared Neighborhood Hits	19
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.099916 (rank : 151)
Query Neighborhood Hits	174	Target Neighborhood Hits	126	Shared Neighborhood Hits	19
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PKHA5_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.052328 (rank : 255)
Query Neighborhood Hits	174	Target Neighborhood Hits	455	Shared Neighborhood Hits	28
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA6_HUMAN
θ value	θ > 10 (rank : 287)	NC score	0.072578 (rank : 199)
Query Neighborhood Hits	174	Target Neighborhood Hits	556	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	θ > 10 (rank : 288)	NC score	0.070669 (rank : 204)
Query Neighborhood Hits	174	Target Neighborhood Hits	591	Shared Neighborhood Hits	27
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHF1_HUMAN
θ value	θ > 10 (rank : 289)	NC score	0.193932 (rank : 80)
Query Neighborhood Hits	174	Target Neighborhood Hits	76	Shared Neighborhood Hits	18
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
θ value	θ > 10 (rank : 290)	NC score	0.191440 (rank : 81)
Query Neighborhood Hits	174	Target Neighborhood Hits	80	Shared Neighborhood Hits	17
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF2_HUMAN
θ value	θ > 10 (rank : 291)	NC score	0.196423 (rank : 78)
Query Neighborhood Hits	174	Target Neighborhood Hits	75	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	θ > 10 (rank : 292)	NC score	0.195510 (rank : 79)
Query Neighborhood Hits	174	Target Neighborhood Hits	77	Shared Neighborhood Hits	18
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PLCG1_HUMAN
θ value	θ > 10 (rank : 293)	NC score	0.123245 (rank : 126)
Query Neighborhood Hits	174	Target Neighborhood Hits	293	Shared Neighborhood Hits	20
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 294)	NC score	0.123878 (rank : 124)
Query Neighborhood Hits	174	Target Neighborhood Hits	314	Shared Neighborhood Hits	20
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.110098 (rank : 142)
Query Neighborhood Hits	174	Target Neighborhood Hits	280	Shared Neighborhood Hits	16
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP1_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.129265 (rank : 116)
Query Neighborhood Hits	174	Target Neighborhood Hits	389	Shared Neighborhood Hits	31
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.123557 (rank : 125)
Query Neighborhood Hits	174	Target Neighborhood Hits	377	Shared Neighborhood Hits	29
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

RBNS5_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.091069 (rank : 165)
Query Neighborhood Hits	174	Target Neighborhood Hits	242	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	θ > 10 (rank : 299)	NC score	0.085860 (rank : 178)
Query Neighborhood Hits	174	Target Neighborhood Hits	266	Shared Neighborhood Hits	20
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

REPS1_MOUSE
θ value	θ > 10 (rank : 300)	NC score	0.052293 (rank : 256)
Query Neighborhood Hits	174	Target Neighborhood Hits	204	Shared Neighborhood Hits	15
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS2_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.051497 (rank : 259)
Query Neighborhood Hits	174	Target Neighborhood Hits	131	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_MOUSE
θ value	θ > 10 (rank : 302)	NC score	0.051557 (rank : 258)
Query Neighborhood Hits	174	Target Neighborhood Hits	102	Shared Neighborhood Hits	7
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

RHG04_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.094883 (rank : 157)
Query Neighborhood Hits	174	Target Neighborhood Hits	307	Shared Neighborhood Hits	22
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RHG26_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.072352 (rank : 200)
Query Neighborhood Hits	174	Target Neighborhood Hits	281	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RIMB1_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.057525 (rank : 240)
Query Neighborhood Hits	174	Target Neighborhood Hits	1479	Shared Neighborhood Hits	60
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB1_MOUSE
θ value	θ > 10 (rank : 306)	NC score	0.050986 (rank : 261)
Query Neighborhood Hits	174	Target Neighborhood Hits	1376	Shared Neighborhood Hits	47
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB2_HUMAN
θ value	θ > 10 (rank : 307)	NC score	0.084991 (rank : 180)
Query Neighborhood Hits	174	Target Neighborhood Hits	263	Shared Neighborhood Hits	17
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 308)	NC score	0.084593 (rank : 181)
Query Neighborhood Hits	174	Target Neighborhood Hits	246	Shared Neighborhood Hits	21
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RUFY1_HUMAN
θ value	θ > 10 (rank : 309)	NC score	0.066233 (rank : 223)
Query Neighborhood Hits	174	Target Neighborhood Hits	848	Shared Neighborhood Hits	36
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

RUFY1_MOUSE
θ value	θ > 10 (rank : 310)	NC score	0.066716 (rank : 221)
Query Neighborhood Hits	174	Target Neighborhood Hits	765	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY2_HUMAN
θ value	θ > 10 (rank : 311)	NC score	0.063124 (rank : 230)
Query Neighborhood Hits	174	Target Neighborhood Hits	1208	Shared Neighborhood Hits	43
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

RUFY2_MOUSE
θ value	θ > 10 (rank : 312)	NC score	0.065971 (rank : 224)
Query Neighborhood Hits	174	Target Neighborhood Hits	820	Shared Neighborhood Hits	37
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

SH3G1_HUMAN
θ value	θ > 10 (rank : 313)	NC score	0.125752 (rank : 122)
Query Neighborhood Hits	174	Target Neighborhood Hits	307	Shared Neighborhood Hits	26
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 314)	NC score	0.121420 (rank : 129)
Query Neighborhood Hits	174	Target Neighborhood Hits	291	Shared Neighborhood Hits	24
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.121442 (rank : 128)
Query Neighborhood Hits	174	Target Neighborhood Hits	324	Shared Neighborhood Hits	26
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 316)	NC score	0.118473 (rank : 131)
Query Neighborhood Hits	174	Target Neighborhood Hits	319	Shared Neighborhood Hits	26
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.126165 (rank : 121)
Query Neighborhood Hits	174	Target Neighborhood Hits	222	Shared Neighborhood Hits	22
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 318)	NC score	0.129247 (rank : 117)
Query Neighborhood Hits	174	Target Neighborhood Hits	236	Shared Neighborhood Hits	23
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_HUMAN
θ value	θ > 10 (rank : 319)	NC score	0.198659 (rank : 77)
Query Neighborhood Hits	174	Target Neighborhood Hits	341	Shared Neighborhood Hits	27
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 320)	NC score	0.187647 (rank : 84)
Query Neighborhood Hits	174	Target Neighborhood Hits	332	Shared Neighborhood Hits	27
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SHAN1_HUMAN
θ value	θ > 10 (rank : 321)	NC score	0.090337 (rank : 167)
Query Neighborhood Hits	174	Target Neighborhood Hits	1041	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHAN2_MOUSE
θ value	θ > 10 (rank : 322)	NC score	0.112438 (rank : 139)
Query Neighborhood Hits	174	Target Neighborhood Hits	446	Shared Neighborhood Hits	33
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SLY_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.053154 (rank : 251)
Query Neighborhood Hits	174	Target Neighborhood Hits	81	Shared Neighborhood Hits	15
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SLY_MOUSE
θ value	θ > 10 (rank : 324)	NC score	0.054607 (rank : 246)
Query Neighborhood Hits	174	Target Neighborhood Hits	108	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SNX18_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.065199 (rank : 225)
Query Neighborhood Hits	174	Target Neighborhood Hits	207	Shared Neighborhood Hits	19
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_MOUSE
θ value	θ > 10 (rank : 326)	NC score	0.067528 (rank : 217)
Query Neighborhood Hits	174	Target Neighborhood Hits	198	Shared Neighborhood Hits	18
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX9_HUMAN
θ value	θ > 10 (rank : 327)	NC score	0.056955 (rank : 242)
Query Neighborhood Hits	174	Target Neighborhood Hits	148	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SPTA1_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.090040 (rank : 168)
Query Neighborhood Hits	174	Target Neighborhood Hits	748	Shared Neighborhood Hits	37
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA1_MOUSE
θ value	θ > 10 (rank : 329)	NC score	0.097753 (rank : 152)
Query Neighborhood Hits	174	Target Neighborhood Hits	675	Shared Neighborhood Hits	35
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.101303 (rank : 150)
Query Neighborhood Hits	174	Target Neighborhood Hits	888	Shared Neighborhood Hits	39
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SRBS1_HUMAN
θ value	θ > 10 (rank : 331)	NC score	0.174224 (rank : 86)
Query Neighborhood Hits	174	Target Neighborhood Hits	396	Shared Neighborhood Hits	33
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 332)	NC score	0.171122 (rank : 87)
Query Neighborhood Hits	174	Target Neighborhood Hits	409	Shared Neighborhood Hits	30
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 333)	NC score	0.134977 (rank : 107)
Query Neighborhood Hits	174	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 334)	NC score	0.132541 (rank : 113)
Query Neighborhood Hits	174	Target Neighborhood Hits	292	Shared Neighborhood Hits	24
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRGP1_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.075117 (rank : 190)
Query Neighborhood Hits	174	Target Neighborhood Hits	390	Shared Neighborhood Hits	28
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
θ value	θ > 10 (rank : 336)	NC score	0.073389 (rank : 195)
Query Neighborhood Hits	174	Target Neighborhood Hits	331	Shared Neighborhood Hits	25
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
θ value	θ > 10 (rank : 337)	NC score	0.074350 (rank : 192)
Query Neighborhood Hits	174	Target Neighborhood Hits	324	Shared Neighborhood Hits	24
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

STAC3_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.135026 (rank : 106)
Query Neighborhood Hits	174	Target Neighborhood Hits	228	Shared Neighborhood Hits	21
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 339)	NC score	0.136216 (rank : 105)
Query Neighborhood Hits	174	Target Neighborhood Hits	232	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 340)	NC score	0.154865 (rank : 96)
Query Neighborhood Hits	174	Target Neighborhood Hits	276	Shared Neighborhood Hits	26
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 341)	NC score	0.149218 (rank : 98)
Query Neighborhood Hits	174	Target Neighborhood Hits	268	Shared Neighborhood Hits	25
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 342)	NC score	0.137078 (rank : 102)
Query Neighborhood Hits	174	Target Neighborhood Hits	271	Shared Neighborhood Hits	24
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 343)	NC score	0.134812 (rank : 108)
Query Neighborhood Hits	174	Target Neighborhood Hits	273	Shared Neighborhood Hits	23
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 344)	NC score	0.128513 (rank : 119)
Query Neighborhood Hits	174	Target Neighborhood Hits	288	Shared Neighborhood Hits	23
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 345)	NC score	0.129627 (rank : 115)
Query Neighborhood Hits	174	Target Neighborhood Hits	285	Shared Neighborhood Hits	25
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

TAGL_HUMAN
θ value	θ > 10 (rank : 346)	NC score	0.055902 (rank : 243)
Query Neighborhood Hits	174	Target Neighborhood Hits	32	Shared Neighborhood Hits	8
SwissProt Accessions	Q01995, O15542	Gene names	TAGLN, SM22, WS3-10
Domain Architecture
Description	Transgelin (Smooth muscle protein 22-alpha) (SM22-alpha) (WS3-10) (22 kDa actin-binding protein).

TAGL_MOUSE
θ value	θ > 10 (rank : 347)	NC score	0.054670 (rank : 244)
Query Neighborhood Hits	174	Target Neighborhood Hits	33	Shared Neighborhood Hits	8
SwissProt Accessions	P37804, Q545W0	Gene names	Tagln, Sm22, Sm22a
Domain Architecture
Description	Transgelin (Smooth muscle protein 22-alpha) (SM22-alpha) (Actin- associated protein p27).

TCGAP_HUMAN
θ value	θ > 10 (rank : 348)	NC score	0.087579 (rank : 174)
Query Neighborhood Hits	174	Target Neighborhood Hits	872	Shared Neighborhood Hits	40
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 349)	NC score	0.095401 (rank : 155)
Query Neighborhood Hits	174	Target Neighborhood Hits	409	Shared Neighborhood Hits	33
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

VINEX_HUMAN
θ value	θ > 10 (rank : 350)	NC score	0.161820 (rank : 92)
Query Neighborhood Hits	174	Target Neighborhood Hits	270	Shared Neighborhood Hits	27
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 351)	NC score	0.164492 (rank : 89)
Query Neighborhood Hits	174	Target Neighborhood Hits	286	Shared Neighborhood Hits	29
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

WDFY1_HUMAN
θ value	θ > 10 (rank : 352)	NC score	0.060078 (rank : 237)
Query Neighborhood Hits	174	Target Neighborhood Hits	305	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

WDFY2_HUMAN
θ value	θ > 10 (rank : 353)	NC score	0.050191 (rank : 266)
Query Neighborhood Hits	174	Target Neighborhood Hits	332	Shared Neighborhood Hits	15
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

WDFY2_MOUSE
θ value	θ > 10 (rank : 354)	NC score	0.050337 (rank : 264)
Query Neighborhood Hits	174	Target Neighborhood Hits	337	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

WDFY3_HUMAN
θ value	θ > 10 (rank : 355)	NC score	0.060971 (rank : 234)
Query Neighborhood Hits	174	Target Neighborhood Hits	348	Shared Neighborhood Hits	17
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY3_MOUSE
θ value	θ > 10 (rank : 356)	NC score	0.060315 (rank : 236)
Query Neighborhood Hits	174	Target Neighborhood Hits	332	Shared Neighborhood Hits	16
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

ZFY16_HUMAN
θ value	θ > 10 (rank : 357)	NC score	0.115853 (rank : 135)
Query Neighborhood Hits	174	Target Neighborhood Hits	125	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY16_MOUSE
θ value	θ > 10 (rank : 358)	NC score	0.114076 (rank : 138)
Query Neighborhood Hits	174	Target Neighborhood Hits	108	Shared Neighborhood Hits	13
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY19_HUMAN
θ value	θ > 10 (rank : 359)	NC score	0.074547 (rank : 191)
Query Neighborhood Hits	174	Target Neighborhood Hits	206	Shared Neighborhood Hits	12
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ZFY19_MOUSE
θ value	θ > 10 (rank : 360)	NC score	0.067795 (rank : 214)
Query Neighborhood Hits	174	Target Neighborhood Hits	143	Shared Neighborhood Hits	13
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

ZFY21_HUMAN
θ value	θ > 10 (rank : 361)	NC score	0.107362 (rank : 145)
Query Neighborhood Hits	174	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_MOUSE
θ value	θ > 10 (rank : 362)	NC score	0.109598 (rank : 143)
Query Neighborhood Hits	174	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY28_HUMAN
θ value	θ > 10 (rank : 363)	NC score	0.117831 (rank : 133)
Query Neighborhood Hits	174	Target Neighborhood Hits	152	Shared Neighborhood Hits	16
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV1_HUMAN
θ value	θ > 10 (rank : 364)	NC score	0.070285 (rank : 205)
Query Neighborhood Hits	174	Target Neighborhood Hits	166	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
θ value	θ > 10 (rank : 365)	NC score	0.068752 (rank : 212)
Query Neighborhood Hits	174	Target Neighborhood Hits	153	Shared Neighborhood Hits	12
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

ZFYV9_HUMAN
θ value	θ > 10 (rank : 366)	NC score	0.121154 (rank : 130)
Query Neighborhood Hits	174	Target Neighborhood Hits	134	Shared Neighborhood Hits	19
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

Hits sorted by NC score

PKHG1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	174	Target Neighborhood Hits	174	Shared Neighborhood Hits	174
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHG4_MOUSE
NC score	0.829107 (rank : 2)	θ value	3.50572e-28 (rank : 9)
Query Neighborhood Hits	174	Target Neighborhood Hits	185	Shared Neighborhood Hits	69
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PREX1_HUMAN
NC score	0.827750 (rank : 3)	θ value	1.02001e-27 (rank : 10)
Query Neighborhood Hits	174	Target Neighborhood Hits	177	Shared Neighborhood Hits	73
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

MCF2_HUMAN
NC score	0.821304 (rank : 4)	θ value	5.22648e-32 (rank : 3)
Query Neighborhood Hits	174	Target Neighborhood Hits	166	Shared Neighborhood Hits	70
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ARHG9_HUMAN
NC score	0.807039 (rank : 5)	θ value	1.6813e-30 (rank : 5)
Query Neighborhood Hits	174	Target Neighborhood Hits	235	Shared Neighborhood Hits	71
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.806953 (rank : 6)	θ value	1.6813e-30 (rank : 6)
Query Neighborhood Hits	174	Target Neighborhood Hits	234	Shared Neighborhood Hits	71
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG4_HUMAN
NC score	0.797612 (rank : 7)	θ value	5.06226e-27 (rank : 12)
Query Neighborhood Hits	174	Target Neighborhood Hits	242	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

MCF2L_MOUSE
NC score	0.780043 (rank : 8)	θ value	1.37539e-32 (rank : 2)
Query Neighborhood Hits	174	Target Neighborhood Hits	255	Shared Neighborhood Hits	72
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

TIAM1_MOUSE
NC score	0.760973 (rank : 9)	θ value	4.01107e-24 (rank : 16)
Query Neighborhood Hits	174	Target Neighborhood Hits	205	Shared Neighborhood Hits	68
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_HUMAN
NC score	0.754246 (rank : 10)	θ value	1.16704e-23 (rank : 18)
Query Neighborhood Hits	174	Target Neighborhood Hits	225	Shared Neighborhood Hits	69
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ECT2_MOUSE
NC score	0.719666 (rank : 11)	θ value	1.58096e-12 (rank : 39)
Query Neighborhood Hits	174	Target Neighborhood Hits	98	Shared Neighborhood Hits	72
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

FGD3_MOUSE
NC score	0.719060 (rank : 12)	θ value	1.058e-16 (rank : 27)
Query Neighborhood Hits	174	Target Neighborhood Hits	257	Shared Neighborhood Hits	74
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

PKHG4_HUMAN
NC score	0.713698 (rank : 13)	θ value	1.57365e-28 (rank : 8)
Query Neighborhood Hits	174	Target Neighborhood Hits	200	Shared Neighborhood Hits	60
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

ECT2_HUMAN
NC score	0.705659 (rank : 14)	θ value	2.0648e-12 (rank : 40)
Query Neighborhood Hits	174	Target Neighborhood Hits	98	Shared Neighborhood Hits	71
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

FGD4_MOUSE
NC score	0.695004 (rank : 15)	θ value	1.52774e-15 (rank : 31)
Query Neighborhood Hits	174	Target Neighborhood Hits	227	Shared Neighborhood Hits	71
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD3_HUMAN
NC score	0.692447 (rank : 16)	θ value	3.40345e-15 (rank : 32)
Query Neighborhood Hits	174	Target Neighborhood Hits	249	Shared Neighborhood Hits	72
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD4_HUMAN
NC score	0.692430 (rank : 17)	θ value	2.88119e-14 (rank : 37)
Query Neighborhood Hits	174	Target Neighborhood Hits	219	Shared Neighborhood Hits	71
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD2_HUMAN
NC score	0.681396 (rank : 18)	θ value	6.00763e-12 (rank : 42)
Query Neighborhood Hits	174	Target Neighborhood Hits	151	Shared Neighborhood Hits	71
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

HAPIP_HUMAN
NC score	0.670494 (rank : 19)	θ value	1.4233e-29 (rank : 7)
Query Neighborhood Hits	174	Target Neighborhood Hits	350	Shared Neighborhood Hits	75
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ARHG8_HUMAN
NC score	0.666841 (rank : 20)	θ value	6.00763e-12 (rank : 41)
Query Neighborhood Hits	174	Target Neighborhood Hits	85	Shared Neighborhood Hits	65
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG3_HUMAN
NC score	0.665435 (rank : 21)	θ value	1.9326e-10 (rank : 50)
Query Neighborhood Hits	174	Target Neighborhood Hits	82	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

FGD2_MOUSE
NC score	0.663337 (rank : 22)	θ value	2.79066e-09 (rank : 59)
Query Neighborhood Hits	174	Target Neighborhood Hits	163	Shared Neighborhood Hits	70
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

ARHG3_MOUSE
NC score	0.662472 (rank : 23)	θ value	6.21693e-09 (rank : 61)
Query Neighborhood Hits	174	Target Neighborhood Hits	85	Shared Neighborhood Hits	64
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG7_HUMAN
NC score	0.653839 (rank : 24)	θ value	4.28545e-26 (rank : 13)
Query Neighborhood Hits	174	Target Neighborhood Hits	347	Shared Neighborhood Hits	70
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
NC score	0.652984 (rank : 25)	θ value	2.96777e-27 (rank : 11)
Query Neighborhood Hits	174	Target Neighborhood Hits	396	Shared Neighborhood Hits	71
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG8_MOUSE
NC score	0.652319 (rank : 26)	θ value	3.29651e-10 (rank : 55)
Query Neighborhood Hits	174	Target Neighborhood Hits	79	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

FGD1_HUMAN
NC score	0.641477 (rank : 27)	θ value	3.29651e-10 (rank : 56)
Query Neighborhood Hits	174	Target Neighborhood Hits	367	Shared Neighborhood Hits	74
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
NC score	0.639697 (rank : 28)	θ value	6.64225e-11 (rank : 46)
Query Neighborhood Hits	174	Target Neighborhood Hits	387	Shared Neighborhood Hits	70
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ARHGA_MOUSE
NC score	0.638874 (rank : 29)	θ value	2.13673e-09 (rank : 58)
Query Neighborhood Hits	174	Target Neighborhood Hits	125	Shared Neighborhood Hits	64
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_HUMAN
NC score	0.637444 (rank : 30)	θ value	1.133e-10 (rank : 48)
Query Neighborhood Hits	174	Target Neighborhood Hits	187	Shared Neighborhood Hits	68
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGG_HUMAN
NC score	0.636236 (rank : 31)	θ value	2.28291e-11 (rank : 45)
Query Neighborhood Hits	174	Target Neighborhood Hits	129	Shared Neighborhood Hits	67
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG6_HUMAN
NC score	0.631240 (rank : 32)	θ value	3.62785e-25 (rank : 15)
Query Neighborhood Hits	174	Target Neighborhood Hits	376	Shared Neighborhood Hits	66
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHGG_MOUSE
NC score	0.628141 (rank : 33)	θ value	2.52405e-10 (rank : 52)
Query Neighborhood Hits	174	Target Neighborhood Hits	152	Shared Neighborhood Hits	65
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG6_MOUSE
NC score	0.610553 (rank : 34)	θ value	8.93572e-24 (rank : 17)
Query Neighborhood Hits	174	Target Neighborhood Hits	394	Shared Neighborhood Hits	67
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

NGEF_HUMAN
NC score	0.608380 (rank : 35)	θ value	2.52405e-10 (rank : 54)
Query Neighborhood Hits	174	Target Neighborhood Hits	166	Shared Neighborhood Hits	68
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHG5_HUMAN
NC score	0.607299 (rank : 36)	θ value	1.43324e-05 (rank : 69)
Query Neighborhood Hits	174	Target Neighborhood Hits	172	Shared Neighborhood Hits	68
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

FGD6_MOUSE
NC score	0.607021 (rank : 37)	θ value	6.20254e-17 (rank : 26)
Query Neighborhood Hits	174	Target Neighborhood Hits	282	Shared Neighborhood Hits	66
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD6_HUMAN
NC score	0.599835 (rank : 38)	θ value	3.63628e-17 (rank : 25)
Query Neighborhood Hits	174	Target Neighborhood Hits	237	Shared Neighborhood Hits	66
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

NGEF_MOUSE
NC score	0.598989 (rank : 39)	θ value	1.133e-10 (rank : 49)
Query Neighborhood Hits	174	Target Neighborhood Hits	228	Shared Neighborhood Hits	72
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

VAV_MOUSE
NC score	0.590635 (rank : 40)	θ value	1.5242e-23 (rank : 19)
Query Neighborhood Hits	174	Target Neighborhood Hits	430	Shared Neighborhood Hits	68
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV2_MOUSE
NC score	0.589331 (rank : 41)	θ value	1.42661e-21 (rank : 20)
Query Neighborhood Hits	174	Target Neighborhood Hits	456	Shared Neighborhood Hits	70
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

DNMBP_MOUSE
NC score	0.588928 (rank : 42)	θ value	4.44505e-15 (rank : 33)
Query Neighborhood Hits	174	Target Neighborhood Hits	435	Shared Neighborhood Hits	71
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

VAV2_HUMAN
NC score	0.583724 (rank : 43)	θ value	3.17815e-21 (rank : 21)
Query Neighborhood Hits	174	Target Neighborhood Hits	453	Shared Neighborhood Hits	69
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV3_MOUSE
NC score	0.583535 (rank : 44)	θ value	3.51386e-20 (rank : 24)
Query Neighborhood Hits	174	Target Neighborhood Hits	404	Shared Neighborhood Hits	69
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV3_HUMAN
NC score	0.582019 (rank : 45)	θ value	3.51386e-20 (rank : 23)
Query Neighborhood Hits	174	Target Neighborhood Hits	398	Shared Neighborhood Hits	68
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
NC score	0.579380 (rank : 46)	θ value	4.15078e-21 (rank : 22)
Query Neighborhood Hits	174	Target Neighborhood Hits	452	Shared Neighborhood Hits	68
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

DNMBP_HUMAN
NC score	0.576718 (rank : 47)	θ value	7.58209e-15 (rank : 34)
Query Neighborhood Hits	174	Target Neighborhood Hits	413	Shared Neighborhood Hits	71
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHG1_HUMAN
NC score	0.543788 (rank : 48)	θ value	8.97725e-08 (rank : 62)
Query Neighborhood Hits	174	Target Neighborhood Hits	176	Shared Neighborhood Hits	62
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHGF_HUMAN
NC score	0.534642 (rank : 49)	θ value	3.77169e-06 (rank : 67)
Query Neighborhood Hits	174	Target Neighborhood Hits	214	Shared Neighborhood Hits	68
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGB_HUMAN
NC score	0.531266 (rank : 50)	θ value	1.63604e-09 (rank : 57)
Query Neighborhood Hits	174	Target Neighborhood Hits	375	Shared Neighborhood Hits	72
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

FARP2_MOUSE
NC score	0.504905 (rank : 51)	θ value	1.29331e-14 (rank : 36)
Query Neighborhood Hits	174	Target Neighborhood Hits	209	Shared Neighborhood Hits	72
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FGD5_HUMAN
NC score	0.504169 (rank : 52)	θ value	7.58209e-15 (rank : 35)
Query Neighborhood Hits	174	Target Neighborhood Hits	235	Shared Neighborhood Hits	49
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

ARHGC_HUMAN
NC score	0.501372 (rank : 53)	θ value	9.92553e-07 (rank : 66)
Query Neighborhood Hits	174	Target Neighborhood Hits	351	Shared Neighborhood Hits	74
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHG1_MOUSE
NC score	0.497172 (rank : 54)	θ value	1.99992e-07 (rank : 63)
Query Neighborhood Hits	174	Target Neighborhood Hits	266	Shared Neighborhood Hits	59
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_MOUSE
NC score	0.496628 (rank : 55)	θ value	0.000786445 (rank : 70)
Query Neighborhood Hits	174	Target Neighborhood Hits	120	Shared Neighborhood Hits	62
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

FGD5_MOUSE
NC score	0.488348 (rank : 56)	θ value	1.058e-16 (rank : 28)
Query Neighborhood Hits	174	Target Neighborhood Hits	170	Shared Neighborhood Hits	52
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FARP2_HUMAN
NC score	0.484203 (rank : 57)	θ value	1.16975e-15 (rank : 30)
Query Neighborhood Hits	174	Target Neighborhood Hits	240	Shared Neighborhood Hits	71
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ARHGC_MOUSE
NC score	0.476392 (rank : 58)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	174	Target Neighborhood Hits	344	Shared Neighborhood Hits	71
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ITSN2_HUMAN
NC score	0.459944 (rank : 59)	θ value	1.09485e-13 (rank : 38)
Query Neighborhood Hits	174	Target Neighborhood Hits	1173	Shared Neighborhood Hits	83
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

LBC_HUMAN
NC score	0.459788 (rank : 60)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	174	Target Neighborhood Hits	90	Shared Neighborhood Hits	58
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHG2_HUMAN
NC score	0.455496 (rank : 61)	θ value	0.0563607 (rank : 76)
Query Neighborhood Hits	174	Target Neighborhood Hits	142	Shared Neighborhood Hits	60
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

GNRP_MOUSE
NC score	0.445574 (rank : 62)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	174	Target Neighborhood Hits	191	Shared Neighborhood Hits	64
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ITSN2_MOUSE
NC score	0.434503 (rank : 63)	θ value	2.52405e-10 (rank : 53)
Query Neighborhood Hits	174	Target Neighborhood Hits	1371	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

FARP1_HUMAN
NC score	0.424123 (rank : 64)	θ value	5.81887e-07 (rank : 65)
Query Neighborhood Hits	174	Target Neighborhood Hits	241	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

ITSN1_HUMAN
NC score	0.421694 (rank : 65)	θ value	7.84624e-12 (rank : 43)
Query Neighborhood Hits	174	Target Neighborhood Hits	1757	Shared Neighborhood Hits	96
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.421002 (rank : 66)	θ value	1.33837e-11 (rank : 44)
Query Neighborhood Hits	174	Target Neighborhood Hits	1669	Shared Neighborhood Hits	102
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

RGNEF_MOUSE
NC score	0.415776 (rank : 67)	θ value	0.00298849 (rank : 71)
Query Neighborhood Hits	174	Target Neighborhood Hits	641	Shared Neighborhood Hits	71
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

GNRP_HUMAN
NC score	0.398111 (rank : 68)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	174	Target Neighborhood Hits	239	Shared Neighborhood Hits	64
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

ABR_HUMAN
NC score	0.396202 (rank : 69)	θ value	2.61198e-07 (rank : 64)
Query Neighborhood Hits	174	Target Neighborhood Hits	166	Shared Neighborhood Hits	63
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

BCR_HUMAN
NC score	0.390750 (rank : 70)	θ value	4.92598e-06 (rank : 68)
Query Neighborhood Hits	174	Target Neighborhood Hits	204	Shared Neighborhood Hits	62
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

SOS1_HUMAN
NC score	0.369424 (rank : 71)	θ value	8.67504e-11 (rank : 47)
Query Neighborhood Hits	174	Target Neighborhood Hits	274	Shared Neighborhood Hits	44
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
NC score	0.353841 (rank : 72)	θ value	1.9326e-10 (rank : 51)
Query Neighborhood Hits	174	Target Neighborhood Hits	281	Shared Neighborhood Hits	45
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS2_HUMAN
NC score	0.335330 (rank : 73)	θ value	3.64472e-09 (rank : 60)
Query Neighborhood Hits	174	Target Neighborhood Hits	193	Shared Neighborhood Hits	38
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

TRIO_HUMAN
NC score	0.276150 (rank : 74)	θ value	2.59387e-31 (rank : 4)
Query Neighborhood Hits	174	Target Neighborhood Hits	1580	Shared Neighborhood Hits	87
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

DUET_HUMAN
NC score	0.268924 (rank : 75)	θ value	9.54697e-26 (rank : 14)
Query Neighborhood Hits	174	Target Neighborhood Hits	1220	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

NCF1_HUMAN
NC score	0.203836 (rank : 76)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	174	Target Neighborhood Hits	198	Shared Neighborhood Hits	26
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

SH3K1_HUMAN
NC score	0.198659 (rank : 77)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	174	Target Neighborhood Hits	341	Shared Neighborhood Hits	27
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

PKHF2_HUMAN
NC score	0.196423 (rank : 78)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	174	Target Neighborhood Hits	75	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
NC score	0.195510 (rank : 79)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	174	Target Neighborhood Hits	77	Shared Neighborhood Hits	18
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHF1_HUMAN
NC score	0.193932 (rank : 80)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	174	Target Neighborhood Hits	76	Shared Neighborhood Hits	18
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
NC score	0.191440 (rank : 81)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	174	Target Neighborhood Hits	80	Shared Neighborhood Hits	17
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

CD2AP_HUMAN
NC score	0.189158 (rank : 82)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	174	Target Neighborhood Hits	315	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
NC score	0.187952 (rank : 83)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	174	Target Neighborhood Hits	336	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

SH3K1_MOUSE
NC score	0.187647 (rank : 84)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	174	Target Neighborhood Hits	332	Shared Neighborhood Hits	27
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

NCF1_MOUSE
NC score	0.186884 (rank : 85)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	174	Target Neighborhood Hits	198	Shared Neighborhood Hits	25
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

SRBS1_HUMAN
NC score	0.174224 (rank : 86)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	174	Target Neighborhood Hits	396	Shared Neighborhood Hits	33
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
NC score	0.171122 (rank : 87)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	174	Target Neighborhood Hits	409	Shared Neighborhood Hits	30
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

NCF2_HUMAN
NC score	0.166198 (rank : 88)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	174	Target Neighborhood Hits	229	Shared Neighborhood Hits	25
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

VINEX_MOUSE
NC score	0.164492 (rank : 89)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	174	Target Neighborhood Hits	286	Shared Neighborhood Hits	29
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

GRAP_HUMAN
NC score	0.164094 (rank : 90)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	174	Target Neighborhood Hits	307	Shared Neighborhood Hits	23
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
NC score	0.163217 (rank : 91)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	174	Target Neighborhood Hits	309	Shared Neighborhood Hits	24
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

VINEX_HUMAN
NC score	0.161820 (rank : 92)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	174	Target Neighborhood Hits	270	Shared Neighborhood Hits	27
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

NCK1_HUMAN
NC score	0.160354 (rank : 93)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	174	Target Neighborhood Hits	312	Shared Neighborhood Hits	26
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCF4_MOUSE
NC score	0.158414 (rank : 94)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	174	Target Neighborhood Hits	177	Shared Neighborhood Hits	21
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_HUMAN
NC score	0.157548 (rank : 95)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	174	Target Neighborhood Hits	161	Shared Neighborhood Hits	19
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

STAC_HUMAN
NC score	0.154865 (rank : 96)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	174	Target Neighborhood Hits	276	Shared Neighborhood Hits	26
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

NCK2_HUMAN
NC score	0.154481 (rank : 97)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	174	Target Neighborhood Hits	310	Shared Neighborhood Hits	26
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

STAC_MOUSE
NC score	0.149218 (rank : 98)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	174	Target Neighborhood Hits	268	Shared Neighborhood Hits	25
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

GRB2_HUMAN
NC score	0.148311 (rank : 99)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	174	Target Neighborhood Hits	310	Shared Neighborhood Hits	21
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.148286 (rank : 100)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	174	Target Neighborhood Hits	312	Shared Neighborhood Hits	21
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

OBSCN_HUMAN
NC score	0.143354 (rank : 101)	θ value	4.02038e-16 (rank : 29)
Query Neighborhood Hits	174	Target Neighborhood Hits	1931	Shared Neighborhood Hits	72
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

STAM1_HUMAN
NC score	0.137078 (rank : 102)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	174	Target Neighborhood Hits	271	Shared Neighborhood Hits	24
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

GRAP2_HUMAN
NC score	0.136701 (rank : 103)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	174	Target Neighborhood Hits	304	Shared Neighborhood Hits	22
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
NC score	0.136257 (rank : 104)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	174	Target Neighborhood Hits	297	Shared Neighborhood Hits	20
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

STAC3_MOUSE
NC score	0.136216 (rank : 105)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	174	Target Neighborhood Hits	232	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_HUMAN
NC score	0.135026 (rank : 106)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	174	Target Neighborhood Hits	228	Shared Neighborhood Hits	21
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

SRC8_HUMAN
NC score	0.134977 (rank : 107)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	174	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

STAM1_MOUSE
NC score	0.134812 (rank : 108)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	174	Target Neighborhood Hits	273	Shared Neighborhood Hits	23
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

HCLS1_MOUSE
NC score	0.134396 (rank : 109)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	174	Target Neighborhood Hits	329	Shared Neighborhood Hits	28
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

ABI2_HUMAN
NC score	0.133797 (rank : 110)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	174	Target Neighborhood Hits	350	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

HCLS1_HUMAN
NC score	0.133236 (rank : 111)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	174	Target Neighborhood Hits	358	Shared Neighborhood Hits	28
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

ABI2_MOUSE
NC score	0.132843 (rank : 112)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	174	Target Neighborhood Hits	266	Shared Neighborhood Hits	23
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

SRC8_MOUSE
NC score	0.132541 (rank : 113)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	174	Target Neighborhood Hits	292	Shared Neighborhood Hits	24
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

CRKL_HUMAN
NC score	0.131457 (rank : 114)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	174	Target Neighborhood Hits	313	Shared Neighborhood Hits	20
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

STAM2_MOUSE
NC score	0.129627 (rank : 115)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	174	Target Neighborhood Hits	285	Shared Neighborhood Hits	25
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

PPIP1_HUMAN
NC score	0.129265 (rank : 116)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	174	Target Neighborhood Hits	389	Shared Neighborhood Hits	31
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

SH3G3_MOUSE
NC score	0.129247 (rank : 117)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	174	Target Neighborhood Hits	236	Shared Neighborhood Hits	23
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

CRKL_MOUSE
NC score	0.129070 (rank : 118)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	174	Target Neighborhood Hits	307	Shared Neighborhood Hits	20
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

STAM2_HUMAN
NC score	0.128513 (rank : 119)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	174	Target Neighborhood Hits	288	Shared Neighborhood Hits	23
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

ABI1_MOUSE
NC score	0.126201 (rank : 120)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	174	Target Neighborhood Hits	246	Shared Neighborhood Hits	23
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

SH3G3_HUMAN
NC score	0.126165 (rank : 121)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	174	Target Neighborhood Hits	222	Shared Neighborhood Hits	22
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G1_HUMAN
NC score	0.125752 (rank : 122)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	174	Target Neighborhood Hits	307	Shared Neighborhood Hits	26
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

CRK_MOUSE
NC score	0.125248 (rank : 123)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	174	Target Neighborhood Hits	314	Shared Neighborhood Hits	22
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

PLCG1_MOUSE
NC score	0.123878 (rank : 124)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	174	Target Neighborhood Hits	314	Shared Neighborhood Hits	20
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PPIP1_MOUSE
NC score	0.123557 (rank : 125)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	174	Target Neighborhood Hits	377	Shared Neighborhood Hits	29
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PLCG1_HUMAN
NC score	0.123245 (rank : 126)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	174	Target Neighborhood Hits	293	Shared Neighborhood Hits	20
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

CRK_HUMAN
NC score	0.122285 (rank : 127)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	174	Target Neighborhood Hits	308	Shared Neighborhood Hits	21
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SH3G2_HUMAN
NC score	0.121442 (rank : 128)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	174	Target Neighborhood Hits	324	Shared Neighborhood Hits	26
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G1_MOUSE
NC score	0.121420 (rank : 129)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	174	Target Neighborhood Hits	291	Shared Neighborhood Hits	24
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

ZFYV9_HUMAN
NC score	0.121154 (rank : 130)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	174	Target Neighborhood Hits	134	Shared Neighborhood Hits	19
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

SH3G2_MOUSE
NC score	0.118473 (rank : 131)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	174	Target Neighborhood Hits	319	Shared Neighborhood Hits	26
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

ABI1_HUMAN
NC score	0.118342 (rank : 132)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	174	Target Neighborhood Hits	257	Shared Neighborhood Hits	23
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ZFY28_HUMAN
NC score	0.117831 (rank : 133)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	174	Target Neighborhood Hits	152	Shared Neighborhood Hits	16
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

BI2L1_HUMAN
NC score	0.116157 (rank : 134)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	174	Target Neighborhood Hits	156	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

ZFY16_HUMAN
NC score	0.115853 (rank : 135)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	174	Target Neighborhood Hits	125	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

OSTF1_HUMAN
NC score	0.115623 (rank : 136)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	174	Target Neighborhood Hits	466	Shared Neighborhood Hits	23
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
NC score	0.114860 (rank : 137)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	174	Target Neighborhood Hits	467	Shared Neighborhood Hits	23
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

ZFY16_MOUSE
NC score	0.114076 (rank : 138)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	174	Target Neighborhood Hits	108	Shared Neighborhood Hits	13
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

SHAN2_MOUSE
NC score	0.112438 (rank : 139)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	174	Target Neighborhood Hits	446	Shared Neighborhood Hits	33
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

AHI1_HUMAN
NC score	0.111185 (rank : 140)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	174	Target Neighborhood Hits	537	Shared Neighborhood Hits	30
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ABI3_HUMAN
NC score	0.110886 (rank : 141)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	174	Target Neighborhood Hits	227	Shared Neighborhood Hits	23
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

PLCG2_HUMAN
NC score	0.110098 (rank : 142)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	174	Target Neighborhood Hits	280	Shared Neighborhood Hits	16
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

ZFY21_MOUSE
NC score	0.109598 (rank : 143)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	174	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

DBNL_HUMAN
NC score	0.108095 (rank : 144)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	174	Target Neighborhood Hits	244	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

ZFY21_HUMAN
NC score	0.107362 (rank : 145)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	174	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

AHI1_MOUSE
NC score	0.107228 (rank : 146)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	174	Target Neighborhood Hits	496	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ABI3_MOUSE
NC score	0.106602 (rank : 147)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	174	Target Neighborhood Hits	227	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

DBNL_MOUSE
NC score	0.105470 (rank : 148)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	174	Target Neighborhood Hits	306	Shared Neighborhood Hits	22
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

NPHP1_MOUSE
NC score	0.103573 (rank : 149)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	174	Target Neighborhood Hits	267	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

SPTA2_HUMAN
NC score	0.101303 (rank : 150)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	174	Target Neighborhood Hits	888	Shared Neighborhood Hits	39
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

PEX13_MOUSE
NC score	0.099916 (rank : 151)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	174	Target Neighborhood Hits	126	Shared Neighborhood Hits	19
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

SPTA1_MOUSE
NC score	0.097753 (rank : 152)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	174	Target Neighborhood Hits	675	Shared Neighborhood Hits	35
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

PEX13_HUMAN
NC score	0.097728 (rank : 153)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	174	Target Neighborhood Hits	128	Shared Neighborhood Hits	19
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PACN2_MOUSE
NC score	0.095865 (rank : 154)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	174	Target Neighborhood Hits	382	Shared Neighborhood Hits	34
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

TCGAP_MOUSE
NC score	0.095401 (rank : 155)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	174	Target Neighborhood Hits	409	Shared Neighborhood Hits	33
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ANM2_HUMAN
NC score	0.095336 (rank : 156)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	174	Target Neighborhood Hits	175	Shared Neighborhood Hits	18
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

RHG04_HUMAN
NC score	0.094883 (rank : 157)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	174	Target Neighborhood Hits	307	Shared Neighborhood Hits	22
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

PACN2_HUMAN
NC score	0.094549 (rank : 158)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	174	Target Neighborhood Hits	339	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

LASP1_HUMAN
NC score	0.093988 (rank : 159)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	174	Target Neighborhood Hits	293	Shared Neighborhood Hits	22
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

CT032_HUMAN
NC score	0.093806 (rank : 160)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	174	Target Neighborhood Hits	235	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

LMO7_HUMAN
NC score	0.093038 (rank : 161)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	174	Target Neighborhood Hits	507	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

NOXO1_MOUSE
NC score	0.091810 (rank : 162)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	174	Target Neighborhood Hits	114	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

LASP1_MOUSE
NC score	0.091613 (rank : 163)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	174	Target Neighborhood Hits	297	Shared Neighborhood Hits	23
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

BCAR1_MOUSE
NC score	0.091363 (rank : 164)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	174	Target Neighborhood Hits	438	Shared Neighborhood Hits	22
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

RBNS5_HUMAN
NC score	0.091069 (rank : 165)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	174	Target Neighborhood Hits	242	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

BI2L1_MOUSE
NC score	0.090736 (rank : 166)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	174	Target Neighborhood Hits	197	Shared Neighborhood Hits	24
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

SHAN1_HUMAN
NC score	0.090337 (rank : 167)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	174	Target Neighborhood Hits	1041	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SPTA1_HUMAN
NC score	0.090040 (rank : 168)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	174	Target Neighborhood Hits	748	Shared Neighborhood Hits	37
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

NEBL_HUMAN
NC score	0.089593 (rank : 169)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	174	Target Neighborhood Hits	457	Shared Neighborhood Hits	29
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

BCAR1_HUMAN
NC score	0.088601 (rank : 170)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	174	Target Neighborhood Hits	554	Shared Neighborhood Hits	27
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

HGS_MOUSE
NC score	0.088569 (rank : 171)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	174	Target Neighborhood Hits	589	Shared Neighborhood Hits	25
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

HGS_HUMAN
NC score	0.088082 (rank : 172)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	174	Target Neighborhood Hits	517	Shared Neighborhood Hits	24
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

PACN3_MOUSE
NC score	0.088075 (rank : 173)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	174	Target Neighborhood Hits	380	Shared Neighborhood Hits	25
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

TCGAP_HUMAN
NC score	0.087579 (rank : 174)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	174	Target Neighborhood Hits	872	Shared Neighborhood Hits	40
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

PACN3_HUMAN
NC score	0.087426 (rank : 175)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	174	Target Neighborhood Hits	385	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

ANM2_MOUSE
NC score	0.087388 (rank : 176)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	174	Target Neighborhood Hits	175	Shared Neighborhood Hits	18
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

CASL_HUMAN
NC score	0.086771 (rank : 177)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	174	Target Neighborhood Hits	259	Shared Neighborhood Hits	25
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

RBNS5_MOUSE
NC score	0.085860 (rank : 178)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	174	Target Neighborhood Hits	266	Shared Neighborhood Hits	20
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

PACN1_HUMAN
NC score	0.085387 (rank : 179)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	174	Target Neighborhood Hits	320	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

RIMB2_HUMAN
NC score	0.084991 (rank : 180)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	174	Target Neighborhood Hits	263	Shared Neighborhood Hits	17
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
NC score	0.084593 (rank : 181)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	174	Target Neighborhood Hits	246	Shared Neighborhood Hits	21
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

PACN1_MOUSE
NC score	0.083121 (rank : 182)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	174	Target Neighborhood Hits	283	Shared Neighborhood Hits	24
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

CASL_MOUSE
NC score	0.082470 (rank : 183)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	174	Target Neighborhood Hits	225	Shared Neighborhood Hits	21
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

NEBU_HUMAN
NC score	0.080896 (rank : 184)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	174	Target Neighborhood Hits	420	Shared Neighborhood Hits	30
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

NOXO1_HUMAN
NC score	0.079555 (rank : 185)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	174	Target Neighborhood Hits	100	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

GRP3_HUMAN
NC score	0.077883 (rank : 186)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	174	Target Neighborhood Hits	131	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

NPHP1_HUMAN
NC score	0.077029 (rank : 187)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	174	Target Neighborhood Hits	288	Shared Neighborhood Hits	27
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

EFS_MOUSE
NC score	0.076426 (rank : 188)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	174	Target Neighborhood Hits	389	Shared Neighborhood Hits	26
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

IASPP_MOUSE
NC score	0.076052 (rank : 189)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	174	Target Neighborhood Hits	1024	Shared Neighborhood Hits	41
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

SRGP1_HUMAN
NC score	0.075117 (rank : 190)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	174	Target Neighborhood Hits	390	Shared Neighborhood Hits	28
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

ZFY19_HUMAN
NC score	0.074547 (rank : 191)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	174	Target Neighborhood Hits	206	Shared Neighborhood Hits	12
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

SRGP2_MOUSE
NC score	0.074350 (rank : 192)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	174	Target Neighborhood Hits	324	Shared Neighborhood Hits	24
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

FNBP2_HUMAN
NC score	0.074074 (rank : 193)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	174	Target Neighborhood Hits	432	Shared Neighborhood Hits	28
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

EFS_HUMAN
NC score	0.073913 (rank : 194)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	174	Target Neighborhood Hits	348	Shared Neighborhood Hits	24
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

SRGP2_HUMAN
NC score	0.073389 (rank : 195)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	174	Target Neighborhood Hits	331	Shared Neighborhood Hits	25
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

CNN1_HUMAN
NC score	0.073158 (rank : 196)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	174	Target Neighborhood Hits	38	Shared Neighborhood Hits	9
SwissProt Accessions	P51911, O00638, Q15416, Q8IY93, Q99438	Gene names	CNN1
Domain Architecture
Description	Calponin-1 (Calponin H1, smooth muscle) (Basic calponin).

CNN1_MOUSE
NC score	0.073031 (rank : 197)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	174	Target Neighborhood Hits	37	Shared Neighborhood Hits	9
SwissProt Accessions	Q08091	Gene names	Cnn1
Domain Architecture
Description	Calponin-1 (Calponin H1, smooth muscle) (Basic calponin).

FYV1_HUMAN
NC score	0.072713 (rank : 198)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	174	Target Neighborhood Hits	217	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

PKHA6_HUMAN
NC score	0.072578 (rank : 199)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	174	Target Neighborhood Hits	556	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

RHG26_HUMAN
NC score	0.072352 (rank : 200)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	174	Target Neighborhood Hits	281	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

CNN2_MOUSE
NC score	0.072074 (rank : 201)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	174	Target Neighborhood Hits	39	Shared Neighborhood Hits	9
SwissProt Accessions	Q08093	Gene names	Cnn2
Domain Architecture
Description	Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin).

MIA_MOUSE
NC score	0.071554 (rank : 202)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	174	Target Neighborhood Hits	17	Shared Neighborhood Hits	7
SwissProt Accessions	Q61865, O09086, P97495	Gene names	Mia, Cdrap, Mia1
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity) (Cartilage-derived retinoic acid-sensitive protein) (CD-RAP).

ASPP1_MOUSE
NC score	0.070973 (rank : 203)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	174	Target Neighborhood Hits	1244	Shared Neighborhood Hits	47
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

PKHA6_MOUSE
NC score	0.070669 (rank : 204)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	174	Target Neighborhood Hits	591	Shared Neighborhood Hits	27
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

ZFYV1_HUMAN
NC score	0.070285 (rank : 205)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	174	Target Neighborhood Hits	166	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

MIA_HUMAN
NC score	0.070058 (rank : 206)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	174	Target Neighborhood Hits	19	Shared Neighborhood Hits	8
SwissProt Accessions	Q16674	Gene names	MIA
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity).

IASPP_HUMAN
NC score	0.069639 (rank : 207)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	174	Target Neighborhood Hits	688	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

CNN3_MOUSE
NC score	0.069137 (rank : 208)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	174	Target Neighborhood Hits	45	Shared Neighborhood Hits	9
SwissProt Accessions	Q9DAW9, Q3TW23	Gene names	Cnn3
Domain Architecture	No domain graphic available
Description	Calponin-3 (Calponin, acidic isoform).

CNN3_HUMAN
NC score	0.068981 (rank : 209)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	174	Target Neighborhood Hits	43	Shared Neighborhood Hits	9
SwissProt Accessions	Q15417	Gene names	CNN3
Domain Architecture
Description	Calponin-3 (Calponin, acidic isoform).

DDEF2_MOUSE
NC score	0.068874 (rank : 210)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	174	Target Neighborhood Hits	625	Shared Neighborhood Hits	33
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_HUMAN
NC score	0.068831 (rank : 211)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	174	Target Neighborhood Hits	599	Shared Neighborhood Hits	33
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

ZFYV1_MOUSE
NC score	0.068752 (rank : 212)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	174	Target Neighborhood Hits	153	Shared Neighborhood Hits	12
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

ALS2_MOUSE
NC score	0.068120 (rank : 213)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	174	Target Neighborhood Hits	111	Shared Neighborhood Hits	17
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

ZFY19_MOUSE
NC score	0.067795 (rank : 214)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	174	Target Neighborhood Hits	143	Shared Neighborhood Hits	13
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

FYV1_MOUSE
NC score	0.067734 (rank : 215)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	174	Target Neighborhood Hits	191	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

CNN2_HUMAN
NC score	0.067529 (rank : 216)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	174	Target Neighborhood Hits	37	Shared Neighborhood Hits	9
SwissProt Accessions	Q99439, Q92578	Gene names	CNN2
Domain Architecture
Description	Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin).

SNX18_MOUSE
NC score	0.067528 (rank : 217)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	174	Target Neighborhood Hits	198	Shared Neighborhood Hits	18
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

P85B_HUMAN
NC score	0.067044 (rank : 218)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	174	Target Neighborhood Hits	543	Shared Neighborhood Hits	23
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

ASPP1_HUMAN
NC score	0.066863 (rank : 219)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	174	Target Neighborhood Hits	956	Shared Neighborhood Hits	35
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

P85A_HUMAN
NC score	0.066810 (rank : 220)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	174	Target Neighborhood Hits	479	Shared Neighborhood Hits	24
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

RUFY1_MOUSE
NC score	0.066716 (rank : 221)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	174	Target Neighborhood Hits	765	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

EEA1_MOUSE
NC score	0.066272 (rank : 222)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	174	Target Neighborhood Hits	1637	Shared Neighborhood Hits	54
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

RUFY1_HUMAN
NC score	0.066233 (rank : 223)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	174	Target Neighborhood Hits	848	Shared Neighborhood Hits	36
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

RUFY2_MOUSE
NC score	0.065971 (rank : 224)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	174	Target Neighborhood Hits	820	Shared Neighborhood Hits	37
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

SNX18_HUMAN
NC score	0.065199 (rank : 225)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	174	Target Neighborhood Hits	207	Shared Neighborhood Hits	19
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

P85B_MOUSE
NC score	0.064996 (rank : 226)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	174	Target Neighborhood Hits	519	Shared Neighborhood Hits	24
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

BAIP2_MOUSE
NC score	0.064935 (rank : 227)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	174	Target Neighborhood Hits	185	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

P85A_MOUSE
NC score	0.064754 (rank : 228)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	174	Target Neighborhood Hits	435	Shared Neighborhood Hits	22
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

BAIP2_HUMAN
NC score	0.063256 (rank : 229)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	174	Target Neighborhood Hits	192	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

RUFY2_HUMAN
NC score	0.063124 (rank : 230)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	174	Target Neighborhood Hits	1208	Shared Neighborhood Hits	43
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

MYO1F_MOUSE
NC score	0.062120 (rank : 231)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	174	Target Neighborhood Hits	262	Shared Neighborhood Hits	25
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

DDEF1_MOUSE
NC score	0.061083 (rank : 232)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	174	Target Neighborhood Hits	592	Shared Neighborhood Hits	29
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

MYO1F_HUMAN
NC score	0.061012 (rank : 233)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	174	Target Neighborhood Hits	275	Shared Neighborhood Hits	25
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

WDFY3_HUMAN
NC score	0.060971 (rank : 234)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	174	Target Neighborhood Hits	348	Shared Neighborhood Hits	17
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

MYO1E_HUMAN
NC score	0.060924 (rank : 235)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	174	Target Neighborhood Hits	293	Shared Neighborhood Hits	28
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

WDFY3_MOUSE
NC score	0.060315 (rank : 236)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	174	Target Neighborhood Hits	332	Shared Neighborhood Hits	16
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

WDFY1_HUMAN
NC score	0.060078 (rank : 237)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	174	Target Neighborhood Hits	305	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

EEA1_HUMAN
NC score	0.059872 (rank : 238)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	174	Target Neighborhood Hits	1796	Shared Neighborhood Hits	54
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

ALS2_HUMAN
NC score	0.059327 (rank : 239)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	174	Target Neighborhood Hits	121	Shared Neighborhood Hits	17
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

RIMB1_HUMAN
NC score	0.057525 (rank : 240)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	174	Target Neighborhood Hits	1479	Shared Neighborhood Hits	60
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

DSPP_MOUSE
NC score	0.057351 (rank : 241)	θ value	0.00665767 (rank : 72)
Query Neighborhood Hits	174	Target Neighborhood Hits	491	Shared Neighborhood Hits	23
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

SNX9_HUMAN
NC score	0.056955 (rank : 242)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	174	Target Neighborhood Hits	148	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

TAGL_HUMAN
NC score	0.055902 (rank : 243)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	174	Target Neighborhood Hits	32	Shared Neighborhood Hits	8
SwissProt Accessions	Q01995, O15542	Gene names	TAGLN, SM22, WS3-10
Domain Architecture
Description	Transgelin (Smooth muscle protein 22-alpha) (SM22-alpha) (WS3-10) (22 kDa actin-binding protein).

TAGL_MOUSE
NC score	0.054670 (rank : 244)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	174	Target Neighborhood Hits	33	Shared Neighborhood Hits	8
SwissProt Accessions	P37804, Q545W0	Gene names	Tagln, Sm22, Sm22a
Domain Architecture
Description	Transgelin (Smooth muscle protein 22-alpha) (SM22-alpha) (Actin- associated protein p27).

ES8L2_MOUSE
NC score	0.054653 (rank : 245)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	174	Target Neighborhood Hits	169	Shared Neighborhood Hits	18
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

SLY_MOUSE
NC score	0.054607 (rank : 246)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	174	Target Neighborhood Hits	108	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

P55G_HUMAN
NC score	0.053908 (rank : 247)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	174	Target Neighborhood Hits	451	Shared Neighborhood Hits	19
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
NC score	0.053707 (rank : 248)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	174	Target Neighborhood Hits	401	Shared Neighborhood Hits	18
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

MTMR3_HUMAN
NC score	0.053656 (rank : 249)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	174	Target Neighborhood Hits	163	Shared Neighborhood Hits	13
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

ES8L2_HUMAN
NC score	0.053230 (rank : 250)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	174	Target Neighborhood Hits	193	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

SLY_HUMAN
NC score	0.053154 (rank : 251)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	174	Target Neighborhood Hits	81	Shared Neighborhood Hits	15
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

FYCO1_MOUSE
NC score	0.053075 (rank : 252)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	174	Target Neighborhood Hits	1059	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

ASPP2_HUMAN
NC score	0.052879 (rank : 253)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	174	Target Neighborhood Hits	1156	Shared Neighborhood Hits	44
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

FYCO1_HUMAN
NC score	0.052438 (rank : 254)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	174	Target Neighborhood Hits	1149	Shared Neighborhood Hits	41
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

PKHA5_HUMAN
NC score	0.052328 (rank : 255)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	174	Target Neighborhood Hits	455	Shared Neighborhood Hits	28
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

REPS1_MOUSE
NC score	0.052293 (rank : 256)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	174	Target Neighborhood Hits	204	Shared Neighborhood Hits	15
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

EPS8_MOUSE
NC score	0.051767 (rank : 257)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	174	Target Neighborhood Hits	157	Shared Neighborhood Hits	19
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

REPS2_MOUSE
NC score	0.051557 (rank : 258)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	174	Target Neighborhood Hits	102	Shared Neighborhood Hits	7
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_HUMAN
NC score	0.051497 (rank : 259)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	174	Target Neighborhood Hits	131	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

ES8L3_HUMAN
NC score	0.050993 (rank : 260)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	174	Target Neighborhood Hits	206	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

RIMB1_MOUSE
NC score	0.050986 (rank : 261)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	174	Target Neighborhood Hits	1376	Shared Neighborhood Hits	47
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

TARA_HUMAN
NC score	0.050974 (rank : 262)	θ value	0.0431538 (rank : 75)
Query Neighborhood Hits	174	Target Neighborhood Hits	1626	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

ES8L3_MOUSE
NC score	0.050647 (rank : 263)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	174	Target Neighborhood Hits	168	Shared Neighborhood Hits	17
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

WDFY2_MOUSE
NC score	0.050337 (rank : 264)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	174	Target Neighborhood Hits	337	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

EPS8_HUMAN
NC score	0.050303 (rank : 265)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	174	Target Neighborhood Hits	151	Shared Neighborhood Hits	19
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

WDFY2_HUMAN
NC score	0.050191 (rank : 266)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	174	Target Neighborhood Hits	332	Shared Neighborhood Hits	15
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

DMP1_MOUSE
NC score	0.048509 (rank : 267)	θ value	0.0431538 (rank : 73)
Query Neighborhood Hits	174	Target Neighborhood Hits	498	Shared Neighborhood Hits	19
SwissProt Accessions	O55188	Gene names	Dmp1, Dmp
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1) (AG1).

DMP1_HUMAN
NC score	0.048067 (rank : 268)	θ value	0.21417 (rank : 82)
Query Neighborhood Hits	174	Target Neighborhood Hits	491	Shared Neighborhood Hits	23
SwissProt Accessions	Q13316, O43265	Gene names	DMP1
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1).

DSPP_HUMAN
NC score	0.044988 (rank : 269)	θ value	0.0431538 (rank : 74)
Query Neighborhood Hits	174	Target Neighborhood Hits	645	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

APC_HUMAN
NC score	0.041397 (rank : 270)	θ value	0.62314 (rank : 94)
Query Neighborhood Hits	174	Target Neighborhood Hits	603	Shared Neighborhood Hits	25
SwissProt Accessions	P25054, Q15162, Q15163, Q93042	Gene names	APC, DP2.5
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC).

FIS1_MOUSE
NC score	0.039766 (rank : 271)	θ value	1.06291 (rank : 99)
Query Neighborhood Hits	174	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CQ92	Gene names	Fis1, Ttc11
Domain Architecture	No domain graphic available
Description	Mitochondrial fission 1 protein (Fis1 homolog) (Tetratricopeptide repeat protein 11) (TPR repeat protein 11).

APC_MOUSE
NC score	0.037144 (rank : 272)	θ value	0.279714 (rank : 84)
Query Neighborhood Hits	174	Target Neighborhood Hits	441	Shared Neighborhood Hits	20
SwissProt Accessions	Q61315, Q62044	Gene names	Apc
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC) (mAPC).

AF9_HUMAN
NC score	0.035649 (rank : 273)	θ value	0.21417 (rank : 81)
Query Neighborhood Hits	174	Target Neighborhood Hits	202	Shared Neighborhood Hits	11
SwissProt Accessions	P42568	Gene names	MLLT3, AF9, YEATS3
Domain Architecture
Description	Protein AF-9 (ALL1 fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3).

CT2NL_MOUSE
NC score	0.034706 (rank : 274)	θ value	0.163984 (rank : 80)
Query Neighborhood Hits	174	Target Neighborhood Hits	902	Shared Neighborhood Hits	27
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

HMMR_MOUSE
NC score	0.033249 (rank : 275)	θ value	1.06291 (rank : 100)
Query Neighborhood Hits	174	Target Neighborhood Hits	1178	Shared Neighborhood Hits	34
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

GOGA4_HUMAN
NC score	0.032906 (rank : 276)	θ value	1.81305 (rank : 109)
Query Neighborhood Hits	174	Target Neighborhood Hits	2034	Shared Neighborhood Hits	55
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

FA13A_MOUSE
NC score	0.032877 (rank : 277)	θ value	0.0961366 (rank : 78)
Query Neighborhood Hits	174	Target Neighborhood Hits	83	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BGI4, Q8BZ91	Gene names	Fam13a1, Precm1
Domain Architecture	No domain graphic available
Description	Protein FAM13A1 (Precm1 protein).

FIS1_HUMAN
NC score	0.032843 (rank : 278)	θ value	3.0926 (rank : 124)
Query Neighborhood Hits	174	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y3D6, Q9BTP3	Gene names	FIS1, TTC11
Domain Architecture	No domain graphic available
Description	Mitochondrial fission 1 protein (Fis1 homolog) (hFis1) (Tetratricopeptide repeat protein 11) (TPR repeat protein 11).

SRRM2_HUMAN
NC score	0.032448 (rank : 279)	θ value	4.03905 (rank : 140)
Query Neighborhood Hits	174	Target Neighborhood Hits	1296	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

SRRM1_MOUSE
NC score	0.032301 (rank : 280)	θ value	0.47712 (rank : 92)
Query Neighborhood Hits	174	Target Neighborhood Hits	966	Shared Neighborhood Hits	23
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

SRRM2_MOUSE
NC score	0.031729 (rank : 281)	θ value	6.88961 (rank : 158)
Query Neighborhood Hits	174	Target Neighborhood Hits	1470	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

CT2NL_HUMAN
NC score	0.031426 (rank : 282)	θ value	2.36792 (rank : 118)
Query Neighborhood Hits	174	Target Neighborhood Hits	1059	Shared Neighborhood Hits	34
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

AKAP9_HUMAN
NC score	0.031267 (rank : 283)	θ value	0.365318 (rank : 86)
Query Neighborhood Hits	174	Target Neighborhood Hits	1710	Shared Neighborhood Hits	48
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

SRRM1_HUMAN
NC score	0.030928 (rank : 284)	θ value	0.813845 (rank : 98)
Query Neighborhood Hits	174	Target Neighborhood Hits	690	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

SEP10_MOUSE
NC score	0.030340 (rank : 285)	θ value	0.47712 (rank : 90)
Query Neighborhood Hits	174	Target Neighborhood Hits	145	Shared Neighborhood Hits	13
SwissProt Accessions	Q8C650, Q7TSA5	Gene names	Sept10
Domain Architecture	No domain graphic available
Description	Septin-10.

MYPN_HUMAN
NC score	0.029783 (rank : 286)	θ value	0.62314 (rank : 96)
Query Neighborhood Hits	174	Target Neighborhood Hits	418	Shared Neighborhood Hits	5
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

GSCR2_HUMAN
NC score	0.029459 (rank : 287)	θ value	1.81305 (rank : 110)
Query Neighborhood Hits	174	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NZM5, Q9BTC6, Q9HAX6, Q9NPP1, Q9NPR4, Q9UFI2	Gene names	GLTSCR2
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 2 protein (p60).

SEP10_HUMAN
NC score	0.028218 (rank : 288)	θ value	0.47712 (rank : 89)
Query Neighborhood Hits	174	Target Neighborhood Hits	161	Shared Neighborhood Hits	13
SwissProt Accessions	Q9P0V9, Q9HAH6	Gene names	SEPT10
Domain Architecture	No domain graphic available
Description	Septin-10.

ACINU_MOUSE
NC score	0.027841 (rank : 289)	θ value	5.27518 (rank : 143)
Query Neighborhood Hits	174	Target Neighborhood Hits	712	Shared Neighborhood Hits	29
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

AFF1_HUMAN
NC score	0.027154 (rank : 290)	θ value	1.81305 (rank : 107)
Query Neighborhood Hits	174	Target Neighborhood Hits	506	Shared Neighborhood Hits	20
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

ULA1_MOUSE
NC score	0.026838 (rank : 291)	θ value	1.38821 (rank : 106)
Query Neighborhood Hits	174	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VBW6, Q8CFL6	Gene names	Appbp1
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 regulatory subunit (Amyloid protein-binding protein 1) (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1).

SEPT6_HUMAN
NC score	0.026804 (rank : 292)	θ value	1.06291 (rank : 101)
Query Neighborhood Hits	174	Target Neighborhood Hits	220	Shared Neighborhood Hits	14
SwissProt Accessions	Q14141, Q5JTK0, Q969W5, Q96A13, Q96GR1, Q96P86, Q96P87	Gene names	SEPT6, KIAA0128, SEP2
Domain Architecture
Description	Septin-6.

ULA1_HUMAN
NC score	0.025812 (rank : 293)	θ value	1.81305 (rank : 117)
Query Neighborhood Hits	174	Target Neighborhood Hits	18	Shared Neighborhood Hits	4
SwissProt Accessions	Q13564	Gene names	APPBP1
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 regulatory subunit (Amyloid protein-binding protein 1) (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Protooncogene protein 1) (HPP1).

SEPT6_MOUSE
NC score	0.025543 (rank : 294)	θ value	3.0926 (rank : 130)
Query Neighborhood Hits	174	Target Neighborhood Hits	244	Shared Neighborhood Hits	14
SwissProt Accessions	Q9R1T4, Q91XH2, Q9CZ94	Gene names	Sept6
Domain Architecture
Description	Septin-6.

DMD_HUMAN
NC score	0.024817 (rank : 295)	θ value	3.0926 (rank : 123)
Query Neighborhood Hits	174	Target Neighborhood Hits	1135	Shared Neighborhood Hits	32
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

K0226_MOUSE
NC score	0.024314 (rank : 296)	θ value	1.81305 (rank : 112)
Query Neighborhood Hits	174	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q80U62, Q3TAX3, Q3TDF7, Q3TDU2, Q6P9T7, Q6PG18, Q8BMP7, Q8BY22	Gene names	Kiaa0226
Domain Architecture	No domain graphic available
Description	Protein KIAA0226.

NCOA6_HUMAN
NC score	0.024155 (rank : 297)	θ value	6.88961 (rank : 157)
Query Neighborhood Hits	174	Target Neighborhood Hits	1202	Shared Neighborhood Hits	35
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

TMF1_HUMAN
NC score	0.023879 (rank : 298)	θ value	1.06291 (rank : 103)
Query Neighborhood Hits	174	Target Neighborhood Hits	987	Shared Neighborhood Hits	34
SwissProt Accessions	P82094	Gene names	TMF1
Domain Architecture	No domain graphic available
Description	TATA element modulatory factor (TMF).

CENPE_HUMAN
NC score	0.023477 (rank : 299)	θ value	4.03905 (rank : 135)
Query Neighborhood Hits	174	Target Neighborhood Hits	2060	Shared Neighborhood Hits	54
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

SET1A_HUMAN
NC score	0.023466 (rank : 300)	θ value	1.06291 (rank : 102)
Query Neighborhood Hits	174	Target Neighborhood Hits	690	Shared Neighborhood Hits	26
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

SEPT8_MOUSE
NC score	0.023386 (rank : 301)	θ value	3.0926 (rank : 131)
Query Neighborhood Hits	174	Target Neighborhood Hits	251	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CHH9, Q80YC7, Q9ESF7	Gene names	Sept8, Kiaa0202
Domain Architecture
Description	Septin-8.

AFF4_MOUSE
NC score	0.023312 (rank : 302)	θ value	3.0926 (rank : 122)
Query Neighborhood Hits	174	Target Neighborhood Hits	581	Shared Neighborhood Hits	29
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

SEPT8_HUMAN
NC score	0.023297 (rank : 303)	θ value	4.03905 (rank : 139)
Query Neighborhood Hits	174	Target Neighborhood Hits	290	Shared Neighborhood Hits	14
SwissProt Accessions	Q92599, Q8IX36, Q8IX37, Q9BVB3	Gene names	SEPT8, KIAA0202
Domain Architecture
Description	Septin-8.

SI1L1_MOUSE
NC score	0.023266 (rank : 304)	θ value	0.47712 (rank : 91)
Query Neighborhood Hits	174	Target Neighborhood Hits	189	Shared Neighborhood Hits	10
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

TCF20_MOUSE
NC score	0.023186 (rank : 305)	θ value	5.27518 (rank : 149)
Query Neighborhood Hits	174	Target Neighborhood Hits	396	Shared Neighborhood Hits	30
SwissProt Accessions	Q9EPQ8, Q60792	Gene names	Tcf20, Spbp
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP).

FBX38_MOUSE
NC score	0.022746 (rank : 306)	θ value	0.813845 (rank : 97)
Query Neighborhood Hits	174	Target Neighborhood Hits	60	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BMI0, Q8BTQ4, Q8C0H4	Gene names	Fbxo38
Domain Architecture	No domain graphic available
Description	F-box only protein 38 (Modulator of KLF7 activity) (MoKA).

LZTS2_MOUSE
NC score	0.022733 (rank : 307)	θ value	1.81305 (rank : 114)
Query Neighborhood Hits	174	Target Neighborhood Hits	423	Shared Neighborhood Hits	18
SwissProt Accessions	Q91YU6, Q569X6	Gene names	Lzts2, Kiaa1813
Domain Architecture
Description	Leucine zipper putative tumor suppressor 2.

K0226_HUMAN
NC score	0.022002 (rank : 308)	θ value	3.0926 (rank : 126)
Query Neighborhood Hits	174	Target Neighborhood Hits	92	Shared Neighborhood Hits	4
SwissProt Accessions	Q92622	Gene names	KIAA0226
Domain Architecture	No domain graphic available
Description	Protein KIAA0226.

BRE1B_HUMAN
NC score	0.020943 (rank : 309)	θ value	5.27518 (rank : 145)
Query Neighborhood Hits	174	Target Neighborhood Hits	1040	Shared Neighborhood Hits	23
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

FA13A_HUMAN
NC score	0.020621 (rank : 310)	θ value	6.88961 (rank : 152)
Query Neighborhood Hits	174	Target Neighborhood Hits	102	Shared Neighborhood Hits	7
SwissProt Accessions	O94988, Q8NBA3	Gene names	FAM13A1, KIAA0914
Domain Architecture	No domain graphic available
Description	Protein FAM13A1.

K0460_HUMAN
NC score	0.020381 (rank : 311)	θ value	1.81305 (rank : 113)
Query Neighborhood Hits	174	Target Neighborhood Hits	357	Shared Neighborhood Hits	20
SwissProt Accessions	Q5VT52, O75048, Q5VT53, Q6MZL4, Q86XD2	Gene names	KIAA0460
Domain Architecture	No domain graphic available
Description	Protein KIAA0460.

DPOLL_MOUSE
NC score	0.020304 (rank : 312)	θ value	0.62314 (rank : 95)
Query Neighborhood Hits	174	Target Neighborhood Hits	71	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QXE2, Q9CTJ1	Gene names	Poll, Polk
Domain Architecture
Description	DNA polymerase lambda (EC 2.7.7.7) (EC 4.2.99.-) (Pol Lambda) (DNA polymerase kappa).

SI1L1_HUMAN
NC score	0.020221 (rank : 313)	θ value	1.38821 (rank : 105)
Query Neighborhood Hits	174	Target Neighborhood Hits	162	Shared Neighborhood Hits	6
SwissProt Accessions	O43166, O95321, Q9UDU4, Q9UNU4	Gene names	SIPA1L1, E6TP1, KIAA0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1 (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6- targeted protein 1).

TXND2_MOUSE
NC score	0.019392 (rank : 314)	θ value	4.03905 (rank : 141)
Query Neighborhood Hits	174	Target Neighborhood Hits	828	Shared Neighborhood Hits	36
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

MYST4_MOUSE
NC score	0.018481 (rank : 315)	θ value	1.38821 (rank : 104)
Query Neighborhood Hits	174	Target Neighborhood Hits	416	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BRB7, Q7TNW5, Q8BG35, Q8C441, Q9JKX5	Gene names	Myst4
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Querkopf protein).

MYST4_HUMAN
NC score	0.017970 (rank : 316)	θ value	1.81305 (rank : 115)
Query Neighborhood Hits	174	Target Neighborhood Hits	671	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

CTR9_MOUSE
NC score	0.017956 (rank : 317)	θ value	8.99809 (rank : 165)
Query Neighborhood Hits	174	Target Neighborhood Hits	427	Shared Neighborhood Hits	24
SwissProt Accessions	Q62018, Q3UFF5, Q3UY40, Q66JX4, Q7TPS6, Q8BND9, Q8BRD1, Q8C9W7, Q8C9Y3, Q8CHI1	Gene names	Ctr9, Kiaa0155, Sh2bp1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) (Tetratricopeptide repeat-containing, SH2-binding phosphoprotein of 150 kDa) (TPR-containing, SH2-binding phosphoprotein of 150 kDa) (p150TSP).

IF140_HUMAN
NC score	0.017240 (rank : 318)	θ value	3.0926 (rank : 125)
Query Neighborhood Hits	174	Target Neighborhood Hits	111	Shared Neighborhood Hits	2
SwissProt Accessions	Q96RY7, O60332	Gene names	IFT140, KIAA0590, WDTC2
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 140 homolog (WD and tetratricopeptide repeats protein 2).

2A5D_HUMAN
NC score	0.017071 (rank : 319)	θ value	0.62314 (rank : 93)
Query Neighborhood Hits	174	Target Neighborhood Hits	59	Shared Neighborhood Hits	6
SwissProt Accessions	Q14738, O00494, O00696, Q15171	Gene names	PPP2R5D
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A, B subunit, B' delta isoform) (PP2A, B subunit, B56 delta isoform) (PP2A, B subunit, PR61 delta isoform) (PP2A, B subunit, R5 delta isoform).

MYH11_HUMAN
NC score	0.016680 (rank : 320)	θ value	2.36792 (rank : 119)
Query Neighborhood Hits	174	Target Neighborhood Hits	1806	Shared Neighborhood Hits	44
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

CABIN_HUMAN
NC score	0.016487 (rank : 321)	θ value	4.03905 (rank : 133)
Query Neighborhood Hits	174	Target Neighborhood Hits	490	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

RSU1_MOUSE
NC score	0.016435 (rank : 322)	θ value	0.125558 (rank : 79)
Query Neighborhood Hits	174	Target Neighborhood Hits	239	Shared Neighborhood Hits	3
SwissProt Accessions	Q01730	Gene names	Rsu1, Rsp1
Domain Architecture	No domain graphic available
Description	Ras suppressor protein 1 (Rsu-1) (RSP-1).

RSU1_HUMAN
NC score	0.016138 (rank : 323)	θ value	0.0736092 (rank : 77)
Query Neighborhood Hits	174	Target Neighborhood Hits	250	Shared Neighborhood Hits	3
SwissProt Accessions	Q15404	Gene names	RSU1, RSP1
Domain Architecture
Description	Ras suppressor protein 1 (Rsu-1) (RSP-1).

NOL4_MOUSE
NC score	0.015794 (rank : 324)	θ value	2.36792 (rank : 120)
Query Neighborhood Hits	174	Target Neighborhood Hits	44	Shared Neighborhood Hits	4
SwissProt Accessions	P60954	Gene names	Nol4
Domain Architecture	No domain graphic available
Description	Nucleolar protein 4.

4ET_HUMAN
NC score	0.015697 (rank : 325)	θ value	5.27518 (rank : 142)
Query Neighborhood Hits	174	Target Neighborhood Hits	96	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NRA8, Q8NCF2, Q9H708	Gene names	EIF4ENIF1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4E transporter (eIF4E transporter) (4E-T) (Eukaryotic translation initiation factor 4E nuclear import factor 1).

PROM1_MOUSE
NC score	0.015605 (rank : 326)	θ value	4.03905 (rank : 136)
Query Neighborhood Hits	174	Target Neighborhood Hits	77	Shared Neighborhood Hits	8
SwissProt Accessions	O54990, O35408	Gene names	Prom1, Prom, Proml1
Domain Architecture
Description	Prominin-1 precursor (Prominin-like protein 1) (Antigen AC133 homolog).

TRH_HUMAN
NC score	0.015507 (rank : 327)	θ value	8.99809 (rank : 173)
Query Neighborhood Hits	174	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	P20396, Q2TB83	Gene names	TRH
Domain Architecture
Description	Thyroliberin precursor [Contains: Prothyroliberin; Thyroliberin (Thyrotropin-releasing hormone) (TRH) (Thyrotropin-releasing factor) (TRF) (TSH-releasing factor) (Protirelin)].

MYH11_MOUSE
NC score	0.015265 (rank : 328)	θ value	6.88961 (rank : 156)
Query Neighborhood Hits	174	Target Neighborhood Hits	1777	Shared Neighborhood Hits	37
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MAST1_HUMAN
NC score	0.015239 (rank : 329)	θ value	0.279714 (rank : 85)
Query Neighborhood Hits	174	Target Neighborhood Hits	1146	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

TR240_HUMAN
NC score	0.015016 (rank : 330)	θ value	2.36792 (rank : 121)
Query Neighborhood Hits	174	Target Neighborhood Hits	99	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UHV7, O60334	Gene names	THRAP1, ARC250, KIAA0593, TRAP240
Domain Architecture
Description	Thyroid hormone receptor-associated protein complex 240 kDa component (Trap240) (Thyroid hormone receptor-associated protein 1) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP 250) (Activator-recruited cofactor 250 kDa component) (ARC250).

MUC1_MOUSE
NC score	0.014308 (rank : 331)	θ value	6.88961 (rank : 155)
Query Neighborhood Hits	174	Target Neighborhood Hits	388	Shared Neighborhood Hits	12
SwissProt Accessions	Q02496	Gene names	Muc1, Muc-1
Domain Architecture
Description	Mucin-1 precursor (Polymorphic epithelial mucin) (PEMT) (Episialin).

BRCA2_MOUSE
NC score	0.013826 (rank : 332)	θ value	4.03905 (rank : 132)
Query Neighborhood Hits	174	Target Neighborhood Hits	222	Shared Neighborhood Hits	11
SwissProt Accessions	P97929, O35922, P97383	Gene names	Brca2, Fancd1
Domain Architecture
Description	Breast cancer type 2 susceptibility protein homolog (Fanconi anemia group D1 protein homolog).

STAG3_MOUSE
NC score	0.013824 (rank : 333)	θ value	1.81305 (rank : 116)
Query Neighborhood Hits	174	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	O70576	Gene names	Stag3
Domain Architecture
Description	Cohesin subunit SA-3 (Stromal antigen 3) (Stromalin 3) (SCC3 homolog 3).

B2L12_HUMAN
NC score	0.013128 (rank : 334)	θ value	8.99809 (rank : 163)
Query Neighborhood Hits	174	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HB09, Q3SY11, Q96I96, Q9HB08	Gene names	BCL2L12, BPR
Domain Architecture	No domain graphic available
Description	Bcl-2-related proline-rich protein (Bcl-2-like 12 protein).

STAG3_HUMAN
NC score	0.012901 (rank : 335)	θ value	8.99809 (rank : 172)
Query Neighborhood Hits	174	Target Neighborhood Hits	41	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UJ98, Q8NDP3	Gene names	STAG3
Domain Architecture
Description	Cohesin subunit SA-3 (Stromal antigen 3) (Stromalin 3) (SCC3 homolog 3).

CHD9_MOUSE
NC score	0.012824 (rank : 336)	θ value	0.47712 (rank : 88)
Query Neighborhood Hits	174	Target Neighborhood Hits	427	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BYH8, Q7TMV5, Q8BJG8, Q8BZJ2, Q8CHG8	Gene names	Chd9, Kiaa0308, Pric320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha- interacting complex protein 320 kDa).

SETX_HUMAN
NC score	0.012556 (rank : 337)	θ value	8.99809 (rank : 171)
Query Neighborhood Hits	174	Target Neighborhood Hits	368	Shared Neighborhood Hits	21
SwissProt Accessions	Q7Z333, O75120, Q3KQX4, Q68DW5, Q6AZD7, Q7Z3J6, Q8WX33, Q9H9D1, Q9NVP9	Gene names	SETX, ALS4, KIAA0625, SCAR1
Domain Architecture
Description	Probable helicase senataxin (EC 3.6.1.-) (SEN1 homolog).

PSG9_HUMAN
NC score	0.012466 (rank : 338)	θ value	3.0926 (rank : 127)
Query Neighborhood Hits	174	Target Neighborhood Hits	221	Shared Neighborhood Hits	5
SwissProt Accessions	Q00887, Q15236, Q15237, Q8WW78, Q9UQ73	Gene names	PSG9, PSG11
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 9 precursor (PSBG-9) (Pregnancy-specific glycoprotein 9) (Pregnancy-specific beta-1 glycoprotein B) (PS-beta-B) (PS34) (Pregnancy-specific glycoprotein 7) (PSG7).

SETBP_HUMAN
NC score	0.012379 (rank : 339)	θ value	8.99809 (rank : 170)
Query Neighborhood Hits	174	Target Neighborhood Hits	305	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y6X0, Q9UEF3	Gene names	SETBP1, KIAA0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

RNF12_MOUSE
NC score	0.011685 (rank : 340)	θ value	3.0926 (rank : 128)
Query Neighborhood Hits	174	Target Neighborhood Hits	159	Shared Neighborhood Hits	8
SwissProt Accessions	Q9WTV7	Gene names	Rnf12, Rlim
Domain Architecture
Description	RING finger protein 12 (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM).

SAPS1_MOUSE
NC score	0.011045 (rank : 341)	θ value	3.0926 (rank : 129)
Query Neighborhood Hits	174	Target Neighborhood Hits	144	Shared Neighborhood Hits	10
SwissProt Accessions	Q7TSI3, Q80TJ4	Gene names	Saps1, Kiaa1115
Domain Architecture	No domain graphic available
Description	SAPS domain family member 1.

PSG10_HUMAN
NC score	0.010833 (rank : 342)	θ value	4.03905 (rank : 137)
Query Neighborhood Hits	174	Target Neighborhood Hits	227	Shared Neighborhood Hits	5
SwissProt Accessions	Q15235, O75244, Q15224	Gene names	PSG10, PSG12
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 10 precursor (PSBG-10) (PSBG- 12).

PSG6_HUMAN
NC score	0.010767 (rank : 343)	θ value	4.03905 (rank : 138)
Query Neighborhood Hits	174	Target Neighborhood Hits	231	Shared Neighborhood Hits	5
SwissProt Accessions	Q00889	Gene names	PSG6, CGM3, PSGGB
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 6 precursor (PSBG-6).

GNAI2_HUMAN
NC score	0.010452 (rank : 344)	θ value	0.365318 (rank : 87)
Query Neighborhood Hits	174	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	P04899, Q8IZ71	Gene names	GNAI2
Domain Architecture
Description	Guanine nucleotide-binding protein G(i), alpha-2 subunit (Adenylate cyclase-inhibiting G alpha protein).

CASQ1_HUMAN
NC score	0.010272 (rank : 345)	θ value	4.03905 (rank : 134)
Query Neighborhood Hits	174	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	P31415, Q8TBW7	Gene names	CASQ1, CASQ
Domain Architecture
Description	Calsequestrin-1 precursor (Calsequestrin, skeletal muscle isoform) (Calmitin).

VDP_MOUSE
NC score	0.009616 (rank : 346)	θ value	8.99809 (rank : 174)
Query Neighborhood Hits	174	Target Neighborhood Hits	469	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Z1Z0, Q3T9L9, Q3TH58, Q3U1C7, Q3UMW6, Q91WE7, Q99JZ5	Gene names	Vdp
Domain Architecture	No domain graphic available
Description	General vesicular transport factor p115 (Transcytosis-associated protein) (TAP) (Vesicle docking protein).

LPIN1_MOUSE
NC score	0.009335 (rank : 347)	θ value	5.27518 (rank : 148)
Query Neighborhood Hits	174	Target Neighborhood Hits	85	Shared Neighborhood Hits	9
SwissProt Accessions	Q91ZP3, Q9CQI2, Q9JLG6	Gene names	Lpin1, Fld
Domain Architecture
Description	Lipin-1 (Fatty liver dystrophy protein).

JADE3_MOUSE
NC score	0.008956 (rank : 348)	θ value	5.27518 (rank : 147)
Query Neighborhood Hits	174	Target Neighborhood Hits	174	Shared Neighborhood Hits	13
SwissProt Accessions	Q6IE82, Q6ZQG2	Gene names	Phf16, Jade3, Kiaa0215
Domain Architecture	No domain graphic available
Description	Protein Jade-3 (PHD finger protein 16).

UBP42_HUMAN
NC score	0.008914 (rank : 349)	θ value	5.27518 (rank : 150)
Query Neighborhood Hits	174	Target Neighborhood Hits	445	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

LAMA2_HUMAN
NC score	0.008721 (rank : 350)	θ value	0.21417 (rank : 83)
Query Neighborhood Hits	174	Target Neighborhood Hits	1092	Shared Neighborhood Hits	14
SwissProt Accessions	P24043, Q14736, Q93022	Gene names	LAMA2, LAMM
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

GNAI2_MOUSE
NC score	0.008422 (rank : 351)	θ value	1.81305 (rank : 108)
Query Neighborhood Hits	174	Target Neighborhood Hits	70	Shared Neighborhood Hits	3
SwissProt Accessions	P08752, Q6P1C0	Gene names	Gnai2, Gnai-2
Domain Architecture
Description	Guanine nucleotide-binding protein G(i), alpha-2 subunit (Adenylate cyclase-inhibiting G alpha protein).

BNIPL_MOUSE
NC score	0.008148 (rank : 352)	θ value	5.27518 (rank : 144)
Query Neighborhood Hits	174	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q99JU7, Q923E3	Gene names	Bnipl
Domain Architecture	No domain graphic available
Description	Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein.

CHD2_HUMAN
NC score	0.007477 (rank : 353)	θ value	8.99809 (rank : 164)
Query Neighborhood Hits	174	Target Neighborhood Hits	360	Shared Neighborhood Hits	15
SwissProt Accessions	O14647	Gene names	CHD2
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 2 (EC 3.6.1.-) (ATP- dependent helicase CHD2) (CHD-2).

WDR22_HUMAN
NC score	0.007317 (rank : 354)	θ value	5.27518 (rank : 151)
Query Neighborhood Hits	174	Target Neighborhood Hits	328	Shared Neighborhood Hits	12
SwissProt Accessions	Q96JK2, O60559, Q8N3V3, Q8N3V5	Gene names	WDR22, BCRG2, KIAA1824
Domain Architecture
Description	WD repeat protein 22 (Breakpoint cluster region protein 2) (BCRP2).

KS6B2_HUMAN
NC score	0.007192 (rank : 355)	θ value	8.99809 (rank : 167)
Query Neighborhood Hits	174	Target Neighborhood Hits	858	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

PELP1_MOUSE
NC score	0.006770 (rank : 356)	θ value	8.99809 (rank : 168)
Query Neighborhood Hits	174	Target Neighborhood Hits	709	Shared Neighborhood Hits	18
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

IQGA2_HUMAN
NC score	0.005787 (rank : 357)	θ value	8.99809 (rank : 166)
Query Neighborhood Hits	174	Target Neighborhood Hits	200	Shared Neighborhood Hits	9
SwissProt Accessions	Q13576	Gene names	IQGAP2
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP2.

UBP37_HUMAN
NC score	0.005618 (rank : 358)	θ value	6.88961 (rank : 160)
Query Neighborhood Hits	174	Target Neighborhood Hits	208	Shared Neighborhood Hits	11
SwissProt Accessions	Q86T82, Q9HCH8	Gene names	USP37, KIAA1594
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.1.2.15) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37) (Deubiquitinating enzyme 37).

ST2B1_MOUSE
NC score	0.003481 (rank : 359)	θ value	6.88961 (rank : 159)
Query Neighborhood Hits	174	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	O35400, Q8K472, Q91V03	Gene names	Sult2b1, Sult2b
Domain Architecture	No domain graphic available
Description	Sulfotransferase family cytosolic 2B member 1 (EC 2.8.2.2) (Sulfotransferase 2B1) (Sulfotransferase 2B) (Alcohol sulfotransferase) (Hydroxysteroid sulfotransferase 2).

BRWD1_HUMAN
NC score	0.002432 (rank : 360)	θ value	5.27518 (rank : 146)
Query Neighborhood Hits	174	Target Neighborhood Hits	448	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NSI6, O43721, Q5R2V0, Q5R2V1, Q8TCV3, Q96QG9, Q96QH0, Q9NUK1	Gene names	BRWD1, C21orf107, WDR9
Domain Architecture
Description	Bromodomain and WD repeat domain-containing protein 1 (WD repeat protein 9).

INSM1_HUMAN
NC score	0.001789 (rank : 361)	θ value	1.81305 (rank : 111)
Query Neighborhood Hits	174	Target Neighborhood Hits	683	Shared Neighborhood Hits	4
SwissProt Accessions	Q01101	Gene names	INSM1, IA1
Domain Architecture	No domain graphic available
Description	Insulinoma-associated protein 1 (Zinc finger protein IA-1).

FOXN3_HUMAN
NC score	0.001697 (rank : 362)	θ value	6.88961 (rank : 153)
Query Neighborhood Hits	174	Target Neighborhood Hits	121	Shared Neighborhood Hits	3
SwissProt Accessions	O00409, Q96II7, Q9UIE7	Gene names	CHES1, FOXN3
Domain Architecture
Description	Checkpoint suppressor 1 (Forkhead box protein N3).

ABTB2_MOUSE
NC score	0.001188 (rank : 363)	θ value	8.99809 (rank : 162)
Query Neighborhood Hits	174	Target Neighborhood Hits	414	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TQI7	Gene names	Abtb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

ABTB2_HUMAN
NC score	0.001177 (rank : 364)	θ value	8.99809 (rank : 161)
Query Neighborhood Hits	174	Target Neighborhood Hits	391	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N961, Q6MZW4, Q8NB44	Gene names	ABTB2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

INSM1_MOUSE
NC score	0.000076 (rank : 365)	θ value	6.88961 (rank : 154)
Query Neighborhood Hits	174	Target Neighborhood Hits	678	Shared Neighborhood Hits	4
SwissProt Accessions	Q63ZV0, Q9Z113	Gene names	Insm1, Ia1
Domain Architecture	No domain graphic available
Description	Insulinoma-associated protein 1 (Zinc finger protein IA-1).

PRDM2_HUMAN
NC score	-0.003219 (rank : 366)	θ value	8.99809 (rank : 169)
Query Neighborhood Hits	174	Target Neighborhood Hits	1135	Shared Neighborhood Hits	14
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).