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Network neighborhood for query Sequence : FARP2_MOUSE

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FARP2_MOUSE
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

FARP1_HUMAN
θ value	0 (rank : 1)	NC score	0.977847 (rank : 3)
Query Neighborhood Hits	209	Target Neighborhood Hits	241	Shared Neighborhood Hits	153
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FARP2_HUMAN
θ value	0 (rank : 2)	NC score	0.989644 (rank : 2)
Query Neighborhood Hits	209	Target Neighborhood Hits	240	Shared Neighborhood Hits	164
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	209	Target Neighborhood Hits	209	Shared Neighborhood Hits	209
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

PTN4_HUMAN
θ value	4.51533e-76 (rank : 4)	NC score	0.543994 (rank : 43)
Query Neighborhood Hits	209	Target Neighborhood Hits	303	Shared Neighborhood Hits	50
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

E41L3_HUMAN
θ value	2.3998e-69 (rank : 5)	NC score	0.770864 (rank : 4)
Query Neighborhood Hits	209	Target Neighborhood Hits	113	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

E41L3_MOUSE
θ value	3.13423e-69 (rank : 6)	NC score	0.759544 (rank : 14)
Query Neighborhood Hits	209	Target Neighborhood Hits	250	Shared Neighborhood Hits	49
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

41_HUMAN
θ value	1.31681e-67 (rank : 7)	NC score	0.766288 (rank : 7)
Query Neighborhood Hits	209	Target Neighborhood Hits	157	Shared Neighborhood Hits	48
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

E41L2_HUMAN
θ value	5.53243e-66 (rank : 8)	NC score	0.755250 (rank : 16)
Query Neighborhood Hits	209	Target Neighborhood Hits	287	Shared Neighborhood Hits	49
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41L1_HUMAN
θ value	9.43692e-66 (rank : 9)	NC score	0.761267 (rank : 13)
Query Neighborhood Hits	209	Target Neighborhood Hits	180	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L1_MOUSE
θ value	2.10232e-65 (rank : 10)	NC score	0.765233 (rank : 9)
Query Neighborhood Hits	209	Target Neighborhood Hits	106	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L2_MOUSE
θ value	6.76295e-64 (rank : 11)	NC score	0.740137 (rank : 18)
Query Neighborhood Hits	209	Target Neighborhood Hits	459	Shared Neighborhood Hits	56
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

41_MOUSE
θ value	3.71096e-62 (rank : 12)	NC score	0.763174 (rank : 12)
Query Neighborhood Hits	209	Target Neighborhood Hits	184	Shared Neighborhood Hits	51
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

E41L5_HUMAN
θ value	1.0458e-56 (rank : 13)	NC score	0.768659 (rank : 5)
Query Neighborhood Hits	209	Target Neighborhood Hits	76	Shared Neighborhood Hits	47
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

E41LB_MOUSE
θ value	3.1488e-53 (rank : 14)	NC score	0.768215 (rank : 6)
Query Neighborhood Hits	209	Target Neighborhood Hits	59	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

E41LB_HUMAN
θ value	7.75577e-52 (rank : 15)	NC score	0.763501 (rank : 10)
Query Neighborhood Hits	209	Target Neighborhood Hits	79	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

PTN3_HUMAN
θ value	3.98324e-48 (rank : 16)	NC score	0.519509 (rank : 45)
Query Neighborhood Hits	209	Target Neighborhood Hits	258	Shared Neighborhood Hits	49
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

FGD4_MOUSE
θ value	3.72821e-46 (rank : 17)	NC score	0.585772 (rank : 31)
Query Neighborhood Hits	209	Target Neighborhood Hits	227	Shared Neighborhood Hits	96
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FRMD5_MOUSE
θ value	6.35935e-46 (rank : 18)	NC score	0.765744 (rank : 8)
Query Neighborhood Hits	209	Target Neighborhood Hits	55	Shared Neighborhood Hits	48
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

FRMD5_HUMAN
θ value	1.08474e-45 (rank : 19)	NC score	0.763408 (rank : 11)
Query Neighborhood Hits	209	Target Neighborhood Hits	55	Shared Neighborhood Hits	48
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

FGD4_HUMAN
θ value	2.41655e-45 (rank : 20)	NC score	0.586028 (rank : 30)
Query Neighborhood Hits	209	Target Neighborhood Hits	219	Shared Neighborhood Hits	98
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

E41LA_HUMAN
θ value	5.95217e-44 (rank : 21)	NC score	0.756131 (rank : 15)
Query Neighborhood Hits	209	Target Neighborhood Hits	87	Shared Neighborhood Hits	48
SwissProt Accessions	Q9HCS5	Gene names	EPB41L4A, EPB41L4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

FGD6_HUMAN
θ value	9.50281e-42 (rank : 22)	NC score	0.553023 (rank : 41)
Query Neighborhood Hits	209	Target Neighborhood Hits	237	Shared Neighborhood Hits	99
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

E41LA_MOUSE
θ value	3.61106e-41 (rank : 23)	NC score	0.754809 (rank : 17)
Query Neighborhood Hits	209	Target Neighborhood Hits	85	Shared Neighborhood Hits	49
SwissProt Accessions	P52963	Gene names	Epb41l4a, Epb4.1l4, Epb4.1l4a, Epb41l4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

FGD6_MOUSE
θ value	1.79215e-40 (rank : 24)	NC score	0.558066 (rank : 39)
Query Neighborhood Hits	209	Target Neighborhood Hits	282	Shared Neighborhood Hits	103
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD1_MOUSE
θ value	9.83387e-39 (rank : 25)	NC score	0.571431 (rank : 35)
Query Neighborhood Hits	209	Target Neighborhood Hits	387	Shared Neighborhood Hits	93
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_HUMAN
θ value	2.19075e-38 (rank : 26)	NC score	0.574343 (rank : 34)
Query Neighborhood Hits	209	Target Neighborhood Hits	367	Shared Neighborhood Hits	96
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

RADI_HUMAN
θ value	3.61944e-33 (rank : 27)	NC score	0.588438 (rank : 29)
Query Neighborhood Hits	209	Target Neighborhood Hits	741	Shared Neighborhood Hits	65
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

RADI_MOUSE
θ value	3.61944e-33 (rank : 28)	NC score	0.584868 (rank : 32)
Query Neighborhood Hits	209	Target Neighborhood Hits	773	Shared Neighborhood Hits	65
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

FGD5_HUMAN
θ value	8.91499e-32 (rank : 29)	NC score	0.501109 (rank : 49)
Query Neighborhood Hits	209	Target Neighborhood Hits	235	Shared Neighborhood Hits	72
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD2_MOUSE
θ value	1.16434e-31 (rank : 30)	NC score	0.569012 (rank : 37)
Query Neighborhood Hits	209	Target Neighborhood Hits	163	Shared Neighborhood Hits	88
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

MOES_MOUSE
θ value	1.16434e-31 (rank : 31)	NC score	0.547007 (rank : 42)
Query Neighborhood Hits	209	Target Neighborhood Hits	923	Shared Neighborhood Hits	70
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MOES_HUMAN
θ value	1.52067e-31 (rank : 32)	NC score	0.553469 (rank : 40)
Query Neighborhood Hits	209	Target Neighborhood Hits	892	Shared Neighborhood Hits	70
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

FGD3_HUMAN
θ value	1.6813e-30 (rank : 33)	NC score	0.566456 (rank : 38)
Query Neighborhood Hits	209	Target Neighborhood Hits	249	Shared Neighborhood Hits	76
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

PTN21_MOUSE
θ value	8.3442e-30 (rank : 34)	NC score	0.495403 (rank : 52)
Query Neighborhood Hits	209	Target Neighborhood Hits	155	Shared Neighborhood Hits	46
SwissProt Accessions	Q62136	Gene names	Ptpn21
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-RL10).

EZRI_MOUSE
θ value	1.4233e-29 (rank : 35)	NC score	0.597323 (rank : 28)
Query Neighborhood Hits	209	Target Neighborhood Hits	693	Shared Neighborhood Hits	66
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

FGD2_HUMAN
θ value	1.85889e-29 (rank : 36)	NC score	0.569556 (rank : 36)
Query Neighborhood Hits	209	Target Neighborhood Hits	151	Shared Neighborhood Hits	87
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

EZRI_HUMAN
θ value	3.17079e-29 (rank : 37)	NC score	0.600077 (rank : 27)
Query Neighborhood Hits	209	Target Neighborhood Hits	663	Shared Neighborhood Hits	64
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

PTN21_HUMAN
θ value	5.40856e-29 (rank : 38)	NC score	0.493797 (rank : 53)
Query Neighborhood Hits	209	Target Neighborhood Hits	143	Shared Neighborhood Hits	46
SwissProt Accessions	Q16825	Gene names	PTPN21, PTPD1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1).

MERL_HUMAN
θ value	1.2049e-28 (rank : 39)	NC score	0.629336 (rank : 26)
Query Neighborhood Hits	209	Target Neighborhood Hits	532	Shared Neighborhood Hits	61
SwissProt Accessions	P35240, O95683, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4	Gene names	NF2, SCH
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Schwannomerlin).

MERL_MOUSE
θ value	1.57365e-28 (rank : 40)	NC score	0.629989 (rank : 25)
Query Neighborhood Hits	209	Target Neighborhood Hits	524	Shared Neighborhood Hits	62
SwissProt Accessions	P46662, Q8BR03	Gene names	Nf2, Nf-2
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin).

FGD3_MOUSE
θ value	5.06226e-27 (rank : 41)	NC score	0.575865 (rank : 33)
Query Neighborhood Hits	209	Target Neighborhood Hits	257	Shared Neighborhood Hits	92
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD5_MOUSE
θ value	1.92365e-26 (rank : 42)	NC score	0.491085 (rank : 54)
Query Neighborhood Hits	209	Target Neighborhood Hits	170	Shared Neighborhood Hits	78
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

ARHG4_HUMAN
θ value	3.62785e-25 (rank : 43)	NC score	0.499779 (rank : 50)
Query Neighborhood Hits	209	Target Neighborhood Hits	242	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PTN14_MOUSE
θ value	8.08199e-25 (rank : 44)	NC score	0.478873 (rank : 58)
Query Neighborhood Hits	209	Target Neighborhood Hits	142	Shared Neighborhood Hits	46
SwissProt Accessions	Q62130	Gene names	Ptpn14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP36).

MYLIP_HUMAN
θ value	1.05554e-24 (rank : 45)	NC score	0.683992 (rank : 20)
Query Neighborhood Hits	209	Target Neighborhood Hits	162	Shared Neighborhood Hits	44
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

PTN14_HUMAN
θ value	2.35151e-24 (rank : 46)	NC score	0.473060 (rank : 59)
Query Neighborhood Hits	209	Target Neighborhood Hits	163	Shared Neighborhood Hits	47
SwissProt Accessions	Q15678	Gene names	PTPN14, PEZ
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez).

ARHG4_MOUSE
θ value	5.23862e-24 (rank : 47)	NC score	0.511200 (rank : 46)
Query Neighborhood Hits	209	Target Neighborhood Hits	185	Shared Neighborhood Hits	70
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

MYLIP_MOUSE
θ value	5.23862e-24 (rank : 48)	NC score	0.695217 (rank : 19)
Query Neighborhood Hits	209	Target Neighborhood Hits	139	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

PREX1_HUMAN
θ value	7.0802e-21 (rank : 49)	NC score	0.533522 (rank : 44)
Query Neighborhood Hits	209	Target Neighborhood Hits	177	Shared Neighborhood Hits	80
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PTN13_MOUSE
θ value	1.5773e-20 (rank : 50)	NC score	0.381305 (rank : 77)
Query Neighborhood Hits	209	Target Neighborhood Hits	426	Shared Neighborhood Hits	52
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

FRM4A_MOUSE
θ value	3.51386e-20 (rank : 51)	NC score	0.634023 (rank : 23)
Query Neighborhood Hits	209	Target Neighborhood Hits	108	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BIE6, Q6PDJ4, Q8CHA6	Gene names	Frmd4a, Frmd4, Kiaa1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

PTN13_HUMAN
θ value	3.51386e-20 (rank : 52)	NC score	0.374707 (rank : 80)
Query Neighborhood Hits	209	Target Neighborhood Hits	471	Shared Neighborhood Hits	56
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

FRM4A_HUMAN
θ value	1.02238e-19 (rank : 53)	NC score	0.632588 (rank : 24)
Query Neighborhood Hits	209	Target Neighborhood Hits	110	Shared Neighborhood Hits	48
SwissProt Accessions	Q9P2Q2	Gene names	FRMD4A, FRMD4, KIAA1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

FRM4B_HUMAN
θ value	1.24977e-17 (rank : 54)	NC score	0.638033 (rank : 21)
Query Neighborhood Hits	209	Target Neighborhood Hits	117	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y2L6, Q8TAI3	Gene names	FRMD4B, KIAA1013
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1).

FRM4B_MOUSE
θ value	2.13179e-17 (rank : 55)	NC score	0.636075 (rank : 22)
Query Neighborhood Hits	209	Target Neighborhood Hits	109	Shared Neighborhood Hits	49
SwissProt Accessions	Q920B0, Q3V1S1, Q9ESP9	Gene names	Frmd4b
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1) (Golgi- associated band 4.1-like protein) (GOBLIN).

ARHG9_HUMAN
θ value	6.20254e-17 (rank : 56)	NC score	0.482878 (rank : 55)
Query Neighborhood Hits	209	Target Neighborhood Hits	235	Shared Neighborhood Hits	71
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	6.20254e-17 (rank : 57)	NC score	0.481913 (rank : 56)
Query Neighborhood Hits	209	Target Neighborhood Hits	234	Shared Neighborhood Hits	71
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG7_HUMAN
θ value	3.07829e-16 (rank : 58)	NC score	0.392429 (rank : 70)
Query Neighborhood Hits	209	Target Neighborhood Hits	347	Shared Neighborhood Hits	80
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ITSN1_HUMAN
θ value	4.44505e-15 (rank : 59)	NC score	0.289343 (rank : 113)
Query Neighborhood Hits	209	Target Neighborhood Hits	1757	Shared Neighborhood Hits	102
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

PKHG1_HUMAN
θ value	1.29331e-14 (rank : 60)	NC score	0.504905 (rank : 47)
Query Neighborhood Hits	209	Target Neighborhood Hits	174	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ITSN1_MOUSE
θ value	6.41864e-14 (rank : 61)	NC score	0.291455 (rank : 112)
Query Neighborhood Hits	209	Target Neighborhood Hits	1669	Shared Neighborhood Hits	101
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

DUET_HUMAN
θ value	8.38298e-14 (rank : 62)	NC score	0.152120 (rank : 130)
Query Neighborhood Hits	209	Target Neighborhood Hits	1220	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

ARHG6_MOUSE
θ value	4.16044e-13 (rank : 63)	NC score	0.340634 (rank : 90)
Query Neighborhood Hits	209	Target Neighborhood Hits	394	Shared Neighborhood Hits	68
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

TRIO_HUMAN
θ value	4.16044e-13 (rank : 64)	NC score	0.147592 (rank : 132)
Query Neighborhood Hits	209	Target Neighborhood Hits	1580	Shared Neighborhood Hits	96
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

ARHG7_MOUSE
θ value	4.59992e-12 (rank : 65)	NC score	0.375481 (rank : 79)
Query Neighborhood Hits	209	Target Neighborhood Hits	396	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ITSN2_HUMAN
θ value	4.59992e-12 (rank : 66)	NC score	0.304678 (rank : 101)
Query Neighborhood Hits	209	Target Neighborhood Hits	1173	Shared Neighborhood Hits	90
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	4.59992e-12 (rank : 67)	NC score	0.297919 (rank : 106)
Query Neighborhood Hits	209	Target Neighborhood Hits	1371	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ARHG6_HUMAN
θ value	1.33837e-11 (rank : 68)	NC score	0.351602 (rank : 86)
Query Neighborhood Hits	209	Target Neighborhood Hits	376	Shared Neighborhood Hits	67
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

GNRP_MOUSE
θ value	5.08577e-11 (rank : 69)	NC score	0.386464 (rank : 73)
Query Neighborhood Hits	209	Target Neighborhood Hits	191	Shared Neighborhood Hits	90
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ARHGG_MOUSE
θ value	6.64225e-11 (rank : 70)	NC score	0.439345 (rank : 63)
Query Neighborhood Hits	209	Target Neighborhood Hits	152	Shared Neighborhood Hits	66
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG2_MOUSE
θ value	8.67504e-11 (rank : 71)	NC score	0.385166 (rank : 74)
Query Neighborhood Hits	209	Target Neighborhood Hits	120	Shared Neighborhood Hits	62
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

DNMBP_MOUSE
θ value	1.133e-10 (rank : 72)	NC score	0.344498 (rank : 88)
Query Neighborhood Hits	209	Target Neighborhood Hits	435	Shared Neighborhood Hits	76
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

NGEF_MOUSE
θ value	1.47974e-10 (rank : 73)	NC score	0.424657 (rank : 66)
Query Neighborhood Hits	209	Target Neighborhood Hits	228	Shared Neighborhood Hits	70
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

GNRP_HUMAN
θ value	1.9326e-10 (rank : 74)	NC score	0.345352 (rank : 87)
Query Neighborhood Hits	209	Target Neighborhood Hits	239	Shared Neighborhood Hits	90
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

ABR_HUMAN
θ value	2.52405e-10 (rank : 75)	NC score	0.297544 (rank : 108)
Query Neighborhood Hits	209	Target Neighborhood Hits	166	Shared Neighborhood Hits	72
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

NGEF_HUMAN
θ value	2.52405e-10 (rank : 76)	NC score	0.431108 (rank : 64)
Query Neighborhood Hits	209	Target Neighborhood Hits	166	Shared Neighborhood Hits	69
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

TIAM1_HUMAN
θ value	2.52405e-10 (rank : 77)	NC score	0.423822 (rank : 68)
Query Neighborhood Hits	209	Target Neighborhood Hits	225	Shared Neighborhood Hits	78
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHGG_HUMAN
θ value	3.29651e-10 (rank : 78)	NC score	0.445598 (rank : 62)
Query Neighborhood Hits	209	Target Neighborhood Hits	129	Shared Neighborhood Hits	68
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ECT2_MOUSE
θ value	3.29651e-10 (rank : 79)	NC score	0.479712 (rank : 57)
Query Neighborhood Hits	209	Target Neighborhood Hits	98	Shared Neighborhood Hits	72
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHG2_HUMAN
θ value	9.59137e-10 (rank : 80)	NC score	0.332994 (rank : 91)
Query Neighborhood Hits	209	Target Neighborhood Hits	142	Shared Neighborhood Hits	59
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ECT2_HUMAN
θ value	1.25267e-09 (rank : 81)	NC score	0.470893 (rank : 60)
Query Neighborhood Hits	209	Target Neighborhood Hits	98	Shared Neighborhood Hits	73
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

DNMBP_HUMAN
θ value	1.63604e-09 (rank : 82)	NC score	0.327288 (rank : 94)
Query Neighborhood Hits	209	Target Neighborhood Hits	413	Shared Neighborhood Hits	72
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHGB_HUMAN
θ value	3.64472e-09 (rank : 83)	NC score	0.363509 (rank : 83)
Query Neighborhood Hits	209	Target Neighborhood Hits	375	Shared Neighborhood Hits	73
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

PKHA6_HUMAN
θ value	4.76016e-09 (rank : 84)	NC score	0.221997 (rank : 123)
Query Neighborhood Hits	209	Target Neighborhood Hits	556	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

ARHG5_HUMAN
θ value	6.21693e-09 (rank : 85)	NC score	0.430869 (rank : 65)
Query Neighborhood Hits	209	Target Neighborhood Hits	172	Shared Neighborhood Hits	69
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

PKHF2_HUMAN
θ value	8.11959e-09 (rank : 86)	NC score	0.323219 (rank : 95)
Query Neighborhood Hits	209	Target Neighborhood Hits	75	Shared Neighborhood Hits	28
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	8.11959e-09 (rank : 87)	NC score	0.322777 (rank : 96)
Query Neighborhood Hits	209	Target Neighborhood Hits	77	Shared Neighborhood Hits	31
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHA6_MOUSE
θ value	1.06045e-08 (rank : 88)	NC score	0.231827 (rank : 121)
Query Neighborhood Hits	209	Target Neighborhood Hits	591	Shared Neighborhood Hits	74
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

TIAM1_MOUSE
θ value	3.08544e-08 (rank : 89)	NC score	0.424331 (rank : 67)
Query Neighborhood Hits	209	Target Neighborhood Hits	205	Shared Neighborhood Hits	79
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

VAV3_MOUSE
θ value	4.0297e-08 (rank : 90)	NC score	0.298214 (rank : 105)
Query Neighborhood Hits	209	Target Neighborhood Hits	404	Shared Neighborhood Hits	70
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

PKHF1_HUMAN
θ value	5.26297e-08 (rank : 91)	NC score	0.315221 (rank : 98)
Query Neighborhood Hits	209	Target Neighborhood Hits	76	Shared Neighborhood Hits	24
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

BCR_HUMAN
θ value	6.87365e-08 (rank : 92)	NC score	0.296469 (rank : 110)
Query Neighborhood Hits	209	Target Neighborhood Hits	204	Shared Neighborhood Hits	71
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

PKHA5_HUMAN
θ value	8.97725e-08 (rank : 93)	NC score	0.178290 (rank : 124)
Query Neighborhood Hits	209	Target Neighborhood Hits	455	Shared Neighborhood Hits	63
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHF1_MOUSE
θ value	8.97725e-08 (rank : 94)	NC score	0.315443 (rank : 97)
Query Neighborhood Hits	209	Target Neighborhood Hits	80	Shared Neighborhood Hits	27
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

SOS1_HUMAN
θ value	1.53129e-07 (rank : 95)	NC score	0.243744 (rank : 119)
Query Neighborhood Hits	209	Target Neighborhood Hits	274	Shared Neighborhood Hits	49
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

HAPIP_HUMAN
θ value	5.81887e-07 (rank : 96)	NC score	0.359903 (rank : 85)
Query Neighborhood Hits	209	Target Neighborhood Hits	350	Shared Neighborhood Hits	76
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

MCF2_HUMAN
θ value	5.81887e-07 (rank : 97)	NC score	0.408765 (rank : 69)
Query Neighborhood Hits	209	Target Neighborhood Hits	166	Shared Neighborhood Hits	71
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

PKHA2_MOUSE
θ value	7.59969e-07 (rank : 98)	NC score	0.169918 (rank : 126)
Query Neighborhood Hits	209	Target Neighborhood Hits	116	Shared Neighborhood Hits	48
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

VAV3_HUMAN
θ value	9.92553e-07 (rank : 99)	NC score	0.293993 (rank : 111)
Query Neighborhood Hits	209	Target Neighborhood Hits	398	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ARHG8_HUMAN
θ value	1.29631e-06 (rank : 100)	NC score	0.387137 (rank : 71)
Query Neighborhood Hits	209	Target Neighborhood Hits	85	Shared Neighborhood Hits	67
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

SOS2_HUMAN
θ value	2.21117e-06 (rank : 101)	NC score	0.232096 (rank : 120)
Query Neighborhood Hits	209	Target Neighborhood Hits	193	Shared Neighborhood Hits	49
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SOS1_MOUSE
θ value	3.77169e-06 (rank : 102)	NC score	0.230223 (rank : 122)
Query Neighborhood Hits	209	Target Neighborhood Hits	281	Shared Neighborhood Hits	48
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

VAV_HUMAN
θ value	6.43352e-06 (rank : 103)	NC score	0.297793 (rank : 107)
Query Neighborhood Hits	209	Target Neighborhood Hits	452	Shared Neighborhood Hits	70
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

PLEK_HUMAN
θ value	1.09739e-05 (rank : 104)	NC score	0.143285 (rank : 134)
Query Neighborhood Hits	209	Target Neighborhood Hits	110	Shared Neighborhood Hits	45
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

VAV_MOUSE
θ value	1.09739e-05 (rank : 105)	NC score	0.304060 (rank : 102)
Query Neighborhood Hits	209	Target Neighborhood Hits	430	Shared Neighborhood Hits	71
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ARHG8_MOUSE
θ value	1.43324e-05 (rank : 106)	NC score	0.361490 (rank : 84)
Query Neighborhood Hits	209	Target Neighborhood Hits	79	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

MCF2L_MOUSE
θ value	1.87187e-05 (rank : 107)	NC score	0.376570 (rank : 78)
Query Neighborhood Hits	209	Target Neighborhood Hits	255	Shared Neighborhood Hits	70
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

VAV2_MOUSE
θ value	2.44474e-05 (rank : 108)	NC score	0.300127 (rank : 104)
Query Neighborhood Hits	209	Target Neighborhood Hits	456	Shared Neighborhood Hits	74
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

RGNEF_MOUSE
θ value	3.19293e-05 (rank : 109)	NC score	0.301117 (rank : 103)
Query Neighborhood Hits	209	Target Neighborhood Hits	641	Shared Neighborhood Hits	75
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

VAV2_HUMAN
θ value	3.19293e-05 (rank : 110)	NC score	0.297155 (rank : 109)
Query Neighborhood Hits	209	Target Neighborhood Hits	453	Shared Neighborhood Hits	75
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ARHGC_HUMAN
θ value	4.1701e-05 (rank : 111)	NC score	0.332660 (rank : 92)
Query Neighborhood Hits	209	Target Neighborhood Hits	351	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

PKHA2_HUMAN
θ value	4.1701e-05 (rank : 112)	NC score	0.157581 (rank : 128)
Query Neighborhood Hits	209	Target Neighborhood Hits	119	Shared Neighborhood Hits	45
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PLEK_MOUSE
θ value	5.44631e-05 (rank : 113)	NC score	0.135878 (rank : 138)
Query Neighborhood Hits	209	Target Neighborhood Hits	109	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

ARHGC_MOUSE
θ value	7.1131e-05 (rank : 114)	NC score	0.329590 (rank : 93)
Query Neighborhood Hits	209	Target Neighborhood Hits	344	Shared Neighborhood Hits	71
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

FRMD6_MOUSE
θ value	0.000121331 (rank : 115)	NC score	0.504555 (rank : 48)
Query Neighborhood Hits	209	Target Neighborhood Hits	63	Shared Neighborhood Hits	42
SwissProt Accessions	Q8C0V9, Q8BW34	Gene names	Frmd6
Domain Architecture
Description	FERM domain-containing protein 6.

ARHGF_HUMAN
θ value	0.000158464 (rank : 116)	NC score	0.382561 (rank : 75)
Query Neighborhood Hits	209	Target Neighborhood Hits	214	Shared Neighborhood Hits	71
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

PKHA4_MOUSE
θ value	0.000270298 (rank : 117)	NC score	0.175194 (rank : 125)
Query Neighborhood Hits	209	Target Neighborhood Hits	202	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

ALS2_HUMAN
θ value	0.00035302 (rank : 118)	NC score	0.112810 (rank : 142)
Query Neighborhood Hits	209	Target Neighborhood Hits	121	Shared Neighborhood Hits	30
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

ARHG3_HUMAN
θ value	0.00035302 (rank : 119)	NC score	0.366047 (rank : 81)
Query Neighborhood Hits	209	Target Neighborhood Hits	82	Shared Neighborhood Hits	64
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	0.000602161 (rank : 120)	NC score	0.365744 (rank : 82)
Query Neighborhood Hits	209	Target Neighborhood Hits	85	Shared Neighborhood Hits	64
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

FRMD6_HUMAN
θ value	0.00102713 (rank : 121)	NC score	0.496219 (rank : 51)
Query Neighborhood Hits	209	Target Neighborhood Hits	60	Shared Neighborhood Hits	42
SwissProt Accessions	Q96NE9, Q5HYF2, Q8N2X1, Q8WUH7	Gene names	FRMD6, C14orf31
Domain Architecture
Description	FERM domain-containing protein 6 (Willin).

PKHA1_HUMAN
θ value	0.00102713 (rank : 122)	NC score	0.124735 (rank : 140)
Query Neighborhood Hits	209	Target Neighborhood Hits	127	Shared Neighborhood Hits	43
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	0.00134147 (rank : 123)	NC score	0.125039 (rank : 139)
Query Neighborhood Hits	209	Target Neighborhood Hits	120	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHG4_HUMAN
θ value	0.00134147 (rank : 124)	NC score	0.344046 (rank : 89)
Query Neighborhood Hits	209	Target Neighborhood Hits	200	Shared Neighborhood Hits	60
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

ARHGA_HUMAN
θ value	0.00175202 (rank : 125)	NC score	0.386676 (rank : 72)
Query Neighborhood Hits	209	Target Neighborhood Hits	187	Shared Neighborhood Hits	70
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

C43BP_HUMAN
θ value	0.00175202 (rank : 126)	NC score	0.098478 (rank : 156)
Query Neighborhood Hits	209	Target Neighborhood Hits	87	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

C43BP_MOUSE
θ value	0.00175202 (rank : 127)	NC score	0.099995 (rank : 155)
Query Neighborhood Hits	209	Target Neighborhood Hits	91	Shared Neighborhood Hits	32
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

PKHA4_HUMAN
θ value	0.00390308 (rank : 128)	NC score	0.162790 (rank : 127)
Query Neighborhood Hits	209	Target Neighborhood Hits	283	Shared Neighborhood Hits	54
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

ARHGA_MOUSE
θ value	0.00665767 (rank : 129)	NC score	0.381949 (rank : 76)
Query Neighborhood Hits	209	Target Neighborhood Hits	125	Shared Neighborhood Hits	64
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

CYH3_MOUSE
θ value	0.00665767 (rank : 130)	NC score	0.104492 (rank : 150)
Query Neighborhood Hits	209	Target Neighborhood Hits	148	Shared Neighborhood Hits	56
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

ALS2_MOUSE
θ value	0.0148317 (rank : 131)	NC score	0.107001 (rank : 149)
Query Neighborhood Hits	209	Target Neighborhood Hits	111	Shared Neighborhood Hits	28
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

TLN1_HUMAN
θ value	0.0148317 (rank : 132)	NC score	0.285589 (rank : 115)
Query Neighborhood Hits	209	Target Neighborhood Hits	218	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

CNKR1_HUMAN
θ value	0.0330416 (rank : 133)	NC score	0.120322 (rank : 141)
Query Neighborhood Hits	209	Target Neighborhood Hits	154	Shared Neighborhood Hits	39
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

BSN_HUMAN
θ value	0.0431538 (rank : 134)	NC score	0.038186 (rank : 333)
Query Neighborhood Hits	209	Target Neighborhood Hits	1537	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CYH3_HUMAN
θ value	0.0431538 (rank : 135)	NC score	0.093335 (rank : 168)
Query Neighborhood Hits	209	Target Neighborhood Hits	137	Shared Neighborhood Hits	49
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

K1802_MOUSE
θ value	0.0431538 (rank : 136)	NC score	0.014545 (rank : 351)
Query Neighborhood Hits	209	Target Neighborhood Hits	1596	Shared Neighborhood Hits	37
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

TLN1_MOUSE
θ value	0.0431538 (rank : 137)	NC score	0.281457 (rank : 116)
Query Neighborhood Hits	209	Target Neighborhood Hits	213	Shared Neighborhood Hits	47
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

ZIMP7_MOUSE
θ value	0.0563607 (rank : 138)	NC score	0.026433 (rank : 340)
Query Neighborhood Hits	209	Target Neighborhood Hits	566	Shared Neighborhood Hits	16
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

RGS3_MOUSE
θ value	0.0961366 (rank : 139)	NC score	0.031344 (rank : 336)
Query Neighborhood Hits	209	Target Neighborhood Hits	1621	Shared Neighborhood Hits	42
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

ANK3_HUMAN
θ value	0.125558 (rank : 140)	NC score	0.003327 (rank : 371)
Query Neighborhood Hits	209	Target Neighborhood Hits	853	Shared Neighborhood Hits	16
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

MOK_MOUSE
θ value	0.125558 (rank : 141)	NC score	-0.002090 (rank : 376)
Query Neighborhood Hits	209	Target Neighborhood Hits	796	Shared Neighborhood Hits	5
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

K1914_HUMAN
θ value	0.163984 (rank : 142)	NC score	0.062332 (rank : 277)
Query Neighborhood Hits	209	Target Neighborhood Hits	255	Shared Neighborhood Hits	26
SwissProt Accessions	Q8N4X5, Q8TB54, Q96PX4, Q96SY5	Gene names	KIAA1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

3BP2_HUMAN
θ value	0.21417 (rank : 143)	NC score	0.100647 (rank : 153)
Query Neighborhood Hits	209	Target Neighborhood Hits	296	Shared Neighborhood Hits	40
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

CO002_HUMAN
θ value	0.21417 (rank : 144)	NC score	0.020711 (rank : 347)
Query Neighborhood Hits	209	Target Neighborhood Hits	387	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NZP6	Gene names	C15orf2
Domain Architecture	No domain graphic available
Description	Protein C15orf2.

CYH2_HUMAN
θ value	0.21417 (rank : 145)	NC score	0.087413 (rank : 184)
Query Neighborhood Hits	209	Target Neighborhood Hits	175	Shared Neighborhood Hits	55
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	0.21417 (rank : 146)	NC score	0.087416 (rank : 183)
Query Neighborhood Hits	209	Target Neighborhood Hits	171	Shared Neighborhood Hits	55
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

OSBL9_HUMAN
θ value	0.21417 (rank : 147)	NC score	0.066960 (rank : 253)
Query Neighborhood Hits	209	Target Neighborhood Hits	138	Shared Neighborhood Hits	39
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

3BP2_MOUSE
θ value	0.279714 (rank : 148)	NC score	0.103099 (rank : 151)
Query Neighborhood Hits	209	Target Neighborhood Hits	142	Shared Neighborhood Hits	41
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

CNKR2_HUMAN
θ value	0.279714 (rank : 149)	NC score	0.107696 (rank : 148)
Query Neighborhood Hits	209	Target Neighborhood Hits	197	Shared Neighborhood Hits	42
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	0.279714 (rank : 150)	NC score	0.107958 (rank : 147)
Query Neighborhood Hits	209	Target Neighborhood Hits	197	Shared Neighborhood Hits	43
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CT075_MOUSE
θ value	0.365318 (rank : 151)	NC score	0.005524 (rank : 367)
Query Neighborhood Hits	209	Target Neighborhood Hits	358	Shared Neighborhood Hits	6
SwissProt Accessions	P59383	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf75 homolog precursor.

CYH4_HUMAN
θ value	0.365318 (rank : 152)	NC score	0.088438 (rank : 181)
Query Neighborhood Hits	209	Target Neighborhood Hits	135	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

RHG25_MOUSE
θ value	0.365318 (rank : 153)	NC score	0.068906 (rank : 244)
Query Neighborhood Hits	209	Target Neighborhood Hits	492	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

CYH4_MOUSE
θ value	0.47712 (rank : 154)	NC score	0.091029 (rank : 175)
Query Neighborhood Hits	209	Target Neighborhood Hits	134	Shared Neighborhood Hits	53
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

RHG25_HUMAN
θ value	0.47712 (rank : 155)	NC score	0.069964 (rank : 241)
Query Neighborhood Hits	209	Target Neighborhood Hits	550	Shared Neighborhood Hits	61
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

CYH1_HUMAN
θ value	0.62314 (rank : 156)	NC score	0.088851 (rank : 179)
Query Neighborhood Hits	209	Target Neighborhood Hits	184	Shared Neighborhood Hits	58
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
θ value	0.62314 (rank : 157)	NC score	0.086502 (rank : 190)
Query Neighborhood Hits	209	Target Neighborhood Hits	176	Shared Neighborhood Hits	55
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

IQEC3_HUMAN
θ value	0.813845 (rank : 158)	NC score	0.051687 (rank : 317)
Query Neighborhood Hits	209	Target Neighborhood Hits	125	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

NPTX2_HUMAN
θ value	0.813845 (rank : 159)	NC score	0.011381 (rank : 356)
Query Neighborhood Hits	209	Target Neighborhood Hits	86	Shared Neighborhood Hits	3
SwissProt Accessions	P47972, Q86XV7, Q96G70	Gene names	NPTX2
Domain Architecture
Description	Neuronal pentraxin-2 precursor (NP2) (Neuronal pentraxin II) (NP-II).

TLN2_HUMAN
θ value	0.813845 (rank : 160)	NC score	0.271969 (rank : 118)
Query Neighborhood Hits	209	Target Neighborhood Hits	157	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y4G6	Gene names	TLN2, KIAA0320
Domain Architecture
Description	Talin-2.

CEND3_HUMAN
θ value	1.06291 (rank : 161)	NC score	0.038470 (rank : 332)
Query Neighborhood Hits	209	Target Neighborhood Hits	275	Shared Neighborhood Hits	41
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

DYNA_HUMAN
θ value	1.06291 (rank : 162)	NC score	0.023358 (rank : 344)
Query Neighborhood Hits	209	Target Neighborhood Hits	1194	Shared Neighborhood Hits	44
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

PLXA1_MOUSE
θ value	1.06291 (rank : 163)	NC score	0.003677 (rank : 369)
Query Neighborhood Hits	209	Target Neighborhood Hits	107	Shared Neighborhood Hits	4
SwissProt Accessions	P70206, Q5DTR0	Gene names	Plxna1, KIAA4053
Domain Architecture	No domain graphic available
Description	Plexin-A1 precursor (Plexin-1) (Plex 1).

STK10_HUMAN
θ value	1.06291 (rank : 164)	NC score	0.011275 (rank : 358)
Query Neighborhood Hits	209	Target Neighborhood Hits	1921	Shared Neighborhood Hits	44
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

TLN2_MOUSE
θ value	1.06291 (rank : 165)	NC score	0.274653 (rank : 117)
Query Neighborhood Hits	209	Target Neighborhood Hits	149	Shared Neighborhood Hits	46
SwissProt Accessions	Q71LX4, Q8BWK0	Gene names	Tln2
Domain Architecture	No domain graphic available
Description	Talin-2.

CEND3_MOUSE
θ value	1.38821 (rank : 166)	NC score	0.036976 (rank : 334)
Query Neighborhood Hits	209	Target Neighborhood Hits	228	Shared Neighborhood Hits	35
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

TCF20_MOUSE
θ value	1.38821 (rank : 167)	NC score	0.022683 (rank : 345)
Query Neighborhood Hits	209	Target Neighborhood Hits	396	Shared Neighborhood Hits	25
SwissProt Accessions	Q9EPQ8, Q60792	Gene names	Tcf20, Spbp
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP).

TRIM7_HUMAN
θ value	1.38821 (rank : 168)	NC score	0.003599 (rank : 370)
Query Neighborhood Hits	209	Target Neighborhood Hits	336	Shared Neighborhood Hits	6
SwissProt Accessions	Q9C029, Q969F5, Q96F67, Q96J89, Q96J90	Gene names	TRIM7, GNIP, RNF90
Domain Architecture
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein) (RING finger protein 90).

YETS2_MOUSE
θ value	1.38821 (rank : 169)	NC score	0.009197 (rank : 361)
Query Neighborhood Hits	209	Target Neighborhood Hits	278	Shared Neighborhood Hits	8
SwissProt Accessions	Q3TUF7, Q6PGF8, Q80TI2, Q8CG86	Gene names	Yeats2, Kiaa1197
Domain Architecture	No domain graphic available
Description	YEATS domain-containing protein 2.

ZN516_MOUSE
θ value	1.38821 (rank : 170)	NC score	-0.004701 (rank : 378)
Query Neighborhood Hits	209	Target Neighborhood Hits	1197	Shared Neighborhood Hits	17
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

ACOT2_HUMAN
θ value	1.81305 (rank : 171)	NC score	0.011321 (rank : 357)
Query Neighborhood Hits	209	Target Neighborhood Hits	15	Shared Neighborhood Hits	5
SwissProt Accessions	P49753, Q9NUX4	Gene names	ACOT2, PTE2, PTE2A
Domain Architecture
Description	Acyl-coenzyme A thioesterase 2 (EC 3.1.2.2) (Acyl-CoA thioesterase 2) (Peroxisomal acyl-coenzyme A thioester hydrolase 2a) (Peroxisomal long-chain acyl-coA thioesterase 2) (ZAP128) (CTE-Ia).

COIA1_MOUSE
θ value	1.81305 (rank : 172)	NC score	0.002884 (rank : 374)
Query Neighborhood Hits	209	Target Neighborhood Hits	481	Shared Neighborhood Hits	13
SwissProt Accessions	P39061, Q60672, Q61437, Q62001, Q62002, Q9JK63	Gene names	Col18a1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

K1914_MOUSE
θ value	1.81305 (rank : 173)	NC score	0.046434 (rank : 327)
Query Neighborhood Hits	209	Target Neighborhood Hits	216	Shared Neighborhood Hits	23
SwissProt Accessions	Q5DTU0, Q8BID1, Q8K2G0	Gene names	Kiaa1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

PHLB2_MOUSE
θ value	1.81305 (rank : 174)	NC score	0.049854 (rank : 325)
Query Neighborhood Hits	209	Target Neighborhood Hits	1016	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

CEND1_HUMAN
θ value	2.36792 (rank : 175)	NC score	0.052219 (rank : 316)
Query Neighborhood Hits	209	Target Neighborhood Hits	284	Shared Neighborhood Hits	54
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

SON_HUMAN
θ value	2.36792 (rank : 176)	NC score	0.011792 (rank : 354)
Query Neighborhood Hits	209	Target Neighborhood Hits	1568	Shared Neighborhood Hits	45
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

ANK2_HUMAN
θ value	3.0926 (rank : 177)	NC score	0.011682 (rank : 355)
Query Neighborhood Hits	209	Target Neighborhood Hits	1615	Shared Neighborhood Hits	49
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

ARNT_MOUSE
θ value	3.0926 (rank : 178)	NC score	0.003282 (rank : 372)
Query Neighborhood Hits	209	Target Neighborhood Hits	213	Shared Neighborhood Hits	9
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

BSN_MOUSE
θ value	3.0926 (rank : 179)	NC score	0.029310 (rank : 337)
Query Neighborhood Hits	209	Target Neighborhood Hits	2057	Shared Neighborhood Hits	57
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CEND1_MOUSE
θ value	3.0926 (rank : 180)	NC score	0.045184 (rank : 329)
Query Neighborhood Hits	209	Target Neighborhood Hits	260	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

NPTX2_MOUSE
θ value	3.0926 (rank : 181)	NC score	0.009398 (rank : 360)
Query Neighborhood Hits	209	Target Neighborhood Hits	79	Shared Neighborhood Hits	3
SwissProt Accessions	O70340	Gene names	Nptx2
Domain Architecture
Description	Neuronal pentraxin-2 precursor (NP2) (Neuronal pentraxin II) (NP-II).

NUF2_HUMAN
θ value	3.0926 (rank : 182)	NC score	0.012599 (rank : 353)
Query Neighborhood Hits	209	Target Neighborhood Hits	661	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BZD4, Q8WU69, Q96HJ4, Q96Q78	Gene names	CDCA1, NUF2, NUF2R
Domain Architecture	No domain graphic available
Description	Kinetochore protein Nuf2 (hNuf2) (hNuf2R) (hsNuf2) (Cell division cycle-associated protein 1).

RASA3_MOUSE
θ value	3.0926 (rank : 183)	NC score	0.024080 (rank : 343)
Query Neighborhood Hits	209	Target Neighborhood Hits	144	Shared Neighborhood Hits	26
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

SRRM2_HUMAN
θ value	3.0926 (rank : 184)	NC score	0.025554 (rank : 342)
Query Neighborhood Hits	209	Target Neighborhood Hits	1296	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

STAP2_MOUSE
θ value	3.0926 (rank : 185)	NC score	0.022052 (rank : 346)
Query Neighborhood Hits	209	Target Neighborhood Hits	41	Shared Neighborhood Hits	8
SwissProt Accessions	Q8R0L1, Q8BWS2	Gene names	Stap2
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 2 (STAP-2).

TCF20_HUMAN
θ value	3.0926 (rank : 186)	NC score	0.013084 (rank : 352)
Query Neighborhood Hits	209	Target Neighborhood Hits	323	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UGU0, O14528, Q13078, Q4V353, Q9H4M0	Gene names	TCF20, KIAA0292, SPBP
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP) (AR1).

TPR_HUMAN
θ value	3.0926 (rank : 187)	NC score	0.028588 (rank : 338)
Query Neighborhood Hits	209	Target Neighborhood Hits	1921	Shared Neighborhood Hits	63
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

CCD21_MOUSE
θ value	4.03905 (rank : 188)	NC score	0.036593 (rank : 335)
Query Neighborhood Hits	209	Target Neighborhood Hits	1135	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

IQEC3_MOUSE
θ value	4.03905 (rank : 189)	NC score	0.041826 (rank : 331)
Query Neighborhood Hits	209	Target Neighborhood Hits	274	Shared Neighborhood Hits	24
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

JHD3B_HUMAN
θ value	4.03905 (rank : 190)	NC score	0.006207 (rank : 365)
Query Neighborhood Hits	209	Target Neighborhood Hits	128	Shared Neighborhood Hits	10
SwissProt Accessions	O94953, O75274, Q6P3R5, Q9P1V1, Q9UF40	Gene names	JMJD2B, JHDM3B, KIAA0876
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3B (EC 1.14.11.-) (Jumonji domain-containing protein 2B).

RASA3_HUMAN
θ value	4.03905 (rank : 191)	NC score	0.026049 (rank : 341)
Query Neighborhood Hits	209	Target Neighborhood Hits	166	Shared Neighborhood Hits	31
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

SPTA2_HUMAN
θ value	4.03905 (rank : 192)	NC score	0.045741 (rank : 328)
Query Neighborhood Hits	209	Target Neighborhood Hits	888	Shared Neighborhood Hits	47
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

TXLNG_HUMAN
θ value	4.03905 (rank : 193)	NC score	0.005307 (rank : 368)
Query Neighborhood Hits	209	Target Neighborhood Hits	568	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NUQ3, Q9P0X1	Gene names	TXLNG, CXorf15, LSR5
Domain Architecture	No domain graphic available
Description	Gamma-taxilin (Lipopolysaccharide-specific response protein 5).

NF2L2_MOUSE
θ value	5.27518 (rank : 194)	NC score	0.006497 (rank : 363)
Query Neighborhood Hits	209	Target Neighborhood Hits	183	Shared Neighborhood Hits	6
SwissProt Accessions	Q60795	Gene names	Nfe2l2, Nrf-2, Nrf2
Domain Architecture
Description	Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nuclear factor, erythroid derived 2, like 2).

PHLB2_HUMAN
θ value	5.27518 (rank : 195)	NC score	0.047825 (rank : 326)
Query Neighborhood Hits	209	Target Neighborhood Hits	964	Shared Neighborhood Hits	60
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

STK31_HUMAN
θ value	5.27518 (rank : 196)	NC score	0.016510 (rank : 350)
Query Neighborhood Hits	209	Target Neighborhood Hits	570	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

TARA_HUMAN
θ value	5.27518 (rank : 197)	NC score	0.027403 (rank : 339)
Query Neighborhood Hits	209	Target Neighborhood Hits	1626	Shared Neighborhood Hits	64
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TTC28_HUMAN
θ value	5.27518 (rank : 198)	NC score	0.006473 (rank : 364)
Query Neighborhood Hits	209	Target Neighborhood Hits	271	Shared Neighborhood Hits	18
SwissProt Accessions	Q96AY4, O95928, O95929, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5	Gene names	TTC28, KIAA1043
Domain Architecture
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

ACOT1_HUMAN
θ value	6.88961 (rank : 199)	NC score	0.007743 (rank : 362)
Query Neighborhood Hits	209	Target Neighborhood Hits	16	Shared Neighborhood Hits	5
SwissProt Accessions	Q86TX2, Q3I5F9	Gene names	ACOT1, CTE1
Domain Architecture	No domain graphic available
Description	Acyl-coenzyme A thioesterase 1 (EC 3.1.2.2) (Acyl-CoA thioesterase 1) (Inducible cytosolic acyl-coenzyme A thioester hydrolase) (Long chain acyl-CoA thioester hydrolase) (Long chain acyl-CoA hydrolase) (CTE-I) (CTE-Ib).

K1802_HUMAN
θ value	6.88961 (rank : 200)	NC score	0.002943 (rank : 373)
Query Neighborhood Hits	209	Target Neighborhood Hits	1378	Shared Neighborhood Hits	24
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

LRIG1_HUMAN
θ value	6.88961 (rank : 201)	NC score	-0.002607 (rank : 377)
Query Neighborhood Hits	209	Target Neighborhood Hits	654	Shared Neighborhood Hits	6
SwissProt Accessions	Q96JA1, Q6IQ51, Q96CF9, Q9BYB8, Q9UFI4	Gene names	LRIG1, LIG1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

MYCB2_HUMAN
θ value	6.88961 (rank : 202)	NC score	0.010072 (rank : 359)
Query Neighborhood Hits	209	Target Neighborhood Hits	390	Shared Neighborhood Hits	17
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

TXLNG_MOUSE
θ value	6.88961 (rank : 203)	NC score	0.006112 (rank : 366)
Query Neighborhood Hits	209	Target Neighborhood Hits	552	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BHN1, Q8BP11	Gene names	Txlng
Domain Architecture	No domain graphic available
Description	Gamma-taxilin.

ACTN4_MOUSE
θ value	8.99809 (rank : 204)	NC score	0.002321 (rank : 375)
Query Neighborhood Hits	209	Target Neighborhood Hits	276	Shared Neighborhood Hits	10
SwissProt Accessions	P57780	Gene names	Actn4
Domain Architecture
Description	Alpha-actinin-4 (Non-muscle alpha-actinin 4) (F-actin cross-linking protein).

P85B_HUMAN
θ value	8.99809 (rank : 205)	NC score	0.056112 (rank : 293)
Query Neighborhood Hits	209	Target Neighborhood Hits	543	Shared Neighborhood Hits	35
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	8.99809 (rank : 206)	NC score	0.052791 (rank : 313)
Query Neighborhood Hits	209	Target Neighborhood Hits	519	Shared Neighborhood Hits	35
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PLEC1_HUMAN
θ value	8.99809 (rank : 207)	NC score	0.018418 (rank : 348)
Query Neighborhood Hits	209	Target Neighborhood Hits	1326	Shared Neighborhood Hits	44
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

SSFA2_HUMAN
θ value	8.99809 (rank : 208)	NC score	0.016598 (rank : 349)
Query Neighborhood Hits	209	Target Neighborhood Hits	40	Shared Neighborhood Hits	8
SwissProt Accessions	P28290, Q96E36	Gene names	SSFA2, CS1
Domain Architecture	No domain graphic available
Description	Sperm-specific antigen 2 (Cleavage signal-1 protein) (CS-1).

TARA_MOUSE
θ value	8.99809 (rank : 209)	NC score	0.044882 (rank : 330)
Query Neighborhood Hits	209	Target Neighborhood Hits	1133	Shared Neighborhood Hits	67
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

ABI1_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.058165 (rank : 285)
Query Neighborhood Hits	209	Target Neighborhood Hits	257	Shared Neighborhood Hits	27
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 211)	NC score	0.062184 (rank : 279)
Query Neighborhood Hits	209	Target Neighborhood Hits	246	Shared Neighborhood Hits	27
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.064312 (rank : 264)
Query Neighborhood Hits	209	Target Neighborhood Hits	350	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.063554 (rank : 270)
Query Neighborhood Hits	209	Target Neighborhood Hits	266	Shared Neighborhood Hits	23
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.057130 (rank : 289)
Query Neighborhood Hits	209	Target Neighborhood Hits	227	Shared Neighborhood Hits	26
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 215)	NC score	0.054688 (rank : 300)
Query Neighborhood Hits	209	Target Neighborhood Hits	227	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AHI1_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.055506 (rank : 297)
Query Neighborhood Hits	209	Target Neighborhood Hits	537	Shared Neighborhood Hits	30
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 217)	NC score	0.050935 (rank : 321)
Query Neighborhood Hits	209	Target Neighborhood Hits	496	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ARHG1_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.311448 (rank : 100)
Query Neighborhood Hits	209	Target Neighborhood Hits	176	Shared Neighborhood Hits	60
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 219)	NC score	0.286525 (rank : 114)
Query Neighborhood Hits	209	Target Neighborhood Hits	266	Shared Neighborhood Hits	59
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

BI2L1_HUMAN
θ value	θ > 10 (rank : 220)	NC score	0.060831 (rank : 282)
Query Neighborhood Hits	209	Target Neighborhood Hits	156	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CA106_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.073975 (rank : 232)
Query Neighborhood Hits	209	Target Neighborhood Hits	124	Shared Neighborhood Hits	11
SwissProt Accessions	Q3KP66, Q9NV65, Q9NVI0	Gene names	C1orf106
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106.

CA106_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.073199 (rank : 234)
Query Neighborhood Hits	209	Target Neighborhood Hits	89	Shared Neighborhood Hits	9
SwissProt Accessions	Q7TN12, Q7TN27, Q8BGK3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106 homolog.

CD2AP_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.093453 (rank : 167)
Query Neighborhood Hits	209	Target Neighborhood Hits	315	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 224)	NC score	0.093107 (rank : 169)
Query Neighborhood Hits	209	Target Neighborhood Hits	336	Shared Neighborhood Hits	29
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CD45_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.080179 (rank : 215)
Query Neighborhood Hits	209	Target Neighborhood Hits	243	Shared Neighborhood Hits	14
SwissProt Accessions	P08575, Q16614, Q9H0Y6	Gene names	PTPRC, CD45
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (CD45 antigen) (T200).

CD45_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.082260 (rank : 206)
Query Neighborhood Hits	209	Target Neighborhood Hits	178	Shared Neighborhood Hits	12
SwissProt Accessions	P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1	Gene names	Ptprc, Ly-5
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (Lymphocyte common antigen Ly-5) (CD45 antigen) (T200).

CRKL_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.055643 (rank : 296)
Query Neighborhood Hits	209	Target Neighborhood Hits	313	Shared Neighborhood Hits	23
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 228)	NC score	0.054266 (rank : 302)
Query Neighborhood Hits	209	Target Neighborhood Hits	307	Shared Neighborhood Hits	23
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.053441 (rank : 306)
Query Neighborhood Hits	209	Target Neighborhood Hits	308	Shared Neighborhood Hits	24
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 230)	NC score	0.055370 (rank : 298)
Query Neighborhood Hits	209	Target Neighborhood Hits	314	Shared Neighborhood Hits	25
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

DAPP1_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.050225 (rank : 324)
Query Neighborhood Hits	209	Target Neighborhood Hits	227	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 232)	NC score	0.051046 (rank : 319)
Query Neighborhood Hits	209	Target Neighborhood Hits	225	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DBNL_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.052823 (rank : 311)
Query Neighborhood Hits	209	Target Neighborhood Hits	244	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 234)	NC score	0.051520 (rank : 318)
Query Neighborhood Hits	209	Target Neighborhood Hits	306	Shared Neighborhood Hits	25
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

EEA1_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.069948 (rank : 242)
Query Neighborhood Hits	209	Target Neighborhood Hits	1796	Shared Neighborhood Hits	65
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

EEA1_MOUSE
θ value	θ > 10 (rank : 236)	NC score	0.073970 (rank : 233)
Query Neighborhood Hits	209	Target Neighborhood Hits	1637	Shared Neighborhood Hits	68
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

EP15R_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.050251 (rank : 323)
Query Neighborhood Hits	209	Target Neighborhood Hits	1083	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

EP15R_MOUSE
θ value	θ > 10 (rank : 238)	NC score	0.050491 (rank : 322)
Query Neighborhood Hits	209	Target Neighborhood Hits	1135	Shared Neighborhood Hits	42
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

FRMD1_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.469025 (rank : 61)
Query Neighborhood Hits	209	Target Neighborhood Hits	48	Shared Neighborhood Hits	42
SwissProt Accessions	Q8N878, Q5SZU7, Q9UFB0	Gene names	FRMD1
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 1.

FYCO1_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.070209 (rank : 240)
Query Neighborhood Hits	209	Target Neighborhood Hits	1149	Shared Neighborhood Hits	57
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

FYCO1_MOUSE
θ value	θ > 10 (rank : 241)	NC score	0.064763 (rank : 261)
Query Neighborhood Hits	209	Target Neighborhood Hits	1059	Shared Neighborhood Hits	56
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

FYV1_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.083850 (rank : 200)
Query Neighborhood Hits	209	Target Neighborhood Hits	217	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	θ > 10 (rank : 243)	NC score	0.081941 (rank : 207)
Query Neighborhood Hits	209	Target Neighborhood Hits	191	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

GRAP2_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.062384 (rank : 276)
Query Neighborhood Hits	209	Target Neighborhood Hits	304	Shared Neighborhood Hits	24
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 245)	NC score	0.062657 (rank : 275)
Query Neighborhood Hits	209	Target Neighborhood Hits	297	Shared Neighborhood Hits	23
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 246)	NC score	0.070444 (rank : 239)
Query Neighborhood Hits	209	Target Neighborhood Hits	307	Shared Neighborhood Hits	26
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 247)	NC score	0.069433 (rank : 243)
Query Neighborhood Hits	209	Target Neighborhood Hits	309	Shared Neighborhood Hits	27
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.064580 (rank : 262)
Query Neighborhood Hits	209	Target Neighborhood Hits	310	Shared Neighborhood Hits	24
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 249)	NC score	0.064560 (rank : 263)
Query Neighborhood Hits	209	Target Neighborhood Hits	312	Shared Neighborhood Hits	24
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

HCLS1_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.064076 (rank : 266)
Query Neighborhood Hits	209	Target Neighborhood Hits	358	Shared Neighborhood Hits	28
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 251)	NC score	0.065046 (rank : 259)
Query Neighborhood Hits	209	Target Neighborhood Hits	329	Shared Neighborhood Hits	29
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HGS_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.108883 (rank : 145)
Query Neighborhood Hits	209	Target Neighborhood Hits	517	Shared Neighborhood Hits	29
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	θ > 10 (rank : 253)	NC score	0.110245 (rank : 143)
Query Neighborhood Hits	209	Target Neighborhood Hits	589	Shared Neighborhood Hits	31
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

KRIT1_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.063708 (rank : 268)
Query Neighborhood Hits	209	Target Neighborhood Hits	258	Shared Neighborhood Hits	20
SwissProt Accessions	O00522, O43894, Q506L6, Q6U276, Q75N19, Q9H180, Q9H264, Q9HAX5	Gene names	KRIT1, CCM1
Domain Architecture
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein).

KRIT1_MOUSE
θ value	θ > 10 (rank : 255)	NC score	0.058708 (rank : 284)
Query Neighborhood Hits	209	Target Neighborhood Hits	258	Shared Neighborhood Hits	23
SwissProt Accessions	Q6S5J6, Q6VSV2, Q7TPR8, Q8C9Q6, Q9EPY2, Q9ERH0	Gene names	Krit1, Ccm1
Domain Architecture	No domain graphic available
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog).

LBC_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.314309 (rank : 99)
Query Neighborhood Hits	209	Target Neighborhood Hits	90	Shared Neighborhood Hits	54
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

MTMR3_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.073036 (rank : 235)
Query Neighborhood Hits	209	Target Neighborhood Hits	163	Shared Neighborhood Hits	17
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

NCF1_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.101661 (rank : 152)
Query Neighborhood Hits	209	Target Neighborhood Hits	198	Shared Neighborhood Hits	27
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 259)	NC score	0.094297 (rank : 162)
Query Neighborhood Hits	209	Target Neighborhood Hits	198	Shared Neighborhood Hits	26
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.084144 (rank : 197)
Query Neighborhood Hits	209	Target Neighborhood Hits	229	Shared Neighborhood Hits	28
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.080076 (rank : 217)
Query Neighborhood Hits	209	Target Neighborhood Hits	161	Shared Neighborhood Hits	20
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.078897 (rank : 221)
Query Neighborhood Hits	209	Target Neighborhood Hits	177	Shared Neighborhood Hits	22
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.077530 (rank : 222)
Query Neighborhood Hits	209	Target Neighborhood Hits	312	Shared Neighborhood Hits	30
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.074394 (rank : 231)
Query Neighborhood Hits	209	Target Neighborhood Hits	310	Shared Neighborhood Hits	31
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NEBL_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.053729 (rank : 304)
Query Neighborhood Hits	209	Target Neighborhood Hits	457	Shared Neighborhood Hits	33
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 266)	NC score	0.050940 (rank : 320)
Query Neighborhood Hits	209	Target Neighborhood Hits	114	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

OBSCN_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.057891 (rank : 286)
Query Neighborhood Hits	209	Target Neighborhood Hits	1931	Shared Neighborhood Hits	78
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

OSTF1_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.053131 (rank : 308)
Query Neighborhood Hits	209	Target Neighborhood Hits	466	Shared Neighborhood Hits	24
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.052840 (rank : 310)
Query Neighborhood Hits	209	Target Neighborhood Hits	467	Shared Neighborhood Hits	24
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PLCG1_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.053052 (rank : 309)
Query Neighborhood Hits	209	Target Neighborhood Hits	293	Shared Neighborhood Hits	29
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.053933 (rank : 303)
Query Neighborhood Hits	209	Target Neighborhood Hits	314	Shared Neighborhood Hits	29
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLEK2_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.071271 (rank : 238)
Query Neighborhood Hits	209	Target Neighborhood Hits	101	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.071652 (rank : 237)
Query Neighborhood Hits	209	Target Neighborhood Hits	96	Shared Neighborhood Hits	37
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PPIP1_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.061541 (rank : 281)
Query Neighborhood Hits	209	Target Neighborhood Hits	389	Shared Neighborhood Hits	33
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.063688 (rank : 269)
Query Neighborhood Hits	209	Target Neighborhood Hits	377	Shared Neighborhood Hits	35
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PTN11_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.089200 (rank : 177)
Query Neighborhood Hits	209	Target Neighborhood Hits	227	Shared Neighborhood Hits	17
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.089211 (rank : 176)
Query Neighborhood Hits	209	Target Neighborhood Hits	227	Shared Neighborhood Hits	17
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN12_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.087127 (rank : 185)
Query Neighborhood Hits	209	Target Neighborhood Hits	102	Shared Neighborhood Hits	10
SwissProt Accessions	Q05209, Q16130, Q59FD6, Q75MN8, Q86XU4	Gene names	PTPN12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase G1) (PTPG1).

PTN12_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.086845 (rank : 188)
Query Neighborhood Hits	209	Target Neighborhood Hits	123	Shared Neighborhood Hits	9
SwissProt Accessions	P35831	Gene names	Ptpn12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST).

PTN18_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.094431 (rank : 160)
Query Neighborhood Hits	209	Target Neighborhood Hits	73	Shared Neighborhood Hits	9
SwissProt Accessions	Q99952	Gene names	PTPN18, BDP1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase).

PTN18_MOUSE
θ value	θ > 10 (rank : 281)	NC score	0.091274 (rank : 173)
Query Neighborhood Hits	209	Target Neighborhood Hits	134	Shared Neighborhood Hits	8
SwissProt Accessions	Q61152, Q4JFH4, Q62404, Q922E3	Gene names	Ptpn18, Flp1, Ptpk1
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Fetal liver phosphatase 1) (FLP-1) (PTP-K1).

PTN1_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.094191 (rank : 164)
Query Neighborhood Hits	209	Target Neighborhood Hits	84	Shared Neighborhood Hits	8
SwissProt Accessions	P18031, Q5TGD8, Q9BQV9, Q9NQQ4	Gene names	PTPN1, PTP1B
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B).

PTN1_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.094491 (rank : 159)
Query Neighborhood Hits	209	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	P35821, Q60840, Q62131, Q64498, Q99JS1	Gene names	Ptpn1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) (Protein-protein-tyrosine phosphatase HA2) (PTP-HA2).

PTN22_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.088468 (rank : 180)
Query Neighborhood Hits	209	Target Neighborhood Hits	109	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

PTN22_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.087072 (rank : 187)
Query Neighborhood Hits	209	Target Neighborhood Hits	179	Shared Neighborhood Hits	13
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

PTN23_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.083000 (rank : 205)
Query Neighborhood Hits	209	Target Neighborhood Hits	646	Shared Neighborhood Hits	28
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

PTN23_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.080868 (rank : 212)
Query Neighborhood Hits	209	Target Neighborhood Hits	726	Shared Neighborhood Hits	30
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

PTN2_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.094214 (rank : 163)
Query Neighborhood Hits	209	Target Neighborhood Hits	92	Shared Neighborhood Hits	8
SwissProt Accessions	P17706, Q96HR2	Gene names	PTPN2, PTPT
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP).

PTN2_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.095200 (rank : 157)
Query Neighborhood Hits	209	Target Neighborhood Hits	107	Shared Neighborhood Hits	8
SwissProt Accessions	Q06180, Q3V259, Q922E7	Gene names	Ptpn2, Ptpt
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-2) (MPTP).

PTN5_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.081618 (rank : 208)
Query Neighborhood Hits	209	Target Neighborhood Hits	80	Shared Neighborhood Hits	8
SwissProt Accessions	P54829, Q8N2A1	Gene names	PTPN5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN5_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.081603 (rank : 209)
Query Neighborhood Hits	209	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	P54830, Q64694	Gene names	Ptpn5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN6_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.094727 (rank : 158)
Query Neighborhood Hits	209	Target Neighborhood Hits	234	Shared Neighborhood Hits	17
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.094403 (rank : 161)
Query Neighborhood Hits	209	Target Neighborhood Hits	225	Shared Neighborhood Hits	17
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

PTN7_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.087120 (rank : 186)
Query Neighborhood Hits	209	Target Neighborhood Hits	75	Shared Neighborhood Hits	8
SwissProt Accessions	P35236, Q9BV05	Gene names	PTPN7
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Protein-tyrosine phosphatase LC-PTP) (Hematopoietic protein-tyrosine phosphatase) (HEPTP).

PTN7_MOUSE
θ value	θ > 10 (rank : 295)	NC score	0.088091 (rank : 182)
Query Neighborhood Hits	209	Target Neighborhood Hits	71	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BUM3	Gene names	Ptpn7
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48).

PTN9_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.092290 (rank : 170)
Query Neighborhood Hits	209	Target Neighborhood Hits	79	Shared Neighborhood Hits	10
SwissProt Accessions	P43378	Gene names	PTPN9
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTN9_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.092107 (rank : 172)
Query Neighborhood Hits	209	Target Neighborhood Hits	78	Shared Neighborhood Hits	10
SwissProt Accessions	O35239, Q7TSK0	Gene names	Ptpn9
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTPR2_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.085007 (rank : 194)
Query Neighborhood Hits	209	Target Neighborhood Hits	103	Shared Neighborhood Hits	9
SwissProt Accessions	Q92932, Q8N4I5, Q92662	Gene names	PTPRN2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (Islet cell autoantigen-related protein) (ICAAR) (IAR) (Phogrin).

PTPR2_MOUSE
θ value	θ > 10 (rank : 299)	NC score	0.086058 (rank : 191)
Query Neighborhood Hits	209	Target Neighborhood Hits	120	Shared Neighborhood Hits	13
SwissProt Accessions	P80560, O09134, P70328	Gene names	Ptprn2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (PTP IA-2beta) (Protein tyrosine phosphatase-NP) (PTP-NP).

PTPRA_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.075753 (rank : 225)
Query Neighborhood Hits	209	Target Neighborhood Hits	101	Shared Neighborhood Hits	8
SwissProt Accessions	P18433, Q14513, Q7Z2I2, Q96TD9	Gene names	PTPRA, PTPA
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha).

PTPRA_MOUSE
θ value	θ > 10 (rank : 301)	NC score	0.075756 (rank : 224)
Query Neighborhood Hits	209	Target Neighborhood Hits	93	Shared Neighborhood Hits	8
SwissProt Accessions	P18052, Q61808	Gene names	Ptpra, Lrp, Ptpa
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (LCA- related phosphatase) (PTPTY-28).

PTPRB_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.079596 (rank : 218)
Query Neighborhood Hits	209	Target Neighborhood Hits	242	Shared Neighborhood Hits	9
SwissProt Accessions	P23467	Gene names	PTPRB, PTPB
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase beta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase beta) (R-PTP-beta).

PTPRD_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.054475 (rank : 301)
Query Neighborhood Hits	209	Target Neighborhood Hits	485	Shared Neighborhood Hits	13
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRD_MOUSE
θ value	θ > 10 (rank : 304)	NC score	0.052299 (rank : 314)
Query Neighborhood Hits	209	Target Neighborhood Hits	491	Shared Neighborhood Hits	13
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRE_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.076084 (rank : 223)
Query Neighborhood Hits	209	Target Neighborhood Hits	92	Shared Neighborhood Hits	8
SwissProt Accessions	P23469, Q96KQ6	Gene names	PTPRE
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRE_MOUSE
θ value	θ > 10 (rank : 306)	NC score	0.075683 (rank : 226)
Query Neighborhood Hits	209	Target Neighborhood Hits	86	Shared Neighborhood Hits	8
SwissProt Accessions	P49446, Q62134, Q62444, Q64496	Gene names	Ptpre, Ptpe
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRF_HUMAN
θ value	θ > 10 (rank : 307)	NC score	0.053157 (rank : 307)
Query Neighborhood Hits	209	Target Neighborhood Hits	489	Shared Neighborhood Hits	12
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

PTPRG_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.066762 (rank : 254)
Query Neighborhood Hits	209	Target Neighborhood Hits	231	Shared Neighborhood Hits	8
SwissProt Accessions	P23470, Q15623	Gene names	PTPRG
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRG_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.067843 (rank : 249)
Query Neighborhood Hits	209	Target Neighborhood Hits	260	Shared Neighborhood Hits	19
SwissProt Accessions	Q05909	Gene names	Ptprg
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRJ_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.081139 (rank : 211)
Query Neighborhood Hits	209	Target Neighborhood Hits	207	Shared Neighborhood Hits	8
SwissProt Accessions	Q12913, Q15255, Q8NHM2	Gene names	PTPRJ, DEP1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein- tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen).

PTPRJ_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.081581 (rank : 210)
Query Neighborhood Hits	209	Target Neighborhood Hits	188	Shared Neighborhood Hits	9
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

PTPRK_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.067708 (rank : 251)
Query Neighborhood Hits	209	Target Neighborhood Hits	228	Shared Neighborhood Hits	9
SwissProt Accessions	Q15262, Q14763	Gene names	PTPRK, PTPK
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRK_MOUSE
θ value	θ > 10 (rank : 313)	NC score	0.068292 (rank : 245)
Query Neighborhood Hits	209	Target Neighborhood Hits	223	Shared Neighborhood Hits	9
SwissProt Accessions	P35822	Gene names	Ptprk, Ptpk
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRM_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.063377 (rank : 271)
Query Neighborhood Hits	209	Target Neighborhood Hits	244	Shared Neighborhood Hits	9
SwissProt Accessions	P28827	Gene names	PTPRM, PTPRL1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTPRM_MOUSE
θ value	θ > 10 (rank : 315)	NC score	0.064084 (rank : 265)
Query Neighborhood Hits	209	Target Neighborhood Hits	238	Shared Neighborhood Hits	9
SwissProt Accessions	P28828	Gene names	Ptprm
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTPRN_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.085325 (rank : 193)
Query Neighborhood Hits	209	Target Neighborhood Hits	156	Shared Neighborhood Hits	13
SwissProt Accessions	Q16849, Q08319	Gene names	PTPRN, ICA3, ICA512
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3).

PTPRN_MOUSE
θ value	θ > 10 (rank : 317)	NC score	0.084888 (rank : 195)
Query Neighborhood Hits	209	Target Neighborhood Hits	240	Shared Neighborhood Hits	13
SwissProt Accessions	Q60673, Q62129	Gene names	Ptprn, Ptp35
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2).

PTPRO_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.085815 (rank : 192)
Query Neighborhood Hits	209	Target Neighborhood Hits	139	Shared Neighborhood Hits	9
SwissProt Accessions	Q16827, Q13101	Gene names	PTPRO, GLEPP1, PTPU2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase O precursor (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTPase U2) (PTP-U2).

PTPRR_HUMAN
θ value	θ > 10 (rank : 319)	NC score	0.083195 (rank : 204)
Query Neighborhood Hits	209	Target Neighborhood Hits	77	Shared Neighborhood Hits	8
SwissProt Accessions	Q15256, O00342, Q92682, Q9UE65	Gene names	PTPRR, ECPTP
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase).

PTPRR_MOUSE
θ value	θ > 10 (rank : 320)	NC score	0.083493 (rank : 202)
Query Neighborhood Hits	209	Target Neighborhood Hits	84	Shared Neighborhood Hits	9
SwissProt Accessions	Q62132, Q64491, Q64492, Q9QUH9	Gene names	Ptprr, Ptp13
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine-phosphatase SL) (Phosphotyrosine phosphatase 13).

PTPRS_HUMAN
θ value	θ > 10 (rank : 321)	NC score	0.055704 (rank : 295)
Query Neighborhood Hits	209	Target Neighborhood Hits	472	Shared Neighborhood Hits	13
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

PTPRT_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.065949 (rank : 256)
Query Neighborhood Hits	209	Target Neighborhood Hits	217	Shared Neighborhood Hits	9
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

PTPRT_MOUSE
θ value	θ > 10 (rank : 323)	NC score	0.066054 (rank : 255)
Query Neighborhood Hits	209	Target Neighborhood Hits	219	Shared Neighborhood Hits	9
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

PTPRU_HUMAN
θ value	θ > 10 (rank : 324)	NC score	0.064004 (rank : 267)
Query Neighborhood Hits	209	Target Neighborhood Hits	237	Shared Neighborhood Hits	10
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

PTPRV_MOUSE
θ value	θ > 10 (rank : 325)	NC score	0.080723 (rank : 213)
Query Neighborhood Hits	209	Target Neighborhood Hits	179	Shared Neighborhood Hits	9
SwissProt Accessions	P70289	Gene names	Ptprv, Esp
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase V precursor (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase).

PTPRZ_HUMAN
θ value	θ > 10 (rank : 326)	NC score	0.067884 (rank : 248)
Query Neighborhood Hits	209	Target Neighborhood Hits	255	Shared Neighborhood Hits	11
SwissProt Accessions	P23471	Gene names	PTPRZ1, PTPRZ, PTPZ
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase zeta precursor (EC 3.1.3.48) (R-PTP-zeta).

RBNS5_HUMAN
θ value	θ > 10 (rank : 327)	NC score	0.109531 (rank : 144)
Query Neighborhood Hits	209	Target Neighborhood Hits	242	Shared Neighborhood Hits	26
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	θ > 10 (rank : 328)	NC score	0.108761 (rank : 146)
Query Neighborhood Hits	209	Target Neighborhood Hits	266	Shared Neighborhood Hits	23
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

RHG04_HUMAN
θ value	θ > 10 (rank : 329)	NC score	0.052240 (rank : 315)
Query Neighborhood Hits	209	Target Neighborhood Hits	307	Shared Neighborhood Hits	31
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RIMB1_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.053729 (rank : 305)
Query Neighborhood Hits	209	Target Neighborhood Hits	1479	Shared Neighborhood Hits	61
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB1_MOUSE
θ value	θ > 10 (rank : 331)	NC score	0.056681 (rank : 292)
Query Neighborhood Hits	209	Target Neighborhood Hits	1376	Shared Neighborhood Hits	53
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RUFY1_HUMAN
θ value	θ > 10 (rank : 332)	NC score	0.083239 (rank : 203)
Query Neighborhood Hits	209	Target Neighborhood Hits	848	Shared Neighborhood Hits	44
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

RUFY1_MOUSE
θ value	θ > 10 (rank : 333)	NC score	0.074899 (rank : 229)
Query Neighborhood Hits	209	Target Neighborhood Hits	765	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY2_HUMAN
θ value	θ > 10 (rank : 334)	NC score	0.084232 (rank : 196)
Query Neighborhood Hits	209	Target Neighborhood Hits	1208	Shared Neighborhood Hits	51
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

RUFY2_MOUSE
θ value	θ > 10 (rank : 335)	NC score	0.089015 (rank : 178)
Query Neighborhood Hits	209	Target Neighborhood Hits	820	Shared Neighborhood Hits	46
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

SH3G1_HUMAN
θ value	θ > 10 (rank : 336)	NC score	0.064885 (rank : 260)
Query Neighborhood Hits	209	Target Neighborhood Hits	307	Shared Neighborhood Hits	27
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 337)	NC score	0.057831 (rank : 287)
Query Neighborhood Hits	209	Target Neighborhood Hits	291	Shared Neighborhood Hits	23
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.056885 (rank : 291)
Query Neighborhood Hits	209	Target Neighborhood Hits	324	Shared Neighborhood Hits	22
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 339)	NC score	0.056033 (rank : 294)
Query Neighborhood Hits	209	Target Neighborhood Hits	319	Shared Neighborhood Hits	22
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 340)	NC score	0.060201 (rank : 283)
Query Neighborhood Hits	209	Target Neighborhood Hits	222	Shared Neighborhood Hits	23
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 341)	NC score	0.061997 (rank : 280)
Query Neighborhood Hits	209	Target Neighborhood Hits	236	Shared Neighborhood Hits	22
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_HUMAN
θ value	θ > 10 (rank : 342)	NC score	0.100074 (rank : 154)
Query Neighborhood Hits	209	Target Neighborhood Hits	341	Shared Neighborhood Hits	29
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 343)	NC score	0.094025 (rank : 165)
Query Neighborhood Hits	209	Target Neighborhood Hits	332	Shared Neighborhood Hits	32
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SHAN2_MOUSE
θ value	θ > 10 (rank : 344)	NC score	0.055051 (rank : 299)
Query Neighborhood Hits	209	Target Neighborhood Hits	446	Shared Neighborhood Hits	39
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SRBS1_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.083748 (rank : 201)
Query Neighborhood Hits	209	Target Neighborhood Hits	396	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 346)	NC score	0.083966 (rank : 199)
Query Neighborhood Hits	209	Target Neighborhood Hits	409	Shared Neighborhood Hits	33
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 347)	NC score	0.063363 (rank : 272)
Query Neighborhood Hits	209	Target Neighborhood Hits	269	Shared Neighborhood Hits	23
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 348)	NC score	0.062316 (rank : 278)
Query Neighborhood Hits	209	Target Neighborhood Hits	292	Shared Neighborhood Hits	24
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRGP1_HUMAN
θ value	θ > 10 (rank : 349)	NC score	0.057121 (rank : 290)
Query Neighborhood Hits	209	Target Neighborhood Hits	390	Shared Neighborhood Hits	39
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

STAC3_HUMAN
θ value	θ > 10 (rank : 350)	NC score	0.067809 (rank : 250)
Query Neighborhood Hits	209	Target Neighborhood Hits	228	Shared Neighborhood Hits	23
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 351)	NC score	0.068169 (rank : 246)
Query Neighborhood Hits	209	Target Neighborhood Hits	232	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 352)	NC score	0.074527 (rank : 230)
Query Neighborhood Hits	209	Target Neighborhood Hits	276	Shared Neighborhood Hits	25
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 353)	NC score	0.071698 (rank : 236)
Query Neighborhood Hits	209	Target Neighborhood Hits	268	Shared Neighborhood Hits	25
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 354)	NC score	0.065758 (rank : 257)
Query Neighborhood Hits	209	Target Neighborhood Hits	271	Shared Neighborhood Hits	23
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 355)	NC score	0.065335 (rank : 258)
Query Neighborhood Hits	209	Target Neighborhood Hits	273	Shared Neighborhood Hits	25
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 356)	NC score	0.062705 (rank : 274)
Query Neighborhood Hits	209	Target Neighborhood Hits	288	Shared Neighborhood Hits	23
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 357)	NC score	0.063239 (rank : 273)
Query Neighborhood Hits	209	Target Neighborhood Hits	285	Shared Neighborhood Hits	24
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

SWP70_HUMAN
θ value	θ > 10 (rank : 358)	NC score	0.079242 (rank : 220)
Query Neighborhood Hits	209	Target Neighborhood Hits	973	Shared Neighborhood Hits	75
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
θ value	θ > 10 (rank : 359)	NC score	0.086608 (rank : 189)
Query Neighborhood Hits	209	Target Neighborhood Hits	1097	Shared Neighborhood Hits	78
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

TCGAP_HUMAN
θ value	θ > 10 (rank : 360)	NC score	0.052823 (rank : 312)
Query Neighborhood Hits	209	Target Neighborhood Hits	872	Shared Neighborhood Hits	49
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 361)	NC score	0.057661 (rank : 288)
Query Neighborhood Hits	209	Target Neighborhood Hits	409	Shared Neighborhood Hits	42
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

VINEX_HUMAN
θ value	θ > 10 (rank : 362)	NC score	0.080086 (rank : 216)
Query Neighborhood Hits	209	Target Neighborhood Hits	270	Shared Neighborhood Hits	33
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 363)	NC score	0.079250 (rank : 219)
Query Neighborhood Hits	209	Target Neighborhood Hits	286	Shared Neighborhood Hits	29
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

WDFY1_HUMAN
θ value	θ > 10 (rank : 364)	NC score	0.080248 (rank : 214)
Query Neighborhood Hits	209	Target Neighborhood Hits	305	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

WDFY2_HUMAN
θ value	θ > 10 (rank : 365)	NC score	0.067640 (rank : 252)
Query Neighborhood Hits	209	Target Neighborhood Hits	332	Shared Neighborhood Hits	16
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

WDFY2_MOUSE
θ value	θ > 10 (rank : 366)	NC score	0.068144 (rank : 247)
Query Neighborhood Hits	209	Target Neighborhood Hits	337	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

WDFY3_HUMAN
θ value	θ > 10 (rank : 367)	NC score	0.075563 (rank : 227)
Query Neighborhood Hits	209	Target Neighborhood Hits	348	Shared Neighborhood Hits	17
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY3_MOUSE
θ value	θ > 10 (rank : 368)	NC score	0.075274 (rank : 228)
Query Neighborhood Hits	209	Target Neighborhood Hits	332	Shared Neighborhood Hits	16
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

ZFY16_HUMAN
θ value	θ > 10 (rank : 369)	NC score	0.139686 (rank : 136)
Query Neighborhood Hits	209	Target Neighborhood Hits	125	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY16_MOUSE
θ value	θ > 10 (rank : 370)	NC score	0.143583 (rank : 133)
Query Neighborhood Hits	209	Target Neighborhood Hits	108	Shared Neighborhood Hits	17
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY19_HUMAN
θ value	θ > 10 (rank : 371)	NC score	0.091248 (rank : 174)
Query Neighborhood Hits	209	Target Neighborhood Hits	206	Shared Neighborhood Hits	18
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ZFY19_MOUSE
θ value	θ > 10 (rank : 372)	NC score	0.084137 (rank : 198)
Query Neighborhood Hits	209	Target Neighborhood Hits	143	Shared Neighborhood Hits	17
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

ZFY21_HUMAN
θ value	θ > 10 (rank : 373)	NC score	0.138388 (rank : 137)
Query Neighborhood Hits	209	Target Neighborhood Hits	72	Shared Neighborhood Hits	16
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_MOUSE
θ value	θ > 10 (rank : 374)	NC score	0.141178 (rank : 135)
Query Neighborhood Hits	209	Target Neighborhood Hits	72	Shared Neighborhood Hits	16
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY28_HUMAN
θ value	θ > 10 (rank : 375)	NC score	0.153911 (rank : 129)
Query Neighborhood Hits	209	Target Neighborhood Hits	152	Shared Neighborhood Hits	19
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV1_HUMAN
θ value	θ > 10 (rank : 376)	NC score	0.093952 (rank : 166)
Query Neighborhood Hits	209	Target Neighborhood Hits	166	Shared Neighborhood Hits	16
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
θ value	θ > 10 (rank : 377)	NC score	0.092131 (rank : 171)
Query Neighborhood Hits	209	Target Neighborhood Hits	153	Shared Neighborhood Hits	16
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

ZFYV9_HUMAN
θ value	θ > 10 (rank : 378)	NC score	0.151102 (rank : 131)
Query Neighborhood Hits	209	Target Neighborhood Hits	134	Shared Neighborhood Hits	18
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

Hits sorted by NC score

FARP2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	209	Target Neighborhood Hits	209	Shared Neighborhood Hits	209
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_HUMAN
NC score	0.989644 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	209	Target Neighborhood Hits	240	Shared Neighborhood Hits	164
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP1_HUMAN
NC score	0.977847 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	209	Target Neighborhood Hits	241	Shared Neighborhood Hits	153
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

E41L3_HUMAN
NC score	0.770864 (rank : 4)	θ value	2.3998e-69 (rank : 5)
Query Neighborhood Hits	209	Target Neighborhood Hits	113	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

E41L5_HUMAN
NC score	0.768659 (rank : 5)	θ value	1.0458e-56 (rank : 13)
Query Neighborhood Hits	209	Target Neighborhood Hits	76	Shared Neighborhood Hits	47
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

E41LB_MOUSE
NC score	0.768215 (rank : 6)	θ value	3.1488e-53 (rank : 14)
Query Neighborhood Hits	209	Target Neighborhood Hits	59	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

41_HUMAN
NC score	0.766288 (rank : 7)	θ value	1.31681e-67 (rank : 7)
Query Neighborhood Hits	209	Target Neighborhood Hits	157	Shared Neighborhood Hits	48
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

FRMD5_MOUSE
NC score	0.765744 (rank : 8)	θ value	6.35935e-46 (rank : 18)
Query Neighborhood Hits	209	Target Neighborhood Hits	55	Shared Neighborhood Hits	48
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

E41L1_MOUSE
NC score	0.765233 (rank : 9)	θ value	2.10232e-65 (rank : 10)
Query Neighborhood Hits	209	Target Neighborhood Hits	106	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41LB_HUMAN
NC score	0.763501 (rank : 10)	θ value	7.75577e-52 (rank : 15)
Query Neighborhood Hits	209	Target Neighborhood Hits	79	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

FRMD5_HUMAN
NC score	0.763408 (rank : 11)	θ value	1.08474e-45 (rank : 19)
Query Neighborhood Hits	209	Target Neighborhood Hits	55	Shared Neighborhood Hits	48
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

41_MOUSE
NC score	0.763174 (rank : 12)	θ value	3.71096e-62 (rank : 12)
Query Neighborhood Hits	209	Target Neighborhood Hits	184	Shared Neighborhood Hits	51
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

E41L1_HUMAN
NC score	0.761267 (rank : 13)	θ value	9.43692e-66 (rank : 9)
Query Neighborhood Hits	209	Target Neighborhood Hits	180	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L3_MOUSE
NC score	0.759544 (rank : 14)	θ value	3.13423e-69 (rank : 6)
Query Neighborhood Hits	209	Target Neighborhood Hits	250	Shared Neighborhood Hits	49
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

E41LA_HUMAN
NC score	0.756131 (rank : 15)	θ value	5.95217e-44 (rank : 21)
Query Neighborhood Hits	209	Target Neighborhood Hits	87	Shared Neighborhood Hits	48
SwissProt Accessions	Q9HCS5	Gene names	EPB41L4A, EPB41L4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41L2_HUMAN
NC score	0.755250 (rank : 16)	θ value	5.53243e-66 (rank : 8)
Query Neighborhood Hits	209	Target Neighborhood Hits	287	Shared Neighborhood Hits	49
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41LA_MOUSE
NC score	0.754809 (rank : 17)	θ value	3.61106e-41 (rank : 23)
Query Neighborhood Hits	209	Target Neighborhood Hits	85	Shared Neighborhood Hits	49
SwissProt Accessions	P52963	Gene names	Epb41l4a, Epb4.1l4, Epb4.1l4a, Epb41l4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41L2_MOUSE
NC score	0.740137 (rank : 18)	θ value	6.76295e-64 (rank : 11)
Query Neighborhood Hits	209	Target Neighborhood Hits	459	Shared Neighborhood Hits	56
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

MYLIP_MOUSE
NC score	0.695217 (rank : 19)	θ value	5.23862e-24 (rank : 48)
Query Neighborhood Hits	209	Target Neighborhood Hits	139	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

MYLIP_HUMAN
NC score	0.683992 (rank : 20)	θ value	1.05554e-24 (rank : 45)
Query Neighborhood Hits	209	Target Neighborhood Hits	162	Shared Neighborhood Hits	44
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

FRM4B_HUMAN
NC score	0.638033 (rank : 21)	θ value	1.24977e-17 (rank : 54)
Query Neighborhood Hits	209	Target Neighborhood Hits	117	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y2L6, Q8TAI3	Gene names	FRMD4B, KIAA1013
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1).

FRM4B_MOUSE
NC score	0.636075 (rank : 22)	θ value	2.13179e-17 (rank : 55)
Query Neighborhood Hits	209	Target Neighborhood Hits	109	Shared Neighborhood Hits	49
SwissProt Accessions	Q920B0, Q3V1S1, Q9ESP9	Gene names	Frmd4b
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1) (Golgi- associated band 4.1-like protein) (GOBLIN).

FRM4A_MOUSE
NC score	0.634023 (rank : 23)	θ value	3.51386e-20 (rank : 51)
Query Neighborhood Hits	209	Target Neighborhood Hits	108	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BIE6, Q6PDJ4, Q8CHA6	Gene names	Frmd4a, Frmd4, Kiaa1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

FRM4A_HUMAN
NC score	0.632588 (rank : 24)	θ value	1.02238e-19 (rank : 53)
Query Neighborhood Hits	209	Target Neighborhood Hits	110	Shared Neighborhood Hits	48
SwissProt Accessions	Q9P2Q2	Gene names	FRMD4A, FRMD4, KIAA1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

MERL_MOUSE
NC score	0.629989 (rank : 25)	θ value	1.57365e-28 (rank : 40)
Query Neighborhood Hits	209	Target Neighborhood Hits	524	Shared Neighborhood Hits	62
SwissProt Accessions	P46662, Q8BR03	Gene names	Nf2, Nf-2
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin).

MERL_HUMAN
NC score	0.629336 (rank : 26)	θ value	1.2049e-28 (rank : 39)
Query Neighborhood Hits	209	Target Neighborhood Hits	532	Shared Neighborhood Hits	61
SwissProt Accessions	P35240, O95683, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4	Gene names	NF2, SCH
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Schwannomerlin).

EZRI_HUMAN
NC score	0.600077 (rank : 27)	θ value	3.17079e-29 (rank : 37)
Query Neighborhood Hits	209	Target Neighborhood Hits	663	Shared Neighborhood Hits	64
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

EZRI_MOUSE
NC score	0.597323 (rank : 28)	θ value	1.4233e-29 (rank : 35)
Query Neighborhood Hits	209	Target Neighborhood Hits	693	Shared Neighborhood Hits	66
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

RADI_HUMAN
NC score	0.588438 (rank : 29)	θ value	3.61944e-33 (rank : 27)
Query Neighborhood Hits	209	Target Neighborhood Hits	741	Shared Neighborhood Hits	65
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

FGD4_HUMAN
NC score	0.586028 (rank : 30)	θ value	2.41655e-45 (rank : 20)
Query Neighborhood Hits	209	Target Neighborhood Hits	219	Shared Neighborhood Hits	98
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
NC score	0.585772 (rank : 31)	θ value	3.72821e-46 (rank : 17)
Query Neighborhood Hits	209	Target Neighborhood Hits	227	Shared Neighborhood Hits	96
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

RADI_MOUSE
NC score	0.584868 (rank : 32)	θ value	3.61944e-33 (rank : 28)
Query Neighborhood Hits	209	Target Neighborhood Hits	773	Shared Neighborhood Hits	65
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

FGD3_MOUSE
NC score	0.575865 (rank : 33)	θ value	5.06226e-27 (rank : 41)
Query Neighborhood Hits	209	Target Neighborhood Hits	257	Shared Neighborhood Hits	92
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD1_HUMAN
NC score	0.574343 (rank : 34)	θ value	2.19075e-38 (rank : 26)
Query Neighborhood Hits	209	Target Neighborhood Hits	367	Shared Neighborhood Hits	96
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
NC score	0.571431 (rank : 35)	θ value	9.83387e-39 (rank : 25)
Query Neighborhood Hits	209	Target Neighborhood Hits	387	Shared Neighborhood Hits	93
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_HUMAN
NC score	0.569556 (rank : 36)	θ value	1.85889e-29 (rank : 36)
Query Neighborhood Hits	209	Target Neighborhood Hits	151	Shared Neighborhood Hits	87
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
NC score	0.569012 (rank : 37)	θ value	1.16434e-31 (rank : 30)
Query Neighborhood Hits	209	Target Neighborhood Hits	163	Shared Neighborhood Hits	88
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
NC score	0.566456 (rank : 38)	θ value	1.6813e-30 (rank : 33)
Query Neighborhood Hits	209	Target Neighborhood Hits	249	Shared Neighborhood Hits	76
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD6_MOUSE
NC score	0.558066 (rank : 39)	θ value	1.79215e-40 (rank : 24)
Query Neighborhood Hits	209	Target Neighborhood Hits	282	Shared Neighborhood Hits	103
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

MOES_HUMAN
NC score	0.553469 (rank : 40)	θ value	1.52067e-31 (rank : 32)
Query Neighborhood Hits	209	Target Neighborhood Hits	892	Shared Neighborhood Hits	70
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

FGD6_HUMAN
NC score	0.553023 (rank : 41)	θ value	9.50281e-42 (rank : 22)
Query Neighborhood Hits	209	Target Neighborhood Hits	237	Shared Neighborhood Hits	99
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

MOES_MOUSE
NC score	0.547007 (rank : 42)	θ value	1.16434e-31 (rank : 31)
Query Neighborhood Hits	209	Target Neighborhood Hits	923	Shared Neighborhood Hits	70
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

PTN4_HUMAN
NC score	0.543994 (rank : 43)	θ value	4.51533e-76 (rank : 4)
Query Neighborhood Hits	209	Target Neighborhood Hits	303	Shared Neighborhood Hits	50
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

PREX1_HUMAN
NC score	0.533522 (rank : 44)	θ value	7.0802e-21 (rank : 49)
Query Neighborhood Hits	209	Target Neighborhood Hits	177	Shared Neighborhood Hits	80
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PTN3_HUMAN
NC score	0.519509 (rank : 45)	θ value	3.98324e-48 (rank : 16)
Query Neighborhood Hits	209	Target Neighborhood Hits	258	Shared Neighborhood Hits	49
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

ARHG4_MOUSE
NC score	0.511200 (rank : 46)	θ value	5.23862e-24 (rank : 47)
Query Neighborhood Hits	209	Target Neighborhood Hits	185	Shared Neighborhood Hits	70
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PKHG1_HUMAN
NC score	0.504905 (rank : 47)	θ value	1.29331e-14 (rank : 60)
Query Neighborhood Hits	209	Target Neighborhood Hits	174	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

FRMD6_MOUSE
NC score	0.504555 (rank : 48)	θ value	0.000121331 (rank : 115)
Query Neighborhood Hits	209	Target Neighborhood Hits	63	Shared Neighborhood Hits	42
SwissProt Accessions	Q8C0V9, Q8BW34	Gene names	Frmd6
Domain Architecture
Description	FERM domain-containing protein 6.

FGD5_HUMAN
NC score	0.501109 (rank : 49)	θ value	8.91499e-32 (rank : 29)
Query Neighborhood Hits	209	Target Neighborhood Hits	235	Shared Neighborhood Hits	72
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

ARHG4_HUMAN
NC score	0.499779 (rank : 50)	θ value	3.62785e-25 (rank : 43)
Query Neighborhood Hits	209	Target Neighborhood Hits	242	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

FRMD6_HUMAN
NC score	0.496219 (rank : 51)	θ value	0.00102713 (rank : 121)
Query Neighborhood Hits	209	Target Neighborhood Hits	60	Shared Neighborhood Hits	42
SwissProt Accessions	Q96NE9, Q5HYF2, Q8N2X1, Q8WUH7	Gene names	FRMD6, C14orf31
Domain Architecture
Description	FERM domain-containing protein 6 (Willin).

PTN21_MOUSE
NC score	0.495403 (rank : 52)	θ value	8.3442e-30 (rank : 34)
Query Neighborhood Hits	209	Target Neighborhood Hits	155	Shared Neighborhood Hits	46
SwissProt Accessions	Q62136	Gene names	Ptpn21
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-RL10).

PTN21_HUMAN
NC score	0.493797 (rank : 53)	θ value	5.40856e-29 (rank : 38)
Query Neighborhood Hits	209	Target Neighborhood Hits	143	Shared Neighborhood Hits	46
SwissProt Accessions	Q16825	Gene names	PTPN21, PTPD1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1).

FGD5_MOUSE
NC score	0.491085 (rank : 54)	θ value	1.92365e-26 (rank : 42)
Query Neighborhood Hits	209	Target Neighborhood Hits	170	Shared Neighborhood Hits	78
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

ARHG9_HUMAN
NC score	0.482878 (rank : 55)	θ value	6.20254e-17 (rank : 56)
Query Neighborhood Hits	209	Target Neighborhood Hits	235	Shared Neighborhood Hits	71
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.481913 (rank : 56)	θ value	6.20254e-17 (rank : 57)
Query Neighborhood Hits	209	Target Neighborhood Hits	234	Shared Neighborhood Hits	71
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ECT2_MOUSE
NC score	0.479712 (rank : 57)	θ value	3.29651e-10 (rank : 79)
Query Neighborhood Hits	209	Target Neighborhood Hits	98	Shared Neighborhood Hits	72
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

PTN14_MOUSE
NC score	0.478873 (rank : 58)	θ value	8.08199e-25 (rank : 44)
Query Neighborhood Hits	209	Target Neighborhood Hits	142	Shared Neighborhood Hits	46
SwissProt Accessions	Q62130	Gene names	Ptpn14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP36).

PTN14_HUMAN
NC score	0.473060 (rank : 59)	θ value	2.35151e-24 (rank : 46)
Query Neighborhood Hits	209	Target Neighborhood Hits	163	Shared Neighborhood Hits	47
SwissProt Accessions	Q15678	Gene names	PTPN14, PEZ
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez).

ECT2_HUMAN
NC score	0.470893 (rank : 60)	θ value	1.25267e-09 (rank : 81)
Query Neighborhood Hits	209	Target Neighborhood Hits	98	Shared Neighborhood Hits	73
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

FRMD1_HUMAN
NC score	0.469025 (rank : 61)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	209	Target Neighborhood Hits	48	Shared Neighborhood Hits	42
SwissProt Accessions	Q8N878, Q5SZU7, Q9UFB0	Gene names	FRMD1
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 1.

ARHGG_HUMAN
NC score	0.445598 (rank : 62)	θ value	3.29651e-10 (rank : 78)
Query Neighborhood Hits	209	Target Neighborhood Hits	129	Shared Neighborhood Hits	68
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
NC score	0.439345 (rank : 63)	θ value	6.64225e-11 (rank : 70)
Query Neighborhood Hits	209	Target Neighborhood Hits	152	Shared Neighborhood Hits	66
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

NGEF_HUMAN
NC score	0.431108 (rank : 64)	θ value	2.52405e-10 (rank : 76)
Query Neighborhood Hits	209	Target Neighborhood Hits	166	Shared Neighborhood Hits	69
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHG5_HUMAN
NC score	0.430869 (rank : 65)	θ value	6.21693e-09 (rank : 85)
Query Neighborhood Hits	209	Target Neighborhood Hits	172	Shared Neighborhood Hits	69
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

NGEF_MOUSE
NC score	0.424657 (rank : 66)	θ value	1.47974e-10 (rank : 73)
Query Neighborhood Hits	209	Target Neighborhood Hits	228	Shared Neighborhood Hits	70
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

TIAM1_MOUSE
NC score	0.424331 (rank : 67)	θ value	3.08544e-08 (rank : 89)
Query Neighborhood Hits	209	Target Neighborhood Hits	205	Shared Neighborhood Hits	79
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_HUMAN
NC score	0.423822 (rank : 68)	θ value	2.52405e-10 (rank : 77)
Query Neighborhood Hits	209	Target Neighborhood Hits	225	Shared Neighborhood Hits	78
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

MCF2_HUMAN
NC score	0.408765 (rank : 69)	θ value	5.81887e-07 (rank : 97)
Query Neighborhood Hits	209	Target Neighborhood Hits	166	Shared Neighborhood Hits	71
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ARHG7_HUMAN
NC score	0.392429 (rank : 70)	θ value	3.07829e-16 (rank : 58)
Query Neighborhood Hits	209	Target Neighborhood Hits	347	Shared Neighborhood Hits	80
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG8_HUMAN
NC score	0.387137 (rank : 71)	θ value	1.29631e-06 (rank : 100)
Query Neighborhood Hits	209	Target Neighborhood Hits	85	Shared Neighborhood Hits	67
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHGA_HUMAN
NC score	0.386676 (rank : 72)	θ value	0.00175202 (rank : 125)
Query Neighborhood Hits	209	Target Neighborhood Hits	187	Shared Neighborhood Hits	70
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

GNRP_MOUSE
NC score	0.386464 (rank : 73)	θ value	5.08577e-11 (rank : 69)
Query Neighborhood Hits	209	Target Neighborhood Hits	191	Shared Neighborhood Hits	90
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ARHG2_MOUSE
NC score	0.385166 (rank : 74)	θ value	8.67504e-11 (rank : 71)
Query Neighborhood Hits	209	Target Neighborhood Hits	120	Shared Neighborhood Hits	62
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHGF_HUMAN
NC score	0.382561 (rank : 75)	θ value	0.000158464 (rank : 116)
Query Neighborhood Hits	209	Target Neighborhood Hits	214	Shared Neighborhood Hits	71
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGA_MOUSE
NC score	0.381949 (rank : 76)	θ value	0.00665767 (rank : 129)
Query Neighborhood Hits	209	Target Neighborhood Hits	125	Shared Neighborhood Hits	64
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

PTN13_MOUSE
NC score	0.381305 (rank : 77)	θ value	1.5773e-20 (rank : 50)
Query Neighborhood Hits	209	Target Neighborhood Hits	426	Shared Neighborhood Hits	52
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

MCF2L_MOUSE
NC score	0.376570 (rank : 78)	θ value	1.87187e-05 (rank : 107)
Query Neighborhood Hits	209	Target Neighborhood Hits	255	Shared Neighborhood Hits	70
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

ARHG7_MOUSE
NC score	0.375481 (rank : 79)	θ value	4.59992e-12 (rank : 65)
Query Neighborhood Hits	209	Target Neighborhood Hits	396	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

PTN13_HUMAN
NC score	0.374707 (rank : 80)	θ value	3.51386e-20 (rank : 52)
Query Neighborhood Hits	209	Target Neighborhood Hits	471	Shared Neighborhood Hits	56
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

ARHG3_HUMAN
NC score	0.366047 (rank : 81)	θ value	0.00035302 (rank : 119)
Query Neighborhood Hits	209	Target Neighborhood Hits	82	Shared Neighborhood Hits	64
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.365744 (rank : 82)	θ value	0.000602161 (rank : 120)
Query Neighborhood Hits	209	Target Neighborhood Hits	85	Shared Neighborhood Hits	64
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHGB_HUMAN
NC score	0.363509 (rank : 83)	θ value	3.64472e-09 (rank : 83)
Query Neighborhood Hits	209	Target Neighborhood Hits	375	Shared Neighborhood Hits	73
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHG8_MOUSE
NC score	0.361490 (rank : 84)	θ value	1.43324e-05 (rank : 106)
Query Neighborhood Hits	209	Target Neighborhood Hits	79	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

HAPIP_HUMAN
NC score	0.359903 (rank : 85)	θ value	5.81887e-07 (rank : 96)
Query Neighborhood Hits	209	Target Neighborhood Hits	350	Shared Neighborhood Hits	76
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ARHG6_HUMAN
NC score	0.351602 (rank : 86)	θ value	1.33837e-11 (rank : 68)
Query Neighborhood Hits	209	Target Neighborhood Hits	376	Shared Neighborhood Hits	67
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

GNRP_HUMAN
NC score	0.345352 (rank : 87)	θ value	1.9326e-10 (rank : 74)
Query Neighborhood Hits	209	Target Neighborhood Hits	239	Shared Neighborhood Hits	90
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

DNMBP_MOUSE
NC score	0.344498 (rank : 88)	θ value	1.133e-10 (rank : 72)
Query Neighborhood Hits	209	Target Neighborhood Hits	435	Shared Neighborhood Hits	76
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

PKHG4_HUMAN
NC score	0.344046 (rank : 89)	θ value	0.00134147 (rank : 124)
Query Neighborhood Hits	209	Target Neighborhood Hits	200	Shared Neighborhood Hits	60
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

ARHG6_MOUSE
NC score	0.340634 (rank : 90)	θ value	4.16044e-13 (rank : 63)
Query Neighborhood Hits	209	Target Neighborhood Hits	394	Shared Neighborhood Hits	68
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG2_HUMAN
NC score	0.332994 (rank : 91)	θ value	9.59137e-10 (rank : 80)
Query Neighborhood Hits	209	Target Neighborhood Hits	142	Shared Neighborhood Hits	59
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHGC_HUMAN
NC score	0.332660 (rank : 92)	θ value	4.1701e-05 (rank : 111)
Query Neighborhood Hits	209	Target Neighborhood Hits	351	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
NC score	0.329590 (rank : 93)	θ value	7.1131e-05 (rank : 114)
Query Neighborhood Hits	209	Target Neighborhood Hits	344	Shared Neighborhood Hits	71
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

DNMBP_HUMAN
NC score	0.327288 (rank : 94)	θ value	1.63604e-09 (rank : 82)
Query Neighborhood Hits	209	Target Neighborhood Hits	413	Shared Neighborhood Hits	72
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

PKHF2_HUMAN
NC score	0.323219 (rank : 95)	θ value	8.11959e-09 (rank : 86)
Query Neighborhood Hits	209	Target Neighborhood Hits	75	Shared Neighborhood Hits	28
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
NC score	0.322777 (rank : 96)	θ value	8.11959e-09 (rank : 87)
Query Neighborhood Hits	209	Target Neighborhood Hits	77	Shared Neighborhood Hits	31
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHF1_MOUSE
NC score	0.315443 (rank : 97)	θ value	8.97725e-08 (rank : 94)
Query Neighborhood Hits	209	Target Neighborhood Hits	80	Shared Neighborhood Hits	27
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF1_HUMAN
NC score	0.315221 (rank : 98)	θ value	5.26297e-08 (rank : 91)
Query Neighborhood Hits	209	Target Neighborhood Hits	76	Shared Neighborhood Hits	24
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

LBC_HUMAN
NC score	0.314309 (rank : 99)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	209	Target Neighborhood Hits	90	Shared Neighborhood Hits	54
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHG1_HUMAN
NC score	0.311448 (rank : 100)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	209	Target Neighborhood Hits	176	Shared Neighborhood Hits	60
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ITSN2_HUMAN
NC score	0.304678 (rank : 101)	θ value	4.59992e-12 (rank : 66)
Query Neighborhood Hits	209	Target Neighborhood Hits	1173	Shared Neighborhood Hits	90
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

VAV_MOUSE
NC score	0.304060 (rank : 102)	θ value	1.09739e-05 (rank : 105)
Query Neighborhood Hits	209	Target Neighborhood Hits	430	Shared Neighborhood Hits	71
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

RGNEF_MOUSE
NC score	0.301117 (rank : 103)	θ value	3.19293e-05 (rank : 109)
Query Neighborhood Hits	209	Target Neighborhood Hits	641	Shared Neighborhood Hits	75
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

VAV2_MOUSE
NC score	0.300127 (rank : 104)	θ value	2.44474e-05 (rank : 108)
Query Neighborhood Hits	209	Target Neighborhood Hits	456	Shared Neighborhood Hits	74
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_MOUSE
NC score	0.298214 (rank : 105)	θ value	4.0297e-08 (rank : 90)
Query Neighborhood Hits	209	Target Neighborhood Hits	404	Shared Neighborhood Hits	70
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ITSN2_MOUSE
NC score	0.297919 (rank : 106)	θ value	4.59992e-12 (rank : 67)
Query Neighborhood Hits	209	Target Neighborhood Hits	1371	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

VAV_HUMAN
NC score	0.297793 (rank : 107)	θ value	6.43352e-06 (rank : 103)
Query Neighborhood Hits	209	Target Neighborhood Hits	452	Shared Neighborhood Hits	70
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ABR_HUMAN
NC score	0.297544 (rank : 108)	θ value	2.52405e-10 (rank : 75)
Query Neighborhood Hits	209	Target Neighborhood Hits	166	Shared Neighborhood Hits	72
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

VAV2_HUMAN
NC score	0.297155 (rank : 109)	θ value	3.19293e-05 (rank : 110)
Query Neighborhood Hits	209	Target Neighborhood Hits	453	Shared Neighborhood Hits	75
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

BCR_HUMAN
NC score	0.296469 (rank : 110)	θ value	6.87365e-08 (rank : 92)
Query Neighborhood Hits	209	Target Neighborhood Hits	204	Shared Neighborhood Hits	71
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

VAV3_HUMAN
NC score	0.293993 (rank : 111)	θ value	9.92553e-07 (rank : 99)
Query Neighborhood Hits	209	Target Neighborhood Hits	398	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ITSN1_MOUSE
NC score	0.291455 (rank : 112)	θ value	6.41864e-14 (rank : 61)
Query Neighborhood Hits	209	Target Neighborhood Hits	1669	Shared Neighborhood Hits	101
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN1_HUMAN
NC score	0.289343 (rank : 113)	θ value	4.44505e-15 (rank : 59)
Query Neighborhood Hits	209	Target Neighborhood Hits	1757	Shared Neighborhood Hits	102
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ARHG1_MOUSE
NC score	0.286525 (rank : 114)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	209	Target Neighborhood Hits	266	Shared Neighborhood Hits	59
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

TLN1_HUMAN
NC score	0.285589 (rank : 115)	θ value	0.0148317 (rank : 132)
Query Neighborhood Hits	209	Target Neighborhood Hits	218	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

TLN1_MOUSE
NC score	0.281457 (rank : 116)	θ value	0.0431538 (rank : 137)
Query Neighborhood Hits	209	Target Neighborhood Hits	213	Shared Neighborhood Hits	47
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

TLN2_MOUSE
NC score	0.274653 (rank : 117)	θ value	1.06291 (rank : 165)
Query Neighborhood Hits	209	Target Neighborhood Hits	149	Shared Neighborhood Hits	46
SwissProt Accessions	Q71LX4, Q8BWK0	Gene names	Tln2
Domain Architecture	No domain graphic available
Description	Talin-2.

TLN2_HUMAN
NC score	0.271969 (rank : 118)	θ value	0.813845 (rank : 160)
Query Neighborhood Hits	209	Target Neighborhood Hits	157	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y4G6	Gene names	TLN2, KIAA0320
Domain Architecture
Description	Talin-2.

SOS1_HUMAN
NC score	0.243744 (rank : 119)	θ value	1.53129e-07 (rank : 95)
Query Neighborhood Hits	209	Target Neighborhood Hits	274	Shared Neighborhood Hits	49
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS2_HUMAN
NC score	0.232096 (rank : 120)	θ value	2.21117e-06 (rank : 101)
Query Neighborhood Hits	209	Target Neighborhood Hits	193	Shared Neighborhood Hits	49
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

PKHA6_MOUSE
NC score	0.231827 (rank : 121)	θ value	1.06045e-08 (rank : 88)
Query Neighborhood Hits	209	Target Neighborhood Hits	591	Shared Neighborhood Hits	74
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

SOS1_MOUSE
NC score	0.230223 (rank : 122)	θ value	3.77169e-06 (rank : 102)
Query Neighborhood Hits	209	Target Neighborhood Hits	281	Shared Neighborhood Hits	48
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

PKHA6_HUMAN
NC score	0.221997 (rank : 123)	θ value	4.76016e-09 (rank : 84)
Query Neighborhood Hits	209	Target Neighborhood Hits	556	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA5_HUMAN
NC score	0.178290 (rank : 124)	θ value	8.97725e-08 (rank : 93)
Query Neighborhood Hits	209	Target Neighborhood Hits	455	Shared Neighborhood Hits	63
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA4_MOUSE
NC score	0.175194 (rank : 125)	θ value	0.000270298 (rank : 117)
Query Neighborhood Hits	209	Target Neighborhood Hits	202	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA2_MOUSE
NC score	0.169918 (rank : 126)	θ value	7.59969e-07 (rank : 98)
Query Neighborhood Hits	209	Target Neighborhood Hits	116	Shared Neighborhood Hits	48
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA4_HUMAN
NC score	0.162790 (rank : 127)	θ value	0.00390308 (rank : 128)
Query Neighborhood Hits	209	Target Neighborhood Hits	283	Shared Neighborhood Hits	54
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA2_HUMAN
NC score	0.157581 (rank : 128)	θ value	4.1701e-05 (rank : 112)
Query Neighborhood Hits	209	Target Neighborhood Hits	119	Shared Neighborhood Hits	45
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

ZFY28_HUMAN
NC score	0.153911 (rank : 129)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	209	Target Neighborhood Hits	152	Shared Neighborhood Hits	19
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

DUET_HUMAN
NC score	0.152120 (rank : 130)	θ value	8.38298e-14 (rank : 62)
Query Neighborhood Hits	209	Target Neighborhood Hits	1220	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

ZFYV9_HUMAN
NC score	0.151102 (rank : 131)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	209	Target Neighborhood Hits	134	Shared Neighborhood Hits	18
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

TRIO_HUMAN
NC score	0.147592 (rank : 132)	θ value	4.16044e-13 (rank : 64)
Query Neighborhood Hits	209	Target Neighborhood Hits	1580	Shared Neighborhood Hits	96
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

ZFY16_MOUSE
NC score	0.143583 (rank : 133)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	209	Target Neighborhood Hits	108	Shared Neighborhood Hits	17
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

PLEK_HUMAN
NC score	0.143285 (rank : 134)	θ value	1.09739e-05 (rank : 104)
Query Neighborhood Hits	209	Target Neighborhood Hits	110	Shared Neighborhood Hits	45
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

ZFY21_MOUSE
NC score	0.141178 (rank : 135)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	209	Target Neighborhood Hits	72	Shared Neighborhood Hits	16
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY16_HUMAN
NC score	0.139686 (rank : 136)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	209	Target Neighborhood Hits	125	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY21_HUMAN
NC score	0.138388 (rank : 137)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	209	Target Neighborhood Hits	72	Shared Neighborhood Hits	16
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

PLEK_MOUSE
NC score	0.135878 (rank : 138)	θ value	5.44631e-05 (rank : 113)
Query Neighborhood Hits	209	Target Neighborhood Hits	109	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

PKHA1_MOUSE
NC score	0.125039 (rank : 139)	θ value	0.00134147 (rank : 123)
Query Neighborhood Hits	209	Target Neighborhood Hits	120	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_HUMAN
NC score	0.124735 (rank : 140)	θ value	0.00102713 (rank : 122)
Query Neighborhood Hits	209	Target Neighborhood Hits	127	Shared Neighborhood Hits	43
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

CNKR1_HUMAN
NC score	0.120322 (rank : 141)	θ value	0.0330416 (rank : 133)
Query Neighborhood Hits	209	Target Neighborhood Hits	154	Shared Neighborhood Hits	39
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

ALS2_HUMAN
NC score	0.112810 (rank : 142)	θ value	0.00035302 (rank : 118)
Query Neighborhood Hits	209	Target Neighborhood Hits	121	Shared Neighborhood Hits	30
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

HGS_MOUSE
NC score	0.110245 (rank : 143)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	209	Target Neighborhood Hits	589	Shared Neighborhood Hits	31
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

RBNS5_HUMAN
NC score	0.109531 (rank : 144)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	209	Target Neighborhood Hits	242	Shared Neighborhood Hits	26
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

HGS_HUMAN
NC score	0.108883 (rank : 145)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	209	Target Neighborhood Hits	517	Shared Neighborhood Hits	29
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

RBNS5_MOUSE
NC score	0.108761 (rank : 146)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	209	Target Neighborhood Hits	266	Shared Neighborhood Hits	23
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

CNKR2_MOUSE
NC score	0.107958 (rank : 147)	θ value	0.279714 (rank : 150)
Query Neighborhood Hits	209	Target Neighborhood Hits	197	Shared Neighborhood Hits	43
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.107696 (rank : 148)	θ value	0.279714 (rank : 149)
Query Neighborhood Hits	209	Target Neighborhood Hits	197	Shared Neighborhood Hits	42
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

ALS2_MOUSE
NC score	0.107001 (rank : 149)	θ value	0.0148317 (rank : 131)
Query Neighborhood Hits	209	Target Neighborhood Hits	111	Shared Neighborhood Hits	28
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

CYH3_MOUSE
NC score	0.104492 (rank : 150)	θ value	0.00665767 (rank : 130)
Query Neighborhood Hits	209	Target Neighborhood Hits	148	Shared Neighborhood Hits	56
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

3BP2_MOUSE
NC score	0.103099 (rank : 151)	θ value	0.279714 (rank : 148)
Query Neighborhood Hits	209	Target Neighborhood Hits	142	Shared Neighborhood Hits	41
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

NCF1_HUMAN
NC score	0.101661 (rank : 152)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	209	Target Neighborhood Hits	198	Shared Neighborhood Hits	27
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

3BP2_HUMAN
NC score	0.100647 (rank : 153)	θ value	0.21417 (rank : 143)
Query Neighborhood Hits	209	Target Neighborhood Hits	296	Shared Neighborhood Hits	40
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

SH3K1_HUMAN
NC score	0.100074 (rank : 154)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	209	Target Neighborhood Hits	341	Shared Neighborhood Hits	29
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

C43BP_MOUSE
NC score	0.099995 (rank : 155)	θ value	0.00175202 (rank : 127)
Query Neighborhood Hits	209	Target Neighborhood Hits	91	Shared Neighborhood Hits	32
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

C43BP_HUMAN
NC score	0.098478 (rank : 156)	θ value	0.00175202 (rank : 126)
Query Neighborhood Hits	209	Target Neighborhood Hits	87	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

PTN2_MOUSE
NC score	0.095200 (rank : 157)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	209	Target Neighborhood Hits	107	Shared Neighborhood Hits	8
SwissProt Accessions	Q06180, Q3V259, Q922E7	Gene names	Ptpn2, Ptpt
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-2) (MPTP).

PTN6_HUMAN
NC score	0.094727 (rank : 158)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	209	Target Neighborhood Hits	234	Shared Neighborhood Hits	17
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN1_MOUSE
NC score	0.094491 (rank : 159)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	209	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	P35821, Q60840, Q62131, Q64498, Q99JS1	Gene names	Ptpn1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) (Protein-protein-tyrosine phosphatase HA2) (PTP-HA2).

PTN18_HUMAN
NC score	0.094431 (rank : 160)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	209	Target Neighborhood Hits	73	Shared Neighborhood Hits	9
SwissProt Accessions	Q99952	Gene names	PTPN18, BDP1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase).

PTN6_MOUSE
NC score	0.094403 (rank : 161)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	209	Target Neighborhood Hits	225	Shared Neighborhood Hits	17
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

NCF1_MOUSE
NC score	0.094297 (rank : 162)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	209	Target Neighborhood Hits	198	Shared Neighborhood Hits	26
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

PTN2_HUMAN
NC score	0.094214 (rank : 163)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	209	Target Neighborhood Hits	92	Shared Neighborhood Hits	8
SwissProt Accessions	P17706, Q96HR2	Gene names	PTPN2, PTPT
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP).

PTN1_HUMAN
NC score	0.094191 (rank : 164)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	209	Target Neighborhood Hits	84	Shared Neighborhood Hits	8
SwissProt Accessions	P18031, Q5TGD8, Q9BQV9, Q9NQQ4	Gene names	PTPN1, PTP1B
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B).

SH3K1_MOUSE
NC score	0.094025 (rank : 165)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	209	Target Neighborhood Hits	332	Shared Neighborhood Hits	32
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

ZFYV1_HUMAN
NC score	0.093952 (rank : 166)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	209	Target Neighborhood Hits	166	Shared Neighborhood Hits	16
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

CD2AP_HUMAN
NC score	0.093453 (rank : 167)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	209	Target Neighborhood Hits	315	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CYH3_HUMAN
NC score	0.093335 (rank : 168)	θ value	0.0431538 (rank : 135)
Query Neighborhood Hits	209	Target Neighborhood Hits	137	Shared Neighborhood Hits	49
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

CD2AP_MOUSE
NC score	0.093107 (rank : 169)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	209	Target Neighborhood Hits	336	Shared Neighborhood Hits	29
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

PTN9_HUMAN
NC score	0.092290 (rank : 170)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	209	Target Neighborhood Hits	79	Shared Neighborhood Hits	10
SwissProt Accessions	P43378	Gene names	PTPN9
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

ZFYV1_MOUSE
NC score	0.092131 (rank : 171)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	209	Target Neighborhood Hits	153	Shared Neighborhood Hits	16
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

PTN9_MOUSE
NC score	0.092107 (rank : 172)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	209	Target Neighborhood Hits	78	Shared Neighborhood Hits	10
SwissProt Accessions	O35239, Q7TSK0	Gene names	Ptpn9
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTN18_MOUSE
NC score	0.091274 (rank : 173)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	209	Target Neighborhood Hits	134	Shared Neighborhood Hits	8
SwissProt Accessions	Q61152, Q4JFH4, Q62404, Q922E3	Gene names	Ptpn18, Flp1, Ptpk1
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Fetal liver phosphatase 1) (FLP-1) (PTP-K1).

ZFY19_HUMAN
NC score	0.091248 (rank : 174)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	209	Target Neighborhood Hits	206	Shared Neighborhood Hits	18
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

CYH4_MOUSE
NC score	0.091029 (rank : 175)	θ value	0.47712 (rank : 154)
Query Neighborhood Hits	209	Target Neighborhood Hits	134	Shared Neighborhood Hits	53
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

PTN11_MOUSE
NC score	0.089211 (rank : 176)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	209	Target Neighborhood Hits	227	Shared Neighborhood Hits	17
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.089200 (rank : 177)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	209	Target Neighborhood Hits	227	Shared Neighborhood Hits	17
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

RUFY2_MOUSE
NC score	0.089015 (rank : 178)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	209	Target Neighborhood Hits	820	Shared Neighborhood Hits	46
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

CYH1_HUMAN
NC score	0.088851 (rank : 179)	θ value	0.62314 (rank : 156)
Query Neighborhood Hits	209	Target Neighborhood Hits	184	Shared Neighborhood Hits	58
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

PTN22_HUMAN
NC score	0.088468 (rank : 180)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	209	Target Neighborhood Hits	109	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

CYH4_HUMAN
NC score	0.088438 (rank : 181)	θ value	0.365318 (rank : 152)
Query Neighborhood Hits	209	Target Neighborhood Hits	135	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

PTN7_MOUSE
NC score	0.088091 (rank : 182)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	209	Target Neighborhood Hits	71	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BUM3	Gene names	Ptpn7
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48).

CYH2_MOUSE
NC score	0.087416 (rank : 183)	θ value	0.21417 (rank : 146)
Query Neighborhood Hits	209	Target Neighborhood Hits	171	Shared Neighborhood Hits	55
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH2_HUMAN
NC score	0.087413 (rank : 184)	θ value	0.21417 (rank : 145)
Query Neighborhood Hits	209	Target Neighborhood Hits	175	Shared Neighborhood Hits	55
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

PTN12_HUMAN
NC score	0.087127 (rank : 185)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	209	Target Neighborhood Hits	102	Shared Neighborhood Hits	10
SwissProt Accessions	Q05209, Q16130, Q59FD6, Q75MN8, Q86XU4	Gene names	PTPN12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase G1) (PTPG1).

PTN7_HUMAN
NC score	0.087120 (rank : 186)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	209	Target Neighborhood Hits	75	Shared Neighborhood Hits	8
SwissProt Accessions	P35236, Q9BV05	Gene names	PTPN7
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Protein-tyrosine phosphatase LC-PTP) (Hematopoietic protein-tyrosine phosphatase) (HEPTP).

PTN22_MOUSE
NC score	0.087072 (rank : 187)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	209	Target Neighborhood Hits	179	Shared Neighborhood Hits	13
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

PTN12_MOUSE
NC score	0.086845 (rank : 188)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	209	Target Neighborhood Hits	123	Shared Neighborhood Hits	9
SwissProt Accessions	P35831	Gene names	Ptpn12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST).

SWP70_MOUSE
NC score	0.086608 (rank : 189)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	209	Target Neighborhood Hits	1097	Shared Neighborhood Hits	78
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

CYH1_MOUSE
NC score	0.086502 (rank : 190)	θ value	0.62314 (rank : 157)
Query Neighborhood Hits	209	Target Neighborhood Hits	176	Shared Neighborhood Hits	55
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

PTPR2_MOUSE
NC score	0.086058 (rank : 191)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	209	Target Neighborhood Hits	120	Shared Neighborhood Hits	13
SwissProt Accessions	P80560, O09134, P70328	Gene names	Ptprn2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (PTP IA-2beta) (Protein tyrosine phosphatase-NP) (PTP-NP).

PTPRO_HUMAN
NC score	0.085815 (rank : 192)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	209	Target Neighborhood Hits	139	Shared Neighborhood Hits	9
SwissProt Accessions	Q16827, Q13101	Gene names	PTPRO, GLEPP1, PTPU2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase O precursor (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTPase U2) (PTP-U2).

PTPRN_HUMAN
NC score	0.085325 (rank : 193)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	209	Target Neighborhood Hits	156	Shared Neighborhood Hits	13
SwissProt Accessions	Q16849, Q08319	Gene names	PTPRN, ICA3, ICA512
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3).

PTPR2_HUMAN
NC score	0.085007 (rank : 194)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	209	Target Neighborhood Hits	103	Shared Neighborhood Hits	9
SwissProt Accessions	Q92932, Q8N4I5, Q92662	Gene names	PTPRN2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (Islet cell autoantigen-related protein) (ICAAR) (IAR) (Phogrin).

PTPRN_MOUSE
NC score	0.084888 (rank : 195)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	209	Target Neighborhood Hits	240	Shared Neighborhood Hits	13
SwissProt Accessions	Q60673, Q62129	Gene names	Ptprn, Ptp35
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2).

RUFY2_HUMAN
NC score	0.084232 (rank : 196)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	209	Target Neighborhood Hits	1208	Shared Neighborhood Hits	51
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

NCF2_HUMAN
NC score	0.084144 (rank : 197)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	209	Target Neighborhood Hits	229	Shared Neighborhood Hits	28
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

ZFY19_MOUSE
NC score	0.084137 (rank : 198)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	209	Target Neighborhood Hits	143	Shared Neighborhood Hits	17
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

SRBS1_MOUSE
NC score	0.083966 (rank : 199)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	209	Target Neighborhood Hits	409	Shared Neighborhood Hits	33
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

FYV1_HUMAN
NC score	0.083850 (rank : 200)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	209	Target Neighborhood Hits	217	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

SRBS1_HUMAN
NC score	0.083748 (rank : 201)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	209	Target Neighborhood Hits	396	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

PTPRR_MOUSE
NC score	0.083493 (rank : 202)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	209	Target Neighborhood Hits	84	Shared Neighborhood Hits	9
SwissProt Accessions	Q62132, Q64491, Q64492, Q9QUH9	Gene names	Ptprr, Ptp13
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine-phosphatase SL) (Phosphotyrosine phosphatase 13).

RUFY1_HUMAN
NC score	0.083239 (rank : 203)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	209	Target Neighborhood Hits	848	Shared Neighborhood Hits	44
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

PTPRR_HUMAN
NC score	0.083195 (rank : 204)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	209	Target Neighborhood Hits	77	Shared Neighborhood Hits	8
SwissProt Accessions	Q15256, O00342, Q92682, Q9UE65	Gene names	PTPRR, ECPTP
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase).

PTN23_HUMAN
NC score	0.083000 (rank : 205)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	209	Target Neighborhood Hits	646	Shared Neighborhood Hits	28
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

CD45_MOUSE
NC score	0.082260 (rank : 206)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	209	Target Neighborhood Hits	178	Shared Neighborhood Hits	12
SwissProt Accessions	P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1	Gene names	Ptprc, Ly-5
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (Lymphocyte common antigen Ly-5) (CD45 antigen) (T200).

FYV1_MOUSE
NC score	0.081941 (rank : 207)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	209	Target Neighborhood Hits	191	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

PTN5_HUMAN
NC score	0.081618 (rank : 208)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	209	Target Neighborhood Hits	80	Shared Neighborhood Hits	8
SwissProt Accessions	P54829, Q8N2A1	Gene names	PTPN5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN5_MOUSE
NC score	0.081603 (rank : 209)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	209	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	P54830, Q64694	Gene names	Ptpn5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTPRJ_MOUSE
NC score	0.081581 (rank : 210)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	209	Target Neighborhood Hits	188	Shared Neighborhood Hits	9
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

PTPRJ_HUMAN
NC score	0.081139 (rank : 211)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	209	Target Neighborhood Hits	207	Shared Neighborhood Hits	8
SwissProt Accessions	Q12913, Q15255, Q8NHM2	Gene names	PTPRJ, DEP1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein- tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen).

PTN23_MOUSE
NC score	0.080868 (rank : 212)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	209	Target Neighborhood Hits	726	Shared Neighborhood Hits	30
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

PTPRV_MOUSE
NC score	0.080723 (rank : 213)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	209	Target Neighborhood Hits	179	Shared Neighborhood Hits	9
SwissProt Accessions	P70289	Gene names	Ptprv, Esp
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase V precursor (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase).

WDFY1_HUMAN
NC score	0.080248 (rank : 214)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	209	Target Neighborhood Hits	305	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

CD45_HUMAN
NC score	0.080179 (rank : 215)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	209	Target Neighborhood Hits	243	Shared Neighborhood Hits	14
SwissProt Accessions	P08575, Q16614, Q9H0Y6	Gene names	PTPRC, CD45
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (CD45 antigen) (T200).

VINEX_HUMAN
NC score	0.080086 (rank : 216)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	209	Target Neighborhood Hits	270	Shared Neighborhood Hits	33
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

NCF4_HUMAN
NC score	0.080076 (rank : 217)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	209	Target Neighborhood Hits	161	Shared Neighborhood Hits	20
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

PTPRB_HUMAN
NC score	0.079596 (rank : 218)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	209	Target Neighborhood Hits	242	Shared Neighborhood Hits	9
SwissProt Accessions	P23467	Gene names	PTPRB, PTPB
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase beta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase beta) (R-PTP-beta).

VINEX_MOUSE
NC score	0.079250 (rank : 219)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	209	Target Neighborhood Hits	286	Shared Neighborhood Hits	29
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

SWP70_HUMAN
NC score	0.079242 (rank : 220)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	209	Target Neighborhood Hits	973	Shared Neighborhood Hits	75
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

NCF4_MOUSE
NC score	0.078897 (rank : 221)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	209	Target Neighborhood Hits	177	Shared Neighborhood Hits	22
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
NC score	0.077530 (rank : 222)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	209	Target Neighborhood Hits	312	Shared Neighborhood Hits	30
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

PTPRE_HUMAN
NC score	0.076084 (rank : 223)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	209	Target Neighborhood Hits	92	Shared Neighborhood Hits	8
SwissProt Accessions	P23469, Q96KQ6	Gene names	PTPRE
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRA_MOUSE
NC score	0.075756 (rank : 224)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	209	Target Neighborhood Hits	93	Shared Neighborhood Hits	8
SwissProt Accessions	P18052, Q61808	Gene names	Ptpra, Lrp, Ptpa
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (LCA- related phosphatase) (PTPTY-28).

PTPRA_HUMAN
NC score	0.075753 (rank : 225)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	209	Target Neighborhood Hits	101	Shared Neighborhood Hits	8
SwissProt Accessions	P18433, Q14513, Q7Z2I2, Q96TD9	Gene names	PTPRA, PTPA
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha).

PTPRE_MOUSE
NC score	0.075683 (rank : 226)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	209	Target Neighborhood Hits	86	Shared Neighborhood Hits	8
SwissProt Accessions	P49446, Q62134, Q62444, Q64496	Gene names	Ptpre, Ptpe
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

WDFY3_HUMAN
NC score	0.075563 (rank : 227)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	209	Target Neighborhood Hits	348	Shared Neighborhood Hits	17
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY3_MOUSE
NC score	0.075274 (rank : 228)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	209	Target Neighborhood Hits	332	Shared Neighborhood Hits	16
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

RUFY1_MOUSE
NC score	0.074899 (rank : 229)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	209	Target Neighborhood Hits	765	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

STAC_HUMAN
NC score	0.074527 (rank : 230)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	209	Target Neighborhood Hits	276	Shared Neighborhood Hits	25
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

NCK2_HUMAN
NC score	0.074394 (rank : 231)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	209	Target Neighborhood Hits	310	Shared Neighborhood Hits	31
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

CA106_HUMAN
NC score	0.073975 (rank : 232)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	209	Target Neighborhood Hits	124	Shared Neighborhood Hits	11
SwissProt Accessions	Q3KP66, Q9NV65, Q9NVI0	Gene names	C1orf106
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106.

EEA1_MOUSE
NC score	0.073970 (rank : 233)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	209	Target Neighborhood Hits	1637	Shared Neighborhood Hits	68
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

CA106_MOUSE
NC score	0.073199 (rank : 234)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	209	Target Neighborhood Hits	89	Shared Neighborhood Hits	9
SwissProt Accessions	Q7TN12, Q7TN27, Q8BGK3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106 homolog.

MTMR3_HUMAN
NC score	0.073036 (rank : 235)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	209	Target Neighborhood Hits	163	Shared Neighborhood Hits	17
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

STAC_MOUSE
NC score	0.071698 (rank : 236)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	209	Target Neighborhood Hits	268	Shared Neighborhood Hits	25
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

PLEK2_MOUSE
NC score	0.071652 (rank : 237)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	209	Target Neighborhood Hits	96	Shared Neighborhood Hits	37
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_HUMAN
NC score	0.071271 (rank : 238)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	209	Target Neighborhood Hits	101	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

GRAP_HUMAN
NC score	0.070444 (rank : 239)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	209	Target Neighborhood Hits	307	Shared Neighborhood Hits	26
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

FYCO1_HUMAN
NC score	0.070209 (rank : 240)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	209	Target Neighborhood Hits	1149	Shared Neighborhood Hits	57
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

RHG25_HUMAN
NC score	0.069964 (rank : 241)	θ value	0.47712 (rank : 155)
Query Neighborhood Hits	209	Target Neighborhood Hits	550	Shared Neighborhood Hits	61
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

EEA1_HUMAN
NC score	0.069948 (rank : 242)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	209	Target Neighborhood Hits	1796	Shared Neighborhood Hits	65
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

GRAP_MOUSE
NC score	0.069433 (rank : 243)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	209	Target Neighborhood Hits	309	Shared Neighborhood Hits	27
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

RHG25_MOUSE
NC score	0.068906 (rank : 244)	θ value	0.365318 (rank : 153)
Query Neighborhood Hits	209	Target Neighborhood Hits	492	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

PTPRK_MOUSE
NC score	0.068292 (rank : 245)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	209	Target Neighborhood Hits	223	Shared Neighborhood Hits	9
SwissProt Accessions	P35822	Gene names	Ptprk, Ptpk
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

STAC3_MOUSE
NC score	0.068169 (rank : 246)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	209	Target Neighborhood Hits	232	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

WDFY2_MOUSE
NC score	0.068144 (rank : 247)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	209	Target Neighborhood Hits	337	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

PTPRZ_HUMAN
NC score	0.067884 (rank : 248)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	209	Target Neighborhood Hits	255	Shared Neighborhood Hits	11
SwissProt Accessions	P23471	Gene names	PTPRZ1, PTPRZ, PTPZ
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase zeta precursor (EC 3.1.3.48) (R-PTP-zeta).

PTPRG_MOUSE
NC score	0.067843 (rank : 249)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	209	Target Neighborhood Hits	260	Shared Neighborhood Hits	19
SwissProt Accessions	Q05909	Gene names	Ptprg
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

STAC3_HUMAN
NC score	0.067809 (rank : 250)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	209	Target Neighborhood Hits	228	Shared Neighborhood Hits	23
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

PTPRK_HUMAN
NC score	0.067708 (rank : 251)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	209	Target Neighborhood Hits	228	Shared Neighborhood Hits	9
SwissProt Accessions	Q15262, Q14763	Gene names	PTPRK, PTPK
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

WDFY2_HUMAN
NC score	0.067640 (rank : 252)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	209	Target Neighborhood Hits	332	Shared Neighborhood Hits	16
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

OSBL9_HUMAN
NC score	0.066960 (rank : 253)	θ value	0.21417 (rank : 147)
Query Neighborhood Hits	209	Target Neighborhood Hits	138	Shared Neighborhood Hits	39
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

PTPRG_HUMAN
NC score	0.066762 (rank : 254)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	209	Target Neighborhood Hits	231	Shared Neighborhood Hits	8
SwissProt Accessions	P23470, Q15623	Gene names	PTPRG
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRT_MOUSE
NC score	0.066054 (rank : 255)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	209	Target Neighborhood Hits	219	Shared Neighborhood Hits	9
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

PTPRT_HUMAN
NC score	0.065949 (rank : 256)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	209	Target Neighborhood Hits	217	Shared Neighborhood Hits	9
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

STAM1_HUMAN
NC score	0.065758 (rank : 257)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	209	Target Neighborhood Hits	271	Shared Neighborhood Hits	23
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
NC score	0.065335 (rank : 258)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	209	Target Neighborhood Hits	273	Shared Neighborhood Hits	25
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

HCLS1_MOUSE
NC score	0.065046 (rank : 259)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	209	Target Neighborhood Hits	329	Shared Neighborhood Hits	29
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

SH3G1_HUMAN
NC score	0.064885 (rank : 260)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	209	Target Neighborhood Hits	307	Shared Neighborhood Hits	27
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

FYCO1_MOUSE
NC score	0.064763 (rank : 261)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	209	Target Neighborhood Hits	1059	Shared Neighborhood Hits	56
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

GRB2_HUMAN
NC score	0.064580 (rank : 262)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	209	Target Neighborhood Hits	310	Shared Neighborhood Hits	24
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.064560 (rank : 263)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	209	Target Neighborhood Hits	312	Shared Neighborhood Hits	24
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

ABI2_HUMAN
NC score	0.064312 (rank : 264)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	209	Target Neighborhood Hits	350	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

PTPRM_MOUSE
NC score	0.064084 (rank : 265)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	209	Target Neighborhood Hits	238	Shared Neighborhood Hits	9
SwissProt Accessions	P28828	Gene names	Ptprm
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

HCLS1_HUMAN
NC score	0.064076 (rank : 266)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	209	Target Neighborhood Hits	358	Shared Neighborhood Hits	28
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

PTPRU_HUMAN
NC score	0.064004 (rank : 267)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	209	Target Neighborhood Hits	237	Shared Neighborhood Hits	10
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

KRIT1_HUMAN
NC score	0.063708 (rank : 268)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	209	Target Neighborhood Hits	258	Shared Neighborhood Hits	20
SwissProt Accessions	O00522, O43894, Q506L6, Q6U276, Q75N19, Q9H180, Q9H264, Q9HAX5	Gene names	KRIT1, CCM1
Domain Architecture
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein).

PPIP1_MOUSE
NC score	0.063688 (rank : 269)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	209	Target Neighborhood Hits	377	Shared Neighborhood Hits	35
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

ABI2_MOUSE
NC score	0.063554 (rank : 270)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	209	Target Neighborhood Hits	266	Shared Neighborhood Hits	23
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

PTPRM_HUMAN
NC score	0.063377 (rank : 271)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	209	Target Neighborhood Hits	244	Shared Neighborhood Hits	9
SwissProt Accessions	P28827	Gene names	PTPRM, PTPRL1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

SRC8_HUMAN
NC score	0.063363 (rank : 272)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	209	Target Neighborhood Hits	269	Shared Neighborhood Hits	23
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

STAM2_MOUSE
NC score	0.063239 (rank : 273)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	209	Target Neighborhood Hits	285	Shared Neighborhood Hits	24
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STAM2_HUMAN
NC score	0.062705 (rank : 274)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	209	Target Neighborhood Hits	288	Shared Neighborhood Hits	23
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

GRAP2_MOUSE
NC score	0.062657 (rank : 275)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	209	Target Neighborhood Hits	297	Shared Neighborhood Hits	23
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP2_HUMAN
NC score	0.062384 (rank : 276)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	209	Target Neighborhood Hits	304	Shared Neighborhood Hits	24
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

K1914_HUMAN
NC score	0.062332 (rank : 277)	θ value	0.163984 (rank : 142)
Query Neighborhood Hits	209	Target Neighborhood Hits	255	Shared Neighborhood Hits	26
SwissProt Accessions	Q8N4X5, Q8TB54, Q96PX4, Q96SY5	Gene names	KIAA1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

SRC8_MOUSE
NC score	0.062316 (rank : 278)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	209	Target Neighborhood Hits	292	Shared Neighborhood Hits	24
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

ABI1_MOUSE
NC score	0.062184 (rank : 279)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	209	Target Neighborhood Hits	246	Shared Neighborhood Hits	27
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

SH3G3_MOUSE
NC score	0.061997 (rank : 280)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	209	Target Neighborhood Hits	236	Shared Neighborhood Hits	22
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

PPIP1_HUMAN
NC score	0.061541 (rank : 281)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	209	Target Neighborhood Hits	389	Shared Neighborhood Hits	33
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

BI2L1_HUMAN
NC score	0.060831 (rank : 282)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	209	Target Neighborhood Hits	156	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

SH3G3_HUMAN
NC score	0.060201 (rank : 283)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	209	Target Neighborhood Hits	222	Shared Neighborhood Hits	23
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

KRIT1_MOUSE
NC score	0.058708 (rank : 284)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	209	Target Neighborhood Hits	258	Shared Neighborhood Hits	23
SwissProt Accessions	Q6S5J6, Q6VSV2, Q7TPR8, Q8C9Q6, Q9EPY2, Q9ERH0	Gene names	Krit1, Ccm1
Domain Architecture	No domain graphic available
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog).

ABI1_HUMAN
NC score	0.058165 (rank : 285)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	209	Target Neighborhood Hits	257	Shared Neighborhood Hits	27
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

OBSCN_HUMAN
NC score	0.057891 (rank : 286)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	209	Target Neighborhood Hits	1931	Shared Neighborhood Hits	78
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

SH3G1_MOUSE
NC score	0.057831 (rank : 287)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	209	Target Neighborhood Hits	291	Shared Neighborhood Hits	23
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

TCGAP_MOUSE
NC score	0.057661 (rank : 288)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	209	Target Neighborhood Hits	409	Shared Neighborhood Hits	42
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ABI3_HUMAN
NC score	0.057130 (rank : 289)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	209	Target Neighborhood Hits	227	Shared Neighborhood Hits	26
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

SRGP1_HUMAN
NC score	0.057121 (rank : 290)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	209	Target Neighborhood Hits	390	Shared Neighborhood Hits	39
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SH3G2_HUMAN
NC score	0.056885 (rank : 291)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	209	Target Neighborhood Hits	324	Shared Neighborhood Hits	22
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

RIMB1_MOUSE
NC score	0.056681 (rank : 292)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	209	Target Neighborhood Hits	1376	Shared Neighborhood Hits	53
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

P85B_HUMAN
NC score	0.056112 (rank : 293)	θ value	8.99809 (rank : 205)
Query Neighborhood Hits	209	Target Neighborhood Hits	543	Shared Neighborhood Hits	35
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SH3G2_MOUSE
NC score	0.056033 (rank : 294)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	209	Target Neighborhood Hits	319	Shared Neighborhood Hits	22
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

PTPRS_HUMAN
NC score	0.055704 (rank : 295)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	209	Target Neighborhood Hits	472	Shared Neighborhood Hits	13
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

CRKL_HUMAN
NC score	0.055643 (rank : 296)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	209	Target Neighborhood Hits	313	Shared Neighborhood Hits	23
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

AHI1_HUMAN
NC score	0.055506 (rank : 297)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	209	Target Neighborhood Hits	537	Shared Neighborhood Hits	30
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

CRK_MOUSE
NC score	0.055370 (rank : 298)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	209	Target Neighborhood Hits	314	Shared Neighborhood Hits	25
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SHAN2_MOUSE
NC score	0.055051 (rank : 299)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	209	Target Neighborhood Hits	446	Shared Neighborhood Hits	39
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

ABI3_MOUSE
NC score	0.054688 (rank : 300)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	209	Target Neighborhood Hits	227	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

PTPRD_HUMAN
NC score	0.054475 (rank : 301)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	209	Target Neighborhood Hits	485	Shared Neighborhood Hits	13
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

CRKL_MOUSE
NC score	0.054266 (rank : 302)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	209	Target Neighborhood Hits	307	Shared Neighborhood Hits	23
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

PLCG1_MOUSE
NC score	0.053933 (rank : 303)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	209	Target Neighborhood Hits	314	Shared Neighborhood Hits	29
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

NEBL_HUMAN
NC score	0.053729 (rank : 304)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	209	Target Neighborhood Hits	457	Shared Neighborhood Hits	33
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

RIMB1_HUMAN
NC score	0.053729 (rank : 305)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	209	Target Neighborhood Hits	1479	Shared Neighborhood Hits	61
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

CRK_HUMAN
NC score	0.053441 (rank : 306)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	209	Target Neighborhood Hits	308	Shared Neighborhood Hits	24
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

PTPRF_HUMAN
NC score	0.053157 (rank : 307)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	209	Target Neighborhood Hits	489	Shared Neighborhood Hits	12
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

OSTF1_HUMAN
NC score	0.053131 (rank : 308)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	209	Target Neighborhood Hits	466	Shared Neighborhood Hits	24
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

PLCG1_HUMAN
NC score	0.053052 (rank : 309)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	209	Target Neighborhood Hits	293	Shared Neighborhood Hits	29
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

OSTF1_MOUSE
NC score	0.052840 (rank : 310)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	209	Target Neighborhood Hits	467	Shared Neighborhood Hits	24
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

DBNL_HUMAN
NC score	0.052823 (rank : 311)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	209	Target Neighborhood Hits	244	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

TCGAP_HUMAN
NC score	0.052823 (rank : 312)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	209	Target Neighborhood Hits	872	Shared Neighborhood Hits	49
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

P85B_MOUSE
NC score	0.052791 (rank : 313)	θ value	8.99809 (rank : 206)
Query Neighborhood Hits	209	Target Neighborhood Hits	519	Shared Neighborhood Hits	35
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PTPRD_MOUSE
NC score	0.052299 (rank : 314)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	209	Target Neighborhood Hits	491	Shared Neighborhood Hits	13
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

RHG04_HUMAN
NC score	0.052240 (rank : 315)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	209	Target Neighborhood Hits	307	Shared Neighborhood Hits	31
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

CEND1_HUMAN
NC score	0.052219 (rank : 316)	θ value	2.36792 (rank : 175)
Query Neighborhood Hits	209	Target Neighborhood Hits	284	Shared Neighborhood Hits	54
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

IQEC3_HUMAN
NC score	0.051687 (rank : 317)	θ value	0.813845 (rank : 158)
Query Neighborhood Hits	209	Target Neighborhood Hits	125	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

DBNL_MOUSE
NC score	0.051520 (rank : 318)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	209	Target Neighborhood Hits	306	Shared Neighborhood Hits	25
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DAPP1_MOUSE
NC score	0.051046 (rank : 319)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	209	Target Neighborhood Hits	225	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

NOXO1_MOUSE
NC score	0.050940 (rank : 320)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	209	Target Neighborhood Hits	114	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

AHI1_MOUSE
NC score	0.050935 (rank : 321)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	209	Target Neighborhood Hits	496	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

EP15R_MOUSE
NC score	0.050491 (rank : 322)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	209	Target Neighborhood Hits	1135	Shared Neighborhood Hits	42
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

EP15R_HUMAN
NC score	0.050251 (rank : 323)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	209	Target Neighborhood Hits	1083	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

DAPP1_HUMAN
NC score	0.050225 (rank : 324)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	209	Target Neighborhood Hits	227	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PHLB2_MOUSE
NC score	0.049854 (rank : 325)	θ value	1.81305 (rank : 174)
Query Neighborhood Hits	209	Target Neighborhood Hits	1016	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PHLB2_HUMAN
NC score	0.047825 (rank : 326)	θ value	5.27518 (rank : 195)
Query Neighborhood Hits	209	Target Neighborhood Hits	964	Shared Neighborhood Hits	60
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

K1914_MOUSE
NC score	0.046434 (rank : 327)	θ value	1.81305 (rank : 173)
Query Neighborhood Hits	209	Target Neighborhood Hits	216	Shared Neighborhood Hits	23
SwissProt Accessions	Q5DTU0, Q8BID1, Q8K2G0	Gene names	Kiaa1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

SPTA2_HUMAN
NC score	0.045741 (rank : 328)	θ value	4.03905 (rank : 192)
Query Neighborhood Hits	209	Target Neighborhood Hits	888	Shared Neighborhood Hits	47
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

CEND1_MOUSE
NC score	0.045184 (rank : 329)	θ value	3.0926 (rank : 180)
Query Neighborhood Hits	209	Target Neighborhood Hits	260	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

TARA_MOUSE
NC score	0.044882 (rank : 330)	θ value	8.99809 (rank : 209)
Query Neighborhood Hits	209	Target Neighborhood Hits	1133	Shared Neighborhood Hits	67
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

IQEC3_MOUSE
NC score	0.041826 (rank : 331)	θ value	4.03905 (rank : 189)
Query Neighborhood Hits	209	Target Neighborhood Hits	274	Shared Neighborhood Hits	24
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

CEND3_HUMAN
NC score	0.038470 (rank : 332)	θ value	1.06291 (rank : 161)
Query Neighborhood Hits	209	Target Neighborhood Hits	275	Shared Neighborhood Hits	41
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

BSN_HUMAN
NC score	0.038186 (rank : 333)	θ value	0.0431538 (rank : 134)
Query Neighborhood Hits	209	Target Neighborhood Hits	1537	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CEND3_MOUSE
NC score	0.036976 (rank : 334)	θ value	1.38821 (rank : 166)
Query Neighborhood Hits	209	Target Neighborhood Hits	228	Shared Neighborhood Hits	35
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CCD21_MOUSE
NC score	0.036593 (rank : 335)	θ value	4.03905 (rank : 188)
Query Neighborhood Hits	209	Target Neighborhood Hits	1135	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

RGS3_MOUSE
NC score	0.031344 (rank : 336)	θ value	0.0961366 (rank : 139)
Query Neighborhood Hits	209	Target Neighborhood Hits	1621	Shared Neighborhood Hits	42
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

BSN_MOUSE
NC score	0.029310 (rank : 337)	θ value	3.0926 (rank : 179)
Query Neighborhood Hits	209	Target Neighborhood Hits	2057	Shared Neighborhood Hits	57
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

TPR_HUMAN
NC score	0.028588 (rank : 338)	θ value	3.0926 (rank : 187)
Query Neighborhood Hits	209	Target Neighborhood Hits	1921	Shared Neighborhood Hits	63
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

TARA_HUMAN
NC score	0.027403 (rank : 339)	θ value	5.27518 (rank : 197)
Query Neighborhood Hits	209	Target Neighborhood Hits	1626	Shared Neighborhood Hits	64
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

ZIMP7_MOUSE
NC score	0.026433 (rank : 340)	θ value	0.0563607 (rank : 138)
Query Neighborhood Hits	209	Target Neighborhood Hits	566	Shared Neighborhood Hits	16
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

RASA3_HUMAN
NC score	0.026049 (rank : 341)	θ value	4.03905 (rank : 191)
Query Neighborhood Hits	209	Target Neighborhood Hits	166	Shared Neighborhood Hits	31
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

SRRM2_HUMAN
NC score	0.025554 (rank : 342)	θ value	3.0926 (rank : 184)
Query Neighborhood Hits	209	Target Neighborhood Hits	1296	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

RASA3_MOUSE
NC score	0.024080 (rank : 343)	θ value	3.0926 (rank : 183)
Query Neighborhood Hits	209	Target Neighborhood Hits	144	Shared Neighborhood Hits	26
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

DYNA_HUMAN
NC score	0.023358 (rank : 344)	θ value	1.06291 (rank : 162)
Query Neighborhood Hits	209	Target Neighborhood Hits	1194	Shared Neighborhood Hits	44
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

TCF20_MOUSE
NC score	0.022683 (rank : 345)	θ value	1.38821 (rank : 167)
Query Neighborhood Hits	209	Target Neighborhood Hits	396	Shared Neighborhood Hits	25
SwissProt Accessions	Q9EPQ8, Q60792	Gene names	Tcf20, Spbp
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP).

STAP2_MOUSE
NC score	0.022052 (rank : 346)	θ value	3.0926 (rank : 185)
Query Neighborhood Hits	209	Target Neighborhood Hits	41	Shared Neighborhood Hits	8
SwissProt Accessions	Q8R0L1, Q8BWS2	Gene names	Stap2
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 2 (STAP-2).

CO002_HUMAN
NC score	0.020711 (rank : 347)	θ value	0.21417 (rank : 144)
Query Neighborhood Hits	209	Target Neighborhood Hits	387	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NZP6	Gene names	C15orf2
Domain Architecture	No domain graphic available
Description	Protein C15orf2.

PLEC1_HUMAN
NC score	0.018418 (rank : 348)	θ value	8.99809 (rank : 207)
Query Neighborhood Hits	209	Target Neighborhood Hits	1326	Shared Neighborhood Hits	44
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

SSFA2_HUMAN
NC score	0.016598 (rank : 349)	θ value	8.99809 (rank : 208)
Query Neighborhood Hits	209	Target Neighborhood Hits	40	Shared Neighborhood Hits	8
SwissProt Accessions	P28290, Q96E36	Gene names	SSFA2, CS1
Domain Architecture	No domain graphic available
Description	Sperm-specific antigen 2 (Cleavage signal-1 protein) (CS-1).

STK31_HUMAN
NC score	0.016510 (rank : 350)	θ value	5.27518 (rank : 196)
Query Neighborhood Hits	209	Target Neighborhood Hits	570	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

K1802_MOUSE
NC score	0.014545 (rank : 351)	θ value	0.0431538 (rank : 136)
Query Neighborhood Hits	209	Target Neighborhood Hits	1596	Shared Neighborhood Hits	37
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

TCF20_HUMAN
NC score	0.013084 (rank : 352)	θ value	3.0926 (rank : 186)
Query Neighborhood Hits	209	Target Neighborhood Hits	323	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UGU0, O14528, Q13078, Q4V353, Q9H4M0	Gene names	TCF20, KIAA0292, SPBP
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP) (AR1).

NUF2_HUMAN
NC score	0.012599 (rank : 353)	θ value	3.0926 (rank : 182)
Query Neighborhood Hits	209	Target Neighborhood Hits	661	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BZD4, Q8WU69, Q96HJ4, Q96Q78	Gene names	CDCA1, NUF2, NUF2R
Domain Architecture	No domain graphic available
Description	Kinetochore protein Nuf2 (hNuf2) (hNuf2R) (hsNuf2) (Cell division cycle-associated protein 1).

SON_HUMAN
NC score	0.011792 (rank : 354)	θ value	2.36792 (rank : 176)
Query Neighborhood Hits	209	Target Neighborhood Hits	1568	Shared Neighborhood Hits	45
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

ANK2_HUMAN
NC score	0.011682 (rank : 355)	θ value	3.0926 (rank : 177)
Query Neighborhood Hits	209	Target Neighborhood Hits	1615	Shared Neighborhood Hits	49
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

NPTX2_HUMAN
NC score	0.011381 (rank : 356)	θ value	0.813845 (rank : 159)
Query Neighborhood Hits	209	Target Neighborhood Hits	86	Shared Neighborhood Hits	3
SwissProt Accessions	P47972, Q86XV7, Q96G70	Gene names	NPTX2
Domain Architecture
Description	Neuronal pentraxin-2 precursor (NP2) (Neuronal pentraxin II) (NP-II).

ACOT2_HUMAN
NC score	0.011321 (rank : 357)	θ value	1.81305 (rank : 171)
Query Neighborhood Hits	209	Target Neighborhood Hits	15	Shared Neighborhood Hits	5
SwissProt Accessions	P49753, Q9NUX4	Gene names	ACOT2, PTE2, PTE2A
Domain Architecture
Description	Acyl-coenzyme A thioesterase 2 (EC 3.1.2.2) (Acyl-CoA thioesterase 2) (Peroxisomal acyl-coenzyme A thioester hydrolase 2a) (Peroxisomal long-chain acyl-coA thioesterase 2) (ZAP128) (CTE-Ia).

STK10_HUMAN
NC score	0.011275 (rank : 358)	θ value	1.06291 (rank : 164)
Query Neighborhood Hits	209	Target Neighborhood Hits	1921	Shared Neighborhood Hits	44
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

MYCB2_HUMAN
NC score	0.010072 (rank : 359)	θ value	6.88961 (rank : 202)
Query Neighborhood Hits	209	Target Neighborhood Hits	390	Shared Neighborhood Hits	17
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

NPTX2_MOUSE
NC score	0.009398 (rank : 360)	θ value	3.0926 (rank : 181)
Query Neighborhood Hits	209	Target Neighborhood Hits	79	Shared Neighborhood Hits	3
SwissProt Accessions	O70340	Gene names	Nptx2
Domain Architecture
Description	Neuronal pentraxin-2 precursor (NP2) (Neuronal pentraxin II) (NP-II).

YETS2_MOUSE
NC score	0.009197 (rank : 361)	θ value	1.38821 (rank : 169)
Query Neighborhood Hits	209	Target Neighborhood Hits	278	Shared Neighborhood Hits	8
SwissProt Accessions	Q3TUF7, Q6PGF8, Q80TI2, Q8CG86	Gene names	Yeats2, Kiaa1197
Domain Architecture	No domain graphic available
Description	YEATS domain-containing protein 2.

ACOT1_HUMAN
NC score	0.007743 (rank : 362)	θ value	6.88961 (rank : 199)
Query Neighborhood Hits	209	Target Neighborhood Hits	16	Shared Neighborhood Hits	5
SwissProt Accessions	Q86TX2, Q3I5F9	Gene names	ACOT1, CTE1
Domain Architecture	No domain graphic available
Description	Acyl-coenzyme A thioesterase 1 (EC 3.1.2.2) (Acyl-CoA thioesterase 1) (Inducible cytosolic acyl-coenzyme A thioester hydrolase) (Long chain acyl-CoA thioester hydrolase) (Long chain acyl-CoA hydrolase) (CTE-I) (CTE-Ib).

NF2L2_MOUSE
NC score	0.006497 (rank : 363)	θ value	5.27518 (rank : 194)
Query Neighborhood Hits	209	Target Neighborhood Hits	183	Shared Neighborhood Hits	6
SwissProt Accessions	Q60795	Gene names	Nfe2l2, Nrf-2, Nrf2
Domain Architecture
Description	Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nuclear factor, erythroid derived 2, like 2).

TTC28_HUMAN
NC score	0.006473 (rank : 364)	θ value	5.27518 (rank : 198)
Query Neighborhood Hits	209	Target Neighborhood Hits	271	Shared Neighborhood Hits	18
SwissProt Accessions	Q96AY4, O95928, O95929, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5	Gene names	TTC28, KIAA1043
Domain Architecture
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

JHD3B_HUMAN
NC score	0.006207 (rank : 365)	θ value	4.03905 (rank : 190)
Query Neighborhood Hits	209	Target Neighborhood Hits	128	Shared Neighborhood Hits	10
SwissProt Accessions	O94953, O75274, Q6P3R5, Q9P1V1, Q9UF40	Gene names	JMJD2B, JHDM3B, KIAA0876
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3B (EC 1.14.11.-) (Jumonji domain-containing protein 2B).

TXLNG_MOUSE
NC score	0.006112 (rank : 366)	θ value	6.88961 (rank : 203)
Query Neighborhood Hits	209	Target Neighborhood Hits	552	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BHN1, Q8BP11	Gene names	Txlng
Domain Architecture	No domain graphic available
Description	Gamma-taxilin.

CT075_MOUSE
NC score	0.005524 (rank : 367)	θ value	0.365318 (rank : 151)
Query Neighborhood Hits	209	Target Neighborhood Hits	358	Shared Neighborhood Hits	6
SwissProt Accessions	P59383	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf75 homolog precursor.

TXLNG_HUMAN
NC score	0.005307 (rank : 368)	θ value	4.03905 (rank : 193)
Query Neighborhood Hits	209	Target Neighborhood Hits	568	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NUQ3, Q9P0X1	Gene names	TXLNG, CXorf15, LSR5
Domain Architecture	No domain graphic available
Description	Gamma-taxilin (Lipopolysaccharide-specific response protein 5).

PLXA1_MOUSE
NC score	0.003677 (rank : 369)	θ value	1.06291 (rank : 163)
Query Neighborhood Hits	209	Target Neighborhood Hits	107	Shared Neighborhood Hits	4
SwissProt Accessions	P70206, Q5DTR0	Gene names	Plxna1, KIAA4053
Domain Architecture	No domain graphic available
Description	Plexin-A1 precursor (Plexin-1) (Plex 1).

TRIM7_HUMAN
NC score	0.003599 (rank : 370)	θ value	1.38821 (rank : 168)
Query Neighborhood Hits	209	Target Neighborhood Hits	336	Shared Neighborhood Hits	6
SwissProt Accessions	Q9C029, Q969F5, Q96F67, Q96J89, Q96J90	Gene names	TRIM7, GNIP, RNF90
Domain Architecture
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein) (RING finger protein 90).

ANK3_HUMAN
NC score	0.003327 (rank : 371)	θ value	0.125558 (rank : 140)
Query Neighborhood Hits	209	Target Neighborhood Hits	853	Shared Neighborhood Hits	16
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

ARNT_MOUSE
NC score	0.003282 (rank : 372)	θ value	3.0926 (rank : 178)
Query Neighborhood Hits	209	Target Neighborhood Hits	213	Shared Neighborhood Hits	9
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

K1802_HUMAN
NC score	0.002943 (rank : 373)	θ value	6.88961 (rank : 200)
Query Neighborhood Hits	209	Target Neighborhood Hits	1378	Shared Neighborhood Hits	24
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

COIA1_MOUSE
NC score	0.002884 (rank : 374)	θ value	1.81305 (rank : 172)
Query Neighborhood Hits	209	Target Neighborhood Hits	481	Shared Neighborhood Hits	13
SwissProt Accessions	P39061, Q60672, Q61437, Q62001, Q62002, Q9JK63	Gene names	Col18a1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

ACTN4_MOUSE
NC score	0.002321 (rank : 375)	θ value	8.99809 (rank : 204)
Query Neighborhood Hits	209	Target Neighborhood Hits	276	Shared Neighborhood Hits	10
SwissProt Accessions	P57780	Gene names	Actn4
Domain Architecture
Description	Alpha-actinin-4 (Non-muscle alpha-actinin 4) (F-actin cross-linking protein).

MOK_MOUSE
NC score	-0.002090 (rank : 376)	θ value	0.125558 (rank : 141)
Query Neighborhood Hits	209	Target Neighborhood Hits	796	Shared Neighborhood Hits	5
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

LRIG1_HUMAN
NC score	-0.002607 (rank : 377)	θ value	6.88961 (rank : 201)
Query Neighborhood Hits	209	Target Neighborhood Hits	654	Shared Neighborhood Hits	6
SwissProt Accessions	Q96JA1, Q6IQ51, Q96CF9, Q9BYB8, Q9UFI4	Gene names	LRIG1, LIG1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

ZN516_MOUSE
NC score	-0.004701 (rank : 378)	θ value	1.38821 (rank : 170)
Query Neighborhood Hits	209	Target Neighborhood Hits	1197	Shared Neighborhood Hits	17
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.